###### Area Under Curve

A statistical means of summarizing information from a series of measurements on one individual. It is frequently used in clinical pharmacology where the AUC from serum levels can be interpreted as the total uptake of whatever has been administered. As a plot of the concentration of a drug against time, after a single dose of medicine, producing a standard shape curve, it is a means of comparing the bioavailability of the same drug made by different companies. (From Winslade, Dictionary of Clinical Research, 1992)

###### Biological Availability

###### Cross-Over Studies

Studies comparing two or more treatments or interventions in which the subjects or patients, upon completion of the course of one treatment, are switched to another. In the case of two treatments, A and B, half the subjects are randomly allocated to receive these in the order A, B and half to receive them in the order B, A. A criticism of this design is that effects of the first treatment may carry over into the period when the second is given. (Last, A Dictionary of Epidemiology, 2d ed)

###### Half-Life

###### Therapeutic Equivalency

###### Coroners and Medical Examiners

###### Food-Drug Interactions

###### Metabolic Clearance Rate

###### Cytochrome P-450 CYP3A

A cytochrome P-450 suptype that has specificity for a broad variety of lipophilic compounds, including STEROIDS; FATTY ACIDS; and XENOBIOTICS. This enzyme has clinical significance due to its ability to metabolize a diverse array of clinically important drugs such as CYCLOSPORINE; VERAPAMIL; and MIDAZOLAM. This enzyme also catalyzes the N-demethylation of ERYTHROMYCIN.

###### Magnesium Hydroxide

###### Suspensions

###### Tablets

###### Herb-Drug Interactions

###### Chromatography, High Pressure Liquid

###### Ketoconazole

###### Decapodiformes

###### Delayed-Action Preparations

###### Aryl Hydrocarbon Hydroxylases

A large group of cytochrome P-450 (heme-thiolate) monooxygenases that complex with NAD(P)H-FLAVIN OXIDOREDUCTASE in numerous mixed-function oxidations of aromatic compounds. They catalyze hydroxylation of a broad spectrum of substrates and are important in the metabolism of steroids, drugs, and toxins such as PHENOBARBITAL, carcinogens, and insecticides.

###### Mathematics

###### 14-alpha Demethylase Inhibitors

###### Tick Control

###### Biotransformation

The chemical alteration of an exogenous substance by or in a biological system. The alteration may inactivate the compound or it may result in the production of an active metabolite of an inactive parent compound. The alterations may be divided into METABOLIC DETOXICATION, PHASE I and METABOLIC DETOXICATION, PHASE II.

###### Sulfanilamides

###### Ranvier's Nodes

###### Dose-Response Relationship, Drug

###### Midazolam

A short-acting hypnotic-sedative drug with anxiolytic and amnestic properties. It is used in dentistry, cardiac surgery, endoscopic procedures, as preanesthetic medication, and as an adjunct to local anesthesia. The short duration and cardiorespiratory stability makes it useful in poor-risk, elderly, and cardiac patients. It is water-soluble at pH less than 4 and lipid-soluble at physiological pH.

###### Terfenadine

###### Sodium

###### Membrane Potentials

The voltage differences across a membrane. For cellular membranes they are computed by subtracting the voltage measured outside the membrane from the voltage measured inside the membrane. They result from differences of inside versus outside concentration of potassium, sodium, chloride, and other ions across cells' or ORGANELLES membranes. For excitable cells, the resting membrane potentials range between -30 and -100 millivolts. Physical, chemical, or electrical stimuli can make a membrane potential more negative (hyperpolarization), or less negative (depolarization).

###### Itraconazole

###### Tissue Distribution

Accumulation of a drug or chemical substance in various organs (including those not relevant to its pharmacologic or therapeutic action). This distribution depends on the blood flow or perfusion rate of the organ, the ability of the drug to penetrate organ membranes, tissue specificity, protein binding. The distribution is usually expressed as tissue to plasma ratios.

###### Drug Combinations

###### Double-Blind Method

###### P-Glycoprotein

A 170-kDa transmembrane glycoprotein from the superfamily of ATP-BINDING CASSETTE TRANSPORTERS. It serves as an ATP-dependent efflux pump for a variety of chemicals, including many ANTINEOPLASTIC AGENTS. Overexpression of this glycoprotein is associated with multidrug resistance (see DRUG RESISTANCE, MULTIPLE).

###### Antifungal Agents

###### Ion Channels

###### Sodium Channels

###### Absorption

###### Cochlear Microphonic Potentials

###### Models, Biological

###### Prodrugs

###### Models, Theoretical

###### Spectrophotometry, Ultraviolet

###### Rifampin

A semisynthetic antibiotic produced from Streptomyces mediterranei. It has a broad antibacterial spectrum, including activity against several forms of Mycobacterium. In susceptible organisms it inhibits DNA-dependent RNA polymerase activity by forming a stable complex with the enzyme. It thus suppresses the initiation of RNA synthesis. Rifampin is bactericidal, and acts on both intracellular and extracellular organisms. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p1160)

###### Ritonavir

###### Diffusion

###### Anura

###### Potassium

An element in the alkali group of metals with an atomic symbol K, atomic number 19, and atomic weight 39.10. It is the chief cation in the intracellular fluid of muscle and other cells. Potassium ion is a strong electrolyte that plays a significant role in the regulation of fluid volume and maintenance of the WATER-ELECTROLYTE BALANCE.

###### HIV Protease Inhibitors

###### Organic Anion Transporters

###### Action Potentials

###### Solubility

###### Carbon Radioisotopes

###### Anti-Infective Agents

###### Infusions, Intravenous

###### Genotype

###### Refeeding Syndrome

A condition of metabolic imbalance that is caused by complications of initially feeding a severely malnourished patient too aggressively. Usually occurring within the first 5 days of refeeding, this syndrome is characterized by WATER-ELECTROLYTE IMBALANCE; GLUCOSE INTOLERANCE; CARDIAC ARRHYTHMIAS; and DIARRHEA.

###### Rats, Sprague-Dawley

###### Drug Administration Schedule

###### Transverse Sinuses

The two large endothelium-lined venous channels that begin at the internal occipital protuberance at the back and lower part of the CRANIUM and travels laterally and forward ending in the internal jugular vein (JUGULAR VEINS). One of the transverse sinuses, usually the right one, is the continuation of the SUPERIOR SAGITTAL SINUS. The other transverse sinus is the continuation of the straight sinus.

###### Tetrodotoxin

###### Omeprazole

###### Drug Carriers

Forms to which substances are incorporated to improve the delivery and the effectiveness of drugs. Drug carriers are used in drug-delivery systems such as the controlled-release technology to prolong in vivo drug actions, decrease drug metabolism, and reduce drug toxicity. Carriers are also used in designs to increase the effectiveness of drug delivery to the target sites of pharmacological actions. Liposomes, albumin microspheres, soluble synthetic polymers, DNA complexes, protein-drug conjugates, and carrier erythrocytes among others have been employed as biodegradable drug carriers.

###### Algorithms

###### Asian Continental Ancestry Group

###### Tandem Mass Spectrometry

A mass spectrometry technique using two (MS/MS) or more mass analyzers. With two in tandem, the precursor ions are mass-selected by a first mass analyzer, and focused into a collision region where they are then fragmented into product ions which are then characterized by a second mass analyzer. A variety of techniques are used to separate the compounds, ionize them, and introduce them to the first mass analyzer. For example, for in GC-MS/MS, GAS CHROMATOGRAPHY-MASS SPECTROMETRY is involved in separating relatively small compounds by GAS CHROMATOGRAPHY prior to injecting them into an ionization chamber for the mass selection.

###### Injections, Intramuscular

###### Anti-HIV Agents

###### Cytochrome P-450 Enzyme System

A superfamily of hundreds of closely related HEMEPROTEINS found throughout the phylogenetic spectrum, from animals, plants, fungi, to bacteria. They include numerous complex monooxygenases (MIXED FUNCTION OXYGENASES). In animals, these P-450 enzymes serve two major functions: (1) biosynthesis of steroids, fatty acids, and bile acids; (2) metabolism of endogenous and a wide variety of exogenous substrates, such as toxins and drugs (BIOTRANSFORMATION). They are classified, according to their sequence similarities rather than functions, into CYP gene families (>40% homology) and subfamilies (>59% homology). For example, enzymes from the CYP1, CYP2, and CYP3 gene families are responsible for most drug metabolism.

