An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.
Biologically active substances whose activities affect or play a role in the functioning of the immune system.

Availability of immune globulin intravenous for treatment of immune deficient patients--United States, 1997-1998. (1/2589)

Immune globulin intravenous (IGIV) is a lifesaving treatment for patients with primary immunodeficiency. Since November 1997, a shortage of IGIV has existed in the United States. In 1998, the Food and Drug Administration (FDA) required pharmaceutical companies to increase the frequency of reporting on IGIV distribution from biannually to monthly; in addition, FDA facilitated IGIV distribution and informed clinicians about the ongoing shortage. To assess the impact of the IGIV shortage on patient care, in 1998 the Immune Deficiency Foundation (IDF) surveyed physicians caring for immunodeficient patients about whether they have had difficulty obtaining IGIV, measures they have taken because of the shortage, and the effect of the shortage on their patients. This report summarizes data reported to FDA and data obtained from the IDF survey and provides recommendations for IGIV use during the shortage.  (+info)

Treatment of multiple myeloma. (2/2589)

BACKGROUND AND OBJECTIVE: Multiple myeloma (MM) accounts for about 10% of all hematologic malignancies. The standard treatment with intermittent courses of melphalan and prednisone (MP) was introduced more than 30 years ago and, since then there has been little improvement in event-free and overall survival (EFS & OS). The aim of this article is to review: 1) the role of initial chemotherapy (ChT), maintenance treatment with alpha-interferon and salvage ChT, 2) the results of high-dose therapy (HDT) followed by allogeneic or autologous stem cell transplantation (allo-SCT and auto-SCT), and 3) the most important supportive measures. EVIDENCE AND INFORMATION SOURCES: The authors of this review have been actively working and contributing with original investigations on the treatment of MM during the last 15 years. In addition, the most relevant articles and recent abstracts published in journals covered by the Science Citation Index and Medline are also reviewed. STATE OF THE ART AND PERSPECTIVES: The importance of avoiding ChT in asymptomatic patients (smoldering MM) is emphasized. The criteria and patterns of response are reviewed. MP is still the standard initial ChT with a response rate of 50-60% and an OS of 2-3 years. Combination ChT usually increases the response rate but does not significantly influence survival when compared with MP. Exposure to melphalan should be avoided in patients in whom HDT followed by auto-SCT is planned, in order to not preclude the stem cell collection. The median response duration to initial ChT is 18 months. Interferon maintenance usually prolongs response duration but in most studies does not significantly influence survival (a large meta-analysis by the Myeloma Trialists' Collaborative Group in Oxford is being finished). In alkylating-resistant patients, the best rescue regimens are VBAD or VAD. In patients already resistant to VBAD or VAD and in those in whom these treatments are not feasible we recommend a conservative approach with alternate day prednisone and pulse cyclophosphamide. While HDT followed by autotransplantation is not recommended for patients with resistant relapse, patients with primary refractory disease seem to benefit from early myeloablative therapy. Although results from large randomized trials are still pending in order to establish whether early HDT intensification followed by auto-SCT is superior to continuing standard ChT in responding patients, the favorable experience with autotransplantation of the French Myeloma Intergroup supports this approach. However, although the complete response rate is higher with intensive therapy, the median duration of response is relatively short (median, 16 to 36 months), with no survival plateau. There are several ongoing trials comparing conventional ChT with HDT/autoSCT in order to identify the patients who are likely to benefit from one or another approach. With allo-SCT there is a transplant-related mortality ranging from 30 to 50% and also a high relapse rate in patients achieving CR. However, 10 to 20% of patients undergoing allo-SCT are long-term survivors (> 5 years) with no evidence of disease and, consequently, probably cured. The use of allogeneic peripheral blood stem cells (PBSC) in order to speed the engraftment and also the use of partially T-cell depleted PBSC which can decrease the incidence of graft-versus-host disease are promising approaches. In the setting of allo-SCT, donor lymphocyte infusion is an encouraging strategy in order to treat or prevent relapses. Finally, important supportive measures such as the treatment of anemia with erythropoietin, the management of renal failure and the use of bisphosphonates are reviewed.  (+info)

Host modulation as a therapeutic strategy in the treatment of periodontal disease. (3/2589)

Specific microorganisms initiate the immunoinflammatory processes that destroy tissue in periodontitis. Recent work has demonstrated, in addition to bacterial control, that modulation of the host immunoinflammatory response is also capable of controlling periodontitis. Matrix metalloproteinases (MMPs) destroy collagen and other matrix components, and the osteoclastic bone remodeling determines the periodontal bone response to a bacterial challenge. Other components of the biology, including cytokines and prostanoids, regulate MMPs and bone remodeling and are also involved in regulating the production of defensive elements, such as antibody. Agents directed at blocking MMPs or osteoclastic activity are effective in reducing periodontitis. Agents that inhibit prostaglandin E2 and selective blockage of specific cytokines have also been effective. Improved knowledge of bacterium-host interactions and of the processes leading to tissue destruction will help to identify targets for host modulation to reduce periodontitis in selected situations.  (+info)

Airways inflammation among workers in a paper industry. (4/2589)

Exposure to organic dusts may cause airways inflammation in a large proportion of exposed persons. Most studies have relied on questionnaires and spirometry for diagnosis. To assess the possibility of determining the presence of inflammation using clinical diagnostic procedures, a study was undertaken among workers in a paper industry. Participants were 83 workers and 44 controls. Airborne endotoxin and (1-->3)-beta-D-glucan levels at the worksites were determined. The effects of this exposure were evaluated using a questionnaire, spirometry and measurements of airway responsiveness (methacholine) and levels of eosinophil cationic protein (ECP), myeloperoxidase (MPO), and C-reactive protein (CRP) in serum. The workers had a decreased baseline forced expiratory volume in one second (FEV1) and an increased airway responsiveness compared with controls. The concentrations of ECP and MPO were elevated compared with controls. There was a relation between exposure to endotoxin and (1-->3)-beta-D-glucan and airway responsiveness as well as ECP levels, when controlling for age, sex, smoking habits, atopy and asthma. The results suggest an increased prevalence of subjective respiratory symptoms, and an increased airway responsiveness among exposed workers. There was also a relationship between the serum concentration of eosinophil cationic protein and airway responsiveness. Taken together, the results suggest the presence of airways inflammation in the workers.  (+info)

