Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.
Molecular products metabolized and secreted by neoplastic tissue and characterized biochemically in cells or body fluids. They are indicators of tumor stage and grade as well as useful for monitoring responses to treatment and predicting recurrence. Many chemical groups are represented including hormones, antigens, amino and nucleic acids, enzymes, polyamines, and specific cell membrane proteins and lipids.
A phenotypically recognizable genetic trait which can be used to identify a genetic locus, a linkage group, or a recombination event.
Soluble protein fragments formed by the proteolytic action of plasmin on fibrin or fibrinogen. FDP and their complexes profoundly impair the hemostatic process and are a major cause of hemorrhage in intravascular coagulation and fibrinolysis.
Sialylated Lewis blood group carbohydrate antigen found in many adenocarcinomas of the digestive tract, especially pancreatic tumors.
A glycoprotein that is secreted into the luminal surface of the epithelia in the gastrointestinal tract. It is found in the feces and pancreaticobiliary secretions and is used to monitor the response to colon cancer treatment.
Carbohydrate antigens expressed by malignant tissue. They are useful as tumor markers and are measured in the serum by means of a radioimmunoassay employing monoclonal antibodies.
Carbohydrate antigen most commonly seen in tumors of the ovary and occasionally seen in breast, kidney, and gastrointestinal tract tumors and normal tissue. CA 125 is clearly tumor-associated but not tumor-specific.
A high-molecular-weight plasma protein, produced by endothelial cells and megakaryocytes, that is part of the factor VIII/von Willebrand factor complex. The von Willebrand factor has receptors for collagen, platelets, and ristocetin activity as well as the immunologically distinct antigenic determinants. It functions in adhesion of platelets to collagen and hemostatic plug formation. The prolonged bleeding time in VON WILLEBRAND DISEASES is due to the deficiency of this factor.
In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test.
A plasma protein that circulates in increased amounts during inflammation and after tissue damage.
Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.
The residual portion of BLOOD that is left after removal of BLOOD CELLS by CENTRIFUGATION without prior BLOOD COAGULATION.
Single pavement layer of cells which line the luminal surface of the entire vascular system and regulate the transport of macromolecules and blood components.
Serological tumor marker composed of a molecular complex of cytokeratins 8, 18, and 19. It is used in the diagnosis and staging of bronchogenic carcinoma.
A member of the serpin family of proteins. It inhibits both the tissue-type and urokinase-type plasminogen activators.
A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.
The first alpha-globulins to appear in mammalian sera during FETAL DEVELOPMENT and the dominant serum proteins in early embryonic life.
A type I keratin found associated with KERATIN-7 in ductal epithelia and gastrointestinal epithelia.
Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.
Proteins, glycoprotein, or lipoprotein moieties on surfaces of tumor cells that are usually identified by monoclonal antibodies. Many of these are of either embryonic or viral origin.
A disturbance in the prooxidant-antioxidant balance in favor of the former, leading to potential damage. Indicators of oxidative stress include damaged DNA bases, protein oxidation products, and lipid peroxidation products (Sies, Oxidative Stress, 1991, pxv-xvi).
A cell line derived from cultured tumor cells.
Carbohydrate antigen elevated in patients with tumors of the breast, ovary, lung, and prostate as well as other disorders. The mucin is expressed normally by most glandular epithelia but shows particularly increased expression in the breast at lactation and in malignancy. It is thus an established serum marker for breast cancer.
An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.
Serum glycoprotein produced by activated MACROPHAGES and other mammalian MONONUCLEAR LEUKOCYTES. It has necrotizing activity against tumor cell lines and increases ability to reject tumor transplants. Also known as TNF-alpha, it is only 30% homologous to TNF-beta (LYMPHOTOXIN), but they share TNF RECEPTORS.
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
The total amount (cell number, weight, size or volume) of tumor cells or tissue in the body.
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.
Methods which attempt to express in replicable terms the extent of the neoplasm in the patient.
A malignant epithelial tumor with a glandular organization.
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.
Elements of limited time intervals, contributing to particular results or situations.
Tumors or cancer of the LIVER.
Tumors or cancer of the TESTIS. Germ cell tumors (GERMINOMA) of the testis constitute 95% of all testicular neoplasms.
A usually small, slow-growing neoplasm composed of islands of rounded, oxyphilic, or spindle-shaped cells of medium size, with moderately small vesicular nuclei, and covered by intact mucosa with a yellow cut surface. The tumor can occur anywhere in the gastrointestinal tract (and in the lungs and other sites); approximately 90% arise in the appendix. It is now established that these tumors are of neuroendocrine origin and derive from a primitive stem cell. (From Stedman, 25th ed & Holland et al., Cancer Medicine, 3d ed, p1182)
Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS.
Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Neoplasms composed of primordial GERM CELLS of embryonic GONADS or of elements of the germ layers of the EMBRYO, MAMMALIAN. The concept does not refer to neoplasms located in the gonads or present in an embryo or FETUS.
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Nuclear phosphoprotein encoded by the p53 gene (GENES, P53) whose normal function is to control CELL PROLIFERATION and APOPTOSIS. A mutant or absent p53 protein has been found in LEUKEMIA; OSTEOSARCOMA; LUNG CANCER; and COLORECTAL CANCER.
Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).
Tumors or cancer of the human BREAST.
Tumors whose cells possess secretory granules and originate from the neuroectoderm, i.e., the cells of the ectoblast or epiblast that program the neuroendocrine system. Common properties across most neuroendocrine tumors include ectopic hormone production (often via APUD CELLS), the presence of tumor-associated antigens, and isozyme composition.
Proteins whose abnormal expression (gain or loss) are associated with the development, growth, or progression of NEOPLASMS. Some neoplasm proteins are tumor antigens (ANTIGENS, NEOPLASM), i.e. they induce an immune reaction to their tumor. Many neoplasm proteins have been characterized and are used as tumor markers (BIOMARKERS, TUMOR) when they are detectable in cells and body fluids as monitors for the presence or growth of tumors. Abnormal expression of ONCOGENE PROTEINS is involved in neoplastic transformation, whereas the loss of expression of TUMOR SUPPRESSOR PROTEINS is involved with the loss of growth control and progression of the neoplasm.
A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.
The transfer of a neoplasm from one organ or part of the body to another remote from the primary site.
A hydro-lyase that catalyzes the dehydration of 2-phosphoglycerate to form PHOSPHOENOLPYRUVATE. Several different isoforms of this enzyme exist, each with its own tissue specificity.
A malignant kidney tumor, caused by the uncontrolled multiplication of renal stem (blastemal), stromal (STROMAL CELLS), and epithelial (EPITHELIAL CELLS) elements. However, not all three are present in every case. Several genes or chromosomal areas have been associated with Wilms tumor which is usually found in childhood as a firm lump in a child's side or ABDOMEN.
Experimentally induced new abnormal growth of TISSUES in animals to provide models for studying human neoplasms.
Genes that inhibit expression of the tumorigenic phenotype. They are normally involved in holding cellular growth in check. When tumor suppressor genes are inactivated or lost, a barrier to normal proliferation is removed and unregulated growth is possible.
Neoplasms of the intracranial components of the central nervous system, including the cerebral hemispheres, basal ganglia, hypothalamus, thalamus, brain stem, and cerebellum. Brain neoplasms are subdivided into primary (originating from brain tissue) and secondary (i.e., metastatic) forms. Primary neoplasms are subdivided into benign and malignant forms. In general, brain tumors may also be classified by age of onset, histologic type, or presenting location in the brain.
The determination of the pattern of genes expressed at the level of GENETIC TRANSCRIPTION, under specific circumstances or in a specific cell.
A class of fibrous proteins or scleroproteins that represents the principal constituent of EPIDERMIS; HAIR; NAILS; horny tissues, and the organic matrix of tooth ENAMEL. Two major conformational groups have been characterized, alpha-keratin, whose peptide backbone forms a coiled-coil alpha helical structure consisting of TYPE I KERATIN and a TYPE II KERATIN, and beta-keratin, whose backbone forms a zigzag or pleated sheet structure. alpha-Keratins have been classified into at least 20 subtypes. In addition multiple isoforms of subtypes have been found which may be due to GENE DUPLICATION.
Antibodies produced by a single clone of cells.
All of the processes involved in increasing CELL NUMBER including CELL DIVISION.
Established cell cultures that have the potential to propagate indefinitely.
In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.
Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.
The worsening of a disease over time. This concept is most often used for chronic and incurable diseases where the stage of the disease is an important determinant of therapy and prognosis.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
Specialized forms of antibody-producing B-LYMPHOCYTES. They synthesize and secrete immunoglobulin. They are found only in lymphoid organs and at sites of immune responses and normally do not circulate in the blood or lymph. (Rosen et al., Dictionary of Immunology, 1989, p169 & Abbas et al., Cellular and Molecular Immunology, 2d ed, p20)
Immunologic techniques based on the use of: (1) enzyme-antibody conjugates; (2) enzyme-antigen conjugates; (3) antienzyme antibody followed by its homologous enzyme; or (4) enzyme-antienzyme complexes. These are used histologically for visualizing or labeling tissue specimens.
Tumors or cancer of the LUNG.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
A carcinoma derived from stratified SQUAMOUS EPITHELIAL CELLS. It may also occur in sites where glandular or columnar epithelium is normally present. (From Stedman, 25th ed)
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
Proteins that are normally involved in holding cellular growth in check. Deficiencies or abnormalities in these proteins may lead to unregulated cell growth and tumor development.
The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.
An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.
The local recurrence of a neoplasm following treatment. It arises from microscopic cells of the original neoplasm that have escaped therapeutic intervention and later become clinically visible at the original site.
A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.
The lipid- and protein-containing, selectively permeable membrane that surrounds the cytoplasm in prokaryotic and eukaryotic cells.
A variety of simple repeat sequences that are distributed throughout the GENOME. They are characterized by a short repeat unit of 2-8 basepairs that is repeated up to 100 times. They are also known as short tandem repeats (STRs).
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
A pathologic process consisting of the proliferation of blood vessels in abnormal tissues or in abnormal positions.
A graphic means for assessing the ability of a screening test to discriminate between healthy and diseased persons; may also be used in other studies, e.g., distinguishing stimuli responses as to a faint stimuli or nonstimuli.
The statistical reproducibility of measurements (often in a clinical context), including the testing of instrumentation or techniques to obtain reproducible results. The concept includes reproducibility of physiological measurements, which may be used to develop rules to assess probability or prognosis, or response to a stimulus; reproducibility of occurrence of a condition; and reproducibility of experimental results.
Proteins secreted by the epididymal epithelium. These proteins are both tissue- and species-specific. They are important molecular agents in the process of sperm maturation.
Tumors or cancer of the COLON.
The fission of a CELL. It includes CYTOKINESIS, when the CYTOPLASM of a cell is divided, and CELL NUCLEUS DIVISION.
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
The milieu surrounding neoplasms consisting of cells, vessels, soluble factors, and molecules, that can influence and be influenced by, the neoplasm's growth.
DNA present in neoplastic tissue.
Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
Tumors or cancer of the GASTROINTESTINAL TRACT, from the MOUTH to the ANAL CANAL.
The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.
Hybridization of a nucleic acid sample to a very large set of OLIGONUCLEOTIDE PROBES, which have been attached individually in columns and rows to a solid support, to determine a BASE SEQUENCE, or to detect variations in a gene sequence, GENE EXPRESSION, or for GENE MAPPING.
Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs.
Technique using an instrument system for making, processing, and displaying one or more measurements on individual cells obtained from a cell suspension. Cells are usually stained with one or more fluorescent dyes specific to cell components of interest, e.g., DNA, and fluorescence of each cell is measured as it rapidly transverses the excitation beam (laser or mercury arc lamp). Fluorescence provides a quantitative measure of various biochemical and biophysical properties of the cell, as well as a basis for cell sorting. Other measurable optical parameters include light absorption and light scattering, the latter being applicable to the measurement of cell size, shape, density, granularity, and stain uptake.
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in neoplastic tissue.
Experimentally induced mammary neoplasms in animals to provide a model for studying human BREAST NEOPLASMS.
The proportion of survivors in a group, e.g., of patients, studied and followed over a period, or the proportion of persons in a specified group alive at the beginning of a time interval who survive to the end of the interval. It is often studied using life table methods.
The relationship between the dose of an administered drug and the response of the organism to the drug.
Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.
A class of statistical procedures for estimating the survival function (function of time, starting with a population 100% well at a given time and providing the percentage of the population still well at later times). The survival analysis is then used for making inferences about the effects of treatments, prognostic factors, exposures, and other covariates on the function.
Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.
Any method used for determining the location of and relative distances between genes on a chromosome.
Proteins which are found in membranes including cellular and intracellular membranes. They consist of two types, peripheral and integral proteins. They include most membrane-associated enzymes, antigenic proteins, transport proteins, and drug, hormone, and lectin receptors.
The range or frequency distribution of a measurement in a population (of organisms, organs or things) that has not been selected for the presence of disease or abnormality.
A radiosensitive, malignant neoplasm of the testis, thought to be derived from primordial germ cells of the sexually undifferentiated embryonic gonad. There are three variants: classical (typical), the most common type; anaplastic; and spermatocytic. The classical seminoma is composed of fairly well differentiated sheets or cords of uniform polygonal or round cells (seminoma cells), each cell having abundant clear cytoplasm, distinct cell membranes, a centrally placed round nucleus, and one or more nucleoli. In the female, a grossly and histologically identical neoplasm, known as dysgerminoma, occurs. (Dorland, 27th ed)
A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.
Tumors or cancer located in bone tissue or specific BONES.
Transplantation between animals of different species.
Tomography using x-ray transmission and a computer algorithm to reconstruct the image.
Tumors or cancers of the KIDNEY.
Substances that inhibit or prevent the proliferation of NEOPLASMS.
A type of chromogranin which was first isolated from CHROMAFFIN CELLS of the ADRENAL MEDULLA but is also found in other tissues and in many species including human, bovine, rat, mouse, and others. It is an acidic protein with 431 to 445 amino acid residues. It contains fragments that inhibit vasoconstriction or release of hormones and neurotransmitter, while other fragments exert antimicrobial actions.
A CELL CYCLE and tumor growth marker which can be readily detected using IMMUNOCYTOCHEMISTRY methods. Ki-67 is a nuclear antigen present only in the nuclei of cycling cells.
A gonadotropic glycoprotein hormone produced primarily by the PLACENTA. Similar to the pituitary LUTEINIZING HORMONE in structure and function, chorionic gonadotropin is involved in maintaining the CORPUS LUTEUM during pregnancy. CG consists of two noncovalently linked subunits, alpha and beta. Within a species, the alpha subunit is virtually identical to the alpha subunits of the three pituitary glycoprotein hormones (TSH, LH, and FSH), but the beta subunit is unique and confers its biological specificity (CHORIONIC GONADOTROPIN, BETA SUBUNIT, HUMAN).
A family of serine proteinase inhibitors which are similar in amino acid sequence and mechanism of inhibition, but differ in their specificity toward proteolytic enzymes. This family includes alpha 1-antitrypsin, angiotensinogen, ovalbumin, antiplasmin, alpha 1-antichymotrypsin, thyroxine-binding protein, complement 1 inactivators, antithrombin III, heparin cofactor II, plasminogen inactivators, gene Y protein, placental plasminogen activator inhibitor, and barley Z protein. Some members of the serpin family may be substrates rather than inhibitors of SERINE ENDOPEPTIDASES, and some serpins occur in plants where their function is not known.
The uptake of naked or purified DNA by CELLS, usually meaning the process as it occurs in eukaryotic cells. It is analogous to bacterial transformation (TRANSFORMATION, BACTERIAL) and both are routinely employed in GENE TRANSFER TECHNIQUES.
The beta subunit of human CHORIONIC GONADOTROPIN. Its structure is similar to the beta subunit of LUTEINIZING HORMONE, except for the additional 30 amino acids at the carboxy end with the associated carbohydrate residues. HCG-beta is used as a diagnostic marker for early detection of pregnancy, spontaneous abortion (ABORTION, SPONTANEOUS); ECTOPIC PREGNANCY; HYDATIDIFORM MOLE; CHORIOCARCINOMA; or DOWN SYNDROME.
Form of radioimmunoassay in which excess specific labeled antibody is added directly to the test antigen being measured.
Conjugated protein-carbohydrate compounds including mucins, mucoid, and amyloid glycoproteins.
Transfer of a neoplasm from its primary site to lymph nodes or to distant parts of the body by way of the lymphatic system.
Exfoliate neoplastic cells circulating in the blood and associated with metastasizing tumors.
Tumors or cancer of the STOMACH.
A malignant neoplasm of the germinal tissue of the GONADS; MEDIASTINUM; or pineal region. Germinomas are uniform in appearance, consisting of large, round cells with vesicular nuclei and clear or finely granular eosinophilic-staining cytoplasm. (Stedman, 265th ed; from DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, pp1642-3)
Members of the class of compounds composed of AMINO ACIDS joined together by peptide bonds between adjacent amino acids into linear, branched or cyclical structures. OLIGOPEPTIDES are composed of approximately 2-12 amino acids. Polypeptides are composed of approximately 13 or more amino acids. PROTEINS are linear polypeptides that are normally synthesized on RIBOSOMES.
Classic quantitative assay for detection of antigen-antibody reactions using a radioactively labeled substance (radioligand) either directly or indirectly to measure the binding of the unlabeled substance to a specific antibody or other receptor system. Non-immunogenic substances (e.g., haptens) can be measured if coupled to larger carrier proteins (e.g., bovine gamma-globulin or human serum albumin) capable of inducing antibody formation.
Tumors or cancer of the URINARY BLADDER.
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
Mutant mice homozygous for the recessive gene "nude" which fail to develop a thymus. They are useful in tumor studies and studies on immune responses.
RNA present in neoplastic tissue.
In vivo methods of screening investigative anticancer drugs, biologic response modifiers or radiotherapies. Human tumor tissue or cells are transplanted into mice or rats followed by tumor treatment regimens. A variety of outcomes are monitored to assess antitumor effectiveness.
The genetic constitution of the individual, comprising the ALLELES present at each GENETIC LOCUS.
Short sequences (generally about 10 base pairs) of DNA that are complementary to sequences of messenger RNA and allow reverse transcriptases to start copying the adjacent sequences of mRNA. Primers are used extensively in genetic and molecular biology techniques.
A neoplasm composed entirely of GRANULOSA CELLS, occurring mostly in the OVARY. In the adult form, it may contain some THECA CELLS. This tumor often produces ESTRADIOL and INHIBIN. The excess estrogen exposure can lead to other malignancies in women and PRECOCIOUS PUBERTY in girls. In rare cases, granulosa cell tumors have been identified in the TESTES.
The treatment of a disease or condition by several different means simultaneously or sequentially. Chemoimmunotherapy, RADIOIMMUNOTHERAPY, chemoradiotherapy, cryochemotherapy, and SALVAGE THERAPY are seen most frequently, but their combinations with each other and surgery are also used.
A malignant ovarian neoplasm, thought to be derived from primordial germ cells of the sexually undifferentiated embryonic gonad. It is the counterpart of the classical seminoma of the testis, to which it is both grossly and histologically identical. Dysgerminomas comprise 16% of all germ cell tumors but are rare before the age of 10, although nearly 50% occur before the age of 20. They are generally considered of low-grade malignancy but may spread if the tumor extends through its capsule and involves lymph nodes or blood vessels. (Dorland, 27th ed; DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1646)
All tumors in the GASTROINTESTINAL TRACT arising from mesenchymal cells (MESODERM) except those of smooth muscle cells (LEIOMYOMA) or Schwann cells (SCHWANNOMA).
Linear POLYPEPTIDES that are synthesized on RIBOSOMES and may be further modified, crosslinked, cleaved, or assembled into complex proteins with several subunits. The specific sequence of AMINO ACIDS determines the shape the polypeptide will take, during PROTEIN FOLDING, and the function of the protein.
A positive regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins.
Proteins prepared by recombinant DNA technology.
Accumulation of a drug or chemical substance in various organs (including those not relevant to its pharmacologic or therapeutic action). This distribution depends on the blood flow or perfusion rate of the organ, the ability of the drug to penetrate organ membranes, tissue specificity, protein binding. The distribution is usually expressed as tissue to plasma ratios.
An imaging technique using compounds labelled with short-lived positron-emitting radionuclides (such as carbon-11, nitrogen-13, oxygen-15 and fluorine-18) to measure cell metabolism. It has been useful in study of soft tissues such as CANCER; CARDIOVASCULAR SYSTEM; and brain. SINGLE-PHOTON EMISSION-COMPUTED TOMOGRAPHY is closely related to positron emission tomography, but uses isotopes with longer half-lives and resolution is lower.
Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI.
The span of viability of a cell characterized by the capacity to perform certain functions such as metabolism, growth, reproduction, some form of responsiveness, and adaptability.
One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.
Ionized gases, consisting of free electrons and ionized atoms or molecules which collectively behave differently than gas, solid, or liquid. Plasma gases are used in biomedical fields in surface modification; biological decontamination; dentistry (e.g., PLASMA ARC DENTAL CURING LIGHTS); and in other treatments (e.g., ARGON PLASMA COAGULATION).
Laboratory mice that have been produced from a genetically manipulated EGG or EMBRYO, MAMMALIAN.
Tumors or cancer of the SKIN.
Endogenous substances, usually proteins, which are effective in the initiation, stimulation, or termination of the genetic transcription process.
A procedure consisting of a sequence of algebraic formulas and/or logical steps to calculate or determine a given task.
The use of two or more chemicals simultaneously or sequentially in the drug therapy of neoplasms. The drugs need not be in the same dosage form.
Mice homozygous for the mutant autosomal recessive gene "scid" which is located on the centromeric end of chromosome 16. These mice lack mature, functional lymphocytes and are thus highly susceptible to lethal opportunistic infections if not chronically treated with antibiotics. The lack of B- and T-cell immunity resembles severe combined immunodeficiency (SCID) syndrome in human infants. SCID mice are useful as animal models since they are receptive to implantation of a human immune system producing SCID-human (SCID-hu) hematochimeric mice.
Transport proteins that carry specific substances in the blood or across cell membranes.
A subclass of lipid-linked proteins that contain a GLYCOSYLPHOSPHATIDYLINOSITOL LINKAGE which holds them to the CELL MEMBRANE.
The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.
A method of measuring the effects of a biologically active substance using an intermediate in vivo or in vitro tissue or cell model under controlled conditions. It includes virulence studies in animal fetuses in utero, mouse convulsion bioassay of insulin, quantitation of tumor-initiator systems in mouse skin, calculation of potentiating effects of a hormonal factor in an isolated strip of contracting stomach muscle, etc.
Variant forms of the same gene, occupying the same locus on homologous CHROMOSOMES, and governing the variants in production of the same gene product.
Liquid chromatographic techniques which feature high inlet pressures, high sensitivity, and high speed.
Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)
A group of acidic proteins that are major components of SECRETORY GRANULES in the endocrine and neuroendocrine cells. They play important roles in the aggregation, packaging, sorting, and processing of secretory protein prior to secretion. They are cleaved to release biologically active peptides. There are various types of granins, usually classified by their sources.
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.
A technique using antibodies for identifying or quantifying a substance. Usually the substance being studied serves as antigen both in antibody production and in measurement of antibody by the test substance.
A benign epithelial tumor with a glandular organization.
Compounds that are used in medicine as sources of radiation for radiotherapy and for diagnostic purposes. They have numerous uses in research and industry. (Martindale, The Extra Pharmacopoeia, 30th ed, p1161)
Period after successful treatment in which there is no appearance of the symptoms or effects of the disease.
The co-inheritance of two or more non-allelic GENES due to their being located more or less closely on the same CHROMOSOME.
Proteins which bind to DNA. The family includes proteins which bind to both double- and single-stranded DNA and also includes specific DNA binding proteins in serum which can be used as markers for malignant diseases.
A negative regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins.
A true neoplasm composed of a number of different types of tissue, none of which is native to the area in which it occurs. It is composed of tissues that are derived from three germinal layers, the endoderm, mesoderm, and ectoderm. They are classified histologically as mature (benign) or immature (malignant). (From DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1642)
Complex pharmaceutical substances, preparations, or matter derived from organisms usually obtained by biological methods or assay.
A sarcoma derived from deep fibrous tissue, characterized by bundles of immature proliferating fibroblasts with variable collagen formation, which tends to invade locally and metastasize by the bloodstream. (Stedman, 25th ed)
Cytoplasmic proteins that bind estrogens and migrate to the nucleus where they regulate DNA transcription. Evaluation of the state of estrogen receptors in breast cancer patients has become clinically important.
Partial proteins formed by partial hydrolysis of complete proteins or generated through PROTEIN ENGINEERING techniques.
Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques.
The movement of cells from one location to another. Distinguish from CYTOKINESIS which is the process of dividing the CYTOPLASM of a cell.
A transplantable, poorly differentiated malignant tumor which appeared originally as a spontaneous breast carcinoma in a mouse. It grows in both solid and ascitic forms.
Experimental transplantation of neoplasms in laboratory animals for research purposes.
DNA sequences which are recognized (directly or indirectly) and bound by a DNA-dependent RNA polymerase during the initiation of transcription. Highly conserved sequences within the promoter include the Pribnow box in bacteria and the TATA BOX in eukaryotes.
Specific proteins found in or on cells of progesterone target tissues that specifically combine with progesterone. The cytosol progesterone-receptor complex then associates with the nucleic acids to initiate protein synthesis. There are two kinds of progesterone receptors, A and B. Both are induced by estrogen and have short half-lives.
An anaplastic, highly malignant, and usually bronchogenic carcinoma composed of small ovoid cells with scanty neoplasm. It is characterized by a dominant, deeply basophilic nucleus, and absent or indistinct nucleoli. (From Stedman, 25th ed; Holland et al., Cancer Medicine, 3d ed, p1286-7)
An enzyme that catalyzes the conversion of an orthophosphoric monoester and water to an alcohol and orthophosphate. EC
The compound is given by intravenous injection to do POSITRON-EMISSION TOMOGRAPHY for the assessment of cerebral and myocardial glucose metabolism in various physiological or pathological states including stroke and myocardial ischemia. It is also employed for the detection of malignant tumors including those of the brain, liver, and thyroid gland. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1162)
Addition of methyl groups to DNA. DNA methyltransferases (DNA methylases) perform this reaction using S-ADENOSYLMETHIONINE as the methyl group donor.
The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
An inorganic and water-soluble platinum complex. After undergoing hydrolysis, it reacts with DNA to produce both intra and interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity of cisplatin correlates with cellular arrest in the G2 phase of the cell cycle.
Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.
A nonparametric method of compiling LIFE TABLES or survival tables. It combines calculated probabilities of survival and estimates to allow for observations occurring beyond a measurement threshold, which are assumed to occur randomly. Time intervals are defined as ending each time an event occurs and are therefore unequal. (From Last, A Dictionary of Epidemiology, 1995)
Removal and pathologic examination of specimens in the form of small pieces of tissue from the living body.
A statistical technique that isolates and assesses the contributions of categorical independent variables to variation in the mean of a continuous dependent variable.
The regular and simultaneous occurrence in a single interbreeding population of two or more discontinuous genotypes. The concept includes differences in genotypes ranging in size from a single nucleotide site (POLYMORPHISM, SINGLE NUCLEOTIDE) to large nucleotide sequences visible at a chromosomal level.
A set of techniques used when variation in several variables has to be studied simultaneously. In statistics, multivariate analysis is interpreted as any analytic method that allows simultaneous study of two or more dependent variables.
Non-antibody proteins secreted by inflammatory leukocytes and some non-leukocytic cells, that act as intercellular mediators. They differ from classical hormones in that they are produced by a number of tissue or cell types rather than by specialized glands. They generally act locally in a paracrine or autocrine rather than endocrine manner.
A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm but is often wrongly used as a synonym for "cancer." (From Dorland, 27th ed)
The biosynthesis of RNA carried out on a template of DNA. The biosynthesis of DNA from an RNA template is called REVERSE TRANSCRIPTION.
Experimentally induced neoplasms of CONNECTIVE TISSUE in animals to provide a model for studying human SARCOMA.
A heterogeneous aggregate of at least three distinct histological types of lung cancer, including SQUAMOUS CELL CARCINOMA; ADENOCARCINOMA; and LARGE CELL CARCINOMA. They are dealt with collectively because of their shared treatment strategy.
A peptide hormone that lowers calcium concentration in the blood. In humans, it is released by thyroid cells and acts to decrease the formation and absorptive activity of osteoclasts. Its role in regulating plasma calcium is much greater in children and in certain diseases than in normal adults.
Single-stranded complementary DNA synthesized from an RNA template by the action of RNA-dependent DNA polymerase. cDNA (i.e., complementary DNA, not circular DNA, not C-DNA) is used in a variety of molecular cloning experiments as well as serving as a specific hybridization probe.
A heterogeneous group of sporadic or hereditary carcinoma derived from cells of the KIDNEYS. There are several subtypes including the clear cells, the papillary, the chromophobe, the collecting duct, the spindle cells (sarcomatoid), or mixed cell-type carcinoma.
Soft tissue tumors or cancer arising from the mucosal surfaces of the LIP; oral cavity; PHARYNX; LARYNX; and cervical esophagus. Other sites included are the NOSE and PARANASAL SINUSES; SALIVARY GLANDS; THYROID GLAND and PARATHYROID GLANDS; and MELANOMA and non-melanoma skin cancers of the head and neck. (from Holland et al., Cancer Medicine, 4th ed, p1651)
Biological synthesis[edit]. Hyaluronic acid is synthesized by a class of integral membrane proteins called hyaluronan synthases ... Hyaluronan's contribution to tumor growth may be due to its interaction with CD44. Receptor CD44 participates in cell adhesion ... It is unique among glycosaminoglycans in that it is nonsulfated, forms in the plasma membrane instead of the Golgi apparatus, ... Decrease in skin elasticity, impaired local inflammatory response, and impaired tissue repair were also observed.[18] Their ...
... innate immunity by raising defence against extracellular microbes and inhibiting the release of pro-inflammatory markers and ... The biological half-life of BNP, however, is twice as long as that of ANP, and that of NT-proBNP is even longer, making these ... Plasma concentrations of glycerol and nonesterified fatty acids are increased by i.v. infusion of ANP in humans. Activates ... These indications can be a marker of a large atrial myxoma. Opinions regarding the use of ANP for the treatment of acute heart ...
... tumor markers are produced either by the tumor itself or by the body in response to the presence of cancer or some inflammatory ... If a tumor marker level is higher than normal, the patient is examined more closely to look for cancer or other conditions. For ... Thus, the concentration of plasma microvesicles with molecular markers indicative of the disease state may be used as an ... and are likely involved in tumor progression. They offer a unique opportunity to noninvasively access the wealth of biological ...
... a protein network that enhances transcription of inflammatory markers and mediators that may cause insulin resistance. Second, ... High plasma levels of insulin and glucose due to insulin resistance are a major component of the metabolic syndrome. If insulin ... Koga M, Kasayama S (2010). "Clinical impact of glycated albumin as another glycemic control marker". Endocrine Journal. 57 (9 ... The elevated insulin levels also have additional effects (see insulin) that cause further abnormal biological effects ...
... so the immune system no longer attacks the tumor cells. Paradoxically, macrophages can promote tumor growth when tumor cells ... The plasticity of immune cells and the balance between pro-inflammatory and anti-inflammatory signals are crucial aspects of ... The immune system is a network of biological processes that protects an organism from diseases. It detects and responds to a ... ILCs do not express myeloid or dendritic cell markers. Natural killer cells (NK) are lymphocytes and a component of the innate ...
... and a decrease in anti-inflammatory markers, such as IL-10, that plays a role in tumor suppression. Chronic shift work has been ... an inflammatory marker of cardiovascular risk". Journal of the American College of Cardiology. 43 (4): 678-83. doi:10.1016/j. ... Acute sleep loss has been shown to increase the levels of t-tau in blood plasma, which may explain the neurocognitive effects ... Gene-transcription feedback loops in individual SCN cells form the molecular basis of biological timekeeping. Circadian phase ...
Markers of systemic inflammation, including C-reactive protein, are often increased, as are fibrinogen, interleukin 6, tumor ... defining it by the different sets of biological markers. The presence of metabolic syndrome is associated with a higher ... Quilon, Augusto; Brent, Lawrence (2010). "The primary care physician's guide to inflammatory arthritis: diagnosis". The Journal ... Fasting plasma glucose ≥ 6.1 mmol/L (110 mg/dl) There is confusion as to whether, in 2004, the American Heart Association and ...
... inflammatory markers, and metabolic syndrome in a middle-aged and elderly Chinese population". Diabetology & Metabolic Syndrome ... "The Journal of Biological Chemistry. 265 (3): 1454-8. PMID 2104842.. *^ Belkner, J; Stender, H; Kühn, H (1998). "The rabbit 15- ... are elevated in the plasma and erythrocytes of patients with Alzheimer's disease and in the plasma but not erythrocytes of ... and may have clinically relevance as a marker for[32][33] and potential contributor to[33] human disease. 13-Oxo-ODE itself may ...
... decreased plasma levels of the inflammatory cytokine tumour necrosis factor a (TNF-a), improved immune functions, and increased ... plasma or lymphocyte GSH concentrations and hepatitis virus markers in 25 patients with chronic hepatitis B or C. Immunocal (12 ... The Biological Activity Of Undenatured Dietary Whey Proteins: Role Of Glutathione Bounous G., Gold P. Clin Invest Mod. 1991 Aug ... Lymphocyte GSH was used as a marker of tissue GSH. There were no baseline differences (age, ht, wt, %ideal wt, peak power, 30-s ...
The CD38 protein is a marker of cell activation. It has been connected to HIV infection, leukemias, myelomas, solid tumors, ... Zambello R, Barilà G, Sabrina Manni S (2020). "NK cells and CD38: Implication for (Immuno)Therapy in Plasma Cell Dyscrasias". ... Oishi Y, Manabe I (2016). "Macrophages in age-related chronic inflammatory diseases". npj Aging and Mechanisms of Disease. 2: ... Quarona V, Zaccarello G, Chillemi A (2013). "CD38 and CD157: a long journey from activation markers to multifunctional ...
Wu H, Zhang Z, Hu X, Zhao R, Song Y, Ban X, Qi J, Wang J (June 2010). "Dynamic changes of inflammatory markers in brain after ... via a converging plasmin/stromelysin-1 cascade enhances tumor cell invasion". The Journal of Biological Chemistry. 274 (19): ... Zucker S, Lysik RM, DiMassimo BI, Zarrabi HM, Moll UM, Grimson R, Tickle SP, Docherty AJ (August 1995). "Plasma assay of ... a potentially useful laboratory marker". Clinical Immunology and Immunopathology. 78 (2): 161-71. doi:10.1006/clin.1996.0025. ...
Inflammatory lung diseases are characterized by expression of specific inflammatory genes such as NF-κB and AP-1 transcription ... HDAC3 has even been found to interact with the plasma membrane. Silencing Mediator for Retinoic Acid and Thyroid Hormone (SMRT ... HDACs expression and activity in tumor cells is very different from normal cells. The overexpression and increased activity of ... Acetylated histones, the octomeric protein cores of nucleosomes, represent a type of epigenetic marker within chromatin. ...
Markers of T cell activation include CD69, CD71 and CD25 (also a marker for Treg cells), and HLA-DR (a marker of human T cell ... "The Journal of Biological Chemistry. 290 (51): 30204-11. doi:10.1074/jbc.R115.685990. PMC 4683245. PMID 26468291.. ... Cytotoxic T cells (TC cells, CTLs, T-killer cells, killer T cells) destroy virus-infected cells and tumor cells, and are also ... T helper cells (TH cells) assist other white blood cells in immunologic processes, including maturation of B cells into plasma ...
EBV is associated only with the inflammatory form of FDCS. In these cases, the FD cells express FD-cell markers (e.g. CD21, ... These Reed-Sternberg-like cells are EBV+ B cells that express the tumor marker cell surface membrane protein, CD30, the B cell ... Although derived from B cells, these cells express plasma cell rather than B cell markers. The role of EBV in the development ... Series B, Biological Sciences. 372 (1732): 20160271. doi:10.1098/rstb.2016.0271. PMC 5597738. PMID 28893938. Li S, Young KH, ...
The NK-92 cell line does not express KIR and is developed for tumor therapy.[9][10][11][12] ... The motor arc of the inflammatory reflex is termed the cholinergic anti-inflammatory pathway. ... form holes in the plasma membrane of the pathogen, resulting in cytolysis of the pathogen cell, causing the death of the ... Anatomical barriers include physical, chemical and biological barriers. The epithelial surfaces form a physical barrier that is ...
