A partial or complete return to the normal or proper physiologic activity of an organ or part following disease or trauma.
A short-acting opioid anesthetic and analgesic derivative of FENTANYL. It produces an early peak analgesic effect and fast recovery of consciousness. Alfentanil is effective as an anesthetic during surgery, for supplementation of analgesia during surgical procedures, and as an analgesic for critically ill patients.
The period of emergence from general anesthesia, where different elements of consciousness return at different rates.
Elements of limited time intervals, contributing to particular results or situations.
Damage inflicted on the body as the direct or indirect result of an external force, with or without disruption of structural continuity.
An intravenous anesthetic agent which has the advantage of a very rapid onset after infusion or bolus injection plus a very short recovery period of a couple of minutes. (From Smith and Reynard, Textbook of Pharmacology, 1992, 1st ed, p206). Propofol has been used as ANTICONVULSANTS and ANTIEMETICS.
Drugs used to induce drowsiness or sleep or to reduce psychological excitement or anxiety.
Acute and chronic (see also BRAIN INJURIES, CHRONIC) injuries to the brain, including the cerebral hemispheres, CEREBELLUM, and BRAIN STEM. Clinical manifestations depend on the nature of injury. Diffuse trauma to the brain is frequently associated with DIFFUSE AXONAL INJURY or COMA, POST-TRAUMATIC. Localized injuries may be associated with NEUROBEHAVIORAL MANIFESTATIONS; HEMIPARESIS, or other focal neurologic deficits.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
The rate dynamics in chemical or physical systems.
A procedure in which a laparoscope (LAPAROSCOPES) is inserted through a small incision near the navel to examine the abdominal and pelvic organs in the PERITONEAL CAVITY. If appropriate, biopsy or surgery can be performed during laparoscopy.
Penetrating and non-penetrating injuries to the spinal cord resulting from traumatic external forces (e.g., WOUNDS, GUNSHOT; WHIPLASH INJURIES; etc.).
Injuries incurred during participation in competitive or non-competitive sports.
The period of confinement of a patient to a hospital or other health facility.
Adverse functional, metabolic, or structural changes in ischemic tissues resulting from the restoration of blood flow to the tissue (REPERFUSION), including swelling; HEMORRHAGE; NECROSIS; and damage from FREE RADICALS. The most common instance is MYOCARDIAL REPERFUSION INJURY.
The relationship between the dose of an administered drug and the response of the organism to the drug.
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
The normality of a solution with respect to HYDROGEN ions; H+. It is related to acidity measurements in most cases by pH = log 1/2[1/(H+)], where (H+) is the hydrogen ion concentration in gram equivalents per liter of solution. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
A basic element found in nearly all organized tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes.
Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.
An anatomic severity scale based on the Abbreviated Injury Scale (AIS) and developed specifically to score multiple traumatic injuries. It has been used as a predictor of mortality.
General or unspecified injuries involving the leg.
Damage to any compartment of the lung caused by physical, chemical, or biological agents which characteristically elicit inflammatory reaction. These inflammatory reactions can either be acute and dominated by NEUTROPHILS, or chronic and dominated by LYMPHOCYTES and MACROPHAGES.
Damage or trauma inflicted to the eye by external means. The concept includes both surface injuries and intraocular injuries.
A condition of lung damage that is characterized by bilateral pulmonary infiltrates (PULMONARY EDEMA) rich in NEUTROPHILS, and in the absence of clinical HEART FAILURE. This can represent a spectrum of pulmonary lesions, endothelial and epithelial, due to numerous factors (physical, chemical, or biological).
General or unspecified injuries to the neck. It includes injuries to the skin, muscles, and other soft tissues of the neck.
Abrupt reduction in kidney function. Acute kidney injury encompasses the entire spectrum of the syndrome including acute kidney failure; ACUTE KIDNEY TUBULAR NECROSIS; and other less severe conditions.
General or unspecified injuries involving organs in the abdominal cavity.
General or unspecified injuries involving the arm.
Injuries resulting when a person is struck by particles impelled with violent force from an explosion. Blast causes pulmonary concussion and hemorrhage, laceration of other thoracic and abdominal viscera, ruptured ear drums, and minor effects in the central nervous system. (From Dorland, 27th ed)
General or unspecified injuries to the hand.
General or unspecified injuries to the chest area.
Injuries involving the vertebral column.
Injuries to the knee or the knee joint.
Damage to the MYOCARDIUM resulting from MYOCARDIAL REPERFUSION (restoration of blood flow to ischemic areas of the HEART.) Reperfusion takes place when there is spontaneous thrombolysis, THROMBOLYTIC THERAPY, collateral flow from other coronary vascular beds, or reversal of vasospasm.
Classification system for assessing impact injury severity developed and published by the American Association for Automotive Medicine. It is the system of choice for coding single injuries and is the foundation for methods assessing multiple injuries or for assessing cumulative effects of more than one injury. These include Maximum AIS (MAIS), Injury Severity Score (ISS), and Probability of Death Score (PODS).
General or unspecified injuries to the heart.
General or unspecified injuries to the soft tissue or bony portions of the face.
Injuries of tissue other than bone. The concept is usually general and does not customarily refer to internal organs or viscera. It is meaningful with reference to regions or organs where soft tissue (muscle, fat, skin) should be differentiated from bones or bone tissue, as "soft tissue injuries of the hand".
Traumatic injuries to the cranium where the integrity of the skull is not compromised and no bone fragments or other objects penetrate the skull and dura mater. This frequently results in mechanical injury being transmitted to intracranial structures which may produce traumatic brain injuries, hemorrhage, or cranial nerve injury. (From Rowland, Merritt's Textbook of Neurology, 9th ed, p417)
General or unspecified injuries to the posterior part of the trunk. It includes injuries to the muscles of the back.
Traumatic injuries involving the cranium and intracranial structures (i.e., BRAIN; CRANIAL NERVES; MENINGES; and other structures). Injuries may be classified by whether or not the skull is penetrated (i.e., penetrating vs. nonpenetrating) or whether there is an associated hemorrhage.
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.
Injuries to the PERIPHERAL NERVES.
A relatively common sequela of blunt head injury, characterized by a global disruption of axons throughout the brain. Associated clinical features may include NEUROBEHAVIORAL MANIFESTATIONS; PERSISTENT VEGETATIVE STATE; DEMENTIA; and other disorders.
A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug metabolites, and chemicals from the environment.
Injuries sustained from incidents in the course of work-related activities.
Damages to the CAROTID ARTERIES caused either by blunt force or penetrating trauma, such as CRANIOCEREBRAL TRAUMA; THORACIC INJURIES; and NECK INJURIES. Damaged carotid arteries can lead to CAROTID ARTERY THROMBOSIS; CAROTID-CAVERNOUS SINUS FISTULA; pseudoaneurysm formation; and INTERNAL CAROTID ARTERY DISSECTION. (From Am J Forensic Med Pathol 1997, 18:251; J Trauma 1994, 37:473)
Harm or hurt to the ankle or ankle joint usually inflicted by an external source.
Injuries caused by impact with a blunt object where there is no penetration of the skin.
Injuries to blood vessels caused by laceration, contusion, puncture, or crush and other types of injuries. Symptoms vary by site and mode of injuries and may include bleeding, bruising, swelling, pain, and numbness. It does not include injuries secondary to pathologic function or diseases such as ATHEROSCLEROSIS.
Systems for assessing, classifying, and coding injuries. These systems are used in medical records, surveillance systems, and state and national registries to aid in the collection and reporting of trauma.
Accidents on streets, roads, and highways involving drivers, passengers, pedestrians, or vehicles. Traffic accidents refer to AUTOMOBILES (passenger cars, buses, and trucks), BICYCLING, and MOTORCYCLES but not OFF-ROAD MOTOR VEHICLES; RAILROADS nor snowmobiles.
Wounds caused by objects penetrating the skin.
General or unspecified injuries involving the fingers.
Injuries to tissues caused by contact with heat, steam, chemicals (BURNS, CHEMICAL), electricity (BURNS, ELECTRIC), or the like.
General or unspecified injuries involving the foot.
Unforeseen occurrences, especially injuries in the course of work-related activities.
Deeply perforating or puncturing type intraocular injuries.
Hyperextension injury to the neck, often the result of being struck from behind by a fast-moving vehicle, in an automobile accident. (From Segen, The Dictionary of Modern Medicine, 1992)
Injuries resulting in hemorrhage, usually manifested in the skin.
Penetrating stab wounds caused by needles. They are of special concern to health care workers since such injuries put them at risk for developing infectious disease.
Pulmonary injury following the breathing in of toxic smoke from burning materials such as plastics, synthetics, building materials, etc. This injury is the most frequent cause of death in burn patients.
Renewal or physiological repair of damaged nerve tissue.
Disruption of structural continuity of the body as a result of the discharge of firearms.
Injuries caused by electric currents. The concept excludes electric burns (BURNS, ELECTRIC), but includes accidental electrocution and electric shock.
Head injuries which feature compromise of the skull and dura mater. These may result from gunshot wounds (WOUNDS, GUNSHOT), stab wounds (WOUNDS, STAB), and other forms of trauma.
A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain.
Multiple physical insults or injuries occurring simultaneously.
A method used to study the lateral movement of MEMBRANE PROTEINS and LIPIDS. A small area of a cell membrane is bleached by laser light and the amount of time necessary for unbleached fluorescent marker-tagged proteins to diffuse back into the bleached site is a measurement of the cell membrane's fluidity. The diffusion coefficient of a protein or lipid in the membrane can be calculated from the data. (From Segen, Current Med Talk, 1995).
A game in which a round inflated ball is advanced by kicking or propelling with any part of the body except the hands or arms. The object of the game is to place the ball in opposite goals.
A collective term for muscle and ligament injuries without dislocation or fracture. A sprain is a joint injury in which some of the fibers of a supporting ligament are ruptured but the continuity of the ligament remains intact. A strain is an overstretching or overexertion of some part of the musculature.
Injuries to the fibrous cords of connective tissue which attach muscles to bones or other structures.
Traumatic or other damage to teeth including fractures (TOOTH FRACTURES) or displacements (TOOTH LUXATION).
Conditions characterized by persistent brain damage or dysfunction as sequelae of cranial trauma. This disorder may result from DIFFUSE AXONAL INJURY; INTRACRANIAL HEMORRHAGES; BRAIN EDEMA; and other conditions. Clinical features may include DEMENTIA; focal neurologic deficits; PERSISTENT VEGETATIVE STATE; AKINETIC MUTISM; or COMA.
Efforts and designs to reduce the incidence of unexpected undesirable events in various environments and situations.
Lung damage that is caused by the adverse effects of PULMONARY VENTILATOR usage. The high frequency and tidal volumes produced by a mechanical ventilator can cause alveolar disruption and PULMONARY EDEMA.
Injuries to the wrist or the wrist joint.
Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood.
Body organ that filters blood for the secretion of URINE and that regulates ion concentrations.
Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.
A hypoperfusion of the BLOOD through an organ or tissue caused by a PATHOLOGIC CONSTRICTION or obstruction of its BLOOD VESSELS, or an absence of BLOOD CIRCULATION.
A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.
Penetrating wounds caused by a pointed object.
A competitive team sport played on a rectangular field. This is the American or Canadian version of the game and also includes the form known as rugby. It does not include non-North American football (= SOCCER).
The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.
Injuries to the optic nerve induced by a trauma to the face or head. These may occur with closed or penetrating injuries. Relatively minor compression of the superior aspect of orbit may also result in trauma to the optic nerve. Clinical manifestations may include visual loss, PAPILLEDEMA, and an afferent pupillary defect.
A statistical technique that isolates and assesses the contributions of categorical independent variables to variation in the mean of a continuous dependent variable.
A syndrome characterized by progressive life-threatening RESPIRATORY INSUFFICIENCY in the absence of known LUNG DISEASES, usually following a systemic insult such as surgery or major TRAUMA.
General or unspecified injuries involving the face and jaw (either upper, lower, or both).
Experimentally produced harmful effects of ionizing or non-ionizing RADIATION in CHORDATA animals.
A scale that assesses the response to stimuli in patients with craniocerebral injuries. The parameters are eye opening, motor response, and verbal response.
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
Drugs intended to prevent damage to the brain or spinal cord from ischemia, stroke, convulsions, or trauma. Some must be administered before the event, but others may be effective for some time after. They act by a variety of mechanisms, but often directly or indirectly minimize the damage produced by endogenous excitatory amino acids.
A disturbance in the prooxidant-antioxidant balance in favor of the former, leading to potential damage. Indicators of oxidative stress include damaged DNA bases, protein oxidation products, and lipid peroxidation products (Sies, Oxidative Stress, 1991, pxv-xvi).
Hospital unit providing continuous monitoring of the patient following anesthesia.
A nonspecific term used to describe transient alterations or loss of consciousness following closed head injuries. The duration of UNCONSCIOUSNESS generally lasts a few seconds, but may persist for several hours. Concussions may be classified as mild, intermediate, and severe. Prolonged periods of unconsciousness (often defined as greater than 6 hours in duration) may be referred to as post-traumatic coma (COMA, POST-HEAD INJURY). (From Rowland, Merritt's Textbook of Neurology, 9th ed, p418)
Falls due to slipping or tripping which may result in injury.
One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.
The muscle tissue of the HEART. It is composed of striated, involuntary muscle cells (MYOCYTES, CARDIAC) connected to form the contractile pump to generate blood flow.
Mechanical or anoxic trauma incurred by the infant during labor or delivery.
A disorder characterized by a reduction of oxygen in the blood combined with reduced blood flow (ISCHEMIA) to the brain from a localized obstruction of a cerebral artery or from systemic hypoperfusion. Prolonged hypoxia-ischemia is associated with ISCHEMIC ATTACK, TRANSIENT; BRAIN INFARCTION; BRAIN EDEMA; COMA; and other conditions.
A cylindrical column of tissue that lies within the vertebral canal. It is composed of WHITE MATTER and GRAY MATTER.
A subtype of striated muscle, attached by TENDONS to the SKELETON. Skeletal muscles are innervated and their movement can be consciously controlled. They are also called voluntary muscles.
A snow sport which uses skis to glide over the snow. It does not include water-skiing.
A hemeprotein from leukocytes. Deficiency of this enzyme leads to a hereditary disorder coupled with disseminated moniliasis. It catalyzes the conversion of a donor and peroxide to an oxidized donor and water. EC 1.11.1.7.
Traumatic injuries to the brain, cranial nerves, spinal cord, autonomic nervous system, or neuromuscular system, including iatrogenic injuries induced by surgical procedures.
Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques.
The pathological process occurring in cells that are dying from irreparable injuries. It is caused by the progressive, uncontrolled action of degradative ENZYMES, leading to MITOCHONDRIAL SWELLING, nuclear flocculation, and cell lysis. It is distinct it from APOPTOSIS, which is a normal, regulated cellular process.
Restoration of integrity to traumatized tissue.
Severe or complete loss of motor function in all four limbs which may result from BRAIN DISEASES; SPINAL CORD DISEASES; PERIPHERAL NERVOUS SYSTEM DISEASES; NEUROMUSCULAR DISEASES; or rarely MUSCULAR DISEASES. The locked-in syndrome is characterized by quadriplegia in combination with cranial muscle paralysis. Consciousness is spared and the only retained voluntary motor activity may be limited eye movements. This condition is usually caused by a lesion in the upper BRAIN STEM which injures the descending cortico-spinal and cortico-bulbar tracts.
An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.
Breaks in bones.
Severe or complete loss of motor function in the lower extremities and lower portions of the trunk. This condition is most often associated with SPINAL CORD DISEASES, although BRAIN DISEASES; PERIPHERAL NERVOUS SYSTEM DISEASES; NEUROMUSCULAR DISEASES; and MUSCULAR DISEASES may also cause bilateral leg weakness.
Harmful effects of non-experimental exposure to ionizing or non-ionizing radiation in VERTEBRATES.
Nerve fibers that are capable of rapidly conducting impulses away from the neuron cell body.
