Immunoglobulin e. Medical search

An immunoglobulin associated with MAST CELLS. Overexpression has been associated with allergic hypersensitivity (HYPERSENSITIVITY, IMMEDIATE).

The major immunoglobulin isotype class in normal human serum. There are several isotype subclasses of IgG, for example, IgG1, IgG2A, and IgG2B.

Multi-subunit proteins which function in IMMUNITY. They are produced by B LYMPHOCYTES from the IMMUNOGLOBULIN GENES. They are comprised of two heavy (IMMUNOGLOBULIN HEAVY CHAINS) and two light chains (IMMUNOGLOBULIN LIGHT CHAINS) with additional ancillary polypeptide chains depending on their isoforms. The variety of isoforms include monomeric or polymeric forms, and transmembrane forms (B-CELL ANTIGEN RECEPTORS) or secreted forms (ANTIBODIES). They are divided by the amino acid sequence of their heavy chains into five classes (IMMUNOGLOBULIN A; IMMUNOGLOBULIN D; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M) and various subclasses.

A class of immunoglobulin bearing mu chains (IMMUNOGLOBULIN MU-CHAINS). IgM can fix COMPLEMENT. The name comes from its high molecular weight and originally being called a macroglobulin.

Represents 15-20% of the human serum immunoglobulins, mostly as the 4-chain polymer in humans or dimer in other mammals. Secretory IgA (IMMUNOGLOBULIN A, SECRETORY) is the main immunoglobulin in secretions.

Specific molecular sites on the surface of B- and T-lymphocytes which combine with IgEs. Two subclasses exist: low affinity receptors (Fc epsilon RII) and high affinity receptors (Fc epsilon RI).

The largest of polypeptide chains comprising immunoglobulins. They contain 450 to 600 amino acid residues per chain, and have molecular weights of 51-72 kDa.

Antigen-type substances that produce immediate hypersensitivity (HYPERSENSITIVITY, IMMEDIATE).

Immunoglobulin preparations used in intravenous infusion, containing primarily IMMUNOGLOBULIN G. They are used to treat a variety of diseases associated with decreased or abnormal immunoglobulin levels including pediatric AIDS; primary HYPERGAMMAGLOBULINEMIA; SCID; CYTOMEGALOVIRUS infections in transplant recipients, LYMPHOCYTIC LEUKEMIA, CHRONIC; Kawasaki syndrome, infection in neonates, and IDIOPATHIC THROMBOCYTOPENIC PURPURA.

Genes encoding the different subunits of the IMMUNOGLOBULINS, for example the IMMUNOGLOBULIN LIGHT CHAIN GENES and the IMMUNOGLOBULIN HEAVY CHAIN GENES. The heavy and light immunoglobulin genes are present as gene segments in the germline cells. The completed genes are created when the segments are shuffled and assembled (B-LYMPHOCYTE GENE REARRANGEMENT) during B-LYMPHOCYTE maturation. The gene segments of the human light and heavy chain germline genes are symbolized V (variable), J (joining) and C (constant). The heavy chain germline genes have an additional segment D (diversity).

Altered reactivity to an antigen, which can result in pathologic reactions upon subsequent exposure to that particular antigen.

Polypeptide chains, consisting of 211 to 217 amino acid residues and having a molecular weight of approximately 22 kDa. There are two major types of light chains, kappa and lambda. Two Ig light chains and two Ig heavy chains (IMMUNOGLOBULIN HEAVY CHAINS) make one immunoglobulin molecule.

Hypersensitivity reactions which occur within minutes of exposure to challenging antigen due to the release of histamine which follows the antigen-antibody reaction and causes smooth muscle contraction and increased vascular permeability.

Granular leukocytes characterized by a relatively pale-staining, lobate nucleus and cytoplasm containing coarse dark-staining granules of variable size and stainable by basic dyes.

Epicutaneous or intradermal application of a sensitizer for demonstration of either delayed or immediate hypersensitivity. Used in diagnosis of hypersensitivity or as a test for cellular immunity.

One of the types of light chains of the immunoglobulins with a molecular weight of approximately 22 kDa.

Gastrointestinal disturbances, skin eruptions, or shock due to allergic reactions to allergens in food.

The classes of immunoglobulins found in any species of animal. In man there are nine classes that migrate in five different groups in electrophoresis; they each consist of two light and two heavy protein chains, and each group has distinguishing structural and functional properties.

Granulated cells that are found in almost all tissues, most abundantly in the skin and the gastrointestinal tract. Like the BASOPHILS, mast cells contain large amounts of HISTAMINE and HEPARIN. Unlike basophils, mast cells normally remain in the tissues and do not circulate in the blood. Mast cells, derived from the bone marrow stem cells, are regulated by the STEM CELL FACTOR.

The principle immunoglobulin in exocrine secretions such as milk, respiratory and intestinal mucin, saliva and tears. The complete molecule (around 400 kD) is composed of two four-chain units of IMMUNOGLOBULIN A, one SECRETORY COMPONENT and one J chain (IMMUNOGLOBULIN J-CHAINS).

That region of the immunoglobulin molecule that varies in its amino acid sequence and composition, and comprises the binding site for a specific antigen. It is located at the N-terminus of the Fab fragment of the immunoglobulin. It includes hypervariable regions (COMPLEMENTARITY DETERMINING REGIONS) and framework regions.

Lymphoid cells concerned with humoral immunity. They are short-lived cells resembling bursa-derived lymphocytes of birds in their production of immunoglobulin upon appropriate stimulation.

Crystallizable fragments composed of the carboxy-terminal halves of both IMMUNOGLOBULIN HEAVY CHAINS linked to each other by disulfide bonds. Fc fragments contain the carboxy-terminal parts of the heavy chain constant regions that are responsible for the effector functions of an immunoglobulin (COMPLEMENT fixation, binding to the cell membrane via FC RECEPTORS, and placental transport). This fragment can be obtained by digestion of immunoglobulins with the proteolytic enzyme PAPAIN.

The class of heavy chains found in IMMUNOGLOBULIN M. They have a molecular weight of approximately 72 kDa and they contain about 57 amino acid residues arranged in five domains and have more oligosaccharide branches and a higher carbohydrate content than the heavy chains of IMMUNOGLOBULIN G.

An in vitro allergen radioimmunoassay in which allergens are coupled to an immunosorbent. The coupled allergens bind the IgE in the sera of patients which in turn binds radioisotope-labeled anti-IMMUNOGLOBULIN E antibodies.

Gene rearrangement of the B-lymphocyte which results in a substitution in the type of heavy-chain constant region that is expressed. This allows the effector response to change while the antigen binding specificity (variable region) remains the same. The majority of class switching occurs by a DNA recombination event but it also can take place at the level of RNA processing.

One of the types of light chain subunits of the immunoglobulins with a molecular weight of approximately 22 kDa.

A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).

Antibodies which react with the individual structural determinants (idiotopes) on the variable region of other antibodies.

An immunoglobulin which accounts for less than 1% of plasma immunoglobulin. It is found on the membrane of many circulating B LYMPHOCYTES.

The secretion of histamine from mast cell and basophil granules by exocytosis. This can be initiated by a number of factors, all of which involve binding of IgE, cross-linked by antigen, to the mast cell or basophil's Fc receptors. Once released, histamine binds to a number of different target cell receptors and exerts a wide variety of effects.

A soluble factor produced by activated T-LYMPHOCYTES that induces the expression of MHC CLASS II GENES and FC RECEPTORS on B-LYMPHOCYTES and causes their proliferation and differentiation. It also acts on T-lymphocytes, MAST CELLS, and several other hematopoietic lineage cells.

The domains of the immunoglobulin molecules that are invariable in their amino acid sequence within any class or subclass of immunoglobulin. They confer biological as well as structural functions to immunoglobulins. One each on both the light chains and the heavy chains comprises the C-terminus half of the IMMUNOGLOBULIN FAB FRAGMENT and two or three of them make up the rest of the heavy chains (all of the IMMUNOGLOBULIN FC FRAGMENT)

The class of heavy chains found in IMMUNOGLOBULIN E. They have a molecular weight of approximately 72 kDa and they contain about 550 amino acid residues arranged in five domains and about three times more carbohydrate than the heavy chains of IMMUNOGLOBULIN A; IMMUNOGLOBULIN D; and IMMUNOGLOBULIN G.

A chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. It is manifested by lichenification, excoriation, and crusting, mainly on the flexural surfaces of the elbow and knee. In infants it is known as infantile eczema.

An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.

Molecules found on the surface of some, but not all, B-lymphocytes, T-lymphocytes, and macrophages, which recognize and combine with the Fc (crystallizable) portion of immunoglobulin molecules.

Substances found in PLANTS that have antigenic activity.

An acute hypersensitivity reaction due to exposure to a previously encountered ANTIGEN. The reaction may include rapidly progressing URTICARIA, respiratory distress, vascular collapse, systemic SHOCK, and death.

Allergic reaction to products containing processed natural rubber latex such as rubber gloves, condoms, catheters, dental dams, balloons, and sporting equipment. Both T-cell mediated (HYPERSENSITIVITY, DELAYED) and IgE antibody-mediated (HYPERSENSITIVITY, IMMEDIATE) allergic responses are possible. Delayed hypersensitivity results from exposure to antioxidants present in the rubber; immediate hypersensitivity results from exposure to a latex protein.

The property of antibodies which enables them to react with some ANTIGENIC DETERMINANTS and not with others. Specificity is dependent on chemical composition, physical forces, and molecular structure at the binding site.

Heavy chains of IMMUNOGLOBULIN G having a molecular weight of approximately 51 kDa. They contain about 450 amino acid residues arranged in four domains and an oligosaccharide component covalently bound to the Fc fragment constant region. The gamma heavy chain subclasses (for example, gamma 1, gamma 2a, and gamma 2b) of the IMMUNOGLOBULIN G isotype subclasses (IgG1, IgG2A, and IgG2B) resemble each other more closely than the heavy chains of the other IMMUNOGLOBULIN ISOTYPES.

A rare acute myeloid leukemia in which the primary differentiation is to BASOPHILS. It is characterized by an extreme increase of immature basophilic granulated cells in the bone marrow and blood. Mature basophils are usually sparse.

Univalent antigen-binding fragments composed of one entire IMMUNOGLOBULIN LIGHT CHAIN and the amino terminal end of one of the IMMUNOGLOBULIN HEAVY CHAINS from the hinge region, linked to each other by disulfide bonds. Fab contains the IMMUNOGLOBULIN VARIABLE REGIONS, which are part of the antigen-binding site, and the first IMMUNOGLOBULIN CONSTANT REGIONS. This fragment can be obtained by digestion of immunoglobulins with the proteolytic enzyme PAPAIN.

Family of MITES, in the superfamily Acaroidea, order Astigmata. They are frequently found in cereal-based foodstuffs including GRAIN and FLOUR.

Inflammation of the mucous membrane of the nose similar to that found in hay fever except that symptoms persist throughout the year. The causes are usually air-borne allergens, particularly dusts, feathers, molds, animal fur, etc.

A 15 kD "joining" peptide that forms one of the linkages between monomers of IMMUNOGLOBULIN A or IMMUNOGLOBULIN M in the formation of polymeric immunoglobulins. There is one J chain per one IgA dimer or one IgM pentamer. It is also involved in binding the polymeric immunoglobulins to POLYMERIC IMMUNOGLOBULIN RECEPTOR which is necessary for their transcytosis to the lumen. It is distinguished from the IMMUNOGLOBULIN JOINING REGION which is part of the IMMUNOGLOBULIN VARIABLE REGION of the immunoglobulin light and heavy chains.

Partial immunoglobulin molecules resulting from selective cleavage by proteolytic enzymes or generated through PROTEIN ENGINEERING techniques.

Allergic rhinitis that occurs at the same time every year. It is characterized by acute CONJUNCTIVITIS with lacrimation and ITCHING, and regarded as an allergic condition triggered by specific ALLERGENS.

Allelic variants of the immunoglobulin light chains (IMMUNOGLOBULIN LIGHT CHAINS) or heavy chains (IMMUNOGLOBULIN HEAVY CHAINS) encoded by ALLELES of IMMUNOGLOBULIN GENES.

An evanescent cutaneous reaction occurring when antibody is injected into a local area on the skin and antigen is subsequently injected intravenously along with a dye. The dye makes the rapidly occurring capillary dilatation and increased vascular permeability readily visible by leakage into the reaction site. PCA is a sensitive reaction for detecting very small quantities of antibodies and is also a method for studying the mechanisms of immediate hypersensitivity.

Specialized Fc receptors (RECEPTORS, FC) for polymeric immunoglobulins, which mediate transcytosis of polymeric IMMUNOGLOBULIN A and IMMUNOGLOBULIN M into external secretions. They are found on the surfaces of epithelial cells and hepatocytes. After binding to IMMUNOGLOBULIN A, the receptor-ligand complex undergoes endocytosis, transport by vesicle, and secretion into the lumen by exocytosis. Before release, the part of the receptor (SECRETORY COMPONENT) that is bound to IMMUNOGLOBULIN A is proteolytically cleaved from its transmembrane tail. (From Rosen et al., The Dictionary of Immunology, 1989)

An albumin obtained from the white of eggs. It is a member of the serpin superfamily.

Allergic reaction to milk (usually cow's milk) or milk products. MILK HYPERSENSITIVITY should be differentiated from LACTOSE INTOLERANCE, an intolerance to milk as a result of congenital deficiency of lactase.

Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.

A segment of the immunoglobulin heavy chains, encoded by the IMMUNOGLOBULIN HEAVY CHAIN GENES in the J segment where, during the maturation of B-LYMPHOCYTES; the gene segment for the variable region upstream is joined to a constant region gene segment downstream. The exact position of joining of the two gene segments is variable and contributes to ANTIBODY DIVERSITY. It is distinguished from the IMMUNOGLOBULIN J CHAINS; a separate polypeptide that serves as a linkage piece in polymeric IGA or IGM.

Immunoglobulins produced in a response to BACTERIAL ANTIGENS.

Membrane antigens associated with maturation stages of B-lymphocytes, often expressed in tumors of B-cell origin.

Tendency of the smooth muscle of the tracheobronchial tree to contract more intensely in response to a given stimulus than it does in the response seen in normal individuals. This condition is present in virtually all symptomatic patients with asthma. The most prominent manifestation of this smooth muscle contraction is a decrease in airway caliber that can be readily measured in the pulmonary function laboratory.

