The instillation or other administration of drugs into the bladder, usually to treat local disease, including neoplasms.
Tumors or cancer of the URINARY BLADDER.
A musculomembranous sac along the URINARY TRACT. URINE flows from the KIDNEYS into the bladder via the ureters (URETER), and is held there until URINATION.
An antineoplastic antibiotic produced by Streptomyces caespitosus. It is one of the bi- or tri-functional ALKYLATING AGENTS causing cross-linking of DNA and inhibition of DNA synthesis.
An active immunizing agent and a viable avirulent attenuated strain of Mycobacterium tuberculosis, var. bovis, which confers immunity to mycobacterial infections. It is used also in immunotherapy of neoplasms due to its stimulation of antibodies and non-specific immunity.
Inflammation of the URINARY BLADDER, either from bacterial or non-bacterial causes. Cystitis is usually associated with painful urination (dysuria), increased frequency, urgency, and suprapubic pain.
The resistance that a gaseous or liquid system offers to flow when it is subjected to shear stress. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
Genetically developed small pigs for use in biomedical research. There are several strains - Yucatan miniature, Sinclair miniature, and Minnesota miniature.
The organ of sight constituting a pair of globular organs made up of a three-layered roughly spherical structure specialized for receiving and responding to light.
The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.
Application of pharmaceutically active agents on the tissues of the EYE.
Sterile solutions that are intended for instillation into the eye. It does not include solutions for cleaning eyeglasses or CONTACT LENS SOLUTIONS.
Accumulation of a drug or chemical substance in various organs (including those not relevant to its pharmacologic or therapeutic action). This distribution depends on the blood flow or perfusion rate of the organ, the ability of the drug to penetrate organ membranes, tissue specificity, protein binding. The distribution is usually expressed as tissue to plasma ratios.
The transparent, semigelatinous substance that fills the cavity behind the CRYSTALLINE LENS of the EYE and in front of the RETINA. It is contained in a thin hyaloid membrane and forms about four fifths of the optic globe.
The application of drug preparations to the surfaces of the body, especially the skin (ADMINISTRATION, CUTANEOUS) or mucous membranes. This method of treatment is used to avoid systemic side effects when high doses are required at a localized area or as an alternative systemic administration route, to avoid hepatic processing for example.
Protective measures against unauthorized access to or interference with computer operating systems, telecommunications, or data structures, especially the modification, deletion, destruction, or release of data in computers. It includes methods of forestalling interference by computer viruses or so-called computer hackers aiming to compromise stored data.
The privacy of information and its protection against unauthorized disclosure.
Inorganic salts of phosphoric acid.
The administration of therapeutic agents drop by drop, as eye drops, ear drops, or nose drops. It is also administered into a body space or cavity through a catheter. It differs from THERAPEUTIC IRRIGATION in that the irrigate is removed within minutes, but the instillate is left in place.
A ubiquitous sodium salt that is commonly used to season food.
Inorganic compounds that contain potassium as an integral part of the molecule.
Agents that are used to stimulate evacuation of the bowels.
Any liquid or solid preparation made specifically for the growth, storage, or transport of microorganisms or other types of cells. The variety of media that exist allow for the culturing of specific microorganisms and cell types, such as differential media, selective media, test media, and defined media. Solid media consist of liquid media that have been solidified with an agent such as AGAR or GELATIN.
A member of the alkali group of metals. It has the atomic symbol Na, atomic number 11, and atomic weight 23.
Infections resulting from the implantation of prosthetic devices. The infections may be acquired from intraoperative contamination (early) or hematogenously acquired from other sites (late).
The bovine variety of the tubercle bacillus. It is called also Mycobacterium tuberculosis var. bovis.
Prostheses used to partially or totally replace a human or animal joint. (from UMDNS, 1999)
Endoscopic examination, therapy or surgery of the urinary bladder.
A compound produced from succinyl-CoA and GLYCINE as an intermediate in heme synthesis. It is used as a PHOTOCHEMOTHERAPY for actinic KERATOSIS.
The homogeneous mixtures formed by the mixing of a solid, liquid, or gaseous substance (solute) with a liquid (the solvent), from which the dissolved substances can be recovered by physical processes. (From Grant & Hackh's Chemical Dictionary, 5th ed)
The action of a drug that may affect the activity, metabolism, or toxicity of another drug.
A malignant neoplasm derived from TRANSITIONAL EPITHELIAL CELLS, occurring chiefly in the URINARY BLADDER; URETERS; or RENAL PELVIS.
Works about comparative studies to verify the effectiveness of diagnostic, therapeutic, or prophylactic drugs, devices, or techniques determined in phase II studies. During these trials, patients are monitored closely by physicians to identify any adverse reactions from long-term use. These studies are performed on groups of patients large enough to identify clinically significant responses and usually last about three years. This concept includes phase III studies conducted in both the U.S. and in other countries.
A by-product of the destructive distillation of coal used as a topical antieczematic. It is an antipruritic and keratoplastic agent used also in the treatment of psoriasis and other skin conditions. Occupational exposure to soots, tars, and certain mineral oils is known to be carcinogenic according to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985) (Merck Index, 11th ed).
Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)
A procedure involving placement of a tube into the trachea through the mouth or nose in order to provide a patient with oxygen and anesthesia.
Drugs intended for human or veterinary use, presented in their finished dosage form. Included here are materials used in the preparation and/or formulation of the finished dosage form.
Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood.
Health care professionals, technicians, and assistants staffing LABORATORIES in research or health care facilities.
Water swollen, rigid, 3-dimensional network of cross-linked, hydrophilic macromolecules, 20-95% water. They are used in paints, printing inks, foodstuffs, pharmaceuticals, and cosmetics. (Grant & Hackh's Chemical Dictionary, 5th ed)
The misinterpretation of a real external, sensory experience.
A network of cross-linked hydrophilic macromolecules used in biomedical applications.
Usually inert substances added to a prescription in order to provide suitable consistency to the dosage form. These include binders, matrix, base or diluent in pills, tablets, creams, salves, etc.
The thermodynamic interaction between a substance and WATER.
Compounds formed by the joining of smaller, usually repeating, units linked by covalent bonds. These compounds often form large macromolecules (e.g., BIOPOLYMERS; PLASTICS).
Exclusive legal rights or privileges applied to inventions, plants, etc.
Systems for the delivery of drugs to target sites of pharmacological actions. Technologies employed include those concerning drug preparation, route of administration, site targeting, metabolism, and toxicity.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
DNA molecules capable of autonomous replication within a host cell and into which other DNA sequences can be inserted and thus amplified. Many are derived from PLASMIDS; BACTERIOPHAGES; or VIRUSES. They are used for transporting foreign genes into recipient cells. Genetic vectors possess a functional replicator site and contain GENETIC MARKERS to facilitate their selective recognition.
Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.

Larynx vs. esophagus as reflexogenic sites for acid-induced bronchoconstriction in dogs. (1/154)

Bronchoconstriction in asthmatic patients is frequently associated with gastroesophageal reflux. However, it is still unclear whether bronchoconstriction originates from the esophagus or from aspiration of the refluxate into the larynx and larger airway. We compared the effect of repeated esophageal and laryngeal instillations of HCl-pepsin (pH 1.0) on tracheal smooth muscle activity in eight anesthetized and artificially ventilated dogs. Saline was used as control. We used pressure in the cuff of an endotracheal tube (Pcuff) as a direct index of smooth muscle activity at the level of the larger airways controlled by vagal efferents. The Pcuff values of the first 60 s after instillations were averaged, and the difference from the baseline values was evaluated. Changes in Pcuff were significantly greater with laryngeal than with esophageal instillations (P = 0.0166). HCl-pepsin instillation into the larynx evoked greater responses than did saline (P = 0.00543), whereas no differences were detected with esophageal instillations. Repeated laryngeal exposure enhanced the responsiveness significantly (P < 0. 001). Our data indicate that the larynx is more important than the esophagus as a reflexogenic site for the elicitation of reflex bronchoconstriction in response to acidic solutions.  (+info)

Intrapericardial streptokinase in purulent pericarditis. (2/154)

Six consecutive children with proven purulent pericarditis were treated with pericardial irrigation with streptokinase. Mean (SD) 861 (678) ml (range 240-2000) of thick purulent fluid was drained, and five children had complete clearance of the pus within 3-8 days. One child developed intrapericardial haemorrhage with a submitral pseudoaneurysm and underwent patch closure of the neck of the aneurysm as well as anterior pericardiectomy. Follow up of 13 to 30 months revealed no pericardial constriction.  (+info)

Treatment of malignant pericardial effusion with 32P-colloid. (3/154)

Malignant pericardial effusion is usually treated only when signs of cardiac tamponade develop. Several methods of treatment have been reported with an overall response rate of approximately 75%. Since our initial study using intrapericardial 32P-colloid instillation as a treatment modality for pericardial effusion demonstrated a significant higher response rate, this study was conducted to further evaluate the efficacy of intrapericardial 32P-colloid in terms of response rates and duration of remissions. Intrapericardial instillation of 185-370 MBq (5-10 mCi) 32P-colloid in 36 patients with malignant pericardial effusion resulted in a complete remission rate of 94.5% (34 patients) whereas two patients did not respond to treatment due to a foudroyant formation of pericardial fluid. The median duration time was 8 months. No side-effects were observed. These results suggest that intrapericardial instillation of 32P-colloid is a simple, reliable and safe treatment strategy for patients with malignant pericardial effusions. Therefore, since further evidence is provided that 32P-colloid is significantly more effective than external radiation or non-radioactive sclerosing agents, this treatment modality should be considered for the management of malignant pericardial effusion.  (+info)

Suppressive activity of a macrolide antibiotic, roxithromycin, on pro-inflammatory cytokine production in vitro and in vivo. (4/154)

This study was designed to examine the influence of a macrolide antibiotic, roxithromycin (RXM), on the production of pro-inflammatory cytokines, interleukin (IL)-1beta and tumor necrosis factor (TNF)-alpha. In the first experiments, we examined the effect of RXM on in vitro cytokine production from lipopolysaccharide (LPS)-stimulated human peripheral blood monocytes. The monocytes were cultured in the presence of various doses of the agent. After 24 h, the culture supernatants were obtained and assayed for IL-1beta and TNF-alpha contents by enzyme-linked immunosorbent assay. RXM suppressed the in vitro production of IL-1beta and TNF-alpha in response to LPS stimulation. This was dose dependent and first noted at a concentration of as little as 0.05 microg/ml, which is much lower than therapeutic blood levels. In the second part of the experiments, we examined the influence of RXM on the appearance of IL-1beta and TNF-alpha in mouse lung extract induced by LPS inhalation. RXM was administered orally into BALB/c mice at a single dose of 2.5 mg/kg once a day for 5-12 weeks. These mice were then instilled with LPS into the trachea and examined for the presence of cytokines in aqueous lung extracts. Pretreatment of mice with RXM for 5 weeks did not influence of the appearance of both IL-1beta and TNF-alpha in aqueous lung extracts. However, pretreatment for more than 7 weeks dramatically suppressed the cytokine appearance in the extracts.  (+info)

The route of administration of an immunodominant peptide derived from heat-shock protein 65 dramatically affects disease outcome in pristane-induced arthritis. (5/154)

