Immunoglobulin idiotypes. Medical search

Unique genetically-controlled determinants present on ANTIBODIES whose specificity is limited to a single group of proteins (e.g., another antibody molecule or an individual myeloma protein). The idiotype appears to represent the antigenicity of the antigen-binding site of the antibody and to be genetically codetermined with it. The idiotypic determinants have been precisely located to the IMMUNOGLOBULIN VARIABLE REGION of both immunoglobin polypeptide chains.

Multi-subunit proteins which function in IMMUNITY. They are produced by B LYMPHOCYTES from the IMMUNOGLOBULIN GENES. They are comprised of two heavy (IMMUNOGLOBULIN HEAVY CHAINS) and two light chains (IMMUNOGLOBULIN LIGHT CHAINS) with additional ancillary polypeptide chains depending on their isoforms. The variety of isoforms include monomeric or polymeric forms, and transmembrane forms (B-CELL ANTIGEN RECEPTORS) or secreted forms (ANTIBODIES). They are divided by the amino acid sequence of their heavy chains into five classes (IMMUNOGLOBULIN A; IMMUNOGLOBULIN D; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M) and various subclasses.

The major immunoglobulin isotype class in normal human serum. There are several isotype subclasses of IgG, for example, IgG1, IgG2A, and IgG2B.

A class of immunoglobulin bearing mu chains (IMMUNOGLOBULIN MU-CHAINS). IgM can fix COMPLEMENT. The name comes from its high molecular weight and originally being called a macroglobulin.

Represents 15-20% of the human serum immunoglobulins, mostly as the 4-chain polymer in humans or dimer in other mammals. Secretory IgA (IMMUNOGLOBULIN A, SECRETORY) is the main immunoglobulin in secretions.

Antibodies which react with the individual structural determinants (idiotopes) on the variable region of other antibodies.

Abnormal immunoglobulins characteristic of MULTIPLE MYELOMA.

The largest of polypeptide chains comprising immunoglobulins. They contain 450 to 600 amino acid residues per chain, and have molecular weights of 51-72 kDa.

Serological reactions in which an antiserum against one antigen reacts with a non-identical but closely related antigen.

Polypeptide chains, consisting of 211 to 217 amino acid residues and having a molecular weight of approximately 22 kDa. There are two major types of light chains, kappa and lambda. Two Ig light chains and two Ig heavy chains (IMMUNOGLOBULIN HEAVY CHAINS) make one immunoglobulin molecule.

That region of the immunoglobulin molecule that varies in its amino acid sequence and composition, and comprises the binding site for a specific antigen. It is located at the N-terminus of the Fab fragment of the immunoglobulin. It includes hypervariable regions (COMPLEMENTARITY DETERMINING REGIONS) and framework regions.

Genes encoding the different subunits of the IMMUNOGLOBULINS, for example the IMMUNOGLOBULIN LIGHT CHAIN GENES and the IMMUNOGLOBULIN HEAVY CHAIN GENES. The heavy and light immunoglobulin genes are present as gene segments in the germline cells. The completed genes are created when the segments are shuffled and assembled (B-LYMPHOCYTE GENE REARRANGEMENT) during B-LYMPHOCYTE maturation. The gene segments of the human light and heavy chain germline genes are symbolized V (variable), J (joining) and C (constant). The heavy chain germline genes have an additional segment D (diversity).

The property of antibodies which enables them to react with some ANTIGENIC DETERMINANTS and not with others. Specificity is dependent on chemical composition, physical forces, and molecular structure at the binding site.

One of the types of light chains of the immunoglobulins with a molecular weight of approximately 22 kDa.

Immunoglobulin preparations used in intravenous infusion, containing primarily IMMUNOGLOBULIN G. They are used to treat a variety of diseases associated with decreased or abnormal immunoglobulin levels including pediatric AIDS; primary HYPERGAMMAGLOBULINEMIA; SCID; CYTOMEGALOVIRUS infections in transplant recipients, LYMPHOCYTIC LEUKEMIA, CHRONIC; Kawasaki syndrome, infection in neonates, and IDIOPATHIC THROMBOCYTOPENIC PURPURA.

Local surface sites on antibodies which react with antigen determinant sites on antigens (EPITOPES.) They are formed from parts of the variable regions of FAB FRAGMENTS.

A form of cutaneous tuberculosis. It is seen predominantly in women and typically involves the NASAL MUCOSA; BUCCAL MUCOSA; and conjunctival mucosa.

Allelic variants of the immunoglobulin light chains (IMMUNOGLOBULIN LIGHT CHAINS) or heavy chains (IMMUNOGLOBULIN HEAVY CHAINS) encoded by ALLELES of IMMUNOGLOBULIN GENES.

Sites on an antigen that interact with specific antibodies.

An immunoglobulin associated with MAST CELLS. Overexpression has been associated with allergic hypersensitivity (HYPERSENSITIVITY, IMMEDIATE).

Lymphoid cells concerned with humoral immunity. They are short-lived cells resembling bursa-derived lymphocytes of birds in their production of immunoglobulin upon appropriate stimulation.

The principle immunoglobulin in exocrine secretions such as milk, respiratory and intestinal mucin, saliva and tears. The complete molecule (around 400 kD) is composed of two four-chain units of IMMUNOGLOBULIN A, one SECRETORY COMPONENT and one J chain (IMMUNOGLOBULIN J-CHAINS).

Antibodies produced by a single clone of cells.

Autoantibodies directed against various nuclear antigens including DNA, RNA, histones, acidic nuclear proteins, or complexes of these molecular elements. Antinuclear antibodies are found in systemic autoimmune diseases including systemic lupus erythematosus, Sjogren's syndrome, scleroderma, polymyositis, and mixed connective tissue disease.

The class of heavy chains found in IMMUNOGLOBULIN M. They have a molecular weight of approximately 72 kDa and they contain about 57 amino acid residues arranged in five domains and have more oligosaccharide branches and a higher carbohydrate content than the heavy chains of IMMUNOGLOBULIN G.

Univalent antigen-binding fragments composed of one entire IMMUNOGLOBULIN LIGHT CHAIN and the amino terminal end of one of the IMMUNOGLOBULIN HEAVY CHAINS from the hinge region, linked to each other by disulfide bonds. Fab contains the IMMUNOGLOBULIN VARIABLE REGIONS, which are part of the antigen-binding site, and the first IMMUNOGLOBULIN CONSTANT REGIONS. This fragment can be obtained by digestion of immunoglobulins with the proteolytic enzyme PAPAIN.

Antibodies that react with self-antigens (AUTOANTIGENS) of the organism that produced them.

Antibodies found in adult RHEUMATOID ARTHRITIS patients that are directed against GAMMA-CHAIN IMMUNOGLOBULINS.

Any discrete, presumably solitary, mass of neoplastic PLASMA CELLS either in BONE MARROW or various extramedullary sites.

The classes of immunoglobulins found in any species of animal. In man there are nine classes that migrate in five different groups in electrophoresis; they each consist of two light and two heavy protein chains, and each group has distinguishing structural and functional properties.

One of the types of light chain subunits of the immunoglobulins with a molecular weight of approximately 22 kDa.

The production of ANTIBODIES by proliferating and differentiated B-LYMPHOCYTES under stimulation by ANTIGENS.

An immunoglobulin which accounts for less than 1% of plasma immunoglobulin. It is found on the membrane of many circulating B LYMPHOCYTES.

The domains of the immunoglobulin molecules that are invariable in their amino acid sequence within any class or subclass of immunoglobulin. They confer biological as well as structural functions to immunoglobulins. One each on both the light chains and the heavy chains comprises the C-terminus half of the IMMUNOGLOBULIN FAB FRAGMENT and two or three of them make up the rest of the heavy chains (all of the IMMUNOGLOBULIN FC FRAGMENT)

Crystallizable fragments composed of the carboxy-terminal halves of both IMMUNOGLOBULIN HEAVY CHAINS linked to each other by disulfide bonds. Fc fragments contain the carboxy-terminal parts of the heavy chain constant regions that are responsible for the effector functions of an immunoglobulin (COMPLEMENT fixation, binding to the cell membrane via FC RECEPTORS, and placental transport). This fragment can be obtained by digestion of immunoglobulins with the proteolytic enzyme PAPAIN.

Cells artificially created by fusion of activated lymphocytes with neoplastic cells. The resulting hybrid cells are cloned and produce pure MONOCLONAL ANTIBODIES or T-cell products, identical to those produced by the immunologically competent parent cell.

The processes triggered by interactions of ANTIBODIES with their ANTIGENS.

Small antigenic determinants capable of eliciting an immune response only when coupled to a carrier. Haptens bind to antibodies but by themselves cannot elicit an antibody response.

Calcium and magnesium salts used therapeutically in hepatobiliary dysfunction.

An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.

Serum that contains antibodies. It is obtained from an animal that has been immunized either by ANTIGEN injection or infection with microorganisms containing the antigen.

Benzene derivatives which are substituted with three nitro groups in any position.

Gene rearrangement of the B-lymphocyte which results in a substitution in the type of heavy-chain constant region that is expressed. This allows the effector response to change while the antigen binding specificity (variable region) remains the same. The majority of class switching occurs by a DNA recombination event but it also can take place at the level of RNA processing.

The complex formed by the binding of antigen and antibody molecules. The deposition of large antigen-antibody complexes leading to tissue damage causes IMMUNE COMPLEX DISEASES.

Heavy chains of IMMUNOGLOBULIN G having a molecular weight of approximately 51 kDa. They contain about 450 amino acid residues arranged in four domains and an oligosaccharide component covalently bound to the Fc fragment constant region. The gamma heavy chain subclasses (for example, gamma 1, gamma 2a, and gamma 2b) of the IMMUNOGLOBULIN G isotype subclasses (IgG1, IgG2A, and IgG2B) resemble each other more closely than the heavy chains of the other IMMUNOGLOBULIN ISOTYPES.

A 15 kD "joining" peptide that forms one of the linkages between monomers of IMMUNOGLOBULIN A or IMMUNOGLOBULIN M in the formation of polymeric immunoglobulins. There is one J chain per one IgA dimer or one IgM pentamer. It is also involved in binding the polymeric immunoglobulins to POLYMERIC IMMUNOGLOBULIN RECEPTOR which is necessary for their transcytosis to the lumen. It is distinguished from the IMMUNOGLOBULIN JOINING REGION which is part of the IMMUNOGLOBULIN VARIABLE REGION of the immunoglobulin light and heavy chains.

