A metallic element, atomic number 49, atomic weight 114.82, symbol In. It is named from its blue line in the spectrum. (From Dorland, 28th ed)
Unstable isotopes of indium that decay or disintegrate emitting radiation. In atoms with atomic weights 106-112, 113m, 114, and 116-124 are radioactive indium isotopes.
Isotopes that exhibit radioactivity and undergo radioactive decay. (From Grant & Hackh's Chemical Dictionary, 5th ed & McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
Inorganic compounds that contain tin as an integral part of the molecule.
An antiseptic with mild fungistatic, bacteriostatic, anthelmintic, and amebicidal action. It is also used as a reagent and metal chelator, as a carrier for radio-indium for diagnostic purposes, and its halogenated derivatives are used in addition as topical anti-infective agents and oral antiamebics.
Unstable isotopes of zinc that decay or disintegrate emitting radiation. Zn atoms with atomic weights 60-63, 65, 69, 71, and 72 are radioactive zinc isotopes.
Inorganic or organic compounds derived from phosphine (PH3) by the replacement of H atoms. (From Grant & Hackh's Chemical Dictionary, 5th ed)
Method for assessing flow through a system by injection of a known quantity of radionuclide into the system and monitoring its concentration over time at a specific point in the system. (From Dorland, 28th ed)
A rare, metallic element designated by the symbol, Ga, atomic number 31, and atomic weight 69.72.
The 8-hydroxy derivatives inhibit various enzymes and their halogenated derivatives, though neurotoxic, are used as topical anti-infective agents, among other uses.
Unstable isotopes of strontium that decay or disintegrate spontaneously emitting radiation. Sr 80-83, 85, and 89-95 are radioactive strontium isotopes.
Unstable isotopes of iodine that decay or disintegrate emitting radiation. I atoms with atomic weights 117-139, except I 127, are radioactive iodine isotopes.
Unstable isotopes of krypton that decay or disintegrate emitting radiation. Kr atoms with atomic weights 74-77, 79, 81, 85, and 87-94 are radioactive krypton isotopes.
A seven-membered aromatic ring compound. It is structurally related to a number of naturally occurring antifungal compounds (ANTIFUNGAL AGENTS).
Unstable isotopes of yttrium that decay or disintegrate emitting radiation. Y atoms with atomic weights 82-88 and 90-96 are radioactive yttrium isotopes.
Unstable isotopes of sodium that decay or disintegrate emitting radiation. Na atoms with atomic weights 20-22 and 24-26 are radioactive sodium isotopes.
The first artificially produced element and a radioactive fission product of URANIUM. Technetium has the atomic symbol Tc, atomic number 43, and atomic weight 98.91. All technetium isotopes are radioactive. Technetium 99m (m=metastable) which is the decay product of Molybdenum 99, has a half-life of about 6 hours and is used diagnostically as a radioactive imaging agent. Technetium 99 which is a decay product of technetium 99m, has a half-life of 210,000 years.
The spontaneous transformation of a nuclide into one or more different nuclides, accompanied by either the emission of particles from the nucleus, nuclear capture or ejection of orbital electrons, or fission. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
A class of compounds of the type R-M, where a C atom is joined directly to any other element except H, C, N, O, F, Cl, Br, I, or At. (Grant & Hackh's Chemical Dictionary, 5th ed)
Unstable isotopes of barium that decay or disintegrate emitting radiation. Ba atoms with atomic weights 126-129, 131, 133, and 139-143 are radioactive barium isotopes.
Scandium. An element of the rare earth family of metals. It has the atomic symbol Sc, atomic number 21, and atomic weight 45.
The production of an image obtained by cameras that detect the radioactive emissions of an injected radionuclide as it has distributed differentially throughout tissues in the body. The image obtained from a moving detector is called a scan, while the image obtained from a stationary camera device is called a scintiphotograph.
Unstable isotopes of tin that decay or disintegrate emitting radiation. Sn atoms with atomic weights 108-111, 113, 120-121, 123 and 125-128 are tin radioisotopes.
An iron chelating agent with properties like EDETIC ACID. DTPA has also been used as a chelator for other metals, such as plutonium.
Unstable isotopes of carbon that decay or disintegrate emitting radiation. C atoms with atomic weights 10, 11, and 14-16 are radioactive carbon isotopes.
Unstable isotopes of iron that decay or disintegrate emitting radiation. Fe atoms with atomic weights 52, 53, 55, and 59-61 are radioactive iron isotopes.
Techniques for labeling a substance with a stable or radioactive isotope. It is not used for articles involving labeled substances unless the methods of labeling are substantively discussed. Tracers that may be labeled include chemical substances, cells, or microorganisms.
Unstable isotopes of copper that decay or disintegrate emitting radiation. Cu atoms with atomic weights 58-62, 64, and 66-68 are radioactive copper isotopes.
Unstable isotopes of phosphorus that decay or disintegrate emitting radiation. P atoms with atomic weights 28-34 except 31 are radioactive phosphorus isotopes.
Apparatus and instruments that generate and operate with ELECTRICITY, and their electrical components.
High energy POSITRONS or ELECTRONS ejected from a disintegrating atomic nucleus.
A refined petroleum fraction used as a fuel as well as a solvent.
Materials that have a limited and usually variable electrical conductivity. They are particularly useful for the production of solid-state electronic devices.
Unstable isotopes of mercury that decay or disintegrate emitting radiation. Hg atoms with atomic weights 185-195, 197, 203, 205, and 206 are radioactive mercury isotopes.
A gamma-emitting radionuclide imaging agent used for the diagnosis of diseases in many tissues, particularly in the gastrointestinal system, liver, and spleen.
Stable cesium atoms that have the same atomic number as the element cesium, but differ in atomic weight. Cs-133 is a naturally occurring isotope.
Unstable isotopes of cerium that decay or disintegrate emitting radiation. Ce atoms with atomic weights 132-135, 137, 139, and 141-148 are radioactive cerium isotopes.
Stable cobalt atoms that have the same atomic number as the element cobalt, but differ in atomic weight. Co-59 is a stable cobalt isotope.
Hafnium. A metal element of atomic number 72 and atomic weight 178.49, symbol Hf. (From Dorland, 28th ed)
Unstable isotopes of gold that decay or disintegrate emitting radiation. Au 185-196, 198-201, and 203 are radioactive gold isotopes.
Unstable isotopes of lead that decay or disintegrate emitting radiation. Pb atoms with atomic weights 194-203, 205, and 209-214 are radioactive lead isotopes.
Any diagnostic evaluation using radioactive (unstable) isotopes. This diagnosis includes many nuclear medicine procedures as well as radioimmunoassay tests.
Stable zinc atoms that have the same atomic number as the element zinc, but differ in atomic weight. Zn-66-68, and 70 are stable zinc isotopes.
Unstable isotopes of sulfur that decay or disintegrate spontaneously emitting radiation. S 29-31, 35, 37, and 38 are radioactive sulfur isotopes.
The administration of therapeutic agents drop by drop, as eye drops, ear drops, or nose drops. It is also administered into a body space or cavity through a catheter. It differs from THERAPEUTIC IRRIGATION in that the irrigate is removed within minutes, but the instillate is left in place.
The morning glory family of flowering plants, of the order Solanales, which includes about 50 genera and at least 1,400 species. Leaves are alternate and flowers are funnel-shaped. Most are twining and erect herbs, with a few woody vines, trees, and shrubs.
Unstable isotopes of cadmium that decay or disintegrate emitting radiation. Cd atoms with atomic weights 103-105, 107, 109, 115, and 117-119 are radioactive cadmium isotopes.
Astatine. A radioactive halogen with the atomic symbol At, atomic number 85, and atomic weight 210. Its isotopes range in mass number from 200 to 219 and all have an extremely short half-life. Astatine may be of use in the treatment of hyperthyroidism.
Radiotherapy where cytotoxic radionuclides are linked to antibodies in order to deliver toxins directly to tumor targets. Therapy with targeted radiation rather than antibody-targeted toxins (IMMUNOTOXINS) has the advantage that adjacent tumor cells, which lack the appropriate antigenic determinants, can be destroyed by radiation cross-fire. Radioimmunotherapy is sometimes called targeted radiotherapy, but this latter term can also refer to radionuclides linked to non-immune molecules (see RADIOTHERAPY).
Determination of the quantity of a material present in a mixture by measurement of its effect on the electrical conductivity of the mixture. (Webster, 3d ed)
Lutetium. An element of the rare earth family of metals. It has the atomic symbol Lu, atomic number 71, and atomic weight 175.
An indole-dione that is obtained by oxidation of indigo blue. It is a MONOAMINE OXIDASE INHIBITOR and high levels have been found in urine of PARKINSONISM patients.
Flammable, amorphous, vegetable products of secretion or disintegration, usually formed in special cavities of plants. They are generally insoluble in water and soluble in alcohol, carbon tetrachloride, ether, or volatile oils. They are fusible and have a conchoidal fracture. They are the oxidation or polymerization products of the terpenes, and are mixtures of aromatic acids and esters. Most are soft and sticky, but harden after exposure to cold. (From Grant & Hackh's Chemical Dictionary, 5th ed & Dorland, 28th ed)
Rhenium. A metal, atomic number 75, atomic weight 186.2, symbol Re. (Dorland, 28th ed)
Accumulation of a drug or chemical substance in various organs (including those not relevant to its pharmacologic or therapeutic action). This distribution depends on the blood flow or perfusion rate of the organ, the ability of the drug to penetrate organ membranes, tissue specificity, protein binding. The distribution is usually expressed as tissue to plasma ratios.
Samarium. An element of the rare earth family of metals. It has the atomic symbol Sm, atomic number 62, and atomic weight 150.36. The oxide is used in the control rods of some nuclear reactors.
Nitric acid (HNO3). A colorless liquid that is used in the manufacture of inorganic and organic nitrates and nitro compounds for fertilizers, dye intermediates, explosives, and many different organic chemicals. Continued exposure to vapor may cause chronic bronchitis; chemical pneumonitis may occur. (From Merck Index, 11th ed)
Compounds that are used in medicine as sources of radiation for radiotherapy and for diagnostic purposes. They have numerous uses in research and industry. (Martindale, The Extra Pharmacopoeia, 30th ed, p1161)
A PULMONARY ALVEOLI-filling disease, characterized by dense phospholipoproteinaceous deposits in the alveoli, cough, and DYSPNEA. This disease is often related to, congenital or acquired, impaired processing of PULMONARY SURFACTANTS by alveolar macrophages, a process dependent on GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR.
Pollutants, present in soil, which exhibit radioactivity.

