Infectious bursal disease virus
Bursa of Fabricius
Poultry Diseases
Chickens
Viral Structural Proteins
Reoviridae
Birnaviridae
Viral Vaccines
Specific Pathogen-Free Organisms
Chick Embryo
Newcastle disease virus
Virus Replication
Virus Assembly
RNA, Double-Stranded
Foot-and-Mouth Disease Virus
Molecular Sequence Data
Virulence
Borna disease virus
Baculoviridae
RNA Replicase
Amino Acid Sequence
Cercopithecus aethiops
Adaptation of very virulent infectious bursal disease virus to chicken embryonic fibroblasts by site-directed mutagenesis of residues 279 and 284 of viral coat protein VP2. (1/188)
The full-length RNA genomes of a chicken embryonic fibroblast (CEF)-nonpermissive, very virulent infectious bursal disease virus (IBDV) (strain HK46) were amplified into cDNAs by reverse transcription-PCR. The full-length cDNAs were sequenced and subcloned into a eukaryotic expression vector, from which point mutations were introduced into the VP2 region by site-directed mutagenesis. The wild-type and mutated plasmids were transfected directly into CEFs to examine their ability to generate CEF-permissive recombinant viruses. Substitution of amino acid residues 279 (Asp-->Asn) and 284 (Ala-->Thr) of the VP2 protein yielded a recombinant virus which was able to be passaged in CEFs, whereas the wild-type cDNAs and an amino acid substitution at residue 330 (Ser-->Arg) of the VP2 protein alone did not yield viable virus. The results indicated that mutation of other viral proteins, including VP1, VP3, VP4, and VP5, was not required for CEF adaptation of the virus. The same approach may be used to produce CEF-adapted strains from newly evolved IBDVs or to manipulate the antigenicity of the virus. (+info)Lysis of myelocytes in chickens infected with infectious bursal disease virus. (2/188)
In specific-pathogen-free chickens infected with the highly virulent HPS-2 strain or virulent reference GBF-1 strain of infectious bursal disease virus (IBDV), pathologic changes of the bone marrow were investigated. On histologic examination, bone marrow lesions were prominent in the HPS-2 group but only mild in the GBF-1 group. The bone marrow of the HPS-2 group showed severe lysis and depletion of heterophil myelocytes with pyknotic nuclear alteration 2-3 days after inoculation. On examination with an electron microscope, heterophil myelocytes were characterized by shrinkage of the cytoplasm and peripheral condensation of nuclear chromatin. IBDV particles were not detected in altered myelocytes. A terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick end-labeling method demonstrated a positive reaction in only heterophil myelocytes. In contrast, nucleosomal DNA fragmentation in HPS-2-infected bone marrow cells was indiscernible by agarose gel electrophoresis. These findings indicate that lysis of bone marrow cells is selectively induced in heterophil myelocytes at an early stage after IBDV infection and independent of virus replication. (+info)Protection of chickens against very virulent infectious bursal disease virus (IBDV) and Marek's disease virus (MDV) with a recombinant MDV expressing IBDV VP2. (3/188)
To develop a herpes virus vaccine that can induce immunity for an extended period, a recombinant Marek's disease (MD) virus (MDV) CVI-988 strain expressing infectious bursal disease virus (IBDV) host-protective antigen VP2 at the US2 site (rMDV) was developed under the control of an SV40 early promoter. Chickens vaccinated with the rMDV showed no clinical signs and no mortality and 55% of the chickens were considered protected histopathologically after challenge with very virulent IBDV (vvIBDV), whereas all of the chickens vaccinated with the conventional IBDV vaccine showed no clinical signs and were protected. Chickens vaccinated with the CVI-988 or chickens in the challenge control showed severe clinical signs and high mortality (70-75%) and none of them were protected. Also, the rMDV conferred full protection to chickens against vvMDV just as the CVI-988 strain did, whereas 90% of the challenge control chickens died of MD. Antibody levels against IBDV and MDV following the vaccination increased continuously for at least 10 weeks. No histopathological lesions in the rMDV-vaccinated chickens and no contact transmission of the rMDV to their penmates were confirmed. These results demonstrate that an effective and safe recombinant herpesvirus-based IBD vaccine could be constructed by expressing the VP2 antigen at the US2 site of the CVI-988 vaccine strain. (+info)Sequence comparison of the VP2 variable region of infectious bursal disease virus isolates from Vietnam. (4/188)
The variable region in the VP2 gene of twenty-three infectious bursal disease virus (IBDV) isolates, collected in Vietnam in 1997 and 1998, was amplified as cDNA by using the reverse transcription-polymerase chain reaction and sequenced. Analysis of amino acid substitutions and phylogenetic relationships of the deduced amino acid sequences (residues 206-350) showed that the nineteen Vietnamese vv IBDVs clustered with the European vv IBDVs, Japanese vv IBDVs and Chinese vv strains, and that the four vietnamese virulent strains were closely related to European virulent strain 52/70. These results suggest that Vietnamese vv IBDVs, European vv IBDVs, Japanese vv IBDVs and Chinese vv strains have the same origin. (+info)VP1, the putative RNA-dependent RNA polymerase of infectious bursal disease virus, forms complexes with the capsid protein VP3, leading to efficient encapsidation into virus-like particles. (5/188)
