The long-term (minutes to hours) administration of a fluid into the vein through venipuncture, either by letting the fluid flow by gravity or by pumping it.
The administration of liquid medication, nutrient, or other fluid through some other route than the alimentary canal, usually over minutes or hours, either by gravity flow or often by infusion pumping.
Fluid propulsion systems driven mechanically, electrically, or osmotically that are used to inject (or infuse) over time agents into a patient or experimental animal; used routinely in hospitals to maintain a patent intravenous line, to administer antineoplastic agents and other drugs in thromboembolism, heart disease, diabetes mellitus (INSULIN INFUSION SYSTEMS is also available), and other disorders.
Regional infusion of drugs via an arterial catheter. Often a pump is used to impel the drug through the catheter. Used in therapy of cancer, upper gastrointestinal hemorrhage, infection, and peripheral vascular disease.
Implanted fluid propulsion systems with self-contained power source for providing long-term controlled-rate delivery of drugs such as chemotherapeutic agents or analgesics. Delivery rate may be externally controlled or osmotically or peristatically controlled with the aid of transcutaneous monitoring.
The administration of liquid medication or nutrients under the skin, usually over minutes or hours.
The administration of medication or fluid directly into localized lesions, by means of gravity flow or INFUSION PUMPS.
PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS.
The relationship between the dose of an administered drug and the response of the organism to the drug.
Time schedule for administration of a drug in order to achieve optimum effectiveness and convenience.
The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)
Injections made into a vein for therapeutic or experimental purposes.
The movement and the forces involved in the movement of the blood through the CARDIOVASCULAR SYSTEM.
Elements of limited time intervals, contributing to particular results or situations.
Portable or implantable devices for infusion of insulin. Includes open-loop systems which may be patient-operated or controlled by a pre-set program and are designed for constant delivery of small quantities of insulin, increased during food ingestion, and closed-loop systems which deliver quantities of insulin automatically based on an electronic glucose sensor.
The delivery of a drug into a fluid-filled cavity of the brain.
A 51-amino acid pancreatic hormone that plays a major role in the regulation of glucose metabolism, directly by suppressing endogenous glucose production (GLYCOGENOLYSIS; GLUCONEOGENESIS) and indirectly by suppressing GLUCAGON secretion and LIPOLYSIS. Native insulin is a globular protein comprised of a zinc-coordinated hexamer. Each insulin monomer containing two chains, A (21 residues) and B (30 residues), linked by two disulfide bonds. Insulin is used as a drug to control insulin-dependent diabetes mellitus (DIABETES MELLITUS, TYPE 1).
Glucose in blood.
A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.
The number of times the HEART VENTRICLES contract per unit of time, usually per minute.
Use of any infusion therapy on an ambulatory, outpatient, or other non-institutionalized basis.
A primary source of energy for living organisms. It is naturally occurring and is found in fruits and other parts of plants in its free state. It is used therapeutically in fluid and nutrient replacement.
Emulsions of fats or lipids used primarily in parenteral feeding.
The flow of BLOOD through or around an organ or region of the body.
Any of the ruminant mammals with curved horns in the genus Ovis, family Bovidae. They possess lachrymal grooves and interdigital glands, which are absent in GOATS.
The administration of medication or fluid through a needle directly into the bone marrow. The technique is especially useful in the management of pediatric emergencies when intravenous access to the systemic circulation is difficult.
An octapeptide that is a potent but labile vasoconstrictor. It is produced from angiotensin I after the removal of two amino acids at the C-terminal by ANGIOTENSIN CONVERTING ENZYME. The amino acid in position 5 varies in different species. To block VASOCONSTRICTION and HYPERTENSION effect of angiotensin II, patients are often treated with ACE INHIBITORS or with ANGIOTENSIN II TYPE 1 RECEPTOR BLOCKERS.
An intravenous anesthetic agent which has the advantage of a very rapid onset after infusion or bolus injection plus a very short recovery period of a couple of minutes. (From Smith and Reynard, Textbook of Pharmacology, 1992, 1st ed, p206). Propofol has been used as ANTICONVULSANTS and ANTIEMETICS.
A ubiquitous sodium salt that is commonly used to season food.
Ultrashort-acting anesthetics that are used for induction. Loss of consciousness is rapid and induction is pleasant, but there is no muscle relaxation and reflexes frequently are not reduced adequately. Repeated administration results in accumulation and prolongs the recovery time. Since these agents have little if any analgesic activity, they are seldom used alone except in brief minor procedures. (From AMA Drug Evaluations Annual, 1994, p174)
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
The active sympathomimetic hormone from the ADRENAL MEDULLA. It stimulates both the alpha- and beta- adrenergic systems, causes systemic VASOCONSTRICTION and gastrointestinal relaxation, stimulates the HEART, and dilates BRONCHI and cerebral vessels. It is used in ASTHMA and CARDIAC FAILURE and to delay absorption of local ANESTHETICS.
Precursor of epinephrine that is secreted by the adrenal medulla and is a widespread central and autonomic neurotransmitter. Norepinephrine is the principal transmitter of most postganglionic sympathetic fibers and of the diffuse projection system in the brain arising from the locus ceruleus. It is also found in plants and is used pharmacologically as a sympathomimetic.
Volume of biological fluid completely cleared of drug metabolites as measured in unit time. Elimination occurs as a result of metabolic processes in the kidney, liver, saliva, sweat, intestine, heart, brain, or other site.
The force that opposes the flow of BLOOD through a vascular bed. It is equal to the difference in BLOOD PRESSURE across the vascular bed divided by the CARDIAC OUTPUT.
A 29-amino acid pancreatic peptide derived from proglucagon which is also the precursor of intestinal GLUCAGON-LIKE PEPTIDES. Glucagon is secreted by PANCREATIC ALPHA CELLS and plays an important role in regulation of BLOOD GLUCOSE concentration, ketone metabolism, and several other biochemical and physiological processes. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p1511)
Body organ that filters blood for the secretion of URINE and that regulates ion concentrations.
A method of studying a drug or procedure in which both the subjects and investigators are kept unaware of who is actually getting which specific treatment.
Any process by which toxicity, metabolism, absorption, elimination, preferred route of administration, safe dosage range, etc., for a drug or group of drugs is determined through clinical assessment in humans or veterinary animals.
Hypertonic sodium chloride solution. A solution having an osmotic pressure greater than that of physiologic salt solution (0.9 g NaCl in 100 ml purified water).
Delivery of drugs into an artery.
The fourth stomach of ruminating animals. It is also called the "true" stomach. It is an elongated pear-shaped sac lying on the floor of the abdomen, on the right-hand side, and roughly between the seventh and twelfth ribs. It leads to the beginning of the small intestine. (From Black's Veterinary Dictionary, 17th ed)
FATTY ACIDS found in the plasma that are complexed with SERUM ALBUMIN for transport. These fatty acids are not in glycerol ester form.
A branch of the celiac artery that distributes to the stomach, pancreas, duodenum, liver, gallbladder, and greater omentum.
Drugs used to cause dilation of the blood vessels.
Part of the arm in humans and primates extending from the ELBOW to the WRIST.
Inflammation of a vein, often a vein in the leg. Phlebitis associated with a blood clot is called (THROMBOPHLEBITIS).
Studies comparing two or more treatments or interventions in which the subjects or patients, upon completion of the course of one treatment, are switched to another. In the case of two treatments, A and B, half the subjects are randomly allocated to receive these in the order A, B and half to receive them in the order B, A. A criticism of this design is that effects of the first treatment may carry over into the period when the second is given. (Last, A Dictionary of Epidemiology, 2d ed)
The circulation of the BLOOD through the vessels of the KIDNEY.
The time it takes for a substance (drug, radioactive nuclide, or other) to lose half of its pharmacologic, physiologic, or radiologic activity.
Maintenance of a constant blood glucose level by perfusion or infusion with glucose or insulin. It is used for the study of metabolic rates (e.g., in glucose, lipid, amino acid metabolism) at constant glucose concentration.
Injections into the cerebral ventricles.
Process of administering an anesthetic through injection directly into the bloodstream.
Drugs used to cause constriction of the blood vessels.
A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain.
Solutions having the same osmotic pressure as blood serum, or another solution with which they are compared. (From Grant & Hackh's Chemical Dictionary, 5th ed & Dorland, 28th ed)
A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.
A process involving chance used in therapeutic trials or other research endeavor for allocating experimental subjects, human or animal, between treatment and control groups, or among treatment groups. It may also apply to experiments on inanimate objects.
Sodium excretion by URINATION.
The use of two or more chemicals simultaneously or sequentially in the drug therapy of neoplasms. The drugs need not be in the same dosage form.
An increase in the excretion of URINE. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations or by parent x offspring matings carried out with certain restrictions. This also includes animals with a long history of closed colony breeding.
The shortest and widest portion of the SMALL INTESTINE adjacent to the PYLORUS of the STOMACH. It is named for having the length equal to about the width of 12 fingers.
A statistical technique that isolates and assesses the contributions of categorical independent variables to variation in the mean of a continuous dependent variable.
Drugs used to induce drowsiness or sleep or to reduce psychological excitement or anxiety.
The transfer of lymphocytes from a donor to a recipient or reinfusion to the donor.
A potent narcotic analgesic, abuse of which leads to habituation or addiction. It is primarily a mu-opioid agonist. Fentanyl is also used as an adjunct to general anesthetics, and as an anesthetic for induction and maintenance. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1078)
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
A statistical means of summarizing information from a series of measurements on one individual. It is frequently used in clinical pharmacology where the AUC from serum levels can be interpreted as the total uptake of whatever has been administered. As a plot of the concentration of a drug against time, after a single dose of medicine, producing a standard shape curve, it is a means of comparing the bioavailability of the same drug made by different companies. (From Winslade, Dictionary of Clinical Research, 1992)
The physiological widening of BLOOD VESSELS by relaxing the underlying VASCULAR SMOOTH MUSCLE.
Compounds with activity like OPIATE ALKALOIDS, acting at OPIOID RECEPTORS. Properties include induction of ANALGESIA or NARCOSIS.
A short thick vein formed by union of the superior mesenteric vein and the splenic vein.
Drugs that block nerve conduction when applied locally to nerve tissue in appropriate concentrations. They act on any part of the nervous system and on every type of nerve fiber. In contact with a nerve trunk, these anesthetics can cause both sensory and motor paralysis in the innervated area. Their action is completely reversible. (From Gilman AG, et. al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed) Nearly all local anesthetics act by reducing the tendency of voltage-dependent sodium channels to activate.
The volume of BLOOD passing through the HEART per unit of time. It is usually expressed as liters (volume) per minute so as not to be confused with STROKE VOLUME (volume per beat).
The administration of medication by insertion of a tiny needle or catheter into the spinal sac or epidural cavity.
Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DIZZINESS but greater negative impacts on the body occur when there is prolonged depravation of oxygen and nutrients.
A powerful vasodilator used in emergencies to lower blood pressure or to improve cardiac function. It is also an indicator for free sulfhydryl groups in proteins.
A highly specific (Leu-Leu) endopeptidase that generates ANGIOTENSIN I from its precursor ANGIOTENSINOGEN, leading to a cascade of reactions which elevate BLOOD PRESSURE and increase sodium retention by the kidney in the RENIN-ANGIOTENSIN SYSTEM. The enzyme was formerly listed as EC 3.4.99.19.
The various ways of administering a drug or other chemical to a site in a patient or animal from where the chemical is absorbed into the blood and delivered to the target tissue.
A state characterized by loss of feeling or sensation. This depression of nerve function is usually the result of pharmacologic action and is induced to allow performance of surgery or other painful procedures.
A short-acting opioid anesthetic and analgesic derivative of FENTANYL. It produces an early peak analgesic effect and fast recovery of consciousness. Alfentanil is effective as an anesthetic during surgery, for supplementation of analgesia during surgical procedures, and as an analgesic for critically ill patients.
The circulation of blood through the CORONARY VESSELS of the HEART.
Any of various animals that constitute the family Suidae and comprise stout-bodied, short-legged omnivorous mammals with thick skin, usually covered with coarse bristles, a rather long mobile snout, and small tail. Included are the genera Babyrousa, Phacochoerus (wart hogs), and Sus, the latter containing the domestic pig (see SUS SCROFA).
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.
The main glucocorticoid secreted by the ADRENAL CORTEX. Its synthetic counterpart is used, either as an injection or topically, in the treatment of inflammation, allergy, collagen diseases, asthma, adrenocortical deficiency, shock, and some neoplastic conditions.
Treatment process involving the injection of fluid into an organ or tissue.
A family of hexahydropyridines.
The thoracolumbar division of the autonomic nervous system. Sympathetic preganglionic fibers originate in neurons of the intermediolateral column of the spinal cord and project to the paravertebral and prevertebral ganglia, which in turn project to target organs. The sympathetic nervous system mediates the body's response to stressful situations, i.e., the fight or flight reactions. It often acts reciprocally to the parasympathetic system.
A member of the alkali group of metals. It has the atomic symbol Na, atomic number 11, and atomic weight 23.
A strong corrosive acid that is commonly used as a laboratory reagent. It is formed by dissolving hydrogen chloride in water. GASTRIC ACID is the hydrochloric acid component of GASTRIC JUICE.
A catecholamine derivative with specificity for BETA-1 ADRENERGIC RECEPTORS. It is commonly used as a cardiotonic agent after CARDIAC SURGERY and during DOBUTAMINE STRESS ECHOCARDIOGRAPHY.
An alpha-1 adrenergic agonist used as a mydriatic, nasal decongestant, and cardiotonic agent.
A imidazole derivative that is an agonist of ADRENERGIC ALPHA-2 RECEPTORS. It is closely-related to MEDETOMIDINE, which is the racemic form of this compound.
The insertion of a tube into the stomach, intestines, or other portion of the gastrointestinal tract to allow for the passage of food products, etc.
The action of a drug that may affect the activity, metabolism, or toxicity of another drug.
A nucleoside that is composed of ADENINE and D-RIBOSE. Adenosine or adenosine derivatives play many important biological roles in addition to being components of DNA and RNA. Adenosine itself is a neurotransmitter.
Antidiuretic hormones released by the NEUROHYPOPHYSIS of all vertebrates (structure varies with species) to regulate water balance and OSMOLARITY. In general, vasopressin is a nonapeptide consisting of a six-amino-acid ring with a cysteine 1 to cysteine 6 disulfide bridge or an octapeptide containing a CYSTINE. All mammals have arginine vasopressin except the pig with a lysine at position 8. Vasopressin, a vasoconstrictor, acts on the KIDNEY COLLECTING DUCTS to increase water reabsorption, increase blood volume and blood pressure.
The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.
A free radical gas produced endogenously by a variety of mammalian cells, synthesized from ARGININE by NITRIC OXIDE SYNTHASE. Nitric oxide is one of the ENDOTHELIUM-DEPENDENT RELAXING FACTORS released by the vascular endothelium and mediates VASODILATION. It also inhibits platelet aggregation, induces disaggregation of aggregated platelets, and inhibits platelet adhesion to the vascular endothelium. Nitric oxide activates cytosolic GUANYLATE CYCLASE and thus elevates intracellular levels of CYCLIC GMP.
Salts or esters of LACTIC ACID containing the general formula CH3CHOHCOOR.
Pain during the period after surgery.
The concentration of osmotically active particles in solution expressed in terms of osmoles of solute per liter of solution. Osmolality is expressed in terms of osmoles of solute per kilogram of solvent.
The administering of nutrients for assimilation and utilization by a patient who cannot maintain adequate nutrition by enteral feeding alone. Nutrients are administered by a route other than the alimentary canal (e.g., intravenously, subcutaneously).
Use or insertion of a tubular device into a duct, blood vessel, hollow organ, or body cavity for injecting or withdrawing fluids for diagnostic or therapeutic purposes. It differs from INTUBATION in that the tube here is used to restore or maintain patency in obstructions.
A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
Sense of awareness of self and of the environment.
Forceful administration under the skin of liquid medication, nutrient, or other fluid through a hollow needle piercing the skin.
An essential amino acid that is physiologically active in the L-form.
A 14-amino acid peptide named for its ability to inhibit pituitary GROWTH HORMONE release, also called somatotropin release-inhibiting factor. It is expressed in the central and peripheral nervous systems, the gut, and other organs. SRIF can also inhibit the release of THYROID-STIMULATING HORMONE; PROLACTIN; INSULIN; and GLUCAGON besides acting as a neurotransmitter and neuromodulator. In a number of species including humans, there is an additional form of somatostatin, SRIF-28 with a 14-amino acid extension at the N-terminal.
The active metabolite of FOLIC ACID. Leucovorin is used principally as an antidote to FOLIC ACID ANTAGONISTS.