Similarities and differences in 111In- and 90Y-labeled 1B4M-DTPA antiTac monoclonal antibody distribution. (1/942)

Monoclonal antibodies (MoAb) labeled with 90Y are being used for radioimmunotherapy. Because 90Y is a beta emitter, quantitative information from imaging is suboptimal. With the concept of a "matched pair" of isotopes, 111In is used as a surrogate markerfor90Y. We evaluated the differences in biodistribution between 111In- and 90Y-labeled murine antiTac MoAb directed against the IL-2Ralpha receptor. METHODS: The antiTac was conjugated to the 2-(4-isothiocyanatobenzyl)-6-methyl-diethylenetriamine pentaacetic acid (1B4M-DTPA, also known as MX-DTPA). Nine patients with adult T-cell leukemia were treated. Patients received approximately 185 MBq (5 mCi) 111In-labeled antiTac for imaging and 185-555 MBq (5-15 mCi) 90Y-labeled antiTac for therapy. The immunoreactivity of 111In-labeled antiTac was 90%+/-6%, whereas for 90Y-labeled antiTac, it was 74%+/-12%. RESULTS: The differences in blood and plasma kinetics of the two isotopes were small. The area undemeath the blood radioactivity curve was 1.91 percentage+/-0.58 percentage injected dose (%ID) x h/mL for 111In and 1.86%+/-0.64 %ID x h/mL for 90Y. Urinary excretion of 90Y was significantly greater than that of 111In in the first 24 h (P = 0.001), but later, the excretion of 111In was significantly greater (P = 0.001 to P = 0.04). Core biopsies of bone marrow showed a mean of 0.0029+/-0.0012 %ID/g for 111In, whereas the 90Y concentration was 0.0049+/-0.0021 %ID/g. Analyses of activity bound to circulating cells showed concentrations of 500-30,000 molecules of antiTac per cell. When cell-bound activity was corrected for immunoreactive fraction, the ratio of 111In to 90Y in circulating cells was 1.11+/-0.17. Three biopsies of tumor-involved skin showed ratios of 111In to 90Y of 0.7, 0.9 and 1.1. CONCLUSION: This study shows that differences typically ranging from 10% to 15% exist in the biodistribution between 111In- and 90Y-labeled antiTac. Thus, it appears that 111In can be used as a surrogate marker for 90Y when labeling antiTac with the 1 B4M chelate, although underestimates of the bone marrow radiation dose should be anticipated.  (+info)

Segmental colonic transit after oral 67Ga-citrate in healthy subjects and those with chronic idiopathic constipation. (2/942)

Measurement of segmental colonic transit is important in the assessment of patients with severe constipation. 111In-diethylenetriamine pentaacetic acid (DTPA) has been established as the tracer of choice for these studies, but it is expensive and not readily available. 67Ga-citrate is an inexpensive tracer and when given orally is not absorbed from the bowel. It was compared with 111In-DTPA in colonic transit studies in nonconstipated control subjects and then in patients with idiopathic constipation. METHODS: Studies were performed after oral administration of 3 MBq (81 microCi) 67Ga-citrate or 4 MBq (108 microCi) 111In-DTPA in solution. Serial abdominal images were performed up to 96 h postinjection, and computer data were generated from geometric mean images of segmental retention of tracer, mean activity profiles and a colonic tracer half-clearance time. RESULTS: There were no differences in segmental retention of either tracer or in mean activity profiles between control subjects and constipated patients. Results in constipated subjects were significantly different from those in controls. The mean half-clearance times of tracer for control subjects were 28.8 h for 67Ga-citrate and 29.9 h for 111In-DTPA in control subjects and 75.0 h for 67Ga-citrate and 70.8 h for 111In-DTPA in constipated patients. CONCLUSION: Oral 67Ga-citrate can be used as a safe alternative to 111In-DTPA for accurate measurement of segmental colonic transit.  (+info)

Using vascular structure for CT-SPECT registration in the pelvis. (3/942)

The authors outline a method for three-dimensional registration of pelvic CT and 111In-labeled monoclonal antibody capromab pendetide (111In MoAb 7E11.C5) images using 99mTc-labeled red blood cell SPECT data. METHODS: This method of CT-SPECT registration relies on the identification of major blood vessels in the CT and 99mTc SPECT images. The vessels are segmented from the image datasets by outlining them on transverse planar slices using a mouse-based drawing tool. Stacking the transverse outlines provides a three-dimensional representation of the vascular structures. Registration is performed by matching the surfaces of the segmented volumes. Dual isotope acquisition of 111In and 99mTc activities provides precise SPECT-SPECT registration so that registration in three dimensions of the 111In MoAb and CT images is achieved by applying the same transformation obtained from the 99mTc SPECT-CT registration. RESULTS: This method provided accurate registration of pelvic structures and significantly improved interpretation of 111In MoAb 7E11.C5 exams. Furthermore, sites of involvement by prostate cancer suggested by the 111In MoAb examination could be interpreted with the bony and soft tissue (nodal) anatomy seen on CT. CONCLUSION: This method is a general clinical tool for the registration of pelvic CT and SPECT imaging data. There are immediate applications in conformal radiation therapy treatment planning for certain prostate cancer patients.  (+info)

In vivo localization of [(111)In]-DTPA-D-Phe1-octreotide to human ovarian tumor xenografts induced to express the somatostatin receptor subtype 2 using an adenoviral vector. (4/942)

Adenoviral vectors, encoding genes for cell surface antigens or receptors, have been used to induce their high level expression on tumor cells in vitro and in vivo. These induced antigens and receptors can then be targeted with radiolabeled antibodies or peptides for potential radiotherapeutic applications. The purpose of this study was to determine a dosing schema of an adenoviral vector encoding the human somatostatin receptor subtype 2 (AdCMVhSSTr2) for achieving the highest tumor localization of [(111)In]-DTPA-D-Phe1-octreotide, which binds to this receptor, in a human ovarian cancer model as a prelude to future therapy studies. AdCMVhSSTr2 was produced and used to induce hSSTr2 on A427 human nonsmall cell lung cancer cells and on SKOV3.ipl human ovarian cancer cells in vitro, as demonstrated by competitive binding assays using [125I]-Tyr1-somatostatin and [(111)In]-DTPA-D-Phe1-octreotide. Mice bearing i.p. SKOV3.ip1 tumors administered 1 x 10(9) plaque-forming units of AdCMVhSSTr2 i.p. 5 days after tumor cell inoculation, followed by an i.p. injection of [(111)In]-DTPA-D-Phe1-octreotide 2 days later, showed a range of 15.3-60.4% median injected dose/gram (ID/g) in tumor at 4 h after injection compared with 3.5% ID/g when [125I]-Tyr1-somatostatin was administered and 0.3% ID/g when the negative control peptide [125I]-mIP-bombesin was administered. Mice administered a control adenoviral vector encoding the gastrin-releasing peptide receptor did not have tumor localization of [(111)In]-DTPA-D-Phe1-octreotide (<1.6% ID/g), demonstrating specificity of [(111)In]-DTPA-D-Phe1-octreotide for the AdCMVhSSTr2 induced tumor cells. In another set of experiments, the tumor localization of [(111)In]-DTPA-D-Phe1-octreotide was not different 1, 2, or 4 days after AdCMVhSSTr2 injection (31.8, 37.7, and 40.7% ID/g, respectively; P = 0.88), indicating that multiple injections of radiolabeled peptide can be administered with equivalent uptake over a 4-day period. [(111)In]-DTPA-D-Phe1-octreotide tumor localization in animals administered AdCMVhSSTr2 on consecutive days or 2 days apart was 22.4% ID/g and 53.2% ID/g, respectively (P = 0.009) when [(111)In]-DTPA-D-Phe1-octreotide was given 1 day after the second AdCMVhSSTr2 injection. There was no difference in [(111)In]-DTPA-D-Phe1-octreotide localization after a single AdCMVhSSTr2 injection (40.7% ID/g) or two injections of AdCMVhSSTr2 given 1 (45.9% ID/g) or 2 (53.2% ID/g) days apart, where [(111)In]-DTPA-D-Phe1-octreotide was given in each case 4 days after the first AdCMVhSSTr2 injection (P = 0.65). Therefore, two AdCMVhSSTr2 injections did not increase [(111)In]-DTPA-D-Phe1-octreotide tumor localization compared with one injection, which eliminates concerns about an immune response to a second dose of AdCMVhSSTr2. This will be the basis for a therapeutic protocol with multiple administrations of an octreotide analogue labeled with a therapeutic radioisotope.  (+info)

Pharmacokinetics and disposition characteristics of recombinant decorin after intravenous injection into mice. (5/942)

The pharmacokinetics and disposition characteristics of recombinant decorin after intravenous administration were investigated in mice. Following bolus injection of 111In-labeled decorin at doses of 0.02 and 0.1 mg/kg, radioactivity rapidly disappeared from the circulation and approximately 70% of the dose accumulated in liver within 10 min. 111In-labeled decorin was preferentially localized in hepatic nonparenchymal cells. At a higher dose of 1 mg/kg, clearance from the circulation and hepatic uptake of [111In]decorin were slower than at lower doses. Both the accumulation in other tissues and urinary excretion of [111In]decorin were 5% or less. Pharmacokinetic analysis demonstrated that hepatic uptake clearance was large and accounted almost completely for total body clearance; in addition the clearance values decreased as the dose increased, suggesting that the hepatic uptake of decorin is mediated by a specific mechanism which becomes saturated at higher doses. In competitive inhibition experiments, hepatic uptake of 111In-labeled decorin was partially inhibited (about 20-30%) by several sulfated glycans such as glycosaminoglycans and dextran sulfate and by mannosylated bovine serum albumin (BSA), mannan and mannose to a lesser extent (about 10%). On the other hand, polyinosinic acid, polycytidylic acid and succinylated BSA were ineffective, suggesting that the scavenger receptor for polyanions in the liver is not involved in the hepatic uptake of decorin. A basic protein, protamine, and a ligand of the apoE receptor, lactoferrin, also had no effect. Taken together, the present results have demonstrated that recombinant decorin is rapidly eliminated from the blood circulation through extensive uptake by the liver, primarily by the nonparenchymal cells, following systemic administration. The sugar structure and mannose residue in decorin have also been suggested to play an important role in the hepatic uptake of decorin. These findings provide useful information for the development of decorin as a therapeutic agent.  (+info)

Biodistribution, radiation dosimetry and pharmacokinetics of 111In-antimyosin in idiopathic inflammatory myopathies. (6/942)

In view of the established role of 111In-antimyosin in the detection of heart muscle pathology, radiation dose estimates were made for this substance. Biodistribution and biokinetic data were obtained from our studies, which failed to show abnormal uptake of 111In-antimyosin in localized sites of skeletal muscle involvement in patients with idiopathic inflammatory myopathies. METHODS: After intravenous administration of 74 MBq (2 mCi) 111In-antimyosin, gamma camera scintigraphy was performed in 12 adult patients with inflammatory muscle disease and in 2 control patients. Six whole-body scans were performed over 72 h, and uptake of 111In-antimyosin in organs was quantified using an attenuation-corrected conjugate counting method. Residence times in source organs were used with MIRDOSE software to obtain radiation dose estimates. Pharmacokinetic parameters were derived from serial whole-blood and plasma 111In concentrations. RESULTS: The tracer cleared slowly from the circulation, and highest organ uptakes were found in the marrow and liver; kidneys showed the highest concentrations. Uptake was also evident in spleen, the facial image and male genitalia. CONCLUSION: For a typical administered activity of 74 MBq 111In-antimyosin, the kidneys receive the highest dose (58 mSv), and the effective dose is 11 mSv. Radioactivity was cleared from plasma at an average rate of 136 mL/h, and the mean steady-state distribution was approximately 5 L plasma.  (+info)

The relationship of glycosylation and isoelectric point with tumor accumulation of avidin. (7/942)

Radiolabeled avidin markedly accumulated in intraperitoneal tumors and was cleared rapidly from circulation when given intraperitoneally. This study investigated the mechanisms of the tumor localization of avidin. METHODS: Avidin was deglycosylated through endoglycosydase-H digestion and/or neutralized by acetylation of its lysine amino acids with acetic acid N-hydroxysuccinimide ester. Avidin and modified avidins were analyzed using sodium dodecylsulfate-polyacrylamide gel electrophoresis (SDS/PAGE) and isoelectric focusing. A tumor model was established by intraperitoneal injection of human colon cancer cells, LS180, in nude mice. Avidin and modified avidins were labeled with 111In using diethyleneamine pentaacetic acid-biotin and were administered intraperitoneally into the tumor-bearing mice. The biodistribution of radioactivity was examined 2 and 24 h postinjection. RESULTS: Deglycosylated avidins revealed a major band of smaller molecules on SDS/PAGE. The isoelectric point of neutralized avidins was reduced to less than 5, whereas that of unneutralized avidins was more than 9.5. Biodistribution study demonstrated that liver uptake was decreased by deglycosylation and kidney accumulation was decreased by neutralization, respectively. The blood clearance was remarkably slowed by combined modification of deglycosylation and neutralization. The tumor uptake of radioactivity was reduced by either deglycosylation or neutralization and was further decreased with combined modification. CONCLUSION: Both high glycosylation and positive charge of avidin contributed to its accumulation in tumor. This study may facilitate development of a new vehicle for the delivery of therapeutic agents to intraperitoneal tumors.  (+info)

Pretargeting of bacterial endocarditis in rats with streptavidin and 111In-labeled biotin. (8/942)

