Introduction of substances into the body using a needle and syringe.
Forceful administration into a muscle of liquid medication, nutrient, or other fluid through a hollow needle piercing the muscle and any tissue covering it.
Injections made into a vein for therapeutic or experimental purposes.
Injections introduced directly into localized lesions.
Forceful administration under the skin of liquid medication, nutrient, or other fluid through a hollow needle piercing the skin.
Methods of delivering drugs into a joint space.
Forceful administration into the peritoneal cavity of liquid medication, nutrient, or other fluid through a hollow needle piercing the abdominal wall.
The forcing into the skin of liquid medication, nutrient, or other fluid through a hollow needle, piercing the top skin layer.
The injection of drugs, most often analgesics, into the spinal canal without puncturing the dura mater.
Injections into the cerebral ventricles.
Delivery of drugs into an artery.
The administration of substances into the VITREOUS BODY of the eye with a hypodermic syringe.
Introduction of therapeutic agents into the spinal region using a needle and syringe.
The injection of solutions into the skin by compressed air devices so that only the solution pierces the skin.
The administration of substances into the eye with a hypodermic syringe.
Elements of limited time intervals, contributing to particular results or situations.
A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.
The analysis of a chemical substance by inserting a sample into a carrier stream of reagent using a sample injection valve that propels the sample downstream where mixing occurs in a coiled tube, then passes into a flow-through detector and a recorder or other data handling device.
The injection of very small amounts of fluid, often with the aid of a microscope and microsyringes.
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
Abuse, overuse, or misuse of a substance by its injection into a vein.
An assisted fertilization technique consisting of the microinjection of a single viable sperm into an extracted ovum. It is used principally to overcome low sperm count, low sperm motility, inability of sperm to penetrate the egg, or other conditions related to male infertility (INFERTILITY, MALE).
Instruments used for injecting or withdrawing fluids. (Stedman, 25th ed)
The relationship between the dose of an administered drug and the response of the organism to the drug.
Sharp instruments used for puncturing or suturing.
A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain.
Drugs that block nerve conduction when applied locally to nerve tissue in appropriate concentrations. They act on any part of the nervous system and on every type of nerve fiber. In contact with a nerve trunk, these anesthetics can cause both sensory and motor paralysis in the innervated area. Their action is completely reversible. (From Gilman AG, et. al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed) Nearly all local anesthetics act by reducing the tendency of voltage-dependent sodium channels to activate.
The transparent, semigelatinous substance that fills the cavity behind the CRYSTALLINE LENS of the EYE and in front of the RETINA. It is contained in a thin hyaloid membrane and forms about four fifths of the optic globe.
An esterified form of TRIAMCINOLONE. It is an anti-inflammatory glucocorticoid used topically in the treatment of various skin disorders. Intralesional, intramuscular, and intra-articular injections are also administered under certain conditions.
The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.
A glucocorticoid given, as the free alcohol or in esterified form, orally, intramuscularly, by local injection, by inhalation, or applied topically in the management of various disorders in which corticosteroids are indicated. (From Martindale, The Extra Pharmacopoeia, 30th ed, p739)
Accumulation of a drug or chemical substance in various organs (including those not relevant to its pharmacologic or therapeutic action). This distribution depends on the blood flow or perfusion rate of the organ, the ability of the drug to penetrate organ membranes, tissue specificity, protein binding. The distribution is usually expressed as tissue to plasma ratios.
Drugs used for their actions on skeletal muscle. Included are agents that act directly on skeletal muscle, those that alter neuromuscular transmission (NEUROMUSCULAR BLOCKING AGENTS), and drugs that act centrally as skeletal muscle relaxants (MUSCLE RELAXANTS, CENTRAL). Drugs used in the treatment of movement disorders are ANTI-DYSKINESIA AGENTS.
A serotype of botulinum toxins that has specificity for cleavage of SYNAPTOSOMAL-ASSOCIATED PROTEIN 25.
Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations or by parent x offspring matings carried out with certain restrictions. This also includes animals with a long history of closed colony breeding.
A local anesthetic and cardiac depressant used as an antiarrhythmia agent. Its actions are more intense and its effects more prolonged than those of PROCAINE but its duration of action is shorter than that of BUPIVACAINE or PRILOCAINE.
A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.
Techniques and strategies which include the use of coding sequences and other conventional or radical means to transform or modify cells for the purpose of treating or reversing disease conditions.
Scales, questionnaires, tests, and other methods used to assess pain severity and duration in patients or experimental animals to aid in diagnosis, therapy, and physiological studies.
Usage of a single needle among two or more people for injecting drugs. Needle sharing is a high-risk behavior for contracting infectious disease.
An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.
DNA molecules capable of autonomous replication within a host cell and into which other DNA sequences can be inserted and thus amplified. Many are derived from PLASMIDS; BACTERIOPHAGES; or VIRUSES. They are used for transporting foreign genes into recipient cells. Genetic vectors possess a functional replicator site and contain GENETIC MARKERS to facilitate their selective recognition.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.
Substances used to allow enhanced visualization of tissues.
Experimental transplantation of neoplasms in laboratory animals for research purposes.
The various ways of administering a drug or other chemical to a site in a patient or animal from where the chemical is absorbed into the blood and delivered to the target tissue.
The introduction of functional (usually cloned) GENES into cells. A variety of techniques and naturally occurring processes are used for the gene transfer such as cell hybridization, LIPOSOMES or microcell-mediated gene transfer, ELECTROPORATION, chromosome-mediated gene transfer, TRANSFECTION, and GENETIC TRANSDUCTION. Gene transfer may result in genetically transformed cells and individual organisms.
The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
An encapsulated lymphatic organ through which venous blood filters.
The observable response an animal makes to any situation.
A process involving chance used in therapeutic trials or other research endeavor for allocating experimental subjects, human or animal, between treatment and control groups, or among treatment groups. It may also apply to experiments on inanimate objects.
Drugs used in the treatment of movement disorders. Most of these act centrally on dopaminergic or cholinergic systems. Among the most important clinically are those used for the treatment of Parkinson disease (ANTIPARKINSON AGENTS) and those for the tardive dyskinesias.
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations, or by parent x offspring matings carried out with certain restrictions. All animals within an inbred strain trace back to a common ancestor in the twentieth generation.
Mutant mice homozygous for the recessive gene "nude" which fail to develop a thymus. They are useful in tumor studies and studies on immune responses.
Compounds that are used in medicine as sources of radiation for radiotherapy and for diagnostic purposes. They have numerous uses in research and industry. (Martindale, The Extra Pharmacopoeia, 30th ed, p1161)
The basic cellular units of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the NERVOUS SYSTEM.
The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Female germ cells derived from OOGONIA and termed OOCYTES when they enter MEIOSIS. The primary oocytes begin meiosis but are arrested at the diplotene state until OVULATION at PUBERTY to give rise to haploid secondary oocytes or ova (OVUM).
People who take drugs for a non-therapeutic or non-medical effect. The drugs may be legal or illegal, but their use often results in adverse medical, legal, or social consequences for the users.
Lipid-containing polysaccharides which are endotoxins and important group-specific antigens. They are often derived from the cell wall of gram-negative bacteria and induce immunoglobulin secretion. The lipopolysaccharide molecule consists of three parts: LIPID A, core polysaccharide, and O-specific chains (O ANTIGENS). When derived from Escherichia coli, lipopolysaccharides serve as polyclonal B-cell mitogens commonly used in laboratory immunology. (From Dorland, 28th ed)
Unstable isotopes of iodine that decay or disintegrate emitting radiation. I atoms with atomic weights 117-139, except I 127, are radioactive iodine isotopes.
Apparatus, devices, or supplies intended for one-time or temporary use.
A family of non-enveloped viruses infecting mammals (MASTADENOVIRUS) and birds (AVIADENOVIRUS) or both (ATADENOVIRUS). Infections may be asymptomatic or result in a variety of diseases.
Refers to animals in the period of time just after birth.
An antigen solution emulsified in mineral oil. The complete form is made up of killed, dried mycobacteria, usually M. tuberculosis, suspended in the oil phase. It is effective in stimulating cell-mediated immunity (IMMUNITY, CELLULAR) and potentiates the production of certain IMMUNOGLOBULINS in some animals. The incomplete form does not contain mycobacteria.
An increased sensation of pain or discomfort produced by mimimally noxious stimuli due to damage to soft tissue containing NOCICEPTORS or injury to a peripheral nerve.
Substances that reduce or suppress INFLAMMATION.
Viscoelastic solutions that are injected into JOINTS in order to alleviate symptoms of joint-related disorders such as OSTEOARTHRITIS.
Antibodies produced by a single clone of cells.
Any of the ruminant mammals with curved horns in the genus Ovis, family Bovidae. They possess lachrymal grooves and interdigital glands, which are absent in GOATS.
A group of CORTICOSTEROIDS that affect carbohydrate metabolism (GLUCONEOGENESIS, liver glycogen deposition, elevation of BLOOD SUGAR), inhibit ADRENOCORTICOTROPIC HORMONE secretion, and possess pronounced anti-inflammatory activity. They also play a role in fat and protein metabolism, maintenance of arterial blood pressure, alteration of the connective tissue response to injury, reduction in the number of circulating lymphocytes, and functioning of the central nervous system.
Experimentally induced new abnormal growth of TISSUES in animals to provide models for studying human neoplasms.
Proteins prepared by recombinant DNA technology.
A statistical technique that isolates and assesses the contributions of categorical independent variables to variation in the mean of a continuous dependent variable.
The major progestational steroid that is secreted primarily by the CORPUS LUTEUM and the PLACENTA. Progesterone acts on the UTERUS, the MAMMARY GLANDS and the BRAIN. It is required in EMBRYO IMPLANTATION; PREGNANCY maintenance, and the development of mammary tissue for MILK production. Progesterone, converted from PREGNENOLONE, also serves as an intermediate in the biosynthesis of GONADAL STEROID HORMONES and adrenal CORTICOSTEROIDS.
Organized services for exchange of sterile needles and syringes used for injections as a potential means of reducing the transmission of infectious diseases.
A major gonadotropin secreted by the adenohypophysis (PITUITARY GLAND, ANTERIOR). Luteinizing hormone regulates steroid production by the interstitial cells of the TESTIS and the OVARY. The preovulatory LUTEINIZING HORMONE surge in females induces OVULATION, and subsequent LUTEINIZATION of the follicle. LUTEINIZING HORMONE consists of two noncovalently linked subunits, alpha and beta. Within a species, the alpha subunit is common in the three pituitary glycoprotein hormones (TSH, LH and FSH), but the beta subunit is unique and confers its biological specificity.
The measure of the level of heat of a human or animal.
Interruption of NEURAL CONDUCTION in peripheral nerves or nerve trunks by the injection of a local anesthetic agent (e.g., LIDOCAINE; PHENOL; BOTULINUM TOXINS) to manage or treat pain.
Body organ that filters blood for the secretion of URINE and that regulates ion concentrations.
An assisted reproductive technique that includes the direct handling and manipulation of oocytes and sperm to achieve fertilization in vitro.
The making of a radiograph of an object or tissue by recording on a photographic plate the radiation emitted by radioactive material within the object. (Dorland, 27th ed)
Chemical agents injected into blood vessels and lymphatic sinuses to shrink or cause localized THROMBOSIS; FIBROSIS, and obliteration of the vessels. This treatment is applied in a number of conditions such as VARICOSE VEINS; HEMORRHOIDS; GASTRIC VARICES; ESOPHAGEAL VARICES; PEPTIC ULCER HEMORRHAGE.
The 17-beta-isomer of estradiol, an aromatized C18 steroid with hydroxyl group at 3-beta- and 17-beta-position. Estradiol-17-beta is the most potent form of mammalian estrogenic steroids.
The outer covering of the body that protects it from the environment. It is composed of the DERMIS and the EPIDERMIS.
A cylindrical column of tissue that lies within the vertebral canal. It is composed of WHITE MATTER and GRAY MATTER.
Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.
PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS.
Volume of biological fluid completely cleared of drug metabolites as measured in unit time. Elimination occurs as a result of metabolic processes in the kidney, liver, saliva, sweat, intestine, heart, brain, or other site.
A water-soluble extractive mixture of sulfated polysaccharides from RED ALGAE. Chief sources are the Irish moss CHONDRUS CRISPUS (Carrageen), and Gigartina stellata. It is used as a stabilizer, for suspending COCOA in chocolate manufacture, and to clarify BEVERAGES.
The domestic cat, Felis catus, of the carnivore family FELIDAE, comprising over 30 different breeds. The domestic cat is descended primarily from the wild cat of Africa and extreme southwestern Asia. Though probably present in towns in Palestine as long ago as 7000 years, actual domestication occurred in Egypt about 4000 years ago. (From Walker's Mammals of the World, 6th ed, p801)
Injections into the lymph nodes or the lymphatic system.
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
A genus of the family PARVOVIRIDAE, subfamily PARVOVIRINAE, which are dependent on a coinfection with helper adenoviruses or herpesviruses for their efficient replication. The type species is Adeno-associated virus 2.
Time schedule for administration of a drug in order to achieve optimum effectiveness and convenience.
The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.
Abnormal fluid accumulation in TISSUES or body cavities. Most cases of edema are present under the SKIN in SUBCUTANEOUS TISSUE.
Compounds capable of relieving pain without the loss of CONSCIOUSNESS.
Any of various animals that constitute the family Suidae and comprise stout-bodied, short-legged omnivorous mammals with thick skin, usually covered with coarse bristles, a rather long mobile snout, and small tail. Included are the genera Babyrousa, Phacochoerus (wart hogs), and Sus, the latter containing the domestic pig (see SUS SCROFA).
One of three principal openings in the SUBARACHNOID SPACE. They are also known as cerebellomedullary cistern, and collectively as cisterns.
Further or repeated use of equipment, instruments, devices, or materials. It includes additional use regardless of the original intent of the producer as to disposability or durability. It does not include the repeated use of fluids or solutions.
Deliberate stimulation of the host's immune response. ACTIVE IMMUNIZATION involves administration of ANTIGENS or IMMUNOLOGIC ADJUVANTS. PASSIVE IMMUNIZATION involves administration of IMMUNE SERA or LYMPHOCYTES or their extracts (e.g., transfer factor, immune RNA) or transplantation of immunocompetent cell producing tissue (thymus or bone marrow).
The ten-layered nervous tissue membrane of the eye. It is continuous with the OPTIC NERVE and receives images of external objects and transmits visual impulses to the brain. Its outer surface is in contact with the CHOROID and the inner surface with the VITREOUS BODY. The outer-most layer is pigmented, whereas the inner nine layers are transparent.
Ventral part of the DIENCEPHALON extending from the region of the OPTIC CHIASM to the caudal border of the MAMMILLARY BODIES and forming the inferior and lateral walls of the THIRD VENTRICLE.
The principal alkaloid in opium and the prototype opiate analgesic and narcotic. Morphine has widespread effects in the central nervous system and on smooth muscle.
A PREDNISOLONE derivative with similar anti-inflammatory action.
A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.
A blocking of nerve conduction to a specific area by an injection of an anesthetic agent.
The number of CELLS of a specific kind, usually measured per unit volume or area of sample.
A method of studying a drug or procedure in which both the subjects and investigators are kept unaware of who is actually getting which specific treatment.
The measurement of an organ in volume, mass, or heaviness.
The first artificially produced element and a radioactive fission product of URANIUM. Technetium has the atomic symbol Tc, atomic number 43, and atomic weight 98.91. All technetium isotopes are radioactive. Technetium 99m (m=metastable) which is the decay product of Molybdenum 99, has a half-life of about 6 hours and is used diagnostically as a radioactive imaging agent. Technetium 99 which is a decay product of technetium 99m, has a half-life of 210,000 years.
A widely used local anesthetic agent.
Either of two extremities of four-footed non-primate land animals. It usually consists of a FEMUR; TIBIA; and FIBULA; tarsals; METATARSALS; and TOES. (From Storer et al., General Zoology, 6th ed, p73)
The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.
A group of glucose polymers made by certain bacteria. Dextrans are used therapeutically as plasma volume expanders and anticoagulants. They are also commonly used in biological experimentation and in industry for a wide variety of purposes.
Mature male germ cells derived from SPERMATIDS. As spermatids move toward the lumen of the SEMINIFEROUS TUBULES, they undergo extensive structural changes including the loss of cytoplasm, condensation of CHROMATIN into the SPERM HEAD, formation of the ACROSOME cap, the SPERM MIDPIECE and the SPERM TAIL that provides motility.
A decapeptide that stimulates the synthesis and secretion of both pituitary gonadotropins, LUTEINIZING HORMONE and FOLLICLE STIMULATING HORMONE. GnRH is produced by neurons in the septum PREOPTIC AREA of the HYPOTHALAMUS and released into the pituitary portal blood, leading to stimulation of GONADOTROPHS in the ANTERIOR PITUITARY GLAND.
Small uniformly-sized spherical particles, of micrometer dimensions, frequently labeled with radioisotopes or various reagents acting as tags or markers.
Four CSF-filled (see CEREBROSPINAL FLUID) cavities within the cerebral hemispheres (LATERAL VENTRICLES), in the midline (THIRD VENTRICLE) and within the PONS and MEDULLA OBLONGATA (FOURTH VENTRICLE).
The physical activity of a human or an animal as a behavioral phenomenon.
Domesticated bovine animals of the genus Bos, usually kept on a farm or ranch and used for the production of meat or dairy products or for heavy labor.
Diabetes mellitus induced experimentally by administration of various diabetogenic agents or by PANCREATECTOMY.
The production of ANTIBODIES by proliferating and differentiated B-LYMPHOCYTES under stimulation by ANTIGENS.
A group of polycyclic compounds closely related biochemically to TERPENES. They include cholesterol, numerous hormones, precursors of certain vitamins, bile acids, alcohols (STEROLS), and certain natural drugs and poisons. Steroids have a common nucleus, a fused, reduced 17-carbon atom ring system, cyclopentanoperhydrophenanthrene. Most steroids also have two methyl groups and an aliphatic side-chain attached to the nucleus. (From Hawley's Condensed Chemical Dictionary, 11th ed)
Toxins closely associated with the living cytoplasm or cell wall of certain microorganisms, which do not readily diffuse into the culture medium, but are released upon lysis of the cells.
The rate dynamics in chemical or physical systems.
Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood.
Isotopes that exhibit radioactivity and undergo radioactive decay. (From Grant & Hackh's Chemical Dictionary, 5th ed & McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
The time it takes for a substance (drug, radioactive nuclide, or other) to lose half of its pharmacologic, physiologic, or radiologic activity.
Transplantation between animals of different species.
Production of an image when x-rays strike a fluorescent screen.
Immunoglobulin molecules having a specific amino acid sequence by virtue of which they interact only with the ANTIGEN (or a very similar shape) that induced their synthesis in cells of the lymphoid series (especially PLASMA CELLS).
Laboratory mice that have been produced from a genetically manipulated EGG or EMBRYO, MAMMALIAN.
Non-human animals, selected because of specific characteristics, for use in experimental research, teaching, or testing.
An alkylamide found in CAPSICUM that acts at TRPV CATION CHANNELS.
Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.
Toxic proteins produced from the species CLOSTRIDIUM BOTULINUM. The toxins are synthesized as a single peptide chain which is processed into a mature protein consisting of a heavy chain and light chain joined via a disulfide bond. The botulinum toxin light chain is a zinc-dependent protease which is released from the heavy chain upon ENDOCYTOSIS into PRESYNAPTIC NERVE ENDINGS. Once inside the cell the botulinum toxin light chain cleaves specific SNARE proteins which are essential for secretion of ACETYLCHOLINE by SYNAPTIC VESICLES. This inhibition of acetylcholine release results in muscular PARALYSIS.
Disease involving a spinal nerve root (see SPINAL NERVE ROOTS) which may result from compression related to INTERVERTEBRAL DISK DISPLACEMENT; SPINAL CORD INJURIES; SPINAL DISEASES; and other conditions. Clinical manifestations include radicular pain, weakness, and sensory loss referable to structures innervated by the involved nerve root.
A specific opiate antagonist that has no agonist activity. It is a competitive antagonist at mu, delta, and kappa opioid receptors.
An alkaloid ester extracted from the leaves of plants including coca. It is a local anesthetic and vasoconstrictor and is clinically used for that purpose, particularly in the eye, ear, nose, and throat. It also has powerful central nervous system effects similar to the amphetamines and is a drug of abuse. Cocaine, like amphetamines, acts by multiple mechanisms on brain catecholaminergic neurons; the mechanism of its reinforcing effects is thought to involve inhibition of dopamine uptake.
A range of methods used to reduce pain and anxiety during dental procedures.
The property of blood capillary ENDOTHELIUM that allows for the selective exchange of substances between the blood and surrounding tissues and through membranous barriers such as the BLOOD-AIR BARRIER; BLOOD-AQUEOUS BARRIER; BLOOD-BRAIN BARRIER; BLOOD-NERVE BARRIER; BLOOD-RETINAL BARRIER; and BLOOD-TESTIS BARRIER. Small lipid-soluble molecules such as carbon dioxide and oxygen move freely by diffusion. Water and water-soluble molecules cannot pass through the endothelial walls and are dependent on microscopic pores. These pores show narrow areas (TIGHT JUNCTIONS) which may limit large molecule movement.
A natural high-viscosity mucopolysaccharide with alternating beta (1-3) glucuronide and beta (1-4) glucosaminidic bonds. It is found in the UMBILICAL CORD, in VITREOUS BODY and in SYNOVIAL FLUID. A high urinary level is found in PROGERIA.
The major immunoglobulin isotype class in normal human serum. There are several isotype subclasses of IgG, for example, IgG1, IgG2A, and IgG2B.
Management, removal, and elimination of biologic, infectious, pathologic, and dental waste. The concept includes blood, mucus, tissue removed at surgery or autopsy, soiled surgical dressings, and other materials requiring special control and handling. Disposal may take place where the waste is generated or elsewhere.
Organic compounds that contain technetium as an integral part of the molecule. These compounds are often used as radionuclide imaging agents.
A polypeptide that is secreted by the adenohypophysis (PITUITARY GLAND, ANTERIOR). Growth hormone, also known as somatotropin, stimulates mitosis, cell differentiation and cell growth. Species-specific growth hormones have been synthesized.
The discharge of an OVUM from a rupturing follicle in the OVARY.
Agents and endogenous substances that antagonize or inhibit the development of new blood vessels.
Chinese herbal or plant extracts which are used as drugs to treat diseases or promote general well-being. The concept does not include synthesized compounds manufactured in China.
The transfer of mammalian embryos from an in vivo or in vitro environment to a suitable host to improve pregnancy or gestational outcome in human or animal. In human fertility treatment programs, preimplantation embryos ranging from the 4-cell stage to the blastocyst stage are transferred to the uterine cavity between 3-5 days after FERTILIZATION IN VITRO.
Serum glycoprotein produced by activated MACROPHAGES and other mammalian MONONUCLEAR LEUKOCYTES. It has necrotizing activity against tumor cell lines and increases ability to reject tumor transplants. Also known as TNF-alpha, it is only 30% homologous to TNF-beta (LYMPHOTOXIN), but they share TNF RECEPTORS.
The number of times the HEART VENTRICLES contract per unit of time, usually per minute.
They are oval or bean shaped bodies (1 - 30 mm in diameter) located along the lymphatic system.
A clear, colorless liquid rapidly absorbed from the gastrointestinal tract and distributed throughout the body. It has bactericidal activity and is used often as a topical disinfectant. It is widely used as a solvent and preservative in pharmaceutical preparations as well as serving as the primary ingredient in ALCOHOLIC BEVERAGES.
A biochemical messenger and regulator, synthesized from the essential amino acid L-TRYPTOPHAN. In humans it is found primarily in the central nervous system, gastrointestinal tract, and blood platelets. Serotonin mediates several important physiological functions including neurotransmission, gastrointestinal motility, hemostasis, and cardiovascular integrity. Multiple receptor families (RECEPTORS, SEROTONIN) explain the broad physiological actions and distribution of this biochemical mediator.
Mice homozygous for the mutant autosomal recessive gene "scid" which is located on the centromeric end of chromosome 16. These mice lack mature, functional lymphocytes and are thus highly susceptible to lethal opportunistic infections if not chronically treated with antibiotics. The lack of B- and T-cell immunity resembles severe combined immunodeficiency (SCID) syndrome in human infants. SCID mice are useful as animal models since they are receptive to implantation of a human immune system producing SCID-human (SCID-hu) hematochimeric mice.
A 51-amino acid pancreatic hormone that plays a major role in the regulation of glucose metabolism, directly by suppressing endogenous glucose production (GLYCOGENOLYSIS; GLUCONEOGENESIS) and indirectly by suppressing GLUCAGON secretion and LIPOLYSIS. Native insulin is a globular protein comprised of a zinc-coordinated hexamer. Each insulin monomer containing two chains, A (21 residues) and B (30 residues), linked by two disulfide bonds. Insulin is used as a drug to control insulin-dependent diabetes mellitus (DIABETES MELLITUS, TYPE 1).
Substances that augment, stimulate, activate, potentiate, or modulate the immune response at either the cellular or humoral level. The classical agents (Freund's adjuvant, BCG, Corynebacterium parvum, et al.) contain bacterial antigens. Some are endogenous (e.g., histamine, interferon, transfer factor, tuftsin, interleukin-1). Their mode of action is either non-specific, resulting in increased immune responsiveness to a wide variety of antigens, or antigen-specific, i.e., affecting a restricted type of immune response to a narrow group of antigens. The therapeutic efficacy of many biological response modifiers is related to their antigen-specific immunoadjuvanticity.
A major gonadotropin secreted by the adenohypophysis (PITUITARY GLAND, ANTERIOR). Follicle-stimulating hormone stimulates GAMETOGENESIS and the supporting cells such as the ovarian GRANULOSA CELLS, the testicular SERTOLI CELLS, and LEYDIG CELLS. FSH consists of two noncovalently linked subunits, alpha and beta. Within a species, the alpha subunit is common in the three pituitary glycoprotein hormones (TSH, LH, and FSH), but the beta subunit is unique and confers its biological specificity.
Use of electric potential or currents to elicit biological responses.
The active sympathomimetic hormone from the ADRENAL MEDULLA. It stimulates both the alpha- and beta- adrenergic systems, causes systemic VASOCONSTRICTION and gastrointestinal relaxation, stimulates the HEART, and dilates BRONCHI and cerebral vessels. It is used in ASTHMA and CARDIAC FAILURE and to delay absorption of local ANESTHETICS.
Compounds with activity like OPIATE ALKALOIDS, acting at OPIOID RECEPTORS. Properties include induction of ANALGESIA or NARCOSIS.
Chemicals and substances that impart color including soluble dyes and insoluble pigments. They are used in INKS; PAINTS; and as INDICATORS AND REAGENTS.
Dosage forms of a drug that act over a period of time by controlled-release processes or technology.
Procedures for the improvement or enhancement of the appearance of the visible parts of the body.
Unstable isotopes of indium that decay or disintegrate emitting radiation. In atoms with atomic weights 106-112, 113m, 114, and 116-124 are radioactive indium isotopes.
An enzyme isolated from horseradish which is able to act as an antigen. It is frequently used as a histochemical tracer for light and electron microscopy. Its antigenicity has permitted its use as a combined antigen and marker in experimental immunology.
One of the catecholamine NEUROTRANSMITTERS in the brain. It is derived from TYROSINE and is the precursor to NOREPINEPHRINE and EPINEPHRINE. Dopamine is a major transmitter in the extrapyramidal system of the brain, and important in regulating movement. A family of receptors (RECEPTORS, DOPAMINE) mediate its action.
Peripheral AFFERENT NEURONS which are sensitive to injuries or pain, usually caused by extreme thermal exposures, mechanical forces, or other noxious stimuli. Their cell bodies reside in the DORSAL ROOT GANGLIA. Their peripheral terminals (NERVE ENDINGS) innervate target tissues and transduce noxious stimuli via axons to the CENTRAL NERVOUS SYSTEM.
Artificial, single or multilaminar vesicles (made from lecithins or other lipids) that are used for the delivery of a variety of biological molecules or molecular complexes to cells, for example, drug delivery and gene transfer. They are also used to study membranes and membrane proteins.
Glucose in blood.
The period in the ESTROUS CYCLE associated with maximum sexual receptivity and fertility in non-primate female mammals.
A ubiquitous sodium salt that is commonly used to season food.
Systems for the delivery of drugs to target sites of pharmacological actions. Technologies employed include those concerning drug preparation, route of administration, site targeting, metabolism, and toxicity.
A tissue adhesive that is applied as a monomer to moist tissue and polymerizes to form a bond. It is slowly biodegradable and used in all kinds of surgery, including dental.
A class of compounds of the type R-M, where a C atom is joined directly to any other element except H, C, N, O, F, Cl, Br, I, or At. (Grant & Hackh's Chemical Dictionary, 5th ed)
Treatment of varicose veins, hemorrhoids, gastric and esophageal varices, and peptic ulcer hemorrhage by injection or infusion of chemical agents which cause localized thrombosis and eventual fibrosis and obliteration of the vessels.
A subtype of striated muscle, attached by TENDONS to the SKELETON. Skeletal muscles are innervated and their movement can be consciously controlled. They are also called voluntary muscles.
Microscopy using an electron beam, instead of light, to visualize the sample, thereby allowing much greater magnification. The interactions of ELECTRONS with specimens are used to provide information about the fine structure of that specimen. In TRANSMISSION ELECTRON MICROSCOPY the reactions of the electrons that are transmitted through the specimen are imaged. In SCANNING ELECTRON MICROSCOPY an electron beam falls at a non-normal angle on the specimen and the image is derived from the reactions occurring above the plane of the specimen.
The relatively long-lived phagocytic cell of mammalian tissues that are derived from blood MONOCYTES. Main types are PERITONEAL MACROPHAGES; ALVEOLAR MACROPHAGES; HISTIOCYTES; KUPFFER CELLS of the liver; and OSTEOCLASTS. They may further differentiate within chronic inflammatory lesions to EPITHELIOID CELLS or may fuse to form FOREIGN BODY GIANT CELLS or LANGHANS GIANT CELLS. (from The Dictionary of Cell Biology, Lackie and Dow, 3rd ed.)
A neurotoxic isoxazole isolated from species of AMANITA. It is obtained by decarboxylation of IBOTENIC ACID. Muscimol is a potent agonist of GABA-A RECEPTORS and is used mainly as an experimental tool in animal and tissue studies.
ARTHRITIS that is induced in experimental animals. Immunological methods and infectious agents can be used to develop experimental arthritis models. These methods include injections of stimulators of the immune response, such as an adjuvant (ADJUVANTS, IMMUNOLOGIC) or COLLAGEN.
A gonadotropic glycoprotein hormone produced primarily by the PLACENTA. Similar to the pituitary LUTEINIZING HORMONE in structure and function, chorionic gonadotropin is involved in maintaining the CORPUS LUTEUM during pregnancy. CG consists of two noncovalently linked subunits, alpha and beta. Within a species, the alpha subunit is virtually identical to the alpha subunits of the three pituitary glycoprotein hormones (TSH, LH, and FSH), but the beta subunit is unique and confers its biological specificity (CHORIONIC GONADOTROPIN, BETA SUBUNIT, HUMAN).
A common name used for the genus Cavia. The most common species is Cavia porcellus which is the domesticated guinea pig used for pets and biomedical research.
A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.
Forms to which substances are incorporated to improve the delivery and the effectiveness of drugs. Drug carriers are used in drug-delivery systems such as the controlled-release technology to prolong in vivo drug actions, decrease drug metabolism, and reduce drug toxicity. Carriers are also used in designs to increase the effectiveness of drug delivery to the target sites of pharmacological actions. Liposomes, albumin microspheres, soluble synthetic polymers, DNA complexes, protein-drug conjugates, and carrier erythrocytes among others have been employed as biodegradable drug carriers.
Abrupt changes in the membrane potential that sweep along the CELL MEMBRANE of excitable cells in response to excitation stimuli.
The lower portion of the BRAIN STEM. It is inferior to the PONS and anterior to the CEREBELLUM. Medulla oblongata serves as a relay station between the brain and the spinal cord, and contains centers for regulating respiratory, vasomotor, cardiac, and reflex activities.
Liquid chromatographic techniques which feature high inlet pressures, high sensitivity, and high speed.

