Poisons: Substances which, when ingested, inhaled, or absorbed, or when applied to, injected into, or developed within the body in relatively small amounts may, by their chemical action, cause damage to structure or disturbance of function. (From Dorland, 27th ed)Poisoning: A condition or physical state produced by the ingestion, injection, inhalation of or exposure to a deleterious agent.Topoisomerase II Inhibitors: Compounds that inhibit the activity of DNA TOPOISOMERASE II. Included in this category are a variety of ANTINEOPLASTIC AGENTS which target the eukaryotic form of topoisomerase II and ANTIBACTERIAL AGENTS which target the prokaryotic form of topoisomerase II.Topoisomerase I Inhibitors: Compounds that inhibit the activity of DNA TOPOISOMERASE I.Dermatitis, Toxicodendron: An allergic contact dermatitis caused by exposure to plants of the genus Toxicodendron (formerly Rhus). These include poison ivy, poison oak, and poison sumac, all plants that contain the substance urushiol, a potent skin sensitizing agent. (From Dorland, 27th ed)Rodenticides: Substances used to destroy or inhibit the action of rats, mice, or other rodents.Amphibian Venoms: Venoms produced by frogs, toads, salamanders, etc. The venom glands are usually on the skin of the back and contain cardiotoxic glycosides, cholinolytics, and a number of other bioactive materials, many of which have been characterized. The venoms have been used as arrow poisons and include bufogenin, bufotoxin, bufagin, bufotalin, histrionicotoxins, and pumiliotoxin.DNA Topoisomerases, Type II: DNA TOPOISOMERASES that catalyze ATP-dependent breakage of both strands of DNA, passage of the unbroken strands through the breaks, and rejoining of the broken strands. These enzymes bring about relaxation of the supercoiled DNA and resolution of a knotted circular DNA duplex.Rodent Control: The reduction or regulation of the population of noxious, destructive, or dangerous rodents through chemical, biological, or other means.Household Products: Substances or materials used in the course of housekeeping or personal routine.Toxicodendron: A genus (formerly part of Rhus genus) of shrubs, vines, or trees that yields a highly allergenic oleoresin which causes a severe contact dermatitis (DERMATITIS, TOXICODENDRON). The most toxic species are Toxicodendron vernix (poison sumac), T. diversilobum (poison oak), and T. radicans (poison ivy). T. vernicifera yields a useful varnish from which certain enzymes (laccases) are obtained.Gastric Lavage: Medical procedure involving the emptying of contents in the stomach through the use of a tube inserted through the nose or mouth. It is performed to remove poisons or relieve pressure due to intestinal blockages or during surgery.DNA Topoisomerases, Type I: DNA TOPOISOMERASES that catalyze ATP-independent breakage of one of the two strands of DNA, passage of the unbroken strand through the break, and rejoining of the broken strand. DNA Topoisomerases, Type I enzymes reduce the topological stress in the DNA structure by relaxing the superhelical turns and knotted rings in the DNA helix.Antidotes: Agents counteracting or neutralizing the action of POISONS.Drug Overdose: Accidental or deliberate use of a medication or street drug in excess of normal dosage.4-Hydroxycoumarins: Substances found in many plants, containing the 4-hydroxycoumarin radical. They interfere with vitamin K and the blood clotting mechanism, are tightly protein-bound, inhibit mitochondrial and microsomal enzymes, and are used as oral anticoagulants.Anura: An order of the class Amphibia, which includes several families of frogs and toads. They are characterized by well developed hind limbs adapted for jumping, fused head and trunk and webbed toes. The term "toad" is ambiguous and is properly applied only to the family Bufonidae.Anacardiaceae: The sumac plant family in the order Sapindales, subclass Rosidae, class Magnoliopsida. They are tropical and subtropical trees, shrubs, and woody vines that have resin ducts in the bark. The sap of many of the species is irritating to the skin.Animals, PoisonousDNA Cleavage: A reaction that severs one of the covalent sugar-phosphate linkages between NUCLEOTIDES that compose the sugar phosphate backbone of DNA. It is catalyzed enzymatically, chemically or by radiation. Cleavage may be exonucleolytic - removing the end nucleotide, or endonucleolytic - splitting the strand in two.Amsacrine: An aminoacridine derivative that intercalates into DNA and is used as an antineoplastic agent.Camptothecin: An alkaloid isolated from the stem wood of the Chinese tree, Camptotheca acuminata. This compound selectively inhibits the nuclear enzyme DNA TOPOISOMERASES, TYPE I. Several semisynthetic analogs of camptothecin have demonstrated antitumor activity.Ipecac: A syrup made from the dried rhizomes of two different species, CEPHAELIS ipecacuanha and C. acuminata. They contain EMETINE, cephaeline, psychotrine and other ISOQUINOLINES. Ipecac syrup is used widely as an emetic acting both locally on the gastric mucosa and centrally on the chemoreceptor trigger zone.Etoposide: A semisynthetic derivative of PODOPHYLLOTOXIN that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitotic phase of cell division, and lead to cell death. Etoposide acts primarily in the G2 and S phases of the cell cycle.Topoisomerase Inhibitors: Compounds that inhibit the activity of DNA TOPOISOMERASES.Catechols: A group of 1,2-benzenediols that contain the general formula R-C6H5O2.Emetics: Agents that cause vomiting. They may act directly on the gastrointestinal tract, bringing about emesis through local irritant effects, or indirectly, through their effects on the chemoreceptor trigger zone in the postremal area near the medulla.Chlorpropham: A carbamate that is used as an herbicide and as a plant growth regulator.omega-Chloroacetophenone: A potent eye, throat, and skin irritant. One of its uses is as a riot control agent.Accidents, HomePlant Poisoning: Poisoning by the ingestion of plants or its leaves, berries, roots or stalks. The manifestations in both humans and animals vary in severity from mild to life threatening. In animals, especially domestic animals, it is usually the result of ingesting moldy or fermented forage.Intercalating Agents: Agents that are capable of inserting themselves between the successive bases in DNA, thus kinking, uncoiling or otherwise deforming it and therefore preventing its proper functioning. They are used in the study of DNA.Legislation, Drug: Laws concerned with manufacturing, dispensing, and marketing of drugs.Phosgene: A highly toxic gas that has been used as a chemical warfare agent. It is an insidious poison as it is not irritating immediately, even when fatal concentrations are inhaled. (From The Merck Index, 11th ed, p7304)Toxicology: The science concerned with the detection, chemical composition, and biological action of toxic substances or poisons and the treatment and prevention of toxic manifestations.Thevetia: A plant genus of the family APOCYNACEAE. Members contain thevetin.Razoxane: An antimitotic agent with immunosuppressive properties.Designer Drugs: Drugs designed and synthesized, often for illegal street use, by modification of existing drug structures (e.g., amphetamines). Of special interest are MPTP (a reverse ester of meperidine), MDA (3,4-methylenedioxyamphetamine), and MDMA (3,4-methylenedioxymethamphetamine). Many drugs act on the aminergic system, the physiologically active biogenic amines.Phosphines: Inorganic or organic compounds derived from phosphine (PH3) by the replacement of H atoms. (From Grant & Hackh's Chemical Dictionary, 5th ed)DNA Damage: Injuries to DNA that introduce deviations from its normal, intact structure and which may, if left unrepaired, result in a MUTATION or a block of DNA REPLICATION. These deviations may be caused by physical or chemical agents and occur by natural or unnatural, introduced circumstances. They include the introduction of illegitimate bases during replication or by deamination or other modification of bases; the loss of a base from the DNA backbone leaving an abasic site; single-strand breaks; double strand breaks; and intrastrand (PYRIMIDINE DIMERS) or interstrand crosslinking. Damage can often be repaired (DNA REPAIR). If the damage is extensive, it can induce APOPTOSIS.Regional Medical Programs: Coordination of activities and programs among health care institutions within defined geographic areas for the purpose of improving delivery and quality of medical care to the patients. These programs are mandated under U.S. Public Law 89-239.Suicide, Attempted: The unsuccessful attempt to kill oneself.Drug Packaging: Containers, packaging, and packaging materials for drugs and BIOLOGICAL PRODUCTS. These include those in ampule, capsule, tablet, solution or other forms. Packaging includes immediate-containers, secondary-containers, and cartons. In the United States, such packaging is controlled under the Federal Food, Drug, and Cosmetic Act which also stipulates requirements for tamper-resistance and child-resistance. Similar laws govern use elsewhere. (From Code of Federal Regulations, 21 CFR 1 Section 210, 1993) DRUG LABELING is also available.Organophosphate Poisoning: Poisoning due to exposure to ORGANOPHOSPHORUS COMPOUNDS, such as ORGANOPHOSPHATES; ORGANOTHIOPHOSPHATES; and ORGANOTHIOPHOSPHONATES.Alkaloids: Organic nitrogenous bases. Many alkaloids of medical importance occur in the animal and vegetable kingdoms, and some have been synthesized. (Grant & Hackh's Chemical Dictionary, 5th ed)Saxitoxin: A compound that contains a reduced purine ring system but is not biosynthetically related to the purine alkaloids. It is a poison found in certain edible mollusks at certain times; elaborated by GONYAULAX and consumed by mollusks, fishes, etc. without ill effects. It is neurotoxic and causes RESPIRATORY PARALYSIS and other effects in MAMMALS, known as paralytic SHELLFISH poisoning.Antineoplastic Agents, Phytogenic: Agents obtained from higher plants that have demonstrable cytostatic or antineoplastic activity.Mushroom Poisoning: Poisoning from ingestion of mushrooms, primarily from, but not restricted to, toxic varieties.Carbon Monoxide Poisoning: Toxic asphyxiation due to the displacement of oxygen from oxyhemoglobin by carbon monoxide.Health Educators: Professionals who plan, organize and direct health education programs for the individual, groups and the community.Aneugens: Agents which affect CELL DIVISION and the MITOTIC SPINDLE APPARATUS resulting in the loss or gain of whole CHROMOSOMES, thereby inducing an ANEUPLOIDY.Riot Control Agents, Chemical: Chemical substances which are employed during a riot in order to control or disperse the rioting parties.Judaism: The religion of the Jews characterized by belief in one God and in the mission of the Jews to teach the Fatherhood of God as revealed in the Hebrew Scriptures. (Webster, 3d ed)Antineoplastic Agents: Substances that inhibit or prevent the proliferation of NEOPLASMS.Enzyme Inhibitors: Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction.Charcoal: An amorphous form of carbon prepared from the incomplete combustion of animal or vegetable matter, e.g., wood. The activated form of charcoal is used in the treatment of poisoning. (Grant & Hackh's Chemical Dictionary, 5th ed)Coroners and Medical Examiners: Physicians appointed to investigate all cases of sudden or violent death.Topotecan: An antineoplastic agent used to treat ovarian cancer. It works by inhibiting DNA TOPOISOMERASES, TYPE I.Teniposide: A semisynthetic derivative of PODOPHYLLOTOXIN that exhibits antitumor activity. Teniposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent cells from entering into the mitotic phase of the cell cycle, and lead to cell death. Teniposide acts primarily in the G2 and S phases of the cycle.Nocodazole: Nocodazole is an antineoplastic agent which exerts its effect by depolymerizing microtubules.Ranidae: The family of true frogs of the order Anura. The family occurs worldwide except in Antarctica.Madagascar: One of the