A radioimaging approach for the detection of endocarditis has been investigated using two-step pretargeting with streptavidin and radiolabeled biotin. METHODS: Hemodynamic alterations within the rat heart were induced by placing an in-dwelling catheter into the left ventricle through the aortic valves. The animals were subsequently infected with Staphylococcus aureus through a tail vein. After an incubation period, rats were first injected with streptavidin and, 2 h later, with 111In-labeled ethylene-diaminetetraacetic acid-biotin. Whole-body gamma camera images were taken 4-5 h postinjection of the radiolabeled biotin. Control animals consisted of catheterized but uninfected, infected but uncatheterized and normal untreated rats. As a further control, the labeled biotin was administered to a study animal without the preadministration of streptavidin. RESULTS: Histology showed typical endocarditic changes in the hearts of study animals with massive deposition of gram-positive cocci. Catheterized but uninfected animals showed alterations corresponding to nonbacterial thrombotic endocarditis. Macroautoradiography showed accumulation of radiolabel in the endocarditic vegetations of study animals. Whole-body gamma camera images showed important cardiac uptake in 7 of 8 catheterized and infected animals and in 3 of 6 catheterized but uninfected animals. Normal rats and those infected but not catheterized showed negative results by histology, autoradiography and imaging. The percent uptake of the injected dose in the heart was 0.20 (SD = 0.13) in catheterized and infected animals, 0.12 (SD = 0.10) in catheterized but uninfected animals, 0.10 (SD = 0.04) in infected but uncatheterized animals and 0.04 (SD = 0.01) in normal control animals. CONCLUSION: The two-step pretargeting approach using streptavidin and 111In-labeled biotin was used successfully to detect S. aureus-induced bacterial endocarditis in rats.  (+info)