A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.
The first seven VERTEBRAE of the SPINAL COLUMN, which correspond to the VERTEBRAE of the NECK.
Treatment of muscles and nerves under pressure as a result of crush injuries.
General or unspecified injuries involving the hip.
The physiological renewal, repair, or replacement of tissue.
Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.
The basic cellular units of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the NERVOUS SYSTEM.
Dysfunction of one or more cranial nerves causally related to a traumatic injury. Penetrating and nonpenetrating CRANIOCEREBRAL TRAUMA; NECK INJURIES; and trauma to the facial region are conditions associated with cranial nerve injuries.
A process involving chance used in therapeutic trials or other research endeavor for allocating experimental subjects, human or animal, between treatment and control groups, or among treatment groups. It may also apply to experiments on inanimate objects.
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Personal devices for protection of heads from impact, penetration from falling and flying objects, and from limited electric shock and burn.
Specialized hospital facilities which provide diagnostic and therapeutic services for trauma patients.
Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.
The number of new cases of a given disease during a given period in a specified population. It also is used for the rate at which new events occur in a defined population. It is differentiated from PREVALENCE, which refers to all cases, new or old, in the population at a given time.
Equipment required for engaging in a sport (such as balls, bats, rackets, skis, skates, ropes, weights) and devices for the protection of athletes during their performance (such as masks, gloves, mouth pieces).
Traumatic injuries to the facial nerve. This may result in FACIAL PARALYSIS, decreased lacrimation and salivation, and loss of taste sensation in the anterior tongue. The nerve may regenerate and reform its original pattern of innervation, or regenerate aberrantly, resulting in inappropriate lacrimation in response to gustatory stimuli (e.g., "crocodile tears") and other syndromes.
Granular leukocytes having a nucleus with three to five lobes connected by slender threads of chromatin, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes.
The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.
Non-human animals, selected because of specific characteristics, for use in experimental research, teaching, or testing.
An enzyme that catalyzes the conversion of L-alanine and 2-oxoglutarate to pyruvate and L-glutamate. (From Enzyme Nomenclature, 1992) EC 2.6.1.2.
Torn, ragged, mangled wounds.
An element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration.
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
A tetrameric enzyme that, along with the coenzyme NAD+, catalyzes the interconversion of LACTATE and PYRUVATE. In vertebrates, genes for three different subunits (LDH-A, LDH-B and LDH-C) exist.
A nerve which originates in the lumbar and sacral spinal cord (L4 to S3) and supplies motor and sensory innervation to the lower extremity. The sciatic nerve, which is the main continuation of the sacral plexus, is the largest nerve in the body. It has two major branches, the TIBIAL NERVE and the PERONEAL NERVE.
The span of viability of a cell characterized by the capacity to perform certain functions such as metabolism, growth, reproduction, some form of responsiveness, and adaptability.
Injuries to the part of the upper limb of the body between the wrist and elbow.
A general term most often used to describe severe or complete loss of muscle strength due to motor system disease from the level of the cerebral cortex to the muscle fiber. This term may also occasionally refer to a loss of sensory function. (From Adams et al., Principles of Neurology, 6th ed, p45)
A technique in which tissue is rendered resistant to the deleterious effects of prolonged ISCHEMIA and REPERFUSION by prior exposure to brief, repeated periods of vascular occlusion. (Am J Physiol 1995 May;268(5 Pt 2):H2063-7, Abstract)
The period of recovery following an illness.
The statistical reproducibility of measurements (often in a clinical context), including the testing of instrumentation or techniques to obtain reproducible results. The concept includes reproducibility of physiological measurements, which may be used to develop rules to assess probability or prognosis, or response to a stimulus; reproducibility of occurrence of a condition; and reproducibility of experimental results.
Levels within a diagnostic group which are established by various measurement criteria applied to the seriousness of a patient's disorder.
Refers to animals in the period of time just after birth.
The MUSCLES, bones (BONE AND BONES), and CARTILAGE of the body.
Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
Traumatic injuries to the HYPOGLOSSAL NERVE.
Laboratory mice that have been produced from a genetically manipulated EGG or EMBRYO, MAMMALIAN.
Enzymes of the transferase class that catalyze the conversion of L-aspartate and 2-ketoglutarate to oxaloacetate and L-glutamate. EC 2.6.1.1.
Pathological processes of the LIVER.
Hospital department responsible for the administration and provision of immediate medical or surgical care to the emergency patient.
Either of two extremities of four-footed non-primate land animals. It usually consists of a FEMUR; TIBIA; and FIBULA; tarsals; METATARSALS; and TOES. (From Storer et al., General Zoology, 6th ed, p73)
The physical activity of a human or an animal as a behavioral phenomenon.
The process by which chemical compounds provide protection to cells against harmful agents.
Any adverse condition in a patient occurring as the result of treatment by a physician, surgeon, or other health professional, especially infections acquired by a patient during the course of treatment.
The number of CELLS of a specific kind, usually measured per unit volume or area of sample.
A disorder of cardiac function caused by insufficient blood flow to the muscle tissue of the heart. The decreased blood flow may be due to narrowing of the coronary arteries (CORONARY ARTERY DISEASE), to obstruction by a thrombus (CORONARY THROMBOSIS), or less commonly, to diffuse narrowing of arterioles and other small vessels within the heart. Severe interruption of the blood supply to the myocardial tissue may result in necrosis of cardiac muscle (MYOCARDIAL INFARCTION).
An abnormal increase in the amount of oxygen in the tissues and organs.
Devices designed to provide personal protection against injury to individuals exposed to hazards in industry, sports, aviation, or daily activities.
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.
Any of various animals that constitute the family Suidae and comprise stout-bodied, short-legged omnivorous mammals with thick skin, usually covered with coarse bristles, a rather long mobile snout, and small tail. Included are the genera Babyrousa, Phacochoerus (wart hogs), and Sus, the latter containing the domestic pig (see SUS SCROFA).
The diffusion or accumulation of neutrophils in tissues or cells in response to a wide variety of substances released at the sites of inflammatory reactions.
Disease or damage involving the SCIATIC NERVE, which divides into the PERONEAL NERVE and TIBIAL NERVE (see also PERONEAL NEUROPATHIES and TIBIAL NEUROPATHY). Clinical manifestations may include SCIATICA or pain localized to the hip, PARESIS or PARALYSIS of posterior thigh muscles and muscles innervated by the peroneal and tibial nerves, and sensory loss involving the lateral and posterior thigh, posterior and lateral leg, and sole of the foot. The sciatic nerve may be affected by trauma; ISCHEMIA; COLLAGEN DISEASES; and other conditions. (From Adams et al., Principles of Neurology, 6th ed, p1363)
Long convoluted tubules in the nephrons. They collect filtrate from blood passing through the KIDNEY GLOMERULUS and process this filtrate into URINE. Each renal tubule consists of a BOWMAN CAPSULE; PROXIMAL KIDNEY TUBULE; LOOP OF HENLE; DISTAL KIDNEY TUBULE; and KIDNEY COLLECTING DUCT leading to the central cavity of the kidney (KIDNEY PELVIS) that connects to the URETER.
Pathological processes involving any part of the LUNG.
Two-wheeled, engine-driven vehicles.
A group of pathological conditions characterized by sudden, non-convulsive loss of neurological function due to BRAIN ISCHEMIA or INTRACRANIAL HEMORRHAGES. Stroke is classified by the type of tissue NECROSIS, such as the anatomic location, vasculature involved, etiology, age of the affected individual, and hemorrhagic vs. non-hemorrhagic nature. (From Adams et al., Principles of Neurology, 6th ed, pp777-810)
Serum glycoprotein produced by activated MACROPHAGES and other mammalian MONONUCLEAR LEUKOCYTES. It has necrotizing activity against tumor cell lines and increases ability to reject tumor transplants. Also known as TNF-alpha, it is only 30% homologous to TNF-beta (LYMPHOTOXIN), but they share TNF RECEPTORS.
The termination of the cell's ability to carry out vital functions such as metabolism, growth, reproduction, responsiveness, and adaptability.
The thin layer of GRAY MATTER on the surface of the CEREBRAL HEMISPHERES that develops from the TELENCEPHALON and folds into gyri and sulchi. It reaches its highest development in humans and is responsible for intellectual faculties and higher mental functions.
Application of a ligature to tie a vessel or strangulate a part.
Age as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or the effect of a circumstance. It is used with human or animal concepts but should be differentiated from AGING, a physiological process, and TIME FACTORS which refers only to the passage of time.
A strong ligament of the knee that originates from the posteromedial portion of the lateral condyle of the femur, passes anteriorly and inferiorly between the condyles, and attaches to the depression in front of the intercondylar eminence of the tibia.
Use or insertion of a tubular device into a duct, blood vessel, hollow organ, or body cavity for injecting or withdrawing fluids for diagnostic or therapeutic purposes. It differs from INTUBATION in that the tube here is used to restore or maintain patency in obstructions.
Relatively complete absence of oxygen in one or more tissues.
The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)
Tomography using x-ray transmission and a computer algorithm to reconstruct the image.
Forcible or traumatic tear or break of an organ or other soft part of the body.
Pathologic processes that affect patients after a surgical procedure. They may or may not be related to the disease for which the surgery was done, and they may or may not be direct results of the surgery.
A game in which two parties of players provided with curved or hooked sticks seek to drive a ball or puck through opposite goals. This applies to either ice hockey or field hockey.
Washing liquid obtained from irrigation of the lung, including the BRONCHI and the PULMONARY ALVEOLI. It is generally used to assess biochemical, inflammatory, or infection status of the lung.
Freedom from exposure to danger and protection from the occurrence or risk of injury or loss. It suggests optimal precautions in the workplace, on the street, in the home, etc., and includes personal safety as well as the safety of property.
The innermost layer of an artery or vein, made up of one layer of endothelial cells and supported by an internal elastic lamina.
Synthetic or natural substances which are given to prevent a disease or disorder or are used in the process of treating a disease or injury due to a poisonous agent.
Pathological processes of the KIDNEY or its component tissues.
The dialdehyde of malonic acid.
Harmful and painful condition caused by overuse or overexertion of some part of the musculoskeletal system, often resulting from work-related physical activities. It is characterized by inflammation, pain, or dysfunction of the involved joints, bones, ligaments, and nerves.
Excessive accumulation of extravascular fluid in the lung, an indication of a serious underlying disease or disorder. Pulmonary edema prevents efficient PULMONARY GAS EXCHANGE in the PULMONARY ALVEOLI, and can be life-threatening.
Using ice skates, roller skates, or skateboards in racing or other competition or for recreation.
A positive regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins.
... s can be classified by depth, mechanism of injury, extent, and associated injuries. The most commonly used classification ... Metabolism in burn victims proceeds at a higher than normal speed due to whole body process and rapid fatty acid substrate ... Enteral feeding a day after resuscitation is required to reduce risk of infection, recovery time, non-infectious complications ... Controlling blood glucose levels can have an impact on liver function and survival. ...
Neuropraxia: no wallerian degeneration and complete and rapid recovery of function. Axonotmesis: wallerian degeneration and ... Neurotmesis: this type of injury involves the endoneurium with wallerian degeneration. Recovery is difficult. There are several ... facial nerve injury, injury to the other cranial nerve, disordered vestibular compensation. Gopen Q (15 December 2013). ... Uncontrolled bleeding or injury to I.A.C. is most serious complication during surgery. For patient with total hearing loss, ...
Since this injury is very painful, recovery is usually very slow. When the person is without pain, sports massage and range-of- ... Signs and symptoms include immediate pain, bruising and swelling, obvious weakness, spasms and a rapid decline in the hip / leg ... function, resulting in a decreased range of motion. Rest, Ice, Compression and Elevation (RICE) are standard treatments in the ... The injury results from the crushing of soft tissue between a hard object and the iliac crest. Contact sports are a common ...
Rapid sideline testing using short neuropsychological tests that assess attention and memory function have been proven useful ... Prevention of mild traumatic brain injury involves taking general measures to prevent traumatic brain injury, such as wearing ... It assures players who experience a concussion have complete cognitive and clinical recovery before returning to play. Best ... which is associated with a high injury rate, may also prevent concussions. Prevention of undiagnosed and repeat injury is of ...
"Transplantation of Specific Human Astrocytes Promotes Functional Recovery after spinal Cord Injury". PLoS ONE. 6 (3): e17328. ... More recently, the function of astrocytes has been reconsidered, and they are now thought to play a number of active roles in ... Modulation of synaptic transmission: In the supraoptic nucleus of the hypothalamus, rapid changes in astrocyte morphology have ... The function and availability of EAAT2 is modulated by TAAR1, an intracellular receptor in human astrocytes.[67] ...
After stroke or other forms of brain injury, reorganisation of this sort can help the process of recovery, as other parts of ... The changes in organisation can be remarkably rapid, even in adults. Blakemore has shown that the visual parts of the human ... the brain take over the function of the damaged part. Blakemore's recent work has emphasized the variety of molecular ... the International Brain Injury Association, Headway, Sense (The National Deafblind & Rubella Association), the Louise T Blouin ...
There are instances when function is not completely restored until four months after the instance of injury. The recovery ... there must be a complete and relatively rapid recovery of motor and sensory function once nerve conduction has been restored; ... Recovery begins within two to three weeks after the injury occurs, and it is complete within six to eight weeks. ... Since neurapraxia is the least serious form of peripheral nerve injury, recovery and treatment are not extensive. Once the ...
Recovery of visual function is expected within 10 weeks. However, attacks may lead to permanent axonal loss and thinning of the ... The optic nerve can be damaged when exposed to direct or indirect injury. Direct optic nerve injuries are caused by trauma to ... While vision loss may be rapid, progression to blindness is unusual. These patients tend to have blind spots in the center of ... The most common site of injury of the optic nerve is the intracanalicular portion of the nerve. Deceleration injuries from ...
... so recovery does not involve actual regeneration. There is frequently greater involvement of motor than sensory function with ... Electrically, the nerve shows rapid and complete degeneration, with loss of voluntary motor units. Regeneration of the motor ... Neurapraxia is the least severe form of nerve injury, with complete recovery. In this case, the axon remains intact, but there ... Nerve injury is injury to nervous tissue. There is no single classification system that can describe all the many variations of ...
... and survivors many not regain the same pre-injury function. Subdural and epidural hematomas are serious injuries and recovery ... The most crutial aspect for recovery in patients with severe hematomas is rapid diagnosis and appropriate treatment. Once the ... Outcomes vary from minor injuries that require short recovery times to severe injuries that can lead to death. Short-term ... In hockey, traumatic brain injuries constitute 10%-15% of all head injuries. With the high percent of injuries being traumatic ...
In the US, college rugby has much higher injury rates than college football. Rugby union has similar injury types to American ... More severe impacts, or the forces associated with rapid acceleration, may not be absorbed by this cushion. Concussion may be ... It is short-lived impairment of neurological function, the brains ability to process information, which can be resolved in ... or return to play before a complete recovery from a previous concussion. This is a result from brain swelling, from vascular ...
Neurobehavioral Recovery from Head Injury, 217-218. New York: Oxford University Press. ... a diffuse axonal injury,[12] or childhood brain damage (e.g., shaken baby syndrome).[12] In cases of sudden rapid acceleration ... Squire, L. R. (1986). Memory functions as affected by electroconvulsive therapy, Annals of the New York Academy of Science, 462 ... Traumatic brain injury (TBI) or post-traumatic amnesia[edit]. Traumatic brain injury (TBI), also known as post-traumatic ...
Recovery time ranges between one and two years or longer. A week or so after the occurrence of the injury, the athlete is ... Ellison A, Berg E. Embryology, anatomy, and function of the anterior cruciate ligament. Orthop Clin North Am 1985;16:3-14. ... Patients involved in sports requiring significant cutting, pivoting, twisting or rapid acceleration or deceleration may not be ... previous knee injury, other injuries sustained, leg alignment and graft choice. Occasionally, stimulation of the body's natural ...