A cDNA corresponding to the coding region of VP1, the putative RNA-dependent RNA polymerase, of infectious bursal disease virus (IBDV) was cloned and inserted into the genome of a vaccinia virus inducible expression vector. The molecular mass and antigenic reactivity of VP1 expressed in mammalian cells are identical to those of its counterpart expressed in IBDV-infected cells. The results presented here demonstrate that VP1 is efficiently incorporated into IBDV virus-like particles (VLPs) produced in mammalian cells coexpressing the IBDV polyprotein and VP1. Incorporation of VP1 into VLPs requires neither the presence of IBDV RNAs nor that of the nonstructural polypeptide VP5. Immunofluorescence, confocal laser scanning microscopy, and immunoprecipitation analyses conclusively showed that VP1 forms complexes with the structural polypeptide VP3. Formation of VP1-VP3 complexes is likely to be a key step for the morphogenesis of IBDV particles. (+info)Effect of thymus extract on immunologic reactivity of chicken vaccinated with infectious bursal disease virus. (6/188)
The effects of crude thymus extract on the immune response and protection against challenge with virulent infectious bursal disease virus (IBDV) were studied in one-day-old chick. Oral administration of thymus extract (1 ml/kg) markedly and significantly increased the total protein, albumin, globulin, Tri-iodothyronine (T3), Thyroxine (T4) and the body weight gain in one-day-old chick. In addition, it increased the total lymphocytic count over four weeks after administration. Although vaccination also increased total protein, globulin, T4 and the total lymphocytic count but it significantly decreased the body weight gain of the chick and administration of thymus extract, before, during or after vaccination markedly improved the vaccination effectiveness with significant elevation of the globulin level and body weight gain of the chick. It also prevented the decrease in the relative weights of bursa, spleen and thyroid gland which commonly prevailed during vaccination. Chicken administered thymus extract and vaccinated with infectious bursal disease (IBD) vaccine showed 100% protection against challenge with IBDV. Meanwhile the vaccinated non-thymus treated group exhibited 80% protection against IBDV challenge. These results indicate a potentiating effect of thymus extract on the immune system in baby chick. These findings are supported by ELISA results that showed a marked increase in antibody titers in thymus treated groups. Additionally, microscopical examination of the bursa and the existent lymphoid hyperplasia in thymus treated groups but not vaccinated group support our findings. (+info)Tissue culture infectivity of different strains of infectious bursal disease virus is determined by distinct amino acids in VP2. (7/188)
Two types of strains of serotype I of infectious bursal disease virus (IBDV) have been described, on the basis of their ability (IBDV-TC) or inability (IBDV-BU) to infect chicken embryonic cells in culture. However, both types infect B lymphocytes in the bursa of Fabricius of young chickens. To determine the molecular basis for tissue culture infectivity, virus recombinants with chimeric segments A were constructed from IBDV-TC and IBDV-BU by reverse genetics. The region responsible for the different phenotypes was located in VP2. Site-directed mutagenesis identified single amino acids that are responsible for the restriction in infectivity. However, the appropriate amino acid exchanges are strain-specific. (+info)Proteolytic processing in infectious bursal disease virus: identification of the polyprotein cleavage sites by site-directed mutagenesis. (8/188)
The infectious bursal disease virus (IBDV), a member of the Birnaviridae family, is the causative agent of an immune depressive disease that affects domesticated and wild avian species. The expression strategy of IBDV includes the synthesis of a 110-kDa polyprotein containing the capsid precursor polypeptides. The polyprotein is autocatalitically processed rendering three polypeptides: NH2-VPX-VP4-VP3-COOH. We have carried out a systematic analysis, using a series of plasmids encoding polyproteins containing either deletions or single amino acid substitutions, to identify the processing sites. The results obtained showed the existence of two sites, 511LAA513 and 754MAA756, that are essential for the processing of the VPX-VP4 and VP4-VP3 precursors, respectively. These sequences are highly conserved among IBDV strains form serotypes 1 and 2. A secondary VPX-VP4 processing site was detected in a 19-amino acid stretch located upstream of the 511LAA513 site. Analyses using versions of the 754MAA756 VP4-VP3 processing site containing conservative and nonconservative amino acid substitutions demonstrated that the specificity of the cleavage is dictated by the conserved AA dipeptide. (+info)Example sentences:
1. The outbreak of birnaviridae infections in the local wildlife population has been linked to the consumption of contaminated water sources.
