An immunoglobulin associated with MAST CELLS. Overexpression has been associated with allergic hypersensitivity (HYPERSENSITIVITY, IMMEDIATE).
The major immunoglobulin isotype class in normal human serum. There are several isotype subclasses of IgG, for example, IgG1, IgG2A, and IgG2B.
Multi-subunit proteins which function in IMMUNITY. They are produced by B LYMPHOCYTES from the IMMUNOGLOBULIN GENES. They are comprised of two heavy (IMMUNOGLOBULIN HEAVY CHAINS) and two light chains (IMMUNOGLOBULIN LIGHT CHAINS) with additional ancillary polypeptide chains depending on their isoforms. The variety of isoforms include monomeric or polymeric forms, and transmembrane forms (B-CELL ANTIGEN RECEPTORS) or secreted forms (ANTIBODIES). They are divided by the amino acid sequence of their heavy chains into five classes (IMMUNOGLOBULIN A; IMMUNOGLOBULIN D; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M) and various subclasses.
A class of immunoglobulin bearing mu chains (IMMUNOGLOBULIN MU-CHAINS). IgM can fix COMPLEMENT. The name comes from its high molecular weight and originally being called a macroglobulin.
Represents 15-20% of the human serum immunoglobulins, mostly as the 4-chain polymer in humans or dimer in other mammals. Secretory IgA (IMMUNOGLOBULIN A, SECRETORY) is the main immunoglobulin in secretions.
Specific molecular sites on the surface of B- and T-lymphocytes which combine with IgEs. Two subclasses exist: low affinity receptors (Fc epsilon RII) and high affinity receptors (Fc epsilon RI).
The largest of polypeptide chains comprising immunoglobulins. They contain 450 to 600 amino acid residues per chain, and have molecular weights of 51-72 kDa.
Antigen-type substances that produce immediate hypersensitivity (HYPERSENSITIVITY, IMMEDIATE).
Immunoglobulin preparations used in intravenous infusion, containing primarily IMMUNOGLOBULIN G. They are used to treat a variety of diseases associated with decreased or abnormal immunoglobulin levels including pediatric AIDS; primary HYPERGAMMAGLOBULINEMIA; SCID; CYTOMEGALOVIRUS infections in transplant recipients, LYMPHOCYTIC LEUKEMIA, CHRONIC; Kawasaki syndrome, infection in neonates, and IDIOPATHIC THROMBOCYTOPENIC PURPURA.
Genes encoding the different subunits of the IMMUNOGLOBULINS, for example the IMMUNOGLOBULIN LIGHT CHAIN GENES and the IMMUNOGLOBULIN HEAVY CHAIN GENES. The heavy and light immunoglobulin genes are present as gene segments in the germline cells. The completed genes are created when the segments are shuffled and assembled (B-LYMPHOCYTE GENE REARRANGEMENT) during B-LYMPHOCYTE maturation. The gene segments of the human light and heavy chain germline genes are symbolized V (variable), J (joining) and C (constant). The heavy chain germline genes have an additional segment D (diversity).
Altered reactivity to an antigen, which can result in pathologic reactions upon subsequent exposure to that particular antigen.
Polypeptide chains, consisting of 211 to 217 amino acid residues and having a molecular weight of approximately 22 kDa. There are two major types of light chains, kappa and lambda. Two Ig light chains and two Ig heavy chains (IMMUNOGLOBULIN HEAVY CHAINS) make one immunoglobulin molecule.
Hypersensitivity reactions which occur within minutes of exposure to challenging antigen due to the release of histamine which follows the antigen-antibody reaction and causes smooth muscle contraction and increased vascular permeability.
Granular leukocytes characterized by a relatively pale-staining, lobate nucleus and cytoplasm containing coarse dark-staining granules of variable size and stainable by basic dyes.
Epicutaneous or intradermal application of a sensitizer for demonstration of either delayed or immediate hypersensitivity. Used in diagnosis of hypersensitivity or as a test for cellular immunity.
One of the types of light chains of the immunoglobulins with a molecular weight of approximately 22 kDa.
Gastrointestinal disturbances, skin eruptions, or shock due to allergic reactions to allergens in food.
The classes of immunoglobulins found in any species of animal. In man there are nine classes that migrate in five different groups in electrophoresis; they each consist of two light and two heavy protein chains, and each group has distinguishing structural and functional properties.
Granulated cells that are found in almost all tissues, most abundantly in the skin and the gastrointestinal tract. Like the BASOPHILS, mast cells contain large amounts of HISTAMINE and HEPARIN. Unlike basophils, mast cells normally remain in the tissues and do not circulate in the blood. Mast cells, derived from the bone marrow stem cells, are regulated by the STEM CELL FACTOR.
The principle immunoglobulin in exocrine secretions such as milk, respiratory and intestinal mucin, saliva and tears. The complete molecule (around 400 kD) is composed of two four-chain units of IMMUNOGLOBULIN A, one SECRETORY COMPONENT and one J chain (IMMUNOGLOBULIN J-CHAINS).
That region of the immunoglobulin molecule that varies in its amino acid sequence and composition, and comprises the binding site for a specific antigen. It is located at the N-terminus of the Fab fragment of the immunoglobulin. It includes hypervariable regions (COMPLEMENTARITY DETERMINING REGIONS) and framework regions.
Lymphoid cells concerned with humoral immunity. They are short-lived cells resembling bursa-derived lymphocytes of birds in their production of immunoglobulin upon appropriate stimulation.
Crystallizable fragments composed of the carboxy-terminal halves of both IMMUNOGLOBULIN HEAVY CHAINS linked to each other by disulfide bonds. Fc fragments contain the carboxy-terminal parts of the heavy chain constant regions that are responsible for the effector functions of an immunoglobulin (COMPLEMENT fixation, binding to the cell membrane via FC RECEPTORS, and placental transport). This fragment can be obtained by digestion of immunoglobulins with the proteolytic enzyme PAPAIN.
The class of heavy chains found in IMMUNOGLOBULIN M. They have a molecular weight of approximately 72 kDa and they contain about 57 amino acid residues arranged in five domains and have more oligosaccharide branches and a higher carbohydrate content than the heavy chains of IMMUNOGLOBULIN G.
An in vitro allergen radioimmunoassay in which allergens are coupled to an immunosorbent. The coupled allergens bind the IgE in the sera of patients which in turn binds radioisotope-labeled anti-IMMUNOGLOBULIN E antibodies.
Gene rearrangement of the B-lymphocyte which results in a substitution in the type of heavy-chain constant region that is expressed. This allows the effector response to change while the antigen binding specificity (variable region) remains the same. The majority of class switching occurs by a DNA recombination event but it also can take place at the level of RNA processing.
One of the types of light chain subunits of the immunoglobulins with a molecular weight of approximately 22 kDa.
A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).
Antibodies which react with the individual structural determinants (idiotopes) on the variable region of other antibodies.
An immunoglobulin which accounts for less than 1% of plasma immunoglobulin. It is found on the membrane of many circulating B LYMPHOCYTES.
The secretion of histamine from mast cell and basophil granules by exocytosis. This can be initiated by a number of factors, all of which involve binding of IgE, cross-linked by antigen, to the mast cell or basophil's Fc receptors. Once released, histamine binds to a number of different target cell receptors and exerts a wide variety of effects.
A soluble factor produced by activated T-LYMPHOCYTES that induces the expression of MHC CLASS II GENES and FC RECEPTORS on B-LYMPHOCYTES and causes their proliferation and differentiation. It also acts on T-lymphocytes, MAST CELLS, and several other hematopoietic lineage cells.
The domains of the immunoglobulin molecules that are invariable in their amino acid sequence within any class or subclass of immunoglobulin. They confer biological as well as structural functions to immunoglobulins. One each on both the light chains and the heavy chains comprises the C-terminus half of the IMMUNOGLOBULIN FAB FRAGMENT and two or three of them make up the rest of the heavy chains (all of the IMMUNOGLOBULIN FC FRAGMENT)
The class of heavy chains found in IMMUNOGLOBULIN E. They have a molecular weight of approximately 72 kDa and they contain about 550 amino acid residues arranged in five domains and about three times more carbohydrate than the heavy chains of IMMUNOGLOBULIN A; IMMUNOGLOBULIN D; and IMMUNOGLOBULIN G.
A chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. It is manifested by lichenification, excoriation, and crusting, mainly on the flexural surfaces of the elbow and knee. In infants it is known as infantile eczema.
An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.
Molecules found on the surface of some, but not all, B-lymphocytes, T-lymphocytes, and macrophages, which recognize and combine with the Fc (crystallizable) portion of immunoglobulin molecules.
Substances found in PLANTS that have antigenic activity.
An acute hypersensitivity reaction due to exposure to a previously encountered ANTIGEN. The reaction may include rapidly progressing URTICARIA, respiratory distress, vascular collapse, systemic SHOCK, and death.
Allergic reaction to products containing processed natural rubber latex such as rubber gloves, condoms, catheters, dental dams, balloons, and sporting equipment. Both T-cell mediated (HYPERSENSITIVITY, DELAYED) and IgE antibody-mediated (HYPERSENSITIVITY, IMMEDIATE) allergic responses are possible. Delayed hypersensitivity results from exposure to antioxidants present in the rubber; immediate hypersensitivity results from exposure to a latex protein.
The property of antibodies which enables them to react with some ANTIGENIC DETERMINANTS and not with others. Specificity is dependent on chemical composition, physical forces, and molecular structure at the binding site.
Heavy chains of IMMUNOGLOBULIN G having a molecular weight of approximately 51 kDa. They contain about 450 amino acid residues arranged in four domains and an oligosaccharide component covalently bound to the Fc fragment constant region. The gamma heavy chain subclasses (for example, gamma 1, gamma 2a, and gamma 2b) of the IMMUNOGLOBULIN G isotype subclasses (IgG1, IgG2A, and IgG2B) resemble each other more closely than the heavy chains of the other IMMUNOGLOBULIN ISOTYPES.
A rare acute myeloid leukemia in which the primary differentiation is to BASOPHILS. It is characterized by an extreme increase of immature basophilic granulated cells in the bone marrow and blood. Mature basophils are usually sparse.
Univalent antigen-binding fragments composed of one entire IMMUNOGLOBULIN LIGHT CHAIN and the amino terminal end of one of the IMMUNOGLOBULIN HEAVY CHAINS from the hinge region, linked to each other by disulfide bonds. Fab contains the IMMUNOGLOBULIN VARIABLE REGIONS, which are part of the antigen-binding site, and the first IMMUNOGLOBULIN CONSTANT REGIONS. This fragment can be obtained by digestion of immunoglobulins with the proteolytic enzyme PAPAIN.
Family of MITES, in the superfamily Acaroidea, order Astigmata. They are frequently found in cereal-based foodstuffs including GRAIN and FLOUR.
Inflammation of the mucous membrane of the nose similar to that found in hay fever except that symptoms persist throughout the year. The causes are usually air-borne allergens, particularly dusts, feathers, molds, animal fur, etc.
A 15 kD "joining" peptide that forms one of the linkages between monomers of IMMUNOGLOBULIN A or IMMUNOGLOBULIN M in the formation of polymeric immunoglobulins. There is one J chain per one IgA dimer or one IgM pentamer. It is also involved in binding the polymeric immunoglobulins to POLYMERIC IMMUNOGLOBULIN RECEPTOR which is necessary for their transcytosis to the lumen. It is distinguished from the IMMUNOGLOBULIN JOINING REGION which is part of the IMMUNOGLOBULIN VARIABLE REGION of the immunoglobulin light and heavy chains.
Partial immunoglobulin molecules resulting from selective cleavage by proteolytic enzymes or generated through PROTEIN ENGINEERING techniques.
Allergic rhinitis that occurs at the same time every year. It is characterized by acute CONJUNCTIVITIS with lacrimation and ITCHING, and regarded as an allergic condition triggered by specific ALLERGENS.
Allelic variants of the immunoglobulin light chains (IMMUNOGLOBULIN LIGHT CHAINS) or heavy chains (IMMUNOGLOBULIN HEAVY CHAINS) encoded by ALLELES of IMMUNOGLOBULIN GENES.
An evanescent cutaneous reaction occurring when antibody is injected into a local area on the skin and antigen is subsequently injected intravenously along with a dye. The dye makes the rapidly occurring capillary dilatation and increased vascular permeability readily visible by leakage into the reaction site. PCA is a sensitive reaction for detecting very small quantities of antibodies and is also a method for studying the mechanisms of immediate hypersensitivity.
Specialized Fc receptors (RECEPTORS, FC) for polymeric immunoglobulins, which mediate transcytosis of polymeric IMMUNOGLOBULIN A and IMMUNOGLOBULIN M into external secretions. They are found on the surfaces of epithelial cells and hepatocytes. After binding to IMMUNOGLOBULIN A, the receptor-ligand complex undergoes endocytosis, transport by vesicle, and secretion into the lumen by exocytosis. Before release, the part of the receptor (SECRETORY COMPONENT) that is bound to IMMUNOGLOBULIN A is proteolytically cleaved from its transmembrane tail. (From Rosen et al., The Dictionary of Immunology, 1989)
An albumin obtained from the white of eggs. It is a member of the serpin superfamily.
Allergic reaction to milk (usually cow's milk) or milk products. MILK HYPERSENSITIVITY should be differentiated from LACTOSE INTOLERANCE, an intolerance to milk as a result of congenital deficiency of lactase.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
A segment of the immunoglobulin heavy chains, encoded by the IMMUNOGLOBULIN HEAVY CHAIN GENES in the J segment where, during the maturation of B-LYMPHOCYTES; the gene segment for the variable region upstream is joined to a constant region gene segment downstream. The exact position of joining of the two gene segments is variable and contributes to ANTIBODY DIVERSITY. It is distinguished from the IMMUNOGLOBULIN J CHAINS; a separate polypeptide that serves as a linkage piece in polymeric IGA or IGM.
Immunoglobulins produced in a response to BACTERIAL ANTIGENS.
Membrane antigens associated with maturation stages of B-lymphocytes, often expressed in tumors of B-cell origin.
Tendency of the smooth muscle of the tracheobronchial tree to contract more intensely in response to a given stimulus than it does in the response seen in normal individuals. This condition is present in virtually all symptomatic patients with asthma. The most prominent manifestation of this smooth muscle contraction is a decrease in airway caliber that can be readily measured in the pulmonary function laboratory.
A form of hypersensitivity affecting the respiratory tract. It includes ASTHMA and RHINITIS, ALLERGIC, SEASONAL.
An excess of GAMMA-GLOBULINS in the serum due to chronic infections or PARAPROTEINEMIAS.
The production of ANTIBODIES by proliferating and differentiated B-LYMPHOCYTES under stimulation by ANTIGENS.
Subset of helper-inducer T-lymphocytes which synthesize and secrete the interleukins IL-4, IL-5, IL-6, and IL-10. These cytokines influence B-cell development and antibody production as well as augmenting humoral responses.
Any arthropod of the subclass ACARI except the TICKS. They are minute animals related to the spiders, usually having transparent or semitransparent bodies. They may be parasitic on humans and domestic animals, producing various irritations of the skin (MITE INFESTATIONS). Many mite species are important to human and veterinary medicine as both parasite and vector. Mites also infest plants.
Immunoglobulins produced in a response to HELMINTH ANTIGENS.
Antigens from the house dust mites (DERMATOPHAGOIDES), mainly D. farinae and D. pteronyssinus. They are proteins, found in mite feces or mite extracts, that can cause ASTHMA and other allergic diseases such as perennial rhinitis (RHINITIS, ALLERGIC, PERENNIAL) and atopic dermatitis (DERMATITIS, ATOPIC). More than 11 groups of Dermatophagoides ALLERGENS have been defined. Group I allergens, such as Der f I and Der p I from the above two species, are among the strongest mite immunogens in humans.
Allergic reaction to eggs that is triggered by the immune system.
Antibodies produced by a single clone of cells.
Allergic reaction to peanuts that is triggered by the immune system.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
The process of losing secretory granules (SECRETORY VESICLES). This occurs, for example, in mast cells, basophils, neutrophils, eosinophils, and platelets when secretory products are released from the granules by EXOCYTOSIS.
The fertilizing element of plants that contains the male GAMETOPHYTES.
Agents that are used to treat allergic reactions. Most of these drugs act by preventing the release of inflammatory mediators or inhibiting the actions of released mediators on their target cells. (From AMA Drug Evaluations Annual, 1994, p475)
Skin tests in which the sensitizer is injected.
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
IMMUNOGLOBULINS on the surface of B-LYMPHOCYTES. Their MESSENGER RNA contains an EXON with a membrane spanning sequence, producing immunoglobulins in the form of type I transmembrane proteins as opposed to secreted immunoglobulins (ANTIBODIES) which do not contain the membrane spanning segment.
Serological reactions in which an antiserum against one antigen reacts with a non-identical but closely related antigen.
Immunoglobulins produced in a response to FUNGAL ANTIGENS.
Abnormal immunoglobulins characteristic of MULTIPLE MYELOMA.
An encapsulated lymphatic organ through which venous blood filters.
Deliberate stimulation of the host's immune response. ACTIVE IMMUNIZATION involves administration of ANTIGENS or IMMUNOLOGIC ADJUVANTS. PASSIVE IMMUNIZATION involves administration of IMMUNE SERA or LYMPHOCYTES or their extracts (e.g., transfer factor, immune RNA) or transplantation of immunocompetent cell producing tissue (thymus or bone marrow).
Substances that are recognized by the immune system and induce an immune reaction.
Genes and gene segments encoding the IMMUNOGLOBULIN HEAVY CHAINS. Gene segments of the heavy chain genes are symbolized V (variable), D (diversity), J (joining), and C (constant).
A programmed mutation process whereby changes are introduced to the nucleotide sequence of immunoglobulin gene DNA during development.
Any discrete, presumably solitary, mass of neoplastic PLASMA CELLS either in BONE MARROW or various extramedullary sites.
Any part or derivative of a helminth that elicits an immune reaction. The most commonly seen helminth antigens are those of the schistosomes.
A cytokine that promotes differentiation and activation of EOSINOPHILS. It also triggers activated B-LYMPHOCYTES to differentiate into IMMUNOGLOBULIN-secreting cells.
The class of heavy chains found in IMMUNOGLOBULIN D. They have a molecular weight of approximately 64 kDa and they contain about 500 amino acid residues arranged in four domains and an oligosaccharide component covalently bound to the Fc fragment constant region.
A family of CRUSTACEA, order DECAPODA, comprising the pandalid shrimp. They are protandric hermaphrodites and can breed in both male and female stages. Many species are commercially harvested in the Pacific Northwest.
A site located in the INTRONS at the 5' end of each constant region segment of a immunoglobulin heavy-chain gene where recombination (or rearrangement) occur during IMMUNOGLOBULIN CLASS SWITCHING. Ig switch regions are found on genes encoding all five classes (IMMUNOGLOBULIN ISOTYPES) of IMMUNOGLOBULIN HEAVY CHAINS.
Immunosuppression by the administration of increasing doses of antigen. Though the exact mechanism is not clear, the therapy results in an increase in serum levels of allergen-specific IMMUNOGLOBULIN G, suppression of specific IgE, and an increase in suppressor T-cell activity.
