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Insulin AntibodiesBiphasic InsulinsBromouracilInsulinChlorpropamidePhenforminInsulin, IsophaneAntibodiesInsulin AspartHypoglycemiaReceptor, InsulinComplement Activating EnzymesDiabetes Mellitus, Type 1Antibody SpecificityAntigen-Antibody ComplexAntibodies, ViralDiabetes MellitusAntibodies, BacterialAntibodies, MonoclonalRadioimmunoassayInsulin ResistanceAntibody FormationAntibodies, NeutralizingAntibody AffinityInsulin Receptor Substrate ProteinsProinsulinC-PeptideMolecular Sequence DataCetirizineLoveHistamine H1 Antagonists, Non-SedatingSister Mary Joseph's NoduleUmbilicusHistamine H1 AntagonistsBlood GlucoseNesidioblastosisLuminescent MeasurementsImmunoassayLuminescencePeriodicals as TopicMagneticsMagnetsGraves OphthalmopathyGraves DiseaseReceptor, IGF Type 1DiplopiaInsulin-Like Growth Factor IExophthalmosInsulin AntagonistsAutoantibodiesChromatography, AffinityRecombinant ProteinsAmino Acid SequenceChromatography, High Pressure LiquidChromatography, GelKinetics
Insulin Antibodies: Antibodies specific to INSULIN.Biphasic Insulins: An insulin preparation that is designed to provide immediate and long term glycemic control in a single dosage. Biphasic insulin typically contains a mixture of REGULAR INSULIN or SHORT-ACTING INSULIN combined with a LONG-ACTING INSULIN.Bromouracil: 5-Bromo-2,4(1H,3H)-pyrimidinedione. Brominated derivative of uracil that acts as an antimetabolite, substituting for thymine in DNA. It is used mainly as an experimental mutagen, but its deoxyriboside (BROMODEOXYURIDINE) is used to treat neoplasms.Insulin: A 51-amino acid pancreatic hormone that plays a major role in the regulation of glucose metabolism, directly by suppressing endogenous glucose production (GLYCOGENOLYSIS; GLUCONEOGENESIS) and indirectly by suppressing GLUCAGON secretion and LIPOLYSIS. Native insulin is a globular protein comprised of a zinc-coordinated hexamer. Each insulin monomer containing two chains, A (21 residues) and B (30 residues), linked by two disulfide bonds. Insulin is used as a drug to control insulin-dependent diabetes mellitus (DIABETES MELLITUS, TYPE 1).Chlorpropamide: A sulfonylurea hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. (From Martindale, The Extra Pharmacopoeia, 30th ed, p277)Phenformin: A biguanide hypoglycemic agent with actions and uses similar to those of METFORMIN. Although it is generally considered to be associated with an unacceptably high incidence of lactic acidosis, often fatal, it is still available in some countries. (From Martindale, The Extra Pharmacopoeia, 30th ed, p290)Insulin, Isophane: An intermediate-acting INSULIN preparation with onset time of 2 hours and duration of 24 hours. It is produced by crystallizing ZINC-insulin-PROTAMINES at neutral pH 7. Thus it is called neutral protamine Hagedorn for inventor Hans Christian Hagedorn.Antibodies: Immunoglobulin molecules having a specific amino acid sequence by virtue of which they interact only with the ANTIGEN (or a very similar shape) that induced their synthesis in cells of the lymphoid series (especially PLASMA CELLS).Insulin Aspart: Insulin that has been modified to contain an ASPARTIC ACID instead of a PROLINE at position 38 of the B-chain.Hypoglycemia: A syndrome of abnormally low BLOOD GLUCOSE level. Clinical hypoglycemia has diverse etiologies. Severe hypoglycemia eventually lead to glucose deprivation of the CENTRAL NERVOUS SYSTEM resulting in HUNGER; SWEATING; PARESTHESIA; impaired mental function; SEIZURES; COMA; and even DEATH.Receptor, Insulin: A cell surface receptor for INSULIN. It comprises a tetramer of two alpha and two beta subunits which are derived from cleavage of a single precursor protein. The receptor contains an intrinsic TYROSINE KINASE domain that is located within the beta subunit. Activation of the receptor by INSULIN results in numerous metabolic changes including increased uptake of GLUCOSE into the liver, muscle, and ADIPOSE TISSUE.Complement Activating Enzymes: Enzymes that activate one or more COMPLEMENT PROTEINS in the complement system leading to the formation of the COMPLEMENT MEMBRANE ATTACK COMPLEX, an important response in host defense. They are enzymes in the various COMPLEMENT ACTIVATION pathways.Diabetes Mellitus, Type 1: A subtype of DIABETES MELLITUS that is characterized by INSULIN deficiency. It is manifested by the sudden onset of severe HYPERGLYCEMIA, rapid progression to DIABETIC KETOACIDOSIS, and DEATH unless treated with insulin. The disease may occur at any age, but is most common in childhood or adolescence.Antibody Specificity: The property of antibodies which enables them to react with some ANTIGENIC DETERMINANTS and not with others. Specificity is dependent on chemical composition, physical forces, and molecular structure at the binding site.Antigen-Antibody Complex: The complex formed by the binding of antigen and antibody molecules. The deposition of large antigen-antibody complexes leading to tissue damage causes IMMUNE COMPLEX DISEASES.Antibodies, Viral: Immunoglobulins produced in response to VIRAL ANTIGENS.Diabetes Mellitus: A heterogeneous group of disorders characterized by HYPERGLYCEMIA and GLUCOSE INTOLERANCE.Antibodies, Bacterial: Immunoglobulins produced in a response to BACTERIAL ANTIGENS.Antibodies, Monoclonal: Antibodies produced by a single clone of cells.Radioimmunoassay: Classic quantitative assay for detection of antigen-antibody reactions using a radioactively labeled substance (radioligand) either directly or indirectly to measure the binding of the unlabeled substance to a specific antibody or other receptor system. Non-immunogenic substances (e.g., haptens) can be measured if coupled to larger carrier proteins (e.g., bovine gamma-globulin or human serum albumin) capable of inducing antibody formation.Insulin Resistance: Diminished effectiveness of INSULIN in lowering blood sugar levels: requiring the use of 200 units or more of insulin per day to prevent HYPERGLYCEMIA or KETOSIS.Antibody Formation: The production of ANTIBODIES by proliferating and differentiated B-LYMPHOCYTES under stimulation by ANTIGENS.Antibodies, Neutralizing: Antibodies that reduce or abolish some biological activity of a soluble antigen or infectious agent, usually a virus.Antibody Affinity: A measure of the binding strength between antibody and a simple hapten or antigen determinant. It depends on the closeness of stereochemical fit between antibody combining sites and antigen determinants, on the size of the area of contact between them, and on the distribution of charged and hydrophobic groups. It includes the concept of "avidity," which refers to the strength of the antigen-antibody bond after formation of reversible complexes.Insulin Receptor Substrate Proteins: A structurally-related group of signaling proteins that are phosphorylated by the INSULIN RECEPTOR PROTEIN-TYROSINE KINASE. The proteins share in common an N-terminal PHOSPHOLIPID-binding domain, a phosphotyrosine-binding domain that interacts with the phosphorylated INSULIN RECEPTOR, and a C-terminal TYROSINE-rich domain. Upon tyrosine phosphorylation insulin receptor substrate proteins interact with specific SH2 DOMAIN-containing proteins that are involved in insulin receptor signaling.Proinsulin: A pancreatic polypeptide of about 110 amino acids, depending on the species, that is the precursor of insulin. Proinsulin, produced by the PANCREATIC BETA CELLS, is comprised sequentially of the N-terminal B-chain, the proteolytically removable connecting C-peptide, and the C-terminal A-chain. It also contains three disulfide bonds, two between A-chain and B-chain. After cleavage at two locations, insulin and C-peptide are the secreted products. Intact proinsulin with low bioactivity also is secreted in small amounts.C-Peptide: The middle segment of proinsulin that is between the N-terminal B-chain and the C-terminal A-chain. It is a pancreatic peptide of about 31 residues, depending on the species. Upon proteolytic cleavage of proinsulin, equimolar INSULIN and C-peptide are released. C-peptide immunoassay has been used to assess pancreatic beta cell function in diabetic patients with circulating insulin antibodies or exogenous insulin. Half-life of C-peptide is 30 min, almost 8 times that of insulin.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Cetirizine: A potent second-generation histamine H1 antagonist that is effective in the treatment of allergic rhinitis, chronic urticaria, and pollen-induced asthma. Unlike many traditional antihistamines, it does not cause drowsiness or anticholinergic side effects.Love: Affection; in psychiatry commonly refers to pleasure, particularly as it applies to gratifying experiences between individuals.Histamine H1 Antagonists, Non-Sedating: A class of non-sedating drugs that bind to but do not activate histamine receptors (DRUG INVERSE AGONISM), thereby blocking the actions of histamine or histamine agonists. These antihistamines represent a heterogenous group of compounds with differing chemical structures, adverse effects, distribution, and metabolism. Compared to the early (first generation) antihistamines, these non-sedating antihistamines have greater receptor specificity, lower penetration of BLOOD-BRAIN BARRIER, and are less likely to cause drowsiness or psychomotor impairment.Sister Mary Joseph's Nodule: Metastatic lesion of the UMBILICUS associated with intra-abdominal neoplasms especially of the GASTROINTESTINAL TRACT or OVARY.Umbilicus: The pit in the center of the ABDOMINAL WALL marking the point where the UMBILICAL CORD entered in the FETUS.Histamine H1 Antagonists: Drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine. Included here are the classical antihistaminics that antagonize or prevent the action of histamine mainly in immediate hypersensitivity. They act in the bronchi, capillaries, and some other smooth muscles, and are used to prevent or allay motion sickness, seasonal rhinitis, and allergic dermatitis and to induce somnolence. The effects of blocking central nervous system H1 receptors are not as well understood.Blood Glucose: Glucose in blood.Nesidioblastosis: An inherited autosomal recessive syndrome characterized by the disorganized formation of new islets in the PANCREAS and CONGENITAL HYPERINSULINISM. It is due to focal hyperplasia of pancreatic ISLET CELLS budding off from the ductal structures and forming new islets of Langerhans. Mutations in the islet cells involve the potassium channel gene KCNJ11 or the ATP-binding cassette transporter gene ABCC8, both on CHROMOSOME 11.Luminescent Measurements: Techniques used for determining the values of photometric parameters of light resulting from LUMINESCENCE.Immunoassay: A technique using antibodies for identifying or quantifying a substance. Usually the substance being studied serves as antigen both in antibody production and in measurement of antibody by the test substance.Luminescence: Emission of LIGHT when ELECTRONS return to the electronic ground state from an excited state and lose the energy as PHOTONS. It is sometimes called cool light in contrast to INCANDESCENCE. LUMINESCENT MEASUREMENTS take advantage of this type of light emitted from LUMINESCENT AGENTS.Periodicals as Topic: A publication issued at stated, more or less regular, intervals.Magnetics: The study of MAGNETIC PHENOMENA.Magnets: Objects that produce a magnetic field.Graves Ophthalmopathy: An autoimmune disorder of the EYE, occurring in patients with Graves disease. Subtypes include congestive (inflammation of the orbital connective tissue), myopathic (swelling and dysfunction of the extraocular muscles), and mixed congestive-myopathic ophthalmopathy.Graves Disease: A common form of hyperthyroidism with a diffuse hyperplastic GOITER. It is an autoimmune disorder that produces antibodies against the THYROID STIMULATING HORMONE RECEPTOR. These autoantibodies activate the TSH receptor, thereby stimulating the THYROID GLAND and hypersecretion of THYROID HORMONES. These autoantibodies can also affect the eyes (GRAVES OPHTHALMOPATHY) and the skin (Graves dermopathy).Receptor, IGF Type 1: A protein-tyrosine kinase receptor that is closely related in structure to the INSULIN RECEPTOR. Although commonly referred to as the IGF-I receptor, it binds both IGF-I and IGF-II with high affinity. It is comprised of a tetramer of two alpha and two beta subunits which are derived from cleavage of a single precursor protein. The beta subunit contains an intrinsic tyrosine kinase domain.Diplopia: A visual symptom in which a single object is perceived by the visual cortex as two objects rather than one. Disorders associated with this condition include REFRACTIVE ERRORS; STRABISMUS; OCULOMOTOR NERVE DISEASES; TROCHLEAR NERVE DISEASES; ABDUCENS NERVE DISEASES; and diseases of the BRAIN STEM and OCCIPITAL LOBE.Insulin-Like Growth Factor I: A well-characterized basic peptide believed to be secreted by the liver and to circulate in the blood. It has growth-regulating, insulin-like, and mitogenic activities. This growth factor has a major, but not absolute, dependence on GROWTH HORMONE. It is believed to be mainly active in adults in contrast to INSULIN-LIKE GROWTH FACTOR II, which is a major fetal growth factor.Exophthalmos: Abnormal protrusion of both eyes; may be caused by endocrine gland malfunction, malignancy, injury, or paralysis of the extrinsic muscles of the eye.Insulin Antagonists: Compounds which inhibit or antagonize the biosynthesis or action of insulin.Autoantibodies: Antibodies that react with self-antigens (AUTOANTIGENS) of the organism that produced them.Chromatography, Affinity: A chromatographic technique that utilizes the ability of biological molecules to bind to certain ligands specifically and reversibly. It is used in protein biochemistry. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Recombinant Proteins: Proteins prepared by recombinant DNA technology.Amino Acid Sequence: The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.Chromatography, High Pressure Liquid: Liquid chromatographic techniques which feature high inlet pressures, high sensitivity, and high speed.Chromatography, Gel: Chromatography on non-ionic gels without regard to the mechanism of solute discrimination.Kinetics: The rate dynamics in chemical or physical systems.

