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Immunoglobulins, IntravenousImmunization, PassiveEncyclopedias as TopicReceptors, IgGImmunoglobulinsImmunoglobulin GActinobacillus suisMice, HairlessImmunoglobulin AImmunoglobulin MPemphigoid, Benign Mucous MembraneSalivaImmunoglobulin EAllergensHypersensitivitySkin TestsHypersensitivity, ImmediateDesensitization, ImmunologicAsthmaEncephalomalaciaIgA DeficiencyDysgammaglobulinemiaAgammaglobulinemiaIgG DeficiencyImmunologic Deficiency SyndromesDictionaries, MedicalMeaslesMeasles virusMeasles VaccineDictionaries as TopicCrowdsourcingTerminology as TopicRho(D) Immune GlobulinElectronic MailRh IsoimmunizationErythroblastosis, FetalRh-Hr Blood-Group SystemFetomaternal TransfusionAbortion, ThreatenedCommon Variable ImmunodeficiencyImmunoglobulin Heavy ChainsReceptors, Polymeric ImmunoglobulinSecretory ComponentImmunoglobulin A, SecretoryEpithelial CellsPlasma CellsGenes, ImmunoglobulinDrug LabelingDrug RepositioningProduct LabelingUnited States Food and Drug AdministrationPrescription DrugsSearch Engine
Immunoglobulins, Intravenous: Immunoglobulin preparations used in intravenous infusion, containing primarily IMMUNOGLOBULIN G. They are used to treat a variety of diseases associated with decreased or abnormal immunoglobulin levels including pediatric AIDS; primary HYPERGAMMAGLOBULINEMIA; SCID; CYTOMEGALOVIRUS infections in transplant recipients, LYMPHOCYTIC LEUKEMIA, CHRONIC; Kawasaki syndrome, infection in neonates, and IDIOPATHIC THROMBOCYTOPENIC PURPURA.Immunization, Passive: Transfer of immunity from immunized to non-immune host by administration of serum antibodies, or transplantation of lymphocytes (ADOPTIVE TRANSFER).Encyclopedias as Topic: Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)Receptors, IgG: Specific molecular sites on the surface of various cells, including B-lymphocytes and macrophages, that combine with IMMUNOGLOBULIN Gs. Three subclasses exist: Fc gamma RI (the CD64 antigen, a low affinity receptor), Fc gamma RII (the CD32 antigen, a high affinity receptor), and Fc gamma RIII (the CD16 antigen, a low affinity receptor).Immunoglobulins: Multi-subunit proteins which function in IMMUNITY. They are produced by B LYMPHOCYTES from the IMMUNOGLOBULIN GENES. They are comprised of two heavy (IMMUNOGLOBULIN HEAVY CHAINS) and two light chains (IMMUNOGLOBULIN LIGHT CHAINS) with additional ancillary polypeptide chains depending on their isoforms. The variety of isoforms include monomeric or polymeric forms, and transmembrane forms (B-CELL ANTIGEN RECEPTORS) or secreted forms (ANTIBODIES). They are divided by the amino acid sequence of their heavy chains into five classes (IMMUNOGLOBULIN A; IMMUNOGLOBULIN D; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M) and various subclasses.Immunoglobulin G: The major immunoglobulin isotype class in normal human serum. There are several isotype subclasses of IgG, for example, IgG1, IgG2A, and IgG2B.Actinobacillus suis: A species of gram-negative bacteria in the genus ACTINOBACILLUS. It is mainly a pathogen of PIGS, but also can infect HORSES.Mice, Hairless: Mutant strains of mice that produce little or no hair.Immunoglobulin A: Represents 15-20% of the human serum immunoglobulins, mostly as the 4-chain polymer in humans or dimer in other mammals. Secretory IgA (IMMUNOGLOBULIN A, SECRETORY) is the main immunoglobulin in secretions.Immunoglobulin M: A class of immunoglobulin bearing mu chains (IMMUNOGLOBULIN MU-CHAINS). IgM can fix COMPLEMENT. The name comes from its high molecular weight and originally being called a macroglobulin.Pemphigoid, Benign Mucous Membrane: A chronic blistering disease with predilection for mucous membranes and less frequently the skin, and with a tendency to scarring. It is sometimes called ocular pemphigoid because of conjunctival mucous membrane involvement.Saliva: The clear, viscous fluid secreted by the SALIVARY GLANDS and mucous glands of the mouth. It contains MUCINS, water, organic salts, and ptylin.Immunoglobulin E: An immunoglobulin associated with MAST CELLS. Overexpression has been associated with allergic hypersensitivity (HYPERSENSITIVITY, IMMEDIATE).Allergens: Antigen-type substances that produce immediate hypersensitivity (HYPERSENSITIVITY, IMMEDIATE).Hypersensitivity: Altered reactivity to an antigen, which can result in pathologic reactions upon subsequent exposure to that particular antigen.Skin Tests: Epicutaneous or intradermal application of a sensitizer for demonstration of either delayed or immediate hypersensitivity. Used in diagnosis of hypersensitivity or as a test for cellular immunity.Hypersensitivity, Immediate: Hypersensitivity reactions which occur within minutes of exposure to challenging antigen due to the release of histamine which follows the antigen-antibody reaction and causes smooth muscle contraction and increased vascular permeability.Desensitization, Immunologic: Immunosuppression by the administration of increasing doses of antigen. Though the exact mechanism is not clear, the therapy results in an increase in serum levels of allergen-specific IMMUNOGLOBULIN G, suppression of specific IgE, and an increase in suppressor T-cell activity.Asthma: A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).Encephalomalacia: Softening or loss of brain tissue following CEREBRAL INFARCTION; cerebral ischemia (see BRAIN ISCHEMIA), infection, CRANIOCEREBRAL TRAUMA, or other injury. The term is often used during gross pathologic inspection to describe blurred cortical margins and decreased consistency of brain tissue following infarction. Multicystic encephalomalacia refers to the formation of multiple cystic cavities of various sizes in the cerebral cortex of neonates and infants following injury, most notably perinatal hypoxia-ischemic events. (From Davis et al., Textbook of Neuropathology, 2nd ed, p665; J Neuropathol Exp Neurol, 1995 Mar;54(2):268-75)IgA Deficiency: A dysgammaglobulinemia characterized by a deficiency of IMMUNOGLOBULIN A.Dysgammaglobulinemia: An immunologic deficiency state characterized by selective deficiencies of one or more, but not all, classes of immunoglobulins.Agammaglobulinemia: An immunologic deficiency state characterized by an extremely low level of generally all classes of gamma-globulin in the blood.IgG Deficiency: A dysgammaglobulinemia characterized by a deficiency of IMMUNOGLOBULIN G.Immunologic Deficiency Syndromes: Syndromes in which there is a deficiency or defect in the mechanisms of immunity, either cellular or humoral.Dictionaries, MedicalMeasles: A highly contagious infectious disease caused by MORBILLIVIRUS, common among children but also seen in the nonimmune of any age, in which the virus enters the respiratory tract via droplet nuclei and multiplies in the epithelial cells, spreading throughout the MONONUCLEAR PHAGOCYTE SYSTEM.Measles virus: The type species of MORBILLIVIRUS and the cause of the highly infectious human disease MEASLES, which affects mostly children.Measles Vaccine: A live attenuated virus vaccine of chick embryo origin, used for routine immunization of children and for immunization of adolescents and adults who have not had measles or been immunized with live measles vaccine and have no serum antibodies against measles. Children are usually immunized with measles-mumps-rubella combination vaccine. (From Dorland, 28th ed)Dictionaries as Topic: Lists of words, usually in alphabetical order, giving information about form, pronunciation, etymology, grammar, and meaning.Crowdsourcing: Social media model for enabling public involvement and recruitment in participation. Use of social media to collect feedback and recruit volunteer subjects.Terminology as Topic: The terms, expressions, designations, or symbols used in a particular science, discipline, or specialized subject area.Rho(D) Immune Globulin: Immunizing agent containing IMMUNOGLOBULIN G anti-Rho(D) used for preventing Rh immunization in Rh-negative individuals exposed to Rh-positive red blood cells.Electronic Mail: Messages between computer users via COMPUTER COMMUNICATION NETWORKS. This feature duplicates most of the features of paper mail, such as forwarding, multiple copies, and attachments of images and other file types, but with a speed advantage. The term also refers to an individual message sent in this way.Rh Isoimmunization: The process by which fetal Rh+ erythrocytes enter the circulation of an Rh- mother, causing her to produce IMMUNOGLOBULIN G antibodies, which can cross the placenta and destroy the erythrocytes of Rh+ fetuses. Rh isoimmunization can also be caused by BLOOD TRANSFUSION with mismatched blood.Erythroblastosis, Fetal: A condition characterized by the abnormal presence of ERYTHROBLASTS in the circulation of the FETUS or NEWBORNS. It is a disorder due to BLOOD GROUP INCOMPATIBILITY, such as the maternal alloimmunization by fetal antigen RH FACTORS leading to HEMOLYSIS of ERYTHROCYTES, hemolytic anemia (ANEMIA, HEMOLYTIC), general edema (HYDROPS FETALIS), and SEVERE JAUNDICE IN NEWBORN.Rh-Hr Blood-Group System: Erythrocyte isoantigens of the Rh (Rhesus) blood group system, the most complex of all human blood groups. The major antigen Rh or D is the most common cause of erythroblastosis fetalis.Fetomaternal Transfusion: Transplacental passage of fetal blood into the circulation of the maternal organism. (Dorland, 27th ed)Abortion, Threatened: UTERINE BLEEDING from a GESTATION of less than 20 weeks without any CERVICAL DILATATION. It is characterized by vaginal bleeding, lower back discomfort, or midline pelvic cramping and a risk factor for MISCARRIAGE.Common Variable Immunodeficiency: Heterogeneous group of immunodeficiency syndromes characterized by hypogammaglobulinemia of most isotypes, variable B-cell defects, and the presence of recurrent bacterial infections.Immunoglobulin Heavy Chains: The largest of polypeptide chains comprising immunoglobulins. They contain 450 to 600 amino acid residues per chain, and have molecular weights of 51-72 kDa.Receptors, Polymeric Immunoglobulin: Specialized Fc receptors (RECEPTORS, FC) for polymeric immunoglobulins, which mediate transcytosis of polymeric IMMUNOGLOBULIN A and IMMUNOGLOBULIN M into external secretions. They are found on the surfaces of epithelial cells and hepatocytes. After binding to IMMUNOGLOBULIN A, the receptor-ligand complex undergoes endocytosis, transport by vesicle, and secretion into the lumen by exocytosis. Before release, the part of the receptor (SECRETORY COMPONENT) that is bound to IMMUNOGLOBULIN A is proteolytically cleaved from its transmembrane tail. (From Rosen et al., The Dictionary of Immunology, 1989)Secretory Component: The extracellular moiety of the POLYMERIC IMMUNOGLOBULIN RECEPTOR found alone or complexed with IGA or IGM, in a variety of external secretions (tears, bile, colostrum.) Secretory component is derived by proteolytic cleavage of the receptor during transcytosis. When immunoglobulins IgA and IgM are bound to the receptor, during their transcytosis secretory component becomes covalently attached to them generating SECRETORY IMMUNOGLOBULIN A or secretory IMMUNOGLOBULIN M.Immunoglobulin A, Secretory: The principle immunoglobulin in exocrine secretions such as milk, respiratory and intestinal mucin, saliva and tears. The complete molecule (around 400 kD) is composed of two four-chain units of IMMUNOGLOBULIN A, one SECRETORY COMPONENT and one J chain (IMMUNOGLOBULIN J-CHAINS).Epithelial Cells: Cells that line the inner and outer surfaces of the body by forming cellular layers (EPITHELIUM) or masses. Epithelial cells lining the SKIN; the MOUTH; the NOSE; and the ANAL CANAL derive from ectoderm; those lining the RESPIRATORY SYSTEM and the DIGESTIVE SYSTEM derive from endoderm; others (CARDIOVASCULAR SYSTEM and LYMPHATIC SYSTEM) derive from mesoderm. Epithelial cells can be classified mainly by cell shape and function into squamous, glandular and transitional epithelial cells.Plasma Cells: Specialized forms of antibody-producing B-LYMPHOCYTES. They synthesize and secrete immunoglobulin. They are found only in lymphoid organs and at sites of immune responses and normally do not circulate in the blood or lymph. (Rosen et al., Dictionary of Immunology, 1989, p169 & Abbas et al., Cellular and Molecular Immunology, 2d ed, p20)Genes, Immunoglobulin: Genes encoding the different subunits of the IMMUNOGLOBULINS, for example the IMMUNOGLOBULIN LIGHT CHAIN GENES and the IMMUNOGLOBULIN HEAVY CHAIN GENES. The heavy and light immunoglobulin genes are present as gene segments in the germline cells. The completed genes are created when the segments are shuffled and assembled (B-LYMPHOCYTE GENE REARRANGEMENT) during B-LYMPHOCYTE maturation. The gene segments of the human light and heavy chain germline genes are symbolized V (variable), J (joining) and C (constant). The heavy chain germline genes have an additional segment D (diversity).Drug Labeling: Use of written, printed, or graphic materials upon or accompanying a drug container or wrapper. It includes contents, indications, effects, dosages, routes, methods, frequency and duration of administration, warnings, hazards, contraindications, side effects, precautions, and other relevant information.Drug Repositioning: The deliberate and methodical practice of finding new applications for existing drugs.Product Labeling: Use of written, printed, or graphic materials upon or accompanying a product or its container or wrapper. It includes purpose, effect, description, directions, hazards, warnings, and other relevant information.United States Food and Drug Administration: An agency of the PUBLIC HEALTH SERVICE concerned with the overall planning, promoting, and administering of programs pertaining to maintaining standards of quality of foods, drugs, therapeutic devices, etc.Prescription Drugs: Drugs that cannot be sold legally without a prescription.Search Engine: Software used to locate data or information stored in machine-readable form locally or at a distance such as an INTERNET site.