###### Disease Outbreaks

###### Stereoisomerism

###### Rabbits

###### Drug Therapy, Combination

###### Models, Statistical

###### Dogs

###### Temperature

###### Computer Simulation

###### Electrophysiology

###### Asteraceae

A large plant family of the order Asterales, subclass Asteridae, class Magnoliopsida. The family is also known as Compositae. Flower petals are joined near the base and stamens alternate with the corolla lobes. The common name of "daisy" refers to several genera of this family including Aster; CHRYSANTHEMUM; RUDBECKIA; TANACETUM.

###### Antimalarials

###### Liposomes

###### Intestines

###### Neoplasms

###### Models, Genetic

###### Case-Control Studies

Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.

###### Antiviral Agents

Agents used in the prophylaxis or therapy of VIRUS DISEASES. Some of the ways they may act include preventing viral replication by inhibiting viral DNA polymerase; binding to specific cell-surface receptors and inhibiting viral penetration or uncoating; inhibiting viral protein synthesis; or blocking late stages of virus assembly.

###### Pyrimidines

###### Treatment Outcome

###### Feces

###### Polymorphism, Genetic

The regular and simultaneous occurrence in a single interbreeding population of two or more discontinuous genotypes. The concept includes differences in genotypes ranging in size from a single nucleotide site (POLYMORPHISM, SINGLE NUCLEOTIDE) to large nucleotide sequences visible at a chromosomal level.

###### Models, Chemical

###### Basal Ganglia Cerebrovascular Disease

A pathological condition caused by impaired blood flow in the basal regions of cerebral hemispheres (BASAL GANGLIA), such as INFARCTION; HEMORRHAGE; or ISCHEMIA in vessels of this brain region including the lateral lenticulostriate arteries. Primary clinical manifestations include involuntary movements (DYSKINESIAS) and muscle weakness (HEMIPARESIS).

###### Models, Neurological

###### Reference Values

###### Mass Spectrometry

###### Analysis of Variance

###### Reproducibility of Results

The statistical reproducibility of measurements (often in a clinical context), including the testing of instrumentation or techniques to obtain reproducible results. The concept includes reproducibility of physiological measurements, which may be used to develop rules to assess probability or prognosis, or response to a stimulus; reproducibility of occurrence of a condition; and reproducibility of experimental results.

###### Urinary Diversion

Temporary or permanent diversion of the flow of urine through the ureter away from the URINARY BLADDER in the presence of a bladder disease or after cystectomy. There is a variety of techniques: direct anastomosis of ureter and bowel, cutaneous ureterostomy, ileal, jejunal or colon conduit, ureterosigmoidostomy, etc. (From Campbell's Urology, 6th ed, p2654)

###### Hydrogen-Ion Concentration

###### Martin Lopez

Lopez then shifted

**concentration**to his old band, Fifth to**Infinity**. On 28 May 2010, it was announced that Martin Lopez, ...###### Dynamic equilibrium

As time tends towards

**infinity**, the**concentrations**[A]t and [B]t tend towards constant values. Let t approach**infinity**, that is ... with a**concentration**[A]0, the sum of the two**concentrations**, [A]t and [B]t, at time t, will be equal to [A]0. d [ A ] d t = − ... Since the**concentrations**do not change thereafter, they are, by definition, equilibrium**concentrations**. Now, the equilibrium ... The**concentration**of carbon dioxide in the liquid has decreased and the drink has lost some of it fizzes. Henry's law may be ...###### Area under the curve (pharmacokinetics)

The AUC (from zero to

**infinity**) represents the total drug exposure across time. AUC is a useful metric when trying to determine ... AUC becomes useful for knowing the average**concentration**over a time interval, AUC/t. Also, AUC is referenced when talking ... This is often measured by quantifying the "AUC". In order to determine the respective AUCs, the serum**concentration**vs. time ... the drug**concentration**is measured at certain discrete points in time and the trapezoidal rule is used to estimate AUC. ...###### Rate equation

be the

**concentration**of A at equilibrium. Then: −. d. [. A. ]. d. t. =. k. f. [. A. ]. t. −. k. b. [. B. ]. t. −. d. x. d. t. = ... This applies even when time t is at**infinity**; i.e., equilibrium has been reached: [. A. ]. e. =. [. A. ]. 0. −. [. B. ]. e. {\ ...**Concentration**of B is related to that of C through [. B. ]. =. −. k. 1. ′. k. 2. l. n. (. 1. −. [. C. ]. [. R. ]. 0. ). {\ ... The**concentration**of A at time t, [. A. ]. t. {\displaystyle [{\ce {A}}]_{t}}. , is related to the**concentration**of B at time t ...###### Neuroscience of religion

The meditators feel that they have touched

**infinity**."[11] The radical Catholic theologian Eugen Drewermann developed a two- ... "If you block sensory inputs to this region, as you do during the intense**concentration**of meditation, you prevent the brain ...###### Ostwald ripening

When all small particles do this, it increases the

**concentration**of free molecules in solution. When the free molecules in ... As time trends to**infinity**, the entire population of particles becomes one large spherical particle to minimize the total ...###### Boltzmann-Matano analysis

... and the

**concentration**profile is virtually "frozen". The**concentration**profile c at time t can then be extracted as a function ... 0 {\displaystyle c=c_{R}\qquad \forall x>0} Also, the alloys on both sides are assumed to stretch to**infinity**, which means in ... that is the**concentration**curve "flattens out" when approaching the limit**concentration**value. We can then rearrange: D ( c ... XM is the average position weighed on**concentrations**, and can be easily found from the**concentration**profile providing it is ...###### Michael A. Wiener

"

**Infinity**co-founder Michael Wiener has died" Archived 2009-08-08 at the Wayback Machine, Radio Business Report, August 3, 2009 ... under new regulations enacted under the Telecommunications Act of 1996 that allowed greater**concentration**of ownership in the ... As the company grew, both Wiener and Carrus left their day jobs to work full-time at**Infinity**. Wiener was the company's ... Over the next decade, Karmazin led**Infinity**on a buying spree and brought in shock jock Howard Stern, moving the business into ...###### Al Taylor (politician)

He later earned a Master of Divinity, with a

**concentration**in church development, from the Alliance Theological Seminary. ... while also serving as a Democratic district leader and as the pastor of**Infinity**Mennonite Church. Farrell, first elected in ...###### Maximum likelihood estimation

In mathematical terms this means that as n goes to

**infinity**the estimator θ ^ {\displaystyle {\widehat {\theta \,}}} converges ... other estimators may have greater**concentration**around the true parameter-value. However, like other estimation methods, ... it achieves the Cramér-Rao lower bound when the sample size tends to**infinity**. This means that no consistent estimator has ... maximum likelihood estimation possesses a number of attractive limiting properties: As the sample size increases to**infinity**, ...###### Implicit solvation

... represents the

**concentration**of the ion i at a distance of**infinity**from the solute, z i {\displaystyle z_{i}} is the valence ... from partition coefficients of these compounds between different solutions or media using standard mole**concentrations**of the ...###### Illustrative model of greenhouse effect on climate change

Thus the effect of a relative change in CO2

**concentration**, dN/N = dn0/n0 (where n0 is the density number near ground), would be ... and the**infinity**here can be taken actually as the top of the tropopause. ... Huang, Y., & Bani Shahabadi, M. (2014). Why logarithmic? A note on the dependence of radiative forcing on gas**concentration**. ... A relative increase in the CO2**concentration**means an equal relative increase in the total CO2 content of the atmosphere, dN/N ...###### Vitali Milman

Milman's proof gives the optimal bound d(N) ≥ const log N. In this proof, Milman put forth the

**concentration**of measure ... tending to**infinity**with N, that is arbitrarily close to being isometric to an ellipsoid. ... Milman, Vitali D. (1986). "The**concentration**phenomenon and linear structure of finite-dimensional normed spaces". Proceedings ...###### Clearance (pharmacology)

Co is the

**concentration**at the beginning of dialysis or the initial**concentration**of the substance/drug (after it has ... at time**infinity**(steady state) is: The above equation (10a) can be rewritten as: The above equation (10b) makes clear the ... is the first derivative of**concentration**with respect to time, i.e. the change in**concentration**with time. It is derived from a ... clearance is generally dependent on the total**concentration**(free + protein-bound) and not the free**concentration**. Most plasma ...###### Azuma's inequality