Interleukin-10-induced CD8 cell proliferation. (5/2589)

Interleukin (IL)-10, a product of T helper 2 (Th2) lymphocytes, has been shown to be an important regulator of lymphoid and myeloid cells, inhibiting mitogen, peptide and alloantigen-induced T-cell proliferation and IL-2 production. The microenvironment at the time of cell activation, notably the presence or absence of cytokines such as IL-10, interferon-gamma (IFN-gamma) and IL-2, is believed to determine the lineage and magnitude of cell-mediated responses. In this study, we show that recombinant human IL-10 (rhIL-10) exerts a dose-dependent inhibitory effect on human peripheral blood mononuclear cells stimulated in vitro, when these cells have not previously been exposed to rhIL-10. Furthermore, incubation of these cells with high doses of rhIL-10, either before or at the time of activation, results in inhibition which is followed several days later by the emergence of a population of CD8 positive cells. This rhIL-10-responsive CD8, positive cell population still emerges even when the cells are washed following incubation with rhIL-10 prior to cell activation. Using purified CD8 populations this was shown to be a direct action of rhIL-10 on CD8 cells and not via CD4 positive cells and monocytes. This finding was only observed when cells were activated with a cross-linking anti-CD3 antibody and not when activated with phorbol-12-mystrate-13-acetate (PMA) and calcium ionophore (CaIon), suggesting that the effect is mediated through cell-surface receptors. Analysis of CD8 positive clones reveal production of Tc2 patterns of cytokines and reduced cell cytotoxicity to allogeneic, natural killer and lymphokine activated cell targets.  (+info)

Autologous transplantation in multiple myeloma: a GITMO retrospective analysis on 290 patients. Gruppo Italiano Trapianti di Midollo Osseo. (6/2589)

BACKGROUND AND OBJECTIVE: Autologous transplantation is a better treatment for multiple myeloma (MM) than chemotherapy, but uncertainty remains about patient selection, optimal timing of autograft, conditioning regimen, need for a second autograft, and role of maintenance. To provide partial answers to these questions we assessed the results of autologous transplantation in a large cohort of patients whose data were reported to the GITMO registry. DESIGN AND METHODS: We retrospectively analyzed data from 290 patients with MM (M = 150; F = 140; median age 52 years, range 19-70; stage I = 34, stage II = 75, stage III = 167) reported to the GITMO. At the time of autograft, 20% were in CR, 66% in PR, while the remaining had non-responsive or progressive disease. Median time between diagnosis and transplant was 16 months (1-90). Seventy-two patients (26%) had been planned to receive a double autograft, but this was actually done in only 35 (12%). The conditioning was chemotherapy in 90%. Peripheral blood was the only source of stem cells in 94%, and purging was applied in 10% of cases. For statistical analysis of data, differences between patient subsets were analyzed using the chi-square test, while the Kaplan-Meier method was used to estimate event-free survival (EFS) and survival (OS) probabilities. The Cox model was used for multivariate analysis. RESULTS: Following the autograft, 116 patients (40%) were in CR, 144 (50%) in PR, 24 (8%) did not respond or progressed and 6 (2%) died before response evaluation. Transplant-related mortality occurred in 3%. At a median follow-up of 23 months, 223 (77%) patients are alive, 71 (24%) of them in CR, and 67 (23%) patients have died at a median time of 20 months (0-70). OS and EFS at 6 years are 47% and 28%, respectively, but the EFS curve shows no plateau. In multivariate analysis, age, beta2-microglobulin level and status at transplant emerged as significant prognostic factors for both OS and EFS, while time from diagnosis to transplant showed borderline significance. INTERPRETATION AND CONCLUSIONS: Based on the prognostic factors identified in multivariate analysis, we were able to assess the weight of a single prognostic factor or their combinations on transplant outcome. We also calculated the probability of OS and EFS by the number of factors at the time of autograft. Autologous transplantation is a safe and effective procedure, not only in sensitive patients, but also in resistant cases, provided they are <55 years of age and have low beta2-microglobulin. It should be applied early after the diagnosis of multiple myeloma, following the delivery of brief primary chemotherapy.  (+info)

Beta-glucan, a "specific" biologic response modifier that uses antibodies to target tumors for cytotoxic recognition by leukocyte complement receptor type 3 (CD11b/CD18). (7/2589)

beta-Glucans were identified 36 years ago as a biologic response modifier that stimulated tumor rejection. In vitro studies have shown that beta-glucans bind to a lectin domain within complement receptor type 3 (CR3; known also as Mac-1, CD11b/CD18, or alphaMbeta2-integrin, that functions as an adhesion molecule and a receptor for factor I-cleaved C3b, i.e., iC3b) resulting in the priming of this iC3b receptor for cytotoxicity of iC3b-opsonized target cells. This investigation explored mechanisms of tumor therapy with soluble beta-glucan in mice. Normal mouse sera were shown to contain low levels of Abs reactive with syngeneic or allogeneic tumor lines that activated complement, depositing C3 onto tumors. Implanted tumors became coated with IgM, IgG, and C3, and the absent C3 deposition on tumors in SCID mice was reconstituted with IgM or IgG isolated from normal sera. Therapy of mice with glucan- or mannan-rich soluble polysaccharides exhibiting high affinity for CR3 caused a 57-90% reduction in tumor weight. In young mice with lower levels of tumor-reactive Abs, the effectiveness of beta-glucan was enhanced by administration of a tumor-specific mAb, and in SCID mice, an absent response to beta-glucan was reconstituted with normal IgM or IgG. The requirement for C3 on tumors and CR3 on leukocytes was highlighted by therapy failures in C3- or CR3-deficient mice. Thus, the tumoricidal function of CR3-binding polysaccharides such as beta-glucan in vivo is defined by natural and elicited Abs that direct iC3b deposition onto neoplastic cells, making them targets for circulating leukocytes bearing polysaccharide-primed CR3. Therapy fails when tumors lack iC3b, but can be restored by tumor-specific Abs that deposit iC3b onto the tumors.  (+info)

Sequential biochemical modulation of fluorouracil with folinic acid, N-phosphonacetyl-L-aspartic acid, and interferon alfa-2a in advanced colorectal cancer. (8/2589)

