Risk Factors
Availability of immune globulin intravenous for treatment of immune deficient patients--United States, 1997-1998. (1/2589)
Immune globulin intravenous (IGIV) is a lifesaving treatment for patients with primary immunodeficiency. Since November 1997, a shortage of IGIV has existed in the United States. In 1998, the Food and Drug Administration (FDA) required pharmaceutical companies to increase the frequency of reporting on IGIV distribution from biannually to monthly; in addition, FDA facilitated IGIV distribution and informed clinicians about the ongoing shortage. To assess the impact of the IGIV shortage on patient care, in 1998 the Immune Deficiency Foundation (IDF) surveyed physicians caring for immunodeficient patients about whether they have had difficulty obtaining IGIV, measures they have taken because of the shortage, and the effect of the shortage on their patients. This report summarizes data reported to FDA and data obtained from the IDF survey and provides recommendations for IGIV use during the shortage. (+info)Treatment of multiple myeloma. (2/2589)
BACKGROUND AND OBJECTIVE: Multiple myeloma (MM) accounts for about 10% of all hematologic malignancies. The standard treatment with intermittent courses of melphalan and prednisone (MP) was introduced more than 30 years ago and, since then there has been little improvement in event-free and overall survival (EFS & OS). The aim of this article is to review: 1) the role of initial chemotherapy (ChT), maintenance treatment with alpha-interferon and salvage ChT, 2) the results of high-dose therapy (HDT) followed by allogeneic or autologous stem cell transplantation (allo-SCT and auto-SCT), and 3) the most important supportive measures. EVIDENCE AND INFORMATION SOURCES: The authors of this review have been actively working and contributing with original investigations on the treatment of MM during the last 15 years. In addition, the most relevant articles and recent abstracts published in journals covered by the Science Citation Index and Medline are also reviewed. STATE OF THE ART AND PERSPECTIVES: The importance of avoiding ChT in asymptomatic patients (smoldering MM) is emphasized. The criteria and patterns of response are reviewed. MP is still the standard initial ChT with a response rate of 50-60% and an OS of 2-3 years. Combination ChT usually increases the response rate but does not significantly influence survival when compared with MP. Exposure to melphalan should be avoided in patients in whom HDT followed by auto-SCT is planned, in order to not preclude the stem cell collection. The median response duration to initial ChT is 18 months. Interferon maintenance usually prolongs response duration but in most studies does not significantly influence survival (a large meta-analysis by the Myeloma Trialists' Collaborative Group in Oxford is being finished). In alkylating-resistant patients, the best rescue regimens are VBAD or VAD. In patients already resistant to VBAD or VAD and in those in whom these treatments are not feasible we recommend a conservative approach with alternate day prednisone and pulse cyclophosphamide. While HDT followed by autotransplantation is not recommended for patients with resistant relapse, patients with primary refractory disease seem to benefit from early myeloablative therapy. Although results from large randomized trials are still pending in order to establish whether early HDT intensification followed by auto-SCT is superior to continuing standard ChT in responding patients, the favorable experience with autotransplantation of the French Myeloma Intergroup supports this approach. However, although the complete response rate is higher with intensive therapy, the median duration of response is relatively short (median, 16 to 36 months), with no survival plateau. There are several ongoing trials comparing conventional ChT with HDT/autoSCT in order to identify the patients who are likely to benefit from one or another approach. With allo-SCT there is a transplant-related mortality ranging from 30 to 50% and also a high relapse rate in patients achieving CR. However, 10 to 20% of patients undergoing allo-SCT are long-term survivors (> 5 years) with no evidence of disease and, consequently, probably cured. The use of allogeneic peripheral blood stem cells (PBSC) in order to speed the engraftment and also the use of partially T-cell depleted PBSC which can decrease the incidence of graft-versus-host disease are promising approaches. In the setting of allo-SCT, donor lymphocyte infusion is an encouraging strategy in order to treat or prevent relapses. Finally, important supportive measures such as the treatment of anemia with erythropoietin, the management of renal failure and the use of bisphosphonates are reviewed. (+info)Host modulation as a therapeutic strategy in the treatment of periodontal disease. (3/2589)
