Intracellular receptors that bind to INOSITOL 1,4,5-TRISPHOSPHATE and play an important role in its intracellular signaling. Inositol 1,4,5-trisphosphate receptors are calcium channels that release CALCIUM in response to increased levels of inositol 1,4,5-trisphosphate in the CYTOPLASM.
The state of weariness following a period of exertion, mental or physical, characterized by a decreased capacity for work and reduced efficiency to respond to stimuli.
Intracellular messenger formed by the action of phospholipase C on phosphatidylinositol 4,5-bisphosphate, which is one of the phospholipids that make up the cell membrane. Inositol 1,4,5-trisphosphate is released into the cytoplasm where it releases calcium ions from internal stores within the cell's endoplasmic reticulum. These calcium ions stimulate the activity of B kinase or calmodulin.
Databases containing information about PROTEINS such as AMINO ACID SEQUENCE; PROTEIN CONFORMATION; and other properties.
Phosphoric acid esters of inositol. They include mono- and polyphosphoric acid esters, with the exception of inositol hexaphosphate which is PHYTIC ACID.
Intracellular receptors that can be found in the cytoplasm or in the nucleus. They bind to extracellular signaling molecules that migrate through or are transported across the CELL MEMBRANE. Many members of this class of receptors occur in the cytoplasm and are transported to the CELL NUCLEUS upon ligand-binding where they signal via DNA-binding and transcription regulation. Also included in this category are receptors found on INTRACELLULAR MEMBRANES that act via mechanisms similar to CELL SURFACE RECEPTORS.
Voltage-dependent cell membrane glycoproteins selectively permeable to calcium ions. They are categorized as L-, T-, N-, P-, Q-, and R-types based on the activation and inactivation kinetics, ion specificity, and sensitivity to drugs and toxins. The L- and T-types are present throughout the cardiovascular and central nervous systems and the N-, P-, Q-, & R-types are located in neuronal tissue.
A basic element found in nearly all organized tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes.
An isomer of glucose that has traditionally been considered to be a B vitamin although it has an uncertain status as a vitamin and a deficiency syndrome has not been identified in man. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1379) Inositol phospholipids are important in signal transduction.
A procedure consisting of a sequence of algebraic formulas and/or logical steps to calculate or determine a given task.
A mature haploid female germ cell extruded from the OVARY at OVULATION.
The fusion of a spermatozoon (SPERMATOZOA) with an OVUM thus resulting in the formation of a ZYGOTE.
Movement characteristics of SPERMATOZOA in a fresh specimen. It is measured as the percentage of sperms that are moving, and as the percentage of sperms with productive flagellar motion such as rapid, linear, and forward progression.
The structural and functional changes by which SPERMATOZOA become capable of oocyte FERTILIZATION. It normally requires exposing the sperm to the female genital tract for a period of time to bring about increased SPERM MOTILITY and the ACROSOME REACTION before fertilization in the FALLOPIAN TUBES can take place.
Mature male germ cells derived from SPERMATIDS. As spermatids move toward the lumen of the SEMINIFEROUS TUBULES, they undergo extensive structural changes including the loss of cytoplasm, condensation of CHROMATIN into the SPERM HEAD, formation of the ACROSOME cap, the SPERM MIDPIECE and the SPERM TAIL that provides motility.
The posterior filiform portion of the spermatozoon (SPERMATOZOA) that provides sperm motility.
Changes that occur to liberate the enzymes of the ACROSOME of a sperm (SPERMATOZOA). Acrosome reaction allows the sperm to penetrate the ZONA PELLUCIDA and enter the OVUM during FERTILIZATION.
An annexin family member that plays a role in MEMBRANE FUSION and signaling via VOLTAGE-DEPENDENT CALCIUM CHANNELS.
The cap-like structure covering the anterior portion of SPERM HEAD. Acrosome, derived from LYSOSOMES, is a membrane-bound organelle that contains the required hydrolytic and proteolytic enzymes necessary for sperm penetration of the egg in FERTILIZATION.
A tough transparent membrane surrounding the OVUM. It is penetrated by the sperm during FERTILIZATION.
Calcium-transporting ATPases that catalyze the active transport of CALCIUM into the SARCOPLASMIC RETICULUM vesicles from the CYTOPLASM. They are primarily found in MUSCLE CELLS and play a role in the relaxation of MUSCLES.
Cation-transporting proteins that utilize the energy of ATP hydrolysis for the transport of CALCIUM. They differ from CALCIUM CHANNELS which allow calcium to pass through a membrane without the use of energy.
A sesquiterpene lactone found in roots of THAPSIA. It inhibits CA(2+)-TRANSPORTING ATPASE mediated uptake of CALCIUM into SARCOPLASMIC RETICULUM.
A network of tubules and sacs in the cytoplasm of SKELETAL MUSCLE FIBERS that assist with muscle contraction and relaxation by releasing and storing calcium ions.
A system of cisternae in the CYTOPLASM of many cells. In places the endoplasmic reticulum is continuous with the plasma membrane (CELL MEMBRANE) or outer membrane of the nuclear envelope. If the outer surfaces of the endoplasmic reticulum membranes are coated with ribosomes, the endoplasmic reticulum is said to be rough-surfaced (ENDOPLASMIC RETICULUM, ROUGH); otherwise it is said to be smooth-surfaced (ENDOPLASMIC RETICULUM, SMOOTH). (King & Stansfield, A Dictionary of Genetics, 4th ed)
Phosphatidylinositols in which one or more alcohol group of the inositol has been substituted with a phosphate group.
The parts of a macromolecule that directly participate in its specific combination with another molecule.
The rate dynamics in chemical or physical systems.
The part of brain that lies behind the BRAIN STEM in the posterior base of skull (CRANIAL FOSSA, POSTERIOR). It is also known as the "little brain" with convolutions similar to those of CEREBRAL CORTEX, inner white matter, and deep cerebellar nuclei. Its function is to coordinate voluntary movements, maintain balance, and learn motor skills.
Cell membrane glycoproteins that form channels to selectively pass chloride ions. Nonselective blockers include FENAMATES; ETHACRYNIC ACID; and TAMOXIFEN.
The span of viability of a cell characterized by the capacity to perform certain functions such as metabolism, growth, reproduction, some form of responsiveness, and adaptability.
A protein-serine-threonine kinase that is activated by PHOSPHORYLATION in response to GROWTH FACTORS or INSULIN. It plays a major role in cell metabolism, growth, and survival as a core component of SIGNAL TRANSDUCTION. Three isoforms have been described in mammalian cells.
A promyelocytic cell line derived from a patient with ACUTE PROMYELOCYTIC LEUKEMIA. HL-60 cells lack specific markers for LYMPHOID CELLS but express surface receptors for FC FRAGMENTS and COMPLEMENT SYSTEM PROTEINS. They also exhibit phagocytic activity and responsiveness to chemotactic stimuli. (From Hay et al., American Type Culture Collection, 7th ed, pp127-8)
A highly polar organic liquid, that is used widely as a chemical solvent. Because of its ability to penetrate biological membranes, it is used as a vehicle for topical application of pharmaceuticals. It is also used to protect tissue during CRYOPRESERVATION. Dimethyl sulfoxide shows a range of pharmacological activity including analgesia and anti-inflammation.
Techniques to partition various components of the cell into SUBCELLULAR FRACTIONS.
Direct contact of a cell with a neighboring cell. Most such junctions are too small to be resolved by light microscopy, but they can be visualized by conventional or freeze-fracture electron microscopy, both of which show that the interacting CELL MEMBRANE and often the underlying CYTOPLASM and the intervening EXTRACELLULAR SPACE are highly specialized in these regions. (From Alberts et al., Molecular Biology of the Cell, 2d ed, p792)
One of the two major classes of cholinergic receptors. Muscarinic receptors were originally defined by their preference for MUSCARINE over NICOTINE. There are several subtypes (usually M1, M2, M3....) that are characterized by their cellular actions, pharmacology, and molecular biology.
The lipid- and protein-containing, selectively permeable membrane that surrounds the cytoplasm in prokaryotic and eukaryotic cells.
Structural studies of inositol 1,4,5-trisphosphate receptor: coupling ligand binding to channel gating.. J. Biol. Chem. 285 ... GO:0070679 inositol 1,4,5 trisphosphate binding GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel ... The inositol 1,4,5-trisphosphate (IP3)3 receptor (IP3R) are tetrameric intracellular Ca2+ release channels on the endoplasmic ... Tyr-167/Trp-168 in type 1/3 inositol 1,4,5-trisphosphate receptor mediates functional coupling between ligand binding and ...
Identification of a family of calcium sensors as protein ligands of inositol trisphosphate receptor Ca(2+) release channels. ... Type 3 InsP3 receptor. Gene Name. ITPR3. Organism. Humans. Amino acid sequence. ,lcl,BSEQ0019643,Inositol 1,4,5-trisphosphate ... Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium.. Specific ... calcium ion transport into cytosol / G-protein coupled receptor signaling pathway / long-term synaptic potentiation / memory / ...
Thus, an inositol trisphosphate receptor can act as a RAS-independent, tissue-specific positive effector of LET-23. An inositol ... Hajnoczky, G. and Thomas, A. P. (1994). The inositol trisphosphate calcium channel is inactivated by inositol trisphosphate. ... Two receptor classes (the G protein-coupled receptor class of seven transmembrane-spanning receptors and the receptor tyrosine ... of the inositol trisphosphate receptor (Sayers, 1997). Inositol 1,4,5-trisphosphate receptor (InsP3R) is an inositol InsP3- ...
... Cell. 1995 Nov 3;83(3 ... Calcineurin anchored to the IP3R via FKBP12 regulates the phosphorylation status of the receptor, resulting in a dynamic Ca(2+ ... We now report that calcineurin is physiologically associated with the IP3R-FKBP12 and RyR-FKBP12 receptor complexes and that ... A M Cameron 1 , J P Steiner, A J Roskams, S M Ali, G V Ronnett, S H Snyder ...
Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. This release ... Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. This release ... Inositol 1,4,5-trisphosphate receptor type 2Add BLAST. 2701. Amino acid modifications. Feature key. Position(s). Description ... Inositol 1,4,5-trisphosphate bindingBy similarity. 5. ,p>This subsection of the Family and Domains section describes a region ...