The role of colorstrum on the occurrence of immunoglobulin G subclasses and antibody production in neonatal goats. (1/23942)

Quantitative determinations of IgG1 and IgG2, in one group of colostrum-fed and one group of colostrum-deprived neonatal goats revealed that the occurrence of the IgG1 subclass preceeded that of the IgG2 in both cases. In the colostrum-fed animals the IgG2 appeared, on an average, in the fourth week of life whereas in the colostrum-deprived animals the IgG2 was detected as early as three weeks after birth. At the age of twelve weeks the mean concentrations for IgG, and IgG2 were higher in the animals deprived of colostrum. The immune response to human gamma globulin was studied in colostrum-fed and colostrum-deprived neonatal goats which were immunized at birth and again after four and eight weeks. Following the first two antigen administrations a significantly higher response was obtained in the colostrum-fed neonates. However, the third injection determined a similar response in both groups. A marked suppressive effect on the immune response was observed in colostrum-fed neonatal goats when specific antibodies were present in the colostrum after preimmunization of the mothers with human gamma globulin.  (+info)

Features of the immune response to DNA in mice. I. Genetic control. (2/23942)

The genetic control of the immune response to DNA was studied in various strains of mice F1 hybrids and corresponding back-crosses immunized with single stranded DNA complexed to methylated bovine serum albumin. Anti-DNA antibody response was measured by radioimmuno-logical technique. High responder, low responder, and intermediate responder strains were found and the ability to respond to DNA was characterized as a dominant genetic trait which is not linked to the major locus of histocompatibility. Studies in back-crosses suggested that this immune response is under multigenic control. High responder mice produce both anti-double stranded DNA and anti-single stranded DNA 7S and 19S antibodies, while low responder mice produce mainly anti-single stranded DNA 19S antibodies.  (+info)

VEGF is required for growth and survival in neonatal mice. (3/23942)

We employed two independent approaches to inactivate the angiogenic protein VEGF in newborn mice: inducible, Cre-loxP- mediated gene targeting, or administration of mFlt(1-3)-IgG, a soluble VEGF receptor chimeric protein. Partial inhibition of VEGF achieved by inducible gene targeting resulted in increased mortality, stunted body growth and impaired organ development, most notably of the liver. Administration of mFlt(1-3)-IgG, which achieves a higher degree of VEGF inhibition, resulted in nearly complete growth arrest and lethality. Ultrastructural analysis documented alterations in endothelial and other cell types. Histological and biochemical changes consistent with liver and renal failure were observed. Endothelial cells isolated from the liver of mFlt(1-3)-IgG-treated neonates demonstrated an increased apoptotic index, indicating that VEGF is required not only for proliferation but also for survival of endothelial cells. However, such treatment resulted in less significant alterations as the animal matured, and the dependence on VEGF was eventually lost some time after the fourth postnatal week. Administration of mFlt(1-3)-IgG to juvenile mice failed to induce apoptosis in liver endothelial cells. Thus, VEGF is essential for growth and survival in early postnatal life. However, in the fully developed animal, VEGF is likely to be involved primarily in active angiogenesis processes such as corpus luteum development.  (+info)

Interaction of inflammatory cells and oral microorganisms. III. Modulation of rabbit polymorphonuclear leukocyte hydrolase release response to Actinomyces viscosus and Streptococcus mutans by immunoglobulins and complement. (4/23942)

In the absence of antiserum, rabbit polymorphonuclear leukocytes (PMNs) released lysosomal enzymes in response to Actinomyces viscosus (19246) but not to Streptococcus mutans (6715). Antibodies had a marked modulating influence on these reactions. PMN hydrolase release was significantly enhanced to both organisms when specific rabbit antiserum and isolated immunoglobulin G (IgG) were included in the incubations. Immune complex F(ab')2 fragments of IgG directed against S. mutans agglutinated bacteria. Immune complexes consisting of S. mutans and F(ab')2 fragments of IgG directed against this organism were not effective as bacteria-IgG complexes in stimulating PMN release. The intensity of the release response to bacteria-IgG complexes was also diminished when PMNs were preincubated with isolated Fc fragments derived from IgG. Fresh serum as a source of complement components had no demonstrable effect on PMN release either alone or in conjuction with antiserum in these experiments. These data may be relevant to the mechanisms and consequences of the interaction of PMNs and plaque bacteria in the pathogenesis of periodontal disease.  (+info)

Prevention of collagen-induced arthritis by gene delivery of soluble p75 tumour necrosis factor receptor. (5/23942)

Collagen type II-induced arthritis (CIA) in DBA/1 mice can be passively transferred to SCID mice with spleen B- and T-lymphocytes. In the present study, we show that infection ex vivo of splenocytes from arthritic DBA/1 mice with a retroviral vector, containing cDNA for the soluble form of human p75 receptor of tumour necrosis factor (TNF-R) before transfer, prevents the development of arthritis, bone erosion and joint inflammation in the SCID recipients. Assessment of IgG subclass levels and studies of synovial histology suggest that down-regulating the effector functions of T helper-type 1 (Th1) cells may, at least in part, explain the inhibition of arthritis in the SCID recipients. In contrast, the transfer of splenocytes infected with mouse TNF-alpha gene construct resulted in exacerbated arthritis and enhancement of IgG2a antibody levels. Intriguingly, infection of splenocytes from arthritic DBA/1 mice with a construct for mouse IL-10 had no modulating effect on the transfer of arthritis. The data suggest that manipulation of the immune system with cytokines, or cytokine inhibitors using gene transfer protocols can be an effective approach to ameliorate arthritis.  (+info)

Variable domain-linked oligosaccharides of a human monoclonal IgG: structure and influence on antigen binding. (6/23942)

The variable-domain-attached oligosaccharide side chains of a human IgG produced by a human-human-mouse heterohybridoma were analysed. In addition to the conserved N-glycosylation site at Asn-297, an N-glycosylation consensus sequence (Asn-Asn-Ser) is located at position 75 in the variable region of its heavy chain. The antibody was cleaved into its antigen-binding (Fab) and crystallizing fragments. The oligosaccharides of the Fab fragment were released by digestion with various endo- and exoglycosidases and analysed by anion-exchange chromatography and fluorophore-assisted carbohydrate electrophoresis. The predominant components were disialyl- bi-antennary and tetra-sialyl tetra-antennary complex carbohydrates. Of note is the presence in this human IgG of oligosaccharides containing N-glycolylneuraminic acid and N-acetylneuraminic acid in the ratio of 94:6. Furthermore, we determined N-acetylgalactosamine in the Fab fragment of this antibody, suggesting the presence of O-linked carbohydrates. A three-dimensional structure of the glycosylated variable (Fv) fragment was suggested using computer-assisted modelling. In addition, the influence of the Fv-associated oligosaccharides of the CBGA1 antibody on antigen binding was tested in several ELISA systems. Deglycosylation resulted in a decreased antigen-binding activity.  (+info)

Zonula occludens toxin is a powerful mucosal adjuvant for intranasally delivered antigens. (7/23942)

Zonula occludens toxin (Zot) is produced by toxigenic strains of Vibrio cholerae and has the ability to reversibly alter intestinal epithelial tight junctions, allowing the passage of macromolecules through the mucosal barrier. In the present study, we investigated whether Zot could be exploited to deliver soluble antigens through the nasal mucosa for the induction of antigen-specific systemic and mucosal immune responses. Intranasal immunization of mice with ovalbumin (Ova) and recombinant Zot, either fused to the maltose-binding protein (MBP-Zot) or with a hexahistidine tag (His-Zot), induced anti-Ova serum immunoglobulin G (IgG) titers that were approximately 40-fold higher than those induced by immunization with antigen alone. Interestingly, Zot also stimulated high anti-Ova IgA titers in serum, as well as in vaginal and intestinal secretions. A comparison with Escherichia coli heat-labile enterotoxin (LT) revealed that the adjuvant activity of Zot was only sevenfold lower than that of LT. Moreover, Zot and LT induced similar patterns of Ova-specific IgG subclasses. The subtypes IgG1, IgG2a, and IgG2b were all stimulated, with a predominance of IgG1 and IgG2b. In conclusion, our results highlight Zot as a novel potent mucosal adjuvant of microbial origin.  (+info)

The levels and bactericidal capacity of antibodies directed against the UspA1 and UspA2 outer membrane proteins of Moraxella (Branhamella) catarrhalis in adults and children. (8/23942)

The UspA1 and UspA2 proteins from Moraxella catarrhalis share antigenic epitopes and are promising vaccine candidates. In this study, the levels and bactericidal activities of antibodies in sera from healthy adults and children toward UspA1 and UspA2 from the O35E strain were measured. Human sera contained antibodies to both proteins, and the levels of immunoglobulin G (IgG) antibodies were age dependent. Adult sera had significantly higher titers of IgG than child sera (P < 0.01). The IgG3 titers to the UspA proteins were higher than the IgG1 titers in the adults' sera, while the IgG1 titers were higher than the IgG3 titers in the children's sera (P < 0.05). The IgG antibodies in the sera from 2-month-old children appeared to be maternally derived, since the mean titer was significantly higher than that in sera from 6- to 7-month-old children (P < 0.05). Serum IgA antibodies to both UspA1 and UspA2 were low during the first 7 months of age but thereafter gradually increased along with the IgG titers. Analysis of sera absorbed with UspA1 or UspA2 showed that the antibodies to UspA1 and UspA2 were cross-reactive with each other and associated with serum bactericidal activity. Examination of affinity-purified human antibodies confirmed that naturally acquired antibodies to UspA1 and UspA2 were bactericidal and cross-reactive. These results support using UspA1 and UspA2 in a vaccine to prevent M. catarrhalis infections.  (+info)