In probability theory, the Azuma-Hoeffding inequality (named after Kazuoki Azuma and Wassily Hoeffding) gives a

**concentration**... approaches 0 as n goes to**infinity**. A similar inequality was proved under weaker assumptions by Sergei Bernstein in 1937. ...**Concentration**inequality - a summary of tail-bounds on random variables. It is not a direct application of Hoeffding's lemma ...###### Cinnarizine

AUC∞, (the area under the curve extrapolated to

**infinity**) which can be used to estimate bioavailability, was 4437 +/- 948 (ng.h ... Once ingested, the substance is absorbed quite rapidly and reaches a peak plasma**concentration**in 1-3 hours post-administration ... have shown that chronic treatment with cinnarizine builds the drug**concentrations**high enough that they interfere with the ... The IC50 (half-maximal inhibitory**concentration**) of cinnarizine for smooth muscle contraction inhibition is 60mM and it has ...###### Caustic (optics)

Play media

**Concentration**of light, especially sunlight, can burn. The word caustic, in fact, comes from the Greek καυστός, ... In ideal circumstances (including perfectly parallel rays, as if from a point source at**infinity**), a nephroid-shaped patch of ...###### Fracture mechanics

In theory the stress at the crack tip where the radius is nearly zero, would tend to

**infinity**. This would be considered a ... In actuality, the stress**concentration**at the tip of a crack within real materials has been found to have a finite value but ... Rice, J. R. (1968), "A path independent integral and the approximate analysis of strain**concentration**by notches and cracks" ( ... with a geometry dependent region of stress**concentration**replacing the crack-tip singularity. ...###### Inhibition theory

0 and c1 > 0. Note that, according to the first assumption, as y goes to M (during an interval), ℓ1(y) goes to

**infinity**and ... 6). New York: The MacMillan Company.' Smit, J. C. and van der Ven, A. H. G. S. (1995). Inhibition in Speed and**Concentration**... goes to**infinity**and this forces a transition to a state of work before the inhibition can reach zero. For a work interval ... in the Attention**Concentration**Test, is referred to as A. The average stationary response time E(T) may be written as E ( T ...###### Zachary Claman DeMelo

One of Claman DeMelo's grandmothers spent time in a Nazi

**concentration**camp. She was freed on a Friday the 13th, and the tattoo ...**infinity**management. 18 August 2015. Archived from the original on 25 February 2017. "Canadian Zachary Claman DeMelo joins ...**Concentration** parameter

Note that this is not the same as what happens when the

**concentration**parameter tends towards**infinity**. In the former case, all ... A**concentration**parameter of 1 (or k, the dimension of the Dirichlet distribution, by the definition used in the topic ...**Concentration**parameters occur in two kinds of distribution: In the Von Mises-Fisher distribution, and in conjunction with ... The larger the value of the**concentration**parameter, the more evenly distributed is the resulting distribution (the more it ...###### Stress **concentration**

... the maximum stress approaches

**infinity**and a stress**concentration**factor cannot therefore be used for a crack. Instead, the ... Stress**concentrations**may also occur from accidental damage such as nicks and scratches. The degree of**concentration**of a ... Several catalogs of stress**concentration**factors have been published. Perhaps most famous is Stress**Concentration**Design ... ESDU64001: Guide to stress**concentration**data. ESDU. ISBN 1-86246-279-8. Peterson, Rudolf Earl (1953). Stress**Concentration**...###### Eadie-Hofstee diagram

... approaches

**infinity**, or limiting rate, and K m {\displaystyle K_{\mathrm {m} }} is the value of a {\displaystyle a} at half- ... and not the substrate**concentration**a {\displaystyle a} , so v {\displaystyle v} is the dependent variable. As a result, both ... of an enzyme-catalysed reaction as a function of the substrate**concentration**a {\displaystyle a} is the Michaelis-Menten ...###### An **Infinity** of Mirrors

... a monocle-twirling Prussian general who cannot see the evil of Hitler until their adored child dies in a Jewish

**concentration**... An**Infinity**of Mirrors was the fifth and most ambitious book by the American satirist and political novelist Richard Condon. ... Condon's impetus for writing An**Infinity**of Mirrors is laid out in an excerpt from a letter from him that takes up the entire ... Something like this has happened to Richard Condon in An**Infinity**of Mirrors. A note on the dust jacket tells us that the ...###### Frithjof Schuon

This discernment would remain purely mental in the absence of

**concentration**on the Real through rites and prayer, i.e. without ... "A sacred work of art has a fragrance of**infinity**, an imprint of the absolute. In it individual talent is disciplined; it blends ... from dispersion to**concentration**, from egoism to detachment, from passion to serenity." The exoteric and esoteric rites of the ... mystical**concentration**and moral conformity, contains in the final analysis the only things that Heaven demands in an absolute ...###### Kemper Corporation

Indemnity Company

**Infinity**Insurance Company**Infinity**Auto Insurance Company**Infinity**Assurance Insurance Company**Infinity**... Kemper Auto is a national provider of auto insurance with a**concentration**on nonstandard auto insurance Kemper's Life & Health ...**Infinity**County Mutual Insurance Company**Infinity**Indemnity Insurance Company**Infinity**Preferred Insurance Company**Infinity**... says, Former**Infinity**IA (2018-02-20). "Kemper Corp. Acquires**Infinity**Property & Casualty of Alabama for $1.4B". Insurance ...###### Ernest Norman

The vast and staggering proportions of this great energy -

**Infinity**- cannot be assimilated in a few months or even a few years ... These malpractices include prayer,**concentration**, affirmations, certain kinds of meditation, various other forms of self- ... a new part of this great**Infinity**. This, again, is a new challenge and in proportion to his knowledge and attainment, he again ... he has somehow been made subconsciously aware of this**Infinity**. So he longs to escape from his materialistic pit of clay and ...###### Rate equation

... the initial

**concentration**of P is 0. This applies even when time t is at**infinity**; i.e., equilibrium has been reached: [ A ] e ... The**concentration**of A at time t, [ A ] t {\displaystyle [{\ce {A}}]_{t}} , is related to the**concentration**of P at time t, [ P ... For the rate proportional to a single**concentration**squared, the time dependence of the**concentration**is given by 1 [ A ] = 1 ... is the**concentration**at time t and [A]0 is the initial**concentration**at zero time. The first-order rate law is confirmed if ln ...###### Deaths in March 2018

Oskar Gröning, 96, German SS officer and war criminal, guard at Auschwitz

**concentration**camp. Warren Hawksley, 74, British ... The**Infinity**Box, Where Late the Sweet Birds Sang). Ercan Yazgan, 71, Turkish actor, multiple organ failure. Jerry Anderson, 62 ...###### Holocene extinction

Without them, our loneliness would stretch to

**infinity**.. *. Firestone RB, West A, Kennett JP, Becker L, Bunch TE, Revay ZS, et ... While a number of human-derived factors are recognized as contributing to rising atmospheric**concentrations**of CH4 (methane) ... Large populations of megaherbivores have the potential to contribute greatly to the atmospheric**concentration**of methane, which ... Another study examined the change in the methane**concentration**in the atmosphere at the end of the Pleistocene epoch after the ...###### Sediment transport

is the

**concentration**of suspended sediment at that elevation, h. {\displaystyle h}. is the flow depth, P. {\displaystyle P}. is ... by a nonlinear diffusion equation in which classic diffusion dominates for shallow slopes and erosion rates go to**infinity**as ... Turbulent mixing results in the net motion of particles from regions of high**concentrations**to low**concentrations**. Because ... This characterization works for the situation in which sediment**concentration**c. 0. {\displaystyle c_{0}}. at one particular ...###### Hasidic Judaism

... from

**Infinity**to Finitude, so it may be reversed from the state of Finite to that of**Infinity**". Kabbalah stressed the ... In Israel, the largest Hasidic**concentrations**are in the Ultra-Orthodox neighbourhoods of Jerusalem - including Ramot Alon, ... As even intellectuals struggled with the sublime dialectics of**infinity**and corporeality, there was little hope to have the ... arguing that since they linked matter with**infinity**, their abilities had to be associated with their own corporeal body. ...###### Electroencephalography