"Transplantation of specific human astrocytes promotes functional recovery after spinal cord injury". PLOS ONE. 6 (3): e17328. ... The function and availability of EAAT2 is modulated by TAAR1, an intracellular receptor in human astrocytes. GluR type: these ... Modulation of synaptic transmission: In the supraoptic nucleus of the hypothalamus, rapid changes in astrocyte morphology have ... They perform many functions, including biochemical support of endothelial cells that form the blood-brain barrier, provision of ...
Unrelieved pain can cause alkalosis and hypoxemia that result from rapid, shallow breathing. This shallow breathing can lead to ... Neuropathic pain is associated with nerve injuries or abnormal sensitivities to touch or contact. Though neuropathic pain is ... Peripheral neuropathic pain refers to disturbance in the function of peripheral nerves while central neuropathic pain refers to ... Other consequences include extended hospital stays, high re-admission rates and longer recovery. Examples of harmful ...
... military operations brain injuries were classified mTBI. In response, the DoD pursued new technologies capable of rapid, ... This device functions as a dry sensor at a size no larger than a Bluetooth ear piece.[123] ... Accurately differentiating between mTBI and PTSD can significantly increase positive recovery outcomes for patients especially ... "Study: EEG can help tell apart PTSD, mild traumatic brain injury". www.research.va.gov. Retrieved 2019-10-09.. ...
... that led to 620 deaths and 200 injuries. An engine may fail to function because of fuel starvation (e.g. British Airways Flight ... This can lead to an accident if the aircraft is too low to effect a recovery before ground contact. Between 1964 and 1985, wind ... Strong outflow from thunderstorms causes rapid changes in the three-dimensional wind velocity just above ground level. ... Beck, L. F.; Dellinger, A. M.; O'neil, M. E. (2007). "Motor vehicle crash injury rates by mode of travel, United States: using ...
... there is generally a more rapid recovery with less blood loss. However, if the spinal column is unstable and fusion is required ... Potential complications include bleeding, infection, blood clots, nerve injury, and spinal fluid leak. Most commonly, a ... most patients who had undergone a lumbar laminectomy recovered normal function within one year of their operation. Back surgery ... For some people, recovery can take weeks or months and may require long-term occupational and physical therapy. Surgery does ...
Fischer FR, Peduzzi JD (2007). "Functional Recovery in Rats With Chronic Spinal Cord Injuries After Exposure to an Enriched ... Koepsell TD, Kurland BF, Harel O, Johnson EA, Zhou XH, Kukull WA (May 2008). "Education, cognitive function, and severity of ... "Environmental enrichment restores neurogenesis and rapid acquisition in aged rats". Neurobiology of Aging. 34 (1): 263-74. doi: ... A 2008 study found that environmental enrichment was significant in aiding recovery of motor coordination and some recovery of ...
Upon retinal injury, gliosis of these cells occurs, functioning to repair damage, but often having harmful consequences in the ... Release of excitotoxic glutamate Hindrance of functional recovery and worsening of clinical signs Microglia, another type of ... allowing for a rapid response to inflammatory signals and prompt destruction of infectious agents before sensitive neural ... Typically, the first response to injury is the migration of macrophages and local microglia to the injury site. This process, ...
Most children with a buckle wrist fracture experience a full recovery to their previous level of wrist function and do not have ... Risk of injury increases in those with osteoporosis. Common injuries associated with distal radius fractures are interosseous ... Symptoms include pain, bruising, and rapid-onset swelling. The wrist may be broken for life. The ulna bone may also be broken. ... Another author, Pouteau, suggested the common mechanism of injury which leads to this type of fractures - injury to the wrist ...
The primary goals of stroke management are to reduce brain injury and promote maximum patient recovery. Rapid detection and ... if there is some recovery of hand function, there is a 70% chance of making a full or good recovery. He reported that most ... are key predictors of stroke recovery outcomes. Responses to treatment and overall recovery of function are highly dependent on ... The quality of evidence regarding the effects of MT on the recovery of lower limb functions is still low, with only one study ...
Post-anesthesia care unit (PACU): Also known as the post-operative recovery unit, or recovery room, the PACU provides immediate ... This allows for rapid intervention should a patient's condition deteriorate whilst a member of staff is not immediately at the ... Despite calls for all ICUs to function as closed-model units with intensivists as the primary physician of record, evidence ... Intensive care units cater to patients with severe or life-threatening illnesses and injuries, which require constant care, ...
Mechanisms of injury[edit]. The two main causes are injury (acute) and degeneration (chronic and cumulative), and the ... Recovery can take as long as three-six months, with a sling being worn for the first one-six weeks.[53] ... Patients usually regain function in their shoulders, and experience less pain, following surgery. For some, however, the joint ... rapid stiffening and an increase in pain can result if sufficient stretching has not been implemented. ...
... it may enable the animal's full or partial recovery from the injury. Studies in children with early childhood brain injuries ... as they had before the injury. These researchers compared flies with functioning versus impaired proprioception - the body's ... Duncan, GE; Paul, IA; Harden, TK; Mueller, RA; Stumpf, WE; Breese, GR (August 1985). "Rapid down regulation of beta adrenergic ... "Recovery of locomotion after injury in Drosophila melanogaster depends on proprioception". The Journal of Experimental Biology ...
... wrist injuries, myelopathy, low back injuries and lower leg and ankle injuries. Repetitive use injuries are a result of rapid ... Recovery is enhanced by doing activities that make an individual feel better. Recovery from an injury also consists of ... once injured tendons and ligaments detrimentally impact motor functions. Injuries associated with repetitive-use activities ... Sustaining a secondary injury has a large risk whilst recovering from an initial injury. Injuries often limit physical activity ...
A stroke is the rapid decline of brain function due to a disturbance in the supply of blood to the brain. This can be due to ... Endothelial cell injury[edit]. Any inflammatory process, such as trauma, surgery or infection, can cause damage to the ... The majority of persons affected make a full recovery. The mortality rate is 4.3%.[4] ... Endothelial injury is almost invariably involved in the formation of thrombi in arteries, as high rates of blood flow normally ...
A stroke is the rapid decline of brain function due to a disturbance in the supply of blood to the brain. This can be due to ... Targeting ischemia/reperfusion injury[edit]. Main article: Reperfusion injury. With reperfusion comes ischemia/reperfusion (IR ... The majority of persons affected make a full recovery. The mortality rate is 4.3%.[4] ... Endothelial cell injury[edit]. Any inflammatory process, such as trauma, surgery or infection, can cause damage to the ...
Even when the change in pressure causes no immediate symptoms, rapid pressure change can cause permanent bone injury called ... Transient episodes of severe neurological incapacitation with rapid spontaneous recovery shortly after a dive may be attributed ... A loss of strength or function is likely to be a medical emergency. A loss of feeling that lasts more than a minute or two ... previous injury - there is some indication that recent joint or limb injuries may predispose individuals to developing ...
... later making a full recovery. Hospital officials confirmed that tests carried out after the patient's recovery were positive ... NDM-1 functions through two zinc ions present in the active site that cause hydrolysis of the beta-lactams, rendering them ... He was hospitalised with a major leg injury and then repatriated to Belgium, but he was already infected". In another case, an ... "rapid spread of NDM-1 with potentially serious consequences". As of June 2010[update], there were three reported cases of ...
... in the Journal of Neurotrauma finds that rapid air evacuation of wounded personnel suffering from traumatic brain injury - ... 2 April Syrian Air Force aircraft bomb Nusra Front forces in southern Syria after they capture the last functioning border ... previously assumed to have increased their chances of survival and recovery - leads to more inflammation of the brain and could ... No one is killed, but 20 of the people on board suffer injuries. Al-Qaeda in the Arabian Peninsula forces seize Riyan Airport ...
Most fetal birth injuries resolve without long term harm, but brachial plexus injury may lead to Erb's palsy or Klumpke's ... The most severe symptoms last from two to 12 weeks, and recovery takes six months to a year. Five causes make up about 80 per ... some Maya women who work in agricultural fields of some rural communities will usually continue to work in a similar function ... a substantial degree of cervical effacement and more rapid cervical dilatation from 5 cm until full dilatation for first and ...
Recovery crews reported that no other debris or evidence of human remains had been discovered. The NTSB inspected the cargo ... Every flight attendant suffered some injury during the evacuation, ranging from scratches to a dislocated shoulder. Despite ... rapid decompression caused by a cargo door malfunction Turkish Airlines Flight 981 - explosive decompression caused by a cargo ... and not a problem inherent in the design or function of the aircraft's cargo door. Lee Campbell, a New Zealander returning home ...
Lepak, Jesse M.; Kraft, Clifford E., Weidel, Brian C. (March 2006). "Rapid food web recovery in response to removal of an ... This functions as an upward biological pump, reversing an earlier presumption that whales accelerate the loss of nutrients to ... They can cause injuries such as hemorrhaging of the lungs, and contusion and ulceration of the gastrointestinal tract. ... Initially, moving organisms, such as sharks and hagfish, scavenge soft tissue at a rapid rate over a period of months to as ...
There are a number of analytical techniques for the rapid measurement of BFR concentrations. X-ray fluorescence spectroscopy ... recycling and recovery targets for electrical goods and is part of a legislative initiative to solve the problem of huge ... which can fulfil its function only if it is part of that equipment, and which can be replaced only by the same specifically ... that is direct exposure to large amounts of toxic substances causing severe injury or death. The United States Environmental ...
Residual Functions) Regulations 1994 (S.I. 1994/2590) Scottish Milk Marketing Board (Residual Functions) Regulations 1994 (S.I ... 6) Order 1994 (S.I. 1994/700) Greater Manchester (Light Rapid Transit System) (Modification) Order 1994 (S.I. 1994/701) London ... Personal Injuries (Civilians) Amendment (No. 2) Scheme 1994 (S.I. 1994/2021) General Medical Council (Constitution of Fitness ... Self-Governing Schools Grant and Recovery (Scotland) Regulations 1994 (S.I. 1994/431) Hyde Park and The Regent's Park (Vehicle ...
... rapid recovery in pemphigus, according to a 2006 study), type 1 diabetes mellitus, Sjögren syndrome, anti-NMDA receptor ... Although the function of CD20 is unknown, it may play a role in Ca2+ influx across plasma membranes, maintaining intracellular ... Cardiac arrest Cytokine release syndrome Tumor lysis syndrome, causing acute kidney injury Infections Hepatitis B reactivation ... lymphocyte function-associated antigen). It elicits shedding of CD23. It downregulates the B cell receptor. It induces ...
Its purpose and function was "to insure competent underwater instruction and to reduce diving accidents through education." In ... The Cave Diving Group re-formed in 1946 and progress was rapid. Typical equipment at this time was a frogman rubber diving suit ... Training and emergency procedures such as the buddy system, buddy breathing, and scuba ditch and recovery were introduced and ... and to greater risks of serious injury or death. These risks may be reduced by appropriate skills, knowledge and experience, ...
... good global functioning and good psychosocial functioning. Stoffers, Jutta M.; Völlm, Birgit A.; Rücker, Gerta; Timmer, Antje; ... Specifically, DBT has been found to significantly reduce self-injury, suicidal behavior, impulsivity, self-rated anger and the ... Services, or individual goals, are increasingly based on a recovery model that supports and emphasizes an individual's personal ... as well as rapid changes in mood.[failed verification][unreliable medical source?] Individuals with BPD sometimes use mental ...
Cessna confirmed that the 162 entered a spin from cross-controlled, power-on stall, that the spin became flat and recovery was ... The test pilot parachuted to safety and suffered only minor injuries. The prototype had flown about 150 hours prior to the ... Flight data is presented on the G300 in a single, split-screen combination primary flight display and multi-function display. ... During aggressive spin testing, with power on and in a cross-controlled condition, the aircraft entered a "rapid and ...
No injuries were reported. After the incident, SpaceX decided not to repair and retest Mk1. Both Mk1 and Mk2 were retired and ... The upper stage of Starship is intended to function both as a second stage to reach orbital velocity on launches from Earth, ... Satellite delivery spacecraft: a vehicle able to transport and place spacecraft into orbit, or handle the in‑space recovery of ... Lower than expected pressure in the methane header tank following the rapid rotation caused inadequate final deceleration and a ...
Full recovery from appendectomies takes about four to six weeks but can be prolonged to up to eight weeks if the appendix had ... "WHO Disease and injury country estimates". World Health Organization. 2009. Archived from the original on 11 November 2020. ... The possibility of peritonitis is the reason why acute appendicitis warrants rapid evaluation and treatment. People with ... then progress to a regular diet when the intestines start to function correctly. Patients are recommended to sit upon the edge ...
"WHO Disease and injury country estimates". World Health Organization. 2009. Archived from the original on 2009-11-11. Retrieved ... "Men need to hear the story of ODU coach Jeff Jones' recovery from prostate cancer". The Virginian-Pilot. Retrieved 2019-08-27 ... This cell death is very rapid Greene ER, Huang S, Serhan CN, Panigrahy D (November 2011). "Regulation of inflammation in cancer ... Radiotherapy and surgery appear to result in similar outcomes with respect to bowel, erectile and urinary function after five ...
By the time day 5 muscle testing was completed, some recovery in function had likely occurred; however, a marked decrement ... High loads were placed on some leg muscles, especially the calf, and fatigue was so rapid that the device could not be used for ... The inference of these findings is that there is indeed a propensity for muscle injury secondary to the atrophic process that ... Postflight tests were conducted on recovery (landing) day and once more at 24 to 36 hours after recovery. During each test, ...
2009). "Systemic administration of an antagonist of the ATP-sensitive receptor P2X7 improves recovery after spinal cord injury ... Bradford, Marion M. (1976). "A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the ... clinical relevance and in vitro analysis of the function of the outer blood-retinal barrier. Developments in Ophthalmology. 42 ... "Blue M&Ms 'mend spinal injuries'". Telegraph. 2009-07-28. Retrieved 2010-01-19. "Blue Food Dye Treats Spine Injury in Rats". ...
Injuries to the genital areas can include swelling, lacerations, and bruising. Common genital injuries are anal injury, labial ... CADTH Rapid Response Reports. Ottawa (ON): Canadian Agency for Drugs and Technologies in Health. PMID 31219689. Chen, Melissa J ... Recovery from sexual assault is a complicated and controversial concept, but support groups, usually accessed by organizations ... and may experience difficulties with resuming their social life and with sexual functioning. People who have been raped are at ...
... rapid skeletal muscle breakdown) leading to acute kidney injury and the need for transient dialysis in the undiagnosed ... December 2019). "Vascular Changes in the Retina and Choroid of Patients With EPAS1 Gain-of-Function Mutation Syndrome". JAMA ... the chance of recovery or a recurrence. This is an extremely difficult question when it comes to pheochromcytoma, and the ... September 2012). "Somatic HIF2A gain-of-function mutations in paraganglioma with polycythemia". The New England Journal of ...
The Toxic Substances Control Act of 1976 mandated the EPA to protect the public from "unreasonable risk of injury to health or ... There is not enough knowledge about the potential risk of exposure while new nano material created at a rapid rate is ... They argue that "the inability to function as intended results from a series of legal, organizational, and political challenges ... Clean Water Act and the Resource Conservation and Recovery Act. Instead, like FIFRA (the Federal Insecticide, Fungicide, and ...
Rapid entry team: See FAST. Rapid intervention crew/group/team (RIC, RIG, or RIT): This is a standby crew whose purpose is to ... Becomes "recovery" if victims are not likely to be found alive. May be done in quick primary wave and more thorough secondary ... Hazard: a source of danger of personal injury or property damage; fire hazard refers to conditions that may result in fire or ... and equipped to perform certain operational functions. The firefighters in a company nearly always work on the same vehicle, ...