A review of the pharmacology, pharmacokinetics and behavioral effects of procaine in thoroughbred horses. (1/3876)

Since procaine has both local anaesthetic and central stimulant actions its presence in the blood or urine of racing horses is forbidden. After rapid intravenous injection of procaine HC1 (2.5 mg/Kg) in thoroughbred mares plasma levels of this drug fell rapidly (t 1/2 alpha = 5 min) and then more slowly (t 1/2 beta = 50.2 min). These kinetics were well fitted by a two compartment open model (Model I). This model gave an apparent Vdbeta for procaine in the horse of about 3,500 litres. Since procaine was about 45% bound to equine plasma protein this gives a true Vdbeta for procaine of about 6,500 litres. After subcutaneous injection of procaine HC1 (3.3 mg/Kg) plasma levels peaked at about 400 ng/ml and then declined with a half-life of about 75 minutes. These data were well fitted by Model I when this was modified to include simple first order absorption (K = 0.048 min-1) from the subcutaneous injection site (Model II). After intramuscular injection of procaine penicillin (33,000 I.U./Kg) plasma levels reached a peak at about 270 ng/ml and then declined with a half-life of about 9 hours. These data were approximately fitted by Model II assuming a first order rate constant for absorption of procaine of 0.0024 min-1. After intramuscular injection of procaine HC1 (10 mg/Kg) plasma levels of procaine peaked rapidly at about 600 ng/ml but thereafter declined slowly (+ 1/2 = 2 hours). A satisfactory pharmaco-kinetic model for this intramuscular data could not be developed. An approximation of these data was obtained by assuming the existence of two intramuscular drug compartments, one containing readily absorbable drug and the other poorly absorbable drug (Model III). After intra-articular administration of procaine (0.33 mg/Kg) plasma levels of this drug reached a peak at about 17 ng/ml and then declined with a half-life of about 2 hours. These data were not modelled.  (+info)

Serum ampicillin levels in the calf: influence of dosage, route of administration and dosage form. (2/3876)

Holstein bull calves received ampicillin sodium by the intravenous, intramuscular and subcutaneous routes and ampicillin trihydrate by the intramuscular route, at a dosage of 5 mg/kg. In addition ampicillin sodium and ampicillin trihydrate were given at a 12 mg/kg dosage intramuscularly. The serum ampicillin concentrations were determined at five, 30, 60, 120, 180, 240 and 300 min after drug administration and at 360 min after ampicillin trihydrate injection. Intravenous administration gave a high initial level (16.2 mug/ml) at five min that declined to below 1 mug/ml by 120 min. Subcutaneous administration produced the lowest initial levels of drug but concentrations of drug detected did not differ significantly from the intramuscular administration at any sampling interval. The 12 mg/kg intramuscular ampicillin sodium dosage produced significantly higher levels than the 5 mg/kg dosage only at five min. Ampicillin trihydrate gave higher levels than ampicillin sodium at all times except 30 min (5 mg/kg) and five min (12 mg/kg). The serum ampicillin disappearance study (5 mg/kg intravenous) gave a two component bi-exponential curve. Kinetic analysis of the first component showed a C01 (theoretical initial conc) of 44.8 mug/ml, a ke1 (rate constant of disappearance) of 0.064 mug min and a t1/21 (calculated half-life) of 10.8 min. The Co2, ke2 and t1/22 of the second component were 6.2 mug/ml, 0.0157 mug/min and 46.2 min respectively.  (+info)

Tissue pharmacokinetics, inhibition of DNA synthesis and tumor cell kill after high-dose methotrexate in murine tumor models. (3/3876)

In Sarcoma 180 and L1210 ascites tumor models, the initial rate of methotrexate accumulation in tumor cells in the peritoneal cavity and in small intestine (intracellularly) after s.c. doses up to 800 mg/kg, showed saturation kinetics. These results and the fact that initial uptake in these tissues within this dosage range was inhibited to the expected relative extent by the simultaneous administration of leucovorin suggest that carrier mediation and not passive diffusion is the major route of drug entry at these extremely high doses. Maximum accumulation of intracellular drug occurred within 2 hr and reached much higher levels in small intestine than in tumor cells at the higher dosages. At a 3-mg/kg dose of methotrexate s.c., intracellular exchangeable drug levels persisted more than four times longer in L1210 cells than in small intestine, but differences in persistence (L1210 cell versus gut) diminished markedly with increasing dosage. At 96 mg/kg, the difference in persistence was less than 2-fold. In small intestine and L1210 cells, theduration of inhibition of DNA synthesis at different dosages correlated with the extent to which exchangeable drug was retained. Toxic deaths occurred when inhibition in small intestine lasted longer than 25 to 30 hr. Recovery of synthesis in small intestine and L1210 cells occurred synchronously and only below dosages of 400 mg/kg. Within 24 hr after dosages of greater than 24 mg/kg, the rate of tumor cell loss increased to a point characterized by a single exponential (t1/2=8.5 hr). The total cell loss, but not the rate of cell loss, was dose dependent.  (+info)

Interferon-alpha does not improve outcome at one year in patients with diffuse cutaneous scleroderma: results of a randomized, double-blind, placebo-controlled trial. (4/3876)

OBJECTIVE: To determine whether interferon-alpha (IFNalpha) reduces the severity of skin involvement in early (<3 years) diffuse scleroderma. METHODS: In a randomized, placebo-controlled, double-blind trial, 35 patients with early scleroderma received subcutaneous injections of either IFNalpha (13.5 x 10(6) units per week in divided doses) or indistinguishable placebo. Outcomes assessed were the modified Rodnan skin score, as determined by a single observer at baseline, 6 months, and 12 months, as well as data on renal, cardiac, and lung function. Pre- and posttreatment skin biopsy samples were analyzed and blood was obtained for assessment of procollagen peptide levels. RESULTS: There were 11 withdrawals from the IFNalpha group and 3 from the placebo group due to either toxicity, lack of efficacy, or death. In the intent-to-treat analysis, there was a greater improvement in the skin score in the placebo group between 0 and 12 months (mean change IFNalpha -4.7 versus placebo -7.5; P = 0.36). There was also a greater deterioration in lung function in patients receiving active therapy, as assessed by either the forced vital capacity (mean change IFNalpha -8.2 versus placebo +1.3; P = 0.01) or the diffusing capacity for carbon monoxide (mean change IFNalpha -9.3 versus placebo +4.7; P = 0.002). Skin biopsy showed no significant decrease in collagen synthesis in the IFNalpha group, and no significant differences in the levels of procollagen peptides were seen between the 2 groups. CONCLUSION: This study suggests that IFNalpha is of no value in the treatment of scleroderma, and that it may in fact be deleterious.  (+info)

Spinal antinociceptive synergism between morphine and clonidine persists in mice made acutely or chronically tolerant to morphine. (5/3876)