Frequency of islet cell autoantibodies (IA-2 and GAD) in young Brazilian type 1 diabetes patients. (1/202)

Type 1 diabetes, as an autoimmune disease, presents several islet cell-specific autoantibodies such as islet cell antibody (ICA), anti-insulin, anti-glutamic acid decarboxylase (GAD) and the antibody (Ab) against tyrosine phosphatase (PTP)-like protein known as ICA-512 (IA-2). In order to determine the frequency of the anti-GAD and anti-IA-2 autoantibodies in Brazilian type 1 diabetes patients we studied 35 diabetes mellitus (DM) type 1 patients with recent-onset disease (12 months) who were compared to 12 children with normal fasting glucose. Anti-GAD65 and anti-IA-2 autoantibodies were detected with commercial immunoprecipitation assays. The frequency of positive results in recent-onset DM type 1 patients was 80.0% for GADAb, 62.9% for IA-2Ab and 82.9% for GADAb and/or IA-2Ab. The long-duration type 1 diabetes subjects presented frequencies of 54.1% for GADAb and IA-2Ab, and 67.5% for GAD and/or IA-2 antibodies. The control group showed no positive cases. Anti-GAD and IA-2 assays showed a high frequency of positivity in these Brazilian type 1 diabetes patients, who presented the same prevalence as a Caucasian population.  (+info)

Lack of association between early childhood immunizations and beta-cell autoimmunity. (2/202)

OBJECTIVE: To determine whether early childhood immunization history affects the risk of developing the beta-cell autoimmunity that precedes type 1 diabetes. RESEARCH DESIGN AND METHODS: This article describes a case-control study whose participants were 317 children aged < or = 12 years who have a first-degree relative with type 1 diabetes. The children were enrolled in a prospective cohort study of the etiology of beta-cell autoimmunity, the Diabetes Autoimmunity Study in the Young, in Denver, Colorado. The main outcome measure was beta-cell autoimmunity as determined by persistent autoantibodies against insulin, GAD, or islet cell antibody (IA-2) 512. The number of cases with beta-cell autoimmunity was 25, and the number of control subjects (the remainder of the cohort) was 292. RESULTS: There was no difference between cases and control subjects in the proportion receiving hepatitis B (HBV), Haemophilus influenzae b (Hib), polio, or diphtheria tetanus pertussis (DTP) vaccines before 9 months of age; in the proportion receiving HBV at birth rather than later; or in the median age at first HBV, Hib, polio, or DTP vaccination. CONCLUSIONS: The results suggest that changing the early childhood immunization schedule would not affect the risk of developing beta-cell autoimmunity or type 1 diabetes.  (+info)

Effect of Bacillus Calmette-Guerin vaccination on new-onset type 1 diabetes. A randomized clinical study. (3/202)

OBJECTIVE: We undertook this study to test whether Bacillus Calmette-Guerin (BCG) vaccine preserves beta-cell function and increases the remission rate in children with new-onset type 1 diabetes. RESEARCH DESIGN AND METHODS: This was a randomized double-blind placebo-controlled trial offered to children referred to the Barbara Davis Center for Childhood Diabetes or the Baystate Medical Center with a diagnosis of new-onset type 1 diabetes. There were 94 children aged 5-18 years who received either BCG or saline intradermally within 4 months of onset of symptoms and who were then evaluated at 3-month intervals for 2 years. The primary end point was remission, defined as insulin independence for 4 weeks. Secondary end points were C-peptide levels (fasting and in response to a mixed meal challenge), insulin dose, and HbA1c. RESULTS: Of the patients, 47 were randomized to each arm; 7 in the placebo group and 9 in the BCG group did not complete 1 year of the study and are not included in the analysis. One patient from each group achieved remission. Fasting and stimulated C-peptide levels did not differ by treatment arm but declined in both groups and were lower initially and during the entire 2-year period in younger children. Insulin requirements and HbA1c levels did not differ in the two groups. CONCLUSIONS: Vaccination with BCG at the time of onset of type 1 diabetes does not increase the remission rate or preserve beta-cell function.  (+info)

Early expression of antiinsulin autoantibodies of humans and the NOD mouse: evidence for early determination of subsequent diabetes. (4/202)

With the development of an insulin autoantibody (IAA) assay performed in 96-well filtration plates, we have evaluated prospectively the development of IAA in NOD mice (from 4 weeks of age) and children (from 7 to 10 months of age) at genetic risk for the development of type 1 diabetes. NOD mice had heterogeneous expression of IAA despite being inbred. IAA reached a peak between 8 and 16 weeks and then declined. IAA expression by NOD mice at 8 weeks of age was strongly associated with early development of diabetes, which occurred at 16-18 weeks of age (NOD mice IAA(+) at 8 weeks: 83% (5/6) diabetic by 18 weeks versus 11% (1/9) of IAA negative at 8 weeks; P <.01). In man, IAA was frequently present as early as 9 months of age, the first sampling time. Of five children found to have persistent IAA before 1 year of age, four have progressed to diabetes (all before 3.5 years of age) and the fifth is currently less than age 2. Of the 929 children not expressing persistent IAA before age 1, only one has progressed to diabetes to date (age onset 3), and this child expressed IAA at his second visit (age 1.1). In new onset patients, the highest levels of IAA correlated with an earlier age of diabetes onset. Our data suggest that the program for developing diabetes of NOD mice and humans is relatively "fixed" early in life and, for NOD mice, a high risk of early development of diabetes is often determined by 8 weeks of age. With such early determination of high risk of progression to diabetes, immunologic therapies in humans may need to be tested in children before the development of IAA for maximal efficacy.  (+info)

Antibody-mediated insulin resistance treated by cessation of insulin administration. (5/202)

A 45-year-old Japanese man was referred to our hospital because of hyperglycemia despite the administration of as much as 120 U/day of human insulin. He had no history of injecting animal insulin. Free insulin was below 5 microU/ml, but a high titer of total insulin (about 3,000 microU/ml) was observed, suggesting the presence of antibodies against human insulin. Scatchard analysis showed an increased insulin binding capacity in the plasma characterized by a higher affinity for insulin. He was successfully treated by cessation of insulin administration. A Scatchard analysis series showed that a reduction in the insulin binding capacity of antibodies paralleled the improvement in glycemic control.  (+info)

Association between rotavirus infection and pancreatic islet autoimmunity in children at risk of developing type 1 diabetes. (6/202)

Pancreatic islet autoimmunity leading to type 1 diabetes could be triggered by viruses in genetically susceptible individuals. Rotavirus (RV), the most common cause of childhood gastroenteritis, contains peptide sequences highly similar to T-cell epitopes in the islet autoantigens GAD and tyrosine phosphatase IA-2 (IA-2), suggesting T-cells to RV could trigger islet autoimmunity by molecular mimicry. We therefore sought an association between RV infection and islet autoantibody markers in children at risk for diabetes who were followed from birth. There was a specific and highly significant association between RV seroconversion and increases in any of these antibodies: 86% of antibodies to IA-2, 62% to insulin, and 50% to GAD first appeared or increased with increases in RV IgG or IgA. RV infection may therefore trigger or exacerbate islet autoimmunity in genetically susceptible children.  (+info)