Specific IgG Subclass Antibody Levels and Phagocytosis of Serotype 14 Pneumococcus Following Immunization<...Specific IgG Subclass Antibody Levels and Phagocytosis of Serotype 14 Pneumococcus Following Immunization<...
TY - JOUR. T1 - Specific IgG Subclass Antibody Levels and Phagocytosis of Serotype 14 Pneumococcus Following Immunization. AU - KANIUK, A. St C.. AU - LORTAN, J. E.. AU - MONTEIL, M. A.. PY - 1992/12. Y1 - 1992/12. N2 - Complement and specific antibody directed against capsular polysaccharide are necessary for efficient phagocytosis of pneumococci. In normal adults, specific antibody to pneumococci is predominantly of the IgG2 subclass. However, the role of IgG2 in bacterial clearance is debatable. We therefore decided to investigate the relationship between specific IgG subclass antibody levels and phagocytosis of serotype 14 pneumococcus, before and after immunization with a pneumococcal capsular polysaccharide vaccine. Specific IgG subclass antibody was measured by an ELISA technique and the effect of serum on phagocytosis of radiolabelled pneumococci by normal polymorphs was determined. We found that in the presence of complement, phagocytosis correlated significantly with both specific IgGl ...
Pneumococcal vaccination responses in adults with subnormal IgG subclass concentrations | BMC Immunology | Full TextPneumococcal vaccination responses in adults with subnormal IgG subclass concentrations | BMC Immunology | Full Text
We sought to compare Pneumovax®23 responses in adults with subnormal IgG subclass concentrations. We studied adults with normal total IgG, frequent/severe respiratory infection, and subnormal IgG1, IgG3, or IgG1 + IgG3 before and after Pneumovax®23. We defined response as serotype-specific IgG | 1.3 μg/mL and aggregate response as IgG | 1.3 μg/mL for ≥70% of all serotypes tested. We compared patients with and without serotype-specific responses and performed logistic regression on aggregate responses using: age; male sex; body mass index; autoimmune condition(s); atopy; other allergies; subnormal IgGSc immunophenotypes; IgA; and IgM. There were 59 patients (mean age 44 ± 13 (SD) years; 83.1% women). Median days between pre- and post-Pneumovax®23 testing was 33 (range 19-158). The median post-vaccination summated concentration of serotype-specific IgG was higher in patients with subnormal IgG1 than subnormal IgG3 (responders and non-responders). All subnormal IgG1 + IgG3 non-responders responded
A cohort study of the association between serum immunoglobulin G concentration and preweaning health, growth, and survival in...A cohort study of the association between serum immunoglobulin G concentration and preweaning health, growth, and survival in...
TY - JOUR. T1 - A cohort study of the association between serum immunoglobulin G concentration and preweaning health, growth, and survival in Holstein calves. AU - Pithua, P.. AU - Aly, Sharif S. PY - 2013. Y1 - 2013. N2 - The association between serum IgG concentration and preweaning health performance in Holstein calves were evaluated in a prospective cohort study design framework. Post colostral blood samples were collected from 561 calves and serum IgG concentrations were quantitated using a single radial immunodiffusion assay. Preweaning treatments for diarrhea, pneumonia, omphalitis and frequency of antibiotic therapy plus calf death events were recorded until calves were weaned at approximately 60 d of age. Logistic regression modeling was used to evaluate the association between failure of passive transfer of immunity (FPT, serum IgG , 10g/L) and risk of diarrhea, pneumonia, omphalitis, frequency of antibiotic therapy and death. Calves with FPT were twice as likely to suffer from scours ...
Selective increases in antibody isotypes and immunoglobulin G subclass responses to secreted antigens in tuberculosis patients...Selective increases in antibody isotypes and immunoglobulin G subclass responses to secreted antigens in tuberculosis patients...
Mycobacterium tuberculosis-specific antibodies (immunoglobulin M [IgM], IgE, IgG, and IgG subclasses) were determined in 164 tuberculosis patients (pulmonary involvement, n = 135; lymph node involvement, n = 29), 59 healthy household contacts (HC), and 51 healthy endemic donors (EC) by a quantitative enzyme-linked immunosorbent assay for reactivity with culture filtrate. Among the isotypes, significant differences between tuberculosis patient groups with either pulmonary or lymph node involvement and healthy control groups (HC and EC) were detected only for IgG (P , 0.001) and IgG1 (P , 0.001) antibodies. Pulmonary patients also showed a significant difference with IgM (P , 0.01) and IgE (P , 0.05) antibodies. HC showed elevation of only IgM antibodies compared with EC, indicating that IgM antibodies may be an indicator of recent infection with M. tuberculosis. These results suggest that the switching of IgM antibody response to IgG1 is a critical event in disease progression. Polyclonal IgG1, ...
cusabio human ganglioside q1b gq1b antibody igg elisa kit - Diagnostic test kitcusabio human ganglioside q1b gq1b antibody igg elisa kit - Diagnostic test kit
Dog Immunoglobulin G (IgG) ELISA kit CSB EQ028049DO Cusabio. Human Immunoglobulin G(IgG)ELISA Kit CSB E07979h Cusabio. Pig Immunoglobulin G(IgG) ELISA Kit CSB E06804p Cusabio. Mouse Immunoglobulin G,IgG ELISA Kit CSB E07980m Cusabio. Bovine Immunoglobulin G,IgG ELISA Kit CSB E12015B Cusabio ...
PM.3.3.2.0007.15 Normal human immunoglobulin | Pharmacopoeia.ruPM.3.3.2.0007.15 Normal human immunoglobulin | Pharmacopoeia.ru
PM.3.3.2.0007.15 Normal human immunoglobulin Ministry of Health of the Russian Federation Pharmacopoeia Monograph Normal human immunoglobulin PM.3.3.2.0007.15
IgG - Immunoglobulin G Class Antibody | Bio-RadIgG - Immunoglobulin G Class Antibody | Bio-Rad
Human IgG (immunoglobulin G) is expressed on the surface of mature B cells. It is the most prevalent Ig in serum and the major Ig in extravascular spaces. Find out more and explore our range of IgG antibodies
Immunoglobulin G (IgG), Human Plasma | LeeBio.comImmunoglobulin G (IgG), Human Plasma | LeeBio.com
Buy high purity Immunoglobulin G (IgG) from human plasma for diagnostic manufacturing, control, calibrator and research uses - Inquire for details!
human immunoglobulin elisa kithuman immunoglobulin elisa kit
Human IgG4 human immunoglobulin elisa kit Immunoglobulin G4 ELISA Kit from ELISA Genie is a pre-coated immunoassay with a sensitivity of 4.688 ng human immunoglobulin elisa kitml and a range of 7.813-500ng human immunoglobulin elisa kitml and has been designed to measure Human IgG4 human immunoglobulin elisa kit Immunoglobulin G4 ELISA Kit in serum, plasma & cell culture supernatant samples. The Human IgG4 human immunoglobulin elisa kit Immunoglobulin G4 ELISA Kit accurately measures natural Human IgG4 human immunoglobulin elisa kit Immunoglobulin ...
Rabbit Anti-Human IgG (H+L) Absorbed against mouse immunoglobulinsRabbit Anti-Human IgG (H+L) Absorbed against mouse immunoglobulins
... , Rabbit Anti-Human IgG(H+L), Mouse ads-UNLB; N/A; N/A Rabbit Anti-Human IgG (H+L) Absorbed against mouse immunoglobulins
A Case of Brutons Disease with Normal Immunoglobulin G LevelA Case of Bruton's Disease with Normal Immunoglobulin G Level
X-linked agamaglobulinemia (XLA) or Brutons disease is a genetic disease resulting from a mutation in the Brutons tyrosine kinase (Btk) gene. This mutation leads to B cell arrest during differentiation (1). This disease was first described by Ogden Bruton in 1952 (2). Approximately 85% of the affected subjects are male (3). This disorder is inherited as an X-linked recessive trait. Carrier females have no symptoms but have a 50% chance for transmission of the disorder to each of their sons. It is now possible to determine if the fetus of a carrier mother has XLA (4). The prevalence of the disease ranges from 1 in 10,000 to 1 in 50,000 (1). Half of the affected individuals are diagnosed during the first year of life and more than 90% of them are diagnosed up to fifth year (3). Diagnosis of the disease is suggested by lymphoid hypoplasia (minimal or no tonsillar tissue and no palpable lymph node) and total immunoglobulins level less than 100 mg/dl. Isohemagglutinins and antibodies to antigens given
Frontiers | Fc-Glycosylation in Human IgG1 and IgG3 Is Similar for Both Total and Anti-Red-Blood Cell Anti-K Antibodies |...Frontiers | Fc-Glycosylation in Human IgG1 and IgG3 Is Similar for Both Total and Anti-Red-Blood Cell Anti-K Antibodies |...
After albumin, immunoglobulin G (IgG) are the most abundant proteins in human serum, with IgG1 and IgG3 being the most abundant subclasses directed against protein antigens. The quality of the IgG-Fc-glycosylation has important functional consequences, which have been found to be skewed towards low fucosylation in some antigen-specific immune responses. This increases the affinity to IgG1-Fc-receptor (FcγR)IIIa/b and thereby directly affects downstream effector functions and disease severity. To date, antigen-specific IgG-glycosylation have not been analyzed for IgG3. Here, we analyzed 30 pregnant women with anti-K alloantibodies from a prospective screening cohort and compared the type of Fc-tail glycosylation of total serum- and antigen-specific IgG1 and IgG3 using mass spectrometry. Total serum IgG1 and IgG3 Fc-glycoprofiles were highly similar. Fc glycosylation of antigen-specific IgG varied greatly between individuals, but correlated significantly with each other for IgG1 and IgG3, except for
Goat Anti-Human IgG F(c) secondary antibody (Peroxidase) - (PAB10704) - Products - AbnovaGoat Anti-Human IgG F(c) secondary antibody (Peroxidase) - (PAB10704) - Products - Abnova
Goat anti-human IgG recognizes human IgG F(c) fragment. This secondary antibody was purified using antigen affinity chromatography. The antibody is conjugated with Peroxidase. Human IgG F(c) fragment (PAB10704) - Products - Abnova
PM.3.3.2.0008.15 Normal human immunoglobulin for intravenous administration | Pharmacopoeia.ruPM.3.3.2.0008.15 Normal human immunoglobulin for intravenous administration | Pharmacopoeia.ru
PM.3.3.2.0008.15 Normal human immunoglobulin for intravenous administration Ministry of Health of the Russian Federation Pharmacopoeia Monograph Normal human
Goat anti-Human IgG Fc, F(ab)2 Fragment, Affinity purified, TRITC conj, secondary antibodyGoat anti-Human IgG Fc, F(ab)'2 Fragment, Affinity purified, TRITC conj, secondary antibody
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Hi Netters, I am working on the purification of monoclonal mouse antibody IgG2b for my thesis work. I am trying to use hollow fiber modules modified with either protein A or protein G. I am also planning to immobilize anti-mouse IgG, in the near future. So far I have been unsuccessful in getting high capacities with protein A or protein G modules. I would appreciate if anyone of you could highlight me on any special conditions/buffers that I might have to use for getting high capacities. Please reply to the following e-mail address: sjwaig01 at ulkyvm.louisville.edu Thanks in advance. Sincerely, Sabine ...
Goat anti-human IgG (H&L), F(ab)2 fragment, no reactivity to bovine/mouse/rabbit serum, ALP (alkaline phosphatase) conjugated...Goat anti-human IgG (H&L), F(ab)'2 fragment, no reactivity to bovine/mouse/rabbit serum, ALP (alkaline phosphatase) conjugated...
Goat anti-human IgG (H&L), F(ab)2 fragment, no reactivity to bovine/mouse/rabbit serum, ALP (alkaline phosphatase) conjugated secondary antibody , absorbed secondary antibody to human IgG F(ab)2 fragment, AS10 781
Goat anti-Human IgG (H+L) Secondary Antibody [Alkaline Phosphatase] (NBP1-74940): Novus BiologicalsGoat anti-Human IgG (H+L) Secondary Antibody [Alkaline Phosphatase] (NBP1-74940): Novus Biologicals
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Goat anti-Human IgG (H+L), Texas Red®Goat anti-Human IgG (H+L), Texas Red®
Goat anti-Human IgG (H+L) Secondary Antibody, Texas Red® conjugate from Invitrogen for Flow Cytometry applications. Supplied as 100 µg purified secondary antibody (1 mg/ml) in 0.02M potassium phosphate with 10mg/ml BSA, 0.15M NaCl and 0.01% sodium azide; pH 7.2.
Goat Anti-Human IgG (Fab)2 (AP) (ab87408) ReferencesGoat Anti-Human IgG (Fab')2 (AP) (ab87408) References
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Pure Goat Anti-Human IgG Gel, Specific Immobilized Antibodies, 2mL Kit - EY Laboratories, Inc.Pure Goat Anti-Human IgG Gel, Specific Immobilized Antibodies, 2mL Kit - EY Laboratories, Inc.
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Book Anti Phospholipid Antibody Igg with Thyrocare Laboratories in allahabad @ Rs. 660 | 1mgLabsBook Anti Phospholipid Antibody Igg with Thyrocare Laboratories in allahabad @ Rs. 660 | 1mgLabs
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3.3.2. Properties of Immunoglobulins3.3.2. Properties of Immunoglobulins
... General. All immunoglobulins appear to be glycoproteins but the carbohydrate content ranges from 2-3% for IgG to 12-14% for IgM, IgD and IgE. The physicochemical proper-ties of the immunoglobulins are summarized in Table 3.2. Each class possesses a characteristic type of heavy chain. Thus IgG possesses g chains; IgM, m chains; IgA, achains, IgD, dchains and IgE, echains. Variation in heavy chain structure within a class gives rise to immunoglobulin subclasses. For example the human IgG pool consists of four subclasses reflecting four distinct types of g heavy chain. The physicochemical properties of the immunoglobulins vary between the different classes. Note that IgA occurs in a dimeric form {sigA) in association with a protein chain termed the secretory piece. The diversity of structure of the different classes suggests that they perform different functions, in addition to their primary function of antigen binding. In spite of this diver-sity all ...
Data Sheet 1 Characterization of the C1q-Binding Ability and the IgG1-4 Subclass Profile of Preformed Anti-HLA Antibodies by...Data Sheet 1 Characterization of the C1q-Binding Ability and the IgG1-4 Subclass Profile of Preformed Anti-HLA Antibodies by...
Data_Sheet_1_Characterization of the C1q-Binding Ability and the IgG1-4 Subclass Profile of Preformed Anti-HLA Antibodies by Solid-Phase Assays.docx
IgG4 elisa kit | Human Immunoglobulin G4 (IgG4) ELISA Kit-NP 036224.1IgG4 elisa kit | Human Immunoglobulin G4 (IgG4) ELISA Kit-NP 036224.1
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Targeting antigens to CD180 rapidly induces antigen-specific IgG, affinity maturation, and immunological memory | JEMTargeting antigens to CD180 rapidly induces antigen-specific IgG, affinity maturation, and immunological memory | JEM