Specific microorganisms initiate the immunoinflammatory processes that destroy tissue in periodontitis. Recent work has demonstrated, in addition to bacterial control, that modulation of the host immunoinflammatory response is also capable of controlling periodontitis. Matrix metalloproteinases (MMPs) destroy collagen and other matrix components, and the osteoclastic bone remodeling determines the periodontal bone response to a bacterial challenge. Other components of the biology, including cytokines and prostanoids, regulate MMPs and bone remodeling and are also involved in regulating the production of defensive elements, such as antibody. Agents directed at blocking MMPs or osteoclastic activity are effective in reducing periodontitis. Agents that inhibit prostaglandin E2 and selective blockage of specific cytokines have also been effective. Improved knowledge of bacterium-host interactions and of the processes leading to tissue destruction will help to identify targets for host modulation to reduce periodontitis in selected situations. (+info)Airways inflammation among workers in a paper industry. (4/2589)
Exposure to organic dusts may cause airways inflammation in a large proportion of exposed persons. Most studies have relied on questionnaires and spirometry for diagnosis. To assess the possibility of determining the presence of inflammation using clinical diagnostic procedures, a study was undertaken among workers in a paper industry. Participants were 83 workers and 44 controls. Airborne endotoxin and (1-->3)-beta-D-glucan levels at the worksites were determined. The effects of this exposure were evaluated using a questionnaire, spirometry and measurements of airway responsiveness (methacholine) and levels of eosinophil cationic protein (ECP), myeloperoxidase (MPO), and C-reactive protein (CRP) in serum. The workers had a decreased baseline forced expiratory volume in one second (FEV1) and an increased airway responsiveness compared with controls. The concentrations of ECP and MPO were elevated compared with controls. There was a relation between exposure to endotoxin and (1-->3)-beta-D-glucan and airway responsiveness as well as ECP levels, when controlling for age, sex, smoking habits, atopy and asthma. The results suggest an increased prevalence of subjective respiratory symptoms, and an increased airway responsiveness among exposed workers. There was also a relationship between the serum concentration of eosinophil cationic protein and airway responsiveness. Taken together, the results suggest the presence of airways inflammation in the workers. (+info)Interleukin-10-induced CD8 cell proliferation. (5/2589)
Interleukin (IL)-10, a product of T helper 2 (Th2) lymphocytes, has been shown to be an important regulator of lymphoid and myeloid cells, inhibiting mitogen, peptide and alloantigen-induced T-cell proliferation and IL-2 production. The microenvironment at the time of cell activation, notably the presence or absence of cytokines such as IL-10, interferon-gamma (IFN-gamma) and IL-2, is believed to determine the lineage and magnitude of cell-mediated responses. In this study, we show that recombinant human IL-10 (rhIL-10) exerts a dose-dependent inhibitory effect on human peripheral blood mononuclear cells stimulated in vitro, when these cells have not previously been exposed to rhIL-10. Furthermore, incubation of these cells with high doses of rhIL-10, either before or at the time of activation, results in inhibition which is followed several days later by the emergence of a population of CD8 positive cells. This rhIL-10-responsive CD8, positive cell population still emerges even when the cells are washed following incubation with rhIL-10 prior to cell activation. Using purified CD8 populations this was shown to be a direct action of rhIL-10 on CD8 cells and not via CD4 positive cells and monocytes. This finding was only observed when cells were activated with a cross-linking anti-CD3 antibody and not when activated with phorbol-12-mystrate-13-acetate (PMA) and calcium ionophore (CaIon), suggesting that the effect is mediated through cell-surface receptors. Analysis of CD8 positive clones reveal production of Tc2 patterns of cytokines and reduced cell cytotoxicity to allogeneic, natural killer and lymphokine activated cell targets. (+info)Autologous transplantation in multiple myeloma: a GITMO retrospective analysis on 290 patients. Gruppo Italiano Trapianti di Midollo Osseo. (6/2589)
