AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesNamed GroupsHealth Care
Hypothermia, InducedHypothermiaRewarmingBody TemperatureHypoxia-Ischemia, BrainHeart ArrestBody Temperature RegulationCirculatory Arrest, Deep Hypothermia InducedAsphyxia NeonatorumShiveringCardiopulmonary ResuscitationComaCold TemperatureHeart Arrest, InducedBrain InjuriesTime FactorsBrain IschemiaOut-of-Hospital Cardiac ArrestHeatingCardiopulmonary BypassHypoxia, BrainExtracorporeal CirculationResuscitationBrainAsphyxiaSkin TemperatureTreatment OutcomeRats, Sprague-DawleyDisease Models, AnimalIntracranial PressureIntraoperative ComplicationsInfant, NewbornBuspironeElectroencephalographyHyperthermia, InducedGastric HypothermiaTemperatureNeuroprotective AgentsPentobarbitalPargylineCerebrovascular CirculationMeperidineIntraoperative CareVentricular FibrillationNear DrowningRats, WistarAnesthesiaFeverMyxedemaYawning
Hypothermia, Induced
Abnormally low BODY TEMPERATURE that is intentionally induced in warm-blooded animals by artificial means. In humans, mild or moderate hypothermia has been used to reduce tissue damages, particularly after cardiac or spinal cord injuries and during subsequent surgeries.
Hypothermia
Lower than normal body temperature, especially in warm-blooded animals.
Rewarming
Application of heat to correct hypothermia, accidental or induced.
Body Temperature
The measure of the level of heat of a human or animal.
Hypoxia-Ischemia, Brain
A disorder characterized by a reduction of oxygen in the blood combined with reduced blood flow (ISCHEMIA) to the brain from a localized obstruction of a cerebral artery or from systemic hypoperfusion. Prolonged hypoxia-ischemia is associated with ISCHEMIC ATTACK, TRANSIENT; BRAIN INFARCTION; BRAIN EDEMA; COMA; and other conditions.
Heart Arrest
Cessation of heart beat or MYOCARDIAL CONTRACTION. If it is treated within a few minutes, heart arrest can be reversed in most cases to normal cardiac rhythm and effective circulation.
Body Temperature Regulation
The processes of heating and cooling that an organism uses to control its temperature.
Circulatory Arrest, Deep Hypothermia Induced
A technique to arrest the flow of blood by lowering BODY TEMPERATURE to about 20 degrees Centigrade, usually achieved by infusing chilled perfusate. The technique provides a bloodless surgical field for complex surgeries.
Asphyxia Neonatorum
Respiratory failure in the newborn. (Dorland, 27th ed)
Shivering
Involuntary contraction or twitching of the muscles. It is a physiologic method of heat production in man and other mammals.
Cardiopulmonary Resuscitation
The artificial substitution of heart and lung action as indicated for HEART ARREST resulting from electric shock, DROWNING, respiratory arrest, or other causes. The two major components of cardiopulmonary resuscitation are artificial ventilation (RESPIRATION, ARTIFICIAL) and closed-chest CARDIAC MASSAGE.
Coma
A profound state of unconsciousness associated with depressed cerebral activity from which the individual cannot be aroused. Coma generally occurs when there is dysfunction or injury involving both cerebral hemispheres or the brain stem RETICULAR FORMATION.
Cold Temperature
An absence of warmth or heat or a temperature notably below an accustomed norm.
Heart Arrest, Induced
A procedure to stop the contraction of MYOCARDIUM during HEART SURGERY. It is usually achieved with the use of chemicals (CARDIOPLEGIC SOLUTIONS) or cold temperature (such as chilled perfusate).
Brain Injuries
Acute and chronic (see also BRAIN INJURIES, CHRONIC) injuries to the brain, including the cerebral hemispheres, CEREBELLUM, and BRAIN STEM. Clinical manifestations depend on the nature of injury. Diffuse trauma to the brain is frequently associated with DIFFUSE AXONAL INJURY or COMA, POST-TRAUMATIC. Localized injuries may be associated with NEUROBEHAVIORAL MANIFESTATIONS; HEMIPARESIS, or other focal neurologic deficits.
Time Factors
Elements of limited time intervals, contributing to particular results or situations.
Brain Ischemia
Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.
Out-of-Hospital Cardiac Arrest
Occurrence of heart arrest in an individual when there is no immediate access to medical personnel or equipment.
Heating
The application of heat to raise the temperature of the environment, ambient or local, or the systems for accomplishing this effect. It is distinguished from HEAT, the physical property and principle of physics.
Cardiopulmonary Bypass
Diversion of the flow of blood from the entrance of the right atrium directly to the aorta (or femoral artery) via an oxygenator thus bypassing both the heart and lungs.
Hypoxia, Brain
A reduction in brain oxygen supply due to ANOXEMIA (a reduced amount of oxygen being carried in the blood by HEMOGLOBIN), or to a restriction of the blood supply to the brain, or both. Severe hypoxia is referred to as anoxia, and is a relatively common cause of injury to the central nervous system. Prolonged brain anoxia may lead to BRAIN DEATH or a PERSISTENT VEGETATIVE STATE. Histologically, this condition is characterized by neuronal loss which is most prominent in the HIPPOCAMPUS; GLOBUS PALLIDUS; CEREBELLUM; and inferior olives.
Extracorporeal Circulation
Diversion of blood flow through a circuit located outside the body but continuous with the bodily circulation.
Resuscitation
The restoration to life or consciousness of one apparently dead. (Dorland, 27th ed)
Brain
The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.
Asphyxia
A pathological condition caused by lack of oxygen, manifested in impending or actual cessation of life.
Skin Temperature
The TEMPERATURE at the outer surface of the body.
Treatment Outcome
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
Rats, Sprague-Dawley
A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.
Disease Models, Animal
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
Intracranial Pressure
Pressure within the cranial cavity. It is influenced by brain mass, the circulatory system, CSF dynamics, and skull rigidity.
Intraoperative Complications
Complications that affect patients during surgery. They may or may not be associated with the disease for which the surgery is done, or within the same surgical procedure.
Infant, Newborn
An infant during the first month after birth.
Buspirone
An anxiolytic agent and serotonin receptor agonist belonging to the azaspirodecanedione class of compounds. Its structure is unrelated to those of the BENZODIAZAPINES, but it has an efficacy comparable to DIAZEPAM.
Electroencephalography
Recording of electric currents developed in the brain by means of electrodes applied to the scalp, to the surface of the brain, or placed within the substance of the brain.
Hyperthermia, Induced
Abnormally high temperature intentionally induced in living things regionally or whole body. It is most often induced by radiation (heat waves, infra-red), ultrasound, or drugs.
Gastric Hypothermia
A method of lowering core BODY TEMPERATURE by filling the STOMACH with chilled fluids.
Temperature
The property of objects that determines the direction of heat flow when they are placed in direct thermal contact. The temperature is the energy of microscopic motions (vibrational and translational) of the particles of atoms.
Neuroprotective Agents
Drugs intended to prevent damage to the brain or spinal cord from ischemia, stroke, convulsions, or trauma. Some must be administered before the event, but others may be effective for some time after. They act by a variety of mechanisms, but often directly or indirectly minimize the damage produced by endogenous excitatory amino acids.
Pentobarbital
A short-acting barbiturate that is effective as a sedative and hypnotic (but not as an anti-anxiety) agent and is usually given orally. It is prescribed more frequently for sleep induction than for sedation but, like similar agents, may lose its effectiveness by the second week of continued administration. (From AMA Drug Evaluations Annual, 1994, p236)
Pargyline
A monoamine oxidase inhibitor with antihypertensive properties.
Cerebrovascular Circulation
The circulation of blood through the BLOOD VESSELS of the BRAIN.
Meperidine
A narcotic analgesic that can be used for the relief of most types of moderate to severe pain, including postoperative pain and the pain of labor. Prolonged use may lead to dependence of the morphine type; withdrawal symptoms appear more rapidly than with morphine and are of shorter duration.
Intraoperative Care
Patient care procedures performed during the operation that are ancillary to the actual surgery. It includes monitoring, fluid therapy, medication, transfusion, anesthesia, radiography, and laboratory tests.
Ventricular Fibrillation
A potentially lethal cardiac arrhythmia that is characterized by uncoordinated extremely rapid firing of electrical impulses (400-600/min) in HEART VENTRICLES. Such asynchronous ventricular quivering or fibrillation prevents any effective cardiac output and results in unconsciousness (SYNCOPE). It is one of the major electrocardiographic patterns seen with CARDIAC ARREST.
Near Drowning
Non-fatal immersion or submersion in water. The subject is resuscitable.
Rats, Wistar
A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain.
Anesthesia
A state characterized by loss of feeling or sensation. This depression of nerve function is usually the result of pharmacologic action and is induced to allow performance of surgery or other painful procedures.
Fever
An abnormal elevation of body temperature, usually as a result of a pathologic process.
Myxedema
A condition characterized by a dry, waxy type of swelling (EDEMA) with abnormal deposits of MUCOPOLYSACCHARIDES in the SKIN and other tissues. It is caused by a deficiency of THYROID HORMONES. The skin becomes puffy around the eyes and on the cheeks. The face is dull and expressionless with thickened nose and lips.
Yawning
An involuntary deep INHALATION with the MOUTH open, often accompanied by the act of stretching.

L-[1-11C]-tyrosine PET to evaluate response to hyperthermic isolated limb perfusion for locally advanced soft-tissue sarcoma and skin cancer. (1/1261)

PET with L-[1-11C]-tyrosine (TYR) was investigated in patients undergoing hyperthermic isolated limb perfusion (HILP) with recombinant tumor necrosis factor alpha (rTNF-alpha) and melphalan for locally advanced soft-tissue sarcoma and skin cancer of the lower limb. METHODS: Seventeen patients (5 women, 12 men; age range 24-75 y; mean age 52 y) were studied. TYR PET studies were performed before HILP and 2 and 8 wk afterwards. The protein synthesis rates (PSRs) in nanomoles per milliliter per minute were calculated. After final PET studies, tumors were resected and pathologically examined. Patients with pathologically complete responses (pCR) showed no viable tumors after treatment. Those with pathologically partial responses (pPR) showed various amounts of viable tumors in the resected tumor specimens. RESULTS: Six patients (35%) showed a pCR and 11 patients (65%) showed a pPR. All tumors were depicted as hot spots on PET studies before HILP. The PSR in the pCR group at 2 and 8 wk after perfusion had decreased significantly (P < 0.05) in comparison to the PSR before HILP. A significant difference was found in PSR between the pCR and pPR groups at 2 and at 8 wk (P < 0.05). Median PSR in nonviable tumor tissue was 0.62 and ranged from 0.22 to 0.91. With a threshold PSR of 0.91, sensitivity and specificity of TYR PET were 82% and 100%, respectively. The predictive value of a PSR > 0.91 for having viable tumor after HILP was 100%, whereas the predictive value of a PSR < or = 0.91 for having nonviable tumor tissue after HILP was 75%. The 2 patients in the pPR groups with a PSR < 0.91 showed microscopic islets of tumor cells surrounded by extensive necrosis on pathological examination. CONCLUSION: Based on the calculated PSR after HILP, TYR PET gave a good indication of the pathological outcome. Inflammatory tissue after treatment did not interfere with viable tumor on the images, suggesting that it may be worthwhile to pursue TYR PET in other therapy evaluation settings.  (+info)

Hypothermic neuroprotection of peripheral nerve of rats from ischaemia-reperfusion injury. (2/1261)

Although there is much information on experimental ischaemic neuropathy, there are only scant data on neuroprotection. We evaluated the effectiveness of hypothermia in protecting peripheral nerve from ischaemia-reperfusion injury using the model of experimental nerve ischaemia. Forty-eight male Sprague-Dawley rats were divided into six groups. We used a ligation-reperfusion model of nerve ischaemia where each of the supplying arteries to the sciatic-tibial nerves of the right hind limb was ligated and the ligatures were released after a predetermined period of ischaemia. The right hind limbs of one group (24 rats) were made ischaemic for 5 h and those of the other group (24 rats) for 3 h. Each group was further divided into three and the limbs were maintained at 37 degrees C (36 degrees C for 5 h of ischaemia) in one, 32 degrees C in the second and 28 degrees C in the third of these groups for the final 2 h of the ischaemic period and an additional 2 h of the reperfusion period. A behavioural score was recorded and nerve electrophysiology of motor and sensory nerves was undertaken 1 week after surgical procedures. At that time, entire sciatic-tibial nerves were harvested and fixed in situ. Four portions of each nerve were examined: proximal sciatic nerve, distal sciatic nerve, mid-tibial nerve and distal tibial nerve. To determine the degree of fibre degeneration, each section was studied by light microscopy, and we estimated an oedema index and a fibre degeneration index. The groups treated at 36-37 degrees C underwent marked fibre degeneration, associated with a reduction in action potential and impairment in behavioural score. The groups treated at 28 degrees C (for both 3 and 5 h) showed significantly less (P < 0.01; ANOVA, Bonferoni post hoc test) reperfusion injury for all indices (behavioural score, electrophysiology and neuropathology), and the groups treated at 32 degrees C had scores intermediate between the groups treated at 36-37 degrees C and 28 degrees C. Our results showed that cooling the limbs dramatically protects the peripheral nerve from ischaemia-reperfusion injury.  (+info)

Myocardial temperature reduction attenuates necrosis after prolonged ischemia in rabbits. (3/1261)

OBJECTIVE: Previously we observed that a large reduction in infarct size was attained by cooling the risk region of the heart, either before or early after the onset of a 30-min coronary artery occlusion. While this is a standard duration of ischemia used in the rabbit model of infarction, it may not reflect the situation of patients who are reperfused late. The effects of regional hypothermia with a longer duration of ischemia, and when the intervention is applied later, are unknown. This study tests the hypothesis that a local reduction in cardiac temperature protects myocardium during prolonged ischemia (2 h) even if begun well after coronary artery occlusion. METHODS: Anesthetized rabbits received 2 h of coronary artery occlusion and 3 h of reperfusion. Rabbits were randomly assigned to a treated group: topical myocardial cooling starting 30 min after coronary occlusion (n = 14), or control group, no intervention (n = 12). Myocardial temperature in the risk zone, hemodynamics and regional myocardial blood flow were measured. RESULTS: Ischemic zone temperature was similar in both groups at 30 min post occlusion, but the cooling maneuver produced a reduction in temperature in the risk region of the treated group such that myocardial temperature was reduced an average of 10 degrees C between 30 and 60 min of coronary artery occlusion. Myocardial temperature in the control group remained within 0.3 degree C of baseline during coronary artery occlusion and into reperfusion. Core temperatures were similar in both groups. Hemodynamic parameters and collateral blood flow during occlusion were also equivalent in both groups. After 120 min of coronary occlusion, necrosis in the control group comprised 72 +/- 3% of the ischemic risk region. However, in cooled hearts, infarct size, expressed as a fraction of the risk region was significantly lower. Infarct size in this group averaged 59 +/- 3% of the risk region (p < 0.004 vs. controls), and thus cooling resulted in a salvage of approximately 18% of the risk region. CONCLUSION: These results show that reducing myocardial temperature protects ischemic myocardium during a long duration of ischemia even if initiated after coronary artery occlusion.  (+info)

RVLM and raphe differentially regulate sympathetic outflows to splanchnic and brown adipose tissue. (4/1261)

