A benign tumor of the PANCREATIC BETA CELLS. Insulinoma secretes excess INSULIN resulting in HYPOGLYCEMIA.
A benign tumor of the pancreatic ISLET CELLS. Usually it involves the INSULIN-producing PANCREATIC BETA CELLS, as in INSULINOMA, resulting in HYPERINSULINISM.
Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).
Irregular microscopic structures consisting of cords of endocrine cells that are scattered throughout the PANCREAS among the exocrine acini. Each islet is surrounded by connective tissue fibers and penetrated by a network of capillaries. There are four major cell types. The most abundant beta cells (50-80%) secrete INSULIN. Alpha cells (5-20%) secrete GLUCAGON. PP cells (10-35%) secrete PANCREATIC POLYPEPTIDE. Delta cells (~5%) secrete SOMATOSTATIN.
A 51-amino acid pancreatic hormone that plays a major role in the regulation of glucose metabolism, directly by suppressing endogenous glucose production (GLYCOGENOLYSIS; GLUCONEOGENESIS) and indirectly by suppressing GLUCAGON secretion and LIPOLYSIS. Native insulin is a globular protein comprised of a zinc-coordinated hexamer. Each insulin monomer containing two chains, A (21 residues) and B (30 residues), linked by two disulfide bonds. Insulin is used as a drug to control insulin-dependent diabetes mellitus (DIABETES MELLITUS, TYPE 1).
An inherited autosomal recessive syndrome characterized by the disorganized formation of new islets in the PANCREAS and CONGENITAL HYPERINSULINISM. It is due to focal hyperplasia of pancreatic ISLET CELLS budding off from the ductal structures and forming new islets of Langerhans. Mutations in the islet cells involve the potassium channel gene KCNJ11 or the ATP-binding cassette transporter gene ABCC8, both on CHROMOSOME 11.
A syndrome of abnormally low BLOOD GLUCOSE level. Clinical hypoglycemia has diverse etiologies. Severe hypoglycemia eventually lead to glucose deprivation of the CENTRAL NERVOUS SYSTEM resulting in HUNGER; SWEATING; PARESTHESIA; impaired mental function; SEIZURES; COMA; and even DEATH.
A type of pancreatic cell representing about 50-80% of the islet cells. Beta cells secrete INSULIN.
A pancreatic polypeptide of about 110 amino acids, depending on the species, that is the precursor of insulin. Proinsulin, produced by the PANCREATIC BETA CELLS, is comprised sequentially of the N-terminal B-chain, the proteolytically removable connecting C-peptide, and the C-terminal A-chain. It also contains three disulfide bonds, two between A-chain and B-chain. After cleavage at two locations, insulin and C-peptide are the secreted products. Intact proinsulin with low bioactivity also is secreted in small amounts.
A primary source of energy for living organisms. It is naturally occurring and is found in fruits and other parts of plants in its free state. It is used therapeutically in fluid and nutrient replacement.
Surgical removal of the pancreas. (Dorland, 28th ed)
A glucose transport facilitator that is expressed primarily in PANCREATIC BETA CELLS; LIVER; and KIDNEYS. It may function as a GLUCOSE sensor to regulate INSULIN release and glucose HOMEOSTASIS.
Cells grown in vitro from neoplastic tissue. If they can be established as a TUMOR CELL LINE, they can be propagated in cell culture indefinitely.
A calcium-independent phospholipase A2 group that may play a role in membrane phospholipid remodeling and homeostasis by controling the levels of PHOSPHATIDYLCHOLINE in mammalian cell membranes.
An almost always malignant GLUCAGON-secreting tumor derived from the PANCREATIC ALPHA CELLS. It is characterized by a distinctive migratory ERYTHEMA; WEIGHT LOSS; STOMATITIS; GLOSSITIS; DIABETES MELLITUS; hypoaminoacidemia; and normochromic normocytic ANEMIA.
The calcium salt of gluconic acid. The compound has a variety of uses, including its use as a calcium replenisher in hypocalcemic states.
A potent, long-acting synthetic SOMATOSTATIN octapeptide analog that inhibits secretion of GROWTH HORMONE and is used to treat hormone-secreting tumors; DIABETES MELLITUS; HYPOTENSION, ORTHOSTATIC; HYPERINSULINISM; hypergastrinemia; and small bowel fistula.
A sulphonylurea hypoglycemic agent with actions and uses similar to those of CHLORPROPAMIDE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p290)
Cell surface receptors that bind glucagon with high affinity and trigger intracellular changes which influence the behavior of cells. Activation of glucagon receptors causes a variety of effects; the best understood is the initiation of a complex enzymatic cascade in the liver which ultimately increases the availability of glucose to body organs.
A subclass of receptor-like protein tryosine phosphatases that contain an extracellular RDGS-adhesion recognition motif and a single cytosolic protein tyrosine phosphate domain.
A serine endopeptidase that has specificity for cleavage at ARGININE. It cleaves a variety of prohormones including PRO-OPIOMELANOCORTIN, proluteinizing-hormone-releasing hormone, proenkephalins, prodynorphin, and PROINSULIN.
Secretagogins are EF HAND MOTIF-containing calcium-binding proteins that are involved in early neuronal migration and neurogenesis. They are also present in many adult organs and in brain and endocrine neoplasms.
A form of multiple endocrine neoplasia that is characterized by the combined occurrence of tumors in the PARATHYROID GLANDS, the PITUITARY GLAND, and the PANCREATIC ISLETS. The resulting clinical signs include HYPERPARATHYROIDISM; HYPERCALCEMIA; HYPERPROLACTINEMIA; CUSHING DISEASE; GASTRINOMA; and ZOLLINGER-ELLISON SYNDROME. This disease is due to loss-of-function of the MEN1 gene, a tumor suppressor gene (GENES, TUMOR SUPPRESSOR) on CHROMOSOME 11 (Locus: 11q13).
Tumors whose cells possess secretory granules and originate from the neuroectoderm, i.e., the cells of the ectoblast or epiblast that program the neuroendocrine system. Common properties across most neuroendocrine tumors include ectopic hormone production (often via APUD CELLS), the presence of tumor-associated antigens, and isozyme composition.
That part of the genome that corresponds to the complete complement of EXONS of an organism or cell.
A ubiquitously expressed zinc finger-containing protein that acts both as a repressor and activator of transcription. It interacts with key regulatory proteins such as TATA-BINDING PROTEIN; TFIIB; and ADENOVIRUS E1A PROTEINS.
A group of carcinomas which share a characteristic morphology, often being composed of clusters and trabecular sheets of round "blue cells", granular chromatin, and an attenuated rim of poorly demarcated cytoplasm. Neuroendocrine tumors include carcinoids, small ("oat") cell carcinomas, medullary carcinoma of the thyroid, Merkel cell tumor, cutaneous neuroendocrine carcinoma, pancreatic islet cell tumors, and pheochromocytoma. Neurosecretory granules are found within the tumor cells. (Segen, Dictionary of Modern Medicine, 1992)
A tumor that secretes VASOACTIVE INTESTINAL PEPTIDE, a neuropeptide that causes VASODILATION; relaxation of smooth muscles; watery DIARRHEA; HYPOKALEMIA; and HYPOCHLORHYDRIA. Vipomas, derived from the pancreatic ISLET CELLS, generally are malignant and can secrete other hormones. In most cases, Vipomas are located in the PANCREAS but can be found in extrapancreatic sites.
A 52-amino acid peptide with multi-functions. It was originally isolated from PHEOCHROMOCYTOMA and ADRENAL MEDULLA but is widely distributed throughout the body including lung and kidney tissues. Besides controlling fluid-electrolyte homeostasis, adrenomedullin is a potent vasodilator and can inhibit pituitary ACTH secretion.
Members of the class of compounds composed of AMINO ACIDS joined together by peptide bonds between adjacent amino acids into linear, branched or cyclical structures. OLIGOPEPTIDES are composed of approximately 2-12 amino acids. Polypeptides are composed of approximately 13 or more amino acids. PROTEINS are linear polypeptides that are normally synthesized on RIBOSOMES.
G-protein-coupled cell surface receptors for ADRENOMEDULLIN. They are formed by the heterodimerization of CALCITONIN RECEPTOR-LIKE PROTEIN and either RECEPTOR ACTIVITY-MODIFYING PROTEIN 2 or RECEPTOR ACTIVITY-MODIFYING PROTEIN 3.
Activities performed to identify concepts and aspects of published information and research reports.
Use of sophisticated analysis tools to sort through, organize, examine, and combine large sets of information.
A publication issued at stated, more or less regular, intervals.
A procedure in which a laparoscope (LAPAROSCOPES) is inserted through a small incision near the navel to examine the abdominal and pelvic organs in the PERITONEAL CAVITY. If appropriate, biopsy or surgery can be performed during laparoscopy.
Excision of the gallbladder through an abdominal incision using a laparoscope.
A group of telomere associated proteins that interact with TRF1 PROTEIN, contain ANKYRIN REPEATS and have poly(ADP-ribose) polymerase activity.
An enzyme that catalyzes the formation of nicotinamide mononucleotide (NMN) from nicotinamide and 5-phosphoribosyl-1-pyrophosphate, the rate-limiting step in the biosynthesis of the NAD coenzyme. It is also known as a growth factor for early B-LYMPHOCYTES, or an ADIPOKINE with insulin-mimetic effects (visfatin).
A coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH). (Dorland, 27th ed)
An enzyme that catalyzes reversibly the transfer of the adenylyl moiety of ATP to the phosphoryl group of NMN to form NAD+ and pyrophosphate. The enzyme is found predominantly in the nuclei and catalyzes the final reaction in the major pathway for the biosynthesis of NAD in mammals. EC 2.7.7.1.
Colorless, odorless crystals that are used extensively in research laboratories for the preparation of polyacrylamide gels for electrophoresis and in organic synthesis, and polymerization. Some of its polymers are used in sewage and wastewater treatment, permanent press fabrics, and as soil conditioning agents.
Surgical therapy of ischemic coronary artery disease achieved by grafting a section of saphenous vein, internal mammary artery, or other substitute between the aorta and the obstructed coronary artery distal to the obstructive lesion.
Blood tests used to evaluate the functioning of the thyroid gland.
The main glucocorticoid secreted by the ADRENAL CORTEX. Its synthetic counterpart is used, either as an injection or topically, in the treatment of inflammation, allergy, collagen diseases, asthma, adrenocortical deficiency, shock, and some neoplastic conditions.
The state of weariness following a period of exertion, mental or physical, characterized by a decreased capacity for work and reduced efficiency to respond to stimuli.
Insulin-like polypeptides made by the liver and some fibroblasts and released into the blood when stimulated by SOMATOTROPIN. They cause sulfate incorporation into collagen, RNA, and DNA synthesis, which are prerequisites to cell division and growth of the organism.
Pathological processes of CORONARY ARTERIES that may derive from a congenital abnormality, atherosclerotic, or non-atherosclerotic cause.
Diseases in any segment of the GASTROINTESTINAL TRACT from ESOPHAGUS to RECTUM.
A disorder with chronic or recurrent colonic symptoms without a clearcut etiology. This condition is characterized by chronic or recurrent ABDOMINAL PAIN, bloating, MUCUS in FECES, and an erratic disturbance of DEFECATION.
Chronic or recurrent colonic disorders without an identifiable structural or biochemical explanation. The widely recognized IRRITABLE BOWEL SYNDROME falls into this category.
Sensation of discomfort, distress, or agony in the abdominal region.

RINm5f cells express inactivating BK channels whereas HIT cells express noninactivating BK channels. (1/873)

Large-conductance Ca2+- and voltage-activated BK-type K+ channels are expressed abundantly in normal rat pancreatic islet cells and in the clonal rat insulinoma tumor (RINm5f) and hamster insulinoma tumor (HIT) beta cell lines. Previous work has suggested that the Ca2+ sensitivity of BK channels in RIN cells is substantially less than that in HIT cells, perhaps contributing to differences between the cell lines in responsiveness to glucose in mediating insulin secretion. In both RIN cells and normal pancreatic beta cells, BK channels are thought to play a limited role in responses of beta cells to secretagogues and in the electrical activity of beta cells. Here we examine in detail the properties of BK channels in RIN and HIT cells using inside-out patches and whole cell recordings. BK channels in RIN cells exhibit rapid inactivation that results in an anomalous steady-state Ca2+ dependence of activation. In contrast, BK channels in HIT cells exhibit the more usual noninactivating behavior. When BK inactivation is taken into account, the Ca2+ and voltage dependence of activation of BK channels in RIN and HIT cells is essentially indistinguishable. The properties of BK channel inactivation in RIN cells are similar to those of inactivating BK channels (termed BKi channels) previously identified in rat chromaffin cells. Inactivation involves multiple, trypsin-sensitive cytosolic domains and exhibits a dependence on Ca2+ and voltage that appears to arise from coupling to channel activation. In addition, the rates of inactivation onset and recovery are similar to that of BKi channels in chromaffin cells. The charybdotoxin (CTX) sensitivity of BKi currents is somewhat less than that of the noninactivating BK variant. Action potential voltage-clamp waveforms indicate that BK current is activated only weakly by Ca2+ influx in RIN cells but more strongly activated in HIT cells even when Ca2+ current magnitude is comparable. Concentrations of CTX sufficient to block BKi current in RIN cells have no effect on action potential activity initiated by glucose or DC injection. Despite its abundant expression in RIN cells, BKi current appears to play little role in action potential activity initiated by glucose or DC injection in RIN cells, but BK current may play an important role in action potential repolarization in HIT cells.  (+info)

Islet amyloid polypeptide/amylin messenger RNA and protein expression in human insulinomas in relation to amyloid formation. (2/873)

OBJECTIVE: Islet amyloid polypeptide (IAPP), also named amylin, is the predominant protein component of amyloid deposits in human islet beta cell tumours of the pancreas (insulinomas). IAPP is co-produced with insulin by islet beta cells. We investigated IAPP expression in relation to insulin expression and to amyloid formation in eleven insulinomas. DESIGN AND METHODS: RNA and protein extracts were prepared from the same pieces of tumour tissue, and from specimens of two normal human pancreata. IAPP and insulin mRNA and peptide content were quantified using Northern blot analysis and radioimmunoassay (RIA) respectively. Molecular forms of IAPP immunoreactivity were analysed by reversed-phase high-performance liquid chromatography (HPLC). The presence of islet hormones and of amyloid was assessed by (immuno)histochemical staining of paraffin sections. Plasma levels of IAPP and insulin prior to tumour resection were determined by RIA. RESULTS: IAPP and insulin mRNA and peptide content varied widely between the tumour specimens, and there was considerable intratumour heterogeneity of peptide content. HPLC analysis indicated correct proteolytic processing of the IAPP precursor protein. Amyloid deposits were detected only in the three tumours with the highest IAPP content. In contrast to insulin, plasma levels of IAPP were not elevated in the insulinoma patients. CONCLUSIONS: The spectrum of hormone production by insulinomas cannot be inferred from only a few tissue sections due to intratumour heterogeneity. Expression of the IAPP and insulin genes is not coupled in insulinomas, which produce properly processed mature IAPP. In addition to IAPP overproduction, additional factors such as intracellular accumulation of IAPP are involved in amyloidogenesis in insulinomas.  (+info)

Dual actions of the metabolic inhibitor, sodium azide on K(ATP) channel currents in the rat CRI-G1 insulinoma cell line. (3/873)

