Immunoglobulins, Intravenous: Immunoglobulin preparations used in intravenous infusion, containing primarily IMMUNOGLOBULIN G. They are used to treat a variety of diseases associated with decreased or abnormal immunoglobulin levels including pediatric AIDS; primary HYPERGAMMAGLOBULINEMIA; SCID; CYTOMEGALOVIRUS infections in transplant recipients, LYMPHOCYTIC LEUKEMIA, CHRONIC; Kawasaki syndrome, infection in neonates, and IDIOPATHIC THROMBOCYTOPENIC PURPURA.Immunization, Passive: Transfer of immunity from immunized to non-immune host by administration of serum antibodies, or transplantation of lymphocytes (ADOPTIVE TRANSFER).Encyclopedias as Topic: Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)Receptors, IgG: Specific molecular sites on the surface of various cells, including B-lymphocytes and macrophages, that combine with IMMUNOGLOBULIN Gs. Three subclasses exist: Fc gamma RI (the CD64 antigen, a low affinity receptor), Fc gamma RII (the CD32 antigen, a high affinity receptor), and Fc gamma RIII (the CD16 antigen, a low affinity receptor).Immunoglobulins: Multi-subunit proteins which function in IMMUNITY. They are produced by B LYMPHOCYTES from the IMMUNOGLOBULIN GENES. They are comprised of two heavy (IMMUNOGLOBULIN HEAVY CHAINS) and two light chains (IMMUNOGLOBULIN LIGHT CHAINS) with additional ancillary polypeptide chains depending on their isoforms. The variety of isoforms include monomeric or polymeric forms, and transmembrane forms (B-CELL ANTIGEN RECEPTORS) or secreted forms (ANTIBODIES). They are divided by the amino acid sequence of their heavy chains into five classes (IMMUNOGLOBULIN A; IMMUNOGLOBULIN D; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M) and various subclasses.Immunoglobulin G: The major immunoglobulin isotype class in normal human serum. There are several isotype subclasses of IgG, for example, IgG1, IgG2A, and IgG2B.Actinobacillus suis: A species of gram-negative bacteria in the genus ACTINOBACILLUS. It is mainly a pathogen of PIGS, but also can infect HORSES.Mice, Hairless: Mutant strains of mice that produce little or no hair.Immunoglobulin A: Represents 15-20% of the human serum immunoglobulins, mostly as the 4-chain polymer in humans or dimer in other mammals. Secretory IgA (IMMUNOGLOBULIN A, SECRETORY) is the main immunoglobulin in secretions.Immunoglobulin M: A class of immunoglobulin bearing mu chains (IMMUNOGLOBULIN MU-CHAINS). IgM can fix COMPLEMENT. The name comes from its high molecular weight and originally being called a macroglobulin.Pemphigoid, Benign Mucous Membrane: A chronic blistering disease with predilection for mucous membranes and less frequently the skin, and with a tendency to scarring. It is sometimes called ocular pemphigoid because of conjunctival mucous membrane involvement.Saliva: The clear, viscous fluid secreted by the SALIVARY GLANDS and mucous glands of the mouth. It contains MUCINS, water, organic salts, and ptylin.Immunoglobulin E: An immunoglobulin associated with MAST CELLS. Overexpression has been associated with allergic hypersensitivity (HYPERSENSITIVITY, IMMEDIATE).Allergens: Antigen-type substances that produce immediate hypersensitivity (HYPERSENSITIVITY, IMMEDIATE).Hypersensitivity: Altered reactivity to an antigen, which can result in pathologic reactions upon subsequent exposure to that particular antigen.Skin Tests: Epicutaneous or intradermal application of a sensitizer for demonstration of either delayed or immediate hypersensitivity. Used in diagnosis of hypersensitivity or as a test for cellular immunity.Hypersensitivity, Immediate: Hypersensitivity reactions which occur within minutes of exposure to challenging antigen due to the release of histamine which follows the antigen-antibody reaction and causes smooth muscle contraction and increased vascular permeability.Desensitization, Immunologic: Immunosuppression by the administration of increasing doses of antigen. Though the exact mechanism is not clear, the therapy results in an increase in serum levels of allergen-specific IMMUNOGLOBULIN G, suppression of specific IgE, and an increase in suppressor T-cell activity.Asthma: A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).Encephalomalacia: Softening or loss of brain tissue following CEREBRAL INFARCTION; cerebral ischemia (see BRAIN ISCHEMIA), infection, CRANIOCEREBRAL TRAUMA, or other injury. The term is often used during gross pathologic inspection to describe blurred cortical margins and decreased consistency of brain tissue following infarction. Multicystic encephalomalacia refers to the formation of multiple cystic cavities of various sizes in the cerebral cortex of neonates and infants following injury, most notably perinatal hypoxia-ischemic events. (From Davis et al., Textbook of Neuropathology, 2nd ed, p665; J Neuropathol Exp Neurol, 1995 Mar;54(2):268-75)IgA Deficiency: A dysgammaglobulinemia characterized by a deficiency of IMMUNOGLOBULIN A.Dysgammaglobulinemia: An immunologic deficiency state characterized by selective deficiencies of one or more, but not all, classes of immunoglobulins.Agammaglobulinemia: An immunologic deficiency state characterized by an extremely low level of generally all classes of gamma-globulin in the blood.IgG Deficiency: A dysgammaglobulinemia characterized by a deficiency of IMMUNOGLOBULIN G.Immunologic Deficiency Syndromes: Syndromes in which there is a deficiency or defect in the mechanisms of immunity, either cellular or humoral.Dictionaries, MedicalMeasles: A highly contagious infectious disease caused by MORBILLIVIRUS, common among children but also seen in the nonimmune of any age, in which the virus enters the respiratory tract via droplet nuclei and multiplies in the epithelial cells, spreading throughout the MONONUCLEAR PHAGOCYTE SYSTEM.Measles virus: The type species of MORBILLIVIRUS and the cause of the highly infectious human disease MEASLES, which affects mostly children.Measles Vaccine: A live attenuated virus vaccine of chick embryo origin, used for routine immunization of children and for immunization of adolescents and adults who have not had measles or been immunized with live measles vaccine and have no serum antibodies against measles. Children are usually immunized with measles-mumps-rubella combination vaccine. (From Dorland, 28th ed)Dictionaries as Topic: Lists of words, usually in alphabetical order, giving information about form, pronunciation, etymology, grammar, and meaning.Crowdsourcing: Social media model for