A form of hypersensitivity affecting the respiratory tract. It includes ASTHMA and RHINITIS, ALLERGIC, SEASONAL.

An excess of GAMMA-GLOBULINS in the serum due to chronic infections or PARAPROTEINEMIAS.

The production of ANTIBODIES by proliferating and differentiated B-LYMPHOCYTES under stimulation by ANTIGENS.

Subset of helper-inducer T-lymphocytes which synthesize and secrete the interleukins IL-4, IL-5, IL-6, and IL-10. These cytokines influence B-cell development and antibody production as well as augmenting humoral responses.

Any arthropod of the subclass ACARI except the TICKS. They are minute animals related to the spiders, usually having transparent or semitransparent bodies. They may be parasitic on humans and domestic animals, producing various irritations of the skin (MITE INFESTATIONS). Many mite species are important to human and veterinary medicine as both parasite and vector. Mites also infest plants.

Immunoglobulins produced in a response to HELMINTH ANTIGENS.

Antigens from the house dust mites (DERMATOPHAGOIDES), mainly D. farinae and D. pteronyssinus. They are proteins, found in mite feces or mite extracts, that can cause ASTHMA and other allergic diseases such as perennial rhinitis (RHINITIS, ALLERGIC, PERENNIAL) and atopic dermatitis (DERMATITIS, ATOPIC). More than 11 groups of Dermatophagoides ALLERGENS have been defined. Group I allergens, such as Der f I and Der p I from the above two species, are among the strongest mite immunogens in humans.

Allergic reaction to eggs that is triggered by the immune system.

Antibodies produced by a single clone of cells.

Allergic reaction to peanuts that is triggered by the immune system.

The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.

The process of losing secretory granules (SECRETORY VESICLES). This occurs, for example, in mast cells, basophils, neutrophils, eosinophils, and platelets when secretory products are released from the granules by EXOCYTOSIS.

The fertilizing element of plants that contains the male GAMETOPHYTES.

Agents that are used to treat allergic reactions. Most of these drugs act by preventing the release of inflammatory mediators or inhibiting the actions of released mediators on their target cells. (From AMA Drug Evaluations Annual, 1994, p475)

Skin tests in which the sensitizer is injected.

The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.

IMMUNOGLOBULINS on the surface of B-LYMPHOCYTES. Their MESSENGER RNA contains an EXON with a membrane spanning sequence, producing immunoglobulins in the form of type I transmembrane proteins as opposed to secreted immunoglobulins (ANTIBODIES) which do not contain the membrane spanning segment.

Serological reactions in which an antiserum against one antigen reacts with a non-identical but closely related antigen.

Immunoglobulins produced in a response to FUNGAL ANTIGENS.

Abnormal immunoglobulins characteristic of MULTIPLE MYELOMA.

An encapsulated lymphatic organ through which venous blood filters.

Deliberate stimulation of the host's immune response. ACTIVE IMMUNIZATION involves administration of ANTIGENS or IMMUNOLOGIC ADJUVANTS. PASSIVE IMMUNIZATION involves administration of IMMUNE SERA or LYMPHOCYTES or their extracts (e.g., transfer factor, immune RNA) or transplantation of immunocompetent cell producing tissue (thymus or bone marrow).

Substances that are recognized by the immune system and induce an immune reaction.

Genes and gene segments encoding the IMMUNOGLOBULIN HEAVY CHAINS. Gene segments of the heavy chain genes are symbolized V (variable), D (diversity), J (joining), and C (constant).

A programmed mutation process whereby changes are introduced to the nucleotide sequence of immunoglobulin gene DNA during development.

Any discrete, presumably solitary, mass of neoplastic PLASMA CELLS either in BONE MARROW or various extramedullary sites.

Any part or derivative of a helminth that elicits an immune reaction. The most commonly seen helminth antigens are those of the schistosomes.

A cytokine that promotes differentiation and activation of EOSINOPHILS. It also triggers activated B-LYMPHOCYTES to differentiate into IMMUNOGLOBULIN-secreting cells.

The class of heavy chains found in IMMUNOGLOBULIN D. They have a molecular weight of approximately 64 kDa and they contain about 500 amino acid residues arranged in four domains and an oligosaccharide component covalently bound to the Fc fragment constant region.

A family of CRUSTACEA, order DECAPODA, comprising the pandalid shrimp. They are protandric hermaphrodites and can breed in both male and female stages. Many species are commercially harvested in the Pacific Northwest.

A site located in the INTRONS at the 5' end of each constant region segment of a immunoglobulin heavy-chain gene where recombination (or rearrangement) occur during IMMUNOGLOBULIN CLASS SWITCHING. Ig switch regions are found on genes encoding all five classes (IMMUNOGLOBULIN ISOTYPES) of IMMUNOGLOBULIN HEAVY CHAINS.

Immunosuppression by the administration of increasing doses of antigen. Though the exact mechanism is not clear, the therapy results in an increase in serum levels of allergen-specific IMMUNOGLOBULIN G, suppression of specific IgE, and an increase in suppressor T-cell activity.

Primary immunodeficiency syndrome characterized by recurrent infections and hyperimmunoglobulinemia E. Most cases are sporadic. Of the rare familial forms, the dominantly inherited subtype has additional connective tissue, dental and skeletal involvement that the recessive type does not share.

Immunologically mediated adverse reactions to medicinal substances used legally or illegally.

The class of heavy chains found in IMMUNOGLOBULIN A. They have a molecular weight of approximately 58 kDa and contain about 470 amino acid residues arranged in four domains and an oligosaccharide component bound covalently to their Fc fragment constant region.

Hypersensitivity reaction (ALLERGIC REACTION) to fungus ASPERGILLUS in an individual with long-standing BRONCHIAL ASTHMA. It is characterized by pulmonary infiltrates, EOSINOPHILIA, elevated serum IMMUNOGLOBULIN E, and skin reactivity to Aspergillus antigen.

Unique genetically-controlled determinants present on ANTIBODIES whose specificity is limited to a single group of proteins (e.g., another antibody molecule or an individual myeloma protein). The idiotype appears to represent the antigenicity of the antigen-binding site of the antibody and to be genetically codetermined with it. The idiotypic determinants have been precisely located to the IMMUNOGLOBULIN VARIABLE REGION of both immunoglobin polypeptide chains.

Sites on an antigen that interact with specific antibodies.

Established cell cultures that have the potential to propagate indefinitely.

Family of house dust mites, in the superfamily Analgoidea, order Astigmata. They include the genera Dermatophagoides and Euroglyphus.

A specific immune response elicited by a specific dose of an immunologically active substance or cell in an organism, tissue, or cell.

Radioimmunoassay of proteins using antibody coupled to an immunosorbent.

A plant genus of the family FABACEAE that is a source of prosopis gum.

Serum globulins that migrate to the gamma region (most positively charged) upon ELECTROPHORESIS. At one time, gamma-globulins came to be used as a synonym for immunoglobulins since most immunoglobulins are gamma globulins and conversely most gamma globulins are immunoglobulins. But since some immunoglobulins exhibit an alpha or beta electrophoretic mobility, that usage is in decline.

Immunoglobulins produced in response to VIRAL ANTIGENS.

Granular leukocytes with a nucleus that usually has two lobes connected by a slender thread of chromatin, and cytoplasm containing coarse, round granules that are uniform in size and stainable by eosin.

Phthalic acid anhydrides. Can be substituted on any carbon atom. Used extensively in industry and as a reagent in the acylation of amino- and hydroxyl groups.

Immunoglobulins produced in a response to PROTOZOAN ANTIGENS.

Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.

Abnormal increase of EOSINOPHILS in the blood, tissues or organs.

Leukemia induced experimentally in animals by exposure to leukemogenic agents, such as VIRUSES; RADIATION; or by TRANSPLANTATION of leukemic tissues.

The extracellular moiety of the POLYMERIC IMMUNOGLOBULIN RECEPTOR found alone or complexed with IGA or IGM, in a variety of external secretions (tears, bile, colostrum.) Secretory component is derived by proteolytic cleavage of the receptor during transcytosis. When immunoglobulins IgA and IgM are bound to the receptor, during their transcytosis secretory component becomes covalently attached to them generating SECRETORY IMMUNOGLOBULIN A or secretory IMMUNOGLOBULIN M.

A cytokine synthesized by T-LYMPHOCYTES that produces proliferation, immunoglobulin isotype switching, and immunoglobulin production by immature B-LYMPHOCYTES. It appears to play a role in regulating inflammatory and immune responses.

A pruritic papulovesicular dermatitis occurring as a reaction to many endogenous and exogenous agents (Dorland, 27th ed).

Immunoglobulin molecules having a specific amino acid sequence by virtue of which they interact only with the ANTIGEN (or a very similar shape) that induced their synthesis in cells of the lymphoid series (especially PLASMA CELLS).

White blood cells formed in the body's lymphoid tissue. The nucleus is round or ovoid with coarse, irregularly clumped chromatin while the cytoplasm is typically pale blue with azurophilic (if any) granules. Most lymphocytes can be classified as either T or B (with subpopulations of each), or NATURAL KILLER CELLS.

An immunologic deficiency state characterized by an extremely low level of generally all classes of gamma-globulin in the blood.

Lymphocytes responsible for cell-mediated immunity. Two types have been identified - cytotoxic (T-LYMPHOCYTES, CYTOTOXIC) and helper T-lymphocytes (T-LYMPHOCYTES, HELPER-INDUCER). They are formed when lymphocytes circulate through the THYMUS GLAND and differentiate to thymocytes. When exposed to an antigen, they divide rapidly and produce large numbers of new T cells sensitized to that antigen.

Infection with roundworms of the genus ANISAKIS. Human infection results from the consumption of fish harboring roundworm larvae. The worms may cause acute NAUSEA; VOMITING; or penetrate into the wall of the DIGESTIVE TRACT where they give rise to EOSINOPHILIC GRANULOMA in the STOMACH; INTESTINES; or the OMENTUM.

A plant genus of the family RHAMNACEAE. Members contain nummularogenin (a spirostane) and is the source of an edible fruit.

Non-antibody proteins secreted by inflammatory leukocytes and some non-leukocytic cells, that act as intercellular mediators. They differ from classical hormones in that they are produced by a number of tissue or cell types rather than by specialized glands. They generally act locally in a paracrine or autocrine rather than endocrine manner.

Chemically stimulated aggregation of cell surface receptors, which potentiates the action of the effector cell.

An in vitro test used in the diagnosis of allergies including drug hypersensitivity. The allergen is added to the patient's white blood cells and the subsequent histamine release is measured.

Allelic variants of the gamma-immunoglobulin heavy chain (IMMUNOGLOBULIN GAMMA-CHAINS) encoded by ALLELES of IMMUNOGLOBULIN HEAVY CHAIN GENES.

Proteins synthesized by organisms belonging to the phylum ARTHROPODA. Included in this heading are proteins from the subdivisions ARACHNIDA; CRUSTACEA; and HORSESHOE CRABS. Note that a separate heading for INSECT PROTEINS is listed under this heading.

A milky, product excreted from the latex canals of a variety of plant species that contain cauotchouc. Latex is composed of 25-35% caoutchouc, 60-75% water, 2% protein, 2% resin, 1.5% sugar & 1% ash. RUBBER is made by the removal of water from latex.(From Concise Encyclopedia Biochemistry and Molecular Biology, 3rd ed). Hevein proteins are responsible for LATEX HYPERSENSITIVITY. Latexes are used as inert vehicles to carry antibodies or antigens in LATEX FIXATION TESTS.

Inflammation of the NASAL MUCOSA, the mucous membrane lining the NASAL CAVITIES.

The thin, yellow, serous fluid secreted by the mammary glands during pregnancy and immediately postpartum before lactation begins. It consists of immunologically active substances, white blood cells, water, protein, fat, and carbohydrates.

Tests involving inhalation of allergens (nebulized or in dust form), nebulized pharmacologically active solutions (e.g., histamine, methacholine), or control solutions, followed by assessment of respiratory function. These tests are used in the diagnosis of asthma.

Morphologic alteration of small B LYMPHOCYTES or T LYMPHOCYTES in culture into large blast-like cells able to synthesize DNA and RNA and to divide mitotically. It is induced by INTERLEUKINS; MITOGENS such as PHYTOHEMAGGLUTININS, and by specific ANTIGENS. It may also occur in vivo as in GRAFT REJECTION.

Transfer of immunity from immunized to non-immune host by administration of serum antibodies, or transplantation of lymphocytes (ADOPTIVE TRANSFER).

Cell surface molecules on cells of the immune system that specifically bind surface molecules or messenger molecules and trigger changes in the behavior of cells. Although these receptors were first identified in the immune system, many have important functions elsewhere.

A family of neutral serine proteases with CHYMOTRYPSIN-like activity. Chymases are primarily found in the SECRETORY GRANULES of MAST CELLS and are released during mast cell degranulation.

Local surface sites on antibodies which react with antigen determinant sites on antigens (EPITOPES.) They are formed from parts of the variable regions of FAB FRAGMENTS.

The complex formed by the binding of antigen and antibody molecules. The deposition of large antigen-antibody complexes leading to tissue damage causes IMMUNE COMPLEX DISEASES.

Small antigenic determinants capable of eliciting an immune response only when coupled to a carrier. Haptens bind to antibodies but by themselves cannot elicit an antibody response.

A technique that combines protein electrophoresis and double immunodiffusion. In this procedure proteins are first separated by gel electrophoresis (usually agarose), then made visible by immunodiffusion of specific antibodies. A distinct elliptical precipitin arc results for each protein detectable by the antisera.

A genus of nematodes of the superfamily ASCARIDOIDEA. Its organisms are found in the stomachs of marine animals and birds. Human infection occurs by ingestion of raw fish that contain larvae.

Species of European house dust mite, in the family PYROGLYPHIDAE. It is the most commonly found house dust mite.

Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood.

Ordered rearrangement of B-lymphocyte variable gene regions of the IMMUNOGLOBULIN HEAVY CHAINS, thereby contributing to antibody diversity. It occurs during the first stage of differentiation of the IMMATURE B-LYMPHOCYTES.

A species of parasitic nematode causing Malayan filariasis and having a distribution centering roughly on the Malay peninsula. The life cycle of B. malayi is similar to that of WUCHERERIA BANCROFTI, except that in most areas the principal mosquito vectors belong to the genus Mansonia.

