A condition that is caused by HYPERPLASIA of LYMPHOCYTES in the small intestine (INTESTINE, SMALL) and the mesenteric LYMPH NODES. These lymphocytes produce an anomalous alpha heavy chain protein. Generally, these IPSID patients have either concurrent LYMPHOMA or develop lymphoma within a few years. The disease was first described in the Mediterranean region and is characterized by malabsorption; WEIGHT LOSS; DIARRHEA; and STEATORRHEA.
The class of heavy chains found in IMMUNOGLOBULIN A. They have a molecular weight of approximately 58 kDa and contain about 470 amino acid residues arranged in four domains and an oligosaccharide component bound covalently to their Fc fragment constant region.
Disorders characterized by abnormal proliferation of primary cells of the immune system or by excessive production of immunoglobulins.
General term for a group of MALNUTRITION syndromes caused by failure of normal INTESTINAL ABSORPTION of nutrients.
The portion of the GASTROINTESTINAL TRACT between the PYLORUS of the STOMACH and the ILEOCECAL VALVE of the LARGE INTESTINE. It is divisible into three portions: the DUODENUM, the JEJUNUM, and the ILEUM.
Pathological processes in any segment of the INTESTINE from DUODENUM to RECTUM.
An angiocentric and angiodestructive lymphoproliferative disorder primarily involving the lungs. It is caused by an Epstein-Barr virus-induced transformation of the B-cells, in a T-cell rich environment. Clinically and pathologically it resembles EXTRANODAL NK-T-CELL LYMPHOMA.
Inflammation of a DIVERTICULUM or diverticula.
Tumors or cancer of the INTESTINES.

Nodular glomerulosclerosis with deposition of monoclonal immunoglobulin heavy chains lacking C(H)1. (1/9)

The objective of this study was to further characterize the clinical and immunopathologic features of heavy chain deposition disease (HCDD), a recently described entity. Four patients were diagnosed as having HCDD on a kidney biopsy. All presented with nodular glomerulosclerosis with deposition of gamma1 heavy chains lacking CH1 epitopes, but without light chains. Two different patterns were observed in the serum. First, patients 1 and 2 had a circulating monoclonal IgGlambda containing a short gamma1 heavy chain lacking CH1 epitopes, with an apparent molecular weight of 40 kD consistent with a complete CH1 deletion. Biosynthetic experiments also showed that the deleted heavy chain was produced in excess compared with light chains, and was secreted in vitro together with half Ig molecules, although these abnormal components were not detected by Western blot analysis of whole serum. Second, patients 3 and 4 had a circulating monoclonal IgG1lambda with an apparently normal, nondeleted heavy chain subunit, but serum fractionation followed by immunoblotting revealed an isolated monoclonal gamma1 chain lacking CH1 epitopes. These data strongly suggest that renal deposition of a CH1-deleted heavy chain circulating in low amounts in the serum as a free unassembled subunit is a major feature of HCDD. The CH1 deletion is most likely responsible for the premature secretion in blood of the heavy chain by a clone of plasma cells.  (+info)

Immunoproliferative small intestinal disease associated with Campylobacter jejuni. (2/9)

BACKGROUND: Immunoproliferative small intestinal disease (also known as alpha chain disease) is a form of lymphoma that arises in small intestinal mucosa-associated lymphoid tissue (MALT) and is associated with the expression of a monotypic truncated immunoglobulin alpha heavy chain without an associated light chain. Early-stage disease responds to antibiotics, suggesting a bacterial origin. We attempted to identify a causative agent. METHODS: We performed polymerase chain reaction (PCR), DNA sequencing, fluorescence in situ hybridization, and immunohistochemical studies on intestinal-biopsy specimens from a series of patients with immunoproliferative small intestinal disease. RESULTS: Analysis of frozen intestinal tissue obtained from an index patient with immunoproliferative small intestinal disease who had a dramatic response to antibiotics revealed the presence of Campylobacter jejuni. A follow-up retrospective analysis of archival intestinal-biopsy specimens disclosed campylobacter species in four of six additional patients with immunoproliferative small intestinal disease. CONCLUSIONS: These results indicate that campylobacter and immunoproliferative small intestinal disease are associated and that C. jejuni should be added to the growing list of human pathogens responsible for immunoproliferative states.  (+info)

Roles of syndecan-1, bcl6 and p53 in diagnosis and prognostication of immunoproliferative small intestinal disease. (3/9)

AIM: To evaluate roles of syndecan-1, bcl6 and p53 in diagnosis and prognostication of immunoproliferative small intestinal disease (IPSID) and to study profiles of kappa (kappa) and lambda (lambda) light chains and IgA heavy chain. METHODS: The study consisted of 11 cases of IPSID and similar number of controls which included 11 of normal intestinal mucosa and 11 of high grade B cell lymphoma of ileum. The parameters analyzed included clinical profiles, biochemical and other laboratory investigations, radiologic and histological findings including immunohistochemistry. RESULTS: All IPSID cases had demonstrable serum IgA heavy chain and heavy mucosal plasma cell infiltration. According to Galian's histological staging, there were 4 patients with stage A and 7 with stage B. kappa and lambda light chains were over-expressed in 7 patients; 1 stage A patient had H pylori-positive active gastritis and eradication of H pylori led to disease remission. Stage A biopsies had higher expression for syndecan-1, while stage B had higher expression for bcl6 and p53. Syndecan-1, kappa and lambda light chains and IgA heavy chain showed inverse relationship with bcl6 and p53. All patients were treated with doxycycline. CHOP regime was added in 5 patients who developed frank lymphoma. Three died of the disease due to extensive organ infiltration. CONCLUSION: Certain immunomarkers like syndecan-1, kappa and lambda light chains and IgA heavy chain could be of much help in identifying early stage IPSID. Stage B IPSID showed higher expression for bcl6 and p53 than stage A IPSID. bcl6 and p53 expressions correlated with a more advanced disease stage and aggressive tumour behavior.  (+info)

Immunoproliferative small intestinal disease with protein loss complicated with duodenal T cell lymphoma during progression. (4/9)

