Introduction of substances into the body using a needle and syringe.
The top layer of the back muscles whose function is to move the SCAPULA. This group of muscles consists of the trapezius, latissimus dorsi, rhomboid major, rhomboid minor and levator scapulae.
The failure by the observer to measure or identify a phenomenon accurately, which results in an error. Sources for this may be due to the observer's missing an abnormality, or to faulty technique resulting in incorrect test measurement, or to misinterpretation of the data. Two varieties are inter-observer variation (the amount observers vary from one another when reporting on the same material) and intra-observer variation (the amount one observer varies between observations when reporting more than once on the same material).
The statistical reproducibility of measurements (often in a clinical context), including the testing of instrumentation or techniques to obtain reproducible results. The concept includes reproducibility of physiological measurements, which may be used to develop rules to assess probability or prognosis, or response to a stimulus; reproducibility of occurrence of a condition; and reproducibility of experimental results.
Forceful administration into a muscle of liquid medication, nutrient, or other fluid through a hollow needle piercing the muscle and any tissue covering it.
Injections made into a vein for therapeutic or experimental purposes.
Artificial implanted lenses.
Elements of limited time intervals, contributing to particular results or situations.
Injections introduced directly into localized lesions.
Forceful administration under the skin of liquid medication, nutrient, or other fluid through a hollow needle piercing the skin.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
Methods of delivering drugs into a joint space.
Complications that affect patients during surgery. They may or may not be associated with the disease for which the surgery is done, or within the same surgical procedure.
Forceful administration into the peritoneal cavity of liquid medication, nutrient, or other fluid through a hollow needle piercing the abdominal wall.
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
Tomography using x-ray transmission and a computer algorithm to reconstruct the image.
The forcing into the skin of liquid medication, nutrient, or other fluid through a hollow needle, piercing the top skin layer.
The injection of drugs, most often analgesics, into the spinal canal without puncturing the dura mater.
Injections into the cerebral ventricles.
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
Delivery of drugs into an artery.
Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.
The administration of substances into the VITREOUS BODY of the eye with a hypodermic syringe.
Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques.
Introduction of therapeutic agents into the spinal region using a needle and syringe.
The injection of solutions into the skin by compressed air devices so that only the solution pierces the skin.
The administration of substances into the eye with a hypodermic syringe.
Sequential operating programs and data which instruct the functioning of a digital computer.
A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.
The analysis of a chemical substance by inserting a sample into a carrier stream of reagent using a sample injection valve that propels the sample downstream where mixing occurs in a coiled tube, then passes into a flow-through detector and a recorder or other data handling device.
A procedure consisting of a sequence of algebraic formulas and/or logical steps to calculate or determine a given task.
In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test.
The injection of very small amounts of fluid, often with the aid of a microscope and microsyringes.
Models used experimentally or theoretically to study molecular shape, electronic properties, or interactions; includes analogous molecules, computer-generated graphics, and mechanical structures.
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
Abuse, overuse, or misuse of a substance by its injection into a vein.
An assisted fertilization technique consisting of the microinjection of a single viable sperm into an extracted ovum. It is used principally to overcome low sperm count, low sperm motility, inability of sperm to penetrate the egg, or other conditions related to male infertility (INFERTILITY, MALE).
Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.
Instruments used for injecting or withdrawing fluids. (Stedman, 25th ed)
The relationship between the dose of an administered drug and the response of the organism to the drug.
Sharp instruments used for puncturing or suturing.
A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain.
Drugs that block nerve conduction when applied locally to nerve tissue in appropriate concentrations. They act on any part of the nervous system and on every type of nerve fiber. In contact with a nerve trunk, these anesthetics can cause both sensory and motor paralysis in the innervated area. Their action is completely reversible. (From Gilman AG, et. al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed) Nearly all local anesthetics act by reducing the tendency of voltage-dependent sodium channels to activate.
The transparent, semigelatinous substance that fills the cavity behind the CRYSTALLINE LENS of the EYE and in front of the RETINA. It is contained in a thin hyaloid membrane and forms about four fifths of the optic globe.
An esterified form of TRIAMCINOLONE. It is an anti-inflammatory glucocorticoid used topically in the treatment of various skin disorders. Intralesional, intramuscular, and intra-articular injections are also administered under certain conditions.
The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.
A glucocorticoid given, as the free alcohol or in esterified form, orally, intramuscularly, by local injection, by inhalation, or applied topically in the management of various disorders in which corticosteroids are indicated. (From Martindale, The Extra Pharmacopoeia, 30th ed, p739)
Accumulation of a drug or chemical substance in various organs (including those not relevant to its pharmacologic or therapeutic action). This distribution depends on the blood flow or perfusion rate of the organ, the ability of the drug to penetrate organ membranes, tissue specificity, protein binding. The distribution is usually expressed as tissue to plasma ratios.
Drugs used for their actions on skeletal muscle. Included are agents that act directly on skeletal muscle, those that alter neuromuscular transmission (NEUROMUSCULAR BLOCKING AGENTS), and drugs that act centrally as skeletal muscle relaxants (MUSCLE RELAXANTS, CENTRAL). Drugs used in the treatment of movement disorders are ANTI-DYSKINESIA AGENTS.
A serotype of botulinum toxins that has specificity for cleavage of SYNAPTOSOMAL-ASSOCIATED PROTEIN 25.
Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations or by parent x offspring matings carried out with certain restrictions. This also includes animals with a long history of closed colony breeding.
A local anesthetic and cardiac depressant used as an antiarrhythmia agent. Its actions are more intense and its effects more prolonged than those of PROCAINE but its duration of action is shorter than that of BUPIVACAINE or PRILOCAINE.
A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.
Techniques and strategies which include the use of coding sequences and other conventional or radical means to transform or modify cells for the purpose of treating or reversing disease conditions.
Scales, questionnaires, tests, and other methods used to assess pain severity and duration in patients or experimental animals to aid in diagnosis, therapy, and physiological studies.
Usage of a single needle among two or more people for injecting drugs. Needle sharing is a high-risk behavior for contracting infectious disease.
An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.
DNA molecules capable of autonomous replication within a host cell and into which other DNA sequences can be inserted and thus amplified. Many are derived from PLASMIDS; BACTERIOPHAGES; or VIRUSES. They are used for transporting foreign genes into recipient cells. Genetic vectors possess a functional replicator site and contain GENETIC MARKERS to facilitate their selective recognition.
The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.
Substances used to allow enhanced visualization of tissues.
Experimental transplantation of neoplasms in laboratory animals for research purposes.
The various ways of administering a drug or other chemical to a site in a patient or animal from where the chemical is absorbed into the blood and delivered to the target tissue.
The introduction of functional (usually cloned) GENES into cells. A variety of techniques and naturally occurring processes are used for the gene transfer such as cell hybridization, LIPOSOMES or microcell-mediated gene transfer, ELECTROPORATION, chromosome-mediated gene transfer, TRANSFECTION, and GENETIC TRANSDUCTION. Gene transfer may result in genetically transformed cells and individual organisms.
An encapsulated lymphatic organ through which venous blood filters.
The observable response an animal makes to any situation.
A process involving chance used in therapeutic trials or other research endeavor for allocating experimental subjects, human or animal, between treatment and control groups, or among treatment groups. It may also apply to experiments on inanimate objects.
Drugs used in the treatment of movement disorders. Most of these act centrally on dopaminergic or cholinergic systems. Among the most important clinically are those used for the treatment of Parkinson disease (ANTIPARKINSON AGENTS) and those for the tardive dyskinesias.
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations, or by parent x offspring matings carried out with certain restrictions. All animals within an inbred strain trace back to a common ancestor in the twentieth generation.
Mutant mice homozygous for the recessive gene "nude" which fail to develop a thymus. They are useful in tumor studies and studies on immune responses.
Compounds that are used in medicine as sources of radiation for radiotherapy and for diagnostic purposes. They have numerous uses in research and industry. (Martindale, The Extra Pharmacopoeia, 30th ed, p1161)
The basic cellular units of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the NERVOUS SYSTEM.
The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Female germ cells derived from OOGONIA and termed OOCYTES when they enter MEIOSIS. The primary oocytes begin meiosis but are arrested at the diplotene state until OVULATION at PUBERTY to give rise to haploid secondary oocytes or ova (OVUM).
People who take drugs for a non-therapeutic or non-medical effect. The drugs may be legal or illegal, but their use often results in adverse medical, legal, or social consequences for the users.
Lipid-containing polysaccharides which are endotoxins and important group-specific antigens. They are often derived from the cell wall of gram-negative bacteria and induce immunoglobulin secretion. The lipopolysaccharide molecule consists of three parts: LIPID A, core polysaccharide, and O-specific chains (O ANTIGENS). When derived from Escherichia coli, lipopolysaccharides serve as polyclonal B-cell mitogens commonly used in laboratory immunology. (From Dorland, 28th ed)
Unstable isotopes of iodine that decay or disintegrate emitting radiation. I atoms with atomic weights 117-139, except I 127, are radioactive iodine isotopes.
Apparatus, devices, or supplies intended for one-time or temporary use.
A family of non-enveloped viruses infecting mammals (MASTADENOVIRUS) and birds (AVIADENOVIRUS) or both (ATADENOVIRUS). Infections may be asymptomatic or result in a variety of diseases.
Refers to animals in the period of time just after birth.
An antigen solution emulsified in mineral oil. The complete form is made up of killed, dried mycobacteria, usually M. tuberculosis, suspended in the oil phase. It is effective in stimulating cell-mediated immunity (IMMUNITY, CELLULAR) and potentiates the production of certain IMMUNOGLOBULINS in some animals. The incomplete form does not contain mycobacteria.
An increased sensation of pain or discomfort produced by mimimally noxious stimuli due to damage to soft tissue containing NOCICEPTORS or injury to a peripheral nerve.
Substances that reduce or suppress INFLAMMATION.
Viscoelastic solutions that are injected into JOINTS in order to alleviate symptoms of joint-related disorders such as OSTEOARTHRITIS.
Antibodies produced by a single clone of cells.
Any of the ruminant mammals with curved horns in the genus Ovis, family Bovidae. They possess lachrymal grooves and interdigital glands, which are absent in GOATS.
A group of CORTICOSTEROIDS that affect carbohydrate metabolism (GLUCONEOGENESIS, liver glycogen deposition, elevation of BLOOD SUGAR), inhibit ADRENOCORTICOTROPIC HORMONE secretion, and possess pronounced anti-inflammatory activity. They also play a role in fat and protein metabolism, maintenance of arterial blood pressure, alteration of the connective tissue response to injury, reduction in the number of circulating lymphocytes, and functioning of the central nervous system.
Experimentally induced new abnormal growth of TISSUES in animals to provide models for studying human neoplasms.
Proteins prepared by recombinant DNA technology.
A statistical technique that isolates and assesses the contributions of categorical independent variables to variation in the mean of a continuous dependent variable.
The major progestational steroid that is secreted primarily by the CORPUS LUTEUM and the PLACENTA. Progesterone acts on the UTERUS, the MAMMARY GLANDS and the BRAIN. It is required in EMBRYO IMPLANTATION; PREGNANCY maintenance, and the development of mammary tissue for MILK production. Progesterone, converted from PREGNENOLONE, also serves as an intermediate in the biosynthesis of GONADAL STEROID HORMONES and adrenal CORTICOSTEROIDS.
Organized services for exchange of sterile needles and syringes used for injections as a potential means of reducing the transmission of infectious diseases.
A major gonadotropin secreted by the adenohypophysis (PITUITARY GLAND, ANTERIOR). Luteinizing hormone regulates steroid production by the interstitial cells of the TESTIS and the OVARY. The preovulatory LUTEINIZING HORMONE surge in females induces OVULATION, and subsequent LUTEINIZATION of the follicle. LUTEINIZING HORMONE consists of two noncovalently linked subunits, alpha and beta. Within a species, the alpha subunit is common in the three pituitary glycoprotein hormones (TSH, LH and FSH), but the beta subunit is unique and confers its biological specificity.
The measure of the level of heat of a human or animal.
Interruption of NEURAL CONDUCTION in peripheral nerves or nerve trunks by the injection of a local anesthetic agent (e.g., LIDOCAINE; PHENOL; BOTULINUM TOXINS) to manage or treat pain.
Body organ that filters blood for the secretion of URINE and that regulates ion concentrations.
An assisted reproductive technique that includes the direct handling and manipulation of oocytes and sperm to achieve fertilization in vitro.
The making of a radiograph of an object or tissue by recording on a photographic plate the radiation emitted by radioactive material within the object. (Dorland, 27th ed)
Chemical agents injected into blood vessels and lymphatic sinuses to shrink or cause localized THROMBOSIS; FIBROSIS, and obliteration of the vessels. This treatment is applied in a number of conditions such as VARICOSE VEINS; HEMORRHOIDS; GASTRIC VARICES; ESOPHAGEAL VARICES; PEPTIC ULCER HEMORRHAGE.
The 17-beta-isomer of estradiol, an aromatized C18 steroid with hydroxyl group at 3-beta- and 17-beta-position. Estradiol-17-beta is the most potent form of mammalian estrogenic steroids.
The outer covering of the body that protects it from the environment. It is composed of the DERMIS and the EPIDERMIS.
A cylindrical column of tissue that lies within the vertebral canal. It is composed of WHITE MATTER and GRAY MATTER.
Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.
Volume of biological fluid completely cleared of drug metabolites as measured in unit time. Elimination occurs as a result of metabolic processes in the kidney, liver, saliva, sweat, intestine, heart, brain, or other site.
A water-soluble extractive mixture of sulfated polysaccharides from RED ALGAE. Chief sources are the Irish moss CHONDRUS CRISPUS (Carrageen), and Gigartina stellata. It is used as a stabilizer, for suspending COCOA in chocolate manufacture, and to clarify BEVERAGES.
The domestic cat, Felis catus, of the carnivore family FELIDAE, comprising over 30 different breeds. The domestic cat is descended primarily from the wild cat of Africa and extreme southwestern Asia. Though probably present in towns in Palestine as long ago as 7000 years, actual domestication occurred in Egypt about 4000 years ago. (From Walker's Mammals of the World, 6th ed, p801)
Injections into the lymph nodes or the lymphatic system.
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
A genus of the family PARVOVIRIDAE, subfamily PARVOVIRINAE, which are dependent on a coinfection with helper adenoviruses or herpesviruses for their efficient replication. The type species is Adeno-associated virus 2.
Time schedule for administration of a drug in order to achieve optimum effectiveness and convenience.
The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.
Abnormal fluid accumulation in TISSUES or body cavities. Most cases of edema are present under the SKIN in SUBCUTANEOUS TISSUE.
Compounds capable of relieving pain without the loss of CONSCIOUSNESS.
Any of various animals that constitute the family Suidae and comprise stout-bodied, short-legged omnivorous mammals with thick skin, usually covered with coarse bristles, a rather long mobile snout, and small tail. Included are the genera Babyrousa, Phacochoerus (wart hogs), and Sus, the latter containing the domestic pig (see SUS SCROFA).
One of three principal openings in the SUBARACHNOID SPACE. They are also known as cerebellomedullary cistern, and collectively as cisterns.
Further or repeated use of equipment, instruments, devices, or materials. It includes additional use regardless of the original intent of the producer as to disposability or durability. It does not include the repeated use of fluids or solutions.
Deliberate stimulation of the host's immune response. ACTIVE IMMUNIZATION involves administration of ANTIGENS or IMMUNOLOGIC ADJUVANTS. PASSIVE IMMUNIZATION involves administration of IMMUNE SERA or LYMPHOCYTES or their extracts (e.g., transfer factor, immune RNA) or transplantation of immunocompetent cell producing tissue (thymus or bone marrow).
The ten-layered nervous tissue membrane of the eye. It is continuous with the OPTIC NERVE and receives images of external objects and transmits visual impulses to the brain. Its outer surface is in contact with the CHOROID and the inner surface with the VITREOUS BODY. The outer-most layer is pigmented, whereas the inner nine layers are transparent.
Ventral part of the DIENCEPHALON extending from the region of the OPTIC CHIASM to the caudal border of the MAMMILLARY BODIES and forming the inferior and lateral walls of the THIRD VENTRICLE.
The principal alkaloid in opium and the prototype opiate analgesic and narcotic. Morphine has widespread effects in the central nervous system and on smooth muscle.
A PREDNISOLONE derivative with similar anti-inflammatory action.
A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.
A blocking of nerve conduction to a specific area by an injection of an anesthetic agent.
The number of CELLS of a specific kind, usually measured per unit volume or area of sample.
A method of studying a drug or procedure in which both the subjects and investigators are kept unaware of who is actually getting which specific treatment.
The measurement of an organ in volume, mass, or heaviness.
The first artificially produced element and a radioactive fission product of URANIUM. Technetium has the atomic symbol Tc, atomic number 43, and atomic weight 98.91. All technetium isotopes are radioactive. Technetium 99m (m=metastable) which is the decay product of Molybdenum 99, has a half-life of about 6 hours and is used diagnostically as a radioactive imaging agent. Technetium 99 which is a decay product of technetium 99m, has a half-life of 210,000 years.
A widely used local anesthetic agent.
Either of two extremities of four-footed non-primate land animals. It usually consists of a FEMUR; TIBIA; and FIBULA; tarsals; METATARSALS; and TOES. (From Storer et al., General Zoology, 6th ed, p73)
The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.
A group of glucose polymers made by certain bacteria. Dextrans are used therapeutically as plasma volume expanders and anticoagulants. They are also commonly used in biological experimentation and in industry for a wide variety of purposes.
Mature male germ cells derived from SPERMATIDS. As spermatids move toward the lumen of the SEMINIFEROUS TUBULES, they undergo extensive structural changes including the loss of cytoplasm, condensation of CHROMATIN into the SPERM HEAD, formation of the ACROSOME cap, the SPERM MIDPIECE and the SPERM TAIL that provides motility.
A decapeptide that stimulates the synthesis and secretion of both pituitary gonadotropins, LUTEINIZING HORMONE and FOLLICLE STIMULATING HORMONE. GnRH is produced by neurons in the septum PREOPTIC AREA of the HYPOTHALAMUS and released into the pituitary portal blood, leading to stimulation of GONADOTROPHS in the ANTERIOR PITUITARY GLAND.
Small uniformly-sized spherical particles, of micrometer dimensions, frequently labeled with radioisotopes or various reagents acting as tags or markers.
Four CSF-filled (see CEREBROSPINAL FLUID) cavities within the cerebral hemispheres (LATERAL VENTRICLES), in the midline (THIRD VENTRICLE) and within the PONS and MEDULLA OBLONGATA (FOURTH VENTRICLE).
The physical activity of a human or an animal as a behavioral phenomenon.
Domesticated bovine animals of the genus Bos, usually kept on a farm or ranch and used for the production of meat or dairy products or for heavy labor.
Diabetes mellitus induced experimentally by administration of various diabetogenic agents or by PANCREATECTOMY.
The production of ANTIBODIES by proliferating and differentiated B-LYMPHOCYTES under stimulation by ANTIGENS.
A group of polycyclic compounds closely related biochemically to TERPENES. They include cholesterol, numerous hormones, precursors of certain vitamins, bile acids, alcohols (STEROLS), and certain natural drugs and poisons. Steroids have a common nucleus, a fused, reduced 17-carbon atom ring system, cyclopentanoperhydrophenanthrene. Most steroids also have two methyl groups and an aliphatic side-chain attached to the nucleus. (From Hawley's Condensed Chemical Dictionary, 11th ed)
Toxins closely associated with the living cytoplasm or cell wall of certain microorganisms, which do not readily diffuse into the culture medium, but are released upon lysis of the cells.
The rate dynamics in chemical or physical systems.
Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood.
Isotopes that exhibit radioactivity and undergo radioactive decay. (From Grant & Hackh's Chemical Dictionary, 5th ed & McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
The time it takes for a substance (drug, radioactive nuclide, or other) to lose half of its pharmacologic, physiologic, or radiologic activity.
Transplantation between animals of different species.
Production of an image when x-rays strike a fluorescent screen.
Immunoglobulin molecules having a specific amino acid sequence by virtue of which they interact only with the ANTIGEN (or a very similar shape) that induced their synthesis in cells of the lymphoid series (especially PLASMA CELLS).
Laboratory mice that have been produced from a genetically manipulated EGG or EMBRYO, MAMMALIAN.
Non-human animals, selected because of specific characteristics, for use in experimental research, teaching, or testing.
An alkylamide found in CAPSICUM that acts at TRPV CATION CHANNELS.
Toxic proteins produced from the species CLOSTRIDIUM BOTULINUM. The toxins are synthesized as a single peptide chain which is processed into a mature protein consisting of a heavy chain and light chain joined via a disulfide bond. The botulinum toxin light chain is a zinc-dependent protease which is released from the heavy chain upon ENDOCYTOSIS into PRESYNAPTIC NERVE ENDINGS. Once inside the cell the botulinum toxin light chain cleaves specific SNARE proteins which are essential for secretion of ACETYLCHOLINE by SYNAPTIC VESICLES. This inhibition of acetylcholine release results in muscular PARALYSIS.
Disease involving a spinal nerve root (see SPINAL NERVE ROOTS) which may result from compression related to INTERVERTEBRAL DISK DISPLACEMENT; SPINAL CORD INJURIES; SPINAL DISEASES; and other conditions. Clinical manifestations include radicular pain, weakness, and sensory loss referable to structures innervated by the involved nerve root.
A specific opiate antagonist that has no agonist activity. It is a competitive antagonist at mu, delta, and kappa opioid receptors.
An alkaloid ester extracted from the leaves of plants including coca. It is a local anesthetic and vasoconstrictor and is clinically used for that purpose, particularly in the eye, ear, nose, and throat. It also has powerful central nervous system effects similar to the amphetamines and is a drug of abuse. Cocaine, like amphetamines, acts by multiple mechanisms on brain catecholaminergic neurons; the mechanism of its reinforcing effects is thought to involve inhibition of dopamine uptake.
A range of methods used to reduce pain and anxiety during dental procedures.
The property of blood capillary ENDOTHELIUM that allows for the selective exchange of substances between the blood and surrounding tissues and through membranous barriers such as the BLOOD-AIR BARRIER; BLOOD-AQUEOUS BARRIER; BLOOD-BRAIN BARRIER; BLOOD-NERVE BARRIER; BLOOD-RETINAL BARRIER; and BLOOD-TESTIS BARRIER. Small lipid-soluble molecules such as carbon dioxide and oxygen move freely by diffusion. Water and water-soluble molecules cannot pass through the endothelial walls and are dependent on microscopic pores. These pores show narrow areas (TIGHT JUNCTIONS) which may limit large molecule movement.
A natural high-viscosity mucopolysaccharide with alternating beta (1-3) glucuronide and beta (1-4) glucosaminidic bonds. It is found in the UMBILICAL CORD, in VITREOUS BODY and in SYNOVIAL FLUID. A high urinary level is found in PROGERIA.
The major immunoglobulin isotype class in normal human serum. There are several isotype subclasses of IgG, for example, IgG1, IgG2A, and IgG2B.
Management, removal, and elimination of biologic, infectious, pathologic, and dental waste. The concept includes blood, mucus, tissue removed at surgery or autopsy, soiled surgical dressings, and other materials requiring special control and handling. Disposal may take place where the waste is generated or elsewhere.
Organic compounds that contain technetium as an integral part of the molecule. These compounds are often used as radionuclide imaging agents.
A polypeptide that is secreted by the adenohypophysis (PITUITARY GLAND, ANTERIOR). Growth hormone, also known as somatotropin, stimulates mitosis, cell differentiation and cell growth. Species-specific growth hormones have been synthesized.
The discharge of an OVUM from a rupturing follicle in the OVARY.
Agents and endogenous substances that antagonize or inhibit the development of new blood vessels.
Chinese herbal or plant extracts which are used as drugs to treat diseases or promote general well-being. The concept does not include synthesized compounds manufactured in China.
The transfer of mammalian embryos from an in vivo or in vitro environment to a suitable host to improve pregnancy or gestational outcome in human or animal. In human fertility treatment programs, preimplantation embryos ranging from the 4-cell stage to the blastocyst stage are transferred to the uterine cavity between 3-5 days after FERTILIZATION IN VITRO.
Serum glycoprotein produced by activated MACROPHAGES and other mammalian MONONUCLEAR LEUKOCYTES. It has necrotizing activity against tumor cell lines and increases ability to reject tumor transplants. Also known as TNF-alpha, it is only 30% homologous to TNF-beta (LYMPHOTOXIN), but they share TNF RECEPTORS.
The number of times the HEART VENTRICLES contract per unit of time, usually per minute.
They are oval or bean shaped bodies (1 - 30 mm in diameter) located along the lymphatic system.
A clear, colorless liquid rapidly absorbed from the gastrointestinal tract and distributed throughout the body. It has bactericidal activity and is used often as a topical disinfectant. It is widely used as a solvent and preservative in pharmaceutical preparations as well as serving as the primary ingredient in ALCOHOLIC BEVERAGES.
A biochemical messenger and regulator, synthesized from the essential amino acid L-TRYPTOPHAN. In humans it is found primarily in the central nervous system, gastrointestinal tract, and blood platelets. Serotonin mediates several important physiological functions including neurotransmission, gastrointestinal motility, hemostasis, and cardiovascular integrity. Multiple receptor families (RECEPTORS, SEROTONIN) explain the broad physiological actions and distribution of this biochemical mediator.
Mice homozygous for the mutant autosomal recessive gene "scid" which is located on the centromeric end of chromosome 16. These mice lack mature, functional lymphocytes and are thus highly susceptible to lethal opportunistic infections if not chronically treated with antibiotics. The lack of B- and T-cell immunity resembles severe combined immunodeficiency (SCID) syndrome in human infants. SCID mice are useful as animal models since they are receptive to implantation of a human immune system producing SCID-human (SCID-hu) hematochimeric mice.
A 51-amino acid pancreatic hormone that plays a major role in the regulation of glucose metabolism, directly by suppressing endogenous glucose production (GLYCOGENOLYSIS; GLUCONEOGENESIS) and indirectly by suppressing GLUCAGON secretion and LIPOLYSIS. Native insulin is a globular protein comprised of a zinc-coordinated hexamer. Each insulin monomer containing two chains, A (21 residues) and B (30 residues), linked by two disulfide bonds. Insulin is used as a drug to control insulin-dependent diabetes mellitus (DIABETES MELLITUS, TYPE 1).
Substances that augment, stimulate, activate, potentiate, or modulate the immune response at either the cellular or humoral level. The classical agents (Freund's adjuvant, BCG, Corynebacterium parvum, et al.) contain bacterial antigens. Some are endogenous (e.g., histamine, interferon, transfer factor, tuftsin, interleukin-1). Their mode of action is either non-specific, resulting in increased immune responsiveness to a wide variety of antigens, or antigen-specific, i.e., affecting a restricted type of immune response to a narrow group of antigens. The therapeutic efficacy of many biological response modifiers is related to their antigen-specific immunoadjuvanticity.
A major gonadotropin secreted by the adenohypophysis (PITUITARY GLAND, ANTERIOR). Follicle-stimulating hormone stimulates GAMETOGENESIS and the supporting cells such as the ovarian GRANULOSA CELLS, the testicular SERTOLI CELLS, and LEYDIG CELLS. FSH consists of two noncovalently linked subunits, alpha and beta. Within a species, the alpha subunit is common in the three pituitary glycoprotein hormones (TSH, LH, and FSH), but the beta subunit is unique and confers its biological specificity.
Use of electric potential or currents to elicit biological responses.
The active sympathomimetic hormone from the ADRENAL MEDULLA. It stimulates both the alpha- and beta- adrenergic systems, causes systemic VASOCONSTRICTION and gastrointestinal relaxation, stimulates the HEART, and dilates BRONCHI and cerebral vessels. It is used in ASTHMA and CARDIAC FAILURE and to delay absorption of local ANESTHETICS.
Compounds with activity like OPIATE ALKALOIDS, acting at OPIOID RECEPTORS. Properties include induction of ANALGESIA or NARCOSIS.
Chemicals and substances that impart color including soluble dyes and insoluble pigments. They are used in INKS; PAINTS; and as INDICATORS AND REAGENTS.
Dosage forms of a drug that act over a period of time by controlled-release processes or technology.
Procedures for the improvement or enhancement of the appearance of the visible parts of the body.
Unstable isotopes of indium that decay or disintegrate emitting radiation. In atoms with atomic weights 106-112, 113m, 114, and 116-124 are radioactive indium isotopes.
An enzyme isolated from horseradish which is able to act as an antigen. It is frequently used as a histochemical tracer for light and electron microscopy. Its antigenicity has permitted its use as a combined antigen and marker in experimental immunology.
One of the catecholamine NEUROTRANSMITTERS in the brain. It is derived from TYROSINE and is the precursor to NOREPINEPHRINE and EPINEPHRINE. Dopamine is a major transmitter in the extrapyramidal system of the brain, and important in regulating movement. A family of receptors (RECEPTORS, DOPAMINE) mediate its action.
Peripheral AFFERENT NEURONS which are sensitive to injuries or pain, usually caused by extreme thermal exposures, mechanical forces, or other noxious stimuli. Their cell bodies reside in the DORSAL ROOT GANGLIA. Their peripheral terminals (NERVE ENDINGS) innervate target tissues and transduce noxious stimuli via axons to the CENTRAL NERVOUS SYSTEM.
Artificial, single or multilaminar vesicles (made from lecithins or other lipids) that are used for the delivery of a variety of biological molecules or molecular complexes to cells, for example, drug delivery and gene transfer. They are also used to study membranes and membrane proteins.
Glucose in blood.
The period in the ESTROUS CYCLE associated with maximum sexual receptivity and fertility in non-primate female mammals.
A ubiquitous sodium salt that is commonly used to season food.
Systems for the delivery of drugs to target sites of pharmacological actions. Technologies employed include those concerning drug preparation, route of administration, site targeting, metabolism, and toxicity.