Collectively, our data indicate that targeting Ags to CD180 induces rapid activation of Ag-specific B cells, leading to significant IgG production within 7 d. Remarkably, a single injection of Ag-αCD180 without any additional adjuvant also led to the development of both Ab affinity maturation and immunological memory (Fig. 3). Furthermore, although severely impaired, Ag-specific IgG production and responses to secondary immunizations were retained in CD40 KO mice (Fig. 3 H), even though CD40 KO mice did not make Ag-specific IgG or develop memory Ab-producing cells in response to Ag in alum, as reported previously (Kawabe et al., 1994). The Ab responses induced required the Ags to be attached to anti-CD180 and could be induced to both haptens and protein Ags.. Why is this mode of immunization so effective in rapidly raising IgG Ab responses? Previous studies showed that i.p. inoculation of high doses of αCD180 could induce increases in plasma cells (500 µg) and polyclonal Ig production (250 ...
Elevated Igg Index / CSF - Multiple Sclerosis - MedHelpElevated Igg Index / CSF - Multiple Sclerosis - MedHelp
Does the IgG index fluctuate with MS? Would it be higher when you are having an attack or flair/many symptoms? Or is it like the csf o-bands that are a relatively permanent thing in ms? Reas...
Polyclonal Sheep IgG purification kitPolyclonal Sheep IgG purification kit
Sheep IgG Binding Buffer (Code : BBSPG) : The Sheep IgG Binding Buffer (Code : BBSPG) will be obtained by adding 1 volume of distilled water to 1 volume of Sheep IgG Loading Buffer (Code : LBSPG ...
Molecule of an immunoglobulin G1 antibody - Stock Image P270/0045 - Science Photo LibraryMolecule of an immunoglobulin G1 antibody - Stock Image P270/0045 - Science Photo Library
Antibody. Computer graphic of a molecule of immunoglobulin G1, a type of antibody protein that the immune system uses to fight infections. Like all proteins, it is comprised of amino acid groups. Immunoglobulin G is the most common antibody found in blood. They are produced by lymphocytes (a type of white blood cell) in response to the proteins (antigens) found on foreign cells such as bacteria and viruses. Each antibody recognises a specific antigen, either destroying or neutralising it. Immunoglobulin G can cross a mothers placenta, making it important in the immune response of a developing foetus. - Stock Image P270/0045
Goat Anti-Human IgA (alpha chain) secondary antibody - (PAB9280) - Products - AbnovaGoat Anti-Human IgA (alpha chain) secondary antibody - (PAB9280) - Products - Abnova
Goat anti-human IgG recognizes human IgA alpha heavy chain. This secondary antibody was purified using antigen affinity chromatography. Human IgA alpha heavy chain (PAB9280) - Products - Abnova
anti-Human IgG antibody, pre-adsorbed (TxRd) | GeneTexanti-Human IgG antibody, pre-adsorbed (TxRd) | GeneTex
Human IgG antibody, pre-adsorbed (TxRd) for ELISA, FACS, ICC/IF. Anti-Human IgG pAb (GTX27151) is tested in Human samples. 100% Ab-Assurance.
NPA544Ga01 | 免疫球蛋白G(IgG)天然蛋白 | Chicken (Gallus，鸡) USCN(武汉优尔生商贸有限公司)NPA544Ga01 | 免疫球蛋白G(IgG)天然蛋白 | Chicken (Gallus，鸡) USCN(武汉优尔生商贸有限公司)
NPA544Ga01, Native Immunoglobulin G (IgG), 免疫球蛋白G(IgG)天然蛋白, | 仅供体外研究使用，不用于临床诊断！请索取进口关税税单及报关单！
Rabbit IgG (H&L) Secondary Antibody Biotin Conjugated Pre-Adsorbed 611-106-122Rabbit IgG (H&L) Secondary Antibody Biotin Conjugated Pre-Adsorbed 611-106-122
Anti-Rabbit IgG (H&L) Biotin Antibody generated in goat detects reactivity to Rabbit IgG. Secreted as part of the adaptive immune response by plasma B cells, immunoglobulin G constitutes 75% of serum immunoglobulins. Immunoglobulin G binds to viruses, bacteria, as well as fungi and facilitates their destruction or neutralization via agglutination (and thereby immobilizing them), activation of the compliment cascade, and opsinization for phagocytosis. The whole IgG molecule possesses both the F(c) region, recognized by high-affinity Fc receptor proteins, as well as the F(ab) region possessing the epitope-recognition site. Both the Heavy and Light chains of the antibody molecule are present. Secondary Antibodies are available in a variety of formats and conjugate types. When choosing a secondary antibody product, consideration must be given to species and immunoglobulin specificity, conjugate type, fragment and chain specificity, level of cross-reactivity, and host-species source and fragment
Goat Anti-Human IgG IgA IgM [ALP],pAb- GenScript, AAALAC International Accredited Animal FacilityGoat Anti-Human IgG IgA IgM [ALP],pAb- GenScript, AAALAC International Accredited Animal Facility
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Human antibodies, TEM - Stock Image P270/0063 - Science Photo LibraryHuman antibodies, TEM - Stock Image P270/0063 - Science Photo Library
Human antibodies (yellow), coloured transmission electron micrograph (TEM). The Y-shaped structures are molecules of the immunoglobulin G (IgG) antibody. Antibodies are part of the immune system, helping to defend the body against infection by binding to foreign proteins. IgG antibodies are produced by B-lymphocyte blood cells, and they are found in the liquid plasma component of the blood. - Stock Image P270/0063
Anti-Human Immunoglobulin | BiotiumAnti-Human Immunoglobulin | Biotium
From: $106 Sizes: 5-20 ug labeling, 10-20 ug labeling, 20-50 ug labeling, 25-50 ug labeling, 50-100 ug labelingCatalog #: 92433, 92432, 92431, 92430, 92429, 92428, 92427, 92426, 92425, 92230, 92231, 92232, 92233, 92234, 92235, 92236, 92237, 92238, 92239, 92240, 92241, 92242, 92243, 92245, 92246, 92247, 92248, 92250, 92251, 92252, 92253, 92254, 92255, 92256, 92257, 92258, 92259, 92260, 92261, 92262, 92263, 92264, 92265, 92267, 92268, 92270, 92271, 92272, 92273, 92274, 92275, 92276, 92277, 92278, 92279, 92280, 92281, 92282, 92283, 92284, 92285, 92287, 92288, 92289, 92290, 92291, 92303, 92304, 92305, 92316, 92317, 92318, 92319, 92320, 92321, 92322, 92323, 92324, 92331, 92332, 92333, 92334, 92335, 92336, 92337, 92338, - 92339View allHide ...
Goat Anti-Human IgG (H&L),pAb- GenScript, AAALAC International Accredited Animal FacilityGoat Anti-Human IgG (H&L),pAb- GenScript, AAALAC International Accredited Animal Facility
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Anti-Human Interleukin-22 Receptor (N-Terminal) Antibody - Goat Anti-Human Polyclonal Antibody IHC-P, IF, E - Buy Now! |AbgentAnti-Human Interleukin-22 Receptor (N-Terminal) Antibody - Goat Anti-Human Polyclonal Antibody IHC-P, IF, E - Buy Now! |Abgent
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Rabbit Anti-Human IgG Secondary Antibody, HRP ConjugateRabbit Anti-Human IgG Secondary Antibody, HRP Conjugate
HRP Conjugated Rabbit Anti-human IgG (gamma-chain specific) secondary antibody This HRP conjugated antibody is specific for human IgG and shows no cross-reactivity with rat/mouse/goat/rabbit IgG.
A Number Of Questions That Should Be Asked In Regards To GDC-0449 - Cypher Gate WikiA Number Of Questions That Should Be Asked In Regards To GDC-0449 - Cypher Gate Wiki
Following, we evaluated the result involving opsonization with various IgG subclasses for the amounts of workable intracellular bacterias. Infected THP-1 cellular material were lysed throughout 0��1% Triton X-100 as well as intracellular GDC-0449 mouse viable germs within the lysates have been and then counted through plating upon agar. Opsonization each and every in the IgG subclasses led to a greater number of recovered intra cellular feasible microorganisms than when using the non-specific control antibody. However, small, nevertheless important differences had been known while testing the different IgG subclasses individually. Opsonization using IgG3 led to the very best variety of retrieved intracellular workable germs SB-431542 (5��38?��?0��009 log10?CFU), followed tightly by IgG1 (5��29?��?0��012 log10?CFU), IgG4 (5��17?�� 0��017 log10?CFU) as well as IgG2 (5��02?��?0��011 log10?CFU). The number of recovered intra-cellular workable germs ...
Anti-IgG (H+L) Antibody | Rabbit IgG (H+L) Antibody | Mouse IgG (H+L) AntibodyAnti-IgG (H+L) Antibody | Rabbit IgG (H+L) Antibody | Mouse IgG (H+L) Antibody
These products are affinity-purified IgG antibodies that recognize the heavy and light chains (H+L) of rabbit or mouse immunoglobulin G (IgG) antibodies. They are provided in unlabeled form or as a conjugate with horseradish peroxidase (HRP) enzyme. The antibodies were raised in goat or rabbit using rabbit IgG (H+L) or mouse IgG (H+L), and can be used as a secondary antibody for Western blot (WB) detection, immunohistochemical (IHC) detection, or ELISAs.. ...
Clinical significance of SARS-CoV-2-specific IgG detection with a rapid antibody kit for COVID-19 patients<...Clinical significance of SARS-CoV-2-specific IgG detection with a rapid antibody kit for COVID-19 patients<...
TY - JOUR. T1 - Clinical significance of SARS-CoV-2-specific IgG detection with a rapid antibody kit for COVID-19 patients. AU - Chong, Yong. AU - Ikematsu, Hideyuki. AU - Tani, Naoki. AU - Arimizu, Yoko. AU - Watanabe, Haruka. AU - Fukamachi, Yukako. AU - Yonekawa, Akiko. AU - Iwasaka, Sho. AU - Nishida, Ruriko. AU - Eriguchi, Yoshihiro. AU - Miyake, Noriko. AU - Shimoda, Shinji. AU - Nagasaki, Yoji. AU - Shimono, Nobuyuki. AU - Akashi, Koichi. PY - 2020. Y1 - 2020. N2 - Background: The longitudinal observation of the detection of antibody responses to SARS-CoV-2 using antibody kits during the clinical course of COVID-19 is not yet fully investigated. Objectives: To understand the significance of the detection of anti-SARS-CoV-2 antibodies, particularly IgG, using a rapid antibody kit, during the clinical course of COVID-19 patients with different severities. Methods: Sixty-three serum samples from 18 patients (5 asymptomatic and 13 symptomatic patients) were retrospectively examined using a ...
ADAM15 Rabbit Polyclonal IgG AntibodyADAM15 Rabbit Polyclonal IgG Antibody
Research proven ADAM15 Rabbit Polyclonal IgG Antibody. Immunohistochemistry, Western Blot, Immunocytochemistry, and Immunofluorescence applications. Human, mouse, and rat specificity
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Mar 25, 2017 · IgM is the first antibody to be produced in response to any antigen (foreign particle) invasion, while IgG is most abundantly found antibody in the human body. IgM is the largest immunoglobulin among all, with pentamer units and ten antigens binding site. IgG are responsible for humoral immunity and is a monomer unit which is lighter and smaller, with two antigen binding site ...
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Mar 25, 2017 · IgM is the first antibody to be produced in response to any antigen (foreign particle) invasion, while IgG is most abundantly found antibody in the human body. IgM is the largest immunoglobulin among all, with pentamer units and ten antigens binding site. IgG are responsible for humoral immunity and is a monomer unit which is lighter and smaller, with two antigen binding site.. ...
Rabbit IgG Fraction To Human IgG (Whole Molecule)Rabbit IgG Fraction To Human IgG (Whole Molecule)
Product is the lyophilized powder of rabbit IgG fraction to human IgG (whole molecule) and buffer salts. The IgG fraction is prepared from the specific rabbit antiserum by delipidation, ammonium sulfate fractionation and anion exchange chromatography. The resulting IgG fraction is dialyzed into 0.02M sodium phosphate, 0.14M sodium chloride, pH 7.3, adjusted to standard titer, filtered through a 0.22 µm filter, vialed and lyophilized.
Anti-HSPA5 / GRP78 / BiP Antibody (C-Terminus) - Rabbit Anti Human Polyclonal Antibody WB, IHC-P, IF, ICC, IP - Buy Now! |AbgentAnti-HSPA5 / GRP78 / BiP Antibody (C-Terminus) - Rabbit Anti Human Polyclonal Antibody WB, IHC-P, IF, ICC, IP - Buy Now! |Abgent
Anti-HSPA5 / GRP78 / BiP Antibody (C-Terminus), Rabbit Anti Human Polyclonal Antibody validated in WB, IHC-P, IF, ICC, IP (ALS18255), Abgent
Gentaur Molecular :Nordic Immunological Lab \ sheep IgG against rat IgG Fab, conjugated with FITC \ ShARa/Fab/FITCGentaur Molecular :Nordic Immunological Lab \ sheep IgG against rat IgG Fab, conjugated with FITC \ ShARa/Fab/FITC
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Use of Fourier-transform infrared spectroscopy to quantify immunoglobulin G concentration and an analysis of the effect of...Use of Fourier-transform infrared spectroscopy to quantify immunoglobulin G concentration and an analysis of the effect of...
Use of Fourier-transform infrared spectroscopy to quantify immunoglobulin G concentration and an analysis of the effect of signalment on levels in canine serum
Engineering of Fc(1) and Fc(3) from human immunoglobulin G to analyse subclass specificity for staphylococcal protein A.Engineering of Fc(1) and Fc(3) from human immunoglobulin G to analyse subclass specificity for staphylococcal protein A.
A system for production of recombinant Fc fragments of human IgG in Escherichia coli has been developed to allow for structural and functional studies of human Fc. The genes for the Fc fragments of human IgG subclasses 1 and 3, designated Fc(1) and Fc(3), were cloned from a human spleen cDNA library. The interactions to Staphylococcal protein A (SpA), a bacterial Fc receptor, that interacts with human IgG-Fc(1), but not with human IgG-Fc(3), were analyzed. To corroborate the involvement of amino acid residues in Fc, responsible for these differences in binding, two Fc variants were constructed; Fc(1(3)) and Fc(3(1)), each containing an isotypic dipeptide substitution. Production levels in E. coli of 1-10 mg/l of secreted Fc proteins, covalently linked as dimers, were routinely obtained. SpA-binding analyses of all four Fc variants using biosensor technology, showed that Fc(1) and Fc(3(1)) interact with SpA, while Fc(3) and Fc(1(3)) lack detectable SpA binding. The rendered SpA binding of the Fc ...
Naturally acquired immunoglobulin (Ig)G subclass antibodies to crude asexual Plasmodium falciparum lysates: evidence for...Naturally acquired immunoglobulin (Ig)G subclass antibodies to crude asexual Plasmodium falciparum lysates: evidence for...
There is longstanding evidence for a role of immunoglobulin (Ig)G in protection against malarial disease and infection. IgG1 and IgG3 have been shown to be particularly efficient at associating with monocytes in potentially protective mechanisms (i.e. antibody-dependent cellular inhibition, opsonization and phagocytosis). Conversely, there is some evidence that IgG2 (and possibly IgG4) antibodies may be antagonistic to this protection. The protective effect of IgG subclass antibody activity present before the beginning of a malaria transmission season (preseason antibody levels) against severe malaria has not been tested in longitudinal studies. We measured IgG class and subclass antibody levels specific to crude Plasmodium falciparum lysates by enzyme linked immunosorbent assay in a case-control study of 76 children on the coast of Kenya. The mean optical density values for both IgG class and subclass antibodies were not significantly different between the children who developed severe malaria ...
