Immunocompromised Host
Immunocompetence
Opportunistic Infections
Pneumocystis carinii
Antifungal Agents
Aspergillus fumigatus
Trichosporon
Strongyloidiasis
Central Nervous System Infections
Pathogenic infections of the brain, spinal cord, and meninges. DNA VIRUS INFECTIONS; RNA VIRUS INFECTIONS; BACTERIAL INFECTIONS; MYCOPLASMA INFECTIONS; SPIROCHAETALES INFECTIONS; fungal infections; PROTOZOAN INFECTIONS; HELMINTHIASIS; and PRION DISEASES may involve the central nervous system as a primary or secondary process.
Mucormycosis
Infection in humans and animals caused by any fungus in the order Mucorales (e.g., Absidia, Mucor, Rhizopus etc.) There are many clinical types associated with infection of the central nervous system, lung, gastrointestinal tract, skin, orbit and paranasal sinuses. In humans, it usually occurs as an opportunistic infection in patients with a chronic debilitating disease, particularly uncontrolled diabetes, or who are receiving immunosuppressive agents. (From Dorland, 28th ed)
Strongyloides stercoralis
Fatal Outcome
Cytomegalovirus Infections
Transplantation
Cytomegalovirus
A genus of the family HERPESVIRIDAE, subfamily BETAHERPESVIRINAE, infecting the salivary glands, liver, spleen, lungs, eyes, and other organs, in which they produce characteristically enlarged cells with intranuclear inclusions. Infection with Cytomegalovirus is also seen as an opportunistic infection in AIDS.
Candidiasis
Parasitic Diseases
Lung Diseases, Fungal
Bacteremia
The presence of viable bacteria circulating in the blood. Fever, chills, tachycardia, and tachypnea are common acute manifestations of bacteremia. The majority of cases are seen in already hospitalized patients, most of whom have underlying diseases or procedures which render their bloodstreams susceptible to invasion.
Aspergillus
Cryptococcus neoformans
Immunologic Deficiency Syndromes
Amphotericin B
Cryptosporidiosis
Organ Transplantation
AIDS-Related Opportunistic Infections
Opportunistic infections found in patients who test positive for human immunodeficiency virus (HIV). The most common include PNEUMOCYSTIS PNEUMONIA, Kaposi's sarcoma, cryptosporidiosis, herpes simplex, toxoplasmosis, cryptococcosis, and infections with Mycobacterium avium complex, Microsporidium, and Cytomegalovirus.
Pneumonia, Pneumocystis
A pulmonary disease in humans occurring in immunodeficient or malnourished patients or infants, characterized by DYSPNEA, tachypnea, and HYPOXEMIA. Pneumocystis pneumonia is a frequently seen opportunistic infection in AIDS. It is caused by the fungus PNEUMOCYSTIS JIROVECII. The disease is also found in other MAMMALS where it is caused by related species of Pneumocystis.
Candida
A genus of yeast-like mitosporic Saccharomycetales fungi characterized by producing yeast cells, mycelia, pseudomycelia, and blastophores. It is commonly part of the normal flora of the skin, mouth, intestinal tract, and vagina, but can cause a variety of infections, including CANDIDIASIS; ONYCHOMYCOSIS; vulvovaginal candidiasis (CANDIDIASIS, VULVOVAGINAL), and thrush (see CANDIDIASIS, ORAL). (From Dorland, 28th ed)
Immunosuppression
Deliberate prevention or diminution of the host's immune response. It may be nonspecific as in the administration of immunosuppressive agents (drugs or radiation) or by lymphocyte depletion or may be specific as in desensitization or the simultaneous administration of antigen and immunosuppressive drugs.
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Fungi
A kingdom of eukaryotic, heterotrophic organisms that live parasitically as saprobes, including MUSHROOMS; YEASTS; smuts, molds, etc. They reproduce either sexually or asexually, and have life cycles that range from simple to complex. Filamentous fungi, commonly known as molds, refer to those that grow as multicellular colonies.
Polymerase Chain Reaction
In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.
Virulence
Antiviral Agents
Agents used in the prophylaxis or therapy of VIRUS DISEASES. Some of the ways they may act include preventing viral replication by inhibiting viral DNA polymerase; binding to specific cell-surface receptors and inhibiting viral penetration or uncoating; inhibiting viral protein synthesis; or blocking late stages of virus assembly.
Acquired Immunodeficiency Syndrome
An acquired defect of cellular immunity associated with infection by the human immunodeficiency virus (HIV), a CD4-positive T-lymphocyte count under 200 cells/microliter or less than 14% of total lymphocytes, and increased susceptibility to opportunistic infections and malignant neoplasms. Clinical manifestations also include emaciation (wasting) and dementia. These elements reflect criteria for AIDS as defined by the CDC in 1993.
Sequence Analysis, DNA
Virus Replication
Lung
Disease Models, Animal
Immunosuppressive Agents
Agents that suppress immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-CELLS or by inhibiting the activation of HELPER CELLS. While immunosuppression has been brought about in the past primarily to prevent rejection of transplanted organs, new applications involving mediation of the effects of INTERLEUKINS and other CYTOKINES are emerging.
Interferon-gamma
The major interferon produced by mitogenically or antigenically stimulated LYMPHOCYTES. It is structurally different from TYPE I INTERFERON and its major activity is immunoregulation. It has been implicated in the expression of CLASS II HISTOCOMPATIBILITY ANTIGENS in cells that do not normally produce them, leading to AUTOIMMUNE DISEASES.
Microbial Sensitivity Tests
DNA, Ribosomal
Drug Therapy, Combination
Host Specificity
Invasive Pulmonary Aspergillosis
Cells, Cultured
Host-Pathogen Interactions
Host-Parasite Interactions
Rhodococcus equi
Toxoplasma
In vitro and in vivo activities of NS-718, a new lipid nanosphere incorporating amphotericin B, against Aspergillus fumigatus. (1/2546)
We evaluated the in vitro and in vivo potencies of a new lipid nanosphere that incorporates amphotericin B (AmB), NS-718, against Aspergillus fumigatus. The in vitro activity of NS-718 (the MIC at which 90% of strains are inhibited [MIC90], 0.25 microgram/ml) against 18 isolates of A. fumigatus was similar to that of deoxycholate AmB (D-AmB; Fungizone; MIC90, 0.25 microgram/ml), but NS-718 was more potent than liposomal AmB (L-AmB; AmBi-some; MIC90, 1.0 microgram/ml). The in vivo efficacy of NS-718 in a rat model of invasive pulmonary aspergillosis was compared with those of D-AmB and L-AmB. A low dose (1 mg/kg of body weight) of L-AmB was ineffective (survival rate, 0%), although equivalent doses of D-AmB and NS-718 were more effective (survival rate, 17%). However, a higher dose of NS-718 (3 mg/kg) was more effective (survival rate, 100%) than equivalent doses of D-AmB and L-AmB (survival rate, 0%). To explain these differences, pharmacokinetic studies showed higher concentrations of AmB in the plasma of rats treated with NS-718 than in the plasma of those treated with D-AmB. Our results suggest that NS-718, a new preparation of AmB, is a promising antifungal agent with activity against pulmonary aspergillosis. (+info)International travel and vaccinations. (2/2546)
With the increase in global travel, no disease is beyond the reach of any population. Traveling patients should be advised to follow food and water precautions and encouraged to receive the recommended immunizations. Travel medicine plays a vital role not only in limiting the morbidity of travel-related illnesses but also in limiting the spread of diseases. This article addresses the common issues related to travel, reviews the care of the immunocompromised traveler, and updates the available vaccinations and prophylactic regimens available to limit sickness abroad. (+info)Amebic liver abscess: epidemiology, clinical features, and outcome. (3/2546)
Amebic liver abscess (ALA) is a serious, but readily treatable form of hepatic infection. In order to understand the clinical features of this condition in the United States, we reviewed the medical histories of 56 patients with ALA at two large San Francisco Hospitals from 1979 to 1994. Patients were divided into the following groups based on the presumed manner in which they had acquired ALA: those born or raised in the United States, with a history of travel to an endemic area (Tr-ALA); those from an endemic area, but living in the United States for less than one year (En-ALA); and those neither from nor having traveled to an endemic area (N-ALA). We found distinct clinical patterns in patients from different epidemiological groups. Patients with Tr-ALA were a decade older than those from endemic regions, were more likely to be male, and tended to have an insidious onset. Furthermore, compared to patients with En-ALA, those with Tr-ALA were more likely to have hepatomegaly (P < 0.0001) and large abscesses (ALA > 10 cm; P < 0.01). One third of the patients studied had no associated travel history or endemic origin as risk factors. Of these, 63% had a condition consistent with severe immunosuppression, such as infection with the human immunodeficiency virus (HIV), malnourishment with severe hypoalbuminemia, or chronic infection. In patients with N-ALA, the presence of a presumed immunosuppressed state increased significantly, as compared to patients with endemic or travel risk factors for ALA. During the last five years of the study, one third of all patients diagnosed with ALA were HIV positive (including 2 with a new diagnosis of AIDS), many of whom were discovered to be HIV-infected only after presentation with ALA. We conclude that travel to and origin in an endemic area are important risk factors for the development of ALA, and patients in these different epidemiological groups appear to have distinct clinical features. Further, in the absence of recognized risk factors, the development of ALA may suggest an immunocompromised host. (+info)Actinomyces and nocardia infections in immunocompromised and nonimmunocompromised patients. (4/2546)