Immunoreactive somatostatin is present in discrete cells of the endocrine pancreas. (7/202)

A discrete population of cells of the endocrine pancreas contains immunoreactive somatostatin as shown by immunofluorescence. These cells are different from those containing glucagon or insulin. This unexpected observation may be of physiopathological significance in the regulatory mechanisms involved in the secretion of glucagon and insulin.  (+info)

Use of an islet cell antibody assay to identify type 1 diabetic patients with rapid decrease in C-peptide levels after clinical onset. Belgian Diabetes Registry. (8/202)

OBJECTIVE: To investigate whether the presence of antibody markers at diagnosis could help predict the rapid decrease in residual beta-cell function noted in some, but not all, patients with recent-onset type 1 diabetes. RESEARCH DESIGN AND METHODS: We measured random C-peptide levels (radioimmunoassay); islet cell cytoplasmic antibodies (ICA) (indirect immunofluorescence); and antibodies against IA-2 protein, 65-kDa glutamate decarboxylase, and insulin (liquid-phase radiobinding assays) in 172 patients <40 years of age with type 1 diabetes. The patients had been consecutively recruited at diagnosis by the Belgian Diabetes Registry and were followed for 2 years. RESULTS: Two years after diagnosis, random C-peptide levels had decreased significantly (P < 0.001) in ICA+ patients but not in ICA- patients. C-peptide values <50 pmol/ were noted in 88% of patients diagnosed before 7 years of age, in 45% of patients diagnosed between ages 7 and 15 years, and in 29% of patients diagnosed after 15 years of age (P < 0.001). In cases of clinical onset before age 15 years, a rapid decline in random C-peptide values was observed almost exclusively in patients with high-titer ICA (> or =50 Juvenile Diabetes Foundation [JDF] units) at diagnosis (69 vs. 17% in patients with lower ICA titers, P < 0.001). In patients diagnosed after 15 years of age, 36% of patients with ICA titers > or =12JDF units developed low C-peptide levels compared with 14% of patients with ICA titers < 12 JDF units (P < 0.03). Multivariate analysis confirmed that C-peptide levels after 2 years were inversely correlated with ICA levels (P < 0.001) and to a lesser degree positively correlated with age at diagnosis (P < 0.02), regardless of the levels or number of molecular autoantibodies. CONCLUSIONS: Young age at diagnosis and high-titer ICA identify a group of type 1 diabetic patients at high risk of rapidly losing residual beta-cell function. Using these selection criteria, it is possible to better target beta-cell-preserving interventions to patients with or without such rapid progression, depending on the nature of the tested substance. The ICA assay measures clinically relevant antibodies not detected in antibody assays that use recombinant human autoantigens for substrate.  (+info)