IgG subclass serum levels in juvenile chronic arthritis. | Annals of the Rheumatic DiseasesIgG subclass serum levels in juvenile chronic arthritis. | Annals of the Rheumatic Diseases
IgG subclass levels of sera from 26 patients with juvenile chronic arthritis (JCA) were determined by means of mouse monoclonal antibodies. Patients were divided into three groups according to clinical activity of the disease: active disease, partial remission, and remission. One hundred and sixty four age matched, healthy children served as controls. IgG subclass concentrations were log transformed, and a robust regression method was applied to obtain expected values for the different ages. We found a significant increase of IgG3 (p less than 0.0001), IgG1 (p less than 0.002), and IgG2 (p less than 0.035) in JCA sera, while IgG4 values did not differ significantly from those of controls. When patients were divided according to clinical activity significant increases of IgG2 and IgG4 were observed in the patients in partial remission. Our data suggest that differential increase of IgG subclasses during the courses of JCA may be of relevance to the pathogenesis of the disease. ...
Antimitochondrial antibodies of immunoglobulin G3 subclass are associated with a more severe disease course in primary biliary...Antimitochondrial antibodies of immunoglobulin G3 subclass are associated with a more severe disease course in primary biliary...
Background/Aims: Primary biliary cirrhosis (PBC) is characterised by the presence of immunoglobulin (Ig) G antimitochondrial antibodies (AMA), which are routinely detected by indirect immunofluorescence (IFL) using composite rodent tissue substrate. The IgG subclass distribution and clinical significance of IFL-detected AMA in patients with PBC have not been previously studied in detail.. Methods: We have examined IgG subclass-specific AMA detected by IFL on rodent liver, kidney and stomach tissue substrate using affinity-purified IgG subclass monospecific antisera as revealing reagents in 95 AMA-positive PBC patients from Greece.. Results: AMA of any of the IgG1, IgG2 or IgG3 subclasses were present in 89/95 (93.7%) patients. Among those 89, 55 (61.8%) had IgG1, 2, 3 AMA positivity; eight (9%) had IgG1, 2; seven (7.9%) had IgG2, 3; eight (9%) had IgG1, 3; nine (10.1%) had IgG1 subclass and two (2.2%) single IgG3 AMA reactivity. IgG4 AMA was absent. IgG3 titres were higher than IgG2 and IgG1 ...
Virus-neutralizing antibodies of immunoglobulin G (IgG) but not of IgM or IgA isotypes can cure influenza virus pneumonia in...Virus-neutralizing antibodies of immunoglobulin G (IgG) but not of IgM or IgA isotypes can cure influenza virus pneumonia in...
The ability of monoclonal antibodies (MAbs) to passively cure an influenza virus pneumonia in the absence of endogenous T- and B-cell responses was investigated by treating C.B-17 mice, homozygous for the severe combined immunodeficiency (SCID) mutation, with individual monoclonal antiviral antibodies 1 day after pulmonary infection with influenza virus PR8 [A/PR/8/34 (H1N1)]. Less than 10% of untreated SCID mice survived the infection. By contrast, 100% of infected SCID mice that had been treated with a single intraperitoneal inoculation of at least 175 micrograms of a pool of virus-neutralizing (VN+) antihemagglutinin (anti-HA) MAbs survived, even if antibody treatment was delayed up to 7 days after infection. The use of individual MAbs showed that recovery could be achieved by VN+ anti-HA MAbs of the immunoglobulin G1 (IgG1), IgG2a, IgG2b, and IgG3 isotypes but not by VN+ anti-HA MAbs of the IgA and IgM isotypes, even if the latter were used in a chronic treatment protocol to compensate for ...
Goat Anti-Human kappa ( chain specific) Absorbed against mouse IgsGoat Anti-Human kappa ( chain specific) Absorbed against mouse Igs
... , Goat Anti-Human Kappa, Mouse ads-TRITC; N/A Goat Anti-Human kappa ( chain specific) Absorbed against mouse Igskappa
CRIM1 Goat anti-Human, Polyclonal, R&D Systems™ 100μg; Unlabeled CRIM1 Goat anti-Human, Polyclonal, R&D Systems™CRIM1 Goat anti-Human, Polyclonal, R&D Systems™ 100μg; Unlabeled CRIM1 Goat anti-Human, Polyclonal, R&D Systems™
CRIM1 Goat anti-Human, Polyclonal, R&D Systems™ 100μg; Unlabeled CRIM1 Goat anti-Human, Polyclonal, R&D Systems™ Primary Antibodies Ci to Cx
Influenza virus nucleoprotein-specific immunoglobulin G subclass and cytokine responses elicited by DNA vaccination are...Influenza virus nucleoprotein-specific immunoglobulin G subclass and cytokine responses elicited by DNA vaccination are...
Endpoint immunoglobulin G (IgG) titers and cytotoxic T-lymphocyte (CTL) activities were identical between mice immunized via the intramuscular and epidermal (gene gun) routes with 100 and 1 micrograms, respectively, of an influenza virus nucleoprotein (NP) expression vector. However, examination of the relative levels of two IgG subclasses demonstrated that muscle inoculation resulted in predominantly IgG2a responses, whereas gene gun immunization yielded a preponderance of IgG1 antibodies. Inasmuch as these data suggested that muscle inoculation and gene gun delivery elicited Th1-like and Th2-like responses, respectively, gamma interferon release profiles from antigen-stimulated splenocytes were remarkably similar between these groups. Interleukin-4 (IL-4) production assays, on the other hand, revealed qualitative differences that could be correlated with the divergent IgG subclass data. Waning gamma interferon production in gene gun-immunized animals was countered by a marked increase in IL-4 ...
Human polyclonal immunoglobulin G from transchromosomic bovines inhibits MERS-CoV in vivo | Science Translational MedicineHuman polyclonal immunoglobulin G from transchromosomic bovines inhibits MERS-CoV in vivo | Science Translational Medicine
Acknowledgments: The views expressed in this article are those of the authors and do not necessarily reflect the official policy or position of the Department of the Navy, Department of Defense, Department of Health and Human Services, or of the institutions and companies affiliated with the authors. Some of the authors are employees of the U.S. Government, and this work was prepared as part of their official duties. Title 17 United States Code (U.S.C.) s105 provides that "Copyright protection under this title is not available for any work of the United States Government." Title 17 U.S.C. s101 defines a U.S. Government work as a work prepared by a military service member or employee of the U.S. Government as part of that persons official duties. The Jordan-N3/2012 strain (GenBank KC776174.1) of MERS-CoV was isolated and provided by G. Defang (Naval Medical Research Unit-3, Ca7iro, Egypt) (39). The clinical sample from which the MERS-CoV Jordan-N3/2012 strain was isolated was provided by T. ...
Inverse relation between vitamin D and serum total immunoglobulin G in the Scandinavian Cystic Fibrosis Nutritional StudyInverse relation between vitamin D and serum total immunoglobulin G in the Scandinavian Cystic Fibrosis Nutritional Study
Background/Objectives: The hallmark of cystic fibrosis (CF) is chronic lung inflammation. The severity of lung disease is closely correlated with immunoglobulin G (IgG) levels. Beyond its contribution to the bone health, the importance of vitamin D has not been fully recognized owing to the lack of human studies providing evidence of its benefit. In the context of the recently described immunomodulatory functions of vitamin D, we aimed to assess the relationship between vitamin D and IgG levels. Subjects/Methods: Eight hundred and ninety-six CF patients were included (0.53-65.9 years) from seven centers in Denmark, Norway and Sweden. Serum 25-hydroxyvitamin D (25OHD) and total IgG were measured, spirometry was carried out and vitamin D intake data were gathered using a 7-day dietary food record. Multiple linear regression analyses were performed for IgG and forced expiratory volume in 1 lambda s (FEV1) as dependent variables, and serum 25OHD, daily food and supplemented vitamin D sources of ...
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2019-nCoV IgG/IgM Rapid Test (Single Use Kit) - ELISA medical supply rapid dengue igg igm igm rapid test kit. Description 2019-nCoV IgG/IgM Rapid Tests 2019-nCoV IgG/IgM Rapid Test (Single Use Kit) The 2019-nCoV IgG/IgM Rapid Test Cassette is a lateral flow chromatographic immunoassay for the qualitative detection of IgG and IgM antibodies to 2019-nCoV in human whole blood, serum or plasma supply hot igg igm rapid test kit price ...
Contribution of IgG Subclass and Heavy Chain Constant Region Domains to Affinity and Protective Activity of mAbs Specific to...Contribution of IgG Subclass and Heavy Chain Constant Region Domains to Affinity and Protective Activity of mAbs Specific to...
Bacillus anthracis, the causative agent of anthrax, is surrounded by an antiphagocytic capsule composed of poly-£^-D-glutamic acid (£^DPGA). Antibodies directed against the £^DPGA capsule are opsonic and protective, which makes the capsule an attractive target for vaccine development. However, antibodies of different IgG subclasses differ in their ability to activate effector functions, including activation of complement and phagocytosis. In addition, recent studies found differences in affinity and protective activity between variable region identical IgG subclass switch monoclonal antibodies (mAbs) directed against microbial capsules or outer membrane proteins. We recently generated six mAbs against the £^DPGA capsule and found that only mAbs of IgG3 subclass were protective in a murine model of inhalational anthrax. In order to investigate the role of IgG subclass to protective activity against anthrax, the goal of the study was to generate a full IgG subclass switch family (IgG3 ,,³ ...
Clinical Indications of Intravenous Immunoglobulin Use in Pediatric Infectious Diseases Clinic | AVESİSClinical Indications of Intravenous Immunoglobulin Use in Pediatric Infectious Diseases Clinic | AVESİS
Objective: Intravenous immunoglobulin (IVIG) is a human polyclonal IgG preparation developed for the treatment of patients with primary immunodeficiency (PID). Because of the anti-inflammatory and immunomodulatory effects of IVIG, beyond PID now IVIG is widely used in autoimmune and inflammatory diseases. The aim of this study was to determine the demographic characteristics of patients treated with IVIG treatment in the pediatric infectious diseases clinic, and to evaluate the indications, side effects and treatment outcomes of IVIG treatment. ...
Vaccination in Pregnancy-Recent Developments : The Pediatric Infectious Disease JournalVaccination in Pregnancy-Recent Developments : The Pediatric Infectious Disease Journal
Immunoglobulin G (IgG) is the only antibody isotype actively transferred across the placenta from around 13 weeks of gestation and increases exponentially during the third trimester such that the concentration of IgG in the newborn infant is similar to, or exceeds, that in the mother. IgG provides passive immunity to the infant in the first months of life.. The neonatal Fc receptor facilitates transcytosis of maternal IgG. IgG is transferred from maternal blood across the syncytiotrophoblast layer of the placenta, initially by endocytosis of IgG. Within the acidic endosome, IgG binds to membrane-bound neonatal Fc receptor, which is then released on the fetal side of the syncytiotrophoblast as the pH returns to physiologic pH. Neonatal Fc receptor is then recycled back to the maternal side of the syncytiotrophoblast to bind further IgG.. There are a number of factors that may affect the efficiency of IgG transcytosis, including gestation, IgG subclass and maternal infection.1 The concentration of ...
Goat Anti-Human IgA, alpha chain Antibody, Colloidal Gold Conjugated, 50 ODGoat Anti-Human IgA, alpha chain Antibody, Colloidal Gold Conjugated, 50 OD
... ,Colloidal Gold Conjugated, Goat anti-human IgA (Alpha Chain) - 50 OD,medicine,medical supply,medical supplies,medical product
922 - Diphtheria Antibody IgG - Viracor Eurofins922 - Diphtheria Antibody IgG - Viracor Eurofins
Your trusted lab partner for Diphtheria Antibody IgG testing, Viracor Eurofins delivers your results faster, when it matters most.
Loci Associated with N-Glycosylation of Human Immunoglobulin G Show Pleiotropy with Autoimmune Diseases and Haematological...Loci Associated with N-Glycosylation of Human Immunoglobulin G Show Pleiotropy with Autoimmune Diseases and Haematological...
Author Summary After analysing glycans attached to human immunoglobulin G in 4,095 individuals, we performed the first genome-wide association study (GWAS) of the glycome of an individual protein. Nine genetic loci were found to associate with glycans with genome-wide significance. Of these, four were enzymes that directly participate in IgG glycosylation, thus the observed associations were biologically founded. The remaining five genetic loci were not previously implicated in protein glycosylation, but the most of them have been reported to be relevant for autoimmune and inflammatory conditions and/or haematological cancers. A particularly interesting gene, IKZF1 was found to be associated with multiple IgG N-glycans. This gene has been implicated in numerous diseases, including systemic lupus erythematosus (SLE). We analysed N-glycans in 101 cases with SLE and 183 matched controls and demonstrated their substantial biomarker potential. Our study shows that it is possible to identify new loci that
Anti-IgG (H+L) Antibody | Rabbit IgG (H+L) Antibody | Mouse IgG (H+L) AntibodyAnti-IgG (H+L) Antibody | Rabbit IgG (H+L) Antibody | Mouse IgG (H+L) Antibody
These products are affinity-purified IgG antibodies that recognize the heavy and light chains (H+L) of rabbit or mouse immunoglobulin G (IgG) antibodies. They are provided in unlabeled form or as a conjugate with horseradish peroxidase (HRP) enzyme. The antibodies were raised in goat or rabbit using rabbit IgG (H+L) or mouse IgG (H+L), and can be used as a secondary antibody for Western blot (WB) detection, immunohistochemical (IHC) detection, or ELISAs.. ...
Changes of immunoglobulin G glycosylation with age | Nacionalni repozitorij disertacija i znanstvenih magistarskih radovaChanges of immunoglobulin G glycosylation with age | Nacionalni repozitorij disertacija i znanstvenih magistarskih radova
In this thesis, glycosylation of immunoglobulin G (IgG) was examined in 5818 individuals ranging in age from 16 to 100 years from five different populations - four European populations and a Han Chinese population by using ultra performance liquid chromatography (UPLC) in order to provide a comprehensive overview of changes in IgG glycosylation through lifetime. The results demonstrated that glycan profiles change in a similar way through lifetime across all examined populations. Nearly all IgG glycans were significantly associated with age. Sex differences in age-related changes in IgG glycosylation were observed. The combination of several IgG glycans was able to explain from 30 to 58% of variance in chronological age, with the remaining variance in the glycans attributed to physiological parameters. Analysis of IgG glycosylation in nearly 600 mice from the Collaborative Cross cohort ranging in age from 20 to 80 weeks showed that, generally, only the level of IgG glycan with ...