Indian Ocean Islands off the southeast coast of Africa. Its capital is Antananarivo. It was formerly called the Malagasy Republic. Discovered by the Portuguese in 1500, its history has been tied predominantly to the French, becoming a French protectorate in 1882, a French colony in 1896, and a territory within the French union in 1946. The Malagasy Republic was established in the French Community in 1958 but it achieved independence in 1960. Its name was changed to Madagascar in 1975. (From Webster's New Geographical Dictionary, 1988, p714)Pesticides: Chemicals used to destroy pests of any sort. The concept includes fungicides (FUNGICIDES, INDUSTRIAL); INSECTICIDES; RODENTICIDES; etc.Cell Wall Skeleton: A mucoprotein found in the cell wall of various types of bacteria. It has adjuvant and antitumor activities and has been used to augment the production of lymphokine-activated killer (LAK) cells.Environmental Illness: A polysymptomatic condition believed by clinical ecologists to result from immune dysregulation induced by common foods, allergens, and chemicals, resulting in various physical and mental disorders. The medical community has remained largely skeptical of the existence of this "disease", given the plethora of symptoms attributed to environmental illness, the lack of reproducible laboratory abnormalities, and the use of unproven therapies to treat the condition. (From Segen, Dictionary of Modern Medicine, 1992)PanamaBenzodioxoles: Compounds based on benzene fused to oxole. They can be formed from methylated CATECHOLS such as EUGENOL.Accident Prevention: Efforts and designs to reduce the incidence of unexpected undesirable events in various environments and situations.Arthropod Venoms: Venoms from animals of the phylum Arthropoda. Those most investigated are from scorpions and spiders of the class Arachnidae and from ant, bee, and wasp families of the Insecta order Hymenoptera. The venoms contain protein toxins, enzymes, and other bioactive substances and may be lethal to man.Indenes: A family of fused-ring hydrocarbons isolated from coal tar that act as intermediates in various chemical reactions and are used in the production of coumarone-indene resins.Azides: Organic or inorganic compounds that contain the -N3 group.Shellfish Poisoning: Poisoning from toxins present in bivalve mollusks that have been ingested. Four distinct types of shellfish poisoning are recognized based on the toxin involved.Methylphenazonium Methosulfate: Used as an electron carrier in place of the flavine enzyme of Warburg in the hexosemonophosphate system and also in the preparation of SUCCINIC DEHYDROGENASE.Cyanides: Inorganic salts of HYDROGEN CYANIDE containing the -CN radical. The concept also includes isocyanides. It is distinguished from NITRILES, which denotes organic compounds containing the -CN radical.Fluoroacetates: Derivatives of acetic acid with one or more fluorines attached. They are almost odorless, difficult to detect chemically, and very stable. The acid itself, as well as the derivatives that are broken down in the body to the acid, are highly toxic substances, behaving as convulsant poisons with a delayed action. (From Miall's Dictionary of Chemistry, 5th ed)Hotlines: A direct communication system, usually telephone, established for instant contact. It is designed to provide special information and assistance through trained personnel and is used for counseling, referrals, and emergencies such as poisonings and threatened suicides.DNA: A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine).Shellfish: Aquatic invertebrates belonging to the phylum MOLLUSCA or the subphylum CRUSTACEA, and used as food.Methyl n-Butyl Ketone: An industrial solvent which causes nervous system degeneration. MBK is an acronym often used to refer to it.Marine Toxins: Toxic or poisonous substances elaborated by marine flora or fauna. They include also specific, characterized poisons or toxins for which there is no more specific heading, like those from poisonous FISHES.Bufonidae: The family of true toads belonging to the order Anura. The genera include Bufo, Ansonia, Nectophrynoides, and Atelopus.Prescription Drug Misuse: Improper use of drugs or medications outside the intended purpose, scope, or guidelines for use. This is in contrast to MEDICATION ADHERENCE, and distinguished from DRUG ABUSE, which is a deliberate or willful action.Mitosis: A type of CELL NUCLEUS division by means of which the two daughter nuclei normally receive identical complements of the number of CHROMOSOMES of the somatic cells of the species.Electric Power Supplies: Devices that control the supply of electric current for running electrical equipment.Molecular Structure: The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds.AcridinesSpindle Apparatus: A microtubule structure that forms during CELL DIVISION. It consists of two SPINDLE POLES, and sets of MICROTUBULES that may include the astral microtubules, the polar microtubules, and the kinetochore microtubules.Hydrogen Cyanide: Hydrogen cyanide (HCN); A toxic liquid or colorless gas. It is found in the smoke of various tobacco products and released by combustion of nitrogen-containing organic materials.Gas PoisoningAntigens, Neoplasm: Proteins, glycoprotein, or lipoprotein moieties on surfaces of tumor cells that are usually identified by monoclonal antibodies. Many of these are of either embryonic or viral origin.Dinitrophenols: Organic compounds that contain two nitro groups attached to a phenol.Heterocyclic Compounds, Bridged-Ring: A class of organic compounds which contain two rings that share a pair of bridgehead carbon atoms.Demecolcine: An alkaloid isolated from Colchicum autumnale L. and used as an antineoplastic.IndolizinesStreet Drugs: Drugs obtained and often manufactured illegally for the subjective effects they are said to produce. They are often distributed in urban areas, but are also available in suburban and rural areas, and tend to be grossly impure and may cause unexpected toxicity.Carbonyl Cyanide m-Chlorophenyl Hydrazone: A proton ionophore. It is commonly used as an uncoupling agent and inhibitor of photosynthesis because of its effects on mitochondrial and chloroplast membranes.Thioridazine: A phenothiazine antipsychotic used in the management of PHYCOSES, including SCHIZOPHRENIA.Aegle: A plant genus of the family RUTACEAE.2,4-Dinitrophenol: A toxic dye, chemically related to trinitrophenol (picric acid), used in biochemical studies of oxidative processes where it uncouples oxidative phosphorylation. It is also used as a metabolic stimulant. (Stedman, 26th ed)Nonprescription Drugs: Medicines that can be sold legally without a DRUG PRESCRIPTION.Electromagnetic Radiation: Waves of oscillating electric and MAGNETIC FIELDS which move at right angles to each other and outward from the source.Azulenes: Compounds based on a seven-membered ring fused to a five-membered ring. Heat can rearrange them to NAPHTHALENES which have two fused six-membered rings. They are similar to guaiazulenes which are SESQUITERPENES with a six-membered ring fused to a five-membered ring.DNA-Binding Proteins: Proteins which bind to DNA. The family includes proteins which bind to both double- and single-stranded DNA and also includes specific DNA binding proteins in serum which can be used as markers for malignant diseases.Fishes, PoisonousDinoflagellida: Flagellate EUKARYOTES, found mainly in the oceans. They are characterized by the presence of transverse and longitudinal flagella which propel the organisms in a rotating manner through the water. Dinoflagellida were formerly members of the class Phytomastigophorea under the old five kingdom paradigm.Sodium Oxybate: The sodium salt of 4-hydroxybutyric acid. It is used for both induction and maintenance of ANESTHESIA.Toxins, Biological: Specific, characterizable, poisonous chemicals, often PROTEINS, with specific biological properties, including immunogenicity, produced by microbes, higher plants (PLANTS, TOXIC), or ANIMALS.Plants, Toxic: Plants or plant parts which are harmful to man or other animals.Databases, Factual: Extensive collections, reputedly complete, of facts and data garnered from material of a specialized subject area and made available for analysis and application. The collection can be automated by various contemporary methods for retrieval. The concept should be differentiated from DATABASES, BIBLIOGRAPHIC which is restricted to collections of bibliographic references.Tubulin Modulators: Agents that interact with TUBULIN to inhibit or promote polymerization of MICROTUBULES.Mutagens: Chemical agents that increase the rate of genetic mutation by interfering with the function of nucleic acids. A clastogen is a specific mutagen that causes breaks in chromosomes.Micronuclei, Chromosome-Defective: Defective nuclei produced during the TELOPHASE of MITOSIS or MEIOSIS by lagging CHROMOSOMES or chromosome fragments derived from spontaneous or experimentally induced chromosomal structural changes.Dichlororibofuranosylbenzimidazole: An RNA polymerase II transcriptional inhibitor. This compound terminates transcription prematurely by selective inhibition of RNA synthesis. It is used in research to study underlying mechanisms of cellular regulation.Cell Line, Tumor: A cell line derived from cultured tumor cells.Time Factors: Elements of limited time intervals, contributing to particular results or situations.DNA Breaks, Double-Stranded: Interruptions in the sugar-phosphate backbone of DNA, across both strands adjacently.AccidentsHerbicides: Pesticides used to destroy unwanted vegetation, especially various types of weeds, grasses (POACEAE), and woody plants. Some plants develop HERBICIDE RESISTANCE.Hazardous Substances: Elements, compounds, mixtures, or solutions that are considered severely harmful to human health and the environment. They include substances that are toxic, corrosive, flammable, or explosive.Podophyllotoxin: A lignan (LIGNANS) found in PODOPHYLLIN resin from the roots of PODOPHYLLUM plants. It is a potent spindle poison, toxic if taken internally, and has been used as a cathartic. It is very irritating to skin and mucous membranes, has keratolytic actions, has been used to treat warts and keratoses, and may have antineoplastic properties, as do some of its congeners and derivatives.Physicians' Offices: The room or rooms in which the physician and staff provide patient care. The offices include all rooms in the physician's office suite.Sri LankaSodium Azide: A cytochrome oxidase inhibitor which is a nitridizing agent and an inhibitor of terminal oxidation. (From Merck Index, 12th ed)San FranciscoAntivenins: Antisera used to counteract poisoning by animal VENOMS, especially SNAKE VENOMS.Colchicine: A major alkaloid from Colchicum autumnale L. and found also in other Colchicum species. Its primary therapeutic use is in the treatment of gout, but it has been used also in the therapy of familial Mediterranean fever (PERIODIC DISEASE).IllinoisChloromercuribenzoates: Chloride and mercury-containing derivatives of benzoic acid.Arsenates: Inorganic or organic salts and esters of arsenic acid.Color: The visually perceived property of objects created by absorption or reflection of specific wavelengths of light.G2 Phase: The period of the CELL CYCLE following DNA synthesis (S PHASE) and preceding M PHASE (cell division phase). The CHROMOSOMES are tetraploid in this point.Drug Resistance, Neoplasm: Resistance or diminished response of a neoplasm to an antineoplastic agent in humans, animals, or cell or tissue cultures.Dose-Response Relationship, Drug: The relationship between the dose of an administered drug and the response of the organism to the drug.Pigmentation DisordersBivalvia: A class in the phylum MOLLUSCA comprised of mussels; clams; OYSTERS; COCKLES; and SCALLOPS. They are characterized by a bilaterally symmetrical hinged shell and a muscular foot used for burrowing and anchoring.Bridged Compounds: Cyclic hydrocarbons that contain multiple rings and share one or more atoms.Retrospective Studies: Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.Nucleic