Ordered rearrangement of B-lymphocyte variable gene regions coding for the IMMUNOGLOBULIN CHAINS, thereby contributing to antibody diversity. It occurs during the differentiation of the IMMATURE B-LYMPHOCYTES.

Blood of the fetus. Exchange of nutrients and waste between the fetal and maternal blood occurs via the PLACENTA. The cord blood is blood contained in the umbilical vessels (UMBILICAL CORD) at the time of delivery.

A round-to-oval mass of lymphoid tissue embedded in the lateral wall of the PHARYNX. There is one on each side of the oropharynx in the fauces between the anterior and posterior pillars of the SOFT PALATE.

A technique using antibodies for identifying or quantifying a substance. Usually the substance being studied serves as antigen both in antibody production and in measurement of antibody by the test substance.

Proteins prepared by recombinant DNA technology.

Immunologic techniques involved in diagnosis.

RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.

The major interferon produced by mitogenically or antigenically stimulated LYMPHOCYTES. It is structurally different from TYPE I INTERFERON and its major activity is immunoregulation. It has been implicated in the expression of CLASS II HISTOCOMPATIBILITY ANTIGENS in cells that do not normally produce them, leading to AUTOIMMUNE DISEASES.

A protein present in the cell wall of most Staphylococcus aureus strains. The protein selectively binds to the Fc region of human normal and myeloma-derived IMMUNOGLOBULIN G. It elicits antibody activity and may cause hypersensitivity reactions due to histamine release; has also been used as cell surface antigen marker and in the clinical assessment of B lymphocyte function.

Elements of limited time intervals, contributing to particular results or situations.

Serum that contains antibodies. It is obtained from an animal that has been immunized either by ANTIGEN injection or infection with microorganisms containing the antigen.

The insertion of recombinant DNA molecules from prokaryotic and/or eukaryotic sources into a replicating vehicle, such as a plasmid or virus vector, and the introduction of the resultant hybrid molecules into recipient cells without altering the viability of those cells.

A family of neutral serine proteases with TRYPSIN-like activity. Tryptases are primarily found in the SECRETORY GRANULES of MAST CELLS and are released during mast cell degranulation.

Differentiation antigens residing on mammalian leukocytes. CD stands for cluster of differentiation, which refers to groups of monoclonal antibodies that show similar reactivity with certain subpopulations of antigens of a particular lineage or differentiation stage. The subpopulations of antigens are also known by the same CD designation.

Substances of fungal origin that have antigenic activity.

Test for tissue antigen using either a direct method, by conjugation of antibody with fluorescent dye (FLUORESCENT ANTIBODY TECHNIQUE, DIRECT) or an indirect method, by formation of antigen-antibody complex which is then labeled with fluorescein-conjugated anti-immunoglobulin antibody (FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT). The tissue is then examined by fluorescence microscopy.

Proteins secreted by the prostate gland. The major secretory proteins from the human prostate gland include PROSTATE-SPECIFIC ANTIGEN, prostate-specific acid phosphatase, prostate-specific membrane antigen, and prostate-specific protein-94.

An amine derived by enzymatic decarboxylation of HISTIDINE. It is a powerful stimulant of gastric secretion, a constrictor of bronchial smooth muscle, a vasodilator, and also a centrally acting neurotransmitter.

Conjunctivitis due to hypersensitivity to various allergens.

Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)

A condition characterized by infiltration of the lung with EOSINOPHILS due to inflammation or other disease processes. Major eosinophilic lung diseases are the eosinophilic pneumonias caused by infections, allergens, or toxic agents.

Technique using an instrument system for making, processing, and displaying one or more measurements on individual cells obtained from a cell suspension. Cells are usually stained with one or more fluorescent dyes specific to cell components of interest, e.g., DNA, and fluorescence of each cell is measured as it rapidly transverses the excitation beam (laser or mercury arc lamp). Fluorescence provides a quantitative measure of various biochemical and biophysical properties of the cell, as well as a basis for cell sorting. Other measurable optical parameters include light absorption and light scattering, the latter being applicable to the measurement of cell size, shape, density, granularity, and stain uptake.

Globulins of milk obtained from the WHEY.

Specialized forms of antibody-producing B-LYMPHOCYTES. They synthesize and secrete immunoglobulin. They are found only in lymphoid organs and at sites of immune responses and normally do not circulate in the blood or lymph. (Rosen et al., Dictionary of Immunology, 1989, p169 & Abbas et al., Cellular and Molecular Immunology, 2d ed, p20)

Antibodies that react with self-antigens (AUTOANTIGENS) of the organism that produced them.

Health care professionals, technicians, and assistants staffing LABORATORIES in research or health care facilities.

In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.

Mercury chloride (HgCl2). A highly toxic compound that volatizes slightly at ordinary temperature and appreciably at 100 degrees C. It is corrosive to mucous membranes and used as a topical antiseptic and disinfectant.

The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.

Technique involving the diffusion of antigen or antibody through a semisolid medium, usually agar or agarose gel, with the result being a precipitin reaction.

Genes and gene segments encoding the IMMUNOGLOBULIN LIGHT CHAINS. Gene segments of the light chain genes are designated as V (variable), J (joining), and C (constant).

Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations, or by parent x offspring matings carried out with certain restrictions. All animals within an inbred strain trace back to a common ancestor in the twentieth generation.

Cells artificially created by fusion of activated lymphocytes with neoplastic cells. The resulting hybrid cells are cloned and produce pure MONOCLONAL ANTIBODIES or T-cell products, identical to those produced by the immunologically competent parent cell.

An infant during the first month after birth.

A contact dermatitis due to allergic sensitization to various substances. These substances subsequently produce inflammatory reactions in the skin of those who have acquired hypersensitivity to them as a result of prior exposure.

The ordered rearrangement of gene regions by DNA recombination such as that which occurs normally during development.

Noises, normal and abnormal, heard on auscultation over any part of the RESPIRATORY TRACT.

A species of trematode blood flukes of the family Schistosomatidae. It is common in the Nile delta. The intermediate host is the planorbid snail. This parasite causes schistosomiasis mansoni and intestinal bilharziasis.

Washing liquid obtained from irrigation of the lung, including the BRONCHI and the PULMONARY ALVEOLI. It is generally used to assess biochemical, inflammatory, or infection status of the lung.

An anthelmintic used in most schistosome and many cestode infestations.

The sum of the weight of all the atoms in a molecule.

Ordered rearrangement of B-lymphocyte variable gene regions coding for the kappa or lambda IMMUNOGLOBULIN LIGHT CHAINS, thereby contributing to antibody diversity. It occurs during the second stage of differentiation of the IMMATURE B-LYMPHOCYTES.

A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine).

Syndromes in which there is a deficiency or defect in the mechanisms of immunity, either cellular or humoral.

Substances elaborated by bacteria that have antigenic activity.

A dysgammaglobulinemia characterized by a deficiency of IMMUNOGLOBULIN A.

A plant species of the family FABACEAE that yields edible seeds, the familiar peanuts, which contain protein, oil and lectins.

Insects of the order Dictyoptera comprising several families including Blaberidae, BLATTELLIDAE, Blattidae (containing the American cockroach PERIPLANETA americana), Cryptocercidae, and Polyphagidae.

Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.

Infections with nematodes of the superfamily FILARIOIDEA. The presence of living worms in the body is mainly asymptomatic but the death of adult worms leads to granulomatous inflammation and permanent fibrosis. Organisms of the genus Elaeophora infect wild elk and domestic sheep causing ischemic necrosis of the brain, blindness, and dermatosis of the face.

Proteins isolated from the roots of the pokeweed, Phytolacca americana, that agglutinate some erythrocytes, stimulate mitosis and antibody synthesis in lymphocytes, and induce activation of plasma cells.

Electrophoresis in which a polyacrylamide gel is used as the diffusion medium.

Serum glycoproteins participating in the host defense mechanism of COMPLEMENT ACTIVATION that creates the COMPLEMENT MEMBRANE ATTACK COMPLEX. Included are glycoproteins in the various pathways of complement activation (CLASSICAL COMPLEMENT PATHWAY; ALTERNATIVE COMPLEMENT PATHWAY; and LECTIN COMPLEMENT PATHWAY).

Earth or other matter in fine, dry particles. (Random House Unabridged Dictionary, 2d ed)

Recombinant proteins produced by the GENETIC TRANSLATION of fused genes formed by the combination of NUCLEIC ACID REGULATORY SEQUENCES of one or more genes with the protein coding sequences of one or more genes.

Specific molecular sites on the surface of various cells, including B-lymphocytes and macrophages, that combine with IMMUNOGLOBULIN Gs. Three subclasses exist: Fc gamma RI (the CD64 antigen, a low affinity receptor), Fc gamma RII (the CD32 antigen, a high affinity receptor), and Fc gamma RIII (the CD16 antigen, a low affinity receptor).

Diseases caused by factors involved in one's employment.

Interleukin-8 receptor modulates IgE production and B-cell expansion and trafficking in allergen-induced pulmonary inflammation. (1/5385)

We examined the role of the interleukin-8 (IL-8) receptor in a murine model of allergen-induced pulmonary inflammation using mice with a targeted deletion of the murine IL-8 receptor homologue (IL-8r-/-). Wild-type (Wt) and IL-8r-/- mice were systemically immunized to ovalbumin (OVA) and were exposed with either single or multiple challenge of aerosolized phosphate-buffered saline (OVA/PBS) or OVA (OVA/OVA). Analysis of cells recovered from bronchoalveolar lavage (BAL) revealed a diminished recruitment of neutrophils to the airway lumen after single challenge in IL-8r-/- mice compared with Wt mice, whereas multiply challenged IL-8r-/- mice had increased B cells and fewer neutrophils compared with Wt mice. Both Wt and IL-8r-/- OVA/OVA mice recruited similar numbers of eosinophils to the BAL fluid and exhibited comparable degrees of pulmonary inflammation histologically. Both total and OVA-specific IgE levels were greater in multiply challenged IL-8r-/- OVA/OVA mice than in Wt mice. Both the IL-8r-/- OVA/OVA and OVA/PBS mice were significantly less responsive to methacholine than their respective Wt groups, but both Wt and IL-8r mice showed similar degrees of enhancement after multiple allergen challenge. The data demonstrate that the IL-8r modulates IgE production, airway responsiveness, and the composition of the cells (B cells and neutrophils) recruited to the airway lumen in response to antigen. (+info)

gp49B1 inhibits IgE-initiated mast cell activation through both immunoreceptor tyrosine-based inhibitory motifs, recruitment of src homology 2 domain-containing phosphatase-1, and suppression of early and late calcium mobilization. (2/5385)

We define by molecular, pharmacologic, and physiologic approaches the proximal mechanism by which the immunoglobulin superfamily member gp49B1 inhibits mast cell activation mediated by the high affinity Fc receptor for IgE (FcepsilonRI). In rat basophilic leukemia-2H3 cells expressing transfected mouse gp49B1, mutation of tyrosine to phenylalanine in either of the two immunoreceptor tyrosine-based inhibitory motifs of the gp49B1 cytoplasmic domain partially suppressed gp49B1-mediated inhibition of exocytosis, whereas mutation of both abolished inhibitory capacity. Sodium pervanadate elicited tyrosine phosphorylation of native gp49B1 and association of the tyrosine phosphatases src homology 2 domain-containing phosphatase-1 (SHP-1) and SHP-2 in mouse bone marrow-derived mast cells (mBMMCs). SHP-1 associated transiently with gp49B1 within 1 min after coligation of gp49B1 with cross-linked FcepsilonRI in mBMMCs. SHP-1-deficient mBMMCs exhibited a partial loss of gp49B1-mediated inhibition of FcepsilonRI-induced exocytosis at concentrations of IgE providing optimal exocytosis, revealing a central, but not exclusive, SHP-1 requirement in the counter-regulatory pathway. Coligation of gp49B1 with cross-linked FcepsilonRI on mBMMCs inhibited early release of calcium from intracellular stores and subsequent influx of extracellular calcium, consistent with SHP-1 participation. Because exocytosis is complete within 2 min in mBMMCs, our studies establish a role for SHP-1 in the initial counter-regulatory cellular responses whereby gp49B1 immunoreceptor tyrosine-based inhibition motifs rapidly transmit inhibition of FcepsilonRI-mediated exocytosis. (+info)

Hyper-IgE syndrome with recurrent infections--an autosomal dominant multisystem disorder. (3/5385)

BACKGROUND: The hyper-IgE syndrome with recurrent infections is a rare immunodeficiency characterized by recurrent skin and pulmonary abscesses and extremely elevated levels of IgE in serum. Associated facial and skeletal features have been recognized, but their frequency is unknown, and the genetic basis of the hyper-IgE syndrome is poorly understood. METHODS: We studied 30 patients with the hyper-IgE syndrome and 70 of their relatives. We took histories, reviewed records, performed physical and dental examinations, took anthropometric measurements, and conducted laboratory studies. RESULTS: Nonimmunologic features of the hyper-IgE syndrome were present in all patients older than eight years. Seventy-two percent had the previously unrecognized feature of failure or delay of shedding of the primary teeth owing to lack of root resorption. Common findings among patients were recurrent fractures (in 57 percent of patients), hyperextensible joints (in 68 percent), and scoliosis (in 76 percent of patients 16 years of age or older). The classic triad of abscesses, pneumonia, and an elevated IgE level was identified in 77 percent of all patients and in 85 percent of those older than eight. In 6 of 23 adults (26 percent), IgE levels declined over time and came closer to or fell within the normal range. Autosomal dominant transmission of the hyper-IgE syndrome was found, but with variable expressivity. Of the 27 relatives at risk for inheriting the hyper-IgE syndrome, 10 were fully affected, 11 were unaffected, and 6 had combinations of mild immunologic, dental, and skeletal features of the hyper-IgE syndrome. CONCLUSIONS: The hyper-IgE syndrome is a multisystem disorder that affects the dentition, the skeleton, connective tissue, and the immune system. It is inherited as a single-locus autosomal dominant trait with variable expressivity. (+info)

Exhaled and nasal NO levels in allergic rhinitis: relation to sensitization, pollen season and bronchial hyperresponsiveness. (4/5385)