Morphine (Mor) tolerance has been attributed to a reduction of opioid-adrenergic antinociceptive synergy at the spinal level. The present experiments tested the interaction of intrathecally (i.t.) administered Mor-clonidine (Clon) combinations in mice made acutely or chronically tolerant to Mor. ICR mice were pretreated with Mor either acutely (40 nmol i.t., 8 h; 100 mg/kg s.c., 4 h) or chronically (3 mg/kg s.c. every 6 h days 1 and 2; 5 mg/kg s.c. every 6 h days 3 and 4). Antinociception was detected via the hot water (52.5 degrees C) tail-flick test. After the tail-flick latencies returned to baseline levels, dose-response curves were generated to Mor, Clon, and Mor-Clon combinations in tolerant and control mice. Development of tolerance was confirmed by significant rightward shifts of the Mor dose-response curves in tolerant mice compared with controls. Isobolographic analysis was conducted; the experimental combined ED50 values were compared statistically against their respective theoretical additive ED50 values. In all Mor-pretreated groups, the combination of Mor and Clon resulted in significant leftward shifts in the dose-response curves compared with those of each agonist administered separately. In all tolerant and control groups, the combination of Mor and Clon produced an ED50 value significantly less than the corresponding theoretical additive ED50 value. Mor and Clon synergized in Mor-tolerant as well as in control mice. Spinally administered adrenergic/opioid synergistic combinations may be effective therapeutic strategies to manage pain in patients apparently tolerant to the analgesic effects of Mor.  (+info)

Effects of short-term administration of G-CSF (filgrastim) on bone marrow progenitor cells: analysis of serial marrow samples from normal donors. (6/3876)

To determine the effect of G-CSF administration on both the total number of CD34+ cells and the primitive CD34+ subsets in bone marrow (BM), we have analyzed BM samples serially obtained from 10 normal donors in steady-state and during G-CSF treatment. Filgrastim was administered subcutaneously at a dosage of 10 microg/kg/day (n = 7) or 10 microg/kg/12 h (n = 3) for 4 consecutive days. Peripheral blood sampling and BM aspirates were performed on day 1 (just before G-CSF administration), day 3 (after 2 days of G-CSF), and day 5 (after 4 days of G-CSF). During G-CSF administration, a significant increase in the total number of BM nucleated cells was observed. The percentage (range) of CD34+ cells decreased in BM from a median of 0.88 (0.47-1.44) on day 1 to 0.57 (0.32-1.87), and to 0.42 (0.16-0.87) on days 3 and 5, respectively. We observed a slight increase in the total number of BM CD34+ cells on day 3 (0.66 x 10(9)/l (0.13-0.77)), and a decrease on day 5 (0.23 x 10(9)/l (0.06-1.23)) as compared with steady-state (0.40 x 10(9)/l (0.06-1.68)). The proportion of primitive BM hematopoietic progenitor cells (CD34+CD38-, CD34+HLA-DR-, CD34+CD117-) decreased during G-CSF administration. In parallel, a significant increase in the total number of CD34+ cells in peripheral blood was observed, achieving the maximum value on day 5. These results suggest that in normal subjects the administration of G-CSF for 5 days may reduce the number of progenitor cells in BM, particularly the most primitive ones.  (+info)

In vivo activities of peptidic prodrugs of novel aminomethyl tetrahydrofuranyl-1 beta-methylcarbapenems. (7/3876)

A series of novel aminomethyl tetrahydrofuranyl (THF)-1 beta-methylcarbapenems which have excellent broad-spectrum antibacterial activities exhibit modest efficacies against acute lethal infections (3.8 mg/kg of body weight against Escherichia coli and 0.9 mg/kg against Staphylococcus aureus) in mice when they are administered orally. In an effort to improve the efficacies of orally administered drugs through enhanced absorption by making use of a peptide-mediated transport system, several different amino acids were added at the aminomethyl THF side chains of the carbapenem molecules. The resulting peptidic prodrugs with L-amino acids demonstrated improved efficacy after oral administration, while the D forms were less active than the parent molecules. After oral administration increased (3 to 10 times) efficacy was exhibited with the alanine-, valine-, isoleucine-, and phenylalanine-substituted prodrugs against acute lethal infections in mice. Median effective doses (ED50s) of < 1 mg/kg against infections caused by S. aureus, E. coli, Enterobacter cloacae, or penicillin-susceptible Streptococcus pneumoniae were obtained after the administration of single oral doses. Several of the peptidic prodrugs were efficacious against Morganella morganii, Serratia marcescens, penicillin-resistant S. pneumoniae, extended-spectrum beta-lactamase-producing Klebsiella pneumoniae, and E. coli infections, with ED50s of 1 to 14 mg/kg by oral administration compared with ED50s of 14 to > 32 mg/kg for the parent molecules. In general, the parent molecules demonstrated greater efficacy than the prodrugs against these same infections when the drugs were administered by the subcutaneous route. The parent molecule was detectable in the sera of mice after oral administration of the peptidic prodrugs.  (+info)

Long term orexigenic effect of a novel melanocortin 4 receptor selective antagonist. (8/3876)

1. We designed and synthesized several novel cyclic MSH analogues and tested their affinities for cells expressing the MC1, MC3, MC4 and MC5 receptors. 2. One of the substances HS028 (cyclic [AcCys11, dichloro-D-phenylalanine14, Cys18, Asp-NH2(22)]-beta-MSH11-22) showed high affinity (Ki of 0.95nM) and high (80 fold) MC4 receptor selectivity over the MC3 receptor. HS028 thus shows both higher affinity and higher selectivity for the MC4 receptor compared to the earlier first described MC4 receptor selective substance HS014. 3. HS028 antagonised a alpha-MSH induced increase in cyclic AMP production in transfected cells expressing the MC3 and MC4 receptors, whereas it seemed to be a partial agonist for the MC1 and MC5 receptors. 4. Chronic intracerebroventricularly (i.c.v.) administration of HS028 by osmotic minipumps significantly increased both food intake and body weight in a dose dependent manner without tachyphylaxis for a period of 7 days. 5. This is the first report demonstrating that an MC4 receptor antagonist can increase food intake and body weight during chronic administration providing further evidence that the MC4 receptor is an important mediator of long term weight homeostasis.  (+info)