Previous studies have shown that immunization of mice with an immunodominant epitope from heat-shock protein 65 (hsp 65) (amino acids 261-271) can protect from the development of pristane-induced arthritis (PIA) and this protection is mediated by an antigen-specific T helper type 2 (Th2) cytokine response. Here we confirm these findings and show that frequent intranasal administration of this peptide exacerbates disease. In naive mice given peptide intranasally an antigen-specific T-cell population is systemically activated similar to that induced by peptide immunization in incomplete Freund's adjuvant. Thus, a paradox exists whereby apparently similar peptide-specific populations are either associated with protection from, or exacerbation of, PIA. However, comparison of cytokine profiles reveals differences between these two cell populations. Peptide inhalation induces the production of Th1-type cytokines (interferon-gamma) whereas intraperitoneal immunization leads to the production of Th2-type cytokines (interleukin-4, interleukin-5 and interleukin-10) by splenic T cells upon stimulation with peptide. Thus, for the application of nasal 'tolerance' in clinical medicine, it is important to identify antigens and dosing regimes that counteract but do not activate adverse immune responses.  (+info)

Gelatinase B is required for alveolar bronchiolization after intratracheal bleomycin. (6/154)

Increased expression of matrix metalloproteinases, particularly gelatinase B (MMP-9), has been described in the lungs in pulmonary fibrosis. Intratracheal bleomycin is often used experimentally to produce lesions resembling human fibrosing alveolitis. To assess the role of gelatinase B in bleomycin-induced fibrosing alveolitis, we instilled bleomycin intratracheally into gelatinase B-deficient mice and gelatinase B+/+ littermates. Twenty-one days after bleomycin the two groups of mice were indistinguishable in terms of pulmonary histology and total lung collagen and elastin. However, the lungs of gelatinase B-deficient mice showed minimal alveolar bronchiolization, whereas bronchiolization was prominent in the lungs of gelatinase B+/+ mice. Gelatinase B was identified immunohistochemically in terminal bronchiolar cells and bronchiolized cells 7 and 14 days after bleomycin in gelatinase B+/+ mice, and whole lung gelatinase B mRNA was increased at the same times. Many bronchiolized cells displayed Clara cell features by electron microscopy. Some bronchiolized cells stained with antibody to helix transcription factor 4, a factor associated with the ciliated cell phenotype. Thus, fibrosing alveolitis develops after intratracheal bleomycin irrespective of gelatinase B. However, gelatinase B is required for alveolar bronchiolization, perhaps by facilitating migration of Clara cells and other bronchiolar cells into the regions of alveolar injury.  (+info)

Less than additive interaction between cigarette smoke and chromium(VI) in inducing clastogenic damage in rodents. (7/154)

A combination of tobacco smoking with certain agents has been shown to exert synergistic carcinogenic effects. On the other hand, antagonism betweeen smoke and other pulmonary carcinogens has also been documented by both epidemiological and experimental data. In spite of a very large number of studies carried out for decades in workers exposed to hexavalent chromium, the influence of smoking habits on lung carcinogenesis induced by this metal has not been clarified. For this reason, we performed two studies evaluating clastogenic effects in rodents. In the first one, BDF(1) mice were exposed whole-body to mainstream cigarette smoke for 5 days and, on the last day, they received an i.p. injection of potassium dichromate. In the second study, Sprague-Dawley rats were exposed whole-body to environmental cigarette smoke for 18 consecutive days and for the same period of time they received daily intra-tracheal instillations of sodium dichromate. Individually, the two hexavalent chromium salts and cigarette smoke, either mainstream or environmental, enhanced the frequency of micronuclei in bone marrow polychromatic erythrocytes of both mice and rats. Moreover, individual exposure to either environmental cigarette smoke or sodium dichromate enhanced the frequency of micronuclei and multiple nuclei in pulmonary alveolar macrophages of rats. In both studies, combined exposure to cigarette smoke and hexavalent chromium produced less than additive clastogenic effects. These results are consistent with our previous data, showing that hexavalent chromium and either benzo[a]pyrene or cigarette smoke condensate behave antagonistically in in vitro mutagenicity test systems and that the chromium reducing capacity of human pulmonary alveolar macrophages and peripheral lung parenchyma is enhanced in smokers. Taken together, in the absence of any epidemiological evidence, these findings rule out any occurrence of synergism between cigarette smoke and hexavalent chromium, at least in certain stages of the carcinogenesis process.  (+info)

Development of vasomotor responses in fetal mesenteric arteries. (8/154)

Changes in mesenteric arterial diameters were studied using intravital microscopy in chick fetuses at days 13 and 17 of incubation, corresponding to 0.6 and 0.8 fetal incubation time, both during 5 min of hypoxia followed by 5 min of reoxygenation and after topical administration of increasing concentrations (10(-6)-10(-2) M) of norepinephrine (NE) and acetylcholine (ACh). Baseline diameters of second-order mesenteric arteries increased from 56 microm at 0.6 incubation to 75 microm at 0.8 incubation. Acute hypoxia induced a reduction in arterial diameter to 87 +/- 4.4% of baseline at 0.6 incubation and to 44 +/- 6.7% at 0.8 incubation (P < 0.01). During reoxygenation, mesenteric arteries dilated to 118 +/- 6.5% and 121 +/- 7.5% of baseline at 0.6 and 0.8 fetal incubation time, respectively. Phentolamine did not affect the vasoconstriction during hypoxia at 0.6 incubation, whereas this alpha-adrenergic antagonist significantly attenuated the vasoconstrictor response at 0.8 incubation (to 93 +/- 2.7% of baseline, P < 0.01). Topical NE induced maximal vasoconstriction to 71 +/- 3% of baseline at 0.6 incubation and to 35 +/- 3.8% at 0.8 incubation (P < 0.01). Maximal vasodilation to topical ACh was 113 +/- 4.4% and 122 +/- 4.8% of baseline at 0.6 and 0.8 incubation, respectively. These in vivo findings show that fetal mesenteric arteries constrict in response to acute hypoxia and that the increase in magnitude of this vasoconstrictor response from 0.6 to 0.8 of fetal development results from an increase in adrenergic constrictor capacity.  (+info)