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UNLABELLED The present study evaluated the role of SPECT/CT as an adjunct to (67)Ga (GS) or (111)In-labeled white blood cell (WBC) scintigraphy for diagnosis or localization of infection. METHODS Eighty-two patients (56 male and 26 female; mean age, 62 y) assessed for known or suspected infectious processes underwent 88 SPECT/CT studies. Forty-seven patients underwent GS SPECT/CT (13 with fever of unknown origin, 21 with suspected osteomyelitis, and 13 with suspected soft-tissue infection), and 35 patients underwent WBC SPECT/CT (24 with suspected vascular graft infection, and 11 with suspected osteomyelitis). Ninety-eight suggestive sites were identified (52 on GS and 46 on WBC). Additional information provided by SPECT/CT for diagnosis or localization of infection, as compared with planar and SPECT scintigraphy, was recorded. The SPECT/CT contribution was analyzed on a patient and site basis and was compared for the 2 tracers and clinical indications. RESULTS SPECT/CT provided additional
The investigators hypothesize that the new imaging method Gallium-68-DOTATATE has a higher diagnostic value in the detection of neuroendocrine tumors than the established imaging method Indium-111-Octreoscan. Therefore, the investigators will perform both imaging procedures in patients with suspected or confirmed neuroendocrine tumors. Subsequently, the investigators will compare the diagnostic performance of both methods ...
Purpose: It is often assumed that animal biodistributions of novel proteins are not dependent upon the radiolabel used in their determination. In units of percent injected dose per gram of tissue (%ID/g), organ uptake results (u) may be obtained using either iodine or metal as radioactive labels. Iodination is preferred as it is a one-step process whereas metal labeling requires two chemical procedures and therefore more protein material. It is important to test whether the radioactive tag leads to variation in the uptake value. Methods: Uptakes of 3antibodies to Carcinoembryonic Antigen (CEA) were evaluated in a nude mouse model bearing 150 to 300 mg LS174T human colon cancer xenografts. Antibodies included diabody (56 kDa), minibody (80kDa) and intact M5A (150 kDa) anti-CEA cognates. Both radioiodine and indium-111 labels were used with uptakes evaluated at 7 time(t) points out to 96 h. Ratios (R) of u(iodine-label)/u(indium-label) were determined for liver, spleen, kidneys, lung and tumor. ...
Linda J. Addonizio, Robert E. Michler, Charles Marboe, Peter E. Esser, Lynne L. Johnson, David W. Seldin, Welton M. Gersony, Philip O. Alderson, Eric A. Rose, Paul J. Cannon ...
Abarelix clearance is increased when carefully taken along with Capromab pendetide. Diet, lifestyle advice columnist and poses difficult to find. Read More ...
Affibody molecules are a novel class of targeting proteins, demonstrating promising results in the molecular imaging of tumor markers. The aim of this study was to investigate the cellular processing of Affibody molecules bound to human epidermal growth-factor-receptor type 2 (HER2). Cellular processing of the synthetic Affibody molecule, DOTA-Z(HER2:342-pep2) (K(D) = 65 (p)M) labeled with indium-111, was studied both during continuous and interrupted incubation with HER2-expressing cell lines (SKOV-3, SKBR-3, and BT474). The internalized and membrane bound fractions of Affibody molecule were discriminated by treatment with 4 M of urea solution in 0.2 M of glycine buffer (pH 2.0). Incubation media collected after an interrupted incubation was analyzed for the presence of radiocatabolites. Continuous incubation of tumor cells with (111)In-DOTA-Z(HER2:342-pep2) led to the saturation of HER2 and slow internalization. Sixty (60)- to 80% of the radioactivity remained cell associated 24 hours after ...
Various techniques for detection of blood platelets in tissue section were evaluated in an incremental air embolism model of ischemia in order to further investigate the accumulation of platelets in brains subjected to cell-damaging ischemia. The experimental animals were dogs anesthetized with alpha-chloralose. A new autoradiographic technique was devised that allows precise localization of 111Indium-labeled platelets in brain sections. The technique is described in detail along with some effects of the label on platelet function and behavior. The technique can be performed in conjunction with 14C-iodoantipyrine autoradiographic measurement of blood flow without causing mutual interference or other forms of interaction. This permits the simultaneous investigation of local blood flow and deposition of platelets. ...
Indium In 111 ProstaScint (Capromab Pendetide) is indicated as a diagnostic imaging agent in newly-diagnosed patients with biopsy-proven prostate cancer, thought to be clinically-localized after standard diagnostic evaluation (eg chest x-ray, bone scan, CT scan, or MRI), who are at high-risk for pelvic lymph node metastases. It is not indicated for patients who are not at high risk.. Indium In 111 ProstaScint is also indicated as a diagnostic imaging agent in post-prostatectomy patients with a rising PSA and a negative or equivocal standard metastatic evaluation in whom there is a high clinical suspicion of occult metastatic disease. The imaging performance of Indium In 111 ProstaScint following radiation therapy has not been studied.. The information provided by Indium In 111 ProstaScint imaging should be considered in conjunction with other diagnostic information. Scans that are positive for metastatic disease should be confirmed histologically in patients who are otherwise candidates for ...
Most of the time you do not need special preparation. You will need to sign a consent form.. For the test, you will need to wear a hospital gown or loose clothing. You will need to take off all jewelry.. Tell your provider if you are pregnant. This procedure is NOT recommended if you are pregnant or trying to become pregnant. Women of childbearing age (before menopause) should use some form of birth control during the course of this procedure.. Tell your provider if you have or had any of the following medical conditions, procedures, or treatments, as they can interfere with test results:. ...
1. The rate of clearance from blood of 111In-labelled heat damaged autologous erythrocytes (HD-RBC) has been compared with that of simultaneously injected autologous 99mTc-labelled erythrocytes (IgG-RBC) coated with a Rhesus anti-D antibody. In 17 studies, the number of antibody molecules coating the erythrocytes was 9000 (high coating) and in nine studies the number was 5000 (low coating).. 2. On gamma camera imaging, IgG-RBC uptake, at both levels of coating, could be visualized only in the spleen. HD-RBC were predominantly taken up by the spleen, although slight 111In activity was visible in the liver.. 3. The blood clearance of IgG-RBC was mono-exponential, whereas that of HD-RBC was bi-exponential. The reciprocal of the t1/2 (the time taken for the 3 min value to fall by 50%) of the HD-RBC clearance correlated rather poorly with the rate constant of the simultaneous IgG-RBC clearance (r = 0.47, P , 0.05 at high coating; r = 0.75, P , 0.05 at low coating). The rate constant of the second ...
WebMD provides common contraindications for Kit For Indium-111-Ibritumomab Intravenous. Find out what health conditions may be a health risk when taken with Kit For Indium-111-Ibritumomab Intravenous
TY - JOUR. T1 - 99mTc-labeled divalent and tetravalent CC49 single-chain Fvs. T2 - Novel imaging agents for rapid in vivo localization of human colon carcinoma. AU - Goel, A.. AU - Baranowska-Kortylewicz, J.. AU - Hinrichs, S. H.. AU - Wisecarver, J.. AU - Pavlinkova, G.. AU - Augustine, S.. AU - Colcher, D.. AU - Booth, B. J.M.. AU - Batra, S. K.. PY - 2001/1/1. Y1 - 2001/1/1. N2 - Radioimmunopharmaceutical agents enabling rapid high-resolution imaging, high tumor-to-background ratios, and minimal immunogenicity are being sought for cancer diagnosis and imaging. Genetic engineering techniques have allowed the design of single-chain Fvs (scFvs) of monoclonal antibodies (mAbs) recognizing tumor-associated antigens. These scFvs show good tumor targeting and biodistribution properties in vivo, indicating their potential as imaging agents when labeled with a suitable radionuclide. Methods: Divalent (sc(Fv)2) and tetravalent ([sc(Fv)2]2) scFvs of mAb CC49 were evaluated for ...
Radionuclide molecular imaging has the potential to improve cancer treatment by selection of patients for targeted therapy. Affibody molecules are a class of small (7 kDa) high-affinity targeting proteins with appreciable potential as molecular imaging probes. The NOTA chelator forms stable complexes with a number of radionuclides suitable for SPECT or PET imaging. A maleimidoethylmonoamide NOTA (MMA-NOTA) has been prepared for site-specific labeling of Affibody molecules having a unique C-terminal cysteine. Coupling of the MMA-NOTA to the anti-HER2 Affibody molecule Z(HER2:239S) resulted in a conjugate with an affinity (dissociation constant) to HER2 of 72 pM. Labeling of [MMA-NOTA-Cys(61)]-Z(HER2:239S) with In-111 gave a yield of ,95% after 20 min at 60 degrees C. In vitro cell tests demonstrated specific binding of [In-111-MMA-NOTA-Cys(61)]-Z(HER2:239S) to HER2-expressing cell lines. In mice bearing prostate cancer DU-145 xenografts, the tumor uptake of [In-111-MMA-NOTA-Cys(61)]-Z(HER2:239S) ...
[105 Pages Report] Check for Discount on United States Indium Sales Market Report 2021 report by QYResearch Group. This report studies sales (consumption) of Indium in USA market,...
Our previous studies have indicated that the optimal dosage ratio of pretargeting antibody to effector is proportional to their maximum percent tumour accumulations (MPTAs). This study quantitatively describes how both MPTAs and their ratio change wi
Platelets labeled with indium-111 have been used successfully as a marker of active thrombosis in man. To establish the diagnostic accuracy of platelet scintigraphy in comparison to contrast venography in the diagnosis of acute lower limb venous thrombosis, we evaluated 103 consecutive patients divided into two groups. Platelets were labeled by the indium-111 oxine method. Patients from group I (n = 73, 56 had venograms) were asymptomatic and underwent platelet scintigraphy 1.1 +/- 0.6 days (mean +/- 1 SD) after a major orthopedic procedure. Patients from group II (n = 30, all had venograms) were symptomatic and underwent platelet scintigraphy 1.2 +/- 1.7 days after venography. In group II, 15 patients with positive findings on contrast venography were treated with intravenous heparin; five others with positive venograms did not receive heparin until platelet scintigraphy was completed. Both platelet scintigraphy and contrast venography were evaluated by two blinded observers. Only studies with ...
We performed radionuclide scanning after the intravenous injection of human IgG labeled with indium-111 in 128 patients with suspected focal sites of inflammation. Localization of 111In-labeled IgG correlated with clinical findings in 51 infected patients (21 with abdominal or pelvic infections, 11 with intravascular infections, 7 with pulmonary infections, and 12 with skeletal infections). Infecting organisms included gram-positive bacteria, gram-negative bacteria, Pneumocystis carinii, Mycoplasma pneumoniae, and Candida albicans. No focal localization of 111In-labeled IgG was observed in 63 patients without infection. There were five false negative results, and nine results were unusable. Serial scans were carried out in eight patients: continued localization correctly predicted relapse in six, and the absence of localization indicated resolution in two. To determine whether 111In-labeled IgG localization was specific for inflammation, we studied 16 patients with cancer. Focal localization ...
Looking for focal infection? Find out information about focal infection. Infection in a limited area, such as the tonsils, teeth, sinuses, or prostate Explanation of focal infection
The Agg+ strain of S. sanguis induces platelet aggregation or clotting in vivo as predicted by the in vitro data. Aggregation in vitro is all-or-none with a dose-dependent delay (23). In vitro, rabbit platelets aggregate in response to the Agg+ strain in about two minutes. The experiments in vivo had been designed to record hemodynamic and cardiopulmonary responses upon a 1-min infusion of S. sanguis. Direct evidence for platelet aggregation or clotting in vivo include thrombocytopenia and, when compared to the Agg− strain, accumulation of 111Indium-labeled platelets in the lungs (Fig. 5), but not in the spleen. Platelets normally clear from the circulation to the spleen, but the 111Indium-labeled platelets used as tracers do not. The frequency and extent of manifestations of platelet clotting in vivo increase directly with the dose of inoculated Agg+S. sanguis.. Changes in heart rate and blood pressure occur more rapidly than would be predicted by the two minute lag time for in vitro platelet ...
An object hereof is to provide a method of making, a gap, which can provide good electron-emitting properties, simply, with low electric power and in short time. A method of fabricating an electron-emitting device, including a process of flowing a current in electroconductive film containing first particles and second particles including resistance lower than resistance of the first particle and thereby forming a gap in a portion of the above described electroconductive film, wherein the ratio of the above described first particle contained in the above described film is not less than 2% and not more than 30% and the ratio of resistance of the above described first particle to resistance of the above described second particle is not less than 5 and not more than 1000.
We have examined the possible mechanisms of resistance to the epidermal growth factor receptor (EGFR) inhibitors in tumor cells with variable levels of EGFR. ZD1839 (Iressa) is a small-molecular-weight, ATP-mimetic that specifically inhibits the EGFR tyrosine kinase. A431 cell growth was markedly in …
INDIUM: If you look for indium on the periodic chart, you will see that it located right by tin (Sn) and lead (Pb) but it is a world away in terms of its properties. Indium...
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Optical limiting properties in CH2Cl2 solution of a series of axially substituted InTPP (indium tetraphenyl-porphyrin) and axially substituted InTTP (indium tetra-p-tolyl-porphyrin) are investigated using a 532 nm laser with a pulse duration of 5 ns. The axial substitutions include -Cl, -SCN, -SPh and -SPh(p-Me). The optical limiting measurements reveal that the optical limiting properties of the indium porphyrins are greatly influenced by the axially attached functional groups. A limiting threshold of 0.18 J/cm2 is achieved for TTPInSCN, which is the best optical limiting material in this report. Z-scan experiments are also conducted and confirm that the good optical limiting performance of these indium porphyrins is due to the large value of σex/σg ...