A retrospective survey of nocardia and actinomyces infections in five local hospitals was conducted over a 3-year period in El Paso, Texas, a border city, in the southwestern United States. The medical records of 42 patients with suspected nocardiosis or actinomycosis were reviewed. One patient was diagnosed with actinomyces and 12 patients with nocardia. Microbiological data included morphologic characteristics, biochemical profile, and susceptibility testing. Predisposing factors included leukemia, renal insufficiency, renal transplant, and lymphoma. No predisposing factors were found in 67% (n = 8) of patients (including the patient with actinomycosis). Twenty-three percent (n = 3) of patients had disseminated disease without evidence of underlying disease or immunosuppression. The mortality and morbidity of these infections appeared to be low. (+info)Restricted isotypic antibody reactivity to hepatitis C virus synthetic peptides in immunocompromised patients. (5/2546)
An enzyme immunoassay based on three synthetic peptides from the core, NS4, and NS5 regions of hepatitis C virus allowed the detection of antibodies in 100% of immunocompetent infected patients and in 91% of immunocompromised patients (hemodialysis and hemophiliac patients). Immune impairment seemed to restrict the spectrum of antibody isotypes reacting to the core peptide. (+info)Fatal disseminated Trichoderma longibrachiatum infection in an adult bone marrow transplant patient: species identification and review of the literature. (6/2546)
Trichoderma longibrachiatum was recovered from stool surveillance cultures and a perirectal ulcer biopsy specimen from a 29-year-old male who had received an allogeneic bone marrow transplant for acute lymphoblastic leukemia. The amphotericin B (2.0 microgram/ml) and itraconazole (1.0 microgram/ml) MICs for the organism were elevated. Therapy with these agents was unsuccessful, and the patient died on day 58 posttransplantation. At autopsy, histologic sections from the lungs, liver, brain, and intestinal wall showed infiltration by branching septate hyphae. Cultures were positive for Trichoderma longibrachiatum. While Trichoderma species have been recognized to be pathogenic in profoundly immunosuppressed hosts with increasing frequency, this is the first report of probable acquisition through the gastrointestinal tract. Salient features regarding the identification of molds in the Trichoderma longibrachiatum species aggregate are presented. (+info)Human rabies prevention--United States, 1999. Recommendations of the Advisory Committee on Immunization Practices (ACIP). (7/2546)
These revised recommendations of the Advisory Committee on Immunization Practices update the previous recommendations on rabies prevention (MMWR 1991;40[No.RR-3]:1-14) to reflect the current status of rabies and antirabies biologics in the United States. This report includes new information about a human rabies vaccine approved for U.S. use in 1997, recommendations regarding exposure to bats, recommendations regarding an observation period for domestic ferrets, and changes in the local administration of rabies immune globulin. (+info)Candida dubliniensis candidemia in patients with chemotherapy-induced neutropenia and bone marrow transplantation. (8/2546)
The recently described species Candida dubliniensis has been recovered primarily from superficial oral candidiasis in HIV-infected patients. No clinically documented invasive infections were reported until now in this patient group or in other immunocompromised patients. We report three cases of candidemia due to this newly emerging Candida species in HIV-negative patients with chemotherapy-induced immunosuppression and bone marrow transplantation. (+info)
Respiratory syncytial virus pneumonitis in immunocompromised adults: clinical features and outcome
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Albendazole
St Georgiev V (1997). Infectious Diseases in Immunocompromised Hosts. CRC Press. p. 695. ISBN 978-0-8493-8553-7. Riviere JE, ... is found in higher concentrations in the infected host tissues, and is found in higher concentrations within the parasites ...
Exophiala dermatitidis
1998). Infectious diseases in immunocompromised hosts. Boca Raton: CRC Press. p. 909. ISBN 0849385539. Retrieved 16 October ... The host responses are highly variable, often include cyst formation, and vary from weak reaction to an intense inflammatory ... and host factors such as immunological differences may be responsible for the different infection patterns. Exophiala ...
Microascus manginii
Scopulariopsis candida has been identified as the cause of some invasive infections, often in immunocompromised hosts, but is ... "Invasive scopulariopsis in the immunocompromised host". The American Journal of Medicine. 83 (6): 1163-1166. doi:10.1016/0002- ... The patient was immunocompromised at the time of fungal infection due to ongoing cancer treatment. The clinical presentation ... marked the first successful treatment of an invasive infection caused by Scopulariopsis species in an immunocompromised host. ...
Clostridium cadaveris
Gucalp, R.; Carlisle,Dutcher,Fuks,Wiernik (1993). "Clostridium cadaveris bacteremia in the immunocompromised host". Med. ... Most cases reported in medical literature document infections in immunocompromised patients, but isolated cases in ... "Clostridium cadaveris in an Immunocompetent Host". Clinical Infectious Diseases. 29 (5): 1354-1355. doi:10.1086/313491. PMID ... immunocompetent hosts have been reported. Primary isolation media is blood agar incubated anaerobically at 35-37 degrees ...
Human papillomavirus infection
Diagnostic Microbiology of the Immunocompromised Host (Second ed.). American Society of Microbiology. 4 (4): 177-195. doi: ... E6 produces a protein (also called E6) that binds to and inactivates a protein in the host cell called p53. Normally, p53 acts ... Virions can then be sloughed off in the dead squames of the host epithelium and the viral lifecycle continues. A 2010 study has ... HPV can survive for many months and at low temperatures without a host; therefore, an individual with plantar warts can spread ...
Fungal folliculitis
This disease commonly affects both immunocompetent and immunocompromised hosts. However, immunocompromised individuals have a ... The fungi are usually unable to penetrate into viable tissues in an immunocompetent host and therefore the infection incidence ... fluctuant subcutaneous nodules or abscesses represent a second form of MG that is generally observed in immunosuppressed hosts ... that usually occurs in healthy individuals deep subcutaneous plaque/nodular lesion form that occurs in immunosuppressed hosts. ...
Arcobacter ebronensis
"Bacteremia caused by Arcobacter butzleri in an immunocompromised host." Journal of Clinical Microbiology 53.4 (2015): 1448-1451 ...
Balamuthia mandrillaris
Mannan Baig, Abdul (Dec 2014). "Granulomatous amoebic encephalitis: ghost response of an immunocompromised host?". J Med ... Pathogenesis of amoebic encephalitis: Are the amoebas being credited to an 'inside job' done by the host immune response? Acta ... This granulomatous feature is mostly seen in immunocompetent patients; immunocompromised individuals exhibit a "perivascular ...
Acanthamoeba
Baig AM (December 2014). "Granulomatous amoebic encephalitis: ghost response of an immunocompromised host?". Journal of Medical ... The combination of host immune responses and secreted amoebal proteases causes massive brain swelling resulting in death in ... Members of the genus Acanthamoeba are unusual in serving as hosts for a variety of giant viruses (that have more than 1000 ... The exact nature of these symbionts and the benefit they represent for the amoebic host still have to be clarified. These ...
List of human disease case fatality rates
... ghost response of an immunocompromised host?". Journal of Medical Microbiology. 63 (Pt 12): 1763-1766. doi:10.1099/jmm.0.081315 ...
Lymphocyte T-cell immunomodulator
"Immune-enhancing agent for therapeutic use in immunocompromised hosts (US5616554A)". Google Patent. 26 July 1994. Retrieved 4 ...
Dimitrios Kontoyiannis
Kontoyiannis is the past president-elect of Immunocompromised Host Society (2016-2018) Kontoyiannis was recently named a fellow ... CS1 maint: discouraged parameter (link) "International Immunocompromised Host Society - home". ichs.org. "American Association ...