Inositol 1,4,5-trisphosphate receptor type 2Imported. ,p>Information which has been imported from another database using ... tr,B2KF89,B2KF89_MOUSE Inositol 1,4,5-trisphosphate receptor type 2 (Fragment) OS=Mus musculus GN=Itpr2 PE=1 SV=1 ... 1. Imported. ,p>Information which has been imported from another database using automatic procedures.,/p> ,p>,a href="/manual/ ... Annotation score:1 out of 5. ,p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB ...
Keywords: 2-APB; Ca2+ signal; DT40 cell; IP3 receptor; Xestospongin; antagonist; caffeine; heparin; inositol 1,4,5- ... Interactions of antagonists with subtypes of inositol 1,4,5-trisphosphate (IP3) receptor Br J Pharmacol. 2014 Jul;171(13):3298- ... Background and purpose: Inositol 1,4,5-trisphosphate receptors (IP3 Rs) are intracellular Ca(2+) channels. Interactions of the ... Huma Saleem 1 , Stephen C Tovey, Tedeusz F Molinski, Colin W Taylor ...
... and of the type 3 InsP3 receptor (InsP3R-3). InsP3R down-regulation was a cell- and agonist-specific process, since several ... Sipma H1, Deelman L, Smedt HD, Missiaen L, Parys JB, Vanlingen S, Henning RH, Casteels R. ... 1. Laboratorium voor Fysiologie, Campus Gasthuisberg O/N, KU Leuven, Belgium.. Abstract. Prolonged stimulation of rat A7r5 ... other agonists acting on PLC-coupled receptors did not change the expression level of the InsP3R isoforms in these cell types ...
In mouse eggs, these oscillations cease after a variable period of time and this is accompanied by a decrease in inositol 1,4,5 ... trisphosphate receptor (IP3R) responsiveness and down-regulation of the IP3R type 1 (IP3R-1). To investigate the signaling ... Down-regulation of the inositol 1,4,5-trisphosphate receptor in mouse eggs following fertilization or parthenogenetic ... Jellerette T1, He CL, Wu H, Parys JB, Fissore RA.. Author information. 1. Department of Veterinary and Animal Sciences, ...
Han-Chen Ho and Susan S. Suarez "An Inositol 1,4,5-Trisphosphate Receptor-Gated Intracellular Ca2 Store Is Involved in ... An Inositol 1,4,5-Trisphosphate Receptor-Gated Intracellular Ca2 Store Is Involved in Regulating Sperm Hyperactivated Motility ... Han-Chen Ho, Susan S. Suarez "An Inositol 1,4,5-Trisphosphate Receptor-Gated Intracellular Ca2 Store Is Involved in Regulating ... Indirect immunofluorescence labeling showed type I inositol 1,4,5-trisphosphate receptors (IP3R) in the acrosome and neck ...
The inositol 1,4,5-trisphosphate (IP3) receptor (IP3R) acts as a Ca2+ release channel on internal Ca2+ stores. Type 1 IP3R (IP3 ... Regulation of Nerve Growth Mediated by Inositol 1,4,5-Trisphosphate Receptors in Growth Cones ... Regulation of Nerve Growth Mediated by Inositol 1,4,5-Trisphosphate Receptors in Growth Cones ... Regulation of Nerve Growth Mediated by Inositol 1,4,5-Trisphosphate Receptors in Growth Cones ...
2004) NMDA-receptor regulation of muscarinic-receptor stimulated inositol 1,4,5-trisphosphate production and protein kinase C ... 1991) Role for ionotropic and metabotropic receptors in quisqualate-stimulated inositol polyphosphate accumulation in rat ... 2004) Synaptic activity augments muscarinic acetylcholine receptor-stimulated inositol 1,4,5-trisphosphate production to ... We also observed a defect of the increase in BDNF production after AMPA receptor (AMPAR) and metabotropic glutamate receptor ( ...
Inositol 1,4,5-trisphosphate receptors selectively localized to the acrosomes of mammalian sperm.. L D Walensky, S H Snyder ... We have characterized inositol 1,4,5-trisphosphate (IP3)-gated calcium channels and upstream components of the phosphoinositide ... Western blotting using a polyclonal antibody directed against purified brain IP3 receptor (IP3R) identified a specific 260 kD ... Inositol 1,4,5-trisphosphate receptors selectively localized to the acrosomes of mammalian sperm. ...
Narayanan D, Adebiyi A, Jaggar JH (2012) Inositol trisphosphate receptors in smooth muscle cells. Am J Physiol Heart Circ ... Berridge MJ (2016) The inositol trisphosphate/calcium signaling pathway in health and disease. Physiol Rev 96:1261-1296CrossRef ... Lencesova L, Krizanova O (2012) IP(3) receptors, stress and apoptosis. Gen Physiol Biophys 31:119-130CrossRefGoogle Scholar ... Mikoshiba K (2015) Role of IP3 receptor signaling in cell functions and diseases. Adv Biol Regul 57:217-227CrossRefGoogle ...
P3 receptor co-purified. Immunofluorescence studies demonstrated that both type-1 Ins(1,4,5)P3 receptor and SERCA2 were evenly ... P3 receptor reside either in the same or two tightly associated subcellular compartments. ... P3 receptor. In subcellular fractionation studies, SERCA2 and type-1 Ins(1,4,5) ... Taken together, our results suggest that in myeloid cells (i) SERCA-type Ca2+-ATPases function as Ca2+ pumps of Ins(1,4,5)P3- ...
P3-binding site of hepatocytes is likely to be the receptor that mediates Ca2+ mobilization, and that this receptor is at ... Liver inositol, 1,4,5-trisphosphate-binding sites are the Ca2(+)-mobilizing receptors. D L Nunn, C W Taylor ... Liver inositol, 1,4,5-trisphosphate-binding sites are the Ca2(+)-mobilizing receptors ... Liver inositol, 1,4,5-trisphosphate-binding sites are the Ca2(+)-mobilizing receptors ...
Phosphorylation of inositol 1,4,5-trisphosphate receptors by protein kinase B/Akt inhibits Ca2+ release and apoptosis ... Phosphorylation of inositol 1,4,5-trisphosphate receptors by protein kinase B/Akt inhibits Ca2+ release and apoptosis.. ... We identified Ca2+ release through inositol 1,4,5-trisphosphate receptor (InsP3R) intracellular channels as a prosurvival ...
Caffeine protects against experimental acute pancreatitis by inhibition of inositol 1,4,5-trisphosphate receptor-mediated Ca2+ ... Caffeine protects against experimental acute pancreatitis by inhibition of inositol 1,4,5-trisphosphate receptor-mediated Ca2+ ...
... mobilizing inositol phosphates and other inositol phosphates which also bind to the purified InsP3 receptor, suggesting that ... The results suggest that there is an absolute increase in the level of the InsP3 receptor during HL-60 cell differentiation and ... Increased expression of the inositol 1,4,5-trisphosphate receptor in human leukaemic (HL-60) cells differentiated with retinoic ... Increased expression of the inositol 1,4,5-trisphosphate receptor in human leukaemic (HL-60) cells differentiated with retinoic ...
Inositol trisphosphate receptor Ca2+ release channels in neurological diseases. Pflugers Arch. 460:481-494. doi:10.1007/s00424- ... Regulation of inositol trisphosphate receptors by luminal Ca2+ contributes to quantal Ca2+ mobilization. EMBO J. 15:2086-2093. ... Inositol trisphosphate receptor Ca2+ release channels. Physiol. Rev. 87:593-658. doi:10.1152/physrev.00035.2006. ... Structure and function of inositol trisphosphate receptors. Pharmacol. Ther. 51:97-137. doi:10.1016/0163-7258(91)90043-L. ...
Recombinant Protein and Inositol 1,4,5-trisphosphate receptor-interacting protein Antibody at MyBioSource. Custom ELISA Kit, ... Shop Inositol 1,4,5-trisphosphate receptor-interacting protein ELISA Kit, ... Inositol 1,4,5-trisphosphate receptor-interacting protein. LOG IN MY ACCOUNT CART CONTENTS CHECKOUT ... Inositol 1,4,5-trisphosphate receptor-interacting protein-like 1 Antibody. Itpripl1 ELISA Kit. Itpripl1 Recombinant. Itpripl1 ...
Although the ryanodine receptor type 2, another type of intracellular Ca2+ release channel, has been shown to play a role in ... BACKGROUND Inositol 1,4,5-trisphosphate receptors (IP3R1, 2, and 3) are intracellular Ca2+ release channels that regulate ... trisphosphate receptors and their protein partners as signalling hubs. *David L Prole, Colin W Taylor ... Regulation of hair shedding by the type 3 IP3 receptor.. *Mai Sato-Miyaoka, Chihiro Hisatsune, Etsuko Ebisui, Naoko Ogawa, ...
EGF receptor; IP3R, inositol 1,4,5-trisphosphate receptor; IP3R1, IP3R type 1; NMDA, N-methyl-d-aspartic acid; PKA, cAMP- ... Phosphorylation of inositol 1,4,5-trisphosphate receptors by cAMP-dependent protein kinase. Type I, II, and III receptors are ... Phosphorylation of inositol 1,4,5-trisphosphate receptors by cAMP-dependent protein kinase. Type I, II, and III receptors are ... Phosphorylation of inositol 1,4,5-trisphosphate receptors in parotid acinar cells. A mechanism for the synergistic effects of ...
Multiple, coordinated Ca2+- release events underlie the inositol trisphosphate-induced local Ca2+spikes in mouse pancreatic ... Multiple, coordinated Ca2+- release events underlie the inositol trisphosphate-induced local Ca2+spikes in mouse pancreatic ... Putative receptor for inositol 1,4,5-trisphosphate similar to ryanodine receptor ... Putative receptor for inositol 1,4,5-trisphosphate similar to ryanodine receptor ...
Przyklenk K, Maynard M, Whittaker P. First molecular evidence that inositol trisphosphate signaling contributes to infarct size ... anti-GAGAB receptors, anti-LGI1, anti-CASPR2, anti-glycine receptors, anti-ganglioside antibodies) was negative. ... T-cell receptor analysis in anti-Hu associated paraneoplastic encephalomyelitis. Neurology. 1998;51:1146-50.View ArticlePubMed ... Inositol 1, 4, 5-trisphosphate receptors and human left ventricular myocytes. Circulation. 2013;128:1286-97.View ArticlePubMed ...