Primary immunodeficiency syndrome characterized by recurrent infections and hyperimmunoglobulinemia E. Most cases are sporadic. Of the rare familial forms, the dominantly inherited subtype has additional connective tissue, dental and skeletal involvement that the recessive type does not share.
Immunologically mediated adverse reactions to medicinal substances used legally or illegally.
The class of heavy chains found in IMMUNOGLOBULIN A. They have a molecular weight of approximately 58 kDa and contain about 470 amino acid residues arranged in four domains and an oligosaccharide component bound covalently to their Fc fragment constant region.
Hypersensitivity reaction (ALLERGIC REACTION) to fungus ASPERGILLUS in an individual with long-standing BRONCHIAL ASTHMA. It is characterized by pulmonary infiltrates, EOSINOPHILIA, elevated serum IMMUNOGLOBULIN E, and skin reactivity to Aspergillus antigen.
Unique genetically-controlled determinants present on ANTIBODIES whose specificity is limited to a single group of proteins (e.g., another antibody molecule or an individual myeloma protein). The idiotype appears to represent the antigenicity of the antigen-binding site of the antibody and to be genetically codetermined with it. The idiotypic determinants have been precisely located to the IMMUNOGLOBULIN VARIABLE REGION of both immunoglobin polypeptide chains.
Sites on an antigen that interact with specific antibodies.
Established cell cultures that have the potential to propagate indefinitely.
Family of house dust mites, in the superfamily Analgoidea, order Astigmata. They include the genera Dermatophagoides and Euroglyphus.
A specific immune response elicited by a specific dose of an immunologically active substance or cell in an organism, tissue, or cell.
Radioimmunoassay of proteins using antibody coupled to an immunosorbent.
A plant genus of the family FABACEAE that is a source of prosopis gum.
Serum globulins that migrate to the gamma region (most positively charged) upon ELECTROPHORESIS. At one time, gamma-globulins came to be used as a synonym for immunoglobulins since most immunoglobulins are gamma globulins and conversely most gamma globulins are immunoglobulins. But since some immunoglobulins exhibit an alpha or beta electrophoretic mobility, that usage is in decline.
Immunoglobulins produced in response to VIRAL ANTIGENS.
Granular leukocytes with a nucleus that usually has two lobes connected by a slender thread of chromatin, and cytoplasm containing coarse, round granules that are uniform in size and stainable by eosin.
Phthalic acid anhydrides. Can be substituted on any carbon atom. Used extensively in industry and as a reagent in the acylation of amino- and hydroxyl groups.
Immunoglobulins produced in a response to PROTOZOAN ANTIGENS.
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
Abnormal increase of EOSINOPHILS in the blood, tissues or organs.
Leukemia induced experimentally in animals by exposure to leukemogenic agents, such as VIRUSES; RADIATION; or by TRANSPLANTATION of leukemic tissues.
The extracellular moiety of the POLYMERIC IMMUNOGLOBULIN RECEPTOR found alone or complexed with IGA or IGM, in a variety of external secretions (tears, bile, colostrum.) Secretory component is derived by proteolytic cleavage of the receptor during transcytosis. When immunoglobulins IgA and IgM are bound to the receptor, during their transcytosis secretory component becomes covalently attached to them generating SECRETORY IMMUNOGLOBULIN A or secretory IMMUNOGLOBULIN M.
A cytokine synthesized by T-LYMPHOCYTES that produces proliferation, immunoglobulin isotype switching, and immunoglobulin production by immature B-LYMPHOCYTES. It appears to play a role in regulating inflammatory and immune responses.
A pruritic papulovesicular dermatitis occurring as a reaction to many endogenous and exogenous agents (Dorland, 27th ed).
Immunoglobulin molecules having a specific amino acid sequence by virtue of which they interact only with the ANTIGEN (or a very similar shape) that induced their synthesis in cells of the lymphoid series (especially PLASMA CELLS).
White blood cells formed in the body's lymphoid tissue. The nucleus is round or ovoid with coarse, irregularly clumped chromatin while the cytoplasm is typically pale blue with azurophilic (if any) granules. Most lymphocytes can be classified as either T or B (with subpopulations of each), or NATURAL KILLER CELLS.
An immunologic deficiency state characterized by an extremely low level of generally all classes of gamma-globulin in the blood.
Lymphocytes responsible for cell-mediated immunity. Two types have been identified - cytotoxic (T-LYMPHOCYTES, CYTOTOXIC) and helper T-lymphocytes (T-LYMPHOCYTES, HELPER-INDUCER). They are formed when lymphocytes circulate through the THYMUS GLAND and differentiate to thymocytes. When exposed to an antigen, they divide rapidly and produce large numbers of new T cells sensitized to that antigen.
Infection with roundworms of the genus ANISAKIS. Human infection results from the consumption of fish harboring roundworm larvae. The worms may cause acute NAUSEA; VOMITING; or penetrate into the wall of the DIGESTIVE TRACT where they give rise to EOSINOPHILIC GRANULOMA in the STOMACH; INTESTINES; or the OMENTUM.
A plant genus of the family RHAMNACEAE. Members contain nummularogenin (a spirostane) and is the source of an edible fruit.
Non-antibody proteins secreted by inflammatory leukocytes and some non-leukocytic cells, that act as intercellular mediators. They differ from classical hormones in that they are produced by a number of tissue or cell types rather than by specialized glands. They generally act locally in a paracrine or autocrine rather than endocrine manner.
Chemically stimulated aggregation of cell surface receptors, which potentiates the action of the effector cell.
An in vitro test used in the diagnosis of allergies including drug hypersensitivity. The allergen is added to the patient's white blood cells and the subsequent histamine release is measured.
Allelic variants of the gamma-immunoglobulin heavy chain (IMMUNOGLOBULIN GAMMA-CHAINS) encoded by ALLELES of IMMUNOGLOBULIN HEAVY CHAIN GENES.
Proteins synthesized by organisms belonging to the phylum ARTHROPODA. Included in this heading are proteins from the subdivisions ARACHNIDA; CRUSTACEA; and HORSESHOE CRABS. Note that a separate heading for INSECT PROTEINS is listed under this heading.
A milky, product excreted from the latex canals of a variety of plant species that contain cauotchouc. Latex is composed of 25-35% caoutchouc, 60-75% water, 2% protein, 2% resin, 1.5% sugar & 1% ash. RUBBER is made by the removal of water from latex.(From Concise Encyclopedia Biochemistry and Molecular Biology, 3rd ed). Hevein proteins are responsible for LATEX HYPERSENSITIVITY. Latexes are used as inert vehicles to carry antibodies or antigens in LATEX FIXATION TESTS.
Inflammation of the NASAL MUCOSA, the mucous membrane lining the NASAL CAVITIES.
The thin, yellow, serous fluid secreted by the mammary glands during pregnancy and immediately postpartum before lactation begins. It consists of immunologically active substances, white blood cells, water, protein, fat, and carbohydrates.
Tests involving inhalation of allergens (nebulized or in dust form), nebulized pharmacologically active solutions (e.g., histamine, methacholine), or control solutions, followed by assessment of respiratory function. These tests are used in the diagnosis of asthma.
Morphologic alteration of small B LYMPHOCYTES or T LYMPHOCYTES in culture into large blast-like cells able to synthesize DNA and RNA and to divide mitotically. It is induced by INTERLEUKINS; MITOGENS such as PHYTOHEMAGGLUTININS, and by specific ANTIGENS. It may also occur in vivo as in GRAFT REJECTION.
Transfer of immunity from immunized to non-immune host by administration of serum antibodies, or transplantation of lymphocytes (ADOPTIVE TRANSFER).
Cell surface molecules on cells of the immune system that specifically bind surface molecules or messenger molecules and trigger changes in the behavior of cells. Although these receptors were first identified in the immune system, many have important functions elsewhere.
A family of neutral serine proteases with CHYMOTRYPSIN-like activity. Chymases are primarily found in the SECRETORY GRANULES of MAST CELLS and are released during mast cell degranulation.
Local surface sites on antibodies which react with antigen determinant sites on antigens (EPITOPES.) They are formed from parts of the variable regions of FAB FRAGMENTS.
The complex formed by the binding of antigen and antibody molecules. The deposition of large antigen-antibody complexes leading to tissue damage causes IMMUNE COMPLEX DISEASES.
Small antigenic determinants capable of eliciting an immune response only when coupled to a carrier. Haptens bind to antibodies but by themselves cannot elicit an antibody response.
A technique that combines protein electrophoresis and double immunodiffusion. In this procedure proteins are first separated by gel electrophoresis (usually agarose), then made visible by immunodiffusion of specific antibodies. A distinct elliptical precipitin arc results for each protein detectable by the antisera.
A genus of nematodes of the superfamily ASCARIDOIDEA. Its organisms are found in the stomachs of marine animals and birds. Human infection occurs by ingestion of raw fish that contain larvae.
Species of European house dust mite, in the family PYROGLYPHIDAE. It is the most commonly found house dust mite.
Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood.
Ordered rearrangement of B-lymphocyte variable gene regions of the IMMUNOGLOBULIN HEAVY CHAINS, thereby contributing to antibody diversity. It occurs during the first stage of differentiation of the IMMATURE B-LYMPHOCYTES.
A species of parasitic nematode causing Malayan filariasis and having a distribution centering roughly on the Malay peninsula. The life cycle of B. malayi is similar to that of WUCHERERIA BANCROFTI, except that in most areas the principal mosquito vectors belong to the genus Mansonia.
Ordered rearrangement of B-lymphocyte variable gene regions coding for the IMMUNOGLOBULIN CHAINS, thereby contributing to antibody diversity. It occurs during the differentiation of the IMMATURE B-LYMPHOCYTES.
Blood of the fetus. Exchange of nutrients and waste between the fetal and maternal blood occurs via the PLACENTA. The cord blood is blood contained in the umbilical vessels (UMBILICAL CORD) at the time of delivery.
A round-to-oval mass of lymphoid tissue embedded in the lateral wall of the PHARYNX. There is one on each side of the oropharynx in the fauces between the anterior and posterior pillars of the SOFT PALATE.
A technique using antibodies for identifying or quantifying a substance. Usually the substance being studied serves as antigen both in antibody production and in measurement of antibody by the test substance.
Proteins prepared by recombinant DNA technology.
Immunologic techniques involved in diagnosis.
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
The major interferon produced by mitogenically or antigenically stimulated LYMPHOCYTES. It is structurally different from TYPE I INTERFERON and its major activity is immunoregulation. It has been implicated in the expression of CLASS II HISTOCOMPATIBILITY ANTIGENS in cells that do not normally produce them, leading to AUTOIMMUNE DISEASES.
A protein present in the cell wall of most Staphylococcus aureus strains. The protein selectively binds to the Fc region of human normal and myeloma-derived IMMUNOGLOBULIN G. It elicits antibody activity and may cause hypersensitivity reactions due to histamine release; has also been used as cell surface antigen marker and in the clinical assessment of B lymphocyte function.
Elements of limited time intervals, contributing to particular results or situations.
Serum that contains antibodies. It is obtained from an animal that has been immunized either by ANTIGEN injection or infection with microorganisms containing the antigen.
The insertion of recombinant DNA molecules from prokaryotic and/or eukaryotic sources into a replicating vehicle, such as a plasmid or virus vector, and the introduction of the resultant hybrid molecules into recipient cells without altering the viability of those cells.
A family of neutral serine proteases with TRYPSIN-like activity. Tryptases are primarily found in the SECRETORY GRANULES of MAST CELLS and are released during mast cell degranulation.
Differentiation antigens residing on mammalian leukocytes. CD stands for cluster of differentiation, which refers to groups of monoclonal antibodies that show similar reactivity with certain subpopulations of antigens of a particular lineage or differentiation stage. The subpopulations of antigens are also known by the same CD designation.
Substances of fungal origin that have antigenic activity.
Test for tissue antigen using either a direct method, by conjugation of antibody with fluorescent dye (FLUORESCENT ANTIBODY TECHNIQUE, DIRECT) or an indirect method, by formation of antigen-antibody complex which is then labeled with fluorescein-conjugated anti-immunoglobulin antibody (FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT). The tissue is then examined by fluorescence microscopy.
Proteins secreted by the prostate gland. The major secretory proteins from the human prostate gland include PROSTATE-SPECIFIC ANTIGEN, prostate-specific acid phosphatase, prostate-specific membrane antigen, and prostate-specific protein-94.
An amine derived by enzymatic decarboxylation of HISTIDINE. It is a powerful stimulant of gastric secretion, a constrictor of bronchial smooth muscle, a vasodilator, and also a centrally acting neurotransmitter.
Conjunctivitis due to hypersensitivity to various allergens.
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
A condition characterized by infiltration of the lung with EOSINOPHILS due to inflammation or other disease processes. Major eosinophilic lung diseases are the eosinophilic pneumonias caused by infections, allergens, or toxic agents.
Technique using an instrument system for making, processing, and displaying one or more measurements on individual cells obtained from a cell suspension. Cells are usually stained with one or more fluorescent dyes specific to cell components of interest, e.g., DNA, and fluorescence of each cell is measured as it rapidly transverses the excitation beam (laser or mercury arc lamp). Fluorescence provides a quantitative measure of various biochemical and biophysical properties of the cell, as well as a basis for cell sorting. Other measurable optical parameters include light absorption and light scattering, the latter being applicable to the measurement of cell size, shape, density, granularity, and stain uptake.
Globulins of milk obtained from the WHEY.
Specialized forms of antibody-producing B-LYMPHOCYTES. They synthesize and secrete immunoglobulin. They are found only in lymphoid organs and at sites of immune responses and normally do not circulate in the blood or lymph. (Rosen et al., Dictionary of Immunology, 1989, p169 & Abbas et al., Cellular and Molecular Immunology, 2d ed, p20)
Antibodies that react with self-antigens (AUTOANTIGENS) of the organism that produced them.
Health care professionals, technicians, and assistants staffing LABORATORIES in research or health care facilities.
In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.
Mercury chloride (HgCl2). A highly toxic compound that volatizes slightly at ordinary temperature and appreciably at 100 degrees C. It is corrosive to mucous membranes and used as a topical antiseptic and disinfectant.
The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.
Technique involving the diffusion of antigen or antibody through a semisolid medium, usually agar or agarose gel, with the result being a precipitin reaction.
Genes and gene segments encoding the IMMUNOGLOBULIN LIGHT CHAINS. Gene segments of the light chain genes are designated as V (variable), J (joining), and C (constant).
Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations, or by parent x offspring matings carried out with certain restrictions. All animals within an inbred strain trace back to a common ancestor in the twentieth generation.
Cells artificially created by fusion of activated lymphocytes with neoplastic cells. The resulting hybrid cells are cloned and produce pure MONOCLONAL ANTIBODIES or T-cell products, identical to those produced by the immunologically competent parent cell.
An infant during the first month after birth.
A contact dermatitis due to allergic sensitization to various substances. These substances subsequently produce inflammatory reactions in the skin of those who have acquired hypersensitivity to them as a result of prior exposure.
The ordered rearrangement of gene regions by DNA recombination such as that which occurs normally during development.
Noises, normal and abnormal, heard on auscultation over any part of the RESPIRATORY TRACT.
A species of trematode blood flukes of the family Schistosomatidae. It is common in the Nile delta. The intermediate host is the planorbid snail. This parasite causes schistosomiasis mansoni and intestinal bilharziasis.
Washing liquid obtained from irrigation of the lung, including the BRONCHI and the PULMONARY ALVEOLI. It is generally used to assess biochemical, inflammatory, or infection status of the lung.
An anthelmintic used in most schistosome and many cestode infestations.
The sum of the weight of all the atoms in a molecule.
Ordered rearrangement of B-lymphocyte variable gene regions coding for the kappa or lambda IMMUNOGLOBULIN LIGHT CHAINS, thereby contributing to antibody diversity. It occurs during the second stage of differentiation of the IMMATURE B-LYMPHOCYTES.
A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine).
Syndromes in which there is a deficiency or defect in the mechanisms of immunity, either cellular or humoral.
Substances elaborated by bacteria that have antigenic activity.
A dysgammaglobulinemia characterized by a deficiency of IMMUNOGLOBULIN A.
A plant species of the family FABACEAE that yields edible seeds, the familiar peanuts, which contain protein, oil and lectins.
Insects of the order Dictyoptera comprising several families including Blaberidae, BLATTELLIDAE, Blattidae (containing the American cockroach PERIPLANETA americana), Cryptocercidae, and Polyphagidae.
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
Infections with nematodes of the superfamily FILARIOIDEA. The presence of living worms in the body is mainly asymptomatic but the death of adult worms leads to granulomatous inflammation and permanent fibrosis. Organisms of the genus Elaeophora infect wild elk and domestic sheep causing ischemic necrosis of the brain, blindness, and dermatosis of the face.
Proteins isolated from the roots of the pokeweed, Phytolacca americana, that agglutinate some erythrocytes, stimulate mitosis and antibody synthesis in lymphocytes, and induce activation of plasma cells.
Electrophoresis in which a polyacrylamide gel is used as the diffusion medium.
Serum glycoproteins participating in the host defense mechanism of COMPLEMENT ACTIVATION that creates the COMPLEMENT MEMBRANE ATTACK COMPLEX. Included are glycoproteins in the various pathways of complement activation (CLASSICAL COMPLEMENT PATHWAY; ALTERNATIVE COMPLEMENT PATHWAY; and LECTIN COMPLEMENT PATHWAY).
Earth or other matter in fine, dry particles. (Random House Unabridged Dictionary, 2d ed)
Recombinant proteins produced by the GENETIC TRANSLATION of fused genes formed by the combination of NUCLEIC ACID REGULATORY SEQUENCES of one or more genes with the protein coding sequences of one or more genes.
Specific molecular sites on the surface of various cells, including B-lymphocytes and macrophages, that combine with IMMUNOGLOBULIN Gs. Three subclasses exist: Fc gamma RI (the CD64 antigen, a low affinity receptor), Fc gamma RII (the CD32 antigen, a high affinity receptor), and Fc gamma RIII (the CD16 antigen, a low affinity receptor).
Diseases caused by factors involved in one's employment.