The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.

Partial immunoglobulin molecules resulting from selective cleavage by proteolytic enzymes or generated through PROTEIN ENGINEERING techniques.

A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys, and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow.

Immunoglobulin molecules having a specific amino acid sequence by virtue of which they interact only with the ANTIGEN (or a very similar shape) that induced their synthesis in cells of the lymphoid series (especially PLASMA CELLS).

Deliberate stimulation of the host's immune response. ACTIVE IMMUNIZATION involves administration of ANTIGENS or IMMUNOLOGIC ADJUVANTS. PASSIVE IMMUNIZATION involves administration of IMMUNE SERA or LYMPHOCYTES or their extracts (e.g., transfer factor, immune RNA) or transplantation of immunocompetent cell producing tissue (thymus or bone marrow).

Specialized Fc receptors (RECEPTORS, FC) for polymeric immunoglobulins, which mediate transcytosis of polymeric IMMUNOGLOBULIN A and IMMUNOGLOBULIN M into external secretions. They are found on the surfaces of epithelial cells and hepatocytes. After binding to IMMUNOGLOBULIN A, the receptor-ligand complex undergoes endocytosis, transport by vesicle, and secretion into the lumen by exocytosis. Before release, the part of the receptor (SECRETORY COMPONENT) that is bound to IMMUNOGLOBULIN A is proteolytically cleaved from its transmembrane tail. (From Rosen et al., The Dictionary of Immunology, 1989)

Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations, or by parent x offspring matings carried out with certain restrictions. All animals within an inbred strain trace back to a common ancestor in the twentieth generation.

Cells of the lymphoid series that can react with antigen to produce specific cell products called antibodies. Various cell subpopulations, often B-lymphocytes, can be defined, based on the different classes of immunoglobulins that they synthesize.

A segment of the immunoglobulin heavy chains, encoded by the IMMUNOGLOBULIN HEAVY CHAIN GENES in the J segment where, during the maturation of B-LYMPHOCYTES; the gene segment for the variable region upstream is joined to a constant region gene segment downstream. The exact position of joining of the two gene segments is variable and contributes to ANTIBODY DIVERSITY. It is distinguished from the IMMUNOGLOBULIN J CHAINS; a separate polypeptide that serves as a linkage piece in polymeric IGA or IGM.

Immunoglobulins produced in a response to BACTERIAL ANTIGENS.

An encapsulated lymphatic organ through which venous blood filters.

Serologic tests in which a known quantity of antigen is added to the serum prior to the addition of a red cell suspension. Reaction result is expressed as the smallest amount of antigen which causes complete inhibition of hemagglutination.

A chronic form of glomerulonephritis characterized by deposits of predominantly IMMUNOGLOBULIN A in the mesangial area (GLOMERULAR MESANGIUM). Deposits of COMPLEMENT C3 and IMMUNOGLOBULIN G are also often found. Clinical features may progress from asymptomatic HEMATURIA to END-STAGE KIDNEY DISEASE.

Lymphocytes responsible for cell-mediated immunity. Two types have been identified - cytotoxic (T-LYMPHOCYTES, CYTOTOXIC) and helper T-lymphocytes (T-LYMPHOCYTES, HELPER-INDUCER). They are formed when lymphocytes circulate through the THYMUS GLAND and differentiate to thymocytes. When exposed to an antigen, they divide rapidly and produce large numbers of new T cells sensitized to that antigen.

IMMUNOGLOBULINS on the surface of B-LYMPHOCYTES. Their MESSENGER RNA contains an EXON with a membrane spanning sequence, producing immunoglobulins in the form of type I transmembrane proteins as opposed to secreted immunoglobulins (ANTIBODIES) which do not contain the membrane spanning segment.

The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.

A specific immune response elicited by a specific dose of an immunologically active substance or cell in an organism, tissue, or cell.

Genes and gene segments encoding the IMMUNOGLOBULIN HEAVY CHAINS. Gene segments of the heavy chain genes are symbolized V (variable), D (diversity), J (joining), and C (constant).

A programmed mutation process whereby changes are introduced to the nucleotide sequence of immunoglobulin gene DNA during development.

A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine).

The class of heavy chains found in IMMUNOGLOBULIN D. They have a molecular weight of approximately 64 kDa and they contain about 500 amino acid residues arranged in four domains and an oligosaccharide component covalently bound to the Fc fragment constant region.

A site located in the INTRONS at the 5' end of each constant region segment of a immunoglobulin heavy-chain gene where recombination (or rearrangement) occur during IMMUNOGLOBULIN CLASS SWITCHING. Ig switch regions are found on genes encoding all five classes (IMMUNOGLOBULIN ISOTYPES) of IMMUNOGLOBULIN HEAVY CHAINS.

The class of heavy chains found in IMMUNOGLOBULIN A. They have a molecular weight of approximately 58 kDa and contain about 470 amino acid residues arranged in four domains and an oligosaccharide component bound covalently to their Fc fragment constant region.

A group of glucose polymers made by certain bacteria. Dextrans are used therapeutically as plasma volume expanders and anticoagulants. They are also commonly used in biological experimentation and in industry for a wide variety of purposes.

Serum globulins that migrate to the gamma region (most positively charged) upon ELECTROPHORESIS. At one time, gamma-globulins came to be used as a synonym for immunoglobulins since most immunoglobulins are gamma globulins and conversely most gamma globulins are immunoglobulins. But since some immunoglobulins exhibit an alpha or beta electrophoretic mobility, that usage is in decline.

Immunoglobulins produced in response to VIRAL ANTIGENS.

The interaction of two or more substrates or ligands with the same binding site. The displacement of one by the other is used in quantitative and selective affinity measurements.

Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.

Endogenous tissue constituents that have the ability to interact with AUTOANTIBODIES and cause an immune response.

The extracellular moiety of the POLYMERIC IMMUNOGLOBULIN RECEPTOR found alone or complexed with IGA or IGM, in a variety of external secretions (tears, bile, colostrum.) Secretory component is derived by proteolytic cleavage of the receptor during transcytosis. When immunoglobulins IgA and IgM are bound to the receptor, during their transcytosis secretory component becomes covalently attached to them generating SECRETORY IMMUNOGLOBULIN A or secretory IMMUNOGLOBULIN M.

Serum albumin from cows, commonly used in in vitro biological studies. (From Stedman, 25th ed)

An immunologic deficiency state characterized by an extremely low level of generally all classes of gamma-globulin in the blood.

Genetic loci in the vertebrate major histocompatibility complex that encode polymorphic products which control the immune response to specific antigens. The genes are found in the HLA-D region in humans and in the I region in mice.

The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.

Allelic variants of the gamma-immunoglobulin heavy chain (IMMUNOGLOBULIN GAMMA-CHAINS) encoded by ALLELES of IMMUNOGLOBULIN HEAVY CHAIN GENES.

The thin, yellow, serous fluid secreted by the mammary glands during pregnancy and immediately postpartum before lactation begins. It consists of immunologically active substances, white blood cells, water, protein, fat, and carbohydrates.

Molecules found on the surface of some, but not all, B-lymphocytes, T-lymphocytes, and macrophages, which recognize and combine with the Fc (crystallizable) portion of immunoglobulin molecules.

Transfer of immunity from immunized to non-immune host by administration of serum antibodies, or transplantation of lymphocytes (ADOPTIVE TRANSFER).

Idiotype vaccination using dendritic cells after autologous peripheral blood stem cell transplantation for multiple myeloma--a feasibility study. (1/883)

The idiotype (Id) determinant on the multiple myeloma (MM) protein can be regarded as a tumor-specific marker. Immunotherapy directed at the MM Id may stem the progression of this disease. We report here on the first 12 MM patients treated at our institution with high-dose therapy and peripheral blood stem cell transplantation (PBSCT) followed by Id immunizations. MM patients received PBSCT to eradicate the majority of the disease. PBSCT produced a complete response in 2 patients, a partial response in 9 patients and stable disease in 1 patient. Three to 7 months after high-dose therapy, patients received a series of monthly immunizations that consisted of two intravenous infusions of Id-pulsed autologous dendritic cells (DC) followed by five subcutaneous boosts of Id/keyhole limpet hemocyanin (KLH) administered with adjuvant. Between 1 and 11 x 10(6) DC were obtained by leukapheresis in all patients even after PBSCT. The administration of Id-pulsed DC and Id/KLH vaccines were well tolerated with patients experiencing only minor and transient side effects. Two of 12 patients developed an Id-specific, cellular proliferative immune response and one of three patients studied developed a transient but Id-specific cytotoxic T-cell (CTL) response. Eleven of the 12 patients generated strong KLH-specific cellular proliferative immune responses showing the patients' immunocompetence at the time of vaccination. The two patients who developed a cellular Id-specific immune response remain in complete remission. Of the 12 treated patients, 9 are currently alive after autologous transplantation with a minimum follow-up of 16 months, 2 patients died because of recurrent MM and 1 patient succumbed to acute leukemia. These studies show that patients make strong anti-KLH responses despite recent high-dose therapy and that DC-based Id vaccination is feasible after PBSCT and can induce Id-specific T-cell responses. Further vaccine development is necessary to increase the proportion of patients that make Id-specific immune responses. The clinical benefits of Id vaccination in MM remain to be determined. (+info)

DNA vaccination against the idiotype of a murine B cell lymphoma: mechanism of tumor protection. (2/883)

Several studies have shown that immunization with DNA, which encodes the idiotypic determinants of a B cell lymphoma, generates tumor-specific immunity. Although induction of antiidiotypic Abs has correlated with tumor protection, the effector mechanisms that contribute to tumor protection have not been clearly identified. This study evaluated the tumor protective effects of humoral and cellular immune mechanisms recruited by idiotype-directed DNA vaccines in the 38C13 murine B cell lymphoma model. Antiidiotypic Abs induced by DNA vaccination supported in vitro complement-mediated cytotoxicity of tumor cells, and simultaneous transfer of tumor cells and hyperimmune sera protected naive animals against tumor growth. However, in vitro stimulation of immune splenocytes with tumor cells failed to induce idiotype-specific cytotoxicity, and following vaccination, depletion of CD4 or CD8 T cell subsets did not compromise protection. Furthermore, protection of naive recipients against tumor challenge could not be demonstrated either by a Winn assay approach or by adoptive transfer of spleen and lymph node cells. Thus, in this experimental model, current evidence suggests that the tumor-protective effects of DNA vaccination can be largely attributed to idiotype-specific humoral immunity. (+info)