Features of Blade-Injuries to Bone Surfaces in Six Anglo-Saxon Skeletons from Eccles, Kent: BAR 211 Oxford, 1989. Loesche, W.J ... The rapid and dramatic increase in 13C after the adoption of maize agriculture attests to the change in the southeastern ... If there is not recovery from the stressor, no line will be formed. The stress hormone cortisol is deposited in hair as it ... Scott, J.H. (1957). "Muscle Growth and Function in Relation to Skeletal Morphology". American Journal of Physical Anthropology ...
Fowler, S. (1985). Recoveries, foreign retraps, returns and repeats: 1983-1984. Ontario Bird Banding no. 17:30-34. Frost, P. " ... As the intensity of her attacks increases, her kakking becomes more rapid and can attain a constant screaming quality. Females ... Kenward, R. E. (1982). Goshawk hunting behaviour, and range size as a function of food and habitat availability. The Journal of ... injuries and blood loss. Research has indicated that attacks on humans are mostly done by adult females (more than 80% of the ...
Its function is to encode experiences for storage as long-term memories elsewhere in the brain. In 2004 Thomas DeMarse at the ... There has been rapid development in BCIs since the mid-1990s. Several groups have been able to capture complex brain motor ... In their spinal cord injury research study, a person with paraplegia was able to operate a BCI-robotic gait orthosis to regain ... So far, BCIs for motor recovery have relied on the EEG to measure the patient's motor imagery. However, studies have also used ...
... and various injuries. Recoveries have been attributed to many techniques commonly classified as faith healing. It can involve ... Grand Rapids, MI: Baker Book House. ISBN 978-0801025211.CS1 maint: ref duplicates default (link) Eddy, Mary Baker (1910) [1875 ... not through any mysterious or numinous function, but by the power of their own belief that they would be healed. In both cases ... Grand Rapids, MI: Revell. ISBN 978-0800757397. Carson, Don (1987). Showing the Spirit: A Theological Exposition of 1 ...
She had frequent migraines, which were exacerbated by a head injury in the 1860s. She was depressed for much of her life; some ... Grand Rapids, Michigan: Wm.B. Eerdmans Publishing Company. p. 434. ISBN 9780802838728. "The Death of President Lincoln, 1865". ... Responsible for hosting many social functions, she has often been blamed by historians for spending too much money on the White ... Assassination of President Lincoln.DETAILS OF THE FEARFUL CRIME.Closing Moments and Death of the President.Probable Recovery of ...
Nine days after his arrest, Anwar appeared in court with serious head and neck injuries. As the Royal Commission of Inquiry ... This early period pitted a group of "young Turks" including Mahathir in wanting to cause rapid social change against an "old ... The economy eventually began its recovery under measures instituted by Mahathir, but Anwar continued his opposition to ... were conspicuously absent in 2004 due to the lack of functioning space and state domination over society. However, Anwar ...
... the injury has better prognosis for recovery of function: the peripheral nervous system has a greater capacity for healing than ... But it was not until Aulus Cornelius Celsus, born 30 BC, noted that a cervical injury resulted in rapid death that the spinal ... Most motor recovery occurs in the first year post-injury, but modest improvements can continue for years; sensory recovery is ... An "incomplete" spinal cord injury involves preservation of motor or sensory function below the level of injury in the spinal ...
One function of the initial segment is to separate the main part of an axon from the rest of the neuron; another function is to ... Concussion is considered a mild form of diffuse axonal injury. Axonal injury can also cause central chromatolysis. The ... The first step is rapid opening of calcium ion channels in the membrane of the axon, allowing calcium ions to flow inward ... it is possible to induce long-distance axonal regeneration which leads to enhancement of functional recovery in rats and mouse ...
Injuries or degenerative conditions (such as Alzheimer's or Parkinson's disease) can cause more rapid declines in health. ... A common symptom experienced as we age is a loss in fine motor function control. This means that using mice and trackpads can ... Video game rehabilitation integrates rehabilitation practices into popular gaming platforms for stroke recovery, neurological ...
They soon a function of large hospitals[clarification needed], where they provided a steady stream of low-paid idealistic ... Grand Rapids, Michigan: Zondervan. p. 42. ISBN 978-0-310-20029-1. R.D. Biggs (2005). "Medicine, Surgery, and Public Health in ... Harrison finds that the chances of recovery for a badly wounded British infantryman were as much as 25 times better than in the ... including injuries and illnesses relating to aging and mental illness. The Ayurvedic classics mention eight branches of ...
... Lindsey ... M. Massa, R. Campanelli, E. Bonetti, M. Ferrario, B. Marinoni, and V. Rosti, "Rapid and large increase of the frequency of ... R. K. Kharbanda, M. Peters, B. Walton et al., "Ischemic preconditioning prevents endothelial injury and systemic neutrophil ... "Impact of radial artery cannulation for coronary angiography and angioplasty on radial artery function," The American Journal ...
... Lindsey ... Recovery of endothelial function after IR and mechanical injury is rapid and not associated with a change in circulating EPC. ... function after mechanical injury in healthy subjects and the first demonstration in vivo in humans of rapid recovery. We have ... In conclusion, this is the first study to examine the time course of recovery of endothelial function following local injury to ...
Arterial injury and endothelial repair: rapid recovery of function after mechanical injury in healthy volunteers. ... Brachial artery low-flow-mediated constriction is increased early after coronary intervention and reduces during recovery after ... Endothelial, sympathetic, and cardiac function in inherited (6R)-L-erythro-5,6,7,8-tetrahydro-L-biopterin deficiency. ... Darbepoetin enhances endothelium-dependent vasomotor function in patients with stable coronary artery disease only after ...
Though the rodent literature provides a causal understanding of post-injury recovery mechanisms, it has had a limited impact on ... Though the rodent literature provides a causal understanding of post-injury recovery mechanisms, it has had a limited impact on ... are promising tools that could enhance functional recovery of reach-to-grasp post-brain injury. ... are promising tools that could enhance functional recovery of reach-to-grasp post-brain injury. ...
Multi-Color Autofluorescence and Scattering Spectroscopy Provides Rapid Assessment of Kidney Function Following Ischemic Injury ... We aim to evaluate the use of noncontact optical signatures for rapid assessment of tissue function and viability. Specifically ... We aim to evaluate the use of noncontact optical signatures for rapid assessment of tissue function and viability. Specifically ... Functional changes in rat kidneys during the induced ischemic injury and recovery phases were explored using multimodal ...
Functional Recovery in Children and Adolescents With Spinal Cord Injury. Choksi, Ankita; Townsend, Elise L.; Dumas, Helene M.; ... Effect of Thoracic Lumbar Sacral Orthoses on Function for Adolescents With Incomplete Spinal Cord Injuries. Hanson, Heather L. ... perceived rapid attainment of goals; and stress and fatigue during an intense physical therapy program. ... Functional Recovery in Children and Adolescents With Spinal Cord Injury. Brown, Ryan; Tucker, Carole A. ...
Enhanced immune function. *Improved circulation. *Less pain. *More rapid recovery from traumatic injury ... So it was in an attempt to shorten the recovery time from common injuries that the German National Hockey Team began ... sports injuries, and other injuries of the knees and ankles. Included among these are 11 double-blind, placebo-controlled ... Each of 100 injuries the athletes suffered was well-documented, and the healing process carefully and systematically monitored ...
The 2019 Gordon Research Conference on Central Nervous System Injury and Repair will be held in Waterville Valley, NH. Apply ... Oxygen Transport Mediates Rapid Recovery of Diaphragm Function Following Chronic Spinal Injury ... Secondary injury further exacerbates injury. These barriers collectively present a great challenge in restoring the original ... Spinal cord injury is a major medical challenge. Despite many years of effort, effective therapies are still lacking due to the ...
Neuropraxia: no wallerian degeneration and complete and rapid recovery of function. Axonotmesis: wallerian degeneration and ... Neurotmesis: this type of injury involves the endoneurium with wallerian degeneration. Recovery is difficult. There are several ... facial nerve injury, injury to the other cranial nerve, disordered vestibular compensation. Gopen Q (15 December 2013). ... Uncontrolled bleeding or injury to I.A.C. is most serious complication during surgery. For patient with total hearing loss, ...
That puts his recovery on the rapid side of the typical range of three to six months. Im a very impatient person, he ... A common injury among boomers, a full tear may require surgery. Typically, the repair is made with an arthroscopic procedure. ... The likelihood of such an injury increases proportionately with age. It can be exacerbated by shoulder overuse in sports - such ... To find out whats involved with the common, but torturous, procedure, we followed Fudges journey from injury through surgery ...
More complete & rapid recovery from aphasia is seen in closed head injuries or stroke? ... Possibly more diffuse organization of function & in females & earlier LH maturation, so there is evidence of greater likelihood ... How may the phenomenon of diaschisis help to account for functional recovery after a focal brain injury? ... As pts age, the mechanisms that promoted recovery earlier in life may be called on to compensate for neuronal deterioration ...
Experimental diffuse traumatic brain injury results in persisting histopathology in the thalamus, Behavioural Brain Research" ... TBI-induced persisting histopathology indicates prolonged reparative processes rather than rapid recovery. ... DeepDyve requires Javascript to function. Please enable Javascript on your browser to continue. ... Recovery from visual and acoustic hyperaesthesia after mild head injury in relation to patterns of behavioural dysfunction ...
2006) Effect of injury severity on lower urinary tract function after experimental spinal cord injury. Prog Brain Res 152:117- ... Rapid improvements in the first 3 weeks after experimental incomplete spinal cord injury have been observed in response to ... PD168393 promotes functional recovery from spinal cord injury. Already 4 d after spinal cord injury, we detected differences in ... functionally valuable recovery of hindlimb function and bladder emptying, accompanied by improved sensory function, eating, and ...
If the return of function is rapid, this usually is a good sign. Typically, most recovery of muscle strength occurs in the ... What Determines the Severity and Outcomes of Brachial Plexus Injury?. How severe a brachial plexus injury is depends on two ... Bracial Plexus Injuries. Brachial Plexus: What Is It?. The brachial plexus is made up of five nerves, which are fibers that ... the amount of injury to the nerve. Although five nerves make up the brachial plexus, in many instances, the first two are the ...
Read chapter 9 SOCIAL FUNCTIONING: The seventh in a series of congressionally mandated reports on Gulf War veterans health, ... associated with rapid GCS 4-5. Five subjects recovery 80% of cases had who had PTA , injury caused by 10 weeks were road ... after injury: OR, 1.14 (0.32â cases injury cases for injury other 90% with mild 4.09) than brain injury TBI based on Brain- ... At 6 months after injury, social functioning was assessed with the SF-36 Physical Functioning and Social Functioning scales, ...
... and survivors many not regain the same pre-injury function. Subdural and epidural hematomas are serious injuries and recovery ... The most crutial aspect for recovery in patients with severe hematomas is rapid diagnosis and appropriate treatment. Once the ... Outcomes vary from minor injuries that require short recovery times to severe injuries that can lead to death. Short-term ... In hockey, traumatic brain injuries constitute 10%-15% of all head injuries. With the high percent of injuries being traumatic ...
Cell injury went from reversible, with rapid recovery of cellular functions and growth, to profound and irreversible. At ... Bradford M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of ... Photodynamic therapy sensitivity is not altered in human tumor cells after abrogation of p53 function. Cancer Res 1999;59:331-5 ... Semisynthetic homoharringtonine induces apoptosis via inhibition of protein synthesis and triggers rapid myeloid cell leukemia- ...
This page contains the abstract The Rapid and Progressive Degeneration of the Cervical Multifidus in Whiplash: An MRI Study of ... Fatty Infiltration http://www.chiro.org/Whiplash/The_Rapid_and_Progressive_Degeneration.shtml ... and full recovery following whiplash injury. Pain. 2013;154(10):2198 2206 *. Foa EB, Cashman L, Jaycox L, Perry K. The ... indicates that higher levels of TNF-α may influence the recovery of muscle function. On the contrary, others have demonstrated ...
Recovery from full-thickness burn injuries requires costly and complex critical care. Despite the administration of ... Effective skin substitute treatments that provide rapid and permanent wound closure lead to restoration of immune function, one ... of the key factors to burn patients survival and recovery.. "This partnership with the USAISR and Amarantus allows us to ... cell matrix from ESS has the potential to provide a more effective direct permanent restoration of structure and function of ...
When its a significant injury, not just a hot pizza, that damages your tongue and taste buds, you appear to need a cell type ... An early sign of reduced vigor may be reduction in the usually rapid response of neutrophils and macrophages to the injury site ... They know IL-1 affects the function of taste bud cells because when they squirt some on the functioning cells in a dish, it ... another indicator of the importance of the cytokine in recovery from a significant injury. Fragile nerves can be injured by not ...
Age at injury for the sample ranged from 2 to 7 years. Research from the developmental neurosciences describes rapid brain ... Predictors of Cognitive Function and Recovery 10 Years After Traumatic Brain Injury in Young Children. Vicki Anderson, Celia ... Predictors of Cognitive Function and Recovery 10 Years After Traumatic Brain Injury in Young Children ... Predictors of Cognitive Function and Recovery 10 Years After Traumatic Brain Injury in Young Children ...
Age dramatically delays the time if takes to recover the sense of taste following a significant nerve injury, Medical College ... In adult rats, they documented the usual, rapid neutrophil response at the immediate site of a taste system injury and in ... If you mess with it, you are going to change nerve function," McCluskey said. "Ultimately we have to look upstream at some of ... In younger rats, injury to the chorda tympani nerve, which innervates the front of the tongue, typically prompts an infusion of ...
Therefore, early detection of adverse effects of drugs as well as the clinical history of the patient, basic renal functions, ... and renal scarring leading to acute or chronic kidney injury. ... characterized by relatively rapid recovery of renal function. ... Acute kidney injury is the deterioration of the renal function over hours or days, resulting in the accumulation of toxic ... 3.4 Kidney injury molecule-1 (KIM-1). KIM-1 is a transmembrane glycoprotein. After ischemic or toxic injury, its levels elevate ...
Application of PEG produced a very rapid recovery of CTM function in 73 % of treated animals within the first 24 h compared ... Borgens, R. B. and Bohnert, D. (2001). Rapid recovery from spinal cord injury following subcutaneously administered ... One day post-injury to 1 month post-injury recordings show the recovery of SSEP conduction. The dotted line marks the ... The spinal injury. The means of injury we chose was a constant-displacement injury in which each spinal cord received a severe ...
Health care industry Brain Care and treatment Diagnosis Injuries Brain injuries Chronic brain injury Chronic traumatic ... The next generation in brain recovery and neuroregeneration. by Journal of American Physicians and Surgeons; ... and rapid recovery from major depression. (17) Zinc is needed for healthy brain function, and has been shown to possess ... Magnesium therapy and recovery of function in experimental models of brain injury and neurodegenerative disease. Clin Calcium ...
Together we can address recovery from injury, illness and surgery; coping with a life-long disability; and acute and chronic ... Neurologic disorders, such as Parkinsons disease, strokes, spinal cord injuries or multiple sclerosis, affect daily function ... Wisconsin Rapids Center. https://www.marshfieldclinic.org/Locations/Centers/Wisconsin Rapids Center. Wisconsin Rapids Center. ... We can help you prevent injury, assess a sports technique or recover from an injury. ...
Together we can address recovery from injury, illness and surgery; coping with a life-long disability; and acute and chronic ... Neurologic disorders, such as Parkinsons disease, strokes, spinal cord injuries or multiple sclerosis, affect daily function ... We can help you prevent injury, assess a sports technique or recover from an injury. ... If an injury or illness has prevented you from working, getting back on the job is a top concern. ...
Rapid,Recovery,from,Alzheimers,,Stroke,and,Brain,Injury,is,Now,Being,Taught,in,a,Newly,Released,Video,medicine,medical news ... so too perispinal Enbrel can induce the recovery of functions lost for a variety of reasons due to excess inflammation in the ... Therapeutic evaluation of etanercept in a model of traumatic brain injury.. ncbi.nlm.nih.gov/pubmed/21254790 Rapid improvement ... Neurological Wellness Centers Novel Neuro-Inflammation Inhibition Procedure that Induces Rapid Recovery from Alzheimers, ...