Interleukin-8 receptor modulates IgE production and B-cell expansion and trafficking in allergen-induced pulmonary inflammation. (1/5385)

We examined the role of the interleukin-8 (IL-8) receptor in a murine model of allergen-induced pulmonary inflammation using mice with a targeted deletion of the murine IL-8 receptor homologue (IL-8r-/-). Wild-type (Wt) and IL-8r-/- mice were systemically immunized to ovalbumin (OVA) and were exposed with either single or multiple challenge of aerosolized phosphate-buffered saline (OVA/PBS) or OVA (OVA/OVA). Analysis of cells recovered from bronchoalveolar lavage (BAL) revealed a diminished recruitment of neutrophils to the airway lumen after single challenge in IL-8r-/- mice compared with Wt mice, whereas multiply challenged IL-8r-/- mice had increased B cells and fewer neutrophils compared with Wt mice. Both Wt and IL-8r-/- OVA/OVA mice recruited similar numbers of eosinophils to the BAL fluid and exhibited comparable degrees of pulmonary inflammation histologically. Both total and OVA-specific IgE levels were greater in multiply challenged IL-8r-/- OVA/OVA mice than in Wt mice. Both the IL-8r-/- OVA/OVA and OVA/PBS mice were significantly less responsive to methacholine than their respective Wt groups, but both Wt and IL-8r mice showed similar degrees of enhancement after multiple allergen challenge. The data demonstrate that the IL-8r modulates IgE production, airway responsiveness, and the composition of the cells (B cells and neutrophils) recruited to the airway lumen in response to antigen.  (+info)

gp49B1 inhibits IgE-initiated mast cell activation through both immunoreceptor tyrosine-based inhibitory motifs, recruitment of src homology 2 domain-containing phosphatase-1, and suppression of early and late calcium mobilization. (2/5385)

We define by molecular, pharmacologic, and physiologic approaches the proximal mechanism by which the immunoglobulin superfamily member gp49B1 inhibits mast cell activation mediated by the high affinity Fc receptor for IgE (FcepsilonRI). In rat basophilic leukemia-2H3 cells expressing transfected mouse gp49B1, mutation of tyrosine to phenylalanine in either of the two immunoreceptor tyrosine-based inhibitory motifs of the gp49B1 cytoplasmic domain partially suppressed gp49B1-mediated inhibition of exocytosis, whereas mutation of both abolished inhibitory capacity. Sodium pervanadate elicited tyrosine phosphorylation of native gp49B1 and association of the tyrosine phosphatases src homology 2 domain-containing phosphatase-1 (SHP-1) and SHP-2 in mouse bone marrow-derived mast cells (mBMMCs). SHP-1 associated transiently with gp49B1 within 1 min after coligation of gp49B1 with cross-linked FcepsilonRI in mBMMCs. SHP-1-deficient mBMMCs exhibited a partial loss of gp49B1-mediated inhibition of FcepsilonRI-induced exocytosis at concentrations of IgE providing optimal exocytosis, revealing a central, but not exclusive, SHP-1 requirement in the counter-regulatory pathway. Coligation of gp49B1 with cross-linked FcepsilonRI on mBMMCs inhibited early release of calcium from intracellular stores and subsequent influx of extracellular calcium, consistent with SHP-1 participation. Because exocytosis is complete within 2 min in mBMMCs, our studies establish a role for SHP-1 in the initial counter-regulatory cellular responses whereby gp49B1 immunoreceptor tyrosine-based inhibition motifs rapidly transmit inhibition of FcepsilonRI-mediated exocytosis.  (+info)

Hyper-IgE syndrome with recurrent infections--an autosomal dominant multisystem disorder. (3/5385)

BACKGROUND: The hyper-IgE syndrome with recurrent infections is a rare immunodeficiency characterized by recurrent skin and pulmonary abscesses and extremely elevated levels of IgE in serum. Associated facial and skeletal features have been recognized, but their frequency is unknown, and the genetic basis of the hyper-IgE syndrome is poorly understood. METHODS: We studied 30 patients with the hyper-IgE syndrome and 70 of their relatives. We took histories, reviewed records, performed physical and dental examinations, took anthropometric measurements, and conducted laboratory studies. RESULTS: Nonimmunologic features of the hyper-IgE syndrome were present in all patients older than eight years. Seventy-two percent had the previously unrecognized feature of failure or delay of shedding of the primary teeth owing to lack of root resorption. Common findings among patients were recurrent fractures (in 57 percent of patients), hyperextensible joints (in 68 percent), and scoliosis (in 76 percent of patients 16 years of age or older). The classic triad of abscesses, pneumonia, and an elevated IgE level was identified in 77 percent of all patients and in 85 percent of those older than eight. In 6 of 23 adults (26 percent), IgE levels declined over time and came closer to or fell within the normal range. Autosomal dominant transmission of the hyper-IgE syndrome was found, but with variable expressivity. Of the 27 relatives at risk for inheriting the hyper-IgE syndrome, 10 were fully affected, 11 were unaffected, and 6 had combinations of mild immunologic, dental, and skeletal features of the hyper-IgE syndrome. CONCLUSIONS: The hyper-IgE syndrome is a multisystem disorder that affects the dentition, the skeleton, connective tissue, and the immune system. It is inherited as a single-locus autosomal dominant trait with variable expressivity.  (+info)

Exhaled and nasal NO levels in allergic rhinitis: relation to sensitization, pollen season and bronchial hyperresponsiveness. (4/5385)

Exhaled nitric oxide is a potential marker of lower airway inflammation. Allergic rhinitis is associated with asthma and bronchial hyperresponsiveness. To determine whether or not nasal and exhaled NO concentrations are increased in allergic rhinitis and to assess the relation between hyperresponsiveness and exhaled NO, 46 rhinitic and 12 control subjects, all nonasthmatic nonsmokers without upper respiratory tract infection, were randomly selected from a large-scale epidemiological survey in Central Norway. All were investigated with flow-volume spirometry, methacholine provocation test, allergy testing and measurement of nasal and exhaled NO concentration in the nonpollen season. Eighteen rhinitic subjects completed an identical follow-up investigation during the following pollen season. Exhaled NO was significantly elevated in allergic rhinitis in the nonpollen season, especially in perennially sensitized subjects, as compared with controls (p=0.01), and increased further in the pollen season (p=0.04), mainly due to a two-fold increase in those with seasonal sensitization. Nasal NO was not significantly different from controls in the nonpollen season and did not increase significantly in the pollen season. Exhaled NO was increased in hyperresponsive subjects, and decreased significantly after methacholine-induced bronchoconstriction, suggesting that NO production occurs in the peripheral airways. In allergic rhinitis, an increase in exhaled nitric oxide on allergen exposure, particularly in hyperresponsive subjects, may be suggestive of airway inflammation and an increased risk for developing asthma.  (+info)

Immunosurveillance of alglucerase enzyme therapy for Gaucher patients: induction of humoral tolerance in seroconverted patients after repeat administration. (5/5385)

Alglucerase, a macrophage-targeted enzyme replacement therapy for Gaucher disease, has been successfully used for several years to improve clinical symptoms and reverse disease progression. As part of an immunosurveillance program, 1,122 Gaucher patients were monitored for antibody response to glucocerebrosidase, the active component of alglucerase. Seroconversion was detected in 142 patients (12.8%) by enzyme-linked immunosorbent assay (ELISA) and confirmed by radioimmunoprecipitation. The majority (75%) of the seroconverted population had no detectable levels of circulating inhibitory antibody as assessed by in vitro inhibition of enzymatic activity of the therapeutic molecule. Of the remaining patients with putative inhibitory antibodies, the majority had only low levels of serum inhibitory activity, which was transient. A very small number of patients were identified as developing true neutralizing antibodies, as defined by the development of antibodies that impacted clinical efficacy. Many of the patient antibody responses were also diminished with time. Eighty-two of the 142 seroconverted patients have stopped producing antibody to the molecule and appear tolerized. The mean time for humoral tolerization was 28 months from initiation of therapy. Of 64 seroconverted patients followed for at least 30 months of therapy, the tolerization rate was 93%. These results show that although 12.8% of the patients on therapy developed antibodies to the molecule, 90% of these patients became tolerized over time.  (+info)

Involvement of tachykinin receptors in sensitisation to cow's milk proteins in guinea pigs. (6/5385)

BACKGROUND: There is growing evidence for a pivotal role for tachykinins in gut neuroimmune interactions. AIMS: To determine whether NK1, NK2, and NK3 tachykinin receptors are involved in milk protein induced allergic sensitisation. METHODS: Eight groups of 12 Dunkin-Hartley guinea pigs (250-300 g) were used. Four groups were sensitised to milk proteins for three weeks. During this period, these animals were injected intraperitoneally each day with NK1 (SR 140333; 0.3 mg/kg), NK2 (SR 48968; 5 mg/kg), or NK3 (SR 142801; 5 mg/kg) receptor antagonist or vehicle. The fifth group had water available instead of milk and was used as a non-sensitised control. The three other groups received the NK receptor antagonists for three weeks but were not sensitised to milk proteins. RESULTS: Sensitised animals treated with NK1 and NK3 receptor antagonists had both lower IgE and IgG serum titres, evaluated by passive cutaneous anaphylaxis, and lower specific IgG serum titres, determined by enzyme linked immunosorbent assay (ELISA), than vehicle treated animals. Sensitisation induced an increase in intestinal mast cell number which was abolished by treatment with the NK1 receptor antagonist. Antigenic challenge-induced jejunal hypersecretion was also blocked by treatment with the NK1 receptor antagonist. CONCLUSION: In guinea pigs, NK1 and NK3 but not NK2 receptors are involved in sensitisation to cow's milk. However, NK1 but not NK3 receptor antagonists abolish both the hypermastocytosis induced by food allergy and the hypersecretion induced by antigenic challenge, suggesting different roles for NK1 and NK3 receptors in the mechanisms of sensitisation to beta-lactoglobulin.  (+info)

Induction of Ig somatic hypermutation and class switching in a human monoclonal IgM+ IgD+ B cell line in vitro: definition of the requirements and modalities of hypermutation. (7/5385)

Partly because of the lack of a suitable in vitro model, the trigger(s) and the mechanism(s) of somatic hypermutation in Ig genes are largely unknown. We have analyzed the hypermutation potential of human CL-01 lymphocytes, our monoclonal model of germinal center B cell differentiation. These cells are surface IgM+ IgD+ and, in the absence of T cells, switch to IgG, IgA, and IgE in response to CD40:CD40 ligand engagement and exposure to appropriate cytokines. We show here that CL-01 cells can be induced to effectively mutate the expressed VHDJH-C mu, VHDJH-C delta, VHDJH-C gamma, VHDJH-C alpha, VHDJH-C epsilon, and V lambda J lambda-C lambda transcripts before and after Ig class switching in a stepwise fashion. In these cells, induction of somatic mutations required cross-linking of the surface receptor for Ag and T cell contact through CD40:CD40 ligand and CD80: CD28 coengagement. The induced mutations showed intrinsic features of Ig V(D)J hypermutation in that they comprised 110 base substitutions (97 in the heavy chain and 13 in the lambda-chain) and only 2 deletions and targeted V(D)J, virtually sparing CH and C lambda. These mutations were more abundant in secondary VHDJH-C gamma than primary VHDJH-C mu transcripts and in V(D)J-C than V lambda J lambda-C lambda transcripts. These mutations were also associated with coding DNA strand polarity and showed an overall rate of 2.42 x 10(-4) base changes/cell division in VHDJH-CH transcripts. Transitions were favored over transversions, and G nucleotides were preferentially targeted, mainly in the context of AG dinucleotides. Thus, in CL-01 cells, Ig somatic hypermutation is readily inducible by stimuli different from those required for class switching and displays discrete base substitution modalities.  (+info)

Evidence for the involvement of IgE-basophil system in acute serum sickness. (8/5385)

The role of the basophils in acute serum sickness of rabbits was examined by monitoring daily the absolute number of basophils before, during and after the disease period. After antigen (bovine serum albumin, BSA) elimination, levels of serum IgE and in vitro basophil degranulation in the presence of BSA were determined. The results showed that the onset of glomerular lesions depends upon the simultaneous occurrence of circulating immune complexes greater than 19 S and of an in vivo basophil depletion--probably equivalent to degranulation--reaching 70% of the pre-disease number. Post-disease antigen-dependent in vitro degranulation of the basophils and levels of serum IgE anti BSA did not prove to be good indexes of basophil sensitization. Our data suggest that basophils are instrumental at early stages of the deposition of immune complexes, most probably through their sensitization by membrane-bound IgE antibodies.  (+info)