Anakinra (Kineret), a recombinant form of human interleukin-1 (IL-1) receptor antagonist, is approved for the treatment of rheumatoid arthritis (RA) in combination with methotrexate. Kineret is self-administered by daily subcutaneous injections in patients with active RA. The mechanism of action of anakinra is to competitively inhibit the local inflammatory effects of IL-1. Kineret is generally safe and well tolerated and the only major treatment-related side effects that appear are skin reactions at the injection site. Due to the relatively short half-life of anakinra, daily injection of the drug is required. This, in combination with the comparably high rates of injection-site reactions (ISRs) associated with the drug, can become a problem for the patient. The present review summarises published data concerning ISRs associated with Kineret and provides some explanations as to their cause. The objective is also to present some clinical experiences of how the ISRs can be managed.. ...
Health,... PRINCETON N.J. Sept. 4 /- Novo Nordisk t... We are making these changes at a time when Novo Nordisk is doing well...During his 11 years with Novo Nordisk Gruhn has played a critical rol... North America is not only the worlds largest diabetes market butal...,Novo,Nordisk,Appoints,New,Leader,of,North,American,Business,medicine,medical news today,latest medical news,medical newsletters,current medical news,latest medicine news
CAM2038 q1w: BPN FluidCrystal® SC injection depot for once weekly administration (50 mg/mL) at doses of 8, 16, 24 or 32 mg (BPN base) (0.16, 0.32, 0.48 or 0.64 mL SC injection).. CAM2038 q4w: BPN FluidCrystal® SC injection depot for once monthly administration (356 mg/mL) at doses of 64, 96, 128 or 160 mg (BPN base) (0.18, 0.27, 0.36 or 0.45 mL SC injection).. SL placebo: tablets matching 2 mg/0.5 mg and 8 mg/2 mg SL BPN doses, administered daily ...
Novo Nordisk A/SNovo Nordisk A/S is a pharmaceutical company, created in 1989 by a mergerbetween Novo Industry A/S and Nordisk Gentofle A/S, specialized in themedications for diabetes, like insulin.The Novo Nordisk Foundation is a non-profit instituti...
Results. Mean maximum plasma TFPI levels approached 150-230 ng/ml at the 0.8 h and up to 5 h posttinzaparin dose compared to basal TFPI levels of 35-90 ng/mL. Plasma TFPI levels were still about 2-fold above basal levels at 12 h and fell to basal levels at 16 h after tinzaparin dose. Basal plasma levels of NO, but not TFPI, were significantly lower ( ...
p,A sustained release system for interleukin-2 (IL-2), and IL-2 mini-pellet (IL-2 mp), was developed by fusing IL-2 into a needle shaped collagen. Serum concentration of IL-2 after a single subcutaneous injection of the IL-2 mp into C57BL/6 mice remained elevated longer than after an injection of aqueous IL-2. IL-2 in the serum became undetectable by 6h after a subcutaneous injection of 1 x 10(6) unit of IL-2 in phosphate-buffered saline (PBS). In contrast, after a single subcutaneous injection of IL-2 mp containing the same amount of IL-2, the concentration of IL-2 increased to its maximum at 6h after injection, then began to decrease gradually. IL-2 was detected even on the third day after a single subcutaneous injection of one IL-2 mp. Augmentation of NK activity and generation of IL-2 activated killer cells were observed in the spleen from day 1--day 3 after a single subcutaneous injection of IL-2 mp into C57BL/6 mice. This activation was not observed following a single subcutaneous ...
Jolly, H., Simpson, K., Bishop, B., Hunter, H., Newell, C., Denney, D. and Oleen-Burkey, M. (2008) Impact of warm compresses on local injection-site reactions with self-administered glatiramer acetate. Journal of Neuroscience Nursing. 40(4), p.232-239.. Abstract:. Patients with multiple sclerosis (MS) report a number of adverse events related to immunomodulator injections, including local injection-site reactions (LISRs). Reactions characterized by pain, swelling, redness, or inflammation have been experienced by patients who self-inject glatiramer acetate, interferon beta-1b, or interferon beta-1a. Although these reactions rarely are serious, they can foster negative attitudes about self-injection and undermine a patients commitment to treatment, especially in the early stages of therapy. This randomized crossover study of 50 patients who had initiated or restarted glatiramer acetate therapy within the 3 months before the study examined whether applying a warm compress to the injection site ...
Pioneering digital solutions, for people with diabetes taking insulin, are to be brought to market as two top companies have announced a major collaboration.. Medtronic, the worlds largest medical device company, headquartered in Dubli, Ireland, has teamed up with Danish pharmaceutical giant Novo Nordisk and together they have pledged to make diabetes management easier by integrating key health technologies.. The partnership intends to develop solutions which will combine insulin dosing data from future Novo Nordisk smart insulin pens into Medtronics Continuous Glucose Monitoring (CGM) devices, such as the Guardian™ Connect system.. This new approach will mean healthcare professionals, caregivers and people with diabetes can automatically track blood glucose levels and insulin dosing, making the whole process a lot easier for all those involved, particularly for people with the condition.. It is hoped that these developments will save time for people with diabetes every day, as well as ...
Participants from the Base Trial P05787 who received a single subcutaneous (SC) injection of 150 µg Corifollitropin Alfa on day 2 or 3 of the menstrual cycle (Stimulation Day 1); 7 daily SC injections from Stimulation Days 1 to 7 with placebo-recombinant Follicle Stimulating Hormone (recFSH); followed by daily SC injections with 200 IU recFSH up to the day of human chorionogonadotropin (hCG); multiple daily SC injections of Ganirelix from Stimulation Day 5 to the day of hCG; a single dose of hCG (5000 or 10,000 IU/USP) was administered when 3 follicles ,= 17 mm were observed; and on the day of oocyte pick up (OPU) daily doses of progesterone were started and continued for up to 6 weeks or menses. Eligible participants from the Base Trial were enrolled in Follow Up Trial P05712, where no study treatments were given, and pregnancy, delivery and neonatal outcome were monitored ...
To complete your registration, we ask you take a moment to read the below information to better understand how Novo Nordisk uses the information you provided us. When you finish reading, please check the I Agree box and confirm your age. Then click SUBMIT to complete your registration.. Novo Nordisk respects the importance of your privacy and understands your health is a very personal and sensitive subject. Novo Nordisk wants you to understand how it will use the information provided by you on this registration page. By clicking I Agree below, you are indicating you want to learn more about this service and receive promotional or non-promotional updates via email or mail from Novo Nordisk or its partners about products, support services, or other special opportunities that Novo Nordisk or its partners believe might be interesting to you. You also understand that you may opt out from receiving any future communications from Novo Nordisk or its partners by clicking the unsubscribe link ...
At Novo Nordisk, we embrace different perspectives and ways of thinking to help us best serve our patients. Learn more about our Diversity and Inclusion initiatives.
To the Editor:. We read with interest the article by Reggia, et al1, a monocentric study analyzing the efficacy and safety of switching from intravenous (IV) to subcutaneous (SC) formulation of abatacept (ABA) in patients with rheumatoid arthritis. The authors report a relatively high risk of disease relapse (27%) occurring in a mean of 11 weeks after switching to SC administration. The study did not find any significant predictive factor for a switch failure. The concern that patients with a higher body mass index could receive lower cumulative doses compared to weight-tiered monthly infusions, leading to a significant influence on treatment efficacy, was not confirmed by this study, or by previous dose-finding trials and non-inferiority randomized studies2,3,4.. We describe our experience based on a case series of 21 consecutive patients switching from ABA IV to SC administration at our center. The switch was motivated by difficulties in obtaining peripheral venous access, or to optimize ...
Subcutaneous Delivery of Daratumumab Is Safe, Effective in Multiple Myeloma - ASH Annual Meeting, On Location - ASH Clinical News
Novo Nordisk markets obesity drug Saxenda, which initially gained approval in the U.S. in 2014. Things are looking up for the drug, with sales more than doubling in the first quarter of 2017 compared with the prior-year period. Novo Nordisk also recently won FDA approval for a label update showing long-term safety and efficacy data for Saxenda.. One major advantage that Novo Nordisk has is that Saxenda fits well with the companys strong diabetes product lineup, since many patients with diabetes also battle obesity. Novo Nordisk continues to be a leader in the diabetes market with its insulin products and Victoza generating solid growth.. Expect the company to maintain its diabetes leadership with promising new drugs such as semaglutide, which could gain FDA approval later this year. Novo Nordisk also is expanding its presence in hemophilia. The company has several hemophilia drugs on the market and awaits approval for hemophilia B drug N9-GP. ...
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Il manuale duso Novo Nordisk 30G disponibile per la visualizzazione in linea, così come per il download in formato PDF - la possibilità di stampare e leggere offline.
This study was undertaken to characterize the toxicokinetics of p-tert-octylphenol (OP), a weak estrogenic compound, in male and female rats. Male and female Sprague-Dawley rats were given a single dose of OP either by oral gavage (50, 125 or 250 mg/kg), by intravenous (iv) injection (2, 4, or 8 mg/kg), or by subcutaneous (sc) injection (125 mg/kg). In a repeated dosing experiment, rats were given OP (oral) daily (25, 50, or 125 mg/kg) for 35 d (female) or 60 d (male). Blood and tissue samples were collected and analyzed for OP content using gas chromatography with detection by mass spectrometry. Blood OP concentrations were generally higher in female than male rats following a single oral or sc administration but were similar following a single iv injection. Tissue OP concentrations were also higher in female than male rats following oral exposure, consistent with the faster metabolism of OP observed in male rat liver microsomes. After subchronic administration, blood OP concentrations were higher at
Novo Nordisk A/S: Switching to Once-Daily Victoza(R) (Liraglutide [rDNA Origin] Injection) from Exenatide Further Improves Blood Sugar Control in Patients with Type 2 Diabetes - read this article along with other careers information, tips and advice on BioSpace
Novo Nordisk has initiated its first Phase I trial with an oral insulin analogue, called NN1952, which it hopes could one day provide an alternative to daily injections for diabeties patients. - News - PharmaTimes
Heres the bottom line: people are dying because the price of insulin is increasing every single month. Since 2014, the price of insulin has increased by a shocking 64%. Who is one of the the worst offenders? Novo Nordisk, a global healthcare company that increased the price of its insulin by 6% over the course of just two months this year. This just after it promised to cap annual price increases
Therapy areas that Novo Nordisk are involved in for their patients including diabetes care, haemophilia and bleeding disorders, growth hormone therapy and hormone replacement therapy.
Discover why Novo Nordisk is conducting and commissioning research that helps describe and measure the challenges people living with diabetes face on a daily basis.
Novo Nordisk, a world leader in diabetes care, today announced the re-launch of Cornerstones4Care, an award-winning online patient support platform for people living with diabetes.
Caught by an outcry over high insulin prices, Eli Lilly has unveiled an authorized generic version of its Humalog insulin. But the other two major providers, Sanofi and Novo Nordisk, dont seem to have any plans to follow suit in the near term.
A Novo Nordisk drug candidate for type 2 diabetes beat Eli Lillys dulaglutide (Trulicity) in reducing blood sugar and body weight in patients studied in a
A Novo Nordisk drug candidate for type 2 diabetes beat Eli Lillys dulaglutide (Trulicity) in reducing blood sugar and body weight in patients studied in a
Shop Novo Nordisk Levemir innolet 100iu/ml 3ml 5 pack online from Healthcare products collection at Mistrys pharmacy. Visit our online store today!
Novo Nordisk has announced that it will team up with IBM to use the firms Watson computing system in diabetes research.  - News - PharmaTimes
BAGSVÆRD, Danmark, March 28, 2014 /PRNewswire/ -- Novo Nordisk lancerer nyt initiativ til at bekæmpe diabetes i verdens storbyer.
Novo Nordisk Foundation Center for Basic Metabolic Research. University of Copenhagen. The University of Copenhagen seeks a highly motivated and talented postdoctoral fellow to commence October 1, 2020 at the Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen.. The postdoctoral fellowship is part of the Novo Nordisk Foundation Center for Basic Metabolic Research International Postdoctoral Program www.cbmr.ku.dk/postdocprogram.. About Us. The Novo Nordisk Foundation Center for Basic Metabolic Researchs vision is to strengthen interdisciplinary research that transforms our basic understanding of the mechanisms that underlie metabolic health and disease, and to accelerate this knowledge toward new prevention and treatment strategies. We were established in 2010, and in 2017 we moved into new laboratories, offices and meeting rooms in the Maersk Tower www.maersktower.ku.dk.. The Center has around 200 employees who work in an international, highly collaborative ...
This material is intended for global medical media only. For journalistic assessment and preparation before publication. Novo Nordisk announced today that data
Fieldpoint Private Securities LLC boosted its position in shares of Novo Nordisk A/S (NYSE:NVO) by 285.8% during the 3rd quarter, according to the company in its most recent filing with the SEC. The institutional investor owned 7,715 shares of the companys stock after purchasing an additional 5,715 shares during the period. Fieldpoint Private Securities LLCs […]
Research outputs, collaborations and relationships for Novo Nordisk A/S published between 1 May 2019 - 30 April 2020 as tracked by the Nature Index.
Novo Nordisk CEO Lars Rebien Sørensenoffers his view on why our Triple Bottom Line (TBL) is fundamental to the waywe manage our business. Also, meet three...
We offer global graduate jobs within 10 different programmes for candidates with a masters degree from 2016 or 2017. Read more and apply between 20 January...
Bagsværd, Denmark, 20 March 2017 - On 2 February 2017, Novo Nordisk initiated a share repurchase programme in accordance with Article 5 of Regulation No. 596/2014 of the European Parliament and Council ...
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MINNEAPOLIS--(BUSINESS WIRE)-- DiaMedica Therapeutics Inc. (Nasdaq: DMAC), a clinical-stage biopharmaceutical company focused on developing novel treatments for kidney diseases and neurological disorders, today provided a business update and reported its financial results for the three and nine months ended September 30, 2019. Clinical Developments DM199 for the Treatment of Chronic Kidney Disease Phase Ib Clinical Study in Patients with CKD Completed DiaMedica has completed its Phase Ib clinical trial of DM199, a recombinant form of the endogenous human tissue kallikrein protein (KLK1), in patients with moderate or severe Chronic Kidney Disease (CKD) caused by Type I or Type II diabetes mellitus. The study was performed to assess the pharmacokinetics (PK) of three dose levels of DM199 (3, 5 and 8 µg/kg), administered in a single subcutaneous dose, as well as the evaluation of safety, tolerability and secondary pharmacodynamic (PD) endpoints. The Company previously announced positive interim ...
I have seen the SC heparin syringes being used to administer IM injections in very thin patients. I understand they are thin and using a normal size IM needle will hit bone and is unncessary. However
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Indications for Drugs ::. To prevent Hepatiis B virus. Drug Dose ::. Adult: IM Basic course consists of 3(1 ml each) doses: 2nd and 3rd doses given 1 and 6 mth after the 1st dose respectively. More rapid immunization 3rd dose can be given 2 months after initial dose with booster at 12 months.Dose depends on the product used. Typical doses: 10 or 20 mcg. Given via SC administration in haemophiliacs. Child: 0.5 ml each 3 doses should be injected as same manner as adult.. Contraindication ::. Previous confirmed anaphylactic reaction to a previous dose of a vaccine containing the same antigens. Hypersensitivity. Vaccines prepared in egg cultures are contraindicated in patients with hypersensitivity reactions to egg. Severe immunodeficiency. Malignant disease being treated with chemotherapy or radiotherapy and for at least 6 mth after stopping treatment. Patients with compromised immune system such as those on high-dose systemic corticosteroids, immunosuppressants or HIV positive.. Drug Precautions ...
Looking for online definition of injection-site reactions in the Medical Dictionary? injection-site reactions explanation free. What is injection-site reactions? Meaning of injection-site reactions medical term. What does injection-site reactions mean?
The report on the Global Insulin Pen Needles market offers complete data on the Insulin Pen Needles market. Components, for example, main players, analysis, size, situation of the business, SWOT analysis, and best patterns in the market are included in the report. In addition to this, the report sports numbers, tables, and charts that offer a clear viewpoint of the Insulin Pen Needles market. The top contenders BD, Novo Nordisk, Artsana, B. Braun, Terumo, Ypsomed, Owen Mumford, HTL-Strefa, Beipu, Kangdelai, Ulticare, Allison Medical, Dongbao of the global Insulin Pen Needles market are further covered in the report .. Access to the sample pages of the report at: http://www.extentresearch.com/request-for-sample.html?repid=20302. The report also segments the global Insulin Pen Needles market based on product mode and segmentation Standard Insulin Pen Needles, Safety Insulin Pen Needles. The study includes a profound summary of the key sectors and the segments Home Use, Medical Institutions, Others ...
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Background and Objectives: Nitric oxide (NO) is a major endothelium dependent vasomediator and growth inhibitor. NO synthesis is catalyzed by endothelial nitric oxide synthase (eNOS), and NO can also produce peroxynitrite, which activates matrix metalloproteinases (MMPs). The purpose of this study was to determine the gene expression of eNOS and MMP-2 in the lungs of a rat model of pulmonary hypertension after bosentan treatment. Materials and Methods: Six-week-old male Sprague-Dawley rats were treated as follows: control group, subcutaneous (sc) injection of saline; monocrotaline (MCT) group, sc injection of MCT (60 mg/kg); and bosentan group, sc injection of MCT (60 mg/kg) plus 20 mg/day bosentan orally. The rats were sacrificed after 1, 5, 7, 14 and 28 days. Results: The right ventricle/(left ventricle+septum) ratio significantly increased in the MCT group compared to the control group on day 14 and 28. The expression of eNOS messenger ribonucleic acid was significantly increased in the MCT ...
Objective: To observe the efficacy and safety between Pegfilgrastim (PEG-rhG-CSF) and Recombinant human granulocyte colony stimulating factor (rhG-CSF) in hematological malignancy after allogeneic hematopoietic stem cell transplantation (allo-HSCT) . Methods: 157 patients after allo-HSCT were enrolled in this study from June 2015 to November 2016. Two agents of G-CSF were used to stimulate hematopoietic recovery after transplantation. There were 65 cases in PEG-rhG-CSF and 92 cases in rhG-CSF groups. Patients in PEG-rhG-CSF group were given a single subcutaneous dose of 6 mg on the first day and +8 d, while cases in rhG-CSF group were given in dose of 5 μg·kg(-1)·d(-1) by subcutaneous injection from +1 d continuing to neutrophils more than 1 ...
LISBON, Portugal-Drugmaker after drugmaker has touted data showing next-gen diabetes meds lower hypoglycemia risks-and new studies from Novo Nordisk show why. Type 2 diabetes patients who suffer severe hypoglycemia are four times more likely to die within 15 days-and twice as likely to die, period.
PLAINSBORO, N.J., Nov. 21, 2016 /PRNewswire/ - Novo Nordisk, a world leader in diabetes care, today announced that the U.S. Food and Drug Administration (FDA) approved the New Drug Application for Xultophy®100/3.6 (insulin degludec 100 units/mL and liraglutide 3.6 mg/mL injection). Xultophy® 100/3.6 is a once-daily, combination of Tresiba® (insulin degludec …. ...
Novo Nordisk, a global leader in diabetes care, today announced that data from 60 abstracts will be shared at the upcoming 77 th annual Scientific Sessions of the American Diabetes
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Oxford University and Novo Nordisk announced the expansion of their international fellowship programme to support research within the fields of diabetes and metabolism.
Former Champions, Elites Return To Compete In The 2014 Novo Nordisk New Jersey Marathon April 27. Three-Time Mens Winner Oz Pearlman, 2011 Womens Champ Bronawyn OLeary, 13 Half Winner Erin Reddan Among Top Competitors Committing To Field - PR12289157
Promising results of a phase I study suggest that single-dose recombinant human interleukin 12 (rhIL-12) may have therapeutic benefits in HIV-positive patients. Dr Mark A. Jacobson of the University of California at San Francisco and multicenter colleagues examined the effects of a single subcutaneous dose of rhIL-12 in a dose-escalation study. They randomized 47 patients with CD4+ T lymphocyte counts between 100 and 500 cells/µL to doses ranging from 3 ng/mg to 1000 ng/mg or to placebo.. At doses greater than 30 ng/mg, patients demonstrated increases in absolute numbers of CD8+ T lymphocyte cells and natural killer (NK) cells, suggesting an augmentation of HIV-specific immunity. Treatment with rhIL-12 also induced a rise in serum interferon-gamma levels, consistent with earlier studies of the cytokine in both animals and humans. Of interest, rhIL-12 administration to HIV-positive patients did not change their absolute CD4+ T cell counts or the amount of circulating plasma HIV RNA, Dr ...
This study investigated the effect of bortezomib administered once a week via subcutaneous route in patients with AL Amyloidosis.
BioAssay record AID 130353 submitted by ChEMBL: In vivo antinociceptive activity was determined using mouse acetylcholine induced abdominal constriction test following subcutaneous administration; range (0.23-0.70).
Human Data: The results from a population-based prospective cohort, including 70 women exposed to morphine during the first trimester of pregnancy and 448 women exposed to morphine at any time during pregnancy, indicate no increased risk for congenital malformations. However, these studies cannot definitely establish the absence of any risk because of methodological limitations, including small sample size and non-randomized study design.. Animal Data: Formal reproductive and developmental toxicology studies for morphine have not been conducted. Exposure margins for the following published study reports are based on human daily dose of 60 mg morphine using a body surface area comparison (HDD).. Neural tube defects (exencephaly and cranioschisis) were noted following subcutaneous administration of morphine sulfate (35 to 322 mg/kg) on Gestation Day 8 to pregnant hamsters (4.7 to 43.5 times the HDD). A no adverse effect level was not defined in this study and the findings cannot be clearly ...
TY - JOUR. T1 - Efficacy and safety of once-Weekly semaglutide versus exenatide ER in subjects with type 2 diabetes (SUSTAIN 3). T2 - A 56-Week, open-Label, randomized clinical trial. AU - Ahmann, Andrew J.. AU - Capehorn, Matthew. AU - Charpentier, Guillaume. AU - Dotta, Francesco. AU - Henkel, Elena. AU - Lingvay, Ildiko. AU - Holst, Anders G.. AU - Annett, Miriam P.. AU - Aroda, Vanita R.. N1 - Funding Information: participants, investigators, and trial-site staff who were involved in the conduct of the trial. The authors also thank Denise Chang, PhD (the original trial statistician), and Desirée Thielke, MD, and Uffe Jon Ploug, MSc (both of Novo Nordisk), for their review of and input to the manuscript; and Alex Coulthard and Nicole Antonio, PhD (both of AXON Communications), for medical writing and editorial assistance (both received compensation from Novo Nordisk). Funding. This study was supported by Novo Nordisk A/S. Funding Information: The funder contributed to the design and conduct ...