REST reference: which is an offline computational reference at

**infinity**where the potential is zero. REST (reference electrode ... busy or anxious thinking and active**concentration**. Rhythmic beta with a dominant set of frequencies is associated with various ... A method to standardize a reference of scalp EEG recordings to a point at**infinity**. Physiol. Meas. 22, 693-711. doi:10.1088/ ... non-zero reference to the new recordings with**infinity**zero as the standardized reference. A free software can be found at ( ...###### Economy of Stamford, Connecticut

Brands include AKG, Harman Kardon,

**Infinity**, JBL, Lexicon and Mark Levinson. It ranked #386 on the 2017 Fortune 500 list with ... Stamford the largest financial district in New York Metro outside New York City itself and one of the largest**concentrations**of ...###### Mediocrity principle

... and that a

**concentration**of mass such as the Solar System is an "isolated, uncommon phenomenon". He also disagrees with Richard ... David Deutsch (2011). The Beginning of**Infinity**. ISBN 978-0-14-196969-5. .. ...###### Electrical resistivity and conductivity

which is determined by the ratio of the

**concentration**of ions N. {\displaystyle N}. to the**concentration**of molecules of the ...**Infinity**(1947): ... The**concentration**of ions in the liquid depends on the degree ... ion**concentration**, α. {\displaystyle \alpha }. : the coefficient of dissociation. Superconductivity[edit]. Main article: ... The conductivity of a solution of water is highly dependent on its**concentration**of dissolved salts, and other chemical species ...###### Crystal structure

After postulating a direct correlation between electron

**concentration**and crystal structure in beta-phase alloys, Hume-Rothery ... "at**infinity**"). A plane containing a coordinate axis is translated so that it no longer contains that axis before its Miller ... demonstrates that substantial alteration of certain properties such as specific heat may be affected by small**concentrations**of ...###### Theil index

if the situation is characterized by a continuous distribution function f(k) (supported from 0 to

**infinity**) where f(k) dk is ... Free Online Calculator computes the Gini Coefficient, plots the Lorenz curve, and computes many other measures of**concentration**...###### Reincarnation

According to Jain texts, this

**infinity**of nigodas can also be found in plant tissues, root vegetables and animal bodies.[188] ... a knowledge achieved through high levels of meditative**concentration**.[56] Tibetan Buddhism discusses death, bardo (an ...###### Gini coefficient

Gini, C. (1909). "

**Concentration**and dependency ratios" (in Italian). English translation in Rivista di Politica Economica, 87 ( ... Note that this formula can be applied when there are negative values if the integration is taken from minus**infinity**to plus ... Jasso, Guillermina (1979). "On Gini's Mean Difference and Gini's Index of**Concentration**". American Sociological Review. 44 (5 ... Gini, C. (1936). "On the Measure of**Concentration**with Special Reference to Income and Statistics", Colorado College ...###### User:Farcaster

The global

**concentration**of CO2 in our atmosphere today far exceeds the natural range over the last 650,000 years of 180 to 300 ... Raise the payroll tax cap ($117,000 in 2014) to**infinity**, meaning tax all income. The Social Security actuaries estimate that ... Prevent the current dangerous**concentration**of risk from occurring again. Fannie & Freddie had $5 trillion in debt or ... "Human activity has been increasing the**concentration**of greenhouse gases in the atmosphere (mostly carbon dioxide from ...###### Biological neuron model

For GABAB, [G] is the

**concentration**of the G-protein, and Kd describes the dissociation of G in binding to the potassium gates ... it diverges to**infinity**in finite time.[10][11] FitzHugh-Nagumo[edit]. Main article: FitzHugh-Nagumo model ... y(t) is the input of the model and is interpreted as the neurotransmitter**concentration**on the cell surrounding (in most cases ... For NMDA, there is a significant effect of magnesium block that depends sigmoidally on the**concentration**of intracellular ...###### Window function

The DPSS (discrete prolate spheroidal sequence) or Slepian window maximizes the energy

**concentration**in the main lobe,[53] and ... Since the Gaussian function extends to**infinity**, it must either be truncated at the ends of the window, or itself windowed with ...###### Interferometry

2a must be observed with a telescope set at

**infinity**, while the fringes of Fig. 2b will be localized on the mirrors.[2]:17 ... A typical use would be in continual monitoring of the column**concentration**of trace gases such as ozone and carbon monoxide ...###### Ventilation/perfusion ratio

An area with ventilation but no perfusion (and thus a V/Q undefined though approaching

**infinity**) is termed dead space.[3] ... These two variables, V & Q, constitute the main determinants of the blood oxygen (O2) and carbon dioxide (CO2)**concentration**. ... at the base of the lung the ratio is lower but nearer to the optimal value for reaching adequate blood oxygen**concentrations**. ...###### Universe

In the earliest stages of the universe, tiny fluctuations within the universe's density led to

**concentrations**of dark matter ... Aristotle responded to these paradoxes by developing the notion of a potential countable**infinity**, as well as the infinitely ...###### Supermassive black hole

Fulvio Melia (2003). The Edge of

**Infinity**. Supermassive Black Holes in the Universe. Cambridge University Press. ISBN 978-0-521 ... May 1, 1978). "Dynamical evidence for a central mass**concentration**in the galaxy M87". Astrophysical Journal, Part 1. 221: 731- ... only possible with a high**concentration**of matter in the center. Currently, the only known objects that can pack enough matter ... dispersion of the stars in the nuclear region of elliptical galaxies could only be explained by a large mass**concentration**at ...###### Dauphin County, Pennsylvania

"Student Poverty

**Concentration**2012". Archived from the original on 2015-12-22. Retrieved 2016-01-05 ...**Infinity**Charter School. *Sylvan Heights Science Charter School. *Capital Area School for the Arts ...###### Usuari:Paucabot/Escala Scoville - Viquipèdia, l'enciclopèdia lliure

pebre Naga Viper,[6]

**Infinity**Chilli,[7] Bhut Jolokia chili pepper[8][9] Trinidad Scorpion Butch T pepper[10] ... This identifies and measures the**concentration**of heat-producing chemicals. The measurements are used in a mathematical formula ... Grantham's**Infinity**chilli named hottest in world». BBC News, 18-02-2011. ... no vàlida; el nom «**infinity**» està definit diverses vegades amb contingut diferent. ...###### Magnetic monopole

The case of a more general Lie group G, where the stabilizer of ϕ at

**infinity**is a maximal torus, was treated by M. K. Murray[ ... 1978). "On the**concentration**of relic monopoles in the universe". Phys. Lett. B79 (3): 239-41. Bibcode:1978PhLB...79..239Z. doi ... Restricting to gauge transformations that preserve the connection at**infinity**gives a 4k-dimensional manifold Mk, which is a ... the string just goes off to**infinity**. The string is unobservable, so you can put it anywhere, and by using two coordinate ...###### Electrical resistivity and conductivity

The conductivity of a solution of water is highly dependent on its

**concentration**of dissolved salts, and other chemical species ...**Infinity**(1947): ... dopant atoms increase the majority charge carrier**concentration**... The value of the residual resistivity of a metal is decided by its impurity**concentration**. Some materials lose all electrical ... The resistivity of ionic solutions (electrolytes) varies tremendously with**concentration**- while distilled water is almost an ...###### Atom

... and vanishes when the distance from the nucleus goes to

**infinity**, roughly in an inverse proportion to the distance. In the ... atoms have a much higher**concentration**, with the density of matter in the interstellar medium (ISM) ranging from 105 to 109 ...###### Inverse problem

Diffusing material

**concentration**as a function of space and time. Monitoring of this**concentration**measured at different ... Thus any solution of this equation is determined up to an additive function in the null-space and, in the case of**infinity**of ... In the case of a symmetric kernel, we have an**infinity**of eigenvalues and the associated eigenvectors constitute a hilbertian ... Since a finite number of data does not allow the determination of an**infinity**of unknowns, the original data misfit functional ...###### Discworld (world)

Dehydrated water is a peculiar substance found only in areas of high magical

**concentration**. It resembles fine sand, but can be ... the product of spending their lives overlooking a bottomless black abyss of**infinity**. On the Disc, the phrase "being on edge" ...###### Passage Meditation

One-pointed attention helps to unify consciousness and deepen

**concentration**. Training the mind to give full attention to one ... ISBN 978-9986-02-775-1 (236 pages) Eknath Easwaran (2008). Opt paşi spre infinit (Eight Steps to**Infinity**)(Antoaneta Goţea, ...###### Tailings

**Concentration**. *Froth flotation. *Jameson cell. *Panning. *Jig concentrators. *Gravity

**Concentration**. *Magnetic separation ( ...

###### Atom

The potential energy of an electron in an atom is negative relative to when the distance from the nucleus goes to

**infinity**; its ... Only such an intense**concentration**of charge could produce an electric field strong enough to deflect the alpha particles as ... particles have a much higher**concentration**, with the density of matter in the interstellar medium (ISM) ranging from 105 to 109 ...**Concentration**

It definitely has potential, but i feel like all the instruments are fighting to be heard and not blending as well. Choose one or two instruments to be the main focus and put everything else in the background or have come in at only certain sections. The drums could be beefed up a bit too so it gives it that jumpy feel. Just a couple things to work on to make some progress ...