Immunoglobulin G-binding protein elisa and antibodyImmunoglobulin G-binding protein elisa and antibody
Shop Immunoglobulin G-binding protein ELISA Kit, Recombinant Protein and Immunoglobulin G-binding protein Antibody at MyBioSource. Custom ELISA Kit, Recombinant Protein and Antibody are available.
Human IgG F(ab)2 Antibody 209-1104Human IgG F(ab')2 Antibody 209-1104
Anti-Human IgG F(ab)2 Antibody generated in goat recognizes the dimeric Fab portion of the human IgG molecule. Human IgG F(ab)2 is a proteolytic fragment of immunoglobulin G (IgG) obtained by limited digestion with the enzyme pepsin under controlled conditions of temperature, time and pH. F(ab)2 molecules lack the Fc portion of IgG and therefore receptors that bind human IgG F(c) will not bind human IgG F(ab)2 molecules. Secondary Antibodies are available in a variety of formats and conjugate types. When choosing a secondary antibody product, consideration must be given to species and immunoglobulin specificity, conjugate type, fragment and chain specificity, level of cross-reactivity, and host-species source and fragment composition.
The First Clinical Use of a Recombinant Lactococcus lactis Expressing Human Papillomavirus Type 16 E7 Oncogene Oral Vaccine: A...The First Clinical Use of a Recombinant Lactococcus lactis Expressing Human Papillomavirus Type 16 E7 Oncogene Oral Vaccine: A...
Figure 2. HPV-16 E7-specific serum IgG antibody (1, top) and E7-specific vaginal IgA antibody (2, bottom) levels by placebo groups [cohorts 1 (A, left); 1 × 109 CFU/mL dose, cohorts 2 (B, center); 5 × 109 CFU/mL dose, and cohorts 3 (C, right); 1 × 1010 CFU/mL dose] and vaccine group [cohorts 4 (A, left); 1 × 109 CFU/mL dose, cohorts 5 (B, center); 5 × 109 CFU/mL dose, and cohorts 6 (C, right); 1 × 1010 CFU/mL dose] measured by ELISA at a serum dilution of 1:100 using goat anti-human IgG H&L (HRP) antibody and at a vaginal fluid dilution of 1:10 using goat anti-human IgA alpha chain (HRP) antibody, respectively. Results are expressed with 95% CIs for the following time points: prevaccination (day 0), days 30, 60, 90, and 240. The absorbance of each well was measured at 450 nm. Bars represent the mean ± standard error value of each group. Statistically significant differences are denoted by an asterisk between T60 and T30, T90, and T240 of vaccine groups (*, P ≤ 0.0001; **, P ≤ 0.001; ...
The presence of two fc receptors on mouse macrophages. Evidence from a by J C. Unkeless"The presence of two fc receptors on mouse macrophages. Evidence from a" by J C. Unkeless
Unkeless, J C., "The presence of two fc receptors on mouse macrophages. Evidence from a variant cell line and differential trypsin sensitivity." (1977). Subject Strain Bibliography 1977. 2386 ...
JCI Insight - Anti-myeloperoxidase antibodies attenuate the monocyte response to LPS and shape macrophage developmentJCI Insight - Anti-myeloperoxidase antibodies attenuate the monocyte response to LPS and shape macrophage development
Purification of IgG from patients and controls and generation of F(ab)2 fragments. Blood or plasma exchange fluid was obtained from patients with ANCA vasculitis or healthy controls and plasma stored at -80°C. Fibrinogen was precipitated by adding 18 g/100 ml of sodium chloride and IgG was purified with protein G chromatography (GE Healthcare). The endotoxin concentration in the final IgG preparations was measured by Lonza using a LAL kinetic chromogenic assay. For all 30 polyclonal IgGs used, the endotoxin was less than 0.25 eU/250 μg IgG. The concentration of IgG used for all neutrophil and monocyte assays was 250 μg/ml. To generate F(ab)2 fragments, whole IgG was buffer exchanged using PD10 columns into 20 mM sodium acetate and digested using immobilized pepsin (Thermo Fisher Scientific). The F(ab)2 fragments were separated from undigested IgG using protein A affinity columns (GE Healthcare). SDS-PAGE demonstrated the purity of whole IgG and the F(ab)2 fragments. Before all assays, IgG ...
Immunoglobulin G4-related disease in Hong Kong: clinical features, treatment practices, and its association with multisystem...Immunoglobulin G4-related disease in Hong Kong: clinical features, treatment practices, and its association with multisystem...
In this study, we describe the clinical features and treatment practices of the largest cohort of IgG4-RD in our locality. After combination of our patients with all other published cases of IgG4-RD from Hong Kong, we analysed 104 cases comprising predominantly older men (mean age, 62 ± 13 years; male-to-female ratio=3:1), which is consistent with other reports.19 20 21 22 Over 95% of patients had serum IgG4 level of ,135 mg/dL and an IgG4:IgG ratio of ,8%. Although these cut-offs are often quoted in the diagnostic criteria for IgG4-RD,4 23 it is important to note that elevated serum IgG4 levels can be seen in a variety of other conditions such as malignancies, infections, or autoimmune disorders. Serum IgG4 level and IgG4:IgG ratio alone have poor specificity and low positive predictive value. The specificity and positive predictive value of serum IgG4 and IgG4:IgG ratio have been reported to be approximately only 0.6 and 0.3, respectively.24 Of note, 4/72 (5.6%) of our patients with ...
Goat Anti-Human IgM+IgG+IgA Antibody, F(ab)2 | AQ503Goat Anti-Human IgM+IgG+IgA Antibody, F(ab')2 | AQ503
This Goat anti-Human IgM+IgG+IgA Antibody, F(ab)2 is validated for use in ELISA for the detection of Human IgM+IgG+IgA. Find MSDS or SDS, a COA, data sheets and more information.
Hypoglycaemia after initiation of treatment with etanercept in a patient with type 2 diabetes mellitus | Annals of the...Hypoglycaemia after initiation of treatment with etanercept in a patient with type 2 diabetes mellitus | Annals of the...
Etanercept, a dimeric fusion protein consisting of the extracellular portion of the human p75 tumour necrosis factor α (TNFα) receptor and the Fc receptor of human immunoglobulin G subclass 1, has been used for the treatment of a variety of rheumatological conditions such as rheumatoid arthritis (RA), psoriatic arthritis, and ankylosing spondylitis.1. We report the case of a 54 year old white woman with a longstanding history of RA and type 2 diabetes mellitus who developed episodes of hypoglycaemia after initiation of etanercept treatment. The episodes occurred only on ...
Vasoactive side effects of intravenous immunoglobulin preparations in a rat model and their treatment with recombinant platelet...Vasoactive side effects of intravenous immunoglobulin preparations in a rat model and their treatment with recombinant platelet...
In this study, we compared the vasoactive effects of 16 intravenous immunoglobulin (IVIG) products from 10 different manufacturers, in anesthetized rats. Eight of the IVIG preparations showed no hypotensive effects (less than 15% decrease), whereas the other 8 had relatively strong effects (15%-50% decrease). The hypotensive effects correlated with the IgG dimer content of the preparations. Pretreatment of the rats with recombinant PAF acetylhydrolase completely prevented the hypotensive reaction on IVIG infusion, and administration after the onset of hypotension resulted in normalization of the blood pressure ...
Evidence of immunoglobulin g 1 and immunoglobulin g 2 antibodies in capivara hydrochoerus hydrochaerisEvidence of immunoglobulin g 1 and immunoglobulin g 2 antibodies in capivara hydrochoerus hydrochaeris
Oliveira B.; Marangoni S.; Araujo A.L.; Soares M.A., 1985: Evidence of immunoglobulin g 1 and immunoglobulin g 2 antibodies in capivara hydrochoerus hydrochaeris
Regulation of IgG antibody-dependent cellular cytotoxicity in vitro by IgM antibodies. Mechanism and characterization of...Regulation of IgG antibody-dependent cellular cytotoxicity in vitro by IgM antibodies. Mechanism and characterization of...
TY - JOUR. T1 - Regulation of IgG antibody-dependent cellular cytotoxicity in vitro by IgM antibodies. Mechanism and characterization of effector lymphocytes. AU - Perlmann, H.. AU - Perlmann, P.. AU - Moretta, L.. AU - Ronnholm, M.. PY - 1981. Y1 - 1981. N2 - IgM antibodies have previously been reported to either inhibit or induce antibody-dependent lymphocyte cytotoxicity (ADCC). Here the authors show that human lymphocytes lyse bovine erythrocytes (Eb) in the presence of either IgM or IgG anti-Eb from rabbits. Seven out of 20 IgM preparations (Sephadex G-200) were ADCC-active. IgG-dependent ADCC was inhibited by human IgG but not by IgM. In contrast, IgM ADCC was inhibited by both IgG and IgM. The effector cells in IgM ADCC were a subpopulation of lymphocytes with distinct Fc receptors for both IgG and IgM. Most of them also had sheep erythrocyte receptors. Extensive purification of the ADCC-active IgM antibody preparations indicated that very small amounts of contaminating IgG anti-Eb were ...
Evaluation of Recombinant Dense Granule Antigen 7 (GRA7) of Toxoplasma gondii for Detection of Immunoglobulin G Antibodies and...Evaluation of Recombinant Dense Granule Antigen 7 (GRA7) of Toxoplasma gondii for Detection of Immunoglobulin G Antibodies and...
Recently, a new dense granule protein (GRA7) from T. gondii was described, and the corresponding gene was characterized (9). To study the potential of this protein for serological assays, the gra7 gene was expressed in E. coliwith a short mTNF fragment and hexahistidine as a fusion partner. The subsequent purification of the recombinant protein allowed evaluation of this antigen as a diagnostic tool. In an indirect IgG ELISA, a sensitivity of 81% and a specificity of 98% were reached. High-titer IgG-positive sera (IF titer, ,1/1,024) were readily detected (100%). IgM-positive sera were detected in 94% of cases, and for chronic-phase sera (IgM negative) the sensitivity was 79%. In general, chronic-stage sera with low IgG titers by IF were more difficult to detect with GRA7. These results were in the same range as those obtained for a recombinant fragment of GRA2 (75% for chronic-phase sera, 82.6% for acute-phase sera) (17) and for Tg34AR (ROP2 fragment; 89% overall sensitivity) (27). The ...
Salivary IgA Subclass Antibodies to Candida - Fruit and VegetableSalivary IgA Subclass Antibodies to Candida - Fruit and Vegetable
IgA subclass antibodies have been reported in a few studies in patients with CAC. IgA antibodies and IgA1 antibodies were increased in comparison with the
Tau Mouse Monoclonal IgG AntibodyTau Mouse Monoclonal IgG Antibody
... Immunofluorescent (IF), Immunocytochemistry (ICC), Immunohistochemistry (IHC), and Western Blot (WB) applications. Species are human, rat, and mouse
Goat Anti-Human IgG Fc (DyLight® 594) preadsorbed (ab98621)Goat Anti-Human IgG Fc (DyLight® 594) preadsorbed (ab98621)
Anti-Human IgG Fc DyLight® 594 preadsorbed (cross-adsorbed) validated for IHC-P, Flow Cyt, ICC/IF. Other DyLight® 594 secondaries available.
Elevated IgG Antibody - Digestive conditions - Condition | Our HealthElevated IgG Antibody - Digestive conditions - Condition | Our Health
I was found to have an increased IgG protein level on a urinalysis my doctor recommended that I have an SPEP (Serum Protein Electrophoresis) done, maybe you should ask about having that test done and then go from there with your doctor regarding the results. Best wishes ...
Anti-Human IgG AlphaPlex 645 (Sm) Acceptor beads, 25 mg| PerkinElmerAnti-Human IgG AlphaPlex 645 (Sm) Acceptor beads, 25 mg| PerkinElmer
AlphaPlex-645 (Samarium) beads conjugated to anti-human IgG antibody, for binding human IgG antibodies in AlphaPlex multiplexing no-wash assays
Lymphocyte membrane IgG and secreted IgG are structurally and allotypically distinct. | JEMLymphocyte membrane IgG and secreted IgG are structurally and allotypically distinct. | JEM
We have demonstrated that there are structurally distinct membrane and secreted IgG2a immunoglobulin molecules. The membrane heavy chain is both larger and more acidic than the secreted molecule. This difference is not a result of different N-glycosidic-linked oligosaccharide chains. The membrane heavy chain also is antigenically different from its secreted homologue. This is based on the fact that secreted IgG2a molecules express an allotypic determinant absent on membrane molecules. We discussed the genetic control and gene organization of membrane and secreted immunoglobulin heavy chain sequences and suggest mechanisms controlling the expression of the simian virus 40 genome as models for alternate gene expression of membrane and secreted heavy chain polypeptide chains from the same DNA sequence. The possible biological significance of the membrane immunoglobulin acting as a recognition site for regulatory T cells also is discussed. The difference between membrane and secreted immunoglobulin ...
PWE-017 High prevalence of subclass-specific binding and neutralising antibodies against clostridium difficile toxins in adult...PWE-017 High prevalence of subclass-specific binding and neutralising antibodies against clostridium difficile toxins in adult...
Method Subclass-specific IgA and IgG responses to highly purified whole CD toxins A and B (toxinotype 0, strain VPI 10463, ribotype 087; toxin A 200 µg/mL, toxin B 100 µg/mL), toxin B from a CD toxin-B only expressing strain (CCUG 20309, 90 µg/mL) and precursor form of B fragment of binary toxin, pCDTb (200 µg/mL), were determined by a validated protein microarray assay. NAb to CD toxins A and B were evaluated using a Caco-2 cell neutralisation assay. Clinical and demographic information was collected from medical records. All statistical analyses were performed on natural log-transformed data using GraphPad Prism version 6. For grouped multiple comparisons, the Kruskall-Wallis test and the Dunns post hoc test was applied; p≤0.05 was statistically significant. ...
COVID-19 Antibody Test now available at Hope Medical - Maxsthetica InternationalCOVID-19 Antibody Test now available at Hope Medical - Maxsthetica International
