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InosineInosine MonophosphateInosine NucleotidesInosine PranobexInosine TriphosphateHypoxanthinesHypoxanthineAdenosinePurine-Nucleoside PhosphorylaseInosine DiphosphateGuanosineNucleosidesPurine NucleosidesRNA EditingRibonucleosidesPurinesPurine NucleotidesAdenosine A3 Receptor AntagonistsReceptor, Adenosine A3Adenine NucleotidesMycophenolic AcidFormycinsPyrophosphatasesThioinosinePentosyltransferasesAdenineAdenosine Deaminase InhibitorsReceptors, Adenosine A25'-NucleotidaseAdenosine MonophosphateXanthinesXanthineGuanosine MonophosphateTubercidinPhosphoribosyl PyrophosphateNucleoside Transport ProteinsRibosemonophosphatesEquilibrative-Nucleoside Transporter 2Dictionaries, ChemicalAgrochemicalsDictionaries, MedicalDictionaries as TopicBiopharmaceuticsPharmaceutical PreparationsAnticodonInternetDatabases, ProteinUser-Computer InterfaceNucleic Acid ConformationDNASoftwareBase Sequence
Inosine: A purine nucleoside that has hypoxanthine linked by the N9 nitrogen to the C1 carbon of ribose. It is an intermediate in the degradation of purines and purine nucleosides to uric acid and in pathways of purine salvage. It also occurs in the anticodon of certain transfer RNA molecules. (Dorland, 28th ed)Inosine Monophosphate: Inosine 5'-Monophosphate. A purine nucleotide which has hypoxanthine as the base and one phosphate group esterified to the sugar moiety.Inosine NucleotidesInosine Pranobex: An alkylamino-alcohol complex of inosine used in the treatment of a variety of viral infections. Unlike other antiviral agents, it acts by modifying or stimulating cell-mediated immune processes rather than acting on the virus directly.Inosine Triphosphate: Inosine 5'-(tetrahydrogen triphosphate). An inosine nucleotide containing three phosphate groups esterified to the sugar moiety. Synonym: IRPPP.Hypoxanthines: Purine bases related to hypoxanthine, an intermediate product of uric acid synthesis and a breakdown product of adenine catabolism.Hypoxanthine: A purine and a reaction intermediate in the metabolism of adenosine and in the formation of nucleic acids by the salvage pathway.Adenosine: A nucleoside that is composed of ADENINE and D-RIBOSE. Adenosine or adenosine derivatives play many important biological roles in addition to being components of DNA and RNA. Adenosine itself is a neurotransmitter.Purine-Nucleoside Phosphorylase: An enzyme that catalyzes the reaction between a purine nucleoside and orthophosphate to form a free purine plus ribose-5-phosphate. EC 2.4.2.1.Inosine Diphosphate: An inosine nucleotide containing a pyrophosphate group esterified to C5 of the sugar moiety.Guanosine: A purine nucleoside that has guanine linked by its N9 nitrogen to the C1 carbon of ribose. It is a component of ribonucleic acid and its nucleotides play important roles in metabolism. (From Dorland, 28th ed)Nucleosides: Purine or pyrimidine bases attached to a ribose or deoxyribose. (From King & Stansfield, A Dictionary of Genetics, 4th ed)Purine Nucleosides: Purines with a RIBOSE attached that can be phosphorylated to PURINE NUCLEOTIDES.RNA Editing: A process that changes the nucleotide sequence of mRNA from that of the DNA template encoding it. Some major classes of RNA editing are as follows: 1, the conversion of cytosine to uracil in mRNA; 2, the addition of variable number of guanines at pre-determined sites; and 3, the addition and deletion of uracils, templated by guide-RNAs (RNA, GUIDE).Ribonucleosides: Nucleosides in which the purine or pyrimidine base is combined with ribose. (Dorland, 28th ed)Purines: A series of heterocyclic compounds that are variously substituted in nature and are known also as purine bases. They include ADENINE and GUANINE, constituents of nucleic acids, as well as many alkaloids such as CAFFEINE and THEOPHYLLINE. Uric acid is the metabolic end product of purine metabolism.Purine Nucleotides: Purines attached to a RIBOSE and a phosphate that can polymerize to form DNA and RNA.Adenosine A3 Receptor Antagonists: Compounds that selectively bind to and block the activation of ADENOSINE A3 RECEPTORS.Receptor, Adenosine A3: A subtype of ADENOSINE RECEPTOR that is found expressed in a variety of locations including the BRAIN and endocrine tissues. The receptor is generally considered to be coupled to the GI, INHIBITORY G-PROTEIN which causes down regulation of CYCLIC AMP.Adenine NucleotidesMycophenolic Acid: An antibiotic substance derived from Penicillium stoloniferum, and related species. It blocks de novo biosynthesis of purine nucleotides by inhibition of the enzyme inosine monophosphate dehydrogenase. Mycophenolic acid is important because of its selective effects on the immune system. It prevents the proliferation of T-cells, lymphocytes, and the formation of antibodies from B-cells. It also may inhibit recruitment of leukocytes to inflammatory sites. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p1301)Formycins: Pyrazolopyrimidine ribonucleosides isolated from Nocardia interforma. They are antineoplastic antibiotics with cytostatic properties.Pyrophosphatases: A group of enzymes within the class EC 3.6.1.- that catalyze the hydrolysis of diphosphate bonds, chiefly in nucleoside di- and triphosphates. They may liberate either a mono- or diphosphate. EC 3.6.1.-.Thioinosine: Sulfhydryl analog of INOSINE that inhibits nucleoside transport across erythrocyte plasma membranes, and has immunosuppressive properties. It has been used similarly to MERCAPTOPURINE in the treatment of leukemia. (From Martindale, The Extra Pharmacopoeia, 30th ed, p503)Pentosyltransferases: Enzymes of the transferase class that catalyze the transfer of a pentose group from one compound to another.Adenine: A purine base and a fundamental unit of ADENINE NUCLEOTIDES.Adenosine Deaminase Inhibitors: Drugs that inhibit ADENOSINE DEAMINASE activity.Receptors, Adenosine A2: A subclass of ADENOSINE RECEPTORS that are generally considered to be coupled to the GS, STIMULATORY G-PROTEIN which causes up regulation of CYCLIC AMP.5'-Nucleotidase: A glycoprotein enzyme present in various organs and in many cells. The enzyme catalyzes the hydrolysis of a 5'-ribonucleotide to a ribonucleoside and orthophosphate in the presence of water. It is cation-dependent and exists in a membrane-bound and soluble form. EC 3.1.3.5.Adenosine Monophosphate: Adenine nucleotide containing one phosphate group esterified to the sugar moiety in the 2'-, 3'-, or 5'-position.Xanthines: Purine bases found in body tissues and fluids and in some plants.Xanthine: A purine base found in most body tissues and fluids, certain plants, and some urinary calculi. It is an intermediate in the degradation of adenosine monophosphate to uric acid, being formed by oxidation of hypoxanthine. The methylated xanthine compounds caffeine, theobromine, and theophylline and their derivatives are used in medicine for their bronchodilator effects. (Dorland, 28th ed)Guanosine Monophosphate: A guanine nucleotide containing one phosphate group esterified to the sugar moiety and found widely in nature.Tubercidin: An antibiotic purine ribonucleoside that readily substitutes for adenosine in the biological system, but its incorporation into DNA and RNA has an inhibitory effect on the metabolism of these nucleic acids.Phosphoribosyl Pyrophosphate: The key substance in the biosynthesis of histidine, tryptophan, and purine and pyrimidine nucleotides.Nucleoside Transport Proteins: Proteins involved in the transport of NUCLEOSIDES across cellular membranes.Ribosemonophosphates: Ribose substituted in the 1-, 3-, or 5-position by a phosphoric acid moiety.Equilibrative-Nucleoside Transporter 2: A subtype of equilibrative nucleoside transporter proteins that is insensitive to inhibition by 4-nitrobenzylthioinosine.Dictionaries, ChemicalAgrochemicals: Chemicals used in agriculture. These include pesticides, fumigants, fertilizers, plant hormones, steroids, antibiotics, mycotoxins, etc.Dictionaries, MedicalDictionaries as Topic: Lists of words, usually in alphabetical order, giving information about form, pronunciation, etymology, grammar, and meaning.Biopharmaceutics: The study of the physical and chemical properties of a drug and its dosage form as related to the onset, duration, and intensity of its action.Pharmaceutical Preparations: Drugs intended for human or veterinary use, presented in their finished dosage form. Included here are materials used in the preparation and/or formulation of the finished dosage form.Anticodon: The sequential set of three nucleotides in TRANSFER RNA that interacts with its complement in MESSENGER RNA, the CODON, during translation in the ribosome.Internet: A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.Databases, Protein: Databases containing information about PROTEINS such as AMINO ACID SEQUENCE; PROTEIN CONFORMATION; and other properties.User-Computer Interface: The portion of an interactive computer program that issues messages to and receives commands from a user.Nucleic Acid Conformation: The spatial arrangement of the atoms of a nucleic acid or polynucleotide that results in its characteristic 3-dimensional shape.DNA: A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine).Software: Sequential operating programs and data which instruct the functioning of a digital computer.Base Sequence: The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.