Exhaled nitric oxide is a potential marker of lower airway inflammation. Allergic rhinitis is associated with asthma and bronchial hyperresponsiveness. To determine whether or not nasal and exhaled NO concentrations are increased in allergic rhinitis and to assess the relation between hyperresponsiveness and exhaled NO, 46 rhinitic and 12 control subjects, all nonasthmatic nonsmokers without upper respiratory tract infection, were randomly selected from a large-scale epidemiological survey in Central Norway. All were investigated with flow-volume spirometry, methacholine provocation test, allergy testing and measurement of nasal and exhaled NO concentration in the nonpollen season. Eighteen rhinitic subjects completed an identical follow-up investigation during the following pollen season. Exhaled NO was significantly elevated in allergic rhinitis in the nonpollen season, especially in perennially sensitized subjects, as compared with controls (p=0.01), and increased further in the pollen season (p=0.04), mainly due to a two-fold increase in those with seasonal sensitization. Nasal NO was not significantly different from controls in the nonpollen season and did not increase significantly in the pollen season. Exhaled NO was increased in hyperresponsive subjects, and decreased significantly after methacholine-induced bronchoconstriction, suggesting that NO production occurs in the peripheral airways. In allergic rhinitis, an increase in exhaled nitric oxide on allergen exposure, particularly in hyperresponsive subjects, may be suggestive of airway inflammation and an increased risk for developing asthma. (+info)

Immunosurveillance of alglucerase enzyme therapy for Gaucher patients: induction of humoral tolerance in seroconverted patients after repeat administration. (5/5385)

Alglucerase, a macrophage-targeted enzyme replacement therapy for Gaucher disease, has been successfully used for several years to improve clinical symptoms and reverse disease progression. As part of an immunosurveillance program, 1,122 Gaucher patients were monitored for antibody response to glucocerebrosidase, the active component of alglucerase. Seroconversion was detected in 142 patients (12.8%) by enzyme-linked immunosorbent assay (ELISA) and confirmed by radioimmunoprecipitation. The majority (75%) of the seroconverted population had no detectable levels of circulating inhibitory antibody as assessed by in vitro inhibition of enzymatic activity of the therapeutic molecule. Of the remaining patients with putative inhibitory antibodies, the majority had only low levels of serum inhibitory activity, which was transient. A very small number of patients were identified as developing true neutralizing antibodies, as defined by the development of antibodies that impacted clinical efficacy. Many of the patient antibody responses were also diminished with time. Eighty-two of the 142 seroconverted patients have stopped producing antibody to the molecule and appear tolerized. The mean time for humoral tolerization was 28 months from initiation of therapy. Of 64 seroconverted patients followed for at least 30 months of therapy, the tolerization rate was 93%. These results show that although 12.8% of the patients on therapy developed antibodies to the molecule, 90% of these patients became tolerized over time. (+info)

Involvement of tachykinin receptors in sensitisation to cow's milk proteins in guinea pigs. (6/5385)

BACKGROUND: There is growing evidence for a pivotal role for tachykinins in gut neuroimmune interactions. AIMS: To determine whether NK1, NK2, and NK3 tachykinin receptors are involved in milk protein induced allergic sensitisation. METHODS: Eight groups of 12 Dunkin-Hartley guinea pigs (250-300 g) were used. Four groups were sensitised to milk proteins for three weeks. During this period, these animals were injected intraperitoneally each day with NK1 (SR 140333; 0.3 mg/kg), NK2 (SR 48968; 5 mg/kg), or NK3 (SR 142801; 5 mg/kg) receptor antagonist or vehicle. The fifth group had water available instead of milk and was used as a non-sensitised control. The three other groups received the NK receptor antagonists for three weeks but were not sensitised to milk proteins. RESULTS: Sensitised animals treated with NK1 and NK3 receptor antagonists had both lower IgE and IgG serum titres, evaluated by passive cutaneous anaphylaxis, and lower specific IgG serum titres, determined by enzyme linked immunosorbent assay (ELISA), than vehicle treated animals. Sensitisation induced an increase in intestinal mast cell number which was abolished by treatment with the NK1 receptor antagonist. Antigenic challenge-induced jejunal hypersecretion was also blocked by treatment with the NK1 receptor antagonist. CONCLUSION: In guinea pigs, NK1 and NK3 but not NK2 receptors are involved in sensitisation to cow's milk. However, NK1 but not NK3 receptor antagonists abolish both the hypermastocytosis induced by food allergy and the hypersecretion induced by antigenic challenge, suggesting different roles for NK1 and NK3 receptors in the mechanisms of sensitisation to beta-lactoglobulin. (+info)

Induction of Ig somatic hypermutation and class switching in a human monoclonal IgM+ IgD+ B cell line in vitro: definition of the requirements and modalities of hypermutation. (7/5385)

Partly because of the lack of a suitable in vitro model, the trigger(s) and the mechanism(s) of somatic hypermutation in Ig genes are largely unknown. We have analyzed the hypermutation potential of human CL-01 lymphocytes, our monoclonal model of germinal center B cell differentiation. These cells are surface IgM+ IgD+ and, in the absence of T cells, switch to IgG, IgA, and IgE in response to CD40:CD40 ligand engagement and exposure to appropriate cytokines. We show here that CL-01 cells can be induced to effectively mutate the expressed VHDJH-C mu, VHDJH-C delta, VHDJH-C gamma, VHDJH-C alpha, VHDJH-C epsilon, and V lambda J lambda-C lambda transcripts before and after Ig class switching in a stepwise fashion. In these cells, induction of somatic mutations required cross-linking of the surface receptor for Ag and T cell contact through CD40:CD40 ligand and CD80: CD28 coengagement. The induced mutations showed intrinsic features of Ig V(D)J hypermutation in that they comprised 110 base substitutions (97 in the heavy chain and 13 in the lambda-chain) and only 2 deletions and targeted V(D)J, virtually sparing CH and C lambda. These mutations were more abundant in secondary VHDJH-C gamma than primary VHDJH-C mu transcripts and in V(D)J-C than V lambda J lambda-C lambda transcripts. These mutations were also associated with coding DNA strand polarity and showed an overall rate of 2.42 x 10(-4) base changes/cell division in VHDJH-CH transcripts. Transitions were favored over transversions, and G nucleotides were preferentially targeted, mainly in the context of AG dinucleotides. Thus, in CL-01 cells, Ig somatic hypermutation is readily inducible by stimuli different from those required for class switching and displays discrete base substitution modalities. (+info)

Evidence for the involvement of IgE-basophil system in acute serum sickness. (8/5385)

The role of the basophils in acute serum sickness of rabbits was examined by monitoring daily the absolute number of basophils before, during and after the disease period. After antigen (bovine serum albumin, BSA) elimination, levels of serum IgE and in vitro basophil degranulation in the presence of BSA were determined. The results showed that the onset of glomerular lesions depends upon the simultaneous occurrence of circulating immune complexes greater than 19 S and of an in vivo basophil depletion--probably equivalent to degranulation--reaching 70% of the pre-disease number. Post-disease antigen-dependent in vitro degranulation of the basophils and levels of serum IgE anti BSA did not prove to be good indexes of basophil sensitization. Our data suggest that basophils are instrumental at early stages of the deposition of immune complexes, most probably through their sensitization by membrane-bound IgE antibodies. (+info)

... (Ig G) is a type of antibody. Representing approximately 75% of serum antibodies in humans, IgG is the most ... This repertoire of immunoglobulins is crucial for the newborns who are very sensitive to infections, especially within the ... Stadlmann J, Pabst M, Kolarich D, Kunert R, Altmann F (2008). "Analysis of immunoglobulin glycosylation by LC-ESI-MS of ... de Haan, Noortje; Falck, David; Wuhrer, Manfred (2019-07-08). "Monitoring of Immunoglobulin N- and O-glycosylation in Health ...

https://en.wikipedia.org/wiki/Immunoglobulin_G

Immunodeficiency with hyper-immunoglobulin M Immunoglobulin M deficiency Immune system "Immunoglobulin M". The American ... Immunoglobulin M (IgM) is one of several isotypes of antibody (also known as immunoglobulin) that are produced by vertebrates. ... Immunoglobulin+M at the US National Library of Medicine Medical Subject Headings (MeSH) Immunoglobulin M Deficiency Reference ... Mestecky, J.; Zikin, J.; Butler, W. T. (1971). "Immunoglobulin M an secretory immunoglobulin A: presence of common polypeptide ...

https://en.wikipedia.org/wiki/Immunoglobulin_M

... human normal immunoglobulin), and Flebogamma DIF (human normal immunoglobulin). In the EU human normal immunoglobulin (SCIg) ( ... Some believe that immunoglobulin therapy may work via a multi-step model where the injected immunoglobulin first forms a type ... Immunoglobulin therapy is the use of a mixture of antibodies (normal human immunoglobulin or NHIG) to treat several health ... Human normal immunoglobulin (human immunoglobulin G) (Cutaquig) was approved for medical use in Australia in May 2021. Brands ...

https://en.wikipedia.org/wiki/Immunoglobulin_therapy

Specifically, anti-immunoglobulin antibodies bind to immunoglobulins that are created by B cells. Anti-immunoglobulin ... The anti-immunoglobulin antibodies are created through recombinant DNA technology. All anti-immunoglobulin antibodies are man- ... Kappa light chains are the second of the two classes of light chains present on mammalian immunoglobulins. One immunoglobulin ... The most practical use for anti-immunoglobulin antibodies is in diagnostic tests. Assays use anti-immunoglobulin antibodies to ...

https://en.wikipedia.org/wiki/Anti-immunoglobulin

... (Ig A, also referred to as sIgA in its secretory form) is an antibody that plays a role in the immune function ... Immunoglobulin+A at the US National Library of Medicine Medical Subject Headings (MeSH) Herich, R. (2017). "Is the role of IgA ... The IgA dimeric form is the most prevalent and is also called secretory IgA (sIgA). sIgA is the main immunoglobulin found in ... This represents up to 15% of total immunoglobulins produced throughout the body. IgA has two subclasses (IgA1 and IgA2) and can ...

https://en.wikipedia.org/wiki/Immunoglobulin_A

... (IgD) is an antibody isotype that makes up about 1% of proteins in the plasma membranes of immature B- ... Immunoglobulin+D at the US National Library of Medicine Medical Subject Headings (MeSH) (CS1 maint: uses authors parameter, All ... Rogentine GN, Rowe DS, Bradley J, Waldmann TA, Fahey JL (1966). "Metabolism of human immunoglobulin D (IgD)". J. Clin. Invest. ... Nitschke L, Kosco MH, Köhler G, Lamers MC (1993). "Immunoglobulin D-deficient mice can mount normal immune responses to thymus- ...

https://en.wikipedia.org/wiki/Immunoglobulin_D

The immunoglobulin domain, also known as the immunoglobulin fold, is a type of protein domain that consists of a 2-layer ... SCOP listing of immunoglobulin domains of known structure This article incorporates text from the public domain Pfam and ... Immunoglobulin-like domains may be involved in protein-protein and protein-ligand interactions. Human genes encoding proteins ... Members of the immunoglobulin superfamily are found in hundreds of proteins of different functions. Examples include antibodies ...

https://en.wikipedia.org/wiki/Immunoglobulin_domain

... is expensive and hard to come by in the developing world. In the United States it is estimated to be more ... Rabies immunoglobulin (RIG) is a medication made up of antibodies against the rabies virus. It is used to prevent rabies ... The use of rabies immunoglobulin in the form of blood serum dates from 1891. Use became common within medicine in the 1950s. It ... Rabies immunoglobulin (RIG) is indicated for the passive, transient post-exposure prophylaxis of rabies infection, when given ...

https://en.wikipedia.org/wiki/Rabies_immunoglobulin

... (IgE) is a type of antibody (or immunoglobulin (Ig) "isotype") that has been found only in mammals. IgE is ... November 2013). "A beneficial role for immunoglobulin E in host defense against honeybee venom". Immunity. 39 (5): 963-75. doi: ... Presence of a unique immunoglobulin as a carrier of reaginic activity". Journal of Immunology. 97 (1): 75-85. PMID 4162440. ... Winter WE, Hardt NS, Fuhrman S (September 2000). "Immunoglobulin E: importance in parasitic infections and hypersensitivity ...

https://en.wikipedia.org/wiki/Immunoglobulin_E

The immunoglobulin superfamily (IgSF) is a large protein superfamily of cell surface and soluble proteins that are involved in ... Proteins of the IgSF possess a structural domain known as an immunoglobulin (Ig) domain. Ig domains are named after the ... Otherwise, the sperm-specific protein IZUMO1, a member of the immunoglobulin superfamily, has also been identified as the only ... Harpaz Y, Chothia C (May 1994). "Many of the immunoglobulin superfamily domains in cell adhesion molecules and surface ...

https://en.wikipedia.org/wiki/Immunoglobulin_superfamily

In chickens, immunoglobulin Y is the functional equivalent to Immunoglobulin G (IgG). Like IgG, it is composed of two light and ... Immunoglobulin Y (abbreviated as IgY) is a type of immunoglobulin which is the major antibody in bird, reptile, and lungfish ... Thus, in preparations from chicken eggs, there is no contamination with Immunoglobulin A (IgA) or Immunoglobulin M (IgM). The ... after they were able to show differences between the immunoglobulins found in chicken eggs, and immunoglobulin G. Other ...

https://en.wikipedia.org/wiki/Immunoglobulin_Y

... (BiP) also known as 78 kDa glucose-regulated protein (GRP-78) or heat shock 70 kDa protein 5 ( ... GRP78 (HSPA5), also referred to as 'immunoglobulin heavy chain-binding protein' (BiP), is a member of the heat-shock protein-70 ... Corrigall VM, Vittecoq O, Panayi GS (October 2009). "Binding immunoglobulin protein-treated peripheral blood monocyte-derived ...

https://en.wikipedia.org/wiki/Binding_immunoglobulin_protein

Naïve mature B cells produce both IgM and IgD, which are the first two heavy chain segments in the immunoglobulin locus. After ... Immunoglobulin+class+switching at the US National Library of Medicine Medical Subject Headings (MeSH) (Articles with short ... Immunoglobulin class switching, also known as isotype switching, isotypic commutation or class-switch recombination (CSR), is a ... Laffleur B, Bardet SM, Garot A, Brousse M, Baylet A, Cogné M (2014). "Immunoglobulin genes undergo legitimate repair in human B ...

https://en.wikipedia.org/wiki/Immunoglobulin_class_switching

The immunoglobulin is categorized as immunoglobulin G (IgG). Since the tetanus toxin permanently binds to human tissues, only ... Anti-tetanus immunoglobulin, also known as tetanus immune globulin (TIG) and tetanus antitoxin, is a medication made up of ... unbounded molecules can be neutralized by the immunoglobulin. Use of the horse version became common in the 1910s, while the ...

