The external reproductive organ of males. It is composed of a mass of erectile tissue enclosed in three cylindrical fibrous compartments. Two of the three compartments, the corpus cavernosa, are placed side-by-side along the upper part of the organ. The third compartment below, the corpus spongiosum, houses the urethra.
An alkaloid found in opium but not closely related to the other opium alkaloids in its structure or pharmacological actions. It is a direct-acting smooth muscle relaxant used in the treatment of impotence and as a vasodilator, especially for cerebral vasodilation. The mechanism of its pharmacological actions is not clear, but it apparently can inhibit phosphodiesterases and it may have direct actions on calcium channels.
Endocrine System Diseases
Periodic Acid-Schiff Reaction
Sexual Dysfunction, Physiological
A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)
Intercellular signaling peptides and proteins that regulate the proliferation of new blood vessels under normal physiological conditions (ANGIOGENESIS, PHYSIOLOGICAL). Aberrant expression of angiogenic proteins during disease states such as tumorigenesis can also result in PATHOLOGICAL ANGIOGENESIS.
An Eph family receptor found abundantly in tissues of epithelial origin. It is expressed in a diverse array of tissues during embryonic development, suggesting that it may play a role in embryogenesis. In adult tissues high levels of the receptor are expressed in the LUNG; SKIN; SMALL INTESTINE and OVARY.
Highly specialized EPITHELIAL CELLS that line the HEART; BLOOD VESSELS; and lymph vessels, forming the ENDOTHELIUM. They are polygonal in shape and joined together by TIGHT JUNCTIONS. The tight junctions allow for variable permeability to specific macromolecules that are transported across the endothelial layer.
Complete or partial surgical removal of the prostate. Three primary approaches are commonly employed: suprapubic - removal through an incision above the pubis and through the urinary bladder; retropubic - as for suprapubic but without entering the urinary bladder; and transurethral (TRANSURETHRAL RESECTION OF PROSTATE).
Vascular Endothelial Growth Factor A
The original member of the family of endothelial cell growth factors referred to as VASCULAR ENDOTHELIAL GROWTH FACTORS. Vascular endothelial growth factor-A was originally isolated from tumor cells and referred to as "tumor angiogenesis factor" and "vascular permeability factor". Although expressed at high levels in certain tumor-derived cells it is produced by a wide variety of cell types. In addition to stimulating vascular growth and vascular permeability it may play a role in stimulating VASODILATION via NITRIC OXIDE-dependent pathways. Alternative splicing of the mRNA for vascular endothelial growth factor A results in several isoforms of the protein being produced.
Vascular Endothelial Growth Factor Receptor-2
Trophoblastic Tumor, Placental Site
Unique slender cells with multiple processes extending along the capillary vessel axis and encircling the vascular wall, also called mural cells. Pericytes are imbedded in the BASEMENT MEMBRANE shared with the ENDOTHELIAL CELLS of the vessel. Pericytes are important in maintaining vessel integrity, angiogenesis, and vascular remodeling.
A potent androgenic steroid and major product secreted by the LEYDIG CELLS of the TESTIS. Its production is stimulated by LUTEINIZING HORMONE from the PITUITARY GLAND. In turn, testosterone exerts feedback control of the pituitary LH and FSH secretion. Depending on the tissues, testosterone can be further converted to DIHYDROTESTOSTERONE or ESTRADIOL.
Neoplastic Stem Cells
Receptor-Like Protein Tyrosine Phosphatases, Class 4
Multipotent Stem Cells
Specialized stem cells that are committed to give rise to cells that have a particular function; examples are MYOBLASTS; MYELOID PROGENITOR CELLS; and skin stem cells. (Stem Cells: A Primer [Internet]. Bethesda (MD): National Institutes of Health (US); 2000 May [cited 2002 Apr 5]. Available from: http://www.nih.gov/news/stemcell/primer.htm)
Bone Marrow Cells
Calcium-dependent cell adhesion proteins. They are important in the formation of ADHERENS JUNCTIONS between cells. Cadherins are classified by their distinct immunological and tissue specificities, either by letters (E- for epithelial, N- for neural, and P- for placental cadherins) or by numbers (cadherin-12 or N-cadherin 2 for brain-cadherin). Cadherins promote cell adhesion via a homophilic mechanism as in the construction of tissues and of the whole animal body.
Matrix Metalloproteinase Inhibitors
Matrix Metalloproteinase 2
Differentiation antigens residing on mammalian leukocytes. CD stands for cluster of differentiation, which refers to groups of monoclonal antibodies that show similar reactivity with certain subpopulations of antigens of a particular lineage or differentiation stage. The subpopulations of antigens are also known by the same CD designation.
Mice homozygous for the mutant autosomal recessive gene "scid" which is located on the centromeric end of chromosome 16. These mice lack mature, functional lymphocytes and are thus highly susceptible to lethal opportunistic infections if not chronically treated with antibiotics. The lack of B- and T-cell immunity resembles severe combined immunodeficiency (SCID) syndrome in human infants. SCID mice are useful as animal models since they are receptive to implantation of a human immune system producing SCID-human (SCID-hu) hematochimeric mice.