1. The intrasplenic kinetics of granulocytes, isolated in plasma and labelled in plasma with 111In-tropolonate, have been studied in normal subjects, patients with negative studies for inflammatory disease and patients with positive studies, with the aim of identifying the nature of splenic activity seen after 111In-labelled granulocyte administration.. 2. Up to 40 min after injection, 111In activity was visible only in major blood vessels, liver and spleen, with slight, abnormal activity visible in most of those with positive scans. The time courses of uptake of hepatic and splenic activity were different, with liver activity rapidly reaching a plateau and splenic activity increasing mono-exponentially to a plateau achieved between 20 and 40 min.. 3. The clear difference between the shapes of the hepatic and splenic uptake curves and the magnitude of the splenic uptake rate constant indicated that splenic activity represented reversible uptake.. 4. The application of deconvolution analysis to ...
The MoAb E4 is a promising radiotracer for prostate cancer and may be used in radioimmunotherapy. As in earlier studies, TS1 shows significant radioimmunolocalization into necrotic tumor tissue, which also exists in prostate cancer.. ...
TY - JOUR. T1 - Synthesis, crystal and molecular structure of the first indium trihydride complex, [InH3{CN(Pri)C2Me2N(Pr i)}]. AU - Hibbs, David E.. AU - Hursthouse, Michael B.. AU - Jones, Cameron. AU - Smithies, Neil A.. PY - 1998/4/21. Y1 - 1998/4/21. N2 - The reaction of either [InH3(NMe3)] or LiInH4 with an excess of the imidazol-2-ylidene carbene, :CN(Pri)C2Me2N-(Pri), affords the first example of an indium trihydride complex, [InH3{CN(PriMe2N(Pri)}], the X-ray crystal structure of which is described.. AB - The reaction of either [InH3(NMe3)] or LiInH4 with an excess of the imidazol-2-ylidene carbene, :CN(Pri)C2Me2N-(Pri), affords the first example of an indium trihydride complex, [InH3{CN(PriMe2N(Pri)}], the X-ray crystal structure of which is described.. UR - http://www.scopus.com/inward/record.url?scp=0002911950&partnerID=8YFLogxK. U2 - 10.1039/a801118d. DO - 10.1039/a801118d. M3 - Article. AN - SCOPUS:0002911950. SP - 869. EP - 870. JO - Chemical Communications. JF - Chemical ...
Indium Corporation is a worldwide manufacturer of indium compounds and specialty inorganic compounds for a vast array of applications.
A novel affinity system for a two-phase delivery of radionuclides to tumor cells has been developed. In the first phase, a nontoxic bivalent monoclonal antibody conjugated to an enzyme is targeted to the tumor cells. In the second phase, a radionuclide-derivatized enzyme inhibitor, specific for the enzyme conjugated to the antibody, is administered. The model system selected for this study is the recombinant human enzyme dihydrofolate reductase (rhDHFR) and its high-affinity competitive inhibitor methotrexate (MTX). MTX was labeled with a radionuclide by covalent attachment of diethylenetriaminepentaacetic acid (DTPA) complexed with 111In. Using the γ-carboxyl residue of MTX for the attachment of DTPA, binding of the inhibitor to rhDHFR was not affected. The inhibitory activities of nonderivatized MTX and DTPA-MTX were indistinguishable. Human K562 erythroleukemia cells were used to evaluate under in vitro conditions the DHFR-MTX affinity system for the delivery of 111In-labeled DTPA-MTX to ...
Anti-EGFR Affibody® Molecule Affibody® Molecule datasheet (ab95116). Abcam offers quality products including antibodies, assays and other reagents.
A 36-year-old, Hispanic man died at a pork processing plant in central Iowa mid-winter of 2004. The victim had his feet entangled in an inclined, auger conveyor when it started. He was retrieving hardware or pieces of metal that had fallen into the auger during dismantling of conveying equipment and metal decking above the auger earlier that day and the day before. In an adjacent room the supervis
Page contains details about indium sulfide film . It has composition images, properties, Characterization methods, synthesis, applications and reference articles : nano.nature.com
Materion Advanced Chemicals Indium oxide; Purity: 99.999, CAS 1312-43-2, Materion Item Number SS-236. Call 419-289-9800 to order.
Our client, a 21-year-old farmer, was working on his 1969 Ford New Holland combine when an accident cost him his leg. He was using the machine to harvest and thresh wheat. In this type of combine, after the wheat is collected, the machine separates the heads from the straw and deposits the heads in a holding tank. The separation is facilitated by two rotating augers, a leveling auger and a discharge auger. They help to move the grain through the machine. At the time of the accident, the discharge auger was clogged, and our client was trying to reach a stick to fix it. As he leaned forward, however, his shirt was caught on the bolt of the leveling auger, and he was pulled down into the tank. His foot slipped beneath the discharge augers shield and was severely injured. He had to have his leg amputated below the knee. We argued that the combines protruding bolt was defective, the shields insufficient, and the manufacturers manual deficient in explaining how to safely fix discharge auger clogs. ...
AnazaoHealth®, Anazao®, Create, Heal, Live.®, the Compass, and Zāo® are registered trademarks of AnazaoHealth Corporation.. ...
Compositions and methods for treating and imaging vulnerable plaque and other inflammatory conditions in a patient rely on the delivery of conversion electron-emitting sources and other radionuclides
Neuroendokrine gastroenteropankreatische (NE-GEP) Tumore exprimieren Somato-statin-Rezeptoren mit hoher Dichte und Affinität [1]. Diese Rezeptoren können in vivo mittels eines Indium-111-markierten...
TY - JOUR. T1 - Determination of the immunoreactive fraction of radiolabeled monoclonal antibodies directed against intracellular antigens. AU - Haisma, Hidde J.. AU - Pinedo, H. M.. AU - Silva, Carlos A.. AU - Boven, Epie. PY - 1992/9/18. Y1 - 1992/9/18. N2 - For investigations involving monoclonal antibodies (mAbs) against cellular antigens cell binding assays are routinely used to determine the immunoreactive fraction after radiolabeling. In general, surface antigens are targets for radioimmunodetection, but recent studies indicate that intracellular determinants may also prove useful for this purpose. Thus, there is a need to adapt the regular cell binding assay for use with antibodies directed against cytoplasmic antigens. Here we describ a fixation method which permits such mAbs to bind to cell surfaces as well as to intracellular determinants. Moreover, the procedure may be used for antigens that are sensitive to the commonly used aldehyde fixatives. The method is illustrated with two ...
Mounting evidence shows that the urokinase plasminogen activator (uPA) and its receptor (uPAR) play a central role in tumor progression. 120 h p.i. In vivo uPA specificity of 89Zr-Df-ATN-291 was confirmed by successful pharmacological blocking of tumor uptake with ATN-291 in U87MG tumors. Akap7 Although the detailed mechanisms behind [19], and more recently, an 111In-labeled antibody adopted for prostate cancer imaging with remarkable tumor accumulation [20]. Our goal was to investigate a novel probe for effective targeting and imaging of the uPA/uPAR system in cancer with excellent targeting specificity and image contrast. To achieve this goal, 89Zr-labeled Bortezomib ATN-291 (i.e., 89Zr-Df-ATN-291; Df is abbreviated for deferoxamine) was used as an immunoPET probe. 89Zr (t1/2 = 78.4 h) was selected as the radiolabel in this study to provide a longitudinal evaluation on the interaction between ATN-291 and different tumor types [21]. To accomplish this goal, various studies were carried out to ...
Mounting evidence shows that the urokinase plasminogen activator (uPA) and its receptor (uPAR) play a central role in tumor progression. 120 h p.i. In vivo uPA specificity of 89Zr-Df-ATN-291 was confirmed by successful pharmacological blocking of tumor uptake with ATN-291 in U87MG tumors. Akap7 Although the detailed mechanisms behind [19], and more recently, an 111In-labeled antibody adopted for prostate cancer imaging with remarkable tumor accumulation [20]. Our goal was to investigate a novel probe for effective targeting and imaging of the uPA/uPAR system in cancer with excellent targeting specificity and image contrast. To achieve this goal, 89Zr-labeled Bortezomib ATN-291 (i.e., 89Zr-Df-ATN-291; Df is abbreviated for deferoxamine) was used as an immunoPET probe. 89Zr (t1/2 = 78.4 h) was selected as the radiolabel in this study to provide a longitudinal evaluation on the interaction between ATN-291 and different tumor types [21]. To accomplish this goal, various studies were carried out to ...
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207398-97-8,Indium(III) nitrate hydrate, 99.999% trace metals basis,Indium(III) nitrate hydrate,Indium(III) nitrate hydrate, 99.99% trace metals basis,MFCD00149742
TY - JOUR. T1 - Site-specific radioiodination of HER2-targeting affibody molecules using 4-iodophenethylmaleimide decreases renal uptake of radioactivity. AU - Strand, Joanna. AU - Nordeman, Patrik. AU - Honarvar, Hadis. AU - Altai, Mohamed. AU - Orlova, Anna. AU - Larhed, Mats. AU - Tolmachev, Vladimir. N1 - Publisher Copyright: © 2014 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA. Copyright: Copyright 2017 Elsevier B.V., All rights reserved.. PY - 2015/4/1. Y1 - 2015/4/1. N2 - Affibody molecules are small scaffold-based affinity proteins with promising properties as probes for radionuclide-based molecular imaging. However, a high reabsorption of radiolabeled Affibody molecules in kidneys is an issue. We have shown that the use of 125I-3-iodo-((4-hydroxyphenyl)ethyl)maleimide (IHPEM) for site-specific labeling of cysteine-containing Affibody molecules provides high tumor uptake but low radioactivity retention in kidneys. We hypothesized that the use of 4-iodophenethylmaleimide ...
Indium, 99.99% (trace metal basis), foil, 0.127mm thick, ACROS Organics™ 2.3g Indium, 99.99% (trace metal basis), foil, 0.127mm thick, ACROS Organics™ Indium
A method has been developed to characterize large populations of individual respirable particles. With the use of custom data collection and data correlation computer software, the same set of particles can be analyzed in multiple instruments. The method is demonstrated by the analysis of a sample of hard-metal particles. A series of particles are analyzed by Auger electron spectroscopy, and then
UCL Discovery is UCLs open access repository, showcasing and providing access to UCL research outputs from all UCL disciplines.
Indium In-111 ProstaScint®. Information for Physicians. Diagnostic imaging for prostate cancer with In-111 ProstaScint® is easier with AnazaoHealth.. AnazaoHealth provides In-111 radiolabeled ProstaScint as a unit dose vial compounded for your patient.. Imaging with In-111 ProstaScint® serves as a noninvasive test to evaluate soft tissue outside the prostate area for metastatic disease. In-111 ProstaScint® provides information that complements PSA, Gleason score and clinical stage.. Scans using In-111 ProstaScint® provide information that can help identify which course of treatment is most appropriate for your patient. It can also help detect lesions not visible by CT or MRI scans.. Having the ability to see what is needed to heal your patient is imperative. In-111 ProstaScint® is clearly the better choice.. ProstaScint® is a registered trademark of EUSA Pharma (JSA), Inc.. Please contact AnazaoHealth for information about these products.. ...
As announced in the Indium press release on Nov. 24th the Indium Corporation of America has introduced 1075-EXR 46 wave solder flux specifically designed to meet the process demands of Pb-Free manufacturing.
Immunoscintigraphy of carcinomas in the area of the head-neck with technetium-99m marked monoclonal antibody 174H.64. A new diagnostic procedure]. HNO. 1994 Sep; 42(9):546-52 ...
Research proven ADAM15 Rabbit Polyclonal IgG Antibody. Immunohistochemistry, Western Blot, Immunocytochemistry, and Immunofluorescence applications. Human, mouse, and rat specificity
Anti-Insulin Affibody® Molecule Affibody® Molecule datasheet (ab31906). Abcam offers quality products including antibodies, assays and other reagents.
Indium metal is very versatile. It has a low melting point and high boiling point and has a variety of properties and applications.
Autori: A.P. Rambu, D. Sirbu, M. Dobromir, G. G. Rusu. Editorial: Solid State Sciences, 14(10) , p.1543, 2012.. Rezumat:. Cuvinte cheie: Indium oxide, Structural characteristics, Electronic transport mechanism. ...
Each PerkinElmer Indium (In) Pure Grade Atomic Spectroscopy Calibration Standard is supplied with a comprehensive Certificate of Analysis.
Indium Corporation announces that Brian Reid has joined the company as vice president of operations. Reid is responsible for managing operations to achieve superior productivity, efficiency, quality, capability, and delivery.
Fingerprint Dive into the research topics of Electrical and optical properties of indium zinc oxide (IZO) thin films by continuous composition spread. Together they form a unique fingerprint. ...
INTRODUCTION: A zinc-dipicolylamine analog (Zn-DPA) conjugated with a fluorophore (PSVue(R)794) has been shown to image bacterial infections in mice. However, radiolabeled Zn-DPA has not previously been considered for nuclear imaging of infection. METHODS: Both 111In-labeled DOTA-biotin and Zn-DPA-biotin were combined using streptavidin (SA) as a noncovalent linker. Mice injected intramuscularly with Streptococcus pyogenes (infection model) or with lipopolysaccharide (LPS) (inflammation model) were coinjected intravenously with 6 mug of DPA as PSVue794 and as 111In-DOTA-biotin/SA/biotin-Zn-DPA. Periodic fluorescent and SPECT (single photon emission computed tomography)/CT (computed tomography) images were acquired, and biodistributions were obtained at 22 h. RESULTS: Histological examination confirmed the validity of both the infection and inflammation animal models. Both the whole-body optical and nuclear images showed obvious accumulations in the target thigh in both models at all time points. At 22 h
ECAT Foundation , P.O. Box 107 , 2250 AC Voorschoten , The Netherlands , Email: [email protected] , T: +31 (0) 71 3030 910 , F: +31 (0) 71 3030 ...