2. The researchers are studying the effects of birnaviridae infections on the reproduction rates of infected birds.
3. The veterinarian suspects that the sudden death of several zoo animals may be due to birnaviridae infections.
Some common poultry diseases include:
1. Avian influenza (bird flu): A highly contagious viral disease that affects birds and can be transmitted to humans.
2. Newcastle disease: A viral disease that causes respiratory and gastrointestinal symptoms in birds.
3. Infectious bronchitis: A viral disease that causes respiratory symptoms in birds.
4. Marek's disease: A viral disease that affects the nervous system of birds.
5. Coccidiosis: A parasitic disease caused by the Eimeria protozoa, which can cause diarrhea and weight loss in birds.
6. Chicken anemia virus: A viral disease that causes anemia and weakened immune systems in chickens.
7. Fowl pox: A viral disease that causes skin lesions and other symptoms in birds.
8. Avian encephalomyelitis (AE): A viral disease that affects the brain and spinal cord of birds, causing neurological symptoms such as paralysis and death.
9. Mycoplasmosis: A bacterial disease caused by the Mycoplasma bacteria, which can cause respiratory and other symptoms in birds.
10. Aspergillosis: A fungal disease that affects the respiratory system of birds, causing symptoms such as coughing and difficulty breathing.
Poultry diseases can have a significant impact on bird health and productivity, and can also be transmitted to humans in some cases. It is important for poultry farmers and owners to monitor their flocks closely and take steps to prevent the spread of disease, such as providing clean water and feed, maintaining good hygiene, and vaccinating birds against certain diseases.
The common types of reoviridae infections include:
1. Rotavirus infection: This is the most common cause of diarrhea in children under five years old worldwide. It can lead to dehydration, hospitalization, and even death in severe cases.
2. Calicivirus infection: This virus is responsible for norovirus, which is the leading cause of gastroenteritis outbreaks in the United States and other countries. It can cause symptoms such as diarrhea, vomiting, and stomach cramps.
3. Aichivirus infection: This virus was first identified in 2013 and has been linked to outbreaks of gastroenteritis in the United States and Europe. The symptoms of this infection are similar to those caused by norovirus.
4. Cysticercosis: This is a parasitic infection that occurs when the larvae of the pork tapeworm (Taenia solium) infect the human brain, eyes, or muscles. It can cause symptoms such as seizures, headaches, and vision problems.
5. Orbivirus infection: This virus is responsible for diseases such as bluetongue and epizootic hemorrhagic fever, which affects animals such as sheep, goats, and cattle. It can also be transmitted to humans through the bite of an infected midge insect.
Reoviridae infections are usually diagnosed based on symptoms, medical history, and laboratory tests such as PCR (polymerase chain reaction) or ELISA (enzyme-linked immunosorbent assay). Treatment of these infections depends on the specific type of virus and the severity of the symptoms.
Prevention measures for Reoviridae infections include good hygiene practices such as washing hands regularly, cooking food thoroughly, and avoiding close contact with people who are sick. Vaccines are also available for some types of Reoviridae infections, such as the rotavirus vaccine that is given to infants to protect against gastroenteritis.