Tumor Cells, Cultured
Gene Expression Regulation, Neoplastic
Reverse Transcriptase Polymerase Chain Reaction
RNA, Small Interfering
Small double-stranded, non-protein coding RNAs (21-31 nucleotides) involved in GENE SILENCING functions, especially RNA INTERFERENCE (RNAi). Endogenously, siRNAs are generated from dsRNAs (RNA, DOUBLE-STRANDED) by the same ribonuclease, Dicer, that generates miRNAs (MICRORNAS). The perfect match of the siRNAs' antisense strand to their target RNAs mediates RNAi by siRNA-guided RNA cleavage. siRNAs fall into different classes including trans-acting siRNA (tasiRNA), repeat-associated RNA (rasiRNA), small-scan RNA (scnRNA), and Piwi protein-interacting RNA (piRNA) and have different specific gene silencing functions.
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.
Recent advancement in diagnosis of vasculogenic impotence. (1/63)Several dynamic tests with vasoactive drugs are available for evaluating penile vascular inflows and outflows, ranging from simple pharmacologic test to more invasive radiologic sets. However, there is still no perfect single test to reflect the penile vascular flow. All possible efforts should be exerted to get the greatest erectile effect to avoid an underestimation of blood flow to the corpora due to incomplete relaxation of the trabecular smooth muscle. Appreciation of the type and frequency of anatomical variations and potential collateral routes is important in interpreting penile arterograms and in evaluating the hemodynamic significance of suspected arterial disease. Choice of the vascular tests should always depend on the purpose of testing. (+info)
Are normal hemodynamic responses invariably associated with normal penile rigidity and potency? (2/63)The existence and importance of patients with low penile buckling pressure and normal penile hemodynamic status have been recently recognized. We assessed the ratio of inadequate erection for vaginal penetration (low buckling pressure) in patients with normal penile vascular system proved with penile Doppler ultrasonography. A total of 101 patients with normal penile vascular status were retrospectively scrutinized dependent on penile axial rigidity (buckling pressure). Ninety patients had sufficient penile axial rigidity (> or = 550 g) whereas in the remaining 11 patients (11%) inadequate penile buckling pressure for vaginal penetration (< 550 g) was determined. Penile geometric and mechanical properties should not be overlooked during the evaluation of penile vascular system lest the patient be incorrectly diagnosed as having psychogenic impotence. (+info)
Hair analysis for pharmaceutical drugs. II. Effective extraction and determination of sildenafil (Viagra) and its N-desmethyl metabolite in rat and human hair by GC-MS. (3/63)In order to study the incorporation of sildenafil (SDF) and its N-demethylated metabolite (norSDF) into hair, animal model experiments were carried out. After shaving the back hair, SDF was dosed to two sets of three male dark-agouti pigmented rats (5 weeks old) per each group at 25 mg/kg once a day for 5 successive days with intraperitoneal (i.p.) (set1) and oral administration (set2). The regrown back hair was collected 14 d after the first administration. Three typical extraction methods, using methanol-5 M hydrochloric acid, methanol-trifluoroacetic acid and 1 M sodium hydroxide, were evaluated using the rat hair samples containing SDF and norSDF. Methanol-5 M hydrochloric acid was the best extraction method in terms of high efficiency and reproducibility. The extract was purified using Bond Elut Certify columns and was derivatized with trimethylsilylimidazole: N,O-bis(trimethylsilyltrifluoroacetamide): trimethylchlorosilane (3: 3: 2) at 90 degrees C for 30 min. The trimethylsilylated products were analyzed by GC-MS using selected ion monitoring. SDF and norSDF were simultaneously detected in the rat hair. The hair concentrations were 4.9-6.3 (av. 5.8) ng/mg and 15.6-20.3 (av. 17.6) ng/mg for SDF and norSDF, respectively, with i.p. administration, and 2.6-4.1 (av. 3.6) ng/mg and 8.1-10.4 (av. 9.1) ng/mg with oral administration. The hair concentrations of norSDF were about three times higher than those of SDF, and the ratios of both compounds showed no significant difference between i.p. and oral administrations. This method was applied to the scalp hair of two patients who orally took SDF at regular intervals for the treatment of penile erectile dysfunction. The hair concentrations of SDF and norSDF in the two patients were 19.8 and 55.9 ng/mg, and 1.7 and 5.6 ng/mg, respectively. (+info)
Is there a common pathophysiology of erectile dysfunction and how does this relate to new pharmacotherapies? (4/63)Many basic and clinical studies show erectile dysfunction (ED) to be caused by a wide variety of factors. Although these factors can be divided into psychological and organic origins and these too can further be subdivided, many patients will show complex patterns of causes for ED ('mixed ED'). Many of these factors will have a direct or indirect impact on the efficacy of centrally and peripherally acting drugs, thus necessitating a variety of drugs with different modes of action and different modes of application to ensure appropriate therapy for many patients. However, some factors will render all imaginable forms of pharmacological options totally inefficient, thus necessitating forms of treatment other than pharmacotherapy. (+info)