1. The effects of various inhibitors of the mitochondrial electron transport chain on the activity of ATP-sensitive K+ channels were examined in the Cambridge rat insulinoma G1 (CRI-G1) cell line using a combination of whole cell and single channel recording techniques. 2. Whole cell current clamp recordings, with 5 mM ATP in the pipette, demonstrate that the mitochondrial uncoupler sodium azide (3 mM) rapidly hyperpolarizes CRI-G1 cells with a concomitant increase in K+ conductance. This is due to activation of K(ATP) channels as the sulphonylurea tolbutamide (100 microM) completely reversed the actions of azide. Other inhibitors of the mitochondrial electron transport chain, rotenone (10 microM) or oligomycin (2 microM) did not hyperpolarize CRI-G1 cells or increase K+ conductance. 3. In cell-attached recordings, bath application of 3 mM sodium azide (in the absence of glucose) resulted in a rapid increase in K(ATP) channel activity, an action readily reversible by tolbutamide (100 microM). Application of sodium azide (3 mM), in the presence of Mg-ATP, to the intracellular surface of excised inside-out patches also increased K(ATP) channel activity, in a reversible manner. 4. In contrast, rotenone (10 microM) or oligomycin (2 microM) did not increase K(ATP) channel activity in either cell-attached, in the absence of glucose, or inside-out membrane patch recordings. 5. Addition of sodium azide (3 mM) to the intracellular surface of inside-out membrane patches in the presence of Mg-free ATP or the non-hydrolysable analogue 5'-adenylylimidodiphosphate (AMP-PNP) inhibited, rather than increased, K(ATP) channel activity. 6. In conclusion, sodium azide, but not rotenone or oligomycin, directly activates K(ATP) channels in CRI-G1 insulin secreting cells. This action of azide is similar to that reported previously for diazoxide.  (+info)

RIN ZF, a novel zinc finger gene, encodes proteins that bind to the CACC element of the gastrin promoter. (4/873)

Expression of gastrin, a gut hormone and growth factor, has tissue-specific transcriptional regulation and can be induced in some tumors. Previous studies have shown that a CACC cis-regulatory element is important for transcriptional activation in pancreatic insulinoma cells. To identify CACC-binding proteins, a lambda phage cDNA library derived from a rat insulinoma cell line, RIN 38A, was screened by a Southwestern method. A novel member of the Cys2-His2 zinc finger gene family was cloned and designated RIN ZF, having a cDNA sequence of 3.8 kilobases. One full-length and a shorter splice variant were sequenced and had predicted protein masses of 91.6 and 88.7 kDa. Expression of both splice forms were ubiquitous in fetal and adult rat tissues. Recombinant RIN ZF protein exhibited sequence-specific binding to the gastrin CACC element in a gel mobility shift assay. In transient transfections, both splice variants appeared to have only weak activating effects on gastrin-luciferase reporter gene transcription. Furthermore, RIN ZF coexpression with Sp1 appeared to block the strongly activating effects of Sp1 mediated through the CACC element. These findings suggest that a novel set of zinc finger proteins may help regulate gastrin gene expression by interfering with Sp1 transactivation.  (+info)

Essential role of caspase-3 in apoptosis of mouse beta-cells transfected with human Fas. (5/873)

Several recent studies have indicated that the Fas-Fas ligand system may be critical for pancreatic beta-cell destruction in type 1 diabetes. Although the fundamental roles of caspases in the mammalian apoptotic machinery have been elucidated, it is not known which caspase or caspases play a major role in Fas-mediated apoptosis of beta-cells. In this study, we transfected human Fas cDNA into a mouse beta-cell line (betaTC1) and established a beta-cell clone expressing human Fas. This clone, designated hFas/betaTC1, underwent apoptosis when exposed to anti-Fas, showing hallmarks of apoptosis (chromatin condensation, nucleolar disintegration, internucleosomal DNA fragmentation, and annexin V staining), indicating that the mouse beta-cell line has the intact machinery of Fas-mediated apoptosis. The cross-linking of Fas by anti-Fas resulted in the elevation of caspase-3-like, but not caspase-1-like, protease activity 2-12 h after the addition of the anti-Fas. A caspase-3 inhibitor, Z-Asp-Glu-Val-Asp-fluoromethyl ketone, attenuated the Fas-mediated beta-cell apoptosis, while a caspase-1 inhibitor, acetyl-Tyr-Val-Ala-Asp-chloromethylketone, failed to suppress the apoptosis. Thus the Fas-induced death signal apparently bypassed caspase-1 in the cells. Furthermore, an antisense caspase-3 construct blocked caspase-3 activation and substantially suppressed Fas-triggered apoptosis of hFas/betaTC1 cells. These observations suggest the essential role of caspase-3 in Fas-mediated apoptosis of the beta-cell line.  (+info)

Site-specific phosphorylation of synapsin I by Ca2+/calmodulin-dependent protein kinase II in pancreatic betaTC3 cells: synapsin I is not associated with insulin secretory granules. (6/873)

Increasing evidence supports a physiological role of Ca2+/calmodulin-dependent protein kinase II (CaM kinase II) in the secretion of insulin from the pancreatic beta-cell, but the precise sites of action are not known. A role of this enzyme in neuroexocytosis is implicated by its phosphorylation of a vesicle-associated protein, synapsin I. Because of emerging similarities to the neuron with respect to exocytotic mechanisms, the expression and phosphorylation of synapsin I in the beta-cell have been studied. Synapsin I expression in clonal mouse beta-cells (betaTC3) and primary rat islet beta-cells was initially confirmed by immunoblot analysis. By immunoprecipitation, in situ phosphorylation of synapsin I was induced in permeabilized betaTC3 cells within a Ca2+ concentration range shown to activate endogenous CaM kinase II under identical conditions. Proteolytic digests of these immunoprecipitates revealed that calcium primarily induced the increased phosphorylation of sites identified as CaM kinase II-specific and distinct from protein kinase A-specific sites. Immunofluorescence and immunogold electron microscopy verified synapsin I expression in betaTC3 cells and pancreatic slices but demonstrated little if any colocalization of synapsin I with insulin-containing dense core granules. Thus, although this study establishes that synapsin I is a substrate for CaM kinase II in the pancreatic beta-cell, this event appears not to be important for the mobilization of insulin granules.  (+info)

Molecular cloning of a pancreatic islet-specific glucose-6-phosphatase catalytic subunit-related protein. (7/873)

A pancreatic islet-specific glucose-6-phosphatase-related protein (IGRP) was cloned using a subtractive cDNA expression cloning procedure from mouse insulinoma tissue. Two alternatively spliced variants that differed by the presence or absence of a 118-bp exon (exon IV) were detected in normal balb/c mice, diabetic ob/ob mice, and insulinoma tissue. The longer, 1901-bp full-length cDNA encoded a 355-amino acid protein (molecular weight 40,684) structurally related (50% overall identity) to the liver glucose-6-phosphatase and exhibited similar predicted transmembrane topology, conservation of catalytically important residues, and the presence of an endoplasmic reticulum retention signal. The shorter transcript encoded two possible open reading frames (ORFs), neither of which possessed His174, a residue thought to be the phosphoryl acceptor (Pan CJ, Lei KJ, Annabi B, Hemrika W, Chou JY: Transmembrane topology of glucose-6-phosphatase. J Biol Chem 273:6144-6148, 1998). Northern blot and reverse transcription-polymerase chain reaction analysis showed that the mRNA was highly expressed in pancreatic islets and expressed more in beta-cell lines than in an alpha-cell line. It was notably absent in tissues and cell lines of non-islet neuroendocrine origin, and no other major tissue source of the mRNA was found. During development, it was expressed in parallel with insulin mRNA. The mRNA was efficiently translated and glycosylated in an in vitro translation/membrane translocation system and readily transcribed into COS 1, HIT, and CHO cells using cytomegalovirus or Rous sarcoma virus promoters. Whereas the liver glucose-6-phosphatase showed activity in these transfection systems, the IGRP failed to show glucose phosphotransferase or phosphatase activity with p-nitrophenol phosphate, inorganic pyrophosphate, or a range of sugar phosphates hydrolyzed by the liver enzyme. While the metabolic function of the enzyme is not resolved, its remarkable tissue-specific expression warrants further investigation, as does its transcriptional regulation in conditions where glucose responsiveness of the pancreatic islet is altered.  (+info)

Beta-cell gene expression and functional characterisation of the human insulinoma cell line CM. (8/873)

Animal insulinoma cell lines are widely used to study physiological and pathophysiological mechanisms involved in glucose metabolism and to establish in vitro models for studies on beta-cells. In contrast, human insulinoma cell lines are rarely used because of difficulties in obtaining and culturing them for long periods. The aim of our study was to investigate, under different experimental conditions, the capacity of the human insulinoma cell line CM to retain beta-cell function, particularly the expression of constitutive beta-cell genes (insulin, the glucose transporters GLUT1 and GLUT2, glucokinase), intracellular and secreted insulin, beta-cell granules, and cAMP content. Results showed that CM cells from an early-passage express specific beta-cell genes in response to glucose stimulation, in particular the insulin and GLUT genes. Such capacity is lost at later passages when cells are cultured at standard glucose concentrations. However, if cultured at lower glucose concentration (0.8 mM) for a longer time, CM cells re-acquire the capacity to respond to glucose stimulation, as shown by the increased expression of beta-cell genes (insulin, GLUT2, glucokinase). Nonetheless, insulin secretion could not be restored under such experimental conditions despite the presence of intracellular insulin, although cAMP response to a potent activator of adenylate cyclase, forskolin, was present indicating a viable system. In conclusion, these data show that the human insulinoma cell line CM, at both early-passage and late-passage, posseses a functional glucose-signalling pathway and insulin mRNA expression similar to normal beta-cells, representing, therefore, a good model for studies concerning the signalling and expression of beta-cells. Furthermore, we have previously shown that it is also a good model for immunological studies. In this respect it is important to note that the CM cell line is one of the very few existing human beta-cell lines in long-term culture.  (+info)