Insulin Antibodies | Private Blood TestsInsulin Antibodies | Private Blood Tests
This private blood analysis for Insulin Antibodies is accessible at all thirty one private clinics around the UK Included in each order for Insulin Antibodies are a Doctors Referral, all Phlebotomy fees (your blood taken at a Private Hospital), all laboratory fees and includes our GP comments.
Isotypic and idiotypic analysis of murine anti-insulin antibodies. Ab by P F. Robbins and J A. Kapp"Isotypic and idiotypic analysis of murine anti-insulin antibodies. Ab" by P F. Robbins and J A. Kapp
Robbins, P F. and Kapp, J A., "Isotypic and idiotypic analysis of murine anti-insulin antibodies. Abstr." (1980). Subject Strain Bibliography 1980. 2257 ...
anti-Insulin antibody | GeneTexanti-Insulin antibody | GeneTex
Insulin antibody (insulin) for ICC/IF, IHC-Fr, IHC-P. Anti-Insulin pAb (GTX27842) is tested in Human, Mouse samples. 100% Ab-Assurance.
Anti-Rat (Rattus) Insulin antibody for Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))Anti-Rat (Rattus) Insulin antibody for Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))
Compare & find the top performing anti-Rat (Rattus) Insulin antibody for Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp)).
Anti-Insulin antibody (ab53591) | AbcamAnti-Insulin antibody (ab53591) | Abcam
Rabbit polyclonal Insulin antibody. Validated in ELISA, RIA and tested in Human. Cited in 1 publication(s). Immunogen corresponding to recombinant full length protein.
Insulin Antibody (E2-E3 (same as INS04)) [PerCP] (NBP2-34611PCP): Novus BiologicalsInsulin Antibody (E2-E3 (same as INS04)) [PerCP] (NBP2-34611PCP): Novus Biologicals
Mouse Monoclonal Anti-Insulin Antibody (E2-E3 (same as INS04)) [PerCP]. beta-Cell & Insulinoma Marker. Validated: WB. Tested Reactivity: Human, Mouse, Porcine, and more. 100% Guaranteed.
Insulin autoimmune syndrome: case reportInsulin autoimmune syndrome: case report
During the preoperative period, verapamil and prednisone were prescribed without success. After five months in hospital, no signs of remission of hypoglycemia were detected. Surgery was indicated due to the severity of the episodes and because immunosuppressants were contraindicated due to bacteremia. During the operation, no tumor was found by palpation, thus prompting the decision to perform subtotal pancreatectomy. Histological examination demonstrated diffuse hyperplasia of beta cells. Data on antibody levels were available only after the surgical procedure. The levels of islet cell antibody (ICA) and glutamic acid decarboxylase antibody (anti-GAD) were within normal range. Insulin auto-antibodies (IAA) were elevated (107.30 IU/ml; the reference range is from 0.00 to 1.00). Insulin autoimmune syndrome was thus identified as the cause of the hypoglycemia. The patient has continued to have hypoglycemic episodes, albeit less frequent and less severe. His insulin (2479 mIU/ml) and C peptide (4.9 ...
Anti-Insulin Antibodies - Process-Related Impurity Antibodies - Antibodies - ProductsAnti-Insulin Antibodies - Process-Related Impurity Antibodies - Antibodies - Products
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Aerosol Insulin Induces Regulatory CD8 γδ T Cells That Prevent Murine Insulin-dependent Diabetes | Journal of Experimental...Aerosol Insulin Induces Regulatory CD8 γδ T Cells That Prevent Murine Insulin-dependent Diabetes | Journal of Experimental...
Insulin antibodies were measured by a standard immunoprecipitation assay with sera (n = 12 per group) from insulin- and OVA-treated mice aged 70-105 d. Precipitation of 125I-insulin radioactivity by antibodies in sera from insulin-treated mice (12.7 ± 3.6%; mean precipitated cpm ± SD) was significantly higher (P ,0.01, Mann-Whitney U test) than in OVA-treated mice (6.9 ± 2.6%). This increase in the "level" of insulin antibodies after aerosol insulin, together with the suppression of T cell proliferation and the increase in IL-4 and IL-10 responses to the insulin B chain peptide, is consistent with the phenomenon of immune deviation, as described after oral myelin basic protein in Lewis rats (16) and intranasal GAD peptides in NOD mice (22). β cell destruction within the DTH lesion of IDDM is an example of a Th1-mediated process (1, 2), whose inhibition by aerosol insulin might be expected to shift the Th1/ Th2 balance towards Th2 in response to key islet antigens. Defective suppressor T cell ...
Insulin Antibodies, Serum - Meriter LaboratoriesInsulin Antibodies, Serum - Meriter Laboratories
Predicting the future development of type 1 diabetes in asymptomatic children, adolescents, and young adults, when used in conjunction with family history, HLA-typing, and other autoantibodies, including GD65S/81596 Glutamic Acid Decarboxylase (GAD65) Antibody Assay, Serum and islet cell antigen 2 (IA-2) antibodies. Differential diagnosis of type 1 versus type 2 diabetes. Evaluating diabetics with insulin resistance in patients with established diabetes (type 1 or type 2). Investigation of hypoglycemia in nondiabetic subjects. ...
Insulin Antibodies, Serum - Barnes-Jewish HospitalInsulin Antibodies, Serum - Barnes-Jewish Hospital
Predicting the future development of type 1 diabetes in asymptomatic children, adolescents, and young adults, when used in conjunction with family history, HLA-typing, and other autoantibodies, including GD65S/81596 Glutamic Acid Decarboxylase (GAD65) Antibody Assay, Serum and islet cell antigen 2 (IA-2) antibodies. Differential diagnosis of type 1 versus type 2 diabetes. Evaluating diabetics with insulin resistance in patients with established diabetes (type 1 or type 2). Investigation of hypoglycemia in nondiabetic subjects. ...
RE: [IPk] Insulin antibodies and tape allergyRE: [IPk] Insulin antibodies and tape allergy
Mary, Youve probably tried everything Im going to say, but you never know...so I hope you wont think Im being condesending. No way, Mary. Thanks for all that. Sadly Quicksets dont seem to work for me. At least they didnt before. I may still have one or two so could try them again. Last night I gave up after 36 hours and changed set again! Sorry NHS for using all these resources! I used a SofSet with the extra film underneath it. 12 hours on and no rash! Yes, please, Id love to try a few Kendall Polyskin 2. Ill send you my details off-list. I have 1% hydrocortisone cream as standby but the doc is not keen on me using it as I seem to develop rashes/allergic rashes so readily. You should also use clean skin which looks and feels normal beforehand. [RCM] Ive tried that but somehow my skin seems to fool me ,g, It also might be worth changing your antihistamines now and then. [RCM] Good point. Ive been on my current one for a couple of years. (Cetirizine) (I am allergic to cat fur but I ...
Insulin AntibodiesInsulin Antibodies
Note: Reference ranges provided on this web site are for guidance only, and may not reflect the most recent changes. Refer to laboratory reports for current reference data. UNC ...
Insulin Detection: AntibodiesInsulin Detection: Antibodies
Human insulin monoclonal antibody may be used for the analysis of the structure, function, and metabolism of insulin. This anti-insulin antibody, also known as INS antibody, is applicable for Western blot (WB) analysis under non-reducing and non-heating conditions and for immunohistological (IHC) studies of frozen tissue sections.. Antibodies to the proinsulin C-peptide (also known as insulin C) are frequently used to study the structure, function, and metabolism of insulin as well as proinsulin. Insulin C antibodies can also be used for immunocytochemistry (ICC) and for immunohistochemical (IHC) studies of paraffin-embedded or frozen tissue sections. The following insulin C antibodies are available:. ...
Insulin Detection: AntibodiesInsulin Detection: Antibodies
Human insulin monoclonal antibody may be used for the analysis of the structure, function, and metabolism of insulin. This anti-insulin antibody, also known as INS antibody, is applicable for Western blot (WB) analysis under non-reducing and non-heating conditions and for immunohistological (IHC) studies of frozen tissue sections.. Antibodies to the proinsulin C-peptide (also known as insulin C) are frequently used to study the structure, function, and metabolism of insulin as well as proinsulin. Insulin C antibodies can also be used for immunocytochemistry (ICC) and for immunohistochemical (IHC) studies of paraffin-embedded or frozen tissue sections. The following insulin C antibodies are available:. ...
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Total immunoreactive insulin (IRI) is conventionally determined by radioimmunoassays. IRI measurement in rats can be made more sensitive, accurate, and practical, as demonstrated by a new modified enzyme-linked immunosorbent assay (ELISA). It is characterized by indirect binding of an anti-insulin antibody by an antiglobulin antibody and uses the principle of competitive saturation. In this ELISA, IRI can be determined in a wide range of concentrations, corresponding to the standards. The standard curve ranges from 100 to 0.049 ng/ml IRI (1 ng/ml ∼ 23.4 μU/ml ∼ 172 pM rat insulin). The statistical analysis shows between- and within-assay coefficients of variation of ≤ 15%.. ...
Needle Free Insulin Devices Market 2017-2024 is predicatedNeedle Free Insulin Devices Market 2017-2024 is predicated
Press release - Kenneth Research - Needle Free Insulin Devices Market 2017-2024 is predicated to experience a massive growth during the forecast period - published on openPR.com
Anti-Insulin Affibody® Molecule (ab31906) | AbcamAnti-Insulin Affibody® Molecule (ab31906) | Abcam
Anti-Insulin Affibody® Molecule Affibody® Molecule datasheet (ab31906). Abcam offers quality products including antibodies, assays and other reagents.
Anti-Insulin Like Growth Factor 2 (IGF2) Protein (Recombinant) abx167743 | GentaursearchAnti-Insulin Like Growth Factor 2 (IGF2) Protein (Recombinant) abx167743 | Gentaursearch
Anti-Insulin Like Growth Factor 2 (IGF2) Protein (Recombinant) datasheet and description hight quality product and Backed by our Guarantee
MRN Exonuclease - NF-κB signaling in inflammation and cancerMRN Exonuclease - NF-κB signaling in inflammation and cancer
Supplementary MaterialsSupplementary Information 41598_2017_16281_MOESM1_ESM. microscopic level, IPA-N3 treated seedlings also demonstrated swelled root suggestion appearance (Fig.?2d) and ectopic lateral main initiation while IAA (Fig.?2e,f). The morphogen activity of IPA-N3 may be proven by inducing body organ initiation for the take meristem from the mutant (Fig.?2g) defective in forming auxin maxima31,32. This demonstrates substitution with an […]. Read More ». ...
Total and Free Insulin (Blood)Total and Free Insulin (Blood)
This test measures two types of insulin in your body: total and free. The test can help diagnose low blood sugar, or hypoglycemia.
Insulin抗体[3A6]|Abcam中国|Anti-Insulin抗体[3A6]Insulin抗体[3A6]|Abcam中国|Anti-Insulin抗体[3A6]
Insulin小鼠单克隆抗体[3A6](ab1965)可与人, 猪样本反应并经ELISA, IHC, sELISA实验严格验证并得到1个独立的用户反馈。所有产品均提供质保服务，中国75%以上现货。
IP] kids today and yesterdayIP] kids today and yesterday
It is so encouraging to hear that Kids are doing SOOOO well with diabetes these days. Back in the dark ages my personal rule in staying alive between the ages 12-18 was to swim 45 minutes in the morning, 1/2 hour lifting free weights in the evening, swim 11/2 hr. evening. Bike EVERYWHERE. My coach was so dedicated to me (and my swimming) and my disease that he would hold a wrench over the end of my lane so I couldnt get out when exhausted. He was a biology teacher and knew what glucose was doing to my body. If I went low there was a quart of OJ near by. He told me if I didnt submitt to the pain, Id be blind and footless by age 20. Oh yeah, they wouldnt prescribe regular insulin to me until I was 17-- so I was on NPH Beef (only) for 5 years and extreme excercise was my only means of dealing with eating. My skin began to collapse because of a reaction to the beef insulin and they switched to pork. I have to say I had a pretty darn buff body too, and I won all the meets! But my fat count was so ...