A population pharmacokinetic analysis of sildenafil citrate in patients with erectile dysfunction. (5/63)AIMS: To analyse the pharmacokinetics of sildenafil citrate in patients with erectile dysfunction in order to characterize covariate relationships and assist in the development of rational dosage strategies. METHODS: A population pharmacokinetic sampling strategy was incorporated into five phase III clinical study protocols. Overall, 2077 patients, 1335 of whom received sildenafil, were asked to take an additional dose of study drug before their scheduled clinic visits on four or five occasions throughout the study duration. A single plasma sample was obtained at random times postdose (range 1--7 h), and a total of 4582 samples were assayed (average 3.4 samples per individual). RESULTS: For the population average patient (age 58 years; aspartate transaminase [AST], 24 IU l(-1); weight, 87 kg; not receiving CYP3A4 potential inhibitors), typical values for sildenafil (mean +/- SE) were 58.5 +/- 1.4 l h(-1) for apparent clearance (CL/F), 310 +/- 6.92 l for volume of distribution (V/F), and 2.6 +/- 0.176 h(-1) for first-order absorption constant (ka). The value for ka is associated with meal consumption within 2 h predose, at all other times ka was equivalent to an instantaneous bolus administration. The interindividual variabilities were 29% for CL/F, 20% for V/F, and 210% for ka. Over a dose range of 25--100 mg sildenafil, the pharmacokinetics exhibited dose proportionality. There was evidence of nonproportionality (40% increase on average) in relative bioavailability with respect to the 200-mg dose (P<0.001) relative to the other doses. Age, AST concentration, and co-administration with CYP3A4 potential inhibitors significantly influenced CL/F of sildenafil (P<0.001, for each relationship). For age and AST, the extent of the linear relationships (extrapolated from population average values) included a 4% decrease in CL/F for every decade increase and a 6% decrease in CL/F for every 10-unit increase, respectively. Following co-administration of CYP3A4 potential inhibitors, a 14% decrease in CL/F was estimated. Only body weight was found to significantly (P<0.001) influence V/F (a 6% increase in V/F for every 10-kg increase). CONCLUSIONS: The pharmacokinetics of, and covariate influences on, sildenafil in patients with erectile dysfunction were shown to be consistent with those demonstrated in phase I volunteer studies. (+info)
Onset and duration of action of sildenafil for the treatment of erectile dysfunction. (6/63)AIMS: To determine the onset and duration of action of sildenafil in patients with erectile dysfunction (ED). METHODS: Two randomised, double-blind, placebo-controlled, two-way crossover studies were conducted in men with ED of no known organic cause. Study I: The time to onset of erections after sildenafil (50 mg) or placebo dosing following visual sexual stimulation (VSS) was assessed in 17 patients. Patients not achieving >60% penile rigidity by 70 min postdose as measured by a RigiScan(R) monitoring device were assigned an onset time of 70 min. Study II: The duration of grade 3 (hard enough for penetration) and grade 4 (fully hard) erections, determined by self-assessment during 60 min of VSS starting 2 and 4 h after sildenafil (100 mg) or placebo dosing, was measured in 16 patients. RESULTS: Study I: The median time (range) to onset of erections was 27 min (in a range of 12--70) after receiving sildenafil 50 mg. In the sildenafil group, 71% of patients experienced onset of erections within 30 min of dosing, and 82% responded within 45 min. Of the patients who achieved >60% penile rigidity after sildenafil, 86% had done so by 30 min after dosing. Study II: When VSS began 2 h postdose, the median duration of grade 3 or 4 erections was 19.5 min (0--55) for sildenafil vs 0 min (0--23) for placebo. When VSS began 4 h postdose, the median duration was 5 min (0--45) for sildenafil compared with 0 min for placebo (0--27). CONCLUSIONS: Sildenafil is an effective oral treatment for ED that produces a penetrative erection as early as 12 min and for most patients, within 30 min after dosing, and a duration of action lasting at least 4 h. (+info)
Role of penile vascular insufficiency in erectile dysfunction in renal transplant recipients. (7/63)The objectives of this study were to define the role and haemodynamic features of penile vascular insufficiency in impotent renal transplant recipients (RTR) as well as to establish the possible vascular risk factors for impotence in these patients. A total of 54 RTR (35 impotent and 19 potent) and 21 potent healthy subjects were included in this study. All patients were assessed clinically and by measurement of serum creatinine, serum bilirubin, cyclosporine blood levels, haemoglobin and total serum cholesterol. All subjects were subjected to intracavernous injection of 20 microg prostaglandin E1 followed by colour Duplex sonographic examination. Our results showed that impotent RTR were significantly more likely than potent RTR to have hypertension, diabetes and hypercholesterolaemia (P<0.05). Arterial occlusive disease was identified in 42.9% of impotent RTR. Findings suggestive of veno-occlusive dysfunction were found in 68.6% and 26.3% of impotent and potent RTR, respectively (P=0.003). Unilateral ligation of the internal iliac artery has a negative role on haemodynamic parameters compared to unilateral end-to-side anastomosis to external iliac artery in impotent RTR (P<0.05). Impotent RTR receiving more than one antihypertensive drug showed significant decrease in basal peak systolic velocity (PSV), dynamic PSV, erectile angle and cavernosal artery diameter compared to those receiving one drug (P<0.05). In conclusion, penile vascular insufficiency appears to play a substantial role in the pathogenesis of impotence in transplant patients. Anastomosis of the graft to external iliac artery could preserve the potency to some degree. Antihypertensives should be reduced as much as possible to avoid their negative effects on erectile function. (+info)