enabling public involvement and recruitment in participation. Use of social media to collect feedback and recruit volunteer subjects.Terminology as Topic: The terms, expressions, designations, or symbols used in a particular science, discipline, or specialized subject area.Rho(D) Immune Globulin: Immunizing agent containing IMMUNOGLOBULIN G anti-Rho(D) used for preventing Rh immunization in Rh-negative individuals exposed to Rh-positive red blood cells.Electronic Mail: Messages between computer users via COMPUTER COMMUNICATION NETWORKS. This feature duplicates most of the features of paper mail, such as forwarding, multiple copies, and attachments of images and other file types, but with a speed advantage. The term also refers to an individual message sent in this way.Rh Isoimmunization: The process by which fetal Rh+ erythrocytes enter the circulation of an Rh- mother, causing her to produce IMMUNOGLOBULIN G antibodies, which can cross the placenta and destroy the erythrocytes of Rh+ fetuses. Rh isoimmunization can also be caused by BLOOD TRANSFUSION with mismatched blood.Erythroblastosis, Fetal: A condition characterized by the abnormal presence of ERYTHROBLASTS in the circulation of the FETUS or NEWBORNS. It is a disorder due to BLOOD GROUP INCOMPATIBILITY, such as the maternal alloimmunization by fetal antigen RH FACTORS leading to HEMOLYSIS of ERYTHROCYTES, hemolytic anemia (ANEMIA, HEMOLYTIC), general edema (HYDROPS FETALIS), and SEVERE JAUNDICE IN NEWBORN.Rh-Hr Blood-Group System: Erythrocyte isoantigens of the Rh (Rhesus) blood group system, the most complex of all human blood groups. The major antigen Rh or D is the most common cause of erythroblastosis fetalis.Fetomaternal Transfusion: Transplacental passage of fetal blood into the circulation of the maternal organism. (Dorland, 27th ed)Abortion, Threatened: UTERINE BLEEDING from a GESTATION of less than 20 weeks without any CERVICAL DILATATION. It is characterized by vaginal bleeding, lower back discomfort, or midline pelvic cramping and a risk factor for MISCARRIAGE.Common Variable Immunodeficiency: Heterogeneous group of immunodeficiency syndromes characterized by hypogammaglobulinemia of most isotypes, variable B-cell defects, and the presence of recurrent bacterial infections.Immunoglobulin Heavy Chains: The largest of polypeptide chains comprising immunoglobulins. They contain 450 to 600 amino acid residues per chain, and have molecular weights of 51-72 kDa.Receptors, Polymeric Immunoglobulin: Specialized Fc receptors (RECEPTORS, FC) for polymeric immunoglobulins, which mediate transcytosis of polymeric IMMUNOGLOBULIN A and IMMUNOGLOBULIN M into external secretions. They are found on the surfaces of epithelial cells and hepatocytes. After binding to IMMUNOGLOBULIN A, the receptor-ligand complex undergoes endocytosis, transport by vesicle, and secretion into the lumen by exocytosis. Before release, the part of the receptor (SECRETORY COMPONENT) that is bound to IMMUNOGLOBULIN A is proteolytically cleaved from its transmembrane tail. (From Rosen et al., The Dictionary of Immunology, 1989)Secretory Component: The extracellular moiety of the POLYMERIC IMMUNOGLOBULIN RECEPTOR found alone or complexed with IGA or IGM, in a variety of external secretions (tears, bile, colostrum.) Secretory component is derived by proteolytic cleavage of the receptor during transcytosis. When immunoglobulins IgA and IgM are bound to the receptor, during their transcytosis secretory component becomes covalently attached to them generating SECRETORY IMMUNOGLOBULIN A or secretory IMMUNOGLOBULIN M.Immunoglobulin A, Secretory: The principle immunoglobulin in exocrine secretions such as milk, respiratory and intestinal mucin, saliva and tears. The complete molecule (around 400 kD) is composed of two four-chain units of IMMUNOGLOBULIN A, one SECRETORY COMPONENT and one J chain (IMMUNOGLOBULIN J-CHAINS).Epithelial Cells: Cells that line the inner and outer surfaces of the body by forming cellular layers (EPITHELIUM) or masses. Epithelial cells lining the SKIN; the MOUTH; the NOSE; and the ANAL CANAL derive from ectoderm; those lining the RESPIRATORY SYSTEM and the DIGESTIVE SYSTEM derive from endoderm; others (CARDIOVASCULAR SYSTEM and LYMPHATIC SYSTEM) derive from mesoderm. Epithelial cells can be classified mainly by cell shape and function into squamous, glandular and transitional epithelial cells.Plasma Cells: Specialized forms of antibody-producing B-LYMPHOCYTES. They synthesize and secrete immunoglobulin. They are found only in lymphoid organs and at sites of immune responses and normally do not circulate in the blood or lymph. (Rosen et al., Dictionary of Immunology, 1989, p169 & Abbas et al., Cellular and Molecular Immunology, 2d ed, p20)Genes, Immunoglobulin: Genes encoding the different subunits of the IMMUNOGLOBULINS, for example the IMMUNOGLOBULIN LIGHT CHAIN GENES and the IMMUNOGLOBULIN HEAVY CHAIN GENES. The heavy and light immunoglobulin genes are present as gene segments in the germline cells. The completed genes are created when the segments are shuffled and assembled (B-LYMPHOCYTE GENE REARRANGEMENT) during B-LYMPHOCYTE maturation. The gene segments of the human light and heavy chain germline genes are symbolized V (variable), J (joining) and C (constant). The heavy chain germline genes have an additional segment D (diversity).Drug Labeling: Use of written, printed, or graphic materials upon or accompanying a drug container or wrapper. It includes contents, indications, effects, dosages, routes, methods, frequency and duration of administration, warnings, hazards, contraindications, side effects, precautions, and other relevant information.Drug Repositioning: The deliberate and methodical practice of finding new applications for existing drugs.Product Labeling: Use of written, printed, or graphic materials upon or accompanying a product or its container or wrapper. It includes purpose, effect, description, directions, hazards, warnings, and other relevant information.United States Food and Drug Administration: An agency of the PUBLIC HEALTH SERVICE concerned with the overall planning, promoting, and administering of programs pertaining to maintaining standards of quality of foods, drugs, therapeutic devices, etc.Prescription Drugs: Drugs that cannot be sold legally without a prescription.Search Engine: Software used to locate data or information stored in machine-readable form locally or at a distance such as an INTERNET site.