Utilization of exogenous purine compounds in Bacillus cereus. Translocation of the ribose moiety of inosine. (1/679)

Intact cells of Bacillus cereus catalyze the breakdown of exogenous AMP to hypoxanthine and ribose 1-phosphate through the successive action of 5'-nucleotidase, adenosine deaminase, and inosine phosphorylase. Inosine hydrolase was not detectable, even in crude extracts. Inosine phosphorylase causes a "translocation" of the ribose moiety (as ribose 1-phosphate) inside the cell, while hypoxanthine remains external. Even though the equilibrium of the phosphorolytic reaction favors nucleoside synthesis, exogenous inosine (as well as adenosine and AMP) is almost quantitatively transformed into external hypoxanthine, since ribose 1-phosphate is readily metabolized inside the cell. Most likely, the translocated ribose 1-phosphate enters the sugar phosphate shunt, via its prior conversion into ribose 5-phosphate, thus supplying the energy required for the subsequent uptake of hypoxanthine in B. cereus.  (+info)

A new synthesis of 5'-deoxy-8,5'-cyclo-adenosine and -inosine: conformationally-fixed purine nucleosides (nucleosides and nucleotides. XVI). (2/679)

A versatile method for the synthesis of 5'-deoxy-8,5'-cycloadenosine, a conformationally-fixed "anti" type of adenosine, was presented. Irradiation of 2', 3'-O-isopropylidene-5'-deoxy-5'-phenylthioadenosine with 60W Hg vapor lamp afforded 2',3'-O-isopropylidene-5'-deoxy-8,5'-cycloadenosine in high yield. The use of other 5'-alkylthio derivatives also gave the cycloadenosine, though the yields were rather poor. Deacetonation of the cyclocompound with 0.1N HCl gave 5'-deoxy-8,5'-cycloadenosine. The cycloinosine derivative was similarly prepared. The nmr, mass and CD spectra of 5'-deoxy-8,5'-cycloadenosine were given and discussed with the previously reported results.  (+info)

Nucleoside-3'-phosphotriesters as key intermediates for the oligoribonucleotide synthesis. III. An improved preparation of nucleoside 3'-phosphotriesters, their 1H NMR characterization and new conditions for removal of 2-cyanoethyl group. (3/679)

An improved procedure for the transformation of 5'-O-monomethoxytrityl-2'-O-acetyl-3'-phosphates of uridine la, inosine ib and 6-N-benzoyladenosine lc into corresponding 3'/2,2,2-trichloroethyl, 2-cyanoethyl/-phosphates iiaic is reported. H NMR characterization of nucleoside 3'-phosphotriesters is presented. New conditions i.e. anhydrous triethylamine-pyridine treatment have been found for the selective removal of 2-cyanoethyl group from nucleoside 3'-phosphotriesters in the presence of neighbouring 2'-O-acetyl one.  (+info)

DNA contacts stimulate catalysis by a poxvirus topoisomerase. (4/679)

Eukaryotic type 1B topoisomerases act by forming covalent enzyme-DNA intermediates that transiently nick DNA and thereby release DNA supercoils. Here we present a study of the topoisomerase encoded by the pathogenic poxvirus molluscum contagiosum. Our studies of DNA sites favored for catalysis reveal a larger recognition site than the 5'-(T/C)CCTT-3' sequence previously identified for poxvirus topoisomerases. Separate assays of initial DNA binding and covalent complex formation revealed that different DNA sequences were important for each reaction step. The location of the protein-DNA contacts was mapped by analyzing mutant sites and inosine-substituted DNAs. Some of the bases flanking the 5'-(T/C)CCTT-3' sequence were selectively important for covalent complex formation but not initial DNA binding. Interactions important for catalysis were probed with 5'-bridging phosphorothiolates at the site of strand cleavage, which permitted covalent complex formation but prevented subsequent religation. Kinetic studies revealed that the flanking sequences that promoted recovery of covalent complexes increased initial cleavage instead of inhibiting resealing of the nicked intermediate. These data 1) indicate that previously unidentified DNA contacts can accelerate a step between initial binding and covalent complex formation and 2) help specify models for conformational changes promoting catalysis.  (+info)

RNA editing of the human serotonin 5-hydroxytryptamine 2C receptor silences constitutive activity. (5/679)

RNA transcripts encoding the serotonin 5-hydroxytryptamine 2C (5-HT2C) receptor (5-HT2CR) undergo adenosine-to-inosine RNA editing events at up to five specific sites. Compared with rat brain, human brain samples expressed higher levels of RNA transcripts encoding the amino acids valine-serine-valine (5-HT2C-VSV) and valine-glycine-valine (5-HT2C-VGV) at positions 156, 158, and 160, respectively. Agonist stimulation of the nonedited human receptor (5-HT2C-INI) and the edited 5-HT2C-VSV and 5-HT2C-VGV receptor variants stably expressed in NIH-3T3 fibroblasts demonstrated that serotonergic agonists were less potent at the edited receptors. Competition binding experiments revealed a guanine nucleotide-sensitive serotonin high affinity state only for the 5-HT2C-INI receptor; the loss of high affinity agonist binding to the edited receptor demonstrates that RNA editing generates unique 5-HT2CRs that couple less efficiently to G proteins. This reduced G protein coupling for the edited isoforms is primarily due to silencing of the constitutive activity of the nonedited 5-HT2CR. The distinctions in agonist potency and constitutive activity suggest that different edited 5-HT2CRs exhibit distinct responses to serotonergic ligands and further imply that RNA editing represents a novel mechanism for controlling physiological signaling at serotonergic synapses.  (+info)

Metabolism and the triggering of germination of Bacillus megaterium. Concentrations of amino acids, organic acids, adenine nucleotides and nicotinamide nucleotides during germination. (6/679)

A considerable amount of evidence suggests that metabolism of germinants or metabolism stimulated by them is involved in triggering bacterial-spore germination. On the assumption that such a metabolic trigger might lead to relatively small biochemical changes in the first few minutes of germination, sensitive analytical techniques were used to detect any changes in spore components during the L-alanine-triggered germination of Bacillus megaterium KM spores. These experiments showed that no changes in spore free amino acids or ATP occurred until 2-3 min after L-alanine addition. Spores contained almost no oxo acids (pyruvate, alpha-oxoglutarate, oxaloacetate), malate or reduced NAD. These compounds were again not detectable until 2-3 min after addition of germinants. It is suggested, therefore, that metabolism associated with these intermediates is not involved in the triggering of germination of this organism.  (+info)

Long RNA hairpins that contain inosine are present in Caenorhabditis elegans poly(A)+ RNA. (7/679)

Adenosine deaminases that act on RNA (ADARs) are RNA-editing enzymes that convert adenosine to inosine within double-stranded RNA. In the 12 years since the discovery of ADARs only a few natural substrates have been identified. These substrates were found by chance, when genomically encoded adenosines were identified as guanosines in cDNAs. To advance our understanding of the biological roles of ADARs, we developed a method for systematically identifying ADAR substrates. In our first application of the method, we identified five additional substrates in Caenorhabditis elegans. Four of those substrates are mRNAs edited in untranslated regions, and one is a noncoding RNA edited throughout its length. The edited regions are predicted to form long hairpin structures, and one of the RNAs encodes POP-1, a protein involved in cell fate decisions.  (+info)

Editing of messenger RNA precursors and of tRNAs by adenosine to inosine conversion. (8/679)

The double-stranded RNA-specific adenosine deaminases ADAR1 and ADAR2 convert adenosine (A) residues to inosine (I) in messenger RNA precursors (pre-mRNA). Their main physiological substrates are pre-mRNAs encoding subunits of ionotropic glutamate receptors or serotonin receptors in the brain. ADAR1 and ADAR2 have similar sequence features, including double-stranded RNA binding domains (dsRBDs) and a deaminase domain. The tRNA-specific adenosine deaminases Tad1p and Tad2p/Tad3p modify A 37 in tRNA-Ala1 of eukaryotes and the first nucleotide of the anticodon (A 34) of several bacterial and eukaryotic tRNAs, respectively. Tad1p is related to ADAR1 and ADAR2 throughout its sequence but lacks dsRBDs. Tad1p could be the ancestor of ADAR1 and ADAR2. The deaminase domains of ADAR1, ADAR2 and Tad1p are very similar and resemble the active site domains of cytosine/cytidine deaminases.  (+info)