A monoclonal antibody to the IP3 receptor inhibited both IICR and CICR upon injection of IP3 and Ca2+ into hamster eggs, ... The results indicate that Ca2+ release in fertilized hamster eggs is mediated solely by the IP3 receptor, and Ca(2+)-sensitized ... These phenomena are explained by inositol 1,4,5-trisphosphate (IP3)-induced Ca2+ release (IICR) and Ca(2+)-induced Ca2+ release ... Regulation of calcium spiking in mammalian oocytes through a combination of inositol trisphosphate-dependent entry and release. ...
... correction of tris-phosphate] activation of inositol trisphosphate [correction of tris-phosphate] receptor Ca2+ channel by ... Inositol trisphosphate receptor Ca2+ release channels. Physiol Rev 87(2): 593-658,2007. PMID: 17429043. ... Surface accessibility and conformational changes in the N-terminal domain of type I inositol trisphosphate receptors: studies ... Calcium-dependent conformational changes in inositol trisphosphate receptors. J Biol Chem 285(32): 25085-25093,2010. PMID: ...
The inositol 1,4,5 trisphosphate (IP3) receptor (IP 3R) is a Ca2+ release channel that responds to the second messenger IP3. ... N2 - The inositol 1,4,5 trisphosphate (IP3) receptor (IP 3R) is a Ca2+ release channel that responds to the second messenger ... AB - The inositol 1,4,5 trisphosphate (IP3) receptor (IP 3R) is a Ca2+ release channel that responds to the second messenger ... Inositol 1,4,5-trisphosphate receptors as signal integrators. / Patterson, Randen L.; Boehning, Darren; Snyder, Solomon H. ...
The characteristic binding pattern as well as double staining experiments suggested inositol 1,4,5-trisphosphate receptor type ... up to 1:5,000) IgG antibodies, mainly IgG1, to the molecular layer, Purkinje cell layer, and white matter on mouse, rat, ... 1 (ITPR1) as the target antigen. Verification of the antigen included specific neutralization of the tissue reaction following ... From: Antibodies to the inositol 1,4,5-trisphosphate receptor type 1 (ITPR1) in cerebellar ataxia ...
  • The inositol 1,4,5-trisphosphate (IP3)3 receptor (IP3R) are tetrameric intracellular Ca2+ release channels on the endoplasmic membrane that are activated by the ligand IP3 [ PMID: 20813840 ]. (ebi.ac.uk)
  • Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. (drugbank.ca)
  • Inositol 1,4,5-trisphosphate receptors (IP3 Rs) are intracellular Ca(2+) channels. (nih.gov)
  • In this study, we found the specific expression of type 2 inositol 1,4,5-trisphosphate receptor (IP 3 R2), which is an intracellular Ca 2+ release channel, on the sarco/endoplasmic reticulum in mouse PASMCs, and demonstrated its inhibitory role in the progression of PAH using a chronic hypoxia-induced PAH mouse model. (springer.com)
  • Ins(1,4,5)P3 is the intracellular messenger that in many cells mediates the effects of Ca2(+)-mobilizing receptors on intracellular Ca2+ stores. (biochemj.org)
  • We identified Ca 2+ release through inositol 1,4,5-trisphosphate receptor (InsP 3 R) intracellular channels as a prosurvival target of PKB. (open.ac.uk)
  • The ubiquitous inositol 1,4,5-trisphosphate (InsP 3 ) receptor (InsP 3 R) Ca 2+ release channel plays a central role in the generation and modulation of intracellular Ca 2+ signals, and is intricately regulated by multiple mechanisms including cytoplasmic ligand (InsP 3 , free Ca 2+ , free ATP 4− ) binding, posttranslational modifications, and interactions with cytoplasmic and endoplasmic reticulum (ER) luminal proteins. (rupress.org)
  • BACKGROUND Inositol 1,4,5-trisphosphate receptors (IP3R1, 2, and 3) are intracellular Ca2+ release channels that regulate various vital processes. (semanticscholar.org)
  • Although the ryanodine receptor type 2, another type of intracellular Ca2+ release channel, has been shown to play a role in embryonic cardiomyocytes, the functions of the IP3Rs in cardiogenesis remain unclear. (semanticscholar.org)
  • These phenomena are explained by inositol 1,4,5-trisphosphate (IP3)-induced Ca2+ release (IICR) and Ca(2+)-induced Ca2+ release (CICR) from separate intracellular stores, but decisive evidence is lacking. (semanticscholar.org)
  • [2] Inositol triphosphate receptor represents a dominant second messenger leading to the release of Ca 2+ from intracellular store sites. (wikipedia.org)
  • Their activation results in phosphatidylinositol 4,5-bisphosphate (PIP 2 ) hydrolysis and Ca 2+ release from intracellular stores via the phospholipase C (PLC)-inositol 1,4,5-trisphosphate (IP 3 ) signaling pathway. (jneurosci.org)
  • This leads to hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP 2 ) and generation of diacylglycerol and inositol 1,4,5-trisphosphate (IP 3 ), resulting in activation of protein kinase C (PKC) and Ca 2+ release from intracellular stores, respectively ( Berridge, 1993 ). (jneurosci.org)
  • Intracellular messenger formed by the action of phospholipase C on phosphatidylinositol 4,5-bisphosphate, which is one of the phospholipids that make up the cell membrane. (jove.com)
  • Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5-trisphosphate (PubMed:27108797). (nih.gov)
  • This gene encodes an intracellular receptor for inositol 1,4,5-trisphosphate. (nih.gov)
  • Changes in free intracellular calcium levels ([Ca] ) are mediated either by the influx of Ca from the extracellular space or release of Ca from intracellular stores, mainly the sarcoplasmic reticulum (SR). The influx of extracellular Ca occurs primarily through voltage-gated Ca channels (VGCCs), store-operated Ca channels (SOC), and Ca release-activated channels (CRAC), whereas SR-Ca release occurs through inositol trisphosphate receptor (IPR) and ryanodine receptors (RyRs). (edu.qa)
  • whereas IP 3 signaling is conventionally initiated by receptor binding, IP 3 receptors are typically considered to be intracellular, and d - myo -IP 3 is membrane-impermeable. (aspetjournals.org)
  • INOSITOL 1,4,5-trisphosphate (Ins(l,4,5)P 3 ) serves as an intracellular second messenger for several neurotransmitters, hormones and growth factors by initiating calcium release from intracellular stores 1,2 . (elsevier.com)
  • A cerebellar Ins(l,4,5)P 3 receptor has been characterized biochemically 3,4 and shown by immunocytochemistry to be present in intracellular membranes in Purkinje cells 5 . (elsevier.com)
  • The protein encoded by this gene belongs to the inositol 1,4,5-triphosphate receptor family, whose members are second messenger intracellular calcium release channels. (genecards.org)
  • INOSITOL 1,4,5-trisphosphate (Ins (1,4,5)P 3 ), a second messenger molecule involved in actions of neurotransmitters, hormones and growth factors, releases calcium from vesicular non-mitochondrial intracellular stores 1 . (elsevier.com)
  • An Ins(1,4,5)P 3 binding protein, purified from brain membranes 2 , has been shown to be phosphorylated by cyclic-AMP-dependent protein kinase 3 and localized by immunohistochemical techniques to intracellular particles associated with the endoplasmic reticulum 4 . (elsevier.com)
  • In intact SAN preparations, IP(3)R agonists, endothelin-1 and IP(3)-butyryloxymethyl ester both increased intracellular Ca(2+) and the pacemaker firing rate, whereas the IP(3)R antagonist, 2-aminoethoxydiphenyl borate decreased Ca(2+) and the firing rate. (ox.ac.uk)
  • The ubiquitous inositol 1,4,5‐trisphosphate receptor (InsP 3 R) intracellular Ca 2+ release channel is engaged by thousands of plasma membrane receptors to generate Ca 2+ signals in all cells. (embopress.org)
  • The inositol 1,4,5-trisphosphate (IP 3 ) receptor (IP 3 R) plays key roles in increasing intracellular calcium by functioning as a channel that releases Ca 2+ from the endoplasmic reticulum. (sciencemag.org)
  • Inositol 1,4,5-trisphosphate (IP 3 ) receptors (IP 3 Rs) are tetrameric intracellular Ca 2+ -release channels with each subunit containing a binding site for IP 3 in the amino terminus. (sciencemag.org)
  • The modulation of intracellular calcium concentration [Ca 2+ ] i is a signal used by all living organisms to control many cellular processes, including gene transcription, regulated secretion, proliferation, muscle contraction, fertilization, and apoptosis ( 1 ). (sciencemag.org)
  • Ryanodine receptors (RyRs) and inositol 1,4,5-trisphosphate receptors (IP3Rs) are users of a family of tetrameric intracellular Ca2+-launch channels (CRCs). (neuroart2006.com)
  • Ryanodine receptors (RyRs) and inositol 1,4,5-trisphosphate receptors (IP3Rs) are large tetrameric intracellular Ca2+-launch channels (CRCs) located in the endo/sarcoplasmic reticulum (ER/SR) of cells. (neuroart2006.com)
  • Coupling between inositol 1,4,5-trisphosphate receptors and human transient receptor potential channel 1 when intracellular Ca2+ stores are depleted. (wikipedia.org)
  • The inositol 1,4,5-trisphosphate receptor (ITPR) is the only intracellular Ca 2+ release channel in cholangiocytes, and is therefore responsible for Ca 2+ -mediated processes in these cells. (mdpi.com)
  • Hiroshi Mori on Intracellular inositol (1,4,5)-trisphosphate receptor levels are preserved in Alzheimer's disease platelets. (alzforum.org)
  • Cellular responses to calcium (Ca 2+ ) mobilization are highly versatile due to the ability of intracellular Ca 2+ signaling to activate an extensive repertoire of downstream signaling targets [ 1 , 2 ]. (hindawi.com)
  • Although glucose-stimulated insulin release largely depends on the closure of ATP-sensitive K + channels ( 5 , 6 ), followed by voltage-activated Ca 2+ influx ( 7 ), the uptake and mobilization of the ion from intracellular stores ( 1 , 8 ) are also important for normal β-cell responses to glucose ( 9 , 10 ). (diabetesjournals.org)