To determine whether neurons in the rostral raphe pallidus (RPa) specifically control the sympathetic nerve activity to brown adipose tissue (BAT SNA), thereby regulating adipocyte metabolism and BAT thermogenesis, the responses in BAT SNA to disinhibition of RPa neurons and to disinhibition of neurons in the vasomotor region of the rostral ventrolateral medulla (RVLM) were compared with those in splanchnic (Spl) SNA, which primarily regulates visceral vasoconstriction. In urethan-chloralose-anesthetized ventilated rats, both acute hypothermia and microinjection of bicuculline into RPa produced significantly larger increases in BAT SNA (542 and 1,949% of control) than in Spl SNA (19 and 24% of control). The enhanced burst discharge in BAT SNA was not coherent with that in Spl SNA or with the arterial pressure (AP) at any frequency except the central respiratory frequency. Microinjections of bicuculline into RVLM evoked increases in Spl SNA (86% of control) and AP (32 mmHg), but reduced BAT SNA to low, normothermic levels. Microinjections of muscimol into RVLM reduced Spl SNA (-82% of control) and AP (-59 mmHg), but did not prevent the increase in BAT SNA after disinhibition of RPa neurons. These results indicate that the neural networks generating BAT SNA in response to disinhibition of RPa neurons are independent of those generating basal Spl SNA and support a model in which sympathetic outflow to tissues involved in thermoregulation and metabolism is regulated by central pathways, including neurons in RPa, that are distinct from those involved in the sympathetic control of the cardiovascular system.  (+info)

A comparative study between hypothermic and normothermic cardiopulmonary bypass in open heart surgery in dogs--effects on systemic hemodynamics. (5/1261)

Open heart surgery was performed on two groups of dogs under extracorporeal circulation with or without hypothermia to investigate hemodynamic changes during extracorporeal circulation. During hypothermic cardiopulmonary bypass (CPB), arterial O2 tension and postoperative blood pressure were favorably maintained, indicating that hypothermic extracorporeal circulation can be performed for a long period of time. On the other hand, during normothermic CPB, the average surgical duration was significantly shorter, and marked shifts in the concentrations of various enzymes were suppressed. However, due to reductions in arterial O2 tension, the length of cardiac arrest time was restricted, demonstrating that this method is suitable for performing extracorporeal circulation for CPB of relatively short duration. If circulation circuitry can be improved, such as through the development of a surpassing oxygenator, normothermic CPB would incur less stress on the body, thus making it preferential to hypothermic CPB in most cases.  (+info)

Peroxisome proliferator-activated receptor alpha mediates the adaptive response to fasting. (6/1261)

Prolonged deprivation of food induces dramatic changes in mammalian metabolism, including the release of large amounts of fatty acids from the adipose tissue, followed by their oxidation in the liver. The nuclear receptor known as peroxisome proliferator-activated receptor alpha (PPARalpha) was found to play a role in regulating mitochondrial and peroxisomal fatty acid oxidation, suggesting that PPARalpha may be involved in the transcriptional response to fasting. To investigate this possibility, PPARalpha-null mice were subjected to a high fat diet or to fasting, and their responses were compared with those of wild-type mice. PPARalpha-null mice chronically fed a high fat diet showed a massive accumulation of lipid in their livers. A similar phenotype was noted in PPARalpha-null mice fasted for 24 hours, who also displayed severe hypoglycemia, hypoketonemia, hypothermia, and elevated plasma free fatty acid levels, indicating a dramatic inhibition of fatty acid uptake and oxidation. It is shown that to accommodate the increased requirement for hepatic fatty acid oxidation, PPARalpha mRNA is induced during fasting in wild-type mice. The data indicate that PPARalpha plays a pivotal role in the management of energy stores during fasting. By modulating gene expression, PPARalpha stimulates hepatic fatty acid oxidation to supply substrates that can be metabolized by other tissues.  (+info)

Ischemic preconditioning and myocardial hypothermia in rabbits with prolonged coronary artery occlusion. (7/1261)

This study tests whether combining regional hypothermia and ischemic preconditioning (IP) provides greater myocardial protection during prolonged coronary artery occlusion (CAO) than either intervention alone, and whether increasing the duration of IP from 5 to 7 min extends the window of protection to include a 2-h CAO. Anesthetized rabbits were randomized to four groups (n = 8 rabbits/group): control (C), hypothermia alone (H), IP alone for two 7-min episodes (IP7), and IP plus hypothermia (H + IP7). To compare differences in IP for 5 versus 7 min, additional rabbits (n = 6) received one 5-min episode of ischemia (IP5). All rabbits got 2 h of CAO and 3 h of reperfusion. In comparison with the infarct size in the control group (72 +/- 4% of the risk zone), infarct size was significantly reduced in H (50 +/- 7%), IP7 (49 +/- 5%), and H + IP7 (42 +/- 6%) (all P < 0.05 vs. control group). IP5 failed to confer protection (67 +/- 5% of the risk zone). Therefore, IP can protect against a 2-h CAO if the IP regimen is increased from 5 to 7 min. The combination therapy significantly improved regional myocardial blood flow in the previously ischemic region to a greater extent than either treatment alone.  (+info)

Effect of mild hypothermia on the changes of cerebral blood flow, brain blood barrier and neuronal injuries following reperfusion of focal cerebral ischemia in rats. (8/1261)

OBJECTIVE: To compare the effects of mild hypothermia induced in different time courses on rats subjected to 3 hours (h) of ischemia followed by 3 h or 72 h of reperfusion. METHODS: Eighty male Sprague-Dawley rats were divided into three mild hypothermic (MHT, 32 +/- 0.2 degrees C) groups, including intra-ischemia (MHTi), intra-reperfusion (MHTr), and intra-ischemia/reperfusion (MHTi + r) group, and one normothermic group (NT, 37 +/- 0.2 degrees C) as the control. Reversible focal ischemia was carried out in rats with suture model. The cortical blood flow was measured during 3 h of ischemia followed by 3 h of reperfusion. The permeability of brain blood barrier (BBB) was estimated after 3 h of reperfusion. The infarct volume was measured at 72 h after reperfusion to determine the effects of MHT. RESULTS: The acute post-ischemic hyperperfusion and delayed hypoperfusion in ischemic perifocal region and sustained hypoperfusion in ischemic core were inhibited in MHTi + r and MHTi rats (P < 0.05). MHTi + r protection on post-ischemic progressive hypoperfusion in the perifocal region was more effective than that of MHTi (P < 0.05). The BBB disruption and the infarct volume were significantly reduced in both MHTi and MHTi + r groups (P < 0.05), especially in the MHTi + r rats. CONCLUSIONS: This study demonstrates that MHTi + r has more substantial protective effects on reducing ischemia/reperfusion injury than MHTi. It may inhibit post-ischemic hyperperfusion and delayed or sustained hypoperfusion in ischemic perifocal regions, and reduce brain blood barrier disruption in the cortex region.  (+info)