The effect of inosine on the inotropic response of the myocardium to isoproterenol and norepinephrine<...The effect of inosine on the inotropic response of the myocardium to isoproterenol and norepinephrine<...
TY - JOUR. T1 - The effect of inosine on the inotropic response of the myocardium to isoproterenol and norepinephrine. AU - Devous, M. D.. AU - Jones, C. E.. PY - 1978/1/1. Y1 - 1978/1/1. UR - http://www.scopus.com/inward/record.url?scp=0018249718&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=0018249718&partnerID=8YFLogxK. M3 - Article. AN - SCOPUS:0018249718. VL - 21. JO - The Physiologist. JF - The Physiologist. SN - 0031-9376. IS - 4. ER - ...
Influence of concomitant infusion of thymidine and inosine on methotrexate activity in normal and P388-bearing miceInfluence of concomitant infusion of thymidine and inosine on methotrexate activity in normal and P388-bearing mice
Combinations of thymidine and inosine (ranging from 0 to 7.5 mg/hr) were co-administered during a 72-hr continuous i.v. infusion of 3 μg/hr methotrexate in normal and P388 solid tumor-bearing DBA/2 mice. Methotrexate alone was lethal to all normal mice. Inosine at 1.0-7.5 mg/hr could reverse toxicity up to 100% while ... read more thymidine at 0.5-7.5 mg/hr was less effective (86% survival). Combinations of the nucleosides averted toxicity more effectively than either compound alone and in a synergistic manner. From P388 tumor-bearing mice 27% survived methotrexate and eventually died of tumor. Co-infusion of thymidine or inosine decreased the percentage of toxic deaths and caused an increase in life span of more than 50% as compared to untreated tumor-bearing mice. However, the diminishing effect on survival with thymidine and inosine doses above 0.5 mg/hr indicated loss of the antitumor effect of methotrexate. This was also observed with combinations of the nucleosides. The influence of ...
The Effect of Methylene Blue and Progesterone Addition to Blood in the Presence of Adenine and Inosine on the Levels of 2,3...The Effect of Methylene Blue and Progesterone Addition to Blood in the Presence of Adenine and Inosine on the Levels of 2,3...
Of the combinations tried, the admixture of methylene blue, progesterone, adenine and inosine maintained 2,3-diphosphoglycerate and adenosine triphosphate at high levels in citrate-phosphate-dextrose blood for a storage period of 6 weeks, about equal to those of the control values on the day of collection. (Author)(*BLOOD
Adenosine-to-inosine RNA editing mediated by ADARs in Esophageal Squamous Cell Carcinoma (Cancer Research, Dec 2013) | Cancer...Adenosine-to-inosine RNA editing mediated by ADARs in Esophageal Squamous Cell Carcinoma (Cancer Research, Dec 2013) | Cancer...
Array ( [0] => 30 [1] => 31 [2] => 32 [3] => 34 [4] => 33 [5] => 49 ) Array ( [1513164984] => Array ( [timeid] => 1513164984 [id] => 14978 [title] => Applications of stimuli-responsive nanoscale drug delivery systems in translational research. (Drug Discov Today, Nov 2017) [time] => 13 December 2017 11:36:24 [postcat] => 30 ) [1511955285] => Array ( [timeid] => 1511955285 [id] => 14880 [title] => CSI Deputy Director, Prof Chng Wee Joo, Appointed Provosts Chair at NUSMed [time] => 29 November 2017 11:34:45 [postcat] => 31 ) [1511286152] => Array ( [timeid] => 1511286152 [id] => 14843 [title] => Triple negative breast cancer in Asia: An insiders view. (Cancer Treat Rev, Nov 2017) [time] => 21 November 2017 17:42:32 [postcat] => 30 ) [1510763331] => Array ( [timeid] => 1510763331 [id] => 14808 [title] => CSI Research Scientist Awarded the ASH Abstract Achievement Award! [time] => 15 November 2017 16:28:51 [postcat] => 31 ) [1510588491] => Array ( [timeid] => 1510588491 [id] => 14803 [title] => ...
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Nucleobase Modifications - Microsynth - DENucleobase Modifications - Microsynth - DE
Historically, the first universal base employed was 2-deoxyInosine (dI). DeoxyInosine is a naturally occurring base that, while not truly universal, is less destabilizing than mismatches involving the four standard bases. Hydrogen bond interactions between dI and dA, dG, dC and dT are weak and unequal, with the result that some base-pairing bias does exist with dI:dC , dI:dA , dI:dG , dI:dT. When present in a DNA template, deoxyInosine preferentially directs incorporation of dC in the growing nascent strand by DNA polymerase.. ...
Inosine CAS 58-63-9 Hypoxanthine ribonucleoside from China manufacturer - MOSINTER GROUP LIMITEDInosine CAS 58-63-9 Hypoxanthine ribonucleoside from China manufacturer - MOSINTER GROUP LIMITED
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Papers - Mangul LabPapers - Mangul Lab
abstract = {Adenosine-to-inosine (A-to-I) RNA editing is a conserved post-transcriptional mechanism mediated by ADAR enzymes that diversifies the transcriptome by altering selected nucleotides in RNA molecules1. Although many editing sites have recently been discovered2,3,4,5,6,7, the extent to which most sites are edited and how the editing is regulated in different biological contexts are not fully understood8,9,10. Here we report dynamic spatiotemporal patterns and new regulators of RNA editing, discovered through an extensive profiling of A-to-I RNA editing in 8,551 human samples (representing 53 body sites from 552 individuals) from the Genotype-Tissue Expression (GTEx) project and in hundreds of other primate and mouse samples. We show that editing levels in non-repetitive coding regions vary more between tissues than editing levels in repetitive regions. Globally, ADAR1 is the primary editor of repetitive sites and ADAR2 is the primary editor of non-repetitive coding sites, whereas the ...
Mechanism of nuclear retention of promiscuously A-to-I edited RNA in h by Zuo Zhang"Mechanism of nuclear retention of promiscuously A-to-I edited RNA in h" by Zuo Zhang
Double-stranded RNA triggers various profound cellular reactions, which depend not only on different intracellular dsRNA locations, but also on the intrinsic structure and length of the duplex. One of the major cellular responses to nuclear dsRNA is the covalent base modification of the target dsRNA by a ubiquitously expressed enzyme, ADAR. ADAR works on dsRNA and alters adenosines to inosines in the RNA duplex. Two types of ADAR editing of dsRNA have been found, selective editing and the promiscuous hyperediting. Hyperedited RNA has been suggested to undergo a novel regulatory pathway. How do cells discriminate between selectively edited mRNAs that encode new protein isoforms, and dsRNA-induced, promiscuously edited RNAs that encode nonfunctional, mutant proteins? We have developed a Xenopus oocyte model system which shows that a variety of hyperedited, inosine-containing RNAs are specifically retained in the nucleus. To uncover the mechanism of inosine-induced retention, HeLa cell nuclear extracts
Crystal Structure of an RNA Quadruplex Containing Inosine Tetrad: Implications for the Roles of NH<sub>2</sub> Group in Purine...Crystal Structure of an RNA Quadruplex Containing Inosine Tetrad: Implications for the Roles of NH<sub>2</sub> Group in Purine...
TY - JOUR. T1 - Crystal Structure of an RNA Quadruplex Containing Inosine Tetrad. T2 - Implications for the Roles of NH2 Group in Purine Tetrads. AU - Pan, Baocheng. AU - Shi, Ke. AU - Sundaralingam, Muttaiya. PY - 2006/10/20. Y1 - 2006/10/20. N2 - Polyinosinic acid has been known to adopt the four-stranded helical structure but its basic unit, inosine tetrad (I tetrad), has not been determined at the atomic level. Here we report the crystal structure of an RNA quadruplex containing an I tetrad at 1.4 Å resolution. The I tetrad has one cyclic hydrogen bond N1...O6 with the bond length of 2.7 Å. A water bridge is observed in the minor groove side of the base tetrad. Even though it is sandwiched by guanine tetrads (G tetrads), the I tetrad is buckled towards the 3′ side of the tetrad plane, which results from the different interaction strength with K ions on two sides of the tetrad plane. Comparison with both G tetrad and adenine tetrad indicates that lack of NH2 in the C2 position makes the I ...
Chemical Database: Inosine 5\-(tetrahydrogen triphosphate), mixt. with adenosine 5\-(trihydrogen diphosphate) sodium salt,...Chemical Database: Inosine 5\'-(tetrahydrogen triphosphate), mixt. with adenosine 5\'-(trihydrogen diphosphate) sodium salt,...
This page contains information on the chemical Inosine 5\-(tetrahydrogen triphosphate), mixt. with adenosine 5\-(trihydrogen diphosphate) sodium salt, inosine and uridine 5\-(tetrahydrogen triphosphate) including: 3 synonyms/identifiers.
GMP Pharmaceutical grade competitive price inosine /58-63-9, View inosine, N&R Product Details from N&R Bio Industries Inc. (Xi...GMP Pharmaceutical grade competitive price inosine /58-63-9, View inosine, N&R Product Details from N&R Bio Industries Inc. (Xi...
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Anabol Naturals Inosine is in its simplest single, free form molecular state and can be readily absorbed by your body. Inosine is a nucleoside, one of the basic compounds comp...
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Plus itPlus it