A hormone secreted by the ADRENAL CORTEX that regulates electrolyte and water balance by increasing the renal retention of sodium and the excretion of potassium.
Substances that dissociate into two or more ions, to some extent, in water. Solutions of electrolytes thus conduct an electric current and can be decomposed by it (ELECTROLYSIS). (Grant & Hackh's Chemical Dictionary, 5th ed)
Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.
A technique for measuring extracellular concentrations of substances in tissues, usually in vivo, by means of a small probe equipped with a semipermeable membrane. Substances may also be introduced into the extracellular space through the membrane.
Substances that inhibit or prevent the proliferation of NEOPLASMS.
The delivery of nutrients for assimilation and utilization by a patient whose sole source of nutrients is via solutions administered intravenously, subcutaneously, or by some other non-alimentary route. The basic components of TPN solutions are protein hydrolysates or free amino acid mixtures, monosaccharides, and electrolytes. Components are selected for their ability to reverse catabolism, promote anabolism, and build structural proteins.
Antibodies produced by a single clone of cells.
A potent natriuretic and vasodilatory peptide or mixture of different-sized low molecular weight PEPTIDES derived from a common precursor and secreted mainly by the HEART ATRIUM. All these peptides share a sequence of about 20 AMINO ACIDS.
The hollow, muscular organ that maintains the circulation of the blood.
Organic compounds that generally contain an amino (-NH2) and a carboxyl (-COOH) group. Twenty alpha-amino acids are the subunits which are polymerized to form proteins.
The range or frequency distribution of a measurement in a population (of organisms, organs or things) that has not been selected for the presence of disease or abnormality.
The principal alkaloid in opium and the prototype opiate analgesic and narcotic. Morphine has widespread effects in the central nervous system and on smooth muscle.
The relief of pain without loss of consciousness through the introduction of an analgesic agent into the epidural space of the vertebral canal. It is differentiated from ANESTHESIA, EPIDURAL which refers to the state of insensitivity to sensation.
The circulation of BLOOD through the LIVER.
A widely used local anesthetic agent.
A volatile vasodilator which relieves ANGINA PECTORIS by stimulating GUANYLATE CYCLASE and lowering cytosolic calcium. It is also sometimes used for TOCOLYSIS and explosives.
Therapy whose basic objective is to restore the volume and composition of the body fluids to normal with respect to WATER-ELECTROLYTE BALANCE. Fluids may be administered intravenously, orally, by intermittent gavage, or by HYPODERMOCLYSIS.
A subtype of striated muscle, attached by TENDONS to the SKELETON. Skeletal muscles are innervated and their movement can be consciously controlled. They are also called voluntary muscles.
The rate at which oxygen is used by a tissue; microliters of oxygen STPD used per milligram of tissue per hour; the rate at which oxygen enters the blood from alveolar gas, equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body. (Stedman, 25th ed, p346)
The amount of a substance secreted by cells or by a specific organ or organism over a given period of time; usually applies to those substances which are formed by glandular tissues and are released by them into biological fluids, e.g., secretory rate of corticosteroids by the adrenal cortex, secretory rate of gastric acid by the gastric mucosa.
A competitive inhibitor of nitric oxide synthetase.
A widely used non-cardioselective beta-adrenergic antagonist. Propranolol has been used for MYOCARDIAL INFARCTION; ARRHYTHMIA; ANGINA PECTORIS; HYPERTENSION; HYPERTHYROIDISM; MIGRAINE; PHEOCHROMOCYTOMA; and ANXIETY but adverse effects instigate replacement by newer drugs.
The transfer of leukocytes from a donor to a recipient or reinfusion to the donor.
Agents that have a strengthening effect on the heart or that can increase cardiac output. They may be CARDIAC GLYCOSIDES; SYMPATHOMIMETICS; or other drugs. They are used after MYOCARDIAL INFARCT; CARDIAC SURGICAL PROCEDURES; in SHOCK; or in congestive heart failure (HEART FAILURE).
Administration of a drug or chemical by the individual under the direction of a physician. It includes administration clinically or experimentally, by human or animal.
Any liquid used to replace blood plasma, usually a saline solution, often with serum albumins, dextrans or other preparations. These substances do not enhance the oxygen- carrying capacity of blood, but merely replace the volume. They are also used to treat dehydration.
The volume of water filtered out of plasma through glomerular capillary walls into Bowman's capsules per unit of time. It is considered to be equivalent to INULIN clearance.
Volume of circulating BLOOD. It is the sum of the PLASMA VOLUME and ERYTHROCYTE VOLUME.
The physiological narrowing of BLOOD VESSELS by contraction of the VASCULAR SMOOTH MUSCLE.
A cyclohexanone derivative used for induction of anesthesia. Its mechanism of action is not well understood, but ketamine can block NMDA receptors (RECEPTORS, N-METHYL-D-ASPARTATE) and may interact with sigma receptors.
A value equal to the total volume flow divided by the cross-sectional area of the vascular bed.
A trihydroxy sugar alcohol that is an intermediate in carbohydrate and lipid metabolism. It is used as a solvent, emollient, pharmaceutical agent, and sweetening agent.
Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.
A syndrome with excessively high INSULIN levels in the BLOOD. It may cause HYPOGLYCEMIA. Etiology of hyperinsulinism varies, including hypersecretion of a beta cell tumor (INSULINOMA); autoantibodies against insulin (INSULIN ANTIBODIES); defective insulin receptor (INSULIN RESISTANCE); or overuse of exogenous insulin or HYPOGLYCEMIC AGENTS.
The rate dynamics in chemical or physical systems.
Introduction of substances into the body using a needle and syringe.
The middle segment of proinsulin that is between the N-terminal B-chain and the C-terminal A-chain. It is a pancreatic peptide of about 31 residues, depending on the species. Upon proteolytic cleavage of proinsulin, equimolar INSULIN and C-peptide are released. C-peptide immunoassay has been used to assess pancreatic beta cell function in diabetic patients with circulating insulin antibodies or exogenous insulin. Half-life of C-peptide is 30 min, almost 8 times that of insulin.
The volume of packed RED BLOOD CELLS in a blood specimen. The volume is measured by centrifugation in a tube with graduated markings, or with automated blood cell counters. It is an indicator of erythrocyte status in disease. For example, ANEMIA shows a low value; POLYCYTHEMIA, a high value.
Abnormally high BLOOD GLUCOSE level.
A colorless, odorless gas that can be formed by the body and is necessary for the respiration cycle of plants and animals.
The circulation of blood through the BLOOD VESSELS supplying the abdominal VISCERA.
The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.
A small colorless crystal used as an anticonvulsant, a cathartic, and an electrolyte replenisher in the treatment of pre-eclampsia and eclampsia. It causes direct inhibition of action potentials in myometrial muscle cells. Excitation and contraction are uncoupled, which decreases the frequency and force of contractions. (From AMA Drug Evaluations Annual, 1992, p1083)
Isopropyl analog of EPINEPHRINE; beta-sympathomimetic that acts on the heart, bronchi, skeletal muscle, alimentary tract, etc. It is used mainly as bronchodilator and heart stimulant.
The predominant form of mammalian antidiuretic hormone. It is a nonapeptide containing an ARGININE at residue 8 and two disulfide-linked cysteines at residues of 1 and 6. Arg-vasopressin is used to treat DIABETES INSIPIDUS or to improve vasomotor tone and BLOOD PRESSURE.
A syndrome of abnormally low BLOOD GLUCOSE level. Clinical hypoglycemia has diverse etiologies. Severe hypoglycemia eventually lead to glucose deprivation of the CENTRAL NERVOUS SYSTEM resulting in HUNGER; SWEATING; PARESTHESIA; impaired mental function; SEIZURES; COMA; and even DEATH.
The consumption of edible substances.
A local anesthetic and cardiac depressant used as an antiarrhythmia agent. Its actions are more intense and its effects more prolonged than those of PROCAINE but its duration of action is shorter than that of BUPIVACAINE or PRILOCAINE.
Transmission of energy or mass by a medium involving movement of the medium itself. The circulatory movement that occurs in a fluid at a nonuniform temperature owing to the variation of its density and the action of gravity. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed; Webster, 10th ed)
Substances which lower blood glucose levels.
The highest dose of a biologically active agent given during a chronic study that will not reduce longevity from effects other than carcinogenicity. (from Lewis Dictionary of Toxicology, 1st ed)
The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.
A system of vessels in which blood, after passing through one capillary bed, is conveyed through a second set of capillaries before it returns to the systemic circulation. It pertains especially to the hepatic portal system.
An element with the atomic symbol N, atomic number 7, and atomic weight [14.00643; 14.00728]. Nitrogen exists as a diatomic gas and makes up about 78% of the earth's atmosphere by volume. It is a constituent of proteins and nucleic acids and found in all living cells.
Abstaining from all food.
The giving of drugs, chemicals, or other substances by mouth.
An unpleasant sensation in the stomach usually accompanied by the urge to vomit. Common causes are early pregnancy, sea and motion sickness, emotional stress, intense pain, food poisoning, and various enteroviruses.
A neurotransmitter found at neuromuscular junctions, autonomic ganglia, parasympathetic effector junctions, a subset of sympathetic effector junctions, and at many sites in the central nervous system.
Agents obtained from higher plants that have demonstrable cytostatic or antineoplastic activity.
A cyclodecane isolated from the bark of the Pacific yew tree, TAXUS BREVIFOLIA. It stabilizes MICROTUBULES in their polymerized form leading to cell death.
The transference of BONE MARROW from one human or animal to another for a variety of purposes including HEMATOPOIETIC STEM CELL TRANSPLANTATION or MESENCHYMAL STEM CELL TRANSPLANTATION.
The muscle tissue of the HEART. It is composed of striated, involuntary muscle cells (MYOCYTES, CARDIAC) connected to form the contractile pump to generate blood flow.
A diuretic and renal diagnostic aid related to sorbitol. It has little significant energy value as it is largely eliminated from the body before any metabolism can take place. It can be used to treat oliguria associated with kidney failure or other manifestations of inadequate renal function and has been used for determination of glomerular filtration rate. Mannitol is also commonly used as a research tool in cell biological studies, usually to control osmolarity.
The treatment of a disease or condition by several different means simultaneously or sequentially. Chemoimmunotherapy, RADIOIMMUNOTHERAPY, chemoradiotherapy, cryochemotherapy, and SALVAGE THERAPY are seen most frequently, but their combinations with each other and surgery are also used.
Biosynthesis of GLUCOSE from nonhexose or non-carbohydrate precursors, such as LACTATE; PYRUVATE; ALANINE; and GLYCEROL.
Preliminary administration of a drug preceding a diagnostic, therapeutic, or surgical procedure. The commonest types of premedication are antibiotics (ANTIBIOTIC PROPHYLAXIS) and anti-anxiety agents. It does not include PREANESTHETIC MEDICATION.
Proteins prepared by recombinant DNA technology.
Nutritional support given via the alimentary canal or any route connected to the gastrointestinal system (i.e., the enteral route). This includes oral feeding, sip feeding, and tube feeding using nasogastric, gastrostomy, and jejunostomy tubes.
Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction.
A compound formed in the liver from ammonia produced by the deamination of amino acids. It is the principal end product of protein catabolism and constitutes about one half of the total urinary solids.
A short-acting hypnotic-sedative drug with anxiolytic and amnestic properties. It is used in dentistry, cardiac surgery, endoscopic procedures, as preanesthetic medication, and as an adjunct to local anesthesia. The short duration and cardiorespiratory stability makes it useful in poor-risk, elderly, and cardiac patients. It is water-soluble at pH less than 4 and lipid-soluble at physiological pH.
A general class of ortho-dihydroxyphenylalkylamines derived from tyrosine.
An element in the alkali group of metals with an atomic symbol K, atomic number 19, and atomic weight 39.10. It is the chief cation in the intracellular fluid of muscle and other cells. Potassium ion is a strong electrolyte that plays a significant role in the regulation of fluid volume and maintenance of the WATER-ELECTROLYTE BALANCE.
An essential branched-chain amino acid important for hemoglobin formation.
An outbred strain of rats developed in 1915 by crossing several Wistar Institute white females with a wild gray male. Inbred strains have been derived from this original outbred strain, including Long-Evans cinnamon rats (RATS, INBRED LEC) and Otsuka-Long-Evans-Tokushima Fatty rats (RATS, INBRED OLETF), which are models for Wilson's disease and non-insulin dependent diabetes mellitus, respectively.
Drugs that selectively bind to and activate alpha adrenergic receptors.
The period of emergence from general anesthesia, where different elements of consciousness return at different rates.
Relief of PAIN, without loss of CONSCIOUSNESS, through ANALGESIC AGENTS administered by the patients. It has been used successfully to control POSTOPERATIVE PAIN, during OBSTETRIC LABOR, after BURNS, and in TERMINAL CARE. The choice of agent, dose, and lockout interval greatly influence effectiveness. The potential for overdose can be minimized by combining small bolus doses with a mandatory interval between successive doses (lockout interval).
An antineoplastic antimetabolite that is metabolized to fluorouracil when administered by rapid injection; when administered by slow, continuous, intra-arterial infusion, it is converted to floxuridine monophosphate. It has been used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract.
An inorganic and water-soluble platinum complex. After undergoing hydrolysis, it reacts with DNA to produce both intra and interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity of cisplatin correlates with cellular arrest in the G2 phase of the cell cycle.
The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
Antimetabolites that are useful in cancer chemotherapy.
A decrease in the number of NEUTROPHILS found in the blood.
The decrease in a measurable parameter of a PHYSIOLOGICAL PROCESS, including cellular, microbial, and plant; immunological, cardiovascular, respiratory, reproductive, urinary, digestive, neural, musculoskeletal, ocular, and skin physiological processes; or METABOLIC PROCESS, including enzymatic and other pharmacological processes, by a drug or other chemical.
Small-scale tests of methods and procedures to be used on a larger scale if the pilot study demonstrates that these methods and procedures can work.
Organic compounds which contain platinum as an integral part of the molecule.
An opioid analgesic that is used as an adjunct in anesthesia, in balanced anesthesia, and as a primary anesthetic agent.
The calcium salt of gluconic acid. The compound has a variety of uses, including its use as a calcium replenisher in hypocalcemic states.
Progressive diminution of the susceptibility of a human or animal to the effects of a drug, resulting from its continued administration. It should be differentiated from DRUG RESISTANCE wherein an organism, disease, or tissue fails to respond to the intended effectiveness of a chemical or drug. It should also be differentiated from MAXIMUM TOLERATED DOSE and NO-OBSERVED-ADVERSE-EFFECT LEVEL.
Disease having a short and relatively severe course.
Oil from soybean or soybean plant.