Infectious bursal disease
Drosophila X virus
Avibirnavirus
Double-stranded RNA viruses
Cattle egret
Western cattle egret
Avian immune system
Gumboro, Delaware
VDAC2
VDAC1
Avian orthoreovirus
ATCvet code QI01
List of MeSH codes (B04)
Alphitobius diaperinus
Vaccine resistance
Avian infectious bronchitis
Poultry disease
IBD
Bursa of Fabricius
Specific-pathogen-free
Gyrovirus
Avian influenza
Transporter Classification Database
The in vivo and in vitro effects of chicken interferon alpha on infectious bursal disease virus and Newcastle disease virus...
IBD - Infectious Bursal Disease Virus - BioChek, smart veterinary diagnostics
Poultry Infectious Bursal Disease Virus Antigen Rapid Test
Frontiers | Mast Cells and Influenza A Virus: Association with Allergic Responses and Beyond
Protection capability of recombinant plasmid DNA vaccine containing VP2 gene of very virulent infectious bursal disease virus...
Characteristics of bursal T lymphocytes induced by infectious bursal disease virus<...
Figure 2 - Surveillance for Influenza Viruses in Poultry and Swine, West Africa, 2006-2008 - Volume 18, Number 9-September 2012...
Detection and Phylogenetic Analysis of Infectious Bursal Disease Virus Based on both Genome Segments A and B Isolated from...
Complete genomes: Birnaviridae
Biomarkers Search
Vaccines | Free Full-Text | Possible Cross-Reactivity between SARS-CoV-2 Proteins, CRM197 and Proteins in Pneumococcal Vaccines...
MeSH Browser
2006
BIOCELL | Free Full-Text | Indian medicinal plants are effective in the treatment and management of COVID-19
Biotin Anti-Chicken IgA, A-1 | SouthernBiotech
Current Science
Detail VMP
Scientists Develop Assay For Detecting vvIBDV | The Poultry Site
DeCS
MeSH Browser
The effects of different velogenic NDV infections on the chicken bursa of Fabricius | BMC Veterinary Research | Full Text
Virologica Sinica
Updates to the Biotechnology Regulatory Services BQMS Program, 5523-5524 [2017-01017] :: Animal And Plant Health Inspection...
Passive Immunity in Infectious Bursal Disease; Role of Maternally
Search
Kaushik P. - eFlora of India
DeCS 2018 - July 31, 2018 version
IBDV13
- The in vitro and in vivo effects of chicken interferon alpha on infectious bursal disease virus (IBDV) infection were investigated in this study. (nih.gov)
- The recombinant interferon suppressed IBDV plaque formation in a dose-dependent manner and ameliorated IBDV and Newcastle disease virus infection in both specific-pathogen-free (SPF) and commercial chickens. (nih.gov)
- The Poultry Infectious bursal disease Virus Antigen Rapid Test is a sandwich lateral flow immunochromatographic method for the qualitative detection of infectious bursal disease virus (IBDV Ag) in poultry secretions. (hwtai.com)
- Infectious bursal disease virus (IBDV) is an avian lymphotropic virus that causes immunosuppression. (korea.ac.kr)
- When specific-pathogen-free chickens were exposed to a pathogenic strain of IBDV (IM), the virus rapidly destroyed B cells in the bursa of Fabricius. (korea.ac.kr)
- We studied the characteristics of intrabursal T lymphocytes in IBDV-infected chickens and examined whether T cells were involved in virus clearance. (korea.ac.kr)
- In addition, IBDV-induced bursal T cells produced elevated levels of interleukin-6-like factor and nitric oxide-inducing factor in vitro. (korea.ac.kr)
- Spleen and bursal cells of IBDV-infected chickens had upregulated gamma interferon gene expression in comparison with virus-free chickens. (korea.ac.kr)
- In recent years, the re-emergence of virulent strains of infectious bursal disease virus (IBDV) has resulted in substantial economic losses in Pakistan despite mass and intense vaccination regimens. (researcherslinks.com)
- IBDV is one of the most economically significant diseases of the poultry industry. (thepoultrysite.com)
- IBDV is able to rapidly produce mutated viruses that are resistant to vaccines. (thepoultrysite.com)
- The indirect economic impact of the disease is also considerable, due to virus-induced immune-suppression and/or potential interactions between IBDV and other viruses, bacteria or parasites, (Van den Berg et al. (thepoultrypunch.com)
- Humoral immunity plays a very important role in protecting the birds against Infectious Bursal Disease Virus (IBDV). (thepoultrypunch.com)
Virulent7
- Protection capability of recombinant plasmid DNA vaccine containing VP2 gene of very virulent infectious bursal disease virus in chickens adjuvanted with CpG oligodeoxynucleotide. (bvsalud.org)