BACKGROUND AND OBJECTIVE: Autologous transplantation is a better treatment for multiple myeloma (MM) than chemotherapy, but uncertainty remains about patient selection, optimal timing of autograft, conditioning regimen, need for a second autograft, and role of maintenance. To provide partial answers to these questions we assessed the results of autologous transplantation in a large cohort of patients whose data were reported to the GITMO registry. DESIGN AND METHODS: We retrospectively analyzed data from 290 patients with MM (M = 150; F = 140; median age 52 years, range 19-70; stage I = 34, stage II = 75, stage III = 167) reported to the GITMO. At the time of autograft, 20% were in CR, 66% in PR, while the remaining had non-responsive or progressive disease. Median time between diagnosis and transplant was 16 months (1-90). Seventy-two patients (26%) had been planned to receive a double autograft, but this was actually done in only 35 (12%). The conditioning was chemotherapy in 90%. Peripheral blood was the only source of stem cells in 94%, and purging was applied in 10% of cases. For statistical analysis of data, differences between patient subsets were analyzed using the chi-square test, while the Kaplan-Meier method was used to estimate event-free survival (EFS) and survival (OS) probabilities. The Cox model was used for multivariate analysis. RESULTS: Following the autograft, 116 patients (40%) were in CR, 144 (50%) in PR, 24 (8%) did not respond or progressed and 6 (2%) died before response evaluation. Transplant-related mortality occurred in 3%. At a median follow-up of 23 months, 223 (77%) patients are alive, 71 (24%) of them in CR, and 67 (23%) patients have died at a median time of 20 months (0-70). OS and EFS at 6 years are 47% and 28%, respectively, but the EFS curve shows no plateau. In multivariate analysis, age, beta2-microglobulin level and status at transplant emerged as significant prognostic factors for both OS and EFS, while time from diagnosis to transplant showed borderline significance. INTERPRETATION AND CONCLUSIONS: Based on the prognostic factors identified in multivariate analysis, we were able to assess the weight of a single prognostic factor or their combinations on transplant outcome. We also calculated the probability of OS and EFS by the number of factors at the time of autograft. Autologous transplantation is a safe and effective procedure, not only in sensitive patients, but also in resistant cases, provided they are <55 years of age and have low beta2-microglobulin. It should be applied early after the diagnosis of multiple myeloma, following the delivery of brief primary chemotherapy. (+info)Beta-glucan, a "specific" biologic response modifier that uses antibodies to target tumors for cytotoxic recognition by leukocyte complement receptor type 3 (CD11b/CD18). (7/2589)
beta-Glucans were identified 36 years ago as a biologic response modifier that stimulated tumor rejection. In vitro studies have shown that beta-glucans bind to a lectin domain within complement receptor type 3 (CR3; known also as Mac-1, CD11b/CD18, or alphaMbeta2-integrin, that functions as an adhesion molecule and a receptor for factor I-cleaved C3b, i.e., iC3b) resulting in the priming of this iC3b receptor for cytotoxicity of iC3b-opsonized target cells. This investigation explored mechanisms of tumor therapy with soluble beta-glucan in mice. Normal mouse sera were shown to contain low levels of Abs reactive with syngeneic or allogeneic tumor lines that activated complement, depositing C3 onto tumors. Implanted tumors became coated with IgM, IgG, and C3, and the absent C3 deposition on tumors in SCID mice was reconstituted with IgM or IgG isolated from normal sera. Therapy of mice with glucan- or mannan-rich soluble polysaccharides exhibiting high affinity for CR3 caused a 57-90% reduction in tumor weight. In young mice with lower levels of tumor-reactive Abs, the effectiveness of beta-glucan was enhanced by administration of a tumor-specific mAb, and in SCID mice, an absent response to beta-glucan was reconstituted with normal IgM or IgG. The requirement for C3 on tumors and CR3 on leukocytes was highlighted by therapy failures in C3- or CR3-deficient mice. Thus, the tumoricidal function of CR3-binding polysaccharides such as beta-glucan in vivo is defined by natural and elicited Abs that direct iC3b deposition onto neoplastic cells, making them targets for circulating leukocytes bearing polysaccharide-primed CR3. Therapy fails when tumors lack iC3b, but can be restored by tumor-specific Abs that deposit iC3b onto the tumors. (+info)Sequential biochemical modulation of fluorouracil with folinic acid, N-phosphonacetyl-L-aspartic acid, and interferon alfa-2a in advanced colorectal cancer. (8/2589)