GGT is expressed in high levels in many different tumors. It is known to accelerate tumor growth and to increase resistance to ... Indeed, the two markers correlate well, though there are conflicting data about whether GGT has better sensitivity. In general ... GGT is predominantly used as a diagnostic marker for liver disease. Latent elevations in GGT are typically seen in patients ... Rosalki SB, Tarlow D, Rau D (August 1971). "Plasma gamma-glutamyl transpeptidase elevation in patients receiving enzyme- ...
Major sites of cleavage by cathepsins B, D, and L". The Journal of Biological Chemistry. 266 (30): 20198-204. PMID 1939080.. ... This protease has been regarded an independent marker of poor prognosis in breast cancer being correlated with the incidence of ... Over-expression of cathepsin D stimulates tumorigenicity and metastasis as well as initiation of tumor apoptosis. ... macrophage inflammatory protein-1 beta, and SLC that are expressed in human breast cancer". The American Journal of Pathology. ...
Markers of T cell activation include CD69, CD71 and CD25 (also a marker for Treg cells), and HLA-DR (a marker of human T cell ... "The Journal of Biological Chemistry. 290 (51): 30204-11. doi:10.1074/jbc.R115.685990. PMC 4683245. PMID 26468291.. ... T helper cells (TH cells) assist other lymphocytes, including maturation of B cells into plasma cells and memory B cells, and ... Cytotoxic T cells (TC cells, CTLs, T-killer cells, killer T cells) destroy virus-infected cells and tumor cells, and are also ...
However, no distinct surface or biochemical markers of necrotic cell death have been identified yet, and only negative markers ... "Connection Map for Tumor Necrosis Factor Pathway". Science STKE. 2007: tw132. doi:10.1126/stke.3822007tw132.. ... In addition to its importance as a biological phenomenon, defective apoptotic processes have been implicated in a wide variety ... Inhibition of apoptosis can result in a number of cancers, autoimmune diseases, inflammatory diseases, and viral infections. It ...
Jump to navigation Jump to search Cancer of plasma cells. .mw-parser-output .hatnote{font-style:italic}.mw-parser-output div. ... Related conditions include solitary plasmacytoma (a single tumor of plasma cells, typically treated with irradiation), plasma ... Roberts, DL; Dive, C; Renehan, AG (2010). "Biological mechanisms linking obesity and cancer risk: new perspectives". Annual ... or a chronic inflammatory condition such as rheumatoid arthritis.[28] EBV-positive multiple myeloma is classified by the World ...
protein localization to plasma membrane. • inflammatory response. • regulation of small GTPase mediated signal transduction. • ... Rac1-dependent pathway inhibition resulted in the reversal of tumor cell phenotypes, suggesting Rac1 as a predictive marker and ... Jump to navigation Jump to search "Rac1" redirects here. For the first game in the Ratchet & Clank series, see Ratchet & Clank. ... Biological process. • positive regulation of Rho protein signal transduction. • regulation of respiratory burst. • movement of ...
"The Journal of Biological Chemistry. 285 (21): 16087-16095. doi:10.1074/jbc.M110.110130. PMC 2871477. PMID 20308063.. ... "Soft tissue tumors: Pericytoma with t(7;12)". Atlas of Genetics and Cytogenetics in Oncology and Haematology. University ... Molecular markers of protein deficits". Journal of Applied Physiology. 95 (2): 791-802. doi:10.1152/japplphysiol.01113.2002. ... In deformation, one end of myosin is bound to the plasma membrane, while the other end "walks" toward the plus end of the actin ...
Jump to navigation Jump to search Programmed cell death in multicellular organisms ... Series B, Biological Sciences. 372 (1726): 20160218. doi:10.1098/rstb.2016.0218. PMC 5483520. PMID 28630157.. ... The tumor-suppressor protein p53 accumulates when DNA is damaged due to a chain of biochemical factors. Part of this pathway ... After the shrinking, the plasma membrane blebs and folds around different organelles. The blebs continue to form and the ...
Jump to navigation Jump to search For other uses, see Ageing (disambiguation). ... Series A, Biological Sciences and Medical Sciences. 56 (3): M146-56. CiteSeerX doi:10.1093/gerona/56.3.m146. ... "Telomere Shortening and Tumor Formation by Mouse Cells Lacking Telomerase RNA". Cell. 91 (1): 25-34. doi:10.1016/S0092-8674(01) ... Inflammatory Factors, and Mitochondrial Complexes in Arctica islandica, the Longest-Living Noncolonial Animal". J Gerontol A ...
This decreased NGF may serve as a biological marker when assessing a person's present bipolar disorder state.[43] When treated ... NGF is abundant in seminal plasma. Recent studies have found that it induces ovulation in some mammals.[23] Nerve Growth ... Survival occurs when recruited cytoplasmic adaptor proteins facilitate signal transduction through tumor necrosis factor ... The expression of NGF is increased in inflammatory diseases where it suppresses inflammation.[27] NGF appears to promote myelin ...
However, no distinct surface or biochemical markers of necrotic cell death have been identified yet, and only negative markers ... Series B, Biological Sciences. 372 (1726): 20160218. doi:10.1098/rstb.2016.0218. PMC 5483520. PMID 28630157.. ... The tumor-suppressor protein p53 accumulates when DNA is damaged due to a chain of biochemical factors. Part of this pathway ... After the shrinking, the plasma membrane blebs and folds around different organelles. The blebs continue to form and the ...
Research indicates various markers that can be used for DNA methylation.Deciding which marker to use for an assay is one of the ... Series B, Biological Sciences. 368 (1609): 20110330. doi:10.1098/rstb.2011.0330. PMC 3539359. PMID 23166394.. ... Since many tumor suppressor genes are silenced by DNA methylation during carcinogenesis, there have been attempts to re-express ... High plasma levels of homocysteine inhibit DNA methyltransferases, which causes hypomethylation. Hypomethylation of DNA affects ...
"Relationship of plasma polyunsaturated fatty acids to circulating inflammatory markers". The Journal of Clinical Endocrinology ... acid levels are actually associated with reduced pro-inflammatory IL-6 and IL-1 levels and increased anti-inflammatory tumor ... Wlodawer, P; Samuelsson, B (1973). "On the organization and mechanism of prostaglandin synthetase". The Journal of Biological ... One study at Baylor University reported a significant reduction in resting inflammation (via marker IL-6) in young men ...
plasma membrane. • integral component of plasma membrane. • extracellular exosome. • membrane. • focal adhesion. • ... Several treatments reduce CD97 expression in tumor cells such as cytokine tumor growth factor (TGF)β as well as the compounds ... Biological process. • cell-cell signaling. • G-protein coupled receptor signaling pathway. • cell surface receptor signaling ... inflammatory response. • immune response. • signal transduction. • neutrophil degranulation. • adenylate cyclase-activating G- ...
The specific microRNA, miR-506 has been found to work as a tumor antagonist in several studies. A significant number of ... TIMP3 also decreases the expression of TNFα (a pro-inflammatory regulator) during turbulent flow. Activity of TNFα in turbulent ... This makes them a valuable phylogenetic marker, and they are being looked upon as a possible solution to outstanding ... MiRNAs influence B cell maturation, generation of pre-, marginal zone, follicular, B1, plasma and memory B cells. Another role ...
SeV can stimulate the production of macrophage inflammatory protein-1α (MIB-1α) and -β (MIB-1β), RANTES (CCL5), tumor necrosis ... Irie T, Nagata N, Yoshida T, Sakaguchi T (February 2008). "Recruitment of Alix/AIP1 to the plasma membrane by Sendai virus C ... Most important observation is that SeV infection triggers DC maturation, which is manifested in DC cell surface markers ... Series B, Physical and Biological Sciences. 85 (8): 348-62. Bibcode:2009PJAB...85..348F. doi:10.2183/pjab.85.348. PMC 3621571. ...
... inflammatory markers, and metabolic syndrome in a middle-aged and elderly Chinese population". Diabetology & Metabolic Syndrome ... are elevated in the plasma and erythrocytes of patients with Alzheimer's disease and in the plasma but not erythrocytes of ... Since this conjugate may be rapidly exported from the cell and has not yet been characterized for biological activity, it is ... Kelavkar, U. P; Hutzley, J; McHugh, K; Allen, K. G; Parwani, A (2009). "Prostate tumor growth can be modulated by dietarily ...
... substitution therapy with testosterone results in a significant reduction of inflammatory markers. These effects are mediated ... The plasma protein binding of testosterone is 98.0 to 98.5%, with 1.5 to 2.0% free or unbound. It is bound 65% to sex hormone- ... Liu J, Portnoy J, Raine A (August 2012). "Association between a marker for prenatal testosterone exposure and externalizing ... Greatly differing amounts of testosterone prenatally, at puberty, and throughout life account for a share of biological ...
It is an early activation marker that is expressed in hematopoietic stem cells, T cells, and many other cell types in the ... "Activation markers of human basophils: CD69 expression is strongly and preferentially induced by IL-3". The Journal of Allergy ... The Journal of Biological Chemistry. 270 (37): 21545-51. doi:10.1074/jbc.270.37.21545. PMID 7665567. Bezouska K, Nepovím A, ... "T Follicular Helper Cell-Germinal Center B Cell Interaction Strength Regulates Entry into Plasma Cell or Recycling Germinal ...
"Inflammatory markers and onset of cardiovascular events: results from the Health ABC study". Circulation. 108 (19): 2317-2322. ... The biological basis for anxiety disorders is rooted in the consistent activation of the stress response. Fear, which is the ... a marker of IL-6, in adulthood. There is extensive evidence that the above physiological systems affect one another's ... "Plasma concentration of interleukin-6 and the risk of future myocardial infarction among apparently healthy men". Circulation. ...
This classic biological idea has however been perturbed recently by the discovery that the bacterium E. coli may split into ... Blasco MA, Lee HW, Hande MP, Samper E, Lansdorp PM, DePinho RA, Greider CW (October 1997). "Telomere shortening and tumor ... June 2008). "Effect of 6-month calorie restriction and exercise on serum and liver lipids and markers of liver function". ... Moderate levels of exercise have been correlated with preventing ageing and improving quality of life by reducing inflammatory ...
It is a monoclonal antibody that blocks the biological action of TNF-α (tumor necrosis factor-alpha). TNF-α is an inflammatory ... For the follow-up of PDP disease activity, bone formation markers such as TAP, BAP, BGP, carbodyterminal propeptide of type I ... 1992). "Circulating plasma levels of platelet-derived growth factor in patients with hypertrophic osteoarthropathy". Clin Exp ... Von Willebrand factor is a marker of platelet and endothelial activation. This suggests that the activation of endothelial ...
... make EBV-DNA a meaningful marker for the biological and clinical presentation of EBV-associated HL. Since plasma EBV-DNA may be ... Detection and quantification of mutations in the plasma of patients with colorectal tumors. Proc Natl Acad Sci U S A 2005;102: ... EBV may modulate the cellular composition of the microenvironment and the production of inflammatory cytokines of prognostic ... Conclusion: Although the presence of EBV-DNA in peripheral blood cannot be regarded as a surrogate marker for EBER, the plasma ...
CONCLUSIONS-The associations of sleep duration and snoring with lipid profile, hormone measures, and/or inflammatory markers ... It is the primary marker of protein formation in response to inflammatory stimuli and has been shown to predict stroke and ... Plasma CRP was measured using a U.S. CRP enzyme-linked immunosorbent assay kit (Diagnostic Systems Laboratories, Webster, TX) ... The biological mechanisms underlying the relationship between sleep and cardiovascular-related conditions remain to be fully ...
Rai AJ, Zhang Z, Rosenzweig J, Shih I, Pham T, Fung ET, Sokoll LJ, Chan DW (2002) Proteomic approaches to tumor marker ... Indeed, multi‐marker combinations may achieve higher specificity and sensitivity compared to single markers and first tools for ... has become a powerful technology in biological research and it is now poised to allow the characterization of the plasma ... Examples of test for different classes of analytes are as follows: Proteins and enzymes-liver enzymes, inflammatory proteins, ...