###### Luxury 2 Level House **Infinity** Pool 5-min wa... - HomeAway

Luxury 2 Level House

**Infinity**Pool 5-min walk Playa Blanca #1 Beach Costa Rica. 4 bedroom house & joining New Apartment at ... Imagine a magical place where nature surrounds you; an alluring**concentration**of beauty, rainforests, beaches, landscapes, ... the**infinity**pool at the house is the coolest ever, but the beach is close and beautiful as well. You might want a golf cart ... The**infinity**pool is small, but it is really nice and unique, and the view from the pool area is great. Wade was extremely ...###### Econometrics | Free Full-Text | Decomposing the Bonferroni Inequality Index by Subgroups: Shapley Value and Balance of...

goes to

**infinity**, the quantity N. −. 1. N. goes to 1 and the Lorenz area in the case of maximum**concentration**approaches 1. /. ... goes to**infinity**, the quantity N. −. 1. N. goes to 1 and the Bonferroni area in case of maximum**concentration**is equal to 1. . ... The Gini**Concentration**Index. The Gini**concentration**ratio (Gini 1914), also referred to as the Gini coefficient or the Gini ... As the**concentration**ratio R. , the Bonferroni index B. can be completely decomposed by the sum of three terms:. B. =. B. w. + ...###### APL-501 Study for Select Advanced or Relapsed/Recurrent Solid Tumors - Full Text View - ClinicalTrials.gov

###### Carrier **Infinity** - poor performance high stage - Page 5

Carrier

**Infinity**supply air temp goes up from low to high stage, suction pressure goes up - good performance at low stage) ... Building Physics Rule #3: Higher moisture**concentration**moves toward lower moisture**concentration**. ... Building Physics Rule #3: Higher moisture**concentration**moves toward lower moisture**concentration**. ... Of course that might freak out the**Infinity**control, but it might not, given what it has been dealing with so far. Something I ...###### Effects of long DNA folding and small RNA stem-loop in thermophoresis | PNAS

the distribution of the DNA

**concentration**is. where is the DNA**concentration**at**infinity**, (no slip condition), and is the ... is the PEG**concentration**, is the PEG diffusion constant, and is the thermal diffusion constant. The PEG**concentration**gradient ... Thermophoresis depletes a PEG polymer from the hot region and builds a**concentration**gradient of PEG (5). As PEG**concentration**... Selection of stem-loop RNA in the PEG**concentration**gradient. (A) Stem-loop RNA with 12-bp stem (Upper) and ssRNA poly-U of 15 ...###### DailyMed - KEDRAB- human rabies virus immune globulin injection, solution

Abbreviations: AUC: area under the

**concentration**-time curve; Cmax: maximum**concentration**; inf:**infinity**; IU: international ... Abbreviations: AUC: area under the**concentration**-time curve; Cmax: maximum**concentration**; inf:**infinity**; IU: international ... A plot of plasma rabies virus neutralizing antibody titer**concentration**versus time (Figure 1) demonstrated that, in both ... Figure 1: Plasma HRIG**Concentrations**[Mean (±SD)] at Scheduled PK Sampling Days (Semi-log Scale), Phase 2/3 Study, ...###### These highlights do not include all the information needed to use KEDRAB safely and effectively. See full prescribing...

Abbreviations: AUC: area under the

**concentration**-time curve; Cmax: maximum**concentration**; inf:**infinity**; IU: international ... Abbreviations: AUC: area under the**concentration**-time curve; Cmax: maximum**concentration**; inf:**infinity**; IU: international ... A plot of plasma rabies virus neutralizing antibody titer**concentration**versus time (Figure 1) demonstrated that, in both ... Figure 1: Plasma HRIG**Concentrations**[Mean (±SD)] at Scheduled PK Sampling Days (Semi-log Scale), Phase 2/3 Study, ...###### The Herb-Drug Interaction of Clopidogrel and Xuesaitong Dispersible Tablet by Modulation of the Pharmacodynamics and Liver...

ng/mL): maximum plasma

**concentration**; AUC: the area under the**concentration**time curve; : from time zero to**infinity**; : from ... The lowest**concentration**at S/N ratios of 10 with the RSD ,20% was taken as LLOQ and was found to be 0.64 ng/mL for CAMD (Table ... The mean plasma**concentration**-time profiles are illustrated in Figure 3 and pharmacokinetic parameters are presented in Table 3 ... Mean plasma**concentration**-time profiles of CAMD in rats (n = 6) after continuous oral administration of clopidogrel (30 mg/kg) ...###### Patent US20030200644 - Electrochemical test strip cards that include an integral dessicant - Google Patents

The subject test strips and cards find use in the detection/

**concentration**determination of a number of different analytes, ... this**infinity**current value was termed iSS. ISS is approximately proportional to glucose**concentration**. FIGS. 5a, 5 b and 5 c ... While in principle the subject methods may be used to determine the**concentration**of an analyte in a variety of different ... The subject test strips and cards find use in the detection/**concentration**determination of a number of different analytes, ...###### Methods and compositions for pulmonary administration of a TNFa inhibitor - Li, Luk-chiu

... the area under the serum

**concentration**vs. time (AUC) by 8 hours; AUC0-∞, AUC by time**infinity**; F %0-8 hr, the absolute ... the area under the serum**concentration**vs. time (AUC) by 8 hours; AUC0-∞, AUC by time**infinity**. ... The method of any one of claims 1-8, wherein a maximum serum**concentration**(Cmax) of at least about 2.3 mg/L of the TNFα ... time curve by 8 days (AUC0-8 day) by the trapezoidal method and those by time**infinity**(AUC0-∞) from AUC0-8 day plus ...###### Take Action Now: Prioritize Your Goals, Overcome Procrastination and Take Action like a Pro with Affirmations and Hypnosis ...

Enhanced Brain Power: Improve Your Memory, Enhance

**Concentration**and Achieve Higher Mental Clarity with Hypnosis. ... Narrated by:**Infinity**Productions * Length: 1 hr and 31 mins * Unabridged * Overall ... Enhanced Brain Power: Improve Your Memory, Enhance**Concentration**and Achieve Higher Mental Clarity with Hypnosis. ... Enhanced Brain Power: Improve Your Memory, Enhance**Concentration**and Achieve Higher Mental Clarity with Hypnosis ...###### Motrin - FDA prescribing information, side effects and uses

AUCinf = Area-under-the-curve to

**infinity**. Tmax = Time-to-peak plasma**concentration**... The mean minimum lithium**concentration**increased 15% and the renal clearance of lithium was decreased by 19% during this period ... Protein binding is saturable and at**concentrations**,20 μg/mL binding is non-linear. Based on oral dosing data there is an age- ... coadministration of cimetidine or ranitidine with ibuprofen had no substantive effect on ibuprofen serum**concentrations**. ...###### Bioequivalence Study of Trifluridine and Tipiracil Tablets in Colorectal Cancer Patients - Full Text View - ClinicalTrials.gov

AUC(0-

**infinity**) [ Time Frame: 3 days ]. The AUC(0-**infinity**) is area under the serum**concentration**-time curve from time zero to ... The Cmax is observed maximum serum**concentration**, taken directly from the serum**concentration**-time profile ... The AUC(0-t) is area under the serum**concentration**-time curve from time zero to t. ... Bioequivalence based on Peak Plasma**Concentration**(Cmax) [ Time Frame: 3 days ]. ...###### Study of STRO-002, an Anti-Folate Receptor Alpha (FolRα) Antibody Drug Conjugate in Ovarian & Endometrial Cancers - Full Text...