  • Several hormones and neurotransmitters, including acetylcholine and ATP, bind to G-protein-coupled receptors at the cell surface and prompt the generation of intracellular inositol 1,4,5-trisphosphate (IP 3 ) ( 14 ) and increases in intracellular free Ca 2+ concentration ([Ca 2+ ] cyt ) in the β-cell ( 15 ). (diabetesjournals.org)
  • This intracellular messenger gates intracellular IP 3 receptors ( 16 ), located largely on the ER and Golgi apparatus, permitting the flow of Ca 2+ ions down a substantial concentration gradient into the cytosol. (diabetesjournals.org)
  • However, in a number of non-islet cell types, intracellular Ca 2+ stores are also accessed by Ca 2+ channels sensitive to the insecticide ryanodine (ryanodine receptors [RyRs]) ( 17 ). (diabetesjournals.org)
  • The requirement to amplify signals arising from activation of the gonadotropin-releasing hormone (GnRH) receptor and to rapidly quench the resultant signal to preserve an adaptive response suggests the need for rapid activation and feedback control operating at the level of intracellular signaling. (frontiersin.org)
  • 8 The interaction between SDF-1 and CXCR4 leads to the activation of various intracellular signaling transduction pathways and downstream effectors that mediate cell survival, proliferation, chemotaxis, migration, and adhesion. (dovepress.com)
  • The inositol trisphosphate receptor Ca2+ release ion channel A focus of the lab is the molecular physiology of intracellular signaling by Ca2+, with a particular focus on unique approaches for studying the properties and regulation of intracellular Ca2+ release channels, especially inositol trisphosphate receptors (InsP3R), and their roles in normal and pathological cell physiological states. (upenn.edu)
  • Canonical transient receptor potential channels (TRPCs) have been reported to play an important role in intracellular Ca2+ homeostasis in a number of non-excitable cells, including human platelets. (physoc.org)
  • The transduction mechanism at ORNs is mediated by cAMP and/or inositol,1,4,5-triphosphate (InsP3)-signaling pathways in an odorant-dependent manner. (sdbonline.org)
  • This study used interfering-RNAi to disrupt the level of cAMP alone or in combination with the InsP3-signaling pathway cellular targets, InsP3 receptor (InsP3R) or ryanodine receptor (RyR) in ORNs, and quantify at ORN axon terminals in the antennal lobe, the odor-induced Ca2+-response. (sdbonline.org)
  • Prolonged stimulation of rat A7r5 aortic smooth muscle cells with 3 microM vasopressin, or of hamster DDT1 MF-2 smooth muscle cells with 10 microM bradykinin or 100 microM histamine led within 4 h to a 40-50% down-regulation of the type 1 InsP3 receptor (InsP3R-1) and of the type 3 InsP3 receptor (InsP3R-3). (nih.gov)
  • This Ins(1,4,5)P3-binding protein selectively binds Ca(2+)-mobilizing inositol phosphates and other inositol phosphates which also bind to the purified InsP3 receptor, suggesting that the Ins(1,4,5)P3-binding protein of HL-60 cell membranes is the InsP3 receptor. (biochemj.org)
  • The results suggest that there is an absolute increase in the level of the InsP3 receptor during HL-60 cell differentiation and that the expression of this signal-transducing protein may be specifically regulated by differentiation factors. (biochemj.org)
  • Inositol trisphosphate receptor ( InsP3R ) is a membrane glycoprotein complex acting as a Ca 2+ channel activated by inositol trisphosphate (InsP3). (wikipedia.org)
  • The InsP3 receptor was first purified from rat cerebellum by neuroscientists Surachai Supattapone and Solomon Snyder at Johns Hopkins University School of Medicine. (wikipedia.org)
  • The cDNA of the InsP3 receptor was first cloned in the laboratory of Katsuhiko Mikoshiba. (wikipedia.org)
  • It is additionally the means for further InsP3 receptor diversity in that it has as many as four splice sites with as many as 9 different optional exons or exon variants. (wikipedia.org)
  • Accordingly, InsP3 receptors expressed in the decapsulated tissue are of medullary origin. (scienceexchange.com)
  • abstract = "The inositol 1,4,5-trisphosphate receptor (InsP3R) is activated by InsP3 binding to amino-terminal ligand binding domain (InsP3R-N). Recently we reported functional coupling of phosphatidylinositol (4,5)-bisphosphate (PIP2) to the InsP3R. (elsevier.com)
  • The subcellular localization of inositol 1,4,5-trisphosphate (InsP3)-induced Ca2+ signals is important for the activation of many physiological functions. (mendeley.com)
  • In epithelial cells the spatial distribution of InsP3 receptor is restricted to specific areas, but little is known about the relationship between the receptor's distribution and cell polarity. (mendeley.com)
  • This cell line is characterized by a strong expression of the type 3 InsP3 receptor and the subcellular localization of this receptor was followed during cell polarization using immunofluorescence and confocal analysis. (mendeley.com)
  • In non-polarized cells, including ras transformed f3 MDCK cells, the type 3 InsP3 receptor was found to co-localize with markers of the endoplasmic reticulum in the cytoplasm. (mendeley.com)
  • The localization of the type 3 InsP3 receptor in the vicinity of tight junctions was confirmed by immunogold electron microscopy. (mendeley.com)
  • MDCK cells were stably transfected with a plasmid coding the full-length mouse type 1 InsP3 receptor tagged with EGFP at the C-terminus. (mendeley.com)
  • Thus, the localization of InsP3 receptor in MDCK depends on polarity. (mendeley.com)
  • 1] "Structure of a novel InsP3 receptor. (tcdb.org)
  • Inositol 1,4,5-trisphosphate receptors (IP3R) are Ca2+ channels on the neuronal endoplasmic reticulum (ER) membrane. (sdbonline.org)
  • We now report that calcineurin is physiologically associated with the IP3R-FKBP12 and RyR-FKBP12 receptor complexes and that this interaction can be disrupted by FK506 or rapamycin. (nih.gov)
  • Calcineurin anchored to the IP3R via FKBP12 regulates the phosphorylation status of the receptor, resulting in a dynamic Ca(2+)-sensitive regulation of IP3-mediated Ca2+ flux. (nih.gov)
  • In mouse eggs, these oscillations cease after a variable period of time and this is accompanied by a decrease in inositol 1,4,5-trisphosphate receptor (IP3R) responsiveness and down-regulation of the IP3R type 1 (IP3R-1). (nih.gov)
  • To investigate the signaling pathway responsible for inducing IP3R-1 down-regulation during fertilization, mouse eggs were exposed to or injected with several Ca(2+)-releasing agonists and the amounts of IP3R-1 immunoreactivity evaluated by Western blotting. (nih.gov)
  • Exposure to ethanol or ionomycin, which induce a single [Ca(2+)]i rise, failed to signal down-regulation of IP3R-1. (nih.gov)
  • However, [Ca(2+)]i oscillations induced by injection of boar sperm fractions (SF), which presumably stimulate production of IP3, or adenophostin A, an IP3R agonist, both induced down-regulation of IP3R-1 of a magnitude similar to or greater than that observed after fertilization. (nih.gov)
  • Exposure to thimerosal, an oxidizing agent that modifies the IP3R without stimulating production of IP3, also initiated down-regulation of IP3R-1, although oscillations initiated by SrCl(2) failed to evoke down-regulation of IP3R-1. (nih.gov)
  • The degradation of IP3R-1 in mouse eggs appears to be mediated by the proteasome pathway because it was inhibited by preincubation with lactacystin, a very specific proteasome inhibitor. (nih.gov)
  • We therefore suggest that persistent stimulation of the phosphoinositide pathway in mouse eggs by the sperm during fertilization or by injection of SF leads to down-regulation of the IP3R-1. (nih.gov)
  • Western blotting using a polyclonal antibody directed against purified brain IP3 receptor (IP3R) identified a specific 260 kD band in 1% Triton X-100 extracts of rat, hamster, mouse and dog sperm. (rupress.org)
  • The presence of G alpha q/11, PLC beta 1 and a functional IP3R in the anterior acrosomal region of mammalian sperm, as well as thapsigargin's induction of the acrosome reaction, implicate IP3-gated calcium release in the mammalian acrosome reaction. (rupress.org)
  • Because the ion conduction pore composes only ∼5% of the IP3R, the great bulk of this large protein contains recognition sites for these substances. (elsevier.com)
  • Sustained Ca2+ entry requires endoplasmic reticulum (ER) Ca2+ depletion and prolonged activation of inositol 1,4,5-trisphosphate receptor (IP3R)/Ca2+ release channels. (elsevier.com)
  • In this study, we examined tear secretion in mice lacking the inositol 1,4,5-trisphosphate receptor (IP3R) types 2 and 3 (Itpr2 -/-;Itpr3-/-double-knockout mice). (elsevier.com)
  • Thus, the Gαq-protein-coupled receptor/IP3R effector pathway offers inotropic reserve, which is hindered by electric instability and contractile abnormalities. (ahajournals.org)
  • abstract = "The inositol 1,4,5-trisphosphate receptor (IP3R) is a major regulator of apoptotic signaling. (elsevier.com)
  • Phylogenetic analyses were consistent with these proteins representing RyR and IP3R homologues, respectively (Fig. 1). (neuroart2006.com)
  • Number 1 Phylogenetic tree of the RyR and IP3R family members. (neuroart2006.com)
  • Tyr-167/Trp-168 in type 1/3 inositol 1,4,5-trisphosphate receptor mediates functional coupling between ligand binding and channel opening. (ebi.ac.uk)
  • Structural studies of inositol 1,4,5-trisphosphate receptor: coupling ligand binding to channel gating. (ebi.ac.uk)
  • We compared the Ins(1,4,5)P3-binding sites of liver and cerebellum by measuring inhibition of specific Ins(1,4,[32P]5)P3 binding by various ligands under equilibrium conditions, and find that each ligand binds with similar affinity in the two tissues. (biochemj.org)
  • The receptor contains a calcium channel at the C-terminus and the ligand-binding site at the N-terminus. (sigmaaldrich.com)