Regulation of NOD mouse autoimmune diabetes by T cells that recognize a TCR CDR3 peptide. (3/883)

NOD mice spontaneously develop type I diabetes resulting from autoimmune destruction of their insulin-producing beta cells. Among the self-antigens targeted by NOD autoimmune T cells is a peptide, p277, from the sequence of the 60 kDa heat shock protein (hsp60). Common to the anti-p277 T cell populations of NOD mice is an idiotope, C9, that spans the CDR3 region of the C9 TCR. We now report: (i) that the C9 idiotope peptide can be presented directly to anti-C9 anti-idiotypic T cells by C9 T cells, (ii) that spontaneous anti-C9 anti-idiotypic T cell activity falls as disease progresses, but immunization can activate the anti-idiotypic T cells to regulate the autoimmune process, (iii) that the anti-idiotypic T cells secrete IFN-gamma, but appear to control the disease by down-regulating the IFN-gamma produced by the pathogenic population of anti-p277 T cells, (iv) that intrathymic administration of the C9 idiotope peptide at 1 week of age can accelerate the disease, and (v) that administering the p277 target peptide can up-regulate the anti-idiotypic T cells and arrest the disease process. Thus, the development of NOD diabetes can be regulated by a balance between anti-idiotypic and anti-target peptide autoimmunity, and anti-idiotypic regulation can lead to changes in the cytokine secretion of the autoimmune T cells involved in the disease process. (+info)

Cutting edge: proteasome involvement in the degradation of unassembled Ig light chains. (4/883)

Several studies on disposal of nonsecreted Ig L chains have identified the endoplasmic reticulum as the site of degradation. Here, we examine degradation of a nonsecreted Ig L chain, T15L, and an experimentally endoplasmic reticulum-retained secretion-competent L chain, D16L, in the absence of H chains. We demonstrate that 1) degradation is specifically impaired by the proteasome-specific inhibitors carboxybenzyl-leucyl-leucyl-leucine vinyl sulfone (Z-L3VS) and lactacystin, 2) L chain degradation occurs early in the biosynthetic pathway, and 3) degradation does not require vesicular transport. Our findings indicate that previous assertions of L chain disposal within the endoplasmic reticulum must be modified. To our knowledge, we provide the first direct evidence supporting a new paradigm for removal of nonsecreted Ig L chains via dislocation to cytosolic proteasomes. (+info)

Neonatal exposure to idiotype induces Schistosoma mansoni egg antigen-specific cellular and humoral immune responses. (5/883)

Exposure of neonatal mice to appropriate, cross-reactive Id (CRI) preparations alters immune responsiveness, ameliorates pathology, and prolongs survival of animals upon subsequent Schistosoma mansoni infection. However, because schistosome infections profoundly affect host immunobiology, which responses are effected by neonatal Id exposure alone and which responses are influenced by infection is unclear. To directly examine the schistosome soluble egg Ag (SEA)-specific immune responses altered by CRI exposure, neonatal mice were injected with CRI-expressing (CRI+) SEA-specific Ab preparations, SEA-specific Abs that did not express CRI (CRI-), or normal mouse Ig. At 9 wk of age, only mice that were neonatally exposed to CRI+ anti-SEA Abs displayed significant SEA-specific IgG serum levels and spleen cell proliferative responses. SEA-stimulated spleen cells from these CRI+-exposed mice also produced IFN-gamma, although not at significantly higher levels than mice receiving CRI- Id or normal mouse Ig. If CRI+-exposed mice were also injected with SEA at 8 wk of age, the 9-wk IFN-gamma responses were significantly higher than those of the other neonatal injection groups. The presence of both CRI and anti-CRI in the sera of animals neonatally injected with CRI, but receiving no exposure to S. mansoni Ags or infection, suggested a functional idiotypic network led to these responses. These data demonstrate that appropriate idiotypic exposure induces B and T cell responsiveness to the Ag recognized by the Id and support the hypothesis that neonatal idiotypic exposure can be an important immunoregulatory factor in schistosomiasis. (+info)

Idiotype vaccination in human myeloma: generation of tumor-specific immune responses after high-dose chemotherapy. (6/883)

Igs contain unique portions, collectively termed idiotypes (Id), that can be recognized by the immune system. Id expressed by tumor cells in B-cell malignancies can be regarded as tumor-specific antigens and a target for vaccine immunotherapy. We have started a vaccination trial in multiple myeloma (MM) using Id-specific proteins conjugated to keyhole limpet hemocyanin (KLH) as immunogens and low doses of subcutaneous granulocyte-macrophage colony-stimulating factor (GM-CSF) or interleukin-2 (IL-2) as immunoadjuvants. Twelve patients who had previously been treated with high-dose chemotherapy followed by peripheral blood progenitor cell (PBPC) transplantation entered this study from August 1995 to January 1998. All patients were in first remission at the time of vaccination. They received subcutaneous injections of Id vaccines and immunoadjuvants in an outpatient setting. The generation of Id-specific T-cell proliferative responses was documented in 2 patients, whereas a positive Id-specific delayed-type hypersensitivity (DTH) reaction was observed in 8 of the 10 patients studied. DTH specificity was confirmed in 1 patient by investigating the reactivity to synthetic peptides derived from the VDJ sequence of the tumor-specific Ig heavy chain. None of the patients generated soluble immune responses to Id, whereas the generation of soluble and cellular immune responses to KLH was observed in 100% and 80%, respectively. Eleven patients completed the treatment, whereas 1 patient failed to finish owing to progression of disease. Freedom from disease progression (FFDP), measured from the date of first Id/KLH injection to the date of first treatment after vaccination or last follow-up, ranged from 9 to 36 months. These data indicate that the immune competence status of MM patients is still susceptible to specific immunization after high-dose chemotherapy and PBPC transplantation. It remains to be determined whether generation of Id-specific immune responses can reduce the relapse rate of patients with minimal residual disease. (+info)

scFv multimers of the anti-neuraminidase antibody NC10: length of the linker between VH and VL domains dictates precisely the transition between diabodies and triabodies. (7/883)

Single-chain Fv antibody fragments (scFvs) incorporate a polypeptide linker to tether the VH and VL domains together. An scFv molecule with a linker 5-12 residues long cannot fold into a functional Fv domain and instead associates with a second scFv molecule to form a bivalent dimer (diabody). Direct ligation of VH and VL domains further restricts association and forces three scFv molecules to associate into a trivalent trimer (triabody). We have defined the effect of linker length on scFv association by constructing a series of scFvs from anti-neuraminidase antibody NC10 in which the linker varied from one to four glycine residues. NC10 scFv molecules containing linkers of three and four residues showed a strong preference for dimer formation (diabodies), whereas a linker length of one or two glycine residues prevented the formation of diabodies and directed scFv association into trimers (triabodies). The data suggest a relatively strict transition from dimer (diabody) to trimer (triabody) upon reduction of the linker length from three to two glycine residues. Modelling studies are consistent with three residues as the minimum linker length compatible with diabody formation. Electron microscope images of complexes formed between the NC10 scFv multimers and an anti-idiotype Fab' showed that the dimer was bivalent for antigen binding and the trimer was trivalent. (+info)

Molecular and idiotypic analyses of the antibody response to Cryptococcus neoformans glucuronoxylomannan-protein conjugate vaccine in autoimmune and nonautoimmune mice. (8/883)

The antibody response to Cryptococcus neoformans capsular glucuronoxylomannan (GXM) in BALB/c mice frequently expresses the 2H1 idiotype (Id) and is restricted in variable gene usage. This study examined the immunogenicity of GXM-protein conjugates, V (variable)-region usage, and 2H1 Id expression in seven mouse strains: BALB/c, C57BL/6, A/J, C3H, NZB, NZW, and (NZB x NZW)F(1) (NZB/W). All mouse strains responded to vaccination with GXM conjugated to tetanus toxoid (TT), the relative magnitude of the antibody response being BALB/c approximately C3H > C57BL/6 approximately NZB approximately NZW approximately NZB/W > A/J. Analysis of serum antibody responses to GXM with polyclonal and monoclonal antibodies to the 2H1 Id revealed significant inter- and intrastrain differences in idiotype expression. Thirteen monoclonal antibodies (MAbs) (two immunoglobulin M [IgM], three IgG3, one IgG1, three IgG2a, two IgG2b, and two IgA) to GXM were generated from one NZB/W mouse and one C3H/He mouse. The MAbs from the NZB/W mouse were all 2H1 Id positive (Id(+)) and structurally similar to those previously generated in BALB/c mice, including the usage of a V(H) from the 7183 family and Vkappa5.1. Administration of both 2H1 Id(+) and Id(-) MAbs from NZB/W and C3H/H3 mice prolonged survival in a mouse model of cryptococcosis. Our results demonstrate (i) that V-region restriction as indicated by the 2H1 Id is a feature of both primary and secondary responses of several mouse strains; and (ii) that there is conservation of V-region usage and length of the third complementarity-determining region in antibodies from three mouse strains. The results suggest that V-region restriction is a result of antibody structural requirements necessary for binding an immunodominant antigen in GXM. (+info)

ROR-1 and the immunoglobulin light-chain idiotype expressed by the individual cancer. CARs targeting either CD33 or CD123 have ... Toxicity against CD19 results in B cell loss in circulation and in bone marrow that can be overcome by periodic immunoglobulin ... Loss of B cells can be countered with immunoglobulin. Startups including Juno Therapeutics exploit the combination of ...

https://en.wikipedia.org/wiki/Adoptive_cell_transfer

... immunoglobulin idiotypes MeSH D12.776.124.790.651.705.500 - immunoglobulin heavy chains MeSH D12.776.124.790.651.705.500.350 - ... immunoglobulin constant regions MeSH D12.776.124.486.485.680.745 - immunoglobulin idiotypes MeSH D12.776.124.486.485.705 - ... immunoglobulin a MeSH D12.776.124.486.485.114.619.026.030 - immunoglobulin a, secretory MeSH D12.776.124.486.485.114.619.026. ... immunoglobulin d MeSH D12.776.124.486.485.114.619.251.500 - immunoglobulin delta-chains MeSH D12.776.124.486.485.114.619.312 - ...