PURPOSE: Several agents have been evaluated for their effect as biochemical modulators of fluorouracil (5-FU) in the treatment of metastatic colorectal carcinoma. In this study, we used folinic acid (FA), N-phosphonacetyl-L-aspartic acid (PALA), and recombinant interferon alfa-2a (IFNalpha-2a) in a sequential order to assess the efficacy of this approach in patients with metastatic colorectal carcinoma. PATIENTS AND METHODS: Forty-four patients with metastatic colorectal carcinoma were enrolled onto the study. The treatment course consisted of three cycles: (cycle 1) FA 20 mg/m(2) followed by 5-FU 425 mg/m(2) on days 1 to 5; (cycle 2) PALA 250 mg/m(2) on days 29, 36, 43, and 50 and 5-FU 2,600 mg/m(2) as a 24-hour infusion on days 30, 37, 44, and 51; and (cycle 3) IFNalpha-2a 9 million units (MU) three times a week for 5 weeks beginning on day 57, with a continuous infusion of 5-FU 750 mg/m(2) on days 57 to 61, and then weekly bolus of 5-FU 750 mg/m(2)/wk on days 71, 78, and 85. Response was determined after cycle 3. RESULTS: All patients had a Zubrod performance status >/= 2, measurable disease, and had received no prior chemotherapy for their metastatic disease. A total of 212 cycles were given. Thirty-six patients were assessable for response. No complete responses were seen. Seven patients had a partial response, eight had stable disease, and 15 had progressive disease. The median duration of response was 25 weeks, and the median survival was 53 weeks. Grade 3 and 4 toxic effects included granulocytopenia, stomatitis, diarrhea, rash, nausea, and fatigue. CONCLUSION: This trial provided no evidence that sequential biochemical modulation of 5-FU in patients with metastatic colorectal carcinoma had any therapeutic advantage over conventional treatment regimens of 5-FU plus FA.  (+info)

Medical Definition:

"Risk factors" are any attribute, characteristic or exposure of an individual that increases the likelihood of developing a disease or injury. They can be divided into modifiable and non-modifiable risk factors. Modifiable risk factors are those that can be changed through lifestyle choices or medical treatment, while non-modifiable risk factors are inherent traits such as age, gender, or genetic predisposition. Examples of modifiable risk factors include smoking, alcohol consumption, physical inactivity, and unhealthy diet, while non-modifiable risk factors include age, sex, and family history. It is important to note that having a risk factor does not guarantee that a person will develop the disease, but rather indicates an increased susceptibility.

Immunologic factors refer to the elements of the immune system that contribute to the body's defense against foreign substances, infectious agents, and cancerous cells. These factors include various types of white blood cells (such as lymphocytes, neutrophils, monocytes, and eosinophils), antibodies, complement proteins, cytokines, and other molecules involved in the immune response.

Immunologic factors can be categorized into two main types: innate immunity and adaptive immunity. Innate immunity is the non-specific defense mechanism that provides immediate protection against pathogens through physical barriers (e.g., skin, mucous membranes), chemical barriers (e.g., stomach acid, enzymes), and inflammatory responses. Adaptive immunity, on the other hand, is a specific defense mechanism that develops over time as the immune system learns to recognize and respond to particular pathogens or antigens.

Abnormalities in immunologic factors can lead to various medical conditions, such as autoimmune disorders, immunodeficiency diseases, and allergies. Therefore, understanding immunologic factors is crucial for diagnosing and treating these conditions.