Effects of mild hypothermia therapy on the levels of glutathione in rabbit blood and cerebrospinal fluid after cardiopulmonary...Effects of mild hypothermia therapy on the levels of glutathione in rabbit blood and cerebrospinal fluid after cardiopulmonary...
Objective(s): The aim of this study wasto investigate the effects of mild hypothermia therapy on oxidative stress injury of rabbit brain tissue after cardiopulmonary resuscitation (CPR). Materials and Methods: Rabbit models of cardiac arrest were established. After the restoration of spontaneous circulation, 50 rabbits were randomly divided into normothermia and hypothermia groups. The following five time points were selected: before CPR, immediately after CPR, 2 hr after CPR (hypothermia group reached the target temperature), 14 hr after CPR (hypothermia group before rewarming), and 24 hr after CPR (hypothermia group recovered to normal temperature). Glutathione (GSH) concentrations in both the blood and cerebrospinal fluid of the normothermia and hypothermia groups were measured. Results:At 2, 14, and 24 hr after CPR, the GSH concentrations in both the blood and cerebrospinal fluid were significantly higher in the hypothermia group than in the nomorthermia group. Conclusion:Mild hypothermia therapy
https://ijbms.mums.ac.ir/article_4024.html
Treatment of Hyperthermia, Hypothermia Symptoms, Hypothermia Definition, Causes, Risk Factors, Symptoms, Diagnosis & Treatment,...
Treatment of Hypothermia is abnormally low body temperature. It is a dangerous condition caused when your body loses more heat than it can produce. It requires immediate medical attention, Hyperthermia, Hypothermia Symptoms, Hypothermia Causes, Hypothermia Definition, Hypothermia Treatment, Hypothermia Diagnosis, Hypothermia Risk Factors, Hypothermia Syndrome, Hypothermia Prevention, Hypothermia Signs, Hypothermia Therapy, Acute Hypothermia, Chronic Hypothermia, Effects Of Hypothermia, Hypothermia Emedicine, Hypothermia Surgery
http://www.knowyourdisease.com/treatment-of-hypothermia.html
Who benefits most from mild therapeutic hypothermia in coronary intervention era? A retrospective and propensity-matched study ...Who benefits most from mild therapeutic hypothermia in coronary intervention era? A retrospective and propensity-matched study ...
The aim of the present study was to investigate the impact of the time interval from collapse to return of spontaneous circulation (CPA-ROSC) in cardiac arrest patients and the types of patients who will benefit from therapeutic hypothermia. Four hundred witnessed adult comatose survivors of out-of-hospital cardiac arrest of cardiac etiology were enrolled in the study. The favorable neurological outcome was defined as category 1 or 2 on the five-point Pittsburgh cerebral performance scale at the time of hospital discharge. A matching process based on the propensity score was performed to equalize potential prognostic factors in the hypothermia and normothermia groups, and to formulate a balanced 1:1 matched cohort study. The rate of favorable neurological outcome was higher (P | 0.05) in the hypothermia group (n = 110) than in the normothermia group in patients with CPA-ROSC of 15 to 20 minutes (64% vs. 17%), 20 to 25 minutes (70% vs. 8%), 25 to 30 minutes (50% vs. 7%), 35 to 40 minutes (27% vs. 0%) and
https://ccforum.biomedcentral.com/articles/10.1186/cc9225
Severe QTc prolongation under mild hypothermia treatment and incidence of arrhythmias after cardiac arrest-A prospective study...
BACKGROUND: Mild hypothermia treatment (32-34°C) in survivors after cardiac arrest (CA) is clearly recommended by the current guidelines. The effects of cooling procedure towards QT interval have not been evaluated so far outside of case series. In
http://www.biomedsearch.com/nih/Severe-QTc-prolongation-under-mild/21482009.html
Pilot Study For Hypothermia Treatment In Hyperammonemic Encephalopathy In Neonates And Very Young Infants - Full Text View -...Pilot Study For Hypothermia Treatment In Hyperammonemic Encephalopathy In Neonates And Very Young Infants - Full Text View -...
This is a pilot study which will test the safety and feasibility of hypothermia treatment as adjunct therapy to conventional treatment of hyperammonemic encephalopathy (HAE) in neonates versus conventional treatment (dialysis, nutritional therapy, and ammonia scavenging drugs) only. The endpoint of the pilot study will be reached when either 24 patients have been enrolled and no serious adverse events were observed, when no patient has been enrolled in 5 years, or when serious adverse events occur which are clearly linked to the use of hypothermia. These would be serious complications not seen in patients on conventional therapy (dialysis , nutritional therapy, ammonia scavenging drugs) for HAE ...
https://clinicaltrials.gov/ct2/show/NCT01624311?cond=%22Argininosuccinic+aciduria%22&rank=3
Study questions hypothermia treatment for card... ( Therapeutic hypothermia cooling the...)Study questions hypothermia treatment for card... ( Therapeutic hypothermia cooling the...)
Health, ...Therapeutic hypothermia cooling the body and brain down to 33C is th... Our results show that it is just as effective both for survival and ...,Study,questions,hypothermia,treatment,for,cardiac,arrest,medicine,medical news today,latest medical news,medical newsletters,current medical news,latest medicine news
http://www.bio-medicine.org/medicine-news-1/Study-questions-hypothermia-treatment-for-cardiac-arrest-121141-1/
Whole Body Hypothermia SystemWhole Body Hypothermia System
Whole Body Hypothermia System,This revolutionary system combines the CSZ Head Wrap and Patient Vest for a non-invasive whole body hypothermia system. This method of cooling the patient allows for early treatment that is fast, cost-effective and safe.,medicine,medical supply,medical supplies,medical product
http://bio-medicine.org/medicine-products/Whole-Body-Hypothermia-System-19217-1/
Effects of Regional and Whole-body Hypothermic Treatment before and after Median Nerve Injury on Neuropathic Pain and Glial...Effects of Regional and Whole-body Hypothermic Treatment before and after Median Nerve Injury on Neuropathic Pain and Glial...
Fig. 9. Histograms showing the proinflammatory cytokine expression in the ipsilateral cuneate nucleus (CN) on day 7 after chronic constriction injury (CCI) in rats treated with regional or whole-body hypothermia. A significant decrease in levels of tumor necrosis factor (TNF)-α (A ) and interleukin (IL)-1β (B ) was observed after applying regional hypothermia (P , 0.05, by two-way ANOVA). In rats pretreated with mild or deep regional hypothermia, there was a significant decrease in TNF-α (A ) and IL-1β (B ) levels compared with those pretreated with regional normothermia (*P , 0.05, by Tukey test). Similarly, in the 5 h postinjury group, TNF-α (A ) and IL-1β (B ) levels in the CN were significantly decreased in CCI rats that received mild or deep regional hypothermia compared with those that received regional normothermia (*P , 0.05, by Tukey test). In addition, deep regional hypothermia administered preinjury and 5 h postinjury more effectively suppressed TNF-α (A ) and IL-1β (B ) ...
http://anesthesiology.pubs.asahq.org/article.aspx?articleid=1933892
Withdrawal Of Care May Occur Too Soon In Cardiac Arrest Patients Who Receive Hypothermia Treatment - RedorbitWithdrawal Of Care May Occur Too Soon In Cardiac Arrest Patients Who Receive Hypothermia Treatment - Redorbit
Patients often regain consciousness 3 days or more after arrest. Physicians may be making premature predictions about which patients are not likely to survive following cardiac arrest - and even withdrawing care -- before the window in which comatose patients who have received therapeutic hypothermia are most likely to wake up, according to two new studies from the Perelman School of Medicine at the University of Pennsylvania. The research helps to better define the proper timeframe and manner in which doctors may be able to predict which patients will regain consciousness after the use of therapeutic hypothermia, which preserves brain and other organ function following cardiac arrest.. Patients treated with hypothermia often dont regain consciousness until three or more days after their cardiac arrest, according Penn research that will present today at the American Heart Associations annual Scientific Sessions (Abstract #10778. But in a separate Penn study published online this week in ...
http://www.redorbit.com/news/health/1112422302/withdrawal-of-care-may-occur-too-soon-in-cardiac-arrest-patients-who-receive-hypothermia-treatment/
Enteral Feeding during therapeutic hypothermia, 978-3-659-61988-5, 3659619884 ,9783659619885 Di Marie-Louise...Enteral Feeding during therapeutic hypothermia, 978-3-659-61988-5, 3659619884 ,9783659619885 Di Marie-Louise...
Enteral Feeding during therapeutic hypothermia, 978-3-659-61988-5, The basic provision of nutrition in the critical care population has been associated with reduced length of stay and improved outcome. Often catabolic, these patients are at risk of malnutrition. Government bodies advise and expect those requiring mechanical ventilation during critical illness to be enterally fed wherever possible. Cardiac arrest victims treated with neuroprotective therapeutic hypothermia often encounter the postponement of enteral feed until normothermia is restored. This is due to a lack of research evidence surrounding the ability for a hypothermic patient to absorb feed formulas. This is the first known study that sought to identify what percentage of feed could be tolerated by cooled victims of cardiac arrest during three distinct phases of therapeutic hypothermia. This included 24 hours at target temperature (32-34°C), 24 hours rewarming to 36.5°C and 24 hours maintained at a core temperature below 37.5°C. A
https://www.morebooks.de/store/it/book/enteral-feeding-during-therapeutic-hypothermia/isbn/978-3-659-61988-5?currency=HKD
Asphyxiated neonates who received active therapeutic hypothermia during transport had higher rates of hypocapnia than controls<...
TY - JOUR. T1 - Asphyxiated neonates who received active therapeutic hypothermia during transport had higher rates of hypocapnia than controls. AU - Szakmar, Eniko. AU - Kovacs, Kata. AU - Meder, Unoke. AU - Bokodi, Geza. AU - Szell, Andras. AU - Somogyvari, Zsolt. AU - Szabo, Attila J.. AU - Szabó, M.. AU - Jermendy, Agnes. PY - 2018/1/1. Y1 - 2018/1/1. N2 - Aim: We investigated the association between active hypothermia and hypocapnia in neonates with moderate-to-severe hypoxic-ischaemic encephalopathy (HIE) transported after birth. Methods: This was a retrospective cohort study of neonates with HIE born between 2007 and 2011 and transported to Semmelweis University, Hungary, for hypothermia treatment before and after we introduced active cooling during transport in 2009. Of these, 71 received intensive care plus controlled active hypothermia during transport, while the 46 controls just received standard intensive care. Incident hypocapnia was defined as a partial pressure of carbon-dioxide ...
https://hungary.pure.elsevier.com/en/publications/asphyxiated-neonates-who-received-active-therapeutic-hypothermia-
Fever after rewarming: incidence of pyrexia in postcardiac arrest patients who have undergone mild therapeutic hypothermia |...Fever after rewarming: incidence of pyrexia in postcardiac arrest patients who have undergone mild therapeutic hypothermia |...
BACKGROUND: Induction of mild therapeutic hypothermia (TH; temperature 32-34°C) has become standard of care in many hospitals for comatose survivors of cardiac arrest. Pyrexia, or fever, is known to be detrimental in patients with neurologic injuries such as stroke or trauma. The incidence of pyrexia in the postrewarming phase of TH is unknown. We attempted to determine the incidence of fever after TH and hypothesized that those patients who were febrile after rewarming would have worse clinical outcomes than those who maintained normothermia in the postrewarming period.. METHODS: Retrospective data analysis of survivors of out-of-hospital cardiac arrest (OHCA) over a period of 29 months (December 2007 to April 2010).. INCLUSION CRITERIA: OHCA, age ,18, return of spontaneous circulation, and treatment with TH.. EXCLUSION CRITERIA: traumatic arrest and pregnancy. Data collected included age, sex, neurologic outcome, mortality, and whether the patient developed fever (temperature , 100.4°F, ...
https://read.qxmd.com/read/23783999/fever-after-rewarming-incidence-of-pyrexia-in-postcardiac-arrest-patients-who-have-undergone-mild-therapeutic-hypothermia
TIME Study: Therapeutic Hypothermia for Infants With Mild Encephalopathy - Tabular View - ClinicalTrials.govTIME Study: Therapeutic Hypothermia for Infants With Mild Encephalopathy - Tabular View - ClinicalTrials.gov
The TIME study is a multi-center randomized, controlled trial of Therapeutic Hypothermia (TH) (33.5°C ± 0.5° for 72 hours) versus normothermia using targeted temperature management, initiated within 6 hours after birth in term neonates with Mild Hypoxic-Ischemic Encephalopathy (HIE). Mild encephalopathy will be identified using the 6 component modified Sarnat exam as in the Neonatal Research Network of the National Institute of Child Health and Human Development trials of TH for moderate-severe encephalopathy and will be expanded to include features of mild encephalopathy. Eligible subjects must demonstrate ≥ 2 exam abnormalities (mild, moderate, severe) but without evidence of moderate-severe encephalopathy (≥ 3 moderate or severe features). The primary outcome is neurodevelopmental outcome at 12-14 months of age. Secondary outcomes include evaluating the safety profile of therapeutic hypothermia in patients with Mild HIE. Therapeutic hypothermia is well tolerated and did not demonstrate ...
https://clinicaltrials.gov/ct2/show/record/NCT04176471
Moderate hypothermia during cardiopulmonary bypass reduces myocardial cell damage and myocardial cell death related to cardiac...Moderate hypothermia during cardiopulmonary bypass reduces myocardial cell damage and myocardial cell death related to cardiac...
We showed in a previous experimental study that moderate hypothermia during CPB increases IL10 blood concentrations and blunts TNFα production (2). We demonstrate here that systemic moderate hypothermia leads to increased gene expression and synthesis of IL10 in the myocardium after CPB and that this is related to myocardial protection. Despite the short observational period of 6 h, which did not allow us to extrapolate the outcome of the animals investigated, a substantial clinical benefit could be noticed, wherein the need for inotropic support to maintain stable hemodynamics was less in animals that were in moderate hypothermia during surgery. This cardioprotective effect of moderate hypothermia related to anti-inflammatory cytokine balance shown here could justify its use in clinical practice, especially in patients with severe preoperative heart failure in whom pro-inflammatory cytokine synthesis in the myocardium is thought to contribute to myocardial dysfunction (4).. The mechanisms by ...
http://www.onlinejacc.org/content/38/4/1216
Absent SEP during therapeutic hypothermia did not reappear after re-warming in comatose patients following cardiac arrest<...
TY - JOUR. T1 - Absent SEP during therapeutic hypothermia did not reappear after re-warming in comatose patients following cardiac arrest. AU - Grippo, A.. AU - Carrai, R.. AU - Fossi, S.. AU - Cossu, C.. AU - Mazzeschi, E.. AU - Peris, A.. AU - Bonizzoli, M.. AU - Ciapetti, M.. AU - Gensini, G. F.. AU - Pinto, F.. AU - Amantini, A.. PY - 2013/4. Y1 - 2013/4. N2 - Background. Early prediction of neurological outcome for patients resuscitated from cardiac arrest (CA) is a challenging task. Therapeutic hypothermia (TH) has been shown to improve neurological outcome after CA. Two recent studies indicated that somatosensory evoked potentials (SEP) recorded during TH retains high prediction value for poor neurological outcome. It remains unclear whether TH can influence the recovery of bilaterally absent (BA) N20 after re-warming. The primary endpoint of the present study was to evaluate if patients with BA SEPs during TH can recover cortical responses after re-warming. The secondary endpoint was to ...
https://moh-it.pure.elsevier.com/en/publications/absent-sep-during-therapeutic-hypothermia-did-not-reappear-after-
PSRC - Local Mild Hypothermia (30-32°C) Is Effective In Protection Of Ex Vivo Human Skeletal Muscle From Hypoxia/reoxygenation...PSRC - Local Mild Hypothermia (30-32°C) Is Effective In Protection Of Ex Vivo Human Skeletal Muscle From Hypoxia/reoxygenation...
1Hospital for Sick Children, Toronto, ON, Canada, 2Toronto General Hospital, Toronto, ON, Canada. Introduction: In reconstructive surgery, skeletal muscle may endure protracted ischemia before reperfusion which may lead to significant ischemia/reperfusion injury. Other investigators reported that low local hypothermia (local cooling at 4-10°C) significantly reduced ischemia/reperfusion injury in skeletal muscle of different species of laboratory animals. However, this range of severe low local hypothermia is known to induce capillary damage. More recently, other investigators reported that low local mild hypothermia at 32-34°C significantly reduced ischemia/reperfusion injury in rabbit rectus femoris muscle in vivo. However, this infarct protective effect of low local hypothermia has not been tested in human skeletal muscle. The objective of this study was to use our established ex vivo human skeletal muscle culture model to study the efficacy of low local mild hypothermia (30-32°C) in ...
http://ps-rc.org/meeting/abstracts/2014/150.cgi
Abstract 48: Reduction of Histological Damage with Mild Therapeutic Hypothermia after Prolonged Cardiac Arrest | CirculationAbstract 48: Reduction of Histological Damage with Mild Therapeutic Hypothermia after Prolonged Cardiac Arrest | Circulation