Net profit increased by 9% to DKK 37.9 billion. Diluted earnings per share increased by 11% to DKK 14.96. Adjusted for the partial divestment of NNIT, net profit and diluted earnings per share increased by 17% and 19%, respectively.. In November 2016, Novo Nordisk announced that Tresiba® demonstrated a safe cardiovascular profile and a statistically significant 40% reduced risk of severe hypoglycaemia compared to insulin glargine U100 in the DEVOTE trial. Also in November 2016, Novo Nordisk received the FDA approval of Xultophy® 100/3.6, the once-daily combination of insulin degludec (Tresiba®) and liraglutide (Victoza®). In January 2017, Novo Nordisk received EU approval of Fiasp®, the new-generation fast-acting insulin. On 1 January 2017, Lars Fruergaard Jørgensen replaced Lars Rebien Sørensen as president and CEO, who retired after 34 years of loyal service with the company, the last 16 years as CEO. For 2017, reported sales growth is expected to be 1-6% measured in Danish kroner, ...
Efficacy and Safety Study of Diclofenac HPBCD 25, 50 mg/ml Administered as Single s.c. Dose, in the Treatment of Acute Moderate-to-severe Post-surgical Pain From Dental Surgery (Impacted 3rd Molar Extraction ...
Injectable biologics target specific parts of the immune system, making them popular treatment options for psoriasis patients, with ample research on their efficacy. Performing a self-injection can be daunting for patients trying a biologic for the first time, and clinicians should be aware of the dearth of patient education material. Although patients may be fearful of self-injections, especially the first few treatments, their worries can be assuaged with proper instruction and appropriate delivery method.. Abrouk et al sought to provide an online guide and video on biologic injections to increase the success of the therapy and compliance among patients. They created a printable guide that covers the supplies needed, procedure techniques, and plans for traveling with medications. Because pain is a common concern for patients, they suggest numbing the injection area with an ice pack first. They also offer tips on dealing with injection-site reactions such as redness or bruising.. Nurse ...
Definition of insulin injection site in the Financial Dictionary - by Free online English dictionary and encyclopedia. What is insulin injection site? Meaning of insulin injection site as a finance term. What does insulin injection site mean in finance?
Three patients enrolled in this study had non-follicular lymphoma histologies. One with small lymphocytic lymphoma achieved a complete response, currently ongoing now 72 weeks after treatment. The other 2 patients (one SLL, one MZL) entered with high levels of circulating B cells and failed to achieve an objective response. We have reported that in patients with chronic lymphocytic leukemia (CLL), the same subcutaneous doses and dosing schedule of veltuzumab used here also failed to achieve meaningful clinical benefit, but had evidence of pharmacological activity with transient decreases in the high levels of circulating leukemic B cells.32 For subcutaneous injections, more frequent or extended dosing or combination therapy with other agents will likely be required to overcome the higher antigen burden in these settings, consistent with the experience of other anti-CD20 antibodies which are given intravenously at much higher doses for patients with chronic lymphocytic leukemia.21. Compared to ...
This medicine may cause a serious allergic reaction, including anaphylaxis, which can be life-threatening and requires immediate medical attention. Tell your doctor right away if you have a rash, itching, shortness of breath, swelling of the face, tongue, and throat, trouble breathing, or chest pain after you receive the medicine. You may have some skin redness, rash, itching, or swelling at the injection site. If this irritation is severe or does not go away, call your doctor. Do not inject insulin lispro into a skin area that is red, swollen, or itchy. Using this medicine together with other diabetes medicine (eg, pioglitazone, rosiglitazone, Actos®, Actoplus Met®, Avandia®) may cause serious heart problem or edema (fluid retention). Check with your doctor immediately if you are rapidly gaining weight, having shortness of breath, chest pain or discomfort, extreme tiredness or weakness, trouble breathing, uneven heartbeat, or excessive swelling of the hands, wrist, ankles, or feet. Too much ...
The adverse effects of warfarin are deadly or non lethal bleeding, nausea, vomiting, diarrhoea, alopecia, fever, hypersensitivity response, an overdose is viewed by bleeding within the gums and haematuria, in rare circumstances pores and skin necrosis is usually witnessed. A number of the nursing details and safeguards with warfarin are, that all intramuscular injections be avoided, and subcutaneous injection sites needs to be closely monitored for haematoma, make sure that the does is provided the exact same time day by day to Mr ...
Haspedis L. Terbutaline in the treatment of preterm labor: a comparison of intravenous and subcutaneous administration. J Am Osteopath Assoc 1988;88(4):489. doi: https://doi.org/10.7556/jaoa.1988.88.4.489.. Download citation file:. ...
BioAssay record AID 177298 submitted by ChEMBL: Effect of compound on 5-Hydroxy transaminase accumulation upon subcutaneous administration in the limbic system of rat brain.
Results Most patients showed good clinical responses after low-dose IL-2 treatment (7 out of 9). Clinical improvement was observed with SIR-4 response (6 out of 9), improved complement 3 and 4 serum level (9 out of 9) and decreased anti-ds-DNA serum level (8 out of 9). Functional profiling of CD8 T cells in low-dose IL-2 treated patients revealed increased frequencies of CEF viral peptide specific TNF-a+ and Granzyme-B+ CD8 T cells. Moreover, these patients showed stronger antigen-specific response demonstrated by an increased stimulated/non-stimulate TNF-a-producing CD8 T cells proliferation fold. Compared with HC, SLE patients showed significantly lower frequencies of CEF specific Granzyme-B producing CD8 T cell, and low-dose IL-2 significantly increased the frequency of these Granzyme-B+ CD8 T cells in SLE patients. ...
Results Of 1372 pts entering the LTE, 1134 (82.7%) remained on therapy at time of reporting. Mean baseline RA duration was 8 yrs, TJC and SJC were 30 and 20, respectively, and HAQ-DI was 1.7. Median (range) ABA exposure was 33 (8-44) mths. The incidence rate (IR; events/100 pt-yrs) of serious adverse events for pts treated with SC ABA in the LTE (8.76 [95% CI: 7.71-9.95]) was comparable with that for SC ABA in the DB period (9.02 [6.31-12.90]) and did not increase with increasing exposure. The IR of overall and serious infections in the LTE (44.80 [41.81-48.01] and 1.72 [1.30-2.27], respectively) did not increase vs the DB period (84.62 [74.50-96.11] and 1.48 [0.62-3.56], respectively). Bacterial, viral and hospitalised infections occurred at IRs of 27.28 (25.16-29.57), 18.25 (16.61-20.06) and 1.55 (1.16-2.07) during the LTE. The IR of malignancy did not increase in the LTE (1.19 [0.86-1.66]) vs the DB period (0.59 [0.15-2.36]). Injection-site reactions occurred in 27 (2.0%) pts in the LTE (none ...
Breast-feeding There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding. Other medicines Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine. Other interactions Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco. Other medical problems The ...
This medicine should come with a Medication Guide. Read and follow these instructions carefully. Ask your doctor if you have any questions. You will be using pramlintide at home. Your doctor will teach you how the injections are to be given. Be sure you understand exactly how the medicine is to be injected. Tell your doctor if you have dexterity (skill in using the hands) or vision problems. This medicine is given as a shot under the skin of your stomach or upper thigh. Inject pramlintide at a site that is more than 2 inches away from your insulin injection. Never inject insulin and pramlintide in the same site. When you first start using this medicine, you will need to adjust your insulin dose. Do not change the timing or amount of any of your medicines without your doctors advice. It is very important that you follow your doctors instructions about all medicines you use to control your diabetes. You should never mix your insulin and pramlintide injections together. These injections are ...
Given as subcutaneous injections. Side effects include fatigue and influenza-like symptoms Cladribine (CdA). Chemotherapy which ... is given as subcutaneous injections. Side effects include immunodeficiency and infections. Tyrosine kinase inhibitors (TKI) ...
... is administered by subcutaneous injection.[3][5] For most indications, the maintenance treatment is an injection ... Furthermore, adalimumab was safe and effective when given alone or in combination with MTX as a subcutaneous injection.[47] ... Common side effects include upper respiratory tract infections, pain at the site of injection, rash, and headache.[5] Other ... "Humira 40 mg solution for injection in pre-filled syringe - Summary of Product Characteristics (SmPC)". (emc). 27 November 2019 ...
Durham H. E., Br Med J. 1904 Feb 27;1(2252):480-2. On subcutaneous injections of adrenalin. Elliott TR, Durham H. E., J. ...
"Nplate (romiplostim) for subcutaneous injection". www.fda.gov. Retrieved 2015-05-02. Warkentin, Theodore E.; Greinacher, ...
... taken by an injection into the fat below the skin. Sometimes referred as subcutaneous injections. Some of these medications ...
The etanercept group received subcutaneous injections of the drug twice weekly for 12 weeks while the ustekinumab group ... "Repeated subcutaneous injections of IL12/23 p40 neutralising antibody, ustekinumab, in patients with relapsing-remitting ... Clinical trials have shown that subcutaneous ustekinumab was generally well tolerated. Most treatment-emergent adverse events ... received two injections, one month apart, of either 90 or 45 milligrams. At twelve weeks, psoriatic plaques were reduced by at ...
... is available as a single-use, pre-filled syringe and is administered via subcutaneous injection. The recommended ... Tildrakizumab is administered via subcutaneous injection. It is available as a single-dose prefilled syringe containing 100 mg ...
... is administered by subcutaneous injection; each dose is effective for four to eight weeks. The United States ...
GENERAL ANÆSTHESIA BY SUBCUTANEOUS INJECTIONS". American Journal of Physiology. Legacy Content. 14 (4): 366-388 Auer, J. SOME ... General Anæsthesia by Subcutaneous Injections". American Journal of Physiology. Legacy Content. 14 (4): 366-388. doi:10.1152/ ... They found that injection of the compound would result in a loss of consciousness and total muscle relaxation. Coupled with the ...
Dalteparin - Subcutaneous Injection, HealthLinkBC , https://www.healthlinkbc.ca/medications/fdb0271 Pfizer Medical Information ... In May 2019, the U.S. Food and Drug Administration (FDA) approved Fragmin injection to reduce the recurrence of symptomatic VTE ... It is normally administered by self-injection. The CLOT study, published in 2003, showed that in patients with malignancy and ...
"Kynamro (mipomersen sodium) Injection, Solution for Subcutaneous Injection. Full Prescribing Information" (PDF). Kastle ... After subcutaneous injection, mipomersen reaches highest blood levels after 3 to 4 hours. It accumulates in the liver,[citation ... is used to treat homozygous familial hypercholesterolemia and is administered by subcutaneous injection. There is a serious ... Kynamro is used to treat homozygous familial hypercholesterolemia and is administered by injection. It cannot be freely ...
The most commonly tested methods are subcutaneous and intravenous injections of mice. Subcutaneous is the most applicable to ... by subcutaneous injection. According to Brown (1973), the subcutaneous LD50 value is 0.4 mg/kg, while Ernst and Zug et al. list ... 1996 and the Australian venom and toxin database both list a LD50 value of 0.106 mg/kg for subcutaneous injection. Engelmann ... The subcutaneous LD50 for the venom of this species is 0.4 mg/kg. For comparison, the Indian cobra's (naja naja) subcutaneous ...
... oil solutions for intramuscular injection; and aqueous solutions for subcutaneous injection. A 1% topical progesterone gel is ... oil solutions for intramuscular injection, and aqueous solutions for subcutaneous injection. Routes of administration that ... An aqueous solution of progesterone complexed with β-cyclodextrin for subcutaneous injection is marketed under the brand name ... Intramuscular injection may cause mild-to-moderate pain at the site of injection. High intramuscular doses of progesterone have ...
... injection, also known as classical "intradermal" injection), fat ("subcutaneous" injection), or muscle ("intramuscular" ... "Needle Free Jet Injection System - Needle Free Injection System". Needle Free Injection System. Retrieved 2018-05-25.. ... It is claimed by its manufacturer that it can deliver intramuscular injections and subcutaneous injections up to 1 milliliter. ... "Virus Transmission by Subcutaneous Jet Injection". J Med Microbiol. 20 (3): 393-7. doi:10.1099/00222615-20-3-393. PMID 4068027. ...
Dale's report of subcutaneous injections contradicts the concerned parties. Oliver: "During the winter of 1893-4, while ... Intravenous injection of pilocarpine to induce bronchospasm was followed by intravenous injection of the agonists. "Arrangement ... The surgeon Heinrich Braun in Leipzig showed that it prolonged the anesthesia at the injection site and simultaneously reduced ... So Professor Schafer makes the injection, expecting a triumphant demonstration of nothing, and finds himself standing ′like ...
Deferoxamine is administered via intravenous, intramuscular, or subcutaneous injections. Oral administration is not possible as ... Ambruso, DR; Mahony, BS; Githens, JH; Rhoades, ED (1982). "Effect of subcutaneous deferoxamine and oral vitamin C on iron ... and so does not require intravenous or subcutaneous administration. With a terminal elimination half life of 8-16 hours, the ...
It is administered by subcutaneous injection. It is a mixture of random-sized peptides that are composed of the four amino ... Side effects may include a lump at the injection site (injection site reaction) in approximately 30% of users, and aches, fever ... Over time, a visible dent at a repeat-injection site can occur due to the local destruction of fat tissue, known as lipoatrophy ... "Glatopa- glatiramer acetate injection, solution". DailyMed. 31 July 2020. Retrieved 11 November 2020. "Brabio 20 mg/mL Solution ...
... is administered by subcutaneous injection. For most indications, the maintenance treatment is an injection every ... Furthermore, adalimumab was safe and effective when given alone or in combination with MTX as a subcutaneous injection. 2002, ... "Imraldi- adalimumab injection, solution". DailyMed. 23 January 2018. Retrieved 18 February 2020. Navarro-Sarabia F, Ariza-Ariza ... It is administered by injection under the skin. Common side effects include upper respiratory tract infections, pain at the ...
It is administered by subcutaneous injection. Common side effects are constipation, pruritus, muscle spasms, as well as mild ... After subcutaneous injection, the erenumab has an estimated bioavailability of 82%. Highest blood plasma concentrations are ... and mostly transient reactions at the injection site. Erenumab was shown not to interact with ethinyl estradiol, norgestimate ...
It is administered by subcutaneous injection. As of July 2015, it is not known whether alirocumab prevents early death from ... After subcutaneous administration of alirocumab, maximal suppression of free PCSK9 occurs within 4 to 8 hours and has an ... "Praluent- alirocumab injection, solution". DailyMed. Retrieved 1 April 2021. "Therapy for patients with severely high ... Common side effects include nasopharyngitis (cold), injection site reactions, and influenza. It was approved for medical use in ...
The most commonly prescribed methods are intramuscular and subcutaneous injections. This dosing can be weekly or biweekly ... Treatment options include oral, parenteral, subcutaneous implant, and transdermal (patches, gels). Dosing is patient-specific ...
He had been using subcutaneous injections of creosote for tuberculosis. In 1894 he administered subcutaneous injection of ... Given by injection the drug caused fever and other local reactions. Despite these difficulties, a series of 170 patients were ... They were given by injection and orally, and were believed to cure some people, but results were often disputed. It was not ... Heiser and Mercado in 1913 administered the oil by injection to two patients, with the result that they were cured of the ...
Reconstitution in sterile diluent produces a solution for subcutaneous injection. As with HIV, the development of an effective ...
Subcutaneous injections have better evidence than under the tongue dosing. Topical steroids as nasal spray or inhalation may be ...
The bioavailability of bremelanotide with subcutaneous injection is about 100%. Following a subcutaneous injection of ... It is given by an injection just under the skin of the thigh or abdomen. Common side effects include nausea, pain at the site ... The drug was then reformulated to be delivered by injection and trials continued in FSD. A phase II dose-finding trial in FSD ... Other side effects may include flushing (20.3%), injection site reactions (13.2%), headache (11.3%), vomiting (4.8%), cough ( ...
It is administered by intermittent injections or continuous subcutaneous infusions. Since secondary effects such as confusion ... When oral medications are not enough to control symptoms, surgery, deep brain stimulation, subcutaneous waking day apomorphine ...
... subcutaneous). Subcutaneous immunotherapy is the most common form and has the largest body of evidence supporting its ... The allergen can be given as an injection under the skin or as a tablet under the tongue. Treatment typically lasts three to ... Creticos P. "Subcutaneous immunotherapy for allergic disease: Indications and efficacy". UpToDate. Calderon MA, Alves B, ... Immunotherapy can be administered orally (as sublingual tablets or sublingual drops), or by injections under the skin ( ...
"Kineret (anakinra) injection, for subcutaneous use" (PDF). Swedish Orphan Biovitrum. Arend WP, Malyak M, Guthridge CJ, Gabay C ...
Sternberg, George Miller (30 April 1881). "A fatal form of septicaemia in the rabbit produced by the subcutaneous injection of ...
Dermal or subcutaneous fillers are substances injected into the skin to improve the appearance of acne scars. Fillers are used ... Another procedure for immediate relief is the injection of a corticosteroid into an inflamed acne comedo.[77] Electrocautery ... the follicle can break into the deeper layers of the dermis and subcutaneous tissue and cause the formation of deep nodules.[1] ...
... in 2016 it gained EU approval in a formulation for subcutaneous injection for CLL.[48] ... Originally available for intravenous injection (e.g. over 2.5 hrs), ... It is given by slow injection into a vein.[2] ...
The peripheral stem cell yield is boosted with daily subcutaneous injections of Granulocyte-colony stimulating factor, serving ... Coagulation issues and inflammation of atherosclerotic plaques are known to occur as a result of G-CSF injection. G-CSF has ... as a result of filgrastim treatment is observed in 80 percent of donors by day 4 post-injection.[45] This pain responded to ... Side effects included pain prior to the collection procedure as a result of GCSF injections, post-procedural generalized ...
... in 2016 it gained EU approval in a formulation for subcutaneous injection for CLL.[48] ... "EU approves second indication for subcutaneous form of Roche's rituximab". Archived from the original on 2016-06-07. Retrieved ... Originally available for intravenous injection (e.g. over 2.5 hrs), ... It is given by slow injection into a vein.[2] ...
Injection,. infusion. (into tissue/blood). Skin. *Intradermal. *Subcutaneous. *Transdermal implant. Organs. *Intracavernous ...
Duration by intramuscular or subcutaneous injection in oil solution. d = Never marketed. Sources: See individual articles. ...
Injection,. infusion. (into tissue/blood). Skin. *Intradermal. *Subcutaneous. *Transdermal implant. Organs. *Intracavernous ...
... sub cutaneous or intramuscular injections or six-monthly implants. Different formulations of testosterone are used to ensure ... Testosterone gel sachets, Testosterone undecanoate injection (Nebido), Human chorionic gonadotropin (hCG) injection, Menotropin ... Some people with KS/CHH will have their levels checked and may be prescribed extra vitamin D tablets or injections to try to ... Gonadotropin therapy, in the form of human chorionic gonadotropin (hCG) injections, with or without the use of FSH, can also be ...
Drug Information: Pegaptanib Sodium Injection *^ a b c d e "Macugen (pegaptanib)" (PDF). European Medicines Agency: 1-3. 2010. ... Aside from the intravitreal administration of the pegaptanib, it was also found that subcutaneous and intravenous routes of ... Pegaptanib is administered in a 0.3 mg dose once every six weeks by intravitreal injection. An intravitreal injection is one ... Pegaptanib (pegaptanib sodium injection) has been approved in: United States (2004)[6] Europe (2005)[2] Brazil (2005)[6] Canada ...
... by injection into a muscle or under the skin.[1] It may also be administered inside the chest to help prevent the recurrence of ... intravenous, intramuscular, subcutaneous, intrapleural, intratumoral. ATC code. *L01DC01 (WHO) Legal status. Legal status. *US: ... by intramuscular injection, or under the skin.[1] ...
Operations on the skin and subcutaneous tissue 5-93...5-99: additional information on operations 6: Drugs 8: Non-surgical ... therapeutic measures 8-01...8-02: administration of medications and nutritional and therapeutic injection 8-03...8-03: ...
HyQvia had a rate of systemic adverse effects higher than traditional subcutaneous forms of immunoglobulin injection, but lower ... It also increases the absorption rate of parenteral fluids given by hypodermoclysis, and is an adjunct in subcutaneous ... Hyalurodinase is used by plastic surgeons and dermatologists to reverse the effects of hyaluronic acid injections used as ... a form of subcutaneous immunoglobulin (SCIG) that uses Hylenex to allow for a far greater volume of SCIG to be administered ...
... a second fluid injection is sometimes used, a "flush", following the injection to push the medicine into the bloodstream more ... An injection inherently causes pain when the skin is broken and is medically invasive. In cases in which a choice between ... Sometimes injections of hyaluronidase can be used to speed the dispersal of the fluid/drug. Infiltration is one of the most ... Due to frequent injections and recurring phlebitis, scar tissue can build up along the vein. The peripheral veins of ...
Partially digested food starts to arrive in the small intestine as semi-liquid chyme, one hour after it is eaten.[citation needed] The stomach is half empty after an average of 1.2 hours.[31] After four or five hours the stomach has emptied.[32] In the small intestine, the pH becomes crucial; it needs to be finely balanced in order to activate digestive enzymes. The chyme is very acidic, with a low pH, having been released from the stomach and needs to be made much more alkaline. This is achieved in the duodenum by the addition of bile from the gall bladder combined with the bicarbonate secretions from the pancreatic duct and also from secretions of bicarbonate-rich mucus from duodenal glands known as Brunner's glands. The chyme arrives in the intestines having been released from the stomach through the opening of the pyloric sphincter. The resulting alkaline fluid mix neutralises the gastric acid which would damage the lining of the intestine. The mucus component lubricates the walls of the ...
Tomolillo, CM; Crothers, LJ; Aberson, CL (2007). "The damage done: a study of injection drug use, injection related abscesses ... a minimally invasive technique for subcutaneous abscess management in children". Journal of Pediatric Surgery. 45 (3): 606-09. ... Needle exchange programmes often administer or provide referrals for abscess treatment to injection drug users as part of a ... Kraeutler, MJ; Bozzay, JD; Walker, MP; John, K (Oct 24, 2014). "Spinal subdural abscess following epidural steroid injection". ...
Sleeping sickness begins with a tsetse bite leading to an inoculation in the subcutaneous tissue. The infection moves into the ... The name 'mechanical' reflects the similarity of this mode of transmission to mechanical injection with a syringe. Mechanical ...
"Firazyr- icatibant acetate injection, solution". DailyMed. 16 December 2019. Retrieved 17 April 2020.. ... "FDA Approves Shire's FIRAZYR (icatibant injection) for Acute Attacks of Hereditary Angioedema (HAE)" (Press release). Shire. ...