Wasowska BA (July 2010). "Mechanisms involved in antibody- and complement-mediated allograft rejection". Immunologic Research. ... B-cell activating factor (BAFF) also known as tumor necrosis factor ligand superfamily member 13B and CD257 among other names, ... "Elevated B cell-activating factor of the tumour necrosis factor family in coeliac disease". Scandinavian Journal of ... B-Cell+Activating+Factor at the U.S. National Library of Medicine Medical Subject Headings (MeSH) Human DTL genome location and ...
... is an immunosuppressive drug directed against the Rhesus factor. WHO Drug Information Pelletier JP, Mukhtar F ( ... 2020). "Chapter 16 - Passive Monoclonal and Polyclonal Antibody Therapies". In Maitta RW (ed.). Immunologic Concepts in ...
However, evidence conflicts on whether types of vaccines, manufacturers or factors have been associated with sarcomas. As of ... "An immunologic adjuvant is defined as any substance that acts to accelerate, prolong, or enhance antigen-specific immune ... Sasaki S, Okuda K (2000). "The Use of Conventional Immunologic Adjuvants in DNA Vaccine Preparations". In Lowrie DB, Whalen RG ... Scholia has a profile for immunologic adjuvant (Q967453). Adjuvant therapy Animal research Vaxjo database Archived 2020-05-14 ...
Notkins AL (November 2002). "Immunologic and genetic factors in type 1 diabetes". The Journal of Biological Chemistry. 277 (46 ...
... contains binding sites for transcription factors AP-2, SMAD proteins, SP-1 and elements responsive to c-AMP , which can be ... Immunologic Research. 64 (5-6): 1133-1141. doi:10.1007/s12026-016-8870-2. PMC 5126201. PMID 27665459. Kordaß T, Osen W, ... Transcription Factors and MicroRNAs Regulating CD73/NT5E". Frontiers in Immunology. 9: 813. doi:10.3389/fimmu.2018.00813. PMC ... Eichmüller SB (2018-04-18). "Controlling the Immune Suppressor: Transcription Factors and MicroRNAs Regulating CD73/NT5E". ...
Non-specific immunity results in no immunologic memory. There are mechanical, chemical, and biological factors affecting the ... These factors include the epithelial surfaces forming a physical barrier, fatty acids that inhibit the growth of bacteria, and ...
Approximately 15% of recurrent miscarriages are related to immunologic factors. The presence of anti-thyroid autoantibodies is ... Risk factors are those things that increase the likelihood of having a miscarriage but do not necessarily cause a miscarriage. ... Some risk factors can be minimized by avoiding the following: Smoking Cocaine use Alcohol Poor nutrition Occupational exposure ... Risk factors for miscarriage include being an older parent, previous miscarriage, exposure to tobacco smoke, obesity, diabetes ...
A review of immunologic and microbiologic factors". Postgraduate Medical Journal. 75 (884): 328-31. doi:10.1136/pgmj.75.884.328 ...
P. aeruginosa uses the virulence factor exotoxin A to inactivate eukaryotic elongation factor 2 via ADP-ribosylation in the ... The release of intracellular contents induces an immunologic response in immunocompetent patients. In addition P. aeruginosa ... An important factor found to be associated with antibiotic resistance is the decrease in the virulence capabilities of the ... Pyocyanin is a virulence factor of the bacteria and has been known to cause death in C. elegans by oxidative stress. However, ...
"Human eosinophils produce neurotrophins and secrete nerve growth factor on immunologic stimuli". Blood. 99 (6): 2214-20. doi: ... The protein encoded by this gene, NT-3, is a neurotrophic factor in the NGF (Nerve Growth Factor) family of neurotrophins. It ... Also as mentioned, there are other neurotrophic factors structurally related to NT-3: NGF (for "Nerve Growth Factor") BDNF (for ... NT-3 was the third neurotrophic factor to be characterized, after nerve growth factor (NGF) and BDNF (Brain Derived ...
Voulgarelis, Michael; Skopouli, Fotini N. (2007). "Clinical, immunologic, and molecular factors predicting lymphoma development ... with estrogen being considered one of the biggest factors responsible for sex-immunologic dimorphism. Estrogen deficiency ... Although the numerous factors contributing to the progression of this disease have made discovering the exact origin and cause ... Environmental factors, such as glandular viral infection, could prompt epithelial cells to activate the HLA-independent innate ...
Bouma BN, Vlooswijk RA, Griffin JH (Nov 1983). "Immunologic studies of human coagulation factor XI and its complex with high ... factor XII, factor XI, and factor IX). Factor XIa activates factor IX by selectively cleaving arg-ala and arg-val peptide bonds ... Factor IXa, in turn, forms a complex with Factor VIIIa (FIXa-FVIIIa) and activates factor X. Physiological inhibitors of factor ... "Activation of human blood coagulation factor XI independent of factor XII. Factor XI is activated by thrombin and factor XIa in ...
Even physiological factors such as stress and immunologic status appear to be associated with FP. The leech genus Ozobranchus ... Possible factors include some parasites, bacteria, environmental pollutants, UV-light, changing water temperatures and ... Page-Karjian, A; Norton, TM; Krimer, P; Groner, M; Nelson SE, Jr; Gottdenker, NL (September 2014). "Factors influencing ... The global prevalence of the disease also suggests a multifactorial cause, rather than single factors or agents. ...
... toxic and/or immunologic factors. Examples of medical conditions that can cause neuropathies are diabetes mellitus, chronic ... There are many factors which affect the possible shapes of the perceptual deadband, for example: Rate of change of force ...
The cause of AD is not known, although some evidence indicates genetic, environmental, and immunologic factors. Low humidity, ... Things that commonly make it worse include house dust mite, stress and seasonal factors. Phototherapy may be useful in some ... Trikamjee T, Comberiati P, D'Auria E, Peroni D, Zuccotti GV (2021-01-12). "Nutritional Factors in the Prevention of Atopic ... A loss-of-function mutation of filaggrin causes loss of this lipid matrix and external moisturizing factors, subsequently ...
2004). "Molecular cloning and immunologic characterization of a novel cDNA coding for progesterone-induced blocking factor". J ... Progesterone-induced-blocking factor 1 is a protein that in humans is encoded by the PIBF1 gene. It has been shown to localize ... Szekeres-Bartho J, Varga P, Pejtsik B (1990). "ELISA test for the detection of an immunological blocking factor in human ... Kozma N, Halasz M, Palkovics T, Szekeres-Bartho J (2006). "The progesterone-induced blocking factor modulates the balance of ...
"Immunologic profiles of effector cells and peripheral blood stem cells mobilized with different hematopoietic growth factors". ... The expression of VLA-4 in the plasma membrane is regulated by different growth factors or chemokines depending on the cell ...
Activation and deactivation results from a variety of factors, including cytokines, soluble receptors, arachidonic acid ...
The signs and symptoms of disease are wide-ranging in severity, but can be grouped into vascular, immunologic, and hematologic ... ADA2 has been hypothesized to have multiple functions, including as an enzyme, a growth factor, and an intracellular DNA sensor ... Less is known about the role of ADA2 dysfunction in the immunologic and hematologic aspects of the disease.[citation needed] ... However, the ADA2 protein is similar in structure to the adenosine deaminase growth factors found in other species. ...