A 52-year-old man was admitted to our hospital in October 2001 with abdominal pain. Abdominal X-ray indicated a diagnosis of ileus. Histopathological and immunological examination resulted in a diagnosis of immunoproliferative small intestinal disease (IPSID). He was treated with THP-COP therapy (pirarubicin, cyclophosphamide, vincristine, and prednisolone), which resulted in complete remission. Outpatient follow-up revealed hypoalbuminemia in May 2003 and upper gastrointestinal endoscopy showed duodenal mucosal nodularity. He was diagnosed with relapsed IPSID and salvage chemotherapy was started. Follow-up endoscopy confirmed that the therapy was effective, but uncovered another duodenal mucosal nodularity. Immunohistochemical staining revealed T-cell lymphoma. Chemotherapy was discontinued and the patient died in December 2004.  (+info)

Immunoproliferative small intestinal disease versus colonic monoblastic sarcoma in a 2-year-old boy. (5/9)

The authors present a case of colonic monoblastic sarcoma, previously treated for other digestive abnormalities (malabsorbtion, Hirschprung's disease). Important similitudes with immunoproliferative small intestinal disease (IPSID) lymphoma were demonstrated for this patient (male, 2-year-old). His main admission complaints were failure to thrive, recurrent episodes of enterocolitis and malabsorbtion syndrome. Some particularities of this case are the young age and the extremely rapid development of the malignant disease in a patient with no previous signs of acute non-lymphoblastic leukemia. The initial diagnosis was of malabsorbtion syndrome, based on the clinical exam at presentation, and then the patient was thought to have a form of Hirschprung's disease, due to a functional intestinal disorder (slow transit). After the necropsy, pathologists diagnosed an immunoproliferative small intestinal disease, and four years later, they performed a more appropriate pathological exam, which explained better clinical symptoms associated to this complex case.  (+info)

Immunoglobulin gene rearrangement in immunoproliferative small intestinal disease (IPSID). (6/9)

Analysis of DNA from the mucosal tissue of three patients with immunoproliferative small intestinal disease (IPSID) and alpha chain disease, two of whom had early stage disease responsive to antibiotics, showed monoclonal heavy and light chain gene rearrangements in all cases. These findings suggest that IPSID is neoplastic even in its early stages, but that the neoplastic cells respond to normal stimuli. Monoclonal lymphoid populations could not be detected in circulating lymphocytes from these patients, which raises the possibility that the circulatory pathways of lymphocytes derived from human gut associated lymphoid tissue may not necessarily parallel those in experimental animals.  (+info)

Non-secretory alpha chain disease involving stomach, small intestine and colon. (7/9)

A case of alpha chain disease, involving stomach, small and large intestine, and caecum with poor prognosis is reported. Endoscopic examination revealed gastric erosion, edematous mucosa with enlarged villi of duodenum and jejunum, multiple hyperplastic lymph follicles of terminal ileum and thickening mucosa of caecum. Light microscopy revealed a conspicuous infiltration of plasma cells and lymphocytes in gastric, duodenal, jejunal and caecal lamina propria. Immunohistochemistry demonstrated alpha heavy chain protein devoid of light chain in these plasma cells. The patient developed paralytic ileus and died of septic shock on the 179th hospital day.  (+info)

Primary small-intestinal lymphomas in Taiwan: immunoproliferative small-intestinal disease and nonimmunoproliferative small-intestinal disease. (8/9)

PURPOSE: The clinicopathologic findings in 45 adult Chinese patients with primary small-intestinal lymphoma (PSIL) are described and compared with those in Western countries and in underdeveloped nations. The efficacy of combination chemotherapy is also assessed. PATIENTS AND METHOD: Six patients had immunoproliferative small-intestinal disease (IPSID) indicated by the presence of alpha-heavy chain protein (alpha-CP) in body fluids or tumor tissues. Thirty-nine patients had non-IPSID, including one with postrenal transplant lymphoma. Thirty-three non-IPSID patients received a minimum of four cycles of combination chemotherapy with cyclophosphamide, doxorubicin, vincristine, and prednisolone (CHOP). RESULTS: All IPSID patients presented with the clinical and laboratory features of severe intestinal malabsorption, and all had diffuse lymphoplasmacytic infiltration in the mucosa of the small bowel. Lymphomas were localized mainly in the jejunum and mesenteric nodes. The histologic subtypes were diffuse large cell in two, immunoblastic in three, and diffuse mixed in one. All patients responded poorly to chemotherapy, with a median survival duration of 10.5 months. The common presenting symptoms of the 39 non-IPSID patients included abdominal pain (90%), weight loss (31%), abdominal mass (26%), obstruction (26%), and perforation (23%). Diffuse large-cell and immunoblastic lymphomas constituted 82% of cases. Four patients had stage IE, 19 stage II 1E, and 16 stage 112E disease according to the Musshoff's criteria; 22 had bulky tumors and 19 had multiple tumors. The tumors were completely resected in 14 patients. Of 33 patients treated with combination chemotherapy, 73% achieved a complete remission. With a median follow-up duration of 90 months, there have been four relapses, with only one at the primary tumor site. The overall 5-year survival and disease-free survival rates for non-IPSID patients who were treated with chemotherapy were 59% and 54%, respectively. CONCLUSION: Intensive chemotherapy produces long-term disease-free survival in locally advanced non-IPSID PSIL.  (+info)

Immunoproliferative Small Intestinal Disease (IPSID) is a rare condition primarily affecting the small intestine. It is characterized by an excessive proliferation of immune cells, particularly plasma cells, in the lining of the small intestine. This leads to thickening of the intestinal wall, impaired absorption of nutrients, and various gastrointestinal symptoms. IPSID is often associated with a specific type of abnormal protein, called an alpha-defensin, in the stool. It's also known as alpha-defensin enteropathy or Mediterranean lymphoma. The exact cause of IPSID is not fully understood, but it may be linked to chronic antigenic stimulation, such as that caused by certain bacterial infections.

Immunoglobulin alpha-chains (IgA) are a type of immunoglobulin or antibody that plays a crucial role in the immune system. They are composed of two heavy chains, known as alpha-chains, and two light chains. IgA is primarily found in secretions such as tears, saliva, breast milk, and respiratory and intestinal mucus, where they provide protection against pathogens that enter the body through these surfaces.

IgA can exist in two forms: a monomeric form, which consists of a single IgA molecule, and a polymeric form, which consists of several IgA molecules joined together by a J chain. The polymeric form is more common in secretions, where it provides an effective barrier against pathogens.