Get COVID tested by our pharmacist in the safe CQC premises of Hope Medical. The COVID-19 Rapid Test detects IgM and IgG antibodies to the SARS-CoV-2 virus in human whole blood, serum and plasma specimens.. Immunoglobulin G (IgG) is the most common antibody. Its in blood and other body fluids, and protects against bacterial and viral infections. IgG can take time to form after an infection or immunization.. Immunoglobulin M (IgM) is found mainly in blood and lymph fluid, this is the first antibody the body makes when it fights a new infection.. Procured by a reputable pharmaceutical company, the COVID-19 Rapid Test was compared with PCR and as shown the accuracy is above 90% for both IgM and IgG. (More information on the comparative testing can be provided on request). It is important to note that the COVID19 antibody test identifies if the body has developed an antibody response to a COVID19 infection. The test is not a viral test to identify if there is a current infection.. Results are ...
GM phenotypes influence the concentrations of the four subclasses of immunoglobulin G in normal human serum. - PubMed - NCBIGM phenotypes influence the concentrations of the four subclasses of immunoglobulin G in normal human serum. - PubMed - NCBI
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Human IgG - Biocare MedicalHuman IgG - Biocare Medical
Immunoglobulin G (IgG) is an antibody isotype secreted by plasma cells and composed of four peptide chains - two identical heavy chains and two identical light chains arranged in a Y-shape typical of antibody monomers (1). In humans, IgG consists of four subclasses that differ only marginally in their amino acid composition (1). Representing approximately 75% of serum immunoglobulins in humans, IgG is the most abundant antibody isotype found in the circulation (1). Anti-IgG had been proven useful in the assessment of renal biopsies (2), autoimmune disorders (3), in the identification of plasma cell neoplasms (4) and in non-Hodgkin lymphomas (5). The ratio of IgG4+ plasma cells to IgG+ plasma cells has been considered important in making a diagnosis of IgG4-related disorders (6).. ...
Mouse Anti-Human IgG beads mouse anti-human IgG-16A - Creative BioMartMouse Anti-Human IgG beads mouse anti-human IgG-16A - Creative BioMart
This product contains sepharose beads coated with mouse anti-human IgG. Mouse anti-human IgG is affinity purified and conjugated to the beads at 1-1.5 mg/ml ratio. The beads may be used for purification of human IgG class of antibodies or proteins. The be
Abbkine Scientific launches new resin - PurKine™ Protein A/G Resin 4FF | Richmond News NowAbbkine Scientific launches new resin - PurKine™ Protein A/G Resin 4FF | Richmond News Now
PurKine™ Protein A/G Resin 4FF is the latest addition to the Abbkine resin family. The product otherwise known as Protein A/G Resin is designed to allow for effective and easy purification of IgG from serum, ascites fluid, cell culture supernantant and other such antibody samples.. The chemically modified Recombinant Protein A/G helps to reduce nonspecific binding of proteins, allowing researchers and investigators to get their desired results easily. It also binds perfectly well to all human IgG subclasses as well as all mouse IgG subclasses.. The product has reported to be different from its peers due to the flexbility of use, as it is available in multiple formats including bulk resin, spin columns and complete kits. The Protein A/G Agarose is also available as pre-packed spin column and kit formats. Studies have revealed the cost-effectiveness of the product, with no decrease in performance after up to five repeated uses.. The product has been deliberately made to be used in IgG ...
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IgA specific serine endopeptidaseIgA specific serine endopeptidase
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Immunoglobulins, IntravenousImmunization, PassiveEncyclopedias as TopicReceptors, IgGImmunoglobulinsImmunoglobulin GActinobacillus suisMice, HairlessImmunoglobulin AImmunoglobulin MPemphigoid, Benign Mucous MembraneSalivaImmunoglobulin EAllergensHypersensitivitySkin TestsHypersensitivity, ImmediateDesensitization, ImmunologicAsthmaEncephalomalaciaIgA DeficiencyDysgammaglobulinemiaAgammaglobulinemiaIgG DeficiencyImmunologic Deficiency SyndromesDictionaries, MedicalMeaslesMeasles virusMeasles VaccineDictionaries as TopicCrowdsourcingTerminology as TopicRho(D) Immune GlobulinElectronic MailRh IsoimmunizationErythroblastosis, FetalRh-Hr Blood-Group SystemFetomaternal TransfusionAbortion, ThreatenedCommon Variable ImmunodeficiencyImmunoglobulin Heavy ChainsReceptors, Polymeric ImmunoglobulinSecretory ComponentImmunoglobulin A, SecretoryEpithelial CellsPlasma CellsGenes, ImmunoglobulinDrug LabelingDrug RepositioningProduct LabelingUnited States Food and Drug AdministrationPrescription DrugsSearch Engine
Anti-Human Immunoglobulin | BiotiumAnti-Human Immunoglobulin | Biotium
Molecule of an immunoglobulin G1 antibody - Stock Image P270/0045 - Science Photo LibraryMolecule of an immunoglobulin G1 antibody - Stock Image P270/0045 - Science Photo Library
Immunoglobulin G (IgG), Human Plasma | LeeBio.comImmunoglobulin G (IgG), Human Plasma | LeeBio.com
Immunoglobulin E - WikipediaImmunoglobulin E - Wikipedia
Immunoglobulin therapy - WikipediaImmunoglobulin therapy - Wikipedia
Immunoglobulin AImmunoglobulin A
Immunoglobulin DImmunoglobulin D
The Immunoglobulin a System | SpringerLinkThe Immunoglobulin a System | SpringerLink
Blood Test: Immunoglobulin A (IgA)Blood Test: Immunoglobulin A (IgA)
Antibody Immunoglobulin DiversityAntibody Immunoglobulin Diversity
Immunoglobulin News, ResearchImmunoglobulin News, Research
Immunoglobulin genes (eBook, 1989) [WorldCat.org]Immunoglobulin genes (eBook, 1989) [WorldCat.org]
What is immunoglobulin A (IgA) nephropathy?What is immunoglobulin A (IgA) nephropathy?
Global Immunoglobulin Therapeutics MarketGlobal Immunoglobulin Therapeutics Market
Blood Test: Allergen-Specific Immunoglobulin E (IgE)Blood Test: Allergen-Specific Immunoglobulin E (IgE)
Immunoglobulin Deficiency - symptoms of deficiency?Immunoglobulin Deficiency - symptoms of deficiency?
Measles immunoglobulin definition | Drugs.comMeasles immunoglobulin definition | Drugs.com
Immunoglobulins: Chemical Typing of Immunoglobulins | NatureImmunoglobulins: Chemical Typing of Immunoglobulins | Nature
Thyroid Stimulating ImmunoglobulinThyroid Stimulating Immunoglobulin
Immunoglobulin V regionImmunoglobulin V region
Antenatal prophylaxis with anti-D immunoglobulin | The BMJAntenatal prophylaxis with anti-D immunoglobulin | The BMJ
Antenatal prophylaxis with anti-D immunoglobulin | The BMJAntenatal prophylaxis with anti-D immunoglobulin | The BMJ
Adhesion molecule, immunoglobulin-like (IPR015169) | InterPro | EMBL-EBIAdhesion molecule, immunoglobulin-like (IPR015169) | InterPro | EMBL-EBI
Immunoglobulin D Deficiency: Background, Pathophysiology, EpidemiologyImmunoglobulin D Deficiency: Background, Pathophysiology, Epidemiology
Immunoglobulin A Deficiency | Johns Hopkins MedicineImmunoglobulin A Deficiency | Johns Hopkins Medicine
Immunoglobulin G - WikipediaImmunoglobulin G - Wikipedia
Immunoglobulin M - WikipediaImmunoglobulin M - Wikipedia
Intravenous Immunoglobulin (IVIG) | OncoLinkIntravenous Immunoglobulin (IVIG) | OncoLink
immunoglobulin facts, information, pictures | Encyclopedia.com articles about immunoglobulinimmunoglobulin facts, information, pictures | Encyclopedia.com articles about immunoglobulin
Immunoglobulin A Deficiency Medication: Vaccines, inactivated bacteriaImmunoglobulin A Deficiency Medication: Vaccines, inactivated bacteria
001776: Immunoglobulin G, Quantitative | LabCorp001776: Immunoglobulin G, Quantitative | LabCorp
002162: Immunoglobulin D, Quantitative | LabCorp002162: Immunoglobulin D, Quantitative | LabCorp
Immunoglobulin dictionary definition | immunoglobulin definedImmunoglobulin dictionary definition | immunoglobulin defined
Immunoglobulin A - WikipediaImmunoglobulin A - Wikipedia
Immunoglobulin G - definition of immunoglobulin G by The Free DictionaryImmunoglobulin G - definition of immunoglobulin G by The Free Dictionary
IGSF1 immunoglobulin superfamily member 1 [Homo sapiens (human)] - Gene - NCBIIGSF1 immunoglobulin superfamily member 1 [Homo sapiens (human)] - Gene - NCBI
What do elevated immunoglobulin levels mean? | Reference.comWhat do elevated immunoglobulin levels mean? | Reference.com
IV Immunoglobulin May Protect Against Alzheimers | Medpage TodayIV Immunoglobulin May Protect Against Alzheimer's | Medpage Today
Antenatal intravenous immunoglobulin in c... & related info | MendeleyAntenatal intravenous immunoglobulin in c... & related info | Mendeley
Intravenous Immunoglobulin (IVIg) Treatment May Benefit Some Children with Autism Spectrum DisorderIntravenous Immunoglobulin (IVIg) Treatment May Benefit Some Children with Autism Spectrum Disorder
What is an Immunoglobulin? (with pictures)What is an Immunoglobulin? (with pictures)
Intravenous immunoglobulin for Guillain-Barré syndromeIntravenous immunoglobulin for Guillain-Barré syndrome
Rh immunoglobulin - Medical Dictionary / Glossary | MedindiaRh immunoglobulin - Medical Dictionary / Glossary | Medindia
DailyMed - Search Results for Human ImmunoglobulinDailyMed - Search Results for Human Immunoglobulin
Intravenous immunoglobulin and the kidney--a two-edged sword. - PubMed - NCBIIntravenous immunoglobulin and the kidney--a two-edged sword. - PubMed - NCBI
Immunoglobulin E: Pathogenic Relevance in Immediate Contact Reactions | SpringerLinkImmunoglobulin E: Pathogenic Relevance in Immediate Contact Reactions | SpringerLink
A new member of the immunoglobulin superfamily--CTLA-4A new member of the immunoglobulin superfamily--CTLA-4
Rapid Global Characterization of Immunoglobulin G1 following Oxidative StressRapid Global Characterization of Immunoglobulin G1 following Oxidative Stress
Colostral Immunoglobulin Absorption in Intubated and Bottle-fed Calves - Aberra Molla - Google BooksColostral Immunoglobulin Absorption in Intubated and Bottle-fed Calves - Aberra Molla - Google Books
Immunoglobulin MImmunoglobulin M
Immunoglobulin AImmunoglobulin A
Intravenous Immunoglobulin (IVIG): uses & side-effects | PatientsLikeMeIntravenous Immunoglobulin (IVIG): uses & side-effects | PatientsLikeMe
Intravenous Immunoglobulin (IVIG): uses & side-effects | PatientsLikeMeIntravenous Immunoglobulin (IVIG): uses & side-effects | PatientsLikeMe
Immunoglobulin Products | Immune Deficiency FoundationImmunoglobulin Products | Immune Deficiency Foundation
Immunoglobulin A Nephropathy - definition of Immunoglobulin A Nephropathy by The Free DictionaryImmunoglobulin A Nephropathy - definition of Immunoglobulin A Nephropathy by The Free Dictionary
Cloning immunoglobulin variable domains for expression by the polymerase chain reaction | PNASCloning immunoglobulin variable domains for expression by the polymerase chain reaction | PNAS
Evaluation of commercially available anti-dengue virus immunoglobulin M testsEvaluation of commercially available anti-dengue virus immunoglobulin M tests
JCI - Immunoglobulin light chains generate proinflammatory and profibrotic kidney injuryJCI - Immunoglobulin light chains generate proinflammatory and profibrotic kidney injury
RCSB PDB - 1AR2: DISULFIDE-FREE IMMUNOGLOBULIN FRAGMENT Macromolecule Annotations PageRCSB PDB - 1AR2: DISULFIDE-FREE IMMUNOGLOBULIN FRAGMENT Macromolecule Annotations Page
RCSB PDB - Gene View - LILRB1 - leukocyte immunoglobulin like receptor B1RCSB PDB - Gene View - LILRB1 - leukocyte immunoglobulin like receptor B1
Serological Immunoglobulin-Free Light Chain Profile in Myasthenia Gravis PatientsSerological Immunoglobulin-Free Light Chain Profile in Myasthenia Gravis Patients
Global Immunoglobulin Market Size 2017 Industry Trend and Forecast... - QYResearchGlobal Immunoglobulin Market Size 2017 Industry Trend and Forecast... - QYResearch
Phys.org - immunoglobulinPhys.org - immunoglobulin
Immunoglobulin A and Gliadin IGA high - Celiac.comImmunoglobulin A and Gliadin IGA high - Celiac.com
Mouse Immunoglobulin Chromogenic Kit, WesternBreeze Chromogenic from InvitrogenMouse Immunoglobulin Chromogenic Kit, WesternBreeze Chromogenic from Invitrogen
Definition of Immunoglobulins | Chegg.comDefinition of Immunoglobulins | Chegg.com
immunoglobulin superfamily, member 10 Biomolecules | Biocompareimmunoglobulin superfamily, member 10 Biomolecules | Biocompare
Which dietary modifications are used in the treatment of immunoglobulin A (IgA) neuropathy?Which dietary modifications are used in the treatment of immunoglobulin A (IgA) neuropathy?
Anti-immunoglobulin stimulation of B lymphocytes activates src-related protein-tyrosine kinases. | PNASAnti-immunoglobulin stimulation of B lymphocytes activates src-related protein-tyrosine kinases. | PNAS
Primary Sclerosing Cholangitis Associated with Elevated Immunoglobulin-G4: A Preliminary StudyPrimary Sclerosing Cholangitis Associated with Elevated Immunoglobulin-G4: A Preliminary Study
Intravenous Immunoglobulin After Relapse in Vasculitis - Full Text View - ClinicalTrials.govIntravenous Immunoglobulin After Relapse in Vasculitis - Full Text View - ClinicalTrials.gov
Intravenous Immunoglobulin Therapy in Optic Neuritis - Full Text View - ClinicalTrials.govIntravenous Immunoglobulin Therapy in Optic Neuritis - Full Text View - ClinicalTrials.gov
Immunoglobulins devoid of light chains - Vrije, Universiteit BrusselImmunoglobulins devoid of light chains - Vrije, Universiteit Brussel
immunoglobulin | The ME Associationimmunoglobulin | The ME Association
Immunoglobulin - WellSpan Health LibraryImmunoglobulin - WellSpan Health Library
Antithymocyte immunoglobulin (rabbit) - DrugBankAntithymocyte immunoglobulin (rabbit) - DrugBank
Gut microbiota utilize immunoglobulin A for mucosal colonization | ScienceGut microbiota utilize immunoglobulin A for mucosal colonization | Science
Food Allergy: Immunoglobulin E-mediated | GreenMedInfo | DiseaseFood Allergy: Immunoglobulin E-mediated | GreenMedInfo | Disease
intravenous immunoglobulin | Journal of Neurology, Neurosurgery & Psychiatryintravenous immunoglobulin | Journal of Neurology, Neurosurgery & Psychiatry
False-Positive Results with a Commercially Available West Nile Virus Immunoglobulin M Assay --- United States, 2008False-Positive Results with a Commercially Available West Nile Virus Immunoglobulin M Assay --- United States, 2008
Immunoglobulins comprising predominantly a GlcNAc2Man3GlcNAc2 glycoform - Gerngross, Tillman U.Immunoglobulins comprising predominantly a GlcNAc2Man3GlcNAc2 glycoform - Gerngross, Tillman U.
Immunoglobulin E (IgE) ELISA KitImmunoglobulin E (IgE) ELISA Kit
immunoglobulin m - definition and meaningimmunoglobulin m - definition and meaning
Immunoglobulin, IgG | Health Testing CentersImmunoglobulin, IgG | Health Testing Centers
Immunoglobulin, IgM | Health Testing CentersImmunoglobulin, IgM | Health Testing Centers
Immunoglobulin Transport to the Neonate - Module 5: Mother & Neonate | CourseraImmunoglobulin Transport to the Neonate - Module 5: Mother & Neonate | Coursera
Maternal Immunoglobulin E and Childhood Leukemia | Cancer Epidemiology, Biomarkers & PreventionMaternal Immunoglobulin E and Childhood Leukemia | Cancer Epidemiology, Biomarkers & Prevention