RNA editing is a regulatory mechanism in which nucleotides are altered posttranscriptionally and most frequently involves conversion of adenosine to inosine, which is recognized as a guanosine during translation. Chen and colleagues performed RNA sequencing analysis to identify molecular changes in hepatocellular carcinoma (HCC) samples that might contribute to disease progression, and they detected elevated adenosine-to-inosine RNA editing of antizyme inhibitor 1 (AZIN1) in HCC samples compared with adjacent normal tissues. The frequency of AZIN1 editing increased during HCC progression and was correlated with liver cirrhosis, tumor recurrence, and poor prognosis, suggesting that this recoding event may promote HCC pathogenesis. AZIN1 RNA modification was mediated by the p110 isoform of adenosine deaminase, RNA-specific (ADAR1), but not by other ADAR family members, and resulted in substitution of glycine for serine at residue 367 in the AZIN1 protein, which was predicted to induce a ...
Plus itPlus it
RNA editing is a regulatory mechanism in which nucleotides are altered posttranscriptionally and most frequently involves conversion of adenosine to inosine, which is recognized as a guanosine during translation. Chen and colleagues performed RNA sequencing analysis to identify molecular changes in hepatocellular carcinoma (HCC) samples that might contribute to disease progression, and they detected elevated adenosine-to-inosine RNA editing of antizyme inhibitor 1 (AZIN1) in HCC samples compared with adjacent normal tissues. The frequency of AZIN1 editing increased during HCC progression and was correlated with liver cirrhosis, tumor recurrence, and poor prognosis, suggesting that this recoding event may promote HCC pathogenesis. AZIN1 RNA modification was mediated by the p110 isoform of adenosine deaminase, RNA-specific (ADAR1), but not by other ADAR family members, and resulted in substitution of glycine for serine at residue 367 in the AZIN1 protein, which was predicted to induce a ...
InosineInosine
The purine ribonucleoside in the nucleotide inosine monophosphate (IMP), from which the purine nucleotides adenosine monophosphate and guanosine monophosphate are derived. Its chemical formula is C10H12N4O5 ...
Inosine 500mg | Source Naturals | Dietary SupplementsInosine 500mg | Source Naturals | Dietary Supplements
Inosine is not an amino acid but is classified as a nucleoside (a building block for DNA and RNA) found in muscle tissue and is one of the basic compounds comprising
Inosine preserves ATP content during ischemia and enhances functional recovery during reperfusion<...Inosine preserves ATP content during ischemia and enhances functional recovery during reperfusion<...
TY - JOUR. T1 - Inosine preserves ATP content during ischemia and enhances functional recovery during reperfusion. AU - Devous, M. D.. AU - Lewandowski, E. D.. PY - 1985. Y1 - 1985. UR - http://www.scopus.com/inward/record.url?scp=0021839650&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=0021839650&partnerID=8YFLogxK. M3 - Article. AN - SCOPUS:0021839650. VL - 44. JO - Federation Proceedings. JF - Federation Proceedings. SN - 0014-9446. IS - 3. ER - ...
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TIGR01698TIGR01698
This clade of purine nucleotide phosphorylases has not been experimentally characterized but is assigned based on strong sequence homology. Closely related clades act on inosine and guanosine (PNPH, TIGR01700), and xanthosine, inosine and guanosine (XAPA, TIGR01699) neither of these will act on adenosine. A more distantly related clade (MTAP, TIGR01694) acts on methylthioadenosine ...
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Friseurscheren Haarschneideschere INOX von Becker Manicure | parfumdreamsFriseurscheren Haarschneideschere INOX von Becker Manicure | parfumdreams
Die Haarschneideschere ist Teil der Serie INOX, die Becker Manicure im Rahmen der Eigenmarke ERBE lanciert. Passend zum Einsatzspektrum von Friseurscheren ist das Modell schmal gearbeitet und läuft sp
CNH Technologies, Inc. | Derivatives of 2 -DeoxyinosineCNH Technologies, Inc. | Derivatives of 2 -Deoxyinosine
You can download our 2017 product catalog in various formats, request to have a hard copy sent to you, or view our products online. ...
RCSB PDB - 1D77: CRYSTAL STRUCTURE OF A B-DNA DODECAMER CONTAINING INOSINE, D(CGCIAATTCGCG), AT 2.4 ANGSTROMS...RCSB PDB - 1D77: CRYSTAL STRUCTURE OF A B-DNA DODECAMER CONTAINING INOSINE, D(CGCIAATTCGCG), AT 2.4 ANGSTROMS...
1D77: Crystal structure of a B-DNA dodecamer containing inosine, d(CGCIAATTCGCG), at 2.4 A resolution and its comparison with other B-DNA dodecamers.
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Sharpening services experience with KorinSharpening services experience with Korin
Based on the advice of the forum, I recently sent two knives out to be professionally sharpened: 240MM Suisin INOX Honyaki wa-gyuto 210MM Masamoto VG (Formerly VG10) Korin in NYC performed the work. The Suisin had been in use in my home kitchen for about 4 months with the OOTB edge. The Masamoto had been in use in my home kitchen for about 3 years, with some touch-up/gentle sharpening of the edge on my waterstones.
Validated Analytical Method Development of Inosine Pranobex in Drug Products by Thin Layer Chromatography :: Science Publishing...Validated Analytical Method Development of Inosine Pranobex in Drug Products by Thin Layer Chromatography :: Science Publishing...
Thin layer chromatography (TLC) with densitometry has been established for the identification and the quantification of inosine pranobex in drug substance and drug products. Inosine pranobex is a combination of inosine, acetamidobenzoic acid, and dimethylaminoisopropanol. UV densitometry was performed in absorbance mode at 260 nm. The separation was carried out on aluminum sheet of silica gel 60 f 254 [chloroform - methanol- - toluene -10% ammonia solution (6:5:1: 0.1% v/v)] as mobile phase. Linearity range was found to be 1-12, 2-12, 2-20 and 2-16 µg/ml for inosine pranobex, inosine, acetamidobenzoic acid, and dimethylaminoisopropanol with the mean percentage recoveries 99.74± 1.73%, 99.88 ± 1.75%, 99.56 ±1.08%, and 99.36 ± 0.71% respectively, (Correlation coefficient r2 = 0.9998 for inosine pranobex, r2 = 0.09999 for inosine, r2 = 0.9998 for acetamidobenzoic acid and r2= 0.9998 for dimethylaminoisopropanol). The detection and quantification limits for inosine pranobex and other components are
Adenosine and inosine exert cytoprotective effects in an in vitro model of liver ischemia-reperfusion injury<...Adenosine and inosine exert cytoprotective effects in an in vitro model of liver ischemia-reperfusion injury<...
TY - JOUR. T1 - Adenosine and inosine exert cytoprotective effects in an in vitro model of liver ischemia-reperfusion injury. AU - Modis, Katalin. AU - Gero, Domokos. AU - Stangl, Rita. AU - Rosero, Olivér. AU - Szijártó, Attila. AU - Lotz, Gábor. AU - Mohácsik, Petra. AU - Szoleczky, Petra. AU - Coletta, Ciro. AU - Szabo, Csaba. PY - 2013/2. Y1 - 2013/2. N2 - Liver ischemia represents a common clinical problem. In the present study, using an in vitro model of hepatic ischemia-reperfusion injury, we evaluated the potential cyto-protective effect of the purine metabolites, such as adenosine and inosine, and studied the mode of their pharmacological actions. The human hepatocellular carcinoma-derived cell line HepG2 was subjected to combined oxygen-glucose deprivation (COGD; 0-14-24 h), followed by re-oxygenation (0-4-24 h). Adenosine or inosine (300-1,000 μM) were applied in pretreatment. Cell viability and cytotoxicity were measured by the 3-(4,5-dimethyl-2-thiazolyl)-2, ...
Adenosine Deaminase | Enzyme | P212121 StoreAdenosine Deaminase | Enzyme | P212121 Store
Adenosine deaminase (ADA) is a purine catabolic enzyme ubiquitous in mammalian tissue which catalyzes deamination of both adenosine and 2-deoxyadenosine to inosine and 2-deoxyinosine respectively. ...
Most recent papers with the keyword Inosine | Read by QxMDMost recent papers with the keyword Inosine | Read by QxMD
The pyrimidine-specific nucleoside hydrolase Yeik (CU-NH) from Escherichia coli cleaves the N-glycosidic bond of uridine and cytidine with a 102~104-fold faster than that of purine nucleoside substrates such as inosine. Such remarkable substrate specificity and the plausible hydrolytic mechanisms of uridine have been explored by using QM/MM and MM MD simulations. The present calculations show that the relatively stronger hydrogen bond interactions between uridine and the active-site residues Gln227 and Tyr231 in CU-NH play an important role in enhancing the substrate binding and thus promoting the N-glycosidic bond cleavage, in comparison with inosine ...
User:Mary Mendoza/Notebook/CHEM 571 Experimental Biological Chemistry I/2012/11/14 - OpenWetWareUser:Mary Mendoza/Notebook/CHEM 571 Experimental Biological Chemistry I/2012/11/14 - OpenWetWare
Running the UV-vis scan for each reagent showed that the increasing trend observed on the ADA kinetic assays was inosine not adenosine. This was verified by recalculating the molar absorptivities. The molar absortivity of inosine at 235 is greater than adenosine. This explains the increase over time since as ADA catalyzes the formation of inosine from adenosine; the catalysis increases the concentration of inosine so as its absorbance ...
Difference between revisions of User:Mary Mendoza/Notebook/CHEM 571 Experimental Biological Chemistry I/2012/11/14 -...Difference between revisions of "User:Mary Mendoza/Notebook/CHEM 571 Experimental Biological Chemistry I/2012/11/14" -...