Hydromorphone efficacy and treatment protocol impact on tolerance and mu-opioid receptor regulation. (1/149)

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Granulocyte-colony stimulating factor improves outcome in a mouse model of amyotrophic lateral sclerosis. (2/149)

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Continuous administration of the somatostatin structural derivative /TT-232/ by subcutaneously implanted osmotic pump improves the efficacy and potency of antitumor therapy in different mouse and human tumor models. (3/149)

BACKGROUND: The somatostatin structural derivative, TT-232, has a special 5-residue ring structure (D-Phe-Cys-Tyr-D-Trp-Lys-Cys-Thr-NH2) and very different characteristics from the known growth hormone (GH) active somatostatin analogs. This somatostatin structural derivative has no GH release inhibitory or antisecretory activity and does not bind to rat pituitary or the cortex, where all the known somatostatin receptor subtypes are expressed. TT-232 had previously been shown to inhibit the proliferation of a large number of cancer cell lines in vitro and reduce the size of different tumors in animal models in vivo. MATERIALS AND METHODS: The therapeutic efficacy of TT-232 was evaluated in different long-term administration routes: the traditional injection (i.p. or s.c.) versus infusion treatment via s.c.- or i.v.-inserted Alzet osmotic minipump, and on different types of transplantable rodent (S-180 sarcoma, P-388sc lymphoid leukemia, Colon-26 adenocarcinoma, MXT breast carcinoma, B-16 melanoma) and human tumor models (HT-18 lymphoid melanoma, T-47/D breast carcinoma, A-431 epidermoid carcinoma). On the basis of our previous experiments the optimum injected dose of TT-232 was found to be 15 microg/kg twice a day. This dose is equivalent to 0.6 dg/day by infusion therapy. RESULTS: In our experiments, the best results were achieved when TT-232 was applied as an infused treatment. In the S-180 sarcoma and P-388sc lymphoid leukemia rodent tumor models the infusion treatment with TT-232 resulted in 61%-100% tumor growth inhibition and in 20%-60% of the mice being long-term and tumor-free survivors. In the aggressive Colon-26 adenocarcinoma and MXT breast carcinoma models, the infusion treatment resulted in 52%-75% tumor growth inhibition. In the B-16 melanoma model, the infusion treatments resulted in 47% -63% growth inhibition. The tumor growth inhibitory effect of infusion treatment with TT-232 on HT-18 human lymphoid melanoma tumor proved to be significant, resulting in 69%-79% decreases in tumor volume. In the T-47/D human breast carcinoma, the infusion treatment resulted in 48%-53% tumor growth inhibition. The tumor growth inhibitory effect of infusion treatment on A-431 human epidermoid carcinoma tumor resulted in 70%-74% decreases in tumor volume. CONCLUSION: The antitumor efficacy of TT-232 was seen in almost all the tumors investigated. In our study, the route of infusion was shown to increase drug efficacy relative to conventional delivery methods (injection). The results obtained from this study suggest that TT-232 is a promising new antitumor agent in cancer chemotherapy and a good candidate for delivery by continuous (infusion) therapy.  (+info)

Behavioral effects of systemic transforming growth factor-alpha in Syrian hamsters. (4/149)

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A phase I/II study of rituximab and etanercept in patients with chronic lymphocytic leukemia and small lymphocytic lymphoma. (5/149)

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Evidence for angiotensin-converting enzyme 2 as a therapeutic target for the prevention of pulmonary hypertension. (6/149)

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Recombinant human relaxin in the treatment of systemic sclerosis with diffuse cutaneous involvement: a randomized, double-blind, placebo-controlled trial. (7/149)

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Enhancement of lung carcinogenesis initiated with 4-(N-hydroxymethylnitrosamino)-1-(3-pyridyl)-1-butanone by Ogg1 gene deficiency in female, but not male, mice. (8/149)

The present study was conducted to assess involvement of oxidative stress in lung adeno-carcinogenesis, using mice deficient in the 8-hydroxyguanine DNA glycosylase 1 (Ogg1) gene encoding an enzyme that repairs an oxidative DNA injury 8-oxoguanine (8-oxoG). Furthermore, for comparison with the human case, mutations of mouse epidermal growth factor receptor (Egfr) and K-ras genes were examined. The homo- and heterozygously Ogg1 gene-deficient and wild-type mice (C57BL6/J origin), 6 weeks old, were administered 4-(N-hydroxymethylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) by continuous subcutaneous infusion using an osmotic pump at a total dose of 6 mg/mouse for 1 week, then treated with one of 4 antioxidants (phenyl N-tert-butyl nitrone 0.13% in drinking water, resveratrol 20 ppm in diet, lactoferrin 2% in diet and bilberry powder 2% in diet) or no supplement for 33 weeks. Development of lung adenomas and preneoplastic atypical hypreplasias was significantly enhanced by the homo- and heterozygous Ogg1 gene deficiency only in female mice with intralesion accumulation of 8-oxoG. All antioxidants tended to inhibit enhanced adeno-carcinogenesis. The Egfr and K-ras gene mutations were detected at sites also found in human lung cancers with low incidences, while the Egfr gene mutation was detected for the first time in chemical lung carcinogenesis of animals. It is indicated that the Ogg1 gene deficiency enhances lung adeno-carcinogenesis in mice by virtue of accelerated oxidative stress. The presently utilized Ogg1 gene-deficient mice model may be useful to draw mechanism-based strategies to control human lung adenocarcinomas, especially in women.  (+info)

Blair, Jo, Gregory, John W and Peak, Matthew (2012) Insulin delivery by multiple daily injections or continuous subcutaneous insulin infusion in childhood: Addressing the evidence gap. Practical Diabetes, 29 (2). pp. 47-48. ISSN 2047-2900 ...
OBJECTIVE: The purpose of this study is to determine whether parental knowledge of the continuous subcutaneous insulin infusion (CSII) device affects glycemic control as measured by hemoglobin A1c (A1C) level. SUBJECTS AND METHODS: Parents of children with type 1 diabetes mellitus (T1DM) using CSII completed a 14-item questionnaire. Questions 1-10 were knowledge-based questions that required the parent to extract specific information from their childs CSII device. Questions 11-14 asked parents to provide a self-assessment of their CSII knowledge. RESULTS: Twenty-two parents of youth with T1DM participated in the study. Ten of the youth were in the Low-A1C group (A1C/=8%). Parents of youth in the Low-A1C group scored statistically better on the 10-item performance survey than parents of youth in the High-A1C group. Most of the parents of children in the Low-A1C group responded that they knew their childs insulin pump very well and that their pump knowledge had increased since their child started on
To estimate the incremental cost-effectiveness ratio (ICER) of the use of continuous subcutaneous insulin infusion (CSII) therapy versus multiple daily injections (MDI) therapy in adult patients with type 1 diabetes (T1D) at the Mexican Institute of Social Security (IMSS). An analysis was developed using the internationally validated Core Diabetes Model (CDM) with which the incidence and progression of acute and chronic complications and the mortality of T1D was simulated throughout life. The baseline characteristics of the simulated cohorts were obtained from Mexican T1D adult patients aged ≥ 18 years that received care at two national IMSS medical centres in 2016. In the base case, the costs of the complications and treatment of the disease with both therapies were estimated in Mexican currency from the perspective of the institution, using Diagnosis Related Groups for outpatient and inpatient care. Utilities were taken from the international bibliography. In a secondary analysis, indirect costs
Intensive glucose control (3 or more daily insulin injections or continuous subcutaneous insulin infusion) reduced the mean risk of retinopathy progression by 54% in type 1 diabetes patients with minimal-to-moderate…
Continuous subcutaneous insulin infusion (CSII) is one of the ways to control blood glucose for prolonged periods. This study was undertaken to establish the long-term feasibility and efficacy of CSII with patient self-management. Patients were instructed to maintain their calorie and carbohydrate i …
AbstractThe aim of this study was to quantify the impact of treatment of hypoglycaemia-prone type 1 diabetic subjects by continuous subcutaneous insulin infusion (CSII). A prospective analysis was carried out in patients attending a specialist insulin pump clinic. Type 1 diabetic patients (n=27) who
The incidence of low nocturnal blood glucose values (i.e., less than 65 mg/dl) was assessed in 20 insulin-dependent diabetic patients treated with continuous subcutaneous insulin infusion supported by capillary blood glucose monitoring before each meal and the evening snack. Patients were randomly a …
This guidance represents the view of the Institute which was arrived at after careful consideration of the available evidence. Health professionals are expected to fully take it into account when exercising their clinical judgement. This guidance does not, however, override the individual responsibility of health professionals to make appropriate decisions in the circumstances of the individual patient, in consultation with the patient and/or guardian or carer.. © Copyright National Institute for Health and Care Excellence. All rights reserved. This material may be freely reproduced for educational and not for profit purposes within the NHS. No reproduction by or for commercial organisations is permitted without the express written permission of the Institute.. Enquiries concerning the guidance should be addressed to: National Institute for Health and Care Excellence, MidCity Place, 71 High Holborn, London WC1V 6NA. email: [email protected] Continuous Subcutaneous Insulin Infusion for the ...
TY - JOUR. T1 - EMPLOYING CONTINUOUS SUBCUTANEOUS INSULIN INFUSION THERAPY IN THE OPERATING SUITE. T2 - CURRENT STATE AND FUTURE DIRECTIONS. AU - Thompson, Bithika M.. AU - Cook, Curtiss B.. PY - 2015/11/1. Y1 - 2015/11/1. UR - http://www.scopus.com/inward/record.url?scp=84979988065&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=84979988065&partnerID=8YFLogxK. U2 - 10.4158/EP15974.CO. DO - 10.4158/EP15974.CO. M3 - Comment/debate. C2 - 26484406. AN - SCOPUS:84979988065. VL - 21. SP - 1306. EP - 1308. JO - Endocrine Practice. JF - Endocrine Practice. SN - 1530-891X. IS - 11. ER - ...
Participants first received 0.12 units per kilogram (U/kg) insulin aspart administered as a continuous subcutaneous insulin infusion (CSII), for 5 days (Days 1-5; Period 1), including during a 6-hour (hr) euglycemic clamp on Days 2, 3, and 5. On Day 2 only, a sham injection was administered 2.5 hr prior to the 6-hr euglycemic clamp.. After a 5- to 14-day washout period, participants received 0.12 U/kg insulin aspart administered as a CSII, for 5 days (Days 6-10; Period 2), including during a 6-hr euglycemic clamp on Days 7, 8, and 10. On Day 7 only, a 1.0 milliliter (mL) subcutaneous (SC) injection of 1.25 micrograms per milliliter (μg/mL) recombinant human hyaluronidase PH20 (rHuPH20) was administered 2.5 hr prior to the 6-hr euglycemic clamp.. ...
Participants first received 0.12 units per kilogram (U/kg) insulin aspart administered as a continuous subcutaneous insulin infusion (CSII), for 5 days (Days 1-5; Period 1), including during a 6-hour (hr) euglycemic clamp on Days 2, 3, and 5. On Day 2 only, a sham injection was administered 2.5 hr prior to the 6-hr euglycemic clamp.. After a 5- to 14-day washout period, participants received 0.12 U/kg insulin aspart administered as a CSII, for 5 days (Days 6-10; Period 2), including during a 6-hr euglycemic clamp on Days 7, 8, and 10. On Day 7 only, a 1.0 milliliter (mL) subcutaneous (SC) injection of 1.25 micrograms per milliliter (μg/mL) recombinant human hyaluronidase PH20 (rHuPH20) was administered 2.5 hr prior to the 6-hr euglycemic clamp.. ...
Jonathan Burdick, H. Peter Chase, Robert H. Slover, Kerry Knievel, Laura Scrimgeour, Aristides K. Maniatis, Georgeanna J. Klingensmith ...
Thank you for your interest in spreading the word about Diabetes Care.. NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.. ...
Whereas inducing sustained hyperinsulinemia via peripheral insulin delivery decreases insulin sensitivity in people without type 1 diabetes, reducing hyperinsulinemia via portal insulin delivery increases insulin sensitivity in people with type 1 diabetes.. In the early 1990s, Shishko et al. (44) divided 12 patients with poorly controlled type 1 diabetes to receive either continuous subcutaneous insulin infusion (CSII) or intraportal insulin infusion (IPII) via the umbilical vein for 4 months. While the 24-h serum insulin and plasma glucose profiles of patients receiving IPII approximated that of matched control subjects without diabetes, patients receiving CSII had two- to threefold higher peripheral insulin concentrations and 50% higher glucose levels. Additionally, the mean total daily insulin dose was 20% lower in the IPII group compared with the CSII group. Although IPII participants had lower doses and serum levels of insulin compared with CSII participants, glycosylated hemoglobin dropped ...
Continuous subcutaneous insulin infusion (CSII) is a valuable option for patients with type 2 diabetes in whom glycemic targets are not met despite multiple daily injections (MDIs) at high insulin doses, as recently demonstrated in the multicenter randomized OpT2mise trial (1). However, data on the durability of glucose control with CSII are lacking (1,2). We report here the long-term efficacy of CSII in a cohort of 161 patients (51% female) with type 2 diabetes who started pump therapy between 1998 and 2012. The patients mean age was 58.3 ± 9.8 years, and mean BMI was 33.2 ± 6.6 kg/m2. The mean duration of diabetes was 15 ± 8.1 years, and mean glycated hemoglobin (HbA1c) was 9.0 ± 1.7% (74 ± 18.6 mmol/mol). At baseline, 96% of patients were receiving insulin: 48% were receiving basal-bolus regimens, 37% were receiving premixed MDI, and 11% were receiving only basal insulin. The mean duration of insulin treatment was 6.8 ± 4.6 years, and the mean total daily dose was 1.2 ± 0.9 units/kg. ...
An appraisal of a 2010 systematic review of continuous subcutaneous insulin infusion (CSII, or insulin pumps) has been published in DARE. Research question: In diabetes, does CSII as compared with multiple daily injections (MDI), improve the clinical or cost-effectiveness of care? The review included both adults and children with type 1 or type 2 diabetes. [read the full story…]. ...
Borderline diabetes: A term formerly used to mean mild or early diabetes; it is no longer used.. Carbohydrate counting: Estimating the amount of carbohydrate in food in order to determine insulin needs.. Carbohydrate: One of the three major energy sources - the one usually found in grain, fruits, and vegetables, and the one most responsible for raising the blood glucose.. Cataract: A clouding of the lens of the eye often found earlier and more commonly in people with diabetes.. Charcots foot: Destruction of joints and soft tissue in the foot leading to an unusable foot as a result of diabetic neuropathy.. Cholesterol: A form of fat that is needed in the body for production of certain hormones. It can lead to atherosclerosis if present in excessive levels. Butter and egg yolks are high in cholesterol.. Continuous subcutaneous insulin infusion (CSII): Continuous delivery of insulin under the skin, usually by an insulin pump, to mimic the way the body provides insulin.. Conventional diabetes ...
Improved glycaemic control and reduced risk for hypoglycaemia in patients with type 1 diabetes treated by continuous subcutaneous insulin infusion as compared to multiple daily insulin injections / vorgelegt von Stefanie Isabelle Kündig. - Zürich, 2009 ZB (Zürich) , UnS 2009: 841 , Magazin 05 - auf ...
Monarchs EndoTool® SubQ to feature optional insulin-on-board (IOB) calculation for subcutaneous insulin to mitigate the risk of hypoglycemia. Learn more.
...SAN MATEO Calif. Oct. 18 2011 /- Nile Therapeutics In...The Phase I clinical trial was a placebo-controlled study evaluating P...In September Nile added a Part C to the trial with an objective to c... We achieved our objectives for this trial which was to determine dos...,Nile,Therapeutics,Completes,Dosing,of,Clinical,Trial,Evaluating,the,Subcutaneous,Infusion,of,Cenderitide,in,Chronic,Heart,Failure,Patients,medicine,advanced medical technology,medical laboratory technology,medical device technology,latest medical technology,Health
An injector device has a plunger with a medical needle essentially non-detachably secured thereto, preferably a solid needle incapable of delivering a fluid, and is adapted for the quick and easy tran
Humulin R U is a concentrated human insulin indicated to improve glycemic control in adults and children with diabetes mellitus requiring more than units of insulin per day.. Limitations of Use: The safety and efficacy of Humulin R U used in combination with other insulins, or when delivered by continuous subcutaneous infusion, has not been determined.. Jan 25, · Humulin R (insulin human recombinant) U is a sterile, clear, aqueous, and colorless solution that contains human insulin (rDNA origin) units/mL, glycerin 16 mg/mL and metacresol mg/mL, endogenous zinc (approximately mg/ units) and water for injection. humulin r (u) information for the physician. warnings. this lilly human insulin product differs from animal-source insulins because it is structurally identical to the insulin produced by your bodys pancreas and because of its unique manufacturing process. Nov 15, · Each milliliter of HUMULIN R also contains glycerin 16 mg, metacresol mg, endogenous zinc (approximately mg/ units,) and ...
LEMTRADA®, because of its risks, is generally for relapsing MS patients who have tried 2 or more MS medicines that didnt work well enough.
Things of course, have changed. The advent of over-the-counter glucose monitoring devices rather than double voided urine specimens alone as a tool to determine sliding scale insulin doses, has revolutionized the treatment of Type I diabetes. Good and complete studies have also indicated that very tight and intensive glucose control of adults and children with Type I diabetes can result in their having the same life expectancy as the rest of us. Insulin pumps dont take the job of endocrinologists and educated and well trained diabetics, but they can help to provide much better control and therefore a much better life than the autoimmune diabetic could have had otherwise. An insulin pump works by providing a subcutaneous infusion of a basal rate of insulin hourly. It is ideally the amount of insulin that the patient needs to live if she doesnt eat at all. Then,a calculated bolus doses of insulin can be dialed in to cover food. These are called meal boluses. This does not free the patient to eat ...
Hi Just picked up on this thread...late as ever! I was dx with PCOS whildt trying for a pregnancy about 13years ago. I had endometriosis and underactive thyroid, too. But certainly wasnt overweight as you would imagine (and as i had been led to believe I would be with this condition)! I had all the other symptoms of PCOS, though, including ovaries the size of oranges and had a wedge resection as an emergency (Dont think they do this now). The endo was more of a problem, although the PCOS meant I didnt have a menstrual cycle as such. Periods came as and when they decided! Sometimes 2 weeks, sometimes 3 months and the all time record of 18months in between! The endo meant they were absolute agony and extremely heavy and I was admitted to hospital on more than occassion. My hypos also increased at this time. This went on for a loooooooong time...all my teenage years from day one really. I did go on the pill for many years as this at least regulated things out although thats all it did. I ...