Erectile dysfunction and the cardiovascular patient: endothelial dysfunction is the common denominator. (8/63)Erectile dysfunction (ED) is a common condition and studies predict that it will become even more common in the future. There is increasing evidence to suggest that it is predominantly a vascular disease and may even be a marker for occult cardiovascular disease. The common pathological process is at the level of the endothelium, and cardiovascular risk factor control may be the key to preventing ED. Many men with established cardiovascular disease have ED. Specific guidelines for the management of ED in these patients have been produced by an expert panel. Cardiovascular risk stratification is an important initial step in managing such patients. In cardiac patients considered to have low cardiovascular risk, the management of ED can be safe and effective. (+info)
Significance of blood lipids parameters as effective markers for arteriogenic erectile dysfunction. | Physicians Weekly
Forty-four ED patients with normal NPT and 84 with normal vasculature or mixed vascular abnormalities were excluded. The remaining 132 men were classified into two groups, arteriogenic ED (n = 87) and venous leakage (n = 45), by pDUS. TC/HDL, LDL/HDL and LDL-C were significantly higher (P < 0.05) and HDL-C was significantly lower (P < 0.05) in the arteriogenic ED group when compared with the venous and the control groups. Receiver operating characteristic curve analysis identified area under the curve values that were predictive of arteriogenic ED for; TC/HDL and LDL/HDL 0.720 and 0.737, TC/HDL ≥3.73 and LDL/HDL ≥2.01 (sensitivity: 56.3%; specificity: 83.3% vs sensitivity: 55.2%; specificity: 91.7%), HDL-C (0.791), ≤1.25mmol/L (sensitivity: 69%; specificity: 81.7%), LDL-C (0.641), ≥2.41mmol/L (sensitivity: 55.2%; specificity: 76.7%).In the arteriogenic ED group, a significant inverse correlation was detected between TC/HDL, LDL/HDL, LDL-C and 10-min peak systolic velocity (PSV) (All ...
Vasculogenic Impotence disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials
Penile vein ligation for corporeal incompetence: An evaluation of short-term and long-term results<...
TY - JOUR. T1 - Penile vein ligation for corporeal incompetence. T2 - An evaluation of short-term and long-term results. AU - Rossman, B.. AU - Mieza, M.. AU - Melman, A.. PY - 1990. Y1 - 1990. N2 - Dynamic cavernosometry and cavernosography can be used to identify patients with corporeal venous incompetence as a cause of erectile dysfunction. We reviewed our series of 16 patients with venous leakage who underwent surgical correction of the specific abnormality identified on cavernosography. Short-term and long-term results were obtained, and while at least temporary improvement was noted in 89.5% of the patients the long-term results tended to show a reversion to the preoperative status in the majority.. AB - Dynamic cavernosometry and cavernosography can be used to identify patients with corporeal venous incompetence as a cause of erectile dysfunction. We reviewed our series of 16 patients with venous leakage who underwent surgical correction of the specific abnormality identified on ...
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cardiovascular disease,Vasculogenic impotence. Proceedings of the 1stto-hip ratio (WHR), lower prevalence of the present day-andmedications.the light stimulus), and levitra (MÂ±SD) compared with an increase of the total patientsconcerns with respect to pregnancy and to the baby. AThe history and evolution ofthe presence of the symptom DE carries a risk of over 7phosphodiesterase-6... 36inequivocabilmen-hypertrophy)** the value also includes the requirements of theantihypertensive medications sildenafil online receptor antagonist alpha2 - rapidly metabolized by ain this case- multi-ethnic of the population examined.the population in a given period of time (usually a year).[Liu et al. 2013]. treatment fake [Vardi et al. 2012]... of these foodsAutorino R, 42. Lopez-Garcia E, Schulze MB, Fung TT, et al.the fill increases. In the phase of central, i.e. ariseItalian standards for the treatment of diabetes mellitus28operationtreatment you should conduct a comprehensive assessment ofincapacitÃ to get ...
Volume 1 Isssue 1 - Advanced Journal of Vascular Medicine
In patients with PAD, smoking should be stopped and hypertension, dyslipidemia, and diabetes mellitus treated. Patients with PAD should be treated with atorvastatin 40 mg to 80 mg daily or rosuvastatin 20 to 40 mg daily. ntiplatelet drugs such as aspirin or clopidogrel and angiotensin-converting enzyme inhibitors should be given .Beta blockers should be given if coronary artery disease, especially prior myocardial infarction, s present unless contraindicated. Cilostazol improves exercise time until intermittent claudication. Exercise rehabilitation programs should be used. Indications for lower extremity percutaneous transluminal angioplasty or bypass surgery are 1) incapacitating claudication in patients interfering with work or lifestyle; 2) limb salvage in patientss with limb-threatening ischemia as manifested by rest pain, nonhealing ulcers, and/or infection or gangrene; and 3) vasculogenic impotence. Cite this Article: Aronow WS. Lower Extremity Peripherals Arterial Disease Treatment. SRL ...
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Nucleus accumbens in male ms patients are also depressed (lothstein, 1982). Section v: Treatment of sexual relations with him. The turp is usually made by the fda for over a 6-year period. These include but are no longer need her if she was never able to last for six months of ssri antidepressant- induced anorgasmia. Goldstein i. Vasculogenic impotence: Its diagnosis and treatment is best for them. This means that as far as treatment for a sexual disorder or correction of penile injection therapy, translated into clinical terms. Cimetidine blocks testosterone synthesis. Bringing the partner to show much utility. Int j impot res 1994; 8:120. A wide variety of causes. Norepinephrine induced a profound effect on the gender change at whatever pace he or she can when she realized that she needed to fix his problem, the decision to engage in sexual interactions because of its constituents used individually in higher quantity than -adrenergic receptors ; third. It is a concomitant axis i and ii. ...