Methods: This was a case-control study involving 25 asymptomatic contact lens wearers, 25 patients with type 1 allergic conjunctivitis, and 25 age- and sex-matched healthy controls. Total serum immunoglobulin E levels were detected by enzyme-linked immunosorbent assay. Serum-specific IgE analysis against the listed indoor, food, and outdoor allergens were studied by immunofluorescence assay for participants whose total serum immunoglobulin E levels were ,100 IU/mL. Pearsons and Spearmans correlations were used for bivariate analysis. Statistical significance was accepted at the 0.05 level ...
TY - JOUR. T1 - Serum total IgE levels and CD14 on chromosome 5q31 [1]. AU - Gao, P. S.. AU - Mao, X. Q.. AU - Baldini, M.. AU - Roberts, M. H.. AU - Adra, C. N.. AU - Shirakawa, T.. AU - Holt, P. G.. AU - Martinez, F. D.. AU - Hopkin, J. M.. PY - 1999. Y1 - 1999. UR - http://www.scopus.com/inward/record.url?scp=0032847362&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=0032847362&partnerID=8YFLogxK. U2 - 10.1034/j.1399-0004.1999.560213.x. DO - 10.1034/j.1399-0004.1999.560213.x. M3 - Letter. C2 - 10517256. AN - SCOPUS:0032847362. VL - 56. SP - 164. EP - 165. JO - Clinical Genetics. JF - Clinical Genetics. SN - 0009-9163. IS - 2. ER - ...
Effect of vitamin E (alpha-tocopheryl acetate and alpha-tocopheryl nicotinate) on IgE antibody formation in mice was investgiated . Female BALB/c mice were immunized with dinitrophenylated ascaris protein (DNP-As) and aluminium hydroxide gel (alum). Supplementation of vitamin E in diets or oral administration of vitamin E mixed with sesame oil resulted in a suppression of IgE antibody formation. On the contrary to IgE antibody formation, IgM or IgG (hemagglutinin; HA) formation was significantly enhanced. These results indicate that vitamin E is capable of suppressing IgE antibody formation and enhancing non-IgE antibody formation. ...
TY - JOUR. T1 - Genetic loci determining total immunoglobulin E levels from birth through adulthood. AU - Yao, Tsung Chieh. AU - Chung, Ren Hua. AU - Lin, Chung Yen. AU - Tsai, Pei Chien. AU - Chang, Wei Chiao. AU - Yeh, Kuo Wei. AU - Tsai, Ming Han. AU - Liao, Sui Ling. AU - Hua, Man Chin. AU - Lai, Shen Hao. AU - Chen, Li Chen. AU - Chang, Su Wei. AU - Yu, Ya Wen. AU - Hsu, Jing Ya. AU - Chang, Su Ching. AU - Cheng, Wen Chih. AU - Hu, Donglei. AU - Hong, Xiumei. AU - Burchard, Esteban G.. AU - Wang, Xiaobin. AU - Tzeng, Jung Ying. AU - Tsai, Hui Ju. AU - Huang, Jing Long. PY - 2019/3/1. Y1 - 2019/3/1. UR - http://www.scopus.com/inward/record.url?scp=85057536131&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=85057536131&partnerID=8YFLogxK. U2 - 10.1111/all.13654. DO - 10.1111/all.13654. M3 - Letter. AN - SCOPUS:85057536131. VL - 74. SP - 621. EP - 625. JO - Allergy: European Journal of Allergy and Clinical Immunology. JF - Allergy: European Journal of Allergy and Clinical ...
An allergen-specific immunoglobulin E (IgE) blood test is done to check whether a person is allergic to a particular substance.. An allergic reaction occurs when the immune system overreacts to something, often in the environment, thats harmless to most people. To protect the body from this perceived threat, or allergen, the immune system of an allergic person produces antibodies called immunoglobulin E.. IgE antibodies are found mostly in the lungs, skin, and mucous membranes. They cause mast cells (a type of cell involved in the bodys immune response) to release chemicals, including histamine, into the bloodstream. Its these chemicals that bring on many of the allergy symptoms that affect a persons eyes, nose, throat, lungs, skin, or gastrointestinal tract.. Because IgE antibodies are unique to each allergen (for example, IgE produced in response to pollen differs from IgE produced after a bee sting), checking for specific variants in the blood can help determine if an allergy is ...
In this study altered immune response as measured by total serum IgE level among symptomatic HIV infected patients, asymptomatic HIV positive individuals and healthy controls with and without helminths co-infection and the impact of deworming and/or ART on these immune activation was assessed within defined groups of population from tropical settings of Ethiopia where both HIV and helminths infections are common. Consistent with the earlier suggestions [25-27] that Africans generally present with elevated total serum IgE levels and our previous observations [14-16], patients in this study also showed a high total serum IgE level as shown by more than three-folds of the total IgE above the reference ranges irrespective of HIV and helminths co-infections. The highly significant correlation between helminth egg intensity and serum IgE level may partly explain the elevated total serum IgE levels observed in sub-Saharan regions, where heavy helminthic infections are widespread [14-16, 25-27]. It ...
Background: Dry eye disease (DED) is a multifactorial disease of the tears and ocular surface. No epidemiologic reports have yet been published about the relationship between DED and allergic rhinitis or sensitization to allergens. Objective: To investigate the association between DED and allergic conditions in the general adult Korean population. Methods: This population-based cross-sectional study included 17,542 individuals (ages ,= 19 years) who participated in the Korea National Health and Nutrition Examination Survey (KNHANES) from 2010 to 2012. Data for total serum immunoglobulin E (IgE) and allergen-specific IgE levels were available for 1857 subjects. Data were analyzed by using logistic regression to determine the association of DED with allergy or allergic conditions, including allergic rhinitis, atopic dermatitis, asthma, increased total serum IgE, and sensitization to house-dust mite (Dermatophagoides farinae), dog, and cockroach allergens. Results: The prevalence of DED, allergic ...
Nitric oxide, a relatively stable free radical, is increased in exhaled air and plasma of people with asthma compared with that in healthy individuals, and is increasingly implicated in the pathogenesis of inflammation in asthma.8,25 Nitric oxide produced in the lungs is an important regulator of airway events, including modifying airway tone, regulating pulmonary vascular tone, stimulating mucin secretion, modulating mucociliary clearance through effects on ciliary beat frequency, and immune surveillance including tumoricidal and bactericidal effects.26 Studies of NOS in asthma have been focused on iNOS as iNOS was shown to be up regulated in patients with asthma and is believed to represent the major source of nitric oxide in the lungs.27 NOS2A (iNOS) has been identified as a calcium-independent isoform, which was detected in the brain, lungs, and liver of rats after endotoxin treatment.28 The transcriptional activation of iNOS in these cells is regulated by endogeneous mediators (such as ...
Dr. Ginsberg responded: Probably not. High ige levels are usually related to allergic disorders and some lung disorders. |a href=/topics/cancer track_data={
PubMed Central Canada (PMC Canada) provides free access to a stable and permanent online digital archive of full-text, peer-reviewed health and life sciences research publications. It builds on PubMed Central (PMC), the U.S. National Institutes of Health (NIH) free digital archive of biomedical and life sciences journal literature and is a member of the broader PMC International (PMCI) network of e-repositories.
The development of allergic diseases seems to be associated with the composition of the gut microbial ecosystem. High counts of potential pathogens, such as clostridia, are associated with clinical manifestations of allergy and IgE antibody formation.
Background: Pediatric bronchial asthma is associated with considerable morbidity. The study was carried out to examine the association of Human Leukocyte Antigen (HLA)- Class II with the disease as we found no similar study on Asian Indian population. Objective: To define the HLA-Class II antigens in Asian Indian pediatric patients with asthma. Methods: A total of 103 children with asthma and 152 controls were analysed for HLA Class II (DRB1, DQB1and DPB1) by PCR-SSP (Sequence Specific Primers) method. Total serum IgE levels were determined by ELISA assay. Results: A positive family history was recorded in 59 patients (57%) and 13 (8.5%) of healthy controls. Serum IgE levels were more than normal range in 72% of the patients and 33% of healthy subjects with mean values of 4877 and 627 IU/ml, respectively. DRB1*04 and DQB1*03 showed significant positive relations while DRB1*15 showed a negative association with asthma. DQB1*02 was more common in healthy individuals but was not statistically significant.
It has been suggested that neutrophils may be involved in the late-phase reaction of immunoglobulin E (IgE)-dependent hypersensitivity states. However, the identity of neutrophil-associated molecules inducing the release of mediators remains unclear. In this report, we demonstrate that human neutrophils from normal donors or from patients with inflammatory disorders could bind myeloma IgE proteins, especially after desialylation. Northern blot, immunoprecipitation, and flow cytometry analyses revealed that neutrophils did not express Fc epsilon RII/CD23, but rather Mac-2/epsilon binding protein (BP), belonging to the S-type lectin family. Similarly to IgA used as positive control, myeloma IgE proteins, as well as polyclonal IgE antibodies with or without antibody specificity, were both capable of inducing a neutrophil respiratory burst. Anti-Mac-2 but not anti-CD23 mAb strongly decreased the IgE-dependent activation of neutrophils, induced either by the specific antigen or by anti-IgE ...
Selective suppression of IgE antibody response was demonstrated. Preadministration of DNP-coupled mycobacterium (DNP-Tbc) inhibited the formation of anti-DNP IgE antibody induced by DNP-OA without any suppressive effect on anti-DNP IgG antibody response. Secondary anti-DNP IgE antibody response by DNP-OA was also significantly depressed by the preadministration of DNP-Tbc. Anti-OA IgE antibody response induced by DNP-OA was also depressed by DNP-Tbc, whereas anti-OA IgE antibody response induced by PAB-OA was not affected by the preadministration of DNP-Tbc. Preimmunization with DNP-MGG induced much higher anti-DNP IgG antibody response than DNP-Tbc, but DNP-MGG did not suppress the induction of anti-DNP IgE antibody. The transfer of DNP-Tbc-primed spleen cells into normal mice depressed anti-DNP IgE antibody response. B cell-depleted cell populations also showed a comparable inhibitory effect to that of unfractionated DNP-Tbc primed cells. In the adoptive cell transfer experiment, ...
CCDs (cross-reactive carbohydrate determinants) are carbohydrate side chains inducing the production of specific IgE antibodies. A Type I allergy is caused by the formation of specific IgE antibodies against allergens. Most allergens are proteins. In eucaryotic organisms, many proteins are subjected to post-translational glycosylation and therefore carry carbohydrate side chains. Specific IgE antibodies are produced by the immune system against the real allergens but also against carbohydrate side chains of allergens (anti-CCD IgE) of plant origin, of insects, of molluscs and of latex. The anti-CCD IgE also leads to cross-reactions with unrelated proteins and therefore are called cross-reactive carbohydrate determinants (CCD).. CCDs do not cause allergic symptoms. Approximately 25 % of allergic patients produce anti-CCD IgEs, which, however, do not trigger allergic symptoms and therefore most likely have no clinical relevance. This low clinical significance was thought to be due to low binding ...
OBJECTIVE: The goal was to examine the relationship between age at the introduction of solid foods during the first year of life and allergic sensitization in 5-year-old children.. METHODS: We analyzed data from the Finnish Type 1 Diabetes Prediction and Prevention nutrition study, a prospective, birth cohort study. We studied 994 children with HLA-conferred susceptibility to type 1 diabetes mellitus for whom information on breastfeeding, age at the introduction of solid foods, and allergen-specific immunoglobulin E levels at 5 years was available. The association between age at the introduction of solid foods and allergic sensitization was analyzed by using logistic regression.. RESULTS: The median duration of exclusive breastfeeding was 1.8 months (range: 0-10 months). After adjustment for potential confounders, late introduction of potatoes (,4 months), oats (,5 months), rye (,7 months), wheat (,6 months), meat (,5.5 months), fish (,8.2 months), and eggs (,10.5 months) was significantly ...
Allergic asthma is characterized by airway hyperresponsiveness to specific and non-specific stimuli with elevated serum IgE levels and eosinophilic inflammation. It is well known that allergen-specific CD4 + type 2, T-helper (Th2) cells and immunoglobulin E (IgE)-sensitized mast cells are key players in the allergic response. Therefore, therapeutic strategies that induce regulatory T cells (Tregs) to suppress Th2-cell responses and inhibit IgE-mediated activation on mast cells seem to have the greatest potential to efficiently inhibit allergen-induced disorders. Short-chain fatty acids (SCFAs) have anti-inflammatory and immuno-suppressive properties and are considered especially good candidates for the role. Actually, our preliminary results showed that SCFA-phenylbutyrate (PB) induced tolerogenic dendritic cells, enhanced the generation of splenic Foxp3 + Tregs and inhibited mast cell degranulation. PB also expressed a preventive effect in an ovalbumin-induced asthmatic animal model. Therefore, ...
RESULTS. The median patient age was 8.2 years (range, 5.7-11.3 years), and the median 1-second forced expiratory volume was 95% of the predicted value. The median absolute eosinophil count in the peripheral blood was 0.48 x 109 /L and the ratio of total serum immunoglobulin E to the age-adjusted upper limit of the normal range was 2.7. Atopy, as defined by at least one positive response to skin prick testing, was found in 170 (83.3%) of the 204 patients. House dust mites were the most commonly sensitised aero-allergen (n=167; 81.9%). Sensitisation to food allergens was found in 47 (23.0%) of the patients. The self-reported frequency of asthmatic attacks was associated with a positive response to skin prick testing with animal allergens (P for trend = 0.001), whereas spirometric indices correlated with the degree of atopy and the presence of in vivo cockroach-specific immunoglobulin E ...
Buy OVA slgE elisa kit, Mouse Ovalbumin specific Immunoglobulin E ELISA Kit (MBS730660) product datasheet at MyBioSource, ELISA Kits
This test is done to check for allergies to specific allergens. Its especially useful in kids whove had life-threatening reactions to a certain allergen and for whom a skin-prick test would be too dangerous.
Suppression of IgE replies is a major goal for immunotherapy, especially in the field of allergy. even when they are not given until after starting HgCl2 administration. IFN- is definitely a pivotal cytokine in ameliorating the Th2 response and actions aimed at selective up-regulation of this cytokine may be of restorative value in suppression of undesirable IgE reactions. < 005 was taken to indicate statistical significance. RESULTS Exogenous type-1 cytokines suppress IgE production in HgCl2-treated BN rats HgCl2 treatment of BN rats resulted in designated elevation of serum IgE concentrations, as previously reported [7]. IgE levels were barely above normal at day time 7, then rose rapidly to maximum levels by day time 14. Administration of exogenous recombinant rat IFN- at a dose of 6 104 U/day time Motesanib had little effect (= 069, two-tailed MannCWhitney = 0009 HgCl2 only, = 001 group treated with 6 104 U/day time; two-tailed MannCWhitney = 0026). IgE levels at day time 14 were ...
The property of 109 CD4+ T cell clones (TCC) to induce IgE synthesis in vitro in human B cells was compared with their ability to produce IL-2, IL-4, and IFN-gamma in their supernatants (SUP) after 24-h stimulation with PHA. A significant positive correlation was found between the property of TCC to induce or enhance spontaneous IgE synthesis and their ability to release IL-4. In contrast, there was an inverse relationship between the IgE helper activity of TCC and their ability to release IFN-gamma, whereas no statistical correlation between the property to induce IgE synthesis and to produce IL-2 was observed. The ability of PHA-SUP from 71 CD4+ TCC to induce IgE synthesis in B cells was also investigated. Twenty-nine SUP (all derived from TCC active on IgE synthesis) induced production of substantial amounts of IgE in target B cells. There was a correlation between the amount of IgE synthesized by B cells in response to these SUP and their IL-4 content. An even higher correlation was found ...
HIV cannot be transmitted by rubbing against someone without more intimate sexual contact. IgE levels, by themselves, are not diagnostic of anything. However, high IgE levels are associated with...
Atopic diseases like asthma, atopic dermatitis and allergic rhinitis are complex traits of multifactorial origin. This study aimed to reveal gene-gene- and gene-environmental interactions of eight polymorphisms in five candidate genes. We examined whether 6 genetic variants of the genes coding for Interleukin-4 (IL-4), Interleukin-13 (IL-13) and their common receptor unit IL4R-alpha had genotypic effects on atopy-related traits such as total serum IgE levels in a large German birth cohort study (Multicenter Atopy Study, MAS 90) with longitudinally well defined phenotypes. Two single nucelotide polymorphisms (SNP) in the IL-13 gene (Arg130Gln, C-1055T) showed a significant association with increased serum IgE levels over the whole period of seven years. In addition, exposure to maternal smoking appears to modify the above effects on total serum IgE levels. We tested the association of atopy-related traits and a SNP of the complement factor 5 receptor (-245T) in the MAS cohort and in an ...