The chronic activation of monocytes can lead to multiple metabolic, hematologic and immunologic abnormalities in patients with ... The colony stimulating factor 1 (CSF1), also known as macrophage colony-stimulating factor (M-CSF), is a secreted cytokine ... It is one of the three experimentally described colony-stimulating factors. M-CSF binds to the colony stimulating factor 1 ... Macrophage+Colony-Stimulating+Factor at the U.S. National Library of Medicine Medical Subject Headings (MeSH) Overview of all ...
Immunologic and prognostic factors associated with overall survival employing a poxviral-based PSA vaccine in metastatic ... "Immunologic and prognostic factors associated with overall survival employing a poxviral-based PSA vaccine in metastatic ... with and without granulocyte-macrophage colony-stimulating factor, in patients with carcinoembryonic antigen-expressing ...
Sutnick, A.I., London, W.T., Blumberg, B.S., Gerstley, B.J.S. Susceptibility to leukemia: immunologic factors in Down's ... Canscreen included not only detection, but also cancer prevention and health education, and research in cancer risk factors. In ... Daniel Miller to create Canscreen, the first cancer screening program based on risk factor analysis. ...
The morphology of the tissues, the histology, and immunologic findings are all used in diagnosis of the form of the condition. ... The distinction between the various types of contact dermatitis is based on a number of factors. ...
Genetic factors: Such as Down's syndrome and sickle cell anemia The most notable components of the cell that are targets of ... Metabolic: Hypoxia and Ischemia Chemical Agents Microbial Agents: Virus & Bacteria Immunologic Agents: Allergy and autoimmune ... DNA damage: In human cells, both normal metabolic activities and environmental factors such as ultraviolet light and other ... Amongst other causes, this can be due to physical, chemical, infectious, biological, nutritional or immunological factors. Cell ...
The immunologic function of GM3 in inhibiting proliferation has resulted in its usage in the study of cancer biology and cancer ... GM3 also functions as an inhibitor; it inhibits cell growth, the function of growth factor receptors, and generation of ...
2006). "Increased activity of coagulation factor XII (Hageman factor) causes hereditary angioedema type III". Am. J. Hum. Genet ... Acquired angioedema (AAE) can be immunologic, nonimmunologic, or idiopathic. It is usually caused by allergy and occurs ... In this analysis, it is usually a reduced complement factor C4, rather than the C1-INH deficiency itself, that is detected. The ... It has been linked with mutations in the factor XII gene. Angioedema can be due to antibody formation against C1INH; this is an ...
... is a human monoclonal antibody against the human Rhesus factor. "Proposed International Nonproprietary Names: ... Immunologic Concepts in Transfusion Medicine. Philadelphia: Elsevier. p. 300. doi:10.1016/B978-0-323-67509-3.00016-0. ISBN 978- ...
"Nuclear factor-kappaB-dependent induction of interleukin-8 gene expression by tumor necrosis factor alpha: evidence for an ... "Immunologic profile of excessive body weight". Biomarkers. 16 (3): 243-51. doi:10.3109/1354750X.2010.547948. PMID 21506696. ... IL-8 has also been implied to have a role in colorectal cancer by acting as an autocrine growth factor for colon carcinoma cell ... IL-8 and other inflammatory cytokines form a vicious cycle with the transcription factor NF-κB in cystic fibrosis. NF-κB ...
... immunologic, and environmental factors contribute to case clustering. Host genetic factors play a major role in determining ... It was found that the latent herpesvirus caused an increase in interferon-gamma (IFN-γ) and tumor necrosis factor-alpha (TNF-α ... It is clear that there are also environmental factors to consider. Infections such as rubella and meningitis and low birth ... Further testing is needed, especially in determining the role of GJB2 variants and environmental factors on a population level ...
... and transforming growth factor beta 1 (TGF-beta 1). Another study revealed that geniposide's effect was probably enhanced by ... immunoregulation in immunologic tissues, such as gut-associated lymphoid tissue (GALT). When regulating, the mesenteric lymph ... and the induction of the nuclear translocation of erythroid 2-related factor 2 (NFE2L2). The PI3K/Nrf2 pathway signaling ...
PA, protective antigen; LT, lymphocyte; Ag, antigen; LF, lethal factor; conA, concanavalin A.. †Performed on serum samples ... Immunologic Response of Unvaccinated Workers Exposed to Anthrax, Belgium Pierre Wattiau. , Marc Govaerts, Dimitrios ... Immunologic Response of Unvaccinated Workers Exposed to Anthrax, Belgium. ...
... and rheumatoid factor). Hypocomplementemia was associated with a higher frequency of vasculitis and lymphoma, and cryoglobulins ... Primary Sjögren syndrome in Spain: clinical and immunologic expression in 1010 patients Medicine (Baltimore). 2008 Jul;87(4): ... The subset of patients with anti-Ro/La antibodies had the highest prevalence of most systemic, hematologic, and immunologic ... and a high frequency of immunologic markers (anti-Ro/SS-A and low C4 levels). Patients with disease duration of more than 10 ...
"Immunologic Factors" by people in this website by year, and whether "Immunologic Factors" was a major or minor topic of these ... "Immunologic Factors" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical ... Below are the most recent publications written about "Immunologic Factors" by people in Profiles. ... Below are MeSH descriptors whose meaning is more general than "Immunologic Factors". ...
Immunologic Factors in Preeclampsia. Immunologic factors have long been considered to be key players in preeclampsia. One ... However, immunologic and genetic factors have been proposed. Early hypoxic insult to differentiating cytotrophoblasts has also ... Angiogenic Factors in Preeclampsia. The circulating proangiogenic factors secreted by the placenta include vascular endothelial ... What is the role of immunologic factors in the pathogenesis of preeclampsia? ...
Immunologic factors. Involvement of immunological mechanisms is suggested by the inflammatory process in psoriatic skin lesions ... Environmental factors. The theory of environmental factors playing a role in the etiology of psoriatic arthritis involves a ... Genetic factors play an important role in susceptibility to psoriasis and psoriatic arthritis [15] ; approximately 40% of ... Tumour necrosis factor-alpha polymorphism and the HLA-Cw*0602 allele in psoriatic arthritis. Rheumatology (Oxford). 2002 May. ...
Wasowska BA (July 2010). "Mechanisms involved in antibody- and complement-mediated allograft rejection". Immunologic Research. ... B-cell activating factor (BAFF) also known as tumor necrosis factor ligand superfamily member 13B and CD257 among other names, ... "Elevated B cell-activating factor of the tumour necrosis factor family in coeliac disease". Scandinavian Journal of ... B-Cell+Activating+Factor at the U.S. National Library of Medicine Medical Subject Headings (MeSH) Human DTL genome location and ...
Immunologic Factors / pharmacology* * Lactobacillus / metabolism* * Leukocytes, Mononuclear / immunology * Male * Middle Aged * ...