To ensure the continuity of the skin structure and the integrity of its function, a dynamic and highly controlled recovery ... The tissue remodeling period can start 2 weeks after injury, and the duration may be up to 1 year. The cells activated in the ... To solve the problem of its rapid inactivation in the body, Ren et al. used nano-mesoporous silicon as an intermediate carrier ... 1977). Influence of the burn wound on local and systemic responses to injury. Ann. Surg. 186, 444-458. doi: 10.1097/00000658- ...
These cellular events directly correlate with recovery from heart failure and restoration of normal LV function in less than 2 ... we evaluated the functional contribution of CSC activation to myocyte regeneration and LV recovery following myocardial injury ... We have previously shown that following diffuse myocardial damage, the myocardium responds with rapid CSC activation, ... LV function was measured by echocardiography. The increase in CSC number normally found after ISO was completely abolished by 5 ...
  • Non-invasive brain stimulation (NIBS) methods, such as transcranial magnetic stimulation and transcranial direct current stimulation, are promising tools that could enhance functional recovery of reach-to-grasp post-brain injury. (frontiersin.org)
  • We propose that a cross-species comparison of reach-to-grasp recovery could provide a mechanistic framework for clinically efficacious NIBS treatments that could elicit better functional outcomes for patients. (frontiersin.org)
  • When used as an intervention in clinical populations, NIBS techniques such as transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS) have been shown to modulate localized regions of activity in the cortex and are administered either independently or in combination with task-specific training to promote functional recovery. (frontiersin.org)
  • Functional changes in rat kidneys during the induced ischemic injury and recovery phases were explored using multimodal autofluorescence and light scattering imaging. (osti.gov)
  • This analysis of both the light scattering and autofluorescence images suggests that changes in tissue microstructure, fluorophore emission, and blood absorption spectral characteristics, coupled with vascular response, contribute to the behavior of the observed signal, which may be used to obtain tissue functional information and offer the ability to predict posttransplant kidney function. (osti.gov)
  • article{osti_1361609, title = {Predictive assessment of kidney functional recovery following ischemic injury using optical spectroscopy}, author = {Raman, Rajesh N. and Pivetti, Christopher D. and Ramsamooj, Rajendra and Troppmann, Christoph and Demos, Stavros G.}, abstractNote = {Functional changes in rat kidneys during the induced ischemic injury and recovery phases were explored using multimodal autofluorescence and light scattering imaging. (osti.gov)
  • An emerging consensus is that better understanding of mechanism, together with combinatorial approaches to stimulate neural repair, will be necessary to induce functional recovery. (grc.org)
  • The goal is to collectively accelerate discovery and translation of treatments that will lead to functional recovery. (grc.org)
  • Here we show that rats subjected to weight-drop spinal cord injury can be effectively treated by direct delivery of a potent EGFR inhibitor to the injured area, leading to significantly better functional and structural outcome. (jneurosci.org)
  • Concussion may result in neuro-pathological changes, but the acute clinical symptoms largely reflect a functional disturbance rather than a structural injury. (wikipedia.org)
  • Consistent with previous evidence, muscle degeneration occurs soon after injury but only in those patients with poor functional recovery. (chiro.org)
  • 6 ] A number of psychosocial factors (e.g., coping, expectations, anxiety and depression) have been identified as being associated with poor functional recovery. (chiro.org)
  • 2 ] Despite the presence of and recognition for these factors, current best multimodal treatments have not substantially influenced the rate of functional recovery. (chiro.org)
  • While the quantification of MFI in whiplash [ 5, 13 15 ] is intriguing, the mechanisms underlying its development in and their contribution towards poor functional recovery is largely unknown. (chiro.org)
  • Unfortunately, following a significant injury in humans, even with microscopic surgery to help repair nerves, about half of patients don't get functional recovery. (news-medical.net)
  • They are inhibiting signaling of the IL-1 receptor during development, in adulthood and in select cell populations like leukocytes and taste bud cells in mice, to see if that delays or even prevents a functional recovery as they suspect it will. (news-medical.net)
  • Childhood traumatic brain injury (TBI) has implications for functional outcomes, but few studies have documented long-term outcomes. (aappublications.org)
  • The purpose of this study was to plot recovery of cognitive and functional skills after early childhood TBI to 10 years postinjury and to identify the contribution of injury, environment, preinjury characteristics, and acute functional recovery. (aappublications.org)
  • Furthermore, a brief (2 min) application of the fusogen ( M r 1800, 50 % w/v aqueous solution) to the exposed spinal cord injury in vivo can also cause rapid recovery of nerve impulse conduction through the lesion in association with functional recovery. (biologists.org)
  • Another approach, which is aimed at recovering functional deficits irrespective of the time since the original spinal injury, is to restore physiological conduction through intact but non-functional white matter by K + channel blockade. (biologists.org)
  • To establish a cause-effect relationship we evaluated the functional contribution of CSC activation to myocyte regeneration and LV recovery following myocardial injury. (ahajournals.org)
  • 92% and was associated with lack of LV functional recovery, as compared to the ISO/non 5-FU-treated animals. (ahajournals.org)
  • These findings demonstrate that type XVIII collagen is an important functional component of the liver matrix microenvironment and is crucial for hepatocyte survival during injury and stress. (sigmaaldrich.com)
  • However, whether blocking the entry of specific immune cell subsets will provide an adequate treatment of pain after injury will have to be reevaluated by taking into consideration other key responses such as axonal regeneration, nerve repair, and functional recovery. (jneurosci.org)
  • Finally, we investigated whether depletion of neutrophils, which we have found to infiltrate the nerve distal stump in an IL-1/TNF-dependent fashion, affects repair processes such as axonal regeneration and functional recovery. (jneurosci.org)
  • Proponents of MIS THA believe that this approach leads to a faster functional recovery, faster hospital discharge, and increased patient satisfaction. (biomedsearch.com)
  • The most common drug-induced renal structural-functional alterations include acute tubular necrosis (ATN), hemodynamically mediated kidney injury, acute allergic interstitial nephritis (AIN), intratubular obstruction, and glomerular disease. (psychiatryadvisor.com)
  • Rapid dilation of retinal vessels in response to flickering light (functional hyperemia) is a well-known autoregulatory response driven by increased neural activity in the inner retina. (bioportfolio.com)
  • Nerve transfers using an expendable nearby motor nerve to reinnervate a denervated nerve have resulted in more rapid and improved functional recovery than traditional nerve graft reconstructions following a peripheral nerve injury. (thejns.org)
  • In this study, the authors examined the use of a novel implantable wireless nerve stimulator capable of simultaneously delivering therapeutic electrical stimulation of injured peripheral nerve tissue and providing postoperative serial assessment of functional recovery. (thejns.org)
  • Electrical stimulation of injured nerves via implanted wireless stimulators significantly improved functional recovery. (thejns.org)
  • Brief electrical stimulation was observed to increase the rate of functional recovery after both nerve crush and nerve transection-and-repair injuries. (thejns.org)
  • Barclay Morrison III , associate professor of biomedical engineering at Columbia Engineering, has led the first study to determine underlying biological mechanisms that promote functional recovery of the blood-brain barrier (BBB) after blast injury. (columbia.edu)
  • NH001 is under clinical development to improve the functional outcome of patients in a vegetative state or minimally conscious state following a severe traumatic brain injury. (prleap.com)
  • Because dopaminergic function appears to be of importance in executive central nervous system function, such as arousal and memory, NH001 has been designed to help regain consciousness, accelerate recovery and improve the functional outcome of patients from a coma, vegetative or minimally conscious state following a traumatic brain injury. (prleap.com)
  • Mild traumatic brain injury (TBI) disrupts the brain's 'default mode' in a way that shows up on functional MRI and correlates with symptoms, researchers found. (medpagetoday.com)
  • The study findings "suggest that resting-state functional MR imaging can be used as an additional clinical tool for detecting subtle brain injury that is not apparent with conventional MR imaging," Ge's group wrote. (medpagetoday.com)
  • If longitudinal studies confirm these results, functional MRI monitoring of the default-mode network could track progression and recovery in mild TBI, they suggested. (medpagetoday.com)
  • To see what role it plays in mild TBI, Ge and colleagues compared 23 affected patients with posttraumatic symptoms within 2 months of injury and 18 age-matched healthy controls using resting-state functional MRI to map out energy expenditure across the brain while awake. (medpagetoday.com)
  • In a study published today, the team showed that a drug previously approved for other purposes can 'wake up' damaged peripheral nerves and speed repair and functional recovery after injury. (eurekalert.org)
  • Functional tests to quantify recovery following carpal tunnel release. (cdc.gov)
  • Some of the evidence for the preservation of function in the brains of patients in MCS comes from functional imaging, which allows mapping of brain activity by magnetic resonance imaging (MRI) scanning. (dana.org)
  • Several groups of investigators have used functional MRI (fMRI) to evaluate residual function in the brains of MCS patients. (dana.org)
  • The project will give successful candidate a very wide range of training on both in vitro and in vivo research techniques such as nerve crush injury, functional recovery analysis, whole nerve staining, fluorescent and confocal microscopy, genotyping, mRNA purification, cDNA synthesis, real-time PCR, western blot, immunohistochemistry and primary cell culture. (plymouth.ac.uk)
  • Despite growing evidence of the benefits of NIBS in reducing motor impairment after brain injury, there are still large gaps in our understanding of the optimal treatment parameters, the underlying neural mechanisms, and factors that influence outcomes. (frontiersin.org)
  • In addition to their comparable dexterity and homology to human cortical representation, rodent models offer several translational advantages-such as the availability of transgenic lines, feasibility of invasive function modulation, and imaging tools that can be exploited to study circuit function and behavioral outcomes under highly controlled environments ( 11 , 12 ). (frontiersin.org)
  • What Determines the Severity and Outcomes of Brachial Plexus Injury? (chp.edu)
  • Previous research has demonstrated that young children with traumatic brain injury are at elevated risk of poor outcomes, particularly following severe injuries. (aappublications.org)
  • The recoveries, verdicts, favorable outcomes, and testimonials described on this site are not an indication of future results. (hwnn.com)
  • Pathogenesis of post-ischemic cellular injury is discussed along with potential interventions (pharmacologic and non-pharmacologic) currently being used to improve clinical outcomes. (omicsonline.org)
  • If their results can be translated into humans, it could mean earlier and more rapid diagnosis of traumatic peripheral nerve injuries, enabling earlier surgery and better outcomes for patients whose nerves have been completely severed. (eurekalert.org)
  • Whilst much is known regarding the influence of chronic risk factors on the endothelium, relatively little is known about the response of the endothelium in vivo in humans to an acute injury, whether this is due to ischaemic or mechanical injury. (hindawi.com)
  • The mammalian intestinal mucosa exhibits a spectrum of responses after acute injury and repairs itself rapidly to restore the epithelial integrity. (asm.org)
  • Ischemic preconditioning prevents endothelial injury and systemic neutrophil activation during ischemia-reperfusion in humans in vivo," Circulation , vol. 103, no. 12, pp. 1624-1630, 2001. (hindawi.com)
  • Murine renal artery-derived EPCs (CD34+/CD105-) showed down-regulation of mmu-Mir218-5p/U6 RNA ratio after ischemic injury, while in human renal arteries, MIR218-5p expression was up-regulated after ischemic injury. (stanford.edu)
  • however, how the components of EE contribute to the recovery after retinal ischemic damage rema. (bioportfolio.com)
  • The notion of lethal reperfusion injury in the heart implies that injury ensues to viable myocytes at the time of reperfusion, over and above, the cellular damage normally attributed to the initial ischemic event. (omicsonline.org)
  • articles concerning reperfusion injury (lethal and otherwise), ischemia-reperfusion injury, apoptosis, microvascular injury, ischemic conditioning and different combinations thereof were consulted. (omicsonline.org)
  • These data show the potential utility of EV to limit severe renal ischemic injury after the occurrence. (asnjournals.org)
  • 2 , 14 , 15 In this report, we describe the use of renal cell extracellular vesicles (EV) to treat ischemic renal injury in rats. (asnjournals.org)
  • Ischemic preconditioning (IPC) is a highly conserved adaptation in which transient, sublethal ischemia protects from subsequent ischemic injury. (asnjournals.org)
  • Successful kidney transplantation, however, results in near normalization of the antioxidant status and lipid metabolism by eliminating free radicals despite the surge of oxidative stress caused by the surgical procedure and ischemic injury to the organ during the operation. (readbyqxmd.com)
  • Drugs can cause mild to moderate nephrotoxic problems such as intrarenal obstruction, interstitial nephritis, nephrotic syndrome, acid-base and fluid-electrolyte disturbances, alteration in intraglomerular hemodynamics, inflammatory changes in renal tubular cells, tubulointerstitial disease, and renal scarring leading to acute or chronic kidney injury. (intechopen.com)
  • It is both instructive and convenient to consider the catastrophic loss of behavioral function following spinal cord injury (SCI) as two different syndromes: the initial, or acute, phase and the subsequent chronic condition. (biologists.org)
  • This latter dynamic is often referred to as 'secondary injury' ( Honmou and Young, 1995 ), and it is the loss of white matter, which cannot be replaced, that frames the more permanent behavioral loss accompanying the long-term, or chronic, phase of the injury. (biologists.org)
  • Millions of Americans are affected by both acute and chronic traumatic brain injury (TBI), but there is no standard-of-care recovery therapy. (thefreelibrary.com)
  • Dry needling therapy reduces acute or chronic pain and improves muscle function. (marshfieldclinic.org)
  • Familiarity with the anatomical structure and function of the skin, as well as the difference between acute wound healing and chronic wound healing, is essential for the treatment of chronic wounds. (frontiersin.org)
  • People who survive a spinal cord injury will most likely have medical complications such as chronic pain and bladder and bowel dysfunction, along with an increased susceptibility to respiratory and heart problems. (rxlist.com)
  • Successful recovery depends upon how well these chronic conditions are handled day to day. (rxlist.com)
  • Soft tissue injuries may be sudden (acute) or get worse gradually (chronic). (vic.gov.au)
  • An injury that gets worse over time (for example, over three months) is often referred to as a chronic soft tissue injury. (vic.gov.au)
  • In particular, there is limited knowledge of the role development plays in establishing and maintaining chronic neuropathic pain after injury to the peripheral nervous system. (asahq.org)
  • These results with a subacute model of pain and hypersensitivity suggest that responses to nerve injury leading to chronic pain may also vary with age. (asahq.org)
  • The objectives of this study are to characterize the behavioral responses using mechanical thresholds in animals of different ages using two different models of chronic neuropathic pain and to evaluate developmental differences in responses to these injuries. (asahq.org)
  • Methods to restore respiratory function following chronic cervical spinal cord injury (SCI) have not been extensively studied. (physoc.org)
  • Collectively, these data demonstrate the significant restoration of diaphragm function and nerve activity at chronic points following cervical SCI due to matrix modification, induction of plasticity and facilitation of drive. (physoc.org)
  • Also, Repetitive stress injuries or chronic strain involving the neck (such as using your neck to hold the phone) are a common, non-acute causes. (drestner.com)
  • PRLEAP.COM) NeuroHealing Pharmaceuticals, a company developing products for individuals with chronic brain injuries, today announced that the Food and Drug Administration (FDA) has awarded the company a three-year grant of $1,044,000 to assist in the clinical development of NH001. (prleap.com)
  • The level of oxidative stress markers is known to increase as chronic kidney disease progresses and correlates significantly with the level of renal function. (readbyqxmd.com)
  • The study appearing in EMBO Molecular Medicine , demonstrates for the first time that 4-aminopyridine (4AP), a drug currently used to treat patients with the chronic nerve disease, multiple sclerosis, has the unexpected property of promoting recovery from acute nerve damage. (eurekalert.org)