TY - JOUR. T1 - Gene expression profiling in human insulinoma tissue. T2 - Genes involved in the insulin secretion pathway and cloning of novel full-length cDNAs. AU - Wang, X. C.. AU - Xu, S. Y.. AU - Wu, X. Y.. AU - Song, H. D.. AU - Mao, Y. F.. AU - Fan, H. Y.. AU - Yu, F.. AU - Mou, B.. AU - Gu, Y. Y.. AU - Xu, L. Q.. AU - Zhou, X. O.. AU - Chen, Z.. AU - Chen, J. L.. AU - Hu, R. M.. PY - 2004/6. Y1 - 2004/6. N2 - Insulinoma is a clinically common cause of organic hypoglycemia. The prominent characteristic of insulinoma is endogenous hyperinsulinism. Until now, the molecular biology of human insulinoma has been little understood. In this study, gene expression profiling of human insulinoma was established by expressed sequence tag (EST) sequencing and cDNA array. A total of 2063 clones were obtained, of these, 1589 clones were derived from EST sequencing, 975 clones were derived from cDNA array and 501 clones were shared by the two methods. G protein α-stimulating activity polypeptide ...
TY - JOUR. T1 - Cyclic AMP regulates a calcium-activated non-selective cation channel in a rat insulinoma cell line. AU - Reale, V.. AU - Hales, C. N.. AU - Ashford, M. L.J.. PY - 1992/3/30. Y1 - 1992/3/30. UR - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1180011/pdf/jphysiol00436-0003.pdf. UR - http://www.scopus.com/inward/record.url?scp=0026585003&partnerID=8YFLogxK. M3 - Article. AN - SCOPUS:0026585003. VL - 446. JO - Journal of Physiology. JF - Journal of Physiology. SN - 0022-3751. ER - ...
TY - JOUR. T1 - Extracellular loop cysteine mutant of Cx37 fails To suppress proliferation of rat insulinoma cells. AU - Good, Miranda E.. AU - Ek-Vitorín, José F.. AU - Burt, Janis M.. PY - 2012/7. Y1 - 2012/7. N2 - Although a functional pore domain is required for connexin 37 (Cx37)-mediated suppression of rat insulinoma (Rin) cell proliferation, it is unknown whether functional hemichannels would be sufficient or if Cx37 gap junction channels are required for growth suppression. To test this possibility, we targeted extracellular loop cysteines for mutation, expecting that the mutated protein would retain hemichannel, but not gap junction channel, functionality. Cysteines at positions 61 and 65 in the first extracellular loop of Cx37 were mutated to alanine and the mutant protein (Cx37-C61,65A) expressed in Rin cells. Although the resulting iRin37-C61,65A cells expressed the mutant protein comparably to Cx37 wild-type (Cx37-WT)-expressing Rin cells (iRin37), Cx37-C61,65A expression did not ...
Yu Wenbin, MD, PhD, Hu Sanyuan, MD, PhD, Zhang Guangyong, Zhan Hanxiang, Liu Shaozhuang, Wang Xiaoyang. Department of general surgery,Qilu hospital of Shandong University. OBJECTIVE To investigate the feasibility and safety for laparoscopic therapy to insulinoma.. METHODS Retrospectively analyzed twenty-one insulinoma patients (8 men and 13 women; mean age, 47 years) who underwent laparoscopic therapy from June, 2004 to October, 2011. Tumor position located at pancreatic body and tail in 11 patients; at neck in 2 patients; at head and uncinate in one patient respectively.. RESULTS Insulinoma location were confirmed preoperatively in insulinoma patients and accepted laparoscopic therapy (13 patients underwent laparoscopic enucleation of the insulinoma, 4 patients underwent laparoscopic distal pancreatectomy, one patient accepted hand assisted laparoscopic uncinate insulinoma resection, 3 patients converted to laparotomy). At follow-up (range, 10-88 months), local recurrence and recurrent ...
This study investigates the occurrence and regulation of serine/threonine protein phosphatases (PPases) in insulin-secreting RINm5F insulinoma cells. PPases types 1 and 2A were identified in crude RINm5F cell homogenates by both enzymatic assay and Western blot analysis. We then characterized and compared the inhibitory actions of several compounds isolated from cyanobacteria, marine dinoflagellates and marine sponges, (viz. okadaic acid, microcystin-LR, calyculin-A and nodularin) cation-independent PPase activities in RINm5F cell homogenates. It was found that okadaic acid was the least potent inhibitor (IC50 ≈ 10−9M, IC100 ≈ 10−6M), while the other compounds exhibited IC50 values of ≈ 5·10−10 M and IC100 ≈ 5·10−9 M. The findings indicate that the inhibitory substances employed in this study may be used pharmacologically to investigate the role of serine/threonine PPases in RINm5F cell insulin secretion, a process that is likely to be regulated to a major extent by protein ...
TY - JOUR. T1 - Insulinoma.. AU - Burns, Andrew R.. AU - Dackiw, Alan P B. PY - 2003/8. Y1 - 2003/8. N2 - Insulinomas are the most common islet cell tumors and are located almost exclusively in the pancreas. Most of these tumors are sporadic, but they may also be associated with the multiple endocrine neoplasia type I syndrome. More than 90% of insulinomas are benign. Preoperative radiographic localization may prove difficult. Intraoperative palpation and ultrasound remain the gold standard for detection and appropriately planned resection. Although many options are available to treat the patient with malignant and metastatic disease, the mainstay of treatment remains surgery. Laparoscopic ultrasound and enucleation/resection may be increasingly used in the management of patients with insulinoma.. AB - Insulinomas are the most common islet cell tumors and are located almost exclusively in the pancreas. Most of these tumors are sporadic, but they may also be associated with the multiple endocrine ...
TY - JOUR. T1 - Clonal insulinoma cell line that stably maintains correct glucose responsiveness. AU - Knaack, D.. AU - Fiore, D. M.. AU - Surana, M.. AU - Leiser, M.. AU - Laurance, M.. AU - Fusco-DeMane, D.. AU - Hegre, O. D.. AU - Fleischer, N.. AU - Efrat, S.. PY - 1994/12/1. Y1 - 1994/12/1. N2 - A number of pancreatic β-tumor cell (βTC) lines have been derived from insulinomas arising in transgenic mice expressing the SV40 T antigen gene under control of the insulin promoter. Some of these lines secrete insulin in response to physiological glucose concentrations. However, this phenotype is unstable. After propagation in culture, these nonclonal lines become responsive to subphysiological glucose levels and/or manifest reduced insulin release. Here we report the use of soft-agar cloning to isolate single-cell clones from a βTC line, which give rise to sublines that maintain correct glucose responsiveness and high insulin production and secretion for ,55 passages (over a year) in culture. ...
OBJECTIVE CD4 T-cells secreting interleukin (IL)-17 are implicated in several human autoimmune diseases, but their role in type 1 diabetes has not been defined. To address the relevance of such cells, we examined IL-17 secretion in response to β-cell autoantigens, IL-17A gene expression in islets, and the potential functional consequences of IL-17 release for β-cells. RESEARCH DESIGN AND METHODS Peripheral blood CD4 T-cell responses to β-cell autoantigens (proinsulin, insulinoma-associated protein, and GAD65 peptides) were measured by IL-17 enzyme-linked immunospot assay in patients with new-onset type 1 diabetes (n = 50). mRNA expression of IL-17A and IFNG pathway genes was studied by qRT-PCR using islets obtained from subjects who died 5 days and 10 years after diagnosis of disease, respectively, and from matched control subjects. IL-17 effects on the function of human islets, rat β-cells, and the rat insulinoma cell line INS-1E were examined. RESULTS A total of 27 patients (54%) showed ...
TY - JOUR. T1 - Usefulness of the index calculated as the product of levels of fasting plasma glucose and hemoglobin A1c for insulinoma screening. AU - Torimoto, Keiichi. AU - Okada, Yosuke. AU - Tanaka, Yoshiya. AU - Matsuoka, Atsuko. AU - Hirota, Yushi. AU - Ogawa, Wataru. AU - Saisho, Yoshifumi. AU - Kurihara, Isao. AU - Itoh, Hiroshi. AU - Inada, Shinya. AU - Koga, Masafumi. N1 - Publisher Copyright: © The Japan Endocrine Society.. PY - 2020. Y1 - 2020. N2 - Hypoglycemia is the major symptom of insulinoma. Chronic and recurrent hypoglycemia leads to the disappearance of autonomic symptoms and persistence of non-specific symptoms alone, possibly contributing to the delayed diagnosis of insulinoma and accounting for several undiagnosed cases. We previously reported the usefulness of hemoglobin A1c (HbA1c) and glycated albumin as markers for early insulinoma screening; however, their diagnostic prediction performance and diagnostic performance were not satisfactory. We hypothesized that the ...
Large-conductance Ca2+- and voltage-dependent potassium (BK) channels exhibit functional diversity not explained by known splice variants of the single Slo α-subunit. Here we describe an accessory subunit (β3) with homology to other β-subunits of BK channels that confers inactivation when it is coexpressed with Slo. Message encoding the β3 subunit is found in rat insulinoma tumor (RINm5f) cells and adrenal chromaffin cells, both of which express inactivating BK channels. Channels resulting from coexpression of Slo α and β3 subunits exhibit properties characteristic of native inactivating BK channels. Inactivation involves multiple cytosolic, trypsin-sensitive domains. The time constant of inactivation reaches a limiting value ∼25-30 msec at Ca2+ of 10 μm and positive activation potentials. Unlike Shaker N-terminal inactivation, but like native inactivating BK channels, a cytosolic channel blocker does not compete with the native inactivation process. Finally, the β3 subunit confers a ...
A 23-year old female patient suffered from frequent hypoglycemic attacks. A Volume Perfusion CT was performed to localize the insulinoma. Read more here.
Glibenclamide, a blocker of ATP-sensitive potassium channels, has been found to induce apoptosis in some cell types, including pancreatic beta-cells. Since
Islet cell autoantigen of 69kDa (ICA69) is a small GTPase-binding protein of unknown function. ICA69 is enriched in the Golgi complex and its N-terminal half contains a BAR domain, a module that can bind/bend membranes and interacts with phospholipids. Here we show that in insulinoma INS-1 cells ICA69 binds to the small GTPase Rab2, which regulates the transport of COPI vesicles between the endoplasmic reticulum and the Golgi complex. Rab2 binds to ICA69 in a GTP-dependent fashion and recruits it to membranes. Over-expression of either Rab2 or ICA69 in INS-1 cells results in a phenotype characterized by: (i) impaired anterograde transport of the secretory granule protein precursors pro-ICA512 and chromogranin A; (ii) reduction of stimulated insulin secretion. Taken together, these data identify ICA69 as a novel Rab2 effector and point to its role in regulating the early transport of insulin secretory granule proteins.
Vol 5 | Issue 3 | Sep-Dec 2019 | page: 24-27 | Reshma S Pharande, Vinaya Kulkarni, Rohit Sancheti, Sunita Khedkar Authors: Reshma S Pharande [1], Vinaya Kulkarni [1], Rohit Sancheti [1], Sunita Khedkar [1] Address of Correspondence Dr. Vinaya Kulkarni, Department of Anaesthesia, BJGMC, Pune, Maharashtra, India E-mail: [email protected] 1 Department of Anaesthesia, BJGMC, Pune. Introduction: Insulinoma is a rare neuroendocrine tumor of the pancreas that produces symptoms due to hypersecretion of insulin from β-cells. They are often misdiagnosed or have delayed diagnosis due to their bizarre clinical presentation. Diagnosis is made based on history (Whipples triad), biochemical tests and imaging modalities. Surgical resection is the curative treatment. General anaesthesia is an ideal technique as it reduces the cerebral metabolism and oxygen consumption. We present a case of an 45 year old female patient diagnosed with insulinoma who had history of recurrent hypoglycemic attacks. Surgical enucleation
We report on a case of malignant insulinoma occurring in a patient with genuine insulin-dependent diabetes mellitus (IDDM). A review of cases concerning patients with diabetes mellitus and insulinomas is presented, and reveals only patients with non-insulin-dependent diabetes mellitus (NIDDM). Our case appears to be the first in showing the combination of IDDM and a functioning malignant insulinoma.. ...
Hypoglycaemia as a result of insulin secreting tumours can be treated effectively by surgery. However pre-operative localization is desirable as the majority of these tumours are small and in 20% of the cases may be multiple. We describe a 1 cm insulinoma being localized preoperatively by selective arterial stimulation with calcium and venous sampling for insulin. This technique is sensitive and relatively non-invasive. We believe that it is potentially very valuable in pre-operative localization of occult insulinomas ...
What is Insulinoma ? In general an Insulinoma is a neuroendocrine tumor which is rare. The name itself tells you a bit about where it is and what it does. This
Our previous work demonstrated that knockout of p110γ results in a blunted glucose-stimulated insulin response, particularly during the first phase of secretion (18). We have now examined the underlying mechanism for regulation of insulin secretion by p110γ. This PI3K isoform positively regulates the size of the membrane-associated pool of insulin granules, likely through the modulation of cortical F-actin density. Therefore, we now identify a previously undescribed role for PI3Kγ in the regulation of cortical actin and targeting of insulin granules to the plasma membrane in pancreatic β-cells.. The tyrosine kinase-activated isoforms of PI3K (type 1A) account for as much as 80% of islet PI3K activity (3). The type 1B isoform, p110γ, is expressed in insulinoma cells, rodent islets, and human islets (18) (Fig. 1), where it contributes a minor fraction of PI3K activity (17). The nonselective nature of commonly used PI3K inhibitors may account for earlier findings ascribing both negative (1-3) ...
TY - JOUR. T1 - Peak stimulated insulin secretion is associated with specific changes in gene expression profiles in sporadic insulinomas. AU - Kayton, Mark L.. AU - Costouros, Nick G.. AU - Lorang, Dominique. AU - Alexander, H. Richard. AU - Hewitt, Stephen M.. AU - Cochran, Craig. AU - Shalev, Anath. AU - Harlan, David. AU - Skarulis, Monica C.. AU - Gorden, Philip. AU - Libutti, Steven K.. AU - Parangi, Sareh. AU - Imamura, Masayuki. AU - Hodin, Richard A.. AU - Zeiger, Martha A.. PY - 2003/12. Y1 - 2003/12. N2 - Background. The molecular pathways that are responsible for pathologic insulin secretion by insulinomas have not been characterized. We studied gene expression profiles from insulinomas and determined associations between these changes and preoperative peak serum insulin levels. Methods. Ten patients with insulinomas underwent calcium-stimulated arteriography and surgical resection. Tumor RNA was isolated; corresponding complementary DNA was hybridized to 10K human complementary DNA ...
Engineered insulinoma cell lines may represent an alternative to isolated islets for transplantation therapy of type 1 diabetes. Success of this approach may require development of cell lines that can withstand cytokine-mediated damage. To this end, we have cultured INS-1 insulinoma cells in increasing concentrations of interleukin-1beta (IL-1beta) + gamma-interferon (IFN-gamma), with approximate weekly iterations over an 8-week period. Based on the C,N diphenyl-N-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium+ ++ bromide (MTT) viability assay, the selected cells, termed INS-1res, were 100% viable after 5 days of treatment with 10 ng/ml of IL-1beta. These cells were also 78 +/- 1.2% viable after 5 days of exposure to the combination of 10 ng/ml IL-1beta and 100 U/ml IFN-gamma, whereas parental INS-1 cells treated in the same manner were only 0.3 +/- 0.03% viable. INS-1res cells were also resistant to treatment with supernatants from activated rat peripheral blood mononuclear cells, whereas ...
BACKGROUND. Adenocarcinoma. Pancreatic tumors are uncommon in both cats and dogs. Pancreatic tumors are divided into exocrine and endocrine neoplasia. Exocrine pancreatic tumors are usually malignant adenocarcinomas. Diffuse involvement of the pancreas is common and they are often associated with obstruction of the common bile duct (causing jaundice). There is a very high risk of metastasis. Insulinoma. Insulinomas arising from pancreatic islet cells are the most common endocrine pancreatic tumor in dogs. Insulinomas cause hypoglycemia (or low blood glucose). Hypoglycemia is responsible for the clinical signs seen in dogs with insulinomas, such as weakness, ataxia, collapse, and convulsions. Metastasis to the regional lymph nodes and liver is common.. DIAGNOSIS. An insulinoma is highly suspected when blood tests reveal simultaneous hypoglycemia and hyperinsulinemia (or high blood insulin). Ultrasonography is recommended for both diagnosis and clinical staging of cats and dogs with any type of ...
Contraindications. ZEGALOGUE is contraindicated in patients with pheochromocytoma because of the risk of substantial increase in blood pressure and in patients with insulinoma because of the risk of hypoglycemia.. Warnings and Precautions. ZEGALOGUE is contraindicated in patients with pheochromocytoma because glucagon products may stimulate the release of catecholamines from the tumor. If the patient develops a substantial increase in blood pressure and a previously undiagnosed pheochromocytoma is suspected, 5 to 10 mg of phentolamine mesylate, administered intravenously, has been shown to be effective in lowering blood pressure.. In patients with insulinoma, administration of glucagon products may produce an initial increase in blood glucose; however, ZEGALOGUE administration may directly or indirectly (through an initial rise in blood glucose) stimulate exaggerated insulin release from an insulinoma and cause hypoglycemia. ZEGALOGUE is contraindicated in patients with insulinoma. If a patient ...
Find details on Pancreas: neoplasia: insulinoma in dogs including diagnosis and symptoms, pathogenesis, prevention, treatment, prognosis and more. All information is peer reviewed.
Insulinoma treatment with partial pancreas resection (costs for program #139803) ✔ University Hospital Münster ✔ Department of General and Visceral Surgery ✔ BookingHealth.com