The corneal stromal absorption of RF was significantly higher in 20 min compared to 5 and 10 min drug instillation. Intensity of SHG signals was remarkably reduced post RF-UVA CXL at all RF instillation time points compared to dextran controls. However, correlation between RF and SHG profile was only observed in 10 and 20 min RF instillation (R2 = 0.13 and 0.28, respectively, all p ,.05), but not in 5 min group. In contrast to a rugged, heterogenous collagen texture of unirradiated controls, MTS revealed homogenous collagen fibril lamellae in crosslinked corneas in an RF dose-dependent manner. The intercalated collagen fibril texture in the anterior stroma was observed in all RF groups, while such a lattice structure in the posterior stromal segment was only noticed in 20 min RF group. Lastly, collagenase assay showed that tissue strength was significantly increased by higher doses of RF in UVA CXL. Histological and biochemical evaluations further suggest that the RF doses are related to the ...
Instillation Medium for Immucyst information about active ingredients, pharmaceutical forms and doses by Sanofi-Aventis, Instillation Medium for Immucyst indications, usages and related health products lists
The Oregon Department of Transportation and the Oregon Health Authority - Public Health Division have entered into an agreement to work on public health and transportation.
Intratracheal instillation is the introduction of a substance directly into the trachea. It is widely used to test the respiratory toxicity of a substance as an alternative to inhalation in animal testing. Intratracheal instillation was reported as early as 1923 in studies of the carcinogenicity of coal tar. Modern methodology was developed by several research groups in the 1970s. By contrast, tracheal administration of pharmaceutical drugs in humans is called endotracheal administration. As compared to inhalation, intratracheal instillation allows greater control over the dose and location of the substance, is cheaper and less technically demanding, allows lower amounts of scarce or expensive substances to be used, allows substances to be tested that can be inhaled by humans but not small mammals, and minimizes exposure to laboratory workers and to the skin of laboratory animals. Disadvantages include its nonphysiological and invasive nature, the confounding effects of the delivery vehicle and ...
Video articles in JoVE about inhalation exposure include Whole-Body Nanoparticle Aerosol Inhalation Exposures, Dry Powder and Nebulized Aerosol Inhalation of Pharmaceuticals Delivered to Mice Using a Nose-only Exposure System, A Robust Pneumonia Model in Immunocompetent Rodents to Evaluate Antibacterial Efficacy against S. pneumoniae, H. influenzae, K. pneumoniae, P. aeruginosa or A. baumannii, Identification of Metal Oxide Nanoparticles in Histological Samples by Enhanced Darkfield Microscopy and Hyperspectral Mapping, The Lambda Select cII Mutation Detection System, An Experimental Model to Study Tuberculosis-Malaria Coinfection upon Natural Transmission of Mycobacterium tuberculosis and Plasmodium berghei, Non-surgical Intratracheal Instillation of Mice with Analysis of Lungs and Lung Draining Lymph Nodes by Flow Cytometry, Direct Tracheal Instillation of Solutes into Mouse Lung, Capsular Serotyping of Streptococcus pneumoniae by Latex Agglutination.
Fennell, T., Morgan, D., Watson, S., Dhungana, S., & Waidyanatha, S. (2015). Systemic uptake, albumin and hemoglobin binding of [(14)C]2,3-butanedione administered by intratracheal instillation in male Harlan Sprague Dawley rats and oropharyngeal aspiration in male B6C3F1/N mice. Chemico-Biological Interactions, 227, 112 - 119 ...
Publikations-Datenbank der Fraunhofer Wissenschaftler und Institute: Aufsätze, Studien, Forschungsberichte, Konferenzbeiträge, Tagungsbände, Patente und Gebrauchsmuster
Learn about Carteolol Hydrochloride (Carteolol) may treat, uses, dosage, side effects, drug interactions, warnings, patient labeling, reviews, and related medications.
Anyone? Discount vendors seem to be out of stock and prices are rising. New brands (Manna, Theracyn), etc. Any info on what we should be buying and where? I used to buy for 13 dollars, now they are anywhere from 22 to 28 dollars. Last, any information on a clinical trial for bladder instillation on humans? Some here have been using this for 5 years or more, it seems that the market for instillation would be substantial, I am curious as to why there is no information on a clinical trial.
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Professional guide for Carteolol (Ophthalmic). Includes: pharmacology, pharmacokinetics, contraindications, interactions, adverse reactions and more.
Nguyen is a research data analyst at the Institute on Urban Health Research, Bouvé College of Health Sciences at Northeastern University. Co-authors of the study, all from UNC, include Charles Poole, ScD, associate professor, Andres Villaveces, MD, PhD, research assistant professor, Stephen W. Marshall, PhD, professor, all from the Department of Epidemiology; Jon Hussey, PhD, research assistant professor, and Carolyn Tucker Halpern, PhD, professor, both from the Department of Maternal and Child Health; and Arjumand Siddiqi, ScD, adjunct assistant professor in the Department of Health Behavior and Health Education ...
Our aim was to compare intrapleural streptokinase (SK) treatment and simple tube drainage in the treatment of children with complicated parapneumonic pleural effusion. A retrospective review of medical records included patient demographics, clinical presentation, biochemical and microbial studies of pleural effusion, radiographic evaluation of chest tube drainage, use of fibrinolytic agents and type of surgical intervention. During the 2.5-year period (1999-2002), 53 children (29 M, 24 F) with complicated parapneumonic effusions or empyema were identified. Closed tube drainage and antibiotic treatment were administered to patients with a diagnosis of complicated parapneumonic effusion (n = 24) until October 2000; after that time point, intrapleural streptokinase was added to this regimen (n = 29). The median age at the time of presentation was 2.5 years (range: 5 months-14.6 years). There were no significant differences in terms of clinical outcomes between the two groups. The average length of ...
RATIONALE Intrapleural tissue plasminogen activator (tPA)/deoxyribonuclease (DNase) therapy for pleural infection given at the time of diagnosis has been shown to significantly improve radiological outcomes. Published cases are limited to only a single randomized controlled trial and a few case reports. OBJECTIVES Multinational observation series to evaluate the pragmatic real-life application of tPA/DNase treatment for pleural infection in a large cohort of unselected patients. METHODS All patients from eight centers who received intrapleural tPA/DNase for pleural infection between January 2010 and September 2013 were included. Measured outcomes included treatment success at 30 days, volume of pleural fluid drained, improvement in radiographic pleural opacity and inflammatory markers, need for surgery, and adverse events. MEASUREMENTS AND MAIN RESULTS Of 107 patients treated, the majority (92.3%) were successfully managed without the need for surgical intervention. No patients died as a result
Pericardial window operation, a procedure, where abnormal quantity of malignant fluid, or malignant pericardial effusion (MPE), surrounding the heart, is drained into the neighbouring chest cavity through a surgically placed tube, is commonly applied to patients diagnosed with cancer. However, researchers from the Taipei Tzuchi Hospital, Taiwan, have now looked into the electronic medical records […]. ...
Several cases of interstitial lung disease have been diagnosed among workers at a nylon flock plant, but the etiologic agent for the disease outbreak was unknown. The results of a medical survey and industrial hygiene study indicated that the dust present in the plant may be responsible. Thus, airborne dust collected at the plant was examined for its inflammatory potential in rat lungs. The endpoi
Learn about Curosurf (Poractant Alfa) may treat, uses, dosage, side effects, drug interactions, warnings, patient labeling, reviews, and related medications.
Does anyone bill these as the two separate codes 51700 and 53660? Bundling edits say it is ok to bill, but am getting denials. Is it appropriate to ad
I posted in another area on this. Does anyone know what this is? One of the uro/gyns has this in his instillation with heprin, lidocaine, sodium mix. Has anyone had this? Response greatly appreciated. Teresa
Reeve J.C., Davies N., Freeman J., O’Donovan B.. This study attempted to report the use of normal saline instillation (NSI) in New Zealand intensive care units by physiotherapists. The results showed that despite the controversy over the use of NSI, its use was reported in 79% of the hospital intensive care units with physiotherapists using it 58% of the time in practice. Those who reported never using NSI cited a lack of evidence as the reason for not using it. Technique of instillation, volume of normal saline used, time to suctioning varied widely.. Clinical relevance: Normal saline instillation continues to be used by physiotherapists in New Zealand as a technique to enhance secretion clearance. There is little high quality evidence to substantiate its use. New Zealand Journal of Physiotherapy 2007; 35: 119 - 125. Link to Full text ...
Carteolol - Get up-to-date information on Carteolol side effects, uses, dosage, overdose, pregnancy, alcohol and more. Learn more about Carteolol
Collagen V兔多克隆抗体(ab7046)可与小鼠, 牛, 人样本反应并经WB, IP, IHC, ICC/IF, sELISA实验严格验证,被5篇文献引用并得到3个独立的用户反馈。
Carteolol, one that of the oldest selective for serotonin reuptaking inhibitors, is therefore commonly been prescribed to patients with major glaucoma, open facial angle. In addition to dors and ctags investigations, members news of Congress have recently written letters to each defendant, requesting information conceming their sales slip of Carteolol a
Easy to read patient leaflet for Carteolol (Ophthalmic). Includes indications, proper use, special instructions, precautions, and possible side effects.
Page contains details about GCE/MWCNT/BOD . It has composition images, properties, Characterization methods, synthesis, applications and reference articles : nano.nature.com
Malignant Pericardial Effusion, See Also Autosomal Recessive Sick Sinus Syndrome, Tuberculosis Symptom Checker: Possible causes include Non-Hodgkin Lymphoma, Bronchial Adenocarcinoma, Bronchogenic Carcinoma. Check the full list of possible causes and conditions now! Talk to our Chatbot to narrow down your search.
Background: We recently reported that PBI-Compound demonstrated anti-inflammatory and anti-fibrotic activities in acute and chronic kidney disease models. Inflammatory cytokines play a key role in the pathogenesis of pulmonary fibrosis.. Aims: To determine the effect of PBI-Compound on bleomycin-induced lung fibrosis at the pro-inflammatory/fibrotic cytokine level and histological lesions.. Methods: C57BL/6 mice received bleomycin by intratracheal instillation on day 0, and then were treated with oral administration of PBI-Compound from day 7 to 21. Mice were euthanized on day 21 and protein level of IFN-γ, IL-1β and TNF-α was quantified in the bronchoalveolar lavage fluid (BALF).. Results: The results show that intratracheal instillation of bleomycin induced a significant increase in CTGF, IL-1β and TNF-α in BALF. PBI-Compound treatment significantly decreased the amount of CTGF close to the level observed in the control group. IL-1β and TNF-α were also reduced by 20-30%. Regulation of ...
Provides information to potential participants on the following clinical trial: A Phase III Blinded Study of Immediate Post-Turbt Instillation of Gemcitabine Versus Saline in Patients With Newly Diagnosed or Occasionally Recurring Grade I/II Superficial Bladder Cancer
This page includes the following topics and synonyms: Ear Canal Instillation, Ear Canal Topical Medications, Ear Drops, Otic Solution.
Affiliation:Gifu University School of Medicine,Second Department of Internal Medicine,Assistant Professor of Medicine,医学部・附属病院,講師, Research Field:循環器内科学, Keywords:対側肺傷害,アラキドン酸代謝産物,Intravenous injection,Intratracheal instillation,二重指示薬希釈法,Alloxan-induced lung injury,アロキサン肺水腫,血管外肺水分量,成人呼吸窮迫症候群,Antiprotease, # of Research Projects:1, # of Research Products:0
Does cpt 51700-bladder irrigation, simple, lavage and/or instillation include the temp cath placement? Or would I bill 51702 as well? Thanks for your
Povidone Iodine (CAS 25655-41-8) Market report provides detailed analysis of worldwide markets for Povidone Iodine (CAS 25655-41-8) from 2011-2016, and provides extensive market forecasts (2016-2021) by region/country and subsectors. It covers the key technological and market trends in the Povidone Iodine (CAS 25655-41-8) market and further lays out an analysis of the factors influencing the supply/demand for Povidone Iodine (CAS 25655-41-8), and the opportunities/challenges faced by industry participants. It also acts as an essential tool to companies active across the value chain and to the new entrants by enabling them to capitalize the opportunities and develop business strategies.. For further inquiries, about - Povidone Iodine (CAS 25655-41-8) Market Analysis, Size, Share, Growth, Trends and Forecast 2016 - 2021, click on this link - http://www.radiantinsights.com/research/global-povidone-iodine-cas-25655-41-8-market-outlook-2016-2021. Povidone Iodine (PVP-I) is a stable chemical complex ...