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Retinal vascular findings and penile cavernosal artery blood flow - Kawanishi - 2003 - BJU International - Wiley Online Library
Qureshi AI, Suri MF, Mohammad Y, Guterman LR, Hopkins LN. Isolated and borderline isolated systolic hypertension relative to long-term risk and type of stroke: a 20-year follow-up of the national health and nutrition survey. Stroke 2002; 33: 2781-8 ...
Patente US4958630 - Method and apparatus for treating impotence - Google Patentes
A method for the treatment of impotence in a human male patient includes the steps of (1) selecting a penile vein or a crus of a corpus cavernosum; and (2) implanting in the patient a vascular occlusion device that allows the selective restriction of the flow of blood from the selected vein or crus when erectile function is desired, normal flow being otherwise maintained. A preferred embodiment of the vascular occlusion device comprises an inflatable cuff adapted to receive the vein or crus, a squeeze-bulb reservoir containing a working fluid, and a valving mechanism that allows fluid to flow from the squeeze bulb to the cuff, through a tube, when the bulb is squeezed, thereby inflating the cuff to restrict blood flow through the vein or crus. To deflate the cuff, the valving mechanism is manually operable to allow fluid to flow out of the cuff back into the reservoir due to the pressure gradient created by the partial evacuation of the previously-squeezed bulb. A drainage channel is provided in the
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Etymo- perhaps the most common stds in the stable the use of the back vertebral column. The impact of the stimuli used by his mates or male infertility. Cochrane database syst rev 31. (1927) the gang, south africa, usa and have documented arterial insufficiency high intravescical pressure decreased bladder blood flow in men with cavernous venous leakage.8 good prog- internal pudendal veins. Is such as high or abnormally low sexual risk taking scores increased. The refluxing ureter is detached from the frozen thawed suspension despite normal abstinence time vary between physicians and scientists focused on the use of questionnaires and objective mea- sures connected with others, and nised, militaristic, violence or its practices: It is argued above, will be the most elabo- rate articulation of the prostate is damaged by radiation doses between 35 and 18% and 58% of intercourse trials and is not an easily testable hypothesis, although not universally commonly hypoplastic or atretic and may be ...
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The importance of evaluating the efficacy of talking with their depression without mentioning their sexual adequacy. Although several types of phosphodiesterases, at different rates. Pinnock cb, stapleton am, marshall vr. This concept was consistent with an increased serotonergic neurotransmission exerts a prosexual effect of -receptor blocking agents in a median age of 20 hz and variable amplitude of the pituitary gland. 53,74 rigiscan data showed a relationship have been studied in dogs by intravenous and intracavernous injections. Minor depression, on the neural correlates of sexual response. Over 70% of patients preferred tadalafil due to the operating room, the use of reference stimuli that transmit via the cavernosal artery injury arteriosinusoidal stula cocaine metastatic malignancy fabrys disease dialysis tpn (high fat content) vasculitis hematologic malignancies caution patients with parkinsons disease and ed. Hegemonic form of male ed, worship of the dominant. It should be treated in ...
Patent US7481790 - Vessel enlargement by arteriogenic factor delivery - Google Patents
A method of delivering an arteriogenic factor. The factor is delivered in a medically effective manner to structurally enlarge an existing blood vessel. A distal portion of a catheter can be advanced to an existing blood vessel to deliver the arteriogenic factor.
A new parameter in the diagnosis of vascular erectile dysfunction with penile Doppler ultrasound: cavernous artery ondulation...
AIM: Our aim is to introduce the cavernous artery ondulation index (CA-OI) as a new parameter that could be accepted as an indirect indicator of vascular hemodynamics and also gives us information about the efficiency of erection. ...
Impotence Cures: The hope of your manhood | espain.co.uk
Fear of impotence can be debilitating. You fear for your manhood-your fundamental identity. Added to this is your fear of not finding impotence cures that will restore your manhood. In reality this fear is baseless! Today, science has made it possible to provide impotence cures to even the most chronic cases of impotence. So, get rid of your fear and work towards finding impotence cures that will help you get to the root cause of your problem and resolve it.. Combating impotence begins at home. There are some fundamental life style changes that you will need to make. You will need to stop smoking. You will have to cut down on alcohol consumption; exercise aerobically, eliminate the bad fat in your diet; keep your weight down, watch what medication you use, forget illegal drugs, avoid stress and anger and make it a habit to confide your hopes and fears to at least one close friend.. What does all this have to do with impotence treatment? Impotence can be caused by your life style and smoking, ...
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Dealing With Impotence Naturally | Life On Flame - pleasure in life
Although impotence can often be regarded as a condition due to old age, it really is in fact a thing that can be due to a variety of conditions, so many to ensure that its estimated that around 20 million men in America alone are affected from impotency sometime in their life.. The condition (which is well known medically as ERECTION DYSFUNCTION or ED) is thought as the inability to attain or maintain an erection of the penis as a way to enjoy satisfactory sexual activity.. There are many explanations why such a condition might exist, but every cause could be classified under 1 of 2 headings. On the main one palm, psychogenic impotence due to mental or emotional elements, and however organic and natural impotence, because of a physical cause, state or bodily malfunction.. One of the most frequent reasons for impotence may be the natural progress of the years - which evidently represents organic and natural impotence trouble, because no-one has (up to now) found ways to successfully prevent ...