IgA functions by binding to antigens on the surface of pathogens, preventing them from attaching to and infecting host cells. It can also neutralize toxins produced by some bacteria and viruses. Additionally, IgA can activate the complement system, a group of proteins that work together to destroy pathogens, and initiate an immune response by recruiting other immune cells to the site of infection.

Deficiencies in IgA are relatively common and usually do not cause any significant health problems. However, in some cases, people with IgA deficiency may develop recurrent infections or allergies.

Immunoproliferative disorders are a group of conditions characterized by the abnormal proliferation (overgrowth) of immune cells, leading to the production of large numbers of abnormal antibodies or immunoglobulins. These disorders can result from genetic mutations, infections, autoimmune processes, or malignancies.

Examples of immunoproliferative disorders include:

1. Monoclonal gammopathy of undetermined significance (MGUS): A condition where a single clone of plasma cells produces an abnormal amount of one type of immunoglobulin, which can be detected in the blood. MGUS is not cancerous but may progress to multiple myeloma or other related disorders.
2. Multiple myeloma: A malignant proliferation of a single clone of plasma cells that produce large amounts of abnormal immunoglobulins, leading to bone destruction, anemia, infections, and kidney damage.
3. Waldenström macroglobulinemia: A rare type of lymphoplasmacytic lymphoma where a single clone of B-lymphocytes produces large amounts of abnormal immunoglobulins called IgM, leading to symptoms such as anemia, fatigue, bleeding, and neurological problems.
4. Cryoglobulinemia: A condition characterized by the presence of cryoglobulins (abnormal immunoglobulins) in the blood that precipitate at low temperatures, causing inflammation and damage to small blood vessels.
5. Amyloidosis: A rare disorder where abnormal proteins called amyloid deposits accumulate in various organs and tissues, leading to their dysfunction. In some cases, these proteins are derived from immunoglobulin light chains produced by clonal plasma cells.

Immunoproliferative disorders can have significant clinical consequences, including organ damage, impaired immune function, and increased risk of infections. Proper diagnosis and management require a multidisciplinary approach involving hematologists, oncologists, pathologists, and other specialists.

Malabsorption syndromes refer to a group of disorders in which the small intestine is unable to properly absorb nutrients from food, leading to various gastrointestinal and systemic symptoms. This can result from a variety of underlying conditions, including:

1. Mucosal damage: Conditions such as celiac disease, inflammatory bowel disease (IBD), or bacterial overgrowth that cause damage to the lining of the small intestine, impairing nutrient absorption.
2. Pancreatic insufficiency: A lack of digestive enzymes produced by the pancreas can lead to poor breakdown and absorption of fats, proteins, and carbohydrates. Examples include chronic pancreatitis or cystic fibrosis.
3. Bile acid deficiency: Insufficient bile acids, which are necessary for fat emulsification and absorption, can result in steatorrhea (fatty stools) and malabsorption. This may occur due to liver dysfunction, gallbladder removal, or ileal resection.
4. Motility disorders: Abnormalities in small intestine motility can affect nutrient absorption, as seen in conditions like gastroparesis, intestinal pseudo-obstruction, or scleroderma.
5. Structural abnormalities: Congenital or acquired structural defects of the small intestine, such as short bowel syndrome, may lead to malabsorption.
6. Infections: Certain bacterial, viral, or parasitic infections can cause transient malabsorption by damaging the intestinal mucosa or altering gut flora.

Symptoms of malabsorption syndromes may include diarrhea, steatorrhea, bloating, abdominal cramps, weight loss, and nutrient deficiencies. Diagnosis typically involves a combination of clinical evaluation, laboratory tests, radiologic imaging, and sometimes endoscopic procedures to identify the underlying cause. Treatment is focused on addressing the specific etiology and providing supportive care to manage symptoms and prevent complications.

The small intestine is the portion of the gastrointestinal tract that extends from the pylorus of the stomach to the beginning of the large intestine (cecum). It plays a crucial role in the digestion and absorption of nutrients from food. The small intestine is divided into three parts: the duodenum, jejunum, and ileum.

1. Duodenum: This is the shortest and widest part of the small intestine, approximately 10 inches long. It receives chyme (partially digested food) from the stomach and begins the process of further digestion with the help of various enzymes and bile from the liver and pancreas.
2. Jejunum: The jejunum is the middle section, which measures about 8 feet in length. It has a large surface area due to the presence of circular folds (plicae circulares), finger-like projections called villi, and microvilli on the surface of the absorptive cells (enterocytes). These structures increase the intestinal surface area for efficient absorption of nutrients, electrolytes, and water.
3. Ileum: The ileum is the longest and final section of the small intestine, spanning about 12 feet. It continues the absorption process, mainly of vitamin B12, bile salts, and any remaining nutrients. At the end of the ileum, there is a valve called the ileocecal valve that prevents backflow of contents from the large intestine into the small intestine.

The primary function of the small intestine is to absorb the majority of nutrients, electrolytes, and water from ingested food. The mucosal lining of the small intestine contains numerous goblet cells that secrete mucus, which protects the epithelial surface and facilitates the movement of chyme through peristalsis. Additionally, the small intestine hosts a diverse community of microbiota, which contributes to various physiological functions, including digestion, immunity, and protection against pathogens.

Intestinal diseases refer to a wide range of conditions that affect the function or structure of the small intestine, large intestine (colon), or both. These diseases can cause various symptoms such as abdominal pain, diarrhea, constipation, bloating, nausea, vomiting, and weight loss. They can be caused by infections, inflammation, genetic disorders, or other factors. Some examples of intestinal diseases include inflammatory bowel disease (IBD), irritable bowel syndrome (IBS), celiac disease, Crohn's disease, ulcerative colitis, and intestinal infections. The specific medical definition may vary depending on the context and the specific condition being referred to.

Lymphomatoid Granulomatosis is a rare, progressive and potentially fatal inflammatory disorder characterized by the proliferation of atypical B-lymphocytes infiltrating the lungs, skin, and less frequently other organs. It is considered an angiocentric and angiodestructive lymphoproliferative disease with varying degrees of malignancy. The condition is often associated with Epstein-Barr virus (EBV) infection and is more prevalent in middle-aged men.

The disorder presents with a wide range of symptoms, depending on the affected organs. Lung involvement can cause cough, shortness of breath, chest pain, or hemoptysis, while skin manifestations may include papules, nodules, or ulcers. Other possible sites of involvement are the central nervous system, kidneys, and liver.