- In the present study the efficacy of recombinant plasmids DNA vaccine encoding VP2 gene of very virulent strain of infectious bursal disease virus (vvIBDV) isolated from Pakistan was investigated with or without coadministration of cytocine- phosphate - guanine oligodeoxynucleotide (CpG ODN) to protect the chickens against the disease . (bvsalud.org)
- 6. Molecular characterisation of very virulent infectious bursal disease viruses in Taiwan. (nih.gov)
- 13. Development of SYBR green I based one-step real-time RT-PCR assay for the detection and differentiation of very virulent and classical strains of infectious bursal disease virus. (nih.gov)
- Impaired intestinal mucosal immunity in specific-pathogen-free chickens after infection with very virulent infectious bursal disease virus. (southernbiotech.com)
- Animal Health Scientist, Daral Jackwood, Ph.D. has developed a validated REAL-TIME RT-PCR ASSAY (patent pending) for the rapid detection of nucleotide sequences that are unique to very virulent Infectious Bursal Disease Virus (vvIBDV) strains affecting the poultry industry. (thepoultrysite.com)
- Virulent Newcastle disease virus (NDV) was reported to cause rapid depletion of chicken bursa of Fabricius. (biomedcentral.com)
Chickens15
- The Infectious Bursal Disease Virus Antibody test kit measures the amount of antibodies to the Infectious Bursal Disease Virus in the serum of chickens. (biochek.com)
- 2. Detection of infectious bursal disease virus in experimentally infected chickens by in situ hybridization. (nih.gov)
- 4. Detection of infectious bursal disease viruses in commercially reared chickens using the reverse transcriptase/polymerase chain reaction-restriction endonuclease assay. (nih.gov)
- 5. Applications of the polymerase chain reaction to detect infectious bursal disease virus in naturally infected chickens. (nih.gov)
- 8. Genetic heterogeneity in the VP2 gene of infectious bursal disease viruses detected in commercially reared chickens. (nih.gov)
- 10. Detection and persistence of infectious bursal disease virus in specific-pathogen-free and commercial broiler chickens. (nih.gov)
- 11. Molecular characterization of seven field isolates of infectious bursal disease virus obtained from commercial broiler chickens. (nih.gov)
- 17. Mice as potential carriers of infectious bursal disease virus in chickens. (nih.gov)
- The role of mucosal antibody in immunity to infectious laryngotracheitis virus in chickens. (southernbiotech.com)
- Effects of chicken intestinal antimicrobial peptides on humoral immunity of chickens and antibody titres after vaccination with infectious bursal disease virus vaccine in chicken. (southernbiotech.com)
- Mucosal immune responses against live Newcastle disease vaccine in immunosuppressed chickens. (southernbiotech.com)
- 13. Cheng J, Li Q, Shi W, Zhong X. Effects of Huangqi Maxingshigan decoction on infectious laryngotracheitis in chickens. (southernbiotech.com)
- 15. Zhang D, Shi W, Zhao Y, Zhong X. Adjuvant effects of Sijunzi decoction in chickens orally vaccinated with attenuated Newcastle-disease vaccine. (southernbiotech.com)
- The attenuated vaccine is intended for use in healthy 18-day-old or older embryonated eggs or day-old chickens, as an aid in the prevention of infectious bursal disease, Marek's disease, and Newcastle disease. (justia.com)
- The disease is highly contagious, affects young chickens and is characterized by the destruction of the lymphoid organs, and in particular the bursa of Fabricius, where B-lymphocytes mature and differentiate. (thepoultrypunch.com)
Vaccine6
- Efficacy and safety of an infectious bursal disease virus intermediate vaccine in ovo. (nih.gov)
- Product: Bursal Disease-Marek's Disease-Newcastle Disease Vaccine, Serotype 3, Live Marek's Disease Vector. (justia.com)
- The above-mentioned product is a live Marek's Disease serotype 3 vaccine virus containing a gene from the Newcastle disease virus and a gene from the infectious bursal disease virus. (justia.com)
- This vaccine would be the recombinant fraction used in combination with a conventional live Marek's disease vaccine virus, either a serotype 1 or serotype 2 strain, during the field safety tests. (justia.com)