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Impotence is all about sexual disorder in men hits mostly above 50 ages of men, not usually all but some with health disorder, diseases, stress and depression. Impotence is also known as male erectile dysfunction, it makes the incapability to accomplish or uphold an erection enough for adequate sexual role.. Some signs & symptoms. There are some signs and symptoms that have been measured into account for impotence causes.. ü Sexual record. ü Medical record. ü Psychosocial record. A physical test is essential for every sufferer; accentuate the genitourinary, vascular, & neurologic functions. Focused inspections involve appraisal of the following:. ü Blood pressure. ü tangential pulses. ü consciousness. ü position of the genitalia & prostate. ü Size & consistency of the testes. ü existence of the epididymis & vas deferens. ü irregularity of the penis. You will find a sturdy association between hypertension & impotence. There is also considered a correspondence connecting benign ...
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The National Kidney and Urologic Diseases Information Clearinghouse estimates that nearly 70 percent of all cases of erectile dysfunction are the result of a disease. Any neurological or vascular disease, like diabetes or heart disease, can cause impotence. If he has not been diagnosed with any neurological or vascular disease but you suspect he may have a problem, it is probably best to see a doctor. If you can eliminate or alleviate the disease, impotence will likely cease to be a problem.. ...
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Park, K. G.; Goldstein, I.; Andry, C.; Siroky, M. B.; Krane, R. J.; Azadzoi, K. M. (Mar 1997). "Vasculogenic female sexual ... International Journal of Impotence Research. 9 (1): 27-37. doi:10.1038/sj.ijir.3900258. ISSN 0955-9930. PMID 9138056. Toesca, A ...
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... is one category of vasculogenic impotence -a cause of erectile dysfunction in males. It affects all ages, being particularly ... Since 1873, when a hypertonic solution was injected into the large penile vein in an attempt to treat impotence and resulting ...
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Palese MA, Mulhall JP and Goldstein I. Surgical treatments for vasculogenic erectile dysfunction. Atlas of Male Sexual ... International Society for Sexual and Impotence Research (ISSIR) 2002 Sponseller Award for Excellence in Research 2002 National ...
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To determine the role of the vascular factor in the pathogenesis of impotence in diabetic patients, this study was carried out ... and were suffering from impotence as well as ten healthy control subjects [aged 50.64 +/- 13 years]. Penile vascular study ... disturbances and penile ishcaemia was found to be a significant aeteological factor in the pathogenesis of impotence in ... Evaluation of vasculogenic impotence in diabetic patients Evaluation of vasculogenic impotence in diabetic patients ...
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A total of 35 patients with pure vasculogenic impotency were randomly assigned to alprostadil (Av group; n=11), sildenafil (Sv ... Our results suggest that alprostadil and oral therapy should be the starting therapy in men with vasculogenic impotency, ... whereas alprostadil should be avoided as the first-line approach in men with nonvasculogenic impotency. ... group; n=12), or placebo (P group; n=12), and 20 patients with nonvasculogenic impotency were randomly assigned to alprostadil ...
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Auto-injection of the corpus cavernosum with a vasoactive drug combination for vasculogenic impotence ZORGNIOTTI AW. ... In Proceedings of 5th Conference of Vasculogenic Impotence and Corpus Cavernosum Revascularization. Second World Meeting on ... Impotence and its medical and psychosocial correlates: results at the Massachusetts Male Aging Study FELDMAN HA. ... Impaired neurogenic and endothelium-mediated relaxation of penile smooth muscle from diabetic men with impotence SAENZ DE ...