Lymphomatoid Granulomatosis is classified into three grades based on the number of atypical lymphocytes and degree of necrosis: grade I (few atypical cells, minimal necrosis), grade II (more atypical cells, mild to moderate necrosis), and grade III (large numbers of atypical cells, extensive necrosis). Grades II and III are considered high-grade lymphomas.

The diagnosis is established through a combination of clinical presentation, radiological findings, and histopathological examination of biopsy specimens. Treatment options include corticosteroids, chemotherapy, immunomodulatory agents, and radiation therapy. The prognosis varies depending on the grade, extent of disease, and response to treatment.

Diverticulitis is a medical condition characterized by the inflammation or infection of one or more diverticula, which are small pouches that form in the wall of the colon (large intestine). The condition most commonly affects the sigmoid colon, which is the part of the colon located in the lower left abdomen.

Diverticulitis occurs when these pouches become inflamed or infected, often as a result of a small piece of stool or undigested food getting trapped inside them. This can cause symptoms such as:

* Severe abdominal pain and tenderness, particularly in the lower left side of the abdomen
* Fever and chills
* Nausea and vomiting
* Constipation or diarrhea
* Bloating and gas
* Loss of appetite

Diverticulitis can range from mild to severe, and in some cases, it may require hospitalization and surgery. Treatment typically involves antibiotics to clear the infection, as well as a liquid diet to allow the colon to rest and heal. In more severe cases, surgery may be necessary to remove the affected portion of the colon.

Intestinal neoplasms refer to abnormal growths in the tissues of the intestines, which can be benign or malignant. These growths are called neoplasms and they result from uncontrolled cell division. In the case of intestinal neoplasms, these growths occur in the small intestine, large intestine (colon), rectum, or appendix.

Benign intestinal neoplasms are not cancerous and often do not invade surrounding tissues or spread to other parts of the body. However, they can still cause problems if they grow large enough to obstruct the intestines or cause bleeding. Common types of benign intestinal neoplasms include polyps, leiomyomas, and lipomas.

Malignant intestinal neoplasms, on the other hand, are cancerous and can invade surrounding tissues and spread to other parts of the body. The most common type of malignant intestinal neoplasm is adenocarcinoma, which arises from the glandular cells lining the inside of the intestines. Other types of malignant intestinal neoplasms include lymphomas, sarcomas, and carcinoid tumors.

Symptoms of intestinal neoplasms can vary depending on their size, location, and type. Common symptoms include abdominal pain, bloating, changes in bowel habits, rectal bleeding, weight loss, and fatigue. If you experience any of these symptoms, it is important to seek medical attention promptly.