- Howeve, the duration and uniformity of the immunity thus conferred upon chicks, will to a great extent, depend on the antigenic specificity of the virus present in the vaccine used to hyper-immunize the hens, (Box. (thepoultrypunch.com)
- YF-VAX ® , Yellow Fever Vaccine, for subcutaneous use, is prepared by culturing the 17D-204 strain of yellow fever virus in living avian leukosis virus-free (ALV-free) chicken embryos. (nih.gov)
Viral6
- 12. Infectious bursal disease viral RNA amplification using RT/PCR from bursa tissue following phenol: chloroform inactivation of the virus. (nih.gov)
- 15. Comparative analysis of viral RNA and apoptotic cells in bursae following infection with infectious bursal disease virus. (nih.gov)
- The Interaction of Viral Nucleocapsid Protein with GRP94 and HSP27 in Brains of Suckling M ice Experimentally Infected with Hantaan virus[J]. Virologica Sinica, 2003, 18(2): 104-107. (virosin.org)
- Infectious Bursal disease (IBD) is a viral infection, affecting the immune system of poultry. (thepoultrypunch.com)
- This response is presumed to result from initial infection of cells in the dermis or other subcutaneous tissues near the injection site, with subsequent replication and limited spread of virus leading to the processing and presentation of viral antigens to the immune system, as would occur during infection with wild-type yellow fever virus. (nih.gov)
- Although a great deal is known about the synthesis of unintegrated double stranded viral DNA by the virus-coded enzyme, reverse transcriptase, we know only the structure features of integrated (proviral) DNA and none of the functional properties of the integrative mechanism. (nih.gov)
Avibirnavirus1
- Especie de AVIBIRNAVIRUS causante de intensa inflamación de la bolsa de Fabricio en los pollos y otras aves de corral. (bvsalud.org)
Detection9
- Highly sensitive and specific ELISA for detection of antibodies against Infectious Bursal disease. (biochek.com)
- 1. In situ hybridization, immunohistochemistry, and in situ reverse transcription-polymerase chain reaction for detection of infectious bursal disease virus. (nih.gov)
- 3. Tissue print hybridisation and reverse transcriptase PCR in the detection of infectious bursal disease viruses in bursal tissues. (nih.gov)
- 7. Simplified sample processing combined with a sensitive nested polymerase chain reaction assay for detection of infectious bursal disease virus in the bursa of Fabricus. (nih.gov)
- 9. Direct detection of infectious bursal disease virus from clinical samples by in situ reverse transcriptase-linked polymerase chain reaction. (nih.gov)
- 16. Detection and characterization of infectious bursal disease viruses in broilers at processing. (nih.gov)
- 18. Molecular detection of infectious bursal disease virus by polymerase chain reaction. (nih.gov)
- 19. Evaluation of the immune response and detection of infectious bursal disease viruses by reverse transcriptase-polymerase chain reaction and enzyme-linked immunosorbent assay after in ovo vaccination of commercial broilers. (nih.gov)
- 20. Development of reverse-transcription loop-mediated isothermal amplification for the detection of infectious bursal disease virus. (nih.gov)
Poultry3
- Poultry Infectious bursal disease Virus Antigen Rapid Test is based on sandwich lateral flow immunochromatographic analysis. (hwtai.com)
- Infectious bursal disease (IBD) is one of the most important immunosuppressive diseases of the poultry and has been a constraint on sustainable food security around the globe, including Pakistan. (researcherslinks.com)
- In countries without the virus, the assay would be a first line of defense needed to prevent vvIBDV from entering domestic poultry operations. (thepoultrysite.com)
Antigen1
- The device can accurately indicate the presence of infectious bursal disease virus antigen in the sample. (hwtai.com)
Chicken5
- This highly contagious, immunosuppresive disease has been identified in chicken flocks on nearly every continent of the world including Europe, Asia, South America, Central America and the Caribbean countries. (thepoultrysite.com)
- Subsequently, apoptosis of enriched bursal IgM+ cells was determined to help us elucidate possible host pathogen relationships between the chicken bursa of Fabricius and NDV infection. (biomedcentral.com)
- However, of the two viruses, we observed that NDV AF2240 induced a greater magnitude of apoptosis in chicken bursa IgM+ cells in comparison to IBS002. (biomedcentral.com)