The role of colorstrum on the occurrence of immunoglobulin G subclasses and antibody production in neonatal goats. (1/23942)
Quantitative determinations of IgG1 and IgG2, in one group of colostrum-fed and one group of colostrum-deprived neonatal goats revealed that the occurrence of the IgG1 subclass preceeded that of the IgG2 in both cases. In the colostrum-fed animals the IgG2 appeared, on an average, in the fourth week of life whereas in the colostrum-deprived animals the IgG2 was detected as early as three weeks after birth. At the age of twelve weeks the mean concentrations for IgG, and IgG2 were higher in the animals deprived of colostrum. The immune response to human gamma globulin was studied in colostrum-fed and colostrum-deprived neonatal goats which were immunized at birth and again after four and eight weeks. Following the first two antigen administrations a significantly higher response was obtained in the colostrum-fed neonates. However, the third injection determined a similar response in both groups. A marked suppressive effect on the immune response was observed in colostrum-fed neonatal goats when specific antibodies were present in the colostrum after preimmunization of the mothers with human gamma globulin. (+info)Features of the immune response to DNA in mice. I. Genetic control. (2/23942)
The genetic control of the immune response to DNA was studied in various strains of mice F1 hybrids and corresponding back-crosses immunized with single stranded DNA complexed to methylated bovine serum albumin. Anti-DNA antibody response was measured by radioimmuno-logical technique. High responder, low responder, and intermediate responder strains were found and the ability to respond to DNA was characterized as a dominant genetic trait which is not linked to the major locus of histocompatibility. Studies in back-crosses suggested that this immune response is under multigenic control. High responder mice produce both anti-double stranded DNA and anti-single stranded DNA 7S and 19S antibodies, while low responder mice produce mainly anti-single stranded DNA 19S antibodies. (+info)VEGF is required for growth and survival in neonatal mice. (3/23942)
We employed two independent approaches to inactivate the angiogenic protein VEGF in newborn mice: inducible, Cre-loxP- mediated gene targeting, or administration of mFlt(1-3)-IgG, a soluble VEGF receptor chimeric protein. Partial inhibition of VEGF achieved by inducible gene targeting resulted in increased mortality, stunted body growth and impaired organ development, most notably of the liver. Administration of mFlt(1-3)-IgG, which achieves a higher degree of VEGF inhibition, resulted in nearly complete growth arrest and lethality. Ultrastructural analysis documented alterations in endothelial and other cell types. Histological and biochemical changes consistent with liver and renal failure were observed. Endothelial cells isolated from the liver of mFlt(1-3)-IgG-treated neonates demonstrated an increased apoptotic index, indicating that VEGF is required not only for proliferation but also for survival of endothelial cells. However, such treatment resulted in less significant alterations as the animal matured, and the dependence on VEGF was eventually lost some time after the fourth postnatal week. Administration of mFlt(1-3)-IgG to juvenile mice failed to induce apoptosis in liver endothelial cells. Thus, VEGF is essential for growth and survival in early postnatal life. However, in the fully developed animal, VEGF is likely to be involved primarily in active angiogenesis processes such as corpus luteum development. (+info)Interaction of inflammatory cells and oral microorganisms. III. Modulation of rabbit polymorphonuclear leukocyte hydrolase release response to Actinomyces viscosus and Streptococcus mutans by immunoglobulins and complement. (4/23942)
In the absence of antiserum, rabbit polymorphonuclear leukocytes (PMNs) released lysosomal enzymes in response to Actinomyces viscosus (19246) but not to Streptococcus mutans (6715). Antibodies had a marked modulating influence on these reactions. PMN hydrolase release was significantly enhanced to both organisms when specific rabbit antiserum and isolated immunoglobulin G (IgG) were included in the incubations. Immune complex F(ab')2 fragments of IgG directed against S. mutans agglutinated bacteria. Immune complexes consisting of S. mutans and F(ab')2 fragments of IgG directed against this organism were not effective as bacteria-IgG complexes in stimulating PMN release. The intensity of the release response to bacteria-IgG complexes was also diminished when PMNs were preincubated with isolated Fc fragments derived from IgG. Fresh serum as a source of complement components had no demonstrable effect on PMN release either alone or in conjuction with antiserum in these experiments. These data may be relevant to the mechanisms and consequences of the interaction of PMNs and plaque bacteria in the pathogenesis of periodontal disease. (+info)Prevention of collagen-induced arthritis by gene delivery of soluble p75 tumour necrosis factor receptor. (5/23942)
Collagen type II-induced arthritis (CIA) in DBA/1 mice can be passively transferred to SCID mice with spleen B- and T-lymphocytes. In the present study, we show that infection ex vivo of splenocytes from arthritic DBA/1 mice with a retroviral vector, containing cDNA for the soluble form of human p75 receptor of tumour necrosis factor (TNF-R) before transfer, prevents the development of arthritis, bone erosion and joint inflammation in the SCID recipients. Assessment of IgG subclass levels and studies of synovial histology suggest that down-regulating the effector functions of T helper-type 1 (Th1) cells may, at least in part, explain the inhibition of arthritis in the SCID recipients. In contrast, the transfer of splenocytes infected with mouse TNF-alpha gene construct resulted in exacerbated arthritis and enhancement of IgG2a antibody levels. Intriguingly, infection of splenocytes from arthritic DBA/1 mice with a construct for mouse IL-10 had no modulating effect on the transfer of arthritis. The data suggest that manipulation of the immune system with cytokines, or cytokine inhibitors using gene transfer protocols can be an effective approach to ameliorate arthritis. (+info)Variable domain-linked oligosaccharides of a human monoclonal IgG: structure and influence on antigen binding. (6/23942)