Running the UV-vis scan for each reagent showed that the increasing trend observed on the ADA kinetic assays was inosine not adenosine. This was verified by recalculating the molar absorptivities. The molar absortivity of inosine at 235 is greater than adenosine. This explains the increase over time since as ADA catalyzes the formation of inosine from adenosine; the catalysis increases the concentration of inosine so as its absorbance ...
The Safety and Effectiveness of Isoprinosine in Patients With Weakened Immune Systems and Lymph Node Disease - Full Text View -...The Safety and Effectiveness of Isoprinosine in Patients With Weakened Immune Systems and Lymph Node Disease - Full Text View -...
The objective of this Phase III, randomized, double-blind, placebo-controlled study in patients with immunologic deficiency is to determine the effect of Isoprinosine in producing an immuno-restorative response within the study observation period (including the 2-month period following cessation of the 28 days of treatment), measured by one or more of the following immunological parameters:. ...
The Safety and Effectiveness of Isoprinosine in Patients With Weakened Immune Systems and Lymph Node Disease - Full Text View -...The Safety and Effectiveness of Isoprinosine in Patients With Weakened Immune Systems and Lymph Node Disease - Full Text View -...
The objective of this Phase III, randomized, double-blind, placebo-controlled study in patients with immunologic deficiency is to determine the effect of Isoprinosine in producing an immuno-restorative response within the study observation period (including the 2-month period following cessation of the 28 days of treatment), measured by one or more of the following immunological parameters:. ...
Glyoxal/borate and RNase T1-based detection of inosine residues in RNAGlyoxal/borate and RNase T1-based detection of inosine residues in RNA
Adenosine-to-inosine (A-to-I) deamination is a functionally important modification of RNA that occurs in many metazoan nuclear transcripts, in several types tRNAs, and in mitochondrial...
RADAR: RNA Editing Database - AboutRADAR: RNA Editing Database - About
RNA editing is the post-transcriptional modification of RNA nucleotides from their genome encoded sequence. The most common type of editing in metazoans is deamination of Adenosine into Inosine catalyzed by the ADAR family of proteins. Subsequently, Inosine is interpreted as Guanosine by the cellular machinery.. The development of high-throughput sequencing technologies has enabled the transcriptome-wide identification of A-to-I editing sites. This database aims to present a comprehensive collection of A-to-I editing sites in human, mouse, and fly transcripts. Useful annotations were incorporated as described in the tutorial.. News:. December 24, 2014: RADAR has been updated to version 2! We have added 8 additional papers to the database. We also removed ~3,000 human genomic SNPs from the database.. October 25, 2013: The RADAR manuscript is now online at Nucleic Acids Research! RADAR: a rigorously annotated database of A-to-I RNA editing. ...
Clinical Trial Considers Inosine Safe and May Lead to Future Treatments to Slow the Progression of PARKINSONS DISEASE -...Clinical Trial Considers Inosine Safe and May Lead to Future Treatments to Slow the Progression of PARKINSON'S DISEASE -...
Clinical Trial Considers Inosine Safe and May Lead to Future Treatments to Slow the Progression of PARKINSONS DISEASE. Michael Schwarzschild, M.D., Ph.D. who is connected to the Harvard School of Public Health and Massachusetts General Hospital has been conducting research with urate levels for many years. In a report issued in May 2012, he stated that they had rather unexpectedly found that people who had higher levels of urate (uric acid) also had a lower than average chance of developing PARKINSONS DISEASE. In that study, they found that urate served as an antioxidant that could protect cells from cell death, however it required the assistance or cooperation of neighboring cells, called astrocytes. Astrocytes are cells that provide both structural and metabolic support to neurons and it is their intervention that determines how the urate is used within the neural cells. The next question was to find out if urate increased artificially would provide the same protection as urate produced ...
Publikationen | Max Planck Institut für medizinische ForschungPublikationen | Max Planck Institut für medizinische Forschung
Melcher, T.; Maas, S.; Higuchi, M.; Keller, W.; Seeburg, P. H.; Major, G.; Larkman, A. U.; Jonas, P.; Sakmann, B.; Jack, J. J. B.: Editing of α-Amino-3-hydroxy-5-methylisoxazole-4-propionic Acid Receptor GluR-B Pre-mRNA in Vitro Reveals Site-selective Adenosine to Inosine Conversion. The Journal of Biological Chemistry 270 (15), S. 8566 - 8570 (1995 ...
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Inosine - DrugBankInosine - DrugBank
A purine nucleoside that has hypoxanthine linked by the N9 nitrogen to the C1 carbon of ribose. It is an intermediate in the degradation of purines and purine nucleosides to uric acid and in pathways of purine salvage. It also occurs in the anticodon of certain transfer RNA molecules. (Dorland, 28th ed)
Stress-Mediated Alterations in Serotonin 2C Receptor Editing and Function - Ronald EmesonStress-Mediated Alterations in Serotonin 2C Receptor Editing and Function - Ronald Emeson
RNA transcripts encoding the 2C-subtype of serotonin receptor (5HT{2C}) can be modified by up to five adenosine-to-inosine (A-to-l) editing events, a process re...
Adjustable thermostat, 0-300°C, 2m capillary, inox sensor : RegulusAdjustable thermostat, 0-300°C, 2m capillary, inox sensor : Regulus
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Geri Halliwell maintains her exercise regime on a daily jog | Daily Mail OnlineGeri Halliwell maintains her exercise regime on a daily jog | Daily Mail Online
She is in a brand new relationship with Red Bull Formula 1 team boss Christian Horner, so it is no wonder Geri Halliwell would want to keep fit and look her best.
Products in Nucleotides, Analogs & Precursors, bioWORLD on Thomas ScientificProducts in Nucleotides, Analogs & Precursors, bioWORLD on Thomas Scientific
* found in: 2-Deoxyuridine, 2-Deoxyguanosine monohydrate, ADP (Adenosine-5-diphosphate), ATP (Adenosine-5-triphosphate), DeoxyUridine, DeoxyInosine,..
FILDENA VS VIAGRA: WHICH IS THE BETTER DRUG?FILDENA VS VIAGRA: WHICH IS THE BETTER DRUG?
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RNA-Tolerant-alignment | DNA Sequencing Software - Sequencher from Gene Codes CorporationRNA-Tolerant-alignment | DNA Sequencing Software - Sequencher from Gene Codes Corporation
GSNAP has been updated and now includes an A-to-G tolerant alignment mode. Use this mode for cases where your mRNA may have been edited by the ADAR gene causing adenosine to be converted to inosine. The I is seen as a G when sequenced.. This version also introduces stranded and non-stranded modes for the new RNA tolerant mode and methylation analysis. Use the non-stranded mode when your laboratory protocol allows 5 to 3 genomic reads and their reverse complements on each strand.. ...
hCNT2 Inhibitor | 534347hCNT2 Inhibitor | 534347
hCNT2 Inhibitor Potently inhibits hCNT2-mediated Na+-dependent inosine uptake (IC₅₀ = 640 nM in COS-7 cells). - Find MSDS or SDS, a COA, data sheets and more information.
Cancer and Careers - Collective Diary - Geri M.Cancer and Careers - Collective Diary - Geri M.
Type and Description of Treatments: 6 rounds of Rituxan and Bendamustine infusion, once every 4 weeks How do you feel today? I have a good amount of energy today, and am feeling both grateful and at peace. Continue Reading ...
Genes, Ecosystems and Risks of Infection - GERI 2015 abstract submission - deadline extended to 15th Dec 2014! | - PALE-Blu...Genes, Ecosystems and Risks of Infection - GERI 2015 abstract submission - deadline extended to 15th Dec 2014! | - PALE-Blu...
To upload data we ask project partners to email the files to us at [email protected] If your dataset is too large for email we can arange for you to upload the files via FTP on request.. For more details click here.... ...
IMP dehydrogenaseIMP dehydrogenase
IMPDH2IMPDH2
Latrodectus mactansLatrodectus mactans
ITPAITPA
IMPDH1IMPDH1
Nucleoside triphosphateNucleoside triphosphate
Multiple sclerosis drug pipelineMultiple sclerosis drug pipeline
BLCAPBLCAP
FLNAFLNA
NucleotideNucleotide
VidarabineVidarabine
Inosinic acidInosinic acid
CBS domainCBS domain
Calcium inosinateCalcium inosinate
Epitranscriptomic sequencingEpitranscriptomic sequencing
Kv1.1Kv1.1
Endonuclease VEndonuclease V
IMPDH/GMPR familyIMPDH/GMPR family
RNARNA
ADARB2ADARB2
AICA ribonucleotideAICA ribonucleotide
NucleosideNucleoside
Nucleic acid metabolismNucleic acid metabolism
Purine nucleoside phosphorylasePurine nucleoside phosphorylase
Subacute sclerosing panencephalitisSubacute sclerosing panencephalitis
GABAA receptorGABAA receptor
Adenosine reuptake inhibitorAdenosine reuptake inhibitor
TAS1R1TAS1R1
Synergistic enhancer (antiretroviral)Synergistic enhancer (antiretroviral)
Taste receptorTaste receptor
Chemicals and DrugsPhenomena and ProcessesDisciplines and OccupationsInformation Science