https://en.wikipedia.org/wiki/List_of_MeSH_codes_(D12.776.124)

... immunoglobulin idiotypes MeSH D23.050.705.115 - antigens, human platelet MeSH D23.050.705.230 - blood group antigens MeSH ...

https://en.wikipedia.org/wiki/List_of_MeSH_codes_(D23)

So, when a full, high-fidelity copy of the idiotype is linked to a foreign protein (KLH), and administered with an immune- ... manufactured with an IgG isotype with each treatment vaccine produced to correspond with the patient's tumor immunoglobulin ... "Idiotype vaccine therapy (BiovaxID) in follicular lymphoma in first complete remission: Phase III clinical trial results". ... This approach is used because there is a unique protein called an "idiotype" expressed exclusively on the cancerous B-cells. ...

https://en.wikipedia.org/wiki/Biovest

This cell then secretes the unique idiotype, or immunoglobulin antigen characteristic of the individual tumor, which is ...

https://en.wikipedia.org/wiki/Rescue_fusion_hybridization

Immunoglobulins or TCRs with a shared idiotope are the same idiotype. Antibody idiotype is determined by: Gene rearrangement ... In immunology, an idiotype is a shared characteristic between a group of immunoglobulin or T-cell receptor (TCR) molecules ... Allotype (immunology) Isotype (immunology) Immune network theory Immunoglobulin+idiotypes at the US National Library of ... idiotype describes the distinctive sequence and region that makes any immunoglobulin/TCR unique from others of the same type ...

https://en.wikipedia.org/wiki/Idiotype

Idiotype cross-reaction - Idiotypes are antigenic epitopes found in the antigen-binding portion (Fab) of the immunoglobulin ... Idiotype network theory, proposed by Jerne, wherein a network of antibodies capable of neutralizing self-reactive antibodies ... In this case, the host-cell receptor is envisioned as an internal image of the virus, and the anti-idiotype antibodies can ... Plotz and Oldstone presented evidence that autoimmunity can arise as a result of a cross-reaction between the idiotype on an ...

https://en.wikipedia.org/wiki/Autoimmunity

... immunoglobulin km allotypes MeSH G04.610.626.510 - immunoglobulin idiotypes MeSH G04.610.626.580 - major histocompatibility ... immunoglobulin MeSH G04.610.626.454 - immunoglobulin allotypes MeSH G04.610.626.454.586 - immunoglobulin gm allotypes MeSH ... immunoglobulin class switching MeSH G04.610.626.320.601 - gene rearrangement, b-lymphocyte, light chain MeSH G04.610.626.325 - ... immunoglobulin MeSH G04.742.675.700 - plant tumors MeSH G04.742.800.400 - gravitropism MeSH G04.742.800.700 - phototropism The ...

https://en.wikipedia.org/wiki/List_of_MeSH_codes_(G04)

The structure of immunoglobulin polypeptide chain is dictated and controlled by number of genes encoded in the germ line. ... Allotype (disambiguation) Idiotype Isotype "Pathology, Microbiology and Immunology". University of South Carolina School of ... Immunoglobulin+allotypes at the US National Library of Medicine Medical Subject Headings (MeSH) (Genetics, Transplantation ... However, it is important to mention that not all variations in immunoglobulin amino acid sequence pose as a determinant ...

https://en.wikipedia.org/wiki/Allotype_(immunology)

Immunoglobulin lambda joining 3 is a protein that in humans is encoded by the IGLJ3 gene. "Human PubMed Reference:". National ... "The anti-DNA-associated idiotype 8.12 is encoded by the V lambda II gene family and maps to the vicinity of L chain CDR1". ... Combriato G, Klobeck HG (June 1991). "V lambda and J lambda-C lambda gene segments of the human immunoglobulin lambda light ... "Entrez Gene: Immunoglobulin lambda joining 3". Paul E, Iliev AA, Livneh A, Diamond B (December 1992). " ...

https://en.wikipedia.org/wiki/IGLJ3

Idiotype Janeway, CA; Travers, P; Walport, M; et al. (2001). "Immunobiology: The Immune System in Health and Disease. 5th ... Immunoglobulin+Isotypes at the US National Library of Medicine Medical Subject Headings (MeSH) Overview at University of South ... In immunology, antibodies (immunoglobulins (Ig)) are classified into several types called isotypes or classes. The variable (V ... Stavnezer, Janet (1996). "Immunoglobulin Class Switching". Current Opinion in Immunology. 8 (2): 199-205. doi:10.1016/s0952- ...

https://en.wikipedia.org/wiki/Isotype_(immunology)

IgA1 IgA2 Immunoglobulin D (IgD) Immunoglobulin E (IgE) Immunoglobulin G (IgG) IgG1 IgG2 IgG3 IgG4 Immunoglobulin M (IgM) ... antibodies Polyclonal antibodies Autoantibody Microantibody Neutralizing antibody Classification Allotype Isotype Idiotype ... Immunoglobulin heavy chain / Immunoglobulin light chain Co-receptors Stimulatory CD21 CD19 CD81 Inhibitory CD22 Accessory ... IL10RB Immunoglobulin superfamily (Some members) CSF1 CD117 (c-KIT) IL1 receptor family (IL1R) IL1R type 1 (CD121a) IL1R type 2 ...

https://en.wikipedia.org/wiki/Outline_of_immunology

D Immunoglobulin E Immunoglobulin G Immunoglobulin heavy chain Immunoglobulin light chain Immunoglobulin M Immunoglobulin Y ... Human leukocyte antigen Humoral immunity Hybridoma technology Hyperimmune globulin Hypersensitive response Idiotopes Idiotype ... Immunofixation Immunogen Immunogenetics Immunogenicity Immunoglobulin A Immunoglobulin class switching Immunoglobulin ...

https://en.wikipedia.org/wiki/Index_of_immunology_articles

... immunoglobulin constant regions MeSH D12.776.377.715.548.680.745 - immunoglobulin idiotypes MeSH D12.776.377.715.548.705 - ... immunoglobulin a MeSH D12.776.377.715.548.114.619.026.030 - immunoglobulin a, secretory MeSH D12.776.377.715.548.114.619.026. ... immunoglobulin d MeSH D12.776.377.715.548.114.619.251.500 - immunoglobulin delta-chains MeSH D12.776.377.715.548.114.619.312 - ... immunoglobulin g MeSH D12.776.377.715.548.114.619.393.522 - immunoglobulin gamma-chains MeSH D12.776.377.715.548.114.619.393. ...

https://en.wikipedia.org/wiki/List_of_MeSH_codes_(D12.776)

Immunoglobulin-binding protein - Proteins such as protein A, protein G, and protein L that are capable of binding to antibodies ... Different antibody idiotypes, each have distinctly formed complementarity-determining regions. Allergen - A substance capable ... While antigens are the "target" of antibodies, immunoglobulin-binding proteins "attack" antibodies. T-dependent antigen - ...

https://en.wikipedia.org/wiki/Antigen

Wilson, P. C.; Wilson, K.; Liu, Y. J.; Banchereau, J.; Pascual, V.; Capra, J. D. (2000). "Receptor revision of immunoglobulin ... Evidence that the VH4-21 gene segment is responsible for the major cross-reactive idiotype". Journal of Immunology. 146 (12): ... Hasemann, C. A.; Capra, J. D. (1990). "High-level production of a functional immunoglobulin heterodimer in a baculovirus ... Pascual, V.; Capra, J. D. (1991). Human immunoglobulin heavy-chain variable region genes: Organization, polymorphism, and ...

https://en.wikipedia.org/wiki/J._Donald_Capra

Each immunoglobulin domain has a similar structure, characteristic of all the members of the immunoglobulin superfamily: it is ... In the framework of the immune network theory, CDRs are also called idiotypes. According to immune network theory, the adaptive ... Somatic recombination of immunoglobulins, also known as V(D)J recombination, involves the generation of a unique immunoglobulin ... The membrane-bound form of an antibody may be called a surface immunoglobulin (sIg) or a membrane immunoglobulin (mIg). It is ...

https://en.wikipedia.org/wiki/Antibody

Intravenous immunoglobulin (IVIG) was used successfully in an infant with IgA-associated autoimmune hemolytic anemia. ... with a distinct idiotype identified by the 9G4 rat murine monoclonal antibody. AIHA can be classified as warm autoimmune ...

https://en.wikipedia.org/wiki/Cold_autoimmune_hemolytic_anemia

In the early 1990s, Bogen and co-workers discovered a new type of collaboration between T and B-cells (Idiotype-driven T-B ... Mar;22(3):371-83.PMID 15780993 Weiss S, Bogen B. (1989) B-lymphoma cells process and present their endogenous immunoglobulin to ... Epub 2007 May 7. PMID 17485509 Lauritzsen GF, Weiss S, Dembic Z, Bogen B. (1994) Naive idiotype-specific CD4+ T cells and ... PMID 10706628 Fredriksen AB, Bogen B. (2007) Chemokine-idiotype fusion DNA vaccines are potentiated by bivalency and xenogeneic ...

https://en.wikipedia.org/wiki/Bjarne_Bogen

Yewdell J (4 October 2003). "He put the Id in Idiotype". EMBO Reports (Book review). 4 (10): 931. doi:10.1038/sj.embor.embor951 ... Many of the classical molecules of the adaptive immune system (for example, immunoglobulins and T-cell receptors) exist only in ... Saji F, Samejima Y, Kamiura S, Koyama M (May 1999). "Dynamics of immunoglobulins at the feto-maternal interface" (PDF). Reviews ... Housden NG, Harrison S, Roberts SE, Beckingham JA, Graille M, Stura E, Gore MG (June 2003). "Immunoglobulin-binding domains: ...

https://en.wikipedia.org/wiki/Immune_system

Robertson, Miranda (1981). "Genes of lymphocytes II: T-cell receptors, idiotypes and the MHC". Nature. 291 (5812): 187-188. doi ... Robertson, Miranda (1983). "Tumours of lymphocytes: What happens when cellular oncogenes collide with immunoglobulin genes". ...

https://en.wikipedia.org/wiki/Miranda_Robertson

... anti-idiotypes' (antigen receptors that react with the idiotype as if it were a foreign antigen). This theory, which builds on ... Antibodies (also known as immunoglobulin, Ig), are large Y-shaped proteins used by the immune system to identify and neutralize ... In antibody responses, B cells are activated to secrete antibodies, which are proteins also known as immunoglobulins. ... Dong Y, Taylor HE, Dimopoulos G (July 2006). "AgDscam, a hypervariable immunoglobulin domain-containing receptor of the ...