Vascular risk factors and markers of endothelial function as determinants of inflammatory markers in type 1 diabetes: the ... Indeed, the expression of hs-CRP as a marker of inflammatory activity is very complex and cannot only be explained by the ... Plasma hs-CRP was correlated with triglycerides and triglyceride-to-HDL ratio, suggesting that strategies to decrease ... Despite these plausible biological explanations, the association between lipid variables and CRP is not completely established ...
inflammatory marker (orosomucoid, tumour necrosis factor-alpha, transforming growth factor-beta, vascular endothelial growth ... and may be regulated by inflammatory mediators as observed in hepatocytes. The biological function of AGP remains unknown; ... plasma level can rise from about 0.8 to 3 g/L within 24 h following the unset of an acute-phase response *acute phase proteins ... Jump to:navigation, search. Contents. *1 Alpha-1-acidic glycoprotein *1.1 Functions ...
inflammatory marker (orosomucoid, tumour necrosis factor-alpha, transforming growth factor-beta, vascular endothelial growth ... Alpha-1 acid glycoprotein (AGP) is a highly glycosylated, negatively charged plasma protein suggested to have anti-inflammatory ... and may be regulated by inflammatory mediators as observed in hepatocytes. The biological function of AGP remains unknown; ... Jump to:navigation, search. Contents. *1 Alpha-1-acidic glycoprotein *1.1 Functions ...
Because all three potential markers performed well in the comparison of primary PDAC and CCC tumors, they were also tested in ... ANXA1 e.g. was often strongly detectable in stromal or inflammatory cells, also in CCC tissue, but not in tumorous ... Considering the panel to be positive for PDAC if at least one marker classifies the samples as PDAC (applying above mentioned ... Taking the general biological variance into consideration, these results are very similar to ours. Concerning the ...
Premature atherothrombosis-related nutritional markers: Homocysteine in plasma. Independent risk marker: Microalbuminuria ... Inflammatory biomarkers: Ultrasensitive C-reactive protein and Fibrinogen. ... Tumor markers. Colorectal and other digestive neoplasia, Breast, Lung Differentiation, Prostate, Liver, Pancreas… ... Biomedical screening of CSF and other biological fluids. *Urine tests (systematic and 24-hour tests) ...
... accumulates in the plasma membrane of nerve terminals at NMJs and regulates exocytosis at peripheral and central synapses. ... The aim of this review is to suggest innovative and promising sarcopenia markers investigating the link between skeletal muscle ... accumulates in the plasma membrane of nerve terminals at NMJs and regulates exocytosis at peripheral and central synapses. ... The aim of this review is to suggest innovative and promising sarcopenia markers investigating the link between skeletal muscle ...
... manifested by inflammatory infiltration in the tumor is considered to influence the biological behavior of tumors. Also, a ... The aim of the present study is to analyze tumor-associated tissue eosinophilia (TATE) and to compare TATE density in the ... Besides the phenotypic properties of the tumor parenchymal cells, possible signs in regard to recurrence could also be derived ... initial foci of age and gender-matched 156 cases of recurrent and non-recurrent bladder cancers; the tumors that have relapsed ...
Here we discuss the up-to-date concepts of definition and classification, theoretical views on tumour origin along with ... Radical surgical resection with tumour-free margins is the mainstay of treatment. Adequate treatment approach can be very ... including detection of tumour markers, viscosity [72], mucinous differentiation [73], KRAS testing, proteome analysis [74] in ... Tumour-associated glycoprotein (TAG) 72 has been suggested as a highly informative marker for differential diagnosis between ...
Having been traditionally utilized as a marker of infection and cardiovascular events, there is now growing evidence that CRP ... In terms of pro-inflammatory cytokine production, mCRP increases interleukin-8 and monocyte chemoattractant protein-1 ... particularly interleukin-6 and tumor necrosis factor-α. Unlike more recent publications, the findings of early work on CRP can ... there is mounting evidence that CRP isoforms have distinct biological properties, with nCRP often exhibiting more anti- ...
... direct accessibility of lung carcinomas has led to efforts to identify tumor-associated soluble markers in serum or plasma. ... For many years scientists have searched for a lung cancer-specific tumor marker that could be detected in peripheral blood. ... For early detection of lung cancer, we need more clinical data evaluating these new molecular biological markers from multiple ... B, WLB shows inflammatory changes in the bronchial mucosa but no suspicion of malignancy (left). LIFE bronchoscopy shows ...
... obesity is also related to increased levels of inflammatory markers, which are also putative risk factors for prostate cancer ( ... 6). The biological significance of these observations is not clear. Obviously, the relationship between serum testosterone and ... The Complex Relationship of Serum Testosterone with Age, Tumor Grade, and Obesity. Aside from how well intraprostatic hormone ... For example, signal transduction at the plasma membrane allows certain steroid hormones to act without entering the cell by ...
We also measured plasma levels of reactive C-protein and interleukin-6 (IL-6) as nonspecific markers of inflammation, and tumor ... microvascular dysfunction appears to involve Th2 inflammatory response. Of the biomarkers studied, plasma vWF:Ag was ... Brazilian Journal of Medical and Biological Research. On-line version ISSN 1414-431X. Braz J Med Biol Res vol.44 no.12 Ribeirão ... von Willebrand factor antigen is an independent marker of poor outcome in patients with early acute lung injury. Crit Care Med ...
Biological synthesis[edit]. Hyaluronic acid is synthesized by a class of integral membrane proteins called hyaluronan synthases ... Hyaluronans contribution to tumor growth may be due to its interaction with CD44. Receptor CD44 participates in cell adhesion ... It is unique among glycosaminoglycans in that it is nonsulfated, forms in the plasma membrane instead of the Golgi apparatus, ... Decrease in skin elasticity, impaired local inflammatory response, and impaired tissue repair were also observed.[18] Their ...
We have arrived at this conclusion by analyzing the expression by tumor 41 of the epithelial-specific marker 14-3-3σ (71), a ... Moll, R. (1998) Cytokeratins as markers of differentiation in the diagnosis of epithelial tumors. Subcell Biochem. 31, 205- 262 ... We have reported the isolation of a novel biological fluid, the interstitial fluid that perfuses the tumor microenvironment of ... 2 and 3, as well as presence in the plasma/serum (50-52) and NAF proteomes (35). Several of the proteins identified by 2D gel/ ...
JoVE publishes peer-reviewed scientific video protocols to accelerate biological, medical, chemical and physical research. ... BACKGROUND: Several studies seek biological markers that give diagnostic and degree of tumor development. The aim of this study ... Plasma was subjected to centrifugation. RESULTS: There was a big difference between the first and the second value obtained by ... The aim of the present study was to assess FibroTest (FT), a validated non-invasive marker of fibrosis in treatment-naive ...
The ASGCT presentation shows that genetic markers of Genentas Temferon were detectable in tumor specimens from all four ... Inflammatory factors expression was detected by ELISA and RT-qPCR, respectively. Our results showed that BMSCs could be induced ... Multiple myeloma is a cancer of the plasma cells, which are a type of white blood cell. Over time, myeloma cells multiply and ... Investigators observed CAR-positive cells at day 4 and M protein, which is a surrogate marker for multiple myeloma in mice and ...
Chogtu, B., Bairy, K. L., Satyam, S. M., Pirasanthan, R. & Gupta, S., 2013, In: Research Journal of Pharmaceutical, Biological ... Analgesic and anti-inflammatory activities of the essential oil from Cymbopogon flexuosus. Chandrashekar, K. S. & Prasanna, K. ... Analysis of factors influencing dry sliding wear behaviour of laser remelted plasma sprayed mo coating using response surface ... Analysis of 50 cases of solid pseudopapillary tumor of pancreas: Aggressive surgical resection provides excellent outcomes. ...
Local regions of hypoxia are created within a tumor, or within a region containing a tumor, resulting in enhanced activation of ... The methods include the use of compositions comprising platelet enriched plasma, for example, platelet rich plasma and/or ... METHOD FOR THE TREATMENT OF INFLAMMATORY DISORDERS - A method for the treatment of inflammatory disorders is disclosed, ... biological recognition, or biological mechanism of action. The system in accordance with an embodiment of the intention is a ...
Serum levels of the inflammatory markers sTNFR1 and sTNFR2, (soluble receptors of the tumor necrosis factor) were found to be ... The use of biological markers in medicine has come a long way with advances in the fields of pathology, biochemistry and most ... Of importance the marker should signify the disease early in its course, as there is evidence that delays in diagnosis and ... 24] report that the ratio of Aβ1-38/Aβ1-40 peptides in the plasma of patients with dementia may be a potential diagnostic tool ...
7.2.5. sFLCs and intact immunoglobulins are independent tumour markers. 7.2.6. Biological variation ... Model assumes either 100% (immediate) tumour killing (1) or 10% per day (2). The effect of 6 x 3.5 litre plasma exchanges over ... CSF FLCs as a marker of intrathecal immunoglobulin synthesis. 36.3. Prognostic significance of CSF FLCs ... FLCs as bioactive molecules in inflammatory diseases. 35.10. General population studies. 35.11. Conclusions ...
... tumor necrosis factor) and decreased levels of another inflammatory marker, calprotectin. Dr. Yui has reported anti- ... a marker of kidney damage; (3) Serum AST and ALT, markers of liver damage; (4) Thymic apoptosis, a marker for loss of immunity ... On the other hand, if enzyme levels are increased (this is called "induction"), blood plasma levels of a drug might decrease to ... The effects of oxidative stress are like a type of "biological rust." It has widespread effects in the aging process including ...
42] demonstrated that metformin-mediated repression of chronic inflammatory responses was associated with inhibition of tumor ... Overall, the biological effect of metformin on cancer cells is based on its ability to activate AMPK or inhibit downstream ... Inhibition of lung tumorigenesis by metformin is associated with decreased plasma igf-i and diminished receptor tyrosine kinase ... metformin down-regulates CSC marker genes in pancreatic cancer [123, 124], esophageal cancer [125], and breast cancer [126]. In ...
... expression of the activation marker CD25 and the trafficking marker CXCR4 and very low-level expression of the checkpoint ... The Centers for Disease Control and Prevention (CDC) has found that race and ethnicity are risk markers for other conditions ... This ensures that each stem and blood cell reflects a healthy tissue state uninfluenced by biological disease programs. ... tumors 3.3.4 Market challenge analysis Operational challenges associated with cell therapy development & usage ...
Protein glycosylation as a diagnostic and prognostic marker of chronic inflammatory gastrointestinal and liver diseases. ... Then, the sample (i.e., plasma) is added and SOMAmer-plasma protein complexes are formed. Unbound proteins are washed away, and ... Figure adapted from Rohloff et al.[21]; B: in SERS label-free technology, the biological sample is loaded on the SERS surface ( ... Furthermore, serological markers have been combined in several diagnostic algorithms [Figure 1]. For example, the predictive ...
... expression was found in pancreatic CTCs and correlated with EMT markers The ECM marker, was high in all isolated CTCs and ... Non-steroidal anti-inflammatory drug (NSAID)-activated gene-1 (NAG-1), also termed growth differentiation factor-15 (GDF15) or ... With this context, C3orf29 we decided to work on several biological models of hepatic steatosis in order to get strong support ... Detection of Early Apoptosis Induced by TPHE Using Annexin-V-FITC Labeling The perturbation in the plasma membrane asymmetry ...
Cabanlit M, Wills S, Goines P, Ashwood P, Van de Water J (2007) Brain-specific autoantibodies in the plasma of subjects with ... Wu WS and McClain KL (1997) DNA polymorphisms and mutations of the tumor necrosis factor-alpha (TNF-alpha) promoter in ... Mostafa GA and Kitchener N (2009) Serum anti-nuclear antibodies as a marker of autoimmunity in Egyptian autistic children. ... Table 6. Top 10 general biological processes found from functional enrichment within the Streptococcal gene network using ...
The plasma cells can also form a mass in the bone marrow or soft tissue. When one tumor is present, it is called a plasmacytoma ... Its concentration is not influenced by infections, liver diseases, or inflammatory diseases and used as a marker of glomerular ... Aim: The aim of the study was to formulate a standard operating protocol for immunohistochemical epithelial markers, CK, and ... biological, or developmental processes underlying mental functioning. Psychiatric cases are still as idiopathic, but in recent ...
Aim: The aim of the study was to investigate the effect of shock wave therapy on inflammatory markers in diabetic and non- ... Minor salivary gland tumors comprise 10-15% of salivary gland neoplasms. They represent ,1% of all tumors and 3-5% of head-and- ... Platelet-rich plasma, plasma-rich GF is the first generation, platelet-rich fibrin, and concentrated GF are the second ... Title: Xerostomia and dental caries - A marker for underlying autoimmune disorder. Category: Pharmacology. Section: Case ...
Moreover, our results are also enriched for tumor markers which are predictive of clinical features like tumor stage and we ... need of a non-invasive test.A total of 28 inflammatory and non-inflammatory plasma biomarkers were measured in 353 EDTA plasma ... Recurrent Copy Number Alterations in BRCA1-Mutated Ovarian Tumors Alter Biological Pathways HUMAN MUTATION Leunen, K., Gevaert ... A gene signature of secreted genes upregulated in CAFs was an independent marker of poor survival in patients with NSCLC. This ...