Diagnosis of insulinoma (costs for program #174029) ✔ DKD HELIOS Clinic Wiesbaden ✔ Department of Pediatrics ✔ BookingHealth.com
Insulinoma - Etiology, pathophysiology, symptoms, signs, diagnosis & prognosis from the MSD Manuals - Medical Professional Version.
Insulinoma - Etiology, pathophysiology, symptoms, signs, diagnosis & prognosis from the Merck Manuals - Medical Professional Version.
We have cloned an inwardly rectifying K+ channel from the hamster insulinoma cDNA library and shown that it is inhibited by cytoplasmic ATP. The channel is 90.97% identical to the IRK3 channels cloned from other species, and its mRNA is found primarily in the brain. When expressed in Xenopus oocytes, the channel displays strong inward rectification typical of inward rectifiers. The channel is inhibited reversibly by physiological concentrations of ATP via a mechanism that does not appear to involve ATP hydrolysis, as shown by studies of channels in excised inside-out membrane patches. This effect is antagonized by ADP, again in the physiological range, implying that this channel is sensitive to the index of metabolic state, i.e., the intracellular [ATP]/[ADP] ratio. This channel is different from previously known ATP-sensitive K+ channels, although it may also be stimulated by MgATP, as are other ATP-sensitive K+ channels. The potential physiological significance of these ATP-dependent ...
We have shown that the bone marrow contributes to myofibroblast and fibroblast populations in a mouse model of pancreatic insulinoma. Additionally, we have shown in our mouse model that bone marrow can contribute to insulin-producing cell types within the insulinomas and also that there are cells that display phenotypic characteristics of both the donor and the recipient (SV40 and Y).. In the development of tumors, the interaction between the tumor and the host is often characterized by a desmoplastic reaction. The role of the desmoplastic response to tumors is not completely understood although a cancer-induced change in the stroma may contribute to cancer invasion (5) .. In normal circumstances, the interaction between normal epithelium and normal stroma helps to maintain tissue integrity. However, in cancer, the interaction between cancer cells and the surrounding stroma via signals such as transforming growth factor β and platelet-derived growth factor results in the formation of an ...
Introduction: The 72-hour fasting test is the gold standard for the diagnosis of insulinoma. However, the test can become a burden for both patients and medical staff and, shortening the duration of fast has been attempted. There are several reports on the high sensitivity of fasting test but only a few reports on its specificity. An insulinoma can be localized using invasive tests such as endoscopic ultrasonography and selective arterial secretagogue injection test. Therefore, insulinoma detection with high specificity may be needed to avoid unnecessary examinations ...
Presented by Bernadette U Laxa, MD SS21 Videos Solid Organ and Foregut: V050 disclosure-21 sec case hx-24 sec CT-1:17 procedural video-1:35 post-op course-5:54 Q&A session-6:19 Keyword(s): diplopia, distal pancreatectomy, enucleation, fibrin glue, hemostatic agents, hypoglycemia, intra-op bleeding, modified lithotomy, neuroendocrine tumor, pancreatic insulinoma, split leg position, Tisseel, vascular loop. ...
Neurotrophins and Neurotrophin Receptors mRNAs Expression in Pancreatic Islets and Insulinoma Cell Lines, Paolo Bonini, Daniela Pierucci, Simona Cicconi, O
Tumors on your pancreas, called insulinomas, make extra insulin, more than your body can use. This causes blood sugar levels to drop too low. This can cause symptoms of low blood sugar or hypoglycemia.
Diagnosis is based on anamnesis, examination results (including neurological examination) and registered a decline of plasma glucose in those cases where it is proved that the secretion of insulin with enhanced or not inhibitedand excluded other causes of hypoglycemia (use of hypoglycemic agents, diseases of the hypothalamic-pituitary system, adrenal lesions, hepatic failure, some other tumors).. To do this, carry out a test with fasting, investigate the secretion of proinsulin, C-peptide, cortisol.For the differential diagnosis and clarify the features may require instrumental examination (ultrasound, CT angiography).. Treatment is aimed at the normalization of plasma glucose levels.Possible subsequent surgery to remove the tumor.Patients with metastatic or ineffective surgical treatment is prescribed chemotherapy.. ...
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DI-fusion, le Dépôt institutionnel numérique de lULB, est loutil de référencementde la production scientifique de lULB.Linterface de recherche DI-fusion permet de consulter les publications des chercheurs de lULB et les thèses qui y ont été défendues.
My colleagues next door (endocrinology lab) routinely transfect insulinoma cells like RINm5F, INS-1 and pancreatic ductal line PANC-1 using GenCarrier-1. They are pretty satisfied with what they got so far.. ...
Peer Review History: A Malignant Metastatic Insulinoma as the First Clinical Presentation of Multiple Endocrine Neoplasia Type 1: A Case ...
The two most common types of pancreatic neuroendocrine tumors (PanNETs) are insulinomas and nonfunctioning PanNETs (NF-PanNETs). Insulinomas are small, rarely metastatic tumors that secrete high amounts of insulin, and nonfunctioning PanNETs are larger tumors that are frequently metastatic but that do not secrete hormones. Insulinomas are modeled by the highly studied RIP1-Tag2 (RT2) transgenic mice when bred into a C57Bl/6 (B6) genetic background (also known as RT2 B6 mice). But there has been a need for an animal model of nonfunctioning PanNETs, which in the clinic are a more common and severe disease. Here we show that when bred into a hybrid AB6F1 genetic background, RT2 mice make nonfunctioning PanNETs. Compared to insulinomas produced by RT2 B6 mice, the tumors produced by RT2 AB6F1 mice were larger and more metastatic, and the animals did not suffer from hypoglycemia or hyperinsulinemia. Genetic crosses revealed that a locus in mouse chromosome 2qG1 was linked to liver metastasis and to ...
Chinese researchers from Rui-Jin Hospital, Shanghai Jiao-Tong University School of Medicine, BGI and other institutes identified the recurrent T372R mutation in the transcription factor YY1 (Yin Yang 1) are related with insulinoma oncogenesis, implicating a potential marker for the diagnosis and treatment of functional pancreatic neuroendocrine tumors (PNETs). The latest study was published online in Nature Communications.. Pancreatic neuroendocrine tumors are classified into functional and nonfunctional tumors by hormone secretion and clinical symptoms. Functional PNETs are mainly represented by insulinoma, which secrete insulin independent of glucose and cause hypoglycemia. The major genetic alterations in insulinomas are still unknown.. In this study, researchers identified T372R mutation in YY1 by whole exome sequencing of 10 sporadic insulinomas samples. It is noteworthy that the T372R mutation was the first reported in public available databases such as 1,000 Genomes and dbSNP database. ...
TY - JOUR. T1 - Activation of a novel non-selective cation channel by alloxan and H2O2 in the rat insulin-secreting cell line CRI-G1. AU - Herson, P. S.. AU - Ashford, M. L.. PY - 1997/5/15. Y1 - 1997/5/15. N2 - 1. Alloxan and its auto-oxidation product hydrogen peroxide (H2O2) irreversibly depolarize insulinoma cells by opening a non-selective cation channel. The channel opened is characterized by a linear current-voltage relation with a conductance of approximately 70 pS and very slow kinetics (of the order of seconds). 2. Cells are protected against the alloxan-induced channel opening and consequent cell depolarization by the presence of H2O2 and hydroxyl radical scavengers. 3. The free radical-activated non-selective cation channel is not operative in isolated patches but can be activated by the application of beta-NAD+ to the cytoplasmic aspect of the membrane.. AB - 1. Alloxan and its auto-oxidation product hydrogen peroxide (H2O2) irreversibly depolarize insulinoma cells by opening a ...
What Is an Insulinoma?. An insulinoma (also known as beta-cell carcinoma and islet cell carcinoma) is a tumor of the pancreas that causes an increase in the secretion of insulin, which leads to severely low blood sugar (hypoglycemia). Insulinomas are common in middle-aged to older ferrets, most commonly those aged 3 to 4 years and older. They can develop in both male and female ferrets.. What Are the Clinical Signs of Insulinoma?. Signs of the disease may appear suddenly as an episode of collapse lasting from minutes to hours. During such an episode, the ferret usually appears depressed, recumbent (unable to stand), and unresponsive. In severe cases, seizures may occur. However, in many ferrets, clinical signs appear gradually as progressive weakness and lethargy (tiredness) over weeks to months. Excessive salivation, pawing at the mouth, and weakness of the hindlimbs are also common. These signs may be intermittent, with periods of normal activity in between periods of lethargy.. Prolonged, ...
Cytokines produced by immune cells infiltrating pancreatic islets are important mediators of β-cell destruction in insulin-dependent diabetes mellitus. Cytokines stimulate an inducible form of nitric oxide synthase (iNOS) expression and nitric oxide (NO) production, leading to insulin insufficiency. In the present study, the effects of Artemisia capillaris extract (ACE) on cytokine-induced β-cell damage were examined. Treatment of RINm5F (RIN) rat insulinoma cells with interleukin-1β (IL-1β) and interferon-γ (IFN-γ) induced cell damage. ACE completely protected IL-1β and IFN-γ-mediated cytotoxicity in a concentration-dependent manner. Incubation with ACE resulted in a significant reduction in IL-1β and IFN-γ-induced NO production, a finding that correlated well with reduced levels of the iNOS mRNA and protein. The molecular mechanism by which ACE inhibited iNOS gene expression appeared to involve the inhibition of NF-κB activation. The IL-1β and IFN-γ-stimulated RIN cells showed ...
Insulinomas are the most common cause of hypoglycemia resulting from endogenous hyperinsulinism. Traditionally, inappropriately elevated levels of insulin in the face of hypoglycemia are the key to diagnosis. However, contradictory levels of insulin and C-peptide do not necessarily exclude the diagnosis. A 50-year-old female was brought to our emergency department because of conscious disturbance on the previous night. She had no history of diabetes mellitus, and was not using any medications or alcohol. Laboratory data showed low sugar, a significantly low insulin level, and elevated C-peptide. After admission, she had multiple episodes of spontaneous hypoglycemia after overnight fasts without discomfort. It was considered that a neuroendocrine tumor was the source of her hypoglycemia. CT scan of the abdomen revealed a 1.1cm hypervascular nodule in the pancreatic tail. Elective laparoscopic distal pancreatectomy was incorporated into her treatment course. A 1.2×1.0cm homogenous ...
Insulinomas are the most common cause of hypoglycemia resulting from endogenous hyperinsulinism. Traditionally, inappropriately elevated levels of insulin in the face of hypoglycemia are the key to diagnosis. However, contradictory levels of insulin and C-peptide do not necessarily exclude the diagnosis. A 50-year-old female was brought to our emergency department because of conscious disturbance on the previous night. She had no history of diabetes mellitus, and was not using any medications or alcohol. Laboratory data showed low sugar, a significantly low insulin level, and elevated C-peptide. After admission, she had multiple episodes of spontaneous hypoglycemia after overnight fasts without discomfort. It was considered that a neuroendocrine tumor was the source of her hypoglycemia. CT scan of the abdomen revealed a 1.1cm hypervascular nodule in the pancreatic tail. Elective laparoscopic distal pancreatectomy was incorporated into her treatment course. A 1.2×1.0cm homogenous ...
The patient under discussion had presented with right renal mass lesion and hyperinsulinemic hypoglycemia. We initially considered the possibility of incidentally detected right renal cell carcinoma in patient with insulinoma. In our Institute, we have both PET and SPECT imaging agents for octreoscan available for the localisation of insulinoma. Somatostain receptor scintigraphy (SRS) is an established functional imaging method for patients with NETs. The sensitivity of SRS for insulinoma is 50 - 60% [12]. We did both 68Ga-Dotanoc and 99mTc-HYNICTOC scans for the localisation of insulinoma which unexpectedly revealed increased uptake in the right renal mass lesion itself confirming it to be a NET. To the best of our knowledge, this is the first case of ectopic insulin secretion confirmed in vivo by 68Ga-Dotanoc and 99mTc-HYNICTOC scan. Further, the neuroendocrine and insulin secreting nature of the tumour was confirmed ex vivo by histopathological examination, immunohistochemistry and ...
New insulin-secreting cell lines (INS-1 and INS-2) were established from cells isolated from an x-ray-induced rat transplantable insulinoma. The continuous growth of these cells was found to be dependent on the reducing agent 2-mercaptoethanol. Removal of this thiol compound caused a 15-fold drop in …
PJ Hale, I Jensen, RM Baddeley, M Nattrass; Insulin and Proinsulin Concentrations in Patients with Insulinoma before and after Surgical Treatment. Clin Sci (Lond) 1 January 1988; 75 (s19): 15P. doi: https://doi.org/10.1042/cs075015P. Download citation file:. ...
The mean fasting insulin level in 30 apparently normal Kenyan Africans was determined by Radio-Immuno Assay (RIA) technique based on coat A-count. The mean value was found as 16.33 microIu/ml with a standard deviation (s.d) of 10.51 microIu/ml. The mean at 95% confidence interval (CI) for the population studied was 16.33 +/- 1.92. The findings are similar to what have been reported among the caucasians. This paper also reports on a case of insulinoma in a young female patient at Kenyatta National Hospital (KNH).. ...
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Introduction Ferrets are not particularly prone to tumours, either benign or malignant, but when they do present with cancer, itread more about Insulinoma in ferrets
Introduction: Organic hyperinsulinism syndrome (OHS) is revealed in 85% cases of pancreas insulinoma. Nesidioblastosis (NB) induces OHS in 15% of the cases. Surgical cure provides all symptoms of insulinoma disappearing, while cytoreductive operation results in considerable improvement of life quality. There is no intraoperative opportunity to reveal insulinoma grade, even if an urgent biopsy is performed. Thus, it is essential to determine the cause of OHS and to apply the surgical cure method during the preoperational period, thereby improving the long-term prognosis ...
This study describes the preclinical evaluation of a DTPA linker-conjugated exendin-4 derivative for the labeling with the γ- and Auger-emitter 111In and the targeting of GLP-1 receptor-positive tumors in the Rip1Tag2 transgenic mouse model of pancreatic β-cell carcinogenesis.. The main rationale to develop a radiopeptide for the targeting of the GLP-1 receptor is based on the need to develop tools for imaging and localization of insulinomas by SPECT, PET, or use of a surgical probe for intraoperative localization.. Although sst2 receptor targeting with radiopeptides is a very successful method for the diagnosis and therapy of neuroendocrine tumors, radiolabeled peptides have not been effective enough for a curative approach (31). In addition, about 50% of insulinomas are not detectable using [111In-DTPA0]octreotide because the sst2 receptor density on the cell membrane is too low for visualization with [111In-DTPA0]octreotide (18,19). Therefore, detection of receptors expressed in higher ...
An eight-year-old Australian boy did not have a hypoglycemic attack since he received the new insulin pump a month back at The Wesley Hospital in Brisbane.
Permanent neonatal diabetes mellitus (PNDM) is a rare disorder usually presenting within 6 months of birth. Although several genes have been linked to this disorder, in almost half the cases documented in Italy, the genetic cause remains unknown. Because the Akita mouse bearing a mutation in the Ins2 gene exhibits PNDM associated with pancreatic β cell apoptosis, we sequenced the human insulin gene in PNDM subjects with unidentified mutations. We discovered 7 heterozygous mutations in 10 unrelated probands. In 8 of these patients, insulin secretion was detectable at diabetes onset, but rapidly declined over time. When these mutant proinsulins were expressed in HEK293 cells, we observed defects in insulin protein folding and secretion. In these experiments, expression of the mutant proinsulins was also associated with increased Grp78 protein expression and XBP1 mRNA splicing, 2 markers of endoplasmic reticulum stress, and with increased apoptosis. Similarly transfected INS-1E insulinoma cells ...
Sigma-Aldrich offers abstracts and full-text articles by [C Letizia, G Tamburrano, P Alo, A Paoloni, C Caliumi, E Marinoni, R di Iorio, E dErasmo].
Studies in humans and in animal models have shown that high-density lipoprotein, or HDL, reduces the risk of diabetes by decreasing ER stress and beta-cell apoptosis. Researchers also have found that the hedgehog signaling pathway and cholesterol are involved in the fate of pancreatic beta cells and insulin production.. Mustafa Yalcinkaya and colleagues at the University Hospital of Zurich, Switzerland, published a paper in the Journal of Lipid Research on the mechanism by which HDL and the hedgehog signaling molecule Smoothened, or Smo, reduce beta-cell apoptosis induced by ER stress. They treated rat insulinoma beta cells with the ER stress inducer thapsigargin in the presence or absence of native HDL or CSL-111 (an artificially reconstituted HDL). Apoptosis studies such as free nucleosome assay and Caspase-3 activity assay showed that both HDL and CSL-111 reduced apoptosis in these cells.. Similar experiments involving the knockdown of oxysterol-producing enzyme cytochrome P450 and ...