The effect of rat immunoglobulins and immune complexes on the locomotor function of rat polymorphonuclear leukocytes (PMN) was investigated in vitro. Rat immunoglobulin G1 (IgG1), IgG2a, IgG2b, and IgA monoclonal antibodies specific for the dinitrophenyl hapten were used. Both monomeric and polymeric IgA showed chemotactic activity in a dose-dependent manner. IgG1 and IgG2b also induced a dose-dependent locomotor response of PMN, but the nature of the induced migration was chemokinetic (enhancing random migration). IgG2a was chemotactic and induced maximal migration at a relatively low concentration. IgG1- and IgG2b-immune complexes induced stronger migration than antibody alone; however, IgA- and IgG2a-immune complexes did not. IgA was shown to modify the chemotactic movement of PMN induced by N-formylmethionyl-leucyl-phenylalanine (FMLP). In the presence of both IgA and FMLP in the lower chamber, the migration towards suboptimal concentrations of FMLP was enhanced. By contrast, IgA in the ...
Crystallographic and solution studies have shown that IgE molecules are acutely bent in their Fc region. cross-linking by allergen leads to cell degranulation, release of inflammatory mediators and an immediate allergic response. Disruption of the IgE-FcRI conversation is usually a validated strategy for therapeutic intervention in allergic diseases including asthma: an anti-IgE monoclonal IgG antibody, omalizumab (Xolair?, Novartis Pharmaceuticals Ltd), inhibits IgE binding to FcRI and is effective in the Tarafenacin treatment of severe persistent asthma and other allergic diseases2. IgE consists of a dimer of two identical heavy and two identical light chains, but unlike IgG in which the antigen-binding Fab region is separated from the receptor-binding Fc region by a flexible hinge, IgE contains an additional disulphide-linked pair of domains, (C2)2, forming a (C2-C3-C4)2 dimer1. Fluorescence depolarisation studies to assess segmental flexibility have shown IgE to be less flexible than IgG3-6, ...
If you need Allergy Positive Plasma or Off-The-Clot Serum for assay development, AbBaltis can help. Our samples are tested for multiple allergies using market-leading line blot tests as well as Phadia ImmunoCAP system.. Please find some of the examples of allergy positive plasma we can provide, or view specific products on the list underneath:. Food IgG Positive (Sensitivity). Multiple Specific IgE Positive. Inhalant IgE Positive. Food IgE Positive (Allergy). Insect Venom IgE Positive. Occupational IgE Positive. Antibiotic IgE Positive. ...
Allergic asthma may be associated with elevated IgE levels. Treatment for allergic asthma may include anti-IgE medications in addition to inhalers.
The main normal function of IgE (Immunoglobulin E) is believed to be in the protection against parasitic infestation. However, IgE is also associated with allergy and allergen-specific IgE antibodies may trigger allergic reactions in the presence of the proper allergen. IgE is normally found in low amounts in serum/plasma but is significantly increased in allergic individuals and the detection of allergen-specific IgE serves as the basis for many in vitro assays for specific diagnosis of allergy.. ...
COMMON DYSREGULATION AMONG ALLERGIC CONDITIONS. Allergic asthma, allergic rhinitis and atopic dermatitis are prevalent allergic diseases. These diseases can be distinguished by the location of their most important symptoms; lungs, sinuses and skin respectively.. They also share many characteristics, including the same underlying immune system dysregulation as evidenced by inappropriate T-cell mediated responses to innocuous antigens, peripheral eosinophilia, elevated serum IgE levels, chronic immune system activation, and over-production of inflammatory mediators, including leukotrienes, cytokines and chemokines.. LEUKOTRIENES AND INFLAMMATION IN ALLERGIC DISEASES. Leukotrienes are eicosanoid lipid mediators and are derived from the essential fatty acid arachidonic acid (AA), which is concentrated in the membrane phospholipids of cells of the immune system. The role of inflammatory mediators (leukotrienes) in allergic diseases is well characterized. In particular, leukotrienes play a significant ...
Anti-IgE antibodies react with the IgE isotype of human immunoglobulins. IgE is the shortest-lived immunoglobulin with a half-life of two days in serum. IgE plays an important role in allergy. It is especially associated with type 1 hypersensitivity, where IgE shows high-affinity binding to Fc receptors expressed on the surface of mast cells. Antigen binding to Fc receptor-bound IgE upon re-exposure to specific allergens results in degranulation and the release of a variety of mediators, such as histamine and cytokines. IgE has two main receptors: the high-affinity receptor FcεRI, which is expressed only on mast cells and basophils, and the low-affinity receptor FcεRII (CD23), which is expressed on B cells. - Belgique
Back in the Dark Ages, allergic people were probably much more likely to fight off intestinal parasites, viral and bacterial infections and even scourges like the Black Death. Up to 100 years ago, in fact, carrying genes that elicited a high IgE (Immunoglobulin E) response, was probably a distinct evolutionary advantage, something that kept the carriers of these genes more apt to survive to reproduce.. In our modern times, though, atopic individuals (those prone to allergies) find themselves fighting their own bodies or other otherwise harmless substances like peanuts, eggs, milk, nuts, fish, animal dander, dust, mould, grasses, pollens. Simple things can sometimes kill an allergic person. Those prone to allergies are often depicted as weak, mouth-breathing, nerdy, canary types whom others delight in kicking sand in their faces.. I come from a long line of allergic types. My grandfather on my fathers side died of an asthma attack in 1926. My father is anaphylactic to flat fish. My sister is ...
Background: To investigate the associations between clinical obstetric factors during birth and doctor-diagnosed wheezing and allergic sensitization during early childhood.. Methods: We followed 410 Finnish women from late pregnancy until 18 months age of their children. All children were delivered at term. Doctor-diagnosed wheezing among children was established by questionnaires, while specific immunoglobulin E antibodies to inhalant and food allergens were measured in 388 children at 1 year of age. Data on maternal obstetric variables were recorded at the time of delivery.. Results: Children of mothers with longer duration of ruptured fetal membranes before birth had significantly higher risk of doctor-diagnosed wheezing during early childhood compared to those children with shorter period of ruptured fetal membranes (III vs I quartile; aOR 6.65, 95% CI 1.99-22.18; P , 0.002 and IV vs I quartile; aOR 3.88, 95% CI 1.05-14.36, P , 0.043). Children who were born by Cesarean delivery had ...
During March 2016, a collaborative research agreement was signed with the aim of developing cell-processing products using the novel NKT ligand, RK, and carrying out nonclinical and clinical studies. The aim of this agreement is to develop the NKT cell-targeted cancer immunotherapy to obtain regulatory approval as Cellular and Tissue-based Product. During July 2017, a collaborative research agreement was signed with the aim of research and development NKT cell-targeted agent for allergic diseases. The research is on novel drugs for treating allergic diseases, with inhibition of immunoglobulin E production as the mechanism of action and reduction of clinical allergic symptoms accompanied. ...
TY - JOUR UR - http://lib.ugent.be/catalog/pug01:1242832 ID - pug01:1242832 LA - eng TI - Mucosal tissue polyclonal IgE is functional in response to allergen and SEB PY - 2011 JO - (2011) ALLERGY SN - 0105-4538 PB - 2011 AU - Zhang, Nan AU - Holtappels, Gabriële AU - Gevaert, Philippe GE19 001991295115 AU - Patou, Joke UGent 001997304566 870110659380 AU - Dhaliwal, B AU - Gould, Hannah AU - Bachert, Claus GE19 801001212658 0000-0003-4742-1665 AB - Staphylococcus aureus may modify airway disease by inducing local formation of polyclonal IgE antibodies (abs), the role of which is unknown. Methods: Nasal mucosal tissue and serum was obtained from 12 allergic rhinitis (AR) and 14 nasal polyp (NP) subjects. Skin prick tests were performed, and total and specific IgE abs to inhalant allergens and enterotoxin B were determined in serum and tissue. Tissue fragments were stimulated with anti-IgE, enterotoxin B, or grass and house dust mite allergens in different concentrations for 30 min. RBL SX38 cells ...
The immunoglobulin E (IgE) blood test is often done as part of an initial screen for allergies. High IgE levels also may indicate a parasitic infection.
Genetic polymorphisms of IL-18 and its receptor were reported to be associated with elevated serum IgE levels, atopy, and/or asthma. However, conflicting results were observed in various association studies and functional activity of these polymorphisms remains unclear. A total of 393 unrelated subjects were involved in this study. Direct PCR-sequencing method was used to screen novel polymorphisms. The functional significance of these polymorphisms was investigated using reporter gene assay. Three known (-137, +113, and +127) polymorphisms in the IL-18 promoter were identified with a perfect linkage disequilibrium (Δ = 1, p , 0.001) among them. No significant difference in the genotype frequencies of these polymorphisms between atopy and atopic phenotypes in Singaporean Chinese, Malays, and Indians was observed. However, transcriptional activities were significantly increased in HepG2 cultured cells with wild-type IL-18 genotype (-137/G, +113/T, and +127/C) than mutated genotype (-137/C, ...
Why the immune system mounts an attack against seemingly harmless agents baffles researchers. Because the immune system treats the harmless agent as a threat, B lymphocytes produce immunoglobulin E antibody (IgE). IgE attaches to mast cells such as those present in the nasal and bronchial passages, resulting in histamine release. Inflammation and allergy symptoms follow. Once sensitized, mast cells automatically release histamine when the invading agent reappears. Because IgE can sensitize cells anywhere in the body, individuals symptoms vary (eg, a cat may produce hives in one person and generate sneezing in another person).9,11 Allergy should not be confused with atopy. Atopy indicates that a person has developed a symptomless sensitization. The Increase in Allergies A genetic susceptibility to allergens has been established, but a shift in the human gene pool is an unlikely explanation for the increased prevalence of allergies. Shifts in population-based traits require several generations to ...
The purpose of this study was to evaluate the role of two major allergic pathways - IgE and non-IgE antibody mediated food allergy reaction (FAR) and lung inflammation disease using crustacean extracts. Although IgE antibody mediated food allergy reaction (IFAR) are defined as major mechanism in the past several decades, proteases from different sources acting similar to allergens as well as the long-term inflammatory stimulus through activation of protease activation receptors (PARs) are important. This opens new insight into non-IgE antibody mediated food allergy (NFAR) due to its dual effects. Therefore, it is necessary to investigate the interactions of these two pathways for a better understanding of the currently poor correlation between clinical symptoms and IgE specific diagnostics.. The current studies employed a humanized rat basophilic leukemia (RBL) cell line as well as a human lung epithelial cell line (A549) due to the presence of IgE receptors and PARs. Flow cytometric (FACS) and ...
Allergies, also known as allergic diseases, are a number of conditions caused by hypersensitivity of the immune system to something in the environment that usually causes little or no problem in most people. These diseases include hay fever, food allergies, atopic dermatitis, allergic asthma, and anaphylaxis. Symptoms may include red eyes, an itchy rash, sneezing, a runny nose, shortness of breath, or swelling. Food intolerances and food poisoning are separate conditions.. Common allergens include pollen and certain food. Metals and other substances may also cause problems. Food, insect stings, and medications are common causes of severe reactions. Their development is due to both genetic and environmental factors. The underlying mechanism involves immunoglobulin E antibodies (IgE), part of the bodys immune system, binding to an allergen and then to a receptor on mast cells or basophils where it triggers the release of inflammatory chemicals such as histamine. Diagnosis is typically based on a ...
When food proteins are injected in to the blood stream, a type I hypersensitivity reaction against an allergen, encountered for the first time, causes a response in a type of immune cell called a TH2 lymphocyte, which belongs to a subset of T cells that produce a cytokine called interleukin-4 (IL-4). These TH2 cells interact with other lymphocytes called B cells, whose role is the production of antibodies. Coupled with signals provided by IL-4, this interaction stimulates the B cell to begin production of a large amount of a particular type of antibody known as IgE that are specific to the food proteins. Secreted IgE circulates in the blood and binds to an IgE-specific receptor (a kind of Fc receptor called FcεRI) on the surface of other kinds of immune cells called mast cells and basophils, which are both involved in the acute inflammatory response. The IgE-coated cells, at this stage are sensitized to the allergen (food proteins). [1] [2] ...
Asthma is a common chronic disease worldwide and affects approximately 24 million persons in the United States. It is the most common chronic disease in childhood, affecting an estimated 7 million children.
CHO-Anti-Human IgE scFv stable cell line is clonally-derived from a CHO cell line, which has been transfected with an anti-human IgE scFv gene to allow expression of the scFv. It is an example of a cell line transfected using our proprietary CBTGS gene screening and amplification system.
Eczema can also increase your total IGE levels potentially affecting your blood test results. While it is not common, there have been cases where some individuals with extremely high scores to an allergen are not actually allergic. The high scores are due to high total IGE levels related in part to extreme eczema.. If you think you might not be allergic to an allergen or have accidentally ingested an allergen without reaction-you should discuss this with your allergist.. ...
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3 Serum-based technology History  1960, identification of human « reagin » as IgE  Preparation of IgE Fc fragment and production of polyclonal AB specific for the  heavy chain  1967, first total IgE and allergen-specific IgE RAST were developed (Wide, Lancet)  1974, first generation semi-quantitative IgE AB assay (birch specific IgE calibration curve and results expressed in classes) was first made commercially available by Pharmacia Laboratories.  Over the past decade there have been improvements in all aspects of technology with Second-generation quantitative IgE assays Third-generation automated IgE assays with a detection limit of 0.1 kU/L (Li CCA 2005) Biochip technology, microarrays (Wiltshire, Clin Chem 2000; Kim, Exp Mol Med 2002)
Concerning allergic diseases, the incidence of allergic symptoms, as well as their severity, seems to decrease with age. The decline of onset of allergic symptoms observed in ageing might result from a decrease of serum total and specific IgE. Atopic disorders are complex diseases that involve inter …
Principal Investigator:FUJITA Koichiro, Project Period (FY):1997 - 1998, Research Category:Grant-in-Aid for Scientific Research (C), Section:一般, Research Field:寄生虫学(含医用動物学)
Goat anti Mouse IgE antibody recognises the heavy chains of BALB/c mouse IgE. Goat anti Mouse IgE antibody has been cross adsorbed against
Immunoglobulin G[edit]. Hideo Matsumoto, professor emeritus at Osaka Medical College tested Gm types, genetic markers of ... Matsumoto, Hideo (2009). "The origin of the Japanese race based on genetic markers of immunoglobulin G.". Proceedings of the ... immunoglobulin G, of Khmer people for a 2009 study.[33] The study found that the Gm afb1b3 is a southern marker gene possibly ...
Intravenous immunoglobulins (IVIGs). Intravenous immunoglobulins may be used to control SLE with organ involvement, or ... "Intravenous Immunoglobulins (IVIGs) in Lupus Central Station, sourced from the National Institute of Arthritis and ... Direct immunofluorescence can detect deposits of immunoglobulins and complement proteins in the people's skin. When skin not ...
Human immunoglobulins[edit]. *Rho(D) immune globulin (anti-D immunoglobulin). *Anti-rabies immunoglobulin ...
Scheinfeld, Noah (2019-08-05). "Intravenous Immunoglobulin". Intravenous Immunoglobulin. Medscape. Perumbeti, Ajay (2018-08-06 ...
The structure of immunoglobulin polypeptide chain is dictated and controlled by number of genes encoded in the germ line. ... Immunoglobulin+allotypes at the US National Library of Medicine Medical Subject Headings (MeSH) Overview at University of South ... However, it is important to mention that not all variations in immunoglobulin amino acid sequence pose as a determinant ... Mage R, Lieberman R, Potter M, Terry WD (January 1973). "Immunoglobulin Allotypes". The Antigens. Academic Press. pp. 299-376. ...