However, risk factors for post-vaccination fatal COVID-19 are largely unknown. We comprehensively studied three large nursing ... Immunologic resilience and COVID-19 survival advantage. J. Allergy Clin. Immunol. 148, 1176-1191 (2021). ... 3: Immunological and virological risk factors identified in fatal COVID-19 outbreak cases among residents in three nursing ... A retrospective cohort study of risk factors for mortality among nursing homes exposed to COVID-19 in Spain. Nat. Aging 1, 579- ...
... has shown that genetic and immunologic factors that affect the severity of the disease are found in approximately 15% of severe ... healthy people suffer severe COVID-19 by linking incidence to genetic and immunologic factors. These factors can result in ... Influence of genetic and immunologic factors identified in 15% of severe COVID-19 patients ... Influence of genetic and immunologic factors identified in 15% of severe COVID-19 patients *An international study involving ...
Since dialysis of human factor VIII against buffers of low ionic strength yielded two distinct components, and since the factor ... Immunologic studies on human factor VIII (anti-hemophilic factor A, AHF) components produced by low-ionic-strength dialysis BN ... BN Bouma, JA van Mourik, S de Graaf, JM Hordijk-Hos, JJ Sixma; Immunologic studies on human factor VIII (anti-hemophilic factor ... Dialysis of factor VIII against buffers of low ionic strength led, however, to a decrease in factor VIII procoagulant activity ...
Immunologic Causes: One category of immunologic problems that can cause miscarriages are the antiphospholipid antibodies. Blood ... Environmental Factors: The environmental toxins you may be exposed to in the air around you can also result in fetal damage or ... Another category of immunologic causes of miscarriage are those that prevent the womans normal protective response to the ... There are also blood tests that check for protective blocking factors. These are essential to protect the pregnancy from being ...
... are immune factors that are also associated with ARDS in some patients with very severe disease6. All of these factors are ... Immunologic Research (2023). * Pathophysiology of Post-COVID syndromes: a new perspective *Gaber El-Saber Batiha ... Characteristics and prognostic factors of disease severity in patients with COVID-19: the Beijing experience. J. Autoimmun. ... Analysis of factors associated with disease outcomes in hospitalized patients with 2019 novel coronavirus disease. Chin. Med. J ...
Is it related to a detox factor? Is it due to a carb withdrawal? Is there an immunologic reaction? Or is this a result of a ... But this should not be the deciding factor when choosing what to put on your plate. Ideally, you should have the most ...
Immunologic parameters CD4 cell counts [28(104), 24(147) and -40(77): for placebo, 1 and 2 mg, respectively] did not change ... A placebo-controlled, dose-ranging study of a growth hormone releasing factor in HIV-infected patients with abdominal fat ... Insulin-like growth factor-I (IGF-I), glucose, insulin, lipid profile [cholesterol, high-density lipoprotein (HDL), low-density ... Secondary endpoints included change in insulin-like growth factor-I (IGF-I), metabolic, quality of life, and safety parameters. ...
Probably multifactorial: immunologic, genetic, environmental factors. Genetics. *30-40% concordance in identical twins ... CD4+/CD8+ T cells; tumor necrosis factor α (TNF-α); interleukins 1 (IL-1), 6, 8, and 10; and matrix metalloproteases present in ... Rheumatoid factor (RF) and anti-cyclic citrullinated peptide (anti-CCP) antibody are usually negative. HLA-B27 may be positive. ...
... reduction in immunologic function, and higher rates of depression, injury, heart disease, GI disorders, mood disturbances, and ... Risk-factors; Injuries; Heart; Diseases; Cardiovascular-system-disease; Cardiovascular-system-disorders; Cardiovascular-disease ...
Other factors in the abnormal immunologic response are described. Patients with HIE syndrome have elevated levels of ... Diagnostic approach to the hyper-IgE syndromes: immunologic and clinical key findings to differentiate hyper-IgE syndromes from ... Increase in granulocyte-macrophage-colony-stimulating factor secretion and the respiratory burst with decreased L-selectin ... granulocyte-macrophage colony-stimulating factor, which may also explain the decreased chemotaxis and increased oxygen radical ...
Maternal and immunologic and virologic risk factors for infant human immunodeficiency virus type 1 infection: Findings from the ... Risk for perinatal HIV-1 transmission according to maternal immunologic, virologic, and placental factors. JAMA 1993;269:2853-- ... Several risk factors are associated with perinatal HIV transmission. Clinical factors that increase the likelihood of ... Risk factors for perinatal transmission of human immunodeficiency virus type 1 in women treated with zidovudine. N Engl J Med ...
Categories: Immunologic Factors Image Types: Photo, Illustrations, Video, Color, Black&White, PublicDomain, CopyrightRestricted ...
"Immunologic Research. 47 (1-3): 25-44. doi:10.1007/s12026-009-8136-3. PMC 2892186. PMID 20135240.. ... B-cell activating factor (BAFF) also known as tumor necrosis factor ligand superfamily member 13B is a protein that in humans ... B-cell activating factor has been shown to interact with TNFRSF13B,[8][9] TNFSF13,[10] TNFRSF13C,[11][12] and TNFRSF17.[13][14] ... "Elevated B cell-activating factor of the tumour necrosis factor family in coeliac disease". Scandinavian Journal of ...
LP is a T-cell mediated immunologic disease but the responsible antigen remains unidentified. In this paper, we review the ... Clinical Factors. Associated factors and disease conditions seen in LP include but are not limited to stress/anxiety, hepatitis ... G. Zhou, K. Xia, G. Du et al., "Activation of nuclear factor-kappa B correlates with tumor necrosis factor-alpha in oral Lichen ... 4. Etiology and Risk Factors. 4.1. Immunogenetic Factors. LP is a complex disease and thus can be caused or triggered by ...
... immunologic;?Chelating agents;?Drug / Therapeutic Agent;?Immunologic Factors.?Additionally,?it is?white crystalline powder ...
Adding or subtracting immunologic factors profoundly modifies the outcome of hair growth. ... Heritable factors distinguish two types of alopecia areata. Dermatol Clin. 1996 Oct. 14(4):679-89. [QxMD MEDLINE Link]. ... Many factors favor a genetic predisposition for alopecia areata. The frequency of positive family history for alopecia areata ... Adverse prognostic factors include nail abnormalities, atopy, onset at a young age, and severe forms of alopecia areata. ...
B-lymphocytes appear to propagate demyelination and neurodegeneration, most likely by producing soluble neurotoxic factors. Key ... Hohlfeld R. Immunologic factors in primary progressive multiple sclerosis. Mult Scler. (2004) 10:S16-22. doi: 10.1191/ ... More likely, soluble factors, produced by the inflammatory cells, may exert tissue damage either directly or indirectly by the ... In this line some data suggest that B-cells within the central nervous system of MS patients produce factors that can trigger ...
... and virulence factors; resistance to antimicrobial agents; taxonomy; epidemiology and phenotypic, immunologic and molecular ... Impact factor. The Impact Factor measures the average number of citations received in a particular year by papers published in ...
Target-Derived Neurotrophic Factor Deprivation Puts Retinal Ganglion Cells on Death Row: Cold Hard Evidence and Caveats by ... Cytokine-induced killer cells (CIKs) are considered to be major cytotoxic immunologic effector cells. Usually cancer cells are ... Genetic Factors of Cerebral Small Vessel Disease and Their Potential Clinical Outcome by Vo Van Giau ... Such a permanent exposure of the entrance to the active site may be a key factor for improved turnover rate of the cold adapted ...