Characterize the PK of STRO-002 measuring the total area under the

**concentration**versus time curve from zero to**infinity**( ... Measurement of AUC to**infinity**(AUC inf). *Part 2: Characterize the PK of STRO-002 by measuring the clearance (CL) [ Time Frame ... Measurement of AUC to**infinity**(AUCinf). *Part 1: Characterize the PK of STRO-002 by measuring the clearance (CL) [ Time Frame ... Measurement of maximum plasma**concentration**after the administration of STRO-002. *Part 1: Characterize the PK of STRO-002 by ...###### Patent US6569456 - Osmotic device containing diltiazem and an ACE inhibitor or diuretic - Google Patents

AUC0-inf indicates the AUC0-t extrapolated to

**infinity**. Cmax indicates the maximum plasma**concentration**of the drug. Tmax ... The data represents the mean plasma**concentration**of diltiazem. The observed plasma**concentration**profile of FIG. 7 can be ... Solute**concentration**measurement device and related methods. US8685451. Jun 18, 2008. Apr 1, 2014. Osmotica Kereskedelmi s ... 7 depicts the in vivo plasma**concentration**profile provided by a single dose of the osmotic device of Example 1. ...###### Arymo ER - FDA prescribing information, side effects and uses

... time to achieve the maximum observed plasma

**concentration**; AUC0-∞ = area under the curve, zero to**infinity**; SD=standard ... Cmax = maximum observed plasma**concentration**; Tmax = time to achieve the maximum observed plasma**concentration**; AUC0-∞ = area ...**Concentration**-Adverse Reaction Relationships. There is a relationship between increasing morphine plasma**concentration**and ...**Concentration**-Efficacy Relationships. The minimum effective analgesic**concentration**will vary widely among patients, especially ...###### Accretropin (Somatropin Injection): Side Effects, Interactions, Warning, Dosage & Uses

... maximum

**concentration**; t½=half-life; Tmax=time to maximum**concentration**(given as the median value with range); SD=standard ... Abbreviations: AUC0-t=area under the curve until 24 hours after administration; AUC0-inf=area under the curve to**infinity**; Cmax ...**Concentrations**of IGF-1, which may play a role in skeletal growth, are low in the serum of growth hormone-deficient pediatric ... Serum**concentrations**of inorganic phosphate increased in patients with growth hormone deficiency after therapy with human ...###### Diffusion-thermo and thermal-diffusion effects on free convective heat and mass transfer flow in a porous medium with time...

... effects on free convective heat and mass transfer flow in a porous medium with time dependent temperature and

**concentration**.( ... Initially the plate and the fluid are at same temperature [T.sub.[**infinity**]] in a stationary condition with**concentration**level ...**infinity**]] = [[eta].sub.[**infinity**]] + [DELTA][eta]. The maximum value of [[eta].sub.[**infinity**]], to each group of parameters [v ... C =**concentration**[c.sub.p] = specific heat at constant pressure [c.sub.s]=**concentration**susceptibility [D.sub.m] = mass ...###### Rapidly separable microneedle patch for the sustained release of a contraceptive | Nature Biomedical Engineering

... and maintained plasma

**concentrations**of the hormone above the human therapeutic level for one month. Further development of the ... Rats administered LNG-loaded microneedle patches exhibited LNG plasma**concentrations**that increased to a peak**concentration**(C ... and the AUC from time zero to**infinity**(AUC0-inf). The bioavailability of LNG delivered from the microneedles was calculated ... These parameters included: the observed maximum plasma**concentration**(Cmax); the time when Cmax was achieved (Tmax); the ...###### LUKAS CRYL Studio Artists Paint High Pigment **Concentration** - 500 ml Bottle Green Earth - Educational Toys Planet

Black

**Infinity**Cube By Duddy Pro Desk Toy For Focus And**Concentration**Premium Spinner Abs. 10.77 ... LUKAS CRYL Studio Artists Paint High Pigment**Concentration**- 500 ml Bottle Green Earth. Item number etp-ex-B0012FE6ES ... Janod Pure Fox Bead Maze Wooden Looped Activity Center Learning Toy for Boys & Girls - Counting**Concentration**Shape Recognition ... LUKAS CRYL Studio Artists Paint High Pigment**Concentration**- 500 ml Bottle Green Earth. 15.59 ...###### Burning carbon particle -- Boundary conditions | Physics Forums - The Fusion of Science and Community

###### Martin Lopez - Wikipedia

###### Plus it

Glucose

**concentration**was measured using**Infinity**Glucose Reagent (ThermoElectron). For Nile Red staining, whole flies or ... Measurement of intracellular free amino acid**concentration**.. Protein**concentrations**of plasma mixed with 5% trichloroacetic ... reduced expression of genes important in the intracellular**concentration**of amino acids, and thereby, reduced**concentration**of ... Free amino acid**concentrations**of the samples were analyzed using a Hitachi l-8800 amino acid analyzer (25). ...###### Complex Reactions: Equilibria - Chemical Kinetics II | Coursera

time

**infinity**, divided by the**concentration**of A at time**infinity**.. So we can just take this term here, divide it by this term ... We can easily also get the**concentration**of B at**infinity**.. Because if you remember the**concentration**of A plus B must at any ... So, therefore, we can also write that the total**concentration**. of A at any given time + the**concentration**of B at any given ... So from these two**concentrations**which weve worked out now at time**infinity**, ...###### Plus it

Glucose

**concentrations**were measured using an oxidase-peroxidase assay (Sigma-Aldrich). Serum triglycerides (TGs), cholesterol ...**Infinity**TG or cholesterol kit; Thermo Fisher Scientific, Waltham, MA), and free fatty acid (FFA) (NEFA-HR [2]; Wako ... to a final**concentration**of 60 mg/kg. For the normal dox diet, a 600 mg/kg diet (S4107; Bio-Serv, Flemington, NJ) was used. All ...###### Metabolism and Disposition of Resveratrol in Rats: Extent of Absorption, Glucuronidation, and Enterohepatic Recirculation...

area under the curve extrapolated to

**infinity**. CL. clearance. CL/F. oral clearance. CL/Fm. apparent clearance of metabolite. C ... maximum observed plasma**concentration**. %ER. percentage of the exposure due to enterohepatic recirculation. ESI-LC/MS/MS. ... time of maximum observed plasma**concentration**. Varea/F. apparent volume of distribution after oral administration. Varea/Fm. ... followed by sudden increases in plasma**concentrations**4 to 8 h after drug administration. These plasma**concentrations**resulted ...###### uhplc-analysis-drugs-glucuronidase | China-Mainland | Sigma-Aldrich

... final

**concentration**100 ng/mL; system: Agilent 1290**Infinity**with Agilent 6210 TOF ... Table 2. β-Glucuronidase, Sources, Forms, and**Concentrations**. Product. No.. Source. Form. Stock.**Concentration**. Final ... Analyte**concentration**in urine: 200 ng/mL. Solid Phase Extraction (SPE) Method. SPE removes excess enzyme that can interfere ... β-Glucuronidase**concentration**: 10 kU/mL and 50 kU/mL. Incubation Time. A rapid conversion of the glucuronide metabolite to the ...###### UHPLC/MS of Drugs and Metabolites in Urine following Enzymatic Hydrolysis | Sigma-Aldrich

... and enzyme

**concentration**must be evaluated for each glucuronide metabolite to be analyzed. ... final**concentration**100 ng/mL; system: Agilent 1290**Infinity**with Agilent 6210 TOF ... Table 2. β-Glucuronidase, Sources, Forms, and**Concentrations**. Product. No.. Source. Form. Stock.**Concentration**. Final ... Analyte**concentration**in urine: 200 ng/mL. Solid Phase Extraction (SPE) Method. SPE removes excess enzyme that can interfere ...###### The Genealogical Consequences of Fecundity Variance Polymorphism | Genetics

do not even have a limit as N tends to

**infinity**. On the other hand, if we let n(t) = n1(t) + n2(t) denote the total number of ... Second, the**concentration**of p′ around p also implies that the conditional expectation of the random variable given p tends to ... Under these conditions, Gillespie (1975) showed that if time is measured in units of N generations, then as N tends to**infinity**... The next task is to evaluate the limit, as N tends to**infinity**, of the conditional expectation in the last line of (3). This ...PharmacokineticConfidence intervalSerumPlasma concentration-time curveMetabolitesTandem mass spectrometry mParametersPharmacologicalIntracellular freeTimeReactantsRenal clearanceUrinaryIncreasesDisplaystylePeak plasma concentrationGlucoseConstantsZero to infinityProportionalEliminationMaximum concentrationDoseUrineAdministrationInitial concentrationIntermediateReactionAcid DissociaSpeciesHighAreaEquilibriumBloodDetectionLowerLiquidConstantHigherMeditationRangePhaseGradient