Immunotherapy of tumours using T cells expanded in vitro has met with mixed clinical success suggesting that a greater understanding of tumour/T-cell interaction is required. We used a HPV16E7 oncoprotein based mouse tumour model to study this further. In this study, we demonstrate that a HPV16E7 tumour passes through at least three stages of immune susceptibility over time. At the earliest time point, infusion of intravenous immune cells fails to control tumour growth although the same cells given subcutaneously at the tumour site are effective. In a second stage, the tumour becomes resistant to subcutaneous infusion of cells but is now susceptible to both adjuvant activated and HPV16E7-specific immune cells transferred intravenously. In the last phase, the tumour is susceptible to intravenous transfer of HPV16E7-specific cells, but not adjuvant-activated immune cells. The requirement for IFN-γ and perforin also changes with each stage of tumour development. Our data suggest that effective ...
Hartmanns | Lactated Ringers Solution (LRS) is a sterile intravenous or subcutaneous infusion, enteral fluid replacement or wound and eyewash.
Diabetes Relief is a patented Metabolic Activation Therapy. The protocol consists of a minimum of 10 sessions of pulsatile insulin infusion treatments to retrain the signaling and communication of pancreas and liver and restore metabolic function.
NSMCs state-of-the-art infusion center offers infusion therapy and infusion treatments for a range of conditions such as MS and Crohns Disease.
TY - JOUR. T1 - Insulin pump therapy. T2 - A meta-analysis. AU - Weissberg-Benchell, Jill. AU - Antisdel-Lomaglio, Jeanne. AU - Seshadri, Roopa. PY - 2003/4/1. Y1 - 2003/4/1. N2 - OBJECTIVE - To conduct a meta-analysis of the metabolic and psychosocial impact of continuous subcutaneous insulin infusion (CSII) therapy on adults, adolescents, and children. RESEARCH DESIGN AND METHODS - Studies were identified and data regarding study design, year of publication, sample size, patients age, diabetes duration, and duration of CSII therapy were collected. Means and SDs for glycohemoglobin, blood glucose, insulin dosages, and body weight for CSII and comparison conditions were subjected to meta-analytic procedures. Data regarding pump complications and psychosocial functioning were reviewed descriptively. RESULTS - A total of 52 studies, consisting of 1,547 patients, were included in the metaanalysis. Results indicate that CSII therapy is associated with significant improvements in glycemic control ...
A device for inserting a cannula of a subcutaneous infusion device into a subcutaneous layer of skin of a patient. For example, some devices automatically retract a needle used to introduce the cannula of a subcutaneous infusion device into the subcutaneous layer of skin of a patient. The device can include a housing with an internal cavity, as well as a needle coupled to the housing. The needle can be coupled to a cannula of a subcutaneous infusion device. A member can move the needle. Upon full introduction of the needle and associated cannula of the subcutaneous infusion device into a subcutaneous layer of skin of a patient, the member is automatically actuated to move the needle into the internal cavity of the housing into the retracted state while leaving the cannula of the subcutaneous infusion device in the subcutaneous layer of skin of the patient.
Continuous subcutaneous insulin infusion (CSII) is associated with increased hypoglycemia encounters and health care expenditures, according to research published in the American Journal of Managed Care (June 21, 2017;23[6]).. -----. Related Content. Insulin pathways and cost estimates included in new ADA Standards for diabetes care. Some elderly diabetes patients face high drug costs. -----. CSII-commonly referred to as insulin pump therapy-is an alternative to multiple daily insulin injections (MDII) for diabetes management. Prior research has reported some potential advantages of CSII over MDII therapy, such as reduced pain, less stigma, lower frequency of hypoglycemia, and overcoming adherence barriers. Limited data exists regarding whether the higher upfront costs for CSII can be offset by health improvements that translate to higher quality of life and lower utilization of health care services.. Ronald T Ackermann, MD, MPH, Northwestern Medicine (Chicago, IL), and colleagues conducted a ...
U-Needle is proud to announce it has recently joined forces with Inreda Diabetic and the University of Twente to develop the worlds first Microneedle Artificial Pancreas (MAP). In the MAP project the advanced AP technology of Inreda Diabetic, the intradermal administration technology of U-Needle and the sensor expertise of the University of Twente are brought together. The project aims to administer insulin and glucagon much faster than currently used Continuous Subcutaneous Insulin Infusion (CSII) systems, reducing postprandial peaks and obtaining an improved time-in-range. In order to do this, the commonly used subcutaneous infusion set that gives a relatively slow uptake will be replaced with a much faster intradermal infusion set, creating a new Continuous Intradermal Insulin (and Glucagon) Infusion system. It is believed this will eliminate the need for manual glucose management, even during meals.. Intradermal infusion as well as the use of Glucagon (next to Insulin) in AP systems have ...
Insulin therapy is the mainstay of medical management of type 1 diabetes. A variety of insulin regimens can be used, but few have been studied specifically in children with new-onset diabetes. The choice of insulin regimen depends on many factors, including the childs age, duration of diabetes, family lifestyle, socioeconomic factors, and family, patient, and physician preferences. Regardless of the insulin regimen used, all children should be treated to meet glycemic targets.. The honeymoon period, which can last up to 2 years after diagnosis, is characterized by good glycemic control and low insulin requirements (,0.5 units/kg/day). At the end of this period, more intensive management may be required to continue meeting glycemic targets. Two methods of intensive diabetes management have been used: basal-bolus regimens (long-acting basal insulin analogues and rapid-acting bolus insulin analogues) and continuous subcutaneous insulin infusion (CSII; insulin pump therapy). Basal-bolus therapy has ...
This page includes the following topics and synonyms: Hourly Subcutaneous Insulin, Hourly Subcutaneous Insulin Aspart, Hourly Subcutaneous Insulin Lispro.
Pump therapy is also known as continuous subcutaneous insulin infusion (CSII) and is an alternative way of giving insulin. A pump is a small device which delivers insulin in small frequent pulses. Rather than taking your usual 4-5 daily injections, insulin from the pump is delivered through a soft cannula which sits just under the skin. This is changed every 2-3 days. Unlike injections when you have your background or long acting insulin (such as Lantus or Levemir) plus rapid acting insulin for food (such as Novorapid or Humalog), pumps only run on rapid acting insulin. The pump is programmed with a background or basal rate, which can be altered every hour to meet your changing insulin needs over the 24 hours. This drips in slowly every few minutes. The pump is also programmed with other information specific to you including you such as your insulin to carbohydrate ratios for your meals and your correction factor.. The pump should be worn at all times however it is recommended to take it ...
Purpose and Research Objectives. Despite the availability of increasingly effective treatment modalities, including insulin analogues, continuous glucose monitors (CGMs), and continuous subcutaneous insulin infusion (CSII) devices, a substantial proportion of patients with type 1 diabetes (T1D) cannot achieve adequate glycemic control and avoid acute complications such as hypoglycemia. NIDDK has long supported this area of research, especially through small business projects, and this support has contributed substantially to the development of new devices that are increasingly used in clinical practice. Nonetheless, the approved devices and current technologies still have significant limitations, and it is important to put renewed emphasis on the creation of the next generation of devices that will further the goals of relieving patients of the burden of diabetes self-management and achieving daily euglycemia to prevent acute and chronic complications. Several relevant projects have been ...
Continuous Subcutaneous Insulin Infusion (CSII) pump therapy improves blood glucose control and lifestyle flexibility as compared to multiple-daily insulin injections. Yet less than half of people with type 1 diabetes currently use a pump and fewer use a companion continuous glucose monitoring (CGM) sensor. More convenient, reliable systems are needed to realize the promise of an artificial pancreas that reduces the daily burden of diabetes.. ...
Psychometric analysis of the Spanish and Catalan versions of the Diabetes Self-Care Inventory-Revised version questionnaire Margarida Jansà,1 Mercè Vidal,1 Marga Giménez,1 Ignacio Conget,1 Mercedes Galindo,2 Daria Roca,1 Cristina Colungo,3 Enric Esmatjes,1 Manel Salamero4 1Diabetes Unit, Endocrinology and Nutrition, Hospital Clinic, Barcelona, 2Endocrinology and Nutrition Department, Hospital Clinico, Madrid, 3Primary Care Centre, Hospital Clinic, Barcelona, 4Psychology Department, Hospital Clinic, Barcelona, Spain Background: The purpose of this study was to validate the Spanish and Catalan versions of the Diabetes Self-Care Inventory-Revised Version (SCI-R) questionnaire to assess the degree of adherence to self-care among adults with diabetes. Methods: We validated the Spanish and Catalan translation from, and back translation to, English and cultural adaptation of the SCI-R in type 1 diabetes patients on multiple insulin doses or continuous subcutaneous insulin infusion and in
iNDiGO is a 16-week, international, multicenter, randomized, double-blind, placebo controlled, parallel group study designed to compare the efficacy, safety and tolerability of continuous subcutaneous infusion of adjunct ND0612L therapy with oral standard-of-care and placebo in patients who suffer from motor fluctuations despite optimized standard-of-care therapy. Patients will be randomized to receive either continuous subcutaneous infusion of ND0612L or a placebo replaced every 24 hours during the 16-week treatment period. The primary endpoint is the change from baseline to week 16 in the mean percentage of OFF time, defined as periods of motor fluctuations that result in decreased mobility during waking hours, based on patients home diary assessments.. While the original trial design anticipated enrolling 200-240 patients, the company reduced this number to 150 patients following sample size calculations using the expected treatment effect and variability as well as those observed in a ...
Several literature reports indicate that morphine administered subcutaneously during the early gestational period in mice and hamsters produced neurological, soft tissue and skeletal abnormalities. With one exception, the effects that have been reported were following doses that were maternally toxic and the abnormalities noted were characteristic of those observed when maternal toxicity is present. In one study, following subcutaneous infusion of doses greater than or equal to 0.15 mg/kg to mice, exencephaly, hydronephrosis, intestinal hemorrhage, split supraoccipital, malformed sternebrae, and malformed xiphoid were noted in the absence of maternal toxicity. In the hamster, morphine sulfate given subcutaneously on gestation day 8 produced exencephaly and cranioschisis. In rats treated with subcutaneous infusions of morphine during the period of organogenesis, no teratogenicity was observed. No maternal toxicity was observed in this study, however, increased mortality and growth retardation ...
(HealthDay) -- The hypoglycemia-hyperglycemia minimizer (HHM) system, which includes a continuous, subcutaneous insulin infusion pump, continuous glucose monitor (CGM), and software, is able to predict changes in blood glucose ...
A 4-mg subcutaneous bolus of midazolam was then administered, followed by a continuous subcutaneous infusion of 1.5 mg of midazolam per hour. The Ramsay Sedation Scale was utilized to monitor depth of sedation, and the dosage of midazolam was titrated upward to maintain a deep level of sedation (a 4-mg bolus every 30-60 minutes, as needed, was utilized, with the continuous infusion increased by 0.5 mg/h after each bolus ...
Chau KY, Cooper JM, Schapira AH. Pramipexole reduces phosphorylation of α-synuclein at serine-129. J Mol Neurosci. 2013 Oct;51(2):573-80. PMID: 23681749.. Kitagawa K, Kitamura Y, Miyazaki T, et al. Effects of pramipexole on the duration of immobility during the forced swim test in normal and ACTH-treated rats. Naunyn Schmiedebergs Arch Pharmacol. 2009 Jul;380(1):59-66. PMID: 19274453.. Iravani MM, Sadeghian M, Leung CC, et al. Continuous subcutaneous infusion of pramipexole protects against lipopolysaccharide-induced dopaminergic cell death without affecting the inflammatory response. Exp Neurol. 2008 Aug;212(2):522-31. PMID: 18571649.. Zarate CA Jr, Payne JL, Singh J, et al. Pramipexole for bipolar II depression: a placebo-controlled proof of concept study. Biol Psychiatry. 2004 Jul 1;56(1):54-60. PMID: 15219473.. Ling ZD, Robie HC, Tong CW, et al. Both the antioxidant and D3 agonist actions of pramipexole mediate its neuroprotective actions in mesencephalic cultures. J Pharmacol Exp Ther. ...
Your doctor will determine the right dose of Remicade® for you and how often you should receive it. Make sure to discuss with your doctor when you will receive infusions and to come in for all your infusions and follow-up appointments.. A healthcare professional will monitor you during the Remicade® infusion and for a period of time afterward for side effects. Your doctor may do certain tests while you are taking Remicade® to monitor you for side effects and to see how well you respond to the treatment. If you begin to experience side effects from Remicade®, the infusion may need to be adjusted or stopped. Your healthcare professional may decide to treat your symptoms.. Remember: If you have any questions or changes in your health status at any point during the infusion process, be sure to discuss them with the healthcare professional overseeing your treatment. This summary is a general example of how infusion treatments may occur. Your infusion treatment may differ based on your healthcare ...
I was once advised to put Neo-Sporin ointment on the site hole and adhesive mark after taking it off to minimize redness and scarring. I tried it and it seemed to work for a while, but now that Im not so body conscious, I no longer do it. Antonio in Los Angeles Dx Type 1 1993 @ Age 27 Paradigm 512 -----Original Message----- From: email @ redacted [mailto:email @ redacted] On Behalf Of Adele Morgan Sent: Monday, November 17, 2003 11:41 AM To: email @ redacted Subject: [IP] infusion site scarring Just wanted to find out how long it takes for the infusion site holes on my stomach to fade and go away. Not that Im doing any swim suit modeling in the near future but Ive been on the pump since September of this year and I still can see every hole since I started. Im just wondering what my skin will look like after 5 - 10 years of this. Im blonde and blue eyed and probably more prone to scarring than most. Let me know what the veteran pumper have to say. Thanks Adele dx 1987 pumping since 9-9 -03 ...
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
The pharmacokinetics of continuous subcutaneous treprostinil are linear over the dose range of 2.5 to 125 ng/kg/min (corresponding to plasma concentrations of about 260 pg/mL to 18,250 pg/mL) and can be described by a two-compartment model. Dose proportionality at infusion rates greater than 125 ng/kg/min has not been studied.. Subcutaneous and intravenous administration of treprostinil demonstrated bioequivalence at steady state at a dose of 10 ng/kg/min.. Absorption Treprostinil is relatively rapidly and completely absorbed after subcutaneous infusion, with an absolute bioavailability approximating 100%. Steady-state concentrations occurred in approximately 10 hours. Concentrations in patients treated with an average dose of 9.3 ng/kg/min were approximately 2,000 ng/L.. Distribution The volume of distribution of the drug in the central compartment is approximately 14 L/70 kg ideal body weight. Treprostinil at in vitro concentrations well above what is clinically relevant was 91% bound to human ...
This new effort will also increase awareness among http://www.atlantic49.com.pl/boniva-injection-cost/ health best place to buy boniva online care settings, and equipment to administer the intravenous infusion treatments. This new effort will speed assistance to hard-hit communities to increase sequencing three-fold per week. Today, President Trump is taking to expand our capacity to get testing to help schools identify infected individuals without symptoms who may be contagious so that prompt action can be increased best place to buy boniva online quickly for underserved populations.. K-8 schools and underserved populations, including racial and ethnic minorities disproportionately largely due to poverty and uneven access to information, affordable testing, and medical and mental health care. A US federal agency, CDC helps make the healthy choice the easy choice by putting science and prevention into action. Assistance may include additional staffing, infusion center capacity in traditional and ...
Sénat M-V, Affres H, Letourneau A, Coustols-Valat M, Cazaubiel M, Legardeur H, Jacquier JF, Bourcigaux N, Simon E, Rod A, Héron I, Castera V, Sentilhes L, Bretelle F, Rolland C, Morin M, Deruelle P, De Carne C, Maillot F, Beucher G, Verspyck E, Desbriere R, Laboureau S, Mitanchez D, Bouyer J, for the Groupe de Recherche en Obstétrique et Gynécologie (GROG). Effect of glyburide vs subcutaneous insulin on perinatal complications among women with gestational diabetes. A randomized clinical trial. JAMA 2018;319:1 de junio. [Ref.ID 102766 ...
Late in 2013 I attended a presentation about the ACTs participation in this very significant national program. Current SCIg consumers (who made up the bulk of the audience), were enthusiastic about the introduction of SCIg. I attended as Health Care Consumers ACT (HCCA) Consumer Lead on the Standard 7 Committee (Blood and Blood Products ...
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2010 Original Price % Ret. P Price % Recomm 3/29/10 Q2 12/1/10 Ret. Abaxis ABAX 2/2/09 15 79 21.2 27.86 85 CardioV.Sys. CSII 11/5/10 7.15 8.65 21 Celera CRA 3/28/10 7 6.49 5.66 -19 Exact Sci EXAS 12/10/10 5.6 GenProbe GPRO 2/2/09 45 7 46.3 52.77 17 Illumina ILMN 2/2/09 29 35 43.1 61.79 113 […]. ...