The variable-domain-attached oligosaccharide side chains of a human IgG produced by a human-human-mouse heterohybridoma were analysed. In addition to the conserved N-glycosylation site at Asn-297, an N-glycosylation consensus sequence (Asn-Asn-Ser) is located at position 75 in the variable region of its heavy chain. The antibody was cleaved into its antigen-binding (Fab) and crystallizing fragments. The oligosaccharides of the Fab fragment were released by digestion with various endo- and exoglycosidases and analysed by anion-exchange chromatography and fluorophore-assisted carbohydrate electrophoresis. The predominant components were disialyl- bi-antennary and tetra-sialyl tetra-antennary complex carbohydrates. Of note is the presence in this human IgG of oligosaccharides containing N-glycolylneuraminic acid and N-acetylneuraminic acid in the ratio of 94:6. Furthermore, we determined N-acetylgalactosamine in the Fab fragment of this antibody, suggesting the presence of O-linked carbohydrates. A three-dimensional structure of the glycosylated variable (Fv) fragment was suggested using computer-assisted modelling. In addition, the influence of the Fv-associated oligosaccharides of the CBGA1 antibody on antigen binding was tested in several ELISA systems. Deglycosylation resulted in a decreased antigen-binding activity. (+info)Zonula occludens toxin is a powerful mucosal adjuvant for intranasally delivered antigens. (7/23942)
Zonula occludens toxin (Zot) is produced by toxigenic strains of Vibrio cholerae and has the ability to reversibly alter intestinal epithelial tight junctions, allowing the passage of macromolecules through the mucosal barrier. In the present study, we investigated whether Zot could be exploited to deliver soluble antigens through the nasal mucosa for the induction of antigen-specific systemic and mucosal immune responses. Intranasal immunization of mice with ovalbumin (Ova) and recombinant Zot, either fused to the maltose-binding protein (MBP-Zot) or with a hexahistidine tag (His-Zot), induced anti-Ova serum immunoglobulin G (IgG) titers that were approximately 40-fold higher than those induced by immunization with antigen alone. Interestingly, Zot also stimulated high anti-Ova IgA titers in serum, as well as in vaginal and intestinal secretions. A comparison with Escherichia coli heat-labile enterotoxin (LT) revealed that the adjuvant activity of Zot was only sevenfold lower than that of LT. Moreover, Zot and LT induced similar patterns of Ova-specific IgG subclasses. The subtypes IgG1, IgG2a, and IgG2b were all stimulated, with a predominance of IgG1 and IgG2b. In conclusion, our results highlight Zot as a novel potent mucosal adjuvant of microbial origin. (+info)The levels and bactericidal capacity of antibodies directed against the UspA1 and UspA2 outer membrane proteins of Moraxella (Branhamella) catarrhalis in adults and children. (8/23942)
The UspA1 and UspA2 proteins from Moraxella catarrhalis share antigenic epitopes and are promising vaccine candidates. In this study, the levels and bactericidal activities of antibodies in sera from healthy adults and children toward UspA1 and UspA2 from the O35E strain were measured. Human sera contained antibodies to both proteins, and the levels of immunoglobulin G (IgG) antibodies were age dependent. Adult sera had significantly higher titers of IgG than child sera (P < 0.01). The IgG3 titers to the UspA proteins were higher than the IgG1 titers in the adults' sera, while the IgG1 titers were higher than the IgG3 titers in the children's sera (P < 0.05). The IgG antibodies in the sera from 2-month-old children appeared to be maternally derived, since the mean titer was significantly higher than that in sera from 6- to 7-month-old children (P < 0.05). Serum IgA antibodies to both UspA1 and UspA2 were low during the first 7 months of age but thereafter gradually increased along with the IgG titers. Analysis of sera absorbed with UspA1 or UspA2 showed that the antibodies to UspA1 and UspA2 were cross-reactive with each other and associated with serum bactericidal activity. Examination of affinity-purified human antibodies confirmed that naturally acquired antibodies to UspA1 and UspA2 were bactericidal and cross-reactive. These results support using UspA1 and UspA2 in a vaccine to prevent M. catarrhalis infections. (+info)
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IGSF1 immunoglobulin superfamily member 1 [Homo sapiens (human)] - Gene - NCBI
What do elevated immunoglobulin levels mean? | Reference.com
IV Immunoglobulin May Protect Against Alzheimer's | Medpage Today
Antenatal intravenous immunoglobulin in c... & related info | Mendeley
Intravenous Immunoglobulin (IVIg) Treatment May Benefit Some Children with Autism Spectrum Disorder
Intravenous immunoglobulin for Guillain-Barré syndrome
Rh immunoglobulin - Medical Dictionary / Glossary | Medindia
Intravenous immunoglobulin and the kidney--a two-edged sword. - PubMed - NCBI
Immunoglobulin E: Pathogenic Relevance in Immediate Contact Reactions | SpringerLink
Rapid Global Characterization of Immunoglobulin G1 following Oxidative Stress
Colostral Immunoglobulin Absorption in Intubated and Bottle-fed Calves - Aberra Molla - Google Books
Immunoglobulin A
Intravenous Immunoglobulin (IVIG): uses & side-effects | PatientsLikeMe
Intravenous Immunoglobulin (IVIG): uses & side-effects | PatientsLikeMe
Immunoglobulin A Nephropathy - definition of Immunoglobulin A Nephropathy by The Free Dictionary
Cloning immunoglobulin variable domains for expression by the polymerase chain reaction | PNAS
Evaluation of commercially available anti-dengue virus immunoglobulin M tests
JCI -
Immunoglobulin light chains generate proinflammatory and profibrotic kidney injury
RCSB PDB
- 1AR2: DISULFIDE-FREE IMMUNOGLOBULIN FRAGMENT Macromolecule Annotations Page
RCSB PDB - Gene View
- LILRB1 - leukocyte immunoglobulin like receptor B1
Serological Immunoglobulin-Free Light Chain Profile in Myasthenia Gravis Patients
Global Immunoglobulin Market Size 2017 Industry Trend and Forecast... - QYResearch
Immunoglobulin A and Gliadin IGA high - Celiac.com
Mouse Immunoglobulin Chromogenic Kit, WesternBreeze Chromogenic from Invitrogen
immunoglobulin superfamily, member 10 Biomolecules | Biocompare
Which dietary modifications are used in the treatment of immunoglobulin A (IgA) neuropathy?