Variations in acute multifocal histoplasmic choroiditis in the primate. (1/909)

Experimental histoplasmic choroiditis was produced in primates by intracarotid injections of living H. capsulatum organisms. The severity of the choroiditis varied with inoculum size, as well as with site of injection (common carotid vs. internal carotid artery). A reproducible model of histoplasmic choroiditis in primates was produced with an internal carotid injection of 5,000 to 10,000 organisms/lb. The clinical and histopathological course of this acute choroiditis over the first 30 days is presented.  (+info)

Influence of central antitussive drugs on the cough motor pattern. (2/909)

The present study was conducted to determine the effects of administration of centrally active antitussive drugs on the cough motor pattern. Electromyograms of diaphragm and rectus abdominis muscles were recorded in anesthetized, spontaneously breathing cats. Cough was produced by mechanical stimulation of the intrathoracic trachea. Centrally acting drugs administered included codeine, morphine, dextromethorphan, baclofen, CP-99,994, and SR-48,968. Intravertebral artery administration of all drugs reduced cough number (number of coughs per stimulus trial) and rectus abdominis burst amplitude in a dose-dependent manner. Codeine, dextromethorphan, CP-99,994, SR-48,968, and baclofen had no effect on cough cycle timing (CTtot) or diaphragm amplitude during cough, even at doses that inhibited cough number by 80-90%. Morphine lengthened CTtot and inhibited diaphragm amplitude during cough, but these effects were not dose dependent. Only CP-99,994 altered the eupneic respiratory pattern. Central antitussive drugs primarily suppress cough by inhibition of expiratory motor drive and cough number. CTtot and inspiratory motor drive are relatively insensitive to the effects of these drugs. CTtot can be controlled independently from cough number.  (+info)