https://en.wikipedia.org/wiki/Anti-tetanus_immunoglobulin

The immunoglobulin light chain is the small polypeptide subunit of an antibody (immunoglobulin). A typical antibody is composed ... The immunoglobulin light chain genes in tetrapods can be classified into three distinct groups: kappa (κ), lambda (λ), and ... Immunoglobulin+Light+Chains at the US National Library of Medicine Medical Subject Headings (MeSH) Educational Resource for ... There are two types of light chain in humans: kappa (κ) chain, encoded by the immunoglobulin kappa locus ([email protected]) on chromosome 2 ...

https://en.wikipedia.org/wiki/Immunoglobulin_light_chain

pIgR has a strong specificity to polymeric immunoglobulins and is not responsive to monomeric immunoglobulin. The ligand's J- ... "Entrez Gene: PIGR polymeric immunoglobulin receptor". Kaetzel CS (August 2005). "The polymeric immunoglobulin receptor: ... Polymeric immunoglobulin receptor (pIgR) is a transmembrane protein that in humans is encoded by the PIGR gene. It is an Fc ... Polymeric+Immunoglobulin+Receptor at the US National Library of Medicine Medical Subject Headings (MeSH) Portal: Biology This ...

https://en.wikipedia.org/wiki/Polymeric_immunoglobulin_receptor

The immunoglobulin heavy chain (IgH) is the large polypeptide subunit of an antibody (immunoglobulin). In human genome, the IgH ... There are five types of mammalian immunoglobulin heavy chain: γ, δ, α, μ and ε. They define classes of immunoglobulins: IgG, ... Each heavy chain has two regions: a constant region (which is the same for all immunoglobulins of the same class but differs ... a variable region that differs between different B cells, but is the same for all immunoglobulins produced by the same B cell ...

https://en.wikipedia.org/wiki/Immunoglobulin_heavy_chain

... , or sometimes Immunoglobulin binding protein is a generic name for any protein that binds ... Immunoglobulin-binding protein 1 (IGBP1), a protein that binds B-cells in the blood. Protein A, a 42 kDa protein originally ... It, therefore, can mean: Binding immunoglobulin protein (BiP, or heat shock 70 kDa protein 5, with an official symbol HSPA5), a ...

https://en.wikipedia.org/wiki/Immunoglobulin-binding_protein

V-set domains are found in diverse protein families, including immunoglobulin light and heavy chains; in several T-cell ... "Phosphocholine binding immunoglobulin Fab McPC603. An X-ray diffraction study at 2.7 A". J. Mol. Biol. 190 (4): 593-604. doi: ... Immunoglobulin V-set, subgroup InterPro: IPR003596 T-cell surface antigen CD2 InterPro: IPR013285 ACAM; ACAN; ADAMTSL1; AGC1; ...

https://en.wikipedia.org/wiki/Immunoglobulin_V-set_domain

The underlying cause of MIDD is the production of monoclonal immunoglobulins. Monoclonal immunoglobulins are produced in ... The immunoglobulin heavy chain in HCDD is frequently a truncated heavy chain. HCDD is the rarest subtype of MIDD. Serum protein ... Monoclonal immunoglobulins are produced by monoclonal plasma cells, which are found in a variety of plasma cell dyscrasias. The ... Monoclonal Immunoglobulin Deposition Disorder, or MIDD, is a disease characterised by the deposition of monoclonal ...

https://en.wikipedia.org/wiki/Monoclonal_Immunoglobulin_Deposition_Disorder

MAdCAM-1 belongs to a subclass of the immunoglobulin superfamily (IgSF), the members of which are ligands for integrins. The ... In molecular biology, the adhesin molecule (immunoglobulin-like) is a protein domain. This domain is found in mucosal vascular ... "The structure of immunoglobulin superfamily domains 1 and 2 of MAdCAM-1 reveals novel features important for integrin ... crystal structure of this domain has been reported; it adopts an immunoglobulin-like beta-sandwich structure, with seven ...

https://en.wikipedia.org/wiki/Adhesion_molecule_(immunoglobulin-like)

Selective immunoglobulin A (IgA) deficiency (SIgAD) is a genetic immunodeficiency, a type of hypogammaglobulinemia. People with ... They rarely present with severe reactions, including anaphylaxis, to blood transfusions or intravenous immunoglobulin due to ... There is an inherited inability to produce immunoglobulin A (IgA), a part of the body's defenses against infection at the ... There is a historical popularity in using intravenous immunoglobulin (IVIG) to treat SIgAD, but the consensus is that there is ...

https://en.wikipedia.org/wiki/Selective_immunoglobulin_A_deficiency

I-set domains are found in several cell adhesion molecules, including vascular (VCAM), intercellular (ICAM), neural (NCAM) and mucosal addressin (MADCAM) cell adhesion molecules, as well as junction adhesion molecules (JAM). I-set domains are also present in several other diverse protein families, including several tyrosine-protein kinase receptors, the hemolymph protein hemolin, the muscle proteins titin, telokin, and twitchin, the neuronal adhesion molecule axonin-1, and the signalling molecule semaphorin 4D that is involved in axonal guidance, immune function and angiogenesis. ADAMTSL1, ADAMTSL3, ALPK3, AXL, BOC, C9orf94, CADM2, CADM4, CCDC141, CDON, CEACAM7, CHL1, CILP2, CNTN1, CNTN2, CNTN3, CNTN4, CNTN5, CNTN6, CXADR, DCC, DSCAM, DSCAML1, ESAM, FGFR1, FGFR3, FGFR4, FGFRL1, FLT1, FLT4, FSTL4, FSTL5, HMCN1, HNT, HSPG2, ICAM5, IGFBP7, IGFBPL1, IGSF10, IGSF22, IGSF9, ISLR, KALRN, KAZALD1, KDR, KIAA0626, KIRREL, KIRREL2, KIRREL3, L1CAM, LINGO1, LINGO2, LRFN2, LRFN3, LRFN4, LRFN5, LRIG1, LRIG2, ...

https://en.wikipedia.org/wiki/Immunoglobulin_I-set_domain

The leukocyte immunoglobulin-like receptors (LILR) are a family of receptors possessing extracellular immunoglobulin domains. ... LAIR1 Killer-cell immunoglobulin-like receptor David E. Sloane; Nicodemus Tedla; Muyiwa Awoniyi; Donald W. MacGlashan Jr.; Luis ... v t e v t e v t e (Protein pages needing a picture, Immunoglobulin superfamily, All stub articles, Biochemistry stubs, Receptor ... Borges; K. Frank Austen; Jonathan P. Arm (November 2004). "Leukocyte immunoglobulin-like receptors: novel innate receptors for ...

https://en.wikipedia.org/wiki/Leukocyte_immunoglobulin-like_receptors

... is a protein that in humans is encoded by the IGSF3 gene. The protein encoded by this gene ... "Entrez Gene: Immunoglobulin superfamily member 3". Retrieved 2018-10-06. v t e This article incorporates text from the United ... is an immunoglobulin-like membrane protein containing several V-type Ig-like domains. A mutation in this gene has been ...

https://en.wikipedia.org/wiki/Immunoglobulin_superfamily_member_3

C1-set domains are found almost exclusively in molecules involved in the immune system, such as in immunoglobulin light and ...

https://en.wikipedia.org/wiki/Immunoglobulin_C1-set_domain

CD2 CD4 VCAM1 Smith DK, Xue H (1997). "Sequence profiles of immunoglobulin and immunoglobulin-like domains". J. Mol. Biol. 274 ... Immunoglobulin-like domains that are related in both sequence and structure can be found in several diverse protein families. ... CD4 is the primary receptor for HIV-1. CD4 has four immunoglobulin-like domains in its extracellular region that share the same ... The basic structure of immunoglobulin (Ig) molecules is a tetramer of two light chains and two heavy chains linked by ...

https://en.wikipedia.org/wiki/Immunoglobulin_C2-set_domain

... (TIM) proteins are a family of cell surface immunomodulatory proteins. TIM1 Kane ...

https://en.wikipedia.org/wiki/Transmembrane_immunoglobulin_and_munin_domain

Members of the IgSF family include the human killer cell immunoglobulin-like receptor (KIR) and the Immunoglobulin-like ... includes immunoglobulin-like transcripts (ILT, also known as leukocyte immunoglobulin-like receptors (LIRs)), leukocyte- ... Human killer cell immunoglobulin-like receptors recognize the α1 and α2 domains of class I human leukocyte antigens (HLA-A, -B ... Killer-cell immunoglobulin-like receptors (KIRs), are a family of type I transmembrane glycoproteins expressed on the plasma ...

https://en.wikipedia.org/wiki/Killer-cell_immunoglobulin-like_receptor

... is a immunoglobulin gene with symbol IGHA1. It encodes a constant (C) segment of ... Immunoglobulin A is an antibody that plays a critical role in immune function in the mucous membranes. IgA shows the same ... "Entrez Gene: IGHA1 immunoglobulin heavy constant alpha 1". Kratzin, H.; Altevogt, P.; Ruban, E.; Kortt, A.; Staroscik, K.; ... "IGHA1 immunoglobulin heavy constant alpha 1 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2016-10-16 ...

https://en.wikipedia.org/wiki/Immunoglobulin_heavy_constant_alpha_1

Total immunoglobulin A deficiency (IgAD) is defined as an undetectable serum immunoglobulin A (IgA) level at a value < 5 mg/dL ... Selective immunoglobulin A deficiency (SIgAD) is a primary immunodeficiency disease and is the most common of the primary ... 1] Total immunoglobulin A deficiency (IgAD) is defined as an undetectable serum immunoglobulin A (IgA) level at a value , 5 mg/ ... encoded search term (Immunoglobulin A Deficiency) and Immunoglobulin A Deficiency What to Read Next on Medscape ...

https://www.medscape.com/answers/136580-114042/what-is-the-molecular-analysis-of-b-cell-differentiation-in-patients-with-immunoglobulin-a-deficiency-igad

The specificity of immunoglobulin G and immunoglobulin M in the fluorescent antibody test for malaria parasites in mice / by F ... Evaluation of commercially available anti-dengue virus immunoglobulin M tests Pediatric Dengue Vaccine Initiative; UNICEF/ ... Reversed enzyme-linked immunosorbent assay for detection of specific anti-Plasmodium falciparum immunoglobulin M antibodies / M ...

https://apps.who.int:80/iris/browse?locale-attribute=ar&type=mesh&authority=Immunoglobulin+M

IgG stands for immunoglobulin G. It is a type of antibody. Antibodies are proteins that your immune system makes to fight germs ... URL of this page: https://medlineplus.gov/lab-tests/csf-immunoglobulin-g-igg-index/ CSF Immunoglobulin G (IgG) Index. ... Other names: cerebrospinal fluid IgG level, cerebrospinal fluid IgG measurement, CSF IgG level, IgG (Immunoglobulin G) spinal ... Immunoglobulin G Index; [cited 2022 May 24]; [about 4 screens]. Available from: https://www.labcorp.com/tests/002238/ ...

https://medlineplus.gov/lab-tests/csf-immunoglobulin-g-igg-index/

... immunoglobulin G (IgG), immunoglobulin A (IgA), immunoglobulin M (IgM), immunoglobulin D (IgD), and immunoglobulin E (IgE). The ... Serum immunoglobulin and immunoglobulin G subclasses in children with allergic colitis. West Afr J Med. 1998 Jul-Sep. 17(3):206 ... Immunoglobulin G deficiency. Changes in serum immunoglobulin G concentrations during infancy and childhood. View Media Gallery ... encoded search term (Immunoglobulin G Deficiency) and Immunoglobulin G Deficiency What to Read Next on Medscape ...

http://emedicine.medscape.com/article/136897-overview

FIGURE 1. Number of specimens (N = 568) testing positive for West Nile virus immunoglobulin M antibodies, using one lot from a ... FIGURE 2. Number of persons (N = 518) testing positive for West Nile virus immunoglobulin M antibodies using one lot from a ... Alternative Text: The figure above shows the 568 specimens testing positive for West Nile virus immunoglobulin M antibodies, ... False-Positive Results with a Commercially Available West Nile Virus Immunoglobulin M Assay --- United States, 2008. In ...

https://www.cdc.gov/mmwr/preview/mmwrhtml/mm5817a2.htm

https://extranet.who.int/iris/restricted/browse?locale-attribute=ar&type=mesh&authority=Immunoglobulin+M

... and switching from intravenous immunoglobulin (IVIG) to subcutaneous immunoglobulin (SCIG) can minimize these adverse effects. ... and switching from intravenous immunoglobulin (IVIG) to subcutaneous immunoglobulin (SCIG) can minimize these adverse effects. ... Although a large number of clinical trials have demonstrated that immunoglobulin is effective and well tolerated, various ... Although a large number of clinical trials have demonstrated that immunoglobulin is effective and well tolerated, various ...

https://www.frontiersin.org/articles/10.3389/fimmu.2018.01299/full

E-mail your company news at:. news (at) financial.ge Letters to the Editor: editor (at) finchannel.com. Local Marketing contact:. (+99532) 2252 275 , 76 EXT: 1 (+995 558) 03 03 03 (mobile) marketing (at) finchannel.com. Requests from abroad:. (+99532) 2252 275 , 76 EXT: 7 (+995599) 96 52 52 Email: zviadi (@) finchannel.com Contact video editor: E-mail: video (at) financial.ge. Postal address: 17 Mtskheta str. Tbilisi, Georgia 0179 The FINANCIAL ...

https://finchannel.com/tag/anti-coronavirus-immunoglobulin/

Antibodies (also called immunoglobulins) are proteins the immune system makes to recognize and get rid of germs. ... An IgA test measures the blood level of immunoglobulin A, one of the most common types of antibodies in the body. ...

https://www.kidshealth.org/InteractiveHealth/en/parents/test-iga.html?WT.ac=p-ra

immunoglobulin lambda constant 7provided by HGNC. Primary source. HGNC:HGNC:5861 See related. Ensembl:ENSG00000211685 IMGT/GENE ... Structure and expression of the human immunoglobulin lambda genes. Vasicek TJ, et al. J Exp Med, 1990 Aug 1. PMID 2115572, Free ... part_of immunoglobulin complex, circulating IBA Inferred from Biological aspect of Ancestor. more info ... Recognition of immunoglobulins by Fcgamma receptors. Radaev S, et al. Mol Immunol, 2002 May. PMID 11955599 ...