... epidemiologic factors associated with transmission of HBV. The detection of anti-HBs is indicative of a prior immunologic ...
Immunologic Factors. Physiological Effects of Drugs. Angiogenesis Inhibitors. Angiogenesis Modulating Agents. Growth Substances ...
  • The international collaborative study COVID Human Genetic Effort (COVIDHGE), in which the Hospital Complex of Navarre (CHN) and the Navarrabiomed Clinical Trials Platform took part, has shown that genetic and immunologic factors that affect the severity of the disease are found in approximately 15% of severe cases of COVID-19. (navarrabiomed.es)
  • Abnormality in this molecule is due to genetic or immunologic factors that prevent the body's cells from defending themselves against the coronavirus, which may leave the patient in a severe clinical condition. (navarrabiomed.es)
  • The results recently published in two articles in the journal Science partially solve the mystery of why some young, healthy people suffer severe COVID-19 by linking incidence to genetic and immunologic factors. (navarrabiomed.es)
  • These findings will make it possible to more accurately select candidates for the different clinical trials in progress to assess the utility of treatment with interferon or blockers of these antibodies, aimed at counteracting the consequences of these genetic and immunologic factors involved in some severe forms of COVID-19", said Dr. Aguilera. (navarrabiomed.es)
  • As this frightening pandemic has spread rapidly throughout the world, the sometimes contradictory reports of its manifestations should be understood in the context of the heterogeneous populations that have been infected, and the immense spectrum of genetic predispositions, coexisting risk factors and pre-existing medications that can hinder cohesive understanding. (nature.com)
  • The exact cause of pediatric Crohn's disease is not fully understood, but this is thought to develop because of multiple different factors occurring together including genetic, immunologic and environmental triggers. (rarediseases.org)
  • Etiologies include immunologic and genetic factors. (definitions.net)
  • however, it is thought to be the result of a combination of genetic and immunologic factors. (psychiatrist.com)
  • What initiates the autoimmune reaction in Crohn's disease is unclear, but genetic and environmental factors play roles. (hdkino.org)
  • Role of factor XIII in fibrin clot formation and effects of genetic polymorphisms. (medscape.com)
  • Environmental, genetic, and immunologic factors appear to play a role. (medscape.com)
  • Determine the immunologic and virologic effects of IL-12 in these patients. (knowcancer.com)
  • BAFF is the natural ligand of three nonconventional tumor necrosis factor receptors named BAFF-R (BR3), TACI (transmembrane activator and calcium modulator and cyclophilin ligand interactor), and BCMA (B-cell maturation antigen), all of which have differing binding affinities for it. (wikipedia.org)
  • [4] BAFF is the natural ligand of three unusual tumor necrosis factor receptors named BAFF-R (BR3), TACI (transmembrane activator and calcium modulator and cyclophilin ligand interactor), and BCMA (B-cell maturation antigen), all of which have differing binding affinities for it. (wikidoc.org)
  • Drugs or contact allergens can cause lichenoid reactions as the main differential diagnosis of LP. LP is a T-cell mediated immunologic disease but the responsible antigen remains unidentified. (hindawi.com)
  • The detection of anti-HBs is indicative of a prior immunologic exposure to the antigen or vaccine. (cdc.gov)
  • Anaphylaxis is a systemic, immediate hypersensitivity reaction mediated by factors released from interactions between immunoglobulin E (IgE) and mast cells that produce an antigen-antibody reaction. (cancernetwork.com)
  • Factor XIIIa and factor XIIIb antigen levels can be quantified by means of enzyme-linked immunosorbent assay (ELISA). (medscape.com)
  • B-cell activating factor (BAFF) also known as tumor necrosis factor ligand superfamily member 13B and CD257 among other names, is a protein that in humans is encoded by the TNFSF13B gene. (wikipedia.org)
  • Detection in the 1970s of a related orthopoxvirus that causes monkeypox, a similar but milder illness in humans that can be fatal in up to 10 percent of patients, raised concerns that this virus may replace the ecologic and immunologic niche created by the eradication of smallpox. (cdc.gov)
  • Borrelia peptidoglycan interacting Protein (BpiP) contributes to the fitness of Borrelia burgdorferi against host-derived factors and influences virulence in mouse models of Lyme disease. (ouhsc.edu)
  • epidemiology and phenotypic, immunologic and molecular diagnostic methods. (elsevier.es)
  • The subset of patients with anti-Ro/La antibodies had the highest prevalence of most systemic, hematologic, and immunologic alterations (higher frequency of Raynaud phenomenon, altered parotid scintigraphy, positive salivary gland biopsy, peripheral neuropathy, thrombocytopenia, and rheumatoid factor). (nih.gov)
  • Specific antibodies to the low ionic strength components inhibited factor VIII activity in normal plasma, but the residual factor VIII was higher than that after inhibition with antibodies against intact factor VIII. (ashpublications.org)
  • Both antibodies interfered with von Willebrand factor activity. (ashpublications.org)
  • One category of immunologic problems that can cause miscarriages are the antiphospholipid antibodies . (resolve.org)
  • Is there an immunologic reaction? (harvard.edu)
  • The explant-mixed epidermal lymphocyte reaction system gave consistent, reproducible results and may prove useful for the allocation of an immune protection factor to all sunscreens. (bentham.co.uk)
  • The 2 methods used to measure the enzymatic activity of factor XIII include measurement of synthetic amine incorporation into a fibrin clot, and measurement of ammonium ion release during the transglutaminase reaction. (medscape.com)
  • We utilize a combination of physiologic mouse models, human tissues, advanced immunologic tools, and cutting-edge quantitative imaging. (seattlechildrens.org)
  • Hypocomplementemia was associated with a higher frequency of vasculitis and lymphoma, and cryoglobulins with a higher frequency of parotid enlargement, vasculitis, and leukopenia.Epidemiologic, clinical, and analytical features have a significant impact on the clinical presentation of primary SS, influencing the results of the main diagnostic tests, the prevalence and diversity of extraglandular involvement, and the frequency of the main immunologic markers. (nih.gov)
  • Better demand for diagnostic procedures, policy coverage, high-level of awareness, and others are some of the significant factors that can inspire the market growth. (medgadget.com)
  • Exposure of skin to sunlight also depends on multiple lifestyle factors (eg, clothing, occupation, recreational activities). (msdmanuals.com)
  • Methods In this study we describe treatment interruption patterns over time among clients who interrupt and subsequently resume HAART, and those who are continuously engaged in treatment, and determine clinical factors associated with loss to engagement.An observational, longitudinal, retrospective cohort design was engaged, using secondary treatment program data. (researchgate.net)