Insulin R/CD220 Antibody (NBP1-47580): Novus BiologicalsInsulin R/CD220 Antibody (NBP1-47580): Novus Biologicals
Rabbit Polyclonal Anti-Insulin R/CD220 Antibody. Validated: WB, IHC, IHC-P. Tested Reactivity: Human, Mouse, Rat. 100% Guaranteed.
Infrastructure as a Service (IaaS) & Enterprise Cloud Architecture - InformationWeekInfrastructure as a Service (IaaS) & Enterprise Cloud Architecture - InformationWeek
InformationWeek helps you navigate the complex world of enterprise cloud architecture. Avoid IaaS bias and learn from your peers cloud computing projects.
Diabetes Antibody Standardization Program: evaluation of assays for insulin autoantibodies - University of BristolDiabetes Antibody Standardization Program: evaluation of assays for insulin autoantibodies - University of Bristol
TY - JOUR. T1 - Diabetes Antibody Standardization Program: evaluation of assays for insulin autoantibodies. AU - Schlosser, M. AU - Mueller, PW. AU - Törn, C. AU - Bonifacio, E. AU - Bingley, PJ. AU - Participating, Laboratories. PY - 2010/12. Y1 - 2010/12. N2 - AIMS/HYPOTHESIS: Insulin autoantibodies (IAA) are important in type 1 diabetes risk assessment. However, their determination varies more between laboratories than other diabetes autoantibodies. The Diabetes Antibody Standardization Program (DASP) aims to improve and standardise measurement of autoantibodies associated with type 1 diabetes. We report the results of measurement of IAA from DASP workshops in 2002, 2003 and 2005. METHODS: Up to 32 laboratories in 14 countries participated in each workshop. Aliquots of coded sera from 50 patients with newly diagnosed type 1 diabetes and 100 blood donor controls were circulated to participating laboratories. Reported results were analysed using receiver operator characteristic (ROC) curves. ...
Insulin autoantibodies are associated with islet inflammation but not always related to diabetes progression in NOD congenic...Insulin autoantibodies are associated with islet inflammation but not always related to diabetes progression in NOD congenic...
Susceptibility to diabetes in humans and nonobese diabetic (NOD) mice is believed to arise from the combined effect of multiple genetic loci, resulting in immune-mediated destruction of the insulin-secreting beta-cells. Insulin autoantibodies (IAAs) are often present in humans for years, and in NOD mice for weeks, before the onset of diabetes. We have evaluated the expression of IAAs in NOD mice and in diabetes-resistant NOD congenic strains to characterize the association of autoantibody expression with insulitis and diabetes. In NOD congenic strains with genes that contribute to protection from insulitis and diabetes (Idd3, Idd5, Idd10, and Idd18), the prevalence of IAAs is reduced relative to NOD mice. In contrast, NOD.B10 Idd9 mice have a high prevalence of IAAs and a high degree of insulitis, despite a nearly complete resistance to diabetes. These data indicate that IAA expression is a phenotype that is associated with insulitis and correlates with overall disease progression in some strains of
Insulin Autoantibodies: Evidence of Autoinmune Disease Among a Group of Puerto Rican Children with Newly Diagnosed Type 1...Insulin Autoantibodies: Evidence of Autoinmune Disease Among a Group of Puerto Rican Children with Newly Diagnosed Type 1...
Insulin Autoantibodies: Evidence of Autoinmune Disease Among a Group of Puerto Rican Children with Newly Diagnosed Type 1 Diabetes Mellitus
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Kim et al. (1) recently reported autoimmune hypoglycemia in a type 2 diabetic patient with anti-insulin and insulin receptor antibodies. The patient was a 72-year-old woman with suitable clinic and laboratory data for autoimmune hypoglycemia. Her plasma glucose was 40 mg/dl, insulin 103.7 μU/ml, and C-peptide 4.1 ng/ml. The authors state, "Patients with this condition have low circulation insulin, C-peptide levels, and refractory hypoglycemia." We believe that this sentence is discordant with the rest of the letter and patients given data.. Hypoglycemia owing to insulin antibodies is rare but should be considered in any patient with hypoglycemia in the setting of nonsuppressed insulin levels, i.e., insulin levels that are markedly elevated, usually ,100 μU/ml, as in the given patient (2). Free insulin levels may be normal or high, and C-peptide levels are not suppressed (3).. In hypoglycemia due to insulin receptor antibodies, insulin levels are usually higher than appropriate for the glucose ...
From Flatbush New York to London, via Paris: Ketosis-prone type 2 diabetes, a distinct form of diabetes were only beginning to...From Flatbush New York to London, via Paris: Ketosis-prone type 2 diabetes, a distinct form of diabetes we're only beginning to...
This Diabetes Week, its important to remember that there are more than just two types of diabetes and how global insights into ethnic-specific types can benefit local people with diabetes.. Most people have heard of the two main types of diabetes. Type 1 diabetes is caused by destruction of the beta-cells that make insulin in the pancreas. Without insulin injections, people with type 1 diabetes are at risk of a life-threatening complication called diabetic ketoacidosis, where the blood gradually becomes acidic due to the accumulation of ketones. Type 2 diabetes is different and is primarily related to insulin resistance; the beta-cells make insulin, but the body tissues dont respond to it appropriately. Type 2 diabetes can initially be managed with tablets.. In the past you could be pretty sure that if a person presented to hospital with diabetic ketoacidosis, this meant they had type 1 diabetes and needed lifelong insulin. We had all learnt this from textbooks at medical school - that the ...
1992 - Symptoms of hypoglycemia with human versus porcine insulin | 1992 Mar-Apr : Volume 116, Number 2, Page 33 | ACP Journal...1992 - Symptoms of hypoglycemia with human versus porcine insulin | 1992 Mar-Apr : Volume 116, Number 2, Page 33 | ACP Journal...
We have departed from our usual format of 1 page for the article by Egger and colleagues for several reasons. First, hypoglycemia unawareness among diabetic patients on insulin therapy is emerging as an important problem, but one that is difficult to study. Investigations such as that by Egger and his colleagues are contributing to better definition and measurement of symptoms of hypoglycemia, an important contribution in its own right. Second, this study, and the earlier one of Berger and colleagues (see above), provide evidence about human insulin that has some patients and physicians upset and manufacturers of human insulin on edge. Human insulin was introduced with randomized controlled trials showing equivalence in blood sugar lowering effects but no evidence of patient benefit in addition to that conferred by animal insulin (unless one believes that freedom from insulin antibodies is clinically important). Larger premarketing studies would have been required to determine whether there was ...
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In eleven insulin sensitive and in six insulin resistant diabetic patients, insulin-like activity was measured in unmodified serum and in the corresponding acid ethanol extract shown to be free of insulin antibodies. Whereas most of the insulin responsive and four insulin resistant diabetic patients exhibited a similar ratio of insulin-like activity of serum to the respective serum extract, two patients with insulin resistance exhibited a more than one-hundredfold increase in this ratio.. Of the factors analyzed, i.e., length of insulin treatment, daily insulin dose, maximum serum insulin binding capacity, serum ILA and serum extract ILA, only insulin binding capacity and serum extract ILA exhibited a positive correlation in both the insulin responsive and insulin resistant patients.. ...
Newborn screening for HLA markers associated with IDDM: diabetes autoimmunity study in the young (DAISY)Newborn screening for HLA markers associated with IDDM: diabetes autoimmunity study in the young (DAISY)
Autoimmunity causing insulin-dependent diabetes mellitus (IDDM) begins in early childhood due to interactions between genes and unknown environmental factors that may be identified through follow-up of a large cohort of genetically susceptible children. Such a cohort has been established using a sim …
Autoantibodies Associated with Diabetes - Articles on Medical Diseases and ConditionsAutoantibodies Associated with Diabetes - Articles on Medical Diseases and Conditions
About 60%-90% of type I (insulin-dependent) diabetics have antibody against islet cell cytoplasmic glycoprotein ("islet cell autoantibody") at the time of diagnosis, and many of those initially without this antibody develop it later. This antibody disappears within 2 years after appearance in 85%-90% of type I diabetics. It has also been reported in about 20% of type II diabetics and about 10% of gestational diabetics at time of diagnosis. About 30%-50% of children have autoantibody against insulin (antiinsulin antibody) at time of diagnosis before beginning insulin therapy and some (much less than formerly) develop it after using therapeutic insulin. Some patients have autoantibodies against beta cell surface antigen (beta cell antibodies). Over 95% of type I patients possess the human lymphocyte antigen (HLA) DR3 or DR4. However, at present these autoantibodies and HLAs are not being widely used in clinical medicine or in diagnosis.. ...
Zhao, T.Y., Li, F. and Xiong, Z.Y. (2010) Frequent Reoccurrence of Hypoglycemia in a Type 2 Diabetic Patient with Insulin...Zhao, T.Y., Li, F. and Xiong, Z.Y. (2010) Frequent Reoccurrence of Hypoglycemia in a Type 2 Diabetic Patient with Insulin...
Zhao, T.Y., Li, F. and Xiong, Z.Y. (2010) Frequent Reoccurrence of Hypoglycemia in a Type 2 Diabetic Patient with Insulin Antibodies. Molecular Diagnosis and Therapy, 14, 237-241.
Items where Subject is Tuberculosis | Laboratory Research | Immunological - EPrints@NIRTItems where Subject is "Tuberculosis | Laboratory Research | Immunological" - [email protected]
Sahadevan, R and Narayanan, S and Paramasivan, C N and Prabhakar, R and Narayanan, P R (1995) Restriction fgragment length polymorphism typing of clinical isolates of mycobacterium tuberculosis from patients with pulmonary tuberculosis in Madras, India, by use of direct-repeat probe. Journal of Clinical Microbiology, 33 (11). pp. 3037-3039. ISSN Print: 0095-1137; Online: 1098-660X Sanjeevi, C B and Narayanan, P R (1989) Antifilarial and Anti PPD IgM Antibodies in Cord Blood. Indian Journal of Pediatrics, 56 (2). pp. 207-211. ISSN Print: 0019-5456; Online: 0973-7693 Sanjeevi, C B and Narayanan, P R and Prabhakar, R and Charles, N and Thomas, B E and Balasubramanian, R and Olerup, O (1992) No association or linkage with HLA-DR or -DQ and genes in South India with pulmonary tuberculosis. Tubercle and Lung Disease, 73 (5). pp. 280-284. ISSN 0962-8479 Sanjeevi, C B and Seshiah, V (1989) Insulin and Insulin Antibody: What a Family Physician should Know ? Journal of General Medicine, 1 (3). pp. 47-49. ...
Omega ResearchOmega Research
We performed a nested case-control analysis within the Finnish Type 1 Diabetes Prediction and Prevention Study birth cohort, carrying HLA-conferred susceptibility to type 1 diabetes (n = 7782). Serum total fatty acid composition was analysed by gas chromatography in 240 infants with islet autoimmunity and 480 control infants at the age of 3 and 6 months. Islet autoimmunity was defined as repeated positivity for islet cell autoantibodies in combination with at least one of three selected autoantibodies. In addition, a subset of 43 infants with primary insulin autoimmunity (i.e. those with insulin autoantibodies as the first autoantibody with no concomitant other autoantibodies) and a control group (n = 86) were analysed. A third endpoint was primary GAD autoimmunity defined as GAD autoantibody appearing as the first antibody without other concomitant autoantibodies (22 infants with GAD autoimmunity; 42 infants in control group). Conditional logistic regression was applied, considering multiple ...