Injection,. infusion. (into tissue/blood). Skin. *Intradermal. *Subcutaneous. *Transdermal implant. Organs. *Intracavernous ...
Photograph showing a subcutaneous neck drain in the left neck wound. A surgical drain is a tube used to remove pus, blood or ...
Subcutaneous injection: the needle is inserted at a 45 degree angle into the (subcutaneous) tissue between the outer layer of ... There are several typical vaccination routes: Intramuscular injection: the needle is inserted perpendicular to the skin into ... the muscle, beneath the skin and (subcutaneous) tissues that rest on top. ...
They are distinct from injection lipolysis, which depends on device-based procedures, while injection lipolysis relies solely ... The degree of exposure to cooling causes cell death of subcutaneous fat tissue, without apparent damage to the overlying skin.[ ... Various lipolysis techniques including injection lipolysis, RF, laser, ultrasound, and cryolipolysis were forbidden in France ... and injection lipolysis and mesotherapy remained illegal. Laser devices that involve inserting the probe through the skin ...
... or by injections under the skin (subcutaneous). ... The allergen may be given as injections just under the skin or ... injection are effective at reducing nasal inflammation,[citation needed] but their use is limited by their short duration of ...
It is administered by intermittent injections or continuous subcutaneous infusions.[74] Since secondary effects such as ... subcutaneous waking day apomorphine infusion and enteral dopa pumps can be of use.[76] The third stage presents many ...
Male mice - injection of a solution of the JQ1 molecule to bind to a pocket of BRDT necessary for chromatin remodeling, which ... The linea alba and then the subcutaneous layer are closed with resorbable suture material. The skin is then stapled, sutured, ... a single injection causes a treated female mammal to produce antibodies that bind to ZP3 on the surface of her ovum, blocking ... "Clinical Evaluation of Non-surgical Sterilization of Male Cats with Single Intra-testicular Injection of Calcium Chloride" ...
"Sodium Chloride Injection - FDA prescribing information, side effects and uses". www.drugs.com. Archived from the original on ... O'Shaugnessy, WB (1831). "Proposal for a new method of treating the blue epidemic cholera by the injection of highly-oxygenated ... By injection into a vein it is used to treat dehydration such as from gastroenteritis and diabetic ketoacidosis.[2] It is also ... are distributed in modern needle-exchange programmes as drugs efficiently can be administered either by injection, or ...
Electrochemotherapy is the combined treatment in which injection of a chemotherapeutic drug is followed by application of high- ... Clinical electrochemotherapy has been successfully used for treatment of cutaneous and subcutaneous tumors irrespective of ... highly effective and safe treatment of cutaneous and subcutaneous metastases". Eur J Cancer Suppl. 4 (11): 3-13. doi:10.1016/j. ... "Electrochemotherapy for cutaneous and subcutaneous tumor lesions: a novel therapeutic approach". Dermatologic Therapy. 23 (6): ...
Intramuscular injection can be complicated in that the depth of subcutaneous fat varies and may result in subcutaneous ... Intramuscular injection does give a faster and higher pharmacokinetic profile when compared to subcutaneous injection.[24] ... by injection into a muscle, by inhalation, or by injection just under the skin.[1] ... When given by the subcutaneous or intramuscular routes for asthma, an appropriate dose is 0.3 to 0.5 mg.[26][27] ...
SUBCUTANEOUS INJECTIONS OF AIR. Br Med J 1907; 2 doi: https://doi.org/10.1136/bmj.2.2447.1559 (Published 23 November 1907) Cite ...
... injection means the injection is given in the fatty tissue, just under the skin. ... Subcutaneous (SQ or Sub-Q) injection means the injection is given in the fatty tissue, just under the skin. ... Change your injection site from one injection to the next, at least 1 inch apart. This will keep your skin healthy and help ... Your injection site should be healthy, meaning there should be no redness, swelling, scarring, or other damage to your skin or ...
It is slower than intramuscular injections but still faster than intradermal injections. A subcutaneous injection is ... Subcutaneous injections are performed by cleaning the area to be injected followed by an injection, usually at an angle to the ... Due to the frequency of injections required for the administration of insulin products via subcutaneous injection, insulin is ... The injection sites for self-injection of medication are the same as for injection by a healthcare professional, and the skill ...
Interferon Beta-1a Subcutaneous Injection: learn about side effects, dosage, special precautions, and more on MedlinePlus ... Interferon beta-1a subcutaneous injection is used to treat adults with various forms of multiple sclerosis (MS; a disease in ... Interferon beta-1a subcutaneous injection comes as a solution (liquid) in a prefilled syringe or a prefilled automatic ... Before you use interferon beta-1a subcutaneous for the first time, your or the person who will be giving the injections should ...
... a subcutaneous injection can be a convenient way of getting a medication into your body. Heres how to administer one. ... Preparing for a subcutaneous injection. The location of injection is important for subcutaneous injections. The drug needs to ... Medications given using a subcutaneous injection. Medications administered by subcutaneous injection include drugs that can be ... can also be given via subcutaneous injection.. Some vaccines and allergy shots are administered as a subcutaneous injection. ...
Subcutaneous). Includes indications, proper use, special instructions, precautions, and possible side effects. ... Easy to read patient leaflet for Methotrexate Injection ( ... Home › Drugs A to Z › Methotrexate Injection (Subcutaneous) › ... Methotrexate Injection (Subcutaneous). Pronunciation. Generic Name: Methotrexate Injection (Subcutaneous) (meth oh TREKS ate). ... Patients with cancer who take methotrexate injection (subcutaneous) may be at a greater risk of getting a bad health problem ...
... www.mayoclinic.org/drugs-supplements/methotrexate-injection-route-subcutaneous-route/precautions/drg-20064776 ... For injection dosage form (solution): * For psoriasis: * Adults-At first, 10 to 25 milligrams (mg) once per week. Your doctor ... Methotrexate injection is used alone or together with other medicines to treat several types of cancer, such as breast, head ... This will help prevent skin problems from the injection. * If the medicine in the syringe has changed color, or if you see ...
Infection at the injection site-The chance of side effects may be increased. ... performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of hyaluronidase injection ... performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of hyaluronidase injection ...
Treatments , Biologics , Subcutaneous Injections. Tips & Resources Last update: 08/29/2012. Overview. * Read and reread the ... Subcutaneous Injections ~ Tips & Resources. Patients and caregivers often need to inject biologics, such as Neupogen and ... Reducing pain: Make sure the injections arent intradermal as these can be painful. Subcutaneous means injected below the skin ... Reducing pain: The key to a comfortable injection is swift needle entry followed by slow injection of fluid. Therefore, slowly ...
Download high-quality Subcutaneous injection into girls face. Doctor images, illustrations and vectors perfectly priced to fit ... Subcutaneous injection into the girls face. Doctor cosmetologist doing pull-injection in the face model. Syringe, face, needle ... one, patient, person, portrait, needle, medical, healthy, injection, isolated, skin, skincare, wellbeing, white, woman, young, ...
... inactivated Subcutaneous, Injection. Includes common brand names, drug descriptions, warnings, side effects and dosing ... Home › Conditions › Typhoid Prophylaxis › typhoid vaccine, inactivated (Subcutaneous route, Injection route) › Advanced Reading ... typhoid vaccine, inactivated (Subcutaneous route, Injection route). TYE-foid VAX-een, in-AK-ti-vay-ted ... pain, redness, or swelling at place of injection. Other side effects not listed may also occur in some patients. If you notice ...
... *Download PDF Copy ... In the multi-center, global HAVEN 3 study, patients aged 12 years and older were given a skin [subcutaneous] injection of new ... The injections were administered weekly in one group, every second week in another group and then the patients number of ... while offering flexible subcutaneous dosing options, says Mahlangu. ...
... subcutaneous granulomas with macrophage-driven translocation of aluminum to regional lymph nodes in sheep. ... A total of 19 subcutaneous injections were performed in a time frame of 15 months. Granulomas and regional lymph nodes were ... All of the vaccine and 92.3% of the adjuvant-only lambs presented injection-site granulomas; the granulomas were more numerous ... They are associated with the appearance of transient injection site nodules corresponding to granulomas. This study aims to ...
Subcutaneous inflammation mimicking metastatic malignancy induced by injection of mistletoe extract BMJ 2006; 333 :1293 doi: ... Subcutaneous inflammation mimicking metastatic malignancy induced by injection of mistletoe extract. BMJ 2006; 333 doi: https ... Gorter RW, van Wiley M, Stoss M, Wollina U. Subcutaneous infiltrates induced by injection of mistletoe extracts (Iscador). Am J ... This was a self administered subcutaneous injection (20 mg three times a week), which she started 12 months before presentation ...
Glucagon (Injection)(Injectable,Subcutaneous) Reviews. 1 people have reviewed this drug. 5* ... Reason for taking Glucagon (Injection)(Injectable,Subcutaneous). Diabetes Mellitus Type II. Diabetes Mellitus Type I. ...
Read our How to Give a Subcutaneous Injection encyclopedia resources online. ... How to Give a Subcutaneous Injection. How to Give a Subcutaneous Injection. ...
Im currently writing a paper on absorption rates of different injections. I was wondering if anyone knows if the patient can ... If an IM injection goes subcutaneous what can happen? allnurses Safe Nurse Staffing T-shirt: Order Today! ... I was wondering if anyone knows if the patient can get an abscess from an IM injection that may have gone subcutaneous? Im ... What do you mean by in but not all the in? Was she hitting bone? Horrible feeling when you are giving the injection to hit ...
Sumatriptan Succinate Subcutaneous Injection, USP) may treat, side effects, dosage, drug interactions, warnings, patient ... After a single 6-mg subcutaneous manual injection into the deltoid area of the arm in 18 healthy males (age: 24 ± 6 years, ... Following a 6-mg subcutaneous injection into the deltoid area of the arm in 9 males (mean age: 33 years, mean weight: 77 kg) ... home drugs a-z list side effects drug center zembrace-symtouch (sumatriptan succinate subcutaneous injection, usp) drug ...
... for Subcutaneous Use) may treat, side effects, dosage, drug interactions, warnings, patient labeling, reviews, and related ... Injections should occur at separate sites in the thigh or abdomen. Rotate injection sites and do not give injections into areas ... Can I pinch or stretch the skin at the injection area?. Yes, pinching or stretching the skin before injection may make the ... Do I need to keep my finger pressed on the injection button for the whole injection? ...
STABLE TESTOSTERONE LEVELS ACHIEVED WITH SUBCUTANEOUS TESTOSTERONE INJECTIONS M.B. Greenspan, C.M. Chang Division of Urology, ... Subcutaneous Testosterone Injections Study STABLE TESTOSTERONE LEVELS ACHIEVED. WITH SUBCUTANEOUS TESTOSTERONE. INJECTIONS. M.B ... AnabolicMinds.com , Forum , Anti-Aging Discussion , Male Anti-Aging Medicine , Subcutaneous Testosterone Injections Study ... Subcutaneous. (SC) testosterone injection is a novel approach; however,. its physiological effects are unclear. We therefore ...
BD is releasing its new Nano pen needle designed for achieving consistent depth during subcutaneous injections, particularly ... BD Unveils Nano Pen Needle for Accurate Subcutaneous Insulin Injections. January 31st, 2019 Medgadget Editors Medicine, ... Intramuscular injections can occur when a patient applies too much force to many of the existing injection devices. The new BD ... BD is releasing its new Nano pen needle designed for achieving consistent depth during subcutaneous injections, particularly ...
Learn more about Subcutaneous Injection at Doctors Hospital of Augusta DefinitionReasons for ProcedurePossible ... Subcutaneous injections are an easy way to deliver this type of medication. Examples of medications given by sub-Q injection ... General Injection Tips. *Change your injection site in a regular pattern.. *Give new injections at least 1.5 inches away from ... A subcutaneous (sub-Q) injection is a shot that delivers medication into the layer of fat between the skin and the muscle. This ...
Aluminium toxicokinetics after intramuscular, subcutaneous, and intravenous injection of Al citrate solution in rats.. Weisser ... Knowledge of dose linearity, plasma clearance, rate and extent of subcutaneous (SC) and intramuscular (IM) absorption of ...
... including injection site pain, injection site erythema and injection site bruising. Of these ISRs, 97% were of mild intensity, ... TAKHZYRO demonstrated that subcutaneous injections every two or four weeks reduced the mean monthly number of attacks across ... TAKHZYRO has a half-life of approximately two weeks and may be self-administered as one subcutaneous injection every two weeks ... Shire Receives European Approval for TAKHZYRO™ (lanadelumab) subcutaneous injection, for the Preventive Treatment of Hereditary ...
Safety Study of Ibalizumab Subcutaneous Injection in Healthy Volunteers (TMB-108). The safety and scientific validity of this ... The is a blinded safety study of ibalizumab given by subcutaneous injection in sequentially increasing dose-groups of at-risk, ... Biological: ibalizumab (biologic/MAb) for SC Injection or placebo ibalizumab or matching placebo administered by subcutaneous ... Biological: ibalizumab (biologic/MAb) for SC Injection or placebo ibalizumab or matching placebo administered by subcutaneous ...
FDA approves Herceptin Hylecta for subcutaneous injection in certain HER2-positive breast cancers. Basel, 28 February 2019 ... for subcutaneous (under the skin) injection for the treatment of certain people with HER2-positive early breast cancer (node- ... The subcutaneous formulation of Herceptin was first approved in Europe in 2013 and is now approved in 100 countries worldwide. ... Herceptin Hylecta (subcutaneous Herceptin) is a combination of trastuzumab and Halozyme Therapeutics Enhanze® drug delivery ...
Part 2 of this two-part series on injection techniques describes the evidence base and procedure for administering a ... Injection technique 2: administering drugs via the subcutaneous route. 28 August, 2018 ... two-part series on injection techniques describes the evidence base and procedure for administering a subcutaneous injection ...
Part 2 of this two-part series on injection techniques describes the evidence base and procedure for administering a ... The First UK Injection Technique Recommendations.. Hunter J (2008) Subcutaneous injection technique. Nursing Standard; 22: 21, ... Angle of injection. It is recommended that subcutaneous injections, particularly of insulin, are administered at a 90-degree ... This is not recommended for subcutaneous injections, as there are no major blood vessels in the subcutaneous tissue and the ...
Teijin Pharma and Ipsen announced the launch of Somatuline 60/90/120 mg for subcutaneous injection in Japan for the treatment ... Teijin Pharma and Ipsen announced the launch of Somatuline 60/90/120 mg for subcutaneous injection in Japan for the treatment ... Teijin Pharma to Launch Ipsens Somatuline Subcutaneous Injection in Japan. Jan. 18, 2013 ... Calhoun obtained scrips for Arixtra, an expensive daily injection used to treat or prevent blood clots. ...
Blue Cross Blue Shield of Massachusetts is an Independent Licensee of the Blue Cross and Blue Shield Association. ® Registered Marks of the Blue Cross and Blue Shield Association. ®´ Registered Marks of Blue Cross and Blue Shield of Massachusetts, Inc., or Blue Cross and Blue Shield of Massachusetts HMO Blue, Inc. ®´´ Registered Marks, TM Trademarks. and SM Service Marks are the property of their respective owners. © 2020 Blue Cross and Blue Shield of Massachusetts, Inc., or Blue Cross and Blue Shield of Massachusetts HMO Blue, Inc.. ...
  • Interferon beta-1a subcutaneous injection comes as a solution (liquid) in a prefilled syringe or a prefilled automatic injection device to inject subcutaneously (under the skin). (medlineplus.gov)
  • Use a new prefilled syringe or prefilled automatic injection device each time you inject your medication. (medlineplus.gov)
  • Always look at the medication in your prefilled syringe or automatic injection device before you use it. (medlineplus.gov)
  • If the solution is cloudy, discolored, or contains particles or if the expiration date marked on the syringe or automatic injection device has passed, do not use that syringe or device. (medlineplus.gov)
  • Use a new needle and syringe with every injection. (healthline.com)
  • Remove all air bubbles from the syringe before injection. (doctors-hospital.net)
  • Through subcutaneous injection port physician prescribed medications can be directly injected into the subcutaneous tissue using a standard needle and syringe, an injection pen, or other manual injection device. (medgadget.com)
  • Insulin is injected through a syringe into subcutaneous injection port. (medgadget.com)
  • While the injection site dries, double-check that you have the right amount of medicine in your syringe. (baycare.org)
  • If there is no blood in the syringe, continue with the injection. (baycare.org)
  • Can I use 3cc syringe for subcutaneous injection? (healthtap.com)
  • Injections are used to distribute medication through a needle or syringe. (ukessays.com)
  • Representative Director and President, Fabrice Baschiera (hereinafter 'Sanofi')) announced that they will launch 'Squarekids® subcutaneous injection syringe', a tetravalent combination vaccine (DPT-IPV) for the prevention of diphtheria, pertussis, tetanus and poliomyelitis (polio) on December 9, 2015. (fiercepharma.com)
  • Have this close by so you can throw the syringe and needle away right after your injection. (oncolink.org)
  • While keeping the skin pinched, slowly push the plunger on the syringe to push the medication into your subcutaneous tissue. (oncolink.org)
  • I want to go to twice weekly injections but it will tough in a standard 3ml syringe. (evolutionary.org)
  • An injection (often referred to as a "shot" in US English, a "jab" in UK English, or a "jag" in Scottish English and Scots) is the act of administering a liquid, especially a drug, into a person's body using a needle (usually a hypodermic needle) and a syringe. (wikipedia.org)
  • Medicines you give just below the skin are called subcutaneous (SC) or SubQ injections. (stjude.org)
  • I have taken HGH alone for 6 months in the past using SubQ injections to my stomach fat. (anabolicminds.com)
  • For me, I think I would prefer SubQ injections into belly fat because of my experience injecting HGH in this way. (anabolicminds.com)
  • Check out following: http://www.Drugs.Com/cg/how-to-give-a-subcutaneous-injection.Html, http://www.Cc.Nih.Gov/ccc/patient_education/pepubs/subq.Pdf & http://www.Wikihow.Com/give-a-subcutaneous-injection. (healthtap.com)
  • This is known as a subcutaneous (SC or subQ) injection. (emedtv.com)
  • depo-subQ Provera injection [package insert]. (emedtv.com)
  • After some advice from a couple guys on the forum and plenty of research, I've decided to try subQ injections. (evolutionary.org)
  • As far as I know the only option would be a slin pin and subQ injections. (evolutionary.org)
  • Patients with cancer who take methotrexate injection (subcutaneous) may be at a greater risk of getting a bad health problem called tumor lysis syndrome (TLS). (drugs.com)
  • However, elderly patients are more likely to have liver or kidney problems, which may require caution and an adjustment in the dose in patients receiving methotrexate injection. (mayoclinic.org)
  • In the multi-center, global HAVEN 3 study, patients aged 12 years and older were given a skin [subcutaneous] injection of new protein called emicizumab, which performs the same function as the missing FVIII. (news-medical.net)
  • The injections were administered weekly in one group, every second week in another group and then the patients' number of bleeds measured when compared to those not receiving emicizumab. (news-medical.net)
  • Instruct patients on the proper use of ZEMBRACE SymTouch and direct them to use injection sites with an adequate skin and subcutaneous thickness to accommodate the length of the needle. (rxlist.com)
  • BD is releasing its new Nano pen needle designed for achieving consistent depth during subcutaneous injections, particularly for diabetic patients on insulin. (medgadget.com)
  • Dublin, Ireland - 30 November 2018 - Shire plc (LSE: SHP, NASDAQ: SHPG), the leading global biotechnology company focused on rare diseases, today announced that the European Commission (EC) has granted Marketing Authorisation for TAKHZYRO™ (lanadelumab) subcutaneous injection, for routine prevention of recurrent attacks of hereditary angioedema (HAE) in patients aged 12 years and older. (yahoo.com)
  • The current study will compare the different efficacy of two transient intensive insulin treatment strategies: Continuous subcutaneous insulin infusion (CSII) and multiple daily insulin injections (MDI) in patients who are not well controlled with oral hypoglycaemic agents. (clinicaltrials.gov)
  • Patients will be given Continuous Subcutaneous Insulin Infusion during two weeks confinement in the hospital. (clinicaltrials.gov)
  • Patients will be given Transient multiple daily insulin injections during two weeks confinement in the hospital. (clinicaltrials.gov)
  • In this semirandomized, open-label study evaluating the manual pressure method for transient analgesia, physicians applied pressure with their thumbs for 10 seconds to create a nonpainful skin depression at the injection site immediately before subcutaneous injection of the influenza vaccine to patients. (dovepress.com)
  • Benlysta, shown here in vials, will be available soon as an under-the-skin injection for patients with systemic lupus erythematosus (SLE). (fiercepharma.com)
  • In preliminary conversations, some payers have said they may allow patients to switch from the IV version to the subcutaneous formula, Mullen said. (fiercepharma.com)
  • The proportion of patients taking Benlysta's subcutaneous formula could become quite hefty. (fiercepharma.com)
  • Mullen said the company is "attempting to provide IV and subcutaneous at a parity-very comparable cost-so we enable this choice for patients," she said. (fiercepharma.com)
  • This study assessed adherence, in daily life, to subcutaneous (sc) IFN beta-1a, self-administered using the RebiSmart ® electronic injection device (the IFN beta-Ia autoinjector device), in patients with MS. (dovepress.com)
  • This was a retrospective observational study analyzing treatment adherence based on injection data, eg, injection date and dose, extracted from the IFN beta-Ia autoinjector devices collected from patients in Germany and the Netherlands. (dovepress.com)
  • The injection data stored electronically in the device may help patients to adhere to treatment regimens and, if viewed by physicians, promote discussion of adherence issues with patients. (dovepress.com)
  • Standards for medicine management (NMC 2008a) Adopting a skilled injection technique may make the patients experience less painful and prevent unnecessary complications, whereas poor understanding of the technique could result in the injection being administrated intramuscular which could affect the rate of absorption and cause potential harm to the patient (Hunter 2008). (ukessays.com)
  • Effects of subcutaneous and intravenous golimumab on inflammatory biomarkers in patients with rheumatoid arthritis: results of a phase 1, randomized, open-label trial. (umassmed.edu)
  • Many diabetic patients taking multiple subcutaneous insulin injections cannot adjust their dosage appropriately to maintain blood glucose within a normal range. (physiology.org)
  • The leading drug in Genta's small molecule program is Ganite(R) (gallium nitrate injection), which the Company is exclusively marketing in the U.S. for treatment of symptomatic patients with cancer related hypercalcemia that is resistant to hydration. (bio-medicine.org)
  • SHANGHAI & OSAKA, Japan --(BUSINESS WIRE)--Dec. 8, 2020-- Takeda Pharmaceutical Company Limited ( TSE:4502/NYSE:TAK ) ("Takeda") today announced that China's National Medical Products Administration (NMPA) has approved TAKHZYRO ® (lanadelumab) subcutaneous injection for prophylaxis to prevent attacks of hereditary angioedema ( HAE) in patients 12 years and older. (ft.com)