Acid Synthesis Inhibitors: Compounds that inhibit cell production of DNA or RNA.TexasMicrotubules: Slender, cylindrical filaments found in the cytoskeleton of plant and animal cells. They are composed of the protein TUBULIN and are influenced by TUBULIN MODULATORS.Dermoscopy: A noninvasive technique that enables direct microscopic examination of the surface and architecture of the SKIN.Skin Pigmentation: Coloration of the skin.Uncoupling Agents: Chemical agents that uncouple oxidation from phosphorylation in the metabolic cycle so that ATP synthesis does not occur. Included here are those IONOPHORES that disrupt electron transfer by short-circuiting the proton gradient across mitochondrial membranes.Emergency Service, Hospital: Hospital department responsible for the administration and provision of immediate medical or surgical care to the emergency patient.Cell Cycle: The complex series of phenomena, occurring between the end of one CELL DIVISION and the end of the next, by which cellular material is duplicated and then divided between two daughter cells. The cell cycle includes INTERPHASE, which includes G0 PHASE; G1 PHASE; S PHASE; and G2 PHASE, and CELL DIVISION PHASE.Apoptosis: One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.Costa RicaConsumer Product SafetyAntibiotics, Antineoplastic: Chemical substances, produced by microorganisms, inhibiting or preventing the proliferation of neoplasms.DNA Repair: The reconstruction of a continuous two-stranded DNA molecule without mismatch from a molecule which contained damaged regions. The major repair mechanisms are excision repair, in which defective regions in one strand are excised and resynthesized using the complementary base pairing information in the intact strand; photoreactivation repair, in which the lethal and mutagenic effects of ultraviolet light are eliminated; and post-replication repair, in which the primary lesions are not repaired, but the gaps in one daughter duplex are filled in by incorporation of portions of the other (undamaged) daughter duplex. Excision repair and post-replication repair are sometimes referred to as "dark repair" because they do not require light.Polyploidy: The chromosomal constitution of a cell containing multiples of the normal number of CHROMOSOMES; includes triploidy (symbol: 3N), tetraploidy (symbol: 4N), etc.Mitoxantrone: An anthracenedione-derived antineoplastic agent.Paclitaxel: A cyclodecane isolated from the bark of the Pacific yew tree, TAXUS BREVIFOLIA. It stabilizes MICROTUBULES in their polymerized form leading to cell death.Drug Screening Assays, Antitumor: Methods of investigating the effectiveness of anticancer cytotoxic drugs and biologic inhibitors. These include in vitro cell-kill models and cytostatic dye exclusion tests as well as in vivo measurement of tumor growth parameters in laboratory animals.Dermatitis, Contact: A type of acute or chronic skin reaction in which sensitivity is manifested by reactivity to materials or substances coming in contact with the skin. It may involve allergic or non-allergic mechanisms.Drug Resistance: Diminished or failed response of an organism, disease or tissue to the intended effectiveness of a chemical or drug. It should be differentiated from DRUG TOLERANCE which is the progressive diminution of the susceptibility of a human or animal to the effects of a drug, as a result of continued administration.Catalysis: The facilitation of a chemical reaction by material (catalyst) that is not consumed by the reaction.Antimetabolites: Drugs that are chemically similar to naturally occurring metabolites, but differ enough to interfere with normal metabolic pathways. (From AMA Drug Evaluations Annual, 1994, p2033)Drug-Related Side Effects and Adverse Reactions: Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chemically-induced adverse conditions due to toxicity, DRUG INTERACTIONS, and metabolic effects of pharmaceuticals.Mites: Any arthropod of the subclass ACARI except the TICKS. They are minute animals related to the spiders, usually having transparent or semitransparent bodies. They may be parasitic on humans and domestic animals, producing various irritations of the skin (MITE INFESTATIONS). Many mite species are important to human and veterinary medicine as both parasite and vector. Mites also infest plants.Doxorubicin: Antineoplastic antibiotic obtained from Streptomyces peucetius. It is a hydroxy derivative of DAUNORUBICIN.United StatesNova Scotia: A province of eastern Canada, one of the Maritime Provinces with NEW BRUNSWICK; PRINCE EDWARD ISLAND; and sometimes NEWFOUNDLAND AND LABRADOR. Its capital is Halifax. The territory was granted in 1621 by James I to the Scotsman Sir William Alexander and was called Nova Scotia, the Latin for New Scotland. The territory had earlier belonged to the French, under the name of Acadia. (From Webster's New Geographical Dictionary, 1988, p871 & Room, Brewer's Dictionary of Names, 1992, p384)FloridaCell Survival: The span of viability of a cell characterized by the capacity to perform certain functions such as metabolism, growth, reproduction, some form of responsiveness, and adaptability.Isoquinolines: A group of compounds with the heterocyclic ring structure of benzo(c)pyridine. The ring structure is characteristic of the group of opium alkaloids such as papaverine. (From Stedman, 25th ed)Diterpenes: Twenty-carbon compounds derived from MEVALONIC ACID or deoxyxylulose phosphate.K562 Cells: An ERYTHROLEUKEMIA cell line derived from a CHRONIC MYELOID LEUKEMIA patient in BLAST CRISIS.Telephone: An instrument for reproducing sounds especially articulate speech at a distance. (Webster, 3rd ed)Insecticides: Pesticides designed to control insects that are harmful to man. The insects may be directly harmful, as those acting as disease vectors, or indirectly harmful, as destroyers of crops, food products, or textile fabrics.Benzimidazoles: Compounds with a BENZENE fused to IMIDAZOLES.HeLa Cells: The first continuously cultured human malignant CELL LINE, derived from the cervical carcinoma of Henrietta Lacks. These cells are used for VIRUS CULTIVATION and antitumor drug screening assays.Tumor Cells, Cultured: Cells grown in vitro from neoplastic tissue. If they can be established as a TUMOR CELL LINE, they can be propagated in cell culture indefinitely.Adverse Drug Reaction Reporting Systems: Systems developed for collecting reports from government agencies, manufacturers, hospitals, physicians, and other sources on adverse drug reactions.Vinblastine: Antitumor alkaloid isolated from Vinca rosea. (Merck, 11th ed.)Naphthoquinones: Naphthalene rings which contain two ketone moieties in any position. They can be substituted in any position except at the ketone groups.IsraelPopulation Surveillance: Ongoing scrutiny of a population (general population, study population, target population, etc.), generally using methods distinguished by their practicability, uniformity, and frequently their rapidity, rather than by complete accuracy.Environmental Exposure: The exposure to potentially harmful chemical, physical, or biological agents in the environment or to environmental factors that may include ionizing radiation, pathogenic organisms, or toxic chemicals.Stereoisomerism: The phenomenon whereby compounds whose molecules have the same number and kind of atoms and the same atomic arrangement, but differ in their spatial relationships. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)Cell Line: Established cell cultures that have the potential to propagate indefinitely.Arthropods: Members of the phylum Arthropoda, composed of organisms having a hard, jointed exoskeleton and paired jointed legs. It includes the class INSECTS and the subclass ARACHNIDA, many species of which are important medically as parasites or as vectors of organisms capable of causing disease in man.Ants: Insects of the family Formicidae, very common and widespread, probably the most successful of all the insect groups. All ants are social insects, and most colonies contain three castes, queens, males, and workers. Their habits are often very elaborate and a great many studies have been made of ant behavior. Ants produce a number of secretions that function in offense, defense, and communication. (From Borror, et al., An Introduction to the Study of Insects, 4th ed, p676)Aphidicolin: An antiviral antibiotic produced by Cephalosporium aphidicola and other fungi. It inhibits the growth of eukaryotic cells and certain animal viruses by selectively inhibiting the cellular replication of DNA polymerase II or the viral-induced DNA polymerases. The drug may be useful for controlling excessive cell proliferation in patients with cancer, psoriasis or other dermatitis with little or no adverse effect upon non-multiplying cells.Oligomycins: A closely related group of toxic substances elaborated by various strains of Streptomyces. They are 26-membered macrolides with lactone moieties and double bonds and inhibit various ATPases, causing uncoupling of phosphorylation from mitochondrial respiration. Used as tools in cytochemistry. Some specific oligomycins are RUTAMYCIN, peliomycin, and botrycidin (formerly venturicidin X).Hospitalization: The confinement of a patient in a hospital.Cell Cycle Proteins: Proteins that control the CELL DIVISION CYCLE. This family of proteins includes a wide variety of classes, including CYCLIN-DEPENDENT KINASES, mitogen-activated kinases, CYCLINS, and PHOSPHOPROTEIN PHOSPHATASES as well as their putative substrates such as chromatin-associated proteins, CYTOSKELETAL PROTEINS, and TRANSCRIPTION FACTORS.DNA, Superhelical: Circular duplex DNA isolated from viruses, bacteria and mitochondria in supercoiled or supertwisted form. This superhelical DNA is endowed with free energy. During transcription, the magnitude of RNA initiation is proportional to the DNA superhelicity.Information Services: Organized services to provide information on any questions an individual might have using databases and other sources. (From Random House Unabridged Dictionary, 2d ed)Referral and Consultation: The practice of sending a patient to another program or practitioner for services or advice which the referring source is not prepared to provide.Biological Transport, Active: The movement of materials across cell membranes and epithelial layers against an electrochemical gradient, requiring the expenditure of metabolic energy.Gas Chromatography-Mass Spectrometry: A microanalytical technique combining mass spectrometry and gas chromatography for the qualitative as well as quantitative determinations of compounds.Adenosine Triphosphate: An adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.CaliforniaMutation: Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.Cricetinae: A subfamily in the family MURIDAE, comprising the hamsters. Four of the more common genera are Cricetus, CRICETULUS; MESOCRICETUS; and PHODOPUS.Drug Synergism: The action of a drug in promoting or enhancing the effectiveness of another drug.Predatory Behavior: Instinctual behavior pattern in which food is obtained by killing and consuming other species.Triage: The sorting out and classification of patients or casualties to determine priority of need and proper place of treatment.Substance Abuse Detection: Detection of drugs that have been abused, overused, or misused, including legal and illegal drugs. Urine screening is the usual method of detection.Protein-Serine-Threonine Kinases: A group of enzymes that catalyzes the phosphorylation of serine or threonine residues in proteins, with ATP or other nucleotides as phosphate donors.
Drug induced liver disease. Drug induced liver damage. Drug induced liver injury. Hepatogenous poisoning ... Toxin induced hepatitis. Drug induced hepatitis. Drug-induced hepatic necrosis. Drug induced hepatic fibrosis. Drug induced ... Drug-induced liver injury is responsible for 5% of all hospital admissions and 50% of all acute liver failures. ... Patterns of drug-induced liver disease Type of injury:. Hepatocellular. Cholestatic. Mixed ...