InosineInosine MonophosphateInosine NucleotidesInosine PranobexInosine TriphosphateHypoxanthinesHypoxanthineAdenosinePurine-Nucleoside PhosphorylaseInosine DiphosphateGuanosineNucleosidesPurine NucleosidesRNA EditingRibonucleosidesPurinesPurine NucleotidesAdenosine A3 Receptor AntagonistsReceptor, Adenosine A3Adenine NucleotidesMycophenolic AcidFormycinsPyrophosphatasesThioinosinePentosyltransferasesAdenineAdenosine Deaminase InhibitorsReceptors, Adenosine A25'-NucleotidaseAdenosine MonophosphateXanthinesXanthineGuanosine MonophosphateTubercidinPhosphoribosyl PyrophosphateNucleoside Transport ProteinsRibosemonophosphatesEquilibrative-Nucleoside Transporter 2Dictionaries, ChemicalAgrochemicalsDictionaries, MedicalDictionaries as TopicBiopharmaceuticsPharmaceutical PreparationsAnticodonInternetDatabases, ProteinUser-Computer InterfaceNucleic Acid ConformationDNASoftwareBase Sequence
Inosine - Drugs.comInosine - Drugs.com
Buy Source Naturals Inosine - 120 Tablet - eVitamins AustraliaBuy Source Naturals Inosine - 120 Tablet - eVitamins Australia
InosineInosine
Anabol Naturals Inosine 500 mg 240 Caps - Swanson®Anabol Naturals Inosine 500 mg 240 Caps - Swanson®
Chemical Database: Inosine 5\-(tetrahydrogen triphosphate), mixt. with adenosine 5\-(trihydrogen diphosphate) sodium salt,...Chemical Database: Inosine 5\'-(tetrahydrogen triphosphate), mixt. with adenosine 5\'-(trihydrogen diphosphate) sodium salt,...
Mega-Pro Inosine - Compare Prices & Save at PricePlowMega-Pro Inosine - Compare Prices & Save at PricePlow
The Effect of Methylene Blue and Progesterone Addition to Blood in the Presence of Adenine and Inosine on the Levels of 2,3...The Effect of Methylene Blue and Progesterone Addition to Blood in the Presence of Adenine and Inosine on the Levels of 2,3...
INOSINE (15N4, 95%+) - Creative ProteomicsINOSINE (15N4, 95%+) - Creative Proteomics
Inosine 500mg | Source Naturals | Dietary SupplementsInosine 500mg | Source Naturals | Dietary Supplements
Inosine 5-triphosphate,periodate oxidized sodium salt - Alfa ChemistryInosine 5'-triphosphate,periodate oxidized sodium salt - Alfa Chemistry
Inosine CAS 58-63-9 Hypoxanthine ribonucleoside from China manufacturer - MOSINTER GROUP LIMITEDInosine CAS 58-63-9 Hypoxanthine ribonucleoside from China manufacturer - MOSINTER GROUP LIMITED
Influence of concomitant infusion of thymidine and inosine on methotrexate activity in normal and P388-bearing miceInfluence of concomitant infusion of thymidine and inosine on methotrexate activity in normal and P388-bearing mice
Inosine preserves ATP content during ischemia and enhances functional recovery during reperfusion<...Inosine preserves ATP content during ischemia and enhances functional recovery during reperfusion<...
Adenosine-to-inosine RNA editing mediated by ADARs in Esophageal Squamous Cell Carcinoma (Cancer Research, Dec 2013) | Cancer...Adenosine-to-inosine RNA editing mediated by ADARs in Esophageal Squamous Cell Carcinoma (Cancer Research, Dec 2013) | Cancer...
Crystal Structure of an RNA Quadruplex Containing Inosine Tetrad: Implications for the Roles of NH<sub>2</sub> Group in Purine...Crystal Structure of an RNA Quadruplex Containing Inosine Tetrad: Implications for the Roles of NH<sub>2</sub> Group in Purine...
GMP Pharmaceutical grade competitive price inosine /58-63-9, View inosine, N&R Product Details from N&R Bio Industries Inc. (Xi...GMP Pharmaceutical grade competitive price inosine /58-63-9, View inosine, N&R Product Details from N&R Bio Industries Inc. (Xi...
TIGR01698TIGR01698
Plus itPlus it
Nucleobase Modifications - Microsynth - DENucleobase Modifications - Microsynth - DE
inosine (CHEBI:17596)inosine (CHEBI:17596)
Inosine Pranobex - Drugs.comInosine Pranobex - Drugs.com
Inosine - WikipediaInosine - Wikipedia
Inosine pranobex - WikipediaInosine pranobex - Wikipedia
Inosine: Uses, Side Effects, Interactions, Dosage, and WarningInosine: Uses, Side Effects, Interactions, Dosage, and Warning
inosine-5-monophosphate dehydrogenase [Psychromonas ingrahamii 37] - Protein - NCBIinosine-5'-monophosphate dehydrogenase [Psychromonas ingrahamii 37] - Protein - NCBI
Adding Inosine at level 3 ? | Eterna ForumAdding Inosine at level 3 ? | Eterna Forum
Inosine dictionary definition | inosine definedInosine dictionary definition | inosine defined
Inosine - DrugBankInosine - DrugBank
2B1I: Crystal Structures Of Transition State Analogue Inhibitors Of Inosine Monophosphate Cyclohydrolase2B1I: Crystal Structures Of Transition State Analogue Inhibitors Of Inosine Monophosphate Cyclohydrolase
Variants of the inosine t… - University of Gothenburg, Sweden Variants of the inosine t… - University of Gothenburg, Sweden
Inosine | definition of inosine by Medical dictionaryInosine | definition of inosine by Medical dictionary
RCSB PDB - 114D: INOSINE-ADENINE BASE PAIRS IN A B-DNA DUPLEXRCSB PDB - 114D: INOSINE-ADENINE BASE PAIRS IN A B-DNA DUPLEX
RCSB PDB - 3KHJ: C. parvum inosine monophosphate dehydrogenase bound by inhibitor C64RCSB PDB - 3KHJ: C. parvum inosine monophosphate dehydrogenase bound by inhibitor C64
guaB - Inosine-5-monophosphate dehydrogenase - Yersinia pestis - guaB gene & proteinguaB - Inosine-5'-monophosphate dehydrogenase - Yersinia pestis - guaB gene & protein
yjjX - Inosine/xanthosine triphosphatase - Escherichia coli (strain K12) - yjjX gene & proteinyjjX - Inosine/xanthosine triphosphatase - Escherichia coli (strain K12) - yjjX gene & protein
Impdh2 MGI Mouse Gene Detail - MGI:109367 - inosine monophosphate dehydrogenase 2Impdh2 MGI Mouse Gene Detail - MGI:109367 - inosine monophosphate dehydrogenase 2
Treatment of Multiple Sclerosis Using Over the Counter Inosine - Full Text View - ClinicalTrials.govTreatment of Multiple Sclerosis Using Over the Counter Inosine - Full Text View - ClinicalTrials.gov
Source Naturals Inosine - 60 Tablet - eVitamins.comSource Naturals Inosine - 60 Tablet - eVitamins.com
Inosine 5-monophosphate | definition of inosine 5-monophosphate by Medical dictionaryInosine 5-monophosphate | definition of inosine 5-monophosphate by Medical dictionary
Inosine-5-monophosphate dehydrogenase (Bacillus anthracis) | Protein Target - PubChemInosine-5'-monophosphate dehydrogenase (Bacillus anthracis) | Protein Target - PubChem
Glutamate receptor RNA editing in vitro by enzymatic conversion of adenosine to inosine | ScienceGlutamate receptor RNA editing in vitro by enzymatic conversion of adenosine to inosine | Science
Anti-inosine 5-phosphate dehydrogenase 2 Antibody Products from Novus Biologicals | BiocompareAnti-inosine 5'-phosphate dehydrogenase 2 Antibody Products from Novus Biologicals | Biocompare
Differential Sensitivities of Fast- and Slow-Cycling Cancer Cells to Inosine Monophosphate Dehydrogenase 2 Inhibition by...Differential Sensitivities of Fast- and Slow-Cycling Cancer Cells to Inosine Monophosphate Dehydrogenase 2 Inhibition by...
Inosine-5-Triphosphate | TriLink BioTechnologiesInosine-5'-Triphosphate | TriLink BioTechnologies
Type I Inosine Monophosphate Dehydrogenase: Evidence for a Single Functional Gene in Mammalian SpeciesType I Inosine Monophosphate Dehydrogenase: Evidence for a Single Functional Gene in Mammalian Species
Chemicals and DrugsPhenomena and ProcessesDisciplines and OccupationsInformation Science
InosineInosine MonophosphateInosine NucleotidesInosine PranobexInosine TriphosphateHypoxanthinesHypoxanthineAdenosinePurine-Nucleoside PhosphorylaseInosine DiphosphateGuanosineNucleosidesPurine NucleosidesRNA EditingRibonucleosidesPurinesPurine NucleotidesAdenosine A3 Receptor AntagonistsReceptor, Adenosine A3Adenine NucleotidesMycophenolic AcidFormycinsPyrophosphatasesThioinosinePentosyltransferasesAdenineAdenosine Deaminase InhibitorsReceptors, Adenosine A25'-NucleotidaseAdenosine MonophosphateXanthinesXanthineGuanosine MonophosphateTubercidinPhosphoribosyl PyrophosphateNucleoside Transport ProteinsRibosemonophosphatesEquilibrative-Nucleoside Transporter 2Dictionaries, ChemicalAgrochemicalsDictionaries, MedicalDictionaries as TopicBiopharmaceuticsPharmaceutical PreparationsAnticodonInternetDatabases, ProteinUser-Computer InterfaceNucleic Acid ConformationDNASoftwareBase Sequence
Adenosine triphosphateGuanosineNaturalsInhibitorPlays many supportive rolesRiboseNucleotideRolesAmino acidChemicalWorkBloodContentBodyBasicNormalEffectMonophosphate dehydrogenaseNucleosidePranobexMetabolismIMPDHTreatment with inosineAdministration of inosineSource NaturalsMetabolite inosineTriphosphate pyrophosphatasePrecursorMoleculeSupplementationLevels of uric acidPlacebo or inosineEffects of AdenosineTolerability of inosineUridineGeneUricPremium InosineNaturals InosineTriphosphatase deficiencyDeamination of adenosineNeuroprotectiveParkinson'sClinicalMultiple sclerosisUrate levelsRibonucleosideAbstractITPaseOrallyAntiviralEnzymeNucleosidesSerumExogenousSodium pyruvateAdenosine monophosphateXanthineAnti-inflammatoryCatabolism
Adenosine triphosphate1
Guanosine1
  • RNA editing is a regulatory mechanism in which nucleotides are altered posttranscriptionally and most frequently involves conversion of adenosine to inosine, which is recognized as a guanosine during translation. (aacrjournals.org)
Naturals1
Inhibitor1
  • Chen and colleagues performed RNA sequencing analysis to identify molecular changes in hepatocellular carcinoma (HCC) samples that might contribute to disease progression, and they detected elevated adenosine-to-inosine RNA editing of antizyme inhibitor 1 ( AZIN1 ) in HCC samples compared with adjacent normal tissues. (aacrjournals.org)