Islet Autoantibodies in Diabetes | Lab Tests OnlineIslet Autoantibodies in Diabetes | Lab Tests Online
Learn about testing for islet autoantibodies, used to identify people at increased risk for developing type 1 diabetes or requiring insulin treatment
Maternal type 1 diabetes reduces the risk of islet autoantibodies: relationships with | Children with Diabetes ForumsMaternal type 1 diabetes reduces the risk of islet autoantibodies: relationships with | Children with Diabetes Forums
Diabetologia. 2008 Jul;51(7):1245-52. Epub 2008 May 8.[IMG] Links Maternal type 1 diabetes reduces the risk of islet autoantibodies: relationships...
Porcine Insulin INS-41P - Creative BioMartPorcine Insulin INS-41P - Creative BioMart
Porcine Insulin produced inPorcine Pancreasis a two chain, glycosylated polypeptide chain containing 51 amino acids and having a molecular mass of 5777 Dalton. The α and β chains are joined by two interchain disulfide bonds. The α chain contains an intrac
Anti-Insulin degrading enzyme / IDE抗体[EPR6099]Anti-Insulin degrading enzyme / IDE抗体[EPR6099]
Insulin degrading enzyme / IDE兔单克隆抗体[EPR6099](ab109538)可与小鼠, 大鼠, 人样本反应并经WB, ICC实验严格验证。所有产品均提供质保服务，中国75%以上现货。
Click to printClick to print
In a pilot study that included children at high risk for type 1 diabetes, daily high-dose oral insulin, compared with placebo, resulted in an immune response to insulin without hypoglycemia. According to the researchers, the findings that support the need for a phase 3 trial to determine whether oral insulin can prevent islet autoimmunity and diabetes in high-risk children, according to a study in the April 21 issue of JAMA.. A few specific proteins are often the trigger for immune responses that cause autoimmune diseases. This has led to the experimental use of antigen-specific therapies (using a substance to initiate an immune response) to prevent, stabilize, or reverse immune-related diseases, such as allergies and multiple sclerosis.. Type 1 diabetes is an autoimmune disease that can be detected in asymptomatic individuals by the presence of islet autoantibodies that develop in children. Antigen-specific therapy using insulin before the development of autoantibodies may induce protective ...
Anti-insulin antibodies are a cause of hypoglycemia following pancreas transplantation<...Anti-insulin antibodies are a cause of hypoglycemia following pancreas transplantation<...
TY - JOUR. T1 - Anti-insulin antibodies are a cause of hypoglycemia following pancreas transplantation. AU - Tran, Minou P.. AU - Larsen, Jennifer Lynn. AU - Duckworth, William C.. AU - Ruby, Elizabeth I.. AU - Miller, Suzanne A.. AU - Frisbie, Kecia. AU - Taylor, Rodney J.. AU - Stratta, Robert J.. PY - 1994/9. Y1 - 1994/9. N2 - OBJECTIVE - Hypoglycemic symptoms have been reported by more than half of pancreas transplantation (PTX) recipients. To better understand the mechanism for the hypoglycemia documented in some of these patients, we studied the glucose and pancreatic hormone response to Sustacal in patients with and without hypoglycemia following PTX. RESEARCH DESIGN AND METHODS - Twelve patients with established, repeated episodes of hypoglycemia following PTX (hypo) were case-matched to PTX recipients without hypoglycemic symptoms (control; n = 7). On the day of the study, fasting glucose, free and total immunoreactive insulin (IRI), C-peptide, proinsulin, and glucagon were drawn (time ...
Diagnosis and Treatment of Diabetic Patients Requiring Insulin Who Repeatedly Manifest Hyperglycemia and Hypoglycemia Due to...Diagnosis and Treatment of Diabetic Patients Requiring Insulin Who Repeatedly Manifest Hyperglycemia and Hypoglycemia Due to...
Although anti-insulin antibodies (IAs) are often observed in patients treated with general regimens of insulin, their existence is not thought to be related to hypoglycemia.1 However, IA-positive patients treated with human insulin may manifest unexplainable hypoglycemia.2-5 The IAs of these patients have a lower affinity and a higher binding capacity than those from patients with insulin autoimmune syndrome (IAS)6 or those who do not develop hypoglycemia when treated with insulin. Ceasing insulin administration2 and switching to insulin analogs,3 steroid therapy,4 or double filtration plasmapheresis (DFPP)5 are all therapies that have been advocated to treat such patients.. Recently, we described analog insulin-receiving patients who developed severe daytime hyperglycemia and morning hypoglycemia associated with IA formation.7 Such cases seem to be augmenting with the spread of insulin analog treatment, and, unfortunately, they did not appear to respond well to the aforementioned therapies. ...
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Plasma free insulin profiles in insulin-dependent diabetic subjects were compared after jet and syringe injection of insulin. Jet injection of insulin resulted in a shift of the free insulin profile to the left. Thus higher plasma free insulin levels were found over the first 30 min after injection (P , 0.05), while after 240 min plasma free insulin levels were lower than those seen following syringe injection (P , 0.05). Significant differences in the response of blood glucose and 3-hydroxybutyrate levels reflected the differences in plasma free insulin levels. Jet administration results in more rapid absorption of insulin and could be useful in providing a more physiologic postprandial insulin profile than that seen after conventional injection.. ...
anti-Insulin Receptor antibody | GeneTexanti-Insulin Receptor antibody | GeneTex
Insulin Receptor antibody (insulin receptor) for IHC-P, WB. Anti-Insulin Receptor pAb (GTX101136) is tested in Human, Mouse, Rat samples. 100% Ab-Assurance.
Zn2+ chelation by serum albumin improves hexameric Zn2+-insulin dissociation into monomers after exocytosis. | Physicians...Zn2+ chelation by serum albumin improves hexameric Zn2+-insulin dissociation into monomers after exocytosis. | Physician's...
β-cells release hexameric Zn2+-insulin into the extracellular space, but monomeric Zn2+-free insulin appears to be the only biologically active form. The mechanisms implicated in dissociation of the hexamer remain unclear, but they seem to be Zn2+ concentration-dependent. In this study, we investigate the influence of albumin binding to Zn2+ on Zn2+-insulin dissociation into Zn2+-free insulin and its physiological, methodological and therapeutic relevance. Glucose and K+-induced insulin release were analyzed in isolated mouse islets by static incubation and perifusion experiments in the presence and absence of albumin and Zn2+ chelators. Insulin tolerance tests were performed in rats using different insulin solutions with and without Zn2+ and/or albumin. Albumin-free buffer does not alter quantification by RIA of Zn2+-free insulin but strongly affects RIA measurements of Zn2+-insulin. In contrast, accurate determination of Zn2+-insulin was obtained only when bovine serum albumin or Zn2+ ...
Development of type 1 Diabetes in Wild Bank Voles Associated With Islet Autoantibodies and the Novel Ljungan VirusDevelopment of type 1 Diabetes in Wild Bank Voles Associated With Islet Autoantibodies and the Novel Ljungan Virus
2003 (English)In: International journal of experimental diabetes research, Vol. 4, p. 35-44Article in journal (Refereed) Published ...
6.1.1 Insulins6.1.1 Insulins
For those patients who require animal insulin the Hypurin® range is available. For safety the insulin prescription for any person should be consistent, stating the species (if not human), the proprietary name, whether a vial, cartridge or pen is needed and, for premixed insulins, the ratio of the two types of insulin. Hypurin® Bovine Insulin is being discontinued, due to global raw material unavailability. All patients currently using any Hypurin® Bovine Insulin will need to have their insulin prescription changed. This does not affect the supply of Porcine insulin. Further details can be found on the manufacturers website. ...
Product Overview | InsudexInsudexProduct Overview | InsudexInsudex
Insulin Autoantibodies to insulin (IAA) can predict risk of type-1 diabetes or confirm a diagnosis of type-1 diabetes. IAA are most common in children with or at risk for type-1 diabetes.. GAD, GAD65 Autoantibodies to GAD (GADA), like IAA, are also predictive of risk for type-1 diabetes. GAD autoantibodies are present in the majority of adult patients with autoimmune diabetes.. IA-2 Autoantibodies against IA-2 (IA2-A) are the second most common autoantibody in type-1 diabetes. GAD and IA-2 autoantibodies are the most common in type-2 diabetes that also has an autoimmune component.. For children, the number of autoantibodies present is a better predictor of disease risk than the presence of any single antibody.. ...
Anti-Insulin Receptor AntibodyAnti-Insulin Receptor Antibody
Polyclonal antibody for INSULIN RECEPTOR/INSR detection. Host: Rabbit.Size: 100μg/vial. Tested applications: WB. Reactive species: Human. INSULIN RECEPTOR/INSR information: Molecular Weight: 156333 MW; Subcellular Localization: Cell membrane; Single-pass
New data on islet autoantibodies in young children defines early type 1 diabetes d... ( New York NY June 19 2013 A decade-l.....New data on islet autoantibodies in young children defines early type 1 diabetes d... ( New York NY June 19 2013 A decade-l.....
...New York NY June 19 2013 A decade-long JDRF-funded study led by th...Researchers in Colorado (DAISY study) Finland (DIPP study) and Germa... This is the first true estimate from when we think the process of typ...,New,data,on,islet,autoantibodies,in,young,children,defines,early,type,1,diabetes,development,biological,biology news articles,biology news today,latest biology news,current biology news,biology newsletters
Oramed Enrolls First Patient in its Phase 2a U.S. Oral Insulin Clinical Trial | FiercePharmaOramed Enrolls First Patient in its Phase 2a U.S. Oral Insulin Clinical Trial | FiercePharma
Oramed Enrolls First Patient in its Phase 2a U.S. Oral Insulin Clinical Trial Marks initiation of Orameds first FDA trial for its flagship ORMD-0801 oral insulin product JERUSALEM, July 8, 2013...
ISLET Cell Antibody - Apollo DiagnosticsISLET Cell Antibody - Apollo Diagnostics
My mother needed a blood test, but was unable to walk due to pain in her leg. A Phlebotomist from Apollo Diagnostics came home and collected the sample. I was informed, via SMS, that the report could be collected from any of the 3 centres in Dibrugarh, downloaded online or even delivered home for a nominal fee. Although the rates were reasonable, my mother also received a senior citizens discount too! This saved my time, money & energy. My aachhe din really seemed to have arrived! Thank you Apollo Diagnostics and hats off for displaying true professionalism.". Mr. Alokk Kar Dowerah, Dibrugarh ...
CHILDHOOD DIABETES MELLITUSCHILDHOOD DIABETES MELLITUS
University of Babylon is devoted to excellence in teaching, learning, and research, University of Babylon is made up of 19 Faculty of academy.
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Affinity chromatographyAffinity chromatography
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Latent autoimmune diabetes in adultsLatent autoimmune diabetes in adults
Gluten-sensitive enteropathy-associated conditionsGluten-sensitive enteropathy-associated conditions
The Environmental Determinants of Diabetes in the YoungThe Environmental Determinants of Diabetes in the Young
Kiran Mazumdar-ShawKiran Mazumdar-Shaw