The incidence of drug-induced parkinsonism increases with age. Drug-induced parkinsonism tends to remain at its presenting ... Poisoning & Drug Overdose. 6th ed. New York: McGraw-Hill; 2012. http://www.accessmedicine.com/content.aspx?aID=55982958. ... Drug-induced. About 7% of people with parkinsonism developed symptoms as a result of side effects of medications, mainly ... "Information Sheet: Drug-induced Parkinsonism" (PDF). Parkinson's Disease and Society. Archived from the original (PDF) on 2013- ...
Radiation-induced erythema multiforme. Radiation-induced hypertrophic scar. Radiation-induced keloid. Radiation-induced morphea ... Radiation poisoning. Radiation burn. Chronic radiation keratosis. Eosinophilic, polymorphic, and pruritic eruption associated ... Abortion, miscarriage or uterine hemorrhage associated with misoprostol (Cytotec), a labor-inducing drug (this is a case where ... Kraus MR, Schäfer A, Schöttker K, Keicher C, Weissbrich B, Hofbauer I, Scheurlen M (April 2008). "Therapy of interferon-induced ...
First aid kit
Rabbits also can succumb to chocolate poisoning. Theobromine is known to induce gene mutations in lower eukaryotes and bacteria ... If caught early on, theobromine poisoning is treatable. Although not common, the effects of theobromine poisoning can be fatal ... Theobromine poisoning may result from the chronic or acute consumption of large quantities, especially in the elderly. ... We also demonstrate that theobromine directly inhibits capsaicin-induced sensory nerve depolarization of guinea-pig and human ...
Death from arsenic poisoning typically occurs within a day. Antimony is mildly toxic. Additionally, wine steeped in antimony ... containers can induce vomiting. When taken in large doses, antimony causes vomiting in a victim, who then appears to recover ... Only one person has ever been reported to have died from bismuth poisoning. However, consumption of soluble bismuth salts can ...
Lin CC, Chan TY, Deng JF (May 2004). "Clinical features and management of herb-induced aconitine poisoning". Ann Emerg Med. 43 ... Successful use of charcoal hemoperfusion has been claimed in patients with severe aconite poisoning. Poisoning may also occur ... All parts of this plant are extremely toxic, and it has historically been used as a poison on arrows. If not prepared properly ... Treatment of poisoning is mainly supportive. All patients require close monitoring of blood pressure and cardiac rhythm. ...
Clostridial necrotizing enteritis
Lin CC, Chan TY, Deng JF (May 2004). "Clinical features and management of herb-induced aconitine poisoning". Ann Emerg Med. 43 ... Successful use of charcoal hemoperfusion has been claimed in patients with severe aconite poisoning. Poisoning may also occur ... Treatment of poisoning is mainly supportive. All patients require close monitoring of blood pressure and cardiac rhythm. ... Treatment is similar to poisoning caused by oral ingestion. Aconitine is a potent neurotoxin that opens ...
Lin CC, Chan TY, Deng JF (May 2004). "Clinical features and management of herb-induced aconitine poisoning". Ann Emerg Med. 43 ... Successful use of charcoal hemoperfusion has been claimed in patients with severe aconite poisoning. Poisoning may also occur ... A. napellus has a long history of use as a poison, with cases going back thousands of years. During the ancient Roman period of ... Arrow poisons in China. Part II. Aconitum--botany, chemistry, and pharmacology. Bisset NG. "Toxicology in the Old Testament: ...
Several deaths reported as MDMA-induced in Australia in the mid-1990s are now considered to have been caused by PMA, the users ... PMA is considered a Schedule 9 prohibited substance in Australia under the Poisons Standard (October 2015). A Schedule 9 ... There have been a number of PMA-induced deaths around the world since then. In July 2013, seven deaths in Scotland were linked ... Lamberth PG, Ding GK, Nurmi LA (April 2008). "Fatal paramethoxy-amphetamine (PMA) poisoning in the Australian Capital Territory ...
Likewise, poisoning due to other alcohols such as ethylene glycol or diethylene glycol are due to their metabolites, which are ... Ozaras R, Tahan V, Aydin S, Uzun H, Kaya S, Senturk H (2003). "N-acetylcysteine attenuates alcohol-induced oxidative stress in ... "What's your poison" (PDF). New Scientist. Archived from the original on 21 February 2012. Retrieved 10 February 2007. Maxwell ... Brent J (May 2009). "Fomepizole for ethylene glycol and methanol poisoning". N. Engl. J. Med. 360 (21): 2216-23. doi:10.1056/ ...
Runoff can also induce heavy metal poisoning in ocean life. Small amounts of heavy metals are carried by runoff into the oceans ... This heavy metal poisoning can also affect humans. If we eat a poisoned animal, we have a chance of getting heavy metal ... poisoning too. As stormwater is channeled into storm drains and surface waters, the natural sediment load discharged to ...
Ethanol-induced hypoglycemia. Ethanol is dehydrogenated to acetaldehyde by alcohol dehydrogenase, and further into acetic ... Therefore, anion-gap metabolic acidosis (lactic acidosis) may ensue in ethanol poisoning. ... Robergs RA, Ghiasvand F, Parker D (2004). "Biochemistry of exercise-induced metabolic acidosis". Am J Physiol Regul Integr Comp ...
Death of Gertrude Hullett
Moreover, her breathing was shallow; typical of an overdose-induced coma. On 21 July, a pathologist by the name of Dr Shera was ... Dr Harris visited again that day and Adams still made no mention of potential barbiturate poisoning. When Harris left, Adams ... This, however, is also a symptom of morphine or barbiturate poisoning. ... at the Princess Alice Hospital in Eastbourne and asked about the treatment for barbiturate poisoning. He was told to give doses ...
Tumor necrosis factor alpha
TRAF2/Rac activates the JNK-inducing upstream kinases of MLK2/MLK3, TAK1, MEKK1 and ASK1 (either directly or through GCKs ... They then identified TNF as a mediator of lethal endotoxin poisoning. Kevin J. Tracey and Cerami discovered the key ... Its death-inducing capability is weak compared to other family members (such as Fas), and often masked by the anti-apoptotic ... death-inducing signaling complex assembly. • regulation of osteoclast differentiation. • defense response to bacterium. • ...
The rash that develops from poison ivy, poison oak, and poison sumac contact is commonly mistaken for urticaria. This rash is ... Drug-induced hives has been known to have an effect on severe cardiorespiratory failure.[medical citation needed] The most ... Jogging is the most common exercise to cause EU, but it is not induced by a hot shower, fever, or with fretfulness. This ... The occurrence of drug-induced solar urticaria may be associated with porphyrias. This may be caused by IgG binding, not IgE. ...
Skin and eye irritant, can induce lead poisoning by ingestion or inhalation. Symptoms include gastrointestinal disorders, ... Since Lead poisoning occurs with the binding of Lead (II) to biological systems, research has been done to find ligands that ... Lead thiocyanate can cause lead poisoning if ingested and can adversely react with many substances. It has use in small ... more preferentially bind to Lead (II) than other biological targets in an effort to combat the effects of lead poisoning. ...
Effects of long-term benzodiazepine use
Drug-induced symptoms that resemble withdrawal-like effects can occur on a set dosage as a result of prolonged use, also ... Klein-Schwartz W, Oderda GM (January 1991). "Poisoning in the elderly. Epidemiological, clinical and management considerations ... The mental health and physical health symptoms induced by long-term benzodiazepine use gradually improved significantly over a ... Long-term use of benzodiazepines can induce perceptual disturbances and depersonalisation in some people, even in those taking ...
An induced nuclear fission event. A neutron is absorbed by the nucleus of a uranium-235 atom, which in turn splits into fast- ... These systems insert large amounts of poison (often boron in the form of boric acid) into the reactor to shut the fission ... Control rods are made of neutron poisons and therefore tend to absorb neutrons. When a control rod is inserted deeper into the ... In other reactors the coolant acts as a poison by absorbing neutrons in the same way that the control rods do. In these ...
Emesis (i.e. induced by ipecac) is no longer recommended in poisoning situations, because vomiting is ineffective at removing ... Poisoning. Main article: Poisoning. Acute poisoning is exposure to a poison on one occasion or during a short period of ... The term "poison ivy", for example, was first used in 1784 and the term "poison oak" was first used in 1743. The term "poison ... Two common cases of acute natural poisoning are theobromine poisoning of dogs and cats, and mushroom poisoning in humans. Dogs ...
The rash that develops from poison ivy, poison oak, and poison sumac contact is commonly mistaken for urticaria. This rash is ... Drug-induced hives has been known to have an effect on severe cardiorespiratory failure.[medical citation needed] ... Dietary histamine poisoningEdit. This is termed scombroid food poisoning. Ingestion of free histamine released by bacterial ... Cold-inducedEdit. Further information: Cold urticaria. The cold type of urticaria is caused by exposure of the skin to extreme ...
P53 upregulated modulator of apoptosis
Other agents that induce p53 dependent apoptosis are neurotoxins, proteasome inhibitors, microtubule poisons, and transcription ... Inhibiting PUMA induced apoptosis may be an interesting target for reducing the side effects of cancer treatments, such as ... Various studies have shown though, that PUMA does not rely on direct interaction with Bax/Bak to induce apoptosis. The majority ... In addition, studies have shown that PUMA adenovirus seems to induce apoptosis more so than p53 adenovirus. This is beneficial ...
European fire-bellied toad
The skin produces a poison to protect itself from bacteria and fungi or the animal from vertebrates. This poison is irritating ... Reproduction takes place from April to July/August and is induced by heavy rainfall. Then, males can be recognized by some ... The combination of dark and red is a learned signal meaning "attention poison" to the enemy. ...
Mitchell, T (2009). "Intravenous Milk thistle (silibinin-legalon) for hepatic failure induced by Amanita mushroom poisoning". ( ... Mushroom poisoning Antibody-drug conjugate H. Hallen; H. Luo; J.S. Scott-Craig; J.D. Walton (2007). "A gene family encoding the ... in: Mushrooms: poisons and panaceas - a handbook for naturalists, mycologists and physicians. New York: WH Freeman and Company ... Around 15% of those poisoned will die within 10 days, progressing through a comatose stage to kidney failure, liver failure, ...
These drugs are efficient for acute poisoning of arsenic, which refers to the instantaneous effects caused by arsenic poisoning ... Bau, D.T; Wang, T.S (2002). "Oxidative DNA adducts and DNA-protein cross-links are the major DNA lesions induced by arsenite". ... Poisoning with arsenic can raise lactate levels and lead to lactic acidosis. Genotoxicity involves inhibition of DNA repair and ... On the other hand, the unfolded proteins are corrected by the production of chaperones, which are induced by the activating ...
Myristicin poisoning can induce convulsions, palpitations, nausea, eventual dehydration, and generalized body pain.[citation ... Stein, U.; Greyer, H.; Hentschel, H. (2001). "Nutmeg (myristicin) poisoning--report on a fatal case and a series of cases ... and essential oils as irritant or toxic defense mechanisms that repel or poison many herbivorous organisms. The wood is pink to ... recorded by a poison information centre". Forensic Science International. 118 (1): 87-90. doi:10.1016/S0379-0738(00)00369-8. ...