The synthesis of indium nitride nanoparticles and their use for the tuned emission in the near infra-red and visible spectral ...
Утром 27 августа разработчики выпустили патч 7.27d для Dota 2. Изменения коснулись некоторых предметов и ряда героев, в том чи...
If the drug contains a radioisotope, the name of the isotope precedes the name of the antibody. Consequently, indium (111In) ... A chelator for binding a radioisotope can be attached. Pendetide, a derivative of pentetic acid, is used for example in ... capromab pendetide is the name for the above example including indium-111. Emil von Behring and Kitasato Shibasaburō discovered ... merpentan being a chelator that links the antibody nofetumomab to the radioisotope technetium-99m. Rozrolimupabis a polyclonal ...
Technetium-99m, indium-111, and iodine-131 are common radioisotopes used for these purposes, with many others used as well. ... as a platform for combining multiple copies of targeting vectors and effectors in order to selectively deliver radioisotopes to ...
See the list below; in two noted cases (indium and rhenium), the long-lived radionuclide is actually the most abundant isotope ... Non-mononuclidic elements are marked with an asterisk, and the long-lived primordial radioisotope given. In two notable cases ( ... These elements are vanadium, rubidium, indium, lanthanum, europium, rhenium and lutetium. ... indium and rhenium), the highest abundance naturally occurring isotope is the mildly radioactive one, and in the case of ...
Certain tests, such as the Schilling test and urea breath test, use radioisotopes but are not used to produce a specific image ... Examples are gallium scans, indium white blood cell scans, iobenguane scan (MIBG) and octreotide scans. The MIBG scan detects ... where radioisotopes attached to drugs that travel to a specific organ or tissue (radiopharmaceuticals) are taken internally and ...
Of elements with at least one stable isotope, only indium and rhenium likewise have a radioisotope in greater abundance than a ... The longest-lived artificial radioisotope of tellurium is 121Te with a half-life of about 19 days. Several nuclear isomers have ... The very-long-lived radioisotopes 128Te and 130Te are the two most common isotopes of tellurium. ...
For three chemical elements, indium, tellurium, and rhenium, a very long-lived radioactive primordial nuclide is found in ... Cadmium, tellurium, xenon, neodymium, samarium and uranium each have two primordial radioisotopes (113 Cd , 116 Cd ; 128 Te , ... and xenon each have two primordial radioisotopes). The radionuclides are listed in order of stability, with the longest half- ... These 34 primordial nuclides represent radioisotopes of 28 distinct chemical elements (cadmium, neodymium, samarium, tellurium ...
Very few indium-containing minerals are known, all of them scarce: an example is indite. Indium is found in several zinc ores, ... Some radioisotopes have important roles in scientific research; a few are used in the production of goods for commercial use or ... Indium and its heavier homologues have no biological role, although indium salts in small doses, like gallium, can stimulate ... while aluminium and indium are monoisotopic, having only one, although most indium found in nature is the weakly radioactive ...
The peptide receptor may be bound to lutetium-177, yttrium-90, indium-111 and other isotopes including alpha emitters. This is ... is a type of radioisotope therapy (RIT) in which a peptide or hormone conjugated to a radionuclide or radioligand is given ... often indium-111, to detect larger lesions with tumor cells that are avid for octreotide.[citation needed] Somatostatin ...
However, in the cases of three elements (tellurium, indium, and rhenium) the most abundant isotope found in nature is actually ... Scientists estimate that the elements that occur naturally on Earth (some only as radioisotopes) occur as 339 isotopes ( ... Some isotopes/nuclides are radioactive, and are therefore referred to as radioisotopes or radionuclides, whereas others have ... Nuclear medicine and radiation oncology utilize radioisotopes respectively for medical diagnosis and treatment. Abundance of ...
... radioisotope occurring in their natural abundance. These elements are vanadium, rubidium, indium, lanthanum, europium, lutetium ...
Indium salts are toxic if more than few milligrams are ingested and will affect the kidneys, liver, and heart. Cisplatin (PtCl2 ... heavy metals are also employed as spallation targets for the production of neutrons or radioisotopes such as astatine (using ... Gallium, indium, and arsenic; and copper, iridium, and platinum are used in LEDs (the latter three in organic LEDs). Niche uses ... Gold, silver, and platinum are used in jewellery as are (for example) nickel, copper, indium, and cobalt in coloured gold. Low- ...
... of which the stable isotope is less abundant in nature than the long-lived primordial radioisotopes. The stablest artificial ... Indium has many semiconductor-related applications. Some indium compounds, such as indium antimonide and indium phosphide, are ... The stable indium isotope, indium-113, is one of the p-nuclei, the origin of which is not fully understood; although indium-113 ... Indium-115 makes up 95.7% of all indium. Indium is one of three known elements (the others being tellurium and rhenium) ...
Gamma emitter radioisotopes". Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials ... Indium-111 (111In) is a radioactive isotope of indium (In). It decays by electron capture to stable cadmium-111 with a half- ... Isotopes of indium Indium white blood cell scan Table of Radionuclides, Vol. 3 (PDF). Bureau international des poids et mesures ... Indium-111 chloride (111InCl) solution is produced by proton irradiation of a cadmium target (112Cd(p,2n) or 111Cd(p,n)) in a ...
... (trade name Myoscint) is a mouse monoclonal antibody labelled with the radioisotope Indium-111. It was ...
It was the Fab' fragment of a mouse monoclonal antibody labelled with the radioisotope indium-111 for the diagnosis of ... Indium (111In) biciromab (INN, trade name FibriScint, developed by Centocor) was a drug targeting fibrin, a protein involved in ...
Other than 115In, the longest-lived radioisotope is 111In, with a half-life of 2.8047 days. All other radioisotopes have half- ... Indium-111 is also used in indium white blood cell scans, which use nuclear medical techniques to search for hidden infections ... Indium-111 is used medically in nuclear imaging, as a radiotracer nuclide tag for gamma camera localization of protein ... Indium (49In) consists of two primordial nuclides, with the most common (~ 95.7%) nuclide (115In) being measurably though ...
... tagged with the radioisotope Indium-111, and then injected intravenously into the patient. The tagged leukocytes subsequently ... The indium white blood cell scan, is a nuclear medicine procedure in which white blood cells (mostly neutrophils) are removed ... However, indium leukocyte imaging is better at localizing acute (i.e., new) infections, where live neutrophils are still ... Both the gallium scan and indium-111 white blood cell imaging may be used to image fever of unknown origin (elevated ...
... is a mouse monoclonal antibody linked to pentetate which acts as a chelating agent for the radioisotope indium-111. The drug is ... Indium (111In) altumomab pentetate (INN) (USP, indium In 111 altumomab pentetate; trade name Hybri-ceaker) ...
... usually indium-lead) are more suitable for soldering thicker gold layer as the dissolution rate of gold in indium is much ... Radioisotopes undergoing alpha decay are a concern due to their tendency to cause soft errors. Polonium-210 is especially ... Lead-free solders in commercial use may contain tin, copper, silver, bismuth, indium, zinc, antimony, and traces of other ... Lead, and to some degree tin, as used in solder contains small but significant amounts of radioisotope impurities. ...
Indium is not known to be used by any organism. In a similar way to aluminium salts, indium(III) ions can be toxic to the ... The radioisotope iodine-131, which has a high fission product yield, concentrates in the thyroid, and is one of the most ... Indium's current primary application is to form transparent electrodes from indium tin oxide in liquid crystal displays and ... Indium was discovered in 1863 and named for the indigo blue line in its spectrum that was the first indication of its existence ...
Manual for reactor produced radioisotopes (PDF). International Atomic Energy Agency. 2003 [2010-05-13].. ... The Boron Elements: Boron, Aluminum, Gallium, Indium, Thallium. Rosen Publishing Group. 2009: 14. ISBN 978-1-4358-5333-1.. ... Chemistry of aluminium, gallium, indium, and thallium. Springer. 1993: 90 and 106. ISBN 978-0-7514-0103-5.. ...
The radioisotope thallium-201 (as the soluble chloride TlCl) is used in small amounts as an agent in a nuclear medicine scan, ... Like indium, thallium cyclopentadienyl compounds contain thallium(I), in contrast to gallium(III). Thallium (Greek θαλλός, ... The most useful radioisotope, 201Tl (half-life 73 hours), decays by electron capture, emitting X-rays (~70-80 keV), and photons ... 204Tl is the most stable radioisotope, with a half-life of 3.78 years. It is made by the neutron activation of stable thallium ...
The drug consists of exametazime as a chelating agent for the radioisotope technetium-99m. Both enantiomeric forms of ... "Comparison of 99m technetium hexamethylpropylene-amine oxime labelled leucocyte with 111-indium tropolonate labelled ...
... indium radioisotopes MeSH D01.496.749.474 - iodine radioisotopes MeSH D01.496.749.474.665 - serum albumin, radio-iodinated MeSH ... iron radioisotopes MeSH D01.496.749.540 - krypton radioisotopes MeSH D01.496.749.560 - lead radioisotopes MeSH D01.496.749.590 ... xenon radioisotopes MeSH D01.496.749.960 - yttrium radioisotopes MeSH D01.496.749.980 - zinc radioisotopes MeSH D01.496.807.800 ... xenon radioisotopes MeSH D01.496.943.800 - yttrium radioisotopes MeSH D01.496.966.800 - zinc radioisotopes MeSH D01.524.500.040 ...
Cadmium-113m is a cadmium radioisotope and nuclear isomer with a half-life of 14.1 years. In a normal thermal reactor, it has a ... The primary decay product before 112Cd is element 47 (silver) and the primary product after is element 49 (indium). mCd - ...
Indium gallium arsenide[edit]. Indium gallium arsenide (InGaAs) is a compound III-V semiconductor. It can be applied in two ... A TPV radioisotope converter with 20% efficiency was demonstrated that uses a tungsten emitter heated to 1350 K, with tandem ... Indium gallium arsenide antimonide[edit]. Indium gallium arsenide antimonide (InGaAsSb) is a compound III-V semiconductor. (Inx ... Indium phosphide arsenide antimonide[edit]. The InPAsSb quaternary alloy has been grown by both OMVPE and LPE. When lattice- ...
They can be administered alone or be linked (conjugated) to anticancer drugs, radioisotopes, or other biologic response ... either yttrium-90 or indium-111) CD22. Approximately 85% of DLBCLs express CD22. It is expressed on pre-B and mature B cells, ...
Tin was the plant's main product; it also produced silver, cadmium, lead, copper, antimony, bismuth, indium, and gold. The ... a radioisotope with a half life of about 140 days), thought to be produced via radioactive decay of naturally occurring ... Alfantazi, A. M.; Moskalyk, R. R. (2003). "Processing of indium: A review". Minerals Engineering. 16 (8): 687. doi:10.1016/ ...
Radioisotope renography. *Sestamibi parathyroid scintigraphy. *Radioactive iodine uptake test. *Bone scintigraphy. * ...
Indium Tin Antimony Tellurium Iodine Xenon Caesium Barium Lanthanum Cerium Praseodymium Neodymium Promethium Samarium Europium ... Radioisotopes of caesium require special precautions: the improper handling of caesium-137 gamma ray sources can lead to ... All of the alkali metals except lithium and caesium have at least one naturally occurring radioisotope: sodium-22 and sodium-24 ... The intermetallic compounds of the alkali metals with the heavier group 13 elements (aluminium, gallium, indium, and thallium ...
Radioisotope renography. *Sestamibi parathyroid scintigraphy. *Radioactive iodine uptake test. *Bone scintigraphy. * ...
Radioisotope renography(英语:Radioisotope renography). *Sestamibi parathyroid scintigraphy(英语:Sestamibi parathyroid scintigraphy) ... Indium-111 WBC scan(英语:Indium-111 WBC scan). 3D / ECT(英语:emission computed tomography). ...
Indium Tin Antimony Tellurium Iodine Xenon Caesium Barium Lanthanum Cerium Praseodymium Neodymium Promethium Samarium Europium ... 27 radioisotopes have been observed, with the most stable ones being 169Yb with a half-life of 32.0 days, 175Yb with a half- ...
Indium 1863 F. Reich and T. Richter 1867 T. Richter Reich and Richter First identified it in sphalerite by its bright indigo- ... Marinsky, J. A.; Glendenin, L. E.; Coryell, C. D. (1947). "The chemical identification of radioisotopes of neodymium and of ...
... radioisotope Radium Radon Radon fluoride Raman spectroscopy Raoult's law Redox Reduction Reflux Reversible reaction Rhazes ... ice Idocrase Illite Ilmenite Ilya Prigogine Indium infrared spectroscopy Inorganic chemistry Intermolecular force International ... Svante Arrhenius Syenite Sylvite synthetic radioisotope systematic element name Tabun Talc Talcum Tantalite Tantalum Tanzanite ...
Indium Tin Antimony Tellurium Iodine Xenon Caesium Barium Lanthanum Cerium Praseodymium Neodymium Promethium Samarium Europium ... While most of germanium's radioisotopes decay by beta decay, 61. Ge. and 64. Ge. decay by β+. delayed proton emission.[46] 84. ... At least 27 radioisotopes have also been synthesized, ranging in atomic mass from 58 to 89. The most stable of these is 68. Ge ... "The distribution of gallium, germanium and indium in conventional and non-conventional resources - Implications for global ...
Radioisotope renography. *Sestamibi parathyroid scintigraphy. *Radioactive iodine uptake test. *Bone scintigraphy. * ...
Radioisotope renography. *Sestamibi parathyroid scintigraphy. *Radioactive iodine uptake test. *Bone scintigraphy. * ...
Indium Tin Antimony Tellurium Iodine Xenon Caesium Barium Lanthanum Cerium Praseodymium Neodymium Promethium Samarium Europium ... Fourteen radioisotopes have been characterized. The most stable are 15O with a half-life of 122.24 seconds and 14O with a half- ...
Indium Tin Antimony Tellurium Iodine Xenon Caesium Barium Lanthanum Cerium Praseodymium Neodymium Promethium Samarium Europium ... Fourteen radioisotopes have been characterized. The most stable are 15O with a half-life of 122.24 seconds and 14O with a half- ...