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List of MeSH codes (D12.776)List of MeSH codes (D12.776)
TranscytosisTranscytosis
Type 2 diabetesType 2 diabetes
Hematopoietic stem cell transplantationHematopoietic stem cell transplantation
LevothyroxineLevothyroxine
AfatinibAfatinib
HLA A1-B8-DR3-DQ2HLA A1-B8-DR3-DQ2
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Ephrin A5Ephrin A5
Brutons tyrosine kinaseBruton's tyrosine kinase
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Diabetes mellitus type 1Diabetes mellitus type 1
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Major histocompatibility complex, class II, DQ alpha 1Major histocompatibility complex, class II, DQ alpha 1
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Insulin AntibodiesBiphasic InsulinsBromouracilInsulinChlorpropamidePhenforminInsulin, IsophaneAntibodiesInsulin AspartHypoglycemiaReceptor, InsulinComplement Activating EnzymesDiabetes Mellitus, Type 1Antibody SpecificityAntigen-Antibody ComplexAntibodies, ViralDiabetes MellitusAntibodies, BacterialAntibodies, MonoclonalRadioimmunoassayInsulin ResistanceAntibody FormationAntibodies, NeutralizingAntibody AffinityInsulin Receptor Substrate ProteinsProinsulinC-PeptideMolecular Sequence DataCetirizineLoveHistamine H1 Antagonists, Non-SedatingSister Mary Joseph's NoduleUmbilicusHistamine H1 AntagonistsBlood GlucoseNesidioblastosisLuminescent MeasurementsImmunoassayLuminescencePeriodicals as TopicMagneticsMagnetsGraves OphthalmopathyGraves DiseaseReceptor, IGF Type 1DiplopiaInsulin-Like Growth Factor IExophthalmosInsulin AntagonistsAutoantibodiesChromatography, AffinityRecombinant ProteinsAmino Acid SequenceChromatography, High Pressure LiquidChromatography, GelKinetics
Insulin Detection: AntibodiesInsulin Detection: Antibodies
Anti-Insulin antibody (ab53591) | AbcamAnti-Insulin antibody (ab53591) | Abcam
RE: [IPk] Insulin antibodies and tape allergyRE: [IPk] Insulin antibodies and tape allergy
anti-Insulin antibody | GeneTexanti-Insulin antibody | GeneTex
Insulin AntibodiesInsulin Antibodies
Insulin Antibodies | Private Blood TestsInsulin Antibodies | Private Blood Tests
Insulin Antibodies, Serum - Meriter LaboratoriesInsulin Antibodies, Serum - Meriter Laboratories
Insulin Antibodies, Serum - Barnes-Jewish HospitalInsulin Antibodies, Serum - Barnes-Jewish Hospital
Anti-Insulin Antibodies - Process-Related Impurity Antibodies - Antibodies - ProductsAnti-Insulin Antibodies - Process-Related Impurity Antibodies - Antibodies - Products
Isotypic and idiotypic analysis of murine anti-insulin antibodies. Ab by P F. Robbins and J A. Kapp"Isotypic and idiotypic analysis of murine anti-insulin antibodies. Ab" by P F. Robbins and J A. Kapp
Insulin autoimmune syndrome: case reportInsulin autoimmune syndrome: case report
Aerosol Insulin Induces Regulatory CD8 γδ T Cells That Prevent Murine Insulin-dependent Diabetes | Journal of Experimental...Aerosol Insulin Induces Regulatory CD8 γδ T Cells That Prevent Murine Insulin-dependent Diabetes | Journal of Experimental...
Total and Free Insulin (Blood)Total and Free Insulin (Blood)
Insulin AntibodyInsulin Antibody
Anti-insulin antibody test: MedlinePlus Medical EncyclopediaAnti-insulin antibody test: MedlinePlus Medical Encyclopedia
Insulin, EIA/ELISA, Parainfluenza antibodiesInsulin, EIA/ELISA, Parainfluenza antibodies
Insulin antibodies in insulin-dependent diabetics before insulin treatment | ScienceInsulin antibodies in insulin-dependent diabetics before insulin treatment | Science
Insulin R/CD220 Antibodies: Novus BiologicalsInsulin R/CD220 Antibodies: Novus Biologicals
Antibodies to post-translationally modified insulin in type 1 diabetes. | Sigma-AldrichAntibodies to post-translationally modified insulin in type 1 diabetes. | Sigma-Aldrich
Anti-Insulin Receptor alpha antibody (ab5500) | AbcamAnti-Insulin Receptor alpha antibody (ab5500) | Abcam
Product Overview anti-Insulin AntibodiesProduct Overview anti-Insulin Antibodies
Insulin AntibodiesInsulin Antibodies
regulation of insulin secretion Antibodies | Invitrogen ...regulation of insulin secretion Antibodies | Invitrogen ...
Anti-Insulin Receptor Antibodies and Diabetes | Annals of Internal Medicine | American College of PhysiciansAnti-Insulin Receptor Antibodies and Diabetes | Annals of Internal Medicine | American College of Physicians
Insulin Antibody (NBP1-50246): Novus BiologicalsInsulin Antibody (NBP1-50246): Novus Biologicals
Anti-Insulin Receptor alpha antibody [83-7] (ab36550) | AbcamAnti-Insulin Receptor alpha antibody [83-7] (ab36550) | Abcam
CST - Insulin/IGF-1 Signaling Pathway Antibody Sampler KitCST - Insulin/IGF-1 Signaling Pathway Antibody Sampler Kit
Insulin ELISA Kits | www.antibodies-online.comInsulin ELISA Kits | www.antibodies-online.com
Autoimmune Hypoglycemia in a Type 2 Diabetic Patient With Anti-Insulin and Insulin Receptor Antibodies | Diabetes CareAutoimmune Hypoglycemia in a Type 2 Diabetic Patient With Anti-Insulin and Insulin Receptor Antibodies | Diabetes Care
Fully automated chemiluminescence immunoassay of insulin using antibody-protein A-bacterial magnetic particle complexes. -...Fully automated chemiluminescence immunoassay of insulin using antibody-protein A-bacterial magnetic particle complexes. -...
Special Survey of Production of Insulin Aspart Specific Antibody - Full Text View - ClinicalTrials.govSpecial Survey of Production of Insulin Aspart Specific Antibody - Full Text View - ClinicalTrials.gov
A Woman with Diabetes Mellitus Complicated by Insulin Antibody InteractionsA Woman with Diabetes Mellitus Complicated by Insulin Antibody Interactions
Antibodies to Insulin Receptor Followed by Anti-Idiotype: Antibodies to Insulin in Child With Hypoglycemia | DiabetesAntibodies to Insulin Receptor Followed by Anti-Idiotype: Antibodies to Insulin in Child With Hypoglycemia | Diabetes
Effect of Insulin Antibodies on Insulin Pharmacokinetics and Glucose Utilization in Insulin-dependent Diabetic Patients |...Effect of Insulin Antibodies on Insulin Pharmacokinetics and Glucose Utilization in Insulin-dependent Diabetic Patients |...
Insulin receptor antibody | definition of insulin receptor antibody by Medical dictionaryInsulin receptor antibody | definition of insulin receptor antibody by Medical dictionary
insulin-like growth factor receptor signaling pathway Antibodies | Invitrogen ...insulin-like growth factor receptor signaling pathway Antibodies | Invitrogen ...
Production and characterization of monoclonal antibodies to insulin secretory granule membranes | Biochemical Journal |...Production and characterization of monoclonal antibodies to insulin secretory granule membranes | Biochemical Journal |...
Anti-insulin-like Growth Factor-1 Receptor (IGF-1R) Antibodies in Graves' Disease and Graves' Orbitopathy - Full Text...Anti-insulin-like Growth Factor-1 Receptor (IGF-1R) Antibodies in Graves' Disease and Graves' Orbitopathy - Full Text...
Islet cell and glutamic acid decarboxylase antibodies present at diagnosis of diabetes predict the need for insulin treatment....Islet cell and glutamic acid decarboxylase antibodies present at diagnosis of diabetes predict the need for insulin treatment....
AnatomyDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and ProcessesDisciplines and OccupationsTechnology, Industry, AgricultureInformation Science
Insulin AntibodiesBiphasic InsulinsBromouracilInsulinChlorpropamidePhenforminInsulin, IsophaneAntibodiesInsulin AspartHypoglycemiaReceptor, InsulinComplement Activating EnzymesDiabetes Mellitus, Type 1Antibody SpecificityAntigen-Antibody ComplexAntibodies, ViralDiabetes MellitusAntibodies, BacterialAntibodies, MonoclonalRadioimmunoassayInsulin ResistanceAntibody FormationAntibodies, NeutralizingAntibody AffinityInsulin Receptor Substrate ProteinsProinsulinC-PeptideMolecular Sequence DataCetirizineLoveHistamine H1 Antagonists, Non-SedatingSister Mary Joseph's NoduleUmbilicusHistamine H1 AntagonistsBlood GlucoseNesidioblastosisLuminescent MeasurementsImmunoassayLuminescencePeriodicals as TopicMagneticsMagnetsGraves OphthalmopathyGraves DiseaseReceptor, IGF Type 1DiplopiaInsulin-Like Growth Factor IExophthalmosInsulin AntagonistsAutoantibodiesChromatography, AffinityRecombinant ProteinsAmino Acid SequenceChromatography, High Pressure LiquidChromatography, GelKinetics
Anti-Insulin AntibodiesPancreasCharacterized by insulin-requiReactivityPancreaticBovineDiabetesEpitopeIsletIDDM2ProinsulinRecombinantHumanAdvance your diagnostic and therapeuticBlood glucoseMonoclonal antibodiesSerumAutoantibodiesDiabetesBinding proteinProteinsReceptor AntibodiesAnti-insulin receptor antibodyImmunogenMouse monoclonal antibodyPurificationSpecificityGlucoseExogenous insulinCloneImmunohistochemistryIgG1Primary antibodySecondary antibodyAffinityAlpha antibodyReceptorsCatalogPhosphorylationAssaysWestern BlotIslet cell antibodyAspartImmunoreactive insulinImmunofluorescenceGrowth Factor-1 ReceptorIRDNAntigensHormoneINSRDetectionPolypeptideLocalizationPathwaysAutoimmune syndrome
Anti-Insulin Antibodies2
Pancreas1
Characterized by insulin-requi1
  • It is characterized by insulin-requiring hyperglycemia that is diagnosed within the first months of life. (abcam.com)
Reactivity1
  • Several potentially pathogenic islet/β cell autoantigens have been identified by their reactivity with circulating antibodies or T cells in rodents and humans with subclinical or clinical IDDM, particularly insulin, glutamic acid decarboxylase (GAD), and a tyrosine phosphatase, IA-2 ( 9 ). (rupress.org)
Pancreatic1
  • When we administered insulin aerosol to NOD mice after the onset of subclinical disease, pancreatic islet pathology and diabetes incidence were both significantly reduced. (rupress.org)
Bovine1
Diabetes4
  • Defects in INS are a cause of diabetes mellitus insulin-dependent type 2 (IDDM2) [MIM: (abcam.com)
  • MODY10 is a form of diabetes that is characterized by an autosomal dominant mode of inheritance, onset in childhood or early adulthood (usually before 25 years of age), a primary defect in insulin secretion and frequent insulin-independence at the beginning of the disease. (abcam.com)
  • Insulin is an autoantigen in humans and nonobese diabetic (NOD) mice with insulindependent diabetes mellitus (IDDM). (rupress.org)
  • The ability of splenocytes from insulin-treated mice to suppress the adoptive transfer of diabetes to nondiabetic mice by T cells of diabetic mice was shown to be caused by small numbers of CD8 γδ T cells. (rupress.org)
Epitope1
  • Insulin-treated mice had increased circulating antibodies to insulin, absent splenocyte proliferation to the major epitope, insulin B chain amino acids 9-23, which was associated with increased IL-4 and particularly IL-10 secretion, and reduced proliferation to glutamic acid decarboxylase, another islet autoantigen. (rupress.org)
Islet1
IDDM21
  • IDDM2 is a multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. (abcam.com)
Proinsulin1
Recombinant1
Human1
  • Induction of regulatory CD8 γδ T cells by aerosol insulin is a therapeutic strategy with implications for the prevention of human IDDM. (rupress.org)
Advance your diagnostic and therapeutic1
Blood glucose1
Monoclonal antibodies9
Serum8
Autoantibodies7
Diabetes46
Binding protein1
Proteins11
  • Antibodies are proteins the body produces to protect itself when it detects anything "foreign," such as a virus or transplanted organ. (medlineplus.gov)
  • Search, Find and Buy Antibodies, ELISA Kits and Proteins. (antibodies-online.com)
  • Three adapter proteins, IRS1, IRS2 and Shc, become phosphorylated on tyrosine residues following insulin receptor activation. (abcam.com)
  • The specificities of the antibodies were investigated by using binding assays with different insulinoma subcellular fractions, by indirect immunofluorescence studies with intact and permeabilized cells, and by immunoblotting of granule membrane proteins fractionated by SDS/polyacrylamide-gel electrophoresis. (portlandpress.com)