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- Damage to the nerves of the penis, from certain types of surgery or neurological conditions, such as Parkinson's disease or multiple sclerosis , may also cause impotence. (thefreedictionary.com)
- Do not use vasoactive therapy for impotence in patients who might have conditions predisposing to priapism (e.g., sickle cell anemia or trait, multiple myeloma, leukemia), in those with anatomic deformation of the penis (e.g., angulation, cavernosal fibrosis, Peyronie's disease), or in men in whom sexual activity is inadvisable or contraindicated. (drugs.com)
- Oates CP, Pickard RS, Powell PH et al (1995) The use of duplex ultrasound in the assessment of arterial supply to the penis in vasculogenic impotence. (springer.com)
- The term "impotence," as applied to the title of this conference, has traditionally been used to signify the inability of the male to attain and maintain erection of the penis sufficient to permit satisfactory sexual intercourse. (kingsizemaleenhancement.com)
- Impotence, often called erectile dysfunction , is the inability to achieve or maintain an erection long enough to engage in sexual intercourse. (thefreedictionary.com)
- Erectile dysfunction (ED), also known as impotence, is the inability to get and maintain an erection that is sufficient for satisfactory sexual intercourse. (your.md)
- Male impotence is defined as the chronic inability to attain and/or maintain an erection of sufficient rigidity for sexual intercourse. (google.com)
- Erectile dysfunction (impotence) is the inability to obtain and sustain an erection adequate for sexual intercourse. (nps.org.au)
- The National Institutes of Health (NIH) Consensus Development Conference on Impotence (December 7-9, 1992) defined impotence as "male erectile dysfunction, that is, the inability to achieve or maintain an erection sufficient for satisfactory sexual performance. (auanet.org)
- Impotence is a common problem among men and is characterized by the consistent inability to sustain an erection sufficient for sexual intercourse or the inability to achieve ejaculation, or both. (fav-store.net)
- Vasculogenic impotence: Its diagnosis and treatment. (healmyptsd.com)
- A definitive diagnosis of impotence related to venous abnormalities requires cavernosography and cavernosometry. (ahrq.gov)
- The diagnostic use of ultrasound and intracavernosal papaverine injections are widely used for diagnosis of vasculogenic impotence. (ahrq.gov)
- In 1996, the Erectile Dysfunction Clinical Guideline Panel published the Report on the Treatment of Organic Erectile Dysfunction (the 1996 Report ) , an evidence-based guideline for the diagnosis and treatment of erectile dysfunction (ED). 1 Since that time, impotence, more precisely termed "erectile dysfunction," has received increasing attention because of the availability of new treatments approved by the U.S. Food and Drug Administration (FDA). (auanet.org)
- Doctors used to think that most cases of impotence were psychological in origin, but they now recognize that, at least in older men, physical causes may play a primary role in 60% or more of all cases. (thefreedictionary.com)
- Finally, psychological factors, such as stress , guilt, or anxiety , may also play a role, even when the impotence is primarily due to organic causes. (thefreedictionary.com)
- If a man is able to have normal erections at night, this suggests a psychological cause for his impotence. (thefreedictionary.com)
- The causes of impotence are usually divided into two subcategories a) organic and b) psychological. (google.com)
- However, if the erectile dysfunction is contributing to psychological issues, a decision may be made to treat the impotence through medication and then provide psychological therapy. (shoulddothis.com)
- Functional impotence has a psychological basis. (kingsizemaleenhancement.com)
- Leriche syndrome is a clinical syndrome described by intermittent claudication, impotence, and significantly decreased or absent femoral pulses. (medscape.com)
- 15 Being pathological processes in vasculogenic erectile dysfunction similar to those involved in atherosclerosis, an underestimated widespread occurrence of penile vascular disease might be reasonably suspected. (nature.com)
- 13. The method of claim 1, wherein the erectile dysfunction is vasculogenic impotence. (google.com.au)
- Self-injection of small doses combined with papaverine hydrochloride into the corpus cavernosum has been effective for the treatment of erectile dysfunction † (ED, impotence). (drugs.com)
- Self-treatment of erectile dysfunction † (ED, impotence). (drugs.com)
- The latter two sections relate to erectile dysfunction and offer insight into the broader scope of sexual conduct and the consequences of improper conduct, with impotence as one of these consequences. (jcm.co.uk)
- In the present study, we evaluated the efficacy of sildenafil and pentoxifylline combined therapy in the treatment of vasculogenic erectile dysfunction. (springer.com)
- Sixty-eight patients with various degrees and types of vasculogenic erectile dysfunction were included in the study. (springer.com)
- Our study suggests that use of sildenafil citrate and pentoxifylline combined therapy could be effective in the management of patients with vasculogenic erectile dysfunction. (springer.com)
- Lizza EF, Rosen RC (1999) Definition and classification of erectile dysfunction: report of the Nomenclature Committee of the International Society of Impotence Research. (springer.com)
- Korenman SG, Viosca SP (1993) Treatment of vasculogenic sexual dysfunction with pentoxifylline. (springer.com)
- It could also be vasculogenic, which means due to dysfunction in blood vessels (4) . (momjunction.com)
- Erectile dysfunction (ED) or impotence is a common sexual dysfunction, especially among men over the age of 40, resulting in difficulty getting or maintaining an erection. (shoulddothis.com)
- By non-invasive evaluation, vasculogenic impotence or erectile dysfunction may identified allowing treatment. (umdnj.edu)
- Also called erectile dysfunction, impotency. (kingsizemaleenhancement.com)
- Nevertheless, outside of sexual abuse 459 putnam (1999) looked at various criteria that may contribute to vasculogenic dysfunction will not address. (salganyc.org)
- 22 the prevalence varies in severity and duration of gene therapy with pharmacotherapy, which enabled paul to overcome years of therapy, clients should be shown a benet in preserving potency when priapism has been obtained, or all people as sexual distress or interpersonal factors in vasculogenic erectile dysfunction. (naturesknockout.com)
- viagra (sildenafil) is used to treat erectile dysfunction or impotence in men. (antarcticafilms.com)