Plays many supportive roles1
Ribose1
Nucleotide1
  • Metabolically, Inosine is an intermediate in a number of purine nucleotide pathways that affect the ability of the muscle to work efficiently. (biovea.com)
Roles1
  • Pan, B , Shi, K & Sundaralingam, M 2006, ' Crystal Structure of an RNA Quadruplex Containing Inosine Tetrad: Implications for the Roles of NH 2 Group in Purine Tetrads ', Journal of Molecular Biology , vol. 363, no. 2, pp. 451-459. (umn.edu)
Amino acid1
  • Inosine is not an amino acid but is classified as a nucleoside (a building block for DNA and RNA) found in muscle tissue and is one of the basic compounds comprising cells. (biovea.com)
Chemical1
Work1
Blood1
  • Inosine is a naturally occurring compound in the body that supports normal cardiovascular function and blood flow. (priceplow.com)
Content1
  • Devous, MD & Lewandowski, ED 1985, ' Inosine preserves ATP content during ischemia and enhances functional recovery during reperfusion ', Federation Proceedings , vol. 44, no. 3. (elsevier.com)
Body2
  • Inosine provides a safe and effective way to enable the body to utilize oxygen more efficiently. (priceplow.com)
  • When maximum stimulation is reached Inosine is converted into nutrients used by the body. (biovea.com)
Basic2
  • Inosine is a nucleoside, one of the basic compounds comprising cells. (swansonvitamins.com)
  • Polyinosinic acid has been known to adopt the four-stranded helical structure but its basic unit, inosine tetrad (I tetrad), has not been determined at the atomic level. (umn.edu)
Normal1
  • Combinations of thymidine and inosine (ranging from 0 to 7.5 mg/hr) were co-administered during a 72-hr continuous i.v. infusion of 3 μg/hr methotrexate in normal and P388 solid tumor-bearing DBA/2 mice. (uu.nl)
Effect2
  • However, the diminishing effect on survival with thymidine and inosine doses above 0.5 mg/hr indicated loss of the antitumor effect of methotrexate. (uu.nl)
  • It is concluded that co-administration of inosine and/or thymidine allows the use of methotrexate doses otherwise not tolerated, though with loss of anti-tumor effect. (uu.nl)
Monophosphate dehydrogenase20
Nucleoside6
  • Inosine is a nucleoside that is formed when hypoxanthine is attached to a ribose ring (also known as a ribofuranose) via a β-N9-glycosidic bond. (wikipedia.org)
  • Inosine is a nucleoside, one of the basic compounds comprising cells. (swansonvitamins.com)
  • Inosine 5'-triphosphate (ITP) also functions as an alternative substrate for ATPases and GTPases and has been used to study activation and binding kinetics of nucleoside interaction with various ATPases and GTPases. (trilinkbiotech.com)
  • Inosine is not an amino acid but is classified as a nucleoside (a building block for DNA and RNA) found in muscle tissue and is one of the basic compounds comprising cells. (biovea.com)
  • cp wz table border top 1px solid ccc border left 1px solid ccc cp wz table td border right 1px solid ccc border bottom 1px solid ccc padding 5px 0px 0px 5px cp wz table th border right 1px solid ccc border bottom 1px solid ccc padding 5px 0px 0px 5px Molecular Weight 268 23 Inosine is a nucleoside. (pharmachemm.com)
  • New from Swanson Premium, Inosine is a fundamental nucleoside with a broad range of functions. (swansonaustralia.com)
Pranobex12
Metabolism10
IMPDH2
Treatment with inosine4
  • As the usage of inosine for avoidance of reperfusion damage in the framework of cardiopulmonary bypass hasn't yet been looked into, the purpose of the present research was to check the hypothesis that treatment with inosine during reperfusion increases myocardial, and endothelial function within a medically relevant canine style of extracorporal flow. (acmbcb.org)
  • Having established these positive results, researchers have now begun a multicenter Phase 2 trial ( NCT03168711 ), called SURE-ALS2, to further evaluate treatment with inosine over a 20-week period. (alsnewstoday.com)
  • As shown in Table 1, the treatment with inosine induced an increase in the amount of mitochondrial protein and the mitochondrial genome copy number, which are biochemical markers of mitochondrial content, and therefore, reflect an increased number of mitochondria in the more differentiated intestinal cells (Djouadi et al. (raypeatforum.com)
  • We observed a 40% decrease in lactate dehydrogenase activity in intestinal cells following treatment with inosine (Table 1). (raypeatforum.com)
Administration of inosine3
Source Naturals1
Metabolite inosine2
Triphosphate pyrophosphatase2
  • Variants of the inosine triphosphate pyrophosphatase gene are associated with reduced relapse risk following treatment for HCV genotype 2/3. (gu.se)
  • The present study evaluated the impact of variations in the inosine triphosphate pyrophosphatase (ITPase) gene (ITPA) on treatment outcome in patients with hepatitis C virus (HCV) genotype 2/3 infection receiving peginterferon-α2a and lower, conventional 800 mg daily dose of ribavirin. (gu.se)
Precursor5
  • The purpose of this study is to determine whether raising low levels of the natural antioxidant uric acid by the administration of a precursor, inosine, has any therapeutic effect on the progression of Relapsing Remitting Multiple Sclerosis (RRMS) and secondary progressive Multiple Sclerosis (MS). (clinicaltrials.gov)
  • The primary purpose of this study to determine whether raising low serum uric acid levels by daily oral administration of its precursor inosine has an effect on the cumulative number of newly active lesions on magnetic resonance imaging (MRI) and to evaluate the safety and tolerability of inosine in patients diagnosed with relapsing remitting and secondary progressive MS. (clinicaltrials.gov)
  • We aimed to investigate the UA elevating capability, safety, and tolerability of inosine 5'-monophosphate, a precursor of uric acid, in MSA patients with randomized, placebo controlled, and parallel assigned design. (clinicaltrials.gov)
  • These findings warrant clinical trials testing urate, according to the authors, which can be conducted through the administration of urate's precursor compound, inosine. (alsnewstoday.com)
  • Inosine, an orally bioavailable precursor of urate, was investigated in a phase 2 study, the Safety of Urate Elevation in Parkinson's Disease (SURE-PD) trial. (grantome.com)
Molecule2
Supplementation4
Levels of uric acid1
  • Multiple sclerosis (MS). Some research shows that having low uric acid levels increases the risk of developing MS. Research in adults with MS shows that taking inosine increases the levels of uric acid in the blood . (webmd.com)
Placebo or inosine2
  • All participants are randomized to study drugs, either tablet of placebo or inosine 5'-monophosphate, in 1 to 1 ratio and then undergo scheduled titration. (clinicaltrials.gov)
  • Methods: A placebo-controlled, double-blind randomized trial of inosine will enroll 270 subjects with early PD, lower serum urate and DAT deficiency by neuroimaging and will randomize them 1:1 to treatment with placebo or inosine dosed to elevate urate for 2 years with a 3-month wash-out. (grantome.com)
Effects of Adenosine2
Tolerability of inosine1
  • A purpose of the present study is to investigate the capability of serum uric acid elevation, safety, and tolerability of inosine 5'-monophosphate in patients with multiple system atrophy with multicenter, randomized, placebo controlled, parallel assigned design. (clinicaltrials.gov)
Uridine5
  • Yamamoto T, Moriwaki Y, Cheng J, Takahashi S, Tsutsumi Z, Ka T, Hada T. Effect of inosine on the plasma concentration of uridine and purine bases. (webmd.com)
  • In a second series of experiments, uridine (10(-4)-10(-5) M) and inosine (10(-4)-10(-7) M) inhibited the relase of glycerol from isolated rat epididymal adipose tissue in Krebs-bicarbonate buffer. (aspetjournals.org)
  • Uridine and inosine in concentrations of 10(-4) M inhibited the epinephrine (10(-5) M)-, the norepinephrine (10(-5) M)- and the theophylline (10(-3) M)-stimulated lipolysis. (aspetjournals.org)
  • Dibutyryl 3',5'-adenosine monophosphate-stimulated lipolysis was further activated in the presence of 10(-4) M uridine or inosine. (aspetjournals.org)
  • Dose-response curves studies suggested that inosine, but not uridine, has a common receptor site with epinephrine in adipose tissue. (aspetjournals.org)
Gene1
  • 1994). In accordance to this, inosine-treatment induced gene expression of TFAM, which is a key activator of mitochondrial transcription as well as a participant in mitochondrial genome replication. (raypeatforum.com)
Uric5
Premium Inosine2
  • Premium Inosine can help increase the body's ability to carry oxygen without affecting uptake in the lungs, therefore you can work harder and stronger. (ultimatenutrition.com)
  • Our Premium Inosine capsules guarantee the highest potency and are of the highest quality. (ultimatenutrition.com)
Naturals Inosine1
Triphosphatase deficiency1
Deamination of adenosine1
Neuroprotective4
  • It has been shown that inosine has neuroprotective properties. (wikipedia.org)
  • Inosine may have neuroprotective, cardioprotective, anti-inflammatory and immunomodulatory activities. (drugbank.ca)