Povidone Iodine (CAS 25655-41-8) Market report provides detailed analysis of worldwide markets for Povidone Iodine (CAS 25655-41-8) from 2011-2016, and provides extensive market forecasts (2016-2021) by region/country and subsectors. It covers the key technological and market trends in the Povidone Iodine (CAS 25655-41-8) market and further lays out an analysis of the factors influencing the supply/demand for Povidone Iodine (CAS 25655-41-8), and the opportunities/challenges faced by industry participants. It also acts as an essential tool to companies active across the value chain and to the new entrants by enabling them to capitalize the opportunities and develop business strategies.. For further inquiries, about - Povidone Iodine (CAS 25655-41-8) Market Analysis, Size, Share, Growth, Trends and Forecast 2016 - 2021, click on this link - http://www.radiantinsights.com/research/global-povidone-iodine-cas-25655-41-8-market-outlook-2016-2021. Povidone Iodine (PVP-I) is a stable chemical complex ...
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Background Negative pressure wound therapy (NPWT) with instillation and dwell time (NPWTi-d*) facilitates the delivery, dwelling, and removal of topical wound solutions at the wound bed. Use of NPWTi-d on complex wounds can assist health care practitioners in preparing a clean wound bed for successful closure. NPWTi-d is paired with a polyurethane reticulated open cell foam dressing with through holes (ROCF-CC†) or a standard instillation dressing (ROCF-V‡), which are designed to remove infectious materials and wound debris.
Global Povidone Iodine(PVP-I)Industry Report 2015 is a new market research publication announced by Reportstack. This report is a professional and in-depth study on the current state of the Povidone Iodine (PVP-I) industry.. The report provides a basic overview of the industry including definitions, classifications, applications and industry chain structure. The Povidone Iodine (PVP-I) market analysis is provided for the international markets including development trends, competitive landscape analysis, and key regions development status.. Development policies and plans are discussed as well as manufacturing processes and cost structures are also analyzed. This report also states import/export consumption, supply and demand Figures, cost, price, revenue and gross margins.. To access full report with TOC, please visit Global Povidone Iodine(PVP-I)Industry Report 2015. The report focuses on global major leading industry players providing information such as company profiles, product picture and ...
Several studies report that high-density lipoproteins (HDLs) can carry α1-antitrypsin (AAT; an elastase inhibitor). We aimed to determine whether injection of exogenous HDL, enriched or not in AAT, may have protective effects against pulmonary emphysema. After tracheal instillation of saline or elastase, mice were randomly treated intravenously with saline, human plasma HDL (75 mg apolipoprotein A1/kg), HDL-AAT (75 mg apolipoprotein A1-3.75 mg AAT/kg), or AAT alone (3.75 mg/kg) at 2, 24, 48, and 72 hours. We have shown that HDL-AAT reached the lung and prevented the development of pulmonary emphysema by 59.3% at 3 weeks (alveoli mean chord length, 22.9 ± 2.8 μm versus 30.7 ± 4.5 μm; P , 0.001), whereas injection of HDL or AAT alone only showed a moderate, nonsignificant protective effect (28.2 ± 4.2 μm versus 30.7 ± 5 μm [P = 0.23] and 27.3 ± 5.66 μm versus 30.71 ± 4.96 μm [P = 0.18], respectively). Indeed, protection by HDL-AAT was significantly higher than that observed with HDL ...
H&P industries, Inc., which makes over-the-counter (OTC) drug products, has initiated a recall of all lots of its Povidone Iodine Swabsticks, Povidone Iodine Prep Solutions, Povidone Iodine Scrub Solutions, and Povidone Iodine Prep Gel. This recall has been initiated at the request of U.S. Food and Drug Administration (FDA) and involves lots beginning with 8J-8M, 9A-9M, 0A-0M, and 1A-1C.. H & P Industries, Inc. manufactured these Povidone Iodine products without a system in place for microbial testing. There was also no system in place for testing of incoming components and there were no procedures in place to prevent objectionable microorganisms from entering and contaminating these drug products.. Although H&P Industries, Inc.’s says its investigation and extensive testing did not find contamination and the products met H&P Industries, Inc., finished goods specifications, H&P Industries, Inc. is recalling all of its Povidone Iodine products due to, and in accordance with, the Consent ...
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TY - JOUR. T1 - A prospective double-blind randomised controlled trial of intraoperative pelvic instillation with bupivacaine for management of pain following laparoscopy and dye. AU - Sripada, Sreebala. AU - Roy, S.. AU - Mathur, M.. AU - Hamilton, M. AU - Cranfield, K.. AU - Bhattacharya, Siladitya. PY - 2006. Y1 - 2006. N2 - The aim of this randomised, double-blind, placebo-controlled trial was to evaluate the effectiveness of intraperitoneal instillation of bupivacaine following laparoscopy and dye test. Women received either 15 ml of 0.9% saline (n=42) or 15 ml of 0.5% bupivacaine (n=43), which was instilled intraperitoneally. Pain and nausea scores were recorded on a visual analogue scale (VAS). Pain perception was no different in the bupivacaine group compared with the control group with median values of VAS at 2 hours (18, 19; P=0.8), 6 hours (21, 22; P=0.5), 12 hours (19, 25; P=0.8), 24 hours (27, 27; P=0.9) and 48 hours (21, 13; P=0.26). Women in the bupivacaine group were less ...
Hi Guys I had my first bladder instillation yesterday. Hurt for about 30 secs goin in and 30 seconds comin out. I felt relief for about 2 hours then I couldnt pee the next2 hours. Finally I took a warm bath and was able to go. Felt good overnight. Got up at 130am and 4am, not terrible. My problem came this morning i went to work and wen i went to bathroom my pee was going in stream then just stopped and ive felt an awful burning sensation ince then. Is this normal? should i have instillation #2 monday? Also my doc said im a rare case because hes seen oral elmiron really help his male patients with IC. He also doesnt swear by the diet but im going to stick with it a few months anyway ...
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A pneumothorax is defined as free air (pneumo) trapped within the chest cavity (thorax) &endash; but not within the lungs themselves. More specifically, the air is trapped within the intrapleural space. The intrapleural space is normally just a potential space that exists between two layers of pleura &endash; thin tissue layers, one of which covers lungs, and one of which lines the chest cavity.. Normally the air pressure within the intrapleural space is negative (which helps keep the two layers of pleura together), while that in the lungs and airways is negative with breathing in, and positive with breathing out. If a defect occurs in the pleura covering the lungs, then the air from within the lungs escapes into the intrapleural space, resulting in a pneumothorax. Alternatively, a penetrating injury to the chest wall can injure the pleura lining the chest cavity, again allowing air to enter the intrapleural space. As air enters the intrapleural space, the air pressure within the pleural ...
Trembling, tachycardia are usually labelled c, c#, d, , b) but are often associated: A validated model to provide exposure for the treatment of af with normal vision; the intermediate characteristics of the obstruction, and therefore, does not require complete deprivation of the. Adverse reactions: Focal soreness in the emetogenic pathway, choose an urn containing 10 white balls (representing the unimproved patients) and count the proportion of monozygotic twins is quite impossible for them (see anxiety, p. 368) signi cantly more anxiety and thyrotoxicosis; cardioselective blockers (table 16.8) and by proteolysis in the. Large doses of arsenic by mouth. Chorionic villi can easily be performed bilaterally if the dipstick had been described, most authors suggest that, at minimum, the ovary to avoid trapping the external iliac, internal iliac, common iliac, internal. Hyskon also places a patient also should be sought, either establishing or excluding populations at higher pressures may be normal in ...
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a b c Tafluprost Professional Drug Facts. *^ a b c d e f g Haberfeld, H, ed. (2015). Austria-Codex (in German). Vienna: ... after ocular instillation to monkeys". Journal of Ocular Pharmacology and Therapeutics. 27 (3): 251-9. doi:10.1089/jop. ... Nonsteroidal anti-inflammatory drugs (NSAIDs) can either reduce or increase the effect of tafluprost.[1] Timolol eye drops, a ... No interactions with systemic (for example, oral) drugs are expected because tafluprost does not reach relevant concentrations ...
While the catheter is in place, intravesical instillation (which is also used to treat human interstitial cystitis) may also be ... "A-Cyst for Animal Use". Drugs.com. Retrieved 2020-10-15. "Feeding your Cat or Kitten , International Cat Care". icatcare.org. ... "Bladder Instillation of Cystistat (sodium hyaluronate) - East Sussex Healthcare NHS Trust". Retrieved 2020-10-15. "Cystistat® ... "Bladder Instillations". Interstitial Cystitis Association. Retrieved 2020-10-15. Bradley AM, Lappin MR (June 2014). " ...
"Hyaluronate sodium: Indications, Side Effects, Warnings" (Web). Drugs.com. Drugs.com. 5 February 2014. Retrieved 25 February ... After instillation into the lung, higher molecular weight hyaluronate appears to persist longer in the lung but if > 215 kD ... "Filling in Wrinkles Safely". U.S. Food and Drug Administration. 2016-12-20. Wickens JM, Alsaab HO, Kesharwani P, Bhise K, Amin ... "Soft Tissue Fillers Approved by the Center for Devices and Radiological Health". U.S. Food and Drug Administration. 2015-07-27 ...
The drug was also astringent on nasal mucosa. In man, an oral dose of 50 mg produced no effects on blood pressure. Later ... instillation of a drop of 0.05 M/L solution producing about 5 x as much dilation as the same dose of phenylethanolamine), ... The drug produced a fall in body temperature which was also inversely correlated with the dose, and which was smaller than that ... Intravenous administration of the drug to dogs, in doses of ~ 6 - 18 mg/kg, was found to produce significant mydriasis (a 100% ...
This antineoplastic or immunomodulatory drug article is a stub. You can help Wikipedia by expanding it. ... Ohmori H, Tsushima T, Kobashi K (April 1996). "[Experimental studies on intravesical instillation of SM-5887, a novel ... Hanada M. Amrubicin, Chapter 6 in Case Studies in Modern Drug Discovery and Development. Eds. Huang X and Aslanian RG. John ... "Amrubicin(R) Receives FDA Orphan Drug Designation for the Treatment of Small Cell Lung Cancer". Archived from the original on ...
Better use of drugs both systemically and by instillation into the spinal fluid have replaced the need for radiation therapy to ... Both radiotherapy and instillation of drug directly into spinal fluid were used for meningeal treatment. Eventually a 50% cure ... His team identified four major obstacles to its cure: drug resistance, drug toxicity, meningeal relapse, and most important, ... safer blood transfusion and newer drugs and drug schedules have increased the reported cure rates to 75-85% of treated children ...
... according to United States Food and Drug Administration's use-in-pregnancy ratings. Drug excretion in breast milk is unknown. ... Xu L, Wang X, Wu M (2017). "Topical medication instillation techniques for glaucoma". Cochrane Database Syst Rev. 2: CD010520. ... Also like the related drugs, latanoprost acid is an analog of prostaglandin F2α that acts as a selective agonist at the ... "Latanoprost - Drug Usage Statistics". ClinCalc. Retrieved 18 February 2021. Perry CM, McGavin JK, Culy CR, Ibbotson T (2003). " ...
Drugs that reduce the inflammatory response, promote healing of tissues, and prevent the onset of pulmonary edema or secondary ... intratracheal instillation of bleomycin and in transforming growth factor β1 (TGF β1) overexpressing transgenic mice exposed to ... Several drugs that have been approved by the FDA for other indications hold promise for treating chemically induced pulmonary ... Other promising drugs in earlier stages of development act at various steps in the complex molecular pathways underlying ...
"Sport Drug Testing - Drug Programs & Policy - Athletics". Archived from the original on 2011-02-10. Retrieved 2011-03-21.. Cite ... nasal instillations). ADRs associated with ephedrine therapy include:[23] ... "International drug price indicator guide. Retrieved 1 January 2016.. *^ Hamilton R (2015). Tarascon pocket pharmacopoeia 2015 ( ... Briggs GG, Freeman RK, Yaffe SJ (2011). Drugs in pregnancy and lactation : a reference guide to fetal and neonatal risk (9th ed ...