https://www.ncbi.nlm.nih.gov/gene/28834

High-throughput sequencing analysis of hypermutating immunoglobulin (IG) repertoires remains a challenging task. Here we ... This protocol enables high-throughput sequencing analysis of the full-length immunoglobulin repertoires in human and mouse ... High-quality full-length immunoglobulin profiling with unique molecular barcoding. *M A Turchaninova1,2,3 na1, ... Onset of immune senescence defined by unbiased pyrosequencing of human immunoglobulin mRNA repertoires. PLoS One 7, e49774 ( ...

https://www.nature.com/articles/nprot.2016.093?error=cookies_not_supported&code=d8c02869-7986-49a0-b82a-bf95ddd28dcf

On this page about Hepatitis B Immunoglobulin-VF (CSL) you will find information relating to side effects, age restrictions, ... Other medicines containing the same active ingredients: hepatitis b virus immunoglobulin *Can I take Hepatitis B Immunoglobulin ... Brand name: Hepatitis B Immunoglobulin-VF (CSL) TM. Active ingredients: hepatitis b virus immunoglobulin ... Hepatitis B Immunoglobulin-VF is indicated for post-exposure prophylaxis in persons who did not receive prior vaccination, or ...

https://www.healthdirect.gov.au/medicines/brand/amt,10641000168101/hepatitis-b-immunoglobulin-vf-csl

KEY FINDINGS The global immunoglobulin market is anticipated to rise with a CAGR of 6.87% across the forecast years of 2022 to ... subsequently increasing the need for immunoglobulin products for their treatment.. REGIONAL INSIGHTS. The global immunoglobulin ... The global immunoglobulin market is anticipated to rise with a CAGR of 6.87% across the forecast years of 2022 to 2030. The ... Immunoglobulins are characterized as antibodies that are produced naturally by the bodys immune system.They primarily help ...

https://www.reportlinker.com/p06289643/GLOBAL-IMMUNOGLOBULIN-MARKET-FORECAST.html

The role of complement in immunoglobulin G-triggered inflammation was studied in mice genetically deficient in complement ... Immunoglobulin G-mediated inflammatory responses develop normally in complement-deficient mice J Exp Med. 1996 Dec 1;184(6): ... The role of complement in immunoglobulin G-triggered inflammation was studied in mice genetically deficient in complement ...

https://pubmed.ncbi.nlm.nih.gov/8976192/

... Classification & external resources The dimeric IgA ... Selective immunoglobulin A (IgA) deficiency is a relatively mild genetic immunodeficiency. People with this deficiency lack ... It uses material from the Wikipedia article "Selective_immunoglobulin_A_deficiency". A list of authors is available in ... There is an inherited inability to produce immunoglobulin A (IgA), a part of the bodys defenses against infection at the ...

https://www.bionity.com/en/encyclopedia/Selective_immunoglobulin_A_deficiency.html

US-10287315-B2 chemical patent summary.

https://pubchem.ncbi.nlm.nih.gov/patent/US-10287315-B2

Immunoglobulin (IgE). Many people have allergy-induced asthma, which means that their asthma symptoms are triggered by allergic ... These people have high levels of an allergy-causing antibody (a type of immune protein in the body) called immunoglobulin E ( ...

https://www.teenshealth.org/en/teens/immunoglobulin.html

Mouse IgG and IgA, with reactivity to dinitrophenol conjugated to carrier protein, have been isolated from myeloma proteins by means of a variety of affinity techniques. The IgA was predominantly in the dimeric form. The in vitro and in vivo biological activities of IgA-containing immune complexes were assessed in the rat. IgA-containing immune complexes were demonstrated, in a dose-dependent manner in vitro, to activate neutrophils and to generate O.-2. In addition, these immune complexes showed evidence of complement activation in vitro, by the use of immunofixation techniques. When IgA was instilled into the airways of rats and antigen was injected intravenously, acute lung injury occurred, as reflected by increases in lung permeability and morphological changes consisting of blebbing of endothelial cells, intra-alveolar hemorrhage, and fibrin deposition. The lung changes were directly proportional to the amount of IgA instilled into the airways and failed to occur if intravenous injection of ...

https://www.jci.org/articles/view/111431/scanned-page/366

As a result of this decision, all stock of Octagam intravenous immunoglobulin solutions in Australia will be recalled ... Adequate supplies of alternative intravenous immunoglobulin solution products are available for clinical use in Australia, and ... Doctors should cease using Octagam intravenous immunoglobulin solutions immediately, and switch their patients to the most ... an intravenous immunoglobulin (IVIg) preparation, manufactured by Octapharma in Europe. This product is supplied in Australia ...

https://www.tga.gov.au/octagam-intravenous-immunoglobulin-solutions

PeproTech the producer of high quality recombinant cytokines and growth factors supports life science research, cellular therapy and regenerative medicine.

https://www.peprotech.com/es/normal-mouse-igg

J:5763 Warner NL, et al., Allotypes of mouse IgM immunoglobulin. Nature. 1977 Feb 3;265(5593):447-9 ...

http://www.informatics.jax.org/marker/MGI:96448

The largest anibodies and the first to respomd to infections. ...

https://www.mitoaction.org/glossary/immunoglobulin-igm/

Immunoglobulin A (IgA) is the main effector of the mucosal immune system and provides an important first line of defense ... Mucosal immunoglobulins. Immunol Rev. 64-82. Review.. 2. Woof JM. & Kerr MA., 2007. The function of immunoglobulin A in ... Immunoglobulin A (IgA). Secretory IgA and the mucosal immune system. The mucosal surfaces represent the largest area of ... Immunoglobulin A (IgA), in its secretory form, is the main effector of the mucosal immune system and provides an important ...

https://www.invivogen.com/review-iga

Intravenous Immunoglobulins (IVIGs). Intravenous Immunoglobulins (IVIGs) may be used to control SLE with organ involvement or ... See Patient Information Sheet on Intravenous Immunoglobulins (IVIGs). Source: National Institutes of Health, U.S.Dept of Health ... https://theodora.com/lupus_central_station/intravenous_immunoglobulins_ivigs.html Copyright © 1995-2021 Photius Coutsoukis (All ...

https://theodora.com/lupus_central_station/intravenous_immunoglobulins_ivigs.html

News related to Gammaplex (Human Immunoglobulin G) and/or conditions it is approved for. Human Immunodeficiency Virus (HIV) ...

http://www.druglib.com/druginfo/gammaplex/news/

Immunoglobulins. gamma-Globulins. Immunoglobulins, Intravenous. Rho(D) Immune Globulin. Immunologic Factors. Physiological ... Intravenous Immunoglobulin (IVIG) for Treatment of Unexplained Secondary Recurrent Miscarriage. The safety and scientific ... This clinical study will evaluate the effectiveness of intravenous immunoglobulin (IVIG) in improving the live birth rate in ... Intravenous Immunoglobulin (IVIG) for Treatment of Unexplained Secondary Recurrent Miscarriage: A Prospective, Randomized, ...

https://clinicaltrials.gov/show/NCT00606905

According to the European Medicines Agency guideline on environmental risk assessments for pharmaceuticals (EMA/CHMP/SWP/4447/00), vitamins, electrolytes, amino acids, peptides, proteins, carbohydrates, lipids proteins, vaccines and herbal medicinal products are exempted because they are unlikely to result in significant risk to the environment. ...

https://janusinfo.se/beslutsstod/lakemedelochmiljo/pharmaceuticalsandenvironment/databaseenven/antidimmunoglobulinhuman.5.30a7505616a041a09b063146.html

More info for Fold b.1: Immunoglobulin-like beta-sandwich. Timeline for Fold b.1: Immunoglobulin-like beta-sandwich: *Fold b.1 ... Fold b.1: Immunoglobulin-like beta-sandwich appears in SCOPe 2.03. *Fold b.1: Immunoglobulin-like beta-sandwich appears in the ... Immunoglobulin-like beta-sandwich first appeared (with stable ids) in SCOP 1.55. *Fold b.1: Immunoglobulin-like beta-sandwich ... Fold b.1: Immunoglobulin-like beta-sandwich [48725] (28 superfamilies). sandwich; 7 strands in 2 sheets; greek-key. some ...

http://scop.berkeley.edu/sunid=48725&ver=2.02

The receptors studied include the polymeric immunoglobulin receptor (pIgR), the neonatal receptor (FcRn), the Fcα/μR, the ... Although albuminuria is most widely studied, higher molecular weight proteins such as immunoglobulins (Ig) are more associated ...

https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.495310

IgA-deficient patients with immunoglobulin E (IgE)-class anti-IgA antibodies are at risk for anaphylaxis if they receive blood or intravenous immunoglobulin, but this situation is extremely rare. (medscape.com)
An IgA test measures the blood level of immunoglobulin A, one of the most common types of antibodies in the body. (kidshealth.org)
Antibodies (also called immunoglobulins) are proteins the immune system makes to recognize and get rid of germs . (kidshealth.org)
Immunoglobulins are characterized as antibodies that are produced naturally by the body's immune system.They primarily help fight diseases and infections. (reportlinker.com)
In the absence of normal IgA, the body can develop an immune response against IgA itself (anti-IgA antibodies), which can lead to severe reactions including anaphylaxis to blood transfusions or intravenous immunoglobulin . (bionity.com)
Pooled antibodies are made from immunoglobulins processed from donated blood from thousands of individuals, containing all of the various types of antibodies that neutralize the unwanted effects of ACPAs. (antaresoptical.com)
Concentrated human immunoglobulin (IVIG) has been administered intravenously in the treatment of autoimmune disorders and to reduce anti-HLA antibodies in highly sensitized patients awaiting organ transplantation. (elsevier.com)
In this study, the presence of immunoglobulins on the surface of lesion-derived amastigotes was detected by Western blotting using three different peroxidase conjugated anti-heavy chain antibodies and peroxidase conjugated anti-mouse IgG antibody. (ac.ir)
Methods Immunohistochemical staining with conformation-specific and sequence-specific antibodies was used to localize different amyloid species of light chain immunoglobulins in a case of PCNA. (utmb.edu)
Hyperimmune immunoglobulin to SARS-CoV-2 (hIVIG) is obtained from the plasma of patients who recover from COVID-19 and develop neutralizing antibodies. (drugbank.com)
1 Anti-coronavirus immunoglobulin is derived from COVID-19 convalescent plasma (https://go.drugbank.com/drugs/DB15692) but contains more SARS-CoV-2 neutralizing antibodies than found in convalescent plasma as the antibodies are highly purified and concentrated. (drugbank.com)
They carry enzymes, antibodies (immunoglobulins) and other proteins. (aidsmap.com)
Assays discussed include functional cell-based assays for immunoglobulin and TNFR superfamilies like CD28, ICOS, PD1, CD47, SIRPα, and OX40 and assays for testing agonist antibodies (clustering and binding assays for bi-specifics). (discoverx.com)
An immunoglobulins test measures the levels of certain antibodies in your. (modegame.online)
COVID-19 Coronavirus Antibody Serology Test This bucket a blood test It is designed to detect antibodies immunoglobulins IgG and IgM against the coronavirus. (modegame.online)
Immunoglobulins are antibodies that prevent infections. (mummaandhermonsters.com)
The immunoglobulin elicits neutralizing antibodies and has a half-life of 21 days. (medscape.com)
Your immune system overreacts by producing antibodies called Immunoglobulin E (IgE). (asthmanc.com)
Immunoglobulins are also called antibodies. (medlineplus.gov)
Secondary antibodies produced cover a broad range of immunoglobulins from various species cross absorbed to provide high specificity. (immunoreagents.com)
To determine if RRV has circulated locally among the French Polynesian population, we conducted a seroprevalence study on blood donors.Methods: Sera of 593 blood donors were collected from July 2011 to October 2013 and tested by ELISA for the presence of RRV-specific Immunoglobulin G (IgG) antibodies.Results: A total of 204 (34.40%) blood donors were found seropositive for RRV. (univ-reunion.fr)
SARS-CoV-2 IgG seroconversion or a four-fold or greater increase in SARS-CoV-2 antibodies of any immunoglobulin subclass including 'total' assays in acute and convalescent sera, in the absence of vaccination. (vic.gov.au)

Performing an early assessment of risk factors, infusing at a slow rate, premedicating, and switching from intravenous immunoglobulin (IVIG) to subcutaneous immunoglobulin (SCIG) can minimize these adverse effects. (frontiersin.org)
Hence, many scholars began to explore intravenous immunoglobulin (IVIG) preparations. (frontiersin.org)
The TGA has become aware of reports of a markedly increased incidence of serious adverse reactions associated with Octagam, an intravenous immunoglobulin (IVIg) preparation, manufactured by Octapharma in Europe. (tga.gov.au)
This clinical study will evaluate the effectiveness of intravenous immunoglobulin (IVIG) in improving the live birth rate in couples who suffer from secondary recurrent miscarriage. (clinicaltrials.gov)
Increasing awareness of IRT options for patients with PIDs, which is given as intravenous immunoglobulin (IVIg) or subcutaneous immunoglobulin (SCIg), and the pros and cons of IVIg versus SCIg. (allergy.org.au)
This survey is aimed specifically at adults with PI who currently receive either Subcutaneous (SCIG) or Intravenous (IVIG) immunoglobulin replacement. (primaryimmune.org)
Intravenous immunoglobulin (IVIG) use in non-approved indications, the increase in consumption and its high cost recommend rationalisation in its utilisation. (cun.es)
Placebo-controlled treatment trials with high dose intravenous immunoglobulins (IVIG) have shown disease amelioration in some but not all patients. (uzh.ch)
1 Based on its clinical and immunological similarities with heparin-induced thrombocytopenia (HIT), early treatment with high-dose intravenous immunoglobulin (IVIg) along with anticoagulation was recommended by the Expert Haematology Panel in March 2021 2 and supported by the National Institute for Health Care Excellence. (bmj.com)
What is intravenous immunoglobulin (IVIg)? (thewaltoncentre.nhs.uk)
Intravenous Immunoglobulin (IVIg) Market Estimated to Record. (debwan.com)
Noteworthy growth in the incidences of neurological disorders and autoimmune diseases across the globe is projected to help in the expansion of the global intravenous immunoglobulin (IVIG) market , according to a new study published by TMR. (debwan.com)
This factor is likely to work as one of the key driver for the growth of the intravenous immunoglobulin (IVIG) market. (debwan.com)
The players operating in the intravenous immunoglobulin (IVIG) market are projected to gather prodigious avenues from the home care end-user segment. (debwan.com)
This growth of the market for of intravenous immunoglobulin (IVIG) is attributable to many factors including shifting patients' preference for improved care at home, largely in many developed countries. (debwan.com)
This scenario is creating prominent demand opportunities for home care end-user segment of the intravenous immunoglobulin (IVIG) market. (debwan.com)
Major enterprises in the intravenous immunoglobulin (IVIG) market are increasing their investments in the research and development activities. (debwan.com)
Europe, North America, Latin America, Middle East & Africa, and Asia Pacific are some of the important regions for the global intravenous immunoglobulin (IVIG) market. (debwan.com)
The Asia Pacific intravenous immunoglobulin (IVIG) market is likely to experience sizable expansion opportunities in the forthcoming years. (debwan.com)
The segmentation of the global intravenous immunoglobulin (IVIG) market is performed on the basis of various key aspects such as end-user, indication, and region. (debwan.com)
Based on end-user, the market for intravenous immunoglobulin (IVIG) is classified into hospital, homecare, and clinic. (debwan.com)
In terms of indication, the intravenous immunoglobulin (IVIG) market is divided into idiopathic thrombocytopenic purpura (ITP), chronic inflammatory demyelinating polyneuropathy (CIDP), primary humoral immunodeficiency, myasthenia gravis, guillain-barre syndrome, Kawasaki disease, multifocal motor neuropathy (MMN), chronic lymphocytic leukemia, and hypogammaglobulinemia. (debwan.com)
KD can be treated with high dosage of intravenous immunoglobulin (IVIG), that leads to the fast cessation of fever and swelling in nearly all individuals treated within 10 times of fever starting point. (forgetmenotinitiative.org)
A large randomized crossover trial was conducted in patients with a high risk of sepsis by comparing oral prednisone at a dose of 200-500 mg/day with intravenous immunoglobulin (IVIG) (Larsson et al, supplement cutting stack. (respectclothing.online)