Biological Markers That Could Guide Treatment for Prostate Cancer Friday, December 14, 2018 ... Cancer Scientists Aim to Use Protein Power to Stop Tumor Growth. Apr. 7, 2020 Scientists have created a new therapy option that ... These patients were also tested for plasma levels of docosahexaenoic acid ... Driver Found for More Deadly Prostate Cancer. Nov ... New Genetic Compound Marker Could Help Early Diagnosis of Aggressive Prostate Cancer ...
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Blood inflammatory markers and fecal calprotectin levels were measured at the time of infusions.. Results: During the study ... Long-term deep remission during maintenance therapy with biological agents in inflammatory bowel diseases.. Authors:. Pauliina ... Infliximab [IFX], a tumour necrosis factor [TNF]-alpha blocker, is used to treat IBD patients successfully, though one-third of ... At last follow-up, 3.3 (0.6-8.0) years postoperatively, median plasma bilirubin was 6 (4-16) µmol/l, while liver biopsy showed ...
that assessed the health of 666 adults of both high and low socioeconomic status, by looking at inflammatory markers such as ... By expressing this gene, the ATF3 tricks the immune system into giving cancer a way out from a tumor to other parts of the body ... When facing less stress, the pressure marker, IL-6 will express less. IL-6 have some regulation effect to CRP, so in these ... Apparently the hormones secreted in a childs saliva may be a biological indicator of the trauma that kids undergo during ...
Latimer Awarded Komen Breast Cancer Research Grant Molecular Marker Identifies Normal Stem Cells as Intestinal Tumor Source New ... to Organ Rejection Squishy Hydrogels May Be the Ticket for Studying Biological Effects of Nanoparticles Alzheimers Markers ... Cells in Tumors Slows Growth, Researchers Show Largest Gene Study of Childhood Inflammatory Bowel Disease Identifies Five New ... Neural Stem Cells Are the Key Platelet-Rich Plasma Does Not Promote Stem Cell-Mediated Cartilage Repair Integrated Sensor Could ...
Latimer Awarded Komen Breast Cancer Research Grant Molecular Marker Identifies Normal Stem Cells as Intestinal Tumor Source New ... to Organ Rejection Squishy Hydrogels May Be the Ticket for Studying Biological Effects of Nanoparticles Alzheimers Markers ... Cells in Tumors Slows Growth, Researchers Show Largest Gene Study of Childhood Inflammatory Bowel Disease Identifies Five New ... Neural Stem Cells Are the Key Platelet-Rich Plasma Does Not Promote Stem Cell-Mediated Cartilage Repair Integrated Sensor Could ...
Latimer Awarded Komen Breast Cancer Research Grant Molecular Marker Identifies Normal Stem Cells as Intestinal Tumor Source New ... to Organ Rejection Squishy Hydrogels May Be the Ticket for Studying Biological Effects of Nanoparticles Alzheimers Markers ... Cells in Tumors Slows Growth, Researchers Show Largest Gene Study of Childhood Inflammatory Bowel Disease Identifies Five New ... Neural Stem Cells Are the Key Platelet-Rich Plasma Does Not Promote Stem Cell-Mediated Cartilage Repair Integrated Sensor Could ...
Latimer Awarded Komen Breast Cancer Research Grant Molecular Marker Identifies Normal Stem Cells as Intestinal Tumor Source New ... to Organ Rejection Squishy Hydrogels May Be the Ticket for Studying Biological Effects of Nanoparticles Alzheimers Markers ... Cells in Tumors Slows Growth, Researchers Show Largest Gene Study of Childhood Inflammatory Bowel Disease Identifies Five New ... Neural Stem Cells Are the Key Platelet-Rich Plasma Does Not Promote Stem Cell-Mediated Cartilage Repair Integrated Sensor Could ...
... melanoma tumour and cytogenicity. (Agrawal & Beohar 2010). Bromelain - We describe its anti-proliferative, anti-inflammatory ... VEGF, bFGF, and IL-8 - Our data suggest that the angiogenic serum factors VEGF, bFGF, and IL-8 are useful predictive markers ... and such biological activity correlates with a shift to phosphorylation of AKT2 isoform and E-cadherin down-regulation. Thus, ... Measurement of MMP-9 levels in serum has been reported as artificially high compared with the results obtained from plasma ...
Mans Spinal Cord Injury Genes Activated in Metastasis Also Drive the First Stages of Tumor Growth Microanalysis of Biological ... Hand Occurs Thanks to a Genetic Switch New Gene for Familial High Cholesterol Blood Marker Determines Who Will Respond to ... Stronger Imitating Monkeys Jumping Genes Could Lead To New Treatments for HIV Human Clinical Trials of Stem Cell Treatment That ... Drug Delivery Stem Cell Transplant Repairs Damaged Gut of Inflammatory Bowel Disease Stem Cells Converted to Living Intestinal ...
Only markers with at least one significant correlation are included. For the correlation, the measured marker values/ ... Circulating tumour cells (CTCs) are tumour cells that can enter the circulatory system, and are principally responsible for the ... correlation between module eigenlipids and plasma markers. The Pearson correlation coefficients are color-coded and ... In conclusion, OCB are prevalent in most MS patients and reflect the chronic inflammatory nature of the disease. We recommend ...
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This gBK marker should consequently be considered tumor-associated instead of becoming classified like a novel tumor-specific ... In this study we show that in polarized T cells the primary viral structural protein Gag accumulates to the plasma membrane of ... 2007) found out discrete jumps in grid level when traveling electrodes from dorsal-to-ventral suggesting large discrete modules ... Furthermore for resveratrol antioxidant [50 51 anti-inflammatory [52] neuroprotective [53] antiproliferative [54 55 and ...
  • The strong correlations of circulating EBV-DNA to parameters of disease activity, such as stage, the international prognostic score, and new biomarkers, as cell-free circulating DNA and the number of tumor-infiltrating CD68+ macrophages, make EBV-DNA a meaningful marker for the biological and clinical presentation of EBV-associated HL. (
  • However, the biological mechanisms underlying these associations have yet to be fully elucidated, and only a limited number of studies have examined the relationship between sleep habits and established biomarkers of cardiovascular disease (CVD) ( 8 , 21 - 24 ). (
  • Thus, we obtained information on sleep duration and frequency of snoring and measured plasma concentrations of biomarkers of CVD. (
  • The detection of biomarkers with high specificity and sensitivity for the differentiation of these tumor types would therefore be a valuable tool. (
  • Of the biomarkers studied, plasma vWF:Ag was independently associated with survival. (
  • Proteomics-based analysis of traditional sources of biomarkers, such as serum, plasma, or tissue lyzates, has resulted in a wealth of information and the finding of several potential tumor biomarkers. (
  • Here we present a novel and highly promising source of biomarkers, the tumor interstitial fluid (TIF) that perfuses the breast tumor microenvironment. (
  • Therefore the search for blood-based tumor biomarkers for early detection of lung cancer is particularly acute in Kazakhstan. (
  • Several publications describe the influence of anesthetic drugs and methods on tumor biology and alterations of biomarkers. (
  • In conclusion, vitamin B 6 may protect against colorectal cancer independent of other one-carbon metabolites and inflammatory biomarkers. (
  • Therefore, more sensitive biomarkers that overcome the limitations of circulating inflammatory markers are needed to characterize inflammation-associated depressive states. (
  • glucocorticoids and a cytokine network involving mainly interleukin-1 beta (IL-1 beta), tumour necrosis factor-alpha (TNF alpha), interleukin-6 and IL-6 related cytokines. (
  • Expression of the AGP gene is controlled by a combination of the major regulatory mediators, i.e. glucocorticoids and a cytokine network involving mainly interleukin-1 beta (IL-1 beta), tumour necrosis factor-alpha (TNF alpha), interleukin-6 and IL-6 related cytokines. (
  • Plasma levels of von Willebrand factor antigen (VWF:Ag), tissue plasminogen activator (t-PA) and its inhibitor (PAI-1), P-selectin, reactive C-protein, tumor necrosis factor alpha, and interleukin-6 and -10 were measured at baseline, and at 30, 90, and 180 days in all subjects. (
  • We also measured plasma levels of reactive C-protein and interleukin-6 (IL-6) as nonspecific markers of inflammation, and tumor necrosis factor alpha (TNF-α) and IL-10 as markers of Th1 and Th2 cytokine response, respectively. (
  • The levels of hepcidin, interleukin 6 (IL-6), tumor necrosis factor alpha (TNF-alpha), ferritin, iron, uric acid, and myoglobin were determined, as well as the total iron-binding capacity, unbound iron-binding capacity, and total antioxidant capacity (TAC). (
  • The authors of this study documented a significant, dose-dependent decrease in the number of inflammatory cells, concentration of protein, and levels of nitric oxide, pyrogenic prostaglandin E 2 and tumor necrosis factor alpha (TNFα) in the aqueous humor of the chokeberry extract-treated animals. (
  • Participants in a MBSR intervention group saw a decrease in adrenocorticotropic hormone, interleukin-6, and tumor necrosis factor-alpha. (
  • Having been traditionally utilized as a marker of infection and cardiovascular events, there is now growing evidence that CRP plays important roles in inflammatory processes and host responses to infection including the complement pathway, apoptosis, phagocytosis, nitric oxide (NO) release, and the production of cytokines, particularly interleukin-6 and tumor necrosis factor-α. (
  • Transcriptional induction of the CRP gene mainly occurs in hepatocytes in the liver in response to increased levels of inflammatory cytokines, especially interleukin-6 (IL-6) ( 5 ). (
  • The available information indicates that tumor cells secrete factors that alter the activity of fibroblasts in the supporting stroma, which in turn secrete extracellular matrix (ECM) 1 proteins and cytokines that modify the biology and activity of the cancer cells ( 1 ). (
  • It was found that most significant addition markers of tumor progression with presence of DTC in BM are the levels of cytokines such as TNF in BM and PB, CSF-1 and IL-6 in PB and endogenous IFN in BM and PB of BC patients. (
  • Based on the fact that cancer is a systemic process the level of certain cytokines associated with tumor growth, may serve as an additional important factors for prediction BC recurrence. (
  • Cytokines which may affect the cancer progression are tumor necrosis factor-α (TNF-α), colony stimulating factors (such as M-CSF (CSF-1)), interleukin 6 (IL-6), interferon (IFN), vascular endothelial growth factor (VEGF) and transforming growth factor β1 (TGF-β1) and others. (
  • For example, in vascular endothelial cells and monocytes, SAA greatly induced secretion of cytokines such as interleukin (IL)-1β, IL-6, IL-8, IL-10, tumor necrosis factor-α (TNF-α), and macrophage inflammatory protein 1α (17-19). (
  • The aim of this study was to analyze the effect of supplementation with chokeberry ( Aronia melanocarpa ) juice on the levels of pro-inflammatory cytokines, hepcidin, and selected markers of iron metabolism in rowers subjected to exhaustive exercise. (
  • However, it is now clear that inflammatory cytokines such as tumour necrosis factor  (TNF-), interleukin 1 (IL-1), and IL-6 are overexpressed in RA joints and play an important role in its pathogenesis [5, 6]. (
  • In addition, the current view of the cytokine network in RA joints supports the notion that TNF- activates a cytokine cascade characterised by simultaneous production of proinflammatory cytokines such as IL-1 and IL-6, whereas anti-inflammatory cytokines such as IL-10 and soluble TNF receptor are suppressed [2, 7]. (
  • We especially examined whether the association for plasma PLP was independent of plasma levels of one-carbon metabolites and markers of inflammation, including not only CRP but also two other proinflammatory cytokines, tumor necrosis factor-α (TNF-α) and interleukin (IL)-6. (
  • Inflammation is involved in the pathophysiology of depression, and circulating inflammatory cytokines have been associated with depressive symptoms. (
  • Current research regarding inflammatory markers and depression involves measurement of circulating cytokines (and CRP) in plasma or serum. (
  • Although inflammatory cytokines, growth factors, or CD40/CD40 ligand (CD40L) are possible candidates, the mechanism of atherosclerotic plaque neovascularization remains unknown. (
  • Although the presence of EBV-DNA in peripheral blood cannot be regarded as a surrogate marker for EBER, the plasma EBV-DNA load at HL diagnosis is an indicator of disease activity and biological characteristics associated with negative prognosis. (
  • Tumor-associated tissue eosinophilia (TATE) may be associated either with good or poor patient prognosis [6-7] . (
  • In colorectal cancer, hematologic tumors, gastric cancer, lung cancer, gynecologic malignancies, and breast cancer, quantitative assessment of eosinophils in tumor tissue is proposed as one of the possible aspects of the histological evaluation, correlating to the patient prognosis [3,5,8-18] . (
  • Here we discuss the up-to-date concepts of definition and classification, theoretical views on tumour origin along with practical issues of clinical presentation, diagnostics, treatment and prognosis. (
  • Aim: to detect DTC in BM and determinate cytokine status of peripheral blood (PB) and BM of primary BC patients for prognosis of tumor recurrence. (