"Immunoproliferative Small Intestinal Disease with 40-years of follow-up: A case of cured α-chain disease with recurrent ... Manousos, O.; Economidou, I. (1989). "Immunoproliferative small bowel disease". Gastroenterology. O Manousos, I Economidou. 97 ... "α-Chain disease causing kaliopenic nephropathy and fatal intestinal perforations". The American Journal of Digestive Diseases. ... "Alpha-chain Disease with Clinical, Immunological, and Histological Recovery". O. N. Manousos, J. C. Economidou, D. E. ...
... hodgkin disease MeSH C04.557.386.390 - immunoproliferative small intestinal disease MeSH C04.557.386.480 - lymphoma, non- ... non-small-cell lung MeSH C04.588.894.797.520.235 - carcinoma, small cell MeSH C04.588.894.797.520.240 - coin lesion, pulmonary ... small-cell MeSH C04.557.386.480.700.725 - lymphoma, small cleaved-cell, diffuse MeSH C04.557.386.480.700.725.500 - lymphoma, ... small lymphocytic MeSH C04.557.386.480.700.775 - lymphoma, small noncleaved-cell MeSH C04.557.386.480.750 - lymphoma, t-cell ...
... except for a special subtype of malt lymphoma termed immunoproliferative small intestinal disease that is endemic to the Middle ... small intestinal-localized lymphoma as a distinct disease entity, DFL. DFL, while currently considered a malignant disease, has ... follicular lymphomas of the duodenum and other parts of the small intestine differ from the other forms of primary intestinal ... In virtually all cases of the disease, these cells bear a pathological genomic abnormality that is typical of most but not all ...
... immunoproliferative small intestinal disease MeSH C06.405.469.491.523 - jejunal neoplasms MeSH C06.405.469.531 - intestinal ... immunoproliferative small intestinal disease MeSH C06.301.371.411.523 - jejunal neoplasms MeSH C06.301.371.767 - stomach ... immunoproliferative small intestinal disease MeSH C06.405.249.411.523 - jejunal neoplasms MeSH C06.405.249.767 - stomach ... crohn disease MeSH C06.405.469.445 - intestinal atresia MeSH C06.405.469.452 - intestinal diseases, parasitic MeSH C06.405. ...
... heavy chain disease MeSH C20.683.780.490.512 - immunoproliferative small intestinal disease MeSH C20.683.780.640 - monoclonal ... immunoproliferative small intestinal disease MeSH C20.683.515.515 - infectious mononucleosis MeSH C20.683.515.517 - leukemia, ... small-cell MeSH C20.683.515.761.480.700.725 - lymphoma, small cleaved-cell, diffuse MeSH C20.683.515.761.480.700.725.500 - ... Aleutian mink disease MeSH C20.673.774.535 - granulomatous disease, chronic MeSH C20.673.774.600 - Job's syndrome MeSH C20.683. ...
... disease Mu heavy chain disease Gamma heavy chain disease Franklin disease M9764/3 Immunoproliferative small intestinal disease ... cell M8045/3 Combined small cell carcinoma Mixed small cell carcinoma Combined small cell-large cell carcinoma Combined small ... Paget disease of breast M8541/3 Paget disease and infiltrating duct carcinoma of breast (C50._) M8542/3 Paget disease, ... small B lymphocytic, NOS (see also M9823/3) Small lymphocytic lymphoma Malignant lymphoma, small lymphocytic, NOS Malignant ...
Immunoproliferative small intestinal disease, formerly termed Mediterranean lymphoma or considered a type of alpha heavy chain ... However, it is not clear that this bacterium is the actual cause of immunoproliferative small intestinal disease: it may merely ... In its endemic areas, immunoproliferative small intestinal disease constitutes ~30% of all GI tact lymphomas, mainly afflicts ... Primary small intestinal MZL, also termed primary small intestinal MALT lymphoma, commonly presents with colicky abdominal pain ...
α Heavy chain disease (also termed immunoproliferative small intestinal disease or IPSID, Mediterranean lymphoma, and Seligmann ... γ Heavy chain disease (also termed Franklin disease or Franklin's disease) presents in three patterns: a) aggressive lymphoma ( ... μ Heavy chain disease presents with a picture of a lymphoid neoplasm resembling either chronic lymphocytic leukemia or small ... The heavy chain diseases are classified as α, γ, and μ heavy chain diseases and are based respectively on >400, 130, and 30-40 ...
... heavy chain disease MeSH C15.378.147.780.490.512 - immunoproliferative small intestinal disease MeSH C15.378.147.780.650 - ... heavy chain disease MeSH C15.604.515.435.512 - immunoproliferative small intestinal disease MeSH C15.604.515.509 - ... hemoglobin sc disease MeSH C15.378.420.155.668 - sickle cell trait MeSH C15.378.420.463 - hemoglobin c disease MeSH C15.378. ... small-cell MeSH C15.604.515.569.480.700.725 - lymphoma, small cleaved-cell, diffuse MeSH C15.604.515.569.480.700.725.500 - ...
Malabsorption, or immunoproliferative enteropathy, is an autoimmune intestinal disease that leads to anorexia, chronic diarrhea ... Basenjis are small, short-haired dogs with erect ears, tightly curled tails and graceful necks. A Basenji's forehead is ... A Fanconi disease management protocol has been developed that can be used by veterinarians to treat Fanconi-afflicted dogs. ... Kennel Club/British Small Animal Veterinary Association Scientific Committee. 2004. Purebred Dog Health Survey Archived 13 ...
... autoimmune and immunoproliferative diseases. Gynevac is additionally contraindicated in arthritides affecting several joints, ... Macpherson AJ, Geuking MB, McCoy KD (June 2005). "Immune responses that adapt the intestinal mucosa to commensal intestinal ... Most bacteria found in the uterus in association with preterm labor are of vaginal origin, with only a small minority ... Notably, the majority of intestinal bacterial cells in healthy individuals is bound by sIgA. The sIgA-coating of commensal ...
Immunoproliferative small intestinal disease C88.4 Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid ... Malignant immunoproliferative disease, unspecified C91.50 Adult T-cell lymphoma/leukemia (HTLV-1-associated) not having ... Small cell B-cell lymphoma, intra-abdominal lymph nodes C83.04 Small cell B-cell lymphoma, lymph nodes of axilla and upper limb ... Small cell B-cell lymphoma, intrathoracic lymph nodes C83.03 ... Small cell B-cell lymphoma, spleen C83.08 Small cell B-cell ...
Llymphoma and other named immunoproliferative small intestinal diseases. 200.8, 203.8. C88.3. Bacteremia. 790.7. A49.9. ... The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. ... Intestinal obstruction, irritable colon, megacolon, peritonitis, diverticulitis. 56-0, 562, 564.1, 564.7 567. K56, K57, K58, ... Centers for Disease Control and Prevention. CDC twenty four seven. Saving Lives, Protecting People ...
Lecuit M, Abachin E, Martin A. Immunoproliferative small intestinal disease associated with Campylobacter jejuni. N Engl J Med ... 7, 8] Campylobacter gracilis is associated with periodontal disease, [9] pleuropulmonary disease, and bacteremia. ... In a small number of cases, the infection is associated with the hemolytic-uremic syndrome and thrombotic thrombocytopenic ... Mahmud H Javid, MBBS Consultant in Infectious Diseases, Quaid-e-Azam International Hospital, Pakistan. Mahmud H Javid, MBBS is ...