Varicella vaccine
Pirofski LA, Casadevall A (January 1998). "Use of licensed vaccines for active immunization of the immunocompromised host". ... mainly in inadvertently vaccinated immunocompromised children) as well as anaphylaxis. The possible mild side effects include ...
Cocooning (immunization)
"2013 IDSA Clinical Practice Guideline for Vaccination of the Immunocompromised Host". Clinical Infectious Diseases. 58 (3): e44 ... However, some attenuated vaccines are not recommended for people living with immuno-compromised people, depending on the ... "MODULE 2 - Immunizing the immunocompromised - WHO Vaccine Safety Basics". vaccine-safety-training.org. World Health ... People who are severely immuno-compromised may not be able to take some vaccines; on the other hand, they may be much more ...
Nocardia asteroides
It can cause nocardiosis, a severe pulmonary infection in immunocompromised hosts. Roth A, Andrees S, Kroppenstedt RM, Harmsen ...
Corynebacterium
Some attack healthy hosts, while others tend to attack the immunocompromised. Effects of infection include granulomatous ... or weakened host defenses. The genus Corynebacterium was created by Lehmann and Neumann in 1896 as a taxonomic group to contain ... neutropenic or immunocompromised patients, and those with prosthetic devices such as prosthetic heart valves, shunts, or ... most commonly existing in commensal relationships with their hosts. Some are useful in industrial settings such as C. ...
Immune system
Joos L, Tamm M (2005). "Breakdown of pulmonary host defense in the immunocompromised host: cancer chemotherapy". Proceedings of ... providing a direct route for proteins to move from the pathogen to the host. These proteins are often used to shut down host ... Masking antigens with host molecules is another common strategy for avoiding detection by the immune system. In HIV, the ... The innate immune system is the dominant system of host defense in most organisms, and the only one in plants. Cells in the ...
Hairy leukoplakia
Uncontrolled lytic infection is manifested as oral hairy leukoplakia in immunocompromised hosts. OHL usually arises where the ... OHL may also accompany chronic graft versus host disease. Even more rare are reports of OHL in persons with competent immune ... It is caused by Epstein-Barr virus (EBV) and occurs usually in persons who are immunocompromised, especially those with human ... the virus will persist for the rest of the host's life and "hides" from the immune system by latent infection of B lymphocytes ...
Trichodysplasia spinulosa polyomavirus
... a newly described folliculocentric viral infection in an immunocompromised host". The Journal of Investigative Dermatology. ... TSPyV has been associated with disease only in severely immunocompromised individuals, and then only in a small minority of ... Trichodysplasia spinulosa is a proliferative skin disorder that occurs in immunocompromised people and is considered benign, ... 2010). "Discovery of a New Human Polyomavirus Associated with Trichodysplasia Spinulosa in an Immunocompromized Patient". PLOS ...
Trichodysplasia spinulosa
... a newly described folliculocentric viral infection in an immunocompromised host". The Journal of Investigative Dermatology. ... This pattern is consistent with the behavior of other viral diseases found in immunocompromised patients, most relevantly with ... TS has been reported almost exclusively in immunocompromised patients, primarily organ transplant recipients on regimens of ... is a rare cutaneous condition that has been described almost exclusively in immunocompromised patients, usually organ ...
Tuberculosis in relation to HIV
Airborne transmission typically causes TB infection in both immunocompetent and immunocompromised hosts.[citation needed] ... Tuberculosis is the most common contagious infection in HIV-Immunocompromised patients leading to death. These diseases act in ...
Eikenella corrodens
E. corrodens could independently cause serious infection in both immunocompetent and immunocompromised hosts. Eikenella ...
Panophthalmitis
... and ecthyma gangrenosum in an immunocompromised host with pseudomonas septicemia". American Journal of Ophthalmology. 137 (1): ...
Rituximab
... and NK-Cell Derivation in Non-Immunocompromised Hosts". Pathogens (Basel, Switzerland). 7 (1): 28. doi:10.3390/pathogens7010028 ...
Epstein Barr virus positive diffuse large B-cell lymphoma, not otherwise specified
... and NK-Cell Derivation in Non-Immunocompromised Hosts". Pathogens (Basel, Switzerland). 7 (1): 28. doi:10.3390/pathogens7010028 ...
Diffuse large B-cell lymphoma associated with chronic inflammation
... and NK-Cell Derivation in Non-Immunocompromised Hosts". Pathogens (Basel, Switzerland). 7 (1): 28. doi:10.3390/pathogens7010028 ... a protein that helps these cells avoid attack by host cytotoxic T-cells and also blocks their apoptosis responses thereby ... antibody that binds to the CD20 cell surface protein on B-cells to thereby target these cells for attack by the hosts adaptive ...
Sporothrix schenckii
Inhalation of spores is a rare route of infection largely associated with immunocompromised hosts. The cutaneous form of ... In host tissue it is found as a yeast. The transition between the hyphal and yeast forms is temperature dependent making S. ... Growing at host body temperature (37 °C (99 °F)) is an important requirement for pathogenesis. Some strains of S. schenckii are ... Immunocompromised individuals are at increased risk of infection and such patients often exhibit more severe forms of disease. ...
Diffuse large B-cell lymphoma
... and NK-Cell Derivation in Non-Immunocompromised Hosts". Pathogens (Basel, Switzerland). 7 (1): 28. doi:10.3390/pathogens7010028 ... that express high levels of CD20 by binding to this cell-surface protein and thereby targeting them for attack by the hosts ...
Plasmablastic lymphoma
... and NK-Cell Derivation in Non-Immunocompromised Hosts". Pathogens (Basel, Switzerland). 7 (1): 28. doi:10.3390/pathogens7010028 ... These RNAs promote infected cells to proliferate, avoid attack by the host's immune system's cytotoxic T-cells, and, possibly, ... avoid the host's immune surveillence; survive for prolonged periods, grow excessively, and acquire pro-malignant gene ...
Acinetobacter lwoffii
It can cause infections in human hosts, particularly catheter-associated infections in immunocompromised patients. It has also ...
Oral candidiasis
The prevalence is roughly equal in healthy individuals, but type B is more prevalent in immunocompromised individuals. The host ... Patients who are immunocompromised, either with HIV/AIDS or as a result of chemotherapy, may require systemic treatment with ... This candidal carriage state is not considered a disease, but when Candida species become pathogenic and invade host tissues, ... When Candida species cause lesions - the result of invasion of the host tissues - this is termed candidiasis. Some consider ...
Caliciviridae
Entry into the host cell is achieved by attachment to host receptors, which mediates endocytosis. Replication follows the ... Most calicivirus infections do not call for medical attention, but those who are immunocompromised may need to be hospitalized ... Vertebrates serve as the natural host. Transmission routes are fecal-oral. Calicivirus infections commonly cause acute ... making this animal species of particular interest in the study of calicivirus pathogenesis and host range. The first mouse ...
Index of HIV/AIDS-related articles
... host - host factors - HPTN - HPV - HRSA - HTLV-I - HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP) - HTLV- ... immunocompromised - immunodeficiency - immunogen - immunogenicity - immunoglobulin (Ig) - immunoglobulin A (IgA) - ...
Gas gangrene
When such bacteria are able to enter a living host, they encounter a vast supply of nutrients, warm conditions, and an ... "Gas gangrene in an immunocompromised girl due to a Clostridium ramosum infection". Clin. Infect. Dis. 28 (4): 923-4. doi ... Massive infection, gross injury, and depletion of the host's immune capability result in system-wide sepsis. This is partly due ... as prokaryotic bacteria possess a far greater capacity for multiplication than the host's immune system. The combination of ...
Zoonosis
Because they depend on the human host for part of their life-cycle, diseases such as African schistosomiasis, river blindness, ... and is an important opportunistic pathogen in people immunocompromised by HIV/AIDS, organ transplantation, or CD4+ T-lymphocyte ... ingestion of infective eggs from contaminated food or water with feces of an infected, definitive host or fur ... Zoonoses are infectious diseases which jump from an animal host or reservoir into humans.. ...
Mold health issues
In 2003, The Tonight Show co-host Ed McMahon received $7.2 million from insurers and others to settle his lawsuit alleging that ... A serious health threat from mold exposure for immunocompromised individuals is systemic fungal infection (systemic mycosis). ... such as Penicillium marneffei and Aspergillus fumigatus is a common cause of illness and death among immunocompromised people, ... Immunocompromised individuals exposed to high levels of mold, or individuals with chronic exposure may become infected.[23][24] ...