- ZHOU Bin.CHAO Rui-bing, LU Yin-hua, CHEN De-sheng.CHEN Pu-yang*, Amplification with Random PCR method and Researches for the DNA Fragment of the genome of Chicken emb~o lethal orphan virus[J]. Virologica Sinica, 2003, 18(2): 137-140. (virosin.org)
- 1994). High levels of neutralizing antibodies in the chicken block the virus infecting the bursa. (thepoultrypunch.com)
Newcastle3
- Newcastle disease virus is classified under the order Mononegavirales in the family Paramyxoviridae, which is divided into two subfamilies, Paramyxovirinae and Pneumovirinae [ 1 ]. (biomedcentral.com)
- It was reported that a few of the first outbreaks of Newcastle disease occurred in Newcastle Upon Tyne, England and also Java, Indonesia during the early 1900s [ 2 ]. (biomedcentral.com)
- Activity of Newcastle disease and Infectious bursal disease viruses in ducks and guinea fowls in Jos, Nigeria. (sokvetjournal.net)
Infection4
- Due to the large dynamic range, the Infectious Bursal Disease Virus Antibody test kit is suitable for differentiation between live, inactivated and/or recombinant vaccinated flocks and field infection within the same kit. (biochek.com)
- The target cell of virus is the B-lymphocyte in an immature stage, and the infection when not fatal, causes an immune-suppression in most cases temporary, the degree of which is difficult to determine. (thepoultrypunch.com)
- Severe immunosuppression can be due to a variety of conditions, including congenital immunodeficiency, human immunodeficiency virus (HIV) infection, leukemia, lymphoma, generalized malignancy or therapy with alkylating agents, antimetabolites, radiation, or large amounts of corticosteroids. (cdc.gov)
- for others, such as HIV infection, the spectrum of disease severity due to disease or treatment stage will determine the degree to which the immune system is compromised. (cdc.gov)
Antibodies2
- With lower level of antibodies, sufficient virus is neutralized to prevent clinical disease. (thepoultrypunch.com)
- The titer of virus neutralizing antibodies in sera of vaccinees is a surrogate for efficacy. (nih.gov)
Strain2
- The pathological manifestations observed upon NDV infections are contributed by factors such as the strain of the virus, species of birds, concurrent diseases and preexisting immunity which can affect the severity of the disease [ 10 ]. (biomedcentral.com)
- Direct losses due to IBD are linked to specific mortality, and depend on the dose and virulence of the virus strain, the age and breed of the birds, and the presence or absence of passive immunity. (thepoultrypunch.com)
20001
- 2000). Infectious Bursal disease is currently an international problem almost all countries of the world have encountered the incidence of the disease. (thepoultrypunch.com)
Gene1
- Cloning and Sequencing of the Capsid Protein Gene of Rabbit hemorrhagic disease virus Isolate W X84[J]. Virologica Sinica, 2003, 18(2): 129-133. (virosin.org)
Antibody1
- Inactivated vaccines are essentially used to produce high, uniform and persistent antibody titers in the hens prior to lay that have been vaccinated with a live virus or have been naturally infected through exposure to the virus on the farm. (thepoultrypunch.com)
Vitro2
- In vitro , in vivo as well as in silico validation, these phytochemicals can help us to manage and treat COVID-19 disease. (techscience.com)
- He has used techniques for in vitro mutagenesis to produce murine leukemia virus (MLV) pol mutants that retain reverse transcriptase activity but have lesions in the endonuclease domain. (nih.gov)
Centers for Diseas4
- Centers for Disease Control and Prevention. (cdc.gov)
- The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. (cdc.gov)
- The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. (cdc.gov)
- SUGGESTED CITATION: Centers for Disease Control and Prevention. (cdc.gov)
Bursa1
- This disease damages the bursa of Fabricius (BF), which causes immunosuppression in birds. (researcherslinks.com)
Molecular2
- 14. Molecular characterization of Brazilian infectious bursal disease viruses. (nih.gov)
- Ht DEPARTMENT OF BIOCHEMISTRY & BIOPHYSICS Wa ANNUAL REPORT My 1982 1983 UNIVERSITY OF CALIFORNIA SAN FRANCISCO HAROLD E. VARMUS Professor of Microbiology and Immunology In this laboratory, we use two intriguing and medically-- important classes of animal viruses~--the retroviruses and hepatitis B-type viruses-~-as points of departure for studying various aspects of the behaviour of eukaryotic cells at the molecular level. (nih.gov)