Anti-immunoglobulin stimulation of B lymphocytes activates src-related protein-tyrosine kinases. | PNAS
Primary Sclerosing Cholangitis Associated with Elevated Immunoglobulin-G4: A Preliminary Study
Intravenous Immunoglobulin After Relapse in Vasculitis - Full Text View - ClinicalTrials.gov
Intravenous Immunoglobulin Therapy in Optic Neuritis - Full Text View - ClinicalTrials.gov
Immunoglobulins devoid of light chains - Vrije, Universiteit Brussel
immunoglobulin | The ME Association
Gut microbiota utilize immunoglobulin A for mucosal colonization | Science
Food Allergy: Immunoglobulin E-mediated | GreenMedInfo | Disease
intravenous immunoglobulin | Journal of Neurology, Neurosurgery & Psychiatry
False-Positive Results with a Commercially Available West Nile Virus Immunoglobulin M Assay --- United States, 2008
Immunoglobulins comprising predominantly a GlcNAc2Man3GlcNAc2 glycoform - Gerngross, Tillman U.
immunoglobulin m - definition and meaning
Immunoglobulin, IgG | Health Testing Centers
Immunoglobulin, IgM | Health Testing Centers
Immunoglobulin Transport to the Neonate - Module 5: Mother & Neonate | Coursera
Maternal Immunoglobulin E and Childhood Leukemia | Cancer Epidemiology, Biomarkers & Prevention
Immunoglobulin: A Natural Way to Suppress Helicobacter pylori in Humans
Bovine x mouse hybridomas that secrete bovine immunoglobulin G1 | Science
Purified Immunoglobulins - Sera and Immunoglobulins | Sigma-Aldrich
Normal Sera - Sera and Immunoglobulins | Sigma-Aldrich
Serum immunoglobulin profiles of septicemic versus healthy neonates.
Octagam intravenous immunoglobulin solutions | Therapeutic Goods Administration (TGA)
CSF Immunoglobulin G (IgG) Index: MedlinePlus Medical Test
Global Intravenous Immunoglobulin (IVIg) Market Research Report 2017
Interactions between Norethindrone Acetate-Ethinyl Estradiol Oral and estrogens-selected-human-immunoglobulins
Biomolecules | Free Full-Text | The Immunoglobulins of Cold-Blooded Vertebrates
Browsing Publications by Subject "Immunoglobulin M"
AntibodiesSerumSpecificityIsotypeIgG4IgG2HumanTissueIVIGProteinsSuperfamily memberMonoclonalIsotypesLight chainsNephropathyTherapyLevel of immunoglobulinEnzyme-linkeSerum immunoglobulinsQuantitativeHttpsMouse immunoglobulinNormal immunoglobulinReplacement immunoglobulinChainsGeneDeficiencyRabiesMiceAntigensType of antibodySubstancesIndicationsAutoimmune2017GlycoproteinsImmune systemComplement systemHumanAntigen specificBloodSecretionsFLCsAntibody responsesMeaslesDiseasesEfficacySecretory component
Antibodies1
- Bio-Rad offers a range of human immunoglobulin antibodies for the IgG isotype. (bio-rad-antibodies.com)
Serum2
- Human IgG (immunoglobulin G) is expressed on the surface of mature B cells and is the most prevalent Ig in serum and the major Ig in extravascular spaces. (bio-rad-antibodies.com)
- Secreted as part of the adaptive immune response by plasma B cells, immunoglobulin G constitutes 75% of serum immunoglobulins. (rockland-inc.com)
Specificity1
- When choosing a secondary antibody product, consideration must be given to species and immunoglobulin specificity, conjugate type, fragment and chain specificity, level of cross-reactivity, and host-species source and fragment composition. (rockland-inc.com)
Isotype1
- Properties E05 478 566 350 170 or Enzyme-Linked Immunosorbent Assays,E05 478 566 350 170 or Enzyme-Linked Immunosorbent Assays,Immunoglobulin E (IgE) kappa or Fc specific antibody is a kind of antibody (or immunoglobulin (Ig) "isotype") that has only been found in mammals. (gentaur.com)
IgG41
- Human immunoglobulin subclasses IgG1 and IgG3 tend to strongly bind fragment crystallization (Fc) receptors, whereas subclasses IgG2 and IgG4 bind weakly. (bio-rad-antibodies.com)
IgG21
- It should be noted, the human immunoglobulin subclass IgG2 does cross the placenta, but it does so weakly. (bio-rad-antibodies.com)
Human1
- IgG is also the only human immunoglobulin to pass from mother to fetus to transfer immunity. (bio-rad-antibodies.com)
Tissue1
- It is the most abundant immunoglobulin and is approximately equally distributed in blood and in tissue liquids, and is the class of immunoglobulin characterized by heavy chains. (leebio.com)
IVIG12
- Immunoglobulin Deficiency - Is ivig safe and how long do I have to use it? (drugs.com)
- IVIG (Intravenous immunoglobulin)? (drugs.com)
- OKLAHOMA CITY , Sept. 12, 2018 /PRNewswire/ -- A subset of children with autism spectrum disorder (ASD), who have an immune abnormality, may benefit from intravenous immunoglobulin (IVIg) treatment, according to new research from Richard E. Frye , MD, PhD, Chief of Neurodevelopmental Disorders at the Barrow Neurological Institute at Phoenix Children's Hospital. (prnewswire.com)
- Intravenous immunoglobulin (IVIg) is beneficial in other autoimmune diseases. (nih.gov)
- To review the literature on the use and efficacy of intravenous immunoglobulin (IVIG) in glomerulonephritis and to evaluate the nephrotoxic effect of IVIG. (nih.gov)
- To determine whether high-dose intravenous immunoglobulin (IVIg) is more effective than placebo in restoring lost visual function (visual acuity) in optic neuritis (ON). (clinicaltrials.gov)
- The TGA has become aware of reports of a markedly increased incidence of serious adverse reactions associated with Octagam, an intravenous immunoglobulin (IVIg) preparation, manufactured by Octapharma in Europe. (tga.gov.au)
- Brooklyn, NY -- ( SBWIRE ) -- 11/01/2017 -- QYResearchReports.com has announced the addition of a report titled, "Global Intravenous Immunoglobulin (IVIg) Market Research Report 2017" to its depository. (sbwire.com)
- The improvement in the production of IVIg on account of technological advancements is another key catalyst of the market for intravenous immunoglobulin. (sbwire.com)
- The exorbitant costs of IVIg technology might also emerge as another restraint of the market for intravenous immunoglobulin. (sbwire.com)
- Serum levels of immunoglobulin A, immunoglobulin M and immunoglobulin G will be quantified before and after IVIG-infusion. (knowcancer.com)
- So much so that he is sending him for intravenous immunoglobulin therapy (IVIG) thinking. (alsforums.com)
Proteins5
- A preparation containing immunoglobulin proteins, especially immune globulin. (yourdictionary.com)
- Proteins in this superfamily contain varying numbers of immunoglobulin-like domains and are thought to participate in the regulation of interactions between cells. (nih.gov)
- The immunoglobulin superfamily is a group of proteins, each made of one or several domains sharing key structural features with either the variable (V) or the constant (C) immunoglobulin domains. (nih.gov)