If poisoning a subject is not necessary, it can bite without excreting the venom. When the snake does use it, it mostly tries ... The cause of this disease is still unknown but there is a possible chance that the disease is induced or worsened by viral ... Although cobratoxin is a relatively toxic and dangerous poison it also has a beneficial side. It is a natural and biological ... These rediocides bind at the same nicotinic acetylcholine receptor as the snake poison does. Because a number of the binding ...
Incidents of heavy metal poisoning have been attributed to the use of these compounds in the United States. ... Such disease-inducing imbalances can be adjusted and balanced using traditional herbs, minerals and heavy metals. Ayurveda ... "Biology-based" as coined by NCCIH may refer to chemicals from a nonbiological source, such as use of the poison lead in ... cyanide poisoning from amygdalin, or the intentional ingestion of hydrogen peroxide) or actively interfere with effective ...
Leiner Health Products
Chemotherapy induced nausea and vomitingEdit. Further information: Chemotherapy-induced nausea and vomiting and Aprepitant ... In line with its role as a first line defense system, SP is released when toxicants or poisons come into contact with a range ... SP can induce the cytokines that are capable of inducing NK-1 transcription factors. ... Substance P-induced vasodilatation is dependent on nitric oxide release. Substance P is involved in the axon reflex- ...
Occupational health psychology
"Beluga Whales in Captivity: Hunted, Poisoned, Unprotected". Special Report on Captivity 2006. Canadian Marine Environment ... "Quantifying the sensitivity of Arctic marine mammals to climate-induced habitat change" (PDF). Ecological Applications. 18 (2 ... They can also be poisoned by swallowing litter, such as plastic bags. Advanced military sonar harms whales. Sonar ...
Inside the endosome, the decreased pH induces the fusion of the endosomal membrane with the virus envelope. The capsid enters ... "The mosquito hypothetically considered as an agent in the transmission of yellow fever poison," Archived 2017-02-23 at the ... virus-induced apoptosis in hepatocytes associated with TGF-beta, TNF-alpha and NK cells activity". Virology. 345 (1): 22-30. ...
... consumption induces mild euphoria and excitement, similar to that conferred by strong coffee. Individuals become very ... Bentur, Y.; Bloom-Krasik, A.; Raikhlin-Eisenkraft, B. (2008). "Illicit cathinone ("Hagigat") poisoning". Clinical Toxicology. ... Khat can induce manic behaviours and hyperactivity, similar in effects to those produced by amphetamine. ...
In 1913, Antarctic explorers Douglas Mawson and Xavier Mertz were both poisoned (and Mertz died) from eating the livers of ... Nollevaux MC, Guiot Y, Horsmans Y, Leclercq I, Rahier J, Geubel AP, Sempoux C (March 2006). "Hypervitaminosis A-induced liver ... Rothenberg AB, Berdon WE, Woodard JC, Cowles RA (December 2007). "Hypervitaminosis A-induced premature closure of epiphyses ( ... "Histological disorders related to the focal disappearance of the epiphyseal growth plate in rats induced by high dose of ...
Invaded ecosystems may have experienced disturbance, typically human-induced. Such a disturbance may give invasive species ... are alive in ballast discharge and get released into their "new environment" they could cause domoic acid poisoning in ... Due to the complexity of climate change induced variations, it is difficult to predict the nature of temperature-based success ... shellfish, marine mammals and birds. Fortunately, human deaths related to domoic acid poisoning have been prevented because ...
PoisoningEdit. Rarely, blindness is caused by the intake of certain chemicals. A well-known example is methanol, which is only ... corticosteroid-induced; and 4) a heterogonous mechanism associated with structural change and chronic inflammation. In ... "Symptoms of Methanol Poisoning. Canada Safety Council. 2005. Archived from the original on 20 February 2007. Retrieved 27 March ...
Edward I of England
Although he managed to kill the assassin, he was struck in the arm by a dagger feared to be poisoned, and became severely ... In 1254, English fears of a Castilian invasion of the English province of Gascony induced Edward's father to arrange a ... The anecdote of Queen Eleanor saving Edward's life by sucking the poison out of his wound is almost certainly a later ... who attempted to suck the poison from the wound. ...
Among cyanotoxins are some of the most powerful natural poisons known, including poisons which can cause rapid death by ... The toxin was called the Very Fast Death Factor because it induced tremors, paralysis and death within a few minutes when ... a number of sea otters were poisoned by microcystin. Marine bivalves were the likely source of hepatotoxic shellfish poisoning ... Stewart I, Seawright AA, Shaw GR (2008). Cyanobacterial poisoning in livestock, wild mammals and birds - an overview (PDF). ...
Conservatism in the United States
They also cannot be buried or run along or attached to anything conductive, as the extended fields will induce currents in the ... cabling gives off poison gas when burned. ... is sometimes used to mitigate the effect of currents induced in ... and they can be strapped to conductive supports without inducing unwanted currents in them. ...
a b Salo, P., Nordström, M., Thomson, R. L., & Korpimäki, E. (2008). Risk induced by a native top predator reduces alien mink ... Since their reintroduction seven eagles have been confirmed poisoned in County Kerry, two suspected of having been poisoned, ... Kim, E. Y., Goto, R., Iwata, H., Masuda, Y., Tanabe, S., & Fujita, S. (1999). Preliminary survey of lead poisoning of Steller's ... However, Dr Allan Mee, in charge of the sea eagle project, stated "the continuing loss of eagles to poisoning had cast a shadow ...
In medicine, diuretics are used to treat heart failure, liver cirrhosis, hypertension, influenza, water poisoning, and certain ... "Characterization of the antihypertensive effect of a thiazide diuretic in angiotensin II-induced hypertension". Journal of ... the urine more alkaline and are helpful in increasing excretion of substances such as aspirin in cases of overdose or poisoning ...
Prolonged hypoxia induces neuronal cell death via apoptosis, resulting in a hypoxic brain injury. ... Anemia and carbon monoxide poisoning are common causes of hypemic hypoxia.. *Ischemic hypoxia ( or "stagnant hypoxia") - ... Nov 2001). "Hypoxia induces apoptosis via two independent pathways in Jurkat cells: differential regulation by glucose". ... Recent research suggests this may be due to an autoimmune response caused by carbon monoxide-induced changes in the myelin ...
Rats may also emit short, high frequency, ultrasonic, socially induced vocalization during rough and tumble play, before ... and poisoned 147 rats in the landfill, and no live rats were found thereafter. In 2013, the number of rat infestations in ... poisoning, and gassing rats, and bulldozing or burning down some rat-infested buildings. The effort was backed by legislation ...
Staphylococcal scalded skin syndrome
Obstructive sleep apnea
ICD-10 Chapter V: Mental and behavioural disorders
F05) Delirium, not induced by alcohol and other psychoactive substances. *(F06) Other mental disorders due to brain damage and ... Injury, poisoning and certain other consequences of external causes XX V01-Y98 External causes of morbidity and mortality ... F04) Organic amnesic syndrome, not induced by alcohol and other psychoactive substances ...
Contributory factors in herb-induced fatal aconite poisoning.
Detailed investigations of all reported cases of herb-induced aconite poisoning are necessary to identify the major ... Detailed investigations of all reported cases of herb-induced aconite poisoning are necessary to identify the major ... of processed aconite roots during decoction preparation were important contributory factors in herb-induced aconite poisoning. ...
Intravenous Milk Thistle (Silibinin-Legalon) for Hepatic Failure Induced by Amatoxin/Amanita Mushroom Poisoning - Full Text...
Amatoxin Poisoning Amanita Poisoning Mushroom Poisoning Liver Failure Drug: Silibinin Phase 2 Phase 3 ... Poisoning. Mushroom Poisoning. Hepatic Insufficiency. Liver Diseases. Digestive System Diseases. Chemically-Induced Disorders. ... Intravenous Milk Thistle (Silibinin-Legalon) for Hepatic Failure Induced by Amatoxin/Amanita Mushroom Poisoning. The safety and ... Liver function tests suggestive of amatoxin poisoning: AST or ALT above the upper limit of normal within 48 hrs after mushroom ...
Cellular Responses to DNA Damage Induced by Topoisomerase Poisons - Anticancer Drug Action: Scott H. Kaufmann - Mayo Clinic...
Cellular Responses to DNA Damage Induced by Topoisomerase Poisons. ... Cellular Responses to DNA Damage Induced by Topoisomerase Poisons. The Anticancer Drug Action Lab is studying cellular ... responses to DNA damage induced by topoisomerase poisons.. DNA topoisomerase I is an abundant nuclear enzyme that adjusts the ... This unique reagent is being applied in preclinical and clinical studies to determine whether the stabilization of drug-induced ...
Intravenous Milk Thistle (Silibinin-Legalon) for Hepatic Failure Induced by Amatoxin/Amanita Mushroom Poisoning | Clinical...
Mushroom Poisoning , Amatoxin Poisoning , Intravenous Milk Thistle (Silibinin-Legalon) for Hepatic Failure Induced by Amatoxin/ ... Intravenous Milk Thistle (Silibinin-Legalon) for Hepatic Failure Induced by Amatoxin/Amanita Mushroom Poisoning Brief ... Patients with suspected amatoxin poisoning are reviewed for enrollment in the study by contacting the Legalon SIL study hotline ... Legalon SIL will be administered to patients with amatoxin poisoning diagnosed by history, gastrointestinal symptoms, elevated ...
Method for Inducing Protection in Animal Against Cyanide Poisoning Using 8-Aminoquinolines.
... at sufficient levels to afford post-or pretreatment of said animals against poisoning resulting from exposure to toxic levels ... present invention avoids many problems associated with previously known treatments by orally administering a compound to induce ... This invention relates to novel means for inducing the production of blood methemoglobin in animals, ... Title : Method for Inducing Protection in Animal Against Cyanide Poisoning Using 8-Aminoquinolines. ...
Atorvastatin attenuates paraquat poisoning-induced epithelial-mesenchymal transition via downregulating hypoxia-inducible...
ATS alleviated PQ poisoning-induced lung injury and pulmonary fibrosis in vivo. This effect was dose-dependent. ATS treatment ... Atorvastatin attenuates paraquat poisoning-induced epithelial-mesenchymal transition via downregulating hypoxia-inducible ... ATS may be considered as a therapeutic agent for PQ poisoning-induced pulmonary fibrosis. ... The mechanism may involve the downregulation of the HIF-1α/β-catenin pathway and the inhibition of the PQ-induced EMT by ATS. ...
DIGITAL.CSIC: Man-induced activities modify demographic parameters in a long-lived species: Effects of poisoning and health...
Man-induced activities modify demographic parameters in a long-lived species: Effects of poisoning and health policies. ... As a result, supplementary feeding as a precautionary measure can be a useful tool to reduce illegal poisoning and declines in ... such as illegal poisoning, are threatening European vultures. However, the effects of anthropogenic activities on demographic ... of specific supplementary feeding stations for Bearded Vultures probably reduced the negative effects of illegal poisoning and ...