  • Although this drug has been studied for over 30 years for its ability to treat chronic diseases, this is the first demonstration of 4AP's benefit in treating acute nerve injury and the first time those benefits were shown to persist after treatment was stopped. (eurekalert.org)
  • As 4AP has been well-studied in chronic injuries, and is approved for treating multiple sclerosis, the new benefits we discovered can be explored rapidly and much more cheaply than is needed for developing an entirely new drug. (eurekalert.org)
  • Apnea, a common breathing-related sleep disorder, is frequently observed during the chronic brain injury period. (neuroskills.com)
  • IR and mechanical injury produced immediate impairment of FMD (from 6.5 ± 1.2% to 2.9 ± 2.2% and from 7.4 ± 2.3% to 1.5 ± 1.6% for IR and injury, resp. (hindawi.com)
  • Concussion typically results in the rapid onset of short-lived impairment of neurologic function that resolves spontaneously. (wikipedia.org)
  • Depending on the severity of the trauma (or repeated traumas), symptoms such as long-lasting cognitive impairment, depression, anxiety, sleep disturbances, and progressive neurodegeneration and decline may occur years after the injury. (thefreelibrary.com)
  • Although axonal impairment has long been known to be devastating for brain function in disease, until recently it was thought that axons showed minimal plasticity in healthy brains. (sfn.org)
  • 12 showed that parecoxib attenuates renal function impairment during porcine suprarenal aortic cross-clamping. (scielo.br)
  • Researchers at the University of Montreal expected that pre-teens (ages 9 to 12) would suffer the greatest impairment of cognitive function - the functions of the brain that involve thinking, concentrating, learning, and reasoning - compared with teens (ages 13 to 16) and adults, and that adolescents would, in turn, have more severe deficits than adults. (momsteam.com)
  • The mechanisms through which the central and autonomic nervous systems regulate the heart and the manner in which their impairment adversely affects cardiovascular function have recently been reviewed by Samuels. (ahajournals.org)
  • In addition, because it tests for verbal memory, the SAC cannot identify athletes who may suffer measurable impairment of neurocognitive function (primarily visual working memory) on neurocognitive tests, as well as altered activation in neurophysiologic function on sophisticated brain imaging tests (fMRI), resulting from repeated sub-concussive blows to the head . (momsteam.com)
  • Results indicate that severe injury is associated with poorest outcome, but after 3 years, the gap between children with severe traumatic brain injury and peers stabilizes. (aappublications.org)
  • METHODS: We performed high-angular-resolution diffusion imaging in 16 patients with acute severe traumatic brain injury who were comatose on admission and in 16 matched controls. (harvard.edu)
  • Increased medial prefrontal cortex activation has been reported previously in moderate and severe traumatic brain injury and is hypothesized to represent brain neuroplasticity operating in recovery and neural repair after injury," they wrote. (medpagetoday.com)
  • However, if the cerebral cortex itself has been damaged, for example by severe traumatic brain injury or a period of not getting enough oxygen, then the patient will go through "empty" wake-sleep cycles, where the eye opening is not accompanied by signs of cognition (responding to events in the environment). (dana.org)
  • We sought to define the time course of endothelial function recovery using flow-mediated dilation (FMD), after ischaemia-reperfusion (IR) and mechanical injury in patients and healthy volunteers. (hindawi.com)
  • A more severe mechanical injury was induced using an arterial sheath and catheter inserted into the radial artery of 18 patients undergoing angiography. (hindawi.com)
  • IR and minor mechanical injury were studied in healthy volunteers and the effects of a potentially more severe mechanical injury were examined in patients undergoing invasive testing for coronary artery disease. (hindawi.com)
  • Despite the administration of comprehensive care by specialized burn teams, the immunosuppression caused by the injury makes extensively burned patients susceptible to sepsis leading to increased morbidity and mortality. (cnbc.com)
  • Effective skin substitute treatments that provide rapid and permanent wound closure lead to restoration of immune function, one of the key factors to burn patients' survival and recovery. (cnbc.com)
  • Thirty-seven patients with head injury that was not complicated by significant hemorrhage or superficial laceration of the brain had coma or severe dementia, spastic quadriparesis, incontinence and autonomic dysfunction. (nih.gov)
  • Spinal cord injury patients who are intubated have to be carefully monitored for VAP and treated with antibiotics if symptoms appear. (rxlist.com)
  • Surgeons are being trained in the techniques, healthcare facilities are advertising their offerings, and patients are welcoming the potential for more cosmetically-appealing incisions and possibly quicker recoveries. (biomedsearch.com)
  • The diagnosis of aminoglycoside-induced nephrotoxicity is often difficult, particularly in critically ill patients with multiple comorbidities, and is confounded by other factors that are associated with the development of acute kidney injury, including concurrent dehydration, sepsis, hypotension, ischemia, and use of other nephrotoxic drugs. (psychiatryadvisor.com)
  • Both patients had recovery of left ventricular function within 30 days. (dovepress.com)
  • Herein, we briefly consider the evidence regarding the conundrum of reperfusion injury along with interventions that potentially limit its lethal consequences in patients. (omicsonline.org)
  • Rehabilitation after brain injuries like strokes requires that patients re-learn tasks such as moving a hand. (yale.edu)
  • Acute kidney injury (AKI) involves the rapid loss of kidney function consequent to a number of causes, which represents one of the main causes of morbidity and mortality in hospitalized patients. (spandidos-publications.com)
  • For patients with head injuries (non-blast related) and brain edema, doctors have been prescribing glucocorticoids, a class of steroid hormones, as standard treatment for the past 30 years. (columbia.edu)
  • The research goals of Dr. Wu's group are to improve the diagnosis, prognosis and management of patients with brain injury by quantifying and monitoring. (harvard.edu)
  • Diffuse axonal injury, a neural pathology occurring in post-TBI patients, is associated with a disruption of dopamine pathways. (prleap.com)
  • NeuroHealing previously presented findings of the response to NH001 treatment in eight patients with a traumatic brain injury who were in a vegetative or minimally conscious state for 1-4 months and neurologically stable for weeks prior to beginning of NH001 treatment. (prleap.com)
  • Patients' scores on the Trail Making Test B, which is "a measure of executive functioning to assess mental flexibility, specifically, the ability to shift rapidly between cognitive sets," significantly correlated with the decreased activity in the posterior regions of the default-mode network (multiple comparisons corrected P =0.02). (medpagetoday.com)
  • It is very gratifying to see patients return to normal function and activity after treating their orthopedic conditions. (stjhs.org)
  • For patients whose nerves are still connected, 4AP treatment could offer a new means to speed recovery, where none has previously existed. (eurekalert.org)
  • Some patients, however, show clear although minimal signs of cognitive recovery. (dana.org)
  • These patients are said to be in a "minimally conscious state" ( MCS ) and it is this group that has recently received attention as having the potential for more substantial recovery. (dana.org)
  • Interestingly, there is another smaller group of patients in whom this technology has been able to detect brain function, despite the appearance of complete unresponsiveness. (dana.org)
  • That number was even higher for severe brain injury patients. (flintrehab.com)
  • Renal replacement therapy (RRT) is a key component in the management of severe acute kidney injury (AKI) in critically ill patients. (biomedcentral.com)
  • Acute kidney injury (AKI) is a common yet highly devastating complication in critically ill patients [ 1 ]. (biomedcentral.com)
  • Sleep evaluations of CNS patients allow for the detection of sleep-related issues that are likely to hinder recovery. (neuroskills.com)
  • When old rats received nerve injuries similar to ones that can occur in ear or dental surgery, their taste buds took essentially twice as long to recover function as their younger counterparts, Dr. Lynnette McCluskey, neuroscientist in the MCG Schools of Graduate Studies and Medicine reported during the Association for Chemoreception Sciences annual meeting April 21-25. (scienceblog.com)
  • Due to the high impact needed for the scapular to fracture, a person with this type of injury typically has sustained other damage, such as nerve injuries, rib fractures, or lung injuries. (circlehealth.co.uk)
  • 8 By studying the behavioral effects of age in both models, the features common to both, as well as differences between them, will allow better understanding of the role of age in response to these two types of nerve injuries. (asahq.org)
  • Researchers at the University of Rochester Medical Center believe they have identified a new means of enhancing the body's ability to repair its own cells, which they hope will lead to better diagnosis and treatment of traumatic nerve injuries, like those sustained in car accidents, sports injuries, or in combat. (eurekalert.org)
  • Beyond nerve injuries sustained during accidents or in the line of duty, the researchers are also looking into using 4AP to repair nerve conduction after routine surgeries. (eurekalert.org)
  • Spinal cord injury is a major medical challenge. (grc.org)
  • In addition to the damage of axons, spinal cord injury leads to profound changes of the cellular and molecular environment, involving neurons, glia, immunity and other systems. (grc.org)
  • After spinal cord injury, proliferating astrocytes not only represent a physical barrier to regenerating axons but also express and secrete molecules that inhibit nerve growth, including chondroitin sulfate proteoglycans (CSPGs). (jneurosci.org)
  • The robust effects and the fact that other EGFR inhibitors are in clinical use in cancer treatments make these drugs particularly attractive candidates for clinical trials in spinal cord injury. (jneurosci.org)
  • Spinal cord injury (SCI) typically results in neurological dysfunction that cannot be reversed. (jneurosci.org)
  • Here we demonstrate robust beneficial effects of local infusion of an irreversible EGFR inhibitor onto the damaged area of the spinal cord on recovery from contusion spinal cord injury in rats. (jneurosci.org)
  • The observed effects and the fact that other EGFR inhibitors are in clinical use for the treatment of certain lung cancers may help pave the way for clinical trials of EGFR inhibition in spinal cord injury. (jneurosci.org)
  • Topical application of the hydrophilic polymer polyethylene glycol (PEG) to isolated adult guinea pig spinal cord injuries has been shown to lead to the recovery of both the anatomical integrity of the tissue and the conduction of nerve impulses through the lesion. (biologists.org)
  • Behavioral recovery was demonstrated using a long-tract, spinal-cord-dependent behavior in rodents known as the cutaneus trunci muscle (CTM) reflex. (biologists.org)
  • A severe compression/contusion injury to the exposed thoracic spinal cord of the guinea pig was performed between thoracic vertebrae 10 and 11. (biologists.org)
  • These results suggest that repair of nerve membranes by polymeric sealing can provide a novel means for the rapid restoration of function following spinal cord injury. (biologists.org)
  • How Does a Spinal Cord Injury Affect the Rest of the Body? (rxlist.com)
  • Any injury to the spinal cord at or above the C3, C4, and C5 segments, which supply the phrenic nerves leading to the diaphragm, can stop breathing. (rxlist.com)
  • Respiratory complications, primarily as a result of pneumonia , are a leading cause of death in people with spinal cord injury. (rxlist.com)
  • More than a quarter of the deaths caused by spinal cord injury are the result of VAP. (rxlist.com)
  • Spinal cord injuries in the cervical region are often accompanied by blood pressure instability and heart arrhythmias. (rxlist.com)
  • People with spinal cord injuries are at triple the usual risk for blood clots. (rxlist.com)
  • Spinal cord injury (SCI) remains a significant public health problem. (thejns.org)
  • Damage to sympathetic autonomic fibres that run in the cervical portions of the spinal cord may lead to drooping of the eyelid ( ptosis ) and a smaller pupil on the same side as the injury (Horner syndrome). (britannica.com)
  • As with lesions of the spinal cord, localization of the level of the lesion is determined by noting which of the cranial nerve functions are affected. (britannica.com)
  • Indeed, our data demonstrate that robust and rapid recovery of respiratory motor function is possible up to 1.5 years following severe cervical spinal cord hemisection through a combination of enzymatic degradation of perineuronal net associated proteoglycans and rehabilitative conditioning. (physoc.org)
  • Indeed, our results indicate that essentially complete recovery of motor function in this model of spinal cord trauma may not be limited by time after injury. (physoc.org)
  • Falling is common among individuals with incomplete spinal cord injury (iSCI), with most falls occurring while walking. (clinicaltrials.gov)
  • A traumatic spinal cord injury is a lesion of neural elements of the spinal cord that can result in any degree of sensory and motor deficit, and autonomic or bowel dysfunction. (ottobock.co.uk)
  • Most injuries to the spinal cord don't completely sever it. (ottobock.co.uk)
  • However, as our focus for treatments for such problems as spinal cord injury are geared towards re-establishing contact between higher systems and peripheral motor networks, it behooves us to understand how the distal networks have been altered as a result of deprivation of descending inputs. (biologists.org)
  • The current definition of concussion-immediate loss of consciousness with rapid and complete recovery of cerebral function-should not exclude the fact that a small number of neurons may have been permanently disconnected or have perished. (nih.gov)
  • Adolescents were included because previous studies suggested that the age group was more vulnerable to concussion than adults to the effects of concussion on cognitive function (6) children were included because practically nothing is know about the effects of sport concussion on pre-adolescents. (momsteam.com)
  • The Sideline SAC app is designed for rapid concussion evaluation on the sidelines. (appadvice.com)
  • SAC is not meant to replace comprehensive neuropsychological testing or used as a stand-alone tool for diagnose concussions, measure recovery, or make decisions about an athlete's readiness to return to competition after concussion. (appadvice.com)
  • It is also important to remember that symptoms of concussion may not appear until several hours, or even days, after injury with delayed onset of symptoms particularly common among younger athletes. (appadvice.com)
  • If no medical personnel are on the sports sideline, any athlete showing potential signs of concussion, such as balance or motor incoordination (stumbles, slow/labored movements), disorientation or confusion, loss of memory, blank or vacant look or visible facial injury combined with any of these other symptoms, should be removed from play, barred from returning and referred for a formal evaluation by a qualified health care professional. (momsteam.com)
  • Because the SAC only takes approximately 5 to 7 minutes to administer and was designed for use by clinicians with no neurocognitive testing experience, it is considered a 'practical sideline assessment tool' (2) which can 'detect changes across multiple domains of cognitive functioning that are susceptible to the acute effects of concussion. (momsteam.com)
  • A concussion is a traumatic brain injury that affects your brain function. (mayoclinic.org)
  • Adult, child and adolescent athletes with a concussion also should not return to play on the same day as the injury. (mayoclinic.org)
  • These injuries affect brain function, usually for a brief period, resulting in signs and symptoms of concussion. (mayoclinic.org)
  • Recovery for what cognitive function is most extensive? (brainscape.com)
  • Some stages are particularly important for memory, emotional well-being, and cognitive function, and may be compromised by interrupted sleep. (neuroskills.com)
  • Methods of reducing inflammation and promoting neural recovery include hyperbaric oxygenation therapy (HBOT) and nutritional doses of magnesium, lithium, and zinc. (thefreelibrary.com)
  • At the same time the nervous system must be stable, so that the neural circuits that produce behavior function throughout the lifetime of the animal and that changes produced by learning endure. (biologists.org)
  • We are only beginning to understand how neural networks strike a balance between altering individual neurons in the name of plasticity, while maintaining long-term stability in neural system function. (biologists.org)
  • The balance of this plasticity and stability in neural networks undoubtedly plays a critical role in the normal functioning of the nervous system. (biologists.org)
  • While mechanisms of synaptic plasticity have garnered extensive study over the past three decades, it is only recently that more attention has been turned to plasticity of intrinsic excitability as a key player in neural network function. (biologists.org)
  • Alternatively, alterations in intrinsic excitability also can have a stabilizing influence on neural function. (biologists.org)
  • Neurological Wellness Center's Novel Neuro-Inflammation Inhibition Procedure that Induces Rapid Recovery from Alzheimer's, Stroke and Brain Injury is Now Being Taught in a Newly Rele. (bio-medicine.org)