- A purified form of human immunoglobulin G and other proteins used to treat immunodeficiency and a wide variety of autoimmune disorders. (drugbank.ca)
- Immunoglobulin D ( IgD ) is an antibody isotype that makes up about 1% of proteins in the plasma membranes of immature B-lymphocytes where it is usually coexpressed with another cell surface antibody called IgM . (wikidoc.org)
Superfamily member1
- Your search returned 4 immunoglobulin superfamily, member 10 Biomolecules across 2 suppliers. (biocompare.com)
Monoclonal3
- Because of the less-than-robust response to therapy and impact on choice of optimal chemotherapy and prognosis, chronic kidney disease has drawn attention in the treatment of multiple myeloma, a malignant hematologic disorder that can produce significant amounts of monoclonal immunoglobulin free light chains (FLCs). (jci.org)
- To the extent that the experiments reflect the human condition, these studies offer insights into the pathogenesis of progressive kidney failure in the setting of lymphoproliferative disorders, such as multiple myeloma, that feature increased circulating levels of monoclonal immunoglobulin fragments that require metabolism by the kidney. (jci.org)
- A monoclonal anti-immunoglobulin E antibody used in the treatment of severe asthma and chronic idiopathic urticaria. (drugbank.ca)
Isotypes1
- Low levels of immunoglobulins (isotypes or subclasses), without impaired antigen-specific IgG antibody responses, do not indicate a need for immunoglobulin replacement therapy. (choosingwisely.org)
Light chains4
- Immunoglobulins include light chains and heavy chains. (wikipedia.org)
- Each immunoglobulin molecules is a tetramer of two identical light chains and two identical heavy chains linked by disulfide bonds. (uniprot.org)
- Serological levels of free immunoglobulin light chains (FLCs), produced in excess of heavy chains during synthesis of immunoglobulins by plasma cells, can be considered a direct marker of B cell activity in different systemic inflammatory-autoimmune conditions and may represent a useful predictor of rituximab (RTX) therapeutic efficacy, as reported for rheumatoid arthritis and systemic lupus erythematosus. (hindawi.com)
- They are comprised of two heavy (IMMUNOGLOBULIN HEAVY CHAINS) and two light chains (IMMUNOGLOBULIN LIGHT CHAINS) with additional ancillary polypeptide chains depending on their isoforms. (drugbank.ca)
Nephropathy5
- What is immunoglobulin A (IgA) nephropathy? (medscape.com)
- Immunoglobulin A (IgA) nephropathy is characterized by predominant IgA deposition in the glomerular mesangium. (medscape.com)
- Light microscopy of a glomerulus from a patient with immunoglobulin A nephropathy showing increased mesangial matrix and cellularity. (medscape.com)
- Immunofluorescence microscopy demonstrating large mesangial immunoglobulin A (IgA) deposits diagnostic of IgA nephropathy. (medscape.com)
- Immunoglobulin A nephropathy: a pathophysiology view. (medscape.com)
Therapy9
- Human immunoglobulin therapy first occurred in the 1930s and a formulation for injection into a vein was approved for medical use in the United States in 1981. (wikipedia.org)
- Immunoglobulin therapy is also used for a number of other conditions, including in many autoimmune disorders such as dermatomyositis in an attempt to decrease the severity of symptoms. (wikipedia.org)
- Immunoglobulin therapy is also used in some treatment protocols for secondary immunodeficiencies such as human immunodeficiency virus (HIV), some autoimmune disorders (such as immune thrombocytopenia and Kawasaki disease ), some neurological diseases ( multifocal motor neuropathy , stiff person syndrome , multiple sclerosis and myasthenia gravis ) some acute infections and some complications of organ transplantation. (wikipedia.org)
- Immunoglobulin therapy is especially useful in some acute infection cases such as pediatric HIV infection and is also considered the standard of treatment for some autoimmune disorders such as Guillain-Barré syndrome . (wikipedia.org)
- Different national bodies and medical associations have established varying standards for the use of immunoglobulin therapy. (wikipedia.org)
- The National Advisory Committee on Blood and Blood Products of Canada (NAC) and Canadian Blood Services have also developed their own separate set of guidelines for the appropriate use of immunoglobulin therapy, which strongly support the use of immunoglobulin therapy in primary immunodeficiencies and some complications of HIV, while remaining silent on the issues of sepsis, multiple sclerosis, and chronic fatigue syndrome. (wikipedia.org)
- In November 2011, the IDF Medical Advisory Committee wrote a resolution regarding formulary changes that limit a physician's ability to determine the most appropriate immunoglobulin replacement therapy. (primaryimmune.org)
- Don't recommend replacement immunoglobulin therapy for recurrent infections unless impaired antibody responses to vaccines are demonstrated. (choosingwisely.org)
- Measurement of IgG subclasses is not routinely useful in determining the need for immunoglobulin therapy. (choosingwisely.org)
Level of immunoglobulin1
- The IgG test is used to measure the level of immunoglobulin G in the body. (healthtestingcenters.com)
Enzyme-linke2
- Evaluation of Immunoglobulin A-capture Enzyme-linked Immunosorbent Assay for Serodiagnosis of Dengue Virus Infection. (who.int)
- In September 2008, CDC, the Food and Drug Administration (FDA), and state health departments began a nationwide investigation into an increase in false-positive test results obtained with a commercially available West Nile virus (WNV) immunoglobulin M (IgM) capture enzyme-linked immunosorbent assay (ELISA). (cdc.gov)
Serum immunoglobulins2
- Cultures of blood were done and serum immunoglobulins (IgG, IgA) were estimated in all the subjects. (biomedsearch.com)
- Represents 15-20% of the human serum immunoglobulins, mostly as the 4-chain polymer in humans or dimer in other mammals. (jove.com)
Quantitative2
- The Immunoglobulin E (IgE) ELISA Kit is for the quantitative determination of IgE in human serum. (mpbio.com)
- Loh RK, Vale S, Maclean-Tooke A. Quantitative serum immunoglobulin tests. (medlineplus.gov)
Https1
- Retrieved on May 22, 2019 from https://www.news-medical.net/health/Antibody-Immunoglobulin-Diversity.aspx. (news-medical.net)
Mouse immunoglobulin1