Some experimental murine tumors express target antigens restricted solely to the tumor and can therefore be efficiently cured without inducing autoimmune phenomena using, for example, DCs (15)(16)(17). In cases in which non-tumor-restricted antigens are used, autoimmune sequelae are probably not observed when the requirements for immune activity are rather low and tumor elimination is achieved before autoimmune symptoms appear (18)(19)(20). This probably depends largely on the relative size of the tumor versus the size and importance of the autoimmune target, as well as on the relative precursor and effector T cell frequencies. Furthermore, it is possible that tumor cells may provide certain factors compensating for the lack of healthy tissue that is destroyed during curative antitumor treatment (e.g., in the model study of Speiser et al. [36], where insulin-producing insulinoma cells compensate for the destruction of pancreatic β-islet cells during antitumor treatment).. Under certain ...
Islet-associated protein-2 (IA-2) and IA-2β (also known as phogrin) are unique neuroendocrine-specific protein tyrosine phosphatases (PTPs). The IA-2 family of PTPs was originally identified from insulinoma cells and discovered to be major autoantigens in type 1 diabetes. Despite its expression in the neural and canonical endocrine tissues, data on expression ...
Stimulation of pancreatic β-cells with glucose activates the protein kinases B-Raf and extracellular signal-regulated protein kinase that participate in glucose sensing. Inhibition of both kinases results in impairment of glucose-regulated gene transcription. To analyze the signaling pathway controlled by B-Raf, we expressed a conditionally active form of B-Raf in INS-1 insulinoma cells. Here, we show that stimulation of B-Raf strongly activated the transcription factor AP-1 which is accompanied by increased c-Jun and c-Fos promoter activities, an upregulation of c-Jun and c-Fos biosynthesis, and elevated transcriptional activation potentials of c-Jun and c-Fos ...
The Congress party has been wiped out from the landscape and cant be revived even if it was administered a calcium injection, AIMIM leader Asaduddin Owaisi said.
A mild hypo can be treated with carbohydrates that cross into the bloodstream quickly. Liquid foods containing a lot of sugar are quickly absorbed by the gut, and so provide a rapid increase in blood sugar. If theres a long time until your next meal, you will need to snack in between, ideally on foods rich in slow-acting carbohydrates so as to stabilise your blood sugar. Ideally, you should take something sugary with you, and a packed lunch, if you are away from home.. Examples of hypo food rich in fast-acting carbohydrates:. • Sugary drinks like fruit juices or sweetened, carbonated soft ...
A few of the symptoms discussed in this thread could be possible signs if insulinoma, such as the unexplained weight gain and fatigue. Maybe not so much the bloating though. If you hold a healthy diet and still lack of energy and always feel like your blood sugar is low you might want to look this up. Insuliomas are (in most cases) non cancerous tumors on the pancreas. It causes a high production of insulin which can lead to hunger feelings, fatigue, dizziness, nausea and hyperglycemia. Your brain does not get enough energy even though your body gets enough nutritions... If you ever have suspected diabetes but gotten negative results this might be the next step. Might not help so many of you with the gas and bloating problem primarily, but I thought is was worth mentioning for us who struggle with unexplainable weight gain despite our healthy life style ...
A few of the symptoms discussed in this thread could be possible signs if insulinoma, such as the unexplained weight gain and fatigue. Maybe not so much the bloating though. If you hold a healthy diet and still lack of energy and always feel like your blood sugar is low you might want to look this up. Insuliomas are (in most cases) non cancerous tumors on the pancreas. It causes a high production of insulin which can lead to hunger feelings, fatigue, dizziness, nausea and hyperglycemia. Your brain does not get enough energy even though your body gets enough nutritions... If you ever have suspected diabetes but gotten negative results this might be the next step. Might not help so many of you with the gas and bloating problem primarily, but I thought is was worth mentioning for us who struggle with unexplainable weight gain despite our healthy life style ...
A very rare cause is a condition where too much insulin is produced in short bursts from abnormal tissue in the pancreas (an insulinoma)...
E.J.M. Nieveen van Dijkum is the author of this article in the Journal of Visualized Experiments: Robotic Enucleation of an Intra-Pancreatic Insulinoma in the Pancreatic Head
Dr.Luiza Mitocaru is currently affiliated to Department of Endocrinology, continuing research in the specialized scientific area of andpancreatic insulinoma and Endo..
I recently posted in health about insulinoma and having to start a freeze dried diet. If yall can, please read that, and get back to me. Im debating whats the best for my babies ...
Insulinomas - tumors of the pancreas Question: DR. RICHARDS, I have a six year old shep/husky that we believe has a tumor on his pancreas, his last blood work showed his insulin level @ 1400 and his sugar level @31.His sugar level is so low he is extremely weak. I can not find anyone who has any information on the chances of removing the tumor,and the risks involved. It is very diffucult to make a decision about exploratory surgery with very little information .I understand that you cant diagnois via internet, but would appreciate greatly any input you could give me. I really need to gather facts as soon as possible. THANK YOU Answer: Joseph- Insulinomas, the tumor of the pancreas that leads to low blood sugar and high insulin production, will commonly metastasize (some people say this tumor always metastasizes) and recurrences of the tumor after removal do occur in most patients. It is a good idea to have chest X-rays taken prior to making a surgical decision, since it would be much less ...
Insulinoma[edit]. Insulinoma is a rare tumor derived from the neoplasia of beta cells. Insulinomas are usually benign, but may ... "A Clinicopathological Study of Malignant Insulinoma in a Contemporary Series". Pancreas. 46 (1): 48-56. doi:10.1097/MPA. ...
In functioning PanNETs, octreotide is usually recommended prior to biopsy or surgery but is generally avoided in insulinomas to ... Grant CS (October 2005). "Insulinoma". Best Practice & Research. Clinical Gastroenterology. 19 (5): 783-98. doi:10.1016/j.bpg. ... with peptic ulcers and diarrhea insulinoma: hypoglycemia occurs with concurrent elevations of insulin, proinsulin and C peptide ...
Insulinomas can produce large amounts of insulin, causing hypoglycemia. Pituitary adenomas can cause elevated levels of ... Grant CS (October 2005). "Insulinoma". Best Pract Res Clin Gastroenterol. 19 (5): 783-98. doi:10.1016/j.bpg.2005.05.008. PMID ...
Grant, C. (2005). "Insulinoma". Best Practice & Research Clinical Gastroenterology. 19 (5): 783-798. doi:10.1016/j.bpg.2005.05. ... Vig, S.; Lewis, M.; Foster, K. J.; Stacey-Clear, A. (2001). "Lessons to be learned: A case study approach insulinoma presenting ... Insulinomas are (pancreatic tumors) that cause an overproduction of insulin, causing hypoglycemia. Various neurological ... Morgan, J. R. (1989). "A case of Down's syndrome, insulinoma and anorexia". Journal of Mental Deficiency Research. 33 (2): 185- ...
Insulinoma[redaguoti , redaguoti vikitekstą]. Dėl insulino išskyrimo navike pacientą vargina hipoglikemijos epizodai.[3] ... Insulinoma. Best Pract Res Clin Gastroenterol. 2005 Oct;19(5):783-98. http://www.ncbi.nlm.nih.gov/pubmed/16253900 ...
2009) Pancreatic insulinoma: a surgical experience. (2009) Information theoretical methods to deconvolute genetic regulatory ...
Insulinoma-associated protein 1 is a protein that in humans is encoded by the INSM1 gene. Insulinoma-associated 1 (INSM1) gene ... "Entrez Gene: INSM1 insulinoma-associated 1". Mukhopadhyay S, Dermawan JK, Lanigan CP, Farver CF (August 2018). "Insulinoma- ... Goto Y, De Silva MG, Toscani A, Prabhakar BS, Notkins AL, Lan MS (July 1992). "A novel human insulinoma-associated cDNA, IA-1, ... and chromosomal localization of an insulinoma-associated intronless gene, IA-1". The Journal of Biological Chemistry. 269 (19 ...
Insulinoma, a type of cancer of the islet cells of the pancreas, is the most common form of cancer in ferrets. It is most ... In an insulinoma attack, a temporary remedy to stabilize the ferret is any kind of a sugary syrup, such as corn syrup or honey ... Symptoms of an insulinoma attack include episodes of lethargy, drooling, pawing or foaming at the mouth, high pitched screams, ... The exact cause of insulinoma is unknown. It is speculated that the diets of domestic ferrets are too far removed from the ...
Insulinoma, NOS (C25._) Beta cell adenoma M8151/3 Insulinoma, malignant (C25._) Beta cell tumor, malignant (M8152/0) ...
"GPR40 gene expression in human pancreas and insulinoma". Biochem. Biophys. Res. Commun. 338 (4): 1788-90. doi:10.1016/j.bbrc. ...
Diseases of the endocrine pancreas occur very infrequently; these include insulinomas, gastrinomas etc. Surgery for these ...
... is contraindicated in people with pheochromocytoma or insulinoma. https://www.accessdata.fda.gov/drugsatfda_docs/ ...
Ravnik-Oblak, M; Janez, A; Kocijanicic, A (2001). "Insulinoma induced hypoglycemia in a type 2 diabetic patient". Wiener ...
"Expression of dominant negative form of PAX4 in human insulinoma". Biochemical and Biophysical Research Communications. 282 (1 ...
Two cases of PED have been associated with insulinomas, after removal of which the symptoms of PED were resolved. Since the age ... Patients with PED associated with insulinomas appeared to have symptoms resolved after consuming sugary drinks. Currently, ... "Paroxysmal exercise-induced dystonia associated with hypoglycaemia induced by an insulinoma". J. Neurol. 249 (11): 1615-6. doi: ...
Cultured mouse insulinoma cells (MIN6 cell line): These cells can be cultured efficiently under conditions that promote the ... Mouse insulinoma cells (MIN6 cell line) and mouse pancreatic islet cells. Mouse embryonic fibroblasts (MEF) during ...
"Peripheral neuropathy and microangiopathy in rats with insulinoma: association with chronic hyperinsulinemia". Diabetes/ ...
It is not recommended in people who have a pheochromocytoma or insulinoma. Use in pregnancy has not be found to be harmful to ... Likewise, glucagon is contraindicated in patients with an insulinoma, as its hyperglycemic effect can induce the tumor to ...
This gene has been found to be activated in various tumors, such as insulinomas, esophageal cancers, and colon cancers. As is ... 1987). "Evolutionary conservation of the insulinoma gene rig and its possible function". Proc. Natl. Acad. Sci. U.S.A. 84 (19 ...
... amide receptor on insulinoma-derived cell membranes". Digestion. 55 (1): 29-33. doi:10.1159/000201119. PMID 8112494. Graziano ... "Signal transduction of the GLP-1-receptor cloned from a human insulinoma". FEBS Letters. 348 (1): 7-13. doi:10.1016/0014-5793( ...
Insulinomas are neuroendocrine tumors of the pancreas with an incidence of 0.4 %[citation needed] which usually are benign ... Jyotsna VP, Malik E, Birla S, Sharma A (2015-01-01). "Novel MEN 1 gene findings in rare sporadic insulinoma--a case control ... Menin is a 621 amino acid protein associated with insulinomas which acts as an adapter while also interacting with partner ... Pancreatic tumours involve the islet cells, giving rise to gastrinomas or insulinomas. In rare cases, adrenal cortex tumours ...
Insulinomas (largely benign) and gastrinomas are the most common types. For those with neuroendocrine cancers the number alive ...
Grant C (2005). "Insulinoma". Best Practice & Research Clinical Gastroenterology. 19 (5): 783-798. doi:10.1016/j.bpg.2005.05. ... insulinoma:[9] hypoglycemia occurs with concurrent elevations of insulin, proinsulin and C peptide[10] ... 45 but is generally avoided in insulinomas to avoid profound hypoglycemia.[6]:69 ...
Hypoglycemia-induced polyneuropathy is especially seen in conjunction with insulinoma. Myasthenia gravis Polyradiculoneuritis ...
... treatment increases insulin secretion in cultured insulinoma cells by increasing intracellular calcium mobilization. ...
He also is known for developing the diagnostic triad for insulinoma known as Whipple's triad. He supervised the surgical ...
"Sequence and functional expression in Xenopus oocytes of a human insulinoma and islet potassium channel". Proceedings of the ...
... from human insulinoma". DNA Cell Biol. 13 (5): 505-14. doi:10.1089/dna.1994.13.505. PMID 8024693. Cui L, Yu WP, DeAizpurua HJ, ...
... from human insulinoma". DNA Cell Biol. 13 (5): 505-14. doi:10.1089/dna.1994.13.505. PMID 8024693. "Entrez Gene: PTPRN protein ...
"Interferon-gamma induces transcription and differential expression of MHC genes in rat insulinoma cell line RINm5F". Diabetes. ...
An insulinoma is a tumor in the pancreas that produces too much insulin. ... Tumors of the pancreas that produce too much insulin are called insulinomas. Insulinomas keep making insulin, and can make your ... Insulinomas are very rare tumors. They usually occur as single, small tumors. But there can also be several small tumors. ... Surgery is the usual treatment for insulinoma. If there is a single tumor, it will be removed. If there are many tumors, part ...
An insulinoma is a tumor of the pancreas that is derived from beta cells and secretes insulin. It is a rare form of a ... An insulinoma removed from a woman in Munich provided insulin mRNA that was used in the first human gene cloning experiment. In ... Insulinoma is one of the most common types of tumors arising from the islets of Langerhans cells (pancreatic endocrine tumors ... Most insulinomas are small, less than 2 cm.[citation needed] Hypoglycemia was first recognized in the 19th century. In the ...
A Metastatic insulinoma is an extremely rare form of a malignant insulinoma involving metastatic growth. An insulinoma is a ... Malignant insulinoma is an extremely rare form of an insulinoma, affecting only about 10% of the total insulinoma cases. ... Metastatic insulinomas are even less prevalent than insulinomas, and commonly begin as benign insulinomas which metastasize ... Insulinomas tend to have a slightly higher prevalence in females, at about 59% of the total diagnosed general insulinoma cases ...
In a large single-center series of 125 patients with neuroendocrine tumors, insulinomas constituted the majority of cases (55 ... Insulinomas are the most common cause of hypoglycemia resulting from endogenous hyperinsulinism. ... Insulinomas can be located with the following imaging modalities:. * Endoscopic ultrasonography: Detects 77% of insulinomas in ... An insulinoma is a neuroendocrine tumor, deriving mainly from pancreatic islet cells, that secretes insulin. Some insulinomas ...
... Indian J Psychiatry. 2008 Jul;50(3):197-9. doi: 10.4103/0019-5545.43636. ... episode with intense sweating and clouding of consciousness was witnessed and helped in clinching the diagnosis of insulinoma. ...
A majority of sporadic insulinomas will be d... more ... of insulinomas in the pancreas.{ref3}{ref4}{ref5} The yield can ... Drugs & Diseases , Oncology , Insulinoma Q&A What is the role of ultrasonography in the diagnosis of insulinoma?. Updated: May ... Localization of Insulinoma Using 68Ga-DOTATATE PET/CT Scan. J Clin Endocrinol Metab. 2017 Jan 1. 102 (1):195-199. [Medline]. ... Insulinoma Detection With MDCT: Is There a Role for Whole-Pancreas Perfusion?. AJR Am J Roentgenol. 2017 Feb. 208 (2):306-314. ...
Insulinoma - Diagnosis and Treatment , IntechOpen, Published on: 2011-10-10. Authors: Jan Škrha, Jaroslava Dušková, Jan S ... Insulinoma - Diagnosis and Treatment. By Jan Škrha, Jaroslava Dušková, Jan Šváb, Jiřina Hilgertová, Josef Hořejš and ...
In a large single-center series of 125 patients with neuroendocrine tumors, insulinomas constituted the majority of cases (55 ... Insulinomas are the most common cause of hypoglycemia resulting from endogenous hyperinsulinism. ... encoded search term (Insulinoma) and Insulinoma What to Read Next on Medscape ... Recurrence of benign insulinomas was observed in 5.4% of patients in a series of 120 patients over a period of 4-17 years. The ...
Insulinoma is a very rare tumor in children and adolescents. Diagnosis of insulinoma is often delayed in this group of patients ... In children, pancreatic insulinomas are usually solitary and benign tumors. Prompt and early diagnosis of insulinoma is very ... Insulinoma is the most common neuroendocrine tumor of pancreas. Most insulinomas are solitary and sporadic, although about 10% ... Sporadic Insulinoma as a Rare Cause of Recurrent Hypoglycemia in Children. Hedyeh Saneifard,1 Ahmad Khaleghnejad Tabari,2 ...
What is an insulinoma, and how did I get it? A: An insulinoma is a pancreatic tumor. It produces too much insulin, resulting in ... My doctor ordered blood work, an EEG and a MRI, and sent me to a specialist, who diagnosed an insulinoma following a CT scan ... What is an insulinoma, and how did I get it?. A: An insulinoma is a pancreatic tumor. It produces too much insulin, resulting ... Family Doctor - What is an insulinoma?. Peter Gott, M.D. Tuesday. Aug 30, 2011 at 12:01 AM Aug 30, 2011 at 12:56 PM ...
Retrieved from "https://www.wikidoc.org/index.php/Special:Browse/:Insulinoma-5Fscreening" ...
Lin Li, Project Manager from BGI, said: "In this study, we conducted whole exome sequencing on sporadic insulinomas, and found ... The major genetic alterations in insulinomas are still unknown.. In this study, researchers identified T372R mutation in YY1 by ... Scientists Identified T372R Mutation As Potential Target For Diagnosis And Treatment Of Insulinoma. by editor ... Functional PNETs are mainly represented by insulinoma, which secrete insulin independent of glucose and cause hypoglycemia. ...