Can we improve prognostic indications in acetaminophen-induced hepatic failure? » The Poison Review
Can we improve prognostic indications in acetaminophen-induced hepatic failure?. February 9, 2018, 4:13 pm. ... The standard tool used in evaluating acetaminophen-poisoned patients for possible orthotopic liver transplantation (OLT) is the ... admitted to hospital and discharged with a diagnosis of acetaminophen-induced liver failure. The objective was to compare the ...
In vivo effects of a novel calcium antagonist (R56865) against induced epoxyscillirosidin and tulp poisoning in sheep
... Login ... In vivo effects of a novel calcium antagonist (R56865) against induced epoxyscillirosidin and tulp poisoning in sheep. en. ... against induced epoxyscillirosidin and tulp poisoning in sheep. Onderstepoort Journal of Veterinary Research, vol. 62, no. 3, ... The results of this study indicate that the in vivo response of R56865 against induced bufadienolide cardiac disturbance in ...
In vivo effects of a novel calcium antagonist (R56865) against induced epoxyscillirosidin and tulp poisoning in sheep
... Login ... In vivo effects of a novel calcium antagonist (R56865) against induced epoxyscillirosidin and tulp poisoning in sheep. Swan, ... The results of this study indicate that the in vivo response of R56865 against induced bufadienolide cardiac disturbance in ... another two conscious sheep were poisoned by intraruminal dosing of 1,25 g/kg of dried H. pallida plant material. ...
Coma: Click for Facts About Induced Coma & Other Coma Types
... or poisoning, including alcohol poisoning. Depth of coma is measured by the Glasgow Coma Scale. ... Poisoning or inflammation of the brain can cause coma with loss of function of both cerebral hemispheres. Trauma is another ... There are two sources of poisons that can affect the brain, those that we take into the body (through ingestion or inhaling), ... Alcohol is probably the most common cause of ingested poison or toxin, leading to altered mental status and coma. In acute ...
Food poisoning more likely in restaurants than home | Fox News
Americans who eat out at restaurants are twice as likely to get food poisoning, compared to those who eat food prepared at home ... What is norovirus? 2018 Winter Olympics plagued by vomit-inducing bug * 2 Brave baby survives open-heart surgery at 1-week old ... Food poisoning more likely in restaurants than home. Published April 11, 2014. Fox News ... Americans who eat out at restaurants are twice as likely to get food poisoning, compared to those who eat food prepared at home ...
Rad18 is required for functional interactions between FANCD2, BRCA2, and Rad51 to repair DNA topoisomerase 1-poisons induced...
... and Rad51 to repair DNA topoisomerase 1-poisons induced lesions and promote fork recovery ... Rad18 is required for functional interactions between FANCD2, BRCA2, and Rad51 to repair DNA topoisomerase 1-poisons induced ... BRCA2 and Rad51 in repair of Top1-poisons-induced DSB. In this model Rad18 acts first in this repair complex and promotes ... and Stewart L. The mechanism of topoisomerase I poisoning by a camptothecin analog. Proc. Natl. Acad. Sci. U. S. A. 2002 99. ...
Tylenol Poisoning: Acetaminophen Overdose Symptoms & Treatment
Poisoning symptoms include vomiting, nausea, poor appetite, and not feeling well. Acetaminophen (Tylenol) poisoning can lead to ... Drug-Induced Liver Disease. Drug-induced liver diseases are diseases of the liver that are caused by physician-prescribed ... The eMedicineHealth doctors ask about Acetaminophen Poisoning (Tylenol):. Acetaminophen (Tylenol) Poisoning - Symptoms. What ... If the person is awake and breathing without symptoms, call a local poison control center or the American Association of Poison ...
Frequently Asked Questions · MN Poison Control System
When should I induce vomiting?. *You should ALWAYS consult your physician or the Poison Center to determine if vomiting is ... What if I suspect someone has been poisoned?. *If you suspect you or someone else has been poisoned, call the Poison Center at ... When is the Poison Center the busiest?. *The busiest time for the Poison Center is during the summer months since children play ... What is a poison?. *A poison is any potentially harmful substance taken into, or applied to the body. ...
Winter health hazards
Snow shoveling-induced heart attack. A study published in 2010 in the journal Lancet found a scary trend: Heavy snowfall, cold ... Carbon monoxide poisoning. Carbon monoxide is a colorless, odorless gas that can build up from a faulty furnace or from using ... There are a number of things you can do to prevent the potential for poisoning. Have your heating system serviced regularly. ... approximately 170 people die each year from carbon monoxide poisoning. ...
Lead Poisoning, Nervous System, Childhood; Lead Encephalopathy, Childhood; Lead Poisoning, Neurologic, Childhood; Lead-Induced...
Lead-Induced Nervous System Disease, Childhood; Nervous System Disease, Lead-Induced, Childhood; Nervous System Poisoning, Lead ... Poisoning, Lead, Nervous System, Childhood; Poisoning, Lead, Neurologic, Childhood. On-line free medical diagnosis assistant. ... Lead Poisoning, Nervous System, Childhood; Lead Encephalopathy, Childhood; Lead Poisoning, Neurologic, Childhood; ... Lead Poisoning, Nervous System, Childhood (Lead Encephalopathy, Childhood; Lead Poisoning, Neurologic, Childhood; Lead-Induced ...
3 Ways to Treat Poisoning - wikiHow
Poisoning can occur when someone swallows something toxic, spills or splashes a dangerous substance on their skin or eyes, or ... Never induce vomiting unless a doctor or poison control specialist tells you to. Forcing someone who has been poisoned to throw ... The symptoms of poisoning vary depending on the type of poison. Most poisoning happens when someone eats or drinks a poisonous ... Never induce vomiting unless a medical expert tells you to. Making a person vomit when they have swallowed poison could cause ...
Wilderness: Clupeotoxin Poisoning
Clupeotoxin poisoning occurs in humans who eat plankton-eating fish contaminated with this tasteless, odorless toxin; symptoms ... Clupeotoxin Poisoning Treatment. *Do not induce vomiting.. *Maintain hydration. Intravenous fluids may be necessary for ... wilderness: clupeotoxin poisoning, clupeotoxin poisoning, toxin, poison, clupeotoxin fish poisoning, fish poison ... The poison does not break down when the fish is cooked.. Clupeotoxin Poisoning Symptoms. *Symptoms of clupeotoxin poisoning ...
Wilderness: Shellfish Poisoning, Paralysis
Shellfish poisoning can occur after eating clams, mussels, oysters, scallops, cockles, starfish, and crustaceans that consume ... Shellfish Poisoning Paralysis Treatment. *Do not induce vomiting. *In case of vomiting, turn the person on his or her side to ... Wilderness: Shellfish Poisoning, Paralysis. In this Article. In this Article In this Article * Shellfish Poisoning Paralysis ... Shellfish Poisoning Paralysis Symptoms. Symptoms of shellfish poisoning begin 30 minutes to 2 hours after eating and include:. ...
Dog Owner's Guide: Intestinal upsets
Poisoning: Inducing vomiting. Plant and product poisoning can kill or cause serious illness, so contact your veterinarian or ... More on the National Poison Control Center]. In some cases of poisoning, vomiting should be induced to get the toxin out of the ... Poisoning: Inducing vomiting Introduction. Grumbling guts, vomiting, and diarrhea are common problems in dogs that have a ... If it says do not induce vomiting, pay attention.). Norma Bennett Woolf. This page is a part of the Dog Owners Guide internet ...
Poison in Nature
For the most part, when humans are stung or poisoned, weve been caught in the crossfire. ... Poisons are just one tool of many in an organisms struggle for existence. ... Some venom components might induce pain; others may home in on the clotting factors of blood, on cell membranes, or on the ... POISON: BATRACHOTOXIN. What is it? The poison found in the skin of golden poison frogs, batrachotoxin (bah-TRAY-ko-tox-in) gets ...
Uranium Poisoning | GreenMedInfo | Disease | Natural Medicine
Diseases : Chemically-Induced Liver Damage, Kidney Damage: Drug-Induced, Liver Damage: Drug-Induced, Oxidative Stress, Uranium ... Uranium Poisoning is a Sub of the following Topic. *Radiation Disaster Associated Toxicity ... Despite the relatively low specific activity of depleted uranium as a radiogenic substance, it is capable of inducing cancer at ... Ginkgo biloba has a protective effect against uranium-induced liver and kidney damage in mice.Feb 01, 2010. ...
Tin Poisoning | GreenMedInfo | Disease | Natural Medicine
This topic contains 7 study abstracts on Tin Poisoning indicating that the following substances may be helpful: Vitamin C, ... Stannous chloride (tin) induces adverse changes in enzyme activities, lipid peroxidation and histopathology in the male rabbit ... 7 Abstracts with Tin Poisoning Research. Filter by Study Type. Animal Study. ... Devils claw (H. procumbens) protects against stannous chloride (tin) induced cytotoxicity. Jan 01, 2007. ...
Magnesium and Thermite Poisoning Medication: Gases, Electrolytes, Topical burn treatment, Topical antibiotics, Immunizing...
Used to induce active immunity.. Immunizing agents of choice for most adults and children ,7 y are tetanus and diphtheria ... encoded search term (Magnesium and Thermite Poisoning) and Magnesium and Thermite Poisoning What to Read Next on Medscape. ... Magnesium and Thermite Poisoning Medication. Updated: Sep 08, 2015 * Author: Jayson Tappan, MD; Chief Editor: Zygmunt F Dembek ...
Mushroom Poisoning Syndromes - North American Mycological Association
Other Alcohol Induced Syndromes. Mushrooms: Coprinus comatus, Clitocybe clavipes, Boletus luridus, Morels, Pholiota squarrosa, ... In a mushroom poisoning emergency…. Contact your nearest poison control center in the US or Canada, emergency room, or your ... Mushroom Poisoning Syndromes. There are many different types of mycotoxins. Of 14 distinctive types of mushroom poisoning found ... Simply handling mushrooms can on rare occasion cause a rash and itching similar to reaction to poison oak and poison ivy in ...
Mannitol (Osmitrol) Drug Information - Indications, Dosage, Side Effects and Precautions
New Hepatitis B Vaccine Studies Show Disastrous Results from Vaccinating All Newborns - Monitoring the Planned Poisoning of...
Vaccine-induced versus natural immunity. As noted, the WHO has strongly promoted universal HepB vaccination and particularly ... This is because the measles vaccine "induces lower antibody levels than does natural infection and the antibody levels of ... they found that vaccine-induced protection waned rapidly and significantly, falling from 82% of under-one-year-olds to 47% of ...
Arsenic poisoning | Britannica.com
Arsenic poisoning, harmful effects of various arsenic compounds on body tissues and functions. Arsenicals are used in numerous ... atrophy: Chemical-induced atrophy. In chronic arsenic poisoning, however, degenerative changes occur in peripheral nerves, ... Poisoning may result from a single large dose (acute poisoning) or from repeated small doses (chronic poisoning). Symptoms of ... Among industrial workers, arsine may be a source of accidental poisoning. Poisoning may also result from prolonged treatment ...