Effect of intracarotid prostaglandin E1 on regional cerebral blood flow in man. (3/909)

The effect of prostaglandin E1 on regional cerebral blood flow (rCBF) was studied with the intra-arterial 133Xe method in ten awake patients under local anesthesia. Measurements were taken from 16 areas of a hemisphere in seven patients, from 35 areas of a hemisphere in two patients and from 256 areas of a hemisphere in one patient. The prostaglandin was dissolved from the crystalline state without the aid of alcohol. It was given intracarotidly as a constant infusion at a rate of 5 ng per kilogram per minute for five minutes before the measurement and continued during the measurement. In every patient a mild increase in blood flow during the prostaglandin infusion was seen. The flow increase took place in all parts of the hemisphere. It averaged 11.2% (p less than 0.01). During the infusion, the skin supplied by the internal carotid artery and the conjunctiva on the infused side became red and sometimes swollen. A slight pressure was noted by most patients, but none had pain. No side effects of the infusion were noted.  (+info)

Suppression of experimental abdominal aortic aneurysms by systemic treatment with a hydroxamate-based matrix metalloproteinase inhibitor (RS 132908). (4/909)

BACKGROUND: Abdominal aortic aneurysms (AAAs) are associated with chronic inflammation, disruption of medial elastin, and increased local production of elastolytic matrix metalloproteinases (MMPs). The purpose of this study was to investigate how treatment with a hydroxamate-based MMP antagonist (RS 132908) might affect the development of experimental AAAs. METHODS: Male Wistar rats underwent intraluminal perfusion of the abdominal aorta with 50 units of porcine pancreatic elastase followed by treatment for 14 days with RS 132908 (100 mg/kg/day subcutaneously; n = 8) or with vehicle alone (n = 6). The external aortic diameter (AD) was measured in millimeters before elastase perfusion and at death, with AAA defined as an increase in AD (DeltaAD) of at least 100%. Aortic wall elastin and collagen concentrations were measured with assays for desmosine and hydroxyproline, and fixed aortic tissues were examined by light microscopy. RESULTS: AAAs developed in all vehicle-treated rats, with a mean AD (+/- SE) that increased from 1.60 +/- 0.03 mm before perfusion to 5.98 +/- 1.02 mm on day 14 (DeltaAD = 276.4 +/- 67.7%). AAAs developed in only five of eight animals (62.5%) after MMP inhibition, with a mean AD that increased from 1.56 +/- 0.05 mm to 3.59 +/- 0.34 mm (DeltaAD = 128.1 +/- 18.7%; P <.05, vs vehicle). The overall inhibition of aortic dilatation attributable to RS 132908 was 53.6 +/- 6.8%. Aortic wall desmosine fell by 85.4% in the vehicle-treated rats (1210.6 +/- 87.8 pmol/sample to 176.7 +/- 33.4 pmol/sample; P <.05) but only by 65.6% in the animals treated with RS 312908 (416.2 +/- 120.5 pmol/sample). In contrast, hydroxyproline was not significantly affected by either elastase perfusion or drug treatment. Microscopic examination revealed the preservation of pericellular elastin and a greater degree of fibrocollagenous wall thickening after MMP inhibition, with no detectable difference in the extent of inflammation. CONCLUSIONS: Systemic MMP inhibition suppresses aneurysmal dilatation in the elastase-induced rodent model of AAA. Consistent with its direct inhibitory effect on various MMPs, RS 132908 promotes the preservation of aortic elastin and appears to enhance a profibrotic response within the aortic wall. Hydroxamate-based MMP antagonists may therefore be useful in the development of pharmacologic approaches to the suppression of AAAs.  (+info)

P2 purinoceptor saturation by adenosine triphosphate impairs renal autoregulation in dogs. (5/909)

Recent studies have suggested a role for P2 purinoceptors on vascular smooth muscle cells in the mechanism of renal autoregulation. Experiments were performed in anesthetized dogs (n = 9) to examine renal blood flow (RBF) autoregulatory efficiency before and after saturation of P2 purinoceptors with acute intra-arterial administration of ATP (1 mg/kg per min). Dogs were pretreated with the nitric oxide synthase inhibitor nitro-L-arginine (NLA) (50 microg/kg per min), to avoid endothelial P2 receptor-mediated effects on nitric oxide release caused by the intra-arterial ATP infusions. NLA treatment decreased RBF (5.3+/-0.3 to 3.6+/-0.2 ml/min per g) and sodium excretion (3.6+/-0.4 to 0.9+/-0.2 ml/min per g) without producing significant changes in GFR (0.92+/-0.04 to 0.90+/-0.06 ml/min per g) or RBF autoregulatory efficiency. ATP administration to NLA-treated dogs resulted in further decreases in RBF (2.8+/-0.2 ml/min per g), GFR (0.58+/-0.05 ml/min per g), and sodium excretion (0.6+/-0.2 micromol/min per g). In addition, there was marked impairment of RBF autoregulatory efficiency during ATP infusion. The slopes of the arterial pressure-blood flow relationships at renal arterial pressures of >75 mmHg were significantly altered, from 0.003+/-0.001 to 0.2+/-0.002 ml/min per g per mmHg. Discontinuation of ATP infusion restored RBF autoregulatory efficiency. Norepinephrine (5 microg/kg per min) administration in these NLA-treated dogs decreased RBF (2.5+/-0.3 ml/min per g; n = 4) to a similar extent, compared with ATP, but did not impair RBF autoregulation. These results support the hypothesis that P2 purinoceptors may be involved in mediating autoregulatory adjustments in renal vascular resistance.  (+info)

Abnormal flow-mediated epicardial vasomotion in human coronary arteries is improved by angiotensin-converting enzyme inhibition: a potential role of bradykinin. (6/909)

OBJECTIVES: This study was performed to determine whether angiotensin converting enzyme (ACE) inhibition improves endothelium-dependent flow-mediated vasodilation in patients with atherosclerosis or its risk factors and whether this is mediated by enhanced bradykinin activity. BACKGROUND: Abnormal coronary vasomotion due to endothelial dysfunction contributes to myocardial ischemia in patients with atherosclerosis, and its reversal may have an antiischemic action. Previous studies have shown that ACE inhibition improves coronary endothelial responses to acetylcholine, but whether this is accompanied by improved responses to shear stress remains unknown. METHODS: In 19 patients with mild atherosclerosis, metabolic vasodilation was assessed during cardiac pacing. Pacing was repeated during separate intracoronary infusions of low-dose bradykinin (BK) and enalaprilat. Endothelium-dependent and -independent vasodilation was estimated with intracoronary BK and sodium nitroprusside respectively. RESULTS: Enalaprilat did not alter either resting coronary vascular tone or dilation with sodium nitroprusside, but potentiated BK-mediated dilation. Epicardial segments that constricted abnormally with pacing (-5+/-1%) dilated (3+/-2%) with pacing in the presence of enalaprilat (p = 0.002). Similarly, BK at a concentration (62.5 ng/min) that did not alter resting diameter in the constricting segments also improved the abnormal response to a 6+/-1% dilation (p < 0.001). Cardiac pacing-induced reduction in coronary vascular resistance of 27+/-4% (p < 0.001) remained unchanged after enalaprilat. CONCLUSIONS: Thus ACE inhibition: A) selectively improved endothelium-dependent but not-independent dilation, and B) abolished abnormal flow-mediated epicardial vasomotion in patients with endothelial dysfunction, in part, by increasing endogenous BK activity.  (+info)

In vivo targeting of acoustically reflective liposomes for intravascular and transvascular ultrasonic enhancement. (7/909)

OBJECTIVES: The purpose of this study was to target acoustically reflective liposomes to atherosclerotic plaques in vivo for ultrasound image enhancement. BACKGROUND: We have previously demonstrated the development of acoustically reflective liposomes that can be conjugated for site-specific acoustic enhancement. This study evaluates the ability of liposomes coupled to antibodies specific for different components of atherosclerotic plaques and thrombi to target and enhance ultrasonic images in vivo. METHODS: Liposomes were prepared with phospholipids and cholesterol using a dehydration/ rehydration method. Antibodies were thiolated for liposome conjugation with N-succinimidyl 3-(2-pyridyldithio) propionate resulting in a thioether linkage between the protein and the phospholipid. Liposomes were conjugated to antifibrinogen or anti-intercellular adhesion molecule-1 (anti-ICAM-1). In a Yucatan miniswine model, atherosclerosis was developed by crush injury of one carotid and one femoral artery and ingestion of a hypercholesterolemic diet. After full plaque development the arteries were imaged (20-MHz intravascular ultrasound catheter and 7.5-MHz transvascular linear probe) after injection of saline, unconjugated liposomes and antibody conjugated liposomes. RESULTS: Conjugated liposomes retained their acoustically reflective properties and provided ultrasonic image enhancement of their targeted structures. Liposomes conjugated to antifibrinogen attached to thrombi and fibrous portions of the atheroma, whereas liposomes conjugated to anti-ICAM-1 attached to early atheroma. CONCLUSIONS: Our data demonstrate that this novel acoustic agent can provide varying targeting with different antibodies with retention of intravascular and transvascular acoustic properties.  (+info)

Rat sarcoma model supports both "soil seed" and "mechanical" theories of metastatic spread. (8/909)

Following injection into the portal venous or vena caval systems, tumour cells are held up almost exclusively in the liver or lung respectively, and subsequent outgrowth of tumour only occurs in these organs. Following systemic arterial injection, cells are distributed, and subsequently grow, in a variety of organs. However, the adrenal gland supports tumour growth from much fewer cells than the lung, and this is partly due to the fact the rate of tumour cell loss in the initial 48 h is very high in the latter compared to the former organ.  (+info)