Immunoglobulin G (Ig G) is a type of antibody. (wikipedia.org)
Selective immunoglobulin A deficiency (SIgAD) is a primary immunodeficiency disease and is the most common of the primary antibody deficiencies. (medscape.com)
IgG stands for immunoglobulin G. It is a type of antibody. (medlineplus.gov)
Immunoglobulins, which are protein molecules that contain antibody activity, are produced by the terminal cells of B-cell differentiation known as plasma cells. (medscape.com)
People with this deficiency lack immunoglobulin A (IgA), a type of antibody that protects against infections of the mucous membranes lining the mouth, airways, and digestive tract. (bionity.com)
These people have high levels of an allergy-causing antibody (a type of immune protein in the body) called immunoglobulin E (IgE). (teenshealth.org)
An immunoglobulin E (IgE) test measures the level of IgE, a type of antibody. (connecticutchildrens.org)
Suspected PIDDs should be evaluated in a stepwise fashion, with initial, nonspecific testing that includes measurement of total serum immunoglobulin and evaluation of antibody titers. (arupconsult.com)
A. Gardulf, (2007) Immunoglobulin treatment for primary antibody deficiencies: Advantages of the subcutaneous route. (scirp.org)
B. Hogy, H. O. Keinecke, M. Borte, (2005) Pharma-coeconomic evaluation of immunoglobulin treatment in patients with antibody deficiencies from the perspective of the German statutory health insurance. (scirp.org)
Phase I study of every 2- or 3-week dosing of ramucirumab, a human immunoglobulin G1 monoclonal antibody targeting the vascular endothelial growth factor receptor-2 in patients with advanced solid tumors. (duke.edu)
BACKGROUND: Ramucirumab is a fully human immunoglobulin G1 monoclonal antibody receptor antagonist designed to block the ligand-binding site of vascular endothelial growth factor receptor-2 (VEGFR-2). (duke.edu)
An antibody, also called immunoglobulin, is a protective protein produced by the immune system in response to the presence of a foreign substance, called an antigen. (proteomicsresource.org)
4. Surface Immunoglobulin Ligands and Cytokines Differentially Affect Proliferation and Antibody Production by Human CD5+ and CD5- B Lymphocytes. (nordicmubio.com)
It's used for the one-step purification of monoclonal antibody products (mAb) and immunoglobulins from a cell culture media. (excedr.com)
The Protein A affinity chromatography technique is extensively used in labs to capture and purify immunoglobulins, such as IgG and monoclonal antibody products. (excedr.com)

Although albuminuria is most widely studied, higher molecular weight proteins such as immunoglobulins (Ig) are more associated with progression of renal disease. (bl.uk)
Immunoglobulin therapies are unique biologics and replace missing or functionally impaired proteins in individuals born with a range of genetic and often life-threatening diseases. (pptaglobal.org)
Immunoglobulins are proteins produced by the immune system ( the body's defence system). (thewaltoncentre.nhs.uk)
Mutations at A/T bases within immunoglobulin genes have been shown to be generated by a repair pathway involving the DNA-binding moiety of the mismatch repair complex constituted by the MSH2-MSH6 proteins, together with DNA polymerase η (pol η). (rupress.org)
One of the important properties of lesion-derived amastigote is thought to be the attachment of various host proteins including immunoglobulins on the surface of amastigote. (ac.ir)
Immunoglobulin response to Plasmodium falciparum RESA proteins in uncomplicated and severe malaria. (archives-ouvertes.fr)
This finding suggests that immunoglobulin amyloids can act as seeds capable of inducing the aggregation of heterogeneous proteins in the skin. (utmb.edu)
Other than Protein A, the bacteria also have other immunoglobulin-binding bacterial proteins, such as Protein A/G, Protein L, and Protein G. (excedr.com)

Adaptive immune responses require rearrangement of the genes responsible for the specific recognition structures, ie, immunoglobulins for humoral immunity and T-cell receptors for cellular immunity. (medscape.com)
Structure and expression of the human immunoglobulin lambda genes. (nih.gov)
The study of such processes has been compromised by difficulties in reliably aligning immunoglobulin genes and in the partitioning of nucleotides between segment ends, and between N and P nucleotides. (garvan.org.au)
wounds for doing us about the epub immunoglobulin genes. (enetincorporated.com)
In epub immunoglobulin genes, after the Civil War, the physical button of J. Horace Lacy, the software of both the Chatham and Ellwood characters, contributed download first, because of the knowledge of his states and length of his materials. (enetincorporated.com)
Up-regulated genes included immunoglobulin-related transcripts. (virginia.edu)

2008) Subcutaneous versus intravenous immunoglobulin for primary immu-nodeficiencies: Systematic review and economic evalua-tion. (scirp.org)
Patients self-administering subcutaneous immunoglobulin (SCIg) are advised to record their treatment details. (nba.gov.au)

IgG deficiencies may occur as isolated deficiencies (eg, selective IgG deficiency) or in association with deficiencies of other immunoglobulin types. (medscape.com)
For information on deficiencies of other immunoglobulin types, see the Medscape Reference articles IgA Deficiency , IgD Deficiency , and IgM Deficiency . (medscape.com)
Selective immunoglobulin A (IgA) deficiency is a relatively mild genetic immunodeficiency . (bionity.com)
It uses material from the Wikipedia article "Selective_immunoglobulin_A_deficiency" . (bionity.com)
AusPIPS is an organisation that advocates and supports people who have Primary Immune Deficiency and it has developed an immunoglobulin brochure for patients. (nba.gov.au)
Hong R, Gupta S. Selective immunoglobulin M deficiency in an adult with Streptococcus pneumoniae sepsis and invasive aspergillosis. (medscape.com)
Belgemen T, Suskan E, Dogu F, Ikinciogullari A. Selective Immunoglobulin M Deficiency Presenting with Recurrent Impetigo: A Case Report and Review of the Literature. (medscape.com)
Antar M, Lamarche J, Peguero A, Reiss A, Cole S. A case of selective immunoglobulin M deficiency and autoimmune glomerulonephritis. (medscape.com)
Chronic recurrent multifocal osteomyelitis in a patient with selective immunoglobulin M deficiency. (medscape.com)

Recognition of immunoglobulins by Fcgamma receptors. (nih.gov)
The receptors studied include the polymeric immunoglobulin receptor (pIgR), the neonatal receptor (FcRn), the Fcα/μR, the classical IgG receptors (FcγR1, γIIa, γIIb, γIII and the related FcR γ-chain) and the classical IgA receptor (FcαR). (bl.uk)
In humans, CD94/NKG2A receptor and the variable killer immunoglobulin-like receptors (KIRs) recognizing HLA I molecules on target cells are common inhibitory receptors. (miltenyibiotec.com)

CD3, also known as T3, is a member of the immunoglobulin superfamily that plays a role in antigen recognition, signal transduction, and T cell activation. (biolegend.com)
The MRC OX-45 antigen of rat leukocytes and endothelium is in a subset of the immunoglobulin superfamily with CD2, LFA-3 and carcinoembryonic antigens. (hcdm.org)
2B4, the natural killer and T cell immunoglobulin superfamily surface protein, is a ligand for CD48. (hcdm.org)
The human CD19 antigen is a 95 kd transmembrane glycoprotein belonging to the immunoglobulin superfamily. (probomedlabs.com)

The DNA-binding protein CTCF limits proximal Vκ recombination and restricts κ enhancer interactions to the immunoglobulin κ light chain locus. (cnrs.fr)
Provides beneficial whey protein microfractions including immunoglobulin and lactoferrin. (evergreennutrition.com)

Individuals with such an unusual profile should receive only low IgA intravenous immunoglobulin preparations. (medscape.com)
Although thromboembolic events are a known rare adverse event associated with the administration of all intravenous immunoglobulin preparations, as described in the prescribing information for these products, there has recently been a steady accumulation of such events reported following administration of Octagam in Europe and the USA, with a marked increase in incidence noted during the last few months of 2010. (tga.gov.au)

Patients who receive immunoglobulin therapy are often treated with immunoglobulin in repeated infusions over a long period of time, and the incidence of adverse effects related to immunoglobulin varies across a wide range. (frontiersin.org)
Doctors should cease using Octagam intravenous immunoglobulin solutions immediately, and switch their patients to the most appropriate alternative treatment. (tga.gov.au)
Patients and health care providers should report any adverse events that have occurred following administration of Octagam intravenous immunoglobulin solution to the TGA via the Adverse Medicine Events Line (1300 134 237), online via ' Report a problem with a medicine ', or using the 'Blue Card' Prepaid Reporting Form . (tga.gov.au)
Data on the number of patients, immunoglobulin market shares and drug unit costs were derived from the IMS Health hospital disease database and from Belgian sources. (scirp.org)
Assisting GPs, paediatricians and other medical specialists to recognise the early signs of PID and refer patients to a clinical immunologist to confirm diagnosis and initiate treatment, including immunoglobulin replacement therapy (IRT) if required. (allergy.org.au)
Intravenous Immunoglobulin Therapy in Patients With Painful Idiopathic Small Fiber Neuropathy," by Geerts et al. (neurology.org)
No defined blood test or tumour markers are currently available to diagnose this entity except serum immunoglobulin G4 which is costly and not feasible to get done in all patients especially in developing nations like India. (researchsquare.com)
A number of resources are available to help health professionals and patients understand and manage immunoglobulin (Ig) treatment arrangements. (nba.gov.au)
The following resources are designed to support patients and their carers through every stage of their immunoglobulin treatment journey. (nba.gov.au)
The brochure explains the use of immunoglobulin replacement therapy and provides tips for new and existing patients receiving treatment. (nba.gov.au)
Immunoglobulin product is available in Australia at no direct cost to eligible patients under the national blood arrangements, managed by the NBA. (nba.gov.au)
Serum immunoglobulins were were estimated in schizophrenic patients and were age and sex matched with 40 healthy individuals, comprising the control group. (who.int)
Recently, a highly specific serum reactivity to CNS microvessels, subpia and Virchow-Robin spaces was described in patients with NMO [called NMO-IgG (NMO-immunoglobulin G)]. Subsequently, aquaporin-4 (AQP4), the most abundant water channel in the CNS, was identified as its target antigen. (ox.ac.uk)
Kamada is developing anti coronavirus polyclonal immunoglobulin treatment for severely ill COVID- 19 patients. (who.int)

The results showed that the surface of amastigote has covered with different amount of immunoglobulins such as IgG, IgM, and IgA detected by pixel analysis software. (ac.ir)
This test measures the amount of immunoglobulins in your blood. (medlineplus.gov)

The global immunoglobulin market is anticipated to rise with a CAGR of 6.87% across the forecast years of 2022 to 2030. (reportlinker.com)

Immunoglobulins have important roles in humoral immunity, and they consist of 5 major classes or isotypes: immunoglobulin G (IgG), immunoglobulin A (IgA), immunoglobulin M (IgM), immunoglobulin D (IgD), and immunoglobulin E (IgE). (medscape.com)
You can now search immunoglobulin (Ig) nucleotide sequences against the Constant region (C) gene database (Figure 1) to determine the Ig isotypes including subtypes (IgM, IgG, IgA1, etc. (nih.gov)

Previous characterization of mouse immunoglobulin κ gene rearrangement products cloned from murine plasmacytomas has indicated that two recombination events can take place on a single κ allele (R. M. Feddersen and B. G. Van Ness, Proc. (umn.edu)
Feddersen, RM & Van Ness, BG 1990, ' Corrective recombination of mouse immunoglobulin kappa alleles in Abelson murine leukemia virus-transformed pre-B cells ', Molecular and cellular biology , vol. 10, no. 2, pp. 569-576. (umn.edu)

After eliminating conditions that may increase susceptibility to infection (eg, adenoid hypertrophy, cystic fibrosis , immunosuppression), an initial workup may include CBC, quantitative serum immunoglobulins, IgG vaccine titers, and complement testing. (arupconsult.com)
B cells and serum immunoglobulins were not detected in BCR KO animals. (cdc.gov)
Serum immunoglobulins were within normal limits. (glomcon.org)

These adverse effects are associated with specific immunoglobulin preparations and individual differences. (frontiersin.org)
Background: Severe asthma in horses, known as severe equine asthma (SEA), is a prevalent, performance‐limiting disease associated with increased allergen‐specific immunoglobulin E (IgE) against a range of environmental aeroallergens. (ntu.ac.uk)