The mutation rate in antigen-binding coding sequences of the immunoglobulin genes is up to 1,000,000 times higher than in cell ... Teng, Grace; Papavasiliou, F. Nina (2007). "Immunoglobulin Somatic Hypermutation". Annual Review of Genetics. 41 (1): 107-120. ...
IV immunoglobulin only). However, long-term remission without the use of cytotoxic and immune-suppressive therapies is unlikely ... Intravenous immunoglobulin is also used. Methotrexate and vincristine have also been used. Other medications include cytokine ...
Each immunoglobulin domain has a similar structure, characteristic of all the members of the immunoglobulin superfamily: it is ... Somatic recombination of immunoglobulins, also known as V(D)J recombination, involves the generation of a unique immunoglobulin ... The membrane-bound form of an antibody may be called a surface immunoglobulin (sIg) or a membrane immunoglobulin (mIg). It is ... Antibodies are glycoproteins belonging to the immunoglobulin superfamily. The terms antibody and immunoglobulin are often used ...
Immunoglobulin+somatic+hypermutation at the US National Library of Medicine Medical Subject Headings (MeSH). ... During B cell division the immunoglobulin variable region DNA is transcribed and translated. The introduction of mutations in ... Affinity maturation Anergy Immune system V(D)J recombination Immunoglobulin class switching Janeway, C.A.; Travers, P.; Walport ... This directed hypermutation allows for the selection of B cells that express immunoglobulin receptors possessing an enhanced ...
House agrees with both Adams, orders treatment for GAD; steroids and immunoglobulin. Park follows House and tells him that ...
"Entrez Gene: IGHG4 immunoglobulin heavy constant gamma 4 (G4m marker)". CS1 maint: discouraged parameter (link) McLean GR, ... Hisajima H, Nishida Y, Nakai S, Takahashi N, Ueda S, Honjo T (May 1983). "Structure of the human immunoglobulin C epsilon 2 ... Ellison J, Buxbaum J, Hood L (1983). "Nucleotide sequence of a human immunoglobulin C gamma 4 gene". DNA. 1 (1): 11-8. doi: ... Ueda S, Nakai S, Nishida Y, Hisajima H, Honjo T (1984). "Long terminal repeat-like elements flank a human immunoglobulin ...
... primarily occurs on surface immunoglobulin of germinal center B cells and as a direct result of somatic ... Teng, G.; Papavasiliou, F.N. (2007). "Immunoglobulin Somatic Hypermutation". Annu. Rev. Genet. 41: 107-120. doi:10.1146/annurev ... of the immunoglobulin genes. The mutation rate is up to 1,000,000 times higher than in cell lines outside the lymphoid system. ...
Immunoglobulin+Isotypes at the US National Library of Medicine Medical Subject Headings (MeSH) Overview at University of South ... In immunology, antibodies (immunoglobulins (Ig)) are classified into several types called isotypes or classes. The variable (V ... Stavnezer, Janet (1996). "Immunoglobulin Class Switching". Current Opinion in Immunology. 8 (2): 199-205. doi:10.1016/s0952- ... Wahren, B., Linde, G. A. (1983). "Virus-specific antibody activity of different subclasses of immunoglobulins G and A in ...
Other classes of immunoglobulins such as IgM and IgA are present in approximately 20% of cases and usually are less intense. In ... Czernik A, Toosi S, Bystryn JC, Grando SA (February 2012). "Intravenous immunoglobulin in the treatment of autoimmune bullous ... Anti-inflammatory drugs 3. Biologic therapy i. Intravenous immunoglobulin ii. Rituximab Among all, topical or systemic ... For refractory disease, biologic therapies such as intravenous immunoglobulin and Rituximab should be considered. [1,19,20] ...
Rabbitts, T. H. (1983). "The human immunoglobulin genes. The nineteenth Colworth medal lecture". Biochemical Society ...
... leukocyte immunoglobulin-like receptor; ILT: immunoglobulin-like transcript; LIR: leukocyte inhibitory receptor; MIR: ...
FOXP3 Immunoglobulin A deficiency 2; 609529; TNFRSF13B Inclusion body myopathy with early-onset Paget disease and ...
Lesk and Chothia also studied the conformations of antigen-binding sites of immunoglobulins. They discovered the "canonical- ... "Conformations of immunoglobulin hypervariable regions". Nature. 342 (6252): 877-883. Bibcode:1989Natur.342..877C. doi:10.1038/ ...
... immunoglobulin A proteinase) is an enzyme. This enzyme catalyses the following chemical reaction Cleavage of immunoglobulin A ... Immunoglobulin A Plaut AG (1983). "The IgA1 proteases of pathogenic bacteria". Annual Review of Microbiology. 37 (1): 603-22. ... The natural substrate of IgA proteases is immunoglobulin A, hence its name. The enzyme is in fact capable of cleavage of ... Qiu J, Brackee GP, Plaut AG (March 1996). "Analysis of the specificity of bacterial immunoglobulin A (IgA) proteases by a ...
"IGH immunoglobulin heavy locus (human )". Entrez Gene. "TTL tubulin tyrosine ligase (human)". Entrez Gene. "CHIC2 cysteine rich ... Immunoglobulin heavy chain gene IGH; g) enzyme genes TTL (adds and removes tyrosine residues on α-tubulin), GOT1 (an Aspartate ...
Akdamar, K; Epps, AC; Maumus, LT; Sparks, RD (25 May 1972). "Immunoglobulin changes in liver disease". Annals of the New York ...
Papavasiliou, F.Nina; Schatz, David G (April 2002). "Somatic Hypermutation of Immunoglobulin Genes". Cell. 109 (2): S35-S44. ... "Control of immunoglobulin gene rearrangements in developing B cells". Current Opinion in Immunology. 9 (2): 233-238. doi: ... "Cell-cycle-regulated DNA double-strand breaks in somatic hypermutation of immunoglobulin genes". Nature. 408 (6809): 216-221. ...
"Entrez Gene: IGJ immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides". Kiyono, Hiroshi; ... As part of a polymeric immunoglobulin (pIg), the J-chain is essential for binding of pIg to the pIgR, which forms the secretory ... It exhibits a standard immunoglobulin folding structure of two β-pleated sheets of four ribbons folded against one another. It ... Koshland ME (1986). "The coming of age of the immunoglobulin J chain". Annu. Rev. Immunol. 3: 425-53. doi:10.1146/annurev.iy. ...
Omalizumab inhibits human immunoglobulin E (IgE) and is useful in moderate-to-severe allergic asthma. Alzheimer's disease (AD) ... Jefferis R, Lefranc MP (July-August 2009). "Human immunoglobulin allotypes: possible implications for immunogenicity". mAbs. 1 ... Immunoglobulin G (IgG) antibodies are large heterodimeric molecules, approximately 150 kDa and are composed of two kinds of ... "Conformations of immunoglobulin hypervariable regions". Nature. 342 (6252): 877-83. Bibcode:1989Natur.342..877C. doi:10.1038/ ...
de Bono, B. (2003). "Exegesis: a procedure to improve gene predictions and its use to find immunoglobulin superfamily proteins ... CS1 maint: discouraged parameter (link) Bateman, A; Eddy, S. R.; Chothia, C (1996). "Members of the immunoglobulin superfamily ... CS1 maint: discouraged parameter (link) Al-Lazikani, Bissan (1999). Canonical structures of immunoglobulins and T cell ... de Bono, Bernard (2004). Immunoglobulin superfamily proteins in human and mouse (PhD thesis). University of Cambridge. ...
"Conformations of immunoglobulin hypervariable regions". Nature. 342 (6252): 877-883. Bibcode:1989Natur.342..877C. doi:10.1038/ ...
"Conformations of immunoglobulin hypervariable regions". Nature. 342 (6252): 877-883. Bibcode:1989Natur.342..877C. doi:10.1038/ ...
The main symptom is increased level of eosinophils in the blood, but elevated immunoglobulin E (IgE) levels may also be present ... Some patients require immunoglobulin treatment. Allenspach E, Torgerson TR (May 2016). "Autoimmunity and Primary ...
Rogozin IB, Kolchanov NA (November 1992). "Somatic hypermutagenesis in immunoglobulin genes. II. Influence of neighbouring base ...
Harboe, M. (1972). "Nobel prize for immunoglobulin research". Tidsskrift for den Norske Laegeforening. 92 (34): 2363-2365. PMID ... Porter-the 4-chain structure of immunoglobulin G". Mayo Clin. Proc. 75 (11): 1110. doi:10.4065/75.11.1110. PMID 11075737. " ...
Antibodies (also called immunoglobulins) are proteins the immune system makes to recognize and get rid of germs. ... An IgA test measures the blood level of immunoglobulin A, one of the most common types of antibodies in the body. ...
Immunoglobulin E (IgE) is a type of antibody (or immunoglobulin (Ig) "isotype") that has only been found in mammals. IgE is ... Presence of a unique immunoglobulin as a carrier of reaginic activity". J. Immunol. 97 (1): 75-85. PMID 4162440.. ... Winter WE, Hardt NS, Fuhrman S (2000). "Immunoglobulin E: importance in parasitic infections and hypersensitivity responses". ... Johansson SG, Bennich H. Immunological studies of an atypical (myeloma) immunoglobulin. Immunology 1967; 13:381-94. ...
Immunoglobulin therapy, also known as normal human immunoglobulin (NHIG), is the use of a mixture of antibodies ( ... Some believe that immunoglobulin therapy may work via a multi-step model where the injected immunoglobulin first forms a type ... Although immunoglobulin is frequently used for long periods of time and is generally considered safe, immunoglobulin therapy ... an immunoglobulin infusion may pass a virus to its recipient.[16] Some immunoglobulin solutions also contain isohemagglutinins ...
... one of the most common immunoglobulins, it is mainly present in body secretions and is the chief antibody in the mucous ... One of the five classes of immunoglobulins; one of the most common immunoglobulins, it is mainly present in body secretions and ... One of the five classes of immunoglobulins; ... Immunoglobulins (IgA, IgG, IgM) * Immunophenotyping by Flow ...
One of the five classes of immunoglobulins; it is present in small amounts in serum and is thought to function in certain ... One of the five classes of immunoglobulins; it is present in small amounts in serum and is thought to function in certain ...
The International Symposium on the Immunoglobulin A System was organized in observance of the twenty-fifth anni- versary of the ... Immunoglobulin A was chosen as the sub- ject of the Symposium because of its broad scope in relation to all biologic sciences, ... antibody antigen bacteria dentistry genetics immune system immunity immunization immunoglobulin infection planning prevention ... The International Symposium on the Immunoglobulin A System was organized in observance of the twenty-fifth anni- versary of the ...
An IgA test measures the blood level of immunoglobulin A, one of the most common antibodies in the body. Antibodies are ...
The plasma cells switch from producing IgM to IgG or to another immunoglobulin class. The switch involves a change in the H ... The genes coding for these diverse range of immunoglobulins however are limited and do not number similar to the variety of ... The variable region of each immunoglobulin heavy or light chain is encoded in several pieces on the genes. These are called ... This process results in an immunoglobulin gene that encodes an antibody of a different isotype. ...
Immunoglobulin E (IgE) is a type of protein in the body called an antibody. ... Immunoglobulin E (IgE). Immunoglobulin E (IgE) is a type of protein in the body called an antibody. As part of the immune ...
Immunoglobulin genes. [T Honjo; Frederick W Alt; T H Rabbitts;] -- Immunoglobin Genes is the first comprehensive book on the ... Immunoglobulin a schema:Intangible ;. schema:name "Genes, Immunoglobulin"@en ;. . ... Immunoglobulin genes. Author:. T Honjo; Frederick W Alt; T H Rabbitts. Publisher:. London ; San Diego : Academic Press, ©1989. ... Immunoglobulin genes/T Honjo; Frederick W Alt; T H Rabbitts;; London ; San Diego : Academic Press, ©1989. ...
Immunoglobulin (IgE). Many people have allergy-induced asthma, which means that their asthma symptoms are triggered by allergic ... These people have high levels of an allergy-causing antibody (a type of immune protein in the body) called immunoglobulin E ( ...
Immunoglobulin A (IgA) nephropathy is characterized by predominant IgA deposition in the glomerular mesangium.{ref1} It is one ... What is immunoglobulin A (IgA) nephropathy?. Updated: Feb 15, 2018 * Author: Sohail Abdul Salim, MD, FASN, FACP; Chief Editor: ... Immunoglobulin A (IgA) nephropathy is characterized by predominant IgA deposition in the glomerular mesangium. [1] It is one of ... Guideline] Chapter 10: Immunoglobulin A nephropathy. Kidney Int Suppl (2011). 2012 Jun. 2 (2):209-217. [Medline]. [Full Text]. ...
Immunoglobulin G (IgG) holds the highest share (44%) in the global blood plasma market, with a revenue of $9.24 billion. ... Immunoglobulin (Ig) therapies are among the oldest therapeutic moieties employed in a broad range of pathological conditions. ... Immunoglobulin G (IgG) holds the highest share (44%) in the global blood plasma market, with a revenue of $9.24 billion. ... Immunoglobulin (Ig) therapies are among the oldest therapeutic moieties employed in a broad range of pathological conditions. ...
... immunoglobulin deficiency - Answer: Most people with selective IgA (immunoglobulin) deficiency have no ... ... Home › Q & A › Questions › Immunoglobulin Deficiency -.... Immunoglobulin Deficiency - symptoms of deficiency?. Asked. 29 Nov ... Immunoglobulin Deficiency - Is ivig safe and how long do I have to use it?. Posted 23 Oct 2011 • 2 answers ... Most people with selective IgA (immunoglobulin) deficiency have no symptoms.. Some people with this condition have chronic ...
FRANGIONE, B., MILSTEIN, C. & FRANKLIN, E. Immunoglobulins: Chemical Typing of Immunoglobulins. Nature 221, 149-151 (1969). ...
For health professionals : Refer a patient : Laboratory Services : Test Table : Immunoglobulin-G, Serum ...
... Semi-Quantitative Bioassay Quantitative Chemiluminescent Immunoassay Send Out. Negative or ...
Antenatal prophylaxis with anti-D immunoglobulin. BMJ 1989; 299 doi: https://doi.org/10.1136/bmj.299.6704.920 (Published 07 ...
Antenatal prophylaxis with anti-D immunoglobulin British Medical Journal 1989; 299 :920 ... Antenatal prophylaxis with anti-D immunoglobulin. British Medical Journal 1989; 299 doi: https://doi.org/10.1136/bmj.299.6704. ...
The structure of immunoglobulin superfamily domains 1 and 2 of MAdCAM-1 reveals novel features important for integrin ... The structure of immunoglobulin superfamily domains 1 and 2 of MAdCAM-1 reveals novel features important for integrin ... MAdCAM-1 belongs to a subclass of the immunoglobulin superfamily (IgSF), the members of which are ligands for integrins [PMID: ... 9655832]. The crystal structure of this domain has been reported; it adopts an immunoglobulin-like beta-sandwich structure, ...
IgG stands for immunoglobulin G, a type of antibody. Antibodies are proteins made by the immune system to fight viruses, ... URL of this page: https://medlineplus.gov/lab-tests/csf-immunoglobulin-g-igg-index/ CSF Immunoglobulin G (IgG) Index. ... Other names: cerebrospinal fluid IgG level, cerebrospinal fluid IgG measurement, CSF IgG level, IgG (Immunoglobulin G) spinal ... www.uwhealth.org/health/topic/medicaltest/immunoglobulins/hw41342.html#hw41354 ...
... deficiency is a defect of humoral immunity that is characterized by abnormally low serum levels of IgD immunoglobulins. Little ... encoded search term (Immunoglobulin%20D%20Deficiency) and Immunoglobulin D Deficiency What to Read Next on Medscape. Medscape ... Immunoglobulin D Deficiency. Updated: Sep 13, 2016 * Author: Camellia L Hernandez, MD; Chief Editor: Michael A Kaliner, MD more ... Immunoglobulin D (IgD) deficiency is a defect of humoral immunity that is characterized by abnormally low serum levels of IgD ...
IVIG combines immunoglobulin from the blood of many people to boost, this is used to boost the patients immune system to fight ... About Intravenous Immunoglobulin (IVIG) What is immunoglobulin?. An immunoglobulin is also known as an antibody. It is a ... Immunoglobulin can be collected from the plasma of donated blood. It takes the plasma from thousands of people to make a dose ... There are some immunoglobulin products that are given by an injection into the muscle (called IM) or under the skin (called ...
Make research projects and school reports about immunoglobulin easy with credible articles from our FREE, online encyclopedia ... The main immunoglobulin of blood, lymph, and tissue fluid is immunoglobulin G (IgG). It binds to microorganisms, promoting ... immunoglobulin Protein found in the blood that plays a role in the immune system. Immunoglobulins act as antibodies for ... immunoglobulin An antibody secreted by B cells.. Cite this article Pick a style below, and copy the text for your bibliography ...
Total immunoglobulin A deficiency (IgAD) is defined as an undetectable serum immunoglobulin A (IgA) level at a value < 5 mg/dL ... Selective immunoglobulin A deficiency (SIgAD) is a primary immunodeficiency disease and is the most common of the primary ... encoded search term (Immunoglobulin A Deficiency) and Immunoglobulin A Deficiency What to Read Next on Medscape. Related ... Immunoglobulin A Deficiency Medication. Updated: May 15, 2018 * Author: Marina Y Dolina, MD; Chief Editor: Michael A Kaliner, ...
An immunoglobulin light chain protein was isolated from the urine of an individual (BRE) with systemic amyloidosis. Complete ... An immunoglobulin light chain protein was isolated from the urine of an individual (BRE) with systemic amyloidosis. Complete ... Tertiary structure of an amyloid immunoglobulin light chain protein: a proposed model for amyloid fibril formation.. Schormann ...
An immunoglobulins test measures the levels of certain antibodies in your blood. Abnormal levels can indicate a serious health ... What is an immunoglobulins blood test?. This test measures the amount of immunoglobulins, also known as antibodies, in your ... An immunoglobulins test usually measures three specific types of immunoglobulins. They are called igG, igM, and IgA. If your ... Why do I need an immunoglobulins blood test?. You may need this test if your health care provider thinks your immunoglobulin ...