PURPOSE: Several agents have been evaluated for their effect as biochemical modulators of fluorouracil (5-FU) in the treatment of metastatic colorectal carcinoma. In this study, we used folinic acid (FA), N-phosphonacetyl-L-aspartic acid (PALA), and recombinant interferon alfa-2a (IFNalpha-2a) in a sequential order to assess the efficacy of this approach in patients with metastatic colorectal carcinoma. PATIENTS AND METHODS: Forty-four patients with metastatic colorectal carcinoma were enrolled onto the study. The treatment course consisted of three cycles: (cycle 1) FA 20 mg/m(2) followed by 5-FU 425 mg/m(2) on days 1 to 5; (cycle 2) PALA 250 mg/m(2) on days 29, 36, 43, and 50 and 5-FU 2,600 mg/m(2) as a 24-hour infusion on days 30, 37, 44, and 51; and (cycle 3) IFNalpha-2a 9 million units (MU) three times a week for 5 weeks beginning on day 57, with a continuous infusion of 5-FU 750 mg/m(2) on days 57 to 61, and then weekly bolus of 5-FU 750 mg/m(2)/wk on days 71, 78, and 85. Response was determined after cycle 3. RESULTS: All patients had a Zubrod performance status >/= 2, measurable disease, and had received no prior chemotherapy for their metastatic disease. A total of 212 cycles were given. Thirty-six patients were assessable for response. No complete responses were seen. Seven patients had a partial response, eight had stable disease, and 15 had progressive disease. The median duration of response was 25 weeks, and the median survival was 53 weeks. Grade 3 and 4 toxic effects included granulocytopenia, stomatitis, diarrhea, rash, nausea, and fatigue. CONCLUSION: This trial provided no evidence that sequential biochemical modulation of 5-FU in patients with metastatic colorectal carcinoma had any therapeutic advantage over conventional treatment regimens of 5-FU plus FA. (+info)Medical Definition:
"Risk factors" are any attribute, characteristic or exposure of an individual that increases the likelihood of developing a disease or injury. They can be divided into modifiable and non-modifiable risk factors. Modifiable risk factors are those that can be changed through lifestyle choices or medical treatment, while non-modifiable risk factors are inherent traits such as age, gender, or genetic predisposition. Examples of modifiable risk factors include smoking, alcohol consumption, physical inactivity, and unhealthy diet, while non-modifiable risk factors include age, sex, and family history. It is important to note that having a risk factor does not guarantee that a person will develop the disease, but rather indicates an increased susceptibility.
Immunologic factors refer to the elements of the immune system that contribute to the body's defense against foreign substances, infectious agents, and cancerous cells. These factors include various types of white blood cells (such as lymphocytes, neutrophils, monocytes, and eosinophils), antibodies, complement proteins, cytokines, and other molecules involved in the immune response.
Immunologic factors can be categorized into two main types: innate immunity and adaptive immunity. Innate immunity is the non-specific defense mechanism that provides immediate protection against pathogens through physical barriers (e.g., skin, mucous membranes), chemical barriers (e.g., stomach acid, enzymes), and inflammatory responses. Adaptive immunity, on the other hand, is a specific defense mechanism that develops over time as the immune system learns to recognize and respond to particular pathogens or antigens.
Abnormalities in immunologic factors can lead to various medical conditions, such as autoimmune disorders, immunodeficiency diseases, and allergies. Therefore, understanding immunologic factors is crucial for diagnosing and treating these conditions.
B-cell activating factor
Atorolimumab
Immunologic adjuvant
PTPRN
NT5E
Nonspecific immune cell
Miscarriage
Lipophilic bacteria
Pseudomonas aeruginosa
Neurotrophin-3
Sjögren syndrome
Factor XI
Turtle fibropapillomatosis
Haptic perception
Atopic dermatitis
PIBF1
VLA-4
Immunologic activation
Adenosine deaminase 2 deficiency
Macrophage colony-stimulating factor
James L. Gulley
Alton Sutnick
Contact dermatitis
Cell damage
GM3
Angioedema
Morolimumab
Interleukin 8
Public health genomics
Geniposide
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Genetic11
- The international collaborative study COVID Human Genetic Effort (COVIDHGE), in which the Hospital Complex of Navarre (CHN) and the Navarrabiomed Clinical Trials Platform took part, has shown that genetic and immunologic factors that affect the severity of the disease are found in approximately 15% of severe cases of COVID-19. (navarrabiomed.es)
- Abnormality in this molecule is due to genetic or immunologic factors that prevent the body's cells from defending themselves against the coronavirus, which may leave the patient in a severe clinical condition. (navarrabiomed.es)
- The results recently published in two articles in the journal Science partially solve the mystery of why some young, healthy people suffer severe COVID-19 by linking incidence to genetic and immunologic factors. (navarrabiomed.es)