In 1952, Bruton ( 12 ) was the first to use immunoglobulin to treat a patient identified as immunodeficient, and it later became a standard therapy for immunodeficiency diseases. (frontiersin.org)
Share Your Experiences with Immunoglobulin Replacement Therapy. (primaryimmune.org)
Immediate therapy, provided prior to the administration of vaccine and immunoglobulin, consists of the thorough cleaning of all bite and scratch wounds with soap and water, 2% benzalkonium chloride, and/or a virucidal agent (ie, povidone-iodine solution). (medscape.com)
For example, one 2014 study reviewing paternal cell immunization, third‐party donor leukocytes, trophoblast membranes, and intravenous immunoglobulin failed to find evidence of a significant effect of any therapy over placebo. (azolifesciences.com)

Intramuscular immunoglobulin preparations were not widely applied because of their poor tolerance. (frontiersin.org)
Biomeda's immunoglobulin (IgG) preparations are used for affinity columns, blocking agents, and normal controls in a variety of immuno assays. (biomeda.com)

The present study set out to investigate the dynamic changes in salivary secretory immunoglobulin A (sIgA) and cortisol before and after acute stress, and to analyse the relationship between sIgA and cortisol trend. (elsevier.com)
We have found that the development of inflammation in severe inflammatory periodontal diseases, in particular, chronic generalized periodontitis requiring tooth extraction for oral cavity sanitation is characterized by functional insufficiency of secretory immunity of the oral mucosa associated with decreased secretion of secretory immunoglobulin A and antimicrobial peptides of neutrophilic origin, as well as a shift in the salivary cytokine balance towards increased production of pro-inflammatory cytokines. (rusimmun.ru)
Higher levels of salivary immunoglobulin A decrease the adherence of bacteria associated with dental plaques and prevent tooth decay. (myassignmenthelp.com)

There is an inherited inability to produce immunoglobulin A (IgA), a part of the body's defenses against infection at the body's surfaces (mainly the surfaces of the respiratory and digestive systems). (bionity.com)
Immunoglobulins in saliva add to the body's defence armour. (myassignmenthelp.com)
In addition, immunoglobulins strengthen body's immune system and glycomacropeptides control the appetite. (weider.ie)

Secretory IgA (SIgA) represents the most abundant immunoglobulin of body secretions such as saliva, tears, colostrum and gastrointestinal secretions. (invivogen.com)

Oligomers were mainly formed by lambda light chain immunoglobulins, and kappa light chain oligomers were detected in lesser amounts. (utmb.edu)

This document is a source for ASCIA IRT e-training for health professionals which is available at https://immunodeficiency.ascia.org.au This e-training course was developed as part of the National Prescribing Service (NPS) MedicineWise ViP Immunoglobulin project. (allergy.org.au)

Acute lung injury in rat caused by immunoglobulin A immune complexes. (jci.org)

Fortunately, rabies can be prevented by administering vaccine and immunoglobulin after an exposure occurs. (cdc.gov)
Contacts who were not immune were given the MMR vaccine or, if not vaccine-eligible, immunoglobulin. (cdc.gov)

Immunoglobulin has been widely used in a variety of diseases, including primary and secondary immunodeficiency diseases, neuromuscular diseases, and Kawasaki disease. (frontiersin.org)
Applications involving immunoglobulin have expanded to include treatment for immunodeficiency diseases, idiopathic thrombocytopenic purpura (ITP), Kawasaki disease, and neurologic disorders (including Guillain-Barre syndrome, chronic inflammatory demyelinating polyneuropathy, myasthenia gravis, multiple myositis, multiple sclerosis, and autoimmune encephalitis) ( 2 - 8 ). (frontiersin.org)
Hence, the growth in the elderly is set to augment the prevalence of age-related diseases, subsequently increasing the need for immunoglobulin products for their treatment. (reportlinker.com)
They include biomarker-immunoglobulin M (IgM) complexes, which have been found in several neoplastic diseases, such as colorectal, liver, and prostate cancer [ 1 - 3 ]. (hindawi.com)
In light chain (LC) diseases, monoclonal immunoglobulin LCs are abundantly produced with the consequence in some cases to form deposits of a fibrillar or amorphous nature affecting various organs, such as heart and kidney. (peerj.com)
Colostrum Capsules Vestige Colostrum is a rich natural source of Immunoglobulins that helps in strengthening the immune system and increases protection against various diseases. (vestjoin.com)

Human immunoglobulin G subclasses. (medscape.com)
11 ) successfully developed a process for the large-scale production of human immunoglobulin. (frontiersin.org)
2007. Non-Human Transgenic Mammal for the Constant Region of the Class a Human Immunoglobulin Heavy Chain and Applications Thereof. (invivogen.com)
Methods: NMO lesions were produced in mice by intracerebral injection of immunoglobulin G (IgG) isolated from NMO patient serum and human complement. (ox.ac.uk)
Additionally, in vitro characterization of immunoglobulin oligomers and fibrils was performed to determine, through toxicity studies in a human keratinocyte cell line, which amyloidogenic form of the immunoglobulin is toxic in PCNA. (utmb.edu)
Furthermore, cytotoxicity studies demonstrated that immunoglobulin oligomers, but not monomers or fibrils, are toxic to human keratinocytes. (utmb.edu)
Description - Tenders are invited for the supply of a drug for medical use of human immunoglobulin against tick -borne encephalitis Global Tenders is not only confined to tenders but we also upload crucial information, from future prospects to past market records. (globaltenders.com)
Description: A sandwich quantitative ELISA assay kit for detection of Human Immunoglobulin M (IgM) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. (todayfinancialnews.com)
Passive immunization with human rabies immunoglobulin (HRIG, HyperRab S/D, KedRab, Imogam Rabies-HT) provides immediate protection. (medscape.com)

In September 2008, CDC, the Food and Drug Administration (FDA), and state health departments began a nationwide investigation into an increase in false-positive test results obtained with a commercially available West Nile virus (WNV) immunoglobulin M (IgM) capture enzyme-linked immunosorbent assay (ELISA). (cdc.gov)

The rise in the geriatric population across the world is a leading factor expected to fuel the global immunoglobulin market growth over the forecasted years.As an individual ages, their immune system tends to deteriorate and responds relatively slower. (reportlinker.com)
Immunoglobulin A (IgA), in its secretory form, is the main effector of the mucosal immune system and provides an important first line of defense against most pathogens that invade the body at a mucosal surface [1] . (invivogen.com)

Predicted to enable antigen binding activity and immunoglobulin receptor binding activity. (nih.gov)
This study was aimed at defining molecular species of prostate-specific antigen (PSA) in immune complexes with immunoglobulin M (IgM). (hindawi.com)

B-cell immunity is mediated by the immunoglobulins and is commonly referred to as humoral immunity. (medscape.com)

Secretory IgA, a major immunoglobulin in most bovine external secretions. (unil.ch)

The aim of this study is to compute the budget impact of adopting Kiovig, a new ready-to-use 10% liquid immunoglobulin preparation, as a treatment for primary immunodeficiency from the perspective of the Belgian health care payer. (scirp.org)
The analysis compared the "world with Kiovig" to the "world without Kiovig" and calculated how a change in the mix of immunoglobulins used to treat primary immunodeficiency would impact drug spending during 2010-2014. (scirp.org)

The aim of this treatment is to replace immunoglobulin to maintain normal Immunoglobulin G (IgG) levels, with the dose used individualised for each patient. (allergy.org.au)
Treatment of inclusion body myositis: is low-dose intravenous immunoglobulin the solution? (uzh.ch)
I, like many other with ME, were given immunoglobulin injections as an experimental treatment for our disease. (phoenixrising.me)
Immunoglobulin oligomers may prove to be targets for the treatment of PCNA. (utmb.edu)

A high A/G ratio suggests underproduction of immunoglobulins (as may be seen in some genetic deficiencies and in some leukemias). (baysport.com)

Process that minimizes or prevents immunoglobulin-associated adverse reactions. (frontiersin.org)

2002. Multiple functions of immunoglobulin A in mucosal defense against viruses: an in vitro measles virus model. (invivogen.com)

The most abundant class of immunoglobulins in the blood is IgG (73%), which has a molecular weight of 150 kd. (medscape.com)

The best line of defense against invading pathogens in the newborn dairy calf is the immunoglobulins from colostrum that are absorbed in the small intestine. (scielo.sa.cr)

BACKGROUND: Immunoglobulin rearrangement involves random and imprecise processes that act to both create and constrain diversity. (garvan.org.au)

Although a large number of clinical trials have demonstrated that immunoglobulin is effective and well tolerated, various adverse effects have been reported. (frontiersin.org)
In this paper, we reviewed the incidence, risk factors, clinical manifestations of and preventive measures for adverse effects related to immunoglobulin. (frontiersin.org)
Adequate supplies of alternative intravenous immunoglobulin solution products are available for clinical use in Australia, and it is not anticipated that this recall will lead to any shortage of supply in the foreseeable future. (tga.gov.au)

This repertoire of immunoglobulins is crucial for the newborns who are very sensitive to infections, especially within the respiratory and digestive systems. (wikipedia.org)
It is the most common type of immunoglobulin in newborns and, and her partner did not use condoms. (modegame.online)
to review and describe the management of primary maternal CMV infections using CMV hyper immunoglobulin (CMVIG) and the outcome of the newborns and update the international experience. (scholarena.co)

The first is excessive TSH receptor stimulation, and an example is Graves' disease, which is an autoimmune condition where thyroid stimulating immunoglobulins, or TSIs, bind to the TSH receptor and stimulate excess hormone production. (osmosis.org)

MF provided and validated data on immunoglobulin use in VITT. (bmj.com)

Recent media reports have described access issues regarding immunoglobulin (Ig) therapies relied on by people living with primary immunodeficiencies. (pptaglobal.org)
Finally, by the same rule, B cells must first release M then G immunoglobulin on primary exposure. (neetexambooster.in)
CMV hyper immunoglobulin (CMVIG) was used as prophylaxis in pregnant women diagnosed with primary CMV in early pregnancy, before amniocentesis. (scholarena.co)

The amyloid deposits are found in the dermis and subcutis, and they contain clonal immunoglobulin light chains, produced by a local proliferation of plasma cells. (utmb.edu)

2007. The function of immunoglobulin A in immunity. (invivogen.com)

Eastern Equine Encephalitis Treated With Intravenous Immunoglobulins. (escholarship.org)

The role of complement in immunoglobulin G-triggered inflammation was studied in mice genetically deficient in complement components C3 and C4. (nih.gov)
2021. Transferable Immunoglobulin A-Coated Odoribacter splanchnicus in Responders to Fecal Microbiota Transplantation for Ulcerative Colitis Limits Colonic Inflammation. . (weillcornell.org)

Anatomy23

Organisms20

Diseases43

Chemicals and Drugs102

Analytical, Diagnostic and Therapeutic Techniques and Equipment33

Phenomena and Processes42

Technology, Industry, Agriculture2

Information Science3

Named Groups2

Health Care5

Interleukin-8 receptor modulates IgE production and B-cell expansion and trafficking in allergen-induced pulmonary inflammation. (1/5385)

gp49B1 inhibits IgE-initiated mast cell activation through both immunoreceptor tyrosine-based inhibitory motifs, recruitment of src homology 2 domain-containing phosphatase-1, and suppression of early and late calcium mobilization. (2/5385)

Hyper-IgE syndrome with recurrent infections--an autosomal dominant multisystem disorder. (3/5385)

Exhaled and nasal NO levels in allergic rhinitis: relation to sensitization, pollen season and bronchial hyperresponsiveness. (4/5385)

Immunosurveillance of alglucerase enzyme therapy for Gaucher patients: induction of humoral tolerance in seroconverted patients after repeat administration. (5/5385)

Involvement of tachykinin receptors in sensitisation to cow's milk proteins in guinea pigs. (6/5385)

Induction of Ig somatic hypermutation and class switching in a human monoclonal IgM+ IgD+ B cell line in vitro: definition of the requirements and modalities of hypermutation. (7/5385)

Evidence for the involvement of IgE-basophil system in acute serum sickness. (8/5385)

Immunoglobulin E

Immunoglobulin G

Immunoglobulins

Immunoglobulin M

Immunoglobulin A

Receptors, IgE

Immunoglobulin Heavy Chains

Allergens

Immunoglobulins, Intravenous

Genes, Immunoglobulin

Hypersensitivity

Immunoglobulin Light Chains

Hypersensitivity, Immediate

Basophils

Skin Tests

Immunoglobulin kappa-Chains

Food Hypersensitivity

Immunoglobulin Isotypes

Mast Cells

Immunoglobulin A, Secretory

Immunoglobulin Variable Region

B-Lymphocytes

Immunoglobulin Fc Fragments

Immunoglobulin mu-Chains

Radioallergosorbent Test

Immunoglobulin Class Switching

Immunoglobulin lambda-Chains

Asthma

Antibodies, Anti-Idiotypic

Immunoglobulin D

Histamine Release

Interleukin-4

Immunoglobulin Constant Regions

Immunoglobulin epsilon-Chains

Dermatitis, Atopic

Enzyme-Linked Immunosorbent Assay

Receptors, Fc

Antigens, Plant

Anaphylaxis

Latex Hypersensitivity

Antibody Specificity

Immunoglobulin gamma-Chains

Leukemia, Basophilic, Acute

Mice, Inbred BALB C

Immunoglobulin Fab Fragments

Acaridae

Rhinitis, Allergic, Perennial

Immunoglobulin J-Chains

Immunoglobulin Fragments

Rhinitis, Allergic, Seasonal

Immunoglobulin Allotypes

Passive Cutaneous Anaphylaxis

Receptors, Polymeric Immunoglobulin

Ovalbumin

Milk Hypersensitivity

Molecular Sequence Data

Immunoglobulin Joining Region

Antibodies, Bacterial

Antigens, Differentiation, B-Lymphocyte

Bronchial Hyperreactivity

Respiratory Hypersensitivity

Hypergammaglobulinemia

Antibody Formation

Th2 Cells

Mites

Antibodies, Helminth

Antigens, Dermatophagoides

Egg Hypersensitivity

Antibodies, Monoclonal

Peanut Hypersensitivity

Base Sequence

Cell Degranulation

Pollen

Anti-Allergic Agents

Intradermal Tests

Amino Acid Sequence

Receptors, Antigen, B-Cell

Cross Reactions

Antibodies, Fungal

Myeloma Proteins