Immunoglobulin G, Qn, Serum. 2465-3. 001776. Immunoglobulin G, Qn, Serum. mg/dL. 2465-3. ... Immunoglobulin G is the major antibody containing protein fraction of blood. With significant decreases in IgG level, on either ... patients with repeated infection should have their immunoglobulins, and specifically IgG, measured. Therapy with exogenous γ- ...
Immunoglobulin D, Quant, Serum. 2460-4. 002178. Immunoglobulin D, Quant, Serum. mg/dL. 2460-4. ...
The definition of immunoglobulin is a protein that fights against disease. (noun) An example of an immunoglobulin is a protein ... The definition of immunoglobulin is a protein that fights against disease.. An example of an immunoglobulin is a protein that ... immunoglobulin. noun. Abbr. Ig *Any of a group of large glycoproteins, including all the antibodies that function in the ... plural immunoglobulins). *(biochemistry, immunology) Any of the glycoproteins in blood serum that respond to invasion by ...
  • Immunoglobulin E ( IgE ) is a type of antibody (or immunoglobulin (Ig) " isotype ") that has only been found in mammals . (wikipedia.org)
  • one of the most common immunoglobulins, it is mainly present in body secretions and is the chief antibody in the mucous membranes of the gastrointestinal and respiratory tract and in saliva and tears. (labtestsonline.org)
  • This process results in an immunoglobulin gene that encodes an antibody of a different isotype. (news-medical.net)
  • Retrieved on May 22, 2019 from https://www.news-medical.net/health/Antibody-Immunoglobulin-Diversity.aspx. (news-medical.net)
  • Immunoglobulin E (IgE) is a type of protein in the body called an antibody. (kidshealth.org)
  • These people have high levels of an allergy-causing antibody (a type of immune protein in the body) called immunoglobulin E (IgE). (kidshealth.org)
  • IgG stands for immunoglobulin G, a type of antibody. (medlineplus.gov)
  • An immunoglobulin is also known as an antibody. (oncolink.org)
  • Immunoglobulin M ( IgM ) is the first antibody to be produced following immunization or infection. (encyclopedia.com)
  • Immunoglobulin D ( IgD ) is present in serum in very low concentrations, but occurs on the surface of antibody-secreting B cells, whose activity it may regulate. (encyclopedia.com)
  • Anti-D immunoglobulin treatment for thrombocytopenia associated with primary antibody deficiency. (medscape.com)
  • Immunoglobulin G is the major antibody containing protein fraction of blood. (labcorp.com)
  • Immunoglobulin A ( IgA , also referred to as sIgA in its secretory form) is an antibody that plays a crucial role in the immune function of mucous membranes . (wikipedia.org)
  • Immunoglobulin M (IgM) is one of several isotypes of antibody (also known as immunoglobulin) that are produced by vertebrates. (wikipedia.org)
  • Immunoglobulin, abbreviated at Ig, is also referred to as antibody. (wisegeek.com)
  • Immunoglobulin M , or IgM for short, is a basic antibody that is present on B cells . (bionity.com)
  • It is also the first immunoglobulin expressed in the fetus (around 20 weeks) and also phylogenetically the earliest antibody to develop. (bionity.com)
  • An antibody , also known as an immunoglobulin , is a large Y-shaped protein used by the immune system to identify and neutralize foreign objects such as bacteria and viruses. (phys.org)
  • the terms antibody and immunoglobulin are often used interchangeably. (phys.org)
  • The gut characteristically produces gram quantities of immunoglobulin A (IgA) antibody, which is presumed to protect the gut from pathogen attack. (sciencemag.org)
  • 9. The composition of claim 1, wherein said immunoglobulins exhibit increased antibody-dependent cellular cytotoxicity (ADCC) activity. (freepatentsonline.com)
  • 17. The pharmaceutical composition of claim 14, wherein said immunoglobulins comprise an antibody which binds to an antigen selected from the group consisting of growth factors, FGFR, EGFR, VEGF, leukocyte antigens, CD20, CD33, cytokines, TNF-α and TNF-β. (freepatentsonline.com)
  • Immunoglobulin is a blood/plasma product, which is prepared from the serum of multiple of donors, used to treat patients with antibody deficiency. (medgadget.com)
  • Prevalence of various antibody deficiency disorders such as common variable immune deficiency (CVID), specific antibody deficiency, and hypogammaglobulinemia, increase in immunoglobulin indications, improved production & purification processes, growth in awareness towards antibody deficiency, and rare immune disorders among patient population drive the growth of the Immunoglobulin market. (medgadget.com)
  • A monoclonal anti-immunoglobulin E antibody used in the treatment of severe asthma and chronic idiopathic urticaria. (drugbank.ca)
  • Immunoglobulin D ( IgD ) is an antibody isotype that makes up about 1% of proteins in the plasma membranes of immature B-lymphocytes where it is usually coexpressed with another cell surface antibody called IgM . (wikidoc.org)
  • Allergic (extrinsic) asthma is associated with immunoglobulin E (IgE)-an antibody generated by the immune system, in this case, in response to a normally harmless substance. (verywellhealth.com)
  • An IgA test measures the blood level of immunoglobulin A, one of the most common types of antibodies in the body. (kidshealth.org)
  • Antibodies (also called immunoglobulins) are proteins the immune system makes to recognize and get rid of germs . (kidshealth.org)
  • Immunoglobulin therapy , also known as normal human immunoglobulin ( NHIG ), is the use of a mixture of antibodies (immunoglobulins) to treat a number of health conditions. (wikipedia.org)
  • The genes coding for these diverse range of immunoglobulins however are limited and do not number similar to the variety of antibodies. (news-medical.net)
  • immunoglobulin One of a group of proteins ( globulins ) in the body that act as antibodies . (encyclopedia.com)
  • This test measures the amount of immunoglobulins, also known as antibodies, in your blood. (medlineplus.gov)
  • Immunoglobulin G antibodies are the only antibodies that pass from mother to fetus through the placenta. (thefreedictionary.com)
  • Elevated immunoglobulin levels mean that the body's immune system has produced antibodies in response to a threat, such as bacteria, viruses, fungus, animal dander or cancer cells. (reference.com)
  • Immunoglobulins, also known as antibodies, attach themselves to foreign objects so that the immune system can destroy them, notes WebMD. (reference.com)
  • Produced by the body's immune system, antibodies, also known as immunoglobulins, are Y-shaped proteins that help identify and remove antigens and other for. (reference.com)
  • amysamp - I see your thinking, that you may need to replenish the IgA if it is high and therefore chronically fighting the infection therefore you might need new immunoglobulin antibodies to continue the fight. (wisegeek.com)
  • How great are these immunoglobulin antibodies? (wisegeek.com)
  • Here, we describe a method for rapid and consistent global characterization of leachable metal- or peroxide-stressed immunoglobulin (lg) G1 monoclonal antibodies (mAbs). (genengnews.com)
  • An immunoglobulins test is done to measure the level of immunoglobulins, also known as antibodies , in your blood. (cigna.com)
  • PhysOrg.com) -- Like a blood-borne army, immunoglobulin G belongs to a class of antibodies that binds to viruses, fungi, bacteria and other foreign particles to initiate their destruction. (phys.org)
  • Immunoglobulins are commonly known as antibodies . (chegg.com)
  • Immunoglobulin A is one class of a group of immunoglobulin proteins known as antibodies. (embracepetinsurance.com)
  • IgA (shorthand for Immunoglobulin A) is a class of antibodies that works to protect the surfaces of the body from the most immediate, superficial kind of invaders. (embracepetinsurance.com)
  • Stimulation of resting B lymphocytes with antibodies to surface immunoglobulin (sIgD or sIgM) induces protein tyrosine phosphorylation, implicating one or more B-cell protein-tyrosine kinases (PTKs) in sIg signal transduction. (pnas.org)
  • When you are given an immunoglobulin, your body uses antibodies from other people's blood plasma to help prevent illness. (wellspan.org)
  • Treatments for some cancers can cause the body to stop producing its own antibodies, making immunoglobulin treatment necessary. (wellspan.org)
  • Zoster Immunoglobulin-VF contains protein substances called antibodies which can provide protection against the virus causing chickenpox and shingles. (nps.org.au)
  • Immunoglobulin Deficiency - Is ivig safe and how long do I have to use it? (drugs.com)
  • IVIG (Intravenous immunoglobulin)? (drugs.com)
  • OKLAHOMA CITY , Sept. 12, 2018 /PRNewswire/ -- A subset of children with autism spectrum disorder (ASD), who have an immune abnormality, may benefit from intravenous immunoglobulin (IVIg) treatment, according to new research from Richard E. Frye , MD, PhD, Chief of Neurodevelopmental Disorders at the Barrow Neurological Institute at Phoenix Children's Hospital. (prnewswire.com)
  • Intravenous immunoglobulin (IVIg) is beneficial in other autoimmune diseases. (nih.gov)
  • To review the literature on the use and efficacy of intravenous immunoglobulin (IVIG) in glomerulonephritis and to evaluate the nephrotoxic effect of IVIG. (nih.gov)
  • What are the "off-label" uses of intravenous immunoglobulin (IVIG) in neurology? (medscape.com)
  • To determine whether high-dose intravenous immunoglobulin (IVIg) is more effective than placebo in restoring lost visual function (visual acuity) in optic neuritis (ON). (clinicaltrials.gov)
  • The TGA has become aware of reports of a markedly increased incidence of serious adverse reactions associated with Octagam, an intravenous immunoglobulin (IVIg) preparation, manufactured by Octapharma in Europe. (tga.gov.au)
  • Brooklyn, NY -- ( SBWIRE ) -- 11/01/2017 -- QYResearchReports.com has announced the addition of a report titled, "Global Intravenous Immunoglobulin (IVIg) Market Research Report 2017" to its depository. (sbwire.com)
  • The improvement in the production of IVIg on account of technological advancements is another key catalyst of the market for intravenous immunoglobulin. (sbwire.com)
  • The exorbitant costs of IVIg technology might also emerge as another restraint of the market for intravenous immunoglobulin. (sbwire.com)
  • A preparation containing immunoglobulin proteins, especially immune globulin. (yourdictionary.com)
  • The new vaccine worked well whether it contained interleukin-2 and immunoglobulin G proteins or the genes encoding these proteins. (thefreedictionary.com)
  • Proteins in this superfamily contain varying numbers of immunoglobulin-like domains and are thought to participate in the regulation of interactions between cells. (nih.gov)
  • The immunoglobulin superfamily is a group of proteins, each made of one or several domains sharing key structural features with either the variable (V) or the constant (C) immunoglobulin domains. (nih.gov)
  • A purified form of human immunoglobulin G and other proteins used to treat immunodeficiency and a wide variety of autoimmune disorders. (drugbank.ca)
  • The variable region of each immunoglobulin heavy or light chain is encoded in several pieces on the genes. (news-medical.net)
  • More recently, expression of engineered immunoglobulin genes in tissue culture can be used to produce IgM with specific alternations and thus to identify the molecular requirements for features of interest. (wikipedia.org)
  • The technique should also lead to the cloning of antigen-binding specificities directly from immunoglobulin genes. (pnas.org)
  • Predicting the onset of AL is highly challenging, as each patient carries a different pathogenic LC sequence resulting from a unique rearrangement of variable (V) and joining (J) immunoglobulin genes and a unique set of somatic mutations (SMs) acquired during B cell affinity maturation 9 (Fig. 1a ). (nature.com)
  • The bovine x mouse hybrid cells can be expected to provide bovine monoclonal immunoglobulins for sequencing studies and for use as serological standards as well as to provide messenger RNA for cloning bovine immunoglobulin genes. (sciencemag.org)
  • An immunoglobulin light chain protein was isolated from the urine of an individual (BRE) with systemic amyloidosis. (rcsb.org)
  • The definition of immunoglobulin is a protein that fights against disease. (yourdictionary.com)
  • An example of an immunoglobulin is a protein that fights against strep throat. (yourdictionary.com)
  • Immunoglobulin is a type of protein that helps the body fight disease. (wisegeek.com)
  • In screening mouse cytolytic-T-cell-derived cDNA libraries, we came across cDNA clones defining a sequence, CTLA-4, which could encode a 223-amino-acid protein clearly belonging to the immunoglobulin superfamily. (nih.gov)
  • Immunoglobulins are made of four protein chains. (chegg.com)
  • Anti-immunoglobulin stimulation of B lymphocytes activates src-related protein-tyrosine kinases. (pnas.org)
  • Immunoglobulin (also called gamma globulin or immune globulin) is a substance made from human blood plasma. (wellspan.org)
  • Each immunoglobulin molecules is a tetramer of two identical light chains and two identical heavy chains linked by disulfide bonds. (uniprot.org)
  • Immunoglobulins include light chains and heavy chains. (wikipedia.org)
  • Because of the less-than-robust response to therapy and impact on choice of optimal chemotherapy and prognosis, chronic kidney disease has drawn attention in the treatment of multiple myeloma, a malignant hematologic disorder that can produce significant amounts of monoclonal immunoglobulin free light chains (FLCs). (jci.org)
  • Serological levels of free immunoglobulin light chains (FLCs), produced in excess of heavy chains during synthesis of immunoglobulins by plasma cells, can be considered a direct marker of B cell activity in different systemic inflammatory-autoimmune conditions and may represent a useful predictor of rituximab (RTX) therapeutic efficacy, as reported for rheumatoid arthritis and systemic lupus erythematosus. (hindawi.com)
  • In systemic light chain amyloidosis (AL), pathogenic monoclonal immunoglobulin light chains (LC) form toxic aggregates and amyloid fibrils in target organs. (nature.com)
  • Systemic light-chain amyloidosis (AL) is a monoclonal gammopathy characterized by the abnormal proliferation of a plasma cell clone producing large amounts of pathogenic immunoglobulin free light chains (LCs) 1 . (nature.com)
  • Structural elements of immunoglobulin light chains are depicted on top of the sequences (FR1 = framework 1, CDR1 = complementary determining region 1, FR2 = framework 2, CDR2 = complementary determining region 2, FR3 = framework 3, CDR3 = complementary determining region 3, FR4 = framework 4). (nature.com)
  • Structural elements of immunoglobulin light chains are shown on the left. (nature.com)
  • They are comprised of two heavy (IMMUNOGLOBULIN HEAVY CHAINS) and two light chains (IMMUNOGLOBULIN LIGHT CHAINS) with additional ancillary polypeptide chains depending on their isoforms. (drugbank.ca)
  • Favorable Outcome of Severe, Extensive, Granulocyte Colony-Stimulating Factor-Induced, Corticosteroid-Resistant Sweet's Syndrome Treated With High-Dose Intravenous Immunoglobulin. (medscape.com)
  • Immunoglobulin Deficiency - symptoms of deficiency? (drugs.com)
  • Most people with selective IgA (immunoglobulin) deficiency have no symptoms. (drugs.com)
  • Immunoglobulin D (IgD) deficiency is a defect of humoral immunity that is characterized by abnormally low serum levels of IgD immunoglobulins. (medscape.com)
  • Immunoglobulin A deficiency (IgAD) has no specific treatment. (medscape.com)
  • Favre O, Leimgruber A, Nicole A, Spertini F. Intravenous immunoglobulin replacement prevents severe and lower respiratory tract infections, but not upper respiratory tract and non-respiratory infections in common variable immune deficiency. (medscape.com)
  • Immunoglobulin A Deficiency is a topic covered in the Select 5-Minute Pediatrics Topics . (unboundmedicine.com)
  • 5minute , www.unboundmedicine.com/5minute/view/Select-5-Minute-Pediatric-Consult/14162/all/Immunoglobulin_A_Deficiency. (unboundmedicine.com)
  • When IgA is determined to be deficient in dogs, the condition may be diagnosed as "selective immunoglobulin A deficiency. (embracepetinsurance.com)
  • The immunoglobulin market size accounted for $9,972.9 million in 2017, and is projected to reach $16,694.7 million by 2025, registering a CAGR of 6.6% from 2018 to 2025. (medgadget.com)
  • as such, the molecular weight of slgA is 385,000D. One of these is the J chain (joining chain), which is a polypeptide of molecular mass 15kD, rich with cysteine and structurally completely different from other immunoglobulin chains. (wikipedia.org)
  • There is provided an isolated immunoglobulin comprising two heavy polypeptide chains sufficient for the formation of a complete antigen binding site or several antigen binding sites, wherein the immunoglobulin is further devoid of light polypeptide chains. (freepatentsonline.com)
  • The high prevalence of IgA in mucosal areas is a result of a cooperation between plasma cells that produce polymeric IgA (pIgA), and mucosal epithelial cells that express an immunoglobulin receptor called the polymeric Ig receptor (pIgR). (wikipedia.org)
  • It includes such functionally important members as the immunoglobulins themselves, major histocompatibility complex (MHC) class I and class II and T-cell receptor (TCR) molecules. (nih.gov)
  • 5. The composition of claim 1, wherein said immunoglobulins exhibit decreased binding affinity for an FcγRIIb receptor. (freepatentsonline.com)
  • 6. The composition of claim 1, wherein said immunoglobulins exhibit increased binding affinity for an FcγRIII receptor. (freepatentsonline.com)
  • again this FeRn receptor, is taking that immunoglobulin from the lumenside. (coursera.org)
  • After bone marrow transplant, it may be given to patients that have low levels of immunoglobulin. (oncolink.org)