Effects of legislation restricting pack sizes of paracetamol and salicylate on self poisoning in the United Kingdom: before and...
Serial prothrombin time as a prognostic indicator in paracetamol induced fulminant hepatic failure. BMJ 1990; 301: 964-966. ... Liver transplant rates after paracetamol poisoning decreased by 66% (55% to 74%). The rate of non-fatal self poisoning with ... on all presentations with self poisoning between 16 September 1997 and 15 September 1999. Figures for self poisoning with ... Non-fatal self poisoning. These trends were also reflected in a reduction in the number and proportion of overdoses in which ...
WikipediaTOXICITYAccidentalAcetaminophenToxinHumansIngestionSelf poisoning with pSeizureDiagnosisCyanideIntravenousSymptoms of ciguateraDeaths from paracetamolComaToxinsFood PoisoningRatsPatientsHepatotoxicityCarbonPoisoningsToxicVentricular FibrillationDiseaseArsenicEXPOSUREMechanismPhysician or poison-controAconiteTreatmentCentersIllnessCardiacLead PoisoningLipid peroxidationMushroom PoisoningTopoisomerasePreventionSyrupAllergic reactionApoptosisSymptomaticOxidative stressDiseasesHotlineCocaine-inducedSeizuresNearest poison controPulmonary
- Hepatotoxicity and drug-induced liver injury also account for a substantial number of compound failures, highlighting the need for drug screening assays, such as stem cell -derived hepatocyte-like cells, that are capable of detecting toxicity early in the drug development process. (wikipedia.org)
- Nitric oxide also plays a role in inducing toxicity. (wikipedia.org)
- Neuro-Protective Effects of Resveratrol on Carbon Monoxide-Induced Toxicity in Male Rats. (nih.gov)
- Arsenic Toxicity: How Does Arsenic Induce Pathogenic Change? (cdc.gov)
- Deliberate or accidental poisoning with large doses of medication or drugs is often accompanied by alcohol use, but they might also be using harder drugs. (wikihow.com)
- Among industrial workers, arsine may be a source of accidental poisoning. (britannica.com)
- Main outcome measures Suicide, deaths of undetermined intent, and accidental poisoning deaths involving single drug ingestion of paracetamol and paracetamol compounds in people aged 10 years and over, and liver unit registrations and transplantations for paracetamol induced hepatotoxicity. (bmj.com)
- A similar effect was found when accidental poisoning deaths were included, and when a conservative method of analysis was used. (bmj.com)
- In many countries, self poisoning with paracetamol (acetaminophen) is a common method of suicide and non-fatal self harm, it is responsible for many accidental deaths, and is a frequent cause of hepatotoxicity and liver unit admissions. (bmj.com)
- Winder describes a death from accidental carbon monoxide poisoning caused by burning charcoal briquettes as a heat source indoors. (mja.com.au)
- see Box ) of accidental carbon monoxide poisoning from burning charcoal in enclosed spaces since 2004: three cases in 2004, none in 2005, eight in 2006, one in 2007, none in 2008, seven in 2009, four in 2010, 18 in 2011, and five in 2012. (mja.com.au)
- It has been theorized that the fluoride in dental products may cause accidental poisoning, if ingested in large quantities. (ehow.com)
- Treatment for accidental carbon monoxide poisoning costs the US healthcare system some $1.3 billion every year ( e3 ). (aerzteblatt.de)
- They are easily accessible, thus they are a commonly associated with suicides and accidental poisoning. (medindia.net)
- In case of accidental ingestion, do not induce vomiting. (ewg.org)
- Accidental poisoning in children with special reference to kerosene poisoning. (cdc.gov)
- Most cases of poisoning are accidental. (wikipedia.org)
- Can we improve prognostic indications in acetaminophen-induced hepatic failure? (thepoisonreview.com)
- The standard tool used in evaluating acetaminophen-poisoned patients for possible orthotopic liver transplantation (OLT) is the King's College Criteria (KCC). (thepoisonreview.com)
- 14 years old) admitted to hospital and discharged with a diagnosis of acetaminophen-induced liver failure. (thepoisonreview.com)
- Acetylcysteine is used for acetaminophen poisoning for up to 72 hours after ingestion. (wikidoc.org)
- Clupeotoxin poisoning occurs in humans who eat fish contaminated with the toxin. (webmd.com)
- Ciguatera is a type of food poisoning caused due to the consumption of fish infected with a marine toxin called Ciguatera toxin. (medindia.net)
- This oily, sticky toxin occurs in many plants, including cashews (left) and poison ivy. (amnh.org)
- Atropine is NOT indicated in cases of poisoning by ibotenic acid or muscimol but is frequently cited as a treatment for A. muscaria poisonings in the medical literature, where the toxin is erroneously listed as muscarine! (namyco.org)
- If you or someone you know has ingested a fish that you suspect might be contaminated with ciguatera toxin, and you or they have signs or symptoms, such as nausea, vomiting, pain, trouble breathing, seizure, confusion, or abnormal skin color, call either an ambulance or the National Poison Control Center (1-800-222-1222) for guidance. (rxlist.com)
- Ipecac was formerly used to induce vomiting in poisoned patients where there was a chance to get the toxin out of the body. (rxlist.com)
- This poison, a toxin, does not go away when the fish is cooked. (aafp.org)
- The symptoms of scombroid poisoning last six to eight hours after you eat the toxin. (aafp.org)
- To avoid ciguatera poisoning, don't eat the fish that often carry the ciguatera toxin. (aafp.org)
- That's the number of humans who could-theoretically-succumb to the poison secreted by all of these frogs. (amnh.org)
- Arsenic poisoning in humans most often results from the ingestion or inhalation of insecticides containing arsenious oxide, copper acetoarsenite, or calcium or lead arsenate. (britannica.com)
- Dogs are generally more susceptible to chocolate poisoning than cats, no doubt because they are more likely to consume large quantities of chocolate, whereas cats are generally more selective eaters as well as being unable to taste sweetness so chocolate doesn't hold the same appeal as it does with dogs and humans. (cat-world.com.au)
- Many poisons, however, are substances meant for humans to eat, including foods and medicines. (emedicinehealth.com)
Self poisoning with p1
- If you or someone you know has swallowed or breathed in a poison, and you or they have serious signs or symptoms (nausea, vomiting, pain, trouble breathing, seizure, confusion, or abnormal skin color), you must either call an ambulance for transport to a hospital emergency department or call a poison control center for guidance. (emedicinehealth.com)
- Definitive diagnosis of arsenic poisoning is based on the finding of arsenic in the urine and in hair or nails. (britannica.com)
- The purpose of the study is to establish drug-induced liver injury databases in China, make criteria for Chinese drug-induced liver injury patients and evaluate the application of certain circulating miRNA in diagnosis or treatment of drug-induced liver injury. (clinicaltrials.gov)
- Otherwise,collect blood sample or other sample of the patients and study certain miRNA in diagnosis or treatment of drug-induced liver injury. (clinicaltrials.gov)
- Method for Inducing Protection in Animal Against Cyanide Poisoning Using 8-Aminoquinolines. (dtic.mil)
- This invention relates to novel means for inducing the production of blood methemoglobin in animals, at sufficient levels to afford post-or pretreatment of said animals against poisoning resulting from exposure to toxic levels of cyanide. (dtic.mil)
- The present invention avoids many problems associated with previously known treatments by orally administering a compound to induce constant, ongoing levels of methemoglobin sufficient to provide protection to animals, against exposure to toxic levels of cyanide. (dtic.mil)
- cyanide poisoning. (fda.gov)
- Thiosulfate is synergistic with sodium nitrite, and the two drugs should be used together to treat cyanide poisoning whenever possible. (calpoison.org)
- Severe cases of ciguatera poisoning require hospitalization for intravenous fluids. (rxlist.com)
Symptoms of ciguatera3
Deaths from paracetamol1
- Objective To assess the long term effect of United Kingdom legislation introduced in September 1998 to restrict pack sizes of paracetamol on deaths from paracetamol poisoning and liver unit activity. (bmj.com)
- Trauma , bleeding, or swelling of the brain can affect blood delivery, various poisons can also directly injure the brain, and brain inflammation and infection can also alter mental status and lead to coma. (medicinenet.com)
- On 7 September, doctors announced that they had taken Navalny out of the induced coma and that his condition had improved. (wikipedia.org)
- The final result of arsenic poisoning is coma and death. (wikipedia.org)
- Drug-induced liver diseases are diseases of the liver that are caused by physician-prescribed medications, over-the-counter medications, vitamins, hormones, herbs, illicit ("recreational") drugs, and environmental toxins. (emedicinehealth.com)
- If you are positive that your dog ingested grapes or raisins within the last two hours, you will need to induce vomiting as soon as possible, before all the toxins in the fruit can be absorbed. (petmd.com)
- Americans who eat out at restaurants are twice as likely to get food poisoning, compared to those who eat food prepared at home, Counsel & Heal reported. (foxnews.com)
- In a new study from the Center for Science in the Public Interest (CSPI), researchers analyzed 10,408 food poisoning outbreaks based on data from the Centers for Disease Control and Prevention (CDC). (foxnews.com)
- CSPI researchers believe food poisoning numbers may actually be higher, as many cases go underreported. (foxnews.com)
- Ciguatera is a type of food poisoning . (rxlist.com)
- When mixed into grain or other food, rats will readily consume the poison and die. (ehow.com)
- The results show that the epinephrine-induced bradyarrhythmia threshold is reduced and the frequency of arrhythmic events is augmented in rats exposed to ethanol in the drinking fluid. (springer.com)
- Evis MJ, Kane KA, Moore MR, Parratt JR (1986) The effects of ethanol and lead, alone and in combination on the severity of arrhythmias induced by coronary artery occlusion, and, by noradrenaline, in anaesthetised rats. (springer.com)
- Morvay V, Ungvary G (1979) Effects of simultaneous alcohol and toluene poisoning on the cardiovascular system in rats. (springer.com)
- F ) Stiripentol protected rats against hydroxyproline-induced renal failure. (jci.org)
- Legalon® SIL will be administered to patients with amatoxin poisoning diagnosed by history, gastrointestinal symptoms, elevated liver enzymes, and/or diagnostic assay (should one become available). (clinicaltrials.gov)
- Patients with suspected amatoxin poisoning are reviewed for enrollment in the study by contacting the Legalon SIL study hotline (866) 520-4412. (clinicaltrials.gov)
- Patients with mild drug induced liver disease may have few or no symptoms or signs. (emedicinehealth.com)
- Increasingly, patients are spending billions on "health" products or relying on their healthcare providers to manage self-induced problems with prescription medications, procedures, and surgeries, rather than altering the behavior that caused the problem. (naturallysavvy.com)
- In patients with severe carbon monoxide poisoning, an ECG should be obtained and biomarkers for cardiac ischemia should be measured. (aerzteblatt.de)
- In 2015, 648 patients died as a result of CO poisoning (0.8 deaths/100 000 population) (eTable). (aerzteblatt.de)
- Carbon monoxide (CO) poisoning is the most common cause of poisoning-related death in the world. (archivestsc.com)