- We have designed a set of oligonucleotide primers to amplify the cDNA of mouse immunoglobulin heavy and light chain variable domains by the polymerase chain reaction. (pnas.org)
Normal immunoglobulin2
- The V domains of normal immunoglobulin are highly heterogeneous, reflecting their role in protecting against the great variety of infectious microbes, and this heterogeneity impeded detailed structural analysis of IgM. (wikipedia.org)
- Normal immunoglobulin E, or IgE, levels in children are 10 international units per milliliter for 1-year-olds. (reference.com)
Replacement immunoglobulin1
- Restricting access of subscribers to only one or two product/formulations of replacement immunoglobulin regardless of the particular product the patient may currently be receiving poses an unjustified safety risk for patients. (primaryimmune.org)
Chains2
- as such, the molecular weight of slgA is 385,000D. One of these is the J chain (joining chain), which is a polypeptide of molecular mass 15kD, rich with cysteine and structurally completely different from other immunoglobulin chains. (wikipedia.org)
- There is provided an isolated immunoglobulin comprising two heavy polypeptide chains sufficient for the formation of a complete antigen binding site or several antigen binding sites, wherein the immunoglobulin is further devoid of light polypeptide chains. (freepatentsonline.com)
Gene2
- [ 7 ] The absence of IgM in the presence of normal levels of immunoglobulin G (IgG) and immunoglobulin A (IgA) has yet to be explained, as this appears to contradict the theory of sequential immunoglobulin gene rearrangement. (medscape.com)
- This gene encodes a member of the immunoglobulin-like domain-containing superfamily. (nih.gov)
Deficiency6
- Immunoglobulin Deficiency - symptoms of deficiency? (drugs.com)
- Most people with selective IgA (immunoglobulin) deficiency have no symptoms. (drugs.com)
- Immunoglobulin D (IgD) deficiency is a defect of humoral immunity that is characterized by abnormally low serum levels of IgD immunoglobulins. (medscape.com)
- Selective immunoglobulin M (SIgM) deficiency is a rare form of dysgammaglobulinemia characterized by an isolated low level of serum immunoglobulin M (IgM). (medscape.com)
- Serum immunoglobulin levels are controlled by intricate immunological regulatory mechanisms, and heterogeneity is believed to exist in the pathogenesis of SIgM deficiency. (medscape.com)
- Selective IgA deficiency is not an indication for administration of immunoglobulin. (choosingwisely.org)
Rabies10
- A number of specific immunoglobulin formulations are also available including for hepatitis B , rabies , tetanus , varicella infection , and Rh positive blood exposure . (wikipedia.org)
- The disease is preventable if exposed persons receive timely postexposure prophylaxis (PEP), which includes human rabies immunoglobulin and 4 doses of inactivated rabies vaccine administered over 14 days (4). (thefreedictionary.com)
- Tenders are invited for Equine Rabies Immunoglobulin 300 I. (thefreedictionary.com)
- Around 90% of the population received antirabies vaccination but only a few were administered rabies immunoglobulin despite 70% of the category III wounds victims. (thefreedictionary.com)
- There was no history suggestive of Rabies immunoglobulin administration at the wound site at that time. (thefreedictionary.com)
- Bringing down the cost of human rabies vaccines and treatments will require strong international collaboration to make quality-assured vaccines and rabies immunoglobulin available to health centres in regions where rabies is endemic. (thefreedictionary.com)
- 3) Which method was used to investigate rabies immunoglobulin in the cerebrospinal fluid? (thefreedictionary.com)
- shows that bites should be graded according to severity, and vaccine and/or rabies immunoglobulin (which is expensive) administered accordingly. (thefreedictionary.com)
- US military policy advised that rabies PEP should adhere to World Health Organization guidelines (10), which recommend giving human rabies immunoglobulin plus 5 doses of rabies vaccine. (thefreedictionary.com)
- Rabies post-exposure prophylaxis (PEP) was required following the national guidelines, so the patient received Purified Vero cell rabies vaccine (PVRV) and human rabies immunoglobulin (HRIG, 20 IU/Kg). (thefreedictionary.com)
Mice1
- We found that a regulatory system in the prominent human commensal Bacteroides fragilis modulates its surface architecture to invite binding of immunoglobulin A (IgA) in mice. (sciencemag.org)
Antigens5
- The molecular structures that microbes present to the immune system and elicit immunoglobulin (antibody) production are collectively denoted as antigens. (wikipedia.org)
- different V domains bind different antigens, i.e., binding of antigen by immunoglobulin is antigen specific. (wikipedia.org)
- Tenders are invited for reagents for the determination of TORCH infections, hepatitis, parasites ELISA: A set of reagents for the detection of immunoglobulin G antigens opistorhysiv, Trichinella, Echinococcus and toxocara serum (plasma) of human blood by ELISA. (thefreedictionary.com)
- 17. The pharmaceutical composition of claim 14, wherein said immunoglobulins comprise an antibody which binds to an antigen selected from the group consisting of growth factors, FGFR, EGFR, VEGF, leukocyte antigens, CD20, CD33, cytokines, TNF-α and TNF-β. (freepatentsonline.com)
- As one of the 5 immunoglobulins found in the blood, it is a long-lasting defense against most antigens. (healthtestingcenters.com)
Type of antibody1
- Immunoglobulin G (IgG) is a type of antibody. (wikipedia.org)
Substances1
- Your body makes different types of immunoglobulins to fight different types of these substances. (medlineplus.gov)
Indications1
- Overall, 2% of patients who had received IV immunoglobulin for various indications were affected, compared with 4.1% of controls who had not received the treatment ( P =0.002), Howard Fillit, MD, of Mount Sinai School of Medicine in New York, and colleagues reported in the July 21 issue of Neurology . (medpagetoday.com)
Autoimmune2
- As the number of patients suffering from pathological conditions and autoimmune diseases has been escalating by the day, the global demand for intravenous immunoglobulin is expected to multiply. (sbwire.com)
- Lupus, celiac disease, and juvenile idiopathic arthritis are some autoimmune conditions that are diagnosed via intravenous immunoglobulin tests. (sbwire.com)
20172
- Global Immunoglobulin Market Size 2017 Industry Trend and Forecast. (mynewsdesk.com)