https://en.wikipedia.org/wiki/Adaptive_immune_system

... anti-idiotype vaccine - anti-inflammatory - antiandrogen - antiandrogen therapy - anti-angiogenesis - antiangiogenic - antibody ... immunoglobulin - immunological adjuvant - immunology - immunomodulation - immunophenotyping - immunoscintigraphy - ...

https://en.wikipedia.org/wiki/Index_of_oncology_articles

Somatic recombination of immunoglobulins, also known as V(D)J recombination, involves the generation of a unique immunoglobulin ... In the framework of the immune network theory, CDRs are also called idiotypes. According to immune network theory, the adaptive ... The membrane-bound form of an antibody may be called a surface immunoglobulin (sIg) or a membrane immunoglobulin (mIg). It is ... Further information: Immunoglobulin light chain. In mammals there are two types of immunoglobulin light chain, which are called ...

https://en.m.wikipedia.org/wiki/Antibody

FDA licensed immunoglobulins[edit]. The following immunoglobulins are the immunoglobulins currently approved for use for ... Immunoglobulin G (IgG) is the only antibody isotype that can pass through the human placenta, and is the most common antibody ... Immunoglobulin therapy continued to be a first line therapy in the treatment of severe respiratory diseases until the 1930s, ... In 1953, human vaccinia immunoglobulin (VIG) was used to prevent the spread of smallpox during an outbreak in Madras, India, ...

https://en.wikipedia.org/wiki/Passive_immunity

CD4+ TH1 Cells It has been found in both mice and humans that the signature cytokines for these cells is interferon gamma and lymphotoxin alpha. The main cytokine for differentiation into TH1 cells is IL-12 which is produced by dendritic cells in response to the activation of pattern recognition receptors. T-bet is a distinctive transcription factor of TH1 cells. TH1 cells are also characterized by the expression of chemokine receptors which allow their movement to sites of inflammation. The main chemokine receptors on these cells are CXCR3A and CCR5. Epithelial cells and keratinocytes are able to recruit TH1 cells to sights of infection by releasing the chemokines CXCL9, CXCL10 and CXCL11 in response to interferon gamma. Additionally, interferon gamma secreted by these cells seems to be important in downregulating tight junctions in the epithelial barrier.[4] CD8+ TC1 Cells These cells generally produce interferon gamma. Interferon gamma and IL-12 promote differentiation toward TC1 cells. T-bet ...

https://en.wikipedia.org/wiki/Cell-mediated_immunity

... anti-idiotypes' (antigen receptors that react with the idiotype as if it were a foreign antigen). This theory, which builds on ... Antibodies (also known as immunoglobulin, Ig), are large Y-shaped proteins used by the immune system to identify and neutralize ... In antibody responses, B cells are activated to secrete antibodies, which are proteins also known as immunoglobulins. ... based on interactions between idiotypes (unique molecular features of one clonotype, i.e. the unique set of antigenic ...

https://en.m.wikipedia.org/wiki/Adaptive_immune_system

Idiotype; Ig: Immunoglobulin; NSCLC: Non-small-cell lung carcinoma; OVA: Ovalbumin; PBMC: Peripheral blood mononuclear cell; ... Immunoglobulin; mAb: Monoclonal antibody; MDR: Multidrug resistant; OVA: Ovalbumin; PDBA: Poly(d,l-2,4-diaminobutyric acid); ...

https://www.medscape.com/viewarticle/772651

408. IMMUNOGLOBULINS WITH DIFFERENT SPECIFICITIES HAVE SIMILAR IDIOTYPES. E. Enohofer, C.P.J. Glaudemans and M.J. Boma. Mol. ... 400. THE BINDING OF INULO-OLIGOSACCHARIDES TO HOMOGENOUS IMMUNOGLOBULINS B109 AND A47N. M.K. Das, D.G. Streefkerk and C.P.J. ... HOMOGENOUS, ANTI-GALACTAN IMMUNOGLOBULINS. THE QUESTION OF SPECIFICITY. B.N Manjula and C.P.J. Glaudemans. Immunochemistry, ( ... 385. BINDING STUDIES ON ANTI-FRUCTOFURANAN MOUSE MYELOMA IMMUNOGLOBULINS A47N, A4, U61, AND E109. D.G. Streefkerk and C.P.J. ...

https://www.niddk.nih.gov/research-funding/at-niddk/labs-branches/laboratory-bioorganic-chemistry/carbohydrates-section/publications/publications-since-1929

Immunoglobulin deficiency and idiotype expression in children developing Haemophilus influenzae type b disease after ... had evidence of low immunoglobulin levels (34).. COMBINATION VACCINES. TETRAMUNE{TM}. On March 30, 1993, the Food and Drug ... subnormal immunoglobulin concentrations were present in approximately 40% of those who developed invasive Hib disease (33). ...

https://wonder.cdc.gov/wonder/prevguid/p0000326/p0000326.asp

New Immunoglobulin Knock-in Mice for Idiotype (Id)-Driven T-B Collaboration. Scandinavian Journal of Immunology. ISSN 0300-9475 ... B cell presentation of immunoglobulin Idiotypes to Id-specific T cells results in spontaneous lethal autoimmunity on an ... B cells spontaneously presenting their Idiotype are stimulated by Idiotype-specific CD4+ T cells to proliferate and secrete ... B cells spontaneously presenting their Idiotype are stimulated by Idiotype-specific CD4+ T cells to proliferate and secrete ...

https://www.med.uio.no/klinmed/personer/vit/ludvig/index.html

E5.478.594.430.400 Immunoglobulin Idiotypes G2.111.570.60.425.580 Immunohistochemistry E1.450.495.435 E1.370.225.500.607.512 ...

https://decs.bvs.br/P/mnchg2012.txt

Stimulation of cytotoxic T cells against idiotype immunoglobulin of malignant lymphoma with protein-pulsed or idiotype- ...

https://clltopics.org/Reference.html

Immunoglobulin Idiotype Medicine and Dentistry 60% * Autoantibodies Immunology and Microbiology 60% View full fingerprint ... We have termed these nephritogenic idiotypic markers collectively as idiotypes-lupus nephritis-SNF1 or Id(LN)F1. The Id564 ... Here we analyzed the idiotypic profile of the broad spectrum of immunoglobulins deposited in the nephritic kidneys of SNF1 mice ... To establish that the autoantibody idiotypes detected in the renal lesions were not there as a result of nonspecific trapping, ...

https://www.scholars.northwestern.edu/en/publications/the-nzb-x-swr-model-of-lupus-nephritis-ii-autoantibodies-deposite

Anti-immunoglobulin antibodies. I. Expression of cross-reactive idiotypes and Ir gene control of the response to IgG2a of the b ... Cellular basis of regulation of expression of idiotype. II. Immunity to anti-MOPC-460 idiotype antibodies increases the level ... Cellular basis of regulation of expression of idiotype. I. T-suppressor cells specific for MOPC 460 idiotype regulate the ...

https://rupress.org/jem/search-results?f_Authors=C+Bona

Idiotype, Ig Idiotype, Immunoglobulin Idiotypes, Ig Idiotypes, Immunoglobulin Ig Idiotype Ig Idiotypes Immunoglobulin Idiotype ... Idiotype, Immunoglobulin. Idiotypes, Ig. Idiotypes, Immunoglobulin. Ig Idiotype. Ig Idiotypes. Immunoglobulin Idiotype. ... Immunoglobulin Idiotypes - Preferred Concept UI. M0011109. Scope note. Unique genetically-controlled determinants present on ... Idiotypes des immunoglobulines Entry term(s):. Idiotype, Ig. ... The idiotype appears to represent the antigenicity of the ...

https://decs.bvsalud.org/en/ths/resource/?id=7313

Immunoglobulin Idiotypes --immunology. en_US. dc.subject.mesh. Pregnancy --immunology. en_US. ...

https://imsear.searo.who.int/handle/123456789/22180?mode=full

Immunoglobulin idiotype (substance). Code System Preferred Concept Name. Immunoglobulin idiotype (substance). Concept Status. ...

https://phinvads.cdc.gov/vads/ViewCodeSystemConcept.action?oid=2.16.840.1.113883.6.96&code=42799008

... an immunoglobulin genetic marker for the light chain variable region affects inheritance of expression of an idiotype ... The effect of light chain gene expression on the inheritance of an idiotype associated with primary anti-(4-hydroxy-3- ... The effect of light chain gene expression on the inheritance of an idiotype associated with primary anti-(4-hydroxy-3- ... A mendelian idiotype is demonstrable in the heteroclitic anti-NP antibodies of the mouse ...

https://m.wikidata.org/wiki/Q39557988

"Immunoglobulin Idiotypes", "type": "DefinedTerm" }, { "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", "name": "Models, ...

https://scigraph.springernature.com/pub.10.1007/bf02458443

Thyrotropin; Graves disease; Immunoglobulins. Medical Subject Heading:. Immunoglobulin Idiotypes; Antithyroid Agents. Actions ...

https://research.library.mun.ca/9698/

This is analogous to antibody-induced immunoglobulin allotype and idiotype suppression. Only certain sources of anti-C5 are ...

https://journals.aai.org/jimmunol/article/120/2/400/9729/Antibody-Induced-Suppression-of-the-Fifth

... contains several immunoglobulin-binding domains capable of binding both the Fcγ of IgG antibodies and the Fab of VH3-idiotype ...

https://wwwnc.cdc.gov/eid/article/26/11/20-1442_article

E5.478.594.430.400 Immunoglobulin Idiotypes G2.111.570.60.425.580 Immunohistochemistry E1.450.495.435 E1.370.225.500.607.512 ...

https://decs2017.bvsalud.org/E/mnchg2012.txt

E5.478.594.430.400 Immunoglobulin Idiotypes G2.111.570.60.425.580 Immunohistochemistry E1.450.495.435 E1.370.225.500.607.512 ...

https://decs2015.bvsalud.org/E/mnchg2012.txt

E5.478.594.430.400 Immunoglobulin Idiotypes G2.111.570.60.425.580 Immunohistochemistry E1.450.495.435 E1.370.225.500.607.512 ...