  • 6 Therefore, efforts to identify new additional predictive markers are of great importance to improve the surveillance of prognosis for unresectable HCC. (
  • These markers tend to be elevated following an acute coronary event, and higher levels predict a worse prognosis. (
  • In this study, we review present and high-quality evidences regarding the potential applications of inflammatory breast cancer associated microRNAs for diagnosis and prognosis of this lethal disease. (
  • All these pathological events due to a wide array of pathological and biological processes such as apoptosis, cell proliferations and tumorigeneses resulted from dysregulated miRNA expression [ 30 ], accounting for the possibility of miRNAs serving as valued molecular bio-markers for diagnosis and prognosis of tumors. (
  • Tumor-infiltrating lymphoplasmacytic cells are a key feature of medullary carcinoma of the breast (MCB), a distinct subtype of human breast cancer that, despite cytologically anaplastic characteristics, has a more favorable prognosis than other types of breast cancer. (
  • Importantly, these simplified definitions always included the histopathologic criteria of lymphoplasmacytic cell infiltrate, demonstrating its importance to the improved prognosis and suggesting that the host immune response is involved in restraining tumor growth. (
  • Hepatocellular carcinoma (HCC) is a highly malignant tumor with poor prognosis and high mortality. (
  • Numerous studies have demonstrated correlation between high expression levels of CRIPTO and malignant transformation, tumor invasiveness, metastatic spreading and hence poor prognosis [ 17 , 22 - 27 ]. (
  • Vitamin B 6 may lower risk of colorectal cancer by preventing aberrations in one-carbon metabolism or by anti-inflammatory effects. (
  • However, it remains unclear whether this association is mediated by other one-carbon cofactors and/or inflammatory factors, which may be associated with the risk of colorectal cancer ( 7 - 10 ). (
  • Methylation of this gene is a potential marker for the presence of colorectal cancer. (
  • Most studies focused on the role of Cripto in breast and colorectal cancer [ 17 - 20 ], in inflammatory conditions and also in a macaque model of neuroAIDS [ 21 ]. (
  • Baseline levels of the cytokine interleukin‐6 (IL‐6) are 5 pg/ml, establishing a minimum 10 10 ‐fold dynamic range of the plasma proteome when compared to the concentration of the most abundant protein, HSA, with about 50 mg/ml. (
  • In terms of pro-inflammatory cytokine production, mCRP increases interleukin-8 and monocyte chemoattractant protein-1 production, whereas nCRP has no detectable effect on their levels. (
  • OBJECTIVE: Interleukin-6 (IL-6) is a key pro-inflammatory and immune-modulatory cytokine of relevance for cardiovascular (CD) diseases. (
  • With increased SAA levels, the plasma levels of interleukin-6 and tumor necrosis factor-α were significantly increased. (
  • Various inflammatory markers (C-reactive protein, tumor necrosis factor-α, interleukin-2, interleukin-6, and interleukin-8) have been associated with AF. (
  • Furthermore, various inflammatory markers and mediators such as C-reactive protein (CRP), tumor necrosis factor (TNF)-α, interleukin (IL)-2, IL-6, IL-8, and monocyte chemoattractant protein (MCP)-1 have been linked with the presence or the outcome of AF ( 2 ). (
  • Plasma PLP levels were positively correlated with cold cereal intake and plasma levels of folate and vitamin B 12 (age- and smoking-adjusted partial correction r = 0.28-0.48) and slightly inversely correlated with body mass index ( r = −0.11) and plasma levels of homocysteine, C-reactive protein, tumor necrosis factor-α receptor 2, and interleukin-6 ( r = −0.23 to −0.14). (
  • The hormones studied were cortisol and adrenocorticotropic hormone (ACTH) and markers of inflammation were tumor necrosis factor (TNF)-alpha and interleukin (IL)-6. (
  • We tested correlations of not only intracellular but also circulating inflammatory markers with depressive symptoms assessed using the 10-item Center for Epidemiological Studies Depression Scale (CES-D). Intracellular markers included expression of interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), and both in PBMCs. (
  • C-reactive protein (CRP) is an acute inflammatory protein that increases up to 1,000-fold at sites of infection or inflammation. (
  • Although most promising markers are based on the current understanding of malaria immunopathogenesis, some are also focused more broadly on mechanisms of tissue damage and inflammation. (
  • The reasons of this increase are not fully understood (greater prevalence of traditional cardiovascular risks, consequences of treatment (NSAID) or biological inflammation). (
  • Because atherosclerosis is primarily a chronic inflammatory disease, clinical markers for inflammation are a useful indicator for identifying individuals at high risk of CVD. (
  • However, whether an elevated plasma level of SAA is a consequence of inflammation or has a direct effect on atherogenesis is unknown. (
  • The present review aims to provide an update on the association of inflammation and AF, including the impact of inflammatory markers on clinical presentation and outcome of AF patients. (
  • Finally, recent studies indicate that activated inflammatory cells and inflammatory mediators may confer a prothrombotic state by promoting endothelial damage/dysfunction and platelet activation in patients with AF, thus linking inflammation and thrombosis. (
  • C-reactive protein is the prototype marker of inflammation and is predominantly synthesized in hepatocytes as an acute-phase reactant ( 4 ). (
  • Rheumatoid arthritis (RA) is a systemic autoimmune disease characterised by inflammation of the synovia, synovial hyperplasia with increased cell density, and infiltration of inflammatory cells leading to pannus formation and irreversible cartilage and bone destruction [1]. (
  • However, the wealth of data suggesting that AA may be highly beneficial in addressing cancer-associated inflammation, particularly progression to systemic inflammatory response syndrome (SIRS) and multi organ failure (MOF), has been largely overlooked. (
  • In the context of cancer, inflammation may be seen as a continuum of possible degrees of severity ranging from low level, chronic inflammatory response to acute, highly severe inflammation. (
  • Elevated AFP levels can also be due to non-HCC factors like chronic liver ailments such as cirrhosis and hepatic inflammation and other cancer types like non-seminomatous germ cell tumors and gastrointestinal cancers [ 1 ]. (
  • This approach provided for the first time a snapshot of the protein components of the TIF, which we show consists of more than one thousand proteins-either secreted, shed by membrane vesicles, or externalized due to cell death-produced by the complex network of cell types that make up the tumor microenvironment. (
  • Today there is evidence indicating that tumor growth and progression is dependent on the malignant potential of the tumor cells as well as on the multidirectional interactions of local factors produced by all the cell types-tumor, stroma, endothelial cells, and immune and inflammatory cells-present in the local microenvironment (1-9 and references therein). (
  • With the advent of enabling technologies within proteomics, it is now feasible to undertake a systematic characterization of the proteins that are released to the interstitial space by all the cell types resident in the tumor microenvironment. (
  • Very important role in tumor progression plays microenvironment both the tumor and target-organ for the development of distant metastases, which consists of the cancer cells (for microenvironment of tumor) and the surrounding component (different type of cells: fibroblasts, endothelial cells, pericytes, immune cells, etc. (
  • In this review article, we present recent updates on the hematologic tumor microenvironment following the 3rd Scientific Workshop on the Haematological Tumour Microenvironment and its Therapeutic Targeting organized by the European School of Hematology, which took place at the Francis Crick Institute in London in February 2019. (
  • The content covers basic research and possible clinical applications with the major therapeutic angle of utilizing basic knowledge to devise new strategies to target the tumor microenvironment in hematologic cancers. (
  • Increasingly high morbidity rates impose a search for more relevant prognostic and predictive markers for tumors in stage pTa and pT1. (
  • The source, biological effect, and prognostic role of the main inflammatory markers associated with AF are summarized in Table 1 . (
  • Human breast cancers can be divided into histopathologic subtypes with distinct biological and prognostic characteristics. (
  • These data demonstrate the high diagnostic and prognostic potential of methylation markers in the plasma of HCC patients. (
  • [5] As one of the chief components of the extracellular matrix , hyaluronan contributes significantly to cell proliferation and migration, and may also be involved in the progression of some malignant tumors . (
  • In BC progression special role play inflammatory mediators like TNF-α and IL-6. (
  • It was found that TNF-α is expressed at very low incidence in normal breast epithelial cells but it incidence is significantly elevated in tumor cells which suggest progression-related roles TNF-α in BC [4]. (
  • Thus, an increase in plasma SAA directly accelerates the progression of atherosclerosis in ApoE −/− mice. (
  • However, although AFP is poor for early HCC detection, serum AFP levels are efficient in predicting the disease outcome and monitoring tumor progression in AFP-producing HCC patients. (
  • Consequently, maladapted tumor-associated vascular endothelial cells may confer stem cell-like activity to indolent tumor cells. (
  • 2 Another example is the abnormal activation of the fibro blast growth factor receptor 1 (FGFR1)-ETS2 pathway in tumor-associated-vascular endothelial cells during chemotherapy. (
  • Cripto has also a role in angiogenesis, being able to enhance the proliferation, migration and invasion of human umbilical endothelial cells, to stimulate their differentiation into vascular-like structures in Matrigel and is also able to induce tumor neovascularization in vivo [ 13 ]. (
  • Regulation of p53 tumour suppressor target gene expression by the p52 NF-kappaB subunit. (
  • Genes of the SFRP family are tumor suppressor genes that are frequently silenced by DNA hypermethylation in many cancer types. (
  • The lung cancer in the Republic of Kazakhstan makes up 11.4 % of the total number of malignant tumors. (
  • Worldwide, prostate cancer (PCa) is the second cause of death from malignant tumors among men. (
  • Besides the phenotypic properties of the tumor parenchymal cells, possible signs in regard to recurrence could also be derived from the peculiarities of the tumor stroma. (
  • Since it has been proposed that the improved clinical outcome is due at least in part to the presence of a prominent lymphoplasmacytic cell infiltrate in the tumor stroma, we recently examined the tumor-infiltrating B cell response in MCB and showed that it is oligoclonal and directed against an intracellular protein translocated to the cell surface upon MCB cell apoptosis. (
  • MCB is characterized by prominent lymphoplasmacytic infiltrates in the tumor stroma. (
  • Background: In recent years, the presence of disseminated tumor cells (DTC) in bone marrow (BM) of patients with breast cancer (BC) is considered as an important clinical feature of the distribution process. (
  • The presence of circulating tumor cells (CTC) in PB and disseminated tumor cells (DTC) in BM BC patients has been proven to have clinical relevance [2]. (
  • The objective of our investigation was to determine whether short and/or long sleep duration and, in a separate analysis, snoring are associated with increased total or LDL cholesterol, triglycerides, leptin, or inflammatory markers C-reactive protein (CRP), lipoprotein(a), soluble E-selectin, soluble intercellular adhesion molecule-1 (sICAM-1), and soluble tumor necrosis factor (TNF)-α receptor II and/or decreased HDL cholesterol or adiponectin levels. (
  • However, there have been few studies to determine plasma high-sensitivity C-reactive protein (hs-CRP) levels in young diabetic patients ( 7 , 8 ). (
  • The core SNARE synaptosomal-associated protein of 25 kDa (SNAP25) accumulates in the plasma membrane of nerve terminals at NMJs and regulates exocytosis at peripheral and central synapses. (
  • C-reactive protein is a homopentameric acute-phase inflammatory protein, a highly conserved plasma protein that was initially discovered in 1930 by Tillet and Francis while investigating the sera of patients suffering from the acute stage of Pneumococcus infection and was named for its reaction with the capsular (C)-polysaccharide of Pneumococcus ( 1 ). (
  • C-reactive protein exhibits elevated expression during inflammatory conditions such as rheumatoid arthritis, some cardiovascular diseases, and infection ( 6 ). (
  • Auf finden Sie aktuell 76 Macrophage Inflammatory Protein Related Protein 1 (MRP1) Antikörper von 14 unterschiedlichen Herstellern. (
  • Zusätzlich bieten wir Ihnen Macrophage Inflammatory Protein Related Protein 1 Proteine (7) und Macrophage Inflammatory Protein Related Protein 1 Kits (4) und viele weitere Produktgruppen zu diesem Protein an. (
  • Insgesamt sind aktuell 88 Macrophage Inflammatory Protein Related Protein 1 Produkte verfügbar. (
  • This review article discusses the impact of tumor pre-analytics on molecular pathology focusing on biospecimen protein expression and analysis. (