TY - GEN. T1 - Multimodality therapy for cerebral vasospasm after SAH. T2 - Importance of intensive care and intraarterial injection of fasudil hydrochloride. AU - Ono, Shigeki. AU - Arimitsu, S.. AU - Ogawa, T.. AU - Onoda, K.. AU - Tokunaga, K.. AU - Sugiu, Kenji. AU - Date, Isao. PY - 2008. Y1 - 2008. N2 - Until now, no absolute therapy for cerebral vasospasm (VS) after subarachnoid haemorrhage (SAH) has been established. Here we examine the efficacy of intensive multimodality therapy, contrasting with the treatment in the non-multimodality period in our institute. For 10 years, a total of 108 patients who suffered subarachnoid haemorrhage (SAH) were divided into two groups. Group A patients are from a period of time when there was no particular standardized protocol for treating SAH, i.e. 1996-2000. Group B patients include the intensive care group for treating SAH, and we employed multimodality therapy on Group B by using intraventricular urokinase (UK) injection, lumbar (LD) or cisternal ...
Assessment of clinical risk factors for haemorrhagic complications in patients undergoing intra-arterial thrombolysis for lower limb ischaemia. Retrospective reviews of consecutive patients subjected to intra-arterial thrombolysis due to lower limb ischemia at the Vascular Center, Malmö University Hospital, during a 5-year period from 2001 to 2005. Two hundred and twenty intra-arterial thrombolytic procedures were carried out in 195 patients (46% women), median age 73 years. Haemorrhagic complications were recorded in 72 procedures (33%), of which 13 were discontinued. Haemorrhage at the introducer and distant sites occurred in 53 and 32 procedures, respectively. Thrombolysis for occluded synthetic grafts was associated with higher risk of haemorrhage (P = 0.043). The platelet count was lower (P = 0.017) and the dose of alteplas higher (P = 0.041) in bleeders than in non-bleeders. Age was not associated with haemorrhage (P = 0.30). Two patients died during thrombolysis, one of them due to ...
Subcutaneous infusion of ANG II at 450, but not 150, ng·kg−1·min−1 for 14 days elevated baseline MAP compared with sham rats. We found that RSNA and pressor responses to continuous contraction and the RSNA response to intermittent contraction were significantly larger in ANGII450 rats than those in sham rats. We also found that, in ANGII450 rats, intra-arterial injection into the hindlimb circulation of tempol, a membrane-permeable SOD mimetic, reduced RSNA, arterial pressure, and HR responses to continuous contraction as well as the RSNA response to intermittent contraction. Tiron, another SOD mimetic, mirrored the effect of tempol; intra-arterial injection of Tiron into the hindlimb circulation reduced RSNA and pressor responses to continuous contraction of the hindlimb muscles of hypertensive rats. In sham and ANGII150 rats, on the other hand, tempol injected intra-arterially did not modulate RSNA and cardiovascular responses to either continuous or intermittent static contraction. ...
As well as regression assessed directly by measuring the circumference of the limb at the point of maximum tumour swelling, radiographic changes in tumour appearance occurred in the St. Bernard and Great Dane. There was resorption of periosteal new bone and a much smoother outline of the affected areas was apparent (Fig. 6). Recurrence was heralded by the proliferation of periosteal new bone. An increase in serum alkaline phosphatase values was present the day after perfusion (Fig. 7). This was not solely a feature of osteosarcomas as an increased amount of the enzyme in the blood also occurred when the limb of a dog bearing a squamous cell carcinoma was perfused. A similar effect was seen when a normal dog and a nephrecto- mised dog were perfused. An increase in serum alkaline phosphatase occurred when an osteosarcoma was treated by radiotherapy. Where therapy resulted in regression of osteosarcoma and radiography showed resorption of new bone values fell below the pre-treatment figure, rising ...
O the logistics of mounting an Aprepitant MK-0869 appropriate team and performing an angiogram may, risks in the implementation of an invasive procedure in the cerebral vasculature, and the risk of general anesthesia are used method. 2.2.1 IA thrombolysis versus no thrombolysis in patients with isch ischemic stroke and cons of IV r-tPA Note: There are indications that mode rate quality ish in patients with ischemic stroke with occlusion of the detectable cerebral artery IA thrombolysis with a erh Hten risk associated with good functional outcome, w While the results do not show or exclude s a positive effect on mortality t or beautiful Harmful. With IA thrombolysis, as r IV tPA, the long-erh Hte risk of good functional outcome at 90 days, although an increased Observed HTES risk of symptomatic ICH. 38 These data were analyzed from three studies that IA thrombolysis in patients with acute stroke phase by occlusion of the MCA and lasts 6 hours. 39 41 A subgroup of these study populations have come ...
Quality Management - Defect Injection Rate What is Defect injection Rate and how it differ from Defect review effectiveness?. 1 Answers are available for this question.
Dr Morgans Arterial Injection: The Australian Connection by Eben van Tonder 29 April 2017 INTRODUCTION Arterial pumping was one of the stepping stones to the use of multi-needle injectors universally used in meat curing plants. The initial motivation for the development of the arterial pumping system, on the one hand, was the need to preserve meat…
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TY - JOUR. T1 - FSH and LH Response in the Rat After Intravenous, Intracarotid or Subcutaneous Administration of LH-RH. AU - Greeley, George H.. AU - Allen, M. B.. AU - Mahesh, V. B.. PY - 1974/12. Y1 - 1974/12. N2 - Using permanent stalk sectioned ovariectomized rats and 4 day cyclic rats on the day of estrus, the effect of either subcutaneous or acute intravenous intracarotid luteinizing hormone releasing hormone (LH RH) was examined. After a subcutaneous injection of LH RH both follicle stimulating hormone (FSH) and LH release occurred, whereas only LH levels increased after an intravenous or intraarterial injection. These results suggest that prolonged exposure of the pituitary to LH RH is necessary for FSH discharge, or that LH RH may undergo metabolic modifications resulting in greater FSH releasing activity.. AB - Using permanent stalk sectioned ovariectomized rats and 4 day cyclic rats on the day of estrus, the effect of either subcutaneous or acute intravenous intracarotid luteinizing ...
NEW YORK - Neurosurgeons from NewYork-Presbyterian Hospital/Weill Cornell Medical Center performed the worlds first intra-arterial cerebral infusion of Avastin (bevacizumab) directly into a patients malignant brain tumor. This novel intra-arterial (IA) technique may expose the cancer to higher doses of the drug therapy, while possibly sparing the patient common side effects of receiving the drug intravenously (IV) or throughout their body.. The investigative procedure - called super selective intra-arterial cerebral infusion of Avastin - has been successfully performed on five patients with promising results. Details of the first case are scheduled for publication in the next issue of Journal of Experimental Therapeutics and Oncology. The researchers are currently enrolling patients for the Phase I study, which will test the safety and tolerability of this new method of drug delivery. If proven successful, NewYork-Presbyterian/Weill Cornell physician-scientists believe that this promising ...
Gracos Harrier electronic chemical injection rate controllers monitor and control automated chemical injection systems. Harrier saves you time and money.
A pressing need in the management of the chronic occlusive arterial diseases is an effective oral vasodilator to control the common presenting complaint of intermittent claudication. Many drugs and procedures have been tried but found wanting, some because of undesirable side-effects and difficulty in administration, others because they improved circulation in skin areas and did little to relieve muscle ischemia.. Some years ago, while investigating the effects of the intra-arterial injection of adrenalin upon blood flow in the forearm,1 we were struck by the marked dilation it produced in muscle even in minute concentration. These doses proved to be constrictor, ...
Intra-arterial therapy (IAT) for acute ischemic stroke has undergone great evolution during the past decade. While intra-venous therapy remains the standard of care for eligible patients, there are those patients in whom IV tPA is contraindicated, or
Withdrawal of life-sustaining therapies produced a decline in brain tissue partial pressure of oxygen (pti O2 ) and circulatory arrest. Silencing of spontaneous electrical activity developed simultaneously across regional electrode arrays in eight patients. This silencing, termed nonspreading depression, developed during the steep falling phase of pti O2 (intraparenchymal sensor, n=6) at 11 (7, 14) mmHg. Terminal spreading depolarizations started to propagate between electrodes 3.9 (2.6, 6.3) min after onset of the final drop in perfusion and 13 to 266s after nonspreading depression. In one patient, terminal spreading depolarization induced the initial electrocerebral silence in a spreading depression pattern; circulatory arrest developed thereafter.. INTERPRETATION ...
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Therefore, the injection rate in conjunction with the survival time can produce large differences, and in the worst cases, cell populations that are
With increasing demands from regulators for operators to adhere to stringent limits of odourisation, there are more demands for odourant systems that are required to meet a huge range of injection rates and in locations that previously were not considered as practical sites for odourant systems.. Haldatec have for years provided systems ranging from major pipeline installations, to installations on suburban blocks and small industrial customers, with the associated demands for system sophistication to economical simplicity, whilst maintaining high accuracy of odourant levels.. We do not have standard packages. Each one is designed and built to cater for individual needs - we understand one size does not fit all.. ...
TY - JOUR. T1 - Novel therapy for liver cancer. T2 - Direct intraarterial injection of a potent inhibitor of ATP production. AU - Geschwind, Jean Francois H.. AU - Ko, Young H.. AU - Torbenson, Michael S.. AU - Magee, Carolyn. AU - Pedersen, Peter L.. N1 - Copyright: Copyright 2008 Elsevier B.V., All rights reserved.. PY - 2002/7/15. Y1 - 2002/7/15. N2 - Most types of cancer are difficult to eradicate and some, like liver carcinomas, are almost always fatal. Significantly, we report here that direct intraarterial delivery of 3-bromopyruvate (3-BrPA), a potent inhibitor of cell ATP production, to liver-implanted rabbit tumors, inflicts a rapid, lethal blow to most cancer cells therein. Moreover, systemic delivery of 3-BrPA suppresses metastatic tumors that arise in the lungs. In both cases, there is no apparent harm to other organs or to the animals. Thus, intraarterial delivery of agents like 3-BrPA directly to the site of the primary tumor, followed by systemic delivery only when necessary, ...
AIMS--To record the histopathological findings associated with intra-arterial injection of Temazepam gel by nine drug misusers. METHODS--Standard histological examination and immunocytochemistry for endothelial markers (factor VIII related antigen, Ulex europaeus lectin) were carried out. RESULTS--Intra-arterial injection of Temazepam gel may cause severe vascular injury and lead to amputation of fingers or limbs. Histological changes include myocyte necrosis, interstitial oedema, extensive arterial, venous, and capillary thrombosis, and sometimes vasculitis, endothelial swelling, and denudation. CONCLUSIONS--Inadvertent injection of Temazepam gel into arteries may cause catastrophic ischaemic damage, possibly as a result of toxic effects on endothelial cells.. ...
If given by the intra-arterial route, the immediate effect of the hydrogenated alkaloids of ergot is unpredictable. Vasodilation is obtained in some patients only. However, it was found that in those cases who do not react, the vessels respond more easily to the release of sympathetic tone, proving that, nevertheless, the drug has had an (potential) effect, probably on the neurovascular apparatus. This effect could be demonstrated for many hours and is, therefore, of considerable therapeutic interest. Even with the higher local concentrations possible by the intra-arterial route, the hydrogenated alkaloids of ergot still did not exhibit any adrenolytic action on the peripheral blood vessels in man.. ...
TY - JOUR. T1 - EEG and brain death determination in children. AU - Alvarez, L. A.. AU - Moshé, S. L.. AU - Belman, A. L.. AU - Maytal, J.. AU - Resnick, T. J.. AU - Keilson, M.. PY - 1988/2. Y1 - 1988/2. N2 - In a retrospective study involving several medical centers we identified 52 patients under age 5 yeare who met the adult clinical criteria for brain death and had at least one EEG with electrocerebral silence. Of the 52 patients, 31 died spontaneously and 21 were disconnected from the respirator. Repeat EEGs were obtained in 28 patients, and in all electrocerebral silence persisted. The study suggests that clinical criteria similar to those used for adults in the determination of brain death can also be applied to children above age 3 months and that a single EEG with electrocerebral silence is sufficient to confirm brain death in this age group.. AB - In a retrospective study involving several medical centers we identified 52 patients under age 5 yeare who met the adult clinical criteria ...
This narrative review discusses the incidence, risk factors, mechanisms of injury, complications, and treatment regimens for accidental intra-arterial inje
IVTEAM has established itself as a core global resource for infusion and vascular access practitioners. Each day 6K users have access thousands of pages of easy to access relevant intravenous news and updates. IVTEAM offers its visitors a premier service that has no financial or subscriber based restrictions. The editorial stance of IVTEAM is to ensure no editorial restrictions exist; content remains unbiased and independent.. It is crucial that IVTEAM stays up-to-date and offers visitors regular, current updates. Each day news feeds are analysed, websites searched and various additional sources of information visited. This results in large amounts of data being sifted through for relevant information every day. Only a small amount of data is relevant to IV practice and makes it onto IVTEAM. ...
Catheterization-related strokes are rare (0.07% to 0.38%)1,2 and almost always are of embolic origin. Emboli can originate from dislodgement of material from plaque rupture, calcium from aortic cusps, or thrombus formation in the catheters or on the guides.3-5 Furthermore, the apposition of thrombus to the embolic material may be an important component of cerebral artery occlusion. Computed tomography scan and magnetic resonance imaging seem to be unnecessary because they do not add anything to the diagnosis and treatment. An immediate carotid angiogram to assess cerebral artery occlusion appears to be the best and least time-consuming approach. Hemorrhagic stroke can be recognized by extravasation or late persistence of contrast. Recent studies comparing intra-arterial and intravenous thrombolytic therapy in thromboembolic stroke have shown a higher rate of revascularization with intra-arterial thrombolysis.6,7 Previous trials have shown the safety and efficacy of intra-arterial thrombolysis ...
The intracarotid injection of hypertonic saline in the rabbit induces a brief drop in arterial pressure followed by a somewhat longer pressor phase. The osmoreceptors activating these changes are related to the hindbrain and are not the elements responsible for releasing neurohypophysial hormones. The pressure changes are not prevented by vagotomy, deafferentation of the carotid body and sinus, adrenalectomy, or parasympathetic blockade. The blood pressure effects are interpreted as resulting from sequential inhibition and stimulation of medullary vasomotor centers by the hypertonic solutions.. ...
A method of operating a H2-O2 fuel cell fueled by hydrogen-rich fuel stream containing CO. The CO content is reduced to acceptable levels by injecting oxygen into the fuel gas stream. The amount of oxygen injected is controlled in relation to the CO content of the fuel gas, by a control strategy that involves (a) determining the CO content of the fuel stream at a first injection rate, (b) increasing the O2 injection rate, (c) determining the CO content of the stream at the higher injection rate, (d) further increasing the O2 injection rate if the second measured CO content is lower than the first measured CO content or reducing the O2 injection rate if the second measured CO content is greater than the first measured CO content, and (e) repeating steps a-d as needed to optimize CO consumption and minimize H2 consumption.
TY - JOUR. T1 - Functional volumetric MRI in assessing treatment response to intra-arterial therapy of primary and secondary liver tumors. AU - Corona Villalobos, Celia. AU - Kamel, Ihab R. PY - 2014. Y1 - 2014. N2 - The assessment of tumor response after intra-arterial therapy (IAT) is useful to determine treatment success, to guide future treatments, and to predict patient outcome. Changes in tumor size in the axial plane after transarterial therapies might be delayed with the traditional criteria, whereas cellular tumor changes can be detected earlier by functional metrics such as vascular enhancement and cellular integrity in the entire tumor volume. Magnetic resonance imaging has become an important tool in the evaluation of early tumor response with the introduction of new techniques, such as diffusion-weighted imaging and apparent diffusion coefficient maps, and the development of advanced software to quantify vascular enhancement after IATs. This review discusses the role of treatment ...
PURPOSE To evaluate the effectiveness of intraarterial infusion chemotherapy (IAC) with mitoxantrone hydrochloride in patients with previously treated, locally recurrent breast cancer. MATERIALS AND METHODS Thirty-nine women (aged 31-82 years) with recurrent breast cancer underwent superselective IAC (25 mg/m2 mitoxantrone hydrochloride every 24 hours) through the subclavian artery branches after heparin administration. The extent of tumor perfusion was monitored with computed tomography during the intraarterial administration of contrast medium. IAC was repeated one to nine times. Patients had previously undergone radiation therapy (n = 39), surgery (n = 20), or systemic chemotherapy (n = 23). RESULTS The overall response rate was 77% (n = 30). Eight patients had complete remission. Progression occurred in three patients. Remission was observed in cases of lymph node involvement (n = 9). Seven patients are still undergoing treatment. Side effects were usually moderate. Nine patients died of