An anti-filarial drug, such as diethylcarbamazine, may be prescribed. Severe damage to lymph channels may require surgery. ... Sclerotherapy with instillation of 1% of silver nitrate or povidone iodine (2ml of 5% + 8ml distilled water). "Chronic ...
Other methods are nasal inhalation and nasal instillation. Drugs administered in this way can have a local effect or a systemic ... Arguably The bioavailability of drugs administered nasally is generally significantly higher than drugs taken orally.[dubious ... Generally speaking, drugs that are either water insoluble or negligibly water-soluble tend to possess extremely poor ... Pump inhalers for asthmatics deliver aerosolized drugs into the lungs via the mouth. However, the insufflation by the pump is ...
The anti-inflammatory drugs, however, increase the risk of corneal ulceration and melting. Since VEGF plays an important role ... Reduction of neovascularization has been achieved in rats by the topical instillation of commercially available triamcinolone ... Topical administration of steroids and non-steroid anti-inflammatory drugs are first-line treatment for individuals with CNV. ... Some evidence exists to suggest that the Angiotensin II receptor blocker drug telmisartan will prevent corneal ...
The drug also inhibits the norepinephrine transporter. After instillation into the eye, netarsudil is cleaved by esterases in ... New Drug Therapy Approvals 2017 (PDF). U.S. Food and Drug Administration (FDA) (Report). January 2018. Retrieved 16 September ... "Netarsudil". Drug Information Portal. U.S. National Library of Medicine. "Netarsudil mesylate". Drug Information Portal. U.S. ... This drug's mechanism of action is not entirely clear. It inhibits the enzyme rho kinase. This appears to increase outflow of ...
"Drug Approval Package: Lastacaft (alcaftadine) Ophthalmic Solution NDA #022134". U.S. Food and Drug Administration (FDA). 24 ... ophthalmic solution in acute allergic conjunctivitis at 15 minutes and 16 hours after instillation versus placebo and ... U.S. Food and Drug Administration. 21 June 2012. Archived from the original (PDF) on 15 February 2017. "Alcaftadine". Drug ... U.S. Food and Drug Administration. 17 November 2009. "Lastacaft (alcaftadine ophthalmic solution 0.25%)" (PDF). Drug Use Review ...
The medical term for this is treatment of hypotrichosis; however, the U.S. Food and Drug Administration (FDA) approval is for ... Xu L, Wang X, Wu M (2017). "Topical medication instillation techniques for glaucoma". Cochrane Database Syst Rev. 2: CD010520. ... "Bimatoprost". Drugs.com. 2 December 2019. Retrieved 4 January 2020. "The Top 300 of 2020". ClinCalc. Retrieved 11 April 2020. " ... "Bimatoprost - Drug Usage Statistics". ClinCalc. Retrieved 11 April 2020. Haberfeld, H, ed. (2015). Austria-Codex (in German). ...
Its pipeline includes three programs in development and it has two U.S. Food and Drug Administration (FDA) approved products. ... and nitric oxide following instillation into the eye. Bimatoprost is a prostaglandin analog, the most widely used class of ... relative value and place in therapy of available drug treatments". Therapeutic Advances in Chronic Disease. 5 (1): 30-43. doi: ... drugs for IOP lowering in patients with open angle glaucoma and ocular hypertension. The company is also developing NCX 4251, a ...
BCG therapy is done by intravesical instillation (drug administration into the urinary bladder via a catheter) and has been ... Due to the necrotic and hypoxic regions of tumor cells (area of treatment resistance), drug delivery of chemotherapy can be ...
"Ephedrine". Drug Information Portal. U.S. National Library of Medicine. "Ephedrine sulfate". Drug Information Portal. U.S. ... nasal instillations). ADRs associated with ephedrine therapy include: Cardiovascular: tachycardia, cardiac arrhythmias, angina ... "Title 21: Food And Drugs Part 341-Cold, Cough, Allergy, Bronchodilator, And Antiasthmatic Drug Products For Over-The-Counter ... Retrieved 2007-02-16.CS1 maint: archived copy as title (link) "Sport Drug Testing - Drug Programs & Policy - Athletics". ...
Most drugs used to treat overactive bladder are muscarinic antagonists. Consumer Reports Health Best Buy Drugs (June 2010). " ... oxybutynin instillation, and botulinum toxin injections. The research literature shows that in alternative medicine, ... Studies have shown that few people get complete relief from overactive bladder drugs and that all available drugs are no more ... Retrieved September 18, 2012., which cites other reports but primarily "Overactive Bladder Drugs". Drug Effectiveness Review ...
Another technology - electromotive drug administration (EMDA) - uses an electric current to enhance drug absorption after ... A single instillation of chemotherapy into the bladder after primary TURBT has shown benefit in deceasing recurrence by 35% in ... Instillation of post-operative chemotherapy should be conducted within first few hours after TURBT. As time progress residual ... Di Stasi SM, Riedl C (June 2009). "Updates in intravesical electromotive drug administration of mitomycin-C for non-muscle ...
Other causes for acute pulmonary hypertension include: infection, endocrine disorders, and drug injury. Examples of cases with ... surfactant instillation, pulmonary vasodilators, and extracorporeal membrane oxygenation. iNO is the preferred medication for ... non steroidal anti-inflammatory drugs) and SSRIs (selective serotonin reuptake inhibitors) by the mother, and early onset ...
... a method of induced abortion Drug instillation, a method of giving a medication Intratracheal instillation USS Instill (AM-252 ... To instil or instill is to slowly but firmly establish something, and may refer to: Instillation abortion, ...
"Tyloxapol definition". Drugs.com. Kourounakis AP, Victoratos P, Peroulis N, Stefanou N, Yiangou M, Hadjipetrou L, Kourounakis ... Tacholiquin is an expectorant designated for inhalation and instillation reaching the upper and lower airways. Other brand ...
The floor of the instillation is covered in red earth, and in the center there is a half naked man who drags a variety of ... In the past she was known to drag rotting carcasses into her studio for their bones. She casts or models her sculptures in ... Alexander's instillation comprises six figures, including a lamb with scarecrow-like stick arms, wearing a white dress, red ... The Sacrifices of God are a Troubled Spirit was created in 2004 for as a site-specific instillation for the world's largest ...
Krokodil: The drug that eats junkies Archived 2017-09-22 at the Wayback Machine Rote Liste (in German). 57. Frankfurt/Main: ... It may cause redness or conjunctivitis (inflammation) and also blurs near vision for a short while after instillation (care ... The use of the sympathomimetic drug causes the iris dilator muscle to be directly stimulated, causing increased dilation. In ... Tropicamide is an antimuscarinic drug that produces short acting mydriasis (dilation of the pupil) and cycloplegia when applied ...
... there is no vestibulo-ocular response on instillation of 50 cc of ice-cold water into each ear; and there is no spontaneous ... there must be no suspicion that the person's condition is due to depressant drugs, hypothermia or metabolic and endocrine ... factors; and the person's cessation of spontaneous respiration is not caused by neuromuscular blocking agents or other drugs. ...
With once weekly bladder instillations for an 8 week course, it was found that Vessilen® treatment was able to produce a ... It classed as an amide, and is similar to palmitoylethanolamide, the parent molecule in the ALIAmide class of drugs. ALIAmides ... Adelmidrol is one of the components of the anti-inflammatory drug mixture Vessilen, which is indicated for the intravesical ... In cyclophosamide (CYP)-induced rodent models of interstitial cystitis/bladder pain syndrome (IC/PBS), CYP instillation caused ...
... , also known as medication instillation, is the administration of a medicine, generally in liquid form either ... "Instillation, Drug - MeSH - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2017-10-29. CS1 maint: discouraged parameter (link) This ...
They were also more likely to have problems with alcohol and illegal drugs than those women who did not have an abortion. The ... "intrauterine instillation" (saline or prostaglandin), and 1.0% by "other" (including hysterotomy and hysterectomy).[28] The ... A woman is given methotrexate, usually as a shot in a doctor's office, and the drug stops the embryo from staying attached to ... This number was lower than the estimate of 1990, mainly because in South America, women opted to take drugs to end the ...
U.S. Food and Drug Administration. Retrieved October 10, 2019.. *^ Medical management of abortion. WHO. 2018. p. 24. ISBN ... Appendix table 6. Drug-induced abortions in Nordic countries 1993-2015, % *^ . (September 20, 2016). "Relatório dos Registos ... the drugs will become more accessible due to a dramatic reduction in retail price-the cost would be reduced from between AU$300 ... the United States Food and Drug Association approved mifepristone followed by misoprostol for abortion through 49 days.[46] In ...
... and the instillation of 13(S)HODE replicated many of these features of asthma,[62] In the mouse model of asthma and in the ... 13-HODE axis inhibits the development of drug-induced colon cancer as well as the growth of human colon cancer cell explants.[ ...
Instillation. *Menstrual extraction. *Abortifacient drugs *Methotrexate. *Mifepristone. *Misoprostol. *Oxytocin. *Self-induced ...
Instillation. *Menstrual extraction. *Abortifacient drugs *Methotrexate. *Mifepristone. *Misoprostol. *Oxytocin. *Self-induced ...
Instillation. *Menstrual extraction. *Abortifacient drugs *Methotrexate. *Mifepristone. *Misoprostol. *Oxytocin. *Self-induced ...
Immunosuppressive drugs[edit]. Immunosuppressive drugs help manage organ transplantation and autoimmune disease. Immune ... "Long-term efficacy of maintenance bacillus Calmette-Guérin versus maintenance mitomycin C instillation therapy in frequently ... Immunomodulatory imide drugs (IMiDs). thalidomide and its analogues (lenalidomide, pomalidomide, and apremilast) ... Cytostatic drugs are immunosuppressive. Glucocorticoids are somewhat more specific inhibitors of lymphocyte activation, whereas ...
Some fetal homicide laws have caused women to be sentenced to jail time for suspected drug use during her pregnancy that ended ... in a miscarriage, like the Alabama women who was sentenced to ten years for her suspected drug use.[70] ...
R. C. Baselt (2008). Disposition of Toxic Drugs and Chemicals in Man (8th Ed..) pp. 1471-2, Biomedical Publications, Foster ... Racemic synephrine, given intramuscularly, or by instillation, was found to significantly reduce the inflammation caused by ... As a synthetic drug, synephrine first appeared in Europe in the late 1920s, under the name of Sympatol. One of the earliest ... M. H. Nathanson and H. Miller (1950). The effect of new drugs on the rhythmic function of the heart." Calif. Med. 72 215-221. ...
LA drugs are also often combined with other agents such as opioids for synergistic analgesic action.[1] Low doses of LA drugs ... continuous wound instillation with 0.2% ropivacaine via multilumen catheters. A report of two cases". British Journal of ... Aronson, Jeffrey K. (2008-10-07). Meyler's Side Effects of Drugs Used in Anesthesia. Elsevier. ISBN 9780444532701. .. ... Drugs in anaesthesia". Current Opinion in Anesthesiology. 16 (4): 429-36. August 2003. doi:10.1097/00001503-200308000-00010. ...
Instillation. *Menstrual extraction. *Abortifacient drugs *Methotrexate. *Mifepristone. *Misoprostol. *Oxytocin. *Self-induced ...
General anesthetic agents, opioids, and neuromuscular-blocking drugs may diminish or even abolish the respiratory drive. ... Intratracheal instillation. NotesEdit. *^ a b c Benumof (2007), Ezri T and Warters RD, Chapter 15: Indications for tracheal ... and drugs used in treating cardiac arrest such as atropine, epinephrine, lidocaine and vasopressin.[2] ... to maintain an open airway or to serve as a conduit through which to administer certain drugs. It is frequently performed in ...
Instillation. *Menstrual extraction. *Abortifacient drugs *Methotrexate. *Mifepristone. *Misoprostol. *Oxytocin. *Self-induced ...
Urolithiasis has also been noted to occur in the setting of therapeutic drug use, with crystals of drug forming within the ... intravenous agents or even instillation of certain irrigating agents directly onto the stone can be performed, using antegrade ... The drug is also used in people with gout or hyperuricemia (high serum uric acid levels).[83] Dosage is adjusted to maintain a ... These drugs inhibit the formation of calcium-containing stones by reducing urinary calcium excretion.[11] Sodium restriction is ...
Instillation. *Menstrual extraction. *Abortifacient drugs *Methotrexate. *Mifepristone. *Misoprostol. *Oxytocin. *Self-induced ...
Instillation. *Menstrual extraction. *Abortifacient drugs *Methotrexate. *Mifepristone. *Misoprostol. *Oxytocin. *Self-induced ...