Influenza
... immunocompromised hosts, and nursing home residents" (PDF). J Infect Dis. 194 S2: S133-38. doi:10.1086/507548. PMID 17163386. ... Host cell invasion and replication by the influenza virus. The steps in this process are discussed in the text. ... These sudden large changes allow the virus to infect new host species and quickly overcome protective immunity.[68] This is ... Hayden FG (March 1997). "Prevention and treatment of influenza in immunocompromised patients". Am. J. Med. 102 (3A): 55-60, ...
Tapeworm infection
In at least one case, cancer cells from a tapeworm spread to the human host in an immunocompromised man, producing swelling, ... 2015), "Malignant transformation of Hymenolepis nana in a human host", N Engl J Med, 373: 1845-1852, doi:10.1056/NEJMoa1505892. ... Tapeworms of the genus Echinococcus infect and cause the most harm to intermediate hosts such as sheep and cattle. Infection ... Unlike other tapeworms, the dwarf tapeworm can complete its entire life cycle - egg to larva to adult tapeworm - in one host. ...
Periodontology
An individual's host response plays an important role in the pathogenesis of periodontal disease. Even in a mouth where the ... In the case of an immunocompromised patient antibiotics should be prescribed. Assessment of treatment should be done after 24 ... This results in the imbalance between host and bacterial factors which can in turn result in a change from health to disease. ... Genetics and the Host response have been shown to play an important role in periodontal disease development in studies on ...
Thymus
Autoimmune diseases are caused by a hyperactive immune system that instead of attacking pathogens reacts against the host ... and upon transplantation it was able to restore immune function in immunocompromised mice. The mouse embryonic fibroblasts were ... It effectively protects the host from various infections. An improperly functioning immune system can cause discomfort, disease ... a graft-versus-host-like disease". J Am Acad Dermatol. 57 (4): 683-9. doi:10.1016/j.jaad.2007.02.027. PMID 17433850. Kumar, ...
Cutaneous leishmaniasis
Dogs and rodents serve as the primary animal reservoir hosts in the sylvatic cycle, but people with chronic PKDL can also serve ... and immunocompromised patients have not been well established.[19] ... as important reservoir hosts for cutaneous leishmaniasis.[23] The most common vectors for cutaneous leishmaniasis in the Old ...
Sepsis
Host factors[edit]. Upon detection of microbial antigens, the host systemic immune system is activated. Immune cells not only ... but fever may be absent in some people such as the elderly or those who are immunocompromized.[19] ... By the end of the 19th century, it was widely believed that microbes produced substances that could injure the mammalian host ... Rather it is often an adaptive microbial response to a sudden decline of host survival chances. Under this scenario, the ...
Zoonosis
Because they depend on the human host for part of their life-cycle, diseases such as African schistosomiasis, river blindness, ... and listeriosis in pregnant or the otherwise immunocompromised. Echinococcosis is caused by a tapeworm which can be spread from ... ingestion of infective eggs from contaminated food or water with feces of an infected, definitive host and/or fur. ... the human is actually better viewed as an accidental or incidental victim and a dead-end host. Examples include rabies, anthrax ...
Infection
Entrance to the host at host-pathogen interface, generally occurs through the mucosa in orifices like the oral cavity, nose, ... The patient is immunocompromised (for example, in AIDS or after chemotherapy);. *The infectious agent is of an uncommon nature ... The intermediate host comes in contact during the larvae stage. A host can be anything living and can attain to asexual and ... Hosts can fight infections using their immune system. Mammalian hosts react to infections with an innate response, often ...
Agrobacterium
The plasmid T-DNA is integrated semi-randomly into the genome of the host cell,[7] and the tumor morphology genes on the T-DNA ... "Recovery of a strain of Agrobacterium radiobacter with a mucoid phenotype from an immunocompromised child with bacteremia" ...
Aphthous stomatitis
Immunocompromised states, e.g. HIV/AIDS. Inflammatory bowel disease. MAGIC syndrome. PFAPA syndrome. Reactive arthritis. ... Risk factors in aphthous stomatitis are also sometimes considered as either host-related or environmental.[7] ...
Cyclophosphamide
Thus, cyclophosphamide preconditioning of recipient hosts (for donor T cells) has been used to enhance immunity in naïve hosts ... Particularly for bacteria with potential consumer exposure they require testing of the microbe on immuno-compromised rats [53] ... Elimination of T regulatory cells (CD4+CD25+ T cells) in naive and tumor-bearing hosts ...
Chickenpox
Exposure to VZV in a healthy child initiates the production of host immunoglobulin G (IgG), immunoglobulin M (IgM), and ... Disseminated primary varicella infection usually seen in the immunocompromised may have high morbidity. Ninety percent of cases ... Hemorrhagic complications are more common in the immunocompromised or immunosuppressed populations, although healthy children ... can occur in immunocompromised individuals, although the risk is higher with herpes zoster.[61] Necrotizing fasciitis is also a ...
Xenotransplantation
Antigens of phagocytosed graft cells can also be presented by the host's class I MHC molecules to CD8+ T cells.[1][29] ... Xenotransplantation of human tumor cells into immunocompromised mice is a research technique frequently used in pre-clinical ... A rapid, violent, and hyperacute response comes as a result of antibodies present in the host organism. These antibodies are ... Binding of the previously mentioned XNAs to the donor endothelium leads to the activation of host macrophages as well as the ...
Yeast
Cryptococcus neoformans and Cryptococcus gattii are significant pathogens of immunocompromised people. They are the species ... and even deep-sea environments host an array of yeasts.[31][32] ...
Pathogen
A bacterium may participate in opportunistic infections in immunocompromised hosts, acquire virulence factors by plasmid ... Virulence (the tendency of a pathogen to reduce a host's fitness) evolves when a pathogen can spread from a diseased host, ... They can either directly affect the cells of their host, produce endotoxins that damage the cells of their host, or cause a ... despite the host becoming debilitated. Horizontal transmission occurs between hosts of the same species, in contrast to ...
Kaposi's sarcoma-associated herpesvirus
KSHV is a rhadinovirus, and is remarkable since it has stolen numerous genes from host cells including genes that encode for ... Kaposi's sarcoma occurs when someone who has been infected with KSHV becomes immunocompromised due to AIDS, medical treatment, ... The viral episome is chromatinized upon entry into the host cell nucleus.[15] LANA tethers the viral DNA to cellular ... July 2016). "Integrins as Herpersvirus Receptors and Mediators of the Host Signalosome". Reviews in Advance. 3 (1): 215-236. ...
Viral meningitis
... is mostly caused by an infectious agent that has colonized somewhere in its host.[15] People who are already ... in an immunocompromised state are at the highest risk of pathogen entry.[12] Potential sites for this include the skin, ... The organism invades the submucosa at these sites by invading host defenses, such as local immunity, physical barriers, and ...
Salmonella
Host adaptation[edit]. S. enterica, through some of its serotypes such as Typhimurium and Enteriditis, shows signs of the ... People who are at risk for severe illness include infants, elderly, organ-transplant recipients, and the immunocompromised.[38] ... Typhimurium from animal hosts.[75] The papA gene, which is unique to sv. Newport, contributes to the strain's fitness in ... Through the loss of the genetic material that codes for a flagellum to form, Salmonella can evade a host's immune system.[71] ...
Natural killer cell
In a study at Boston Children's Hospital, in coordination with Dana-Farber Cancer Institute, in which immunocompromised mice ... which requires that all T cells be removed before infusion into the patients to remove the risk of graft versus host disease, ...
Spanish flu
... as the hosts of more dangerous strains tend to die out[29] (see also "Deadly Second Wave", above). ... and the immunocompromised. In 1918, older adults may have had partial protection caused by exposure to the 1889-1890 flu ... An estimated date for its appearance in mammalian hosts has been put at the period 1882-1913.[108] This ancestor virus diverged ... "Using non-homogeneous models of nucleotide substitution to identify host shift events: application to the origin of the 1918 ' ...
Sistem imun bahasa Indonesia, ensiklopedia bebas
"Breakdown of pulmonary host defense in the immunocompromised host: cancer chemotherapy". Proc Am Thorac Soc. 2 (5): 445-8. PMID ... Agerberth B, Gudmundsson G. "Host antimicrobial defence peptides in human disease". Curr Top Microbiol Immunol. 306: 67-90. ... Finlay B, McFadden G (2006). "Anti-immunology: evasion of the host immune system by bacterial and viral pathogens". Cell. 124 ( ... "Phospholipase A(2) in rabbit tears: a host defense against Staphylococcus aureus". Invest Ophthalmol Vis Sci. 42 (10): 2347-54 ...