###### Pharmacokinetic3

- Bioquivalence of generic and branded products is based on two key pharmacokinetic (PK) measures: area under the concentration- time curve (AUC) and maximal concentration (C max ) ( US Food and Drug Administration ). (frontiersin.org)
- Data from concentration-time curves allowed us to establish the main pharmacokinetic parameters in two models: one- and/or two-compartment. (mdpi.com)
- 0.05) were observed between both formulations for any of the pharmacokinetic parameters evaluated and plasma ropivacaine concentrations, considering each period of time. (scielo.br)

###### Confidence interval2

- 95 percent confidence interval, 4.7 to infinity). (nih.gov)
- The 90% confidence interval for the geometric mean ratio of maximum concentration, area under the concentration-time curve from 0 to interval t, and area under the concentration-time curve from 0 to infinity were within the range of 80-125% for both fexofenadine and montelukast in the test and reference products, indicating bioequivalence between the fixed dose combination and individual components. (ijpsonline.com)

###### Serum7

- 12. The method of any one of claims 1- 8 , wherein a maximum serum concentration (C max ) of at least about 2.3 mg/L of the TNFα inhibitor is achieved. (freepatentsonline.com)
- H-2 Antagonists - In studies with human volunteers, coadministration of cimetidine or ranitidine with ibuprofen had no substantive effect on ibuprofen serum concentrations. (drugs.com)
- The primary PK parameters, maximum observed concentration (C max ) and area under the curve extrapolated to infinity (AUC inf ), were calculated with the serum erythropoietin (EPO) concentrations from blood samples collected for 144 h after dosing. (dovepress.com)
- The serum EPO concentration and the reticulocyte count were used to assess the concentration-response relationship. (dovepress.com)
- The time-matched serum EPO concentration and PD markers presented a counterclockwise hysteresis, suggesting a time delay between the measured concentration and the response. (dovepress.com)
- Furthermore, both formulations had a similar time-matched serum EPO concentration and erythropoietic response profile. (dovepress.com)
- The surgeon was positive for hepatitis B e antigen and had a high serum HBV DNA concentration (15 ng per milliliter). (nih.gov)

###### Plasma concentration-time curve2

- The area under the plasma concentration-time curve from zero to infinity (AUC 0-∞ ) increases disproportionally after increased single oral doses of DTZ. (aspetjournals.org)
- After 7 days, a twofold increase in CBD dose resulted in 1.6- and 1.9-fold increases in geometric mean C max and area under the plasma concentration-time curve over a dosing interval (AUC τ ), respectively. (springer.com)

###### Metabolites2

- Variables such as β-glucuronidase enzyme concentration, digestion pH, incubation time, and temperature all play important roles for effective hydrolysis of glucuronide metabolites. (sigmaaldrich.com)
- Plasma concentrations of cerivastatin, its metabolites, and gemfibrozil were measured up to 24 hours. (nih.gov)

###### Tandem mass spectrometry m2

- Multiple plasma and urine samples were collected and concentrations of RES AGL and RES GLU were determined using an electrospray ionization-liquid chromatography/tandem mass spectrometry method. (aspetjournals.org)
- Lotilaner blood concentrations were measured using a validated liquid chromatography/tandem mass spectrometry method. (springer.com)

###### Parameters1

- The rate law or rate equation for a chemical reaction is an equation that links the reaction rate with the concentrations or pressures of the reactants and constant parameters (normally rate coefficients and partial reaction orders). (wikipedia.org)

###### Pharmacological1

- However, results from these experiments may be confounded because administration of glucocorticoids typically elevates plasma concentrations to maximal or even pharmacological levels (e.g. (biologists.org)

###### Intracellular free1

- The authors conclude that NPs--at concentrations below those required to cause formation of intracellular free radicals--caused concentration-dependent alterations in neuronal network activity. (thefreedictionary.com)

###### Time14

- Mean residence time (MRT) at last measurable concentration (MRTlast). (clinicaltrials.gov)
- Compared to control, plasma concentration-time profile in CCl 4 -treated and, to a lesser extent, in cisplatin-treated rats decreased more slowly particularly in the elimination phase. (hindawi.com)
- Diffusion-thermo and thermal-diffusion effects on free convective heat and mass transfer flow in a porous medium with time dependent temperature and concentration. (thefreelibrary.com)
- The diffusion-thermo and thermal-diffusion effects on unsteady free convection and mass transfer flow along an accelerated vertical porous plate embedded in a porous medium have been studied numerically taking the plate temperature and concentration to be functions of time. (thefreelibrary.com)
- Prediction of the extent and time course of drug-drug interactions (DDIs) between the mechanism-based inhibitor diltiazem (DTZ) and the CYP3A4 substrate midazolam (MDZ) is confounded by time- and concentration-dependent clearance of the inhibitor. (aspetjournals.org)
- However, despite several successful predictions, these approaches either do not address the change in inhibitor concentration with time or do not consider the interaction at the gut wall. (aspetjournals.org)
- The mean EPO concentration-time profiles were comparable between the two formulations. (dovepress.com)
- In control-treated monkeys ( Cercopithecus aethiops ), the in vivo CZN area under the curve extrapolated to infinity (AUC inf ) was 19.7 ± 4.5 μg μ h/ml, t 1/2 was 0.57 ± 0.07 h, and terminal disposition rate constant calculated from last three to four points on the log-linear end of the concentration versus time curve was 1.2 ± 0.2 /h. (aspetjournals.org)
- For signal attenuation and concentration determination corneas were saturated and measured a second time by two-photon microscopy. (arvojournals.org)
- time to maximum plasma concentration ( t max ) was approximately 4-5 h. (springer.com)
- Box plot of the area under the concentration-time curve from time zero to infinity (AUC 0-∞ ) of telavancin in obese and nonobese subjects after a single weight-stratified fixed dose of 500 mg, 750 mg, or 1,000 mg. (asm.org)
- Visual predictive check (VPC) plot displaying the observed telavancin concentrations (open circles) and the 5th (bottom dashed line), 50th (solid line), and 95th (top dashed line) percentile telavancin plasma concentrations versus time simulated from the final covariate model. (asm.org)
- There are a lot of valid reasons not to like what that equation says, the principal one, in my view, being that the emissions and concentration record we have is too short to enable us to infer such a long time constant. (wattsupwiththat.com)
- Within 4 to 5 h they fell to about 30 to 55% of the C max , and thereafter a terminal half-life of 11 to 14 h accounted for the major part of the area under the concentration-time curve (AUC). (asm.org)

###### Reactants2

- This predicts that the rate depends only on the concentrations of the reactants, raised to the powers of their stoichiometric coefficients. (wikipedia.org)
- Reactants and products are formed at such a rate that the concentration of neither changes. (wikipedia.org)

###### Renal clearance1

- At steady-state concentration, renal clearance of this drug is 1.02 L/h [ 6 ] and its elimination half-life (T1/2) varies from 20 to 30 h [ 5 ]. (hindawi.com)

###### Urinary2

- Plasma and urinary concentrations were determined using validated analytical methods. (frontiersin.org)
- Sglt2 −/− mice had glucosuria, polyuria, and increased food and fluid intake without differences in plasma glucose concentrations, GFR, or urinary excretion of other proximal tubular substrates (including amino acids) compared with WT mice. (asnjournals.org)

###### Increases3

- After i.v. administration, plasma concentrations of RES AGL declined with a rapid elimination half-life ( T 1/2 , 0.13 h), followed by sudden increases in plasma concentrations 4 to 8 h after drug administration. (aspetjournals.org)
- RES AGL and RES GLU also displayed sudden increases in plasma concentrations 4 to 8 h after oral administration, with T 1/2TER of 1.48 and 1.58 h, respectively. (aspetjournals.org)
- Gemfibrozil greatly increases plasma concentrations of cerivastatin, cerivastatin lactone, and metabolite M-1, whereas the level of metabolite M-23 is markedly reduced by gemfibrozil. (nih.gov)