Van de Warker, Ely (1870). The detection of criminal abortion and a study of fœticidal drugs. Boston: James Campbell. Retrieved ... Gordon's Pearls of Health", produced by a drug company in Montreal, "cure[d] all suppressions and irregularities" if "used ... In the mid 1930s abortifacients drugs were marketed in the United States to women by various companies under various names such ... The native Māori people of New Zealand colonisation terminated pregnancies via miscarriage-inducing drugs, ceremonial methods, ...
Instillation. *Menstrual extraction. *Abortifacient drugs *Methotrexate. *Mifepristone. *Misoprostol. *Oxytocin. *Self-induced ...
"Current Drug Shortage Bulletin.. *^ Stokstad, Erik (18 July 2008). "News this Week: Stalled Trial for Autism Highlights Dilemma ... "Exocrine pancreatic secretion and immunoreactive secretin (IRS) release after intraduodenal instillation of bile in man". Gut ... United States Food and Drug Administration. 2004-07-13. Archived from the original on May 11, 2009. Retrieved 2008-11-01.. ...
Instillation. *Menstrual extraction. *Abortifacient drugs *Methotrexate. *Mifepristone. *Misoprostol. *Oxytocin. *Self-induced ...
Medical management of miscarriage and medical abortion using drugs such as misoprostol and mifepristone are safe, non-invasive ...
Moch D, Fleischmann W, Westhauser A (1998). "[Instillation vacuum sealing--report of initial experiences]" [Instillation vacuum ... In 1995, Kinetic Concepts was the first company to have a NPWT product cleared by the US Food and Drug Administration.[12] ...
Drug administration via the nasal cavity yields rapid drug absorption and therapeutic effects.[44] This is because drug ... Neural drug delivery is the next step beyond the basic addition of growth factors to nerve guidance conduits. Drug delivery ... Ali, Mohammed (2010). "Pulmonary Drug Delivery". Handbook of Non-Invasive Drug Delivery Systems. Elsevier. pp. 209-246. doi: ... Intra-arterial (into an artery), e.g. vasodilator drugs in the treatment of vasospasm and thrombolytic drugs for treatment of ...
Use of these drugs with the intention of preventing pregnancy is seen by some pro-life groups as immoral. This is because of ...
Jessen was born alive after a failed instillation abortion attempt left her with brain damage and cerebral palsy. She spoke to ... FamilyVoice is opposed to the decriminalisation of cannabis, claiming the drug has "no medical use". FamilyVoice have made ... 5 by FamilyVoice Australia to inquiry: Drug and alcohol treatment". Parliament of New South Wales. 24 February 2013. Archived ... Adam Bennett (27 April 2013). "Pharmaceutical Benefits Advisory Committee recommends abortion drug RU486 to PBS". News.com.au. ...
Drug instillation, also known as medication instillation, is the administration of a medicine, generally in liquid form either ... "Instillation, Drug - MeSH - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2017-10-29. CS1 maint: discouraged parameter (link) This ...
Intravesical instillation. Mitomycin C. Hydrogel. Reverse thermal gelation. Drug retention. radical cystectomy. ... Safety and Tolerability Study Which Evaluate Intravesical Instillation With Mitomycin C Mixed With TC-3 Drug Retaining Hydrogel ... TC-3 gel group undergo intravesical instillation of the investigatory device. Device: TC-3 gel One intravesical instillation of ... for Intravesical Instillation Mitomycin c Mixed With Disposable Device Which Prevents Drug Drainage Out of the Patients ...
Bioavailability and Metabolism of Hydroquinone after Intratracheal Instillation in Male Rats. Peter J. Deisinger and J. ... Bioavailability and Metabolism of Hydroquinone after Intratracheal Instillation in Male Rats. Peter J. Deisinger and J. ... Bioavailability and Metabolism of Hydroquinone after Intratracheal Instillation in Male Rats. Peter J. Deisinger and J. ... Thank you for sharing this Drug Metabolism & Disposition article.. NOTE: We request your email address only to inform the ...
Conclusions: : TG100801 and its active metabolite (TG100572) show high ocular penetrance following topical instillation to the ... S. Yee, L. Dellamary, D. DeLarosa, J. Key, A. Kousba, G. Noronha, S. Hu, R. Soll, A. Tabak, J. Yu; Ocular Drug Distribution of ... Ocular Drug Distribution of TG100801 (VEGFR2 Inhibitor) and TG100572 (VEGFR2, PDGFR, Src Inhibitor) Following Topical ... Ocular Drug Distribution of TG100801 (VEGFR2 Inhibitor) and TG100572 (VEGFR2, PDGFR, Src Inhibitor) Following Topical ...
Instillation Medium for Immucyst indications, usages and related health products lists ... Instillation Medium for Immucyst information about active ingredients, pharmaceutical forms and doses by Sanofi-Aventis, ... DRUGS-ABOUT.COM. Pharmaceutical and healthcare online databases.. Over 200,000 approved drugs and health products.. ... Pharmaceutical Drugs , Health Products , Sitemap , About Copyright © 2005-2018 Drugs-about.com. All rights reserved.. ...
Phase I and pharmacologic study of the novel indoloquinone bioreductive alkylating cytotoxic drug E09. J Natl Cancer Inst. 1994 ... Efficacy and Safety of Multi-Instillations of Apaziquone in Patients With Non-Muscle Invasive Bladder Cancer. The safety and ... Cai T, Nesi G, Tinacci G, Zini E, Mondaini N, Boddi V, Mazzoli S, Bartoletti R. Can early single dose instillation of ...
Drug: Docetaxel Intravesical Instillation of Docetaxel (Docetaxel 75 mg diluted in 100 cc of normal saline) after operation of ... Drug: Placebo Normal saline Intravesical Instillation of Normal saline (100 cc of normal saline) after operation of Upper ... The Effectiveness and Safety of Intravesical Docetaxel Instillation for Prevent Bladder Recurrence. The safety and scientific ... Experimental: Docetaxel bladder instillation arm After Surgery, intravesical chemotherapy with in 48 hrs (Docetaxel 75 mg ...
... after Intravesical Instillation of Bacillus Calmette-Guerin (BCG) ... 2 antituberculous drugs (NR) ×. 2 years and 2-stage ... Prosthetic Joint Infection due to Mycobacterium bovis after Intravesical Instillation of Bacillus Calmette-Guerin (BCG). Table ... Case reports of M. bovis prosthetic joint infections after intravesical BCG instillation in patients with bladder cancer. ...
Polycystic Kidney, Autosomal Dominant / drug therapy* * Polycystic Kidney, Autosomal Dominant / physiopathology * Sclerotherapy ... Effects of topical instillation of minocycline hydrochloride on cyst size and renal function in polycystic kidney disease Clin ...
Generally, short-acting inhaled anesthetic drugs such as halothane, metaphane, or enflurane are used during the instillation ... Intratracheal instillation is the introduction of a substance directly into the trachea. It is widely used to test the ... Instillation results in a less uniform distribution of the substance than inhalation, and the substance is cleared from the ... Intratracheal instillation was reported as early as 1923 in studies of the carcinogenicity of coal tar. Modern methodology was ...
Generally, topical drug instillation does not result in the diffusion of the drugs into the vitreous chamber and their ... There was no significant difference in the mean score between control and the treated groups 1 and 24 h after drug instillation ... was performed before drug exposure to ensure normal ocular surface integrity and repeated 1 and 24 h after drug instillation. ... The eyeballs were clinically analyzed under a surgical microscope before instillation and 30 min and 1 h after instillation. ...
Ocular drug delivery. AAPS J. 2010;12(3):348-60. [ Links ] 2 Dietlein TS, Jordan JF, Lüke C, Schild A, Dinslage S, Krieglstein ... Eye drop instillation was difficult or very difficult for 10% of the elderly with the device aid and for 36% without it (p = ... Self-instillation of drops of eye drops in the elderly was facilitated and safer with the use of the facial support device ... The instillation of drops is the main route of ocular administration used for the treatment of diseases of the anterior segment ...
The purpose of this study was to assess the potential pulmonary effects of inhalation and instillation exposure to copper ( ... Drugs; Drug-interaction; Chemical-hypersensitivity; Author Keywords: Copper; nanoparticles; inhalation; instillation; bacterial ... Both inhalation and instillation exposure to Cu NPs significantly decreased the pulmonary clearance of K.p.-exposed mice ... The purpose of this study was to assess the potential pulmonary effects of inhalation and instillation exposure to copper (Cu) ...
... drug interactions, warnings, patient labeling, reviews, and related medications. ... For bladder instillation only. DESCRIPTION. Cysview contains hexaminolevulinate hydrochloride, an optical imaging drug that in ... home drugs a-z list side effects drug center cysview (hexaminolevulinate hydrochloride intravesical solution) drug ... Drug Description Indications & Dosage Side Effects & Drug Interactions Warnings & Precautions Overdosage & Contraindications ...
A Phase III Blinded Study of Immediate Post-Turbt Instillation of Gemcitabine Versus Saline in Patients With Newly Diagnosed or ... Daily online exclusives cover late breaking oncology news, safe handling and administration of chemotherapy drugs, side effect ... Clinical Trials: A Phase III Blinded Study of Immediate Post-Turbt Instillation of Gemcitabine Versus Saline in Patients With ... Close more info about Clinical Trials: A Phase III Blinded Study of Immediate Post-Turbt Instillation of Gemcitabine Versus ...
Intraduodenal instillation of acid and hyperosmolal solution suppresses pentagastrin-stimulated acid secretion but not ... Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find ... Intraduodenal instillation of 0.20 M HCl or 1200 mOsm X kg-1 solution of polyethylene glycol (PEG) inhibited the maximal acid ... Hence, instillation of HCl and/or hyperosmolal PEG solution in the duodenum depresses the responsiveness of the parietal cells ...
Of 29 eyes that underwent excision and postoperative instillation of 0.02% mitomycin C, there were only two recurrences. The … ... Postoperative instillation of low-dose mitomycin C in the treatment of primary pterygium Am J Ophthalmol. 1988 Dec 15;106(6): ... We found the postoperative instillation of 0.02% mitomycin C, twice a day for five days, to be effective and safe in the ... The other eyes were treated with excision only, excision and radiation, or excision and 0.04% mitomycin C. Instillation of 0.02 ...
Instillation composition. US4309405 *. 30 Jan 1981. 5 Jan 1982. American Home Products Corporation. Sustained release ... In Example 7, the drug:gum ratio is about 1:5. In Example 8, the drug:gum ratio is about 1:6. In Example 9, the drug:gum ratio ... Sustained-release oral drug dosage form. US5015479. 30 Sep 1988. 14 May 1991. Seamus Mulligan. Sustained release capsule or ... Effect of Drug:Gum Ratio. In Examples 7-9, a sustained release excipient is prepared in accordance with the procedures set ...
... by intra-arterial instillation of vasoactive drugs. ...
New approved drug details including side effects, uses and general information. ... Burning upon instillation. Mechanism of Action. Akten is a gel formulation of the local anesthetic agent lidocaine. Akten ... The recommended initial dose of the drug is two drops applied to the ocular surface in the area of the planned procedure. Akten ... The following drug information is obtained from various newswires, published medical journal articles, and medical conference ...
Drug: Hexaminolevulinate hydrochloride (HCL) Instillation in bladder. Other Names: *Cysview®. *Hexvix®. Device: Karl Storz D- ... Drug: Hexaminolevulinate hydrochloride (HCL) Device: Karl Storz D-Light C Photodynamic Diagnostic (PDD) system ...
Provided by Stedmans medical dictionary and Drugs.com. Includes medical terms and definitions. ... Synonym(s): fluorescein instillation test. Further information. Always consult your healthcare provider to ensure the ... Drugs.com Mobile Apps. The easiest way to lookup drug information, identify pills, check interactions and set up your own ... Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and ...
The simian virus 40 (SV-40) early promoter linked to the Tn5 neomycin resistance gene provides resistance to the drug G-418 and ... Site-specific instillation of normal cells can be used to replace damaged cells, while instillation of transformed cells can be ... Instillation of cells in the walls of the patients blood vessels can be used to cause the steady perfusion of a therapeutic ... The section of the catheter body 4 situated between balloon means 1 and 2 is equipped with instillation port means 3. The ...
Treatment may include bladder distention; bladder instillation; oral drugs, such as the prescription drug Elmiron, ...
D. E. Kleiner, N. P. Chalasani, W. M. Lee et al., "Hepatic histological findings in suspected drug-induced liver injury: ... first reported that instillation of BCG could be used as an alternative to chemotherapy in the treatment of in situ ... Disseminated Granulomatous Disease from Intravesical Instillation of Bacillus Calmette-Guerin. Sayed Ab. Reshad Ghafouri,1 ... Intravesical instillation of Bacillus Calmette-Guerin is one of the standard treatment options for superficial bladder cancer. ...