Lauritzen T, Pramming S, Deckert T, Binder C (1983). "Pharmacokinetics Of Continuous Subcutaneous Insulin Infusion". ... This "infusion set" is patient-connected via a catheter to the abdomen region. The infusion set can remain in the place for ... to continuous subcutaneous insulin infusion (CSII) having basal doses of as little as 15 minutes and few bolus doses. The ... 2003). "Continuous Subcutaneous Glucose Monitoring Improved Metabolic Control in Pediatric Patients With Type 1 Diabetes: A ...
Infusion Set in a diabetic context, a tubing system to connect an insulin pump to the pump user, including a subcutaneous ... Continuous subcutaneous insulin infusion (CSII) See: Insulin pump. Contraindication A condition that makes a treatment not ... Subcutaneous injection Putting a fluid into the tissue under the skin with a needle and syringe. See also: Injection. Sucrose ... the latter use a subcutaneous catheter. Insulin reaction Too low a level of blood glucose (i.e., 'sugar') in the blood; also ...
Administered either by intravenous infusion or subcutaneous injection. These are naturally occurring proteins that regulate the ... Segal BM, Constantinescu CS, Raychaudhuri A, Kim L, Fidelus-Gort R, Kasper LH (September 2008). "Repeated subcutaneous ... Clinical trials have shown that subcutaneous ustekinumab was generally well tolerated. Most treatment-emergent adverse events ... Manufactured in the Netherlands, the subcutaneous human interleukin 12 and interleukin 23 antagonist are naturally occurring ...
"Lipoatrophic diabetes mellitus treated by continuous subcutaneous insulin infusion". Diabetes Metab. 24 (6): 544-6. PMID ...
It is administered by intermittent injections or continuous subcutaneous infusions. Since secondary effects such as confusion ... subcutaneous waking day apomorphine infusion and enteral dopa pumps may be useful. Late stage PD presents many challenges ... Intestinal infusions of levodopa (Duodopa) can result in striking improvements in fluctuations compared to oral levodopa when ...
An infusion takes about an hour. An alternative formulation for subcutaneous injection was approved in October 2013. ... ISBN 978-3-85200-196-8. "Genentech Gains FDA Approval for New Subcutaneous Formulation of Actemra for use in Adult Patients ... "FDA Approves Actemra (tocilizumab) Subcutaneous Injection for Giant Cell Arteritis". Drugs.com. "FDA approves tisagenlecleucel ... The drug is administered by monthly intravenous infusions. ...
Intravenous or subcutaneous infusion of anti-inflammatory (TNF inhibitors; anti-TNF-alpha) drugs such as infliximab, and ... Schawartz's principles of surgery, 8th edition, self assessment an board review, chapter 15, the skin and subcutaneous tissue, ...
"EU approves second indication for subcutaneous form of Roche's rituximab". Archived from the original on 7 June 2016. Retrieved ... Serious adverse events, which can cause death and disability, include: Severe infusion reaction. Cardiac arrest Cytokine ... "MabThera 100 mg Concentrate for Solution for Infusion - Summary of Product Characteristics (SmPC)". (emc). 13 March 2021. ... "MabThera 1400 mg Solution for Subcutaneous Injection - Summary of Product Characteristics (SmPC)". (emc). 13 March 2021. ...
Diazoxide is given by mouth, octreotide by injection or continuous subcutaneous pump infusion. When congenital hyperinsulinism ... Even after pancreatectomy, continuous glucose may be needed in the form of gastric infusion of formula or dextrose. High dose ...
A common example is continuous intravenous infusion. First-order absorption: rate of absorption is proportional to the amount ... Representative examples include typical cases of oral administration, subcutaneous injection, and intramuscular injection. ...
Hussain, MA; Green, N; Flynn, DM; Hussein, S; Hoffbrand, AV (Dec 1976). "Subcutaneous infusion and intramuscular injection of ... In 1976, Richard Propper and David Nathan suggested the use of subcutaneous desferrioxamine to prevent death from iron overload ...
"Intradermal insulin infusion achieves faster insulin action than subcutaneous infusion for 3-day wear". Drug Delivery and ... Subcutaneous injection Intramuscular injection Intravenous injection Rini CJ, McVey E, Sutter D, Keith S, Kurth HJ, Nosek L, ... This route is relatively rare compared to injections into the subcutaneous tissue or muscle. Due to the more complex use, ID ... applied in novel closed loop insuline infusion systems. Additionally, the body's reaction to substances is more easily visible ...
"HyQvia 100 mg/ml solution for infusion for subcutaneous use - Summary of Product Characteristics (SmPC)". (emc). 15 January ... It is a dual vial unit with one vial of immune globulin infusion 10% (human) and one vial of recombinant human hyaluronidase. ... "Hyalase 1500 I.U. Powder for Solution for Injection/Infusion or Hyaluronidase 1500 I.U. Powder for Solution for Injection/ ... It also increases the absorption rate of parenteral fluids given by hypodermoclysis, and is an adjunct in subcutaneous ...
... may be administered as a continuous subcutaneous infusion or continuous intravenous infusion via a small infusion ... It may be administered as a continuous subcutaneous infusion or continuous intravenous infusion; however, because of the risks ... Treprostinil can be given subcutaneously by continuous infusion using an infusion set connected to an infusion pump, but also ... Abrupt cessation of infusion should be avoided. Restarting a Remodulin infusion within a few hours after an interruption can be ...
... a disposable infusion set, including a cannula for subcutaneous insertion (under the skin) and a tubing system to connect the ... "Treatment of type I diabetic with subcutaneous insulin resistance by a totally implantable insulin infusion device ("Infusaid ... "Reduction of glycosylated hemoglobin following 6 months of continuous subcutaneous insulin infusion in an Indian population ... An extended bolus is a slow infusion of insulin spread out over time. By pumping with a "square wave" shape, the bolus avoids a ...
In 1966, investigators noted that the intravenous infusion of PC-containing solutions could remove fat emboli. Later, a drug ... Duncan, D.I.; Hasengschwandtner, F (2005). "Lipodissolve for Subcutaneous Fat Reduction and Skin Retraction". Aesthetic Surg J ... The mixture is injected directly into the subcutaneous fat through multiple microinjections administered over multiple ... "Lipomas treated with subcutaneous deoxycholate injections". Journal of the American Academy of Dermatology. 53 (6): 973-8. doi: ...
... also showed improvement in primary hypersomnia symptoms after treatment with a continuous subcutaneous flumazenil infusion. The ... Kelty E, Martyn V, O'Neil G, Hulse G (July 2014). "Use of subcutaneous flumazenil preparations for the treatment of idiopathic ...
... is available in a portable infusion pump that provides pulsatile subcutaneous administration of the drug. The usual ... It is also available in solution form for intravenous or subcutaneous injection and as a nasal spray. Gonadorelin is an agonist ... Micropump infusion of gonadorelin in the treatment of hypogonadotropic hypogonadism in patients with pituitary stalk ...
"Slow subcutaneous infusion of flumazenil for the treatment of long-term, high-dose benzodiazepine users: a review of 214 cases ... Low-dose, slow subcutaneous flumazenil administration is a safe procedure for patients withdrawing from long-term, high-dose ... "Low risk of seizures with slow flumazenil infusion and routine anticonvulsant prophylaxis for high-dose benzodiazepine ... Description of 29 patients treated with flumazenil infusion and stabilised with clonazepam". Psychiatry Research. 198 (3): 457- ...
Flumazenil delivered via slow subcutaneous infusion represents a safe procedure for those withdrawing from long-term, high dose ... "Slow subcutaneous infusion of flumazenil for the treatment of long-term, high-dose benzodiazepine users: a review of 214 cases ... "Low risk of seizures with slow flumazenil infusion and routine anticonvulsant prophylaxis for high-dose benzodiazepine ...
The etanercept group received subcutaneous injections of the drug twice weekly for 12 weeks while the ustekinumab group ... Clinical trials have shown that subcutaneous ustekinumab was generally well tolerated. Most treatment-emergent adverse events ... "Repeated subcutaneous injections of IL12/23 p40 neutralising antibody, ustekinumab, in patients with relapsing-remitting ... subcutaneous injection, Infusion. ATC code. *L04AC05 (WHO) Legal status. Legal status. *UK: POM (Prescription only) ...
Since it has a half-life of 3 to 5 minutes, the infusion has to be continuous, and interruption can be fatal. Other prostanoids ... Treprostinil can be given intravenously or subcutaneously, but the subcutaneous form can be very painful. An increased risk of ... Epoprostenol (synthetic prostacyclin) is given via continuous infusion that requires a semi-permanent central venous catheter. ... Comparative efficiency of infecting laboratory animals via intravenous and subcutaneous administration of Schistosoma mansoni ...
Intravesical infusion is into the urinary bladder. Intravitreal, through the eye. Subcutaneous (under the skin). This generally ... Intraosseous infusion (into the bone marrow) is, in effect, an indirect intravenous access because the bone marrow drains ... Intraperitoneal, (infusion or injection into the peritoneum) e.g. peritoneal dialysis. Intrathecal (into the spinal canal) is ... Skin popping is a slang term that includes subcutaneous injection, and is usually used in association with recreational drugs. ...
Subcutaneous immunoglobulin is under study as a less invasive, more-convenient alternative to IV delivery. Roth, G; Rohr J; ... IVIg is the primary treatment, with about 80% of patients responding, usually requiring regular infusions at intervals of 1 ... Harbo T, Andersen H, Hess A, Hansen K, Sindrup SH, Jakobsen J (2009). "Subcutaneous versus intravenous immunoglobulin in ...
... daily subcutaneous injection for treatment of venous thromboembolism and in unstable angina instead of intravenous infusion of ... Less frequent subcutaneous dosing than for heparin for postoperative prophylaxis of venous thromboembolism. Once or twice ...
... infertility in hypopituitarism may be treated with subcutaneous infusions of FSH, human chorionic gonadotropin-which mimics the ...
An infusion of lidocaine increased blood flow in subcutaneous tissue and normalised the vasoconstrictor response when the limbs ... On the other hand, the pain relief effect was the greatest at about 20 minutes after the end of the infusion. Based on this, ... The EEG showed slow waves appearing 7 minutes after the start of the infusion and disappearing within 20 minutes after the end ... Subcutaneous Adipose Tissue Diseases: Dercum Disease, Lipedema, Familial Multiple Lipomatosis and Madelung Disease. In: Purnell ...
Stibe CM, Lees AJ, Kempster PA, Stern GM (February 1988). "Subcutaneous apomorphine in parkinsonian on-off oscillations". ... either as intermittent injections or continuous infusion) and sublingual. Other non-invasive administration routes were ... Chaudhuri KR, Clough C (February 1998). "Subcutaneous apomorphine in Parkinson's disease". BMJ. 316 (7132): 641. doi:10.1136/ ... Alternative administration routes Two routes of administration are currently clinically utilized: subcutaneous ( ...
Naloxone comes with a variety of delivery systems, including nasal spray, intravenous infusion, as well as subcutaneous and ...
... , which can also be called interstitial infusion or subcutaneous infusion, is the subcutaneous administration of ... Hypodermoclysis can be used where a slow rate of fluid uptake is required compared to intravenous infusion. Typically, it is ... The chief advantages of hypodermoclysis over intravenous infusion is that it is cheap and can be administered by non-medical ... Menahem Sasson, Pesach Shvartzman, "Hypodermoclysis: an alternative infusion technique", American Family Physician, vol. 64, no ...
1957). "Intravenous infusion of bone marrow in patients receiving radiation and chemotherapy". New England Journal of Medicine ... The peripheral stem cell yield is boosted with daily subcutaneous injections of Granulocyte-colony stimulating factor, serving ... Mucositis is treated with pain medications plus intravenous infusions to prevent dehydration and malnutrition. ... the purpose of which is to help eradicate the patient's disease prior to the infusion of HSC and to suppress immune reactions. ...
"EU approves second indication for subcutaneous form of Roche's rituximab". Archived from the original on 2016-06-07. Retrieved ... Severe infusion reaction.. *Cardiac arrest. *Cytokine release syndrome. *Tumor lysis syndrome, causing acute renal failure ... in 2016 it gained EU approval in a formulation for subcutaneous injection for CLL.[48] ...
infusion. (into tissue/blood). Skin. *Intradermal. *Subcutaneous. *Transdermal implant. Organs. *Intracavernous. *Intravitreal ...
... s - less commonly[1] called tisanes (UK and US /tɪˈzæn/, US also /tɪˈzɑːn/)[2] - are beverages made from the infusion ... Coca tea, infusion made from coca leaves. Contains trace amounts of cocaine and similar alkaloids.[15] In some countries where ... While varieties of herbal teas are defined as any plant material for infusion, below is a list of common herbs: *Anise tea, ... Rooibos (Red Bush), reddish plant used to make an infusion and grown in South Africa. In the US it is sometimes called red tea ...
... subcutaneous (SQ) - Substance Abuse and Mental Health Services Administration (SAMHSA) - subunit HIV vaccine - sulfa drug - ... infusion - inoculation - institutional review board (IRB) - integrase - integrase inhibitors - interaction - interferon - ...
Sperm production can be achieved through either the use of GnRH administered via a micro infusion pump or through the use of ... For males with KS/CHH the types of testosterone delivery include daily patches, daily gel use, daily capsules, sub cutaneous or ...
Types of infusions[edit]. Continuous infusion[edit]. A continuous infusion is primarily used to correct fluid and electrolyte ... Infusion pumps[edit]. An infusion pump allows precise control over the flow rate and total amount delivered. The volume to be ... or infusions (typically using only the pressure supplied by gravity). Intravenous infusions are commonly referred to as drips. ... "IV Infusion: Explanatory Note". U.S. Anti-Doping Agency (USADA). 5 January 2018. Retrieved 24 July 2018.. ...
infusion. (into tissue/blood). Skin. *Intradermal. *Subcutaneous. *Transdermal implant. Organs. *Intracavernous. *Intravitreal ...
The concomitant infusion of albumin can avert the circulatory dysfunction that occurs after large-volume paracentesis and may ... observational study of individuals with HRS treated with subcutaneous octreotide and oral midodrine showed that there was ... These include the use of intravenous albumin infusion, medications (for which the best evidence is for analogues of vasopressin ...
... subcutaneous waking day apomorphine infusion and enteral dopa pumps can be of use.[76] The third stage presents many ... It is administered by intermittent injections or continuous subcutaneous infusions.[74] Since secondary effects such as ... Intestinal infusions of levodopa (Duodopa) can result in striking improvements in fluctuations compared to oral levodopa when ...
It is claimed by its manufacturer that it can deliver intramuscular injections and subcutaneous injections up to 1 milliliter. ... "Virus Transmission by Subcutaneous Jet Injection". J Med Microbiol. 20 (3): 393-7. doi:10.1099/00222615-20-3-393. PMID 4068027 ...
However, it is now known that rapid infusion of NS can cause metabolic acidosis.[11] ... Hypertonic saline may be used in perioperative fluid management protocols to reduce excessive intravenous fluid infusions and ... Prough, DS; Bidani, A (1999). "Hyperchloremic metabolic acidosis is a predictable consequence of intraoperative infusion of 0.9 ... or via any saline infusion , 40 mmol/L (Na+ having a valence of 1, 40 mmol/L = 40 mEq/L) greatly increases risk of central ...
Isolated limb perfusion (often used in melanoma),[61] or isolated infusion of chemotherapy into the liver[62] or the lung have ... Clinical electrochemotherapy has been successfully used for treatment of cutaneous and subcutaneous tumors irrespective of ... These include the winged infusion device, peripheral venous catheter, midline catheter, peripherally inserted central catheter ... highly effective and safe treatment of cutaneous and subcutaneous metastases". Eur J Cancer Suppl. 4 (11): 3-13. doi:10.1016/j. ...
Intramuscular injection can be complicated in that the depth of subcutaneous fat varies and may result in subcutaneous ... Epinephrine infusions may also be used for symptomatic bradycardia.[18] Anaphylaxis[edit]. Epinephrine is the drug of choice ... When given by the subcutaneous or intramuscular routes for asthma, an appropriate dose is 0.3 to 0.5 mg.[26][27] ... Intramuscular injection does give a faster and higher pharmacokinetic profile when compared to subcutaneous injection.[24] ...
Frequent infusions of beta-lactam antibiotics without exceeding total daily dose would help to keep the antibiotics level above ... Shear MJ (1944). "Chemical treatment of tumors, IX: Reactions of mice with primary subcutaneous tumors to injection of a ... September 2016). "Continuous versus intermittent β-Lactam infusion in severe sepsis. A meta-analysis of individual patient data ...
Subcutaneous emphysema indicates backpressure created by undrained air, often caused by a clogged chest tube or insufficient ... Minor complications include a subcutaneous hematoma or seroma, anxiety, shortness of breath (dyspnea), and cough (after ... negative pressure.[citation needed] If a patient has subcutaneous emphysema, it is likely their chest tube is not draining and ... Intraosseous infusion (IO). *Intravenous therapy (IV). *Tracheal intubation. *Laryngeal tube. *Combitube. *Nasopharyngeal ...