Immunoproliferative small intestinal disease: Follow-up of an alpha-chain negative, lymphoma-free group. Journal of Clinical ... The spectrum of immunoproliferative small intestinal disease: Clinical features and outcome in 30 cases. Medicine (Baltimore), ... Immunoproliferative small intestinal disease with lymphoma: Diagnostic difficulties and pitfalls. South African Medical Journal ... Plasma cell infiltration of the small bowel: lack of evidence for a nonsecretory form of alpha-heavy chain disease. Gut, 26: , ...
"Immunoproliferative Small Intestinal Disease with 40-years of follow-up: A case of cured α-chain disease with recurrent ... Manousos, O.; Economidou, I. (1989). "Immunoproliferative small bowel disease". Gastroenterology. O Manousos, I Economidou. 97 ... "α-Chain disease causing kaliopenic nephropathy and fatal intestinal perforations". The American Journal of Digestive Diseases. ... "Alpha-chain Disease with Clinical, Immunological, and Histological Recovery". O. N. Manousos, J. C. Economidou, D. E. ...
Immunoproliferative small intestinal disease (morphologic abnormality). Code System Preferred Concept Name. Immunoproliferative ... Immunoproliferative small intestinal disease Active Synonym false false 45914019 Mediterranean lymphoma Active Synonym false ...
Immunoproliferative small intestinal disease (IPSID) is an uncommon disease of the small intestine. There is a similarity in ... Falsely elevated anti-tissue transglutaminase antibodies in patients with immunoproliferative small intestinal diseases: A case ... Correlation between intestinal stem cell niche changes and small bowel crypt failure in patients with treatment-naïve celiac ... OBJECTIVES: We hypothesized that crypt failure in the small bowel results in villous flattening in patients with celiac disease ...
Lecuit M, Abachin E, Martin A. Immunoproliferative small intestinal disease associated with Campylobacter jejuni. N Engl J Med ... In a small number of cases, the infection is associated with hemolytic-uremic syndrome and thrombotic thrombocytopenic purpura ... Taylor DN, McDermott KT, Little JR, et al. Campylobacter enteritis from untreated water in the Rocky Mountains. Ann Intern Med ... Mee AS, Shield M, Burke M. Campylobacter colitis: differentiation from acute inflammatory bowel disease. J R Soc Med. 1985 Mar ...
... immunoproliferative small intestinal disease, septic abortion, and encephalopathy. ... C. fetus is much less common than C. jejuni and is usually an opportunistic pathogen affecting people with underlying disease, ... more often when underlying predisposing diseases, such as diabetes, cirrhosis, cancer, or HIV/AIDS, are present. ... infection from ulcerative colitis Ulcerative Colitis Ulcerative colitis is a chronic inflammatory and ulcerative disease ...
immunoproliferative small intestinal disease. electroconvulsive therapy. craniotomy. ulcer. Medical Abbreviations. NPDB. NPH ... Nursing Central combines Tabers with a medical dictionary, disease manual, lab guide, and useful tools. ...
Immunoproliferative small intestinal disease (IPSID, also called alpha heavy chain disease, Mediterranean lymphoma, Seligmann ... such as immunoproliferative small intestinal disease (IPSID; a variant of MALT lymphoma), celiac disease (enteropathy- ... Immunoproliferative small intestinal disease lymphoma (IPSID), which is a variant of extranodal marginal zone lymphoma of MALT ... Vessal K, Dutz W, Kohout E, Rezvani L. Immunoproliferative small intestinal disease with duodenojejunal lymphoma: radiologic ...
Immunoproliferative Small Intestinal Disease with 40-years of follow-up: A case of cured α-chain disease with recurrent ... Short and long-term results of adalimumab treatment of patients with active Crohns disease: Experience of a Greek single ... Azathioprine use in patients with Inflammatory Bowel Disease. Adherence to treatment and adverse events. A single center ... center for inflammatory bowel disease J.K. Triantafillidis, J. Fouskas, G. Malgarinos, Ch. Malli, A . Gikas, M. Mylonaki, F. ...
His work on Immunoproliferative Small Intestinal Disease (a form of intestinal cancer), and the relationship between infection ... and the development of intestinal cancer has become a classic in modern medicine. ...
Immunoproliferative small intestinal disease?iPTH: ?IPV: Inactivated polio vaccine?IQ: Inhibitory Quotient?IQ: Intelligence ... Variant Creutzfeldt-Jakob Disease?VCUG: Voiding Cystourethrogram?VD: Veneral disease?VDRL: Venereal Disease Research Laboratory ... Small cell lung cancer?SCr: Serum creatinine?SCU: See SCUF?SCUF: Slow continuous ultrafiltration?SD: Stable disease?SD: ... Valvular heart disease?Vi CPS: Vi capsular polysaccharide?VIN: Vulvar intraepithelial neoplasia?VIP: Vasoactive intestinal ...
Immunoproliferative small intestinal disease - a genetic disease commonly seen in Basenjis, this inflammatory bowel disease ... Basenjis are known for their tightly coiled tail, wrinkled forehead, perked ears, little shedding and ability to groom ... Patellar luxation - a common injury in smaller dogs that causes the dogs knee to bend inwards ...
Immunoproliferative small intestinal disease associated with Campylobacter jejuni. N Engl J Med. 2004, 350: 239-248. 10.1056/ ... Jelic S, Filipovic-Ljeskovic I: Positive serology for Lyme disease borrelias in primary cutaneous B-cell lymphoma: a study in ... The treatment depends upon the variables related to the patient (age, autoimmune disorders) and to the disease, particularly on ... Garbe C: Borrelia infections of the skin--progress of knowledge since the discovery of Lyme disease. Hautarzt. 1991, 42: 356- ...
Immunoproliferative small intestinal disease?iPTH: ?IPV: Inactivated polio vaccine?IQ: Inhibitory Quotient?IQ: Intelligence ... collagen disease,dermatilogic diseases,edematous states,gastrointestinal diseases,dermatilogic disease,edematous state, ... Variant Creutzfeldt-Jakob Disease?VCUG: Voiding Cystourethrogram?VD: Veneral disease?VDRL: Venereal Disease Research Laboratory ... alzheimers disease,bleeding tendency,hemorrhage,hemorrhagic,hemorrhage disease,hemorrhagic disease of vitamin k deficiency, ...
Immunoproliferative small intestinal disease?iPTH: ?IPV: Inactivated polio vaccine?IQ: Inhibitory Quotient?IQ: Intelligence ... Variant Creutzfeldt-Jakob Disease?VCUG: Voiding Cystourethrogram?VD: Veneral disease?VDRL: Venereal Disease Research Laboratory ... Small cell lung cancer?SCr: Serum creatinine?SCU: See SCUF?SCUF: Slow continuous ultrafiltration?SD: Stable disease?SD: ... Valvular heart disease?Vi CPS: Vi capsular polysaccharide?VIN: Vulvar intraepithelial neoplasia?VIP: Vasoactive intestinal ...
Immunoproliferative Small Intestinal Disease. ; Lymphoma, Non-Hodgkin. Other names Sarcoma, Germinoblastic; ... Definition: A general term for various neoplastic diseases of the lymphoid tissue. GEN only or unspecified: prefer specific; do ... not confuse X ref LYMPHOMA, MALIGNANT with LYMPHOGRANULOMA, MALIGNANT see HODGKIN DISEASE; for lymphoma with AIDS, use LYMPHOMA ...