Insulinomas are the most common, functioning, pancreatic neuroendocrine tumours. The great majority (,90%) of insulinomas are ... New therapeutic options for metastatic malignant insulinomas.. de Herder WW1, van Schaik E, Kwekkeboom D, Feelders RA. ... An additional advantage of everolimus in the treatment of patients with metastatic insulinomas is its capability to increase ... In patients with metastatic insulinomas, this therapeutic modality was also effective in controlling hypoglycaemia, even in the ...
Insulinomas are the most common functioning pancreatic neuroendocrine tumors (NETs) and account for 20-30% of all pancreatic ... In contrast to all other pancreatic NETs, insulinomas are benign in more than 85% of patients, but, as in other NETs, the ... The diagnosis of insulinoma is established by demonstrating inappropriately high insulin concentrations during a spontaneous or ... After the diagnosis of insulinoma is established, an attempt should be made to locate and stage the tumor. (. Table 1. ) ...
Adrenomedullin, a new peptide, in patients with insulinoma.. [C Letizia, G Tamburrano, P Alo, A Paoloni, C Caliumi, E Marinoni ... Our findings indicate that circulating adrenomedullin is increased in insulinoma and that this increase is related to the ... The study was performed in nine patients with surgically treated insulinoma. Circulating adrenomedullin was assayed using a ... Adrenomedullin concentrations were significantly greater in patients with insulinoma (6.6 +/- 3.2 fmol/ml) than in controls ( ...
... Yavuz Savas Koca,1 ... The aim of imaging methods in insulinoma is to determine tumor localization and evaluate metastasis. Although insulinoma has a ... Insulinoma and other causes that give rise to hyperinsulinemia should not be ignored and these diagnoses should be excluded. In ... Currently, a mass of 12.5 × 11.6 mm is seen in head of pancreas (Figure 1). This mass was first considered as insulinoma and a ...
Global Insulinoma Treatment Market 2019-2023 , Strategic Alliances to Drive Growth , Technavio - read this article along with ... Global insulinoma treatment market: Technological advances in surgery. Insulinoma is caused by a small tumor in the pancreas ... Global insulinoma treatment market: Segmentation analysis. The global insulinoma treatment market research report provides ... Advances are being witnessed in insulinoma treatment due to the increasing awareness of neuroendocrine tumors and insulinoma. ...
RESULTS Insulinoma location were confirmed preoperatively in insulinoma patients and accepted laparoscopic therapy (13 patients ... Single Center Experience of Laparoscopic Theraphy for Insulinoma. Yu Wenbin, MD, PhD, Hu Sanyuan, MD, PhD, Zhang Guangyong, ... CONCLUSIONS When insulinoma diagnosis confirmed, localization could be made cooperatively by several relative examinations. ... Laparoscopic resection is a feasible and safe therapeutic method for insulinoma. It may decrease the postoperative pain of the ...
We recently have a case of insulinoma of the pancreas located at the upper margin of pancreatic neck and it was close to the ... Laparoscopic Enucleation of the Insulinoma of the Pancreas. Takeshi Naitoh, MD FACS, T Morikawa, MD, M Kakyo, MD, M Kinouchi, ...
Functional and Morphologic Characterization of Human Insulinomas. Michael Berger, Cesare Bordi, Hans-J Cüppers, Peter Berchtold ... Functional and Morphologic Characterization of Human Insulinomas. Michael Berger, Cesare Bordi, Hans-J Cüppers, Peter Berchtold ... Functional and Morphologic Characterization of Human Insulinomas Message Subject (Your Name) has forwarded a page to you from ... The proposed classification of human insulinomas in groups A and B, however, does not allow the assessment of the clinical or ...
... called insulinomas, make extra insulin, more than your body can use. This causes blood sugar levels to drop too low. This can ... What causes an insulinoma?. The cause of an insulinoma is unknown.. Who is at risk for an insulinoma?. There are few risk ... Can an insulinoma be prevented?. There are no known ways to prevent an insulinoma. You may want to be checked for an insulinoma ... Key points about insulinomas. * An insulinoma is a tumor in your pancreas. It makes extra insulin, more than your body can use. ...
insulinoma-associated protein 1 , zinc finger protein IA-1 , insulinoma-associated protein (IA-1) , insulinoma-associated 1 , ... Insulinoma-associated 1-like protein a , Zinc finger protein IA-1a , insulinoma-associated 1-like protein a , insulinoma- ... Insulinoma-Associated 1 (INSM1) Antigen-Profil Protein Überblick Insulinoma-associated 1 (INSM1) gene is intronless and encodes ... anti-Insulinoma-Associated 1 Antikörper Insulinoma-associated 1 (INSM1) gene is intronless and encodes a protein containing ...
I am ,b,undergoing tests for insulinoma,/b,. Is this a common disease? I am only 35 years old. ... Am I suffering from insulinoma?. Answered by: Prof Dinesh Dhanwal , Prof of Medicine and Head of Endocrinology,. Maulana Azad ... A:Insulinoma is a very rare disease. It is a small tumour of pancreas which produces excessive insulin leading on to low blood ... I am undergoing tests for insulinoma. Is this a common disease? I am only 35 years old. ...
An insulinoma was diagnosed in a fifty-seven-year-old woman suffering from frequent hypoglycemic attacks. Propranolol-a beta- ... Prevention of Hypoglycemic Attacks by Propranolol in a Patient Suffering from Insulinoma. ... Prevention of Hypoglycemic Attacks by Propranolol in a Patient Suffering from Insulinoma ... Prevention of Hypoglycemic Attacks by Propranolol in a Patient Suffering from Insulinoma ...
The poly-ADP-ribosylation (PARsylation) activity of tankyrase (TNKS) regulates diverse physiological processes including energy metabolism and wnt/β-catenin signaling. This TNKS activity uses NAD+ as a co-substrate to post-translationally modify various acceptor proteins including TNKS itself. PARsylation by TNKS often tags the acceptors for ubiquitination and proteasomal degradation. Whether this TNKS activity is regulated by physiological changes in NAD+ levels or, more broadly, in cellular energy charge has not been investigated. Because the NAD+ biosynthetic enzyme nicotinamide phosphoribosyltransferase (NAMPT) in vitro is robustly potentiated by ATP, we hypothesized that nutritional energy might stimulate cellular NAMPT to produce NAD+ and thereby augment TNKS catalysis. Using insulin-secreting cells as a model, we showed that glucose indeed stimulates the autoPARsylation of TNKS and consequently its turnover by the ubiquitin-proteasomal system. This glucose effect on TNKS is mediated primarily by
Insulinoma remains a rare entity with sometimes misleading absence of classic neuroglycopenic symptoms. Index of suspicion must ... In follow-up, the patient was found to have mild hyperglycemia, suggesting that the insulinoma may have been masking mild type ... Symptoms of hypoglycemia can become blunted with repeated episodes.1 For this reason, many patients with insulinoma gradually ... Mitrakou et al.2 have described lower scores for autonomic and neuroglycopenic symptoms in patients with insulinoma compared ...
Yet patients with insulinoma continue to baffle many medical specialists, who presumably are not sufficiently aware of the ... Insulinoma: poor recognition of clinical features is the major problem in diagnosis Med J Aust. 1978 Jul 1;2(1):1-5. doi: ... Yet patients with insulinoma continue to baffle many medical specialists, who presumably are not sufficiently aware of the ... It seems likely that a number of patients with insulinoma, whose symptoms are less dramatic than those reported here, are being ...
Insulinoma - Etiology, pathophysiology, symptoms, signs, diagnosis & prognosis from the Merck Manuals - Medical Professional ... Key Points about Insulinoma * Only about 10% of insulinomas are malignant, but all cause fasting hypoglycemia. ... Insulinomas are a type of pancreatic endocrine tumor that arises from islet cells. Of all insulinomas, 80% are single and may ... Only 10% of insulinomas are malignant. Insulinoma occurs in 1/250,000 at a median age of 50 years, except in multiple endocrine ...
Insulinoma and concurrent adrenal disease in a ferret. This ferret was in the end stages of both pancreatic and adrenal ...
... called insulinomas, make extra insulin, more than your body can use. This causes blood sugar levels to drop too low. This can ... Can an insulinoma be prevented?. There are no known ways to prevent an insulinoma. You may want to be checked for an insulinoma ... Key points about insulinomas. * An insulinoma is a tumor in your pancreas. It makes extra insulin, more than your body can use. ... Insulinoma. What is an insulinoma?. The pancreas makes insulin, which helps keep your blood sugar level balanced. If you have a ...
  • Insulinomas keep making insulin, and can make your blood sugar level too low (hypoglycemia). (medlineplus.gov)
  • citation needed] The diagnosis of insulinoma is suspected in a patient with symptomatic fasting hypoglycemia. (wikipedia.org)
  • Insulinomas are the most common cause of hypoglycemia resulting from endogenous hyperinsulinism. (medscape.com)
  • Failure of endogenous insulin secretion to be suppressed by hypoglycemia is the hallmark of an insulinoma. (medscape.com)
  • citation needed] Patients with an insulinoma initially exhibit symptoms of hypoglycemia resulting from excess insulin secretion from the islet beta cells within the pancreatic tumor or from non-pancreatic tumor cells. (wikipedia.org)
  • GLP-1 provoked severe hypoglycemia in an individual with type 2 diabetes and a benign insulinoma. (medscape.com)
  • In this case report, we present the case of a 10-year-old boy with signs and symptoms of hypoglycemia and final diagnosis of insulinoma. (hindawi.com)
  • Diagnosis of insulinoma is often delayed in this group of patients because neuropsychiatric signs and symptoms such as confusion, personality change, ataxia, and seizure that occur following hypersecretion of insulin by this tumor and consequent hypoglycemia and neuroglycopenia are commonly seen in a variety of other pediatrics diseases [ 1 , 2 ]. (hindawi.com)
  • Prompt and early diagnosis of insulinoma is very important because it can cause recurrent hypoglycemia which can consequently cause irreversible neurologic damage. (hindawi.com)
  • Functional PNETs are mainly represented by insulinoma, which secrete insulin independent of glucose and cause hypoglycemia. (redorbit.com)
  • Hypoglycemia in insulinoma patients is primarily due to reduced hepatic output, rather than increased glucose utilization. (renalandurologynews.com)
  • The diagnosis of insulinoma is established by demonstrating inappropriately high insulin concentrations during a spontaneous or induced episode of hypoglycemia (usually a 72-hour fast conducted under supervision). (renalandurologynews.com)
  • About 98% of patients with insulinoma develop symptomatic hypoglycemia during a 72-hour fast. (renalandurologynews.com)
  • Failure of appropriate insulin suppression in the presence of hypoglycemia confirms the presence of autonomous insulin secretion by an insulinoma. (renalandurologynews.com)
  • In cases that are assumed to be healthy, the most frequent causes of hypoglycemia are drugs, insulinoma, islet cell hyperplasia/nesidioblastosis, and factitious hypoglycemia due to surreptitious administration of insulin or sulfonylureas. (hindawi.com)
  • We, herein, report a patient who underwent gastrojejunostomy for duodenal ulcer and then developed symptomatic hypoglycemia because of insulinoma. (hindawi.com)
  • An insulinoma can cause low blood sugar (hypoglycemia). (stanfordchildrens.org)
  • Biochemical evidence of hypoglycemia with hyperin-sulinemia led to radiological investigation for an insulinoma. (diabetesjournals.org)
  • 1 For this reason, many patients with insulinoma gradually develop hypoglycemia unawareness. (diabetesjournals.org)
  • Surreptitious administration of exogenous insulin can cause episodic hypoglycemia mimicking insulinoma. (merckmanuals.com)
  • Hypoglycemia secondary to an insulinoma occurs during fasting. (merckmanuals.com)
  • Symptoms of hypoglycemia due to insulinoma are insidious and may mimic various psychiatric and neurologic disorders. (merckmanuals.com)
  • Because many patients have no symptoms (and hence no hypoglycemia) at the time of evaluation, diagnosis of insulinoma requires admission to the hospital for a 48- or 72-hour fast. (merckmanuals.com)
  • Insulinomas continue to release insulin despite hypoglycemia → continued tissue utilization of glucose → worsening hypoglycemia. (vetstream.com)
  • Insulinoma is a clinically common cause of organic hypoglycemia. (elsevier.com)
  • The diagnosis of insulinoma is established by demonstrating inappropriately high serum insulin concentrations during a spontaneous or induced episode of hypoglycemia. (snmjournals.org)
  • The common clinical manifestations of insulinoma are fasting hypoglycemia and neuroglycopenic symptoms. (snmjournals.org)
  • The diagnosis of insulinoma is established by demonstrating inappropriately high serum insulin concentrations during a spontaneous or induced episode of hypoglycemia (72-h fast). (snmjournals.org)
  • All 3 patients had fasting hypoglycemia and received a biochemical diagnosis of insulinoma when they experienced inappropriately high serum insulin concentrations during a 72-h fast. (snmjournals.org)
  • Insulinoma is a rare functioning pancreatic endocrine tumor, typically presenting as a sporadic solitary lesion causing hypoglycemia. (myjournals.org)
  • Insulinomas can cause hypoglycemia, or low blood sugar. (staywellsolutionsonline.com)
  • Diagnosis of an insulinoma in adult patients with confirmed orfsuspicious symptoms related to hypoglycemia has to be of prime concern in the differential diagnosis of hypoglycemia . (findmedarticle.com)
  • 19(6): 829-837 Available from: URL: http://www.wjgnet.com/1007-9327/full/v19/ i6/829.htm DOI: http://dx.doi.org/10.3748/wjg.v19.i6.829 Insulinomas, the most common cause of hypoglycemia related to endogenous hyperinsulinism, occur in 1-4 people per million of the general population. (spotidoc.com)
  • We report a 59-year-old woman with hypoglycemia who initially developed parasomnia mimic symptoms in early morning sleep period and the final diagnosis was insulinoma. (e-jsm.org)
  • Persistent hyperinsulinemic hypoglycemia in adults is most commonly caused by insulinomas, which pose a diagnostic challenge to physicians, surgeons, and radiologists and require multimodality imaging for precise localization and staging. (rare-cancer.org)
  • The initial symptoms of canine insulinoma appear due to chronic hypoglycemia. (myanimals.com)
  • An insulinoma is a tumor in the pancreas that produces too much insulin. (medlineplus.gov)
  • An insulinoma is a tumor of the pancreas that is derived from beta cells and secretes insulin. (wikipedia.org)
  • Insulinomas are one of the functional pancreatic neuroendocrine tumor (PNET) group ("functional" because it increases production of insulin). (wikipedia.org)
  • The diagnosis of an insulinoma is usually made biochemically with low blood glucose, elevated insulin, proinsulin, and C-peptide levels, and confirmed by localizing the tumor with medical imaging or angiography. (wikipedia.org)
  • An endoscopic ultrasound has a sensitivity of 40-93% (depending on the location of the tumor) for detecting insulinomas. (wikipedia.org)
  • citation needed] During surgery to remove an insulinoma, an intraoperative ultrasound can sometimes localize the tumor, which helps guide the surgeon in the operation and has a higher sensitivity than noninvasive imaging tests. (wikipedia.org)
  • An insulinoma is a small tumor localized to the pancreas, originating from islet beta cells, which produce an excess of insulin. (wikipedia.org)
  • Cytoreductive surgery Diazoxide & Thiazide Diuretics Beta-Blockers Cytoreductive surgery, alongside other anti-tumor therapies are part of the initial treatment plans utilized for potential removal of the insulinoma. (wikipedia.org)
  • After insulinoma resection, hyperglycemia may persist for 48-72 hours because of chronic down-regulation of insulin-receptors by the previously high circulating insulin levels secreted by the tumor and the suppression of normal pancreatic B cells. (medscape.com)
  • [ 64 ] Note that some insulinomas are indolent (depending on the tumor biology), resulting in prolonged survival. (medscape.com)
  • Insulinoma is a rare pancreatic tumor in children and adolescents. (hindawi.com)
  • According to rarity of this tumor in children and nonspecificity of clinical presentations, diagnosis of insulinoma in this group of patients is usually delayed. (hindawi.com)
  • My doctor ordered blood work, an EEG and a MRI, and sent me to a specialist, who diagnosed an insulinoma following a CT scan that showed a tumor on the head of my pancreas. (cantonrep.com)
  • A: An insulinoma is a pancreatic tumor. (cantonrep.com)
  • Insulinomas are rare and typically occur as a single, small tumor in adults but can, very rarely, occur in children. (cantonrep.com)
  • After the diagnosis of insulinoma is established, an attempt should be made to locate and stage the tumor. (renalandurologynews.com)
  • Insulinoma is caused by a small tumor in the pancreas that produces extra insulin. (biospace.com)
  • The best treatment for insulinoma among the available treatment options is the surgical removal of the tumor. (biospace.com)
  • If you have a tumor on your pancreas called an insulinoma, it makes extra insulin. (stanfordchildrens.org)
  • An insulinoma is a tumor in your pancreas. (stanfordchildrens.org)
  • An insulinoma is a rare pancreatic beta-cell tumor that hypersecretes insulin. (merckmanuals.com)
  • Insulinomas are a type of pancreatic endocrine tumor that arises from islet cells. (merckmanuals.com)
  • Insulinomas represent 70% of islet cell tumors of pancreas and are the most common type of pancreatic neuro-endocrine tumor, with an annual incidence of 1-4 cases per million people. (radiopaedia.org)