Intraosseous infusion (IO). *Intravenous therapy (IV). *Tracheal intubation. *Laryngeal tube. *Combitube. *Nasopharyngeal ...
infusion. (into tissue/blood). Skin. *Intradermal. *Subcutaneous *Injector pen. *Transdermal implant. Organs. *Intracavernous ...
... stem cells are collected from donor's blood through a process known as apheresis after a certain period of daily subcutaneous ... regimen of reduced-intensity chemotherapy plus G-CSF mobilized HLA-mismatched allogeneic peripheral blood stem cell infusion, ...
The intramuscular route is preferred over subcutaneous administration because the latter may have delayed absorption.[4][5] ...
Weinberg AC, Lieskovsky G, McGehee WG, Skinner DG (August 1983). "Warfarin necrosis of the skin and subcutaneous tissue of the ... the relative efficacy of infusions of fresh frozen plasma and clotting factor concentrate on correction of the coagulopathy". ...
Andrew Dickman; Jennifer Schneider (22 September 2016). The Syringe Driver: Continuous Subcutaneous Infusions in Palliative ...
infusion. (into tissue/blood). Skin. *Intradermal. *Subcutaneous. *Transdermal implant. Organs. *Intracavernous. *Intravitreal ...
Large-bore venous access with isotonic fluid infusion is recommended to maintain blood pressure and pulse.[47] ... interstitial and subcutaneous emphysemas, not usually all at the same time. ...
Types of infusions[edit]. Continuous infusion[edit]. A continuous infusion is primarily used to correct fluid and electrolyte ... Infusion pumps[edit]. An infusion pump allows precise control over the flow rate and total amount delivered. The volume to be ... The Infusion Nurses Society offers comprehensive evidence-based educational resources for its members. The Infusion Nurses ... or infusions (typically using only the pressure supplied by gravity). Intravenous infusions are commonly referred to as drips. ...
Terminal elimination half-life: Approximately 10 hours after both intravenous infusion and subcutaneous bolus injection[3]. ... The subcutaneous formulation was developed in Switzerland in the early 1990s and it was commercialized by Lipomed GmbH in the ... hairy cell leukemia and for B-cell chronic lymphocytic leukemia and is administered by intravenous or subcutaneous infusion.[5] ... Beutler tested it as intravenous infusion and found it was especially useful to treat hairy cell leukemia (HCL). No ...
Ig replacement therapy are infusions that can be either subcutaneous or intravenously administrated, resulting in higher Ig ... The treatment of primary immunodeficiencies depends on the nature of the defect, and may involve antibody infusions, long-term ...
Continuous local anaesthetic wound infusion for postoperative pain after midline laparotomy for colorectal resection in adults ... Subcutaneous closure versus no subcutaneous closure after non-caesarean surgical procedures PMID 24446384 https://doi.org/ ... Sumatriptan (subcutaneous route of administration) for acute migraine attacks in adults PMID 22336869 https://doi.org/10.1002/ ...
Continuous subcutaneous insulin infusion.. American Diabetes Association.. PMID:. 14693943. DOI:. 10.2337/diacare.27.2007.s110 ...
Thank you for your interest in spreading the word about Diabetes Care.. NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.. ...
Comparison of Continuous Subcutaneous Insulin Infusion and Multiple Daily Injection Regimens in Children With Type 1 Diabetes: ...
Continuous subcutaneous insulin infusion (CSII) is one of the ways to control blood glucose for prolonged periods. This study ... Patient self-management of continuous subcutaneous insulin infusion Diabetes Care. Sep-Oct 1982;5(5):485-91. doi: 10.2337/ ... Continuous subcutaneous insulin infusion (CSII) is one of the ways to control blood glucose for prolonged periods. This study ... Basal infusion of insulin, representing 50% of the total pre-CSII dose, was supplemented by boluses of insulin based on ...
Continuous subcutaneous insulin infusion: an approach to achieving normoglycaemia. Br Med J 1978; 1 :204 ... Continuous subcutaneous insulin infusion: an approach to achieving normoglycaemia.. Br Med J 1978; 1 doi: https://doi.org/ ...
... Francesco Rotella,1 Caterina Lamanna,1 Ilaria ... Continuous subcutaneous insulin infusion (CSII) is used as an option in patients with diabetes failing to multiple daily ...
Assessment of therapy with continuous subcutaneous insulin infusion in an academic diabetes clinic.. Rudolph JW1, Hirsch IB. ... To assess the results of continuous subcutaneous insulin infusion (CSII) therapy in patients with type 1 diabetes mellitus, ...
IV infusion: IV infusion. Antoinette R. Tan, MD, MHSc, Chief of Breast Medical Oncology, Co-Director of the Phase I Program, ... Subcutaneous Treatment vs. IV Infusion for HER2-Positive Breast Cancer. Holt, Chuck ... reduced infusion chair time and improved capacity in infusion centers;. *shortened drug administration time and more flexible ... In previous studies of other subcutaneous formulations, subcutaneous delivery of trastuzumab has been shown to be strongly ...
Lidocaine Subcutaneous Infusion for Control of Treprostinil Related Site Pain. Official Title ICMJE Lidocaine Subcutaneous ... Lidocaine Subcutaneous Infusion for Control of Treprostinil Related Site Pain. The safety and scientific validity of this study ... Treprostinil subcutaneous (under the skin) infusion is a very good medication for treating pulmonary arterial hypertension but ... The investigators plan to treat patients receiving treprostinil with a subcutaneous infusion of lidocaine (a local anesthestic ...
AG, A. (2008, June 5). "EMEA Application For Nenad(R) (lisuride) Transdermal Patch And Subcutaneous Infusion For Parkinsons ... " and subcutaneous (sc) lisuride infusion for advanced Parkinsons Disease) Lisuride, the active principle of Nenad(R), is a ... Lisuride sc (Nenad(R) Powder for solution for sc infusion) was developed for the treatment of patients in an advanced stage of ... potent dopamine agonist which in its parenteral forms (transdermal patch and sc infusion) has been developed to provide ...
Lidocaine Subcutaneous Infusion for Control of Treprostinil Related Site Pain. The safety and scientific validity of this study ... Treprostinil subcutaneous (under the skin) infusion is a very good medication for treating pulmonary arterial hypertension but ... The investigators plan to treat patients receiving treprostinil with a subcutaneous infusion of lidocaine (a local anesthestic ... infusion site pain may be very severe in some patients. ... Lidocaine Subcutaneous Infusion for Control of Treprostinil ...
... support for patients choosing SCIG home infusion therapy throughout BC. Patients must have a doctor referral. Physicians can ... This teaching clinic provides consultations, education, support for patients choosing SCIG home infusion therapy throughout BC ...
If you are a society or association member and require assistance with obtaining online access instructions please contact our Journal Customer Services team ...
Experimental: ultradian subcutaneous hydrocortisone ultradian subcutaneous hydrocortisone infusion, Solu-Cortef ® 50mg/ml ... Experimental: continuous subcutaneous hydrocortisone continuous subcutaneous hydrocortisone infusion (CSHI), Solu-Cortef ® 50mg ... tablet treatment versus continuous subcutaneous hydrocortisone infusion versus ultradian subcutaneous hydrocortisone infusion ... Ultradian Subcutaneous Hydrocortisone Infusion in Addison Disease and Congenital Adrenal Hyperplasia. The safety and scientific ...
Experimental: Continuous Subcutaneous Insulin Infusion CSII. Drug: Transient Continuous Subcutaneous Insulin Infusion Patients ... Continuous Subcutaneous Insulin Infusion strAtegy Versus Multiple Daily Insulin Injections strAtegy (CAMACS). The safety and ... Drug: Transient Continuous Subcutaneous Insulin Infusion Drug: Transient Multiple Daily Insulin Injections Phase 4 ... Continuous subcutaneous insulin infusion (CSII) and multiple daily insulin injections (MDI) in patients who are not well ...
continuous subcutaneous insulin infusion • DCCT = Diabetes Control and Complications Trial • MDI = multiple daily injections • ... 1980) Continuous subcutaneous insulin infusion in the treatment of diabetes mellitus. Diabetes Care. 3:290-300. ... 1978) Continuous subcutaneous insulin infusion: an approach to achieving normoglycemia. Br J Med 1:204-207. ... Continuous Subcutaneous Insulin Infusion Therapy for Children and Adolescents: An Option for Routine Diabetes Care. Aristides K ...
... which has led to a dramatic increase in continuous subcutaneous insulin infusion (CSII) or insulin pump use. In this article, ... Continuous subcutaneous insulin infusion: a comprehensive review of insulin pump therapy Arch Intern Med. 2001 Oct 22;161(19): ... which has led to a dramatic increase in continuous subcutaneous insulin infusion (CSII) or insulin pump use. In this article, ...
... glycemic control and frequency of diabetic complications in Italian people with diabetes treated with continuous subcutaneous ... Metabolic control and complications in Italian people with diabetes treated with continuous subcutaneous insulin infusion. *. ... A 57-year-old woman with uncontrolled diabetes presented with palatal necrosis and hardening of the subcutaneous tissue at the ... and frequency of diabetic complications in Italian people with diabetes treated with continuous subcutaneous insulin infusion ( ...
Effects of Liraglutide Combined with Short-Term Continuous Subcutaneous Insulin Infusion on Glycemic Control and Beta Cell ... this paper is to investigate the effects of liraglutide in combination with short-term continuous subcutaneous insulin infusion ...
Relative Bioavailability Study of Subcutaneous Injection Versus Intravenous Infusion of Pembrolizumab (MK-3475) in Participants ... Relative Bioavailability Study of Subcutaneous Injection Versus Intravenous Infusion of Pembrolizumab (MK-3475) in Participants ... And, finally, the efficacy of pembrolizumab intravenous (IV) infusion administration will be assessed. ... following single subcutaneous (SC) injection of pembrolizumab Dose A versus pembrolizumab Dose C in adults with advanced ...
Continuous subcutaneous insulin infusion versus multiple daily injections of insulin for pregnant women with diabetes. What is ... Continuous subcutaneous insulin infusion versus multiple daily injections of insulin for pregnant women with diabetes. Cochrane ... An alternative method of insulin administration is the continuous subcutaneous insulin infusion pump (CSII). ...
Efficacy and Safety of Long Term Treatment of Unresponsive Hypoparathyroidism Using Multipulse Subcutaneous Infusion of ... Subcutaneous (s. c.) recombinant human PTH 1-34 (rhPTH-teriparatide) plus oral calcitriol, calcium, and magnesium, were ... The only significant side effect observed during these years was the development of subcutaneous nodules with occasional ... Multipulse s. c. pump driven infusion of teriparatide achieved complete normalization of serum calcium, phosphate, magnesium, ...
Medical Therapy Module 8 course will provide a comprehensive overview to the introduction and complications of subcutaneous ... apomorphine injections and continuous infusions. This module was reviewed for content and accuracy in June of 2020. ... Introduction and Complications of Subcutaneous Apomorphine Injections and Continuous Infusions. Length:60 Minutes. CME Credits: ... Introduction and Complications of Subcutaneous Apomorphine Injections and Continuous Infusions ...
For Needle Site Changes (for subcutaneous infusion only) Using the Medtronic Quick-Set® The Quick-set® is a small needle used ... For Needle Site Changes (for subcutaneous infusion only). HFFY#7779. Category: Medication Instructions ... infusion pump with bag of lidocaine  new pump tubing  Quick-set®  needle discard box 3. Connect the Quick-set® to the pump ... in the continuous subcutaneous administration of medicine. This means that the needle will go just below the surface of the ...
... to quantify the impact of treatment of hypoglycaemia-prone type 1 diabetic subjects by continuous subcutaneous insulin infusion ... Effectiveness of continuous subcutaneous insulin infusion in hypoglycaemia-prone type 1 diabetes ... to quantify the impact of treatment of hypoglycaemia-prone type 1 diabetic subjects by continuous subcutaneous insulin infusion ...
Subcutaneous,Infusion,of,Cenderitide,in,Chronic,Heart,Failure,Patients,medicine,advanced medical technology,medical laboratory ... safety and tolerability of subcutaneous bolus and subcutaneous infusion of cenderitide in patients with chronic heart failure. ... Nile Therapeutics Completes Dosing of Clinical Trial Evaluating the Subcutaneous Infusion of Cenderitide in Chronic Heart ... cenderitide when administered to chronic heart failure patients as a subcutaneous bolus injection or as a subcutaneous infusion ...
Open Approach is a medical classification as listed by CMS under Subcutaneous Tissue and Fascia range. ... ICD-10-PCS code 0JH60VZ for Insertion of Infusion Pump into Chest Subcutaneous Tissue and Fascia, ... ICD-10-PCS code 0JH60VZ for Insertion of Infusion Pump into Chest Subcutaneous Tissue and Fascia, Open Approach is a medical ... Insertion of Infusion Pump into Chest Subcutaneous Tissue and Fascia, Open Approach 0JH60VZ. ...
On the difficulties presented by a group of diabetic patients subjected to continuous insulin infusion through subcutaneous ... On the difficulties presented by a group of diabetic patients subjected to continuous insulin infusion through subcutaneous ...
Percutaneous Approach is a medical classification as listed by CMS under Subcutaneous Tissue and Fascia range. ... ICD-10-PCS code 0JHP3VZ for Insertion of Infusion Pump into Left Lower Leg Subcutaneous Tissue and Fascia, ... Insertion of Infusion Pump into Left Lower Leg Subcutaneous Tissue and Fascia, Percutaneous Approach 0JHP3VZ. ... Insertion of Infusion Pump into Left Lower Leg Subcutaneous Tissue and Fascia, Percutaneous Approach ...
In contrast, the expression of UCP-2 was not affected by lipid infusion in skeletal muscle or in subcutaneous adipose tissue. ... 9+/-2 amol/microg total RNA, respectively). We conclude that increased plasma NEFA levels by lipid infusion for 5 h induces the ... 17+/-3 amol/microg total RNA, P = 0.027) mRNA levels increased in skeletal muscle during triglyceride infusion. UCP-3L mRNA ... During triglyceride infusion, physiological hyperinsulinemia appears to prevent the induction of UCP-3 mRNA levels. ...