Purpose: The aim of our study was to assess the effect of hypothermia on histological damage in 19 brain regions after prolonged cardiac arrest in pigs.. Methods: Pigs were anaesthetized and mechanically ventilated. After stabilisation of pulmonary artery temperature (Tpa) at 38.5±0.2 °C, ventricular fibrillation (VF) was induced and 10 min of untreated VF were followed by 8 min of cardiopulmonary resuscitation (mechanical chest compressions, two doses of vasopressin 0.4 IE/kg). At 8 min of CPR, up to 3 countershocks were delivered. Pigs that had return of spontaneous circulation (ROSC) were randomized to one of 2 groups (control, hypothermia). Pigs in the hypothermia group were cooled to Tpa 33.0±1.0 °C with a surface cooling device (LRS Thermosuit™) circulating ice water over most of the skin surface. Pigs in the control group were kept at 38.5±1.0 °C throughout the experiment. After 14 hours of hypothermia, pigs were rewarmed, weaned and brought to the stable. At day 9 of the ...
http://circ.ahajournals.org/content/116/Suppl_16/II_933.3
Abstract 2000: Rapid Brain Cooling During Cardiopulmonary Resuscitation Followed By Systemic Therapeutic Hypothermia Reduces...Abstract 2000: Rapid Brain Cooling During Cardiopulmonary Resuscitation Followed By Systemic Therapeutic Hypothermia Reduces...
Background: Therapeutic hypothermia has been known to reduce post-resuscitation neurological deficit and protect the cardiomyocyte from ischemia/reperfusion injury.. Hypothesis: Rapid brain cooling during CPR followed by systemic cooling reduces the severity of post-resuscitation myocardial dysfunction after prolonged ventricular fibrillation (VF). Methods: VF was induced in 16 domestic pigs and untreated for 10 minutes. CPR was then initiated for 5 minutes before defibrillation attempts. Coincident with starting CPR, the hypothermia group (n=8) was cooled by a Rhinochill device, which cooled the brain, followed by systemic hypothermia. The cooling was continued to achieve a target core temperature of 34°C.The body temperature of the control group was not intervened after VF was induced. Transthoracic echocardiography was performed before VF, hourly after return of spontaneous circulation (ROSC) for 4 hours, and at 96 hours.. Results: Both myocardial systolic (LVEF) and diastolic (isovolumic ...
http://circ.ahajournals.org/content/116/Suppl_16/II_432.3
EFFECT OF POST-ISCHEMIC MILD HYPOTHERMIA ON THE LEVELS OF IMPORTANT CYTOKINES IN THE ENDOTHELIN-1 RAT MODEL FOR FOCAL CEREBRAL...EFFECT OF POST-ISCHEMIC MILD HYPOTHERMIA ON THE LEVELS OF IMPORTANT CYTOKINES IN THE ENDOTHELIN-1 RAT MODEL FOR FOCAL CEREBRAL...
Dive into the research topics of EFFECT OF POST-ISCHEMIC MILD HYPOTHERMIA ON THE LEVELS OF IMPORTANT CYTOKINES IN THE ENDOTHELIN-1 RAT MODEL FOR FOCAL CEREBRAL ISCHEMIA. Together they form a unique fingerprint. ...
https://researchportal.vub.be/en/publications/effect-of-post-ischemic-mild-hypothermia-on-the-levels-of-importa-2/fingerprints/
Mild hypothermia delays the development of stone heart from untreated sustained ventricular fibrillation - a cardiovascular...Mild hypothermia delays the development of stone heart from untreated sustained ventricular fibrillation - a cardiovascular...
Stone heart resulting from ischemic contracture of the myocardium, precludes successful resuscitation from ventricular fibrillation (VF). We hypothesized that mild hypothermia might slow the progression to stone heart. Fourteen swine (27 ± 1 kg) were randomized to normothermia (group I; n = 6) or hypothermia groups (group II; n = 8). Mild hypothermia (34 ± 2°C) was induced with ice packs prior to VF induction. The LV and right ventricular (RV) cross-sectional areas were followed by cardiovascular magnetic resonance until the development of stone heart. A commercial 1.5T GE Signa NV-CV/i scanner was used. Complete anatomic coverage of the heart was acquired using a steady-state free precession (SSFP) pulse sequence gated at baseline prior to VF onset. Un-gated SSFP images were obtained serially after VF induction. The ventricular endocardium was manually traced and LV and RV volumes were calculated at each time point. In group I, the LV was dilated compared to baseline at 5 minutes after VF and this
https://jcmr-online.biomedcentral.com/articles/10.1186/1532-429X-13-17
Outcomes in the Era of Therapeutic Hypothermia | American Academy of PediatricsOutcomes in the Era of Therapeutic Hypothermia | American Academy of Pediatrics
Encephalopathy in the late preterm and term infant is an important clinical condition because it can be associated with death or poor neurodevelopment in early childhood. Stages of encephalopathy (mild, moderate, and severe) soon after birth have value in predicting outcome during early infancy and even at early school-age. Prompt recognition after birth of the subset of infants in whom encephalopathy is associated with hypoxia-ischemia (hypoxic-ischemic encephalopathy [HIE]) is critical because the outcome is potentially modifiable with therapeutic hypothermia. A series of large randomized clinical trials have provided better estimates of the outcomes of moderate and severe HIE compared with the era before the hypothermia trials. Therapeutic hypothermia reduces the composite outcome of death or a major disability at 18 months to 2 years of age among term infants who have moderate or severe encephalopathy. School-age follow-up of a limited number of infants from these trials indicates that death ...
https://neoreviews.aappublications.org/content/15/9/e386
Normal saline versus colloid solutions for induction of hypothermia: the effect of specific heat capacity on cooling | Critical...Normal saline versus colloid solutions for induction of hypothermia: the effect of specific heat capacity on cooling | Critical...
The prevention of ischemic injury to preserve both end-organ function and improve neurological recovery by the implementation of therapeutic hypothermia has been well established in the literature. However, not only the means by which body temperature is cooled but also the rate by which target temperature is attained remains an area of continued interest and research. The induction of therapeutic hypothermia to begin the process of body temperature lowering through the infusion of a cold solution intravenously into the body may be one variable that influences not only rapidity of cooling but also subsequent clinical outcome. In a recent issue of Critical Care, Skulec and colleagues compared the induction of therapeutic hypothermia by cold normal saline versus cold colloid solution containing hydroxyethyl starch in a porcine animal model of cardiac arrest, assessing both the rate of temperature change and target temperature achieved, in addition to changes in intracranial pressure.
https://ccforum.biomedcentral.com/articles/10.1186/cc13771
Therapeutic hypothermia for anoxic brain injury following cardiac arrest: A cool transition toward cardiopulmonary cerebral...
TY - JOUR. T1 - Therapeutic hypothermia for anoxic brain injury following cardiac arrest. T2 - A cool transition toward cardiopulmonary cerebral resuscitation. AU - Broccard, Alain. PY - 2006/7/1. Y1 - 2006/7/1. KW - Anoxic brain injury. KW - Cardiac arrest. KW - Cardiopulmonary resuscitation. KW - Coma. KW - Human. KW - Retrospective study. KW - Therapeutic hypothermia. UR - http://www.scopus.com/inward/record.url?scp=33745586041&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=33745586041&partnerID=8YFLogxK. U2 - 10.1097/01.CCM.0000226836.72913.C4. DO - 10.1097/01.CCM.0000226836.72913.C4. M3 - Editorial. C2 - 16801865. AN - SCOPUS:33745586041. VL - 34. SP - 2008. EP - 2009. JO - Critical Care Medicine. JF - Critical Care Medicine. SN - 0090-3493. IS - 7. ER - ...
https://minnesota-staging.pure.elsevier.com/en/publications/therapeutic-hypothermia-for-anoxic-brain-injury-following-cardiac
MED XENXIA =: Cerebral Resuscitation After Cardiocirculatory ArrestMED XENXIA =: Cerebral Resuscitation After Cardiocirculatory Arrest
Neuronal injury is one of the key factors in determining outcome after cardiac arrest. Cerebral resuscitation starts with rapid restoration of spontaneous circulation by immediate CPR and defibrillation and continues in the postresuscitation period. Basic measures consist of good critical care practice, such as maintaining normotension, normoglycemia, and normocapnia. In addition, several more specific postresuscitation treatment options have been explored in recent years. All therapies for cerebral resuscitation must face the challenge presented by the complex pathophysiological network, which is activated by global ischemia. An effective therapy should act on multiple pathways simultaneously. This is what therapeutic hypothermia does. Two large randomized clinical trials have proven that mild therapeutic hypothermia is effective in improving both survival and neurological outcome of patients after out-of-hospital cardiac arrest. Mild therapeutic hypothermia of 32°C-34°C for 12-24 h is, ...
http://lieliesa90.blogspot.com/2012/12/cerebral-resuscitation-after.html
How Therapeutic Hypothermia Works | HowStuffWorksHow Therapeutic Hypothermia Works | HowStuffWorks
During therapeutic hypothermia, doctors reduce a patients body temperature to prevent cellular damage. See how therapeutic hypothermia saves lives.
https://health.howstuffworks.com/medicine/therapeutic-hypothermia.htm
Enhanced Neuroprotective Effects by Inter-Ischemia Hypothermia in Cerebral Stroke by Hangil Lee, Yun Han et al.Enhanced Neuroprotective Effects by Inter-Ischemia Hypothermia in Cerebral Stroke by Hangil Lee, Yun Han et al.
Background and Purpose. Studies have shown that inter-ischemia hypothermia is able to reduce the size of myocardial infarctions and improve their clinical outcomes. The present study determined whether inter-ischemia hypothermia induced by pharmacological approach induced stronger neuroprotection in ischemic brains. Methods. Adult male Sprague-Dawley rats were studied in 4 groups: (1) sham; (2) stroke; (3) stroke treated with pharmacological hypothermia before reperfusion (inter-ischemia hypothermia); and (4) stroke treated with pharmacological hypothermia after reperfusion is initiated (inter-reperfusion hypothermia). The combination of chlorpromazine and promethazine with dihydrocapsaicin was used to induce hypothermia. To compare the neuroprotective effects of drug-induced hypothermia between the groups, brain damage was evaluated using infarct volume and neurological deficits. In addition, mRNA expressions of NADPH oxidase subunits and glucose transporter subtypes were determined by real-time PCR.
https://digitalcommons.wayne.edu/som_srs/41/
Postischemic hypothermia and IL-10 treatment provide long-lasting neuroprotection of CA1 hippocampus following transient global...
TY - JOUR. T1 - Postischemic hypothermia and IL-10 treatment provide long-lasting neuroprotection of CA1 hippocampus following transient global ischemia in rats. AU - Dietrich, W. Dalton. AU - Busto, Raul. AU - Bethea, John R.. N1 - Funding Information: This study was supported by U.S. PHS Grants NS05820 and NS27127, grants from the Paralyzed Veterans of America (1890-01), the American Paralysis Association (BA1-9802-2), and The Miami Project to Cure Paralysis. We gratefully appreciate Dr. Narula and Schering-Plough Pharmaceuticals for supplying the IL-10 for these studies. The authors thank Isabel Saul and Susan Kraydieh for technical support and Charlaine Rowlette for word processing and editorial assistance.. PY - 1999/8. Y1 - 1999/8. N2 - Experimental studies have demonstrated that postischemic therapeutic interventions may delay rather than provide long-lasting neuroprotection. The purpose of this study was to determine whether mild hypothermia (33-34°C) combined with the anti-inflammatory ...
https://miami.pure.elsevier.com/en/publications/postischemic-hypothermia-and-il-10-treatment-provide-long-lasting
Ontogeny of a surgical technique: Robotic kidney transplantation with regional hypothermia. - Nuffield Department of Surgical...
INTRODUCTION: Innovation is a hallmark of surgical practice. It is generally accepted that a new procedure will undergo technical changes during its evolution; however, quantitative accounts of the process are limited. METHODS: Multiple groups, including our own, have recently described a minimally-invasive approach to conventional kidney transplantation (KT) operation. Unique to our experience is a structured development of the technique within the confines of a safe surgical innovation framework - the IDEAL framework (idea, development, exploration, assessment, long-term monitoring; stages 0-4). We here provide a first-hand narrative of the progress of robotic KT operation from preclinical trial to clinical application. RESULTS: Overall, 54 patients underwent robotic KT with regional hypothermia successfully. Major technical changes including selection of optimal patient position (flank vs. lithotomy), robotic instrumentation, vascular occlusion method (bulldog vs. tourniquet) and suture material
https://www.nds.ox.ac.uk/publications/585897
Changes In The Electroretinogram During Ischemia-reperfusion In Normothermic And Hypothermic Rats | IOVS | ARVO JournalsChanges In The Electroretinogram During Ischemia-reperfusion In Normothermic And Hypothermic Rats | IOVS | ARVO Journals
Abstract: : Purpose: The present study was designed to examine the changes in the electroretinogram (ERGs) during postischemic reperfusion in young (4 months old) and aged (over 18 months old) Wistar rats under normothermic and hypothermic conditions. Methods: The ERG responses to single white light flashes were recorded by Ag/AgCl electrodes placed on the cornea. Ocular ischemia was induced by the elevation of intraocular pressure (IOP) from 15 mmHg to 80 mmHg for 2 hours. In the hypothermia groups, the rectal temperature was decreased from 38.5 °C to 31.5 °C by using a domestic cooling pad throughout the experiments. Results: Exposure to 80 mmHg of IOP decreased the choroidal blood flow to 40 - 60% of the baseline value. In the young rats, the normalized amplitude of b-wave decreased during ischemia to 60.6±3.0% of the baseline value under normothermic condition and to 70.8±5.3% under hypothermic condition. During reperfusion, the amplitude of the b-wave recovered to the baseline level by ...
http://iovs.arvojournals.org/article.aspx?articleid=2419059
Plus itPlus it
The effects of small variations in brain temperature have been tested in a number of stroke and brain injury models. For example, intraischemic hypothermia after transient global ischemia protected the CA1 hippocampus and dorsolateral striatum from neuronal necrosis (142) and attenuated cognitive and sensory motor deficits (143). In dogs, mild hypothermia at 34°C also resulted in significant improvement in neurologic function after cardiac arrest (144). Mild temperature reductions dramatically reduced infarct volume after transient focal ischemia (145, 146), whereas profound temperature reductions (24°C) or extended periods of mild hypothermia were required to reduce infarct volume after permanent focal ischemia (147, 148).. One of the limitations of postischemic hypothermia appears to be the therapeutic window. Although dramatic protection is observed if hypothermia is induced during or immediately after the ischemic insult, lesser degrees of protection are observed as a delay in the ...
http://www.ajnr.org/content/25/2/181
Hypothermia for Neonatal Encephalopathy Lowers Death Rate Wi... : Neurology TodayHypothermia for Neonatal Encephalopathy Lowers Death Rate Wi... : Neurology Today
Dr. Shankaran is continuing to study the hypothermia therapy. In a study submitted for publication that involves the same two groups of babies, MRIs tend to be more favorable for the hypothermia group, she said. Her team is also looking at variations on how best to use hypothermia. For instance, they are studying whether more time - 120 hours instead of 72 - and a lower temperature - 32 degrees instead of 33.5 - might deliver better results.. Donna Ferriero, MD, the W.H. and Marie Wattis Distinguished Professor and chair of the department of pediatrics at the University of California, San Francisco, said it is not fully understood why hypothermia therapy helps prevent brain injury in babies.. We still dont know the true mechanism at work, she told Neurology Today. We think we are slowing the metabolism and thus ultimately preventing cell death.. Dr. Ferriero was part of a research team that investigated the use of Cool-Cap, a brain-cooling cap that works on the same principle as whole-body ...
http://journals.lww.com/neurotodayonline/Fulltext/2012/07190/Hypothermia_for_Neonatal_Encephalopathy_Lowers.2.aspx
Numerical Analysis of Brain Hypothermia Using a Vascular Model in the Neck | Summer Bioengineering Conference | ASME Digital...Numerical Analysis of Brain Hypothermia Using a Vascular Model in the Neck | Summer Bioengineering Conference | ASME Digital...
In recent years, mild or moderate hypothermia has been proposed for clinical use as an adjunct for achieving protection from cerebral ischemia and traumatic brain injury. Clinically feasible brain cooling methods include a head hood or helmet with chemical cooling, head immersion in ice water, nasophyaryngeal cooling after tracheal intubations, etc. Under normal conditions it has been shown that temperature along the common and internal carotid arteries does not change significantly due to relatively small heat exchange surface of the blood vessels and high flow velocity of the blood. However, when the neck and brain surfaces are cold due to wearing external cooling garments, heat loss from the common and internal carotid arteries may result in arterial blood cooling before the blood enters the Circle of Willis [Zhu 2000]. ...
https://asmedigitalcollection.asme.org/SBC/proceedings-abstract/SBC2008/43215/249/287104
Clinical Trials Registry | Internet Stroke Center