https://decs2013.bvsalud.org/P/mnchg2012.txt

E5.478.594.430.400 Immunoglobulin Idiotypes G2.111.570.60.425.580 Immunohistochemistry E1.450.495.435 E1.370.225.500.607.512 ...

https://decs2014.bvsalud.org/I/mnchg2012.txt

E5.478.594.430.400 Immunoglobulin Idiotypes G2.111.570.60.425.580 Immunohistochemistry E1.450.495.435 E1.370.225.500.607.512 ...

https://decs2020.bvsalud.org/E/mnchg2012.txt

E5.478.594.430.400 Immunoglobulin Idiotypes G2.111.570.60.425.580 Immunohistochemistry E1.450.495.435 E1.370.225.500.607.512 ...

https://decs2016.bvsalud.org/E/mnchg2012.txt

E5.478.594.430.400 Immunoglobulin Idiotypes G2.111.570.60.425.580 Immunohistochemistry E1.450.495.435 E1.370.225.500.607.512 ...

https://decs2019.bvsalud.org/E/mnchg2012.txt

E5.478.594.430.400 Immunoglobulin Idiotypes G2.111.570.60.425.580 Immunohistochemistry E1.450.495.435 E1.370.225.500.607.512 ...

https://decs2018.bvsalud.org/P/mnchg2012.txt

E5.478.594.430.400 Immunoglobulin Idiotypes G2.111.570.60.425.580 Immunohistochemistry E1.450.495.435 E1.370.225.500.607.512 ...

https://decs2012.bvsalud.org/P/mnchg2012.txt

The 4B4 VH and VL were cloned into the ImmunoZap λ expression vector to produce three recombinant immunoglobulin polypeptides. ... Dang H, Lazaridis K, Talal N, Fischbach M, Sanz I. Cloning of a Human IgM Autoantibody Bearing a Cross-Reactive Idiotype in a λ ... The 4B4 idiotype was found predominantly on the VH. This report describes: (i) a method for producing recombinant ... The 4B4 idiotype was found predominantly on the VH. This report describes: (i) a method for producing recombinant ...

https://mayoclinic.pure.elsevier.com/en/publications/cloning-of-a-human-igm-autoantibody-bearing-a-cross-reactive-idio

Immunoglobulin Allotypes [G12.500.400] * Immunoglobulin Idiotypes [G12.500.450] * Major Histocompatibility Complex [G12.500.500 ... Hypermutation, Somatic, Immunoglobulin Ig Somatic Hypermutation Immunoglobulin Somatic Hypermutation Somatic Hypermutation, Ig ... Somatic Hypermutation, Immunoglobulin Preferred Term Term UI T437229. Date02/26/2001. LexicalTag NON. ThesaurusID NLM (2002). ... Immunoglobulin Somatic Hypermutation Term UI T439153. Date03/14/2001. LexicalTag NON. ThesaurusID NLM (2002). ...

https://meshb.nlm.nih.gov/record/ui?ui=D027041

Grant, M. D., Whaley, M. D., Mayne, A., Hoffmann, G. W. and Ansari A. A. Similar abnormalities of idiotype and immunoglobulin ... Hoffmann, G. W. and Grant, M. D. On AIDS, alloimmunity and autoimmunity, in Idiotype Networks in Biology and Medicine, A. D ...

https://phas.ubc.ca/~hoffmann/pub2.html

... we examined the expression of tumor idiotype, immunoglobulin (Ig) gene rearrangements and sequence of Ig variable genes in ... All 16 cases analyzed expressed surface immunoglobulin (sIg) on both the FL and the tDL, though the immunophenotype of one case ...

https://stanfordhealthcare.org/publications/756/75615.html

The idiotype appears to represent the antigenicity of the antigen-binding site of the antibody and to be genetically codetermined with it. (bvsalud.org)
This is analogous to antibody-induced immunoglobulin allotype and idiotype suppression. (aai.org)
The monoclonal antibody 4B4 is a human IgM,κ which expresses a cross-reactive lupus-associated idiotype and has anti-Sm binding activity. (elsevier.com)
The 4B4 idiotype was found predominantly on the V H . This report describes: (i) a method for producing recombinant immunoglobulin molecules from an IgM-secreting B cell line and (ii) the ability of recombinant antibody fragments expressed in Escherichia coli to retain the structural and antigenic properties of the native molecule. (elsevier.com)
This report describes: (i) a method for producing recombinant immunoglobulin molecules from an IgM-secreting B cell line and (ii) the ability of recombinant antibody fragments expressed in Escherichia coli to retain the structural and antigenic properties of the native molecule. (elsevier.com)
B cell are monoclonal, from one cancerous B cell expressing a distinctive immunoglobulin, as well as the adjustable region of the antibody (termed idiotype) continues to be utilized as a distinctive patient particular tumor antigen. (cancer-ecosystem.com)
To better understand the molecular basis of the antibody response, the heavy- and light-chain immunoglobulin variable region (VH and VL, respectively) sequences of seven monoclonal antibodies (MAbs) to GXM were determined. (pasteur.fr)
Cold agglutinins commonly have variable heavy-chain regions encoded by VH, with a distinct idiotype identified by the 9G4 rat murine monoclonal antibody. (medscape.com)
An antibody ( Ab ), also known as an immunoglobulin ( Ig ), [1] is a large, Y-shaped protein used by the immune system to identify and neutralize foreign objects such as pathogenic bacteria and viruses . (wikipedia.org)
The terms antibody and immunoglobulin are often used interchangeably, [1] though the term 'antibody' is sometimes reserved for the secreted, soluble form, i.e. excluding B-cell receptors. (wikipedia.org)
Immunoglobulin G (IgG) is the only antibody isotype that can pass through the human placenta, and is the most common antibody of the five types of antibodies found in the body. (wikipedia.org)

Cloning of a Human IgM Autoantibody Bearing a Cross-Reactive Idiotype in a λ. (elsevier.com)
Dive into the research topics of 'Cloning of a Human IgM Autoantibody Bearing a Cross-Reactive Idiotype in a λ. (elsevier.com)

Antibodies are glycoproteins belonging to the immunoglobulin superfamily . (wikipedia.org)
Inflammatory mediators include a variety of protein families, including adhesion molecules such as integrins and members of the immunoglobulin superfamily, as well as other cytokines and chemokines. (spandidos-publications.com)

Lymphoma cells might be an attractive target for anti-idiotype vNAR molecules since B-cell lymphoma cells exhibit tumor-specific and functionally active B-Cell receptors (BCR). (tu-darmstadt.de)
Ciavarra, RP, Vivetta, ES & Forman, J 1986, ' Growth inhibition of a B cell leukemia: Evidence implicating an anti-idiotype immune response for protective tumor immunity ', Journal of Immunology , vol. 137, no. 4, pp. 1371-1375. (elsevier.com)

A vaccine comprising an autologous idiotype proteins conjugated to keyhole limpet hemocyanin (KLH) continues to be found in follicular lymphoma [4]. (cancer-ecosystem.com)

The Id(LN)F 1 positive family of antibodies were also found in high levels in the sera of old SNF 1 mice, but they could not be detected in the sera of NZB or SWR mice, nor were they present in the immunoglobulins deposited in the kidneys of rate old NZB mice. (northwestern.edu)
Anti-immunoglobulin antibodies. (rupress.org)
Immunity to anti-MOPC-460 idiotype antibodies increases the level of anti-trinitrophenyl antibodies bearing 460 idiotypes. (rupress.org)
I. T-suppressor cells specific for MOPC 460 idiotype regulate the expression of cells secreting anti-TNP antibodies bearing 460 idiotype. (rupress.org)
In MAbs 302 and 386, respectively, the VH uses VHGAM-like gene elements and JH2 and JH3 and has six and four codon D segments, and VL uses VK4/5-like gene elements and JK1.VH usage, MAb 2H1 idiotype expression, and fine specificity mapping define a minimum of three GXM epitopes which elicit protective antibodies. (pasteur.fr)
This study was performed to determine antisperm antibodies in cervicovaginal secretions and serum of infertile women and also measure serum levels of immunoglobulins (IgG, IgM and IgA). (jri.ir)

The idiotypic determinants have been precisely located to the IMMUNOGLOBULIN VARIABLE REGION of both immunoglobin polypeptide chains. (bvsalud.org)
They are comprised of two heavy (IMMUNOGLOBULIN HEAVY CHAINS) and two light chains (IMMUNOGLOBULIN LIGHT CHAINS) with additional ancillary polypeptide chains depending on their isoforms. (edu.au)

Multiple myeloma (MM) is a plasma cell malignancy with clonal proliferation of neoplastic plasma cells in bone marrow with monoclonal immunoglobulin production leading to skeletal destruction. (hindawi.com)
rarely, it may involve monoclonal immunoglobulin G (IgG), immunoglobulin A (IgA), or λ light chain restriction. (medscape.com)
as human or animal blood plasma or serum , as pooled human immunoglobulin for intravenous ( IVIG ) or intramuscular (IG) use, as high-titer human IVIG or IG from immunized donors or from donors recovering from the disease, and as monoclonal antibodies (MAb). (wikipedia.org)

To investigate the clonal relationship between follicular lymphoma (FL) and transformed diffuse lymphoma (tDL), we examined the expression of tumor idiotype, immunoglobulin (Ig) gene rearrangements and sequence of Ig variable genes in paired tissue specimens. (stanfordhealthcare.org)

I. Expression of cross-reactive idiotypes and Ir gene control of the response to IgG2a of the b allotype. (rupress.org)
A programmed mutation process whereby changes are introduced to the nucleotide sequence of immunoglobulin gene DNA during development. (nih.gov)

The image below is a schematic representation of an immunoglobulin G molecule. (medscape.com)
Schematic representation of an immunoglobulin G molecule. (medscape.com)

Intravenous immunoglobulin (IVIG) contains the pooled immunoglobulin G (IgG) immunoglobulins from the plasma of approximately a thousand or more blood donors. (medscape.com)
It can be diagnosed by measuring the amount of IgG in a newborn's blood, and is treated with intravenous administration of immunoglobulins. (wikipedia.org)

Due to the importance of ASAs in reproduction, this study was done to detect them in the serum and pelvic discharges (cervicovaginal secretions) and measure immunoglobulin (IgG, IgM and IgA) levels of infertile women in comparison with the fertile control group. (jri.ir)

The high content of anti-idiotypes against autoantibodies in IVIG facilitates its ability to neutralize autoantibodies, as is shown in patients with acquired hemophilia due to autoantibodies against factor VIII . (medscape.com)