  • Here, we aim to discuss and review the effects of tumor pre-analytics on protein expression resulting in modification of in vivo protein status. (
  • Circulating markers included IL-6, TNF-α, and C-reactive protein (CRP) in plasma. (
  • Furthermore, certain miRNAs also function as tumour oncogenes or suppressors in different cancers. (
  • Because aberrant DNA methylation of genes and miRNAs occurs early in most cancers, we explored whether circulating methylation markers could be promising clinical tools for HCC diagnosis. (
  • Some studies support the opinion that eosinophils may have a role in tumor initiation [7] . (
  • One feature of this profile was an elevated plasma levels of soluble TNF receptor I (sTNFRI). (
  • It is now well established that the acute phase response may take place in extra-hepatic cell types, and may be regulated by inflammatory mediators as observed in hepatocytes. (
  • Chronic treatment caused weight and fat mass loss, increased energy expenditure, enhanced glucose tolerance and insulin sensitivity, normalized plasma lipids, and induced broad suppression of inflammatory markers. (
  • Receptor CD44 participates in cell adhesion interactions required by tumor cells. (
  • Although hyaluronan binds to receptor CD44, there is evidence hyaluronan degradation products transduce their inflammatory signal through toll-like receptor 2 ( TLR2 ), TLR4 , or both TLR2 and TLR4 in macrophages and dendritic cells . (
  • In metastatic PDAC tissue ANXA1 and ANXA10 showed similar staining behavior as in the primary PDAC tumors (13/18 and 17/18 positive, respectively). (
  • We conclude that ANXA1 and ANXA10 are promising biomarker candidates with high diagnostic values for the differential diagnosis of intrahepatic CCC and metastatic liver tumors deriving from PDAC. (
  • MAS is a severe systemic inflammatory condition due to excessive activation and proliferation of T cells and well-differentiated macrophages. (
  • The presence of EBV in HRS cells and higher plasma EBV-DNA copy numbers correlated to an increased frequency of tumor-infiltrating CD68+ macrophages in lymph node biopsies. (
  • Since plasma EBV-DNA may be absent in patients with limited disease, EBV-DNA cannot be regarded as a surrogate marker for EBV-encoded small RNAs, and study of EBV in Hodgkin/Reed-Sternberg cells is still the gold standard recommended for screening for EBV association in HL. (
  • Here, we address this problem by comparing microdissected CCC and PDAC tumor cells from nine and eleven cancer patients, respectively, in a label-free proteomics approach. (
  • In this regard, possible signs may be derived from some stromal characteristics, such as the presence of eosinophilic leukocytes, mast cells, lymphocytes, plasma cells, fibroblasts and myoepithelial cells. (
  • Some of these proteins represent important candidates for cancer therapy targeting the complex and dynamic network of interactions that modulate the biology and activity of tumor cells ( 29 , 31 - 34 ). (
  • However, a maladapted vascular niche can facilitate the expansion of tumor-initiating cells in different organs. (
  • The prospective use of novel collection vials, which stabilize blood cells and reduce background DNA contamination in serum/plasma samples, will facilitate clinical implementation of liquid biopsy analyses. (
  • Interestingly, the tumor-infiltrating B cells in half the MCB patients mainly exhibited an IgG2 response, while IgG1 dominated in the others. (
  • We propose that the Ab response against actin produced by tumor-infiltrating B lymphoplasmacytic cells is Ag-driven, affinity-matured, and elicited due to the increased rate of apoptosis occurring within the MCB tumor that facilitates the translocation and proteolytic fragmentation of intracellular proteins. (
  • however, recent studies have demonstrated alterations in the p53 gene in nearly 100% of MCBs and immunohistochemically verified accumulation of p53 in the nuclei of tumor cells in MCBs ( 8 , 9 , 10 , 11 ). (
  • Although serum amyloid A (SAA) is an excellent marker for coronary artery disease, its direct effect on atherogenesis in vivo is obscure. (
  • Clinically relevant and exact measurements of specific markers for several different autoimmune conditions, such as rheumatoid arthritis and celiac disease, are available. (
  • 8 ] showed that chokeberry extract exerts strong anti-inflammatory effects during endotoxin-induced uveitis in rats. (
  • The number of published research documenting anti-inflammatory effects of flavonoids in the context of exercise-induced changes is sparse. (
  • The proteins constituting the plasma proteome can be categorized into three different classes (Fig 1 A and B). The first contains abundant proteins with a functional role in blood. (
  • A) Concentration range of plasma proteins with the gene names of several illustrative blood proteins (red dots). (
  • Increased plasma concentrations of acute-phase proteins have been reported in adult patients with either type 2 ( 3 , 4 ) or type 1 ( 5 , 6 ) diabetes. (
  • noted that in plasma, ORM proteins are presented as a mixture of ORM1 and ORM2 proteins in a molar ratio of 3:1, respectively. (
  • In the present study, we looked at eight circulating plasma proteins to characterize microvascular dysfunction in the specific setting of PAH associated with congenital heart disease and to determine if they reflected the severity of the disease. (
  • As other GPI linked proteins such as the carcinoembryonic antigen (CEA), one of the most used tumor markers, CRIPTO is able to reach the bloodstream. (
  • The authors of this study expanded on this prior work by measuring inflammatory biomarker and stress hormone changes from chronic or repeated stress in patients with GAD. (
  • determined whether depressed patients with established CHD have higher levels of inflammatory markers following an acute coronary event when judged against comparable nondepressed patients. (
  • The majority of malignant neoplasms located in the liver are metastases originating from primary tumor sites in other organs, most commonly the colon or the pancreas ( 1 ). (
  • In this hypothesis, identification of this profile, that is feasible with only 3 markers with an error rate of 5%, might allow to personalize the screening and prevention of metabolic syndrome-driven morbidities as liver steatosis. (
  • We were interested in the detection and quantification of cell-free plasma EBV-DNA as an indicator of biological and clinical characteristics in EBV-associated HL. (
  • Detection of EBV-DNA in plasma had a high specificity (90%), but a relatively low sensitivity (65%) to predict for EBV association. (
  • Clinical cancer proteomics aims at the identification of markers for early detection and predictive purposes, as well as to provide novel targets for drug discovery and therapeutic intervention. (
  • It is now possible to detect CTCs in the PB and DTCs in the BM by using immunocytochemical analysis which include staining with monoclonal antibodies against epithelial or tumor-associated antigens and molecular methods which are based on detection specific nucleotide sequences (real-time PCR, reverse transcription - PCR) [3]. (
  • The most commonly used marker for HCC detection is serum alpha fetoprotein (AFP), which has low sensitivity and specificity. (
  • The hyperactivated but dysregulated immune responses lead to overwhelming inflammatory responses resulting in non-remitting high fever, hepatomegaly and splenomegaly, lymphadenopathy, haemorrhage and central nervous system dysfunction [ 17 ]. (
  • The effect of mindfulness meditation on biological acute stress responses in generalized anxiety disorder. (
  • In 2013, they hypothesized that decreasing biological stress responses may improve overall cardiovascular and metabolic health, although that was not measured for this study. (
  • Furthermore, because psychosocial and physiological stressors activate inflammatory responses and LPS-stimulated ICCs reflect the inflammatory responsivity of monocytes to such stressors, ICCs may reflect individual stress responsivity. (
  • Pseudouridine represents a potential novel risk factor for ovarian cancer and triglycerides may be important particularly in rapidly fatal ovarian tumors. (
  • MicroRNAs are a class of small non-coding RNAs that are capable to post-transcriptionally regulate gene expression of genes by targeting mRNAs, exerting vital and tremendous affects in numerous malignancy-related biological processes, including cell apoptosis, metabolism, proliferation and differentiation. (
  • The stromal reaction, manifested by inflammatory infiltration in the tumor is considered to influence the biological behavior of tumors. (
  • Atherosclerosis is an inflammatory disease of the vascular wall, leading to lipid accumulation, macrophage infiltration, and subsequent focal thickening of the intimal layer of arteries. (
  • Upregulation of CD44 itself is widely accepted as a marker of cell activation in lymphocytes. (
  • Discovering and identifying novel bio-markers responsible for diagnosis and therapeutic targets is a pressing need. (
  • The liquid portion is called plasma, when all components are retained, and serum, when the coagulation cascade has been activated (blood clotting). (
  • For simplicity, we will use the term "plasma" rather than "serum", since most conclusions apply to both. (
  • Concentrations are in serum or plasma and measured with diverse methods as retrieved from the plasma proteome database in May 2017 ( ) (Nanjappa et al , 2014 ). (
  • The serum alpha-fetoprotein (AFP) remains the most widely used marker for HCC screening and surveillance inspite of its poor sensitivity and specificity. (
  • Therefore, there is a need to verify if and to what extent, supplementation with polyphenol-rich chokeberry juice may alter the inflammatory indices of elite athletes subjected to intensive exercise load. (
  • Since May 2009, the majority of patients in the US with an initial recurrence of high-grade glioma receive bevacizumab, a monoclonal antibody against vascular endothelial growth factor (VEGF), which is thought to prevent angiogenesis in these highly vascular tumors. (
  • The commitment of the digestive organs observed in patients during the chronic phase of Chagas' disease is mainly attributed to neuronal damage induced by immune and inflammatory processes elicited by the presence of Trypanosoma cruzi. (
  • By measuring 43 markers of immune, endothelial, and coagulation activation, we have previously shown that five different immune activation profiles may be distinguished in 150 volunteers. (
  • Popov H, Donev I S, Ghenev P (September 10, 2018) Quantitative Analysis of Tumor-associated Tissue Eosinophilia in Recurring Bladder Cancer. (
  • We measured plasma levels of VWF:Ag, tissue-type plasminogen activator (t-PA), plasminogen activator inhibitor 1 (PAI-1) and P-selectin to monitor endothelial dysfunction. (
  • Increasing the power of tumour control and normal tissue complication probability modelling in radiotherapy: recent. (
  • Concentrations of various plasma components are routinely determined in clinical practice. (
  • In addition, the large NKTR-102 molecule does not freely pass out of intact vasculature, which may account for relatively higher concentrations of the compound and the active metabolites in tumor tissues in in vivo models, where the local vasculature may be relatively more permeable. (
  • Exclusion criteria were hypertension, overweight or obesity, smoking, any infection having been diagnosed during the previous 3 months, and treatment for inflammatory or chronic infectious disease. (
  • Inflammatory markers and stress hormones fluctuate with chronic or repeated stress. (
  • Taken together, these markers can help optimise therapeutic strategies and reduce disease burden. (
  • SNARE complex and, in particular, SNAP25 may represent a promising pathway to explore the molecular and cellular mechanisms regulating muscular homeostasis and concur at profiling the sarcopenia biological background. (
  • Leukocyte activation is considered an important inflammatory pathway underlying AF ( 3 ). (
  • the tumors that have relapsed within six months after removal and contained statistically significant greater numbers of eosinophils in primary cancer sites. (
  • Model parameters are derived by mathematical fits to clinical observations and are subsequently used to estimate the risk of tumour relapse or toxicity. (
  • Current research in this field mainly focuses on the impact of inflammatory markers on clinical presentation and outcome of AF and it further aims to address four important questions. (
  • SAA is not only a risk marker for atherosclerosis but also an active participant in atherogenesis. (
  • In the present study, we investigated whether markers of macrophage activation syndrome (MAS) can be used as differential diagnostic markers of severe dengue. (
  • In addition to the widely used methods of clinical diagnostics of cancer diseases, to date, a large amount of evidence has been accumulated about the involvement of microRNA in the carcinogenesis of various tumors, including lung cancer [5]. (
  • Inflammatory breast cancer (IBC) is an infrequent but aggressive manifestation of breast cancer, which accounts for 2-4% of all breast cancer cases but responsible for 7-10% of breast cancer-related deaths, and with a 20-30% 10-year overall survival compared with 80% for patients with non-IBC with an unordinary phenotype, whose molecular mechanisms are still largely unknown to date. (