  • Inositol 1,4,5-trisphosphate (IP3) receptors are a form of ligand-gated ion channels that are activated by cytosolic Ca2+ and IP3. (genecards.org)
  • Inositol 1,4,5-trisphosphate (IP 3 ) receptors (IP 3 Rs) are ligand-gated calcium channels present in most eukaryotic species ( 1 - 3 ). (sciencemag.org)
  • Xestospongin B- or starvation-induced autophagy was inhibited by overexpression of the IP 3 R ligand-binding domain, which coimmunoprecipitated with Beclin 1. (elsevier.com)
  • The inositol 1,4,5-trisphosphate receptor (InsP 3 R) is activated by InsP 3 binding to amino-terminal ligand binding domain (InsP 3 R-N). Recently we reported functional coupling of phosphatidylinositol (4,5)-bisphosphate (PIP 2 ) to the InsP 3 R. Specific binding of PIP 2 to InsP 3 R-N domain was postulated as a part of the InsP 3 R-PIP 2 functional coupling model. (elsevier.com)
  • Fingerprint Dive into the research topics of 'Association of the inositol (1,4,5)-trisphosphate receptor ligand binding site with phosphatidylinositol (4,5)-bisphosphate and Adenophostin A'. Together they form a unique fingerprint. (elsevier.com)
  • Association of the inositol (1,4,5)-trisphosphate receptor ligand binding site with phosphatidylinositol (4,5)-bisphosphate and Adenophostin A . Molecular Cell Biology Research Communications , 3 (3), 153-158. (elsevier.com)
  • Glouchankova L, Krishna UM, Potter BVL , Falck JR , Bezprozvanny I . Association of the inositol (1,4,5)-trisphosphate receptor ligand binding site with phosphatidylinositol (4,5)-bisphosphate and Adenophostin A . Molecular Cell Biology Research Communications . (elsevier.com)
  • It is estimated that more than half of all drugs in clinical use target GPCRs, acting either to mimic endogenous GPCR ligands, to block ligand access to the receptor, or to modulate ligand production [ 1 ]. (mdpi.com)
  • Among the mini-series, compound 28 ( K i σ1 = 0.2 nM, K i σ2 = 198 nM, CNS MPO score = 5.4) emerged as a promising selective σ1 receptor ligand that warrants its further evaluation as a potential therapeutic for neurodegenerative diseases. (rsc.org)
  • Pentazocine ( 1 ) is a classical σ1 receptor ligand, capable of enhancing the neurite outgrowth in PC-12 cellular model caused by the activation of σ1 receptor and this activity was antagonized by NE-100 ( 2 ), a σ1 receptor antagonist. (rsc.org)
  • This interaction allows the binding of the collagen receptor GPVI to its ligand and to initiate cellular activation, a process that is reinforced by locally produced thrombin and soluble mediators released from platelets. (ahajournals.org)
  • Extracellular ligand stimulation of these receptors activates a PI-specific phospholipase C (PLC). (royalsocietypublishing.org)
  • Lowering [K + ] of the medium decreased the sensitivity of NAADP receptors for their ligand in stimulating Ca 2+ release, but it did not affect inactivation of NAADP-induced Ca 2+ release by subthreshold concentrations of NAADP. (portlandpress.com)
  • InsP3R down-regulation was a cell- and agonist-specific process, since several other agonists acting on PLC-coupled receptors did not change the expression level of the InsP3R isoforms in these cell types and since no agonist-induced down-regulation of InsP3Rs was observed in HeLa cells. (nih.gov)
  • The Ca2+ channel blocker verapamil (2 microM) also induced InsP3R-1 down-regulation (43%) in A7r5 cells, which was inhibited by ALLN. (nih.gov)
  • In A7r5 cells transiently transfected with a cDNA construct, bearing a luciferase coding sequence under control of the rat InsP3R-1 promoter, reduced luciferase activity could be demonstrated upon stimulation of cells with vasopressin or verapamil. (nih.gov)
  • InsP3R-1 is the most widely expressed of these three and is found in all tissue types and all developmental stages of life. (wikipedia.org)
  • Now we have examined the expression of different subtypes of inositol 1,4,5-trisphosphate receptor (InsP3R) in the inner zones of rat adrenal cortex. (scienceexchange.com)
  • InsP3R-associated cGMP kinase substrate determines inositol 1,4,5-trisphosphate receptor susceptibility to phosphoregulation by cyclic nucleotide-dependent kinases. (springer.com)
  • The target protein for InsP 3 binding was later identified as the inositol 1,4,5-trisphosphate receptor (InsP 3 R) ( 56 ). (pancreapedia.org)
  • Pancreatic acinar cells are highly polarized, both functionally and morphologically and InsP 3 Rs are predominantly expressed in ER extensions in the apical regions juxtaposed to the acinar lumen ( Figure 1 ) ( 34 , 36 , 42 , 69 ). (pancreapedia.org)
  • Stimulation of basal secretagogue receptors as well as uncaging InsP 3 in various regions of the cell also confirm that Ca 2+ signals initiate in apical regions of the pancreatic acinar cell ( 5 , 20 , 31 , 58 , 65 ). (pancreapedia.org)
  • Inositol-1,4,5-trisphosphate (InsP 3 ) is a diffusible messenger formed within the cell in response to external stimuli. (springer.com)
  • The syntheses of four D-myo-inositol 1,4,5-trisphosphate (InsP(3)) derivatives, incorporating phosphate bioisosteres at the 5-position, are reported. (ox.ac.uk)
  • Here we utilized bacterially expressed and purified InsP 3 R-N domain to characterize its binding specificity for InsP 3 , Adenophostin A (AdA) and the water, soluble PIP 2 analog dioctanoyl-(4,5)PIP 2 (ShPIP 2 ). (elsevier.com)
  • Stimulation of receptors coupled to G q/11 -proteins results in activation of phospholipase C (PLC). (jneurosci.org)
  • These proteins mediate a rise in cytoplasmic calcium in response to receptor activated production of inositol triphosphate. (genecards.org)
  • Also, it is unclear whether a single protein mediates both the recognition of Ins(1,4,5)P 3 and calcium transport or whether these two functions involve two or more distinct proteins. (elsevier.com)
  • Analysis of these concatenated receptor proteins revealed that channel activity required IP 3 bound to each of the four binding sites, which ensures that cells do not discharge calcium unless the signal to do so is strong enough. (sciencemag.org)
  • None of these putative sour receptor proteins are shown to be localized at the taste pore region, where tastants are likely to be detected. (pnas.org)
  • Evidence that type I, II, and III inositol 1,4,5-trisphosphate receptors can occur as integral plasma membrane proteins. (wikipedia.org)
  • βarrestin (βarr)-1 and -2 (βarrs) (or Arrestin-2 and -3, respectively) are universal G protein-coupled receptor (GPCR) adapter proteins expressed abundantly in extra-retinal tissues, including the myocardium. (mdpi.com)
  • Ca 2+ release is also isomer specific, with other structurally related inositol phosphates shown to be far less efficacious in releasing Ca 2+ ( 54 ). (pancreapedia.org)
  • Although the specificity of the Ins(1,4,5)P 3 binding protein for inositol phosphates and the high affinity of the protein for Ins(1,4,5)P 3 indicate that it is a physiological Ins(1,4,5)P 3 receptor mediating calcium release, direct evidence for this has been difficult to obtain. (elsevier.com)
  • We show that Ins(1,4,5)P 3 and other inositol phosphates stimulate calcium flux in the reconstituted vesicles with potencies and specificities that match the calcium releasing actions of Ins(1,4,5)P 3 . (elsevier.com)
  • Activation of adenylyl cyclase by forskolin or by isoproterenol caused increased phosphorylation of phospholipase C-β 2 isoform and reduced the formation of inositol phosphates after ACh stimulation of muscarinic receptors. (aspetjournals.org)
  • We have characterized inositol 1,4,5-trisphosphate (IP3)-gated calcium channels and upstream components of the phosphoinositide signaling system in mammalian sperm. (rupress.org)
  • Emerging roles of inositol 1,4,5-trisphosphate signaling in cardiac myocytes. (semanticscholar.org)
  • Depolarization has a bidirectional effect on G q PCR signaling, potentiating thapsigargin-sensitive Ca 2+ responses to muscarinic receptor activation but attenuating those mediated by bradykinin receptors. (jneurosci.org)
  • Flash photolysis of caged IP 3 /GPIP 2 (glycerophosphoryl- myo -inositol 4,5-bisphosphate) places the voltage sensor before the level of the Ca 2+ store, and measurements using the fluorescent bioprobe eGFP-PH PLCδ (enhanced green fluorescent protein-pleckstrin homology domain-PLCδ) directly demonstrate that voltage affects muscarinic signaling at the level of the IP 3 production pathway. (jneurosci.org)
  • The sensitivity of G q PCR IP 3 signaling in neurons to voltage itself may represent a fundamental mechanism by which ionotropic signals can shape metabotropic receptor activity in neurons and influence processes such as synaptic plasticity in which the detection of coincident signals is crucial. (jneurosci.org)
  • 2018). Integrins, a grouped category of 24 heterodimers comprising and subunits, are transmembrane adhesion receptors that are fundamental the different parts of cell signaling systems involved in cancers development and metastasis (Hynes, 2002). (healthyconnectionsinc.com)
  • Inositol triphosphate receptor-mediated signaling is involved in many processes includin. (genecards.org)
  • Inositol triphosphate receptor-mediated signaling is involved in many processes including cell migration, cell division, smooth muscle contraction, and neuronal signaling. (genecards.org)
  • Among its related pathways are Downstream signaling events of B Cell Receptor (BCR) and Signaling by GPCR . (genecards.org)
  • RATIONALE: Inositol 1,4,5-trisphosphate receptors (IP(3)Rs) have been implicated in the generation of arrhythmias and cardiac muscle nuclear signaling. (ox.ac.uk)
  • The inositol 1,4,5-trisphosphate receptor (IP 3 R) is a major regulator of apoptotic signaling. (elsevier.com)