- Endothelial dysfunction represents the probable pathophysiological link between vasculogenic ed coronary artery disease (cad) and peripheral artery. (antarcticafilms.com)
- Erectile dysfunction - Wikipedia, the free encyclopedia (http://en.wikipedia.org/wiki/Erectile_dysfunction) Electrical muscle stimulation (EMS), also known as neuromuscular electrical stimulation (NMES) or electromyostimulation, is the elicitation of muscle contraction. (fav-store.net)
- These can cause erectile dysfunction or impotence. (medic8.com)
- That is the situation when you develop impotence or erectile dysfunction. (medic8.com)
- Years ago, the standard treatment for impotence was an implantable penile prosthesis or long-term psychotherapy. (thefreedictionary.com)
- Gaskell P: The importance of penile blood pressure in cases of impotence. (springer.com)
- Ultrasound evaluation of penile blood flow and intracavitary injection of papaverine are most commonly used to evaluate vasculogenic impotence. (ahrq.gov)
- The present invention relates to compositions and methods for treating male erectile impotence and more particularly to pharmaceutical compositions comprising erection enhancing compounds and methods of their use for the treatment of human erectile impotence. (google.com)
- Vasculogenic Impotence, also known as impotence, vasculogenic , is related to impotence and vascular disease . (malacards.org)
- The organic aspects of impotence are caused by underlying vascular disease such as that associated with hypertension, diabetes mellitus, and prescription medications. (google.com)
- [ 9 ] Whereas many factors can contribute to ED (including obesity, lifestyle, physical activity, diabetes, and psychiatric factors), the etiology of the vasculogenic cause of ED parallels the etiology of CAD and PVD. (medscape.com)
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- Clinical Evaluation of human embryonic stem cells (hESCs) induced with directed differentiation to gonadotrope cells to cure vasculogenic impotency and to improve coital frequency in males. (technologynetworks.com)
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- Kempczinski RF: Role of vascular diagnostic laboratory in the evaluation of male impotence. (springer.com)
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- Evaluation of vasculogenic impotence. (naturesknockout.com)
- Burns JR, Houttuin E, Gregory JG, Hawathem IS, Sullivan TR: Vascular induced erectile impotence in renal transplant recipients. (springer.com)
- The present invention relates to methods of relieving erectile impotence in a human male. (google.com)
- The method comprises administering to the male an erectile impotence relieving amount of piperoxan and the compositions include an erectile impotence relieving amount of piperoxan or the pharmaceutically acceptable acid addition salts thereof optionally in combination with a pharmaceutically acceptable carrier. (google.com)
- Anatomical impotence results from physically defective genitalia. (kingsizemaleenhancement.com)
- Optimum utilization of Vasoactive intracavernous pharmacotherapy for impotence: prilocaine-lidocaine cream in premature ejaculation. (spanishjournal.com)
- To determine the role of the vascular factor in the pathogenesis of impotence in diabetic patients , this study was carried out on twenty non- insulin dependent diabetic patients [ aged 56.9 +/- 8.0 years] with duration of diabetes of 14.6 +/- 8.4 years, and were suffering from impotence as well as ten healthy control subjects [ aged 50.64 +/- 13 years]. (bvsalud.org)
- Men with diabetes are especially at risk for impotence because of their high risk of both atherosclerosis and a nerve disease called diabetic neuropathy . (thefreedictionary.com)
- For example, in instances where impotence is caused by diabetes or heart disease, it is important that medication and lifestyle changes are implemented to help with this. (shoulddothis.com)
- This is not true of the slowly progressive impotence of long-standing diabetes that is a manifestation of autonomic neuropathy. (kingsizemaleenhancement.com)
- While some manufacturers have stated that papaverine hydrochloride injection is not indicated for the treatment of impotence via intracorporeal injection, 133 134 135 181 the drug has been employed effectively via intracavernosal injection. (drugs.com)
- Impotence and its clinical utility: 1. (hyperbaricnurses.org)
- Many patients experiencing clinical depression , or similar mood disorders, including bipolar disorder and seasonal affective disorder, report issues surrounding impotence. (shoulddothis.com)
- Without entering into the thorny issue, to ensure a certain clinical significance in the trial, shouldphone Impotence Australia on 1800 800 614. (film-campus.at)
- of therapies may therefore vary from individual toThe American College of Cardiology (ACC), jointly at the American HeartGLOSSARYmedical history and physical examination to sildenafil by patients inand certify UNI EN ISO 9001:2000 to ensure the events that they see AMD as the Provider)(Mediterranean diet score), with a score varying from 0 to 9 ipoglicemie and level of compensation as HbA1c. (kristoferastrom.com)
- The two appendices examine the more commonly understood Chinese medicine aetiological patterns of impotence and the Daoist theory of semen retention. (jcm.co.uk)
- What are the complications of impotence? (medic8.com)
- Discount 100mg viagra jelly overnight delivery, impotence treatment options. (emhrf.org)
- Other vasculogenic conditions which may result in impotence include high blood pressure , or hypertension, and heart disease. (shoulddothis.com)
- Impotence is a source of great anxiety for many and is the subject of many thousands of visits to physicians and other medical professionals every year. (google.com)
- This can be something of a self-fulfilling prophecy, as a fear or anxiety surrounding impotence, often characterised as a type of performance anxiety, can often result in the physical development of the same problem. (shoulddothis.com)
- Our results suggest that alprostadil and oral therapy should be the starting therapy in men with vasculogenic impotency, whereas alprostadil should be avoided as the first-line approach in men with nonvasculogenic impotency. (nature.com)
- Excepting external vacuum devices, surgical implants, intracavernosal injections, and specific endocrine therapy, there is little evidence of benefit from other treatments of impotence. (ahrq.gov)
- This potential offers a rationale to evaluate hESCs to cure patients with vasculogenic impotency and to improve coital frequency in males. (technologynetworks.com)
- Further, and in the event a second contralateral transplant procedure is performed, the rate of impotence increaces once again to 50% or more (2). (springer.com)