10 patients received hypothermia, while 9 were normothermic controls. It took an average of 3.5 hours to reach the target temperature of 32º C. In 9 out of 10 patients, the target was overshot, and the entire cooling and rewarming process lasted an average of 47.4 hours. There was a measurable, but non-statistically significant trend (P = 0.14) towards better clinical outcome in the hypothermic group: 50% of the hypothermic patients and 90% of the normothermic patients had bad outcomes. There was also a trend towards reduced infarct volume in the hypothermic cohort. Sinus bradycardia was the only complication to occur with a significantly higher frequency in the hypothermia group than in the control group. Researchers conclude that induced moderate hypothermia in acute ischemic stroke is both feasible and safe. A larger study of poststroke cooling is underway.. ...
http://www.strokecenter.org/trials/clinicalstudies/cooling-acute-ischemic-brain-damage-pilot/results
Postischemic hypothermia protects against loss of agrin and SPARC from the vascular basement membrane in global cerebral...Postischemic hypothermia protects against loss of agrin and SPARC from the vascular basement membrane in global cerebral...
Postischemic hypothermia protects against loss of agrin and SPARC from the vascular basement membrane in global cerebral ischemia
https://nrc-publications.canada.ca/eng/view/object/?id=f9e9ce50-b082-4c44-a109-78fc2599f8dc
Mild Hypothermic Circulatory Arrest with Lower Body Perfusion for Total Arch Replacement Via Upper Hemisternotomy in Acute Type...Mild Hypothermic Circulatory Arrest with Lower Body Perfusion for Total Arch Replacement Via Upper Hemisternotomy in Acute Type...
Algarni KD, Yanagawa B, Rao V, Yau TM. 2014. Profound hypothermia compared with moderate hypothermia in repair of acute type A aortic dissection. The Journal of Thoracic and Cardiovascular Surgery. 148(6):2888-94. Angeloni E, Melina G, Refice SK, Roscitano A, Capuano F, Comito C, et al. 2015. Unilateral Versus Bilateral Antegrade Cerebral Protection During Aortic Surgery: An Updated Meta-Analysis. The Annals of Thoracic Surgery. 99(6):2024-31. Ariyaratnam P, Loubani M, Griffin SC. 2015. Minimally invasive aortic valve replacement: Comparison of long-term outcomes. Asian Cardiovascular and Thoracic Annals. 23(7):814-21. Candaele S, Herijgers P, Demeyere R, Flameng W, Evers G. 2003. Chest pain after partial upper versus complete sternotomy for aortic valve surgery. ACTA CARDIOL. 58(1):17-21. Guo J, Wang Y, Zhu J, Cao J, Chen Z, Li Z, et al. 2014. Right axillary and femoral artery perfusion with mild hypothermia for aortic arch replacement. J CARDIOTHORAC SURG. 9(1):94. Jiang H, Liu Y, Yang Z, Ge ...
https://journal.hsforum.com/index.php/HSF/article/view/3729
Combination EPO/Hypothermia Therapy | HIE Treatment ResearchCombination EPO/Hypothermia Therapy | HIE Treatment Research
A new study shows how high-dose erythropoietin (EPO) can work together with hypothermia therapy to help babies with hypoxic ischemic encephalopathy (HIE).
https://www.abclawcenters.com/blog/2016/05/16/erythropoietin-epo-and-hypothermia-therapy-for-hie/
Brain Circulation : Table of ContentsBrain Circulation : Table of Contents
OBJECTIVE: Mild hypothermia has a protective effect on ischemic stroke, but the mechanisms remain elusive. Here, we investigated microRNA (miRNA) profiles and the specific role of miRNAs in ischemic stroke treated with mild hypothermia. MATERIALS AND METHODS: Male adult Sprague Dawley rats were subjected to focal transient cerebral ischemia. Mild hypothermia was induced by applying ice packs around the neck and head of the animals. miRNAs expression profiles were detected in ischemic stroke treated with mild therapeutic hypothermia through miRNA chips. Reverse transcription-polymerase chain reaction (RT-PCR) was used to verify the change of miRNA array. Western blot and adenosine triphosphate (ATP) assay kits were used to detect the changes of protein expression and ATP levels, respectively. miR-15b mimic and its control were injected into the right lateral ventricle 60 min before the induction of ischemia. RESULTS: The results showed that mild hypothermia affected miRNAs profiles expression. We ...
http://www.braincirculation.org/showbackissue.asp?issn=2394-8108
Publications - Dr Cleo KontoravdiPublications - Dr Cleo Kontoravdi
Sou SN, Lee K, Nayyar K, Polizzi KM, Sellick C, Kontoravdi Cet al., 2017, Exploring cellular behavior under transient gene expression and its impact on mAb productivity and Fc-glycosylation., Biotechnol Bioeng Transient gene expression (TGE) is a methodology employed in bioprocessing for the fast provision of recombinant protein material. Mild hypothermia is often introduced to overcome the low yield typically achieved with TGE and improve specific protein productivity. It is therefore of interest to examine the impact of mild hypothermic temperatures on both the yield and quality of transiently expressed proteins and the relationship to changes in cellular processes and metabolism. In this study, we focus on the ability of a Chinese hamster ovary cell line to galactosylate a recombinant monoclonal antibody (mAb) product. Through experimentation and flux balance analysis, our results show that TGE in mild hypothermic conditions led to a 76% increase in qP compared to TGE at 36.5°C in our ...
http://www.imperial.ac.uk/people/cleo.kontoravdi98/publications.html
Treatment of asphyxiated newborns with moderate hypothermia in routine clinical practice: how cooling is managed in the UK...
BACKGROUND: This is a phase 4 study of infants registered with the UK TOBY Cooling Register from December 2006 to February 2008. The registry was established on completion of enrolLment to the TOBY randomised trial of treatment with whole body hypothermia following perinatal asphyxia at the end of November 2006. METHODS: We collected information about patient characteristics, condition at birth, resuscitation details, severity of encephalopathy, hourly temperature record, clinical complications and outcomes before hospital discharge. RESULTS: 120 infants born at a median of 40 (IQR 38-41) weeks gestation and weighing a median of 3287 (IQR 2895-3710) g at birth were studied. Cooling was started at a median of 3 h 54 min (IQR 2 h-5 h 32 min) after birth. All but three infants underwent whole body cooling. The mean (SD) rectal temperature from 6 to 72 h of the cooling period was 33.57 degrees C (0.51 degrees C). The daily encephalopathy score fell: median (IQR) 11 (6-15), 9.7 (5-14), 8 (5-13) and 7 (2-12)
https://www.ndph.ox.ac.uk/publications/236862
Research Group Critical Care and Cerebral Resuscitation<...Research Group Critical Care and Cerebral Resuscitation<...
The research aims to unravel the mechanisms of the neuroprotective effect of mild hypothermia in animal models of global and focal cerebral ischemia, and to translate the experimental findings to the clinical approach of patients with global and focal cerebral ischemia. For the experimental work, a close collaboration exists with the stroke research unit within the EFAR research group (S. Sarre, R. Kooijman and Y. Michotte). These experimental findings were translated to the clinical approach of patients with global cerebral ischemia (The European Hypothermia Network; The European Consortium of Resuscitative Hypothermia Research) as well as patients with focal cerebral ischemia (Therapeutic hypothermia to improve neurological outcome in ischemie stroke in IWT project 2006-2009).. This translation to clinical practice has been supported by a recent Society of Critical Care Medicine consensus about mild therapeutic hypothermia.. In the near future the focus will be on the search of young ...
https://researchportal.vub.be/en/organisations/research-group-critical-care-and-cerebral-resuscitation
hypothermia - Postshypothermia - Posts
hypothermia - MedHelps hypothermia Center for Information, Symptoms, Resources, Treatments and Tools for hypothermia. Find hypothermia information, treatments for hypothermia and hypothermia symptoms.
http://www.medhelp.org/tags/show/3755/hypothermia?section=subjects
Pulsatile perfusion improves regional myocardial blood flow during and after hypothermic cardiopulmonary bypass in a neonatal...
TY - JOUR. T1 - Pulsatile perfusion improves regional myocardial blood flow during and after hypothermic cardiopulmonary bypass in a neonatal piglet model. AU - Ündar, Akif. AU - Masai, Takafumi. AU - Yang, Shuang Qiang. AU - Eichstaedt, Harald C.. AU - McGarry, Mary Claire. AU - Vaughn, William K.. AU - Fraser, Charles D.. PY - 2002/1/1. Y1 - 2002/1/1. N2 - Pediatric myocardial related morbidity and mortality after cardiopulmonary bypass (CPB) are well documented, but the effects of pulsatile perfusion (PP) versus nonpulsatile perfusion (NPP) on myocardial blood flow during and after hypothermic CPB are unclear. After investigating the effects of PP versus NPP on myocardial flow during and after hypothermic CPB, we quantified PP and NPP pressure and flow waveforms in terms of the energy equivalent pressure (EEP) for direct comparison. Ten piglets underwent PP (n = 5) or NPP (n = 5). After initiation of CPB, all animals underwent 15 minutes of core cooling (25°C), 60 minutes of hypothermic CPB ...
https://pennstate.pure.elsevier.com/en/publications/pulsatile-perfusion-improves-regional-myocardial-blood-flow-durin
Effect of mild hypothermia on ischemia-induced release of neurotransmitters and free fatty acids in rat brain<...
TY - JOUR. T1 - Effect of mild hypothermia on ischemia-induced release of neurotransmitters and free fatty acids in rat brain. AU - Busto, Raul. AU - Globus, Mordecai Y.T.. AU - Dietrich, W. Dalton. AU - Martinez, Elena. AU - Valdes, Isabel. AU - Ginsberg, Myron D.. N1 - Copyright: Copyright 2017 Elsevier B.V., All rights reserved.. PY - 1989/7. Y1 - 1989/7. N2 - We have demonstrated previously that mild intraischemic hypothermia confers a marked protective effect on the final histopathological outcome. The present study was carried out to evaluate whether this protective effect involves changes in the degree of local cerebral blood flow reductions, tissue accumulation of free fatty acids, or alterations in the extracellular release of glutamate and dopamine. Rats whose intraischemic brain temperature was maintained at 36°C, 33°C, or 30°C were subjected to 20 minutes of ischemia by four-vessel occlusion combined with systemic hypotension. Levels of local cerebral blood flow, as measured ...
https://miami.pure.elsevier.com/en/publications/effect-of-mild-hypothermia-on-ischemia-induced-release-of-neurotr
Prospective randomized trial of normothermic versus hypothermic cardiopulmonary bypass on cognitive function after coronary...Prospective randomized trial of normothermic versus hypothermic cardiopulmonary bypass on cognitive function after coronary...
Prospective randomized trial of normothermic versus hypothermic cardiopulmonary bypass on cognitive function after coronary artery bypass graft surgery.
https://scholars.duke.edu/display/pub734517
Cerebral blood flow during low-flow hypothermic cardiopulmonary bypass in baboons<...Cerebral blood flow during low-flow hypothermic cardiopulmonary bypass in baboons<...
TY - JOUR. T1 - Cerebral blood flow during low-flow hypothermic cardiopulmonary bypass in baboons. AU - Schwartz, A. E.. AU - Kaplon, R. J.. AU - Young, W. L.. AU - Sistino, J. J.. AU - Kwialkowski, P.. AU - Michler, R. E.. PY - 1994/1/1. Y1 - 1994/1/1. N2 - Background: Neurologic injury after cardiopulmonary bypass (CPB) is a frequent and devastating complication of cardiothoracic surgery. Disordered cerebral hemodynamics during CPB has been implicated as an important factor in the etiology of these injuries. Evidence of disordered cerebral hemodynamics includes reports of a progressive time-dependent decrease in cerebral blood flow (CBF) during stable full-flow CPB. Low-flow hypothermic CPB has become a preferred technique for the management of pediatric patients undergoing surgical repair of complex cardiac lesions. Because CBF is already substantially reduced with the onset of low-flow CPB, we determined if a similar progressive decline in CBF occurs during the low-flow state. Methods: After ...
https://einstein.pure.elsevier.com/en/publications/cerebral-blood-flow-during-low-flow-hypothermic-cardiopulmonary-b-2
Evidence for a significant myocardial contribution to total metabolic burden during hypothermic cardiopulmonary bypass: a study...
Objective: We assessed the causes of imbalance of oxygen transport by continuously measuring oxygen consumption (VO2) during hypothermic cardiopulmonary bypass (CPB) in pigs. Methods: Six pigs (17.2±1.6 kg) underwent hypothermic (32°C) CPB for 180 min with 120 min of aortic crossclamping (ACC). An AMIS 2000 mass spectrometer was adapted for the on-line measurement of VO2. Arterial lactate was measured at the beginning of CPB, the end of hypothermia, before and 10 min after ACC release, 20 min later, and at the end of CPB. Results: Arterial lactate increased from 1.8±0.7 to 5.1±1.8 mmol/L during CPB. Hypothermia reduced VO2 by 0.63±0.29 ml/min/kg per °C, but lactate increased to 4.2±1.5 mmol/L ( ...
http://connection.ebscohost.com/c/articles/18281899/evidence-significant-myocardial-contribution-total-metabolic-burden-during-hypothermic-cardiopulmonary-bypass-study-continuously-measured-oxygen-consumption-arterial-lactate-levels-pigs
Neuroprotective body hypothermia among newborns with hypoxic ischemic encephalopathy: three-year experience in a tertiary...Neuroprotective body hypothermia among newborns with hypoxic ischemic encephalopathy: three-year experience in a tertiary...
DISCUSSION. This study reports on a three-year experience of administering hypothermia therapy to asphyxiated newborns in a tertiary-level university hospital. The criteria for infant inclusion and exclusion were based on previous studies on safety. The gestational age for inclusion in the study (more than 35 weeks) made it possible to differentiate encephalopathy attributed to perinatal hypoxia from other problems relating to prematurity.17 Hypothermia is applied within the first six hours of life because this is the therapeutic window within which the neu-roprotective effect relating to reduction of cerebral metabolism, reduction of excitatory neurotransmitter activity, suppression of free radical release, inhibition of the apoptotic process and reduction of the release of inflammatory mediators is most effective. In general, the efficacy of the neuroprotective effect diminishes if the cooling period starts after the therapeutic window, but evidence suggests that the neurological injury in HIE ...
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802015000400314&lng=en&nrm=iso
Hypoxia-Ischemia and Hypothermia Independently and Interactively Affect Neuronal Pathology in Neonatal Piglets with Short-Term...
TY - JOUR. T1 - Hypoxia-Ischemia and Hypothermia Independently and Interactively Affect Neuronal Pathology in Neonatal Piglets with Short-Term Recovery. AU - OBrien, Caitlin E.. AU - Santos, Polan T.. AU - Kulikowicz, Ewa. AU - Reyes, Michael. AU - Koehler, Raymond C.. AU - Martin, Lee J.. AU - Lee, Jennifer K.. PY - 2019/9/1. Y1 - 2019/9/1. N2 - Therapeutic hypothermia is the standard of clinical care for moderate neonatal hypoxic-ischemic encephalopathy. We investigated the independent and interactive effects of hypoxia-ischemia (HI) and temperature on neuronal survival and injury in basal ganglia and cerebral cortex in neonatal piglets. Male piglets were randomized to receive HI injury or sham procedure followed by 29 h of normothermia, sustained hypothermia induced at 2 h, or hypothermia with rewarming during fentanyl-nitrous oxide anesthesia. Viable and injured neurons and apoptotic profiles were counted in the anterior putamen, posterior putamen, and motor cortex at 29 h after HI injury ...
https://jhu.pure.elsevier.com/en/publications/hypoxia-ischemia-and-hypothermia-independently-and-interactively-
Hypothermia for neonatal hypoxic ischemic encephalopathy: an updated systematic review and meta-analysisHypothermia for neonatal hypoxic ischemic encephalopathy: an updated systematic review and meta-analysis
Hypothermia improves survival and neurodevelopment in newborns with moderate to severe HIE.Total body cooling and selective head cooling are effective methods in treating newborns with HIE. Clinicians should consider offering therapeutic hypothermia as part of routine clinical care to these newborns …
https://pubmed.ncbi.nlm.nih.gov/22312166/?dopt=Abstract
Ontogeny of a surgical technique: Robotic kidney transplantation with regional hypothermia<...
TY - JOUR. T1 - Ontogeny of a surgical technique. T2 - Robotic kidney transplantation with regional hypothermia. AU - Sood, Akshay. AU - McCulloch, Peter. AU - Dahm, Philipp. AU - Ahlawat, Rajesh. AU - Jeong, Wooju. AU - Bhandari, Mahendra. AU - Menon, Mani. N1 - Publisher Copyright: © 2015 IJS Publishing Group Limited. Copyright: Copyright 2017 Elsevier B.V., All rights reserved.. PY - 2016/1/1. Y1 - 2016/1/1. N2 - Introduction: Innovation is a hallmark of surgical practice. It is generally accepted that a new procedure will undergo technical changes during its evolution; however, quantitative accounts of the process are limited. Methods: Multiple groups, including our own, have recently described a minimally-invasive approach to conventional kidney transplantation (KT) operation. Unique to our experience is a structured development of the technique within the confines of a safe surgical innovation framework - the IDEAL framework (idea, development, exploration, assessment, long-term ...
https://minnesota-staging.pure.elsevier.com/en/publications/ontogeny-of-a-surgical-technique-robotic-kidney-transplantation-w
Assessment of ischemic damage and neuroprotection in an experimental model of forebrain ischemia - Memorial University...Assessment of ischemic damage and neuroprotection in an experimental model of forebrain ischemia - Memorial University...