  • Message encoding the β3 subunit is found in rat insulinoma tumor (RINm5f) cells and adrenal chromaffin cells, both of which express inactivating BK channels. (jneurosci.org)
  • Return of -adrenergic sensitivity in a patient with insulinoma after removal of the tumor. (medigraphic.com)
  • Although majority of the insulinomas are benign, over-secretion of insulin by the tumor leads to debilitating hypoglycemic symptoms. (springermedizin.de)
  • 2006) Well-differentiated pancreatic tumor/carcinoma: insulinoma. (springermedizin.de)
  • In general an Insulinoma is a neuroendocrine tumor which is rare. (checkdiabetes.org)
  • Insulinoma is a tumor found in the islets of Langerhans cells located in the pancreas. (checkdiabetes.org)
  • Because previous imaging was unable to localize the tumor, Volume Perfusion CT (VPCT) of the pancreas was ordered by the clinician for insulinoma localization. (siemens-healthineers.com)
  • Insulinoma - a tumor growing from the β-cells.Causes of the disease are unknown. (vitamedd.com)
  • Standard imaging studies (computed tomography, magnetic resonance imaging, somatostatin receptor scintigraphy, ultrasonography, and angiography) correctly localize insulinomas in less than 50% of patients and provide no information about the feasibility of enucleation based on proximity of tumor to pancreatic duct. (for-surgeons.com)
  • After an insulinoma is biochemically proven and after exclusion of a malignant metastasizing tumor by ultrasonography, all patients should be operated on. (for-surgeons.com)
  • Insulinomas are very difficult to diagnose and locate and so far they have not been able to locate a new tumor but do suspect there is regrowth of an old tumor or growth of a new one. (mayoclinic.org)
  • Insulinoma is a type of pancreatic neuroendocrine tumor (pancreatic NET), which refers to a group of rare tumors that form in the hormone -making cells of the pancreas. (rareidnews.com)
  • Surgical resection is the primary treatment modality for insulinomas, and so accurate localization of the tumor before or during surgery is important. (spotidoc.com)
  • Given the clinical history, the overall findings were consistent with functioning pancreatic neuroendocrine tumor (PanNET), insulinoma. (jpatholtm.org)
  • Canine insulinoma is a rare type of pancreatic tumor , but with a high fatality rate. (myanimals.com)
  • The tumor characteristic of insulinoma causes hypersecretion of this hormone. (myanimals.com)
  • Tumors of the pancreas that produce too much insulin are called insulinomas. (medlineplus.gov)
  • In rare cases, the entire pancreas is removed if there are many insulinomas or they continue to come back. (medlineplus.gov)
  • Most insulinomas are benign in that they grow exclusively at their origin within the pancreas, but a minority metastasize. (wikipedia.org)
  • Endoscopic ultrasonography detects 77% of insulinomas in the pancreas. (medscape.com)
  • CT scan revealed 7.6 × 13 mm solitary and enhancing lesion at the neck of pancreas in favour of insulinoma (Figures 1 and 2 ). (hindawi.com)
  • We recently have a case of insulinoma of the pancreas located at the upper margin of pancreatic neck and it was close to the splenic artery above the portal vein. (sages.org)
  • If the insulinoma is too small to be seen with these imaging tests, you may need tests that sample blood from multiple areas of your pancreas. (stanfordchildrens.org)
  • A small, single insulinoma at or near the surface of the pancreas can usually be enucleated surgically. (merckmanuals.com)
  • An insulinoma is a type of tumour that occurs in the pancreas. (yourhormones.info)
  • An insulinoma is a type of tumour called a neuroendocrine tumour (NET) that arises from the beta cells of the pancreas and causes problems by secreting too much insulin. (yourhormones.info)
  • Occasionally, insulinomas may spread and develop secondary tumours beyond the pancreas, most often affecting the liver. (yourhormones.info)
  • Computerised tomography ( CT ) or magnetic resonance imaging ( MRI ) scans are used to look for insulinomas in the pancreas and liver and to locate their exact position. (yourhormones.info)
  • a procedure known as a calcium stimulation test can be used to confirm that the insulinoma is in the pancreas and actively secreting insulin. (yourhormones.info)
  • An unusual case of insulinoma is described in a 40-yr-old woman whose resected pancreas showed multiple adenomas with lymph node metastasis, associated hyperplasia of islets, and nesidioblastosis. (diabetesjournals.org)
  • Insulinomas are rare endocrine tumors of the pancreas. (scirp.org)
  • Insulinomas are rare neuroendocrine tumors which occur predominantly in the pancreas. (springermedizin.de)
  • In all 3 patients, insulinoma was clearly shown on 68 Ga-DOTATATE PET/CT: at the body of the pancreas in patient 1 ( Fig. 1 ), at the body of the pancreas in patient 2 ( Fig. 2 ), and at the tail of the pancreas in patient 3 ( Fig. 3 ). (snmjournals.org)
  • Tumors on your pancreas, called insulinomas, make extra insulin, more than your body can use. (staywellsolutionsonline.com)
  • Insulinomas are tumors in your pancreas. (staywellsolutionsonline.com)
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  • Insulinomas are rare tumours that start in the insulin making cells of the pancreas. (cancerresearchuk.org)
  • Intraoperative manual palpation of the pancreas by an experienced surgeon and intraoperative ultrasonography are both sensitive methods with which to finalize the location of insulinomas. (spotidoc.com)
  • In patients with unresectable or uncontrollable insulinomas, such as malignant insulinoma of the pancreas, several techniques should be considered, including administration of ocreotide and/or continuous glucose monitoring, to prevent hypoglycemic episodes and to improve quality of life. (spotidoc.com)
  • www.wjgnet.com INTRODUCTION Insulinomas are the most common functioning endocrine neoplasm of the pancreas[1-4]. (spotidoc.com)
  • Insulinomas are evenly distributed over the entire pancreas. (spotidoc.com)
  • Most insulinomas are located in the pancreas or are attached directly to the pancreas. (spotidoc.com)
  • Intraoperative manual palpation of the pancreas by an experienced surgeon and intraoperative ultrasonography are both sensitive methods with which to localize insulinomas, supporting the argument by some surgeons that preoperative localization of the tumors is not necessary[29-33]. (spotidoc.com)
  • Localisation studies including magnetic resonance imaging (MRI), endoscopic ultrasound (EUS) and gallium dotatate positron emission tomography ( 68 Ga Dotatate PET) were consistent with a small insulinoma in the mid-body of the pancreas. (bioscientifica.com)
  • Insulinomas are the most common islet cell tumors and are located almost exclusively in the pancreas. (elsevier.com)
  • Insulinomas are very rare tumors. (medlineplus.gov)
  • Most insulinomas are non-cancerous (benign) tumors. (medlineplus.gov)
  • In contrast, the secretion of insulin by insulinomas is not properly regulated by glucose, and the tumors continue to secrete insulin causing glucose levels to fall further than normal. (wikipedia.org)
  • An indium-111 pentetreotide scan is more sensitive than ultrasound, CT, or MRI for detection of somatostatin receptor positive tumors, but not a good diagnostic tool for insulinomas. (wikipedia.org)
  • Insulinomas are commonly benign tumors, but can metastasize and become malignant. (wikipedia.org)
  • In children, pancreatic insulinomas are usually solitary and benign tumors. (hindawi.com)
  • Chinese researchers from Rui-Jin Hospital, Shanghai Jiao-Tong University School of Medicine, BGI and other institutes identified the recurrent T372R mutation in the transcription factor YY1 (Yin Yang 1) are related with insulinoma oncogenesis, implicating a potential marker for the diagnosis and treatment of functional pancreatic neuroendocrine tumors (PNETs). (redorbit.com)
  • Insulinomas are the most common functioning pancreatic neuroendocrine tumors (NETs) and account for 20-30% of all pancreatic NETs. (renalandurologynews.com)
  • CGA is usually elevated in gastroenteropancreatic neuroendocrine tumors (GEP-NETs), including insulinomas. (renalandurologynews.com)
  • Advances are being witnessed in insulinoma treatment due to the increasing awareness of neuroendocrine tumors and insulinoma. (biospace.com)
  • Circulating levels of insulin, proinsulin-like component, glucagon, growth hormone, and pancreatic polypeptide were measured in 12 patients with functioning insulinomas, and the suppressibility of serum insulin by somatostatin and diazoxide was assessed before surgical removal of the tumors. (diabetesjournals.org)
  • The proposed classification of human insulinomas in groups A and B, however, does not allow the assessment of the clinical or histopathologic malignancy of the tumors. (diabetesjournals.org)
  • Laparoscopic ultrasonography as a diagnostic tool for the localization of islet cell tumors has been described before, but few reports on laparoscopic resection of insulinomas exist. (eur.nl)
  • Enhancement of various M2 effecter cytokines and angiogenic reprogramming in iNOs+ macrophage depleted tumors and their subsequent reduction by 2 Gy dose in Rip1-Tag5 transgenic mice furthermore demonstrated a critical role of peritumoral macrophages in the course of gamma irradiation mediated M1 retuning of insulinoma. (ovid.com)
  • Most insulinoma tumors in humans as well as animals are usually benign meaning non-cancerous. (checkdiabetes.org)
  • Insulinomas are rare pancreatic endocrine tumors. (biomedcentral.com)
  • Among pancreatic endocrine tumors, insulinoma is the most common type. (biomedcentral.com)
  • Most insulinomas are islet-cell tumors. (snmjournals.org)
  • Accurate preoperative localization of an insulinoma is desirable because some tumors may not be palpable at the time of surgery ( 1 ). (snmjournals.org)
  • However, people with specific genetic syndromes such as multiple endocrine neoplasia type I , Von Hippel-Lindau syndrome , Neurofibromatosis type 1 , and tuberous sclerosis are at risk of insulinomas and other endocrine tumors . (rareidnews.com)
  • Glucagon-like peptide 1 receptor analogs have recently shown promising results in preoperative localization of these tumors, as all insulinomas express glucagon-like peptide 1 receptors. (rare-cancer.org)
  • This case report discusses an uncommon and challenging case of insulinoma soon after upper gastrointestinal surgery. (bioscientifica.com)
  • 68Ga-DOTA-Exendin PET-MRI Fusion Imaging in a Case of Insulinoma. (rare-cancer.org)
  • The incidence of insulinoma is higher in adults and diagnostic criteria are more clearly defined. (hindawi.com)
  • Venous glucose concentration of less than 45 mg/dL with a simultaneous serum insulin concentration greater than 6 μU/mL is diagnostic for insulinoma. (renalandurologynews.com)
  • This is an open-label positron emission tomography/computed tomography (PET/CT) study to investigate the diagnostic performance and evaluation efficacy of 68Ga-NOTA-exendin-4 in insulinoma and nesidioblastosis patients. (clinicaltrials.gov)
  • The investigators will determine the use of 68Ga-NOTA-exendin-4 PET/CT in the detection of insulinomas, and to compare its diagnostic value with conventional imaging. (clinicaltrials.gov)
  • Because of its deceptive, disguising and nonpathognomonic symptomatology, insulinoma can pose a diagnostic dilemma even to a shrewd clinician and remain undiagnosed for years. (org.pk)
  • 2000) Forty-eight-hour fast: the diagnostic test for insulinoma. (springermedizin.de)
  • Insulinoma remains a diagnostic challenge to practitioners. (biomedcentral.com)
  • Insulinoma: case report and review of diagnostic and treatment modalities. (5minuteconsult.com)
  • However, blood glucose level alone is not diagnostic of insulinoma. (news-medical.net)
  • A Metastatic insulinoma is an extremely rare form of a malignant insulinoma involving metastatic growth. (wikipedia.org)
  • Metastatic insulinomas are commonly preceded by hypoglycemic symptoms and the Whipple triad. (wikipedia.org)
  • This is primarily attributed to the fact that metastatic insulinoma is initially diagnosed as another disease, such as benign insulinoma, which has the potential to progress and metastasize[citation needed] Insulinomas generally occur sporadically. (wikipedia.org)
  • To date, the current cause of metastatic insulinomas is unknown. (wikipedia.org)
  • Metastatic insulinomas are even less prevalent than insulinomas, and commonly begin as benign insulinomas which metastasize into metastastic insulinoma. (wikipedia.org)
  • In metastatic insulinoma, cancerous cells from the initial insulinoma begin to break away and enter into either the bloodstream or the lymphatic system. (wikipedia.org)
  • Upon completion of bloodwork and required radiology, majority of metastatic insulinomas are diagnosed if present. (wikipedia.org)
  • But, some of these patient cases progress and metastasize into a metastatic insulinoma. (wikipedia.org)
  • However, the second type of diagnoses of metastatic insulinoma involves a patient who presents with symptoms of an insulinoma, and is taken for a pre-operative CT. (wikipedia.org)
  • Upon reading the radiology report, a metastatic insulinoma can be found and diagnosed immediately. (wikipedia.org)
  • But, in those patients with metastatic insulinoma surgery is not enough. (wikipedia.org)
  • Patients may develop nonfunctioning metastatic disease to the liver up to 14 years after insulinoma resection. (medscape.com)
  • New therapeutic options for metastatic malignant insulinomas. (nih.gov)
  • An additional advantage of everolimus in the treatment of patients with metastatic insulinomas is its capability to increase blood glucose levels. (nih.gov)
  • In patients with metastatic insulinomas, this therapeutic modality was also effective in controlling hypoglycaemia, even in the presence of tumour regrowth. (nih.gov)
  • With the introduction of these new therapeutic modalities, the therapeutic arsenal for the 'tailor-made' approach of patients with metastatic insulinomas is further expanded. (nih.gov)
  • In this report US, CT, and single-photon emission computed tomography (SPECT) with [111In-DTPA-D-Phe1]-octreotide (a specific form of SRS) were compared for their effectiveness in detecting and localizing primary and metastatic insulinoma in dogs. (avmi.net)
  • The authors identified 10 patients with metastatic insulinoma. (elsevier.com)
  • The current study, as well as others, suggested that metastatic insulinoma may have a variable natural history. (elsevier.com)
  • Malignant metastatic insulinoma - postoperative treatment and follow-up. (deathtoall.info)
  • Insulinoma is a rare pancreatic endocrine tumour with an incidence of four cases per million per year. (jcdr.net)
  • Henquin JC, Nenquin M, Guiot Y, Rahier J, Sempoux C. Human Insulinomas Show Distinct Patterns of Insulin Secretion In Vitro. (medscape.com)
  • This way of separating human insulinomas in groups A and B represents a simplification of existing classifications and emphasizes the quantitative ultrastructure in relationship to suppressibility of insulin secretion. (diabetesjournals.org)
  • Transcripts of calcium/calmodulin-dependent kinases are changed after forskolin- or IBMX-induced insulin secretion due to melatonin treatment of rat insulinoma beta-cells (INS-1). (semanticscholar.org)
  • The genes involved in the protein/insulin secretion pathway were strongly expressed in human insulinoma tissue. (elsevier.com)
  • Non-invasive imaging procedures, such as computed tomography and magnetic resonance imaging, are used when a diagnosis of insulinoma has been made to localize the source of pathological insulin secretion. (spotidoc.com)
  • In this study, we investigated the effects of exposure to an extremely low frequency magnetic field (ELFMF) on hormone secretion from an islet derived insulinoma cell line, RIN-m. (stetzerelectric.com)
  • In conclusion, the predominance of the genes participating in the secretory pathway suggested that regulation of secretion might be a major mechanism by which insulin release is abnormally increased in patients with insulinomas. (elsevier.com)
  • citation needed] The definitive management is surgical removal of the insulinoma. (wikipedia.org)
  • The most common treatment option for those diagnosed with benign insulinomas are treated by isolated removal of the insulinoma. (wikipedia.org)
  • Thus, it is possible to later develop malignancy after the initial diagnosis of insulinoma, and even after operative removal of the insulinoma. (wikipedia.org)
  • citation needed] Patients who are diagnosed with general insulinoma are commonly treated with surgical removal of the insulinoma. (wikipedia.org)
  • Laparoscopic ultrasonography followed by laparoscopic removal of the insulinoma in patients with clinically manifested hyperinsulinism is a feasible and safe technique with low morbidity and fast postoperative recovery. (eur.nl)
  • The prominent characteristic of insulinoma is endogenous hyperinsulinism. (elsevier.com)
  • Insulinoma is usually detected early in the disease course as a benign form due to clinical manifestations associated with hyperinsulinism [ 1 ]. (jpatholtm.org)
  • What is the role of ultrasonography in the diagnosis of insulinoma? (medscape.com)
  • Endoscopic ultrasonography in a patient with an insulinoma. (medscape.com)
  • Kirkeby H, Vilmann P, Burcharth F. Insulinoma diagnosed by endoscopic ultrasonography-guided biopsy. (medscape.com)
  • Noninvasive imaging of insulinomas and gastrinomas with endoscopic ultrasonography and somatostatin receptor scintigraphy. (medscape.com)
  • In this paper, 71-year-old male patient who was followed up for 2 years with a false conclusion of dumping syndrome and operated on due to insulinoma diagnosed at endoscopic ultrasonography is presented in the light of the literature. (hindawi.com)
  • Laparoscopic ultrasonography was performed to localize the insulinoma and then laparoscopic resection was performed. (eur.nl)