  • Both were discovered in the lab of the 2012 Nobel Prize in Chemistry co-laureate Robert Lefkowitz, initially as terminators of signaling from the β-adrenergic receptor (βAR), a process known as functional desensitization. (mdpi.com)
  • They are now known to switch GPCR signaling from G protein-dependent to G protein-independent, which, in the case of βARs and angiotensin II type 1 receptor (AT 1 R), might be beneficial, e.g., anti-apoptotic, for the heart. (mdpi.com)
  • The present review will discuss the current knowledge in the field of βarrs and their roles in GPCR signaling and function in the heart, focusing on the three most important, for cardiac physiology, GPCR types (β 1 AR, β 2 AR & AT 1 R), and will also highlight important questions that currently remain unanswered. (mdpi.com)
  • During the past decades, various kinds of receptors, ion channels and signaling pathways associated with neurogenesis activities have been identified as potential therapeutic targets for neurodegenerative diseases. (rsc.org)
  • 10 The literature reports to date indicate that σ1 receptor is considered as chaperonin to modulate signaling pathways of ER-mitochondrion such as Ca 2+ , K + , and NMDA and IP 3 receptors, playing an important role in healthy CNS functioning. (rsc.org)
  • 1999 ). IRAG forms a complex with the inositol 1,4,5-trisphosphate receptor (IP 3 R) and cGMP kinase I-β (cGKIβ) and is involved in nitric oxide (NO), cGMP, and cGKIβ signaling pathways. (springer.com)
  • In this article we will first briefly review TRPC3 and IP 3 R signaling that relate to store/receptor-operated Ca 2+ entry (SOCE/ROCE) mechanisms and cardiac arrhythmias. (frontiersin.org)
  • We also show that pacemaker cells express TRPC3 and several other molecular components related to SOCE/ROCE signaling, including STIM1 and IP 3 R. Activation of G-protein coupled receptors (GPCRs) signaling that is able to modulate SOCE/ROCE and Ang II induced Ca 2+ homeostasis changes in sinoatrial complex being linked to TRPC3. (frontiersin.org)
  • Emerging data suggest that reactive oxygen species (ROS) can fulfill this role in the GnRH receptor signaling through activation of MAP kinase signaling cascades, control of negative feedback, and participation in the secretory process. (frontiersin.org)
  • The identity of the signaling molecules and mechanisms that contribute to pulse interpretation has been the subject of extensive study since many models developed to explain signaling control of gene expression ( 4 - 13 ). (frontiersin.org)
  • An Ins(1,4,5)P3 receptor from cerebellum has been purified and functionally reconstituted, but the relationship between this protein and the high-affinity Ins(1,4,5)P3-binding sites of peripheral tissues is unclear. (biochemj.org)
  • We conclude that the high-affinity Ins(1,4,5)P3-binding site of hepatocytes is likely to be the receptor that mediates Ca2+ mobilization, and that this receptor is at present indistinguishable from that in cerebellum. (biochemj.org)
  • The receptor has a broad tissue distribution but is especially abundant in the cerebellum . (wikipedia.org)
  • After the injection of KA in a convulsive dose (10 mg/kg i.p.), inositol 1,4,5-trisphosphate receptor mRNA was reduced significantly in dentate gyrus , cerebral cortex , and caudate- putamen and moderately in CA1-CA3 areas of hippocampus and cerebellum . (bvsalud.org)
  • The significant repression of inositol 1,4,5-trisphosphate receptor mRNA in cerebellum was only found at 9 h after KA injection . (bvsalud.org)
  • abstract = "The inositol 1,4,5-trisphosphate (IP3) receptor (IP 3R) Ca2+ channel plays pivotal roles in many aspects of physiological and pathological events. (elsevier.com)
  • These results suggest that adenosine receptor activation in porcine coronary artery inhibits agonist-induced production of IP 3 , and the magnitude of inhibition appears to depend on the type of adenosine analog used and on the presence and absence of endothelium. (elsevier.com)
  • The Phospholipase C inhibitor neomycin equally inhibits responses to the two peptides while 5-HT responses are unaffected. (lancs.ac.uk)
  • CCK - Suppresses motility in the stomach and duodenum [4] Additionally, CCK stimulates secretion of PPY and inhibits the secretion of ghrelin. (wikipedia.org)
  • We also observed a defect of the increase in BDNF production after AMPA receptor (AMPAR) and metabotropic glutamate receptor (mGluR) stimulation in IP 3 R1KO cerebellar granule cells, and that exogenous application of BDNF rescued the abnormal morphology of IP 3 R1KO Purkinje cells. (jneurosci.org)
  • Upon stimulation by inositol 1,4,5-trisphosphate, this receptor mediates calcium release from the endoplasmic reticulum. (nih.gov)
  • The fundamental role of pulsatile stimulation of gonadotropes by the hypothalamic neuropeptide GnRH, or GnRH-I in maintaining function of the hypothalamic-pituitary-gonad (HPG) axis is one of the earliest principal findings after discovery of the hormone ( 1 , 2 ). (frontiersin.org)
  • Cholinergic stimulation with acetylcholine (ACh), by contrast, caused a rapid increase in phosphatidylethanol followed by a slow decline in the concentration of phosphatidylethanol from 5 to 20 min in the continued presence of ACh. (aspetjournals.org)
  • We conclude that phosphorylated disaccharides provide novel means of developing high-affinity ligands of Ins(1,4,5)P3 receptors. (ox.ac.uk)
  • In vitro binding studies of these compounds demonstrated their low nanomolar to subnanomolar potencies as σ1 receptor ligands, with moderate to excellent selectivity over the σ2 receptor as represented by compounds 17-30 . (rsc.org)
  • 8,9 In 2016, the crystal structure of the human σ1 receptor was reported in complex with two divergent ligands. (rsc.org)
  • 11-13 In particular, neurogenesis efficacy of brain penetrant σ1 receptor ligands is of a considerable interest, which has been attributed to the σ1 receptor's role in the modulation of cellular trafficking. (rsc.org)
  • An increasing number of σ1 receptor ligands that stimulate neurite outgrowth in cellular screening models have been reported to date. (rsc.org)
  • 2] "Identification of a family of calcium sensors as protein ligands of inositol trisphosphate receptor Ca(2+) release channels. (tcdb.org)
  • Activated PLC converts membrane-bound phosphatidylinositol (4,5)-bisphosphate (PIP 2 ) into IP 3 and lipophilic diacylglycerol (DAG). (royalsocietypublishing.org)
  • The G protein-coupled receptors (GPCRs) or heptahelical or seven-transmembrane spanning receptors are by far the largest and most diverse superfamily of cell surface receptors. (mdpi.com)
  • Approximately 600 distinct genes encoding non-olfactory GPCRs make up greater than 1% of the human genome [ 1 ]. (mdpi.com)
  • 2 , 3 Chemokine receptors are a family of G protein-coupled cell surface receptors (GPCRs) with seven transmembrane-spanning domains. (dovepress.com)
  • Agonist-induced down-regulation of type 1 and type 3 inositol 1,4,5-trisphosphate receptors in A7r5 and DDT1 MF-2 smooth muscle cells. (nih.gov)
  • Down-regulation of the inositol 1,4,5-trisphosphate receptor in mouse eggs following fertilization or parthenogenetic activation. (nih.gov)
  • The role of the paracrine/autocrine mediator endothelin-1 in regulation of cardiac contractility and growth. (semanticscholar.org)
  • Regulation of hair shedding by the type 3 IP3 receptor. (semanticscholar.org)
  • Regulation of mouse egg activation: presence of ryanodine receptors and effects of microinjected ryanodine and cyclic ADP ribose on uninseminated and inseminated eggs. (semanticscholar.org)
  • Regulation of calcium spiking in mammalian oocytes through a combination of inositol trisphosphate-dependent entry and release. (semanticscholar.org)
  • Selective down-regulation of IP(3)receptor subtypes by caspases and calpain during TNF alpha -induced apoptosis of human T-lymphoma cells. (wikipedia.org)
  • However, the molecular mechanisms involved in both the uptake and release of Ca 2+ from the ER are only partially defined in these cells, and the presence and regulation of ER ryanodine receptors are a matter of particular controversy. (diabetesjournals.org)
  • Schild analysis of inhibition of Ins(1,4,5)P3 binding by ATP demonstrates a competitive interaction between the two at the liver Ins(1,4,5)P3-binding site, and this partly accounts for earlier discrepancies in binding and Ca2(+)-release data. (biochemj.org)
  • Enhances Ca(2+)-mediated inhibition of inositol 1,4,5-triphosphate receptor (ITPR) Ca(2+) release. (mybiosource.com)
  • Previously, we indirectly showed that relaxation of porcine coronary artery by adenosine and its analogs are linked to modulation of phospholipase C and protein kinase C. In the present investigation, we assessed if the relaxant responses to the adenosine analogs CAD and NECA are associated with inhibition of inositol 1,4,5-trisphosphate (IP 3 ) formation. (elsevier.com)
  • PPY - inhibition of upper GI tract motility GLP-1 - Functions as an "Ileal Brake" to inhibit upper GI tract motility when the distal gut is exposed to unabsorbed nutrients. (wikipedia.org)
  • Molecular cloning of mouse type 2 and type 3 inositol 1,4,5-trisphosphate receptors and identification of a novel type 2 receptor splice variant. (semanticscholar.org)
  • [5] The large size of this open reading frame indicated a molecular weight similar to the protein purified biochemically, and soon thereafter it was confirmed that the protein p400 was in fact the inositol trisphosphate receptor . (wikipedia.org)
  • We show that a previously described Purkinje-cell messenger RNA 6 encodes a protein of relative molecular mass 260,000 (260 K) with the same properties as the cerebellar Ins(l,4,5)P 3 receptor. (elsevier.com)