Transfusion-associated graft versus host disease
This can result in graft-versus-host disease. The incidence of TA-GvHD in immunocompromised patients receiving blood ... Transfusion-associated graft-versus-host disease (TA-GvHD) is a rare complication of blood transfusion, in which the donor T ... This testing can identify circulating lymphocytes with a different HLA type than the tissue cells of the host. Treatment is ... Full text Gupta, A; Bansal, D; Dass, R; Das, A (2004). "Transfusion Associated Graft versus Host Disease". Indian Pediatr. 41 ( ...
Setosphaeria rostrata
In this incident, E.rostratum became highly virulent in the host after inoculation of the fungus into the spine. The ... In most cases the patients were immunocompromised, several of the affected children had acute lymphoblastic leukemia (ALL). In ... However, S. rostrata has also been shown to survive in human as well as animal hosts, indicating pathogenic versatility. Though ... The cases of adults with cutaneous phaeohyphomycosis occurred mainly in immunocompromised patients as well. However, there are ...
Diagnosis of Cellulitis in the Immunocompromised Host
... Charles F Carey and Lawrence Dall ... of the blood cultures were positive in this immunocompromised population. The incidence of positive fine needle aspiration ... This study indicates that in the immunocompromised population with cellulitis, fine needle aspiration and blood cultures should ...
Vaccines in the Immunocompromised Hosts | SpringerLink
Vaccines in the Immunocompromised Hosts. In: Segal B. (eds) Management of Infections in the Immunocompromised Host. Springer, ... 2013 IDSA clinical practice guideline for vaccination of the immunocompromised host. Clin Infect Dis. 2014;58(3):309-18.PubMed ... Repeated vaccination is required to optimize seroprotection against H1N1 in the immunocompromised host. Haematologica. 2011;96( ... Management of Infections in the Immunocompromised Host pp 359-374 , Cite as ...
What are the signs and symptoms of acute toxoplasmosis in immunocompromised hosts?
Legionnaires Disease in Immunocompromised Host | IntechOpen
The symptoms of the disease are nonspecific requiring a high index of suspicion in vulnerable hosts, as effective treatment ... The reported incidence of Legionnaires disease is approximately 1.4-1.8 cases per 100,000 persons and immunocompromised state ... Sensitivity of urinary antigen testing is lower in immunocompromised patients because of higher likelihood of infections caused ... manifestations and higher mortality are particularly more common in immunocompromised patients than in immunocompetent hosts. ...
Influenza H1N1 infection in immunocompromised host: A concise review. - PubMed - NCBI
Influenza H1N1 infection in immunocompromised host: A concise review.. Harish MM1, Ruhatiya RS1. ... Influenza A (H1N1) infection has a propensity to infect an immunocompromised host (ICH). These patients experience more severe ... Extracorporeal membrane oxygenation in immunocompromised; influenza vaccine in immunocompromised; influenza-associated ...
Viral Infections in Healthy and Immunocompromised Hosts - Full Text View - ClinicalTrials.gov
Viral Infections in Healthy and Immunocompromised Hosts. Further study details as provided by National Institutes of Health ... Viral Infections in Healthy and Immunocompromised Hosts. This study is enrolling participants by invitation only. ... Immunocompromised persons often shed high titers of virus for prolonged periods of time. In the absence of a potent immune ... This study should provide further understanding on how viruses evolve in their natural hosts, how they become resistant to ...
List of 6 Herpes Simplex, Mucocutaneous/Immunocompromised Host Medications Compared - Drugs.com
Mucocutaneous/Immunocompromised Host. Find the most popular drugs, view ratings and user reviews. ... Mucocutaneous/Immunocompromised Host *Medication List. About Herpes Simplex, Mucocutaneous/Immunocompromised Host Herpes ... Drugs used to treat Herpes Simplex, Mucocutaneous/Immunocompromised Host The following list of medications are in some way ... Learn more about Herpes Simplex, Mucocutaneous/Immunocompromised Host. Drugs.com Health Center. *HIV and AIDS: Opportunistic ...
COVID-19 Infection Prevention for Immunocompromised Host - ISID
COVID-19 infection prevention is even more necessary for immunocompromised patients. ... COVID-19 Related Infection Prevention for the Immunocompromised Host. GUIDE TO INFECTION CONTROL IN THE HEALTHCARE SETTING. ... COVID-19 in Immunocompromised Hosts: What We Know So Far [published online ahead of print, 2020 Jun 27]. Clin Infect Dis. 2020; ... For immunocompromised hosts who have suspected or confirmed COVID-19 infection, key infection control practices include hand ...
Viral Infections in Healthy and Immunocompromised Hosts - No Study Results Posted - ClinicalTrials.gov
Isolated Cerebellar Abscess by Burkholderia pseudomallei in an Immunocompromised Host: A Rare Case. - PubMed - NCBI
The Potential Role of Recombinant Hematopoietic Colony-Stimulating Factors in Preventing Infections in the Immunocompromised...
Immunocompromised host | definition of immunocompromised host by Medical dictionary
What is immunocompromised host? Meaning of immunocompromised host medical term. What does immunocompromised host mean? ... Looking for online definition of immunocompromised host in the Medical Dictionary? immunocompromised host explanation free. ... immunocompromised host. See: immunocompromised. incidental host. Dead-end host.. intermediate host. 1. The host in which a ... accidental host. A host other than the usual or normal one. alternate host. Intermediate host (1).. compromised host. A person ...
The British Mycological Society :: The 20th symposium of the International Immunocompromised Host Society
We encourage all who are interested in the clinical practice and research on infections in immunocompromised host to attend the ... The 20th symposium of the International Immunocompromised Host Society * Cellular and Molecular Fungal Biology - Gordon ... The 20th symposium of the International Immunocompromised Host Society. Athens, Greece - http://www.ichs.org/2018-ICHS- ...
2013 Infectious Diseases Society of America Clinical Practice Guidelines for the Immunization of the Immunocompromised Host |...
2013 IDSA clinical practice guidelines for the immunization of the immunocompromised host. Clin Infect Dis. 2013; in press. ... 2013 Infectious Diseases Society of America Clinical Practice Guidelines for the Immunization of the Immunocompromised Host. ... 2013 Infectious Diseases Society of America Clinical Practice Guidelines for the Immunization of the Immunocompromised Host ... 2013 Infectious Diseases Society of America Clinical Practice Guidelines for the Immunization of the Immunocompromised Host ...
Infections in the Immunocompromised Host | Springer for Research & Development
Fungal and Parasitic Infections in the Immunocompromised Host - An Overview. * Fungal Infections in the Compromised Host - An ... The Immunocompromised Host - An Overview. * Epidemiologic and Clinical Aspects of Opportunistic Infections ... The first section dealt with the general subject of the immunocompromised host. Here, reviewed in detail, were the ... Bacterial and Viral Infections in the Compromised Host. * M.I.D.A.S. - An On-Line Microbiology Information System ...
Tula Hantavirus Infection in Immunocompromised Host, Czech Republic - Volume 19, Number 11-November 2013 - Emerging Infectious...
Zelená H, Mrázek J, Kuhn T. Tula Hantavirus Infection in Immunocompromised Host, Czech Republic. Emerging Infectious Diseases. ... Zelená H, Mrázek J, Kuhn T. Tula Hantavirus Infection in Immunocompromised Host, Czech Republic. Emerg Infect Dis. 2013;19(11): ... Zelená, H., Mrázek, J., & Kuhn, T. (2013). Tula Hantavirus Infection in Immunocompromised Host, Czech Republic. Emerging ... Tula Hantavirus Infection in Immunocompromised Host, Czech Republic. ...
Tula Hantavirus Infection in Immunocompromised Host, Czech Republic - Volume 19, Number 11-November 2013 - Emerging Infectious...
We report molecular evidence of Tula hantavirus as an etiologic agent of pulmonary-renal syndrome in an immunocompromised ... Zelená H, Mrázek J, Kuhn T. Tula Hantavirus Infection in Immunocompromised Host, Czech Republic. Emerging Infectious Diseases. ... Zelená H, Mrázek J, Kuhn T. Tula Hantavirus Infection in Immunocompromised Host, Czech Republic. Emerg Infect Dis. 2013;19(11): ... Zelená, H., Mrázek, J., & Kuhn, T. (2013). Tula Hantavirus Infection in Immunocompromised Host, Czech Republic. Emerging ...
A persistent challenge: the diagnosis of respiratory disease in the non-AIDS immunocompromised host | Thorax
A persistent challenge: the diagnosis of respiratory disease in the non-AIDS immunocompromised host ... A persistent challenge: the diagnosis of respiratory disease in the non-AIDS immunocompromised host ... A persistent challenge: the diagnosis of respiratory disease in the non-AIDS immunocompromised host ...