indium-111 & technetium-99m. 171 & 245. 67 hours. in vitro labelled leucocytes. 18. 360. 60. 64 x 64. 30 ... Radioisotope. Emission energy (keV). Half-life. Radiopharmaceutical. Activity (MBq). Rotation (degrees). Projections. Image ... On occasion, the radioisotope is a simple soluble dissolved ion, such as an isotope of gallium(III). Most of the time, though, ... SPECT is more widely available, because the radioisotope used is longer-lasting and far less expensive in SPECT, and the gamma ...
Radioisotope renography. *Sestamibi parathyroid scintigraphy. *Radioactive iodine uptake test. *Bone scintigraphy. * ...
Indium Tin Antimony Tellurium Iodine Xenon Caesium Barium Lanthanum Cerium Praseodymium Neodymium Promethium Samarium Europium ... Thirty radioisotopes have been characterised, which range in mass number from 209[22] to 238.[20] After 232Th, the most stable ... All of these isotopes occur in nature as trace radioisotopes due to their presence in the decay chains of 232Th, 235U, 238U, ... These rely on the fact that 232Th is a primordial radioisotope, but 230Th only occurs as an intermediate decay product in the ...
Indium Tin Antimony Tellurium Iodine Xenon Caesium Barium Lanthanum Cerium Praseodymium Neodymium Promethium Samarium Europium ... Twenty-eight radioisotopes have been characterized, the most stable being 105Ag with a half-life of 41.29 days, 111Ag with a ... indium (involving three adjacent elements on the periodic table) is useful in nuclear reactors because of its high thermal ...
Radioisotope renography. *Sestamibi parathyroid scintigraphy. *Radioactive iodine uptake test. *Bone scintigraphy. * ...
Indium Tin Antimony Tellurium Iodine Xenon Caesium Barium Lanthanum Cerium Praseodymium Neodymium Promethium Samarium Europium ... 19 radioisotopes have been characterized, with the most stable being 50Cr with a half-life of (more than) 1.8×1017 years, and ...
Indium Tin Antimony Tellurium Iodine Xenon Caesium Barium Lanthanum Cerium Praseodymium Neodymium Promethium Samarium Europium ... is also sometimes considered as a light radioisotope of hydrogen, due to the mass difference between the antimuon and the ... Downs, A. J.; Pulham, C. R. (1994). "The hydrides of aluminium, gallium, indium, and thallium: a re-evaluation". Chemical ... Hibbs, D. E.; Jones, C.; Smithies, N. A. (1999). "A remarkably stable indium trihydride complex: synthesis and characterisation ...
Indium Tin Antimony Tellurium Iodine Xenon Caesium Barium Lanthanum Cerium Praseodymium Neodymium Promethium Samarium Europium ... allowing the use of radioisotope rubidium-82 in nuclear medicine to locate and image brain tumors.[50] Rubidium-82 has a very ...
As the radioisotope undergoes positron emission decay (also known as positive beta decay), it emits a positron, an antiparticle ... BROWNELL G.L., Dave Marcum, B. HOOP JR., and D.E. BOHNING, "Quantitative dynamic studies using short-lived radioisotopes and ... Due to the short half-lives of most positron-emitting radioisotopes, the radiotracers have traditionally been produced using a ... Organic radiotracer molecules that will contain a positron-emitting radioisotope cannot be synthesized first and then the ...
Radioisotope renography. *Sestamibi parathyroid scintigraphy. *Radioactive iodine uptake test. *Bone scintigraphy. * ...
Indium. Tin. Antimony. Tellurium. Iodine. Xenon. Caesium. Barium. Lanthanum. Cerium. Praseodymium. Neodymium. Promethium. ... The most stable radioisotopes are 107Pd with a half-life of 6.5 million years (found in nature), 103Pd with 17 days, and 100Pd ... Eighteen other radioisotopes have been characterized with atomic weights ranging from 90.94948(64) u (91Pd) to 122.93426(64) u ...
The term radioisotope, which in its general sense refers to any radioactive isotope (radionuclide), has historically been used ... indium (111In) altumomab pentetate. indium In 111 altumomab pentetate. See also[edit]. *Radioactive tracer ... Some radioisotopes (for example gallium-67, gallium-68, and radioiodine) are used directly as soluble ionic salts, without ... The United States Pharmacopeia (USP) name gives the base drug name, followed by the radioisotope (as element symbol, space, ...
However the dose delivered by older DEXA radiation sources (which used radioisotopes rather than x-ray generators) could be as ...
Indium Tin Antimony Tellurium Iodine Xenon Caesium Barium Lanthanum Cerium Praseodymium Neodymium Promethium Samarium Europium ... Hg being the most abundant (29.86%). The longest-lived radioisotopes are 194. Hg with a half-life of 444 years, and 203. Hg ... Most of the remaining radioisotopes have half-lives that are less than a day. 199. Hg and 201. Hg are the most often studied ...
No information is available on the use of indium In 111 pentetate during breastfeeding. Because of the long half-life of indium ... Information in this record refers to the use of indium In 111 pentetate as a diagnostic agent. ... Indium Radioisotopes. Diagnostic Agents. Disclaimer: Information presented in this database is not meant as a substitute for ... Review Indium 111 Ibritumomab Tiuxetan[Drugs and Lactation Database (...]. Review Indium 111 Ibritumomab Tiuxetan. . Drugs and ...
Indium Radioisotopes. Grant support. *Wellcome Trust/United Kingdom. LinkOut - more resources. Full Text Sources. *Ingenta plc ...
Indium Radioisotopes / pharmacokinetics * Indium Radioisotopes / therapeutic use * Indium Radioisotopes / toxicity * Male * ...
INDIUM 111; INFLAMMATION; LABELLING; MAN; MYCOPLASMA; PATIENTS; RADIOISOTOPE SCANNING; ANIMALS; BETA DECAY RADIOISOTOPES; ... COUNTING TECHNIQUES; DAYS LIVING RADIOISOTOPES; DISEASES; ELECTRON CAPTURE RADIOISOTOPES; EUMYCOTA; FUNGI; GLOBULINS; INDIUM ... We performed radionuclide scanning after the intravenous injection of human IgG labeled with indium-111 in 128 patients with ... MINUTES LIVING RADIOISOTOPES; NUCLEI; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; PATHOLOGICAL CHANGES; PLANTS; PRIMATES; PROTEINS; ...
Indium Radioisotopes. Leukapheresis. Interleukin-2. Acquired Immunodeficiency Syndrome. AIDS-Related Complex. Zidovudine. ... At week 16, IL-2 is administered concurrently with Indium 111 labelled cells and the CD8+ lymphocytes - delivered by continuous ... During weeks 13 and 16, indium 111 radio labelled cells are injected to permit determination of the distribution and ... lymphocytes with Indium 111, and then scan the patients to determine the distribution of the CD8(+) lymphocytes in those who ...
Indium Radioisotopes. Unstable isotopes of indium that decay or disintegrate emitting radiation. In atoms with atomic weights ... Mobility and retention of indium and gallium in saturated porous media.. Transport of indium and gallium is reported in ... 111 Indium CHX-A DTPA Trastuzumab (Indium-Herceptin) for Imaging Breast Cancer ... Indium In 111 Pentetreotide in Treating Patients With Refractory Cancer. RATIONALE: Radiation therapy uses high-energy x-rays ...
Indium Radioisotopes * Magnetic Resonance Imaging / methods* * Male * Mice * Mice, Nude * Pentetic Acid ...
Gallium Radioisotopes. Indium. Lung / metabolism*, radionuclide imaging. Pentetic Acid / metabolism*. Sugar Acids / metabolism* ... 0/Chromium Radioisotopes; 0/Gallium Radioisotopes; 0/Sugar Acids; 11096-37-0/Transferrin; 60-00-4/Edetic Acid; 67-43-6/Pentetic ... Chromium Radioisotopes. Deferoxamine / metabolism*. Dextrans / metabolism*. Dogs. Edetic Acid / metabolism*. ... Acid; 70-51-9/Deferoxamine; 7440-26-8/Technetium; 7440-74-6/Indium; 87-74-1/alpha-glucoheptonic acid; 9004-54-0/Dextrans ...
Indium Radioisotopes / pharmacokinetics. Male. Mice. Mice, Nude. Morpholines / pharmacokinetics*. Morpholinos. Neoplasm ... 0/Antibodies, Neoplasm; 0/Antineoplastic Agents; 0/B72.3 antibody; 0/Indium Radioisotopes; 0/Morpholines; 0/Morpholinos; 0/ ...
Radioisotopes and radioopaque agents include gallium, technetium, indium, strontium, iodine, barium, and phosphorus. ...
Tens of millions of nuclear medicine procedures are performed each year, and demand for radioisotopes is increasing rapidly ... the use of radioisotopes for diagnostics, radiation therapy, radiopharmaceuticals and other beneficial medical uses of nuclear ... Indium-111 (2.8 d):. Used for specialist diagnostic studies, e.g. brain studies, infection and colon transit studies. Also for ... The global radioisotope market was valued at $9.6 billion in 2016, with medical radioisotopes accounting for about 80% of this ...
These materials are used as targets in reactors and accelerators to produce radioisotopes for basic and clinical research (see ... These enriched stable isotopes are used as target materials in the preparation of radioisotopes with particle accelerators and ... a For specific examples of radioisotope applications, refers to Chapters 3 and 4. ... Enriched stable isotopes are critical starting materials in the production of many widely used radioisotopes. ...
There the white blood cells are tagged with a radioactive substance (radioisotope) called indium. The cells are then injected ... Radioactive abscess scan; Abscess scan; Indium scan; Indium-labeled white blood cell scan; WBC scan ...
Useful cations include technetium, gallium, and indium. In the conjugates, either or both the specific binding substances can ... Radioisotope labeling is preferred, as it can be readily detected in vivo. ...
Gamma emitter radioisotopes". Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials ... Indium-111 (111In) is a radioactive isotope of indium (In). It decays by electron capture to stable cadmium-111 with a half- ... Isotopes of indium Indium white blood cell scan Table of Radionuclides, Vol. 3 (PDF). Bureau international des poids et mesures ... Indium-111 chloride (111InCl) solution is produced by proton irradiation of a cadmium target (112Cd(p,2n) or 111Cd(p,n)) in a ...
Indium (111In) imciromab (trade name Myoscint) is a mouse monoclonal antibody labelled with the radioisotope Indium-111. It was ...
The study involves attaching a radioisotope called Indium-111 to vitamin B-12. This work began at the Mayo Clinic. Continued ... "This study will also help us determine the highest dosage of the radioisotope that can be safely administered to lymphoma ...
111In-Zevalin is made up of the monoclonal antibody ibritumomab plus the radioisotope indium In 111. It binds to a protein ...
radioisotope. ) called indium. The cells are then injected back into a vein through another needle stick. ... Radioactive abscess scan; Abscess scan; Indium scan; Indium-labeled white blood cell scan; WBC scan ...
No compartmentalization of CSF flow by radioisotope indium In 111 or technetium Tc 99 DTPA flow study ...
For example, the detectable moiety may comprise or consist of a radioisotope, such as technitium-99m, indium-111, gallium-67, ... The method according to claim 70, wherein the radioisotope is selected from the group consisting of technitium-99m; indium-111 ... The method according to claim 69, wherein the cytotoxic or detectable moiety comprises or consists of a radioisotope. 71. The ... For example, the cytotoxic moiety may comprise or consist of a radioisotope, such as astatine-211, bismuth-212, bismuth-213, ...
A murine monoclonal antibody that targets the CD20 antigen, ibritumomab tiuxetan is chelated to the radioisotopes indium-111 or ...
Long life radioisotope-powered, voltaic-junction battery using radiation resistant materials US5322573A (en) * 1992-10-02. 1994 ... High‐efficiency indium tin oxide/indium phosphide solar cells. US7122733B2 (en) 2006-10-17. Multi-junction photovoltaic cell ... Triethyl-indium was added to the raw materials, controlling flowing rates of each gas, so that a p-Gax In1-x P layer having the ... Solar cells based on indium phosphide Download PDF Info. Publication number. US4591654A. US4591654A US06631091 US63109184A ...
Indium definition, a rare metallic element, soft, white, malleable, and easily fusible, found combined in various ore minerals ... A soft malleable metallic element found primarily in ores of zinc, used in making dental alloys and in its radioisotope forms ... Words nearby indium. indissoluble, indistinct, indistinctive, indistinguishable, indite, indium, indiv., indivertible, individ. ... indium. 1860-65; ,New Latin, equivalent to ind(icum) indigo + -ium-ium ...
Indium-111. Indium-111 (111In) octreotide and pentetreotide scans may differentiate lymphomas and other mediastinal masses from ... tagged to an appropriate radioisotope. Single-photon emission CT (SPECT) scanning and subtraction techniques improve detection. ... What is the role of indium-111 (111In) octreotide and pentetreotide scans in thoracic non-Hodgkin lymphoma (NHL) imaging? ...
Indium/diagnostic use. MESH. Iodine Radioisotopes/diagnostic use. MESH. Radioisotopes/diagnostic use. MESH. ...
Radionuclides tentatively on the list are copper-67, germanium-68, indium-111, palladium-103, rhenium-186, samarium-153, and ... The APT site could be a potential U.S. source of radioisotopes to be used in the manufacture of radiopharmaceuticals in nuclear ... Molybdenum will probably not be produced, despite the fact that much of the worlds supply of the short-lived radioisotope is ... Biomedical experts gather to discuss new medical radioisotope sources. @media screen and (max-width: 468px) { .video-detail . ...
"The radioisotope market is more complex than one might think, so developing our own client base would be difficult. This ... Examples of such isotopes are radioactive metal isotopes such as Technetium-99m, Zirconium-89, and Indium-111. This class of ... There are lots of opportunities for radioisotope research both for health and other applications," Rami said. ... forming an alliance with an industry partner to market radioisotopes on the global stage. Not only will this help create new ...
Various metals such as platinum, gold, silver or indium/tin oxide may be used for the electrodes. ... wherein the reporter is selected from a dye, fluorescent agent, chemiluminescent agent, chromophore, radio-isotope, and ...
The response of gammas and alpha ray has been tested by the irradiation of several radio-isotopes. The signal from alpha ... New radiation detector using the semi-insulating indium phosphide (InP) crystal was developed in the research, and some bulk ... Neutrinos / Neutrino Oscillation / Solar Neutrinos / Super-Kamiokande / indium / pp-^7Be neutrinos / Solid State Detector / 半導体 ... Development of pp-^7Be solar neutrino detector with indium crystal. Research Project ...
  • Unstable isotopes of indium that decay or disintegrate emitting radiation. (bioportfolio.com)
  • These enriched stable isotopes are used as target materials in the preparation of radioisotopes with particle accelerators and nuclear reactors and as biological tracers in biomedical research and clinical applications. (nap.edu)