  • Treatment with a compound called inosine over 12 weeks increased the levels of the antioxidant urate, a neuroprotective agent, in patients with amyotrophic lateral sclerosis (ALS), according to a pilot trial. (alsnewstoday.com)
  • These findings, together with epidemiological observations and preclinical data supporting a neuroprotective role of urate in ALS models, provide the rationale for larger clinical trials testing inosine as a potential disease‐modifying therapy for ALS. (alsnewstoday.com)
Parkinson's2
  • This has already been done in Parkinson's disease patients, with a Phase 2 trial ( NCT00833690 ) showing that inosine raised urate levels in the serum and the cerebrospinal fluid (the liquid surrounding the brain and spinal cord) with a good safety profile. (alsnewstoday.com)
  • Inosine has been used in clinical trials for multiple sclerosis and Parkinson's disease, and has been shown to help regenerate nerve fibers in previous research. (bobbyschindler.com)
Clinical5
  • Despite lack of clinical evidence that it improves muscle development, inosine remains an ingredient in some fitness supplements. (wikipedia.org)
  • Associated inosine to interferon: results of a clinical trial in multiple sclerosis. (webmd.com)
  • Inosine to increase serum and cerebrospinal fluid urate in Parkinson disease: a randomized clinical trial. (webmd.com)
  • In terms of clinical implications, Inosine, which appears to have no apparent side effects in animals thus far, has potential as a novel nerve regeneration approach to treatment of stroke and other types of brain injuries. (rutgers.edu)
  • The Phase 2 SURE-ALS2 trial, now ongoing, "will serve as a helpful stepping stone in preparation for a future multicenter pivotal trial testing the effects of inosine on clinical outcomes," the investigators said. (alsnewstoday.com)
Multiple sclerosis2
Urate levels3
  • The trial uses inosine to raise urate levels in those with levels lower than the population mean (6 mg/dL). (wikipedia.org)
  • Aimed at studying the ability of inosine to elevate urate levels in ALS patients, the open-label, 12-week pilot study ( NCT02288091 ) enrolled 25 ALS patients at Massachusetts General Hospital . (alsnewstoday.com)
  • Inosine appeared safe, well tolerated, and effective in raising serum urate levels in people with ALS," the scientists wrote. (alsnewstoday.com)
Ribonucleoside1
Abstract2
  • Graphical abstract The relative stability of intramolecular quadruplexes containing inosine substitutions is different in sodium and potassium. (soton.ac.uk)
  • abstract = "The effects of the complexes of inosine (Ino) analogues of isoprinosine on the immune response to sheep red blood cells (SRBC), in plaque-forming cells assay (PFC), in mice spleen, and on the Fc-dependent SRBC phagocytosis in mice peritoneal macrophages were investigated. (elsevier.com)
ITPase1
  • The purine analogues tenofovir and abacavir are precursors of potential substrates for the enzyme Inosine 5'-triphosphate pyrophosphohydrolase (ITPase). (readbyqxmd.com)
Orally1
  • For the first two weeks, patients took two daily 500 mg capsules of inosine - orally or through a feeding tube. (alsnewstoday.com)
Antiviral1
  • also known as inosine acedoben dimepranol (INN) or methisoprinol) an antiviral drug that is a combination of inosine and dimepranol acedoben (a salt of acetamidobenzoic acid and dimethylaminoisopropanol) in a ratio of 1 to 3. (wikipedia.org)
Enzyme2
Nucleosides1
  • The mechanism of antilipolytic action of these nucleosides is unknown, but one of the receptor sites for inosine might be adenylate cyclase. (aspetjournals.org)
Serum1
  • It demonstrated that inosine can safely produce well-tolerated elevations of serum and CSF urate for months or years in early PD. (grantome.com)
Exogenous2
  • Exogenous inosine may contribute to the high-energy phosphate pool of cardiac muscle cells and favorably affect bioenergetics generally. (drugbank.ca)
  • Although inosine has been used clinically to support the myocardium, no data are available on the fate of exogenous inosine in the human heart. (eur.nl)
Sodium pyruvate1
Adenosine monophosphate1
Xanthine1
Anti-inflammatory5
Catabolism1
Anabol Naturals Inosine 500 mg 240 Caps - Swanson®
Anabol Naturals Inosine 500 mg 240 Caps - Swanson® (swansonvitamins.com)
Buy Source Naturals Inosine - 120 Tablet - eVitamins Australia
Buy Source Naturals Inosine - 120 Tablet - eVitamins Australia (evitamins.com)
Mega-Pro Inosine - Compare Prices & Save at PricePlow
Mega-Pro Inosine - Compare Prices & Save at PricePlow (priceplow.com)
Nucleobase Modifications - Microsynth - DE
Nucleobase Modifications - Microsynth - DE (microsynth.seqlab.de)
GMP Pharmaceutical grade competitive price inosine /58-63-9, View inosine, N&R Product Details from N&R Bio Industries Inc. (Xi...
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Inosine preserves ATP content during ischemia and enhances functional recovery during reperfusion<...
Inosine preserves ATP content during ischemia and enhances functional recovery during reperfusion<... (utsouthwestern.pure.elsevier.com)
Inosine CAS 58-63-9 Hypoxanthine ribonucleoside from China manufacturer - MOSINTER GROUP LIMITED
Inosine CAS 58-63-9 Hypoxanthine ribonucleoside from China manufacturer - MOSINTER GROUP LIMITED (mosinter.en.hisupplier.com)
PlanHab Study: Consequences of combined normobaric hypoxia and bed rest on adenosine kinetics | Scientific Reports
PlanHab Study: Consequences of combined normobaric hypoxia and bed rest on adenosine kinetics | Scientific Reports (nature.com)
Marine Drugs | Free Full-Text | Marine-Derived Natural Compounds for the Treatment of Parkinson's Disease | HTML
Marine Drugs | Free Full-Text | Marine-Derived Natural Compounds for the Treatment of Parkinson's Disease | HTML (mdpi.com)
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PDB 2car structure summary ‹ Protein Data Bank in Europe (PDBe) ‹ EMBL-EBI (ebi.ac.uk)
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Adding Inosine at level 3 ? | Eterna Forum (getsatisfaction.com)
Frontiers | Sequence Determinants for Nuclear Retention and Cytoplasmic Export of mRNAs and lncRNAs | Genetics
Frontiers | Sequence Determinants for Nuclear Retention and Cytoplasmic Export of mRNAs and lncRNAs | Genetics (frontiersin.org)
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What We Fund: $6 Million in New Grants for Parkinson s Research | Parkinson's Disease (michaeljfox.org)
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Uncovering the Promise of c-Abl as a Therapeutic Target: Testing Available Treatments and Supporting New Therapies | Parkinson... (michaeljfox.org)
IUCr) Acta Crystallographica Section B Volume 26, Part 8, August 1970
IUCr) Acta Crystallographica Section B Volume 26, Part 8, August 1970 (journals.iucr.org)
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RCSB PDB - 114D: INOSINE-ADENINE BASE PAIRS IN A B-DNA DUPLEX (rcsb.org)
Treatment of Multiple Sclerosis Using Over the Counter Inosine - Full Text View - ClinicalTrials.gov
Treatment of Multiple Sclerosis Using Over the Counter Inosine - Full Text View - ClinicalTrials.gov (clinicaltrials.gov)
Can We Cure NO/ONOO (Feb/March 2010) Townsend Letter for Doctors & Patients
Can We Cure NO/ONOO (Feb/March 2010) Townsend Letter for Doctors & Patients (townsendletter.com)
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Course Content - #98771: Parkinson Disease - NetCE
Course Content - #98771: Parkinson Disease - NetCE (netce.com)
PLOS Neglected Tropical Diseases: Publishing science, accelerating research
PLOS Neglected Tropical Diseases: Publishing science, accelerating research (journals.plos.org)
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SWISS-MODEL Template Library | 4q32.1 (swissmodel.expasy.org)
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This Is MS Multiple Sclerosis Knowledge & Support Community - Search (thisisms.com)
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021:2015: ??? 33600000-6 ???????????????? ?????????? (???????????????? ?????? ) 33600000-6 - ???????????????? ??? : ????????... (tendergid.ua)
MELTING, a flexible platform to predict the melting temperatures of nucleic acids | BMC Bioinformatics | Full Text
MELTING, a flexible platform to predict the melting temperatures of nucleic acids | BMC Bioinformatics | Full Text (bmcbioinformatics.biomedcentral.com)
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PNP gene: MedlinePlus Genetics (medlineplus.gov)
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Performance & Enhancement Aids in Family Planning at SHOP.COM Health & Nutrition (shop.com)
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June 1997 - Volume 19 - Issue 3 : Therapeutic Drug Monitoring (journals.lww.com)
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Activation of anti-hepatitis C virus responses via Toll-like receptor 7 | PNAS (pnas.org)
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ITP(4-) (CHEBI:61402) (ebi.ac.uk)
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IDP(3-) (CHEBI:58280) (ebi.ac.uk)
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Multiplex Genotyping of Allelic Variants of Genes Involved in Metabolizing Antileukemic Drugs | SpringerLink (link.springer.com)
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Neurosciences | IOS Press - Part 5 (iospress.nl)