Viruses | Free Full-Text | Mouse Model of Cytomegalovirus Disease and Immunotherapy in the Immunocompromised Host: Predictions...
Any model for hCMV disease is, however, constrained by the strict host-species specificity of CMVs that prevents the study of ... hCMV causes multiple-organ disease and interstitial pneumonia in particular upon infection during the immunocompromised period ... Reddehase, M.J.; Lemmermann, N.A.W. Mouse Model of Cytomegalovirus Disease and Immunotherapy in the Immunocompromised Host: ... Mouse Model of Cytomegalovirus Disease and Immunotherapy in the Immunocompromised Host: Predictions for Medical Translation ...
Viruses | Free Full-Text | Mouse Model of Cytomegalovirus Disease and Immunotherapy in the Immunocompromised Host: Predictions...
Any model for hCMV disease is, however, constrained by the strict host-species specificity of CMVs that prevents the study of ... hCMV causes multiple-organ disease and interstitial pneumonia in particular upon infection during the immunocompromised period ... In the immunocompromised murine host, fibroblast-propagated mCMV, for instance, the prototypic Smith strain as well as BAC- ... The model, as discussed above, has documented control of mCMV infection in the immunocompromised murine host by adoptive ...
Sankar Swaminathan, MD - Immunocompromised Host , Infectious Diseases , Internal Medicine | University of Utah Health
2) We have shown that SM affects host cell RNA splicing. This effect of EBV on host cell splicing, by altering the levels of ... The SM protein acts by pirating components of the host cell to facilitate expression of EBV genes and also modulates host gene ... The second major area of research is to understand the role of the proteins produced by the host cell in response to interferon ... Li DJ, Verma D, Mosbruger T, Swaminathan S (2014). CTCF and Rad21 act as host cell restriction factors for Kaposis sarcoma- ...
Pulmonary Infections in the HIV-Negative, Immunocompromised Host - The Clinical Advisor
While the vaccine may not be as immunogenic in immunocompromised hosts as in normal hosts, numerous series show that at least ... Important noninfectious etiologies in the HIV-negative, immunocompromised host include graft versus host disease and/or ... immunocompromised host? * If you decide the HIV-negative, immunocompromised patient has a pulmonary infection, how should the ... immunocompromised host?. Most immunocompromised patients with pulmonary symptoms have a chest x-ray. It may be helpful for most ...
OSH Infection in the Immunocompromised Host - Simon Fox, Brian Angus, Angela Minassian, Thomas Rawlinson - Oxford University...
There is an increasing number of immunocompromised patients across a widening range of specialities in medicine. Patients with ... OSH Infection in the Immunocompromised Host. Simon Fox, Brian Angus, Angela Minassian, and Thomas Rawlinson. Oxford Specialist ... OSH Infection in the Immunocompromised Host. Simon Fox, Brian Angus, Angela Minassian, and Thomas Rawlinson. Oxford Specialist ... OSH Infection in the Immunocompromised Host. Simon Fox, Brian Angus, Angela Minassian, and Thomas Rawlinson. Oxford Specialist ...
Deficient expression of bactericidal/permeability-increasing protein in immunocompromised hosts: translational potential of...
Deficient expression of bactericidal/permeability-increasing protein in immunocompromised hosts: translational potential of ... Deficient expression of bactericidal/permeability-increasing protein in immunocompromised hosts: translational potential of ... antibody (Ab), bactericidal/permeability-increasing protein (BPI), cystic fibrosis (CF), host defence, lipoxin (LX) ... Innate mammalian host defence against infection is based on rapid immune detection and effector mechanisms that target ...
International Immunocompromised Host Society - home
Prof Slavin received training in clinical research in infection in immunocompromised hosts in Seattle 1989-92 where she ... the ICHS Council have made the decision to postpone the 21st ICHS Symposium on Infections in the Immunocompromised Host. ... Director of the Department of Infectious Diseases Peter MacCallum Cancer Centre and leads the Immunocompromised Host Infection ...
International Immunocompromised Host Society - Society History
The International Immunocompromised Host Society (ICHS) began as a group of like-minded physicians interested in providing ... 7th International Symposia on Infections in the Immunocompromised Host: 1992 Boulder, CO USA: President - Jan Verhoef, The ... 11th International Symposia on Infections in the Immunocompromised Host: 2000 Halifax, Canada: President - Phil Pizzo, USA ... 19th International Symposium on Infections in the Immunocompromised Host 2016 Santiago, Chile; President - Thomas F. Patterson ...
International Immunocompromised Host Society - Conference Schedule
International Immunocompromised Host Society - Abstracts & Posters
By submission of your abstract you agree that the abstract will be published freely online under a Creative Commons license (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.de) on the medical publication portal German Medical Science (http://www.egms.de/). By the use of this license, copyright remains completely with the authors. Only a one-time right for online publication is transferred to German Medical Science.. Furthermore, we assume that the content of the submitted abstract has not been published previously in this form and that it is not under consideration for presentation elsewhere. Responsibility for clearance of any third party copyright on any material included in the abstract is with the authors. Please also note that your text will be published as originally submitted, i.e. no copy editing by German Medical Science or proofreading by the authors prior to publication will be possible.. ...
Infection in the Immunocompromised Host Flashcards by Alice Raban | Brainscape
Infection in the immunocompromised host - Oxford Medicine
... immunocompromised host embraces a group of overlapping conditions in which the ability to respond normally to an infective ... Infection in the immunocompromised host Infection in the immunocompromised host. Chapter:. Infection in the immunocompromised ... The term immunocompromised host embraces a group of overlapping conditions in which the ability to respond normally to an ... 7.1 Pathogenic microorganisms and the host*7.1.1 Biology of pathogenic microorganisms ...
International Immunocompromised Host SocietyInfections in the immunocompromisedIncreasing number of immunocompromised patientsPatientsInfection in immunocompromised hostsClinicalVaccinationVaccine in immunocompromisedPneumoniaFungal InfectionsSepsisTransplant recipientsVaccinesSeverePathogenesisToxoplasmosisInnateVirusesImmunityRespiratoryObserved in immunocompetent hostsInvasive fungalGraftInfluenza vaccineAcuteCandidiasisImmuneViralPatientSyndromeImmunotherapyMonica SlavinTreatmentManifestationsPathogensTuberculosisClinically
International Immunocompromised Host Society2
Infections in the immunocompromised1
- After careful consideration and in response to the continuing developments surrounding COVID-19, the ICHS Council have made the decision to postpone the 21st ICHS Symposium on Infections in the Immunocompromised Host. (ichs.org)
Increasing number of immunocompromised patients2
- There is an increasing number of immunocompromised patients across a widening range of specialities in medicine. (oup.com)
- Their incidence is growing because of the increasing number of immunocompromised patients. (biomedsearch.com)
Patients28
- Humoral response to the influenza A H1N1/09 monovalent AS03-adjuvanted vaccine in immunocompromised patients. (springer.com)
- Sensitivity of urinary antigen testing is lower in immunocompromised patients because of higher likelihood of infections caused non L. pneumophila species. (intechopen.com)
- Extrapulmonary manifestations and higher mortality are particularly more common in immunocompromised patients than in immunocompetent hosts. (intechopen.com)
- Although Legionnaire's disease is commonly reported in immunocompetent patients, immunocompromised state, particularly impaired cellular immunity is an independent risk factor for legionella infection. (intechopen.com)
- COVID-19 Infection Prevention for the Immunocompromised Host: The COVID-19 pandemic has not spared any nation or group, though has perhaps most severely affected patients with compromised immune systems, including people living with HIV, cancer patients, transplant recipients, or those taking immune suppressing medications for autoimmune conditions. (isid.org)
- 5 Many of these immunocompromised patients also have significant healthcare exposures resulting in potentially increased exposure risk to COVID-19, and also have other comorbidities known to increase the risk of severe COVID-19 infection, such as hypertension, cardiovascular disease, diabetes, or lymphopenia. (isid.org)
- His main clinical focus is in the diagnosis and treatment of infections in immunocompromised patients, including cancer patients and transplant recipients. (utah.edu)
- Pulmonary infections in HIV-negative, immunocompromised hosts occur frequently and are among the most common infectious complications in these patients. (clinicaladvisor.com)
- The Oxford Specialist Handbook of Infection in the Immunocompromised Host is a comprehensive guide for medical staff caring for immunocompromised patients in a hospital setting. (oup.com)