The major immunoglobulin isotype class in normal human serum. (edu.au)
Represents 15-20% of the human serum immunoglobulins, mostly as the 4-chain polymer in humans or dimer in other mammals. (edu.au)
Rabbit anti-idiotypic serum was made to the previously characterized murine MAb 2H1 and used to study MAb 2H1 idiotype expression in other GXM-binding MAbs and immune sera. (pasteur.fr)
Serum levels of immunoglobulins (IgG, IgA and IgM) were measured in the participants using single radial immune diffusion. (jri.ir)
Thus, quantitation of immunoglobulins in the serum and cervical mucus of infertile women is of significance (14, 15). (jri.ir)

The 4B4 idiotype was found predominantly on the VH. (elsevier.com)
A chronic form of glomerulonephritis characterized by deposits of predominantly IMMUNOGLOBULIN A in the mesangial area (GLOMERULAR MESANGIUM). (edu.au)

To establish that the autoantibody idiotypes detected in the renal lesions were not there as a result of nonspecific trapping, five separate batches of kidney eluates obtained from 100 SNF 1 kidneys were analyzed. (northwestern.edu)

Here we analyzed the idiotypic profile of the broad spectrum of immunoglobulins deposited in the nephritic kidneys of SNF 1 mice and found a restricted idiotypic diversity. (northwestern.edu)
We have termed these nephritogenic idiotypic markers collectively as idiotypes-lupus nephritis-SNF 1 or Id(LN)F 1 . (northwestern.edu)

Cellular basis of regulation of expression of idiotype. (rupress.org)
The 4B4 V H and V L were cloned into the ImmunoZap λ expression vector to produce three recombinant immunoglobulin polypeptides. (elsevier.com)

Parasitologic and clinical human response to immunoglobulin administration in falciparum malaria. (ajtmh.org)

IVIGs are sterile, purified IgG products manufactured from pooled human plasma and typically contain more than 95% unmodified IgG, which has intact Fc-dependent effector functions and only trace amounts of immunoglobulin A (IgA) or immunoglobulin M (IgM). (medscape.com)

He underwent palliative involved field 3D conformal photon or en face electron therapy concurrently with various chemotherapy regimens and achieved good to complete response with palliation of pain at the irradiated sites. (hindawi.com)
A composite endpoint involving the Schirmer-I test, unstimulated whole salivary flow, fatigue, erythrocyte sedimentation rate (ESR), and immunoglobulin G (IgG) was devised to provide a clinically meaningful assessment of response, defined as a ≥20% improvement in at least two of the aforementioned parameters, with ≥20% reduction in ESR and/or IgG considered as a single combined criterion. (biomedcentral.com)

All 16 cases analyzed expressed surface immunoglobulin (sIg) on both the FL and the tDL, though the immunophenotype of one case of FL could not be definitively determined. (stanfordhealthcare.org)
[ 1 ] Donath-Landsteiner hemolytic anemia is also caused by a cold-reacting immunoglobulin, but most cases are due to polyclonal IgG. (medscape.com)

Sufferers getting the idiotype vaccine acquired a better disease free success of 44.2 months in comparison to 30.six months for the control arm. (cancer-ecosystem.com)

This may reflect different proportions of IgM and IgG anti-Fab' in their sera, differences in the average avidity of these antibodies, or differences in the reciprocal relationships within the idiotypic network that result in release of antibodies by certain antibody-producing cells, but not by clones that produce complementary idiotypes. (nih.gov)
The generation of monoclonal anti-idiotype antibodies to human B cell-derived leukemias and lymphomas. (jimmunol.org)
We developed murine anti-idiotype monoclonal antibodies for each of four patients with B cell-derived leukemias and lymphomas. (jimmunol.org)
Idiotypic immunoglobulin was isolated from mouse X human tumor-cell hybridomas or from patients' serum and was used to immunize mice for the development of murine anti-idiotype monoclonal antibodies. (jimmunol.org)
Each patient's anti-idiotype antibodies demonstrated reactivity restricted to the immunizing immunoglobulin, thereby limiting their therapeutic utility to a single individual. (jimmunol.org)
Large populations of idiotype-bearing cells were detectable in biopsy specimens from patients K.T. and L.H. In contrast, although bone marrow specimens from patient G.D. were apparently devoid of morphologically abnormal cells, a small, highly fluorescent population of cells was demonstrable underscoring the potential utility of these antibodies for posttreatment evaluation as well as for therapy. (jimmunol.org)
In a fourth patient, H.M., anti-idiotype antibodies developed against the circulating macroglobulin isolated from his plasma failed to react with either his circulating or bone marrow hairy cell leukemia cells. (jimmunol.org)
Thus, the presence of two distinct malignant B cell clones were discovered in this individual through the use of anti-idiotype monoclonal antibodies. (jimmunol.org)
Anti-idiotype antibodies, therefore, represent a highly specific tool for the evaluation and potential therapy of B cell malignancies in individual patients. (jimmunol.org)
Idiotypes are determined by the structure of the variable regioons of antibodies. (kuzemkinomo.ru)
Idiotypes are antibodies that recognize different specific epitopes. (kuzemkinomo.ru)
Immunoglobulin molecules are antibodies that react with specific antigens, although in many circumstances, the specificity of a given immunoglobulin antibody is unknown. (nih.gov)
Serum proteins that are categorized loosely by their electrophoretic mobility as alpha globulins that inhibit proteases, beta globulins that exist as various enzymes, and gamma globulins that mainly comprise immunoglobulins (antibodies). (jacksonimmuno.com)
Current studies of immunoglobulin variable region genes encoding antiDNA antibodies reveal no disease associated polymorphisms. (elsevier.com)
Maternal serum was tested for CMV immunoglobulin G antibodies at a median of 10 (interquartile range: 8-12) weeks gestation (n = 1501). (bvsalud.org)
V. To determine whether anti-idiotype antibodies directed against blinatumomab develop with blinatumomab treatment in this study. (ucsd.edu)
Results showed that purified human anti-Id antibodies (human Ab2) recognized specifically the idiotype of some murine monoclonal anti-gp43 (17c and 3e) but not others (40.d7, 27a, and 8a). (ecmnp2015.com)
The presence of immunoglobulin Y (IgY) in egg yolks was first reported by Klemperer in 1983 and since 1992 the extraction of polyclonal IgY from chicken eggs has become an attractive alternative method to bleeding animals for immunoglobulin (IgG) antibodies. (affinityimmuno.com)
Antibodies or immunoglobulins (Ig's) are specialized Y-shaped proteins that bind like a lock-and-key to foreign invaders entering the body through sites of injury or mucosal membranes. (unitsci.com)
mission, but the study team confirmed detectable serum nucleocapsid immunoglobulin G (IgG) antibodies against SARS-CoV-2 (the patient had not been previously vaccinated against COVID-19 and anti-spike antibodies were not tested). (thailandmedical.news)

The National Institutes of Health Consensus Development Conference on Intravenous Immunoglobulin: Prevention and Treatment of Disease brought together biomedical scientists in immunology, infectious disease, and pediatrics, as well as health care providers, patients and their families, and the public to address the safe and effective uses of intravenous immunoglobulin (IVIG) preparations. (nih.gov)

Intravenous immunoglobulin (IVIG) contains the pooled immunoglobulin G (IgG) immunoglobulins from the plasma of approximately a thousand or more blood donors. (medscape.com)
The high content of anti-idiotypes against autoantibodies in IVIG facilitates its ability to neutralize autoantibodies, as is shown in patients with acquired hemophilia due to autoantibodies against factor VIII . (medscape.com)
Although initially used for immune deficiency states, intravenous immunoglobulin (IVIG) has also been utilized as a prophylactic and therapeutic reagent in a variety of other conditions. (nih.gov)
To assess the usefulness of IVIG in diseases where substantive data existed, the National Institute of Allergy and Infectious Diseases and the Office of Medical Applications of Research of the National Institutes of Health convened a Consensus Development Conference on Intravenous Immunoglobulin: Prevention and Treatment of Disease on May 21-23, 1990. (nih.gov)
Intravenous immunoglobulin (IVIg) is a sterile, highly purified, unmodified immunoglobulin G (IgG) preparation (95%) with only traces of IgG and IgM. (premiumconsulting.com.pl)
N2 - Objective: To test the adverse effects and viral safety of intravenous immunoglobulin (IVIg) use in autoimmune diseases. (premiumconsulting.com.pl)
Intravenous immunoglobulin (IVIG) is a mainstay of therapy in many disorders. (premiumconsulting.com.pl)
intravenous immunoglobulin (IVIg) or subcutaneous immunoglobulin (SCIg). (premiumconsulting.com.pl)
There are several intravenous immunoglobulin (IVIg) immunoglobulin products available. (premiumconsulting.com.pl)
immunoglobulin for intravenous administration (IVIg). (premiumconsulting.com.pl)
This guideline should be read in conjunction with the Guideline on the clinical investigation of human normal immunoglobulin for intravenous administration (IVIg) (EMA/CHMP/BPWP/94033/2007 rev. 2). (premiumconsulting.com.pl)
TBSF" Human IVIG TW PI 11.00 Page 1 of 27 "TBSF" Human Immunoglobulin for Intravenous Use Taiwan Imported Biological Product Permit No. 000841 Department of Health NAME OF THE MEDICINE Human Normal Immunoglobulin solution for intravenous infusion. (premiumconsulting.com.pl)
Intravenous immunoglobulin (IVIG) is widely being used for the treatment of deficiency disorders such as hypogammaglobulinemia, Kawasaki disease, multifocal motor neuropathy, and chronic inflammatory demyelinating polyneuropathy. (premiumconsulting.com.pl)
Intravenous immunoglobulin (IVIG) is a therapeutic biologic agent that has been prescribed for over two decades to treat various neuromuscular conditions. (premiumconsulting.com.pl)
15.11.2021· The Intravenous Immunoglobulin (IVIg), Oncology and Anasthesia fundamental market overview, market share, import-export status, and pricing structure is presented. (premiumconsulting.com.pl)

The GM 4672 lymphoblastoid cell line has been used in cell hybridization experiments with peripheral blood lymphocytes (PBLs) in order to generate human-human hybridomas that secrete immunoglobulins directed against a number of different autoantigens. (iospress.com)