  • Here, we show that the IP 3 R antagonist xestospongin B induces autophagy by disrupting a molecular complex formed by the IP 3 R and Beclin 1, an interaction that is increased or inhibited by overexpression or knockdown of Bcl-2, respectively. (elsevier.com)
  • Although characterization of molecular identities that receive taste chemicals is essential, molecular receptors underlying sour taste sensation remain unclear. (pnas.org)
  • Much progress has been made in unraveling the molecular mechanisms of bitter, sweet, and umami taste in recent years ( 2 - 5 ). (pnas.org)
  • Ammendola A, Geiselhöringer A, Hofmann F, Schlossmann J. Molecular determinants of the interaction between the inositol 1, 4,5-trisphosphate receptor associated cGMP kinase substrate (IRAG) and cGMP kinase Ibeta. (springer.com)
  • The molecular targets of STIM1 in these cells likely involve Orai channels and canonical transient receptor potential (TRPC) channels TRPC1 and TRPC3. (springer.com)
  • For about 20 years after the initial concept of store-operated Ca 2+ entry (SOCE) was proposed by Putney [ 1 , 2 ], the molecular candidates underpinning SOCE remained elusive. (springer.com)
  • ITPR2 (do inglês, inositol 1,4,5-triphosphate receptor, type 2 ) é uma proteína que é codificado pelo gene humano ITPR2 . (wikipedia.org)
  • Goutsouliak, V. and Rabkin, S.W. Angiotensin II-induced inositol phosphate generation is mediated through tyrosine kinase pathways in cardiomyocytes. (biomedcentral.com)
  • Inositol 1,4,5-trisphosphate (IP 3 ) receptor-associated cyclic GMP (cGMP) kinase substrate (IRAG) is a 125-kD type 2 integral endoplasmic reticulum (ER) membrane protein. (springer.com)
  • In this study, we show that actin dynamics in spines is regulated by a Rac anchoring and targeting function of inositol 1,4,5-trisphosphate 3-kinase A (IP 3 K-A), independent of its kinase activity. (pubmedcentralcanada.ca)
  • Two predominant receptor classes are the G-protein-coupled receptor class and the receptor tyrosine kinase class. (royalsocietypublishing.org)
  • These slow imaginal disc intercellular calcium waves (SIDICs) are mediated by the inositol-3-phosphate receptor , the endoplasmic reticulum (ER) calcium pump SERCA and the key gap junction component Inx2 . (sdbonline.org)
  • To study whether sarcoplasmic/endoplasmic reticulum Ca 2+ -ATPase (SERCA)-type Ca 2+ -ATPases are responsible for Ca 2+ uptake into Ins(1,4,5) P 3 -sensitive Ca 2+ stores, we used the three structurally unrelated inhibitors thapsigargin, 2,5-di-t-butylhydroquinone and cyclopiazonic acid. (portlandpress.com)
  • HL-60 cell membranes enriched in marker enzyme activities of the endoplasmic reticulum and the plasma membrane possess a high-affinity binding site for [3H]Ins(1,4,5)P3 (KD = 22 nM). (biochemj.org)
  • Sustained Ca 2+ entry requires endoplasmic reticulum (ER) Ca 2+ depletion and prolonged activation of inositol 1,4,5-trisphosphate receptor (IP 3 R)/Ca 2+ release channels. (elsevier.com)
  • The authors hypothesized that isoflurane activates inositol 1,4,5-trisphosphate (IP3) receptors on the endoplasmic reticulum (ER) membrane, causing excessive calcium release, triggering apoptosis. (asahq.org)
  • 7 The σ1 receptor has been cloned and encoded as a protein of 223 amino acids, and specifically localized at the mitochondrial-associated endoplasmic reticulum membrane. (rsc.org)
  • Isoflurane induced significantly more neurotoxicity and greater calcium release from the ER in L286V PC12 and Q111 Huntingtin striatal cells than in their corresponding wild-type controls, both of which were significantly inhibited by the IP3 receptor antagonist xestospongin C. (asahq.org)
  • Lin MJ, Leung GP, Zhang WM, Yang XR, Yip KP, Tse CM, Sham JS (2004) Chronic hypoxia-induced upregulation of store-operated and receptor-operated Ca 2+ channels in pulmonary arterial smooth muscle cells: a novel mechanism of hypoxic pulmonary hypertension. (springer.com)
  • In this study, we have analysed the relationship between Ca 2+ pumps and Ins(1,4,5) P 3 -sensitive Ca 2+ channels in myeloid cells. (portlandpress.com)
  • Receptors Channels 1 (1993) 11-24. (biomedcentral.com)
  • The inositol 1,4,5-trisphosphate receptors (IP3Rs) as ligandgated Ca 2+ channels are key modulators of cellular processes. (elsevier.com)
  • HCN1 and HCN4, members of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels, also are putative sour receptor channels ( 9 ). (pnas.org)
  • Some TRP channels, such as TRPV1, function directly as receptors for stimuli (high temperature and capsaicin) by themselves, whereas other TRP channels, such as TRP-melastatin 5 (TRPM5), are downstream effectors of G protein-coupled sensory receptors ( 13 - 15 ). (pnas.org)
  • Activation of store-mediated calcium entry by secretion-like coupling between the inositol 1,4,5-trisphosphate receptor type II and human transient receptor potential (hTrp1) channels in human platelets. (wikipedia.org)
  • Recent evidence suggests that Ca 2+ entry through TRPC3 (Transient Receptor Potential Canonical-3) channels may underlie several pathophysiological conditions -including cardiac arrhythmias. (frontiersin.org)
  • Electrotransfer studies indicate that Ins(1,4,[32P]5)P3 binds specifically to a 260 kDa protein of HL-60 cell membranes. (biochemj.org)
  • We show that IP 3 R1 binds to the scaffolding protein linker of activated T cells and colocalizes with the T cell receptor during activation, resulting in persistent phosphorylation of IP 3 R1 at Tyr353. (elsevier.com)
  • This protein is a type 2 receptor that consists of a cytoplasmic amino-terminus that binds inositol triphosphate, six membrane-spanning helices that contribute to the ion pore, and a short cytoplasmic carboxy-terminus. (genecards.org)
  • 4 , 5 The chemokine receptor CXCR4 is a 352-amino acid rhodopsin-like GPCR that selectively binds to the CXC chemokine SDF-1 or CXCL12. (dovepress.com)
  • IP 3 subsequently binds to receptors (IP 3 R) located principally on the ER triggering the rapid release of Ca 2+ into the cytosol of the cell. (royalsocietypublishing.org)
  • TRPCs contain a conserved calmodulin (CaM)/inositol 1,4,5-trisphosphate (IP3) receptor-binding (CIRB) site in the cytosolic C-terminal region, which binds both IP3 receptor and CaM. (physoc.org)
  • In this study we found that the time course of clustering of green fluorescent protein-tagged IP 3 R type 1 (GFP-IP 3 R1), evoked by IP 3 -generating agonists, did not correlate with [Ca 2+ ] C but seemed compatible with cytoplasmic IP 3 concentration. (elsevier.com)
  • Results cDNA Cloning and characterization of and in A total of 12 and 6 overlapping cDNA fragments were acquired for respectively (Table 1). (neuroart2006.com)
  • 2001). «Alternative splice variants of hTrp4 differentially interact with the C-terminal portion of the inositol 1,4,5-trisphosphate receptors. (wikipedia.org)
  • Kim, J.C., Son, M.J., Subedi, K.P., Kim, D.H. and Woo, S.H. IP 3 -induced cytosolic and nuclear Ca 2+ signals in HL-1 atrial myocytes: possible role of IP 3 receptor subtypes. (biomedcentral.com)
  • Demonstrating the likely presence of ryanodine receptors (RyRs), caffeine and 4-chloro-3-ethylphenol both caused an almost complete emptying of ER Ca 2+ and marked increases in [Ca 2+ ] cyt . (diabetesjournals.org)
  • Indirect immunofluorescence labeling showed type I inositol 1,4,5-trisphosphate receptors (IP 3 R) in the acrosome and neck region, but no ryanodine receptors (RyR) were found using anti-RyR antibodies or BODIPY FL-X ryanodine. (bioone.org)
  • Type 1 IP 3 R (IP 3 R1) is enriched in growth cones of neurons in chick dorsal root ganglia. (sciencemag.org)
  • Here, we show that cultured Purkinje cells from inositol 1,4,5-trisphosphate receptor type 1 knock-out (IP 3 R1KO) mice exhibited abnormal dendritic morphology. (jneurosci.org)
  • Immunoblotting with subtype-directed antibodies demonstrated that HL-60 cells contain the Ca 2+ pump SERCA2 (subtype b), and the Ca 2+ -release-channel type-1 Ins(1,4,5) P 3 receptor. (portlandpress.com)
  • In subcellular fractionation studies, SERCA2 and type-1 Ins(1,4,5) P 3 receptor co-purified. (portlandpress.com)
  • Immunofluorescence studies demonstrated that both type-1 Ins(1,4,5) P 3 receptor and SERCA2 were evenly distributed throughout the cell in moving neutrophils. (portlandpress.com)
  • Taken together, our results suggest that in myeloid cells (i) SERCA-type Ca 2+ -ATPases function as Ca 2+ pumps of Ins(1,4,5) P 3 -sensitive Ca 2+ stores, and (ii) SERCA2 and type-1 Ins(1,4,5) P 3 receptor reside either in the same or two tightly associated subcellular compartments. (portlandpress.com)
  • Type 1 and 3 inositol trisphosphate receptors are required for extra-embryonic vascular development. (semanticscholar.org)
  • Recently, we described a novel autoantibody, anti-Sj/ITPR1-IgG, that targets the inositol 1,4,5-trisphosphate receptor type 1 (ITPR1) in patients with cerebellar ataxia. (biomedcentral.com)
  • Knockout studies in mice suggest that type 2 and type 3 inositol 1,4,5-trisphosphate receptors play a key role in exocrine secretion underlying energy metabolism and growth. (sigmaaldrich.com)
  • ITPR2 (Inositol 1,4,5-Trisphosphate Receptor Type 2) is a Protein Coding gene. (genecards.org)
  • The glyconucleotides adenophostin A and B are the most potent known agonists at type 1 inositol trisphosphate [Ins(1,4,5)P3] receptors, although their stuctures differ markedly from that of Ins(1,4,5)P3. (ox.ac.uk)
  • Equilibrium competition binding with [3H]Ins(1,4,5)P3 and unidirectional 45Ca2+ flux measurements were used to examine the effects of adenophostin A in hepatocytes, which express predominantly type 2 Ins(1,4,5)P3 receptors. (ox.ac.uk)
  • The authors used the chicken B lymphocyte with a total knock-out of IP3 receptors, PC12 cells with elevated IP3 receptor activity (transfected with L286V presenilin 1), striatal cells with a knock-in of Q111 Huntingtin, and each cell line's corresponding wild-type controls. (asahq.org)