Immunoproliferative Small Intestinal Disease [C20.683.515.512] * Infectious Mononucleosis [C20.683.515.515] * Leukemia, Hairy ... Immune System Diseases [C20] * Immunoproliferative Disorders [C20.683] * Lymphoproliferative Disorders [C20.683.515] * ...
Immunoproliferative Small Intestinal Disease. *Intraocular Lymphoma. *Lymphoma, Non-Hodgkin. Below are MeSH descriptors whose ... A malignant disease characterized by progressive enlargement of the lymph nodes, spleen, and general lymphoid tissue. In the ... "Hodgkin Disease" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical Subject ... This graph shows the total number of publications written about "Hodgkin Disease" by people in this website by year, and ...
Immunoproliferative Small Intestinal Disease [C20.683.515.512] * Infectious Mononucleosis [C20.683.515.515] * Leukemia, Hairy ... Immune System Diseases [C20] * Immunoproliferative Disorders [C20.683] * Lymphoproliferative Disorders [C20.683.515] * ... Immune System Diseases [C20] * Immunoproliferative Disorders [C20.683] * Paraproteinemias [C20.683.780] * Cryoglobulinemia [ ... Hemic and Lymphatic Diseases [C15] * Hematologic Diseases [C15.378] * Blood Protein Disorders [C15.378.147] * Paraproteinemias ...
Nonsecretory Variant of Immunoproliferative Small Intestinal Disease: A Case Report With Pathologic, Immunophenotypic, and ... View Articletitled, Nonsecretory Variant of Immunoproliferative Small Intestinal Disease: A Case Report With Pathologic, ... The Effects of Diseases, Drugs, and Chemicals on the Creativity and Productivity of Famous Sculptors, Classic Painters, Classic ... View Articletitled, The Effects of Diseases, Drugs, and Chemicals on the Creativity and Productivity of Famous Sculptors, ...
Immunoproliferative Small Intestinal Disease. *Infectious Mononucleosis. *Leukemia, Hairy Cell. *Leukemia, Lymphoid. * ... A transmissible viral disease of birds caused by avian herpesvirus 2 (HERPESVIRUS 2, GALLID) and other MARDIVIRUS. There is ... "Marek Disease" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical Subject ... This graph shows the total number of publications written about "Marek Disease" by people in this website by year, and whether ...
Immunoproliferative Small Intestinal Disease. *Infectious Mononucleosis. *Leukemia, Hairy Cell. *Leukemia, Lymphoid. * ... Regulatory perspective on minimal residual disease flow cytometry testing in multiple myeloma. Cytometry B Clin Cytom. 2016 Jan ... A multicenter pilot evaluation of the National Institutes of Health chronic graft-versus-host disease (cGVHD) therapeutic ... Kind T. An incurable disease. Acad Med. 2008 Dec; 83(12):1165. ... Hemic and Lymphatic Diseases [C15]. *Hematologic Diseases [ ...
Immunoproliferative Small Intestinal Disease. *Jejunal Neoplasms. *Jejunal Diseases. *Jejunal Neoplasms. Below are MeSH ... Tumors or cancer in the JEJUNUM region of the small intestine (INTESTINE, SMALL). ... Solitary Extramedullary Multiple Myeloma Presenting with Small Bowel Obstruction. J Emerg Med. 2016 Jan; 50(1):e25-7. ...
Immunoproliferative Small Intestinal Disease. *Intraocular Lymphoma. *Lymphoma, Non-Hodgkin. Below are MeSH descriptors whose ...
C88.1 Alpha heavy chain disease C88.2 Gamma heavy chain disease C88.3 Immunoproliferative small intestinal disease C88.7 Other ... K50.0 Crohns disease of small intestine K50.1 Crohns disease of large intestine K50.8 Other Crohns disease K50.9 "Crohns ... K57.0 Diverticular disease of small intestine with perforation and abscess K57.1 Diverticular disease of small intestine ... A07.8 Other specified protozoal intestinal diseases A07.9 "Protozoal intestinal disease, unspecified" A08 Viral and other ...
  • In particular, their work on α-heavy chain disease and Mediterranean Lymphoma was of global impact. (wikipedia.org)
  • Primary small intestinal lymphoma, while uncommon in Western countries, accounts for up to 75 percent of primary GI lymphomas in the Middle East and Mediterranean basin. (medilib.ir)
  • Autoimmune diseases - A variety of autoimmune diseases, including rheumatoid arthritis, Sjögren's disease, systemic lupus erythematosus, and granulomatosis with polyangiitis, have been associated with an increased risk of lymphoma. (medilib.ir)
  • Among environmental factors, some bacterial infections have been found associated to MALT lymphomas of specific anatomic districts, such as H. pylori in gastric MALT lymphoma, C. Jejuni in intestinal MALT lymphoma and Borrelia Burgdoferi in cutaneous B cell lymphoma [ 6 - 10 ]. (biomedcentral.com)
  • Therapy Selection for Hodgkin Lymphoma in Sickle Cell Disease: balancing risks and benefits. (ucdenver.edu)
  • The hydrochloride is an antineoplastic agent used to treat HODGKIN DISEASE and LYMPHOMA. (lookformedical.com)
  • [9] If enlarged lymph nodes are caused by infiltrating CLL-type cells, a diagnosis of small lymphocytic lymphoma (SLL) is made. (wikipedia.org)
  • CLL can be grouped with small lymphocytic lymphoma (SLL) as one disease with two clinical presentations. (wikipedia.org)
  • HHV-4, also known as Epstein-Barr virus (EBV), causes the primary infection infectious mononucleosis , and it is implicated in various diseases, such as African Burkitt lymphoma , other immunoproliferative disorders, and nasopharyngeal carcinoma. (medscape.com)
  • Primary NHLs of the GI tract are rare, accounting for only 1 to 4 percent of malignancies arising in the stomach, small intestine, or colon [ 6 ]. (medilib.ir)
  • Tumors or cancer in the JEJUNUM region of the small intestine (INTESTINE, SMALL). (uams.edu)
  • Carcinoma, Small Intestine. (booksdo.com)
  • See "Epidemiology, clinical features, and types of small bowel neoplasms" . (medilib.ir)
  • A malignant disease characterized by progressive enlargement of the lymph nodes, spleen, and general lymphoid tissue. (ucdenver.edu)
  • Malignant Atrophic Papulosis (Dego&sgrave;Disease). (booksdo.com)
  • Any of a group of malignant tumors of lymphoid tissue that differ from HODGKIN DISEASE, being more heterogeneous with respect to malignant cell lineage, clinical course, prognosis, and therapy. (lookformedical.com)
  • Solitary Extramedullary Multiple Myeloma Presenting with Small Bowel Obstruction. (uams.edu)
  • Intestinal Obstruction. (booksdo.com)
  • Azathioprine use in patients with Inflammatory Bowel Disease. (annalsgastro.gr)
  • Immunoproliferative small intestinal disease - a genetic disease commonly seen in Basenji's, this inflammatory bowel disease creates severe diarrhea and vomiting in a dog that is accompanied by protein loss and malabsorption. (trained2listenk-9.com)
  • Ischaemic Bowel Disease. (booksdo.com)
  • Orestes Manousos published a large number of clinical and research papers on digestive diseases in international medical journals. (wikipedia.org)