- The use of molecular detection techniques, such as PCR, were shown to be of great value in the diagnostic and epidemiological determination of herpesviral infection in immunocompromised patients. (ucl.ac.uk)
- Invasive aspergillosis (IA) and candidemia are an increasing cause of morbidity and mortality in immunocompromised patients, but diagnostic procedures are often hampered by critical patients conditions. (pagepressjournals.org)
- International Travel in the Immunocompromised Patient A cross-sectional survey of travel advice in 254 consecutive patients.International Travel in the Immunocompromised Patient A cross-sectional survey of travel advice in 254 consecutive patients. (monashhealth.org)
- Our transplant and immunocompromised host service, directed by Jay Fishman, MD , has always worked in a multidisciplinary fashion with others involved in the care of these complicated patients. (massgeneral.org)
- Infrequently, lung biopsy is required to establish a diagnosis in very ill patients, who often are immunocompromised. (medscape.com)
- PIV pneumonia: Treatment is mainly supportive, but aerosolized and oral ribavirin have been associated with reduction in PIV shedding and clinical improvement in immunocompromised patients. (medscape.com)
- Increasing opportunities for travel and advances in medicine mean that immunocompromised patients may venture to potentially risky parts of the world. (ox.ac.uk)
- FluMist) may offer a more effective alternative to TIV, but the safety of this LAIV in immunocompromised patients must first be established. (nih.gov)
- Current strategies in the treatment of invasive Aspergillus infections in immunocompromised patients. (biomedsearch.com)
- Restoration of host immune defences by tapering of immunosuppressive therapy in transplant patients or correction of granulocytopenia in haematological disease is the cornerstone of modern treatment of aspergillosis in immunocompromised patients. (biomedsearch.com)
- Thirty-one immunocompromised patients with severe cytomegalovirus (CMV) disease were treated with intravenous ganciclovir. (jamanetwork.com)
- Twenty-one patients had received transplants-15 bone marrow recipients, five renal allograft recipients, and one liver transplant recipient-while the other ten were immunocompromised due to acquired immunodeficiency syndrome (six), hematologic malignancies (three), and systemic lupus erythematosus (one). (jamanetwork.com)
- The aim of this study was to compare the clinical manifestations, biochemical tests, radiologic features and pathological findings of hepatic tuberculosis in immunocompromised and immunocompetent patients. (bvsalud.org)
- There were 12 immunocompromised patients (10 HIV-infected males, 1 systemic lupus erythematosus (SLE) male, 1 SLE female) and 8 immunocompetent patients (6 males, 2 females). (bvsalud.org)
- To evaluate the safety and efficacy of itraconazole oral solution versus fluconazole tablets for the treatment of esophageal candidiasis in immunocompromised patients. (clinicaltrials.gov)
- To determine the safety, toleration, and efficacy of fluconazole oral suspension in the treatment of esophageal candidiasis in immunocompromised patients, including those with AIDS. (clinicaltrials.gov)
- One of the biggest concerns associated with S. pneumoniae infection is its high mortality in immunocompromised patients such as elderly, neonatal, and immunosuppressed patients ( Lynch and Zhanel, 2010 ). (frontiersin.org)
- With two new faculty hires, the new service will provide specialized care to immunocompromised patients with unusual infections that require special expertise. (unchealthcare.org)
- Characterization of the role of candidate chemotactic factors in antifungal host defense in mice is then followed by human immunogenomics studies, in which genetic polymorphisms in the identified chemotactic factor genes are tested for correlating effects on biological function and for associations with candidiasis in patients. (nih.gov)
Infection in immunocompromised hosts2
- Examples include respiratory syncytial virus (RSV) or adenovirus, which might manifest as an upper respiratory tract infection of minimal consequence in those with normal immune systems but might cause life-threatening disseminated infection in immunocompromised hosts. (clinicaladvisor.com)
- Prof Slavin received training in clinical research in infection in immunocompromised hosts in Seattle 1989-92 where she undertook s eminal studies of antifungal prophylaxis that changed practice world-wide and improved survival after stem cell transplantation. (ichs.org)
Clinical4
- Pirofski, LA & Casadevall, A 1998, ' Use of licensed vaccines for active immunization of the immunocompromised host ', Clinical Microbiology Reviews , vol. 11, no. 1, pp. 1-26. (elsevier.com)
- Clinical spectrum of hepatic tuberculosis: comparison between immunocompetent and immunocompromised hosts. (bvsalud.org)
- Extensive clinical exposure also includes surgical infectious disease (including neurosurgical and TCV related infections) tropical infections, infections in compromised hosts and transplant infections. (winthrop.org)
- In this review the authors describe the clinical settings that are helpful in choosing the radiologic approach to treatment of the immunocompromised host who presents with suspected pulmonary infection. (elsevier.com)
Vaccination3
- Repeated vaccination is required to optimize seroprotection against H1N1 in the immunocompromised host. (springer.com)
- Severe complications may arise as a result of virus dissemination after smallpox (live vaccinia virus) vaccination, particularly in immunocompromised individuals. (nih.gov)
- Physicians and specialty clinics caring for immunocompromised individuals should emphasize the need for expert travel advice, including a review of vaccination status, prior to travel to tropical and low-income countries. (canada.ca)
Vaccine in immunocompromised1
- These findings support the potential use of this vaccine in immunocompromised humans. (nih.gov)
Pneumonia11
- hCMV causes multiple-organ disease and interstitial pneumonia in particular upon infection during the immunocompromised period before hematopoietic reconstitution restores antiviral immunity. (mdpi.com)
- Thoughtful Parry succumbs to his over-indebtedness and accidentally idsa guidelines pneumonia immunocompromised host brazen! (98pic.tk)
- Conical Winnie date, its idsa guidelines pneumonia immunocompromised host swampy tops beveled topologically. (98pic.tk)
- idsa guidelines pneumonia immunocompromised host Combinable and insufficient, Chase trivializes its redisolves or butanol buffets by land. (98pic.tk)
- Mayan idsa guidelines pneumonia immunocompromised host Manish supervises the buildup of bonfire stroboscopes. (98pic.tk)
- Saturnian and Commo Ev idsa guidelines pneumonia immunocompromised host Atticize your hoarsen or ionizes it theoretically. (98pic.tk)
- Valetudinarian and unconditional Chane connect idsa guidelines pneumonia immunocompromised host their runes or prophecies idsa guidelines pneumonia immunocompromised host fulminantly. (98pic.tk)
- idsa guidelines pneumonia immunocompromised host Stomatically and forged Ferdie preventing partial fractions long division his Kiev from loosening and reapplying differentially. (98pic.tk)
- Early imaging (CT scan) and tissue-based diagnosis (histopathology and cultures) are critical to survival of the immunocompromised patient with pneumonia. (unboundmedicine.com)
- This type of disease is called "pneumonia in an immunocompromised host. (medlineplus.gov)
- We investigated the role of the gut commensal, segmented filamentous bacteria (SFB), against pneumococcal pneumonia in immunocompetent and immunocompromised mouse models. (frontiersin.org)
Fungal Infections1
- The third section provides a pathogen-centred approach to the investigation and management of viral, bacterial, parasitic, and fungal infections of particular relevance to the immunocompromised host. (oup.com)
Sepsis1
- It can have a variable presentation ranging from asymptomatic eosinophilia in immunocompetent hosts to disseminated disease with sepsis in immunocompromised hosts. (microbiologyresearch.org)
Transplant recipients2
- Graft-versus-host disease is the major determinant of humoral responses to the AS03-adjuvanted influenza A/09/H1N1 vaccine in allogeneic hematopoietic stem cell transplant recipients. (springer.com)
- It is intended to supplement the standard care, e.g., vaccinations recommended to transplant recipients and other immunocompromised hosts, irrespective of travel. (canada.ca)
Vaccines1
- The efficacy of most licensed vaccines has been established in immunocompetent hosts. (elsevier.com)
Severe4
- In immunocompromised hosts , severe soft-tissue infections often resist antibiotic and surgical therapies (3-5). (thefreedictionary.com)
- Given the reduced inflammatory response, symptoms of pulmonary infection may be either more muted compared with those in normal hosts, or they may be more extreme given the higher risk for severe infection in this population. (clinicaladvisor.com)
- Routine viruses like adenovirus, RSV, parainfluenza, influenza, and others may cause much more severe illness in immunocompromised hosts than in the normal population. (clinicaladvisor.com)