  • In clinical trials, the majority of patients took within 10 to 60 seconds to administer the injection. (ft.com)
  • To compare the pharmacokinetics/dynamics of the long-acting insulin analog glargine with NPH, ultralente, and continuous subcutaneous (SC) infusion of insulin lispro (continuous subcutaneous insulin infusion [CSII]), 20 C-peptide-negative type 1 diabetic patients were studied on four occasions during an isoglycemic 24-h clamp. (diabetesjournals.org)
  • Patients received SC injection of either 0.3 U/kg glargine or NPH insulin (random sequence, crossover design). (diabetesjournals.org)
  • In two U.S. clinical trials involving 1,104 migraine patients with moderate or severe migraine pain, a 6-mg subcutaneous dose of sumatriptan injection resulted in a rapid onset of relief (less than 10 minutes). (andhranews.net)
  • Headache relief, as evidenced by a reduction in pain from severe or moderately severe to mild or no headache, was achieved in 70 percent of patients within 1 hour of a single 6-mg subcutaneous injection of sumatriptan (compared with 18 percent [study 1] and 26 percent [study 2] receiving placebo). (andhranews.net)
  • Patients were randomly assigned in a 3 : 3 : 2 : 2 ratio to receive placebo injections plus methotrexate capsules (group 1, n = 133), golimumab 100 mg injections plus placebo capsules (group 2, n = 133), golimumab 50 mg injections plus methotrexate capsules (group 3, n = 89), or golimumab 100 mg injections plus methotrexate capsules (group 4, n = 89). (bmj.com)
  • Examination of a further 73 type 1 patients revealed lipohypertrophy in 44% and hard subcutaneous nodules on two. (bmj.com)
  • Insulin injections can cause a variety of subcutaneous changes, particularly if patients do not rotate sites. (bmj.com)
  • Examination of 73 further patients with type 1 diabetes revealed lipohypertrophy in many cases, two of whom had also developed hard subcutaneous nodules. (bmj.com)
  • The injection sites of 73 other consecutive patients with type 1 diabetes (48% male), mean age 31 years, mean duration of diabetes 13.6 years, and mean HbA1c 9.5% were examined. (bmj.com)
  • Thirty three patients (45 %) had not had their injection sites examined at their last annual review. (bmj.com)
  • The majority of patients (42) stated that they rotated insulin injection sites on a regular basis, while 31 patients tended to stick to one main area, although rotation within that area was reported. (bmj.com)
  • Background Subcutaneous injections of anti-CD20 antibodies may offer benefits to both patients and the healthcare system for treatment of B-cell malignancies. (haematologica.org)
  • Design and Methods A pilot study was undertaken to evaluate the potential for subcutaneous dosing with 2nd generation anti-CD20 antibody veltuzumab in patients with CD20 + indolent non-Hodgkin's lymphoma. (haematologica.org)
  • Effectiveness of dry cold application on pain intensity and bruise at the subcutaneous injection site among patients admitted in selected hospital of Mullana Ambala. (indianjournals.com)
  • Intensive glucose control (3 or more daily insulin injections or continuous subcutaneous insulin infusion) reduced the mean risk of retinopathy progression by 54% in type 1 diabetes patients with minimal-to-moderate retinopathy. (silverbook.org)
  • Intensive glucose control (3 or more daily insulin injections or continuous subcutaneous insulin infusion) reduced the mean risk of retinopathy by 76% in type 1 diabetes patients who had not developed retinopathy. (silverbook.org)
  • The prefilled Makena auto-injector offers a new administration option for patients and providers and contains a shorter, thinner non-visible needle compared to the intramuscular (IM) Makena injection. (businessinsider.com)
  • The Makena subcutaneous auto-injector offers healthcare providers an important alternative mode of delivery for patients at risk of recurrent preterm birth. (businessinsider.com)
  • Clinical Trial of Subcutaneous Steroid Injection in Patients with Migraine Disorder', Iranian Journal of Medical Sciences , 41(1), pp. 9-12. (ac.ir)
  • Background: Neurologic literature on therapeutic effect of subcutaneous corticosteroids in patients with migrainous chronic daily headache is scarce. (ac.ir)
  • Two cases developed subcutaneous fat atrophy in frontal injection site and three cases experienced syncope during injection.Conclusion: Subcutaneous corticosteroids could be used as an adjunct therapy in patients with migrainous chronic daily headache. (ac.ir)
  • For individuals with painful subcutaneous lipoma, intralesional injection of 40mg/mL of triamcinolone acetonide is an effective and safe alternative to surgical excision or injection of sclerosing agents and should be considered as a reasonable therapeutic alternative in select patients. (jcadonline.com)
  • This was a cohort study consisting of a case series of eight patients with symptomatic subcutaneous lipoma who wished to avoid surgical extirpation and thus asked to have the lesions injected. (jcadonline.com)
  • Although it takes longer for the drug to reach the blood circulation, recent studies in populations of patients undergoing surgery receiving subcutaneous tramadol showed that it was effective at achieving significantly reduced pain within 30 minutes. (isrctn.com)
  • Comparison between subcutaneous tramadol and intravenous tramadol has not been studied before in the population of emergency department patients with moderate pain caused injuries to their extremities. (isrctn.com)
  • Patients then are allocated into receiving either intravenous tramadol or subcutaneous tramadol. (isrctn.com)
  • This review assessed the efficacy of intermittent subcutaneous apomorphine injections for the management of 'off' episodes in patients with Parkinson's disease. (york.ac.uk)
  • To review the clinical efficacy and tolerability, as well as the pharmacology, of intermittent subcutaneous apomorphine injections for the management of 'off' episodes (motor fluctuations due to the waning effect of dopaminergic drugs) in patients with Parkinson's disease (PD). (york.ac.uk)
  • Greatly reduces injection movements and forces to alleviate the agony otherwise experienced by manual injection.Prefilled Cartridge and disposable needles being Compatible with market popular product for flexible choice.Rated as accuracy injection pen by healthcare professionals and patients. (remastersys.com)
  • The administration of long acting injectable medications in the deltoid muscle is viewed as an alternative to the injection using the gluteal muscles by a considerable number of patients. (scirp.org)
  • Nevertheless, some patients experience increased injection site pain through this application while others perceive the change as beneficial in terms of practicability [4]. (scirp.org)
  • Randomized Trial of Continuous Subcutaneous Delivery of Exenatide by ITCA 650 Versus Twice-Daily Exenatide Injections in Metformin-Treated Type 2 Diabetes. (diabetesjournals.org)
  • An alternative method of insulin administration is the continuous subcutaneous insulin infusion pump (CSII). (cochrane.org)
  • To compare, in a long-term study, glycemic control by means of continuous subcutaneous insulin infusion (CSII or insulin pump therapy) versus multiple insulin injection therapy (MIIT) in routine clinical practice. (nih.gov)
  • Pharmacokinetics and pharmacodynamics of subcutaneous injection of long-acting human insulin analog glargine, NPH insulin, and ultralente human insulin and continuous subcutaneous infusion of insulin lispro. (diabetesjournals.org)
  • The MDS-Device Aided Medical Therapy Module 8 course will provide a comprehensive overview to the introduction and complications of subcutaneous apomorphine injections and continuous infusions. (movementdisorders.org)
  • The primary purpose of this program is to provide information on the introduction and complications of subcutaneous apomorphine injections and continuous infusions. (movementdisorders.org)
  • Continuous subcutaneous insulin infusion versus multiple daily injections in adolescents with type I diabetes mellitus: a randomized open crossover trial. (semanticscholar.org)
  • Intensive therapy for type 1 diabetes mellitus (DM) is usually provided by either multiple daily injections of insulin (MDI) or by insulin pump (continuous subcutaneous insulin infusion CSII). (semanticscholar.org)
  • Continuous subcutaneous insulin infusion versus multiple daily injections in children and young people at diagnosis of type 1 diabetes: the SCIPI RCT. (semanticscholar.org)
  • This type of injection may be beneficial for medications such as insulin and heparin that require continuous absorption (Shepherd 2018). (ausmed.com)
  • Injections generally administer a medication as a bolus (or one-time) dose, but can also be used for continuous drug administration. (wikipedia.org)
  • BERKELEY HEIGHTS, N.J., June 06, 2007 /PRNewswire-FirstCall/ -- Genta Incorporated announced the publication of preliminary clinical results that show the Company's lead anti-cancer drug, Genasense(R) (oblimersen sodium) injection, can be safely administered by intermittent subcutaneous (SC) injection, as well as by brief intravenous (IV) infusion. (bio-medicine.org)
  • Medications administered by subcutaneous injection include drugs that can be given in small volumes (usually less than 1 mL but up to 2 mL is safe). (healthline.com)
  • SC injections involve depositing medications into the loose connective tissue underlying the dermis, this tissue is not a richly supplied with blood vessels as muscles are thus allowing the medication to be absorbed slowly. (ukessays.com)
  • A subcutaneous injection is a way to give certain medications using a needle. (oncolink.org)
  • Intralesional injection of sterile medications remains a mainstay in dermatology, enabling a tailored, low-cost, in-office therapy. (physiciansweekly.com)
  • Subcutaneous injections are highly effective in administering medications such as insulin, morphine, diacetylmorphine and goserelin. (wikipedia.org)
  • Medications commonly administered via subcutaneous injection include insulin, monoclonal antibodies, and heparin. (wikipedia.org)
  • Additionally, subcutaneous injections are a less expensive, easier and sometimes more effective way of administering certain medications (Case-Lo 2018). (ausmed.com)
  • An intramuscular injection (IMI) is a method of administering medications deep into the central area of specific muscle tissues. (scirp.org)
  • Medications administered via a systemic injection will enter into blood circulation, either directly or indirectly, and thus will have an effect on the entire body. (wikipedia.org)
  • Aluminum--based adjuvants induce persistent, sterile, subcutaneous granulomas with macrophage-driven translocation of aluminum to regional lymph nodes in sheep. (greenmedinfo.com)
  • ZEMBRACE SymTouch is a clear, colorless to pale yellow, sterile, nonpyrogenic solution for subcutaneous injection. (rxlist.com)
  • ZEMBRACE SymTouch 3 mg/0.5 mL Injection contains sumatriptan as the succinate salt and is supplied as a clear, colorless to pale yellow, sterile, nonpyrogenic solution in a prefilled, ready-to-use, single dose, disposable auto-injector unit ( NDC # 67857-809-37). (rxlist.com)
  • ABRILADA (adalimumab-afzb) injection is supplied as a sterile, preservative-free solution for subcutaneous administration. (rxlist.com)
  • Subcutaneous injection ports are sterile medication delivery device. (medgadget.com)
  • In-office compounding for intralesional dermal and subcutaneous administration is safe when sterile products are used by medical practitioners. (physiciansweekly.com)
  • This has led to the development of needle exchange programs and safe injection sites as a public health measure, which may provide new, sterile syringes and needles to discourage the reuse of syringes and needles. (wikipedia.org)
  • Regardless of classification, injections require a puncture to be made, thus requiring sterile environments and procedures to minimize the risk of introducing pathogens into the body. (wikipedia.org)
  • Giving yourself a subcutaneous injection (also called a sub-Q injection) means inserting medicine into the fatty areas just under your skin. (baycare.org)
  • If you need to give yourself a subcutaneous injection, your provider will give you specific instructions. (oncolink.org)
  • You may not be a pro the first time you give yourself a subcutaneous injection. (oncolink.org)
  • You administer a subcutaneous injection just under the skin and above the muscle. (dailypuppy.com)
  • Extensive Atrophy of Subcutaneous Fat Following the Repeated Injections of Insulin. (annals.org)
  • The injection of triamcinolone acetonide is typically used to locally treat inflammatory conditions of the skin, joints, and other musculoskeletal structures, but major toxicities of injection with potent corticosteroid esters include depigmentation, atrophy of the skin, and lipoatrophy (Figure 3). (jcadonline.com)
  • 7-10 We hypothesized that the adverse effect of lipoatrophy predictably caused by 40mg/mL triamcinolone acetonide could be used beneficially to nonsurgically atrophy symptomatic subcutaneous lipomas, resulting in symptomatic improvement. (jcadonline.com)
  • Is Implants or Fat Injections Better For Facial Volume Loss Due To Subcutaneous Atrophy? (eppleyplasticsurgery.com)
  • Clients are enabled to participate in the assessment and development of a subcutaneous injection plan that includes dosage measurement and calculation. (ausmed.com)
  • You will receive your first dose of interferon beta-1a subcutaneous in your doctor's office. (medlineplus.gov)
  • Injection: 3 mg sumatriptan in 0.5 mL prefilled, ready-to-use, single dose, disposable auto-injector. (rxlist.com)
  • Knowledge of dose linearity, plasma clearance, rate and extent of subcutaneous (SC) and intramuscular (IM) absorption of soluble aluminium (Al) citrate is considered a prerequisite for evaluation of toxicokinetic data obtained from SC or IM administration of Al adjuvants in medicinal products. (nih.gov)
  • The is a blinded safety study of ibalizumab given by subcutaneous injection in sequentially increasing dose-groups of at-risk, HIV-negative, healthy volunteers. (clinicaltrials.gov)
  • The study involves the administration of four total injections of ibalizumab or matching placebo in each volunteer, given once every week, at one of three dose levels. (clinicaltrials.gov)
  • After 4 of 8 volunteers in the first group have received all study drug injections and have completed 6 additional weeks of follow-up, an independent safety monitoring group will review available data before approving initiation of the next higher dose-group. (clinicaltrials.gov)
  • An independent data safety monitoring board (DSMB) will review study data after four out of eight at-risk HIV-negative volunteers in Group 1 (120 mg dose) have received all study drug injections and completed 6 weeks of follow-up before approving escalation to Group 2 (240 mg dose). (clinicaltrials.gov)
  • The DSMB will also review all available study data from Groups 1, and 2 after four out of eight volunteers in Group 2 have received all study drug injections and completed 6 weeks of follow-up before approving escalation to Group 3 (480 mg dose). (clinicaltrials.gov)
  • A mean of 94.8% of the multi-dose cartridges (containing sc IFN beta-1a for three injections) were used completely, indicating a low incidence of application errors and drug wastage. (dovepress.com)
  • The purpose of this study is to characterize the pharmacokinetic (PK) profile of pembrolizumab (MK-3475) following single subcutaneous (SC) injection of pembrolizumab Dose A versus pembrolizumab Dose C in adults with advanced melanoma. (centerwatch.com)
  • In a dose-ranging pharmacokinetic (PK) and pharmacodynamic trial, bolus SC injections of 75, 150 and 225 mg yielded dose-proportional plasma concentrations that were associated with down-regulation of Bcl-2 in blood cells. (bio-medicine.org)
  • Booster immunization: The usual booster dose for children is a single 0.5 mL dose given by subcutaneous injection at least 6 months after the primary immunization. (fiercepharma.com)
  • Conclusions Subcutaneous injections of low-dose veltuzumab are convenient, well tolerated, and capable of achieving sustained serum levels, B-cell depletion, and durable objective responses in indolent non-Hodgkin's lymphoma. (haematologica.org)
  • AMAG expects the subcutaneous auto-injector to be available in the second half of March, and the company will continue to offer the IM formulation of Makena in both single-dose and multi-dose vials. (businessinsider.com)
  • The dose per injection varied between studies. (york.ac.uk)
  • The dose scale automatically returns to zero after injection to allow visual confirmation of dose delivery. (remastersys.com)
  • Other methods, like intravenous injection, can be difficult and costly. (healthline.com)
  • Aluminium toxicokinetics after intramuscular, subcutaneous, and intravenous injection of Al citrate solution in rats. (nih.gov)
  • An intravenous injection provides the quickest onset of the desired effects because the substance immediately enters the blood, and is quickly circulated to the rest of the body. (wikipedia.org)
  • Many other vaccines are administered as an intramuscular injection - into muscle tissue rather than under the skin. (healthline.com)
  • In a study, this design helped to achieve more reliable injections which led to an 8-fold decrease in "calculated intramuscular injection risk," according to BD. (medgadget.com)
  • Women were excluded if they had used any of these contraceptive methods within the 2 months before enrolment or had received an intramuscular injection of medroxyprogesterone within 10 months before enrolment. (mims.co.uk)
  • An intramuscular injection (IMI) is an injection given directly into the central area of a specific muscle. (scirp.org)
  • These signals can be provided by pathogens or the subcutaneous injection route, which can convert them from tolerogenic to immunogenic DC. (nih.gov)
  • These findings are important for selecting the appropriate injection route of human DC for tumor immunotherapy. (nih.gov)
  • The review considers the favourable and unfavourable effects, the uncertainty of the effects and the possible mode of action of the subcutaneous route of administration. (echamp.eu)
  • The most common reasons for preferring the deltoid muscle for IMIs instead of other muscles include easier access, enhanced privacy causing less embarrassment due to exposure of human body parts, and faster administration with the expectation of less pain, than injection through the gluteus route. (scirp.org)
  • An injection is considered a form of administering drugs via the parenteral route, which refers to routes of administration which do not involve absorption in the digestive tract. (wikipedia.org)
  • Subcutaneous (SQ or Sub-Q) injection means the injection is given in the fatty tissue, just under the skin. (medlineplus.gov)
  • Your injection site should be healthy, meaning there should be no redness, swelling, scarring, or other damage to your skin or the tissue below your skin. (medlineplus.gov)
  • In this type of injection, a short needle is used to inject a drug into the tissue layer between the skin and the muscle. (healthline.com)
  • The lesion was excised and the 4×2×2 cm mass of subcutaneous tissue seemed to consist solely of fibroadipose tissue. (bmj.com)
  • Microscopically, we identified a widespread infiltrate of plasma cells, lymphocytes, and eosinophils within the subcutaneous adipose tissue, in a septal and lobular distribution, indicating inflammation or panniculitis. (bmj.com)
  • Lister & Dougherty 2008) suggests upper arm as a most favourable choice as they contain fewer large blood vessels and less painful sensations, however in practice the abdomen is a more common site for heparin as the skin contains a thicker subcutaneous tissue (Hunter 2008).It has been expressed that rotation of sites can decrease the likely hood of irritation and ensure improved absorption (Dougherty and Lister 2009). (ukessays.com)
  • Abdominal wall injection sites showing bilateral areas of lipohypertrophy which contained hard "golf balls" of fibrocollagenous scar tissue. (bmj.com)
  • The subcutaneous tissue, also known as the hypodermis, is the innermost (deepest) layer of skin. (oncolink.org)
  • Medication is absorbed more slowly when it is given into the subcutaneous tissue rather than into a vein (IV) or muscle. (oncolink.org)
  • Some people have more subcutaneous tissue than others. (oncolink.org)
  • Pinching and pulling gently will pull the subcutaneous tissue away from the muscle. (oncolink.org)
  • Subcutaneous tissue has few blood vessels and so drugs injected here are for slow, sustained rates of absorption. (wikipedia.org)
  • A subcutaneous injection is administered into the fatty tissue of the subcutaneous tissue, located below the dermis and epidermis. (wikipedia.org)
  • An insulin pump consists of a catheter which is inserted into the subcutaneous tissue, and then secured in place to allow insulin to be administered multiple times through the same injection site. (wikipedia.org)
  • Rotating the injection site is the primary method of preventing changes in tissue structure from insulin administration. (wikipedia.org)
  • I have lost all collagen, subcutaneous tissue, and tissue and facial padding. (eppleyplasticsurgery.com)
  • Subcutaneous injections are used to administer medication into the fatty tissue layer between the skin and the muscle. (ausmed.com)
  • The needle must be injected into a site with a layer of subcutaneous tissue. (ausmed.com)
  • With your non-dominant hand, lift a 5 cm fold of skin to separate the subcutaneous layer from the muscle tissue underneath. (ausmed.com)
  • There are many types of injection, which are generally named after the body tissue the injection is administered into. (wikipedia.org)
  • Injections are classified in multiple ways, including the type of tissue being injected into, the location in the body the injection is designed to produce effects, and the duration of the effects. (wikipedia.org)
  • Methotrexate injection is used alone or together with other medicines to treat several types of cancer, such as breast, head and neck, lung, blood, bone, lymph node, and uterus cancers. (mayoclinic.org)
  • Hyaluronidase injection is also used to increase absorption of fluids or medicines that are injected into your skin. (adam.com)
  • I'm currently writing a paper on absorption rates of different injections. (allnurses.com)
  • The sensitivity coefficient for absorption suggests a significant overlapping injection effect that is not considered in present patient management strategies. (physiology.org)
  • It also used to help improve absorption of radioactive substances during a procedure called subcutaneous urography. (adam.com)
  • Another benefit from subcutaneous tramadol is that it is associated with less side effects such as nausea and drowsiness compared to intravenous tramadol due to slower absorption into the blood stream. (isrctn.com)
  • While attempts have been made since the 1920s to administer insulin orally, the large size of the molecule has made it difficult to create a formulation with absorption and predictability that comes close to subcutaneous injections of insulin. (wikipedia.org)
  • This can lead to slower or incomplete absorption from the injection site. (wikipedia.org)
  • Therefore, it was considered that a long acting injection is better administered intramuscularly using the gluteal muscles, and we have to consider the volume, property of drug and its safety and absorption such as damage to tissues including subcutaneous and blood vessel or peripheral nerve. (scirp.org)
  • The nurse will show you the following steps and give you time to practice before you give a subcutaneous injection to your child. (stjude.org)
  • Traditionally, insulin is given as multiple daily injections (MDI), however a small pump can continuously give insulin through a fine tube under the skin (CSII). (cochrane.org)
  • On two subsequent occasions, they received either an SC injection of ultralente (0.3 U/kg) or CSII (0.3 U x kg(-1) x 24 h(-1)) (random sequence, crossover design). (diabetesjournals.org)
  • After SC insulin injection or CSII, intravenous (IV) insulin was tapered, and glucose was infused to clamp plasma glucose at 130 mg/dl for 24 h. (diabetesjournals.org)
  • Genta Announces Results of Phase 1 Study Using Genasense,Administered by Intermittent Subcutaneous Injection ( Study Shows Safety and Pharmacokinetics. (bio-medicine.org)
  • Studies of intermittent subcutaneous injections of apomorphine were eligible for inclusion. (york.ac.uk)
  • Once the needle is all the way in, slowly press down on the plunger or injection button to inject all the medicine. (medlineplus.gov)
  • The injections should be spaced at least 48 hours apart, so it is best to inject your medication around the same time of day on each of your injection days. (medlineplus.gov)
  • After that, you can inject interferon beta-1a subcutaneous yourself or have a friend or relative perform the injections. (medlineplus.gov)