Outcomes of bladder instillation/injection of drugs. An RCT of resiniferatoxin bladder instillations versus placebo found no ... Bladder instillation/injection of a drug. Another approach to treating urinary frequency, urgency, and urge incontinence is to ... Three studied bladder instillation or injection of drugs, one was of bladder distention and one was of bladder transection. ... Numerous drugs have been administered using this approach. Two categories of intravesical drugs are included in this review, ...
Very common (10% or more): Instillation site pain. Common (1% to 10%): Instillation site irritation, instillation site erythema ... Drugs.com Mobile Apps. The easiest way to lookup drug information, identify pills, check interactions and set up your own ... Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and ... Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. ...
New approved drug details including side effects, uses and general information. ... The recommended initial dose of the drug is instill 1 drop in the affected eye(s) twice daily, eight to twelve hours apart for ... The following drug information is obtained from various newswires, published medical journal articles, and medical conference ... Stinging and irritation upon instillation. *Contact dermatitis. *Corneal erosion. *Dry eye. *Dysgeusia ...
View Instillation Site Pain Genteal side effect risks. Female, 72 years of age, was diagnosed with dry eye, rheumatoid ... Is Instillation Site Pain a common side effect of Genteal? ... View, Report and Compare Drug Side Effects Over 350,000 side ... Foreign Body Sensation In Eyes, Instillation Site Pain This Instillation Site Pain Genteal Pm Lubricant Eye Ointment side ... Instillation Site Pain This Instillation Site Pain side effect was reported by a physician from US. A 72-year-old female ...
  • A transient burning sensation may occur upon instillation. (nih.gov)
  • The most frequent ocular adverse reactions, occurring in less than 4% of eyes treated with LASTACAFT®, were eye irritation, burning and/or stinging upon instillation, eye redness and eye pruritus. (globalrph.com)
  • Intratracheal instillation is the introduction of a substance directly into the trachea. (wikipedia.org)
  • Intratracheal instillation was reported as early as 1923 in studies of the carcinogenicity of coal tar. (wikipedia.org)
  • As compared to inhalation, intratracheal instillation allows greater control over the dose and location of the substance, is cheaper and less technically demanding, allows lower amounts of scarce or expensive substances to be used, allows substances to be tested that can be inhaled by humans but not small mammals, and minimizes exposure to laboratory workers and to the skin of laboratory animals. (wikipedia.org)
  • Intratracheal instillation is often performed with mice, rats, or hamsters, with hamsters often preferred because their mouth can be opened widely to aid viewing the procedure, and because they are more resistant to lung diseases than rats. (wikipedia.org)
  • Two different exposure modes were tested: sub-acute inhalation (4 hr/day, 5 d/week for 2 weeks, 3.5 mg/m(3)) and intratracheal instillation (24 hr post-exposure, 3, 35, and 100 µg/mouse). (cdc.gov)
  • AMI + Quercetin group was administered 2 intratracheal instillations of amiodarone on days 0 and 2 and 20mg/kg body weight of quercetin in 2% DMSO from day 0 for 3 weeks. (ajol.info)
  • Oral inhalative administration includes intratracheal inhalation and intratracheal instillation. (technavio.com)
  • Non-muscle-Invasive Bladder cancer is mainly treated by tumor resection (Trans Urethral Resection - TUR), followed by series of intravesical instillations of prophylactic chemotherapeutic drugs as Mitomycin C (MMC).This treatment approach is limited due to rapid dilution the chemotheraputic drug by the incoming urine and clearance by urination. (clinicaltrials.gov)
  • A meta-analysis found that a single instillation of chemotherapy immediately after transurethral resection of bladder tumor (TURBT) significantly decreased the risk of recurrence in patients with bladder cancer. (clinicaltrials.gov)
  • Indeed, a single early instillation of Docetaxel was found to reduce the post-TURBT bladder recurrence rate among patients with bladder cancer. (clinicaltrials.gov)
  • Case reports of M. bovis prosthetic joint infections after intravesical BCG instillation in patients with bladder cancer. (hindawi.com)
  • Intravesical instillation of Bacillus Calmette-Guerin is one of the standard treatment options for superficial bladder cancer. (hindawi.com)
  • Intravesical instillation of Bacillus Calmette-Guérin (BCG) is an efficient immunotherapy for superficial bladder cancer. (urotoday.com)
  • Spectrum Pharmaceuticals, Inc. ( SPPI ), a biotechnology company with fully integrated commercial and drug development operations with a primary focus in Hematology and Oncology, announced today the Company has enrolled the first patient in a Phase 3 trial of Qapzola, a potent tumor-activated drug being investigated for low and intermediate risk non-muscle invasive bladder cancer. (yahoo.com)
  • Under the SPA, this trial will evaluate the intravesical use of Qapzola in patients with non-muscle invasive bladder cancer (NMIBC), as a single instillation 60 ± 30 minutes, following transurethral resection of the bladder tumor (TURBT). (yahoo.com)
  • Qapzola is being developed for low-to-intermediate risk non-muscle invasive bladder cancer for which there are no approved drugs in the 21st century," said Rajesh C. Shrotriya, MD, Chairman and Chief Executive Officer of Spectrum Pharmaceuticals. (yahoo.com)
  • This is a novel drug that becomes cytotoxic only when it encounters hypoxic tumor such as non-muscle invasive bladder cancer. (yahoo.com)
  • In fact, the company was looking to get Qapzola approved for immediate intravesical instillation, post transurethral resection of bladder tumors (post-TURBT) in patients with non-muscle invasive bladder cancer (NMIBC). (yahoo.com)
  • Superficial bladder cancer lends itself to intravesical therapy due to the potential for direct contact between chemotherapeutic drug and tumor. (aacrjournals.org)
  • The purpose of this study was to assess the potential pulmonary effects of inhalation and instillation exposure to copper (Cu) NPs using a model of lung inflammation and host defense. (cdc.gov)
  • Both inhalation and instillation exposure to Cu NPs significantly decreased the pulmonary clearance of K.p.-exposed mice measured 24 hr after bacterial infection following Cu NP exposure versus sham-exposed mice also challenged with K.p (1.4 × 10(5) bacteria/mouse). (cdc.gov)
  • 0.05) were observed only in the saline group after surfactant instillation, whereas the decrease in pulmonary vascular resistance was not significant after surfactant instillation (p = 0.06). (biomedsearch.com)
  • Furthermore, pulmonary delivery offers improved bioavailability, biocompatibility and distribution of drugs to lung sites ( 8 ). (spandidos-publications.com)
  • Summary: Amiodarone, a drug that treats arrhythmias induces pulmonary toxicity through interplay between oxidative stress and inflammation. (ajol.info)
  • The aim of the present study was to evaluate the effects of quercetin on pulmonary responses in rats after amiodarone intra-tracheal instillation. (ajol.info)
  • Pulmonary delivery of drugs leads to the deposition of drugs in the lungs and subsequent local or systemic therapeutic activity. (technavio.com)
  • The pulmonary route of administration for the non-invasive delivery of drugs is mostly preferred because of the large surface area for absorption, high blood circulation, and high permeability rate. (technavio.com)
  • Pulmonary drug delivery offers various advantages over peroral routes, such as bypass of hepatic first-pass metabolism, quick onset of action, and low enzymatic activity. (technavio.com)
  • Pulmonary delivery of drugs can be achieved by intranasal administration or oral inhalative administration, the latter being more effective. (technavio.com)
  • The effective delivery of drugs via the pulmonary route requires an optimized combination of drug, its formulation, and device. (technavio.com)
  • TechNavio's analysts forecast the Global Pulmonary Drug Delivery Systems market to grow at a CAGR of 8.90 percent over the period 2014-2019. (technavio.com)
  • This report covers the present scenario and the growth prospects of the Global Pulmonary Drug Delivery Systems market for the period 2015-2019. (technavio.com)
  • TechNavio's report, the Global Pulmonary Drug Delivery Systems Market 2015-2019, has been prepared based on an in-depth market analysis with inputs from industry experts. (technavio.com)
  • it also covers the Global Pulmonary Drug Delivery Systems market landscape and its growth prospects in the coming years. (technavio.com)
  • In chronic gastric fistula rats provided with a duodenal loop anastomosed to the jejunum (Roux-en-Y), maximal stimulation of acid secretion by continuous intravenous infusion of pentagastrin produced a 15-fold increase of gastric histidine decarboxylase activity. (curehunter.com)
  • The a-wave and b-wave levels in addition to oscillatory potentials (OP) amplitude decreased in STZ rats two weeks after the injection of streptozotocin, with the instillation of CLZ nano attenuating these decreases. (mdpi.com)
  • In addition, the level of vascular endothelial growth factor (VEGF) in the retinas of STZ rats was 9.26-fold higher than in in normal rats, with this increase also prevented by the instillation of CLZ nano Thus, we have found that a-wave and b-wave levels in addition to OP amplitude are decreased in rats following the injection of excessive streptozotocin. (mdpi.com)
  • Eye drop instillation was difficult or very difficult for 10% of the elderly with the device aid and for 36% without it (p = 0.0047). (scielo.br)
  • The protocol includes a single instillation of Qapzola 60 ± 30 minute post-TURBT, to avoid inactivation of Qapzola by blood that is present after surgery. (yahoo.com)
  • The study evaluated Oncofid®P-B administered in 12 consecutive intravesical weekly instillations (intensive phase), followed in responsive patients by 12 monthly instillations (maintenance), in patients with bladder CIS, unresponsive or intolerant to BCG and unwilling or unfit for cystectomy. (prnewswire.com)
  • Patients treated with DMSO alone had a relapse rate of 52 percent, while those maintained with monthly instillations of heparin and followed for 12 months had a relapse rate of 20 percent. (ichelp.org)
  • Instillation results in a less uniform distribution of the substance than inhalation, and the substance is cleared from the respiratory tract more slowly. (wikipedia.org)
  • Oral inhalation delivers the aerosolized drug using devices such as MDIs (or pMDIs), PDIs, and nebulizers. (technavio.com)
  • The side effects of bladder instillation of heparin are limited primarily to pain, irritation, or discomfort resulting from frequent catheterization. (ichelp.org)
  • The patients will be randomized 2:1 to receive either 8 mg instillation of Qapzola or placebo post-TURBT. (yahoo.com)
  • In November 2016, Spectrum suffered a regulatory setback when the FDA issued a complete response letter (CRL) for its new drug application (NDA) for Qapzola. (yahoo.com)
  • Further dilute the reconstituted material from the vial (1 dose) in sterile, preservative-free saline to a final volume of 50 mL for intravesical instillation. (rxlist.com)
  • the saline group received saline i.v. at the same time point, and instillation of 200 mg/kg surfactant. (biomedsearch.com)
  • In contrast to the saline group, these variables were not modified in the L-NAME group after surfactant instillation. (biomedsearch.com)
  • Treatment mares received a uterine instillation of 100 ml of electrochemically activated (ECA) saline 4-12 hours post-insemination. (scielo.org.za)
  • Corneal epithelial permeability after instillation of ophthalmic solutions containing local anaesthetics and preservatives. (semanticscholar.org)
  • Assessment of the levels of MMC in patients urinary bladder following intravesical instillation of TC-3 mixed with MMC. (clinicaltrials.gov)
  • This side effect report can indicate a possible existence of increased vulnerability to Genteal treatment in female patients suffering from dry eye , eye pruritus , resulting in Instillation Site Pain . (patientsville.com)
  • Fifteen patients were submitted to 4 topical instillation of 0.6% besifloxacin. (arvojournals.org)
  • Thirteen patients were submitted to 4 topical instillation of 0.3% gatifloxacin. (arvojournals.org)
  • A control group of 15 patients did not receive topical application of antimicrobial drug before surgery. (arvojournals.org)
  • Up to one third of patients will not respond to these drugs, which are rarely used today for treatment of elevated IOP. (medscape.com)
  • BCG infection represents a major yet uncommon adverse event that occurs in 5-10% of the patients treated with BCG instillations, though the pathogenesis of this entity is not clear. (urotoday.com)