  • Isoflurane induced apoptosis concentration- and time-dependently, and sequentially elevated cytosolic and then mitochondrial calcium in the chicken B-lymphocyte wild-type but not the IP3 receptor total knock-out cells. (asahq.org)
  • Thapsigargin, a calcium adenosine triphosphatase inhibitor on ER membranes, induced apoptosis and elevations of calcium in cytosol and mitochondria in both chicken B-lymphocyte wild-type and IP3 receptor total knock-out cells. (asahq.org)
  • Inositol 1,4,5-trisphosphate receptor type 1 (IP 3 R1) is already known to be highly expressed in the brain, and is found in many other tissues, including the atrium of the heart. (biomedcentral.com)
  • Functional relevance of the de novo coupling between hTRPC1 and type II IP3 receptor in store-operated Ca2+ entry in human platelets. (wikipedia.org)
  • Multiple neural autoantibodies are associated with autonomic disorders (ganglionic nicotinic acetylcholine receptor antibody, ANNA-1, P/Q and N-type VGCCs, NMDA, CASPR2, DPPX). (medscape.com)
  • The type 3 inositol 1,4,5-trispho. (mendeley.com)
  • The EGFP-tagged type 1 receptor and the endogenous type 3 co-localized in the cytoplasm of non-polarized cells and at the tight junction level of polarized cells. (mendeley.com)
  • C-X-C chemokine receptor type 4 (CXCR4), also known as fusin or CD184, is an alpha-chemokine receptor specific for stromal-derived-factor-1 (SDF-1 also called CXCL12). (dovepress.com)
  • After Gαq-protein-coupled receptor activation, the Ca 2+ mobilized from the sarcoplasmic reticulum by IP3Rs contributes to the decrease in resting membrane potential, prolongation of the action potential, and incidence of early afterdepolarizations. (ahajournals.org)
  • While the IP3Rs are approximately half the size of the RyRs, these two receptors show similarities in their rules, and a recent study indicated that RyRs and IP3Rs have co-evolved from an ancestral unicellular RyR/IP3R1. (neuroart2006.com)
  • The physical contractions of the smooth muscle cells can be caused by action potentials in efferent motor neurons of the enteric nervous system , or by receptor mediated calcium influx. (wikipedia.org)
  • Additionally increased activities of endogenous regulators of calcineurin like plasma membrane Ca 2+ -ATPase (PMCA) and regulator of calcineurin 1 (RCAN1) also cause neuronal and glial loss and related functional alterations, in neurodegenerative diseases, psychotic disorders, epilepsy, and traumatic brain and spinal cord injuries. (hindawi.com)
  • Inositol 1,4,5-trisphosphate receptors selectively localized to the acrosomes of mammalian sperm. (rupress.org)
  • 2007). «Inositol 1,4,5-trisphosphate receptors are autoantibody target antigens in patients with Sjögren's syndrome and other systemic rheumatic diseases. (wikipedia.org)
  • We produced a plasmid construct expressing the atrial IP3R1 together with green fluorescent protein (GFP), and successfully overexpressed the atrial IP3R1 in the adult atrial cell line HL-1. (biomedcentral.com)
  • Furthermore, double KO mice tended to lose weight rapidly post weaning and typically died 4 weeks after birth. (pancreapedia.org)
  • In this study, we examined tear secretion in mice lacking the inositol 1,4,5-trisphosphate receptor (IP 3 R) types 2 and 3 (Itpr2 -/- ;Itpr3 -/- double-knockout mice). (elsevier.com)
  • Recently, three independent groups in Germany, Japan, and the U.S. provided irrefutable support using PARP-deficient mice for the model shown in Fig. 1 . (diabetesjournals.org)
  • Peptide antibodies colocalized G alpha q/11 and the beta 1 isoform of phospholipase C (PLC beta 1) to the anterior acrosomal region of mouse sperm. (rupress.org)
  • However, in the CA1-CA3 areas of the hippocampus , cerebral cortex , and caudate- putamen , the expression of inositol 1,4,5-trisphosphate receptor mRNA was abruptly decreased at 9 h and almost return to basal level at 24 h after KA injection . (bvsalud.org)
  • In contrast, in polarized cells, this receptor was mostly distributed at the apex of the lateral plasma membrane with the markers of tight junctions, ZO-1 and occludin. (mendeley.com)
  • Addition of calcium to these deprived cells induced the restoration of polarity and the relocalization of the receptor to the plasma membrane. (mendeley.com)
  • 1989 Jan 1;342(6245):87-89. (elsevier.com)
  • Lithium-induced embryonic defects are rescued by supplying an intermediate of the PI cycle, myo -inositol ( Busa & Gimlich 1989 ). (royalsocietypublishing.org)
  • Development of inositol-based antagonists for the D-myo-inositol 1,4,5-trisphosphate receptor. (ox.ac.uk)
  • G q -protein-coupled receptors (G q PCRs) are widely distributed in the CNS and play fundamental roles in a variety of neuronal processes. (jneurosci.org)
  • Chemokines bind to specific G-protein-coupled seven-span transmembrane receptors. (dovepress.com)
  • CXCR4 belongs to the superfamily of the seven transmembrane domain heterotrimeric G protein-coupled receptors and is functionally expressed on the cell surface of various types of cancer cells. (dovepress.com)
  • The inositol 1,4,5-trisphosphate (IP 3 ) receptor (IP 3 R) acts as a Ca 2+ release channel on internal Ca 2+ stores. (sciencemag.org)
  • The inositol 1,4,5 trisphosphate (IP 3 ) receptor (IP 3 R) is a Ca 2+ release channel that responds to the second messenger IP 3 . (elsevier.com)
  • These results indicate that the purified Ins(1,4,5)P 3 binding protein is a physiological receptor responsible for calcium release. (elsevier.com)
  • The authors determined isoflurane-induced cytotoxicity by measuring caspase-3 activity, lactate dehydrogenase release, MTS (3-(4,5-dimethylthiazol-2-yl)-5-(3carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium, inner salt) reduction, and imaging analysis of cell damage markers (annexin V and propidium iodide staining) in different cell types. (asahq.org)
  • These findings suggest that isoflurane activates the ER membrane IP3 receptor, producing excessive calcium release and triggering apoptosis. (asahq.org)
  • Release of calcium from inositol 1,4,5-trisphosphate receptor-regulated stores by HIV-1 Tat regulates TNF-alpha production in human macrophages. (wikipedia.org)
  • Ca 2+ is a key regulator of many cellular functions ( 1 - 3 ), including the release of insulin from pancreatic islet β-cells ( 4 ). (diabetesjournals.org)
  • NO and prostacyclin) and by increasing the production and/or release of different mitogenic stimuli ( e.g. 5-hydroxytryptamine, ET-1, platelet-derived growth factor (PDGF) and vascular endothelial-derived growth factor (VEGF)) and inflammatory mediators ( e.g. interleukin (IL)-6, IL-8 and monocyte chemoattractant factor-1) from SMC, fibroblasts, EC and platelets 13 - 18 . (ersjournals.com)
  • 6 σ1 receptor is one of the subtype belonging to the σ receptors family which was first discovered by Martin in 1976. (rsc.org)
  • We also found that BDNF application rescued the dendritic abnormality of IP 3 R1KO Purkinje cells, and that the increase in BDNF expression in response to activation of AMPA receptor (AMPAR) and metabotropic glutamate receptor (mGluR) was impaired in IP 3 R1KO cerebellar granule cells. (jneurosci.org)
  • FLRFamide and FMRFamide induced small depolarizations (1-2 mV) which triggered a burst of action potentials of about 5 mV which on reaching 4 mV triggered a burst of fast twitch contractions. (lancs.ac.uk)
  • Here we report on serum autoantibodies to ITPR1 (up to 1:15,000) in three patients with (radiculo)polyneuropathy, which in two cases was associated with cancer (ITPR1-expressing adenocarcinoma of the lung, multiple myeloma), suggesting a paraneoplastic aetiology. (biomedcentral.com)
  • The receptor is encoded by 3 distinct genes in mammalian cells (ITPR1, ITPR2, ITPR3) that generate 3 monomeric isoforms (R1, R2, R3 respectively) that share 60-70% sequence homology ( 47 ). (pancreapedia.org)
  • 14,15 The activation of σ1 receptor leads to the transfer of cholesterol, ceramides and essential amino acids that are essential for the growth and proliferation of the neurons, along with an increased gene expression of specific protein and synthesis of various growth factors involved in neuronal outgrowth. (rsc.org)
  • The RF N-terminal sequence appears crucial for receptor activation. (lancs.ac.uk)
  • This implicates a peptide/receptor interaction which activated inositol 1,4,5-trisphosphate (IP3) as a second messenger. (lancs.ac.uk)
  • Ca2+ concentration-dependent interaction of TRPC6 with IP3 receptors or CaM was impaired by introduction in the cells of a peptide corresponding to TRPC6825-875, containing the CIRB site. (physoc.org)
  • Based on the model, we proposed two signal systems in β-cells: one is the CD38-cyclic ADP-ribose (cADPR) signal system for insulin secretion, and the other is the regenerating gene protein (Reg)-Reg receptor system for β-cell regeneration. (diabetesjournals.org)
  • Next, we describe the physiological and pathological roles of the CD38-cyclic ADP-ribose (cADPR) signal system in insulin secretion and the regenerating gene protein (Reg)-Reg receptor system for β-cell regeneration, the elucidations for both of which were developed on the basis of the Okamoto model. (diabetesjournals.org)
  • Binding of an odorant to olfactory receptors triggers cascades of second messenger systems in olfactory receptor neurons (ORNs). (sdbonline.org)
  • Neurons with enhanced IP3 receptor activity, as in certain cases of familial Alzheimer or Huntington disease, may be especially vulnerable to isoflurane cytotoxicity. (asahq.org)
  • [1] These efferent motor neurons of the enteric nervous system are cholinergic and adrenergic neurons. (wikipedia.org)

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