- These findings will make it possible to more accurately select candidates for the different clinical trials in progress to assess the utility of treatment with interferon or blockers of these antibodies, aimed at counteracting the consequences of these genetic and immunologic factors involved in some severe forms of COVID-19", said Dr. Aguilera. (navarrabiomed.es)
- As this frightening pandemic has spread rapidly throughout the world, the sometimes contradictory reports of its manifestations should be understood in the context of the heterogeneous populations that have been infected, and the immense spectrum of genetic predispositions, coexisting risk factors and pre-existing medications that can hinder cohesive understanding. (nature.com)
- The exact cause of pediatric Crohn's disease is not fully understood, but this is thought to develop because of multiple different factors occurring together including genetic, immunologic and environmental triggers. (rarediseases.org)
- Etiologies include immunologic and genetic factors. (definitions.net)
- however, it is thought to be the result of a combination of genetic and immunologic factors. (psychiatrist.com)
- What initiates the autoimmune reaction in Crohn's disease is unclear, but genetic and environmental factors play roles. (hdkino.org)
- Role of factor XIII in fibrin clot formation and effects of genetic polymorphisms. (medscape.com)
- Environmental, genetic, and immunologic factors appear to play a role. (medscape.com)
Virologic1
- Determine the immunologic and virologic effects of IL-12 in these patients. (knowcancer.com)
Antigen6
- BAFF is the natural ligand of three nonconventional tumor necrosis factor receptors named BAFF-R (BR3), TACI (transmembrane activator and calcium modulator and cyclophilin ligand interactor), and BCMA (B-cell maturation antigen), all of which have differing binding affinities for it. (wikipedia.org)
- [4] BAFF is the natural ligand of three unusual tumor necrosis factor receptors named BAFF-R (BR3), TACI (transmembrane activator and calcium modulator and cyclophilin ligand interactor), and BCMA (B-cell maturation antigen), all of which have differing binding affinities for it. (wikidoc.org)
- Drugs or contact allergens can cause lichenoid reactions as the main differential diagnosis of LP. LP is a T-cell mediated immunologic disease but the responsible antigen remains unidentified. (hindawi.com)
- The detection of anti-HBs is indicative of a prior immunologic exposure to the antigen or vaccine. (cdc.gov)
- Anaphylaxis is a systemic, immediate hypersensitivity reaction mediated by factors released from interactions between immunoglobulin E (IgE) and mast cells that produce an antigen-antibody reaction. (cancernetwork.com)
- Factor XIIIa and factor XIIIb antigen levels can be quantified by means of enzyme-linked immunosorbent assay (ELISA). (medscape.com)
Humans2
- B-cell activating factor (BAFF) also known as tumor necrosis factor ligand superfamily member 13B and CD257 among other names, is a protein that in humans is encoded by the TNFSF13B gene. (wikipedia.org)
- Detection in the 1970s of a related orthopoxvirus that causes monkeypox, a similar but milder illness in humans that can be fatal in up to 10 percent of patients, raised concerns that this virus may replace the ecologic and immunologic niche created by the eradication of smallpox. (cdc.gov)
Virulence1
- Borrelia peptidoglycan interacting Protein (BpiP) contributes to the fitness of Borrelia burgdorferi against host-derived factors and influences virulence in mouse models of Lyme disease. (ouhsc.edu)
Epidemiology1
- epidemiology and phenotypic, immunologic and molecular diagnostic methods. (elsevier.es)
Antibodies4
- The subset of patients with anti-Ro/La antibodies had the highest prevalence of most systemic, hematologic, and immunologic alterations (higher frequency of Raynaud phenomenon, altered parotid scintigraphy, positive salivary gland biopsy, peripheral neuropathy, thrombocytopenia, and rheumatoid factor). (nih.gov)
- Specific antibodies to the low ionic strength components inhibited factor VIII activity in normal plasma, but the residual factor VIII was higher than that after inhibition with antibodies against intact factor VIII. (ashpublications.org)
- Both antibodies interfered with von Willebrand factor activity. (ashpublications.org)
- One category of immunologic problems that can cause miscarriages are the antiphospholipid antibodies . (resolve.org)
Reaction3
- Is there an immunologic reaction? (harvard.edu)
- The explant-mixed epidermal lymphocyte reaction system gave consistent, reproducible results and may prove useful for the allocation of an immune protection factor to all sunscreens. (bentham.co.uk)