Vaccines4
- Veterinary biological products include viruses, serums, toxins, and analogous products of natural or synthetic origin, such as vaccines, antitoxins, or the immunizing components of microorganisms intended for the diagnosis, treatment, or prevention of diseases in domestic animals. (justia.com)
- ACIP statements on individual vaccines or immune globulins should be consulted for more details on safety and efficacy and on the epidemiology of the diseases. (cdc.gov)
- For specific immunocompromising conditions (e.g., asplenia), such patients may be at higher risk for certain diseases, and additional vaccines, particularly bacterial polysaccharide vaccines {Haemophilus influenzae type b (Hib), pneumococcal and meningococcal}, are recommended for them. (cdc.gov)
- The immunosuppressive effects of steroid treatment vary, but many clinicians consider a dose equivalent to either 2 mg/kg of body weight or a total of 20 mg/day of prednisone as sufficiently immunosuppressive to raise concern about the safety of immunization with live-virus vaccines. (cdc.gov)
Isolate1
- Identification and Grouping Study of Potato virus X Hunan Isolate[J]. Virologica Sinica, 2003, 18(2): 119-123. (virosin.org)
Tissue1
- Flow cytometric analysis of single-cell suspensions of the bursal tissue revealed that T cells were first detectable at 4 days postinoculation (p.i. (korea.ac.kr)
Avian influ1
- AIV, avian influenza virus. (cdc.gov)
Intense1
- Severe pathological condition of the organ is commonly associated with high levels of virus replication, intense inflammatory response and also the degree of apoptosis. (biomedcentral.com)
Severity1
- Classical swine fever (CSF) causes major losses in pig farming, with various degrees of disease severity. (irta.cat)
Syndrome1
- Search, retrieve and analyze Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) sequences in NCBI Virus . (nih.gov)
Particles3
- This virus was shown to survive when airborne in small particles, either in the laboratory or open air [ 7 ]. (biomedcentral.com)
- It was primarily identified as potato virus X by double-stranded RNA analysis, host reaction tests and morphological observation of virus particles and inclusions. (virosin.org)
- These mutants appear to affect the integrative mechanism since mutant virus particles can enter cells and make full-sized unintegrated DNA, both linear and circular forms, but no virus is produced by the infected cells. (nih.gov)
Agent1
- Influenza A virus (IAV) is a widespread infectious agent commonly found in mammalian and avian species. (frontiersin.org)
Coronavirus2
- Coronavirus disease 2019 (COVID-19) is a global health issue without any proper medication. (techscience.com)
- There was a spike in research after the coronavirus disease 2019 (COVID-19) pandemic broke out in an effort to develop cures or medications for it. (techscience.com)
VvIBDV1
- In countries with vvIBDV, this assay is necessary for the effective monitoring and control of this devastating disease. (thepoultrysite.com)
Cells1
- At 7 days p.i., 65% of bursal cells were T cells and 7% were B cells. (korea.ac.kr)
Infections1
- Most yellow fever virus infections are asymptomatic. (nih.gov)
Incidence1
- While the incidence of end-stage kidney disease continues to increase globally, the use of home dialysis remains low in most developed countries. (openaire.eu)
Analysis1
- Multivariate analysis of the data showed a statistically significant relationship between the final diagnosis (16 diseases by a system according to The International Statistical Classification of Diseases and Related Health Problems 10th Revision (ICD-10) and age, season, and weight. (bvsalud.org)
Reverse1
- Prevalence of 8 avian viruses detected by reverse transcription PCRs of a subset of 2,427 tracheal and cloacal swab samples collected in live-bird markets, Benin and Togo, 2009. (cdc.gov)
Pandemic1
- Thus, it is necessary to find alternative ways to alleviate and treat IAV-induced disease during the early wave(s) of a novel pandemic IAV outbreak. (frontiersin.org)
Important1
- The first class of antiviral drugs targets the M2 ion channel (amantadanes), which is important for virus uncoating. (frontiersin.org)
Field1
- Exposure to any challenge with field virus has positive influence on the MDA titers. (thepoultrypunch.com)