  • Cervical vertebrae 1,2, …?Ca: Calcium?Ca: Cancer?Ca: Carcinoma?Ca: Cardiac arrest?Ca: Coronary artery?CA-125: A tumor marker for ovarian cancer?CAB: Cellulose acetate butyrate?CABG: Coronary artery bypass graft?CACI: Computer-Assisted Continuous Infusion?CAD: Coronary artery disease?CAG: ?CAH: Chronic active hepatitis?CAH: Congenital adrenal hyperplasia?calid. (kuwaitpharmacy.com)
  • Glomus Tumor, Gastro-Intestinal. (booksdo.com)
  • Granular Cell Tumor, Gastro-Intestinal. (booksdo.com)
  • Inflammatory Myofibroblastic Tumor, Upper Gastro-Intestinal Tract. (booksdo.com)
  • The only common feature among these tumors is the absence of giant REED-STERNBERG CELLS, a characteristic of Hodgkin's disease. (lookformedical.com)
  • In a small number of cases, the infection is associated with the hemolytic-uremic syndrome and thrombotic thrombocytopenic purpura through a poorly understood mechanism. (medscape.com)
  • His work on Immunoproliferative Small Intestinal Disease (a form of intestinal cancer), and the relationship between infection and the development of intestinal cancer has become a classic in modern medicine. (salemoncology.com)
  • HHV-2, also known as HSV-2, causes genital herpes and occasionally causes oral disease that is clinically similar to that of HHV-1 infection. (medscape.com)
  • HHV-3, also known as varicella-zoster virus (VZV), causes the primary infection chickenpox and the secondary reactivation disease herpes zoster. (medscape.com)
  • A general term for various neoplastic diseases of the lymphoid tissue. (reference.md)
  • In 1964 his research into diverticular disease was acknowledged with the degree of Doctor of Philosophy (Ph.D.) from the University of Oxford. (wikipedia.org)
  • Diverticular Disease, Colon. (booksdo.com)
  • Mucinous Carcinoma, Upper Gastro-Intestinal Tract. (booksdo.com)
  • Centers for Disease Control and Prevention. (cdc.gov)
  • The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. (cdc.gov)
  • The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. (cdc.gov)
  • Campylobacter species are sensitive to hydrochloric acid in the stomach, and antacid treatment can reduce the amount of inoculum needed to cause disease. (medscape.com)
  • While the disease typically involves a single primary site, multiple sites within the GI tract may be involved, as can local and distant lymph nodes. (medilib.ir)
  • Conditions in which acid secretion is blocked, for example, by antacid treatment or disease, predispose patients to Campylobacter infections. (medscape.com)
  • See Cutaneous Manifestations of HIV Disease and Cutaneous Manifestations of Hepatitis C for information on these viral infections. (medscape.com)
  • Herpesviruses establish latent permanent infections in their hosts, although clinical signs of disease may not be detected. (medscape.com)
  • A transmissible viral disease of birds caused by avian herpesvirus 2 (HERPESVIRUS 2, GALLID) and other MARDIVIRUS. (sdsu.edu)
  • [14] The disease most commonly occurs in people over the age of 65, due to the accumulation of genetic mutations that occurs over time. (wikipedia.org)
  • [17] Less commonly, the disease comes to light only after the cancerous cells overwhelm the bone marrow, resulting in low red blood cells, neutrophils, or platelets. (wikipedia.org)
  • Hodgkin Disease" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (ucdenver.edu)
  • This graph shows the total number of publications written about "Hodgkin Disease" by people in this website by year, and whether "Hodgkin Disease" was a major or minor topic of these publications. (ucdenver.edu)
  • Below are the most recent publications written about "Hodgkin Disease" by people in Profiles. (ucdenver.edu)
  • Large cells, usually multinucleate, whose presence is a common histologic characteristic of classical HODGKIN DISEASE. (lookformedical.com)
  • The information in this article contains billing, coding or other guidelines that complement the Local Coverage Determination (LCD) for MolDX: Minimal Residual Disease Testing for Cancer L38814. (codemap.com)
  • HHV-8 is associated with Kaposi sarcoma (KS), and evidence links it with body-cavity lymphomas and Castleman disease. (medscape.com)
  • C. fetus and several other Campylobacter species (eg, C. coli and C. lari ) typically cause bacteremia and systemic manifestations in adults, more often when underlying predisposing diseases, such as diabetes, cirrhosis, cancer, or HIV/AIDS, are present. (msdmanuals.com)
  • Juvenile Polyposis Syndrome, Lower Gastro-Intestinal Tract. (booksdo.com)
  • 1992. A Multicenter, double-blind, randomized, placebo-controlled, comparison of nocturnal Roxatidine in the treatment of active duodenal ulcer disease. (uc.edu)
  • Inflammatory Fibroid Polyp, Lower Gastro-Intestinal Tract. (booksdo.com)
  • Zika virus (ZIKV) is among the relatively new infectious disease threats that include SARS-CoV2, coronavirus, monkeypox (Mpox) virus, etc. (bvsalud.org)
  • An antineoplastic agent used primarily in combination with mechlorethamine, vincristine, and prednisone (the MOPP protocol) in the treatment of Hodgkin's disease. (lookformedical.com)
  • The treatment of a disease or condition by several different means simultaneously or sequentially. (lookformedical.com)
  • Early-stage CLL in asymptomatic cases responds better to careful observation, as there is no evidence that early intervention treatment can alter the course of the disease. (wikipedia.org)
  • 1994. Pancreatitis in patients with end-stage renal disease. (uc.edu)
  • OBJECTIVES: We hypothesized that crypt failure in the small bowel results in villous flattening in patients with celiac disease (CeD). (bvsalud.org)
  • Gaucher's disease complicated by bleeding esophageal varices and colonic infiltration by Gaucher cells. (uc.edu)
  • C. fetus is much less common than C. jejuni and is usually an opportunistic pathogen affecting people with underlying disease, older people, and pregnant women. (msdmanuals.com)
  • A Minimal Residual Disease (MRD) test, as defined in the related policy, is a service that may include multiple components and/or multiple timepoints (i.e., serial assays). (codemap.com)
  • Regulatory perspective on minimal residual disease flow cytometry testing in multiple myeloma. (ctsicn.org)
  • Eight types of HHV have been linked with oral disease. (medscape.com)
  • These types have different disease patterns in their hosts. (medscape.com)
  • Risk factors include having a family history of the disease, with 10% of those who develop CLL having a family history of the disease. (wikipedia.org)
  • All underwent screening for serum anti-tissue transglutaminase and endoscopic upper small bowel biopsy. (bvsalud.org)
  • Adenocarcinoma, Upper Gastro-Intestinal Tract. (booksdo.com)
  • Albumin makes a large contribution to plasma colloid osmotic pressure due to its small size and abundance (35-50% of total plasma proteins by weight). (eclinpath.com)
  • Immunosuppressive therapy, rather than the disease itself, is thought to be responsible for the increased risk. (medilib.ir)