  • Laparoscopic ultrasonography could identify an insulinoma in 90% of the patients (9/10 patients). (eur.nl)
  • Jaroszewski D, Schlinkert R, Thompson G, Schlinkert D. Ultrasonography localization and resection of insulinomas. (medigraphic.com)
  • Does conventional abdominal preoperative ultrasonography have a role in the detection of pancreatic insulinoma? (scirp.org)
  • In dogs with insulinoma, preoperative assessment usually is performed with transabdominal ultrasonography (US). (avmi.net)
  • Insulinomas can be detected using either noninvasive procedures (e.g., transabdominal ultrasonography, spiral CT, MRI, 111 In-pentetreotide imaging, and 18 F- l -dihydroxyphenylalanine PET) or invasive procedures (e.g., endoscopic ultrasonography) or a selective arterial calcium stimulation test with hepatic venous sampling. (snmjournals.org)
  • Invasive modalities, such as endoscopic ultrasonography and arterial stimulation venous sampling, are highly accurate in the preoperative localization of insulinomas and have frequently been shown to be superior to noninvasive localization techniques. (spotidoc.com)
  • Therefore, clinical appearance and pathology are not sufficient in diagnosing a malignant insulinoma. (wikipedia.org)
  • Yet patients with insulinoma continue to baffle many medical specialists, who presumably are not sufficiently aware of the clinical features of hypoglycaemia. (nih.gov)
  • We identified 5 cases that were confirmed on clinical, biochemical or histopathological bases and were recorded on the histopathology and IT database as insulinoma from 1986 to 2004. (endocrine-abstracts.org)
  • 1 Allen Oldfather Whipple proposed the classic clinical criteria for diagnosis of insulinoma (eponymously known as Whipple's triad) and Graham (1929) successfully removed insulinoma. (org.pk)
  • The aim of reporting this case is to create clinical awareness among the healthcare professionals in order to avoid occurrence of a serious mistake in the diagnosis and treatment of insulinoma. (org.pk)
  • Frequency and clinical correlates of somatic Ying Yang 1 mutations in sporadic insulinomas. (semanticscholar.org)
  • A majority of sporadic insulinomas will be detected and localized by a combination of these two investigative means. (medscape.com)
  • In this study, researchers identified T372R mutation in YY1 by whole exome sequencing of 10 sporadic insulinomas samples. (redorbit.com)
  • Lin Li, Project Manager from BGI, said: "In this study, we conducted whole exome sequencing on sporadic insulinomas, and found the hotspot mutations of T372R in 30% insulinomas. (redorbit.com)
  • A prospective evaluation of intraoperative ultrasound as a technique for localizing sporadic insulinomas. (medigraphic.com)
  • Apart from hereditary forms such as multiple endocrine neoplasia type 1 (MEN-1), genetic causes for sporadic insulinoma development had remained obscure until recently. (semanticscholar.org)
  • Most are sporadic, however, 10 % of insulinomas are multiple and occur as part of multiple endocrine neoplasia syndrome type I (MEN-I). Because of nonspecific symptoms, insulinoma may be misdiagnosed with other disorders. (biomedcentral.com)
  • Defines the incidence and long-term outcome of sporadic and multiple endocrine neoplasia type MEN -1 associated insulinoma. (deathtoall.info)
  • But, once diagnosed malignant insulinomas are not easily treated. (wikipedia.org)
  • In patients with malignant insulinomas, an aggressive medical approach, including extended pancreatic resection, liver resection, liver transplantation, chemoembolization, or radiofrequency ablation, is recommended to improve both survival and quality of life. (spotidoc.com)
  • RESULTS Insulinoma location were confirmed preoperatively in insulinoma patients and accepted laparoscopic therapy (13 patients underwent laparoscopic enucleation of the insulinoma, 4 patients underwent laparoscopic distal pancreatectomy, one patient accepted hand assisted laparoscopic uncinate insulinoma resection, 3 patients converted to laparotomy). (sages.org)
  • She underwent enucleation of the mass, and the surgical pathology was consistent with insulinoma. (diabetesjournals.org)
  • In 6 patients the insulinoma could be resected laparoscopically, either by enucleation (5 patients) or by resection of the pancreatic tail (1 patient). (eur.nl)
  • Open procedure surgery was done for the two patients and insulinomas were successfully removed by enucleation. (biomedcentral.com)
  • Laparoscopic ultrasound and enucleation/resection may be increasingly used in the management of patients with insulinoma. (elsevier.com)
  • citation needed] Most patients with benign insulinomas can be cured with surgery. (wikipedia.org)
  • Recurrence of benign insulinomas was observed in 5.4% of patients in a series of 120 patients over a period of 4-17 years. (medscape.com)
  • 68 Ga-DOTATATE PET/CT imaging may be a useful noninvasive imaging technique to localize insulinomas preoperatively. (snmjournals.org)
  • Before re-operations one should consider the use of costly pre-operative methods to localize insulinomas. (for-surgeons.com)
  • This occurs when cancerous cells break away from the insulinoma and enter the bloodstream or lymphatic system. (wikipedia.org)
  • Sensitivity to dihydropyridines, omega-conotoxin and noradrenaline reveals multiple high-voltage-activated Ca2+ channels in rat insulinoma and human pancreatic beta-cells. (nih.gov)
  • High-voltage-activated (HVA) Ba2+ currents of rat insulinoma (RINm5F) and human pancreatic beta-cells were tested for their sensitivity to dihydropyridines (DHPs), omega-conotoxin (omega-CgTx) and noradrenaline. (nih.gov)
  • The octreotide sticks to the insulinoma cells so the doctor can then use a scanner to identify where the octreotide is and therefore where the insulinoma cells are. (yourhormones.info)
  • Stable expression of manganese superoxide dismutase (MnSOD) in insulinoma cells prevents IL-1beta- induced cytotoxicity and reduces nitric oxide production. (jci.org)
  • In the current study, we show that IL-1beta induces destruction of INS-1 insulinoma cells, while having no effect on a second insulinoma cell line RIN1046-38 and its engineered derivatives, and that this difference is correlated with a higher level of expression of manganese superoxide dismutase (MnSOD) in the latter cells. (jci.org)
  • One of the most common and most devastating of ferret diseases is cancer of the insulin-producing cells called an insulinoma. (drexotic.com)
  • To gain insight into the mitochondrial-mediated mechanisms by which long-term exposure of INS-1 cells to excess FFAs causes β-cell dysfunction, the effects of the unsaturated FFA linoleic acid (C 18:2, n-6) on rat insulinoma INS-1 β cells was investigated. (eurekamag.com)
  • When there is an insulinoma the beta cells continue secreting insulin and the blood glucose continues to drop lower than the normal level. (checkdiabetes.org)
  • This study investigates the occurrence and regulation of serine/threonine protein phosphatases (PPases) in insulin-secreting RINm5F insulinoma cells. (bioscirep.org)
  • Ca2+/calmodulin-dependent protein kinase II delta2 regulates gene expression of insulin in INS-1 rat insulinoma cells. (semanticscholar.org)
  • Calcium-signaling components in rat insulinoma β-cells (INS-1) and pancreatic islets are differentially influenced by melatonin. (semanticscholar.org)
  • La media en la Neck Disability Index al inicio fue de P0 is synthesized by Schwann cells, processed in the endoplasmic reticulum ER and enters the secretory pathway. (deathtoall.info)
  • By measuring mitochondrial bioenergetics in attached INS-1E insulinoma cells with and without UCP2, we show that UCP2 contributes to proton leak and attenuates glucose-induced rises in both respiratory activity and the coupling efficiency of oxidative phosphorylation. (deathtoall.info)
  • Insulinomas, specifically, produce too much insulin, a hormone that reduces the level of sugar in the blood by helping it move into cells. (rareidnews.com)
  • Huai JC, Zhang W, Niu HO, Su ZX, Mcnamara JJ, Machi J. Localization and surgical treatment of pancreatic insulinomas guided by intraoperative ultrasound. (medigraphic.com)
  • Preoperative and intraoperative topographic diagnosis of insulinomas. (medscape.com)
  • Different preoperative and intraoperative imaging techniques have been used with varying success rates for the insulinoma imaging. (springermedizin.de)
  • 1986) Benign pancreatic insulinoma: preoperative and intraoperative sonographic localization. (springermedizin.de)
  • These blood tests are needed to diagnose insulinoma:[citation needed] glucose insulin C-peptide If available, a proinsulin level might be useful, as well. (wikipedia.org)
  • Insulin, proinsulin, and C-peptide levels were again elevated and similar to the previous values, and beta-hydroxybutyrate was suppressed, suggesting insulinoma. (diabetesjournals.org)
  • In patients with insulinoma, C peptide is ≥ 0.6 ng/mL (0.2 nmol/L) and proinsulin is ≥ 5 pmol/L. These levels are normal or low in patients with surreptitious insulin administration. (merckmanuals.com)
  • Insulinoma: pathophysiology, localization and management. (medscape.com)
  • In this manuscript, we report 2 cases of pancreatic insulinoma, and we discuss diagnosis, localization and management of this uncommon disease. (biomedcentral.com)
  • Our findings indicate that circulating adrenomedullin is increased in insulinoma and that this increase is related to the neoplastic phenotype. (sigmaaldrich.com)
  • These findings suggest that none of the tests performed were able to localize insulinoma accurately all the time. (endocrine-abstracts.org)
  • Diagnosis and localisation of insulinoma: the value of modern magnetic resonance imaging in conjunction with calcium stimulation catheterisation. (radiopaedia.org)
  • We looked at the number of investigations performed before exact localisation of insulinoma. (endocrine-abstracts.org)
  • ERCP is not indicated in the preoperative localisation of insulinomas. (for-surgeons.com)
  • Abnormal nocturnal behaviors persist long duration in the fasting state or early morning, are considered as hypoglycemic symptoms of insulinoma. (e-jsm.org)
  • Patients with insulinomas usually develop neuroglycopenic symptoms. (wikipedia.org)
  • Neuroglycopenic and other symptoms in patients with insulinomas. (medscape.com)
  • People with certain genetic disorders, such as multiple endocrine neoplasia type I , are at higher risk for insulinomas. (medlineplus.gov)
  • Insulinoma occurs in 1/250,000 at a median age of 50 years, except in multiple endocrine neoplasia (MEN) type 1 (about 10% of insulinomas), when it occurs in the 20s. (merckmanuals.com)
  • It is unclear why insulinomas occur in most cases, although some occur as part of a genetic condition called multiple endocrine neoplasia type 1 . (yourhormones.info)
  • For 1 in 14 patients, the insulinoma may be part of an inherited syndrome called multiple endocrine neoplasia type 1. (yourhormones.info)
  • OBJECTIVES: To identify gene expression alterations associated with insulinoma formation and progression in 2 mouse models of multiple endocrine neoplasia type 1. (ox.ac.uk)
  • Insulinomas, although rare, are the most common functioning pancreatic islet cell tumour and may be part of the multiple endocrine neoplasia type 1 (MEN 1) syndrome. (oxfordmedicine.com)
  • A 33-year-old male with an insulinoma, who had been hypoglycemic during the previous four years, developed abnormally elevated levels of liver enzymes and histological fatty liver characteristic of NAFLD by the time of admission to our hospital for resection of an insulinoma. (go.jp)
  • A 60-yr-old, 98-kg, white man presented to the operating room for a laparoscopic resection of an insulinoma. (asahq.org)
  • She has the BIOCHEMICAL diagnosis of insulinoma, but not the ANATOMICAL one. (for-surgeons.com)
  • Selective intra-arterial calcium stimulation with hepatic venous sampling for preoperative localization of insulinomas. (biomedsearch.com)
  • OBJECTIVE: To determine the value of selective intra-arterial calcium stimulation with hepatic venous sampling using serum insulin and C-peptide gradients for the preoperative localization of insulinomas. (biomedsearch.com)
  • CONCLUSION: Selective intra-arterial calcium stimulation with hepatic venous sampling is a highly accurate and safe method for the preoperative localization of insulinomas. (biomedsearch.com)
  • In order to diagnose an insulinoma, patients suspected of the disease are usually admitted to hospital to undergo a supervised 72-hour fast. (yourhormones.info)
  • Laparoscopic surgery is being used for treating insulinoma owing to the recent developments in technology. (biospace.com)
  • OBJECTIVE To investigate the feasibility and safety for laparoscopic therapy to insulinoma. (sages.org)
  • Laparoscopic resection is a feasible and safe therapeutic method for insulinoma. (sages.org)
  • We retrospectively reviewed the results of our experience with laparoscopic detection and the resection of insulinomas to determine its feasibility. (eur.nl)
  • Thirty-five patients with suspected insulinoma who underwent 48-hour fasting test and GST were retrospectively included in our study: 15 patients with surgically proven insulinomas and 20 patients in whom insulinoma was clinically ruled out. (ovid.com)
  • citation needed] The insulinoma might be localized by noninvasive means, using ultrasound, CT scan, or MRI techniques. (wikipedia.org)
  • Adrenomedullin, a new peptide, in patients with insulinoma. (sigmaaldrich.com)
  • Diabetes Associated Peptide or Insulinoma Amyloid Peptide or IAPP pipeline Target constitutes close to 14 molecules. (bioportfolio.com)
  • The latest report Islet Amyloid Polypeptide Pipeline Review, H2 2017, outlays comprehensive information on the Islet Amyloid Polypeptide Amylin or Diabetes Associated Peptide or Insulinoma Amyloid Peptide or IAPP targeted therapeutics, complete with analysis by indications, stage of development, mechanism of action MoA, route of administration RoA and molecule type. (bioportfolio.com)
  • Islet Amyloid Polypeptide Amylin or Diabetes Associated Peptide or Insulinoma Amyloid Peptide or IAPP Islet amyloid polypeptide IAPP or Amylin is a peptide hormone. (bioportfolio.com)
  • Furthermore, this report also reviews key players involved in Islet Amyloid Polypeptide Amylin or Diabetes Associated Peptide or Insulinoma Amyloid Peptide or IAPP targeted therapeutics development with respective active and dormant or discontinued projects. (bioportfolio.com)
  • Global Markets Direct's, 'Islet Amyloid Polypeptide (Amylin or Diabetes Associated Peptide or Insulinoma Amyloid Peptide or IAPP) - Pipeline Review, H2 2016', provides in depth analysis on Islet Amyloid Polypeptide (Amylin or Diabetes Associated Peptide or Insulinoma Amyloid Peptide or IAPP) targeted pipeline therapeutics. (globalmarketsdirect.com)
  • Additionally, the report provides an overview of key players involved in Islet Amyloid Polypeptide (Amylin or Diabetes Associated Peptide or Insulinoma Amyloid Peptide or IAPP) targeted therapeutics development and features dormant and discontinued projects. (globalmarketsdirect.com)
  • Conduct a C-peptide test if a patient is suspected of self-administering insulin or oral hypoglycemics to mimic symptoms of insulinoma. (5minuteconsult.com)
  • PET tracers such as F-FDOPA and glucagon-like peptide 1 receptor analogs have been used for imaging insulinomas. (rare-cancer.org)
  • El insulinoma es la neoplasia m s frecuente entre los tumores neuroendocrinos del p ncreas. (medigraphic.com)
  • Because NO and its derivatives have been implicated as critical mediators of beta-cell destruction in IDDM, we conclude that well regulated insulinoma cell lines engineered for MnSOD overexpression may be an attractive alternative to isolated islets as vehicles for insulin replacement in autoimmune diabetes. (jci.org)
  • Surgery is the usual treatment for insulinoma. (medlineplus.gov)
  • LONDON--( BUSINESS WIRE )-- Technavio analysts forecast the global insulinoma treatment market to grow at a CAGR of over 3% during the forecast period, according to their latest market research report. (biospace.com)
  • Technavio has published a new market research report on the global insulinoma treatment market from 2019-2023. (biospace.com)
  • Strategic alliances are one of the major trends being witnessed in the global insulinoma treatment market 2019-2023 . (biospace.com)
  • Surgical advances play a major role in the growth of the global insulinoma treatment market as surgery is used as the first-line therapy for treatment. (biospace.com)
  • The global insulinoma treatment market research report provides market segmentation by type (surgery, drugs, and other treatments) and by region (the Americas, EMEA, and APAC). (biospace.com)
  • The surgery segment held the largest insulinoma treatment market share in 2018, accounting for over 64% of the market. (biospace.com)
  • Diazoxide treatment for insulinoma: a national UK survey. (bmj.com)
  • Surgical treatment of insulinomas. (medigraphic.com)
  • Kaplan EL, Lee CH. Recent advances in the diagnosis and treatment of insulinomas. (medigraphic.com)
  • Pitfalls in the surgical treatment of insulinoma. (medigraphic.com)
  • 2014) A systematic review of localization, surgical treatment options, and outcome of insulinoma. (springermedizin.de)
  • We present the case of an year-old woman with a symptomatic insulinoma who refused surgery and was treated with arterial embolization using trisacryl gelatin microspheres as definitive treatment. (deathtoall.info)
  • 90%) of insulinomas are nonmetastatic at presentation and can be surgically cured. (nih.gov)
  • The study was performed in nine patients with surgically treated insulinoma. (sigmaaldrich.com)
  • In July 2015 I was diagnosed with 2 insulinomas - both removed surgically at DUMC in NC. (mayoclinic.org)
  • If a single large or deep adenoma is within the pancreatic body or tail, if there are multiple lesions of the body or tail (or both), or if no insulinoma is found (an unusual circumstance), a distal, subtotal pancreatectomy is done. (msdmanuals.com)