  • Continuous subcutaneous insulin infusion (CSII) is one of the ways to control blood glucose for prolonged periods. (nih.gov)
  • Basal infusion of insulin, representing 50% of the total pre-CSII dose, was supplemented by boluses of insulin based on carbohydrate intake for each meal. (nih.gov)
  • Continuous subcutaneous insulin infusion (CSII) is used as an option in patients with diabetes failing to multiple daily injections (MDI). (hindawi.com)
  • To assess the results of continuous subcutaneous insulin infusion (CSII) therapy in patients with type 1 diabetes mellitus, especially relative to glycemic control and rate of discontinuation of insulin pump therapy. (nih.gov)
  • The current study will compare the different efficacy of two transient intensive insulin treatment strategies: Continuous subcutaneous insulin infusion (CSII) and multiple daily insulin injections (MDI) in patients who are not well controlled with oral hypoglycaemic agents. (clinicaltrials.gov)
  • The purpose of this study was to determine the feasibility of continuous subcutaneous insulin infusion (CSII) (insulin pump) therapy in routine pediatric diabetes care by comparing the HbA 1c , body mass index (BMI), and hypoglycemic episodes before and after initiation of CSII therapy. (aappublications.org)
  • The concept of continuous subcutaneous insulin infusion (CSII) is not novel. (aappublications.org)
  • A tremendous amount of data suggest that near-normal glycemic control prevents or delays complications of diabetes, which has led to a dramatic increase in continuous subcutaneous insulin infusion (CSII) or insulin pump use. (nih.gov)
  • The objective of this cross-sectional study was to evaluate degree of glycemic control and frequency of diabetic complications in Italian people with diabetes treated with continuous subcutaneous insulin infusion (CSII). (medworm.com)
  • The objective of this paper is to investigate the effects of liraglutide in combination with short-term continuous subcutaneous insulin infusion (CSII) therapy on glycemic control and beta cell function in patients with newly diagnosed type 2 diabetes mellitus (T2DM). (hindawi.com)
  • An alternative method of insulin administration is the continuous subcutaneous insulin infusion pump (CSII). (cochrane.org)
  • The aim of this study was to quantify the impact of treatment of hypoglycaemia-prone type 1 diabetic subjects by continuous subcutaneous insulin infusion (CSII). (ovid.com)
  • Continuous subcutaneous insulin infusion (CSII) devices have gained wide acceptance in diabetes care. (grandviewresearch.com)
  • To analyze the clinical impact of the Flash glucose monitoring system in patients with type 1 diabetes mellitus (T1DM) treated with continuous subcutaneous insulin infusion (CSII). (elsevier.es)
  • Intensive therapy for type 1 diabetes mellitus (DM) is usually provided by either multiple daily injections of insulin (MDI) or by insulin pump (continuous subcutaneous insulin infusion CSII). (semanticscholar.org)
  • To determine the safety and efficacy of U-500 regular insulin delivered by continuous subcutaneous insulin infusion (CSII) as treatment for patients with type 2 diabetes and severe insulin resistance (mean 24-hour insulin requirement, 1.46 U/kg daily) who had failure of previous insulin therapy with either multiple daily injection (MDI) regimens or CSII using U-100 insulin analogues. (ovid.com)
  • OBJECTIVE: The purpose of this study is to determine whether parental knowledge of the continuous subcutaneous insulin infusion (CSII) device affects glycemic control as measured by hemoglobin A1c (A1C) level. (umassmed.edu)
  • This can be achieved by a continuous subcutaneous insulin infusion (CSII) or by multiple daily injections (MDI) using a combination of long-acting basal insulin (glargine or detemir) and a short-acting insulin (lispro, aspart, or glulisine) to control postprandial hyperglycemia. (diabetestalk.net)
  • Present day treatment has evolved from conventional 2 injections per day, to multiple daily injections (MDI) 4-5 per day, to continuous subcutaneous insulin infusion (CSII) having basal doses of as little as 15 minutes and few bolus doses. (wikipedia.org)
  • The objective of CSII is to reduce the long-term variability of blood glucose by increasing the frequency of infusion. (wikipedia.org)
  • Subcutaneous (s. c.) recombinant human PTH 1-34 (rhPTH-teriparatide) plus oral calcitriol, calcium, and magnesium, were partially effective, but effectiveness of 20 μg teriparatide lasted less than 4 h and stable calcemia was not possible even with 4-6 injections/day. (biomedsearch.com)
  • The MDS-Device Aided Medical Therapy Module 8 course will provide a comprehensive overview to the introduction and complications of subcutaneous apomorphine injections and continuous infusions. (movementdisorders.org)
  • The primary purpose of this program is to provide information on the introduction and complications of subcutaneous apomorphine injections and continuous infusions. (movementdisorders.org)
  • In Part A of the trial, 12 patients received two subcutaneous bolus injections of cenderitide. (bio-medicine.org)
  • Intensive glucose control (3 or more daily insulin injections or continuous subcutaneous insulin infusion) reduced the mean risk of retinopathy progression by 54% in type 1 diabetes patients with minimal-to-moderate retinopathy. (silverbook.org)
  • Continuous subcutaneous insulin infusion versus multiple daily injections in adolescents with type I diabetes mellitus: a randomized open crossover trial. (semanticscholar.org)
  • Continuous subcutaneous insulin infusion versus multiple daily injections in children and young people at diagnosis of type 1 diabetes: the SCIPI RCT. (semanticscholar.org)
  • Intensive glucose control (3 or more daily insulin injections or continuous subcutaneous insulin infusion) reduced the mean risk of retinopathy by 76% in type 1 diabetes patients who had not developed retinopathy. (silverbook.org)
  • What's the difference between infusion therapy and subcutaneous injections? (healthguru.com)
  • Biologic injections or biologic infusion therapy-- the choice is hard to make. (healthguru.com)
  • Watch this to learn how tho choose between injections or infusions for RA. (healthguru.com)
  • Abstract The level of glycaemic control necessary to achieve optimal short-term and long-term outcomes in subjects with type 1 diabetes mellitus (T1DM) typically requires intensified insulin therapy using multiple daily injections or continuous subcutaneous insulin infusion. (diabetestalk.net)
  • The advantages of continuous subcutaneous insulin infusion over multiple daily injections in adult and paediatric populations with T1DM include superior glycaemic control, lower insulin requirements and better health-related quality of life/patient satisfaction. (diabetestalk.net)
  • Although more expensive than multiple daily injections, continuous subcutaneous insulin infusion is cost-effective in selected patient groups. (diabetestalk.net)
  • The etanercept group received subcutaneous injections of the drug twice weekly for 12 weeks while the ustekinumab group received two injections, one month apart, of either 90 or 45 milligrams. (wikipedia.org)
  • Over the course of the 12-week study, participants were randomized, some receiving three to eight milligrams per hour of apomorphine subcutaneous injections, while others received a placebo saline infusion. (parkinson.org)
  • Multipulse s. c. pump driven infusion of teriparatide achieved complete normalization of serum calcium, phosphate, magnesium, calciuria, and magnesuria with relatively low teriparatide doses (25-35 μg/day) after the first day of treatment. (biomedsearch.com)
  • infusion pump with bag of lidocaine  new pump tubing  Quick-set®  needle discard box 3. (uwhealth.org)
  • The trial was designed to understand the doses required to achieve pre-determined plasma levels of cenderitide when delivered through a subcutaneous infusion pump. (bio-medicine.org)
  • In Part B of the trial, 34 patients received a 24-hour continuous infusion of either of two fixed doses of cenderitide or placebo, delivered through Medtronic's subcutaneous pump technology. (bio-medicine.org)
  • In Part C, 12 patients received a 24-hour continuous infusion of either a weight-based dose of cenderitide, or placebo, delivered through Medtronic's subcutaneous pump technology. (bio-medicine.org)
  • ICD-10-PCS code 0JH60VZ for Insertion of Infusion Pump into Chest Subcutaneous Tissue and Fascia, Open Approach is a medical classification as listed by CMS under Subcutaneous Tissue and Fascia range. (aapc.com)
  • programmable pump subcutaneously delivers rapid-acting insulin through infusion set devices. (grandviewresearch.com)
  • The increasing penetration of the smart insulin pump has extended the market for continuous subcutaneous insulin infusion across the region. (grandviewresearch.com)
  • Major players in the market for continuous subcutaneous insulin infusion are now investing heavily in the development of artificial pancreas as compared to other pump choices. (grandviewresearch.com)
  • The patch pump segment is growing at a rapid pace in the market for continuous subcutaneous insulin infusion owing to increasing adoption and rising number of product launches. (grandviewresearch.com)
  • Should we consider subcutaneous apomorphine infusions for Parkinson's disease patients who do not want deep brain stimulation or a dopamine pump? (parkinson.org)
  • The initial programming of the external insulin infusion pump should be based on the total daily insulin dose of the previous regimen. (rxlist.com)
  • APIDRA-specific information should be followed for in-use time, frequency of changing infusion sets, or other details specific to APIDRA usage, because APIDRA-specific information may differ from general pump manual instructions. (rxlist.com)
  • Cortisol pump: Continuous Subcutaneous Hydrocortisone Infusion - a patient experience. (aiunited.org)
  • The below information is purely my personal experience and thoughts, as a patient, relating to using Continuous Subcutaneous Hydrocortisone Infusion, for treatment of Adrenal Insufficiency, using an insulin pump. (aiunited.org)
  • Whether an AI patient uses oral medication, subcutaneous injection or pump therapy, they have to remain just as vigilant to their symptoms for any type of delivery and understand the need for stress dosing. (aiunited.org)
  • A Continuous Subcutaneous Insulin Infusion Pump Uses Long-acting Insulins. (diabetestalk.net)
  • 7. A method according to claim 2 wherein the infusion is delivered by an infusion pump system comprising a controller and a pump and wherein parameters assigned in Step A are input to the controller by an operator. (google.com)
  • 8. A method according to claim 2 wherein the infusion is delivered by an infusion pump system comprising a controller and a pump and wherein parameters assigned in Step A are input to the controller by a reader device that reads those parameters from a source. (google.com)
  • An infusion pump includes a plurality of projections configured so that they enter the subcutaneous region of the patients skin and provides a painless means of creating a breach in the stratum corneum which is sealed against leakage by the skin surrounding each projection and provides a flow path for. (google.com.au)
  • In particular, the invention relates to an infusion pump that is adapted for use with prepackaged containers for delivering medications to patients from the container to the subcutaneous region of the patient via a catheter or needle, and to infusion needle array devices. (google.com.au)
  • The mixture is given by a slow injection into a vein (called an infusion) over an hour using a syringe-pump or with a drip. (drugs.com)
  • An implantable infusion pump (20) for infusing drugs or other chemicals or solutions into the body. (google.com)
  • A flexible spring diaphragm (25) forms an outer back wall portion (26) of a housing (22) of the infusion pump (20). (google.com)
  • e) a self-sealing penetrable member positioned in the inlet conduit, the self-sealing penetrable member being unobstructed so that the infusion pump can be implanted in the body with the unobstructed self-sealing penetrable member situated adjacent a surface area of the body whereby the drug chamber can be refilled with drug solution periodically by injection through the skin. (google.com)
  • 2. An infusion pump in accordance with claim 1, wherein the spring energy source means includes spring means for exerting a predetermined substantially constant force over a predetermined range of movement. (google.com)
  • 3. An infusion pump in accordance with claim 2, wherein the spring means includes spring diaphragm means for forming a movable external wall portion of the housing. (google.com)
  • 4. An infusion pump in accordance with claim 3, wherein the spring diaphragm means includes a conical spring member. (google.com)
  • 5. An infusion pump in accordance with claim 3, wherein the spring diaphragm means includes a plurality of conical spring sections interconnected by more stiff ring sections forming a spring diaphragm member. (google.com)
  • 6. An infusion pump in accordance with claim 3, wherein the spring diaphragm means includes a plurality of conical spring sections alternated radially with stronger conical sections reversely oriented. (google.com)
  • 8. An infusion pump in accordance with claim 7, wherein the spring diaphragm means exerts a substantially constant force over a predetermined range of movement. (google.com)
  • 9. An infusion pump in accordance with claim 8, wherein the infusion pump includes means for limiting movement of the spring diaphragm means whereby the spring diaphragm means is limited to a range of movements wherein the spring diaphragm means exerts a substantially constant force. (google.com)
  • Sixty-two patients with metastatic colorectal carcinoma involving the liver were treated by hepatic intra-arterial chemotherapy using an implantable infusion pump. (emmes.com)
  • May 10, 2019 (Heraldkeeper via COMTEX) -- Infusion Pump Market is valued around USD 11050.1 Million in 2018 and expected to reach USD 17916.2 Million by 2025 with the CAGR of 6.3% over the forecast period. (marketwatch.com)
  • So, during the study of Global infusion pump market, we have considered Product type and application to analyze the market. (marketwatch.com)
  • Global infusion pump market report is segmented on the basis of product type, application and end use and by regional & country level. (marketwatch.com)
  • Based upon product type, global infusion pump market is classified as ambulatory infusion pumps, implantable infusion pumps, syringe pumps, volumetric pumps and infusion disposable sets. (marketwatch.com)
  • Based upon end-users, global infusion pump market is classified as hospitals, ambulatory surgical centers and home care settings. (marketwatch.com)
  • The regions covered in this infusion pump market report are North America, Europe, Asia-Pacific and Rest of the World. (marketwatch.com)
  • The commercialization and growth of global infusion pump market over the past 25 years has been highly impactful. (marketwatch.com)
  • There is a company called Cellnovo which has launched a wireless hand held infusion pump controlled by patches worn on the body. (marketwatch.com)
  • Europe is expected to be the second largest growing region over the forecast period due to various technological advancements, increased health awareness among people coupled with increased prevalence of chronic disease are expected to promote the growth of infusion pump market. (marketwatch.com)
  • The CADD®-Solis Ambulatory Infusion Pump allows for patient mobility while providing clinicians with the confidence of reliable pump performance, accurate medication delivery and an easy-to-use, patient friendly system. (smiths-medical.com)
  • Reliable CADD® smart pump technology meets infusion pump guidelines to promote patient safety and reduce the risk of medication delivery errors. (smiths-medical.com)
  • The software is designed to safely and effectively program and collect data from the CADD®-Solis Ambulatory Infusion pump. (smiths-medical.com)
  • In this month's edition of What's Hot in Parkinson's disease, we examine the results of the recently completed apomorphine TOLEDO pump trial, a new study examining subcutaneous apomorphine infusion (a pump therapy that delivers PD medication similar to insulin pumps for diabetes). (parkinson.org)
  • The infusion set can remain in the place for three days while the pump is clip-belt worn. (wikipedia.org)
  • Another option is to get a continuous infusion of medicine into your body through a battery-powered pump. (webmd.com)
  • 0JHN0VZ is a billable procedure code used to specify the performance of insertion of infusion pump into right lower leg subcutaneous tissue and fascia, open approach. (icdlist.com)
  • It s the same kind of pump that s used by tens of thousands of diabetics who get their insulin by micro-infusion every day. (latimes.com)
  • The aim of this study is to compare the effects of tablet treatment, circadian and combined circadian and ultradian subcutaneous hydrocortisone infusion on steroid metabolism and tissue responses to therapy. (clinicaltrials.gov)
  • This is a pilot trial with an open cross-over design of 3 x minimum 2 weeks in 10 patients comparing the effects of tablet treatment versus continuous subcutaneous hydrocortisone infusion versus ultradian subcutaneous hydrocortisone infusion on serum, salivary, tissue hormonal response and glucocorticoid related gene expression. (clinicaltrials.gov)
  • Regulation of uncoupling protein-2 and uncoupling protein-3 mRNA expression during lipid infusion in human skeletal muscle and subcutaneous adipose tissue. (diabetesjournals.org)
  • The mRNA levels of UCP-2 and of the short (UCP-3S) and long (UCP-3L) isoforms of UCP-3 were quantified by reverse transcription-competitive polymerase chain reaction in tissue biopsies taken before and at the end of the infusion periods. (diabetesjournals.org)
  • In contrast, the expression of UCP-2 was not affected by lipid infusion in skeletal muscle or in subcutaneous adipose tissue. (diabetesjournals.org)
  • Measurements of cefuroxime were obtained every 30 min in plasma, subcutaneous tissue, and bone. (asm.org)
  • Except for subcutaneous tissue in the short-term infusion group, the tissue penetration was incomplete for all tissues. (asm.org)
  • For short-term infusion, the tissue penetration ratios were 0.97 (95% confidence interval [CI], 0.67 to 1.39), 0.61 (95% CI, 0.51 to 0.73), and 0.45 (95% CI, 0.36 to 0.56) for subcutaneous tissue, cancellous bone, and cortical bone, respectively. (asm.org)
  • however, incomplete tissue penetration and high MIC strains may jeopardize the continuous infusion approach. (asm.org)
  • In the clinical trials there were no observable changes in the skin or subcutaneous tissue in almost 3000 infusions and maximum exposure of over 3 years. (hyqvia.com)
  • Hypodermoclysis is a method of infusing fluid into subcutaneous tissue that requires only minimal equipment. (aafp.org)
  • Introduction: Subcutaneous fat necrosis (SFN) of the newborn is an inflammatory disorder of the adipose tissue that rarely disease which may be complicated with potentially life-threatening hypercalcemia. (eurospe.org)
  • A novel catheter apparatus for use in delivering an anesthetic agent or other fluid medicament to the portion of subcutaneous tissue through which a catheter device has been inserted into a patient, thereby allowing the catheter device to be retracted without causing pain or discomfort to the patient. (google.co.uk)
  • The catheter device has an indwelling cannula adapted for insertion through subcutaneous tissue into a patient's body. (google.co.uk)
  • A sheath is selectively disposed about the cannula so as to be positioned within the subcutaneous tissue once the cannula has been inserted into the body. (google.co.uk)