We then statistically analyzed differences in presentation pattern, in terms of tumor histology, immunoglobulin isotype, AGS location and amino acid composition. (cun.es)
Isotype, Allotype & Idiotype - What is the Difference? (kuzemkinomo.ru)

Schnitzler syndrome is an autoinflammatory disease characterized by chronic, nonpruritic urticaria in association with recurrent fever, bone pain, arthralgia or arthritis, and a monoclonal gammopathy, most often of the immunoglobulin M (IgM) subtype. (medscape.com)

We sequenced the tumor-specific immunoglobulin heavy chain variable region fragment, including complementarity-determining regions 2 and 3, of forty-seven consecutive patients with a B-cell malignancy enrolled in idiotype vaccine clinical trials. (cun.es)

In immunology, an idiotype is a shared characteristic between a group of immunoglobulin or T See also[edit]. (kuzemkinomo.ru)

Immunoglobulins are proteins produced by cells of the B lymphocyte lineage that are the major effector molecules of the humoral immune system. (nih.gov)

During aging, adaptive immunity is severely compromised, due in part to decreased production of B lymphocytes and loss of immunoglobulin (Ig) diversity. (silverchair.com)

Artificial peptidesSynthetic peptides matching to adjustable parts of 2C3-Ig, various other anti-DNA immunoglobulins, and an unrelated control peptide, CEMSDMSFSKDWSFYI, utilized as complete in Desk 1, were bought Carfilzomib from Alpha Diagnostic International, Inc. (San Antonio, TX). (biomaterials-2011-dfg-nsf-conference.com)
METHODS: In vitro natalizumab arm exchange was conducted, along with peptide mimotope and anti-idiotype surface capture chemistry, to enable the development of enzyme-linked immunosorbent assays (ELISAs). (bvsalud.org)
The encoded protein contains an N-terminal signal peptide, two pairs of immunoglobulin-like domains, separated by a heptad peptide sequence, and a C-terminal transmembrane domain. (genscript.com)

The anti-gp43 MAbs 17c, 40.d7, 27a, 3e, and 8a (all immunoglobulin G2b [IgG2b], light chain) (16, 29) and the anti-anti-carcinoembryonic antigen MAb 6.C4 (IgG2b) (26) were used in EIAs. (ecmnp2015.com)
An immunoglobulin molecule that reacts specifically with another (usually foreign) molecule, the antigen. (genscript.com)

The best developed version of immune network theory is called the symmetrical network theory, in which the distinction between idiotype and paratope plays no role. (kuzemkinomo.ru)
Immunoglobulin preparations from human blood were first used in clinical medicine in 1952 to treat immune deficiency conditions. (nih.gov)

High levels of anti-immunoglobulins that react with Fab' fragments of IgG have been observed in sera of patients with rheumatoid arthritis (RA). (nih.gov)

9. Immunoglobulin M (IgM) multiple myeloma versus Waldenström macroglobulinemia: diagnostic challenges and therapeutic options: two case reports. (nih.gov)

The unique immunoglobulin idiotype (Id) expressed by each B-cell lymphoma is a target for immunotherapy. (nih.gov)

IVIGs are sterile, purified IgG products manufactured from pooled human plasma and typically contain more than 95% unmodified IgG, which has intact Fc-dependent effector functions and only trace amounts of immunoglobulin A (IgA) or immunoglobulin M (IgM). (medscape.com)

11. Immunoglobulin M concentration in Waldenström macroglobulinemia: correlation with bone marrow B cells and plasma cells. (nih.gov)
However, examination of an enlarged inguinal lymph node revealed the presence of a large number of idiotype-bearing cells. (jimmunol.org)
This mAb, secreted by an anti-phthalate hybridoma clone, provides intensive homology with BV04-01, an anti-DNA immunoglobulin determined in autoimmune-susceptible, lupus-prone NZB/W F1 mice.16 Despite such self-reactivity and homology, BALB/c mice, however, not NZB/W F1 mice, are protected through the undesireable effects of such anti-DNA B cells. (biomaterials-2011-dfg-nsf-conference.com)
We record right here that peptides matching to the large- and light-chain adjustable locations (idiotype) of 2C3-Ig stimulate splenic T cells from BALB/c mice, however, not from prone NZB/W F1 mice, and generate idiotype-specific Compact disc8+ T cells that are cytotoxic for DNA-binding 2C3 hybridoma clones highly. (biomaterials-2011-dfg-nsf-conference.com)

In our series, all cases of FL had AGS within their tumor-specific immunoglobulin heavy chain variable regions. (cun.es)
METHODS: We used self-reported data from Zika en Embarazadas y Niños (ZEN), a cohort study of women in early pregnancy across three regions of Colombia during 2017-2018. (bvsalud.org)

In the past decade, several immunoglobulin preparations for intravenous administration have become available. (nih.gov)

GM 4672 immunoglobulin variable region heavy and light chain family usage was originally assigned to VH1 and VK1, respectively. (iospress.com)

Zika en Embarazadas y Niños (ZEN) is a prospective cohort study designed to identify risk factors and modifiers for Zika virus (ZIKV) infection in pregnant women, partners, and infants, as well as to assess the risk for adverse maternal, fetal, infant, and childhood outcomes of ZIKV and other congenital infections. (bvsalud.org)

Among B-cell malignancies, follicular lymphomas (FL) more frequently show acquired, potential N-glycosylation sites (AGS) within tumor-specific immunoglobulin. (cun.es)

Anti-idiotype generation, custom immuno-assay development & validation. (synabs.be)

En cliquant sur « Accepter tous les cookies », vous acceptez le stockage de cookies sur votre appareil pour améliorer la navigation sur le site, analyser son utilisation et contribuer à nos efforts de marketing pour soutenir la recherche. (pasteur.fr)
Les cookies nécessaires aident à rendre un site Web utilisable en permettant des fonctions de base comme la navigation de page et l'accès aux zones sécurisées du site Web. (pasteur.fr)

This statement was originally published as: Intravenous Immunoglobulin: Prevention and Treatment of Disease. (nih.gov)
For making bibliographic reference to the statement in the electronic form displayed here, it is recommended that the following format be used: Intravenous Immunoglobulin: Prevention and Treatment of Disease. (nih.gov)

Through the entire text, unless mentioned in any other case, the 9-mer peptides matching to CDR1, CDR3 and CDR2 parts of immunoglobulin large and light stores are specified as VH1-9, VH2-9, VH3-9, and Carfilzomib VL1-9, VL2-9, and VL3-9, respectively. (biomaterials-2011-dfg-nsf-conference.com)

Publications Since 1929 | Carbohydrates Section | NIDDK (niddk.nih.gov)

Robert Tibshirani's Profile | Stanford Profiles (profiles.stanford.edu)

Ash A. Alizadeh, MD/PhD's Profile | Stanford Profiles (profiles.stanford.edu)

Anatomy7

Organisms4

Diseases5

Chemicals and Drugs51

Analytical, Diagnostic and Therapeutic Techniques and Equipment5

Phenomena and Processes19

Information Science3

Health Care1

Idiotype vaccination using dendritic cells after autologous peripheral blood stem cell transplantation for multiple myeloma--a feasibility study. (1/883)

DNA vaccination against the idiotype of a murine B cell lymphoma: mechanism of tumor protection. (2/883)

Regulation of NOD mouse autoimmune diabetes by T cells that recognize a TCR CDR3 peptide. (3/883)

Cutting edge: proteasome involvement in the degradation of unassembled Ig light chains. (4/883)

Neonatal exposure to idiotype induces Schistosoma mansoni egg antigen-specific cellular and humoral immune responses. (5/883)

Idiotype vaccination in human myeloma: generation of tumor-specific immune responses after high-dose chemotherapy. (6/883)

scFv multimers of the anti-neuraminidase antibody NC10: length of the linker between VH and VL domains dictates precisely the transition between diabodies and triabodies. (7/883)

Molecular and idiotypic analyses of the antibody response to Cryptococcus neoformans glucuronoxylomannan-protein conjugate vaccine in autoimmune and nonautoimmune mice. (8/883)

Immunoglobulin Idiotypes

Immunoglobulins

Immunoglobulin G

Immunoglobulin M

Immunoglobulin A

Antibodies, Anti-Idiotypic

Myeloma Proteins

Immunoglobulin Heavy Chains

Cross Reactions

Immunoglobulin Light Chains

Immunoglobulin Variable Region

Genes, Immunoglobulin

Antibody Specificity

Immunoglobulin kappa-Chains

Immunoglobulins, Intravenous

Binding Sites, Antibody

Lupus Vulgaris

Immunoglobulin Allotypes

Epitopes

Immunoglobulin E

B-Lymphocytes

Immunoglobulin A, Secretory

Antibodies, Monoclonal

Antibodies, Antinuclear

Immunoglobulin mu-Chains

Immunoglobulin Fab Fragments

Autoantibodies

Rheumatoid Factor

Plasmacytoma

Immunoglobulin Isotypes

Immunoglobulin lambda-Chains

Mice, Inbred BALB C

Antibody Formation

Immunoglobulin D

Immunoglobulin Constant Regions

Immunoglobulin Fc Fragments

Hybridomas

Antigen-Antibody Reactions

Haptens

Phosphorylcholine

Enzyme-Linked Immunosorbent Assay

Immune Sera

Trinitrobenzenes

Immunoglobulin Class Switching

Antigen-Antibody Complex

Immunoglobulin gamma-Chains

Immunoglobulin J-Chains

Rabbits

Immunoglobulin Fragments

Lupus Erythematosus, Systemic

Antibodies

Immunization

Receptors, Polymeric Immunoglobulin

Mice, Inbred Strains

Antibody-Producing Cells

Immunoglobulin Joining Region

Antibodies, Bacterial

Spleen

Hemagglutination Inhibition Tests

Glomerulonephritis, IGA

Mice, Inbred A

T-Lymphocytes

Receptors, Antigen, B-Cell

Amino Acid Sequence

Dose-Response Relationship, Immunologic

Genes, Immunoglobulin Heavy Chain

Somatic Hypermutation, Immunoglobulin

DNA

Immunoglobulin delta-Chains

Immunoglobulin Switch Region

Immunoglobulin alpha-Chains

Dextrans

gamma-Globulins

Antibodies, Viral

Binding, Competitive

Molecular Sequence Data

Autoantigens

Secretory Component

Serum Albumin, Bovine

Agammaglobulinemia