###### Displaystyle1

- This relationship is written as c = K P {\displaystyle c=KP\,} where k is a temperature-dependent constant, p is the partial pressure, and c is the concentration of the dissolved gas in the liquid. (wikipedia.org)

###### Peak plasma concentration2

- Peak plasma concentration is reached within 1-4 h after administration [ 5 ]. (hindawi.com)
- The peak plasma concentration of topotecan was 12.82 ± 8.55 μg/mL with a plasma half-life of 6.17 ± 2.75 hours. (aacrjournals.org)

###### Glucose4

- The subject test strips and cards find use in the detection/concentration determination of a number of different analytes, including glucose. (google.com)
- There was a tendency towards lower blood glucose concentrations after repaglinide administration in the participants with the c.521CC genotype than in those with the c.521TT genotype. (nih.gov)
- Glucose in urine, however, is absent or at very low concentrations in healthy adults (range 0.03 to 0.30 g/d) as a result of near complete reabsorption along the nephron segments, primarily in the proximal tubule. (asnjournals.org)
- The concept has been developed that the low-affinity/high-capacity Na + -glucose co-transporter SGLT2 ( Slc5a2 ) mediates the bulk uptake of glucose across the apical membrane of the early proximal tubule, whereas the high-affinity/low-capacity SGLT1 ( Slc5a1 ) reduces luminal glucose concentrations to very low concentrations in further distal parts of the proximal tubule. (asnjournals.org)

###### Constants1

- Equilibria involving the formation of chemical complexes are also dynamic equilibria and concentrations are governed by the stability constants of complexes. (wikipedia.org)

###### Zero to infinity1

- The analysis of the AUC were calculated directly in the range of zero to infinity on the basis of Quadrature Gauss-Laguerre. (usp.br)

###### Proportional3

- the rate is going to be proportional to the concentration of A. (coursera.org)
- It's going to be proportional to the concentration of B. (coursera.org)
- In this case, the equilibrium concentration of CO2 in the liquid is given by Henry's law, which states that the solubility of a gas in a liquid is directly proportional to the partial pressure of that gas above the liquid. (wikipedia.org)

###### Elimination1

- These plasma concentrations resulted in a significant prolongation of the terminal elimination half-life of RES AGL ( T 1/2TER , 1.31 h). (aspetjournals.org)

###### Maximum concentration1

- The primary PK endpoints were area under the curve (AUC), extrapolated to infinity (AUC 0-∞ ), and maximum concentration ( C max ). (nih.gov)

###### Dose2

- Plasma concentrations of sildenafil and N -desmethylsildenafil were determined up to 24 hours post dose by use of liquid chromatography-tandem mass spectrometry (limit of quantification, 1 ng/ml). (anabolicminds.com)
- The mean maximum concentrations of moxifloxacin in plasma ( C max ) ranged from 0.29 mg/liter (50-mg dose) to 4.73 mg/liter (800-mg dose) and were reached 0.5 to 4 h following drug administration. (asm.org)

###### Urine1

- The concentrations of moxifloxacin in plasma, urine, and saliva were determined by a validated high-pressure liquid chromatography assay with fluorescence detection. (asm.org)

###### Administration4

- Peak plasma concentrations are about 2-4 hours after administration. (anabolicminds.com)
- Following oral administration in fed cats, lotilaner was readily absorbed and peak blood concentrations reached within four hours. (springer.com)
- Following oral administration to fed dogs, lotilaner displayed a terminal half-life (T 1/2z ) of 30.7 days and maximum blood concentrations were reached within two hours. (springer.com)
- Following the iv administration of [14C]DMP.lactate (2.5 mg/kg), plasma concentrations of DMP declined in a biexponential manner and were measurable to 48 hr. (biomedsearch.com)

###### Initial concentration2

- we let the initial concentration of A be A 0. (coursera.org)
- to be equal to the initial concentration of A ions. (coursera.org)

###### Intermediate2

- The equation may involve a fractional order , and may depend on the concentration of an intermediate species. (wikipedia.org)
- corticosterone levels in migratory birds generally circulate at intermediate concentrations (e.g. (biologists.org)

###### Reaction3

- where [A] and [B] express the concentration of the species A and B (usually in moles per liter ( molarity , M)). The exponents x and y are the partial orders of reaction for A and B and the overall reaction order is the sum of the exponents. (wikipedia.org)
- As the equilibrium constant approaches infinity, the reaction tends to form 100% products. (wikibooks.org)
- The concentration of water during the reaction is, therefore, a constant, and can be excluded from the expression for K. This gives rise to a special equilibrium constant, K a , known as the acid dissociation constant . (wikibooks.org)

###### Acid Dissocia1

- Like the acid dissociation constant, it is defined as the equilibrium constant multiplied by the concentration of water. (wikibooks.org)

###### Species1

- This equilibrium can be used to calculate the concentrations of species in the solution. (wikibooks.org)

###### High3

- but there are pockets where the groundwater contains high concentrations of fluoride due to the dissolution of minerals in the local granite . (fluoridealert.org)
- This surprisingly short diffusional distance cannot be explained by a random distribution of Ca 2+ channels and renders the activation of BKChs insensitive to the relatively high concentrations of endogenous Ca 2+ buffers in hippocampal neurons. (jneurosci.org)
- Eventually you will reach a high state of concentration with all of the five hindrances gone from your mind. (dhammawiki.com)

###### Area1

- 4 Lrg Private bathrooms, 2 Level home Fully furnished with Private Infinity Pool off our terrace, 70' TV and two additional TVs, Plus social area 2 large decks overlooking the Pacific Ocean. (homeaway.com)

###### Equilibrium2

- Because the equilibrium is used for calculating the concentrations of weak acids, very little water actually reacts. (wikibooks.org)
- By the Le Chatelier Principle, we can see that if the hydronium ion concentration is increased (by adding an acid), the equilibrium will move to the left and there will be a lower concentration of hydroxide. (wikibooks.org)

###### Blood2

- Blood samples for plasma NI-0101 concentrations. (clinicaltrials.gov)
- Blood was drawn immediately before and at regular intervals after infusions for cycles 1 and 2 to determine docetaxel and ramucirumab concentrations. (omicsonline.org)

###### Detection1

- HPLC with UV detection was used to quantify plasma ropivacaine concentrations. (scielo.br)

###### Lower2

- Consistent with the phenotypic similarities, Atf4 null mice have reduced expression of genes that regulate intracellular amino acid concentrations and lower intracellular concentration of amino acids, a key TOR input. (diabetesjournals.org)
- however, plasma renin concentrations were modestly higher and plasma aldosterone levels were lower in Sglt2 −/− mice. (asnjournals.org)

###### Liquid2

- In a new bottle of soda, the concentration of carbon dioxide in the liquid phase has a particular value. (wikipedia.org)
- The concentration of carbon dioxide in the liquid has decreased and the drink has lost some of it fizzes. (wikipedia.org)

###### Constant2

- Because it simplifies to the product of hydronium and hydroxide concentration, it is sometimes called the ion product constant. (wikibooks.org)
- A nearly constant concentration could be determined over the first 75 μm. (arvojournals.org)

###### Higher2

- The active extract obtained from G. glauca contains a third compound known as galphimine-E (G-E). Although G-E is not active, it is present at a higher concentrations in G. glauca [ 6 ]. (mdpi.com)
- The amount of concentration and love for her child places her into a higher plane of being, to a state of jhana. (dhammawiki.com)

###### Meditation2

- To reach the jhanic states of the four jhanas and the five immaterial, formless realms, one must choose a meditation subject and use one-pointedness concentration. (dhammawiki.com)
- If you block sensory inputs to this region, as you do during the intense concentration of meditation, you prevent the brain from forming the distinction between self and not-self," says Newberg. (wikipedia.org)

###### Range1

- 95% of the population must have sufficient concentrations to achieve cure across a range of parasite sensitivities and baseline parasitaemia levels. (biomedcentral.com)

###### Phase1

- Infinity Provides Update on Phase 2 Signal-Finding Clinical Study of IPI-504 in Advanced Prostate Cancer," Infinity Pharmaceuticals, Inc. Press Release, Jul. (freepatentsonline.com)

###### Gradient2

- In an aqueous solution, a PEG polymer suspension is depleted from the hot region and builds a concentration gradient. (pnas.org)
- To determine the riboflavin concentration gradient in the anterior corneal stroma when using the Dresden protocol with different dextran solutions. (arvojournals.org)