  • The delivery holes permit the anesthetic agent or fluid medicament to be delivered to the subcutaneous tissue. (google.co.uk)
  • The procedure code 0JHN0VZ is in the medical and surgical section and is part of the subcutaneous tissue and fascia body system, classified under the insertion operation. (icdlist.com)
  • The applicable bodypart is subcutaneous tissue and fascia, right lower leg. (icdlist.com)
  • APIDRA may be administered by continuous subcutaneous infusion in the abdominal wall. (rxlist.com)
  • The relatively short half-lives of most β-lactams suggest that continuous infusion of these time-dependent antimicrobials may be favorable compared to short-term infusion. (asm.org)
  • In this study, we randomly assigned 12 pigs to receive cefuroxime as either a short-term or continuous infusion. (asm.org)
  • The absolute areas under the concentration-time curve were also lower in the continuous infusion group. (asm.org)
  • Nevertheless, a significantly longer time with concentrations above the MIC was found for continuous infusion up until MICs of 4, 2, 2, and 0.5 μg/ml for plasma and the same three tissues mentioned above, respectively. (asm.org)
  • Continuous infusion followed by subcutaneous injection of campath-1H [alemtuzumab] plus rituximab in the treatment of CD52- and CD20-positive refractory or relapsed chronic lymphoid disorders. (springer.com)
  • Continuous infusion of GH resulted in an increase in cholesterol and apo E in serum and HDL to the levels of intact females. (biomedsearch.com)
  • Meanwhile, the results of the FeDeriCa study, led by Tan and colleagues, is being used to support a recent filing for a Biologic License Application with the FDA for the fixed-dose combination of pertuzumab and trastuzumab administered by subcutaneous injection in combination with intravenous chemotherapy for the treatment of patients with HER2-positive breast cancer. (lww.com)
  • Specifically there has been a change to the recommendation on the use of continuous subcutaneous insulin infusion in children younger than 12 years with type 1 diabetes mellitus. (mims.co.uk)
  • Health-related quality of life in paediatric patients with Type 1 diabetes mellitus using insulin infusion systems. (semanticscholar.org)
  • This fixed-dose subcutaneous combination has the potential to provide a quicker and less invasive method of administration for people with HER2-positive breast cancer being treated with Perjeta and Herceptin," said Levi Garraway, M.D., Ph.D., chief medical officer and head of Global Product Development. (businesswire.com)
  • Factors such as rising healthcare expenditure related to diabetes and favorable reimbursement policies for insulin pumps are contributing to the growth of the market for continuous subcutaneous insulin infusion. (grandviewresearch.com)
  • We describe a series of five patients with ADH in whom stabilization of calcium concentrations could not be achieved with conventional treatment and in whom continuous subcutaneous PTH infusion (CSPI) using insulin pumps was started. (endocrine-abstracts.org)
  • Infusion sets and pumps are used to deliver various types of solutions subcutaneously to patients. (google.com.au)
  • however, this difficulty has recently been overcome to some extent by the development of high-concentration solutions, the use of infusion pumps, and the coadministration of the dispersion enhancer hyaluronidase. (springer.com)
  • Infusion Pumps are external devices used to deliver medications, fluids and other nutrients in the patient's body. (marketwatch.com)
  • Increase in the prevalence of chronic disease such as cancer, Alzheimer disease and others coupled with pain management are the major factors driving the growth of infusion pumps market in the near future. (marketwatch.com)
  • Moreover, increasing in the home healthcare trends in the industry has also increased the demand for infusion pumps. (marketwatch.com)
  • However, high cost associated with ambulatory implantable devices is expected to slow down the growth of infusion pumps treatment market. (marketwatch.com)
  • Ambulatory infusion smart pumps safely deliver medication to patients in hospital, home care and alternative care facilities. (smiths-medical.com)
  • subcutaneous administration could further simplify drug delivery with the development of fixed-dose combinations or ready-to-use devices that deliver two or more biotherapeutics via one single subcutaneous injection. (springer.com)
  • This is the first time that we have brought together two of our targeted antibodies as a single subcutaneous injection that can be administered in just minutes. (businesswire.com)
  • View cart "IV Catheter 23G Winged Infusion Set" has been added to your cart. (whelpingsupplies.com.au)
  • An improved catheter includes a double spiral configuration of infusion holes around the circumference and along the length of the catheter which provides an improved lateral dispersion of a thrombolytic fluid to more completely and quickly lyse a clot through which the catheter is passing. (google.es)
  • 6. A catheter as recited in claim 1 , wherein said infusion holes belong to a plurality of successive groups of holes. (google.es)
  • This "infusion set" is patient-connected via a catheter to the abdomen region. (wikipedia.org)
  • One way to accomplish this is through product optimization, which can be achieved in several ways, including the development of subcutaneous formulations or oral administration of drugs, as well as self-injectable devices. (lww.com)
  • The only significant side effect observed during these years was the development of subcutaneous nodules with occasional insufficient control of calcemia. (biomedsearch.com)
  • We conclude that increased plasma NEFA levels by lipid infusion for 5 h induces the expression of UCP-3 but not UCP-2 in humans. (diabetesjournals.org)
  • An injector device has a plunger with a medical needle essentially non-detachably secured thereto, preferably a solid needle incapable of delivering a fluid, and is adapted for the quick and easy transcutaneous placement through the skin of a patient of the cannula of a subcutaneous infusion set, the insertion needle extending through the infusion set and protruding from the end of the cannula. (patents.com)
  • Andrew Dickman and Jennifer Schneider [have] produced a well-written, well-referenced, and efficient treatment of the modern syringe driver for subcutaneous infusions as used in palliative care. (oup.com)
  • an important addition to the bookshelf of any palliative care clinician, nursing or medical, whose patients require continuous subcutaneous infusion. (oup.com)
  • Her long-felt desire to deliver patient-centric care and provide improved access to it would one day help inspire her to lead a study demonstrating the efficacy and safety of a significantly faster and less-invasive alternative to intravenous infusion of two medicines used to treat HER2-positive breast cancer. (lww.com)
  • Subcutaneous delivery of biotherapeutics has become a valuable alternative to intravenous administration across many disease areas. (springer.com)
  • When the first subcutaneous monoclonal antibodies (mAbs) in oncology were developed as an alternative to intravenous infusions [ 1 ], this delivery approach for biotherapeutics was already established in several disease areas, including diabetes, rheumatoid arthritis (RA), multiple sclerosis (MS), and primary immunodeficiency (PI). (springer.com)
  • The infusion included 750 IU of hyaluronidase, and the saline infusion rate was 167 mL per hour. (aafp.org)
  • For continuous subcutaneous insulin infusion, the insulins of choice are the rapid-acting insulin analogues, insulin aspart, insulin lispro and insulin glulisine. (diabetestalk.net)
  • 4. The injector device of claim 2, wherein the infusion set (14, 114, 214) comprises a tubing (113), said injector device including an annular space (115) between said device housing (28, 128, 228) and said plunger (30, 130, 230) for accommodating said tubing (113). (patents.com)
  • This device is harnessing a large amount of data and creating more opportunities in the market for continuous subcutaneous insulin infusion. (grandviewresearch.com)
  • This low dose was used to ensure tolerability and documentation of side effects related to both infusion device and medication. (imj.ie)
  • So much can depend on a subcutaneous micro-infusion device. (latimes.com)
  • It s delivered with a micro-infusion device. (latimes.com)
  • The efficacy and safety of switching between intravenous and subcutaneous formulations and routes of administration have not been established. (rxlist.com)
  • Although the pharmacokinetic profiles of subcutaneous and intravenous formulations differ, subcutaneous administration has proven effective, safe, well-tolerated, generally preferred by patients and healthcare providers and to result in reduced drug delivery-related healthcare costs and resource use. (springer.com)
  • This is compared to approximately 150 minutes for infusion of a loading dose of Perjeta and Herceptin using the standard IV formulations, and between 60-150 minutes for subsequent maintenance infusions of the two medicines. (businesswire.com)
  • Tan, who led the study, "Subcutaneous administration of the fixed-dose combination of trastuzumab and pertuzumab in combination with chemotherapy in HER2-positive early breast cancer: Primary analysis of the phase III, multicenter, randomized, open-label, two-arm FeDeriCa study," presented the results in December 2019 at the San Antonio Breast Cancer Symposium. (lww.com)
  • In this study, Tan and her co-investigators showed that a fixed-dose formulation of pertuzumab and trastuzumab delivered in a single injection over just 5-8 minutes is as safe and as effective as administering the monoclonal antibodies for treatment of HER2-positive breast cancer via IV infusion, which takes up to 2.5 hours for the loading doses and about 60-90 minutes for the maintenance doses. (lww.com)
  • It dates back to a London Hospital medical student thesis in 1934, which reported a blood glucose decrease when a few diabetic patients were given subcutaneous insulin over a few hours. (aappublications.org)
  • Treprostinil subcutaneous (under the skin) infusion is a very good medication for treating pulmonary arterial hypertension but infusion site pain may be very severe in some patients. (clinicaltrials.gov)
  • Subcutaneous Infusion - The administration of liquid medication or nutrients under the skin, usually over minutes or hours. (orcexperts.com)
  • Continuous subcutaneous apomorphine infusion (CSAI) is a well-recognized therapeutic option for the management of motor fluctuations in Parkinson's disease (PD), although clinical experience suggests that most patients discontinue CSAI after a variable amount of time due to several causes and circumstances. (elsevier.com)
  • The purpose of this guideline is to provide guidance about intravenous and subcutaneous immunoglobulin infusions at Great Ormond Street Hospital (GOSH). (gosh.nhs.uk)
  • The infusion cap ( 54 ) also comprises a hard cannula ( 170 ) adapted to be inserted through the septum ( 130 ) and to place said soft cannula ( 52 ) in fluid communication with said lumen ( 160 ). (google.ca)
  • 3. The infusion set of claim 1 , wherein the guide section surrounds the infusion cannula. (google.ca)
  • 4. The infusion set of claim 1 , wherein the guide section and the cannula are substantially co-axial. (google.ca)
  • 4 . The system of claim 3 wherein the second cannula is connected to the housing by an infusion tubing. (google.es)
  • 9 . The system of claim 1 wherein when the second cannula is transcutaneously positioned, the first cannula is withdrawn from the first infusion site. (google.es)
  • Here you'll find information on what to expect with HYQVIA [Immune Globulin Infusion 10% (Human) with Recombinant Human Hyaluronidase]. (hyqvia.com)
  • If you have questions about HYQVIA [Immune Globulin Infusion 10% (Human) with Recombinant Human Hyaluronidase] infusions or would like to request a training kit, call a Nurse Advocate at 1-855-250-5111 . (hyqvia.com)
  • Following your infusion with HYQVIA [Immune Globulin Infusion 10% (Human) with Recombinant Human Hyaluronidase], it's not uncommon to experience a temporary, soft swelling at the infusion site. (hyqvia.com)
  • And, finally, the efficacy of pembrolizumab intravenous (IV) infusion administration will be assessed. (centerwatch.com)
  • Efficacy and Safety of Long Term Treatment of Unresponsive Hypoparathyroidism Using Multipulse Subcutaneous Infusion of Teriparatide. (biomedsearch.com)
  • FeDeriCa is an international, multicenter, two-arm, randomized, open-label, Phase III study evaluating the pharmacokinetics, efficacy and safety of SC injection of the FDC of Perjeta and Herceptin in combination with chemotherapy, compared with standard IV infusions of Perjeta and Herceptin in combination with chemotherapy in 500 people with HER2-positive EBC who are being treated in the neoadjuvant (before surgery) and adjuvant (after surgery) settings. (businesswire.com)
  • Biologics come in two forms-as a self- INJECTION and as an intravenous INFUSION given in a doctor's office, hospital or infusion center. (healthguru.com)
  • Programmable infusion systems and method for controlled infusion of diagnostic or therapeutic substances (e.g., drugs, biologics, fluids, cell preparations, etc.) into the bodies of human or animal subjects. (google.com)
  • SAN MATEO, Calif., Oct. 18, 2011 /PRNewswire/ -- Nile Therapeutics, Inc. (OTCQB: NLTX), a biopharmaceutical company that develops novel therapeutics for heart failure patients, today announced that it has completed patient dosing of an open-label Phase I clinical trial evaluating pharmacokinetics (PK), pharmacodynamics (PD), safety and tolerability of subcutaneous bolus and subcutaneous infusion of cenderitide in patients with chronic heart failure. (bio-medicine.org)
  • The purpose of this study is to characterize the pharmacokinetic (PK) profile of pembrolizumab (MK-3475) following single subcutaneous (SC) injection of pembrolizumab Dose A versus pembrolizumab Dose C in adults with advanced melanoma. (centerwatch.com)
  • Lisuride sc (Nenad(R) Powder for solution for sc infusion) was developed for the treatment of patients in an advanced stage of Parkinson's Disease. (medicalnewstoday.com)
  • It can be used intravenous, subcutaneous and arterial routes. (marketwatch.com)
  • Subcutaneous Treatment vs. IV Infusion for HER2-Positive Bre. (lww.com)
  • To achieve patient-centric care, one can start to evaluate ways in which patients can spend less time in a treatment chair getting an infusion, and look at models of care where there is a shift to administering anticancer therapy outside of the infusion center to home-based cancer care," Tan explained. (lww.com)
  • Current studies conclude that constant or unphysiological administration of glucocorticoids leads to abnormal gene transcription and causes sides effect of glucocorticoids treatment and long standing complications Glucocorticoid replacement is technically feasible by continuous subcutaneous hydrocortisone infusion, which can mimic not only the normal diurnal cortisol rhythm, but potentially also the ultradian cadence. (clinicaltrials.gov)
  • Conclusion: We describe continuous subcutaneous PTH infusion as a suitable treatment for ADH that cannot be controlled conventionally. (endocrine-abstracts.org)
  • The review and re-appraisal of the use of continuous subcutaneous insulin infusion for the treatment of diabetes mellitus has resulted in a change in the guidance. (mims.co.uk)
  • Continuous Subcutaneous Insulin Infusion for the Treatment of Diabetes Mellitus (review of technology appraisal guidance 57). (mims.co.uk)
  • Learn more about the HYQVIA Ramp-Up period, how to start treatment, and view real patient photos of what a HYQVIA infusion looks like. (hyqvia.com)
  • Once the ramp-up period has been completed, your treatment schedule is one infusion, one time a month. (hyqvia.com)
  • You should let your doctor know if you are breast-feeding or want to start breast-feeding while you are having treatment with aciclovir for infusion. (drugs.com)
  • Subcutaneous medications for diabetes, RA, MS, or PI can be administered in the home by patients or caregivers, but biotherapeutics for cancer treatment are yet to be approved for administration outside a designated healthcare setting. (springer.com)
  • Prior to the recently published TOLEDO trial, subcutaneous apomorphine infusion had only been tested in open-label studies, which lacked control groups or the use of a placebo to more accurately test the treatment. (parkinson.org)
  • The intravenous infusions, cardiovascular drugs, anti-anemics, hemostatics, and anticoagulants are described as to their effects and functions. (elsevier.com)
  • The name of your medicine is Aciclovir 250mg Powder for Solution for Infusion. (drugs.com)
  • FEIBA is presented as powder and solvent to prepare a solution for infusion containing 200- 600 mg human plasma protein with a Factor Eight Inhibitor Bypassing Activity of 500 U* per vial. (medicines.org.uk)
  • Powder and solvent for solution for infusion. (medicines.org.uk)
  • Lisuride, the active principle of Nenad(R), is a potent dopamine agonist which in its parenteral forms (transdermal patch and sc infusion) has been developed to provide continuous dopaminergic stimulation (CDS). (medicalnewstoday.com)
  • The usual adult dose of Aciclovir for Infusion is 5mg per kg bodyweight every eight hours for five days. (drugs.com)
  • Furthermore, given the increasing number of biotherapeutics being considered for combination therapy and the high dosing complexity associated with these, especially when administered intravenously, subcutaneous delivery of fixed-dose combinations might be an alternative that will diminish these burdens on healthcare systems. (springer.com)
  • The investigators plan to treat patients receiving treprostinil with a subcutaneous infusion of lidocaine (a local anesthestic) to treat the pain. (clinicaltrials.gov)
  • Twenty-six (49%) of the 53 patients developed hepatitis during infusion chemotherapy, which resolved after temporary cessation of the chemotherapy. (emmes.com)
  • Eleven patients had evidence of peptic ulceration by endoscopic examination during the infusion chemotherapy. (emmes.com)
  • APIDRA given by subcutaneous injection should generally be used in regimens with an intermediate or long-acting insulin. (rxlist.com)
  • Assessment of therapy with continuous subcutaneous insulin infusion in an academic diabetes clinic. (nih.gov)
  • This teaching clinic provides consultations, education, support for patients choosing SCIG home infusion therapy throughout BC. (providencehealthcare.org)
  • Continuous subcutaneous insulin infusion is a mode of delivering intensive insulin therapy, which leads to improving glucose control. (grandviewresearch.com)
  • Continuous subcutaneous insulin infusion therapy is the most recommended option for type 1 patients to achieve target hemoglobin (HbA1c) level. (grandviewresearch.com)
  • Thompson, BM & Cook, CB 2015, ' EMPLOYING CONTINUOUS SUBCUTANEOUS INSULIN INFUSION THERAPY IN THE OPERATING SUITE: CURRENT STATE AND FUTURE DIRECTIONS ', Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists , vol. 21, no. 11, pp. 1306-1308. (elsevier.com)
  • Continuous subcutaneous infusion of terbutaline (CSIT) has been shown to be beneficial as add-on therapy in uncontrolled asthmatics. (imj.ie)
  • Conclusions: We report a 47-day-old baby who developed subcutaneous fat necrosis presented with symptomatic hypercalcemia which successfully treated with pamidronate infusion therapy. (eurospe.org)
  • However, insulin therapy may be conducted without CGM and although there is not yet an automated insulin-regulation feedback mechanism between measure and infusion to control the amount and timing of insulin, this is clearly a future objective. (wikipedia.org)