In this dissertation, two treatments, intraischemic hypothermia and glutamate receptor blockade, were evaluated for neuroprotective efficacy against global ischemia. Since the standard assessment of ischemic damage using only histological outcome reveals nothing about function, I used multiple outcome measures including behaviour and electrophysiology, as well as a histological evaluation. In order to further increase the strength of this approach, multiple assessments were made in the same animals. -- Intraischemic hypothermia induced by selectively cooling the brain conveyed both long-lasting protection against functional loss as well as cell loss. These findings provide a strong argument for the implementation of hypothermia in cases where the occurrence of an ischemic episode can be predicted before it occurs (e.g. elective cardiac/neuro-surgery). However, most cases of ischemia, or stroke, occur without warning thereby precluding the use of intraischemic hypothermia. -- NBQX, a glutamate ...
https://research.library.mun.ca/11154/
Neonatal neurobehavioral abnormalities and MRI brain injury in encephalopathic newborns treated with hypothermia<...
TY - JOUR. T1 - Neonatal neurobehavioral abnormalities and MRI brain injury in encephalopathic newborns treated with hypothermia. AU - Coleman, Maya B.. AU - Glass, Penny. AU - Brown, Judy. AU - Kadom, Nadja. AU - Tsuchida, Tammy. AU - Scafidi, Joseph. AU - Chang, Taeun. AU - Vezina, Gilbert. AU - Massaro, An N.. PY - 2013/9/1. Y1 - 2013/9/1. N2 - Background: Neonatal Encephalopathy (NE) is a prominent cause of infant mortality and neurodevelopmental disability. Hypothermia is an effective neuroprotective therapy for newborns with encephalopathy. Post-hypothermia functional-anatomical correlation between neonatal neurobehavioral abnormalities and brain injury findings on MRI in encephalopathic newborns has not been previously described. Aim: To evaluate the relationship between neonatal neurobehavioral abnormalities and brain injury on magnetic resonance imaging (MRI) in encephalopathic newborns treated with therapeutic hypothermia. Study design: Neonates with hypoxic ischemic encephalopathy ...
https://jhu.pure.elsevier.com/en/publications/neonatal-neurobehavioral-abnormalities-and-mri-brain-injury-in-en
First aid - Hypothermia
Hypothermia happens when someones body temperature drops below 35°C (95°F). Normal body temperature is around 37°C (98. 6°F). Hypothermia can become life-threatening quickly, so its important to treat someone with hypothermia straight away. Severe hypothermia, when the body temperature falls below 30°C (86°F), is often fatal. When your body temperature drops,your heart,nervous system and other organs cant work normally. Left untreated, hypothermia can eventually lead to complete failure of your heart and respiratory system and to death. Hypothermia is usually caused by being in a cold environment for a long time. This could be from staying outdoors in cold conditions, falling into cold water, or from living in a poorly heated house. Elderly people, babies, homeless people and anyone who is thin and frail or not able to move around easily are particularly vulnerable. Shivering is likely the first thing youll notice as the temperature starts to drop because its your bodys automatic defense
http://www.ehsdb.com/first-aid---hypothermia.php
Global Hypothermic Machine Perfusion Preservation Sales Market Report 2021 : ReportsnReports
[100 Pages Report] Check for Discount on Global Hypothermic Machine Perfusion Preservation Sales Market Report 2021 report by QYResearch Group. Notes: Sales, means the sales volume of Hypothermic Machine Perfusion...
http://www.reportsnreports.com/reports/660023-global-hypothermic-machine-perfusion-preservation-sales-market-report-2021.html
A Human Thermoregulation Simulator for Calibrating Water-Perfused Cooling Pad Systems for Therapeutic Hypothermia | Journal of...A Human Thermoregulation Simulator for Calibrating Water-Perfused Cooling Pad Systems for Therapeutic Hypothermia | Journal of...
The induction of a mild reduction in body core temperature has been demonstrated to provide neuroprotection for patients who have suffered a medical event resulting in ischemia to the brain or vital organs. Temperatures in the range of 32-34 °C provide the required level of protection and can be produced and maintained by diverse means for periods of days. Rewarming from hypothermia must be conducted slowly to avoid serious adverse consequences and usually is performed under control of the thermal therapeutic device based on a closed-loop feedback strategy based on the patients core temperature. Given the sensitivity and criticality of this process, it is important that the device control system be able to interact with the human thermoregulation system, which itself is highly nonlinear. The therapeutic hypothermia device must be calibrated periodically to ensure that its performance is accurate and safe for the patient. In general, calibration processes are conducted with the hypothermia ...
http://medicaldevices.asmedigitalcollection.asme.org/article.aspx?articleid=2633209&resultClick=1
Prior hypothermia attenuates malignant hyperthermia in susceptible swine<...Prior hypothermia attenuates malignant hyperthermia in susceptible swine<...
TY - JOUR. T1 - Prior hypothermia attenuates malignant hyperthermia in susceptible swine. AU - Iaizzo, Paul A.. AU - Kehler, Chris H.. AU - Carr, Richard J.. AU - Sessler, Daniel I.. AU - Belani, Kumar G.. PY - 1996/4/19. Y1 - 1996/4/19. N2 - This study was designed to determine the extent by which mild or moderate hypothermia attenuates the triggering of malignant hyperthermia (MH) induced by the combined administration of halothane and succinylcholine. Sixteen susceptible swine were initially anesthetized with nontriggering drugs and then either kept normothermic (≃38°C, n = 6) or cooled to induce mild (≃35°C, n = 6), or moderate (≃33°C, n = 4) hypothermia. Next, after a 30- min control period, the normothermic and mildly hypothermic animals were administered 1 minimum alveolar anesthetic concentration (MAC) halothane followed by a bolus dose of succinylcholine (2 mg/kg). Within 10 min all normothermic animals developed fulminant MH, whereas the onset of MH was slowed or was absent in ...
https://experts.umn.edu/en/publications/prior-hypothermia-attenuates-malignant-hyperthermia-in-susceptibl
Use of Hypothermia Does Not Improve Outcomes for Adults With Severe Meningitis, May Be Harmful | Infection Control TodayUse of Hypothermia Does Not Improve Outcomes for Adults With Severe Meningitis, May Be Harmful | Infection Control Today
Bruno Mourvillier, MD, of the Université Paris Diderot, Sorbonne Paris Cité, Paris, and colleagues conducted a study to examine whether treatment with hypothermia would improve the functional outcome of comatose patients with bacterial meningitis compared with standard care.  Among adults with bacterial meningitis, the death rate and frequency of neurologic complications are high, indicating the need for new therapeutic approaches. Clinical trials of patients with trauma who were treated with hypothermia have shown a decrease of intracranial pressure, suggesting a potential benefit of this technique in bacterial meningitis, according to background information in the article.  The randomized trial conducted in 49 intensive care units in France between February 2009 and November 2011 assessed 130 patients for eligibility and randomized 98 comatose adults with community acquired bacterial meningitis to the hypothermia group, where patients received a loading dose of 39°F cold saline and
https://www.infectioncontroltoday.com/view/use-hypothermia-does-not-improve-outcomes-adults-severe-meningitis
Whole-body hypothermia reduces risk of death in Encephalopathy in infantsWhole-body hypothermia reduces risk of death in Encephalopathy in infants
Whole-body hypothermia reduces the risk of death or disability in infants with moderate or severe hypoxic ischemic encephalopathy
http://www.medindia.net/news/view_news_main.asp?x=5303
hypoxic-ischemic encephalopathy Archiveshypoxic-ischemic encephalopathy Archives
Anemia Drug May Help Babies at High-Risk of Brain Injury. Anemia Drug May Help Babies at High-Risk of Brain Injury A new study suggests that babies born with hypoxic-ischemic encephalopathy (HIE) that were treated with erythropoietin, a synthetic version of the hormone that stimulates red blood cell production, experienced lesser brain injuries. Researchers indicate that erythropoietin infusions coupled with hypothermia treatment contributed to fewer incidents of brain injury, […]. ...
https://www.injuryfrombirth.com/tag/hypoxic-ischemic-encephalopathy/
The Effects of Hypothermia in Pregnant Rats: A Preliminary Report by Roger A. Glover Jr., Chan H. Park et al.The Effects of Hypothermia in Pregnant Rats: A Preliminary Report by Roger A. Glover Jr., Chan H. Park et al.
We have evaluated the effects of varying degrees and durations of hypothermia, combined with anesthesia, on pregnant rats of the Sherin Wistar Strain. Moderate (surgical) and intermediate hypothermia, with ether anesthesia, were safe for both fetus and mother. With pentobarbital anesthesia, however, there were harmful effects, depending on the depth and duration of hypothermia; moderate hypothermia increased fetal and maternal mortality. The combination of CO₂ narcosis and deep hypothermia induced no ill effects.
https://scholarscompass.vcu.edu/mcvq/vol6/iss1/7/
Therapeutic hypothermia in acute traumatic spinal cord injury | Journal of the Royal Army Medical Corps
Therapeutic hypothermia is already widely acknowledged as an effective neuroprotective intervention, especially within the acute care setting in relation to conditions such as cardiac arrest and neonatal encephalopathy. Its multifactorial mechanisms of action, including lowering metabolic rate and reducing acute inflammatory cellular processes, ultimately provide protection for central nervous tissue from continuing injury following ischaemic or traumatic insult. Its clinical application within acute traumatic spinal cord injury would therefore seem very plausible, it having the potential to combat the pathophysiological secondary injury processes that can develop in the proceeding hours to days following the initial injury. As such it could offer invaluable assistance to lessen subsequent sensory, motor and autonomic dysfunction for an individual affected by this devastating condition. Yet research surrounding this interventions applicability in this field is somewhat lacking, the majority ...
http://jramc.bmj.com/content/early/2017/10/12/jramc-2017-000792.full
Surgery for acute aortic dissection using moderate hypothermia and antegrade cerebral perfusion via the right subclavian artery...Surgery for acute aortic dissection using moderate hypothermia and antegrade cerebral perfusion via the right subclavian artery...
Temelkovska, Aleksandra and Kajevski, I and Hristov, Nikola and Mitrev, Zan (2010) Surgery for acute aortic dissection using moderate hypothermia and antegrade cerebral perfusion via the right subclavian artery. . (Unpublished) ...
https://eprints.ugd.edu.mk/5855/
NEJM Ask the Authors & Experts: Original Research - Therapeutic Hypothermia in Deceased Organ Donors and Kidney-Graft Function ...
Experts in Discussion about @NEJM Ask the Authors & Experts: Original Research - Therapeutic Hypothermia in Deceased Organ Donors and Kidney-Graft Function
https://medstro.com/groups/nejm-group-open-forum/discussions/159/experts
The effect of hypothermia on the expression of neurotrophin mRNA in the hippocampus following transient cerebral ischemia in...The effect of hypothermia on the expression of neurotrophin mRNA in the hippocampus following transient cerebral ischemia in...
article{f8148d83-783e-4da1-816a-c12a7ad72203, abstract = {,p,The expression of the mRNAs of nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), neurotrophin 3 (NT3) and the neurotrophin receptor, TrkB, was studied in the rat hippocampus by in situ hybridization following normothermic (37°C) and protective hypothermic (33°C) transient cerebral ischemia of 15 min duration. In the resistant dentate gyms, normothermic ischemia transiently induced NGF mRNA at around 8 h of recovery, while the NT3 mRNA levels were depressed over at least a 24-h recovery period. The levels of BDNF and TrkB were transiently and markedly elevated with a maximal expression at 24 h of recovery. Intraischemic hypothermia reduced the induction of NGF mRNA, while the increase of BDNF mRNA expression occurred earlier during recovery, and the post-ischemic NT3 mRNA depression was not affected. Also, the expression of TrkB mRNA was enhanced, and occurred concomitantly with the elevation of BDNF mRNA. In ...
https://lup.lub.lu.se/search/publication/f8148d83-783e-4da1-816a-c12a7ad72203
Systematic review and meta‐analysis of hypothermic machine perfusion versus static cold storage of kidney allografts on...Systematic review and meta‐analysis of hypothermic machine perfusion versus static cold storage of kidney allografts on...
Adequate preservation of renal allografts for transplantation is important for maintaining and improving transplant outcomes. There are two prevalent methods: hypothermic machine perfusion and static cold storage. The preferred method of storage, however, remains controversial. The objective was to review systematically the evidence comparing outcomes from these two modalities. ...
https://www.bjs.co.uk/article/systematic-review-and-meta%E2%80%90analysis-of-hypothermic-machine-perfusion-static-cold-storage-of-kidney-allografts-on-transplant-outcomes/
Hypothermia & Frostbite | Department of Recreation, Adventure and WellnessHypothermia & Frostbite | Department of Recreation, Adventure and Wellness
Treatment of mild Hypothermia - rewarm as soon as possible by any convenient means (eat, drink, put on more clothes, run around)!. Profound Hypothermia - this is a medical emergency. Your body temperature has fallen below 90F (32C) and you are incapable of rewarming yourself. At this stage your brain begins to cool and ceases to function normally. You are at risk of ventricle fibrillation (i.e., heart attack) if your friends rough handle you, re-warm you too quickly or cause you to physically exert yourself! Dont let yourself get this cold!. Frostbite - the freezing of body tissue. Frostbite is caused by sub-freezing temperatures in combination with vasoconstriction - reduced circulation to the extremities. Dehydration, certain drugs (including caffeine, nicotine and THC), hypothermia, and constrictive (tight) clothing or boots, and genetic disposition all contribute to poor circulation.. Avoid contact with metal objects and liquids such as fuels and alcohol that are super cooled (below ...
https://www.uaf.edu/draw/outdoor-adventures/additional-resources/useful-tips/hypothermia-frostbite/
Continuous electroencephalography monitoring for early prediction of neurological outcome in postanoxic patients after cardiac...Continuous electroencephalography monitoring for early prediction of neurological outcome in postanoxic patients after cardiac...
OBJECTIVE: To evaluate the value of continuous electroencephalography in early prognostication in patients treated with hypothermia after cardiac arrest.. DESIGN: Prospective cohort study.. SETTING: Medical intensive care unit.. PATIENTS: Sixty patients admitted to the intensive care unit for therapeutic hypothermia after cardiac arrest.. INTERVENTION: None.. MEASUREMENTS AND MAIN RESULTS: In all patients, continuous electroencephalogram and daily somatosensory evoked potentials were recorded during the first 5 days of admission or until intensive care unit discharge. Neurological outcomes were based on each patients best achieved Cerebral Performance Category score within 6 months. Twenty-seven of 56 patients (48%) achieved good neurological outcome (Cerebral Performance Category score 1-2).At 12 hrs after resuscitation, 43% of the patients with good neurological outcome showed continuous, diffuse slow electroencephalogram rhythms, whereas this was never observed in patients with poor ...
https://read.qxmd.com/read/22824933/continuous-electroencephalography-monitoring-for-early-prediction-of-neurological-outcome-in-postanoxic-patients-after-cardiac-arrest-a-prospective-cohort-study
Threshold for adrenomedullary activation and increased cardiac work during mild core hypothermia | Clinical Science | Portland...Threshold for adrenomedullary activation and increased cardiac work during mild core hypothermia | Clinical Science | Portland...
Postoperative hypothermia increases the incidence of ischaemic cardiac events in patients at risk, but the underlying mechanism is unclear. One possibility is increased cardiac work related to the sympathoneural or adrenomedullary hormonal responses. In awake human volunteers, the present study assessed the effects of mild core hypothermia on these responses, and on the associated changes in indices of cardiac work. A total of 11healthy men were studied on two separate days. On one day, core temperature (Tc) was decreased by the intravenous infusion of cold normal saline (4°C; 60ml/kg over 30min) through a central venous catheter. On the other day (normothermic control), warm normal saline (37°C; 60ml/kg over 30min) was given intravenously. Transthoracic echocardiograms, the sympathoneural response (noradrenaline) and the adrenomedullary response (adrenaline) were evaluated before, during and after the intravenous infusions. Echocardiography was used to measure left ventricular function and ...
https://portlandpress.com/clinsci/article-abstract/102/1/119/67216/Threshold-for-adrenomedullary-activation-and?redirectedFrom=fulltext
Use and Effectiveness of Hypothermia Blankets for Febrile Patients in the Intensive Care Unit : Clinical Infectious Diseases -...