  • Talk to your doctor or pharmacist about where on your body you should inject interferon beta-1a subcutaneous. (medlineplus.gov)
  • If you are very thin, only inject in your thigh or the outer surface of your arm for injection. (medlineplus.gov)
  • Some people are worried they will inject too deeply and so end up giving an intradermal injection which is painful and not absorbed as well. (lymphomation.org)
  • If you try and inject it too rapidly it increases the pressure and the pain of the injection. (lymphomation.org)
  • Don't ever inject distilled water or use table salt to make saline for injection. (backyardchickens.com)
  • The new subcutaneous option will allow them to inject themselves. (fiercepharma.com)
  • He said about the injection volume, just inject more often but only .5cc each time. (anabolicminds.com)
  • The ability to inject high concentrations of proteins via subcutaneous injections would increase accessibility and compliance. (utexas.edu)
  • This type of injection can be given by a healthcare professional, or a patient can self-inject. (foundhealth.com)
  • This was a self administered subcutaneous injection (20 mg three times a week), which she started 12 months before presentation. (bmj.com)
  • TAKHZYRO has a half-life of approximately two weeks and may be self-administered as one subcutaneous injection every two weeks, only after training by a healthcare professional. (ft.com)
  • Subcutaneous injection is considered a standard method for the delivery of medication into a patient's body. (medgadget.com)
  • Unlike the intravenous way, subcutaneous injection does not require leaving a cannula in the patient's skin after the drug has been administered. (isrctn.com)
  • Therefore this study aims to compare the effectiveness of both methods of injection in terms of pain relief, and also compare the occurrence of side effects, pain associated with intravenous cannulation and subcutaneous injection, and patient's overall satisfaction. (isrctn.com)
  • Confirming the patient's identity through three identifiers and their need for subcutaneous injections. (ausmed.com)
  • Calhoun obtained scrips for Arixtra, an expensive daily injection used to treat or prevent blood clots. (fdanews.com)
  • Also you could get a nurse or doctor to watch you administer the injection to make sure its not intradermal. (lymphomation.org)
  • Make sure the injections aren't intradermal as these can be painful. (lymphomation.org)
  • The Infection Rate of Intralesional Triamcinolone and The Safety of Compounding in Dermatology for Intradermal and Subcutaneous Injection: A Retrospective Chart Review. (physiciansweekly.com)
  • Studies demonstrating the safety data of in-office corticosteroid compounding for intradermal or subcutaneous use are lacking. (physiciansweekly.com)
  • It is slower than intramuscular injections but still faster than intradermal injections. (wikipedia.org)
  • For small amounts of delicate drugs, a subcutaneous injection can be a useful, safe, and convenient method of getting a medication into your body. (healthline.com)
  • Other drugs that need to be given very quickly can also be administered via subcutaneous injection. (healthline.com)
  • Drugs that prevent nausea and vomiting like metoclopramide (Reglan) or dexamethasone (DexPak) can also be given via subcutaneous injection. (healthline.com)
  • This is not a list of all drugs or health problems that interact with methotrexate injection. (drugs.com)
  • It is necessary to establish an effective subcutaneous injection procedure for adult and elderly individuals because many drugs such as hormones and interferon are generally delivered by subcutaneous injection. (dovepress.com)
  • The following sections explain in detail the potentially negative interactions that can occur when medroxyprogesterone subcutaneous injection is combined with any of the drugs listed above. (emedtv.com)
  • Subcutaneous injection may also be used by people to (self-)administer recreational drugs. (wikipedia.org)
  • Furthermore, recreational drug users who use injections to administer the drugs commonly share or reuse needles after an injection. (wikipedia.org)
  • Primary immunization: The usual primary series for children consist of three doses of 0.5 mL each given by subcutaneous injection at intervals of at least 3 weeks. (fiercepharma.com)
  • Subcutaneous veltuzumab demonstrated a slow release pattern over several days, achieving a mean Cmax of 19, 25 and 63 μg/mL at 80, 160, and 320 mg doses for a total of 4 administrations, respectively. (haematologica.org)
  • Therefore, veltuzumab was reformulated in a more concentrated form (approximately 80 mg/mL) and this pilot study was undertaken to evaluate the feasibility for delivery of low doses by subcutaneous (SC) injection. (haematologica.org)
  • Methylprednisolone 40 mg was divided into four subcutaneous injection doses. (ac.ir)
  • The FDA approval is based on results from clinical studies, which demonstrated that subcutaneous administration of Rituxan Hycela resulted in non-inferior levels of rituximab in the blood (pharmacokinetics) and comparable clinical efficacy outcomes compared to intravenous Rituxan. (roche.com)
  • Salameh JS, Deeb W, Burawski L, Wright S, Souayah N. Safety and Efficacy of Subcutaneous Immunoglobulin in the Treatment of Neuromuscular Disorders. (umassmed.edu)
  • Sayana Press (medroxyprogesterone acetate) is supplied in a prefilled injection device ready to be injected under the skin into the thigh or abdomen. (mims.co.uk)
  • Sayana Press is a subcutaneous formulation of medroxyprogesterone acetate , which inhibits the secretion of gonadotrophins, thereby preventing follicular maturation and ovulation. (mims.co.uk)
  • Mean weight gain from baseline was similar for women receiving medroxyprogesterone by the subcutaneous or intramuscular routes (3.4kg versus 3.5kg at the end of year 2 and 4.5kg versus 5.8kg at the end of year 3). (mims.co.uk)
  • Subcutaneous medroxyprogesterone was well tolerated in all three studies. (mims.co.uk)
  • Medroxyprogesterone subcutaneous injection is a prescription drug licensed to prevent pregnancy and relieve pain caused by endometriosis. (emedtv.com)
  • Medroxyprogesterone subcutaneous injection contains medroxyprogesterone, a progestin hormone. (emedtv.com)
  • Interested in a Discount on Medroxyprogesterone Subcutaneous Injection? (emedtv.com)
  • If you are using medroxyprogesterone subcutaneous injection as a form of birth control, you may want to use a backup birth control method while taking an antibiotic, just to be safe. (emedtv.com)
  • Combining medroxyprogesterone subcutaneous injection with a corticosteroid may further increase your risk for bone loss, osteoporosis, and fractures. (emedtv.com)
  • Medroxyprogesterone subcutaneous injection may increase the level of cyclosporine in your blood, potentially increasing the chance of side effects. (emedtv.com)
  • Very bad side effects like bone marrow problems, liver problems, lung problems, infections, and skin reactions (Stevens-Johnson syndrome/toxic epidermal necrolysis) can happen with methotrexate injection (subcutaneous). (drugs.com)
  • Very bad and sometimes deadly bone marrow problems and stomach or bowel problems have happened when methotrexate injection was taken with NSAIDs like ibuprofen or naproxen. (drugs.com)
  • If you are pregnant or you get pregnant while taking methotrexate injection, call your doctor right away. (drugs.com)
  • What do I need to tell my doctor BEFORE I take Methotrexate Injection? (drugs.com)
  • If you have an allergy to methotrexate or any other part of methotrexate injection. (drugs.com)
  • What are some things I need to know or do while I take Methotrexate Injection? (drugs.com)
  • Tell all of your health care providers that you take methotrexate injection. (drugs.com)
  • Use with methotrexate injection may either raise the chance of an infection or make the vaccine not work as well. (drugs.com)
  • Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of methotrexate injection for the treatment of cancer and juvenile idiopathic arthritis in children. (mayoclinic.org)
  • Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of methotrexate injection in the elderly. (mayoclinic.org)
  • ONLY HERE Save Over 80% On Prescriptions, The Best QUALITY and LOW PRICES.family-pharmacyonline methotrexate injection subcutaneous or intramuscular . (itconsultora.com)
  • AllDayChemist is one of the leading online pharmacies specializing in providing generic and OTC products methotrexate injection subcutaneous or intramuscular . (itconsultora.com)
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  • 6 Oct 2015 methotrexate injection subcutaneous or intramuscular methot. (itconsultora.com)
  • Day-to-Day U. Kaufen Cialis Online von einer amtlichen zertifizierten Apotheke methotrexate injection subcutaneous or intramuscular . (itconsultora.com)
  • Clean your skin at the injection site with an alcohol pad. (medlineplus.gov)
  • Subcutaneous means under the skin. (healthline.com)
  • Subcutaneous means injected below the skin. (lymphomation.org)
  • The new BD Nano compensates for this by spreading the load across the injection site and preventing the needle from going to far under the surface of the skin. (medgadget.com)
  • A subcutaneous (sub-Q) injection is a shot that delivers medication into the layer of fat between the skin and the muscle. (doctors-hospital.net)
  • Before the injection, press gently in the area to find places where the skin is less sensitive. (doctors-hospital.net)
  • Subcutaneous injection port avoids the repeated needle punctures of the skin. (medgadget.com)
  • A subcutaneous injection port is generally a disposable device usually inserted into the skin for a period of up to 5 days. (medgadget.com)
  • OTCQX: RHHBY) announced today that the US Food and Drug Administration (FDA) approved Rituxan Hycela™ (rituximab and hyaluronidase human) for subcutaneous (under the skin) injection, for the treatment of adults with the following blood cancers: previously untreated and relapsed or refractory follicular lymphoma, previously untreated diffuse large B-cell lymphoma (DLBCL), and previously untreated and previously treated chronic lymphocytic leukaemia (CLL). (roche.com)
  • The most common adverse reactions in people with CLL were infections, neutropenia, nausea, low platelet count (thrombocytopenia), fever (pyrexia), vomiting and reddening of the skin (erythema) at the injection site. (roche.com)
  • Subcutaneous emphysema is a medical term used to indicate a condition where pockets of air have collected underneath the skin. (healthtap.com)
  • Traditionally the technique used when administering subcutaneous injections has been using a 45degree angle into a raised skin fold, however since the introduction of shorter needles and pre filled syringes this has been challenged and it is now recommended that the injections are given at a 90 degree angle into a raised skin fold to ensure medication is given into the SC layer. (ukessays.com)
  • To date, the principal adverse events have been reversible skin reactions at the injection site on the SC schedule and transient fever on the brief IV schedule. (bio-medicine.org)
  • Other advantages of injectables are that active ingredients do not have to pass the gastrointestinal tract or skin barrier, and that the point of injection can be chosen in line with acupuncture trigger points to achieve an optimal systemic or local effect. (echamp.eu)
  • These tend to be places where you can easily access the subcutaneous (fatty areas) under the skin and the needle will not come too close to muscle or bone. (oncolink.org)
  • Two subjects demonstrated some mild hypopigmentation of the skin at four months post-injection. (jcadonline.com)
  • Tramadol can also be administered by subcutaneous injection, meaning using a needle to administer the drug just under the skin. (isrctn.com)
  • Play media A subcutaneous injection is administered as a bolus into the subcutis, the layer of skin directly below the dermis and epidermis, collectively referred to as the cutis. (wikipedia.org)
  • An injection should not be given at a specific site if there is inflammation or skin damage in the area. (wikipedia.org)
  • Lifting the skin fold can help separate the subcutaneous away from the muscle underneath (which should be avoided) (Shepherd 2018). (ausmed.com)
  • This medicine is for injection under the skin. (bcbsla.com)
  • How injection site rotation can help you control your diabetes. (doctors-hospital.net)
  • The global subcutaneous injection ports market is expected to witness a significant growth over the forecast period due to rising prevalence of cancer and diabetes across the globe. (medgadget.com)
  • Asia Pacific is also one of the fast-growing regions in the global subcutaneous injection ports market due to high incidence of diabetes in low-income countries. (medgadget.com)
  • The trials did not provide enough information to know whether an insulin pump or multiple injections are better for a pregnant woman with diabetes or her baby. (cochrane.org)
  • The subcutaneous formulation of Herceptin was first approved in Europe in 2013 and is now approved in 100 countries worldwide. (roche.com)
  • The injectable B12 is the same formulation for subcutaneous use as for intramuscular use. (healthtap.com)
  • An insulin pump may help pregnant women keep their blood glucose more stable than multiple injections. (cochrane.org)
  • This type of injection is used when other methods of administration might be less effective. (healthline.com)
  • Volunteers will be screened up to 42 days prior to enrollment and first drug administration, and will be followed for 26 weeks after the final injection. (clinicaltrials.gov)
  • Comparison of the immunogenicity of intramuscular versus subcutaneous administration of trivalent inactivated influenza vaccine in individuals with neuromuscular diseases. (umassmed.edu)
  • Anthroposophic and homeopathic practitioners often favour injectables as their first choice of medication in the treatment of acute and chronic conditions because of the anticipated quicker and better clinical effect, the possibility to control compliance (the injection is generally given by the physician/therapist or nurse), and the fact that the exact location of administration can be chosen. (echamp.eu)
  • WALTHAM, Mass., Feb. 14, 2018 (GLOBE NEWSWIRE) -- AMAG Pharmaceuticals, Inc. (NASDAQ:AMAG) today announced that the U.S. Food and Drug Administration (FDA) approved the Makena® subcutaneous auto-injector drug-device combination product as a ready-to-administer treatment to reduce the risk of preterm birth in women pregnant with one baby and who spontaneously delivered one preterm baby in the past. (businessinsider.com)
  • AMAG also holds a U.S. patent directed to subcutaneous administration and dosing of the Makena auto-injector product which expires in 2036. (businessinsider.com)
  • Subcutaneous injections can also be used when the increased bioavailability and more rapid effects over oral administration are preferred. (wikipedia.org)
  • They are also the easiest form of parenteral administration of medication to perform by lay people, and are associated with less adverse effects such as pain or infection than other forms of injection. (wikipedia.org)
  • Due to the frequency of injections required for the administration of insulin products via subcutaneous injection, insulin is associated with the development of lipohypertrophy and lipoatrophy. (wikipedia.org)
  • Our purpose was to determine the accuracy of increased thyroid activity for diagnosing hyperthyroidism in cats suspected of having that disease during pertechnetate scintigraphy using subcutaneous rather than intravenous radioisotope administration. (avmi.net)
  • To reduce the risk of infection from injections, proper aseptic technique should be followed to clean the injection site before administration. (wikipedia.org)
  • All injections are considered forms of parenteral administration, which avoids the first pass metabolism which would potentially affect a medication absorbed through the gastrointestinal tract. (wikipedia.org)
  • Before you use interferon beta-1a subcutaneous for the first time, your or the person who will be giving the injections should also read the manufacturer's information for the patient that comes with it. (medlineplus.gov)
  • Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with interferon beta-1a subcutaneous injection and each time you refill your prescription. (medlineplus.gov)
  • They are associated with the appearance of transient injection site nodules corresponding to granulomas. (greenmedinfo.com)
  • Alternative methods of focal transient analgesia should be developed to improve vaccination rates and relieve anxiety associated with subcutaneous injection. (dovepress.com)
  • 5 treatment-naive) completed treatment with only occasional, mild-moderate, transient injection reactions and no other safety issues. (haematologica.org)
  • Insulin and some hormones are commonly administered as subcutaneous injections. (healthline.com)
  • A subcutaneous injection is a method of administering medication. (healthline.com)
  • Conclusions: A once-week SC injection of 50 100 mg of TE appears to achieve sustainable and stable levels of physiological T. This technique offers fewer physician visits and the use of smaller quantity of medication, thus lower costs. (anabolicminds.com)
  • Subcutaneous injections are an easy way to deliver this type of medication. (doctors-hospital.net)
  • ALSUMA is a prescription medication that delivers sumatriptan through subcutaneous injection supplied by a single-use, pre-filled auto-injector that requires minimal steps for use. (andhranews.net)
  • A subcutaneous injection is absorbed slower than a substance injected intravenously or in a muscle, but faster than a medication administered by mouth. (wikipedia.org)
  • Contraindications to subcutaneous injections primarily depend on the specific medication being administered. (wikipedia.org)
  • After injection, a medication may be designed to be released slowly, called a depot injection, which can produce long-lasting effects. (wikipedia.org)
  • Many injections are designed to administer a medication which has an effect throughout the body. (wikipedia.org)
  • Systemic injections may be used when a person cannot take medicine by mouth, or when the medication itself would not be absorbed into circulation from the gastrointestinal tract. (wikipedia.org)
  • Change your injection site from one injection to the next, at least 1 inch apart. (medlineplus.gov)
  • 3. Clean and inspect the injection site. (healthline.com)
  • Infection at the injection site-The chance of side effects may be increased. (mayoclinic.org)
  • Her injection site corresponded with the site of excision so, in view of her negative investigations, signs, and symptoms of lupus erythematosus, we considered the microscopic features to be a direct inflammatory response to mistletoe extract and conducted a review of the literature to compare our findings. (bmj.com)
  • If there is bleeding at the site of injection, apply a bandage. (doctors-hospital.net)
  • Change your injection site in a regular pattern. (doctors-hospital.net)
  • Give new injections at least 1.5 inches away from the last injection site. (doctors-hospital.net)
  • Change the site of the injections each time to reduce discomfort. (doctors-hospital.net)
  • Be careful not to touch the injection site itself. (stjude.org)
  • We tested whether pain during subcutaneous injection can be decreased by prior application of localized manual pressure at the injection site. (dovepress.com)
  • If you are very thin, don't use your belly for your injection site, unless your healthcare provider tells you to. (baycare.org)
  • Choose a site that is at least 2 inches away from your last injection site. (baycare.org)
  • Using an alcohol swab, clean the injection site. (baycare.org)
  • Place your thumb and forefinger on either side of the clean injection site. (baycare.org)
  • Note: The best angle for inserting the needle will depend on your body type, the length of the needle, and the injection site. (baycare.org)
  • Withdraw the needle, select a new injection site, and repeat the steps above for getting the site ready. (baycare.org)
  • The choice of the site of injection is based on sound clinical judgement, best evidence and patient assessment (Potter 2010). (ukessays.com)
  • There are few reports of injection site problems in the recent literature. (bmj.com)
  • Gauze can be useful to apply pressure to the injection site after injecting if you tend to bleed. (oncolink.org)
  • They may be concerned about patient complaints about injection-site reactions (ISRs). (canjurol.com)
  • Injection site reactions may be minimized if repeated injections are necessary by moving the injection site at least one inch from previous injections, or using a different injection location altogether. (wikipedia.org)
  • Heparin-based anticoagulants injected subcutaneously may cause hematoma and bruising around the injection site due to their anticoagulant effect. (wikipedia.org)
  • The most common adverse events (30% or greater) were injection-site reaction, yawning, dyskinesias, drowsiness and nausea or vomiting. (york.ac.uk)
  • If required, cleanse the chosen injection site and wait for it to dry. (ausmed.com)
  • The aim of this study was to determine the influence of body mass index (BMI), subcutaneous fat, and muscular thickness of the dorsogluteal IMI site among healthy Japanese women. (scirp.org)
  • To prevent the localized pain that occurs with injections the injection site may be numbed or cooled before injection and the person receiving the injection may be distracted by a conversation or similar means. (wikipedia.org)
  • Do not reuse or share syringes or automatic injection devices. (medlineplus.gov)
  • Discard used syringes or automatic injection devices in a puncture resistant container that is out of the reach of children. (medlineplus.gov)
  • What are the best smallest syringes to use for subcutaneous injections? (healthtap.com)
  • Depends on what you are injecting, needles are most important for sq injections, 25 or 27 gauge are the best and then you have Insulin syringes, 1, 3 or 5 cc syringes, and the prepackaged syringes for blood-thinners such as Lovenox (enoxaparin) or arixtra, to name a few. (healthtap.com)
  • 4 Such features are also seen in post-steroid panniculitis, where multiple subcutaneous nodules develop up to a month after cessation of steroids. (bmj.com)
  • Fibrocollagenous nodules induced by insulin injections have not been previously described. (bmj.com)
  • We report a case of a previously undescribed phenomenon of bilateral large hard subcutaneous nodules at abdominal wall injection sites. (bmj.com)
  • Rotation of injection sites, avoiding the nodules and areas of lipohypertrophy was advised. (bmj.com)
  • A retrospective chart review identified subjects that received in-office intralesional corticosteroid injections in 2016. (physiciansweekly.com)
  • Charts of 4370 intralesional triamcinolone injections were assessed, 2780/4370 (64%) being compounded triamcinolone with bacteriostatic saline. (physiciansweekly.com)
  • Subcataneous injection sites, showing the average values of the thickness of the subcutaneous fat. (ausmed.com)
  • 6 After discussion with her surgeon, it transpired that the patient had been receiving subcutaneous injections of mistletoe extract as complementary therapy aimed at treating her lymphoma. (bmj.com)
  • I was wondering if anyone knows if the patient can get an abscess from an IM injection that may have gone subcutaneous? (allnurses.com)
  • 1). Unless your patient is cachectic or a bodybuilder, 90+% of 'IM' injection go SQ. (allnurses.com)
  • Intramuscular injections can occur when a patient applies too much force to many of the existing injection devices. (medgadget.com)
  • Furthermore, over the past decade, more patient-friendly devices have enhanced the demand for subcutaneous injection ports. (medgadget.com)
  • It is important to note that each patient has varying levels of subcutaneous fat, so each individual should be assessed before proceeding with the injection. (ausmed.com)
  • If the patient requires frequent injections, you should rotate injection sites to allow each area to heal (Villines 2018). (ausmed.com)
  • Conventionally, insulin has been administered subcutaneously, formally referred to as intensive conventional treatment, but now more usually referred to as multiple daily injections (MDI). (cochrane.org)
  • Injections were administered subcutaneously every 4 weeks. (bmj.com)
  • There is some evidence that administering the injection more slowly may decrease the pain from heparin injections, but not the risk of or extent of bruising. (wikipedia.org)
  • Of course I know everyone is different, but I'm just looking for a baseline injection procedure that is convenient and works for long-term use, and I don't know what you can mix, or what is OK to pin to body fat. (anabolicminds.com)
  • The occurrence of these side effects varies based on injection location, the substance injected, needle gauge, procedure, and individual sensitivity. (wikipedia.org)