  • Delayed umbilical bleeding--a presenting feature for factor XIII deficiency: clinical features, genetics, and management. (medscape.com)
  • BAFF is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. (wikipedia.org)
  • Nerve cells do so by releasing neuromediators such as substance P (SP), which acts on both the vascular bed to cause vasodilation and increase permeability, and on skin cells to promote the release of pro-inflammatory cytokines including some interleukins (IL-1 and IL-8) and tumor necrosis factor-alpha (TNF-α). (cosmeticsandtoiletries.com)
  • In so doing, we have uncovered a dominant factor (TGFβ) that limits immunity within the granuloma, gained insight into aspects of the early events of Mycobacterium tuberculosis (Mtb) infection, and characterized organizational features of tuberculous granulomas. (seattlechildrens.org)
  • Rheumatoid factor (RF) and anti-cyclic citrullinated peptide (anti-CCP) antibody are usually negative. (unboundmedicine.com)
  • Factors like brain-gut axis interactions, immunologic disturbances, oxidative stress, and vagus nerve dysfunction can cause inflammatory bowel disease and mental disorders. (psychiatrist.com)
  • A quantitative assay is required to confirm the diagnosis of factor XIII deficiency. (medscape.com)
  • Immunologic Factors" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (ouhsc.edu)
  • We conducted a population-based, frequency-matched case-control study in Sicily to further investigate the reported inverse relationship between smoking and classical Kaposi sarcoma and to identify other factors associated with altered risk. (aacrjournals.org)
  • Identify key concepts of the immunologic and neuropathologic disease processes associated with multiple sclerosis. (hcplive.com)
  • Dialysis of factor VIII against buffers of low ionic strength led, however, to a decrease in factor VIII procoagulant activity and the reduction of the correcting activities, which suggested that the intact aggregate was required for procoagulant activity and for von Willebrand factor activity. (ashpublications.org)
  • Since dialysis of human factor VIII against buffers of low ionic strength yielded two distinct components, and since the factor VIII fraction isolated from normal plasma showed von Willebrand factor activity as defined by the corrective effect on abnormal platelet retention and ristocetin aggregation in von Willebrand's disease, the present studies were performed to determine if the correcting activities could be attributed to one or both of the components. (ashpublications.org)
  • Determine the effect of IL-12 on angiogenic factors, including basic fibroblast growth factor, vascular endothelial growth factor, and interferon-inducible protein 10 in these patients. (knowcancer.com)
  • Immunologic and inflammatory diseases contribute to the progression of the disease. (emedicinehealth.com)
  • Cartilage destruction is a result of several mechanical and biological factors rather than a single entity. (emedicinehealth.com)
  • The identified transcription factors influence both the global and specific gene expression of the BCLs and have possible implications for diagnosis and treat- ment. (lu.se)
  • Young-onset patients had a low degree of sicca involvement (xerostomia and parotid enlargement) and a high frequency of immunologic markers (anti-Ro/SS-A and low C4 levels). (nih.gov)
  • Objective: To investigate the effects of TH9507, a novel growth hormone releasing factor, on abdominal fat accumulation, metabolic and safety parameters in HIV-infected patients with central fat accumulation. (natap.org)
  • Clarify the appropriate use of immunologic (CD4 count) monitoring in the care of patients with HIV. (hivguidelines.org)
  • Problems relating to the laboratory diagnosis of factor XIII deficiency: a UK NEQAS study. (medscape.com)
  • Ichinose A. Physiopathology and regulation of factor XIII. (medscape.com)
  • Precipitating factors include herpes simplex virus (HSV), Epstein-Barr virus (EBV), and histoplasmosis. (medscape.com)
  • It is believed that reasons for these racial disparities may include socioeconomic factors, but the true causes are not fully understood. (managedhealthcareexecutive.com)
  • Ichinose A, Asahina T, Kobayashi T. Congenital blood coagulation factor XIII deficiency and perinatal management. (medscape.com)
  • B-lymphocytes may propagate demyelination and neurodegeneration, most likely by producing soluble neurotoxic factors. (frontiersin.org)
  • These factors can result in admission to the ICU and even death. (navarrabiomed.es)
  • At the end of follow-up, the hazard of unfavorable treatment outcome (dead, lost, stopped HAART) for clients who restarted treatment at months 6, 12, 18 and 24 was higher by a factor of 1.9, 2.4, 2.6 and 2.4, as compared to those who never discontinued treatment at those times. (researchgate.net)
  • Testing for anti-HBs can be useful for: a) evaluating the recovery and prognosis of patents infected with HBV, b) screening for potential vaccine recipients, and c) epidemiologic factors associated with transmission of HBV. (cdc.gov)
  • However, risk factors for post-vaccination fatal COVID-19 are largely unknown. (nature.com)
  • In fact, recent or recurrent herpes has been reported as the principle risk factor for erythema multiforme. (medscape.com)
  • And those in purple are recommended for adults with additional risk factors or another indication. (cdc.gov)
  • The two low ionic strength components were identified by the use of a rabbit antiserum against factor VIII, and could be distinguished on the basis of specific antigenic structures. (ashpublications.org)
  • Results from standard hemostatic screening tests such as activated partial thromboplastin time (aPTT) and international normalized ratio (INR) assessments are normal in factor XIII (FXIII) deficiency. (medscape.com)
  • The role of a missing intermediate factor that inflammation modifies differently in BD and UC is another possibility. (psychiatrist.com)
  • Ecologic factors, including changes in the environment and agent reservoirs, also might have contributed to changes in the incidence of monkeypox. (cdc.gov)
  • Additional studies have revealed a broad anti-inflammatory effect of α-MSH apparently mediated by a modulation of nuclear factor κ-β activity (NF-κβ). (cosmeticsandtoiletries.com)
  • Several studies have suggested a lack of correlation between sunscreen sun protection factor and protection of skin immune system, potentially allowing greater damage to the skin by removing the natural protective erythemal response to sun exposure. (bentham.co.uk)
  • Dialysis of factor VIII at low ionic strength led to a decrease in antigenic determinants closely related to factor VIII function. (ashpublications.org)
  • Secondary endpoints included change in insulin-like growth factor-I (IGF-I), metabolic, quality of life, and safety parameters. (natap.org)
  • B-cell activating factor has been shown to interact with TNFRSF13B, TNFSF13, TNFRSF13C, and TNFRSF17. (wikipedia.org)
  • This graph shows the total number of publications written about "Immunologic Factors" by people in this website by year, and whether "Immunologic Factors" was a major or minor topic of these publications. (ouhsc.edu)
  • The purpose of this study was to develop an in vitro system for testing the immunologic protection afforded by sunscreens in human skin. (bentham.co.uk)