Immunoglobulin: A Natural Way to Suppress Helicobacter pylori in HumansImmunoglobulin: A Natural Way to Suppress Helicobacter pylori in Humans
Bovine x mouse hybridomas that secrete bovine immunoglobulin G1 | ScienceBovine x mouse hybridomas that secrete bovine immunoglobulin G1 | Science
Immunoglobulins - DrugBankImmunoglobulins - DrugBank
Purified Immunoglobulins - Sera and Immunoglobulins | Sigma-AldrichPurified Immunoglobulins - Sera and Immunoglobulins | Sigma-Aldrich
Normal Sera - Sera and Immunoglobulins | Sigma-AldrichNormal Sera - Sera and Immunoglobulins | Sigma-Aldrich
Serum immunoglobulin profiles of septicemic versus healthy neonates.Serum immunoglobulin profiles of septicemic versus healthy neonates.
Octagam intravenous immunoglobulin solutions | Therapeutic Goods Administration (TGA)Octagam intravenous immunoglobulin solutions | Therapeutic Goods Administration (TGA)
CSF Immunoglobulin G (IgG) Index: MedlinePlus Medical TestCSF Immunoglobulin G (IgG) Index: MedlinePlus Medical Test
Global Intravenous Immunoglobulin (IVIg) Market Research Report 2017Global Intravenous Immunoglobulin (IVIg) Market Research Report 2017
THE IMMUNOGLOBULINS OF MICE | JEMTHE IMMUNOGLOBULINS OF MICE | JEM
WikiGenes - Genes, ImmunoglobulinWikiGenes - Genes, Immunoglobulin
Immunoglobulin E - wikidocImmunoglobulin E - wikidoc
Immunoglobulin D - wikidocImmunoglobulin D - wikidoc
Interactions between Norethindrone Acetate-Ethinyl Estradiol Oral and estrogens-selected-human-immunoglobulinsInteractions between Norethindrone Acetate-Ethinyl Estradiol Oral and estrogens-selected-human-immunoglobulins
Biomolecules | Free Full-Text | The Immunoglobulins of Cold-Blooded VertebratesBiomolecules | Free Full-Text | The Immunoglobulins of Cold-Blooded Vertebrates
Browsing Publications by Subject Immunoglobulin MBrowsing Publications by Subject "Immunoglobulin M"
AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesAnthropology, Education, Sociology and Social PhenomenaTechnology, Industry, AgricultureInformation ScienceHealth Care
Immunoglobulins, IntravenousImmunization, PassiveEncyclopedias as TopicReceptors, IgGImmunoglobulinsImmunoglobulin GActinobacillus suisMice, HairlessImmunoglobulin AImmunoglobulin MPemphigoid, Benign Mucous MembraneSalivaImmunoglobulin EAllergensHypersensitivitySkin TestsHypersensitivity, ImmediateDesensitization, ImmunologicAsthmaEncephalomalaciaIgA DeficiencyDysgammaglobulinemiaAgammaglobulinemiaIgG DeficiencyImmunologic Deficiency SyndromesDictionaries, MedicalMeaslesMeasles virusMeasles VaccineDictionaries as TopicCrowdsourcingTerminology as TopicRho(D) Immune GlobulinElectronic MailRh IsoimmunizationErythroblastosis, FetalRh-Hr Blood-Group SystemFetomaternal TransfusionAbortion, ThreatenedCommon Variable ImmunodeficiencyImmunoglobulin Heavy ChainsReceptors, Polymeric ImmunoglobulinSecretory ComponentImmunoglobulin A, SecretoryEpithelial CellsPlasma CellsGenes, ImmunoglobulinDrug LabelingDrug RepositioningProduct LabelingUnited States Food and Drug AdministrationPrescription DrugsSearch Engine
AntibodiesSerumSpecificityIsotypeIgG4IgG2HumanTissueIVIGProteinsSuperfamily memberMonoclonalIsotypesLight chainsNephropathyTherapyLevel of immunoglobulinEnzyme-linkeSerum immunoglobulinsQuantitativeHttpsMouse immunoglobulinNormal immunoglobulinReplacement immunoglobulinChainsGeneDeficiencyRabiesMiceAntigensType of antibodySubstancesIndicationsAutoimmune2017GlycoproteinsImmune systemComplement systemHumanAntigen specificBloodSecretionsFLCsAntibody responsesMeaslesDiseasesEfficacySecretory component
Antibodies1
Serum2
Specificity1
Isotype1
IgG41
IgG21
Human1
Tissue1
IVIG12
Proteins5
Superfamily member1
Monoclonal3
  • Because of the less-than-robust response to therapy and impact on choice of optimal chemotherapy and prognosis, chronic kidney disease has drawn attention in the treatment of multiple myeloma, a malignant hematologic disorder that can produce significant amounts of monoclonal immunoglobulin free light chains (FLCs). (jci.org)
  • To the extent that the experiments reflect the human condition, these studies offer insights into the pathogenesis of progressive kidney failure in the setting of lymphoproliferative disorders, such as multiple myeloma, that feature increased circulating levels of monoclonal immunoglobulin fragments that require metabolism by the kidney. (jci.org)
  • A monoclonal anti-immunoglobulin E antibody used in the treatment of severe asthma and chronic idiopathic urticaria. (drugbank.ca)
Isotypes1
Light chains4
Nephropathy5
Therapy9
  • Human immunoglobulin therapy first occurred in the 1930s and a formulation for injection into a vein was approved for medical use in the United States in 1981. (wikipedia.org)
  • Immunoglobulin therapy is also used for a number of other conditions, including in many autoimmune disorders such as dermatomyositis in an attempt to decrease the severity of symptoms. (wikipedia.org)
  • Immunoglobulin therapy is also used in some treatment protocols for secondary immunodeficiencies such as human immunodeficiency virus (HIV), some autoimmune disorders (such as immune thrombocytopenia and Kawasaki disease ), some neurological diseases ( multifocal motor neuropathy , stiff person syndrome , multiple sclerosis and myasthenia gravis ) some acute infections and some complications of organ transplantation. (wikipedia.org)
  • Immunoglobulin therapy is especially useful in some acute infection cases such as pediatric HIV infection and is also considered the standard of treatment for some autoimmune disorders such as Guillain-Barré syndrome . (wikipedia.org)
  • Different national bodies and medical associations have established varying standards for the use of immunoglobulin therapy. (wikipedia.org)
  • The National Advisory Committee on Blood and Blood Products of Canada (NAC) and Canadian Blood Services have also developed their own separate set of guidelines for the appropriate use of immunoglobulin therapy, which strongly support the use of immunoglobulin therapy in primary immunodeficiencies and some complications of HIV, while remaining silent on the issues of sepsis, multiple sclerosis, and chronic fatigue syndrome. (wikipedia.org)
  • In November 2011, the IDF Medical Advisory Committee wrote a resolution regarding formulary changes that limit a physician's ability to determine the most appropriate immunoglobulin replacement therapy. (primaryimmune.org)
  • Don't recommend replacement immunoglobulin therapy for recurrent infections unless impaired antibody responses to vaccines are demonstrated. (choosingwisely.org)
  • Measurement of IgG subclasses is not routinely useful in determining the need for immunoglobulin therapy. (choosingwisely.org)
Level of immunoglobulin1
Enzyme-linke2
  • Evaluation of Immunoglobulin A-capture Enzyme-linked Immunosorbent Assay for Serodiagnosis of Dengue Virus Infection. (who.int)
  • In September 2008, CDC, the Food and Drug Administration (FDA), and state health departments began a nationwide investigation into an increase in false-positive test results obtained with a commercially available West Nile virus (WNV) immunoglobulin M (IgM) capture enzyme-linked immunosorbent assay (ELISA). (cdc.gov)
Serum immunoglobulins2
Quantitative2
Https1
Mouse immunoglobulin1
  • We have designed a set of oligonucleotide primers to amplify the cDNA of mouse immunoglobulin heavy and light chain variable domains by the polymerase chain reaction. (pnas.org)
Normal immunoglobulin2
  • The V domains of normal immunoglobulin are highly heterogeneous, reflecting their role in protecting against the great variety of infectious microbes, and this heterogeneity impeded detailed structural analysis of IgM. (wikipedia.org)
  • Normal immunoglobulin E, or IgE, levels in children are 10 international units per milliliter for 1-year-olds. (reference.com)
Replacement immunoglobulin1
  • Restricting access of subscribers to only one or two product/formulations of replacement immunoglobulin regardless of the particular product the patient may currently be receiving poses an unjustified safety risk for patients. (primaryimmune.org)
Chains2
Gene2
Deficiency6
Rabies10
Mice1
  • We found that a regulatory system in the prominent human commensal Bacteroides fragilis modulates its surface architecture to invite binding of immunoglobulin A (IgA) in mice. (sciencemag.org)
Antigens5
Type of antibody1
Substances1
Indications1
  • Overall, 2% of patients who had received IV immunoglobulin for various indications were affected, compared with 4.1% of controls who had not received the treatment ( P =0.002), Howard Fillit, MD, of Mount Sinai School of Medicine in New York, and colleagues reported in the July 21 issue of Neurology . (medpagetoday.com)
Autoimmune2
20172
Glycoproteins1
Immune system2
  • Binding of the immunoglobulins to a microbe can have immediate effects such as blocking invasion and it can mobilize other components of the immune system to destroy or otherwise inactivate the microbes, thereby providing protection against infectious diseases. (wikipedia.org)
  • Allergic (extrinsic) asthma is associated with immunoglobulin E (IgE)-an antibody generated by the immune system, in this case, in response to a normally harmless substance. (verywellhealth.com)
Complement system2
Human6
Antigen specific1
Blood14
Secretions4
FLCs1
  • The present study demonstrated that during the process of metabolism of immunoglobulin FLCs, ROS activated the STAT1 pathway in proximal tubule epithelium. (jci.org)
Antibody responses1
Measles2
  • These conditions include primary immunodeficiency , immune thrombocytopenic purpura , chronic inflammatory demyelinating polyneuropathy , Kawasaki disease , certain cases of HIV/AIDS and measles , Guillain-Barré syndrome , and certain other infections when a more specific immunoglobulin is not available. (wikipedia.org)
  • You may be given an immunoglobulin if you are exposed to certain infectious diseases, such as hepatitis A , rubella , or measles. (wellspan.org)
Diseases3
  • The Chinese company added that the bovine immunoglobulin G (IgG) kits helps to prevent and treat blue ear disease, respiratory pneumonia, pseudorabies, swine fever and foot and mouth disease, which are common diseases affecting pig in the farming industry. (thefreedictionary.com)
  • IV immunoglobulin has been used safely for more than 20 years to treat other diseases but is thought to have an indirect effect on Alzheimer's disease by targeting beta-amyloid," Dr. Fillit said. (medpagetoday.com)
  • And if I remember correctly these diseases occur with low immunoglobulin counts so the immunoglobulin being administered via IV may be to increase the levels as opposed to replenish the levels. (wisegeek.com)
Efficacy1
Secretory component1
PLOS ONE: Microbiota and Metabolome Associated with Immunoglobulin A Nephropathy (IgAN)
PLOS ONE: Microbiota and Metabolome Associated with Immunoglobulin A Nephropathy (IgAN) (journals.plos.org)
Bovine FcRn-Mediated Human Immunoglobulin G Transfer across the Milk-Blood Barrier in Transgenic Mice
Bovine FcRn-Mediated Human Immunoglobulin G Transfer across the Milk-Blood Barrier in Transgenic Mice (journals.plos.org)
Loci Associated with N-Glycosylation of Human Immunoglobulin G Show Pleiotropy with Autoimmune Diseases and Haematological...
Loci Associated with N-Glycosylation of Human Immunoglobulin G Show Pleiotropy with Autoimmune Diseases and Haematological... (journals.plos.org)
Best Labs and Diagnostic Centers for Immunoglobulin M in Thane | 1mg
Best Labs and Diagnostic Centers for Immunoglobulin M in Thane | 1mg (1mg.com)
Multiple Myeloma | Encyclopedia.com
Multiple Myeloma | Encyclopedia.com (encyclopedia.com)
Structure of immunoglobulin | teaguedesigninc
Structure of immunoglobulin | teaguedesigninc (teaguedesigninc.com)
Supportive Treatments for Patients With Multiple Myeloma
Supportive Treatments for Patients With Multiple Myeloma (cancer.org)
The Immunoglobulin a System | SpringerLink
The Immunoglobulin a System | SpringerLink (link.springer.com)
Plus it
Plus it (bmj.com)
Coccidioidomycosis and Valley Fever Workup: Approach Considerations, Serologic Studies, Cultures
Coccidioidomycosis and Valley Fever Workup: Approach Considerations, Serologic Studies, Cultures (emedicine.medscape.com)
Chronic Lymphocytic Leukemia (CLL): Symptoms and More
Chronic Lymphocytic Leukemia (CLL): Symptoms and More (healthline.com)
Severe Acute Respiratory Syndrome (SARS) Treatment & Management: Approach Considerations, Pharmacotherapy, Vaccine
Severe Acute Respiratory Syndrome (SARS) Treatment & Management: Approach Considerations, Pharmacotherapy, Vaccine (emedicine.medscape.com)
WHO Model List of Essential Medicines - Wikipedia
WHO Model List of Essential Medicines - Wikipedia (en.wikipedia.org)
Plus it
Plus it (bmj.com)
Blood Test: Immunoglobulin E (IgE) (for Parents) - Inova Fairfax Hospital
Blood Test: Immunoglobulin E (IgE) (for Parents) - Inova Fairfax Hospital (kidshealth.org)
Blood Test: Immunoglobulin A (IgA)
Blood Test: Immunoglobulin A (IgA) (kidshealth.org)
Emergent Management of Necrotizing Soft-Tissue Infections: Overview, Pathophysiology, Epidemiology and Microbiology
Emergent Management of Necrotizing Soft-Tissue Infections: Overview, Pathophysiology, Epidemiology and Microbiology (emedicine.medscape.com)
Antibody Immunoglobulin Diversity
Antibody Immunoglobulin Diversity (news-medical.net)
Bronchiectasis Workup: Approach Considerations, Sputum Analysis, CBC Count
Bronchiectasis Workup: Approach Considerations, Sputum Analysis, CBC Count (emedicine.medscape.com)
Dermatomyositis: Causes, Symptoms, and Treatment
Dermatomyositis: Causes, Symptoms, and Treatment (healthline.com)
Immunoglobulin-Related Amyloidosis: Practice Essentials, Pathophysiology, Etiology
Immunoglobulin-Related Amyloidosis: Practice Essentials, Pathophysiology, Etiology (emedicine.medscape.com)
What is immunoglobulin A (IgA) nephropathy?
What is immunoglobulin A (IgA) nephropathy? (medscape.com)
Platelet Disorders: Overview of Platelet Disorders, Pathophysiology of Platelet Disorders, Autoimmune Thrombocytopenias
Platelet Disorders: Overview of Platelet Disorders, Pathophysiology of Platelet Disorders, Autoimmune Thrombocytopenias (emedicine.medscape.com)
Immunoglobulin A Deficiency Medication: Vaccines, inactivated bacteria
Immunoglobulin A Deficiency Medication: Vaccines, inactivated bacteria (emedicine.medscape.com)
Immunoglobulin News, Research
Immunoglobulin News, Research (news-medical.net)
Kidney Transplant Program - Massachusetts General Hospital, Boston, MA
Kidney Transplant Program - Massachusetts General Hospital, Boston, MA (massgeneral.org)
What to Expect with HYQVIA | Subcutaneous Immunoglobulin Infusion
What to Expect with HYQVIA | Subcutaneous Immunoglobulin Infusion (hyqvia.com)
Parasitic listahan ng halaman - Immunoglobulin g on parasito
Parasitic listahan ng halaman - Immunoglobulin g on parasito (keramika-kubani.ru)
LLS Search Results | Leukemia and Lymphoma Society