- The 2 methods used to measure the enzymatic activity of factor XIII include measurement of synthetic amine incorporation into a fibrin clot, and measurement of ammonium ion release during the transglutaminase reaction. (medscape.com)
Tissues1
- We utilize a combination of physiologic mouse models, human tissues, advanced immunologic tools, and cutting-edge quantitative imaging. (seattlechildrens.org)
Diagnostic2
- Hypocomplementemia was associated with a higher frequency of vasculitis and lymphoma, and cryoglobulins with a higher frequency of parotid enlargement, vasculitis, and leukopenia.Epidemiologic, clinical, and analytical features have a significant impact on the clinical presentation of primary SS, influencing the results of the main diagnostic tests, the prevalence and diversity of extraglandular involvement, and the frequency of the main immunologic markers. (nih.gov)
- Better demand for diagnostic procedures, policy coverage, high-level of awareness, and others are some of the significant factors that can inspire the market growth. (medgadget.com)
Sunlight1
- Exposure of skin to sunlight also depends on multiple lifestyle factors (eg, clothing, occupation, recreational activities). (msdmanuals.com)
Clinical2
- Methods In this study we describe treatment interruption patterns over time among clients who interrupt and subsequently resume HAART, and those who are continuously engaged in treatment, and determine clinical factors associated with loss to engagement.An observational, longitudinal, retrospective cohort design was engaged, using secondary treatment program data. (researchgate.net)
- Delayed umbilical bleeding--a presenting feature for factor XIII deficiency: clinical features, genetics, and management. (medscape.com)
Tumor necros2
- BAFF is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. (wikipedia.org)
- Nerve cells do so by releasing neuromediators such as substance P (SP), which acts on both the vascular bed to cause vasodilation and increase permeability, and on skin cells to promote the release of pro-inflammatory cytokines including some interleukins (IL-1 and IL-8) and tumor necrosis factor-alpha (TNF-α). (cosmeticsandtoiletries.com)
Infection1
- In so doing, we have uncovered a dominant factor (TGFβ) that limits immunity within the granuloma, gained insight into aspects of the early events of Mycobacterium tuberculosis (Mtb) infection, and characterized organizational features of tuberculous granulomas. (seattlechildrens.org)
Rheumatoid factor1
- Rheumatoid factor (RF) and anti-cyclic citrullinated peptide (anti-CCP) antibody are usually negative. (unboundmedicine.com)
Interactions1
- Factors like brain-gut axis interactions, immunologic disturbances, oxidative stress, and vagus nerve dysfunction can cause inflammatory bowel disease and mental disorders. (psychiatrist.com)
Quantitative1
- A quantitative assay is required to confirm the diagnosis of factor XIII deficiency. (medscape.com)
MeSH1
- Immunologic Factors" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (ouhsc.edu)
Identify2
- We conducted a population-based, frequency-matched case-control study in Sicily to further investigate the reported inverse relationship between smoking and classical Kaposi sarcoma and to identify other factors associated with altered risk. (aacrjournals.org)
- Identify key concepts of the immunologic and neuropathologic disease processes associated with multiple sclerosis. (hcplive.com)
Reduction1
- Dialysis of factor VIII against buffers of low ionic strength led, however, to a decrease in factor VIII procoagulant activity and the reduction of the correcting activities, which suggested that the intact aggregate was required for procoagulant activity and for von Willebrand factor activity. (ashpublications.org)
Determine2
- Since dialysis of human factor VIII against buffers of low ionic strength yielded two distinct components, and since the factor VIII fraction isolated from normal plasma showed von Willebrand factor activity as defined by the corrective effect on abnormal platelet retention and ristocetin aggregation in von Willebrand's disease, the present studies were performed to determine if the correcting activities could be attributed to one or both of the components. (ashpublications.org)
- Determine the effect of IL-12 on angiogenic factors, including basic fibroblast growth factor, vascular endothelial growth factor, and interferon-inducible protein 10 in these patients. (knowcancer.com)
Disease1
- Immunologic and inflammatory diseases contribute to the progression of the disease. (emedicinehealth.com)
Biological factors1
- Cartilage destruction is a result of several mechanical and biological factors rather than a single entity. (emedicinehealth.com)