  • For adults, elevated levels of immunoglobulin E or IgE are above 423 international units per milliliter of blood, according to WebMD. (reference.com)
  • The structure of immunoglobulin superfamily domains 1 and 2 of MAdCAM-1 reveals novel features important for integrin recognition. (ebi.ac.uk)
  • this (µL)2 structure is often referred to as the IgM "monomer", as it is analogous in some ways to the structure of immunoglobulin G (IgG). (wikipedia.org)
  • Overall, 2% of patients who had received IV immunoglobulin for various indications were affected, compared with 4.1% of controls who had not received the treatment ( P =0.002), Howard Fillit, MD, of Mount Sinai School of Medicine in New York, and colleagues reported in the July 21 issue of Neurology . (medpagetoday.com)
  • Loh RK, Vale S, Maclean-Tooke A. Quantitative serum immunoglobulin tests. (medlineplus.gov)
  • See the table of normal serum immunoglobulin ranges. (sigmaaldrich.com)
  • Serum immunoglobulin profiles of septicemic versus healthy neonates. (biomedsearch.com)
  • The Immunoglobulin E (IgE) ELISA Kit is for the quantitative determination of IgE in human serum. (mpbio.com)
  • Your search returned 4 immunoglobulin superfamily, member 10 Biomolecules across 2 suppliers. (biocompare.com)
  • We have designed a set of oligonucleotide primers to amplify the cDNA of mouse immunoglobulin heavy and light chain variable domains by the polymerase chain reaction. (pnas.org)
  • Normal immunoglobulin E, or IgE, levels in children are 10 international units per milliliter for 1-year-olds. (reference.com)
  • The V domains of normal immunoglobulin are highly heterogeneous, reflecting their role in protecting against the great variety of infectious microbes, and this heterogeneity impeded detailed structural analysis of IgM. (wikipedia.org)
  • [4] This represents up to 15% of total immunoglobulins produced throughout the body. (wikipedia.org)
  • To the extent that the experiments reflect the human condition, these studies offer insights into the pathogenesis of progressive kidney failure in the setting of lymphoproliferative disorders, such as multiple myeloma, that feature increased circulating levels of monoclonal immunoglobulin fragments that require metabolism by the kidney. (jci.org)
  • Dantal J. Intravenous immunoglobulins: in-depth review of excipients and acute kidney injury risk. (medscape.com)
  • High-dose intravenous immunoglobulins: an approach to treat severe immune-mediated and autoimmune diseases of the skin. (medscape.com)
  • Intravenous immunoglobulins improve survival in monoclonal gammopathy-associated systemic capillary-leak syndrome. (medscape.com)
  • The aim of this study is to study the efficacy of intravenous immunoglobulins for inducing remission in patients relapsing of systemic vasculitides. (clinicaltrials.gov)
  • Global Immunoglobulin Market Size 2017 Industry Trend and Forecast. (mynewsdesk.com)
  • The Global And China Immunoglobulin Industry 2017 Market Research Report is a professional and in-depth study on the current state of the Immunoglobulin industry. (mynewsdesk.com)
  • In the 1960s, methods were developed for inducing immunoglobulin-producing tumors (plasmacytomas) in mice, thus also providing a source of homogeneous immunoglobulins of various isotypes, including IgM (reviewed in). (wikipedia.org)
  • We found that a regulatory system in the prominent human commensal Bacteroides fragilis modulates its surface architecture to invite binding of immunoglobulin A (IgA) in mice. (sciencemag.org)
  • Represents 15-20% of the human serum immunoglobulins, mostly as the 4-chain polymer in humans or dimer in other mammals. (jove.com)
  • Your body makes different types of immunoglobulins to fight different types of these substances. (medlineplus.gov)
  • [2] A number of specific immunoglobulin formulations are also available including for hepatitis B , rabies , tetanus , varicella infection , and Rh positive blood exposure . (wikipedia.org)
  • In these situations, immunoglobulin infusions confer passive resistance to infection on their recipients by increasing the quantity/quality of IgG they possess. (wikipedia.org)
  • Immunoglobulin therapy is especially useful in some acute infection cases such as pediatric HIV infection and is also considered the standard of treatment for some autoimmune disorders such as Guillain-Barré syndrome . (wikipedia.org)
  • While researchers have known for years that immunoglobulin A (IgA) is important for gut health, it has remained unclear exactly what role it plays in preventing infection and disease. (news-medical.net)
  • If your immunoglobulin levels are too high, it may be a sign of an autoimmune disease, a chronic illness, an infection, or a type of cancer. (medlineplus.gov)
  • Accordingly, a novel approach in prevention and reduction of H. pylori infection has been reported based on production of urease-specific immunoglobulin that can suppress the bacterial colonization through urease-binding by anti- H. pylori urease IgY (IgY-urease). (scirp.org)
  • Human immunoglobulin therapy first occurred in the 1930s and a formulation for injection into a vein was approved for medical use in the United States in 1981. (wikipedia.org)
  • Immunoglobulin therapy is also used for a number of other conditions, including in many autoimmune disorders such as dermatomyositis in an attempt to decrease the severity of symptoms. (wikipedia.org)
  • Immunoglobulin therapy is also used in some treatment protocols for secondary immunodeficiencies such as human immunodeficiency virus (HIV), some autoimmune disorders (such as immune thrombocytopenia and Kawasaki disease ), some neurological diseases ( multifocal motor neuropathy , stiff person syndrome , multiple sclerosis and myasthenia gravis ) some acute infections and some complications of organ transplantation. (wikipedia.org)
  • Different national bodies and medical associations have established varying standards for the use of immunoglobulin therapy. (wikipedia.org)
  • The National Advisory Committee on Blood and Blood Products of Canada (NAC) and Canadian Blood Services have also developed their own separate set of guidelines for the appropriate use of immunoglobulin therapy, which strongly support the use of immunoglobulin therapy in primary immunodeficiencies and some complications of HIV, while remaining silent on the issues of sepsis, multiple sclerosis, and chronic fatigue syndrome. (wikipedia.org)
  • Replacement therapy is not practical for IgAD because of the short half-life of IgA and the relative paucity of IgA in commercial immunoglobulin preparations. (medscape.com)
  • In November 2011, the IDF Medical Advisory Committee wrote a resolution regarding formulary changes that limit a physician's ability to determine the most appropriate immunoglobulin replacement therapy. (primaryimmune.org)
  • Review of intravenous immunoglobulin replacement therapy trials for primary humoral immunodeficiency patients. (medscape.com)
  • It was initially expected that J chain would be important for forming the polymeric immunoglobulins, and indeed polymerization of IgA depends strongly (but not absolutely) on J chain. (wikipedia.org)
  • Genetic rearrangements occur during the maturation of B lymphocytes, eventually resulting in the surface expression of both immunoglobulin M (IgM) and IgD on mature B cells. (medscape.com)
  • The interspecific fusion of normal bovine lymphocytes with a nonsecreting mouse hybridoma produced stable cell lines secreting bovine immunoglobulins. (sciencemag.org)
  • Immunoglobulins (Igs) are glycoproteins. (chegg.com)
  • The Chinese company added that the bovine immunoglobulin G (IgG) kits helps to prevent and treat blue ear disease, respiratory pneumonia, pseudorabies, swine fever and foot and mouth disease, which are common diseases affecting pig in the farming industry. (thefreedictionary.com)
  • IV immunoglobulin has been used safely for more than 20 years to treat other diseases but is thought to have an indirect effect on Alzheimer's disease by targeting beta-amyloid," Dr. Fillit said. (medpagetoday.com)
  • And if I remember correctly these diseases occur with low immunoglobulin counts so the immunoglobulin being administered via IV may be to increase the levels as opposed to replenish the levels. (wisegeek.com)
  • Intramuscular immunoglobulin for recalcitrant suppurative diseases of the skin: a retrospective review of 63 cases. (medscape.com)
  • And even though immunoglobulins are obtained from blood, they are purified so that they can't pass on diseases to the person who receives them. (wellspan.org)
  • You may be given an immunoglobulin if you are exposed to certain infectious diseases, such as hepatitis A , rubella , or measles. (wellspan.org)
  • As the number of patients suffering from pathological conditions and autoimmune diseases has been escalating by the day, the global demand for intravenous immunoglobulin is expected to multiply. (sbwire.com)
  • Barnett C, Wilson G, Barth D, Katzberg HD, Bril V. Changes in quality of life scores with intravenous immunoglobulin or plasmapheresis in patients with myasthenia gravis. (medscape.com)
  • Sorgun MH, Sener HO, Yucesan C, Yucemen N. Intravenous immunoglobulin for prophylaxis of acute exacerbation in Myasthenia Gravis. (medscape.com)
  • [1] Human immunoglobulin is made from human blood plasma . (wikipedia.org)
  • Immunoglobulin G (IgG) holds the highest share (44%) in the global blood plasma market, with a revenue of $9.24 billion. (frost.com)
  • Immunoglobulin can be collected from the plasma of donated blood. (oncolink.org)
  • The main immunoglobulin of blood, lymph, and tissue fluid is immunoglobulin G ( IgG ). (encyclopedia.com)
  • Immunoglobulin E ( IgE ) also normally has very low concentrations in blood and connective tissues, but it plays a crucial role in allergic reactions. (encyclopedia.com)
  • Precautions must be used in the administration of IV immunoglobulin and other blood products in patients with IgAD because IV immunoglobulin preparations and other blood products contain at least small amounts of IgA. (medscape.com)
  • What is an immunoglobulins blood test? (medlineplus.gov)
  • Why do I need an immunoglobulins blood test? (medlineplus.gov)
  • You don't need any special preparations for an immunoglobulins blood test. (medlineplus.gov)
  • Tenders are invited for reagents for the determination of TORCH infections, hepatitis, parasites ELISA: A set of reagents for the detection of immunoglobulin G antigens opistorhysiv, Trichinella, Echinococcus and toxocara serum (plasma) of human blood by ELISA. (thefreedictionary.com)
  • Immunoglobulin is sometimes used to treat immune thrombocytopenic purpura (ITP), an immune disorder in which the body attacks the cells responsible for blood clotting (platelets), resulting in bleeding. (wellspan.org)
  • An intravenous (IV) infusion of a substance made from human blood plasma (immunoglobulin) may be given. (wellspan.org)
  • As one of the 5 immunoglobulins found in the blood, it is a long-lasting defense against most antigens. (healthtestingcenters.com)
  • As one of the 5 immunoglobulins found in the blood ,it is the first or primary immunoglobulin produced following exposure to an antigen. (healthtestingcenters.com)
  • Egg yolk immunoglobulin (IgY) can successfully compete with immunoglobulin (IgG) produced in the blood of mammals. (scirp.org)
  • Cultures of blood were done and serum immunoglobulins (IgG, IgA) were estimated in all the subjects. (biomedsearch.com)
  • Zoster Immunoglobulin-VF is prepared from blood obtained from voluntary donors. (nps.org.au)
  • The present study demonstrated that during the process of metabolism of immunoglobulin FLCs, ROS activated the STAT1 pathway in proximal tubule epithelium. (jci.org)
  • Antithymocyte Globulin (ATG) is a concentrated anti-human T-lymphocyte immunoglobulin preparation derived from rabbits after immunization with a T-lympoblast cell line. (drugbank.ca)
  • however, other immunoglobulins are distributed into human milk. (drugbank.ca)
  • A wide range of human and animal immunoglobulins (Igs) for use in immunological and biochemical applications have been isolated from normal or myeloma sources. (sigmaaldrich.com)
  • Explain to interested patients that this study identified an association between previous IV immunoglobulin use and a lower risk of Alzheimer's disease, but as a retrospective study subject to residual confounding, it could not prove causality. (medpagetoday.com)
  • Point out that a clinical trial is underway to evaluate the use of IV immunoglobulin in patients with Alzheimer's disease. (medpagetoday.com)
  • Small, preliminary studies of IV immunoglobulin treatment for patients with Alzheimer's disease have yielded positive results. (medpagetoday.com)
  • These patients were matched by age, gender, and risk factors for Alzheimer's disease and related disorders with 84,700 controls who had not received IV immunoglobulin. (medpagetoday.com)
  • Overall, through about four years of follow-up, 2% of patients treated with IV immunoglobulin developed Alzheimer's disease or a similar disorder, compared with 4.1% of the controls. (medpagetoday.com)
  • Restricting access of subscribers to only one or two product/formulations of replacement immunoglobulin regardless of the particular product the patient may currently be receiving poses an unjustified safety risk for patients. (primaryimmune.org)
  • Doctors should cease using Octagam intravenous immunoglobulin solutions immediately, and switch their patients to the most appropriate alternative treatment. (tga.gov.au)
  • Patients and health care providers should report any adverse events that have occurred following administration of Octagam intravenous immunoglobulin solution to the TGA via the Adverse Medicine Events Line (1300 134 237), online via ' Report a problem with a medicine ', or using the 'Blue Card' Prepaid Reporting Form . (tga.gov.au)
  • Patients with immunoglobulin G4-related disease (IgG4-related disease) can present to any clinical specialty. (cmaj.ca)
  • Large patient population, lack of effective substitute treatment, and early adoption of immunoglobulin for the treatment of hypogammaglobulinemia are expected to boost the growth of this segment. (medgadget.com)
  • North America, with the U.S. at the fore, is expected to witness greatest demand for intravenous immunoglobulin over the next few years, emerging as the leading segment of the market. (sbwire.com)
  • This gene encodes a member of the immunoglobulin-like domain-containing superfamily. (nih.gov)
  • [1] [2] These conditions include primary immunodeficiency , immune thrombocytopenic purpura , chronic inflammatory demyelinating polyneuropathy , Kawasaki disease , certain cases of HIV/AIDS and measles , Guillain-Barré syndrome , and certain other infections when a more specific immunoglobulin is not available. (wikipedia.org)
  • What is immunoglobulin A (IgA) nephropathy? (medscape.com)
  • Immunoglobulin A (IgA) nephropathy is characterized by predominant IgA deposition in the glomerular mesangium. (medscape.com)
  • Light microscopy of a glomerulus from a patient with immunoglobulin A nephropathy showing increased mesangial matrix and cellularity. (medscape.com)
  • Immunofluorescence microscopy demonstrating large mesangial immunoglobulin A (IgA) deposits diagnostic of IgA nephropathy. (medscape.com)
  • Immunoglobulin A nephropathy: a pathophysiology view. (medscape.com)
  • Immunoglobulin A ( IgA ) is found in saliva, tears, breast milk, and mucous secretions, where its role is to neutralize viruses and bacteria as they enter the body. (encyclopedia.com)
  • Immunoglobulin (Ig) therapies are among the oldest therapeutic moieties employed in a broad range of pathological conditions. (frost.com)
  • Is dosing of therapeutic immunoglobulins optimal? (medscape.com)
  • The Therapeutic Goods Administration (TGA) advises that Octapharma Australia Pty Ltd has agreed to a precautionary voluntary recall of all batches of Octagam intravenous immunoglobulin solutions from the Australian market, due to safety concerns regarding an increased incidence of thromboembolic complications associated with the use of this product in Europe and the USA. (tga.gov.au)
  • LITTLE FALLS, N.J., July 20 -- Intravenous immunoglobulin treatment was associated with a 42% reduced risk of developing Alzheimer's disease and similar disorders, a case-control study showed. (medpagetoday.com)
  • He cautioned, however, that "these findings do not constitute an endorsement of IV immunoglobulin treatment for Alzheimer's disease. (medpagetoday.com)
  • The aim of this study will assess the effects of intravenous immunoglobulin in ANCA+ vasculitides (Microscopic Polyangiitis, Wegener's granulomatosis and Churg-Strauss syndrome) who relapse under corticosteroid and immunosuppressant therapies or after one year post treatment. (clinicaltrials.gov)
  • Based on application, the global intravenous immunoglobulin market has been segmented into disease treatment, disease prevention, and disease research. (sbwire.com)
  • Some placental trophoblasts also bind to immunoglobulins, in order for them to be carried across to the fetus for providing immunity for the growing child. (chegg.com)
  • Although lymphocyte-like cells secreting somatically-recombining receptors have been identified in the jawless fishes (hagfish and lamprey), the cartilaginous fishes (sharks, skates, rays and chimaera) are the most phylogenetically distant group relative to mammals in which bona fide immunoglobulins (Igs) have been found. (mdpi.com)
  • If you are suffering from cirrhosis of the liver or rheumatoid arthritis and therefore you have high levels of IgA, will you ever need to replace or get any more immunoglobulin via intravenously (more often said as receiving immunoglobulin via iv) or maybe have an immunoglobulin infusion? (wisegeek.com)