The National Institute of Neurological Disorders and Stroke trial of recombinant tissue plasminogen activator has been considered a landmark study in the acute treatment of ischemic stroke. Unfortunately, only a small percentage of all ischemic stroke patients presents to the hospital in time to receive the drug. Moreover, the recannalization rate of a major artery occlusion, such as the proximal middle cerebral artery or top of the internal carotid artery occlusion, after intravenous (IV) thrombolytic therapy has been disappointingly low. Since the Food and Drug Administrations approval of IV plasminogen activator, there have been numerous randomized clinical trials investigating the safety and efficacy of different thrombolytics administered in various time frames. In addition to the IV administration, efforts have been made in order to study the radiographic as well as clinical effects of intra-arterial (IA) thrombolysis. The combination of IV and IA thrombolysis has been studied. For ...
The isolated canine spleen was perfused at constant flow with continuous recording of splenic arterial perfusion pressure (SAPP) and spleen weight. Intra-arterial injections of the thromboxane A2 (TXA2) mimetic U46619 caused dose-related increases in splenic arterial perfusion pressure (SAPP) of short duration (ED50 0.31 nmol). There were very small changes in spleen weight accompanying any of the vasoconstrictor responses to U46619. The stable analogue of prostacyclin, iloprost, caused dose-dependent reductions in SAPP (ED50 1.3 nmol) indicating vasodilatation. There were no changes in spleen weight to any doses of iloprost indicating a lack of action on capsular smooth muscle. Similarly, the nitric oxide (NO) mimetic sodium nitroprusside caused dose-related reductions in SAPP of short duration (ED50 5.8 nmol). No changes in spleen weight accompanied splenic vasodilator responses to any dose of sodium nitroprusside (SNP). The results indicate the potential actions and intrinsic potency of three ...
ADMINISTRATION AND DOSAGE The advisable dosage is one mg/lb (one mL/a hundred lbs) of physique bodyweight when every day. Treatment is administered by intravenous injection and could be recurring for up to 5 days. Onset of activity is within two hours with peak response by 12 hours. CONTRAINDICATIONS There arent any recognized contraindications to this drug when utilised as directed. Intra-arterial injection really should be prevented. Will not use in a very horse if its got previously demonstrated hypersensitivity to ketoprofen. CAUTION This item should not be Utilized in breeding animals Considering that the effects of KETOFEN on fertility, pregnancy or fetal wellbeing in horses havent been established. Safeguards Scientific studies to ascertain action of KETOFEN when administered concomitantly with other medicine havent been carried out. Drug compatibility must be monitored carefully in people necessitating adjunctive therapy. WARNING Not for use in horses supposed for food. SIDE EFFECTS ...
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2015 (English)In: Vascular and Endovascular Controversies Update / [ed] Greenhalgh R, London: BIBA Publishing , 2015, 315-320 p.Chapter in book (Other academic) ...
Intra-arterial (IA) chemotherapy improves the therapeutic index of administered agents. This conference has addressed this issue in great depth, and I would like to comment only on the agents...
Catheter-directed delivery has revolutionised modern medicine, with applications for treating cancers, infections, stenotic disorders, clots - even diab
TY - JOUR. T1 - Ultrasound-guided percutaneous thrombin injection for post-catheterization pseudoaneurysm. AU - Kuma, Sosei. AU - Morisaki, Koichi. AU - Kodama, Akio. AU - Guntani, Atsushi. AU - Fukunaga, Ryota. AU - Soga, Yoshimitsu. AU - Shirai, Shinichi. AU - Ishida, Masaru. AU - Okazaki, Jin. AU - Mii, Shinsuke. PY - 2015/5/11. Y1 - 2015/5/11. N2 - Background: The efficacy and safety of ultrasound-guided thrombin injection (UGTI) for the treatment of postcatheterization femoral and brachial artery pseudoaneurysms (PSA) is unclear in Japan. Methods and Results: A retrospective study of 32 consecutive patients undergoing percutaneous UGTI of postcatheterization PSA between February 2011 and February 2014 was performed. There were 23 femoral PSA and 9 brachial PSA treated with UGTI. The prevalence of CAD and smoking history were higher in the brachial PSA patients, but there were no statistically significant differences in other patient demographic factors or in the preprocedural antiplatelet ...
Background: This study aimed to investigate the safety and tolerability of the intra-arterial administration of autologous bone marrow-derived mesenchymal stem cells (BM-MSCs) in patients with multiple system atrophy (MSA)-cerebellar type (MSA-C).Methods:|/stron...
OBJECTIVE: To determine the value of selective intra-arterial calcium stimulation with hepatic venous sampling using serum insulin and C-peptide gradients for the preoperative localization of insulinomas. MATERIALS AND METHODS: Seven consecutive pati
18 Background: Hemorrhagic transformation is a major complication of intra-arterial (IA) thrombolytic therapy. Delineation of significant predictors of intracerebral hemorrhage (ICH) following thrombolysis would be useful to guide patient selection for IA treatment. Methods: Data were collected on consecutive patients with acute cerebral ischemia treated with IA thrombolysis over an 8 year period at UCLA Medical Center. Patients received either pure IA thrombolytics (tPA or urokinase) or combined intravenous/intra-arterial (IV/IA) tPA. Using univariate and multivariate analyses, 58 variables were examined as potential predictors of ICH. Results: A total of 89 patients were treated, 77 anterior circulation, 12 posterior circulation. Median baseline NIHSS score was 16. 26 patients received IA tPA only, 22 IV/IA tPA, and 41 IA urokinase only. Asymptomatic ICH occurred in 29 patients (33%), minor symptomatic ICH in 10 (11%), and major symptomatic ICH in 6 (7%). Of the 45 patients with M1 or M2 MCA ...
Dr. Kaesmacher reports: Until now, the significance of administering intra-arterial thrombolytic medicines following mechanical thrombectomy has not been clarified.. Accordingly, the recommendation of the American Stroke Association regarding its use has been cautious. The published results of the study thus constitute an important component in defining the future significance of the intra-arterial administration of fibrinolytics.. Intra-arterial dissolution of blood clots has potential for improvement. The patients analyzed in the study (doi: 10/1001/jamaneurol.2019.4192) published in JAMA Neurology showed residual peripheral occlusions subsequent to mechanical thrombectomy, which led to an almost complete rather than a complete reperfusion.. The authors of the study were able to show that these peripheral occlusions could often be dissolved with the intra-arterial administration of a special thrombolytic (Urokinase) and thereby further improve reperfusion.. This was also reflected in a ...
Prostaglandin E1 (PGE1) is a vasodilator that inhibits platelet aggregation. Its use has been effective intra-arterially in treating ischemic peripheral vascular disease. Its potentially beneficial effect in treating frostbite injuries has not been studied and prompted this investigation. A standard frostbite injury was induced by immersing the hindlimbs of New Zealand white rabbits in an ethylene glycol bath maintained at -15 C. Forty animals were separated into eight equal groups (N = 5). Groups I through V were allowed to slowly rewarm at room temperature (21 - 22 C), while Groups VI through VIII underwent rapid rewarming in a water bath at 42 ± 1 C. Groups I and VI received no further treatment. Groups II and VII received intra-arterial bolus injections of saline. Group III received intra-arterial bolus injections of reserpine (2.5 x 10-3 mg/kg-1). Group IV received intra-arterial bolus injections of PGE1 (10-1 μg/kg-1). Groups V and VIII received 3-hour intra-arterial infusions of PGE1 ...
Mechanical thrombectomy aims to achieve rapid clot removal by means of different devices instead of the slow pharmacological disintegration of the embolic material after intra-arterial injection. The recent introduction of stent-based thrombectomy has revolutionized the endovascular revascularization of acute large vessel occlusion, with marked improvement in both time and rate of recanalization.15 ,19-22 Until stent-retrievers were introduced into common practice, endovascular management of tandem occlusions was complex, only partially effective, hazardous, and time-consuming.10-13. In this report, we present a case series of 24 patients with acute anterior circulation tandem occlusions treated exclusively with proximal stent-assisted angioplasty immediately followed by stent-based thrombectomy. Our preliminary data on this group of 24 patients suggest that angioplasty and stenting of the proximal occlusion followed by intracranial intervention may be feasible, efficacious, and safe, and may ...
The involvement of a thromboxane (TX) A2-like substance in the decrease of mucosal blood flow (MBF) and occurrence of gastric erosions in rats under water-immersion stress was examined. MBF was estimated by aminopyrine clearance. Stress increased acid output without a parallel increase in MBF and caused erosions. OKY-046, an inhibitor of TXA2 synthesis, and ONO-11120, an antagonist of TXA2 receptors, increased MBF during stress in parallel with an increase in acid output, and erosions did not form. In another experiment, the effects of a TXA2-like substance on MBF during vagal stimulation were examined. Although vagal stimulation alone increased acid output, there were no erosions in the stomach, probably because MBF was increased in parallel with acid output. Intra-arterial administration of a TXA2-like substance formed by the metabolism of arachidonic acid in the blood reduced MBF during vagal stimulation. Intra-arterial administration of ONO-11113, an agonist of TXA2 receptors, also reduced ...
In this study, we used a laboratory X-ray system with a 1 μm microfocus X-ray source, and investigated the hindlimb peripheral vascular function in anesthetized mice. The hindlimb vessels, from large conduit femoral artery (diameters over 200 μm) to small artery-arterioles (diameters less than 100 μm), were clearly visualized with a conventional angiographic method, using bolus intra-arterial injection of iodinated contrast agent during each image acquisition (Figs. 1 and 2). In the last decade, angiograms of intra-organ microvasculature in the rodents heart [14,15], lungs [16,17], and brain [19-21] were successfully obtained by using in-vivo microangiography with synchrotron radiation as an X-ray source [25]. Some of the earlier studies using laboratory X-ray imaging sources also demonstrated the brain microvasculature in small animals [18,26]. These in vivo microangiographic techniques allow us to obtain an angiogram with acceptable spatial and time resolution for dynamic, real-time ...
This study investigates whether plasma extracts previously demonstrated to have natriuretic and antinatriferic activity have effects on vascular reactivity of rat cremaster arterioles. Plasma from hydropenic and saline-loaded dogs was subjected to Diafiltration, and eluted on a strong cation exchange column (SCX). The effects of intraarterial injections of various column fractions on constrictor responses to repeated injections of 33.3 ng of norepinephrine (NE) were used to indicate changes in vascular responsiveness in third order cremaster arterioles. SCX fraction I (void volume) from saline-loaded dogs (FI-S) caused an increase in constrictor response to NE of 101%. Increased vascular responsiveness peaked at 40 minutes and remained significantly elevated (p less than 0.05) for 130 minutes. Fraction I from plasma of hydropenic dogs (FI-H) and fraction III from plasma of saline-loaded dogs (FIII-S) did not increase vascular responsiveness to NE. FI-S shifted the dose response curves for NE, ...
INDICATIONS: Optison is indicated for use in patients with suboptimal echocardiograms to opacify the left ventricle and to improve the delineation of the left ventricular endocardial borders. CONTRAINDICATIONS: Do not administer Optison to patients with known or suspected: (1) Right-to-left, bidirectional, or transient right-to-left cardiac shunts or (2) Hypersensitivity to perflutren, blood, blood products, or albumin. Do not administer Optison by intra-arterial injection. WARNINGS Anaphylactoid Reactions: In postmarketing use, uncommon but serious anaphylactoid reactions were observed during or shortly following perflutren-containing microsphere administration, including in patients with no prior exposure to perflutren-containing microsphere products. High Ultrasound Mechanical Index: High ultrasound mechanical index values may cause microsphere cavitation or rupture and lead to ventricular arrhythmias. Additionally, end-systolic triggering with high mechanical indices has been reported to ...
Looking for intrarenal arteries? Find out information about intrarenal arteries. blood vessel that conveys blood away from the heart heart, muscular organ that pumps blood to all parts of the body. The rhythmic beating of the heart is a... Explanation of intrarenal arteries
Ondansetron and promethazine are used to prevent nausea and vomiting. should be administered only via a large-bore vein, preferably via a central venous access site, not by veins in the hand or wrist. Children over 10 years and adults (including elderly) 25 mg as a single dose*. Call your doctor if your symptoms do not improve, or if they get worse while using promethazine. How long is Phenergan good for? The dose of Phenergan for the active therapy of nausea and vomiting in children or adults is 25 mg. Irritation and damage can result from perivascular extravasation, unintentional intra-arterial injection, and intraneuronal or perineuronal infiltration (see WARNINGS - Severe Tissue Injury, Including Gangrene). Phenergan is a phenothiazine antihistamine that functions in the physical body by protecting against the launch of histamine, known for inducing sneezing, itchy eyes, watery eyes, hives, skin breakout and other ones. See more on 7.9/10 Phenergan Dosage Guide - ...
Acute central nervous system (CNS) toxicity and immune-related side effects are increasingly recognized with the use of monoclonal antibodies for cancer therapy. Here, we report a patient who developed of acute-onset encephalopathy and coma, which began shortly after administration of panitumumab for the treatment of metastatic colorectal cancer. Echocardiography revealed that the drug had been infused into the left cardiac ventricle via a dislocated central venous line. Diffusion-weighted magnetic resonance imaging disclosed multiple cortical hyperintensities, which were preferentially located in the frontal lobes. While the neurological condition improved within a few days, the patient died four weeks later. It seems likely that the administration of the antibody via the intra-arterial route contributed to the development of this condition. Toxic encephalopathy may be a hitherto unrecognized complication of panitumumab treatment and should be taken into consideration in patients developing CNS
On the fourth day of both treatment periods, forearm blood flow (FBF) was assessed by venous occlusion strain gauge plethysmography. A time schedule of these flow assessments is provided in Figure 2. All experiments were performed in the morning after an overnight fast in a temperature-controlled room (23°C), with the subjects in a supine position. If needed, dose adjustments of hypoglycemic agents were recommended during the evening and early morning before the assessments. Capillary glucose levels were monitored. The brachial artery of the nondominant arm was cannulated with a 27-gauge needle (kindly supplied by B. Braun Medical BV, Oss, the Netherlands) for intraarterial administration of saline, acetylcholine (Miochol, Thea Pharma NV, Zoetermeer, the Netherlands), and nitroglycerine (Nitropohl, Pohl-Boskamp, Hoofddorp, the Netherlands). FBF was assessed during the successive administration of 3 increasing doses of acetylcholine (0.5, 2, and 8 μg/min per dL of forearm tissue) and ...
The authors compared the three-dimensional Fourier transform (3DFT) time-of-flight magnetic resonance (MR) angiograms in 38 patients initially studied with selective intraarterial digital subtraction angiography (DSA) for suspected arteriosclerotic disease of the carotid bifurcation. MR angiograms w …
学术讲座预告. 报告一. 题目: 关于保险资金运用的几点思考. 报告人:魏丽 教授 (中国人民大学财政金融学院). 报告内容摘要: 通过对保险资金投资收益率、保险资金运用的政策和市场环境的分析,探讨险资举牌和祸起万能险等近年保险资金运用的热点和疑点问题。通过对保险投资现象和成因的剖析,对万能险、保险资金运用及对资本市场发展的影响提出几点思考。. 报告二. 题目: Optimal financing of a firm: a hybrid strategy. 报告人:孟辉 研究员 (中央财经大学中国精算研究院). 报告内容摘要: This paper investigates an optimal investment of capital into a large company or institution, in the form of cash. We first bring forward the decision maker can choose the types of injection capital including regular injection and impulse injection. The decision maker has the option to decide the capital injection rate and capital injection time ...
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Intra-arterial lidocaine versus saline to reduce peri-procedural discomfort in patients undergoing percutaneous trans-radial or trans-ulnar coronary procedures.
Available for download at the bottom of this page: Intra-arterial poster - This poster contains some of the key information in this...
Quasiparticle (qp) poisoning is a major issue that impairs the operation of various superconducting devices. Even though these devices are often operated at temperatures well below the critical point where the number density of excitations is expected to be exponentially suppressed, their bare operation and stray microwave radiation excite the non-equilibrium qps. Here we use voltage-biased superconducting junctions to demonstrate and quantify qp extraction in the turnstile operation of a superconductor-insulator-normal metal-insulator-superconductor single-electron transistor. In this operation regime, excitations are injected into the superconducting leads at a rate proportional to the driving frequency. We reach a reduction of density by an order of magnitude even for the highest injection rate of 2.4 × 108 qps per second when extraction is turned on.. ...
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TY - JOUR. T1 - ANGIOGRAFIA DIGITAL INTRAARTERIAL EN LA EVALUACION DE LA ISQUEMIA CEREBRAL TRANSITORIA. AU - Mendez, G.. AU - Nunez, D.. AU - Yrizarry, J. M.. PY - 1984/12/1. Y1 - 1984/12/1. UR - UR - M3 - Article. AN - SCOPUS:0021672932. VL - 9. SP - 201. EP - 205. JO - Revista interamericana de radiologia. JF - Revista interamericana de radiologia. SN - 0034-9704. IS - 4. ER - ...