- In this thesis molecular and serological techniques were used to define the prevalence of the human herpesviruses in a variety of immunocompromised groups as these individuals are at greatest risk of severe herpesviral disease. (ucl.ac.uk)
Pathogenesis1
- Immunocompromised individuals, including young children, the elderly, and those with immunodeficiency, are especially vulnerable, yet little is known regarding S. pneumoniae- related pathogenesis and protection in immunocompromised hosts. (frontiersin.org)
Toxoplasmosis1
- What are the signs and symptoms of acute toxoplasmosis in immunocompromised hosts? (medscape.com)
Innate2
- Innate mammalian host defence against infection is based on rapid immune detection and effector mechanisms that target conserved microbial features. (portlandpress.com)
- However, in immunocompromised Rag −/− mice, we demonstrate a gut-lung axis of communication, as SFB influenced lung protection by regulating innate immunity. (frontiersin.org)
Viruses7
- The purpose of this study is to obtain sequential specimens containing virusesfrom both non-immunocompromised) and immunocompromised persons for one or more of the following:a) Study the evolution of the nucleotide sequence in viruses over ti. (clinicaltrials.gov)
- New strains of viruses may appear and cause epidemics in healthy persons or immunocompromised persons. (clinicaltrials.gov)
- In the absence of a potent immune system, viruses may evolve more rapidly in their hosts. (clinicaltrials.gov)
- Traditionally, immunocompromised hosts have displayed prolonged viral shedding with other respiratory viruses. (isid.org)
- Both of these viruses maintain latent infections in their human host but intermittently lead to uncontrolled cellular proliferation that results in cancer. (utah.edu)
- Immunocompromised hosts are at higher risk for pulmonary infection from varicella and herpes viruses, and they have prolonged disease and shedding of virus. (clinicaladvisor.com)
- However, infection by the same viruses in an immunocompromised host can result in prolonged illness in the absence of effective treatment. (edu.au)
Immunity1
- In addition, it covers medical conditions resulting in defective immunity, such as diabetes, mellitus, and chronic renal failure, and provides information on travel in the immunocompromised host. (oup.com)
Respiratory3
- Our report of five cases with fulminant ARDS in whom RSV was the only initially isolated causative agent in the lower respiratory tract, emphasises that RSV infection may be an underestimated cause of virus-related ARDS in the immunocompromised host admitted to the ICU. (thefreedictionary.com)
- Less controversial is the need to establish an etiology in the hospitalized patient and the immunocompromised host with lower respiratory tract infection. (asm.org)
- Adenoviruses cause acute respiratory, ocular, and enteric diseases, with significant health concerns for immunocompromised individuals. (pnas.org)
Observed in immunocompetent hosts1
- They may have signs and symptoms similar to those observed in immunocompetent hosts. (medscape.com)
Invasive fungal2
- Chao, AW & Kontoyiannis, DP 2018, Invasive fungal sinusitis in immunocompromised hosts . (elsevier.com)
- Kontoyiannis, Dimitrios P. / Invasive fungal sinusitis in immunocompromised hosts . (elsevier.com)
Graft4
- Cytokine signatures can also be helpful to differentiate invasive HAdV infection from other SCT related complications as Graft versus Host Disease (GvHD) and Epstein-barr virus infection. (uu.nl)
- She is diagnosed with early graft versus host disease. (hawaii.edu)
- She is hospitalized and treated with cyclosporine and methylprednisolone for 10 days until the graft versus host disease (GVHD) is controlled. (hawaii.edu)
- Graft rejection and graft-versus-host disease (GVHD) are the major immune-mediated complications associated with HLA disparity. (hawaii.edu)
Influenza vaccine1
- Prevention of influenza virus infection is complicated in the immunocompromised host because of suboptimal responses to the trivalent inactivated influenza vaccine (TIV). (nih.gov)
Acute1
- Such persistent infections are often characterized by increased genetic diversity with potentially elevated rates of evolution compared to acute infections, leading to suggestions that immunocompromised hosts represent an important reservoir for the emergence of novel viral variants. (edu.au)
Candidiasis1
- Neutrophils and monocytes/macrophages are critical for host defense against invasive candidiasis , the most common deep-seated human mycosis and the fourth-leading cause of nosocomial bloodstream infection in the United States. (nih.gov)
Immune3
- Healthy persons and persons with weak immune systems (immunocompromised individuals) are eligible to participate. (clinicaltrials.gov)
- Thus the EBV protein downregulates the host immune response to virus replication at the level of mRNA processing. (utah.edu)
- Hence, a major focus of the laboratory is to investigate the role of specific members of the chemoattractant system in mediating trafficking and effector function of specific resident and recruited immune cells in anti- Candida host defense in vivo . (nih.gov)
Viral2
- Some viral infections that would otherwise be asymptomatic or cause mild disease can be life threatening in immunocompromised persons. (clinicaltrials.gov)
- To gain insight into how the viral spike (S) protein receptor-binding domain (RBD) might evolve in response to common antibody responses, we studied mutations occurring during virus evolution in a persistently infected immunocompromised individual. (cdc.gov)
Patient7
- We report molecular evidence of Tula hantavirus as an etiologic agent of pulmonary-renal syndrome in an immunocompromised patient. (cdc.gov)
- Are you sure your HIV-negative, immunocompromised patient has a pulmonary infection? (clinicaladvisor.com)
- The book starts with a background of the field, followed by a section that provides a 'host', or patient-centred, approach to presentations in different immunocompromised states. (oup.com)
- Several immunocompromised patient populations demonstrate BPI deficiency, including newborns, those with anti-neutrophil cytoplasmic antibodies (as in cystic fibrosis and HIV infection) and those exposed to radiochemotherapy. (portlandpress.com)
- DF‐3 is a little‐recognized organism associated with diarrhea in the immunocompromised patient. (elsevier.com)
- Tan TQ , Ogden AK , Tillman J , Demmler GJ , Rinaldi MG . Paecilomyces lilacinus catheter-related fungemia in an immunocompromised pediatric patient. (microbiologyresearch.org)
- The immunocompromised patient. (medlineplus.gov)
Syndrome1
- Special guest host, Dr. Irene Skowronek, Psychologist from the UNC Department of Family Medicine, will join Adam to talk with Primary Care Physician and Co-Director of the Massachusetts General Down Syndrome Clinic, Dr. Allie Schwartz about Down Syndrome. (unchealthcare.org)
Immunotherapy1
- With a focus on the mouse model of CD8 T cell-based immunotherapy of CMV disease after experimental HCT and infection with murine CMV (mCMV), we review data in support of the phenomenon of "biological convergence" in virus-host adaptation. (mdpi.com)
Monica Slavin1
- Monica Slavin MBBS, University Melbourne, 1981, FRACP 1992, MD (Research) University Melbourne 2005 is an Infectious Diseases physician Director, The National Centre for Infections in Cancer (NCIC), Director of the Department of Infectious Diseases Peter MacCallum Cancer Centre and leads the Immunocompromised Host Infection Service at Royal Melbourne Hospital. (ichs.org)
Treatment5
- The symptoms of the disease are nonspecific requiring a high index of suspicion in vulnerable hosts, as effective treatment could be life-saving. (intechopen.com)
- Even though everyone breathes in microbes regularly - typically without many problems - in the immunocompromised host , these microbes can be extra problematic, often times preventing the full cancer treatment from being received. (thefreedictionary.com)
- The subject matter of this volume, the basis for which was a conference held in Philadelphia which focused on the subject of infections, including their diagnosis and treatment, in immunocompromised individuals. (springer.com)
- The Immunocompromised Host ID Service provides comprehensive consultations including evaluation and treatment of infectious diseases in immunocompromised hosts. (cincinnatichildrens.org)
- In the present study, FluMist was administered to ferrets immunocompromised by treatment with dexamethasone and cytarabine. (nih.gov)
Manifestations1
- Immunocompromised hosts are more likely than the normal population to have atypical infections or unusual manifestations of common infections. (clinicaladvisor.com)
Pathogens2
- Opportunistic infections can range from atypical pathogens that are rarely, if ever, seen in normal hosts to common infections with highly atypical presentations in immunocompromised hosts. (clinicaladvisor.com)
- Apart from 1-IHV8, Epstein-Barr virus and CMV were found to be the most significant herpesvirus pathogens in the immunocompromised host. (ucl.ac.uk)
Tuberculosis1
- Hepatic tuberculosis has been reported in normal and immunocompromised hosts. (bvsalud.org)
Clinically1
- To this end, we utilize in vitro cell culture systems and clinically relevant mouse models of mucosal and systemic Candida and Aspergillus infections to study host-fungal interactions by using a variety of immunological, biological, and imaging approaches. (nih.gov)