  • Biosynthesis of insulin secretory granule membrane proteins. (portlandpress.com)
  • Affinity chromatography is an efficient method to isolate proteins by taking advantage of their affinities for specific molecules such as substrates, inhibitors, antigens, ligands, antibodies, and other interacting molecules, including subunits. (frontiersin.org)
  • Later in my career, I used commercially available affinity columns and beads, which specifically bind to tags or fusion proteins designed for purification of antibodies and recombinant proteins (Table 1 ) ( 6 - 11 ). (frontiersin.org)
  • The protein encoded by this gene is similar to insulin in function and structure and is a member of a family of proteins involved in mediating growth and development. (acris-antibodies.com)
  • Check out links to articles that cite our custom service antibodies, peptides, and proteins in major peer-reviewed journals, organized by research category. (abgent.com)
  • Phosphorylation of IRSs proteins lead to the activation of two main signaling pathways: the PI3K-AKT/PKB pathway, which is responsible for most of the metabolic actions of insulin, and the Ras-MAPK pathway, which regulates expression of some genes and cooperates with the PI3K pathway to control cell growth and differentiation. (bosterbio.com)
  • Synthetic peptides, native or recombinant proteins can be used for medical, academic and research purposes, such as gene therapy, drug screening, antibody production, cell function analysis. (abbkine.com)
Receptor Antibodies2
Anti-insulin receptor antibody3
Immunogen2
Mouse monoclonal antibody2
Purification1
Specificity2
  • The sensitivity for later insulin treatment was highest (74%) for the presence of ICA or GADA, and the specificity was highest (100%) for ICA and GADA. (diabetesjournals.org)
  • Antibodies are useful not only to detect specific biomolecules but also to measure changes in their level and specificity of modification by processes such as phosphorylation, methylation, or glycosylation. (abbkine.com)
Glucose16
  • Insulin decreases blood glucose concentration. (abcam.com)
  • IDDM2 is a multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. (abcam.com)
  • Insulin enhances membrane transport of glucose, amino acids, and certain ions. (novusbio.com)
  • Her plasma glucose was 40 mg/dl, insulin 103.7 μU/ml, and C-peptide 4.1 ng/ml. (diabetesjournals.org)
  • antibody to beef insulin when injected into mice produced as many convulsions and lowered the blood glucose to the same mean level as did 50 mU. (diabetesjournals.org)
  • antibody did not convulse and had a mean blood glucose of 108 mg./100 ml. (diabetesjournals.org)
  • Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. (genetex.com)
  • Thus, we set out to define the clinical characteristics of these patients who generated IAs and manifested unexplainable fluctuations in blood glucose levels while receiving insulin analogs and to determine how best to treat them. (diabetesjournals.org)
  • Insulin is a pancreatic hormone that regulates glucose uptake and the synthesis of protein and fat. (immuquest.com)
  • CONCLUSIONS - The lower fasting free/total IRI ratio and greater increase in glucose and total IRI in response to Sustacal in the hypo-high group compared with either the hypo-flat or control groups are consistent with the presence of significant quantities of anti-insulin antibodies in the hypo-high group. (elsevier.com)
  • This leads to higher insulin levels and more rapid tissueassimilation of glucose followed by a decline in the insulin level as the glucose level subsides. (abbkine.com)
  • Most pets are prescribed long acting insulin medication that controls blood glucose for a longer period of time. (vetinfo.com)
  • Lab tests include the plasma glucose level, the fasting insulin level, and a lipid profile, among others. (medscape.com)
  • [ 12 ] Given that glucose and lipid metabolism largely depend on mitochondria to generate energy in cells, mitochondrial dysfunction may play an important role in the development of insulin resistance and associated complications. (medscape.com)
  • These data demonstrated otelixizumab's ability to preserve beta cell function, as measured by C-peptide, in patients up to 18 months after dosing, as well as reduce the need for delivered insulin to maintain glucose control. (wikipedia.org)
  • The trial was designed to evaluate whether a single course of otelixizumab, administered not more than 90 days after the initial diagnosis, would reduce the amount of administered insulin required to control blood glucose levels by inhibiting the destruction of beta cells. (wikipedia.org)
Exogenous insulin1
Clone1
Immunohistochemistry1
  • Abgent's experienced staff custom validates more than 1,000 antibodies each month in Western Blot (WB), Immunofluorescence (IF), Immunohistochemistry (IHC), Flow Cytometry (FC) and additional applications. (abgent.com)
IgG11
  • The most potent neutralizer, IgG1 m610, inhibited phosphorylation of the IGF-IR and the insulin receptor, as well as phosphorylation of the downstream kinases Akt and mitogen-activated protein kinase with an IC 50 of the order of 1 nmol/L at IGF-II concentration of 10 nmol/L. It also inhibited growth of the prostate cancer cell line DU145 and migration of the breast cancer line cells MCF-7. (aacrjournals.org)
Primary antibody4
Secondary antibody3
Affinity5
  • Although IR-A and IR-B have similar affinities for insulin, IR-A exhibits higher affinity for IGF-II than IR-B ( 21 ). (aacrjournals.org)
  • They bound with high (subnanomolar) affinity to IGF-II, did not cross-react with IGF-I and insulin, and potently inhibited signal transduction mediated by the IGF-IR interaction with IGF-II. (aacrjournals.org)
  • 2 - 5 The IAs of these patients have a lower affinity and a higher binding capacity than those from patients with insulin autoimmune syndrome (IAS) 6 or those who do not develop hypoglycemia when treated with insulin. (diabetesjournals.org)
  • Ambient insulin levels, various physiologic and disease states, and drugs regulate insulin receptor concentration or affinity. (medscape.com)
  • Antibodies in 3 diabetic patients and 7 non-diabetic control subjects were purified using protein-G sepharose affinity column chromatography and S-300 gel filtration methods purity of the IgG antibodies was confirmed by SDS-PAGE and in western blot analysis and proteolytic activity of electrophoretically homogenous IgG antibodies was confirmed with zymogram analysis. (ac.ir)
Alpha antibody1
Receptors2
Catalog1
Phosphorylation9
Assays5
Western Blot5
Islet cell antibody2
Aspart3
Immunoreactive insulin1
Immunofluorescence1
  • The most specific and sensitive of these, the antiendomysial antibody, is the indirect immunofluorescence test which uses monkey esophagus smooth muscle as substrate. (nih.gov)
Growth Factor-1 Receptor1
IRDN1
Antigens1
Hormone2
INSR1
Detection2
Polypeptide3
Localization1
Pathways1
Autoimmune syndrome2
  • Burch HB, Clement S, Sokol MS, Landry F: Reactive hypoglycemic coma due to insulin autoimmune syndrome: case report and literature review. (diabetesjournals.org)
  • Insulin autoimmune syndrome (IAS) is a rare cause of hyperinsulinaemic hypoglycaemia, whose prevalence is higher in East Asian populations due to the higher prevalence of specific immunogenetic determinants. (bioscientifica.com)
Anti-Insulin antibody (ab53591) | Abcam
Anti-Insulin antibody (ab53591) | Abcam (abcam.com)
New Insulin Glargine 300 Units/mL Versus Glargine 100 Units/mL in People With Type 1 Diabetes: A Randomized, Phase 3a, Open...
New Insulin Glargine 300 Units/mL Versus Glargine 100 Units/mL in People With Type 1 Diabetes: A Randomized, Phase 3a, Open... (care.diabetesjournals.org)
Anti-Insulin Receptor Antibodies and Diabetes | Annals of Internal Medicine | American College of Physicians
Anti-Insulin Receptor Antibodies and Diabetes | Annals of Internal Medicine | American College of Physicians (annals.org)
Special Survey of Production of Insulin Aspart Specific Antibody - Full Text View - ClinicalTrials.gov
Special Survey of Production of Insulin Aspart Specific Antibody - Full Text View - ClinicalTrials.gov (clinicaltrials.gov)
The cation efflux transporter ZnT8 (Slc30A8) is a major autoantigen in human type 1 diabetes | PNAS
The cation efflux transporter ZnT8 (Slc30A8) is a major autoantigen in human type 1 diabetes | PNAS (pnas.org)
JISCMail - ACB-CLIN-CHEM-GEN Archives - November 2016
JISCMail - ACB-CLIN-CHEM-GEN Archives - November 2016 (jiscmail.ac.uk)
Anti-insulin antibody test: MedlinePlus Medical Encyclopedia
Anti-insulin antibody test: MedlinePlus Medical Encyclopedia (medlineplus.gov)
Insulin Resistance Treatment
Insulin Resistance Treatment (news-medical.net)
The Role of Viruses and the Immune System in Diabetes Mellitus | SpringerLink
The Role of Viruses and the Immune System in Diabetes Mellitus | SpringerLink (link.springer.com)
Product Search for insulin receptor alpha: Novus Biologicals
Product Search for insulin receptor alpha: Novus Biologicals (novusbio.com)
Infant Formula | GreenMedInfo | Toxic Ingredient | Natural Medicine
Infant Formula | GreenMedInfo | Toxic Ingredient | Natural Medicine (greenmedinfo.com)
Diabetes Mellitus: Type 1: Prevention | GreenMedInfo | Disease
Diabetes Mellitus: Type 1: Prevention | GreenMedInfo | Disease (greenmedinfo.com)
Biological Drug API Manufacturing Services World Industry and Market Forecast to 2029 - Visiongain
Biological Drug API Manufacturing Services World Industry and Market Forecast to 2029 - Visiongain (visiongain.com)
Nonsurgical Periodontal Treatment Did Not Result in Improved Glycemic Control for Diabetics
Nonsurgical Periodontal Treatment Did Not Result in Improved Glycemic Control for Diabetics (medindia.net)
Levemir (Insulin Detemir): Uses, Dosage, Side Effects, Interactions, Warning
Levemir (Insulin Detemir): Uses, Dosage, Side Effects, Interactions, Warning (rxlist.com)
Vitamin D and diabetes | SpringerLink
Vitamin D and diabetes | SpringerLink (link.springer.com)
Plus it
Plus it (diabetes.diabetesjournals.org)
A series of posts about virology - Airliners.net
A series of posts about virology - Airliners.net (airliners.net)
Insulin-like growth factor 2 - Wikipedia
Insulin-like growth factor 2 - Wikipedia (en.wikipedia.org)
Frontiers | T Cell-Mediated Beta Cell Destruction: Autoimmunity and Alloimmunity in the Context of Type 1 Diabetes |...
Frontiers | T Cell-Mediated Beta Cell Destruction: Autoimmunity and Alloimmunity in the Context of Type 1 Diabetes |... (frontiersin.org)
Oral insulin protects high risk children from type 1 diabetes in first study | EmaxHealth
Oral insulin protects high risk children from type 1 diabetes in first study | EmaxHealth (emaxhealth.com)
Free Laboratory Science Flashcards about Cytology/Specimen
Free Laboratory Science Flashcards about Cytology/Specimen (studystack.com)
Insulin-like Growth Factors
Insulin-like Growth Factors (news-medical.net)
Insulin Degludec Versus Insulin Glargine in Insulin-Naive Patients With Type 2 Diabetes | Diabetes Care
Insulin Degludec Versus Insulin Glargine in Insulin-Naive Patients With Type 2 Diabetes | Diabetes Care (care.diabetesjournals.org)
Rebecca J. Brown, M.D., M.H.Sc., Lasker Tenure Track Investigator | NIDDK
Rebecca J. Brown, M.D., M.H.Sc., Lasker Tenure Track Investigator | NIDDK (niddk.nih.gov)
Plus it
Plus it (care.diabetesjournals.org)
How the immunoassay transformed C-peptide from a duckling into a swan | SpringerLink
How the immunoassay transformed C-peptide from a duckling into a swan | SpringerLink (link.springer.com)
High OGTT - No antibodies - Page 4
High OGTT - No antibodies - Page 4 (diabetesdaily.com)
Olfactory receptors are expressed in pancreatic β-cells and promote glucose-stimulated insulin secretion | Scientific Reports
Olfactory receptors are expressed in pancreatic β-cells and promote glucose-stimulated insulin secretion | Scientific Reports (nature.com)