The development of analytical techniques for on-site real-time data analysis has received attention in recent years in terms of their potential utilization for industrial and environmental requirements. The sample pretreatment stage is generally the weak link of the entire analytical procedure. Therefore, efforts are directed towards the development of efficient and safe automated sample pretreatm
"Localized retiform purpura after accidental intra-arterial injection of polidocanol". Acta Dermatol Venereol. 85 (4): 372-373. ... and intraarticular injections. Livedoid dermatitis has been reported to occur with many different drug injections, including: ... The reaction is associated with a range of both injection sites and drugs. It was first reported by Freudenthal in 1924 ... Injection site reactions List of cutaneous conditions James, William; Berger, Timothy; Elston, Dirk (2005). Andrews' Diseases ...
Complications associated with brachial plexus block include intra-arterial or intravenous injection, which can lead to local ... Injection close to the point of elicitation of such a paresthesia may result in a good block. A peripheral nerve stimulator ... Subcutaneous injection of local anesthetic over the medial aspect of the arm in the axilla helps patients tolerate an arm ... To achieve an optimal block, the tip of the needle should be close to the nerves of the plexus during the injection of local ...
It has likewise been recommended for treatment of inadvertent intra-arterial injections (10 ml of 1% procaine), as it helps ... It is used primarily to reduce the pain of intramuscular injection of penicillin, and it is also used in dentistry. Owing to ... A 1% procaine injection has been recommended for the treatment of extravasation complications associated with venipuncture ( ...
Intra-arterial injections of SRTX-b causes a dose- dependent increase in perfusion pressure at doses ranging from 30 to 300 ... The same study also found marked disturbances in gas exchange and acid-base equilibrium after injection with the toxin. Acute ... The time required for the recovery of perfusion pressure to baselines after a bolus injection of 300 pmol SRTX-b is shorter ... abundant and frothy fluid was found in tracheal cannulas after sarafotoxin injection. ...
... accidental intra-arterial or intravenous injection, difficulty swallowing, vocal cord paralysis, epidural spread of local ... Injection is often given near the Chassaignac's Tubercle (anterior tubercle of transverse process of C6) due to this being an ... Injection of local anesthetics near the stellate ganglion can sometimes mitigate the symptoms of sympathetically mediated pain ...
It has likewise been recommended for treatment of inadvertent intra-arterial injections (10 ml of 1% procaine), as it helps ... Allergic reactions are in fact quite rare, estimated to have an incidence of 1 per 500,000 injections. About one in 3000 white ... A 1% procaine injection has been recommended for the treatment of extravasation complications associated with venipuncture, ... and is also used to reduce the pain of intramuscular injection of penicillin. Owing to the ubiquity of the trade name Novocain ...
... regarding intra-arterial injection. After a few further changes to the labeling not related to intra-arterial injection, the ... The most notable activity occurred in 1987, when the FDA suggested different warnings about the risk of arterial exposure, and ...
Intra-arterial injection (especially in drug addicts) Ehlers-Danlos syndrome - connective tissue disorder, often with many ...
... injections, intra-arterial MeSH E05.300.530.380 - injections, intra-articular MeSH E05.300.530.430 - injections, intralesional ... injections, subcutaneous MeSH E05.300.530.620.410 - injections, intradermal MeSH E05.300.530.620.570 - injections, jet MeSH ... injections, intraventricular MeSH E05.300.530.580 - injections, spinal MeSH E05.300.530.580.300 - injections, epidural MeSH ... injections, intramuscular MeSH E05.300.530.490 - injections, intraperitoneal MeSH E05.300.530.540 - injections, intravenous ...
Inadvertent intra-arterial injection can also result in endarteritis and thrombosis, with ultimately similar consequences. ... Arterial damage - Arterial pseudoaneurysms may form at injection sites, which can rupture, potentially resulting in hemorrhage ... including unclean or unsafe injection practices and repeated injections at the same site. Injection drug users that fail to ... Drug injection is also commonly a component in HIV-related syndemics. Fragments from injection of pills are known to clog the ...
As of 2012[update], clinical trials were underway to test an intra-arterial technique for delivering the drug directly to brain ... The injection of 1.25-2.5 mg of bevacizumab into the vitreous cavity has been performed without significant intraocular ... "Intra-arterial delivery of bevacizumab after blood-brain barrier disruption for the treatment of recurrent glioblastoma: ... "Bevacizumab Injection: MedlinePlus Drug Information". 28 February 2014. Archived from the original on 25 March ...
... intra-arterial mechanical thrombectomy is more effective than traditional treatment (intravenous thrombolytic injection). The ... to the image after contrast media injection, to provide an image where only brain vessels are displayed, with great improvement ... "A Randomized Trial of Intraarterial Treatment for Acute Ischemic Stroke". New England Journal of Medicine. 372 (1): 11-20. doi: ... Swedish physician Sven Seldinger introduced the technique of arterial and venous catheterization still in practice, dubbed the ...
... treatment or intra-arterial cerebral flushing, a combination of digital subtraction angiography (DSA) and heparin injection for ...
"Intra-arterial chemotherapy for the management of retinoblastoma: four-year experience". Arch Ophthalmol. 129 (6): 732-7. doi: ... "Evomela (melphalan) for Injection, for Intravenous Use. Full Prescribing Information". Spectrum Pharmaceuticals, Inc. Irvine, ...
intra-arterial (into an artery), e.g. vasodilator drugs in the treatment of vasospasm and thrombolytic drugs for treatment of ... intra-articular, into a joint space. It is generally performed by joint injection. It is mainly used for symptomatic relief in ... intracavernous injection, an injection into the base of the penis. *intradermal, (into the skin itself) is used for skin ... "injection". Cambridge dictionary. Retrieved 2017-07-30.. *^ "MDMA (ecstasy) metabolites and neurotoxicity: No occurrence of ...
Intra-articular, into a joint space. It is generally performed by joint injection. It is mainly used for symptomatic relief in ... Intra-arterial (into an artery), e.g. vasodilator drugs in the treatment of vasospasm and thrombolytic drugs for treatment of ... Intracavernous injection, an injection into the base of the penis. Intradermal, (into the skin itself) is used for skin testing ... In addition to injection, it is also possible to slowly infuse fluids subcutaneously in the form of hypodermoclysis. ...
Intra-arterial (into an artery), e.g. vasodilator drugs in the treatment of vasospasm and thrombolytic drugs for treatment of ... Intra-articular, into a joint space. It is generally performed by joint injection. It is mainly used for symptomatic relief in ... Intracavernous injection, an injection into the base of the penis.. *Intradermal, (into the skin itself) is used for skin ... "injection". Cambridge dictionary. Archived from the original on 2017-07-30. Retrieved 2017-07-30.. ...
Higashi S, Shimizu M, Nakashima T, Iwata K, Uchiyama F, Tateno S, Tamura S, Setoguchi T (March 1995). "Arterial-injection ... Dodds HM, Walpole ET, Rivory LP, Strong RW, Pond SM (October 1996). "Disposition of epirubicin after intraarterial ... Higashi S, Setoguchi T (December 2000). "Hepatic arterial injection chemotherapy for hepatocellular carcinoma with epirubicin ... It may be given by mouth or by injection, injection being markedly more effective. The origin of this use is attributed to ...
D. Thomas, U. Jaeger, I. Sagoschen, C. Lamberti and K. Wilhelm (2009), Intra-Arterial Calcium Gluconate Treatment After ... Zinc gluconate injections are used to neuter male dogs.[8] Ferrous gluconate injections have been proposed in the past to treat ... Calcium gluconate, in the form of a gel, is used to treat burns from hydrofluoric acid;[5][6] calcium gluconate injections may ... Julie K. Levy, P. Cynda Crawford, Leslie D. Appel, Emma L. Clifford (2008), Comparison of intratesticular injection of zinc ...
Intra-arterial chemotherapy - Chemotherapeutic drugs are administered locally by a thin catheter threaded through the groin, ... Nanoparticulate chemotherapy - To reduce the adverse effects of systemic therapy, subconjuctival (local) injection of ... "Superselective catheterization of the ophthalmic artery for intraarterial chemotherapy for retinoblastoma". Retina ( ...
... recently formed emboli may be treated with catheter-directed thrombolysis using intra-arterial infusion of a thrombolytic agent ... The treatment options include injection of an anticoagulant, thrombolysis, embolectomy, surgical revascularisation, or partial ... Acute arterial occlusion may develop as a result of arterial dissection in the carotid artery or aorta or as a result of ... Paralysis is a very late sign of acute arterial ischemia and signals the death of nerves supplying the extremity. Foot drop may ...
15-35 seconds after injection) when the concentration of contrast material in the arterial system is high (figures 3). Images ... These include: evaluation of renal calculi; assessment for gross intra-abdominal hemorrhage; and post-endostent volume ... Contrast enhanced CT examinations can be acquired at a variety of specific time points after intravenous contrast injection ( ... Images are acquired after a rapid bolus of intravenous contrast material (3-7 cc/s) during the arterial phase ( ...
The protocol with the best-reported survival in children and adults is an intra-arterial protocol where tumor response is ... Generic Strontium Chloride Sr-89 Injection UPS, manufactured by Bio-Nucleonics Inc., it is the generic version of Metastron. ... did not score as highly on the Musculoskeletal Tumour Society Score and Knee Society Score as patients who had undergone intra- ...
The most common medications that cause priapism are intra-cavernous injections for the treatment of erectile dysfunction ( ... which can generate an arterial-lacunar fistula. The mechanisms are poorly understood but involve complex neurological and ... between an artery and the corpus cavernosum or disruption of the parasympathetic nervous system resulting in increased arterial ...
Intra-arterial infusions of mannitol can transiently open the blood-brain barrier by disrupting tight junctions. It may also be ... Medically, it is given by injection. Effects typically begin within 15 minutes and last up to 8 hours. Common side effects from ... USP 32 (2008). "Mannitol Injection" (PDF). Archived from the original (PDF) on 6 July 2010. Retrieved 31 January 2010. Media ... mannitol injection, solution". DailyMed. 15 November 2018. Retrieved 28 October 2020. "Bronchitol EPAR". European Medicines ...
1997 - Intra-arterial delivery of tumor-killing viruses and gene therapy vectors to the liver. 1997 - HIFU first used to treat ... Chemical Ablation: one of the earliest ablative techniques involving the injection of substances such as ethanol or acetic acid ... Cancer Treatment Center of America, Intra-Arterial chemotherapy May, Benjamin J.; Madoff, David C. (June 2012). "Portal vein ... YndyQkSZl5I Intra-arterial chemotherapy: high dose chemotherapy is administered directly into the tumor-feeding arteries. ...
By design, the catheter is smaller than the lumen of the artery it is placed in; internal (intra-arterial) blood pressures are ... Specifically, through the injection of a liquid radiocontrast agent and illumination with X-rays, angiocardiography allows the ... Without the X-ray dye injection, the blood and surrounding heart tissues appear, on X-ray, as only a mildly-shape-changing, ... The physician controls both the contrast injection, fluoroscopy and cine application timing so as to minimize the total amount ...
Intra-articular injection. *Transscleral. Central nervous system. *Intracerebral. *Intrathecal. *Epidural. Circulatory,. ... alveolar-arterial gradient. *hemoglobin. *oxygen-haemoglobin dissociation curve (Oxygen saturation. *2,3-BPG ...
Intra-cranial stenting yang diterapkan pada gejala penyumbatan intracranial arterial stenosis, boleh dikatakan sukses ... "A New Embolus Injection Method to Evaluate Intracerebral Hemorrhage in New Zealand White Rabbits". Cedars-Sinai Medical Center ... Sindrom platipnea-ortodeoksia merupakan kondisi yang jarang terjadi dengan simtoma berupa dispnea dan desaturasi arterial. PFO ... Hal ini dapat terjadi karena iskemia (berkurangnya aliran darah) dikarenakan oleh penyumbatan (thrombosis, arterial embolism), ...
... and traversed by the intra-articular biceps tendon. On imaging, it is defined by the coracoid process at its base, the ... "Arterial Supply to the Rotator Cuff Muscles" (PDF). International Journal of Morphology (1): 136-140. 2014.. CS1 maint: others ... "Corticosteroid Injections Give Small and Transient Pain Relief in Rotator Cuff Tendinosis: A Meta-analysis". Clinical ...
Single dose intra-articular morphine for pain control after knee arthroscopy PMID 27140500 ... Done Botulinum toxin injections for the treatment of spasmodic dysphonia PMID 15266530 ... Wound drainage for lower limb arterial surgery PMID 27841438 ...
Most often they are used intravenously, but for various purposes they can also be used intra-arterially, intrathecally (as in ... The most significant study, proving that injections of ionic (high osmolar) agents are at least as safe as the newer, very ... Angiography (arterial investigations). *Venography (venous investigations). *VCUG (voiding cystourethrography). *HSG ( ... Contrast CT of a patient with brain metastases from breast cancer, before (left) and after (right) injection of iodinated ...
A rise in the arterial partial pressure of CO2 and, to a lesser extent, a fall in the arterial partial pressure of O2, will ... 16 The anatomy of bird's respiratory system, showing the relationships of the trachea, primary and intra-pulmonary bronchi, the ... and a series of steroid injections is frequently administered to the mother during this delay in an effort to promote lung ... where low arterial partial pressures of O2 cause arteriolar vasodilation.) At altitude this causes the pulmonary arterial ...
Intraligamentary infiltration, also known as periodontal ligament injection or intraligamentary injection (ILIs), is known as " ... Ryan, T (2019). "Tramadol as an adjunct to intra‐articular local anaesthetic infiltration in knee arthroscopy: a systematic ... Injection system. J Am Dent Assoc. 1981. *^ Galili D, Kaufman E, Garfunkel AD, et al. Intraligamental anesthesia - a ... Injection of LAs is often painful. A number of methods can be used to decrease this pain, including buffering of the solution ...
Arterial switch operation. Mustard procedure. Senning procedure. for univentricular defect Norwood procedure. Kawashima ... Gurdezi S, White T, Ramesh P (2013). "Alcohol injection for Morton's neuroma: a five-year follow-up". Foot Ankle Int. 34 (8): ... In some conditions, especially forms of intra-nodal re-entry (the most common type of SVT), also called atrioventricular nodal ... RFA is also used in the treatment of Morton's neuroma[35] where the outcome appears to be more reliable than alcohol injections ...
Arterial and venous, with arterial being more common.[8]. *The heart, including coronary artery aneurysms, ventricular ... Li JW, Wang SM, Chen XD (August 2004). "Management of femoral artery pseudoaneurysm due to addictive drug injection". Chinese ... "Application of Patient-Specific Computational Fluid Dynamics in Coronary and Intra-Cardiac Flow Simulations: Challenges and ... Infection. A mycotic aneurysm is an aneurysm that results from an infectious process that involves the arterial wall.[24] A ...
These relative changes are referred to a baseline level, which is typically defined by the intra-thoracic impedance ... has been used to image changes in brain activity after injection of an anaesthetic. One of the benefits of the technique is ... VO2 or arterial blood pressure in sports medicine or home care.[45] ... Further difficulties in absolute EIT arise from inter- and intra-individual differences of electrode conductivity with ...
... increased intra-abdominal pressure (prolonged straining, ascites, an intra-abdominal mass, or pregnancy), genetics, an absence ... Sclerotherapy involves the injection of a sclerosing agent, such as phenol, into the hemorrhoid. This causes the vein walls to ... hemorrhoidal dearterialization is a minimally invasive treatment using an ultrasound doppler to accurately locate the arterial ... The birth of the baby also leads to increased intra-abdominal pressures.[16] Pregnant women rarely need surgical treatment, as ...
Epidural steroid injection[edit]. Main article: Epidural steroid injection. Epidural steroid injection may be used to treat ... Epidural techniques frequently involve injection of drugs through a catheter placed into the epidural space. The injection can ... "Epidural Steroid Injections". Pain Management Specialists.. *^ Norman D (2003). "Epidural analgesia using loss of resistance ... An epidural injection or infusion for pain relief (e.g. in childbirth) is less likely to cause loss of muscle power, but has to ...
Mean arterial blood pressure is measured and kept at 85 to 90 mmHg for seven days after injury. The treatment for shock from ... Another potential cause of SCI is iatrogenic injury, caused by an improperly done medical procedure such as an injection into ... Patients are taught to increase their intra-abdominal pressure by leaning forward to induce cough and clear mild secretions. ...
... of the arteries resulting in abnormally high blood pressure readings with a blood pressure cuff while intra arterial ... injection of substances that caused a fever, indirectly reducing blood pressure). The first chemical for hypertension, sodium ... July 2013). "2013 ESH/ESC guidelines for the management of arterial hypertension: the Task Force for the Management of Arterial ... "2007 ESH-ESC Practice Guidelines for the Management of Arterial Hypertension: ESH-ESC Task Force on the Management of Arterial ...