  • Isotopes of indium Indium white blood cell scan Table of Radionuclides, Vol. 3 (PDF). (wikipedia.org)
  • In atoms with atomic weights 106-112, 113m, 114, and 116-124 are radioactive indium isotopes. (bvsalud.org)
  • Both Indium Isotopes are stable. (tracesciences.com)
  • Trace Sciences is your most reliable supplier of stable Indium Isotopes. (tracesciences.com)
  • Please contact us for other forms of Indium Isotopes available. (tracesciences.com)
  • The isotopes 111In, 113In used in radioisotope diagnosis. (avglob.biz)
  • Indium (111In) imciromab (trade name Myoscint) is a mouse monoclonal antibody labelled with the radioisotope Indium-111. (wikipedia.org)
  • 111In-Zevalin is made up of the monoclonal antibody ibritumomab plus the radioisotope indium In 111. (cancer.gov)
  • A murine monoclonal antibody that targets the CD20 antigen, ibritumomab tiuxetan is chelated to the radioisotopes indium-111 or yttrium-90. (medscape.com)
  • This class of products combines monoclonal antibodies, which are attracted to cancer, with radioisotopes that irradiate the target tissues. (diagnosticimaging.com)
  • Tumor pretargeting is obtained by using a bispecific monoclonal antibody [BsmAb, anti-CEA × anti-DTPA-indium complex (DTPA-In)] and pegylated radioactive liposomes containing a lipid-hapten conjugate (DSPE-PEG-DTPA-In). (frontiersin.org)
  • PROSTASCINT consists of Cytogen's proprietary PSMA-targeting monoclonal antibody, 7E11-C5, linked to the imaging radioisotope Indium-111. (salesandmarketingnetwork.com)
  • Indium In-111 imciromab pentetate is a mouse monoclonal antibody labelled with the radioisotope Indium-111 which was used for cardiac imaging under the trade name Myoscint, but was withdrawn in 1993. (drugbank.ca)
  • Indium 111 decays by electron capture with 173 keV and 245 keV gamma emissions and a physical half-life of 2.8 days. (nih.gov)
  • During weeks 13 and 16, indium 111 radio labelled cells are injected to permit determination of the distribution and pharmacokinetics of the infused cells. (clinicaltrials.gov)
  • The goal of this study was to investigate the pharmacokinetics, biodistribution, and correlation of Indium-111 radioactivity and vinorelbine concentration in the 111 In-VNB-liposome. (dovepress.com)
  • A significant positive correlation between the pharmacokinetics and biodistribution of 111 Indium radioactivity and vinorelbine in blood, spleen, and liver was found following administration of the 111 In-VNB-liposome. (dovepress.com)
  • Indium-111 (111In) is a radioactive isotope of indium (In). (wikipedia.org)
  • Also called 111In-ibritumomab tiuxetan and indium In 111-ibritumomab tiuxetan. (cancer.gov)
  • Indium-111 (111In)-oxine or Technetium-99m (99mTc)-hexamethylpropylene amine oxime (HMPAO) scintigraphy/SPECT has been a classical method to visualize leukocytes and is clinically used for evaluation of inflammation, infection or abscess since the mid-1970s 23-26. (minderheden.org)
  • Information in this record refers to the use of indium In 111 pentetate as a diagnostic agent. (nih.gov)
  • Diagnostic procedures using radioisotopes are now routine. (world-nuclear.org)
  • In developed countries (a quarter of the world population) about one person in 50 uses diagnostic nuclear medicine each year, and the frequency of therapy with radioisotopes is about one-tenth of this. (world-nuclear.org)
  • The most common radioisotope used in diagnosis is technetium-99 (Tc-99), with some 40 million procedures per year, accounting for about 80% of all nuclear medicine procedures and 85% of diagnostic scans in nuclear medicine worldwide. (world-nuclear.org)
  • Radioisotopes are an essential part of medical diagnostic procedures. (world-nuclear.org)
  • Indium-111 is commonly used in nuclear medicine diagnostic imaging by radiolabeling targeted molecules or cells. (wikipedia.org)
  • A soft malleable metallic element found primarily in ores of zinc, used in making dental alloys and in its radioisotope forms in diagnostic radiology. (dictionary.com)
  • Diagnostic nuclear medicine imaging involves dosing the patient with a very small amount of a gamma ray-emitting radioisotope. (merckvetmanual.com)
  • Prior to therapy, all patients received a diagnostic dose of hPAM4 labeled with the radioisotope, Indium-111, to ensure an acceptable distribution within the body and radiation dose to the pancreas for intended therapy. (bio-medicine.org)
  • 71. The method according to claim 70, wherein the radioisotope is selected from the group consisting of astatine-211, bismuth-212, bismuth-213, iodine-131, yttrium-90, lutetium-177, samarium-153 and palladium-109. (freepatentsonline.com)
  • Seven to nine days later, a second infusion of Rituxan is administered, followed by a dose of Zevalin carrying the therapeutic radioisotope yttrium-90. (diagnosticimaging.com)
  • Preclinical studies with PAM4 labeled with the radioisotope, Yttrium-90, demonstrated favorable tumor responses, which could be further improved when given in combination with gemcitabine. (bio-medicine.org)
  • The APT site could be a potential U.S. source of radioisotopes to be used in the manufacture of radiopharmaceuticals in nuclear medicine. (diagnosticimaging.com)
  • The combination of a radioisotope with a chemotherapeutic agent in a liposomal carrier (ie, Indium-111-labeled polyethylene glycol pegylated liposomal vinorelbine, [ 111 In-VNB-liposome]) has been reported to show better therapeutic efficiency in tumor growth suppression. (dovepress.com)
  • Nevertheless, the challenge remains as to whether this therapeutic effect is attributable to the combination of a radioisotope with chemotherapeutics. (dovepress.com)
  • In direct labelling, a marker or radioisotope such as indium-111 oxyquinoline or fludeoxyglucose F18 is placed inside or on the surface of the cellular therapeutic ex vivo. (bruker.com)
  • UV plasmonic properties of colloidal liquid-metal eutectic gallium-indium alloy nanoparticles. (bioportfolio.com)
  • Here, we experimentally demonstrate strong UV plasmonic resonances of eutectic gallium-indium (EGaIn) liquid-metal alloy nanoparticles suspended in ethanol. (bioportfolio.com)
  • Mobility and retention of indium and gallium in saturated porous media. (bioportfolio.com)
  • Transport of indium and gallium is reported in laboratory column experiments using quartz sand as a model porous medium representative of a groundwater system. (bioportfolio.com)
  • With increased use of indium and gallium. (bioportfolio.com)
  • Antimony follows closely in the track of gallium and indium , the upper ring of spheres being identical. (dictionary.com)
  • Flourine 18 fluorodeoxyglucose (FDG), iodine 131 ((131)I) methylnorcholestenol, and gallium 67 ((67)Ga) citrate, separately compacted into micro tubes, were inserted subcutaneously into a Wistar rat, and the distribution of the radioisotope compounds was determined with 3D imaging by using the Compton camera after the rat was sacrificed (ex vivo model). (sigmaaldrich.com)
  • Molybdenum will probably not be produced, despite the fact that much of the world's supply of the short-lived radioisotope is dependent on a single Canadian nuclear reactor ( SCAN 6/10/97). (diagnosticimaging.com)
  • What is an Indium Scan? (wise-geek.com)
  • A person's blood is drawn and tagged with indium-111 isotope then injected back into a vein for an indium scan. (wise-geek.com)
  • An indium scan, also known as a leukocyte scan or white blood cell (WBC) scan, is a type of nuclear scan in which a radioactive tracer is used to identify inflammation or infection in specific areas of the body. (wise-geek.com)
  • The indium scan is a multiple-step procedure conducted by a nuclear medicine technologist. (wise-geek.com)
  • A second indium scan procedure, or follow-up tests such as an MRI or CT scan , could be required to confirm the presence of infection or inflammation. (wise-geek.com)
  • An indium scan is a non-invasive and non-surgical procedure. (wise-geek.com)
  • An indium scan may be performed if a patient is experiencing liver inflammation. (wise-geek.com)
  • Risks inherent in the indium scan procedure are considered to be minimal. (wise-geek.com)
  • A patient should drink a large amount of water following an indium scan. (wise-geek.com)
  • An indium scan is typically prescribed when a doctor suspects that there could be infection or inflammation in some part of the body, particularly in the abdominal area. (wise-geek.com)
  • An abnormal result on the indium scan indicates the likelihood of an active infection or inflamed area, such as an abscess of the liver or other organs. (wise-geek.com)
  • An abnormal result on an indium scan may occur because the spleen tends to accumulate WBCs even when there is no active infection present. (wise-geek.com)
  • Upon labeling with radioisotope Indium-111, the ANP-PSi nanoparticles displayed a preferential accumulation and selectivity towards the endocardial layer of the ischemic heart. (helsinki.fi)
  • Members of the biomedical sciences community, as well as representatives of the radiopharmaceutical industry, are recommending that the production of medical radioisotopes be included in the APT site's charter. (diagnosticimaging.com)
  • New radiation detector using the semi-insulating indium phosphide (InP) crystal was developed in the research, and some bulk size of detector s with a volume of 49mm^2 with 0.5mm in thickness have been tested in a room temperature. (nii.ac.jp)
  • Markers, or radioisotopes, are useful for PET and SPECT imaging, and include examples such as Indium-111 oxyquinoline (indium oxine), zirconium-89 or fludeoxyglucose F18. (mpiresearch.com)
  • Indium oxide, In2O3, is a yellow powder which is formed on ignition of the hydroxide. (dictionary.com)
  • Critical temperature of superconductivity is t° 3,405°K. In contrast to magnesium, which is ignited at t° 623 °C, indium is able to withstand heat up to 800 °C, but after flashing flame violet-blue color with the formation of oxide. (avglob.biz)
  • In veterinary medicine, the most commonly used isotope is metastable technetium-99 ( 99m Tc), although radioactive iodine, indium, and thallium are also used in specific instances. (merckvetmanual.com)
  • 10. A probe as recited in claim 8, wherein said metal ion is a radioactive isotope of technetium or indium. (patentgenius.com)
  • Rarely, some people could experience an allergic reaction to the indium-111 isotope, which in extreme cases could lead to anaphylactic shock. (wise-geek.com)
  • There the white blood cells are tagged with a radioactive substance ( radioisotope ) called indium. (medlineplus.gov)
  • There is widespread awareness of the use of radiation and radioisotopes in medicine, particularly for diagnosis (identification) and therapy (treatment) of various medical conditions. (world-nuclear.org)
  • Over 10,000 hospitals worldwide use radioisotopes in medicine, and about 90% of the procedures are for diagnosis. (world-nuclear.org)
  • No information is available on the use of indium In 111 pentetate during breastfeeding. (nih.gov)
  • Phosphorus Radioisotopes" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (harvard.edu)
  • Also the results show that two organs spleen and stomach are at risk in Indium 111-rituximab therapy. (ac.ir)
  • A liquid chromatography tandem mass spectrometry system and gamma counter were used to analyze the concentration of vinorelbine and radioactivity of Indium-111. (dovepress.com)
  • Linear regression showed a good correlation ( r = 0.97) between Indium-111 radioactivity and vinorelbine concentration in the plasma of rats administered the 111 In-VNB-liposome. (dovepress.com)
  • The liposome efficiently encapsulated both vinorelbine and Indium-111, and showed a similar concentration-radioactivity time profile, indicating the correlation between chemotherapy and radiotherapy could be identical in the liposomal formulation. (dovepress.com)
  • In wolframite, arsenopyrite, pyrite concentration of indium is several grams per ton. (avglob.biz)
  • Indium-111 chloride (111InCl) solution is produced by proton irradiation of a cadmium target (112Cd(p,2n) or 111Cd(p,n)) in a cyclotron, as recommended by International Atomic Energy Agency (IAEA). (wikipedia.org)
  • In a separate experiment, indium 111((111)In) chloride and (131)I-methylnorcholestenol were injected into a rat intravenously, and copper 64 ((64)Cu) chloride was administered into the stomach orally just before imaging. (sigmaaldrich.com)
  • Brand Ин0000 comprises 99.9999% of chemically pure indium. (avglob.biz)
  • We performed radionuclide scanning after the intravenous injection of human IgG labeled with indium-111 in 128 patients with suspected focal sites of inflammation. (osti.gov)
  • We also found that the radioisotope signal of indium-111 labeled ATS, which was utilized for CRC detection in HCT-15-induced xenograft mice, was markedly enhanced in tumors as compared with non-ATS control. (elsevier.com)
  • The Indium-111, after decay, emits gamma rays with energies of 245 KeV and 171 KeV, and beta-radiation of 26 KeV. (ac.ir)
  • Its name comes from the spectroscopic lines of indium (Indigo). (avglob.biz)
  • Radioisotope-labeled somatostatin analogs are utilized for both tumor localization and peptide radionuclide therapy, with 68 Ga-DOTATATE and 177 Lu-DOTATATE respectively. (frontiersin.org)
  • The first and fourth injections were radiolabeled with indium-111 for gamma camera imaging.Of 40 patients screened, 25 of 34 (74%) assessable SCLC tumor samples were 3S193 positive by immunohistochemistry. (edu.au)
  • Here, we aimed to investigate the CA9 expression in serum and tumor from different stages of CRC patients and utilize sulfonamide derivative with indium-111 labeling as a probe for CRC nuclear imaging detection in vivo. (elsevier.com)
  • Once integrated within the genome, the reporter genes are transcribed into mRNA and translated and expressed as proteins that can be bound by a radioisotope for signal generation. (bruker.com)
  • In-111 is also applied in Indium white blood cell scans, which use nuclear medical techniques to search for hidden infections. (isosolutions.com)
  • This is followed by a dose of Zevalin labeled with indium-111, which can be tracked in the body with a gamma camera. (diagnosticimaging.com)
  • The location and distribution of the radioisotope within the body is then detected with a gamma camera, a device specifically designed to collimate and detect gamma rays. (merckvetmanual.com)
  • The radioisotope-labeled sulfonamide derivative (ATS) may be useful to apply in CRC patients for nuclear medicine imaging. (elsevier.com)
  • Many radioisotopes are made in nuclear reactors, some in cyclotrons. (nmmra.org)
  • Indium scans are not recommended for breastfeeding women. (wise-geek.com)