We performed a prospective observational (noninterventional) study of hypothermia blanket use in a population of adult intensive care unit patients with body temperatures of ⩾102.5°F. Thirty-nine of ninety-four febrile episodes (in 83 patients) were treated with hypothermia blankets. Logistic regression revealed that the strongest independent predictors of hypothermia blanket use were a temperature of ⩾103.5°F (odds ratio [OR] = 17), mechanical ventilation (OR = 25), and acute central nervous system illness (OR = 7.5). Hospitalization in the medical intensive care unit was strongly associated with avoidance of this therapy (OR = 0.023). Treatment with a hypothermia blanket was ordered by a physician in only 15% of cases. The mean cooling rate was the same (0.028°F/h) for blanket-treated and control patients. Multivariate Cox regression and factorial and repeated measures of analysis of variance revealed that blanket treatment was not more effective than other cooling methods. However, ...
http://oxfordindex.oup.com/view/10.1086/513660
Annals of Cardiac AnaesthesiaAnnals of Cardiac Anaesthesia
Deep hypothermia, which is used during thoracic aortic surgery for neuroprotection, is associated with coagulation abnormalities in animal and in vitro models. However, there is a paucity of data regarding the impact of deep hypothermia duration on perioperative bleeding. The objective of the current study was to examine the relationship between the duration of deep hypothermia and perioperative bleeding. A retrospective review of 507 consecutive thoracic aortic surgery patients who had surgery with deep hypothermic circulatory arrest was performed. The degree of bleeding and coagulopathy was estimated using perioperative transfusion. Log linear modeling with Poisson regression was used to analyze the relationship between deep hypothermia duration and perioperative bleeding, while controlling for other preselected variables. There was a significant association between deep hypothermia duration and RBC transfusion (P = 0.001). There was no significant association between deep hypothermia duration ...
https://www.annals.in/showstats.asp?sabs=y&issn=0971-9784
Neonatal Ischemic Neuroprotection by Modest Hypothermia Is Associated With Attenuated Brain Acidosis | StrokeNeonatal Ischemic Neuroprotection by Modest Hypothermia Is Associated With Attenuated Brain Acidosis | Stroke
The results of this investigation demonstrate that a 2°C to 3°C reduction in intraischemic brain temperature is associated with potentially important alterations in ischemic brain metabolism and subsequent partial neuroprotection in comparison to animals studied under normothermic conditions. As indicated by the group effect, intraischemic modest hypothermia resulted in higher pHi values consistently during ischemia and for at least 30 minutes after ischemia compared with normothermic animals. Although the magnitude of difference in pHi between groups is in the order of 0.15 to 0.20 pH units, the persistence of this finding during an interval of approximately 45 minutes may be critical in attenuating potential adverse effects of brain acidosis. Among animals of both groups, clinical and histological evidence of brain injury were associated with more severe intraischemic acidosis. The results suggest that brain acidosis may be critical in the pathogenesis of neonatal ischemic brain damage, and ...
http://stroke.ahajournals.org/content/26/7/1240
Hypothermia & FrostbiteHypothermia & Frostbite
Hypothermia and frostbite are significant dangers when cold temperatures set in. The two conditions are somewhat related, but have different symptoms. Its important to know the warning signs for both, and the steps you can take to prevent and treat them. Hypothermia Hypothermia is the condition in which your core body temperature falls below what it needs to be at in order to function properly. The average body temperature of humans is around 98.6 degrees F. When you are exposed to cold temperatures, your body loses more heat than it can produce, which makes your nervous system, heart, and other organs not function properly. If the body falls below 95 degrees F, medical attention is needed. The signs of hypothermia include shivering, mental confusion, exhaustion, slurred speech, low energy, pale skin, a lowering heart and respiratory rate, and more. If you see anyone experiencing any of these, take their temperature. If it is below 95 degrees F, seek medical attention immediately. If medical care is
http://weatherology.com/articles/82/Hypothermia+%26+Frostbite.html
Surgical Technology International Online - 14 - Surgical Overview
An Hypothermia is defined as a decrease in core temperature below 35 degrees C. The well-described deleterious effects of accidental hypothermia on outcome in multiple-trauma patients contrast the beneficial effect of controlled hypothermia on organ function during ischemia in elective surgery. Experimental studies have shown that induced hypothermia during hemorrhagic shock might have beneficial effects on outcome. The beneficial effects of induced hypothermia appear to be partly mediated by the prolongation of the golden hour with prevention of hypoxic organ dysfunction. However, hypothermia also has been thought to have an impact on the immunologic response after trauma and elective surgery. Induction of hypothermia seems to decrease the release of pro-inflammatory cytokines believed to influence distant organ damage positively, and is mediated by the interaction of polymorphonuclear leucocytes (PMNL) and capillary endothelial cells. Nevertheless, the incidence of posttraumatic infectious ...
http://surgicaltechnology.com/14-Surgical-Overview.htm
Altmetric - Active body surface warming systems for preventing complications caused by inadvertent perioperative hypothermia in...
Inadvertent perioperative hypothermia is a phenomenon that can occur as a result of the suppression of the central mechanisms of temperature regulation due to anaesthesia, and of prolonged exposure of large surfaces of skin to cold temperatures in operating rooms. Inadvertent perioperative hypothermia has been associated with clinical complications such as surgical site infection and wound-healing delay, increased bleeding or cardiovascular events. One of the most frequently used techniques to prevent inadvertent perioperative hypothermia is active body surface warming systems (ABSW), which generate heat mechanically (heating of air, water or gels) that is transferred to the patient via skin contact. To assess the effectiveness of pre- or intraoperative active body surface warming systems (ABSW), or both, to prevent perioperative complications from unintended hypothermia during surgery in adults. We searched the Cochrane Central Register of Controlled Trials (CENTRAL; Issue 9, 2015); MEDLINE ...
https://cochrane.altmetric.com/details/6878722
Salem County Office of Emergency Management » Frostbite and HypothermiaSalem County Office of Emergency Management » Frostbite and Hypothermia
Frostbite is a severe reaction to cold exposure that can permanently damage its victims. A loss of feeling and a white or pale appearance in fingers, toes, or nose and ear lobes are symptoms of frostbite.. Hypothermia is a condition brought on when the body temperature drops to less than 90 degrees Fahrenheit. Symptoms of hypothermia include uncontrollable shivering, slow speech, memory lapses, frequent stumbling, drowsiness, and exhaustion.. If frostbite or hypothermia is suspected, begin warming the person slowly and seek immediate medical assistance. Warm the persons trunk first. Use your own body heat to help. Arms and legs should be warmed last because stimulation of the limbs can drive cold blood toward the heart and lead to heart failure.. Put person in dry clothing and wrap their entire body in a blanket.. Never give a frostbite or hypothermia victim something with caffeine in it (like coffee or tea) or alcohol. Caffeine, a stimulant, can cause the heart to beat faster and hasten the ...
http://readysalem.org/potential-hazards/frostbite-and-hypothermia/
Ailing runner crosses marathon finish line - seven months later - Houston ChronicleAiling runner crosses marathon finish line - seven months later - Houston Chronicle
Four hours and 13 minutes into the January race, Dixon suffered a seizure just 25 yards from the finish line. A medical team rushed her off the course, and she was taken to St. Lukes Episcopal Hospital by Life Flight. On Tuesday evening at Memorial Park, in front of her running buddies and TV cameras, Dixon ran those last 25 yards. When Dixon went into cardiac arrest, race officials notified Mulvihill that one of his team members was hospitalized. At St. Lukes, doctors used hypothermia treatment to lower her body temperature and prevent brain damage. Dixon was diagnosed with a congenital coronary anomaly; the left main artery pumping blood to her heart was on the wrong side.
http://www.chron.com/life/article/Ailing-runner-crosses-marathon-finish-line-2148519.php
EXCLUSIVE: 2 survivors in Molokai plane crash speak outEXCLUSIVE: 2 survivors in Molokai plane crash speak out
You can survive in 78deg water for a very long time, and most of the people on board swam to the shore quite quickly, and the rescuers came on the scene promptly.. Some people can survive in 78F water for a prolonged period of time, while other people in poor physical condition and/or having just suffered physical trauma often may not. The SST (Sea Surface Temperature) of 77-78°F was low enough to eventually bring about a lowering of body core temperature to the range for mild hypothermia at 90-95°F, moderate hypothermia at 82-90°F, or even severe hypothermia at 68-82°F. Trauma suffered when the aircraft ditched in the sea could very well have contributed to a more rapid onset of hypothermia as the heart rate, blood pressure, and respiratory rated dropped. Under such conditions, especially in the presence of aggravated hypoglycemia or hyperglycemia, you can see heart problems become a risk for fatality.. It is untrue to say, most of the people on board swam to the shore quite quickly. ...
http://www.freerepublic.com/focus/f-news/3102597/posts?page=27
Hypothermic circulatory arrest with moderate, deep or profound hypothermic selective antegrade cerebral perfusion: which...Hypothermic circulatory arrest with moderate, deep or profound hypothermic selective antegrade cerebral perfusion: which...
OBJECTIVE Selective antegrade cerebral perfusion (SACP) seems to be associated with a better outcome compared to hypothermic circulatory arrest (HCA) alone. This study was undertaken to evaluate the influence of different SACP temperatures on the neurological integrity. METHODS Twenty-six pigs were included in the study and assigned to 100 min HCA at 20 degrees C body temperature without (n = 6) or with either 10 degrees C (n = 6), 20 degrees C (n = 7) or 30 degrees C (n = 7) of SACP. Haemodynamics, metabolics and neurophysiology (EEG, SSEP, ICP, sagittal sinus saturation) were monitored. Animals were sacrified 4h after reperfusion and brains perfused for histological and molecular genetic assessment. RESULTS There were no clinically relevant differences in haemodynamics between groups. The rise in ICP during SACP was significantly more marked in the 30 degrees C group (p | 0.05) and remained high during the entire experiment. In the 10 degrees C group the rise in ICP was postponed, but increased
https://www.semanticscholar.org/paper/Hypothermic-circulatory-arrest-with-moderate-deep-Khaladj-Peterss/9b1ac37c90421bcf1ac9abef5ba509ea854cd57e
Retrospective study of the prevalence of postanaesthetic hypothermia in dogs | Veterinary Record
The anaesthetic records of 1525 dogs were examined to determine the prevalence of postanaesthetic hypothermia, its clinical predictors and consequences. Temperature was recorded throughout the anaesthesia. At the end of the procedure, details coded in were: hyperthermia (,39.50°C), normothermia (38.50°C-39.50°C), slight (38.49°C-36.50°C), moderate (36.49°C-34.00°C) and severe hypothermia (,34.00°C). Statistical analysis consisted of multiple regression to identify the factors that are associated with the temperature at the end of the procedure. Before premedication, the temperature was 38.7 ± 0.6°C (mean ± sd). At 60, 120 and 180 minutes from induction, the temperature was 36.7 ± 1.3°C, 36.1 ± 1.4°C and 35.8 ± 1.5°C, respectively. The prevalence of hypothermia was: slight, 51.5 per cent (95 per cent CI 49.0 to 54.0 per cent); moderate, 29.3 per cent (27.1-31.7 per cent) and severe: 2.8% (2.0-3.7%). The variables that associated with a decrease in the temperature recorded at the ...
http://veterinaryrecord.bmj.com/content/171/15/374
Hypothermia: Cold Water BoatingHypothermia: Cold Water Boating
Any victim pulled from cold water should be treated for hypothermia - this is the very dangerous and important stage of survival which is a result of cold water immersion. At this point, you should seek trained medical treatment immediately. Symptoms of hypothermia may include intense shivering, loss of coordination, mental confusion, cold and blue (cyanotic) skin, weak pulse, uncontrolled breathing, irregular heartbeat, and enlarged pupils. Once shivering stops, core body temperature begins to drop critically. Try to prevent body cooling and get the victim to a medical facility immediately.. ...
http://boatus.org/cold-water-boating/hypothermia/
Human Refrigeration - JEMSHuman Refrigeration - JEMS
We ve all used ice packs on sprains, strains and stings to alleviate discomfort. Cryotherapy in one form or another has probably existed since early humans first encountered snow and ice. Documents from ancient Egypt report the use of medicinal cold therapy. Battlefield surgeons under Napoleon used cold to anesthetize limbs prior to amputation. Intentional systemic hypothermia or therapeutic hypothermia was first documented in modern times in 1943. Dr. Fay described human refrigeration as a treatment to slow rapidly spreading cancer cells and control pain.
https://www.jems.com/2007/06/25/human-refrigeration/
Silent Killer: How to Prevent, Detect and Treat Hypothermia - American Survival Guide
IDENTIFYING HYPOTHERMIA When it is exposed to cold, the body kicks into action to produce heat. It does this by the use of muscle actions as the core cools. Muscles shiver to produce heat and are a warning that you need to warm up. As hypothermia worsens, more symptoms will become apparent. Aside from shivering, the most noticeable symptoms of hypothermia will be related to mental status. The person might appear confused, uncoordinated and lethargic.. The victims speech becomes slurred, and they often appear uninterested in helping themselves. All this occurs as a result of the effect of cooling temperatures on the brain: The colder the body core gets, the slower the brain works. Other organs begin to shut down, and the victim loses consciousness. Any unconscious person you find exposed to cold weather should be considered hypothermic until proven otherwise.. Cold-related tissue effects also include local damage, such as frostbite. Frostbite affects areas such as the fingers, toes, nose, ...
https://www.asgmag.com/features/silent-killer-how-to-prevent-detect-and-treat-hypothermia/
What is included in medical care for hypoxic-ischemic encephalopathy (HIE)?What is included in medical care for hypoxic-ischemic encephalopathy (HIE)?
Therapeutic hypothermia is indicated for infants with moderate-to-severe hypoxic-ischemic encephalopathy (HIE). Supportive management is also critical to prevent additional injury from seizure activit... more
https://www.medscape.com/answers/973501-106512/1139599-overview
Thermoregulate, autoregulate and ventilate: Brain-directed critical care for pediatric cardiac arrest<...
TY - JOUR. T1 - Thermoregulate, autoregulate and ventilate. T2 - Brain-directed critical care for pediatric cardiac arrest. AU - Kurz, Jonathan. AU - Smith, Craig Martin. AU - Wainwright, Mark. PY - 2017/6/1. Y1 - 2017/6/1. N2 - Purpose of review Cardiac arrest in childhood is associated with a high risk for mortality and poor long-term functional outcome. This review discusses the current evidence for neuroprotective therapies and goals for postarrest care in the context of the pathophysiology of hypoxic-ischemic injury, modalities for neurologic prognostication in these children and potential future monitoring paradigms for maximizing cerebral perfusion in the postarrest period. Recent findings The recent publication of the in-hospital and out-of-hospital Therapeutic Hypothermia After Cardiac Arrest trials demonstrated a lack of statistically significant benefit for the use of postarrest therapeutic hypothermia. As a result, targeted normothermic temperature management has become standard of ...
https://www.scholars.northwestern.edu/en/publications/thermoregulate-autoregulate-and-ventilate-brain-directed-critical
Independent contributions of hypothermia and acidosis to coagulopathy in swine<...Independent contributions of hypothermia and acidosis to coagulopathy in swine<...
TY - JOUR. T1 - Independent contributions of hypothermia and acidosis to coagulopathy in swine. AU - Martini, Wenjun Z.. AU - Pusateri, Anthony E.. AU - Uscilowicz, John M.. AU - Delgado, Angel V.. AU - Holcomb, John B.. AU - Tyburski, James G.. AU - Rhee, Peter M.. AU - Schreiber, Martin A.. PY - 2005/5. Y1 - 2005/5. N2 - Background: Clinical coagulopathy occurs frequently in the presence of acidosis and hypothermia. The purpose of this study was to determine the relative contributions of acidosis and hypothermia to coagulopathy, as measured by current standard bedside and clinical laboratory analyses (i.e., bleeding time and prothrombin time). In addition, we investigated possible mechanisms of these effects using a modified prothrombin time test, thromboelastography, and thrombin kinetics analyses. An improved understanding of coagulopathy should facilitate hemorrhage control. Methods: Twenty-four pigs were randomly allocated into normal (pH, 7.4; 39°C), acidotic (pH, 7.1; 39°C), ...