Diagnosis of septic shock is made when systolic blood pressure is less than 90 mm Hg, a mean arterial pressure (MAP) is less ... YashRoy, R.C. (June 1994). "Liver damage by intra-ileal treatment with Salmonella 3,10:r:- extract as studied by light and ... In 2017, the FDA approved angiotensin II injection for intravenous infusion to increase blood pressure in adults with septic or ... In the initial treatment of low blood pressure in septic shock, the goal of vasopressor treatment is a mean arterial pressure ( ...
Ablative Chemoembolization: Combined injection of chemotherapy and embolic agents into the arterial blood supply of a tumor, ... spontaneous intra-abdominal on intra-thoracic bleeding, bleeding related to trauma and post-surgical bleeding. In some ... In some cases, pseudoaneurysms of the femoral and radial arterials can be a complication of arterial access for endovascular ... Tissue loss refers to arterial insufficiency ulcers, which can progress to frank gangrene. Arterial ulcers are classically ...
Intra-articular analgesia of the DIP joint alleviates lameness associated with the navicular bursa in horses. Vet Surg 1997; 26 ... It is also used to guide injections of treatments (steroids, stems cells, platelet rich plasma) directly into a lesion. Nuclear ... although muscle damage and arterial blood flow have also been evaluated with ultrasound in cases of lameness. Ultrasound is ... Fibrotic myopathy is caused by damage to the hamstring muscles, usually from trauma or intramuscular injection. It results in ...
Qiao J, Feng HL (2010). "Extra- and intra-ovarian factors in polycystic ovary syndrome: impact on oocyte maturation and embryo ... injections followed by in vitro fertilisation (IVF). Though surgery is not commonly performed, the polycystic ovaries can be ... with a meta-analysis estimating a 2-fold risk of arterial disease for women with PCOS relative to women without PCOS, ...
... s can also be classified by their location: Arterial and venous, with arterial being more common. The heart, including ... Li JW, Wang SM, Chen XD (August 2004). "Management of femoral artery pseudoaneurysm due to addictive drug injection". Chinese ... "Application of Patient-Specific Computational Fluid Dynamics in Coronary and Intra-Cardiac Flow Simulations: Challenges and ... A mycotic aneurysm is an aneurysm that results from an infectious process that involves the arterial wall. A person with a ...
Intra-arterial Thiopentone Injection in a Patient with Anomalous Forearm Vessels Br Med J 1956; 2 :754 ... Intra-arterial Thiopentone Injection in a Patient with Anomalous Forearm Vessels. Br Med J 1956; 2 doi: ... Intra-arterial.... *Intra-arterial Thiopentone Injection in a Patient with Anomalous Forearm Vessels ...
Selective Intra-arterial Injection of PRRT in Neuroendocrine Tumor Patients With Liver Metastases. The safety and scientific ... Selective Intra-arterial Injection of Peptide Receptor Radionuclide Therapy (PRRT) in Neuroendocrine Tumor Patients With Liver ... Intra-arterial infusion to the liver of [90]Y-DOTATOC. The administered dose is determined by cohort and is dependent upon the ... Intra-arterial infusion to the liver of [90]Y-DOTATOC. The administered dose is determined by cohort and is dependent upon the ...
... and treatment regimens for accidental intra-arterial inje ... "inadvertent intra-arterial injection" as well as "intra- ... Risk factors for iatrogenic intra-arterial injection. In the clinical setting, iatrogenic intra-arterial injection of ... intra-arterial thrombosis was observed.44. Although the intra-arterial injection of propofol causes severe pain on injection, ... can help identify arterial tubing injection ports.14 Should an intra-arterial injection occur, knowledge of the agents that are ...
The Effect of Intra-arterial Injections of Hydergine and Dihydroergocornine on the Peripheral Circulation in Man. ROBERT H. ... The Effect of Intra-arterial Injections of Hydergine and Dihydroergocornine on the Peripheral Circulation in Man ... The Effect of Intra-arterial Injections of Hydergine and Dihydroergocornine on the Peripheral Circulation in Man ... The Effect of Intra-arterial Injections of Hydergine and Dihydroergocornine on the Peripheral Circulation in Man ...
Reserpine in Raynauds Disease and Phenomenon: Short-Term Response to Intra-arterial Injection Annals of Internal Medicine; 72 ... Digital Vascular Responses in Normotensive and Hypertensive Subjects to Intravenous and Intra-arterial Injections of Synthetic ... Digital Vascular Responses in Normotensive and Hypertensive Subjects to Intravenous and Intra-arterial Injections of Synthetic ... the digital vascular responses to arterial and venous injections of this substance were studied in 20 normotensive and ...
Impact of Intra-Arterial Injection Parameters on Arterial, Capillary, and Venous Time-Concentration Curves in a Canine Model. A ... Impact of Intra-Arterial Injection Parameters on Arterial, Capillary, and Venous Time-Concentration Curves in a Canine Model ... Impact of Intra-Arterial Injection Parameters on Arterial, Capillary, and Venous Time-Concentration Curves in a Canine Model ... Impact of Intra-Arterial Injection Parameters on Arterial, Capillary, and Venous Time-Concentration Curves in a Canine Model ...
Khan, Z.H. and Faghihnassiri, S. (2016) An accidental intra-arterial injection of phenytoin in a 43-year-old woman. Saudi ... We report an accidental intra-arterial injection of phenytoin in a 43-year-old woman undergoing ventriculoperitoneal shunt for ... We report an accidental intra-arterial injection of phenytoin in a 43-year-old woman undergoing ventriculoperitoneal shunt for ... ReTweet if useful... Accidental intra-arterial injection of phenytoin @ivteam #ivteam ...
RESULTS--Intra-arterial injection of Temazepam gel may cause severe vascular injury and lead to amputation of fingers or limbs ... Limb ischaemia after intra-arterial injection of Temazepam gel: histology of nine cases. ... Limb ischaemia after intra-arterial injection of Temazepam gel: histology of nine cases. ... AIMS--To record the histopathological findings associated with intra-arterial injection of Temazepam gel by nine drug misusers ...
X-ray angiography perfusion imaging with an intra-arterial injection: comparative study with 15O-gas/water positron emission ... XAP was performed with intra-arterial infusion of contrast media, and a time-density curve was constructed for each cerebral ...
Troisi N, Farina A, Chisci E, Ercolini L, Frosini P, Pigozzi C, et al. Intra-arterial injection of iloprost reduces the risk of ... Intra-arterial injection of iloprost reduces the risk of early recoil after balloon angioplasty of below-the-knee vessels in ... The aim of this study was to evaluate the impact of intra-arterial administration of iloprost (Endoprost®, Italfarmaco S.p.A., ... CONCLUSIONS: In our experience intra-arterial administration of iloprost reduces the risk of early elastic recoil after balloon ...
Hemodynamic changes associated with the intra-arterial injection of contrast media. New toxicity tests and a new experimental ... Hemodynamic changes associated with the intra-arterial injection of contrast media. New toxicity tests and a new experimental ... article{Hilal1966HemodynamicCA, title={Hemodynamic changes associated with the intra-arterial injection of contrast media. New ... Effect of Saline Injection Mixing on Accuracy of Conductance Lumen Sizing of Peripheral Vessels. *Hyo Won Choi, Benjamin Jansen ...
... *JOHN A. KNOWLES. *Archives of Pediatrics and Adolescent Medicine, May 1966 ...
INTRA-ARTERIAL INJECTION OF PENICILLIN FOR INFECTIONS OF THE EXTREMITIES: PRELIMINARY REPORT. ... GLASSER ST, HERRLIN J, POLLOCK B. INTRA-ARTERIAL INJECTION OF PENICILLIN FOR INFECTIONS OF THE EXTREMITIES: PRELIMINARY REPORT ... HISTORY The history of intra-arterial therapy dates back to 1914. In this year Goyanes1 in Spain, Fiolle2 in France and Heddaus ... We present what we believe to be, the first series in which penicillin was administered by the intra-arterial route. The ...
Risk of Intra-Arterial Injection There have been limited reports of intra-arterial injection of midazolam hydrochloride. ... Midazolam injection should only be administered IM or IV (see WARNINGS). Care should be taken to avoid intra-arterial injection ... Precautions against unintended intra-arterial injection should be taken. Extravasation should also be avoided. ... Integumentary: Hive-like elevation at injection site, swelling or feeling of burning, warmth or coldness at injection site ...
... intraarterial chemotherapy with or without osmotic opening of the BBB is feasible across multiple centers with a low incidence ... Injections, Intra-Arterial / adverse effects * Injections, Intra-Arterial / instrumentation * Karnofsky Performance Status ... Background: The aim of this study was to determine the safety and efficacy of intraarterial chemotherapy with osmotic opening ... Standardized anesthesia and intraarterial catheterization guidelines were followed by a multidisciplinary team at each center. ...
Systemic toxicity was low for IAO and periocular injection, but children who received sequentially intravenous chemotherapy (n ... Intra-arterial chemotherapy is more effective than sequential periocular and intravenous chemotherapy as salvage treatment for ... This study compares the efficacy and toxicity of intra-arterial ophthalmic artery chemotherapy (IAO) to our historical cohort ...
The effect of intra-arterial injection of radiopaque contrast media on coronary blood flow.,Author:TALBERT J L,JOYCE E E, ...
Intra-arterial Chemotherapy. Powerful drug delivery. "With intraarterial chemotherapy, you can get a more powerful dose of ... The injection is administered through a 32-gauge needle to minimize the diameter of the scleral opening, which is only about 10 ... Unanswered questions about intraarterial chemo. Nevertheless, intra-arterial chemotherapy for retinoblastoma is not without ... Intra-arterial chemotherapy was developed and has been used in Japan since the late 1980s, and a somewhat different technique ...
Administration of Intra-arterial Injection instead of Intravenous: Doctor, Vimhans Hospital to pay Rs 20 lakh. 4. Editors pick ... "The phenargan injection has been given intra-arterial inadverntely which is also evident from the Doppler report. This has ... "In view of the discussion above we are left with no option to conclude that the child was given injection Intra arterial ... 4 comment(s) on Administration of Intra-arterial Injection instead of Intravenous: Doctor, Vimhans Hospital to pay Rs 20 lakh ...
Fluorouracil arterial infusion and interferon therapy (FAIT) is another intra-arterial injection regimen. One cycle of ... the patient may receive injections as an outpatient for the intra-arterial injection method using the reservoir system, with ... This therapy is an intra-arterial injection regimen in which a small amount of CDDP (10 mg/body/day or 10 mg/m2/day, days 1 to ... 3. Intra-arterial injection using cisplatin alone. Cisplatin (IA-call®) is a powdered cisplatin (cis-diamminedichloroplatinum, ...
Intra-arterial and perivascular injections.. Cardiopulmonary resuscitation.. Postoperative myopathy.. Neuropathy.. Hyperkalemic ...
Intra-arterial (Ophthalmic Artery) Chemotherapy for Retinoblastoma. Resource links provided by NLM:. Genetics Home Reference ... A Study of the Effectiveness of a Local Injection of Chemotherapy for Retinoblastoma (IAC-RB). This study has been completed. ...
Intra-arterial injections - -. Vasovagal fainting (VVF) alone 4 6. Headaches alone - -. Paresthesias alone 2 1. Nausea, ... Infiltración arterial y periarterial con procaina 1%. Enfriamiento con ice packs. Heparinización inmediata por 6 dias o mas. ... Lidocaína TROMBOFLEBITIS SUPERFICIAL ETIOLOGÍA TRATAMIENTO ASA AINES HBPM HEPARINA TÓPICA DRENAJE INYECCIÓN INTRAARTERIAL ...
Injections, Intra-Arterial. Injections, Intravenous. Chemotherapy, Adjuvant. Additional relevant MeSH terms:. Layout table for ... Intra-arterial chemotherapy with or without embolisation is a largely evaluated therapeutic approach whose results are ... Three groups will be compared: a group of untreated patients (n=109), a group of patients treated by intra-arterial ... Postoperative treatment means either intra-arterial chemotherapy or systemic chemotherapy. The main criterion of the study is ...
... intra-arterial injection; use in premature infants. Canadian labeling: Additional contraindications (not in the US labeling): ... Avoid intra-arterial administration. Avoid extravasation.. Continuous IV infusion (off-label administration mode; Barr 2013) ... Local: Pain at injection site (IM: 1% to 17%; IV: ≤2%), erythema at injection site (≤2%) ... IV injection: Dilute prior to use (according to the manufacturer). Do not exceed 2 mg/minute or 0.05 mg/kg over 2 to 5 minutes ...
Injections, Intra-Arterial. *Injections, Intravenous. *Iodobenzoates. *Iodobenzoates: administration & dosage. *Iohexol. *Male ...
... insertion/removal of intra-arterial lines; and the simple administration of injections. The principles described above are also ... Other activities involve exposure to blood and body fluids but are much lower risk for disease transmission: such as arterial ...
To determine the value of selective intra-arterial calcium stimulation with hepatic venous sampling using serum insulin and C- ... Injections, Intra-Arterial. Insulinoma / diagnosis*. Male. Pancreatic Neoplasms / diagnosis*. Preoperative Care. Tomography, X- ... Other recent studies have shown that selective intra-arterial stimulation with hepatic venous sampling using intra-arterial ... conditions considered relative contraindications to intra-arterial calcium injection. All tests were carried out under local ...
... arterial injections of chemotherapeutic drugs in advanced c The use and efficacy of intra--arterial injections of ... Injections, Intra-Arterial / Mechlorethamine Language: English Journal: Indian J Cancer Year: 1967 Type: Article ... Injections, Intra-Arterial / Mechlorethamine Language: English Journal: Indian J Cancer Year: 1967 Type: Article ... Injections, Intra-Arterial , Mechlorethamine/administration & dosage , Methotrexate/administration & dosage , Mouth Neoplasms/ ...
  • 1 The replacement of thiopental with propofol in contemporary anesthetic practice has clearly reduced thiopental-related complications but iatrogenic intra-arterial injection-related injuries still occur. (
  • METHODS: Between January 2015 and December 2015 32 patients with CLI underwent balloon angioplasty of at least one BTK vessel followed by intra-arterial administration of iloprost. (
  • Intra-arterial infusion to the liver of [90]Y-DOTATOC. (
  • XAP was performed with intra-arterial infusion of contrast media, and a time-density curve was constructed for each cerebral hemisphere. (
  • Therefore, patients with advanced HCC are usually treated with hepatic arterial infusion chemotherapy (HAIC), which is increasingly used as an approach to advanced HCC in Japan. (
  • In hepatic arterial infusion chemotherapy (HAIC), an increase in the anti-tumor effect against malignant tumors may be expected in the liver by injecting a highly concentrated chemotherapeutic agent directly into the liver, via the hepatic artery, in order to topically increase the concentration of the chemotherapeutic agent at the tumor site. (
  • and the reservoir intra-arterial injection, in which a reservoir system is embedded under the skin for continuous infusion or repetitive administration. (
  • 222-94) This invention relates to apparatus for the pressure infusion of liquids and pertains more specifically to apparatus for intravenous injection of solutions under controlled pressure. (
  • When thiopental is used as the sole anesthetic agent, the desired level of anesthesia can be maintained by injection of small repeated doses as needed or by using a continuous intravenous infusion with a 0.2% or 0.4% concentration (see section 6.6). (
  • Subcutaneous injection and intra-arterial infusion are not indicated. (
  • This study aims to explore the efficacy and safety of intra- arterial infusion of gemcitabine and oxaliplatin in locally advanced pancreatic cancer. (
  • One of the most demanding aspects of outpatient coding is the selection of injection and infusion (I&I) codes. (
  • Inadvertent intra-arterial injection can also result in endarteritis and thrombosis, with ultimately similar consequences. (
  • Because the octapeptide angiotensin II may also participate in local regulation of blood flow, the digital vascular responses to arterial and venous injections of this substance were studied in 20 normotensive and hypertensive subjects resting in bed in an environmentally controlled room. (
  • Selective intra-arterial calcium stimulation with hepatic venous sampling for preoperative localization of insulinomas. (
  • OBJECTIVE: To determine the value of selective intra-arterial calcium stimulation with hepatic venous sampling using serum insulin and C-peptide gradients for the preoperative localization of insulinomas. (
  • MATERIALS AND METHODS: Seven consecutive patients (three men and four women aged 15-77 (mean, 42.7) years) with hypoglycemia underwent selective intra-arterial calcium stimulation in conjunction with hepatic venous sampling. (
  • CONCLUSION: Selective intra-arterial calcium stimulation with hepatic venous sampling is a highly accurate and safe method for the preoperative localization of insulinomas. (
  • The observation of venous pain is not associated with a more than usual incidence of thrombosis or thrombophlebitis at the injection site. (
  • A smaller number of cases have been reported regarding the use of drugs injected directly into the arm, forearm, or wrist, leading to arterial and or venous injury and constriction, subsequent thrombosis, and compartment syndrome (2, 3, 4). (
  • She resorted to injecting herself in the 1st web space of the hand and thenar eminence, but claims that she did not notice the regular return of blood in her needle she was accustomed to with injections elsewhere in her body with direct venous access. (
  • Venous and arterial ultrasound studies of the effected extremity were negative for thrombosis or vascular compromise. (
  • Nevertheless, intra-arterial chemotherapy for retinoblastoma is not without controversy. (
  • Thus, intraarterial delivery of agents like 3-BrPA directly to the site of the primary tumor, followed by systemic delivery only when necessary, may represent a powerful new strategy for arresting the growth of liver and other cancers while minimizing toxic side effects. (
  • Tumor-killing medicines are given by mouth, through an injection (a shot), or intravenously (into a vein). (
  • To flush the arterial line with heparin, mistakenly phenytoin was injected which caused cutaneous gangrene along the radial side of the forearm and an absence of pulsation in the radial artery. (
  • A case of limb gangrene secondary to accidental intra-arterial [I.A.] diazepam injection in an infant is described. (
  • Arterial damage - Arterial pseudoaneurysms may form at injection sites, which can rupture, potentially resulting in hemorrhage, distal ischemia, and gangrene. (