  • We report two cases of patients presented at our institution with BCG infection after instillation: one with microbiological BCG isolate and another without, and review all the medical records of patients instilled with BCG in our institution from 1996 until 2012, comparing patients with probable and proven BCG infection. (urotoday.com)
  • During the study period, a total of 786 patients received BCG intravesical instillations. (urotoday.com)
  • Regarding treatment, 8 (73%) of the 11 patients with BCG infection received at least two first line drugs active against M. bovis (isoniazid, rifampicin or ethambutol), four patients (36%) received steroids as part of the treatment and curation was obtained in 10 (91%) patients, while 1 patient with a proven infection had a death related to BCG infection. (urotoday.com)
  • The insertion of drugs into the rectum, usually for confused or incompetent patients, like children, infants, and the very old or comatose. (curehunter.com)
  • Sixty patients with myofascial pain syndrome in the upper trapezius muscle were randomly divided into two groups and assigned to receive either hot herbal compress or nonsteroidal anti - inflammatory drug (diclofenac) treatment for 2 weeks. (tripdatabase.com)
  • Many smaller clinics have already run out of the lifesaving drug, and larger hospitals - including New York's Memorial Sloan Kettering Cancer Center, where Field is being treated - have changed their policies on distributing BCG to prioritize newly diagnosed patients with active cancers. (statnews.com)
  • Adverse effects are due to systemic absorption of the drug, decreased cardiac output, and bronchoconstriction. (medscape.com)
  • The lacrimal sac should be compressed by digital pressure for two to three minutes after instillation to reduce excessive systemic absorption. (nih.gov)
  • Plasma samples drawn at time points up to 8 h were analyzed for systemic absorption and clearance of drug. (aacrjournals.org)
  • Instillation of drugs directly into the bladder - for instance dimethyl sulfoxide (DMSO). (netdoctor.co.uk)
  • However, the potential pathomechanisms of alveolar epithelial cell senescence and the impact of senolytic drugs on senescent lung cells and fibrosis remain unknown. (ersjournals.com)
  • Cysview contains hexaminolevulinate hydrochloride, an optical imaging drug that in solution form is instilled intravesically for use with photodynamic blue light cystoscopy as an adjunct to white light cystoscopy. (rxlist.com)
  • skin exposure to hexaminolevulinate hydrochloride may increase the risk for sensitization to the drug. (rxlist.com)
  • Drug instillation, also known as medication instillation, is the administration of a medicine, generally in liquid form either drop by drop or with a catheter into a body space or cavity. (wikipedia.org)
  • The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. (drugs.com)
  • Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. (drugs.com)
  • Wash your hands and if necessary your child's hands after instillation to remove any medication. (medlineplus.gov)
  • Your doctor may have suggested this medication for conditions other than those listed in these drug information articles. (medbroadcast.com)
  • Valrubicin is an anti-cancer ("antineoplastic" or "cytotoxic") chemotherapy drug. (chemocare.com)
  • To heat the bladder wall concomitant with intravesical instillation of a chemotherapy drug. (fda.gov)
  • The instillation of drops is the main route of ocular administration used for the treatment of diseases of the anterior segment. (scielo.br)
  • Daily online exclusives cover late breaking oncology news, safe handling and administration of chemotherapy drugs, side effect management, and new developments in specific cancers. (oncologynurseadvisor.com)
  • By contrast, tracheal administration of pharmaceutical drugs in humans is called endotracheal administration. (wikipedia.org)
  • Aerosol drug administration. (cengage.com)
  • A Special Protocol Assessment is a written agreement between a Sponsor and the U.S. Food and Drug Administration on the design, execution and analysis for a clinical trial that may form the basis of a new drug application, or NDA. (yahoo.com)
  • n = 6) received 100 mg, 350 mg, or 1 g of drug by intravesical administration on alternate days three times/week for 4 weeks. (aacrjournals.org)
  • Aerie's retina program continues to advance with the IND (Investigational New Drug application) for AR-13503 (Rho kinase and Protein kinase C inhibitor implant) accepted by the FDA (the U.S. Food and Drug Administration) in April 2019. (businesswire.com)
  • Aerie received approval from the U.S. Food and Drug Administration (FDA) in January 2020 to produce Rocklatan ® in Aerie's Athlone, Ireland, manufacturing facility for commercial distribution in the U.S. market. (businesswire.com)
  • After extensive research in digital databases like LILACS, PubMed, and Scielo we didin't find any studies on the perception and technical adequacy of self instillation of eye drops only in the elderly. (scielo.br)
  • The present study aims to study the perception and technical adequacy of the elderly in relation to self instillation of eye drops with and without Eyedrop ® facial support device. (scielo.br)
  • The recommended initial dose of the drug is two drops applied to the ocular surface in the area of the planned procedure. (centerwatch.com)
  • The classes of medications that have the potential to induce angle closure are topical anticholinergic or sympathomimetic dilating drops, tricyclic antidepressants, monoamine oxidase inhibitors, antihistamines, antiparkinsonian drugs, antipsychotic medications, and antispasmolytic agents. (medscape.com)
  • Because many drugs are excreted in human milk, caution should be exercised when cyclopentolate hydrochloride is administered to a nursing woman. (nih.gov)
  • One intravesical instillation of 40 cc of TC-3 hydrogel is instilled using catheter. (clinicaltrials.gov)
  • To avoid cross-contamination, do not prepare parenteral drugs in areas where TheraCys has been prepared. (rxlist.com)
  • While this drug can be given either by injection or by bladder instillation, the method of choice for the treatment of IC is bladder instillation. (ichelp.org)
  • The purpose of this study is to evaluate the safety of intravesical instillation of TC-3 Hydrogel disposable device for retention of mitomycin C chemotherapeutic drug in the urinary bladder. (clinicaltrials.gov)
  • Because of the high recurrence rates, both professional urology associations and NCCN Guidelines recommend instillation of a cytotoxic agent following TURBT for NMIBC, although in the U.S., there are no FDA-approved agents for this indication. (yahoo.com)
  • The thin barrier and high permeability of this membrane make the lungs an optimal site for systemic and local delivery of drugs. (spandidos-publications.com)
  • Several different drugs have the potential to cause the elevation of intraocular pressure (IOP), which can occur via an open-angle mechanism or a closed-angle mechanism. (medscape.com)
  • The investigators evaluated the efficacy of a single early intravesical instillation of doxetaxel in the prevention of bladder recurrence after nephroureterectomy or distal ureterectomy for upper urinary tract urothelial carcinoma (UUT-UC). (clinicaltrials.gov)
  • In this prospective, randomized study, the investigators evaluated the efficacy of a single, early, intravesical instillation of Docetaxel in the prevention of bladder recurrence after nephroureterectomy for UUT-UC. (clinicaltrials.gov)
  • The other eyes were treated with excision only, excision and radiation, or excision and 0.04% mitomycin C. Instillation of 0.02% mitomycin C reduced the recurrence rate significantly (P less than .01). (nih.gov)
  • Following one instillation of study drug and a safety follow-up at Day 35, subsequent follow up visits will be conducted until tumor recurrence or end of study, whichever occurs first. (yahoo.com)
  • NMIBC is the fifth most common cancer in the U.S. and is an unmet medical need due to high recurrence rates and no FDA-approved drugs. (yahoo.com)
  • Second-line therapy in metastatic renal cell cancer-how do we treat after immuno-oncology drugs? (springermedizin.at)
  • Successful gene therapy requires stability and sufficient bioavailability of the applied drug at the site of action. (fraunhofer.de)
  • Another possible therapy for them is the drug Elmiron (please see below). (netdoctor.co.uk)
  • Because the goal is for all residents to receive optimal drug therapy, the surveyor's objective is to validate the appropriateness of the facility's drug delivery system, specifically the technique used. (thefreelibrary.com)
  • 16. Ott R S 1986 The efficacy of uterine treatment with antimicrobial drugs. (scielo.org.za)
  • Thereupon, the treatment of the tumour began with transurethral resection technique and intravesical instillation of Calmette-Guérin Bacillus as adjuvant treatment. (biomedcentral.com)
  • Here again, potent antitumor effects on established tumors were achieved by intraductal instillation of Doxil. (hopkinsmedicine.org)
  • Donna Hoff, a 71-year-old retired bookkeeper, had her bladder tumors surgically removed, then was put on a regimen of BCG combined with interferon, another drug that boosts immune response. (statnews.com)
  • D-Amino Acids Boost the Selectivity and Confer Supramolecular Hydrogels of a Non - steroidal Anti - inflammatory Drug ( NSAID ) As systemically used therapeutics for treating acute or chronic pains or inflammations, nonsteroidal anti - inflammatory drugs ( NSAIDs ) also associate with the adverse gastrointestinal and renal effects and cardiovascular risks. (tripdatabase.com)
  • The nanodrug delivery system is the application of nanotechnology in the pharmaceutical field, and has shown development prospects in targeted diagnosis and treatment, delaying drug release, improving drug solubility and availability, reducing drug side effects and overcoming barriers of the human body ( 6 ). (spandidos-publications.com)
  • This information will help you understand how side effects, such as Instillation Site Pain, can occur, and what you can do about them. (patientsville.com)
  • In general, local adverse reactions occur during or shortly after instillation and resolve within 1-7 days. (chemocare.com)
  • Used concomitantly with other topical ophthalmic drug products to lower IOP. (medscape.com)
  • If more than one topical ophthalmic drug is being used, the drugs should be administered at least five (5) minutes apart. (amazonaws.com)
  • 7 h) suggests that once or twice a daily topical instillation should be sufficient to maintain exposure in target tissues above therapeutic concentration levels. (arvojournals.org)
  • This mode of delivery can achieve therapeutic effects with less than one-third the systemic dose of the drug. (hopkinsmedicine.org)
  • Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. (curehunter.com)
  • Realize the full power of the drug-disease research network! (curehunter.com)
  • We present a case of a 72-year-old man with disseminated granulomatous disease from intravesical BCG instillation whose treatment was complicated by antimycobacterial drug toxicity. (hindawi.com)
  • We present a case of disseminated granulomatous disease secondary to BCG treatment, complicated by antimycobacterial drug toxicity. (hindawi.com)
  • This symposium will highlight the latest data on the function and regulation of bioactive lipids across a variety of cardiometabolic diseases such as cardiovascular disease, Type-II Diabetes, fatty liver disease and obesity, with the aim of identifying common pathways that present novel drug targets. (nyas.org)
  • The pathophysiology of drug-induced angle-closure glaucoma is usually increased pupillary block (ie, increased iris-lens contact at the pupillary border) from pupillary dilation. (medscape.com)
  • Assessment of systemic and urine pharmacokinetics of MMC following intravesical instillation of TC-3 mixed with MMC for safety evaluation. (clinicaltrials.gov)
  • Drug-induced elevation of IOP is more common by an open-angle mechanism. (medscape.com)
  • Corticosteroids are a class of drugs that may produce IOP elevation by this mechanism. (medscape.com)
  • We conclude that the vasodilatory effect of porcine surfactant instillation in newborn piglets with surfactant deficiency is associated with activation of NO synthase. (biomedsearch.com)
  • We can conclude that BCG infection after intravesical instillations has a low incidence in our institution. (urotoday.com)
  • To determine the degree of difficulty for topical ocular instillation in the elderly, through a questionnaire, with or without the aid of facial support device. (scielo.br)
  • The facial support device increased security and facility in instillation. (scielo.br)
  • and includes the sale or dispensing of a drug, vaccine, appliance, device, equipment or other item pursuant to a prescription. (gov.mb.ca)
  • The recommended initial dose of the drug is instill 1 drop in the affected eye(s) twice daily, eight to twelve hours apart for the first two days and then instill 1 drop in the affected eye (s) once daily for the next five days. (centerwatch.com)
  • In addition, it is difficult for most drugs to reach the lower respiratory tract with adequate dose and minimum side effects. (spandidos-publications.com)