- The symptoms of carbon monoxide (CO) poisoning are nonspecific, ranging from dizziness and headache to unconsciousness and death. (aerzteblatt.de)
- The initiation of 100% oxygen breathing as early as possible is the most important treatment for carbon monoxide poisoning. (aerzteblatt.de)
- In the USA, 20 000 50 000 cases of carbon monoxide poisoning occur every year ( 2 ). (aerzteblatt.de)
- The Minnesota Poison Control System does not take calls related to animal poisonings. (mnpoison.org)
- After the incident, help document mushroom poisonings by submitting an online report or mail-in report to the NAMA Poison Case Registry. (namyco.org)
- It is possible your vet will not be familiar with this source of poisoning as this information is fairly new and candies have not usually been associated with poisonings in dogs if they did not contain chocolate as the major ingredient. (vetinfo.com)
- We have the ability to help every poisoned pet, with all types of poisonings, 24 hours a day. (petpoisonhelpline.com)
- Any hepatotoxic agent capable of inducing liver steatosis or fatty liver disease. (ebi.ac.uk)
- It is necessary for your dog to eat raw salmon to get salmon poisoning disease. (vetinfo.com)
- Oxidative stress plays important role in pathogenesis of lead-induced toxity and pathogenesis of coupled disease. (csn-deutschland.de)
- As a medical school professor and researcher, I also had the latest data on the declining health of our nation, confirming what I was indeed seeing in my practice: The #1 Killer of Americans is an epidemic of SELF-induced disease and disability. (naturallysavvy.com)
- Arsenic poisoning , harmful effects of various arsenic compounds on body tissues and functions. (britannica.com)
- describe the ways that arsenic induces illness. (cdc.gov)
- In addition, arsenic induced carcinogenesis may have different mechanisms in different tissues with contributions from all species present in that tissue [ROM (cdc.gov)
- The organs of the body that are usually affected by arsenic poisoning are the lungs, skin, kidneys, and liver. (wikipedia.org)
- The data strongly suggested that lead induced anemia was a biologically and clinically important consequence of lead absorption, even at low levels of exposure. (cdc.gov)
- Alcohol, fish, nuts, and nut oils should be avoided after exposure to ciguatera poisoning because they may trigger recurrent symptoms. (rxlist.com)
- DO NOT use it to treat or manage an actual poison exposure. (medlineplus.gov)
- If you or someone you are with has an exposure, call your local emergency number (such as 911), or your local poison center can be reached directly by calling the national toll-free Poison Help hotline (1-800-222-1222) from anywhere in the United States. (medlineplus.gov)
- If more than one person has the same signs and symptoms, and they have a common exposure source, such as contaminated food, water, or workplace environment, then poisoning would be suspected. (emedicinehealth.com)
- Microinjection of AIF into the cytoplasm of intact cells induces condensation of chromatin, dissipation of the mitochondrial transmembrane potential, and exposure of phosphatidylserine in the plasma membrane. (nih.gov)
- This study investigated the effects of atorvastatin (ATS) on the paraquat (PQ)-induced epithelial-mesenchymal transition (EMT) and the potential mechanism through hypoxia-inducible factor-1 alpha (HIF-1α). (ovid.com)
- The mechanism may involve the downregulation of the HIF-1α/β-catenin pathway and the inhibition of the PQ-induced EMT by ATS. (ovid.com)
- The mechanism of lead induced toxity is not fully understood. (csn-deutschland.de)
- Contributory factors in herb-induced fatal aconite poisoning. (biomedsearch.com)
- In the present review of 12 fatal cases that were published in the medical journals during 1992 and 2011, the available clinical data and forensic toxicological analyses indicated that poor post-harvest processing of aconite roots, use of greater than the recommended doses and inadequate boiling of processed aconite roots during decoction preparation were important contributory factors in herb-induced aconite poisoning. (biomedsearch.com)
- Poisoning may also result from prolonged treatment with such medications as Fowler's solution (potassium arsenate) and arsphenamine. (britannica.com)
- Treatment of toxicodendron dermatitis (poison ivy and poison oak). (medscape.com)
- What is the treatment for ciguatera poisoning? (rxlist.com)
- A doctor should be consulted in every case about treatment for ciguatera poisoning, including available medications. (rxlist.com)
- Therefore, we investigated the effects of ethanol treatment on epinephrine-induced arrhythmias. (springer.com)
- Yohimbine for treatment of amitraz poisoning in dogs. (petpoisonhelpline.com)
- 2011 Annual report of the American Association of Poison Control Centers' National Poison Data System (NPDS): 29th Annual Report. (medscape.com)
- Several advisory bodies such as the American Association of Poison Control Centers and the American Academy of Pediatrics have recommended that Ipecac NOT be used and that it should not even be kept in the household. (rxlist.com)
- All local poison control centers in the United States use this national number. (medlineplus.gov)
- The results of this study indicate that the in vivo response of R56865 against induced bufadienolide cardiac disturbance in sheep is not as evident as that observed with R56865 against similar cardiac disturbances in vitro. (up.ac.za)
- Neuronal participation in methylmercury-induced cardiac and renal overgrowth. (duke.edu)
- however, 6-OHDA did not influence later phases of renal enlargement nor did it alter the CH3-Hg-induced cardiac overgrowth. (duke.edu)
- Adams MA, Hirst M (1986) The influence of adrenal medullectomy on the development of ethanol-induced cardiac hypertrophy. (springer.com)
- Hirst M, King DC (1990) Suppression of ethanol-induced cardiac hypertrophy in the rat requires inhibition of both myocardial Β 1 and Β 2 adrenoceptors. (springer.com)
- A new study conducted by American researchers reveal that consumption of Indian spices will increase the risk of lead poisoning, especially among children. (medindia.net)
- Authorities in southwestern China have closed a factory after nearly 100 people -- most of them children -- tested positive for lead poisoning, state media said Monday. (medindia.net)
- We now provide evidence that 4-hydroxynonenal (HNE), an aldehydic product of membrane lipid peroxidation, is a key mediator of neuronal apoptosis induced by oxidative stress. (jneurosci.org)
- Oxidative insults (FeSO 4 and amyloid β-peptide) induced lipid peroxidation, cellular accumulation of HNE, and apoptosis. (jneurosci.org)
- Antioxidants that suppress lipid peroxidation protected against apoptosis induced by oxidative insults, but not that induced by HNE. (jneurosci.org)
- Reactive oxygen species (ROS) are generated in several metabolic pathways, a major source being mitochondrially derived superoxide anion radical, which gives rise to hydrogen peroxide, which is converted further to hydroxyl radical, which induces membrane lipid peroxidation ( Evans, 1993 ). (jneurosci.org)
- Of 14 distinctive types of mushroom poisoning found worldwide, so far about 10 distinctive patterns of reactions to mycotoxins have been observed in North America. (namyco.org)
- NAMA maintains a case registry where you may report instances of mushroom poisoning. (namyco.org)
- The most frequent form of mushroom poisoning is caused by a wide variety of gastrointestinal irritants. (namyco.org)
- The Anticancer Drug Action Lab is studying cellular responses to DNA damage induced by topoisomerase poisons. (mayo.edu)
- In particular, our research team is examining factors that potentially affect the ability of these drugs to inhibit topoisomerase I (drug uptake and posttranslational modifications of topoisomerase I). We are also studying cellular responses to drug-induced trapping of covalent topoisomerase I-DNA complexes. (mayo.edu)
- This unique reagent is being applied in preclinical and clinical studies to determine whether the stabilization of drug-induced covalent topoisomerase I-DNA complexes varies from tumor to tumor and whether this variation correlates with tumor sensitivity. (mayo.edu)
- Building on these results, we are also currently investigating the possible beneficial effects of combining ATR or Chk1 inhibitors with topoisomerase I poisons in preclinical cancer models. (mayo.edu)
- Do not induce vomiting or give syrup of Ipecac. (rxlist.com)
- Emesis can be induced by giving the cat a tablespoon of syrup of ipecac (less to small cats), OR a tablespoon of hydrogen peroxide. (maxshouse.com)
- Use syrup of ipecac only on advice of the poison control center or a physician. (montgomerycountymd.gov)
- HNE induced apoptosis in PC12 cells and primary rat hippocampal neurons. (jneurosci.org)
- Bcl-2 prevented apoptosis of PC12 cells induced by oxidative stress and HNE. (jneurosci.org)
- Glutathione, which binds HNE, protected neurons against apoptosis induced by oxidative stress and HNE. (jneurosci.org)
- Collectively, the data identify that HNE is a novel nonprotein mediator of oxidative stress-induced neuronal apoptosis and suggest that the antiapoptotic action of glutathione may involve detoxification of HNE. (jneurosci.org)
- may play roles in oxidative stress-induced apoptosis. (jneurosci.org)
- It is not known whether HNE induces apoptosis nor whether HNE is involved mechanistically in oxidative stress-induced apoptosis. (jneurosci.org)
- We now report that HNE is generated in response to apoptotic oxidative insults and can induce neuronal apoptosis at pathophysiologically relevant concentrations. (jneurosci.org)
- Molecular characterization of mitochondrial apoptosis-inducing factor. (nih.gov)
- Here we report the identification and cloning of an apoptosis-inducing factor, AIF, which is sufficient to induce apoptosis of isolated nuclei. (nih.gov)
- it is normally confined to mitochondria but translocates to the nucleus when apoptosis is induced. (nih.gov)
- Once you're sure the person's (or your own) condition is stable, call your local poison control center or poison help hotline for further instructions. (wikihow.com)
- If you live in the U.S., call the national Poison Control hotline at 1-800-222-1222. (wikihow.com)
- Once you get in touch with emergency medical personnel or a poison help hotline, tell them as much as you can about both the poison and the poisoning victim. (wikihow.com)
- Dark chocolate, baking chocolate, and dry cocoa powder are the biggest risks and if your cat has consumed any of these, call your poisons hotline or speak to your veterinarian. (cat-world.com.au)
- Your local poison control center can be reached directly by calling the national toll-free Poison Help hotline (1-800-222-1222) from anywhere in the United States. (medlineplus.gov)
- This hotline number will let you talk to experts in poisoning. (medlineplus.gov)
- What is the role of endothelial cells in cocaine-induced vasoconstriction? (medscape.com)
- In her new autobiography, the singer , 33, claims the actor had a cocaine-induced heart attack at Glastonbury when she was 13. (thesun.co.uk)
- He texted me, 'Err cocaine induced heart attack at Glastonbury. (thesun.co.uk)
Nearest poison contro2
- ATS alleviated PQ poisoning-induced lung injury and pulmonary fibrosis in vivo. (ovid.com)
- In conclusion, ATS can attenuate PQ-induced pulmonary fibrosis. (ovid.com)
- ATS may be considered as a therapeutic agent for PQ poisoning-induced pulmonary fibrosis. (ovid.com)
- 1991. Pulmonary radiology changes in kerosene poisoning in the Asir region of Saudi Arabia. (cdc.gov)