  • This 24-minute video and 25-page e-book are now available online at http://www.neurological-recovery-guide.com . (bio-medicine.org)
  • Systemic treatment of mice with an anti-Ly6G antibody to deplete neutrophils, cells that play an essential role in the genesis of neuropathic pain, did not affect recovery of neurological function and peripheral axon regeneration. (jneurosci.org)
  • Conditions treated include painful musculoskeletal and neurological conditions, sports injuries, work related injuries, paediatric conditions and repetitive strain injuries. (whatclinic.com)
  • Together, these results suggest that targeting specific IL-1β/TNF-dependent responses, such as neutrophil infiltration, is a better therapeutic strategy for treatment of neuropathic pain after peripheral nerve injury than complete blockage of cytokine production. (jneurosci.org)
  • Since the inflammatory response that rapidly develops after peripheral nerve injury may contribute to both neuropathic pain and nerve regeneration, it is critical to determine the exact role(s) of immune cells and molecules in pathomechanisms after nerve injury. (jneurosci.org)
  • Wireless stimulators successfully facilitated therapeutic stimulation of peripheral nerve tissue and serial assessment of nerve recovery. (thejns.org)
  • 8-10 The PSL model, being a more peripheral injury and only part of the nerve, allows commingling of nerve fiber types of both injured and uninjured nerves, probably deprives the cell body of less traffic due to preservation of more axon, and may be more akin to peripheral nerve injury from trauma, surgery, or tumor. (asahq.org)
  • When this insulation is damaged, as occurs in traumatic peripheral nerve injury, nerve cell function is impaired. (eurekalert.org)
  • The current standard of care for traumatic peripheral nerve injury is "watchful waiting" to determine whether a nerve has the ability to spontaneously recover, or if it will require surgery. (eurekalert.org)
  • This PhD studentship will use gene knockout mouse models to study the functions of the axon guidance receptor EphA5 and the transcription factor Runx2 in peripheral nerve regeneration. (plymouth.ac.uk)
  • Motor and sensory functions are improved and bladder function is restored. (jneurosci.org)
  • Injury causes motor and sensory deficits, as well as bladder, bowel, and sexual dysfunction. (jneurosci.org)
  • She's principal investigator on a $1.6 million grant from the National Institute on Deafness & Other Communicative Disorders that is helping her lab better define how we rebuild our sense of taste and possibly discover a novel way to also aid recovery of other sensory functions that enable us to also smell, touch, hear and see the world. (news-medical.net)
  • The speakers will describe the discovery and function of molecules that serve as sensory receptors or sensory transducers, including their clinical relevance. (sfn.org)
  • Loss of function in ascending sensory pathways results in the loss of superficial pain, temperature, crude light touch, and scratch sensations if the spinothalamic tract is damaged, but it will cause loss of joint position, vibration, and discriminative light-touch sensations if the dorsal columns are the site of injury. (britannica.com)
  • A method to evaluate sensory and motor function related to carpal tunnel syndrome was investigated. (cdc.gov)
  • The outcome variables included dynamic sensory gap-detection thresholds and rapid pinch-and-release rates. (cdc.gov)
  • The first stages of cerebral injury after TBI are characterized by tissue damage, axonal shearing, contusions, and impaired regulation of cerebral blow flow (CBF) and metabolism. (thefreelibrary.com)
  • This symposium will highlight recent advances in mechanisms controlling axonal function, how these mechanisms are plastic, and how axonal plasticity impacts brain function. (sfn.org)
  • Also, disrupted connectivity in the default-mode network could have been caused by structural problems, such as axonal injury, which wasn't looked at in the study, they acknowledged. (medpagetoday.com)
  • Despite the lack of pathological findings, a recent prospective investigation using conventional T1-weighted magnetic resonance imaging (MRI) uniquely identified neck muscle fatty infiltrates ( MFI ) between one- and three-months post injury in participants with more severe levels of WAD-related disability and symptoms of post-traumatic stress (PTSD). (chiro.org)
  • Just as ibuprofen can alleviate the symptoms of sunburn, headache, a sprained ankle or back pain, so too perispinal Enbrel can induce the recovery of functions lost for a variety of reasons due to excess inflammation in the brain. (bio-medicine.org)
  • The patient ultimately recovered near normal motor function of the median nerve, but had persistent pain symptoms 4 years postinjury. (thejns.org)
  • For six subjects experiencing local trauma, REAC-TO was effective in speeding the healing time of contusion symptoms and providing recovery of function. (dovepress.com)
  • These issues can mimic the symptoms of other types of brain injury. (flintrehab.com)
  • Therefore, if your brain injury symptoms do not improve with traditional therapy, your problems might stem from your pituitary. (flintrehab.com)
  • That's why today's article will explain the symptoms, causes, and treatments of pituitary dysfunction after brain injury. (flintrehab.com)
  • Many of the symptoms of pituitary damage mimic normal traumatic brain injury symptoms. (flintrehab.com)
  • Common symptoms after a concussive traumatic brain injury are headache, loss of memory (amnesia) and confusion. (mayoclinic.org)
  • This type of brain injury may lead to bleeding in or around your brain, causing symptoms such as prolonged drowsiness and confusion. (mayoclinic.org)
  • That's why anyone who experiences a brain injury needs monitoring in the hours afterward and emergency care if symptoms worsen. (mayoclinic.org)
  • Therefore, early detection of adverse effects of drugs as well as the clinical history of the patient, basic renal functions, drug-related risk factors, and nephrotoxic drug combinations must be well known in order to prevent drug-induced nephrotoxicity and progression to end-stage renal disease. (intechopen.com)
  • Acute kidney injury is the deterioration of the renal function over hours or days, resulting in the accumulation of toxic wastes and the loss of internal homeostasis. (intechopen.com)
  • To evaluate the effect of parecoxib (an NSAID) on renal function by measuring plasma NGAL (serum neutrophil gelatinase-associated lipocalin) levels in an induced-ischemia rat model. (scielo.br)
  • However, the detection of COX-2 in the kidneys under normal conditions or under conditions of impaired renal blood flow (RBF) and glomerular filtration rate (GFR) has attracted the attention of researchers to the role of these drugs in maintaining renal function 4 - 6 . (scielo.br)
  • However, administration of parecoxib may affect renal function in an unknown way, especially in situations of diminished renal perfusion such as dehydration, hemorrhage, heart failure, low-salt diets, and stroke 3 , 8 , 9 . (scielo.br)
  • Renal function can be monitored using the neutrophil gelatinase-associated lipocalin (NGAL) biomarker, whose expression is induced by renal epithelial injury. (scielo.br)
  • In fact, NGAL is one of the earliest markers of renal injury after ischemia or nephrotoxic injury in animal models 10 . (scielo.br)
  • There is no consensus on the effect of parecoxib on renal function. (scielo.br)
  • 11 used the concentration of creatinine in ischemia/reperfusion models in rats and showed that parecoxib increases renal dysfunction and injury associated with this form of renal stress. (scielo.br)
  • This study aimed to evaluate the effects of parecoxib on renal function by measuring plasma NGAL levels in an induced-ischemia model in rats and histologically evaluate possible lesions. (scielo.br)
  • We now show that EV from adult rat renal tubular cells significantly improved renal function when administered intravenously 24 and 48 hours after renal ischemia in rats. (asnjournals.org)
  • We derived this work from prior experimentation that showed improved renal function and structure by relatively small numbers of infused renal cells. (asnjournals.org)
  • Podocyte injury has emerged as a significant contributor to many forms of renal disease and is characterized by remodeling of the actin cytoskeleton, loss of slit diaphragms, and foot process effacement, leading to proteinuria. (asnjournals.org)
  • Optimal timing of renal replacement therapy initiation in acute kidney injury: the elephant felt by the blindmen? (biomedcentral.com)
  • Non-invasive brain stimulation (NIBS) is of interest as both a prognostic tool for predicting motor recovery after brain injury and as a novel option for rehabilitation treatment ( 5 - 8 ). (frontiersin.org)
  • Recovery programs, such as Stepping Stones , offer rehabilitation and exercises designed to help you move forward physically and emotionally. (marshfieldclinic.org)
  • This raises the potential that manipulating Nogo Receptor in humans might accelerate and magnify rehabilitation after brain injuries like strokes," said Feras Akbik, Yale doctoral student who is first author of the study. (yale.edu)
  • A personal Interest in sports and the rapid rehabilitation after injury. (stjhs.org)
  • The MCG team has seen that IL-1, which is actually activated in the both neurons and taste bud cells by the injury, quickly recruits immune cells to the scene. (news-medical.net)
  • Similar studies have shown that age only slightly delays recovery time for neurons that enable movement. (scienceblog.com)
  • Speakers will address key questions about cytoskeletal regulation in development, signaling, disease and injury using multiple experimental approaches in vertebrate and invertebrate neurons. (sfn.org)
  • For example, injury to the cord at mid-thoracic levels spares the arms, which are innervated by fibres originating from higher segments, but it causes characteristic signs (abnormal posture, spastic tone, weakness, increased deep reflexes, and abnormal plantar reflexes) of damage to motor neurons originating below that level-as well as the loss of bladder and bowel control. (britannica.com)
  • The comparative rigidity of the adult brain results in part from the function of a single gene that slows the rapid change in synaptic connections between neurons. (yale.edu)
  • In other words, the intrinsic excitability of neurons is responsible for the translation of synaptic input to the particular output function of a given neuron. (biologists.org)
  • Finally, it is possible that changes occur in the intrinsic properties of neurons in networks with disrupted innervation as a result of injury or disease. (biologists.org)
  • Predictors of outcome included preinjury ability (for adaptive function) and family function (social/behavioral skills). (aappublications.org)
  • Environmental factors were found to contribute to adaptive and social/behavioral recovery. (aappublications.org)
  • Previous studies have demonstrated differences in behavioral responses to the more peripheral injury of partial sciatic nerve ligation (PSL) compared with the more proximal SNL model. (asahq.org)
  • 5 There are differences in sympathetic fiber growth after the different injuries, which may play a role in the differential behavioral responses. (asahq.org)
  • Her ultimate goal is to be able to manipulate IL-1 signaling in specific cell populations at specific times to speed regeneration and recovery. (news-medical.net)
  • They have genetically blocked it and are now also blocking it with drugs, and suspect they will find that for proper regeneration, IL-1 will be needed within hours of an injury in all the affected cells. (news-medical.net)
  • Abstract 224: Cardiac Stem Cell Ablation Blocks Regeneration, Exacerbates Cardiac Remodeling and Increases Mortality after Diffuse Myocardial Injury. (ahajournals.org)
  • COX-1 is also called a constitutive enzyme and is involved in cell function, regeneration and repair, whereas COX-2, which is called an inducible enzyme, depends on an inflammatory process or the malfunction of the aforementioned organs and systems 3 , 4 . (scielo.br)
  • The rapid response of the peripheral nervous system after trauma injury provides an excellent research model to study gene function that is important for regulating the process of nerve regeneration and tissue repair. (plymouth.ac.uk)
  • Damage to these systems following stroke or traumatic brain injury (TBI), commonly leads to long-term deficits in reach-to-grasp function ( 1 , 2 ). (frontiersin.org)
  • The purpose of this review is to compare and contrast current literature on reach-to-grasp deficits in pre-clinical rodent models and human studies, and to highlight how neurostimulation in pre-clinical rodent models of brain injury could provide a mechanistic basis for improving reach-to-grasp function in humans. (frontiersin.org)
  • Contrary to speculation about "growing into deficits," after protracted recovery to 30 months, young children make age-appropriate progress at least to 10 years postinsult. (aappublications.org)
  • Abusive head trauma (AHT) is a spectrum, ranging from mild injury from sub-lethal abuse that can cause lethargy, irritability, poor feeding, and/or vomiting occurring for days or weeks, to the most severe injury leading to coma and/or death. (netce.com)
  • With acute cruciate injury, there is often a history of trauma such as an automobile accident or a fall from a height. (vcahospitals.com)
  • Broken shoulder blade: An injury to the shoulder blade usually is associated with relatively forceful trauma. (drestner.com)
  • When it's a significant injury, not just a hot pizza, that damages your tongue and taste buds, you appear to need a cell type best known for its inflammation-promoting skills to help restore your sense of taste. (news-medical.net)
  • she says of critical junctures throughout our body where peripheral nerves connect with cells like those that comprise our functioning taste buds. (news-medical.net)
  • When the nerve is injured, the complex of cells that comprise the taste buds degenerates, taste buds disappear, and their injured nerve dies back to the injury site. (news-medical.net)
  • Interestingly taste buds and nerves were present much earlier but apparently not functioning. (scienceblog.com)
  • Bone marrow-derived mesenchymal stem cells (MSCs) have been found to improve recovery following AKI induced by toxic agents and ischemia/reperfusion injury ( 16 - 18 ). (spandidos-publications.com)
  • In addition to their usual treatments, the players took Wobenzym capsules either immediately after an injury or prophylactically before games. (nutritionreview.org)
  • The doctors can recommend surgery or other treatments to restore the person to some sense of functioning, however, people who suffer these injuries are not able to work again. (hwnn.com)
  • Effective treatments are performed by qualified and experienced physiotherapists for a wide range of painful conditions and injuries at this clinic located at Beaumont Park in Whitley Bay. (whatclinic.com)
  • In addition, REAC-TO treatments represented a rapid-acting analgesic associated with antiedematous, anti-inflammatory, and regenerative effects. (dovepress.com)
  • So, says Hue, "Speeding blood-brain barrier recovery is an important therapeutic target for developing new treatments for victims of bTBI. (columbia.edu)
  • IL-1β and TNF are potential targets in the management of neuropathic pain after injury. (jneurosci.org)
  • Reach-to-grasp is an evolutionarily conserved motor function that is adversely impacted following stroke and traumatic brain injury (TBI). (frontiersin.org)
  • The high degree of homology in reach-to-grasp circuitry between humans and rodents further implies that the application of NIBS to brain injury could be better informed by findings from pre-clinical rodent models and neurorehabilitation research. (frontiersin.org)
  • Given that reach-to-grasp movements are a fundamental skill for many daily activities, improving reach-to-grasp recovery after brain injury is a major goal of neurorehabilitation therapies ( 3 , 4 ). (frontiersin.org)
  • Rodent models have the potential to inform how neurostimulation can be useful in clinical applications, especially as it pertains to improving reach-to-grasp behavior after brain injury. (frontiersin.org)
  • Mild traumatic brain injury: is diffusion imaging ready for primetime in forensic medicine? (deepdyve.com)
  • A sports-related traumatic brain injury is a serious accident which may lead to significant morbidity or mortality. (wikipedia.org)
  • Concussions are also sometimes referred to as mTBI (Mild Traumatic Brain Injury). (wikipedia.org)
  • This study follows survivors of very early traumatic brain injury into adolescence. (aappublications.org)
  • Childhood traumatic brain injury (TBI) is a frequent cause of disrupted development and more common than other conditions affecting the central nervous system (eg, childhood cancer). (aappublications.org)
  • According to U.S. Centers for Disease Control and Prevention statistics, approximately 1.7 million people in the U.S. suffer a traumatic brain injury (TBI) each year. (thefreelibrary.com)
  • 1) Nearly 75% of TBIs that occur each year are concussions or other forms of mild traumatic brain injury (mTBI). (thefreelibrary.com)
  • Common to Alzheimer's, stroke and traumatic brain injury is excess inflammation in the brain. (bio-medicine.org)
  • The general counsel is to initiate perispinal Enbrel treatment as soon as possible after suffering a stroke or traumatic brain injury. (bio-medicine.org)
  • Some clients have experienced dramatic life-changing recoveries even when treatment was begun years after the stroke or traumatic brain injury. (bio-medicine.org)
  • One of the most complex types of injury you can suffer in an accident is a traumatic brain injury (TBI). (hwnn.com)
  • If you or a loved one has suffered a TBI, you should contact an experienced brain injury lawyer in Alabama . (hwnn.com)
  • What are the Long-Term Effects of a Traumatic Brain Injury? (hwnn.com)
  • Our research should stimulate renewed clinical interest in developing glucocorticoid therapies to treat blast-induced traumatic brain injury (bTBI) and other disorders of the central nervous system," Morrison says. (columbia.edu)