Influence1
- The identified transcription factors influence both the global and specific gene expression of the BCLs and have possible implications for diagnosis and treat- ment. (lu.se)
Patients3
- Young-onset patients had a low degree of sicca involvement (xerostomia and parotid enlargement) and a high frequency of immunologic markers (anti-Ro/SS-A and low C4 levels). (nih.gov)
- Objective: To investigate the effects of TH9507, a novel growth hormone releasing factor, on abdominal fat accumulation, metabolic and safety parameters in HIV-infected patients with central fat accumulation. (natap.org)
- Clarify the appropriate use of immunologic (CD4 count) monitoring in the care of patients with HIV. (hivguidelines.org)
Diagnosis1
- Problems relating to the laboratory diagnosis of factor XIII deficiency: a UK NEQAS study. (medscape.com)
Mechanisms1
- The underlying mechanisms do not appear to be primary immunologic or allergic in nature. (cosmeticsandtoiletries.com)
Regulation1
- Ichinose A. Physiopathology and regulation of factor XIII. (medscape.com)
Include2
- Precipitating factors include herpes simplex virus (HSV), Epstein-Barr virus (EBV), and histoplasmosis. (medscape.com)
- It is believed that reasons for these racial disparities may include socioeconomic factors, but the true causes are not fully understood. (managedhealthcareexecutive.com)
Blood1
- Ichinose A, Asahina T, Kobayashi T. Congenital blood coagulation factor XIII deficiency and perinatal management. (medscape.com)
Soluble1
- B-lymphocytes may propagate demyelination and neurodegeneration, most likely by producing soluble neurotoxic factors. (frontiersin.org)
Result1
- These factors can result in admission to the ICU and even death. (navarrabiomed.es)
Higher1
- At the end of follow-up, the hazard of unfavorable treatment outcome (dead, lost, stopped HAART) for clients who restarted treatment at months 6, 12, 18 and 24 was higher by a factor of 1.9, 2.4, 2.6 and 2.4, as compared to those who never discontinued treatment at those times. (researchgate.net)
Play1
- Some researchers believe that immunologic differences may also play a role. (managedhealthcareexecutive.com)
Transmission1
- Testing for anti-HBs can be useful for: a) evaluating the recovery and prognosis of patents infected with HBV, b) screening for potential vaccine recipients, and c) epidemiologic factors associated with transmission of HBV. (cdc.gov)
Risk3
- However, risk factors for post-vaccination fatal COVID-19 are largely unknown. (nature.com)
- In fact, recent or recurrent herpes has been reported as the principle risk factor for erythema multiforme. (medscape.com)
- And those in purple are recommended for adults with additional risk factors or another indication. (cdc.gov)
Specific1
- The two low ionic strength components were identified by the use of a rabbit antiserum against factor VIII, and could be distinguished on the basis of specific antigenic structures. (ashpublications.org)
Normal1
- Results from standard hemostatic screening tests such as activated partial thromboplastin time (aPTT) and international normalized ratio (INR) assessments are normal in factor XIII (FXIII) deficiency. (medscape.com)
Role1
- The role of a missing intermediate factor that inflammation modifies differently in BD and UC is another possibility. (psychiatrist.com)
Agent1
- Ecologic factors, including changes in the environment and agent reservoirs, also might have contributed to changes in the incidence of monkeypox. (cdc.gov)
Studies2
- Additional studies have revealed a broad anti-inflammatory effect of α-MSH apparently mediated by a modulation of nuclear factor κ-β activity (NF-κβ). (cosmeticsandtoiletries.com)
- Several studies have suggested a lack of correlation between sunscreen sun protection factor and protection of skin immune system, potentially allowing greater damage to the skin by removing the natural protective erythemal response to sun exposure. (bentham.co.uk)
Function1
- Dialysis of factor VIII at low ionic strength led to a decrease in antigenic determinants closely related to factor VIII function. (ashpublications.org)
Change1
- Secondary endpoints included change in insulin-like growth factor-I (IGF-I), metabolic, quality of life, and safety parameters. (natap.org)
Shown1
- B-cell activating factor has been shown to interact with TNFRSF13B, TNFSF13, TNFRSF13C, and TNFRSF17. (wikipedia.org)
Major1
- This graph shows the total number of publications written about "Immunologic Factors" by people in this website by year, and whether "Immunologic Factors" was a major or minor topic of these publications. (ouhsc.edu)
Develop1
- The purpose of this study was to develop an in vitro system for testing the immunologic protection afforded by sunscreens in human skin. (bentham.co.uk)