- The Global And China Immunoglobulin Industry 2017 Market Research Report is a professional and in-depth study on the current state of the Immunoglobulin industry. (mynewsdesk.com)
Glycoproteins1
- Immunoglobulins (Igs) are glycoproteins. (chegg.com)
Immune system2
- Binding of the immunoglobulins to a microbe can have immediate effects such as blocking invasion and it can mobilize other components of the immune system to destroy or otherwise inactivate the microbes, thereby providing protection against infectious diseases. (wikipedia.org)
- Allergic (extrinsic) asthma is associated with immunoglobulin E (IgE)-an antibody generated by the immune system, in this case, in response to a normally harmless substance. (verywellhealth.com)
Complement system2
- The immunoglobulin C domains interact with other physiological components, eg cellular immunoglobulin receptors and the complement system. (wikipedia.org)
- Thus, the constant domain of an immunoglobulin can help mobilize phagocytic cells or the complement system to act on an antigen to which it is bound by via variable domain. (wikipedia.org)
Human6
- Human immunoglobulin is made from human blood plasma . (wikipedia.org)
- Immunoglobulin (also called gamma globulin or immune globulin) is a substance made from human blood plasma. (wellspan.org)
- An intravenous (IV) infusion of a substance made from human blood plasma (immunoglobulin) may be given. (wellspan.org)
- Antithymocyte Globulin (ATG) is a concentrated anti-human T-lymphocyte immunoglobulin preparation derived from rabbits after immunization with a T-lympoblast cell line. (drugbank.ca)
- however, other immunoglobulins are distributed into human milk. (drugbank.ca)
- A wide range of human and animal immunoglobulins (Igs) for use in immunological and biochemical applications have been isolated from normal or myeloma sources. (sigmaaldrich.com)
Antigen specific1
- Immunoglobulin (gammaglobulin) replacement is expensive and does not improve outcomes unless there is impairment of antigen-specific IgG antibody responses to vaccine immunizations or natural infections. (choosingwisely.org)
Blood14
- Immunoglobulin G (IgG) holds the highest share (44%) in the global blood plasma market, with a revenue of $9.24 billion. (frost.com)
- An allergen-specific immunoglobulin E (IgE) blood test is done to check whether a person is allergic to a particular substance. (kidshealth.org)
- Immunoglobulin can be collected from the plasma of donated blood. (oncolink.org)
- The main immunoglobulin of blood, lymph, and tissue fluid is immunoglobulin G ( IgG ). (encyclopedia.com)
- Immunoglobulin E ( IgE ) also normally has very low concentrations in blood and connective tissues, but it plays a crucial role in allergic reactions. (encyclopedia.com)
- For adults, elevated levels of immunoglobulin E or IgE are above 423 international units per milliliter of blood, according to WebMD. (reference.com)
- And even though immunoglobulins are obtained from blood, they are purified so that they can't pass on diseases to the person who receives them. (wellspan.org)
- Immunoglobulin is sometimes used to treat immune thrombocytopenic purpura (ITP), an immune disorder in which the body attacks the cells responsible for blood clotting (platelets), resulting in bleeding. (wellspan.org)
- As one of the 5 immunoglobulins found in the blood ,it is the first or primary immunoglobulin produced following exposure to an antigen. (healthtestingcenters.com)
- Egg yolk immunoglobulin (IgY) can successfully compete with immunoglobulin (IgG) produced in the blood of mammals. (scirp.org)
- Zoster Immunoglobulin-VF is prepared from blood obtained from voluntary donors. (nps.org.au)
- What is an immunoglobulins blood test? (medlineplus.gov)
- Why do I need an immunoglobulins blood test? (medlineplus.gov)
- You don't need any special preparations for an immunoglobulins blood test. (medlineplus.gov)
Secretions4
- one of the most common immunoglobulins, it is mainly present in body secretions and is the chief antibody in the mucous membranes of the gastrointestinal and respiratory tract and in saliva and tears. (labtestsonline.org)
- Immunoglobulin A ( IgA ) is found in saliva, tears, breast milk, and mucous secretions, where its role is to neutralize viruses and bacteria as they enter the body. (encyclopedia.com)
- sIgA is the main immunoglobulin found in mucous secretions , including tears , saliva , sweat , colostrum and secretions from the genitourinary tract , gastrointestinal tract , prostate and respiratory epithelium . (wikipedia.org)
- An investigation of the distribution of immunoglobulins in the external secretions of the hamster revealed the predominance of γA. (jimmunol.org)
FLCs1
- The present study demonstrated that during the process of metabolism of immunoglobulin FLCs, ROS activated the STAT1 pathway in proximal tubule epithelium. (jci.org)
Antibody responses1
- Some patients are capable of normal antibody responses of other immunoglobulin classes following specific immunization, whereas others respond poorly. (medscape.com)
Measles2
- These conditions include primary immunodeficiency , immune thrombocytopenic purpura , chronic inflammatory demyelinating polyneuropathy , Kawasaki disease , certain cases of HIV/AIDS and measles , Guillain-Barré syndrome , and certain other infections when a more specific immunoglobulin is not available. (wikipedia.org)
- You may be given an immunoglobulin if you are exposed to certain infectious diseases, such as hepatitis A , rubella , or measles. (wellspan.org)
Diseases3
- The Chinese company added that the bovine immunoglobulin G (IgG) kits helps to prevent and treat blue ear disease, respiratory pneumonia, pseudorabies, swine fever and foot and mouth disease, which are common diseases affecting pig in the farming industry. (thefreedictionary.com)
- IV immunoglobulin has been used safely for more than 20 years to treat other diseases but is thought to have an indirect effect on Alzheimer's disease by targeting beta-amyloid," Dr. Fillit said. (medpagetoday.com)
- And if I remember correctly these diseases occur with low immunoglobulin counts so the immunoglobulin being administered via IV may be to increase the levels as opposed to replenish the levels. (wisegeek.com)
Efficacy1
- The aim of this study is to study the efficacy of intravenous immunoglobulins for inducing remission in patients relapsing of systemic vasculitides. (clinicaltrials.gov)
Secretory component1
- Schematic of immunoglobulin A invasion showing of-privacy-hain (blue), L-chain (red), J-chain (magenta) and secretory component (yellow). (wikipedia.org)