  • This improvement could be a significant result, as there are currently no approved pharmaceutical therapies for traumatic brain injury (TBI), and recently completed clinical trials have not demonstrated any benefit of other tested neuro-protective interventions. (columbia.edu)
  • PARTICIPANTS: Adults with traumatic brain injury (TBI). (harvard.edu)
  • Further, our studies characterize mechanisms responsible for pathologies associated with disruption of sleep/wake states: for example, post-traumatic stress disorder, neurodegeneration, failed recovery from traumatic brain injury, and drug addiction. (utsouthwestern.edu)
  • Pituitary dysfunction after traumatic brain injury can cause a wide range of problems. (flintrehab.com)
  • How Common Is Pituitary Dysfunction After Traumatic Brain Injury? (flintrehab.com)
  • Indeed, some studies estimate that around 56% of traumatic brain injury survivors will develop some type of pituitary dysfunction. (flintrehab.com)
  • In fact, they often resemble the normal side effects of brain injury, which makes them easy to miss. (flintrehab.com)
  • Sudden acceleration or deceleration of the head, caused by events such as a car crash or being violently shaken, also can cause brain injury. (mayoclinic.org)
  • Unfortunately, the prevalence of sleep disorders following brain injury is notably higher compared to the general population. (neuroskills.com)
  • Many of those that have endured a traumatic brain injury or stroke have difficulty initiating or maintaining sleep. (neuroskills.com)
  • CNS sleep facilities also provide research opportunities to deepen understanding of sleep-related issues after brain injury. (neuroskills.com)
  • The initial diagnosis of drug-induced nephrotoxicity typically involves detection of abrupt changes in kidney function manifesting as acute increases in serum creatinine, blood urea nitrogen (BUN), or decreased urine output, which is temporally related to initiation or ongoing use of a potentially nephrotoxic drug. (psychiatryadvisor.com)
  • It manifests as a gradual progressive rise in serum creatinine (typically an increase of 0.5 mg/dL or more) and BUN, and a corresponding decrease in kidney function. (psychiatryadvisor.com)
  • A decrease in kidney function evidenced by a rise in serum creatinine concentration may be seen within 72 to 96 hours after cisplatin exposure. (psychiatryadvisor.com)
  • We aim to evaluate the use of noncontact optical signatures for rapid assessment of tissue function and viability. (osti.gov)
  • In younger rats, injury to the chorda tympani nerve, which innervates the front of the tongue, typically prompts an infusion of immune cells called neutrophils to the injury site as well as surrounding tissue. (scienceblog.com)
  • Short-term, the neutrophils, which are like a front-line demolition crew pulverizing tissue for removal, can actually hinder the function of nearby nerves. (scienceblog.com)
  • In adult rats, they documented the usual, rapid neutrophil response at the immediate site of a taste system injury and in nearby tissue. (scienceblog.com)
  • The next stage, known as the subacute phase (more than 10 days, less than a year post-injury) is defined by tissue damage, and if healing is not progressing, Wallerian degeneration begins. (thefreelibrary.com)
  • A better knowledge of the functions of these cells and molecules could lead to the identification of new potential targets for treating neuropathic pain without interfering with the tissue repair program. (jneurosci.org)
  • The shoulder complex is made up of three main bones and a variety of soft tissue structures to help with the stability, movement and function of the shoulder. (circlehealth.co.uk)
  • In a lot of traumatic situations it is not just the fracture that needs to be treated but also any other soft tissue injuries. (circlehealth.co.uk)
  • Surgery may be indicated with proximal humeral fractures if the fracture was displaced or open, if there are other soft tissue structures involved or if there are injuries to the surrounding blood vessels of nerves. (circlehealth.co.uk)
  • A sudden injury is related to a specific incident and is often called an acute soft tissue injury. (vic.gov.au)
  • grade III - the soft tissue is totally torn, with considerable loss of function and strength. (vic.gov.au)
  • Most soft tissue injuries take a few weeks to heal, depending on the severity of the sprain or strain, any subsequent injuries or issues such as weakness, stiffness, poor balance or function, and the general health of the person. (vic.gov.au)
  • Mesenchymal stem cells (MSCs) contribute to the recovery of tissue injury, providing a paracrine support. (spandidos-publications.com)
  • Following injury, the clearance of apoptotic and necrotic cells is necessary for mitigation and resolution of inflammation and tissue repair. (jci.org)
  • These MSC secretory functions have been progressively enhanced by cell modification within gene therapy approaches, promoting tissue restoration in a more targeted manner. (biomedcentral.com)
  • We believe the autologous dermal and epidermal cell matrix from ESS has the potential to provide a more effective direct permanent restoration of structure and function of full thickness skin with minimal scarring. (cnbc.com)
  • These cellular events directly correlate with recovery from heart failure and restoration of normal LV function in less than 2 weeks. (ahajournals.org)
  • However, restoration of blood flow to reversibly injured cardiocytes (and other cardiac cell types) within the under-perfused region may also provoke additional damage-commonly referred to as lethal reperfusion injury. (omicsonline.org)
  • The occurrence of reperfusion injury may be inevitable but restoration of blood flow to the infarct-related artery is critical to ensure salvage of reversibly injured myocytes within the area at risk. (omicsonline.org)
  • Debate concerning prevalence of reperfusion injury continues but no true experimental model is presently available to distinguish damage caused by restoration of flow to the perfusion bed of the infarct related artery compared to that present at the end of ischemia. (omicsonline.org)
  • The authors present a single case of restoration of some hand function following a complete cervical SCI utilizing nerve transfers. (thejns.org)
  • We show that formation of the chondroitin sulphate proteoglycan (CSPG) rich perineuronal net is the major impediment to sprouting and reawakening of the residual cross-phrenic pathway that can lead to restoration of respiratory motor function regardless of time post injury. (physoc.org)
  • But older rats experience a much bigger invasion of neutrophils although McCluskey notes it doesn't seem to impact nearby nerve function as with younger rats. (scienceblog.com)
  • Most old rats eventually recovered their sense of taste but not until at least 85 days after injury. (scienceblog.com)
  • In his 1970 book Enzymtherapie, Dr. Wolf proposed that a disturbance of important physiologic regulatory and feedback mechanisms lay at the heart of most geriatric diseases-including the loss of immune function-and that the essential equilibrium within these systems depended on the actions of various proteolytic enzymes. (nutritionreview.org)
  • There is a growing incidence of drug-induced glomerular disease, including direct cellular injury and immune-mediated injury [ 5 ]. (intechopen.com)
  • Evidence now supports use of massage as an aid to muscle recovery after exercise or injury, a means to improved circulation, and a way to bolster immune function. (merckvetmanual.com)
  • Circulating EPC did not change significantly during the injury/recovery period in all subjects. (hindawi.com)
  • Those who used the product preventatively were able to return to their sport significantly faster after an injury than those who used conventional and potentially dangerous nonsteroidal anti-inflammatory drugs (NSAIDs) like aspirin or ibuprofen. (nutritionreview.org)
  • They also have proportionately fewer subsequent macrophages moving in which she suspects may be part of the reason for the significantly delayed recovery. (scienceblog.com)
  • Loss of median motor hand function and upper-extremity pronation can significantly impact a patient's ability to perform many activities of daily living independently. (thejns.org)
  • The objectives of this study were firstly to define the time course of endothelial repair (as measured by FMD) following ischaemia-reperfusion (IR) and mechanical injury. (hindawi.com)
  • Debate has gone on, and continues regarding the existence of reperfusion injury and the pathways that are solicited. (omicsonline.org)
  • This review examines evidence from basic science and clinical studies that support the premise of cardiac injury caused by reperfusion. (omicsonline.org)
  • Various forms of reperfusion injury can include myocardial and vascular stunning, microvascular injury and no-reflow, arrhythmias, etc. (omicsonline.org)
  • Rapid healing of injuries and sprain and relieves pain. (tradekorea.com)
  • A sprain is a type of joint injury that typically involves tearing of the ligaments and capsule. (vic.gov.au)
  • If a ligament is stretched or torn, the injury is called a sprain. (drestner.com)
  • They know IL-1 affects the function of taste bud cells because when they squirt some on the functioning cells in a dish, it increases their activity. (news-medical.net)
  • Nephrotoxicity most commonly affects tubulointerstitial compartment and manifests either acute tubular injury (ATI) or acute interstitial nephritis (AIN). (intechopen.com)
  • Autonomic dysreflexia is a life-threatening reflex action that primarily affects those with injuries to the neck or upper back. (rxlist.com)
  • When injury or illness affects the musculoskeletal system, the experienced and skilled orthopaedic team at the University of Chicago Medicine offers the full spectrum of nonsurgical and surgical care. (uchospitals.edu)
  • When they blocked the neutrophil response, nearby nerve function was unaffected and when they increased neutrophils, it decreased function - at least initially - in injured and nearby uninjured nerves. (scienceblog.com)
  • The problem may be that the nerve and taste bud are slower to reconnect, so one of her follow-up studies will be looking at affected nerves as well as well as the form and function of axons, or arms, nerves use to reach out to another cell. (scienceblog.com)
  • Thin-film implants were used to deliver brief electrical stimulation (1 hour, 20 Hz) to sciatic nerves after nerve crush or nerve transection-and-repair injuries. (thejns.org)
  • Microinjecting recombinant IL-1β or TNF at the site of sciatic nerve injury in IL-1β- and TNF-knock-out mice restored mechanical pain thresholds back to levels observed in injured wild-type mice. (jneurosci.org)
  • Importantly, recovery of sciatic nerve function was impaired in IL-1β-, TNF-, and IL-1β/TNF-knock-out mice. (jneurosci.org)
  • The clinical presentation, including ECGs and findings on catheterization as well as the rapid recovery of ventricular function, is consistent with the diagnosis of takotsubo cardiomyopathy. (dovepress.com)
  • These findings are consistent with the results of previous studies, and confirm the capacity of REAC-TO to provide almost immediate recovery of function in traumatized areas. (dovepress.com)
  • His findings also hold important implications for military personnel exposed to blast injury. (columbia.edu)
  • Our findings support current conceptual models of coma as being caused by subcortical AAn injury. (harvard.edu)
  • Clinical reports and available research suggest residual problems in cognition, attention, executive function, and memory. (aappublications.org)
  • Extracting 30~40%Ï of fatty acid in the hemp seed, it can be made of hemp oil capsule with health function and the residual oil is available to be made biodiesel. (epier.com)
  • This may deprive the cell body in dorsal root ganglia of a greater amount of the nerve axon, possibly reducing expression of mediators of pain distal to the injury, more akin to an avulsion-type nerve injury. (asahq.org)
  • Rapid diagnosis and management are essential to have the highest chances of preventing permanent loss of function. (ottobock.co.uk)
  • What Causes a Brachial Plexus Injury? (chp.edu)
  • Brachial Plexus injury expert specializing in erb's palsy and brachial plexus palsy treatment. (drnathbrachialplexus.com)
  • Typically, most recovery of muscle strength occurs in the first year of life. (chp.edu)
  • When researchers blocked the function of this gene in old mice, they reset the old brain to adolescent levels of plasticity. (yale.edu)
  • Plasticity in intrinsic excitability may play multiple important roles in the functioning nervous system. (biologists.org)
  • This `homeostatic plasticity' has more recently been implicated as a mechanism of stabilizing neuronal function. (biologists.org)
  • We previously demonstrated that EVs derived from human MSCs accelerated recovery following acute kidney injury (AKI) in vivo. (spandidos-publications.com)
  • confounders may include degree of injury and concomitant endothelial dysfunction. (hindawi.com)
  • It is estimated that 95% of severe intracranial injuries and 64% of all head injuries in children 1 year of age or younger are caused by violence inflicted by parents or caretakers. (netce.com)
  • This course is designed for all healthcare professionals who may intervene to prevent or identify pediatric abusive head injuries. (netce.com)
  • So it was in an attempt to shorten the recovery time from common injuries that the German National Hockey Team began experimenting in the early 1990s with a substance known as Wobenzym . (nutritionreview.org)
  • I'm a very impatient person,' he acknowledges, and was constantly pressing the doctor and therapists for how he could shorten the recovery timeline. (dailypress.com)
  • The likelihood of such an injury increases proportionately with age. (dailypress.com)
  • Aquatic therapy increases flexibility, function and endurance using aerobic, strengthening and conditioning components. (marshfieldclinic.org)
  • Obesity will make the recovery time much longer, and it will make the other knee more susceptible to future ligament injury or rupture. (vcahospitals.com)
  • The team believes this finding may suggest that 4AP could be used immediately after an injury to diagnose whether a nerve is severed, however further studies are required to determine if this will work in humans. (eurekalert.org)
  • In humans and other higher mammals, lack of sleep has been demonstrated to impact physical, cognitive and emotional functions negatively. (neuroskills.com)
  • Neurotmesis: this type of injury involves the endoneurium with wallerian degeneration. (wikipedia.org)
  • [2] A fourth-degree burn additionally involves injury to deeper tissues, such as muscle , tendons , or bone . (wikipedia.org)
  • Cruciate ligament injuries are common in dogs and considered relatively uncommon in cats. (vcahospitals.com)
  • A skilled surgeon can create a replacement ligament and stabilize the joint so it functions normally or nearly normally. (vcahospitals.com)
  • Takotsubo cardiomyopathy was first described in 1991, but the pathophysiology and exact mechanism of injury remain largely unknown. (dovepress.com)
  • These results identify CSC activation and new myocyte formation as an integral and essential component of the endogenous myocardial response to diffuse myocardial injury. (ahajournals.org)
  • Though the rodent literature provides a causal understanding of post-injury recovery mechanisms, it has had a limited impact on NIBS protocols in human research. (frontiersin.org)
  • This symposium will address novel mechanisms regulating lysosome function and approaches that harness innate lysosomal sensing to promote toxic protein clearance. (sfn.org)
  • Certain pathological conditions can interfere with the normal brain-heart regulatory mechanisms and result in impaired cardiovascular function. (ahajournals.org)
  • The mechanisms by which MSC exert these actions include the release of biomolecules with anti-inflammatory, immunomodulating, anti-fibrogenic, and trophic functions. (biomedcentral.com)
  • When injuries are at the C5 level and below, diaphragm function is preserved, but breathing tends to be rapid and shallow and people have trouble coughing and clearing secretions from their lungs because of weak thoracic muscles. (rxlist.com)
  • The time to onset of kidney injury varies considerably, ranging from a few days to weeks. (psychiatryadvisor.com)
  • Unfortunately, the cruciate damage, when left untreated, will result in a rapid onset of arthritis in the affected joint. (vcahospitals.com)
  • RRT initiated before the onset of severe AKI could potentially prevent the kidney-specific damage and remote organ injury resulting from fluid overload, electrolyte-metabolic imbalance, and systemic inflammation. (biomedcentral.com)
  • For example, the impulse to urinate can set off high blood pressure or rapid heart beat that, if uncontrolled, can cause stroke , seizures , or death. (rxlist.com)
  • This symposium will review new insights into how expanded repeats perturb multi-level function of the nervous system and discuss how emerging knowledge is driving creative and novel treatment strategies. (sfn.org)
  • It happens when there is an irritation, pain, or stimulus to the nervous system below the level of injury. (rxlist.com)
  • The swelling, pain, and immobility that follow such traumatic injuries not only leave the individual player feeling uncomfortable, they can diminish his performance or keep him out of action altogether. (nutritionreview.org)
  • In all cases, REAC-TO sessions were found to be effective for the treatment of post-traumatic injuries involving hematomas, hemorrhagic suffusion, and loss of function. (dovepress.com)
  • Adequate carbohydrates also are necessary for optimal brain functioning. (preparedfoods.com)
  • 7 years) severe injury associated with poor recovery and late (≥8 years), severe TBI or early, mild TBI characterized by better recovery. (aappublications.org)
  • If your child doesn't have signs of a serious head injury, remains alert, moves normally and responds to you, the injury is probably mild and usually doesn't need further testing. (mayoclinic.org)
  • Arterial injury occurs in response to a wide variety of insults, including pathophysiological factors such as oxidised low-density lipoproteins, renin-angiotensin axis, and insulin resistance. (hindawi.com)
  • This injury occurs when you suffer a severe blow to the head. (hwnn.com)