  • The aim of this study was to determine the safety and efficacy of intraarterial chemotherapy with osmotic opening of the blood-brain barrier (BBB) for the treatment of malignant brain tumors when administered across multiple centers. (
  • This study compares the efficacy and toxicity of intra-arterial ophthalmic artery chemotherapy (IAO) to our historical cohort of sequential periocular and systemic chemotherapy in such patients. (
  • The use and efficacy of intra--arterial injections of chemotherapeutic drugs in advanced cases of oral carcinomas. (
  • I n 1948, during the course of studies on seizure mechanisms, one of us (J.W.) carried out intracarotid injection of Sodium Amytal and Metra-zol to investigate the mechanism of the spread of epileptic discharge between the cerebral hemispheres in man. (
  • 9-11 The intracarotid injection of Sodium Amytal was found to induce a temporary loss of function in the ipsilateral cerebral hemisphere, including aphasia when the dominant hemisphere was injected. (
  • Background- Intra-arterial cerebral angiography is associated with a low risk for neurological complications, but clinically silent ischemic events after angiography have been seen in a substantial number of patients. (
  • Methods and Results- In a prospective study, diffusion-weighted magnetic resonance imaging (DW-MRI) before and after intra-arterial cerebral angiography and transcranial Doppler sonography during angiography were used to evaluate the frequency of cerebral embolism. (
  • Conclusions- Air filters and heparin both reduce the incidence of silent ischemic events detected by DW-MRI after intra-arterial cerebral angiography and can potentially lower clinically overt ischemic complications. (
  • Intra-arterial digital subtraction angiography (IA-DSA) has remained the "gold standard" in the assessment of cerebral vessels. (
  • However, cerebral arterial pulsation could not be directly assessed. (
  • These findings demonstrate that cerebral arterial pulsatility is a key driver of paravascular CSF influx into and through the brain parenchyma, and suggest that changes in arterial pulsatility may contribute to accumulation and deposition of toxic solutes, including amyloid β, in the aging brain. (
  • Based upon these findings, we proposed that cerebral arteries provide an anatomical pathway to facilitate efficient CSF-ISF exchange in the brain, and that arterial pulsation provides the driving force for this process. (
  • Mr. King had 256 injections into his arms, legs, buttocks and abdomen, including 90 Heparin injections into his abdomen. (
  • Agonists were injected as an intraarterial bolus, whereas SR141716A was included in the perfusion buffer. (
  • Phenylephrine (PE, 15 μM) used to precontract the preparation and CBD were included in the perfusion buffer, as indicated by the horizontal lines, and the bolus injection of 4 mg of Abn-cbd is indicated by the arrows. (
  • In patients with acute vision loss from nonarteritic central retinal artery occlusion, acute strategies to restore retinal perfusion include noninvasive "standard" therapies and thrombolysis (intravenous or intra-arterial). (
  • Atypical chest pain: coronary, aortic and pulmonary vasculature enhancement at biphasic single-injection 64-section CT angiography. (
  • In such disorders as vasculitis or intracranial aneurysms, the sensitivity and specificity of such noninvasive techniques as CT angiography and MR angiography do not suffice to replace intra-arterial angiography. (
  • Accidental intra-arterial drug injection is an uncommon complication of anesthetic and critical care practice, and is associated with serious morbidity, including chronic pain and tissue necrosis, often necessitating amputation. (
  • Two cases involved accidental intra-arterial injection and resulted in tissue necrosis leading to the amputation of a forearm and of fingertips, respectively. (
  • Midazolam hydrochloride is a water-soluble benzodiazepine available as a sterile, nonpyrogenic parenteral dosage form for intravenous or intramuscular injection. (
  • Momentary apnea following each injection is typical, and progressive decrease in the amplitude of respiration appears with increasing dosage. (
  • Injection delivers a dosage in one "shot" rather than over a period of time. (
  • RESULTS--Intra-arterial injection of Temazepam gel may cause severe vascular injury and lead to amputation of fingers or limbs. (
  • Chemotherapy is one of the most significant treatment options for patients with advanced HCC not indicated for hepatic resection, percutaneous ablation and transcatheter arterial chemoembolization. (
  • Intra-arterial and intravitreal chemotherapy can be more potent than intravenous therapy and can cause dramatic regression of tumors in advanced retinoblastoma. (
  • Intra-arterial chemotherapy has really improved care for retinoblastoma children, and more children than ever are having their eyes saved with this treatment," Dr. Shields said. (
  • Different agents and methods of administering intra-arterial chemotherapy are now being used around the world, but prospective trials would standardize the protocol," said Patricia Chévez-Barrios, MD, at the Retinoblastoma Center of Houston. (
  • The point of a prospective trial would be to find out which retinoblastoma patients benefit most from intra-arterial chemotherapy and which patients should be selected for this treatment. (
  • Although other drugs have been used, the powerful chemotherapy agent melphalan is often the medication of choice for intra-arterial chemotherapy, according to Dr. Shields. (
  • Dr. Gombos noted that melphalan, the drug most often used in intraarterial chemotherapy, is far more toxic than the agents used for intravenous chemotherapy. (
  • Thereafter, Dr Sinha gave injection 'phenargan' IV, 25 mg in the brachial artery. (
  • He denied that he had administered the injection in the brachial artery or anywhere near it. (
  • This technique involves the injection of local anesthetic agents in close proximity to the brachial plexus, temporarily blocking the sensation and ability to move the upper extremity. (
  • Most of these injuries are caused by accidental injection into an established arterial cannula or the inadvertent and unrecognized cannulation of an artery instead of a vein. (
  • Accidental intra-arterial injection of medications has also been increasingly reported in those who use illicit drugs, as these intravenous injection attempts can be misdirected into an artery. (
  • Some case reports of ophthalmic artery occlusion after intra-arterial chemotherapy have also raised concerns. (
  • Aggrieved by the treatment received at Vimhans, the patient filed the complaint with the consumer forum contending that the doctor ought to have checked whether the injection was being administered in the vein or in the artery. (
  • In view of the obvious importance of accurate knowledge of the lateralization of speech dominance when operating near the Sylvian regions in ambidextrous and left-handed individuals, further studies regarding the technique of intracarotid injection of Sodium Amytal seemed indicated, particularly with regard to the margin of safety in relation to dose and to the effect of accidental injection into the vertebral artery. (
  • One to 6 injections of varying doses of Sodium Amytal (10 per cent solution with 1 exception) were made in each monkey into the exposed common carotid or vertebral artery, using a tuberculin or 2 cc. syringe. (
  • In the remainder of the experiments, the injection was made through a 27 gauge hypodermic needle inserted into the artery. (
  • The artery is more sensitive to pain because it has nerves close to it, so arterial sticks are more painful. (
  • Twenty sidewall aneurysms were created in 10 rabbits by suturing a decellularized arterial vessel pouch on the carotid artery of a donor rabbit. (
  • During follow-up at one month after creation, the parent artery/aneurysm complex was dissected and FVA was performed using an intravenous fluorescein (10%, 1 mL) injection via an ear vein catheterization in rabbits and a femoral vein catherization in rats. (
  • The lateral aspect of the index finger and the thumb normally receive their arterial supply from the radial artery through the radialis indicis and the princeps pollicis arteries, respectively. (
  • Local intra-arterial fibrinolysis for acute occlusion of the central retinal artery: a meta-analysis of the published data. (
  • Central retinal artery occlusion: local intra-arterial fibrinolysis versus conservative treatment, a multicenter randomized trial. (
  • Hemodynamic changes associated with the intra-arterial injection of contrast media. (
  • The effect of intra-arterial injection of radiopaque contrast media on coronary blood flow. (
  • In the report, I focused on five major areas: intramuscular injections, intravenous and intra-arterial sticks, nasogastric tube insertions, suctioning, and comments Mr. King made. (
  • Although today many more medications are given intravenously, in Mr. King's time, intramuscular injections were common. (
  • Intramuscular injections are given when the substance needs to be absorbed quickly. (
  • Although initial reports were following intramuscular injections, the reaction has since also been reported following subcutaneous, intravenous, and intraarticular injections. (
  • Effect of volume and rate of contrast medium injection on intravenous digital subtraction angiographic contrast medium curves. (
  • This may apply to any intra-arterial angiographic procedure. (
  • Even with the higher local concentrations possible by the intra-arterial route, the hydrogenated alkaloids of ergot still did not exhibit any adrenolytic action on the peripheral blood vessels in man. (
  • Pharmacokinetic studies following an I.V. injection have shown that methylergonovine is rapidly distributed from plasma to peripheral tissues within 2-3 minutes or less. (
  • Although it is invasive, an intracarotid FNa injection results in faster contrast appearance and higher-intensity fluorescence and requires a lower dose per injection (reported range, 1-50 mg) compared with peripheral intravenous FNa injection (reported range, 75-2,000 mg or 1-1.5 mg/kg body weight). (
  • As regards the injection, it was administered intravenously as per medical records, the counsel for the hospital contended. (
  • Never give the 50mg/mL promethazine intravenously, because this strength is intended for deep intramuscular injection only. (
  • Limb ischaemia after intra-arterial injection of Temazepam gel: histology of nine cases. (
  • The aim of this study was to evaluate the impact of intra-arterial administration of iloprost (Endoprost®, Italfarmaco S.p.A., Milan, Italy) on early elastic recoil after balloon angioplasty of below-the-knee (BTK) vessels in patients with critical limb ischemia (CLI). (
  • Postoperative treatment means either intra-arterial chemotherapy or systemic chemotherapy. (
  • We propose to test by a prospective randomized multicentric phase III study, the effectiveness of an adjuvant treatment by systemic chemotherapy or intra-arterial LIPIODOLISED chemotherapy (CIAL), after surgery or complete local destruction of HCC. (
  • Cilioretinal arteries and retinal arterial occlusion. (
  • We present what we believe to be, the first series in which penicillin was administered by the intra-arterial route. (
  • Since these injuries are frequently complicated by infection, a preliminary report on the utilization of penicillin by the arterial route would seem to be timely. (
  • Biousse V. Acute retinal arterial ischemia: an emergency often ignored. (
  • Despite awareness of the issue and the establishment of safety recommendations by national agencies, accidental iatrogenic intra-arterial injection of medications continues to occur. (
  • Owing to the small and sporadic number of cases, no definitive clinical trial evidence exists, but the treatment modalities found to be useful in the illicit intra-arterial injection group may benefit treatment of similar iatrogenic injuries. (
  • Livedoid dermatitis is a iatrogenic cutaneous reaction that occurs immediately after a drug injection. (
  • Several non-surgical treatment options, including transcatheter arterial chemoemobolization (TACE) and radiofrequency ablation (RFA) have been developed and are widely used in patients with unresectable HCC. (
  • Treatment may be given by intravenous or intramuscular injection and repeated for up to 5 days. (
  • If symptomatic spasm were detected, immediate intraarterial FH injection or percutaneous transluminal angioplasty was performed. (
  • When using a regimen in which the time required for an intra-arterial injection is short and where administration is required only at a frequency of approximately once a month (for example, epirubicin hydrochloride, cisplatin and other similar agents), the one-shot intra-arterial injection is possible. (
  • Systemic toxicity was low for IAO and periocular injection, but children who received sequentially intravenous chemotherapy (n = 12 cycles) had five episodes of grade 4 neutropenia, three of which resulted in hospitalizations. (
  • However, injection of crushed methylphenidate pills lead to serious local toxicity. (
  • CONCLUSIONS: In our experience intra-arterial administration of iloprost reduces the risk of early elastic recoil after balloon angioplasty of BTK vessels in patients with CLI. (
  • Doctors at AIIMS informed that the damage had been caused to most of the fingers due to wrong administration of injection and the same could not be reversed. (
  • and the simple administration of injections. (
  • If the test dose results in local or regional pain, extravasal or intraarterial administration should be suspected (see section 4.4. (
  • Etomidate Injection, USP is intended for administration only by the intravenous route (see CLINICAL PHARMACOLOGY ). (
  • The boxed warning will remind practitioners that due to the risks of intravenous injection, the preferred route of administration is deep intramuscular injection and that subcutaneous injection is contraindicated (FDA, 2009). (
  • It is shown, in an animal model of chronic ethanol intake and relapse-drinking, that both the intravenous and intra-cerebroventricular administration of a single dose of MSC-spheroids inhibited chronic ethanol intake and relapse-like drinking by 80-90%, displaying significant effects over 3-5 weeks. (
  • Clearly, the intra-cerebroventricular administration is not a preferred route for the treatment of a chronic disease such alcoholism. (
  • It seems likely that the administration of the antibody via the intra-arterial route contributed to the development of this condition. (
  • We report an accidental intra-arterial injection of phenytoin in a 43-year-old woman undergoing ventriculoperitoneal shunt for hydrocephalus" Khan and Faghihnassiri (2016). (
  • Khan, Z.H. and Faghihnassiri, S. (2016) An accidental intra-arterial injection of phenytoin in a 43-year-old woman. (
  • Adults and adolescents over 12 years of age receive 1 to 2 ampoules of Phenytoin (equivalent to 230 to 460 mg phenytoin) daily at a maximum rate of injection of 0.5 ml/min (equivalent to 23 mg phenytoin per minute). (
  • Comparison of long-term effects between intra-arterially delivered ethanol and Gelfoam for the treatment of severe arterioportal shunt in patients with hepatocellular carcinoma. (
  • Stop any injections or infusions of this medication if your patient suddenly starts complaining of pain or burning. (
  • Infusions are primary to pushes, which are primary to injections. (
  • But since infusions, injections, and hydrations are most common in the ED setting, this article will continue the I&I discussion without a focus on chemotherapy. (
  • The doctor further contended that he had administered the said injection through the cannula which was fixed on the back of the right hand over the anatomical snuff box. (
  • HISTORY The history of intra-arterial therapy dates back to 1914. (
  • in contrast, intra-arterial chemotherapy can produce up to 100 percent cancer control in these advanced cancers when used as a primary therapy. (
  • Pedersen, Peter L. / Novel therapy for liver cancer : Direct intraarterial injection of a potent inhibitor of ATP production . (
  • Group B patients include the intensive care group for treating SAH, and we employed multimodality therapy on Group B by using intraventricular urokinase (UK) injection, lumbar (LD) or cisternal drainages (CD) and timely intraarterial fasudil hydrochloride (FH) injection in the second half of the period with a standardized protocol. (
  • CONCLUSIONS--Inadvertent injection of Temazepam gel into arteries may cause catastrophic ischaemic damage, possibly as a result of toxic effects on endothelial cells. (
  • Prior reports have suggested that paravascular bulk flow of CSF or ISF may be driven by arterial pulsation. (
  • Drug injection is a method of introducing a drug into the bloodstream via a hollow hypodermic needle and a syringe, which is pierced through the skin into the body (usually intravenous, but also intramuscular or subcutaneous). (
  • Observation of local anesthetic surrounding the nerves during ultrasound-guided injection is predictive of a successful block. (
  • The Delhi State Consumer Disputes Redressal Commission has directed Vimhans Hospital and physician attached to the hospital to pay Rs 20 lakh compensation the patient who was negligently administered intra-arterial injection instead of an intravenous one by the doctor. (
  • Moderately slow induction can usually be accomplished in a healthy female or male adult weighing 60-80 kg by injection of 50 to 75 mg of thiopental at intervals of 20 to 40 seconds, depending on the reaction of the patient. (
  • Once anesthesia is established, additional injections of 25 to 50 mg can be given whenever the patient moves. (
  • We hypothesized that intra-arterial gemcitabine/oxaliplatin administered as second-line treatment could strongly improve objective response rate at 4 months after inclusion in patient with. (
  • This narrative review discusses the incidence, risk factors, mechanisms of injury, complications, and treatment regimens for accidental intra-arterial injection of medications. (
  • Etomidate Injection, USP is compatible with commonly administered pre-anesthetic medications, which may be employed as indicated. (
  • There was a high clinical suspicion of an evolving compartment syndrome at this time, and intra-compartmental pressures via a Stryker Needle were ascertained on the 1st dorsal interosseous web space (measuring 56 mmHg) and thenar compartment (measuring 58 mmHg). (
  • To achieve an optimal block, the tip of the needle should be close to the nerves of the plexus during the injection of local anesthetic solution. (
  • He also did not adopt the standard procedure while administering the injection of phenargan. (