https://ohsu.pure.elsevier.com/en/publications/independent-contributions-of-hypothermia-and-acidosis-to-coagulop-2
Surgical humidificationSurgical humidification
Bessell, J; Ludbrook G; Millard S; Baxter P; Ubhi S; Maddern G (1999). "Humidified gas prevents hypothermia induced by ... Bessel, J; Karatassas A; Patterson J; Jamieson G; Maddern G (1995). "Hypothermia induced by laparoscopic insufflation. A ... Surgical hypothermia, defined as a core temperature below 36.0 °C, is associated with increased risk of infectious and non- ... Barring preventive interventions, hypothermia occurs in more than half of all surgical patients undergoing anesthesia. The risk ...
https://en.wikipedia.org/wiki/Surgical_humidification
BizarroBizarro
... inducing frostbite and even hypothermia. "Flame breath" allows him to exhale a superheated napalm-like substance which causes ...
https://en.wikipedia.org/wiki/Bizarro
Arctic Sun medical deviceArctic Sun medical device
Non-invasively induced therapeutic hypothermia has been shown to reduce mortality of successfully resuscitated cardiac arrest ... McKean, Staci (2009). "Induced Moderate Hypothermia After Cardiac Arrest". AACN Advanced Critical Care. 20 (4): 342-53. doi: ... It is a non-invasive temperature management system that is used to induce hypothermia in comatose patients that have suffered ... Therapeutic hypothermia, which lowers the patient's body temperature to levels between 32-34 °C (90-93 °F), is used to help ...
https://en.wikipedia.org/wiki/Arctic_Sun_medical_device
Hypothermia capHypothermia cap
Induced pediatric hypothermia was approved in the U.S. by the FDA in March 2007. The most prominent such hypothermia cap which ... Therapeutic hypothermia Hershman, DL (14 February 2017). "Scalp Cooling to Prevent Chemotherapy-Induced Alopecia: The Time Has ... No side effects related to the hypothermia cap were observed. The study concluded that "prehospital use of hypothermia caps is ... A hypothermia cap (also referred to as cold cap or cooling cap) is a therapeutic device used to cool the human scalp. Its most ...
https://en.wikipedia.org/wiki/Hypothermia_cap
Torture in the United StatesTorture in the United States
Inducing hypothermia or heat injury; Conducting mock executions; Depriving the detainee of necessary food, water, sleep, or ... The manuals describe coercive techniques to be used "to induce psychological regression in the subject by bringing a superior ... Lawg.org Archived 2006-04-19 at the Wayback Machine JPRA Operational Concerns Over Application of Various Means of Induced ...
https://en.wikipedia.org/wiki/Torture_in_the_United_States
Peter M. RheePeter M. Rhee
"Induced Hypothermia During Emergency Department Thoracotomy: an Animal Model. Journal of Trauma Injury and Critical Care. 48: ... "Induced Hypothermia During Emergency Department Thoracotomy: an Animal Model". Journal of Trauma Injury and Critical Care. 48: ...
https://en.wikipedia.org/wiki/Peter_M._Rhee
NeurotensinNeurotensin
It induces a variety of effects, including analgesia, hypothermia and increased locomotor activity. It is also involved in ... Neurotensin is an endogenous neuropeptide involved in thermoregulation that can induce hypothermia and neuroprotection in ... "Neurotensin-induced hypothermia improves neurologic outcome after hypoxic-ischemia". Crit. Care Med. 32 (3): 806-10. doi: ...
https://en.wikipedia.org/wiki/Neurotensin
Andrew CappuccinoAndrew Cappuccino
Cappuccino's use of induced hypothermia garnered national headlines for the technique. Cappuccino received a dual BES degree ... "Acuity Care Technology - Article - Induced Hypothermia Shows Promise in Treating Cardiac, Neurotrauma Patients". Retrieved 2008 ...
https://en.wikipedia.org/wiki/Andrew_Cappuccino
Battlefield medicineBattlefield medicine
As trauma-induced hypothermia is a leading cause of battlefield deaths, a provider may also perform hypothermia prevention can ... Bennett BL, Holcomb JB (June 2017). "Battlefield Trauma-Induced Hypothermia: Transitioning the Preferred Method of Casualty ... Since hypothermia can occur regardless of ambient temperature due to blood loss, the Hypothermia Prevention and Management Kit ... Head injury/hypothermia. Secondary brain injury is worsened by hypotension (systolic blood pressure under 90 mmHg), hypoxia ( ...
https://en.wikipedia.org/wiki/Battlefield_medicine
Targeted temperature managementTargeted temperature management
Hypothermia induces a "cold diuresis" which can lead to electrolyte abnormalities - specifically hypokalemia, hypomagnesaemia, ... It appears that regardless of the technique used to induce hypothermia, people begin to shiver when temperature drops below ... There are a number of methods through which hypothermia is induced. These include: cooling catheters, cooling blankets, and ... Polderman, Kees H (2008). "Induced hypothermia and fever control for prevention and treatment of neurological injuries". The ...
https://en.wikipedia.org/wiki/Targeted_temperature_management
Hunting reactionHunting reaction
Hypothermia Thermoregulation Axon reflex Raynaud's syndrome Daanen, H.A.M. (2003). "Finger cold-induced vasodilation: a review ... This cold-induced vasodilation increases blood flow and subsequently the temperature of the fingers. A new phase of ...
https://en.wikipedia.org/wiki/Hunting_reaction
Lance BeckerLance Becker
Bushak, Lecia (December 20, 2014). "Induced Hypothermia: How Freezing People After Heart Attacks Could Save Lives". Newsweek. ... "profound hypothermia" is then medically induced, at temperatures as low as 50 F (10 C). According to Becker, "draining the ... Cell death can be delayed or stopped through the application of therapeutic hypothermia. In the case of Swedish skier Anna ...
https://en.wikipedia.org/wiki/Lance_Becker
Skin temperatureSkin temperature
It is important to note that induced mild hypothermia, between temperatures of 33 °C and 36 °C is effective whilst safer than ... Council, National Research (1955). Physiology of Induced Hypothermia: Proceedings of a Symposium, 28-29 October 1955. doi: ... Hypothermia also has a significant therapeutic role, the technique of therapeutic hypothermia involves deliberate reduction of ... Hypothermia is defined as having a core body temperature below 35 °C (or 95 °F). Under 35 °C, the body loses more heat than it ...
https://en.wikipedia.org/wiki/Skin_temperature
Clinical deathClinical death
This induced hypothermia technique is beginning to be used in emergency medicine. The combination of mildly reducing body ... 1990). "Moderate hypothermia after cardiac arrest of 17 minutes in dogs. Effect on cerebral and cardiac outcome". Stroke. ... 1990). "Mild cerebral hypothermia during and after cardiac arrest improves neurologic outcome in dogs". Journal of Cerebral ... 1990). "Accidental deep hypothermia with cardiopulmonary arrest: extracorporeal blood rewarming in 11 patients". European ...
https://en.wikipedia.org/wiki/Clinical_death
Delta-sleep-inducing peptideDelta-sleep-inducing peptide
May have a direct or indirect effect on body temperature and alleviating hypothermia. Can normalize blood pressure and ... "The effects of Delta Sleep-Inducing Peptide on incidence and severity in metaphit-induced epilepsy in rats". Pharmacological ... Delta-sleep-inducing peptide was first discovered in 1974 by the Swiss Schoenenberger-Monnier group who isolated it from the ... Gimble JM, Ptitsyn AA, Goh BC, Hebert T, Yu G, Wu X, Zvonic S, Shi XM, Floyd ZE (2009). "Delta sleep-inducing peptide and ...
https://en.wikipedia.org/wiki/Delta-sleep-inducing_peptide
Hypovolemic shockHypovolemic shock
Trauma-induced coagulopathy is acutely worsened by the presence of acidosis and hypothermia. The activity of coagulation ... Hypothermia (less than 34 C) compounds coagulopathy by impairing coagulation and is an independent risk factor for death in ... However, this traditional model of trauma-induced coagulopathy may be too limited. Further studies have shown that a degree of ... This has led to the recognition of trauma-induced coagulopathy as the sum of two distinct processes: acute coagulopathy of ...
https://en.wikipedia.org/wiki/Hypovolemic_shock
IodoresiniferatoxinIodoresiniferatoxin
In mice, I-RTX induces dose-dependent hypothermia in vivo. A statistically significant difference was reported at doses > 0.1 ... "5-Iodoresiniferatoxin evokes hypothermia in mice and is a partial transient receptor potential vanilloid 1 agonist in vitro". ...
https://en.wikipedia.org/wiki/Iodoresiniferatoxin
Emergency Preservation and ResuscitationEmergency Preservation and Resuscitation
... in that hypothermia is induced. However, the purposes and procedures of EPR differ from DHCA. DHCA induces hypothermia to aid ... The trial procedure involves rapidly inducing profound hypothermia (10 °C) with an aortic flush in trauma victims that have ... EPR uses hypothermia, drugs, and fluids to "buy time" for resuscitative surgery. If successful, EPR may someday be deployed in ... Twilley, Nicola (21 November 2016). "Can Hypothermia Save Gunshot Victims?". The New Yorker. Retrieved 23 January 2018. Kaplan ...
https://en.wikipedia.org/wiki/Emergency_Preservation_and_Resuscitation
Hypothermia therapy for neonatal encephalopathyHypothermia therapy for neonatal encephalopathy
Mild total body hypothermia, induced by cooling a baby to 33-34°C for three days after birth, is nowadays a standardized ... Many of the effects induced by mild hypothermia may help to reduce the number of cells undergoing apoptosis. Experimental and ... Busto R, Globus MY, Dietrich WD, Martinez E, Valdés I, Ginsberg MD (July 1989). "Effect of mild hypothermia on ischemia-induced ... Hypothermia appears to have multiple effects at a cellular level following cerebral injury. Hypothermia reduces vasogenic ...
https://en.wikipedia.org/wiki/Hypothermia_therapy_for_neonatal_encephalopathy
Pain in amphibiansPain in amphibians
"Evaluation of hypothermia-induced analgesia and influence of opioid antagonists in Leopard frogs (Rana pipiens)". Pharmacology ... "The role of pH and osmolarity in evoking the acetic acid-induced wiping response in a model of nociception in frogs". Brain ... "Hypothermia is also unacceptable as a sedation technique for painful procedures". Veterinary articles have been published ...
https://en.wikipedia.org/wiki/Pain_in_amphibians
HypothermiaHypothermia
Many animals other than humans often induce hypothermia during hibernation or torpor.[citation needed] Water bears (Tardigrade ... Hypoglycemia is also found in many people with hypothermia, as hypothermia may be a result of hypoglycemia. As hypothermia ... People with hypothermia may appear pale and feel cold to touch. Infants with hypothermia may feel cold when touched, with ... Hypothermia occurs frequently in major trauma, and is also observed in severe cases of anorexia nervosa. Hypothermia is also ...
https://en.wikipedia.org/wiki/Hypothermia
Glossary of underwater diving terminology: H-OGlossary of underwater diving terminology: H-O
hypothermia A lowering of core body temperature, usually due to heat loss. hypoxia Abnormally low tissue oxygen concentration: ... hyperventilation-induced blackout See: underwater blackout syndrome hypocapnia Abnormally low tissue and blood carbon dioxide ...
https://en.wikipedia.org/wiki/Glossary_of_underwater_diving_terminology:_H–O
Intravenous therapyIntravenous therapy
If the solutions administered are colder than the temperature of the body, induced hypothermia can occur. If the temperature ... "Warming of intravenous and irrigation fluids for preventing inadvertent perioperative hypothermia". Cochrane Database of ...
https://en.wikipedia.org/wiki/Intravenous_therapy
Nectar DesignNectar Design
Collaborated with medical manufacturer Benechill on its new Rhinochill system, which induces therapeutic hypothermia during ...
https://en.wikipedia.org/wiki/Nectar_Design
CheetahCheetah
... s are induced ovulators and can breed throughout the year. Females can have their first litter at two to three years of ... Deaths result from several reasons-stillbirths, birth defects, cannibalism, hypothermia, maternal neglect, and infectious ... Compared to other felids, cheetahs need specialised care because of their higher vulnerability to stress-induced diseases; this ...
https://en.wikipedia.org/wiki/Cheetah
TalsupramTalsupram
... on apomorphine-induced hypothermia in mice". Psychopharmacology. 88 (2): 240-6. doi:10.1007/BF00652248. PMID 3006113. S2CID ...
https://en.wikipedia.org/wiki/Talsupram
Cerebral edemaCerebral edema
In traumatic brain injury, induced hypothermia may reduce the risks of mortality, poor neurologic outcome in adults. However, ... Radiation-induced brain edema (RIBE) is a potentially life threatening complication of brain tissue radiation and is ... In children with traumatic brain injury, there was no benefit to therapeutic hypothermia and increased the risk of mortality ... Pretreatment with a sedative agent and neuromuscular blocking agent to induce unconsciousness and motor paralysis has been ...
https://en.wikipedia.org/wiki/Cerebral_edema
SynephrineSynephrine
Reversal of reserpine-induced hypothermia by a drug is a classical test for potential anti-depressant properties. A selective ... In mice pre-treated with reserpine, an oral dose of 0.3 mg/kg d-synephrine significantly reversed the hypothermia, while l- ... Barrett M., Orchard I. (1990). "Serotonin-induced elevation of cAMP levels in the epidermis of the blood-sucking bug, Rhodnius ... Synephrine (racemic) is also more potent than octopamine (racemic) at inducing light-emission in the firefly (Photinus species ...
https://en.wikipedia.org/wiki/Synephrine
Deep hypothermic circulatory arrestDeep hypothermic circulatory arrest
... in a case of accidental hypothermia(40) and 9°C (48°F) in a case of induced hypothermia.(58)... 58. Niazi SA, Lewis FJ. ... Although reports of the use of CPB-induced hypothermia and DHCA to facilitate aortic arch surgery appeared in the 1960s, it was ... Deep hypothermic circulatory arrest (DHCA) is a surgical technique that induces deep medical hypothermia. It involves cooling ... Mild hypothermia (32 °C to 34 °C) and moderate hypothermia (26 °C to 31 °C) are contraindicated for hypothermic circulatory ...
https://en.wikipedia.org/wiki/Deep_hypothermic_circulatory_arrest
AMG-517AMG-517
November 2017). "Transient Receptor Potential Vanilloid 1 Antagonists Prevent Anesthesia-induced Hypothermia and Decrease ...
https://en.wikipedia.org/wiki/AMG-517
Brain ischemiaBrain ischemia
Seizures can induce more damage; accordingly, anticonvulsants should be prescribed and should a seizure occur, aggressive ... Evidence supporting the use of therapeutic hypothermia after brain ischemia, however, is limited.[citation needed] A closely ... In 1974, Hossmann and Zimmermann demonstrated that ischemia induced in mammalian brains for up to an hour can be at least ... Therapeutic hypothermia has been attempted to improve results post brain ischemia[citation needed]. This procedure was ...
https://en.wikipedia.org/wiki/Brain_ischemia
ChildbirthChildbirth
Induced births and elective cesarean before 39 weeks can be harmful to the neonate as well as harmful or without benefit to the ... Lunze K, Bloom DE, Jamison DT, Hamer DH (January 2013). "The global burden of neonatal hypothermia: systematic review of a ... Induced labor is indicated for postterm pregnancy. Newborns are prone to infection in the first month of life. The pathogenic ... Inducing labour can be accomplished with pharmaceutical or non-pharmaceutical methods. Inductions are most often performed ...
https://en.wikipedia.org/wiki/Childbirth
Shimazaki MasakiShimazaki Masaki
By late 1886 he had died from beriberi induced heart failure. Contrary to his wishes, he was buried in the Buddhist cemetery of ... Thereafter he became increasingly deranged while his health rapidly declined due to starvation, hypothermia, and exposure to ...
https://en.wikipedia.org/wiki/Shimazaki_Masaki
N-Arachidonoyl dopamineN-Arachidonoyl dopamine
In mice, NADA was shown to induce the tetrad of physiological paradigms associated with cannabinoids: hypothermia, hypo- ... However, the indirect biosynthesis of phospholipid esters with dopamine may be possible, as dopamine can induce the aminolysis ... "Endogenous N-acyl-dopamines induce COX-2 expression in brain endothelial cells by stabilizing mRNA through a p38 dependent ...
https://en.wikipedia.org/wiki/N-Arachidonoyl_dopamine
LevothyroxineLevothyroxine
... which is a severe form of hypothyroidism characterized by mental status changes and hypothermia. As it is a medical emergency ... which is considered goiter-inducing. Levothyroxine is also used as interventional therapy in people with nodular thyroid ...
https://en.wikipedia.org/wiki/Levothyroxine
Sympathoadrenal systemSympathoadrenal system
Hypothermia and neurological deficits can also occur. Permanent brain damage is uncommon but have been seen in some who suffer ... The stress induced during exercise results in an increase in the hormones, epinephrine and norepinephrine, which are known for ... Hypertension also causes an increase in catecholamine release during experiments of stress-induced situations. While ...
https://en.wikipedia.org/wiki/Sympathoadrenal_system
Paul WyliePaul Wylie
Wylie was put into a medically induced coma and began a treatment known as therapeutic hypothermia in order to cool his brain ...
https://en.wikipedia.org/wiki/Paul_Wylie
Animal psychopathologyAnimal psychopathology
Pica may be induced by these social stressors. Other theories contemplated include pica as a redirection of prey-catching/ ... They experience emaciation, hypothermia, a depraved appetite, restlessness, and hyperactivity. The syndrome may mainly be ... Rats were induced to intake kaolin by administering various emetic stimuli such as copper sulfate, apomorphine, cisplatin, and ... Connie reported that stresses particularly likely to induce pawing included being unable to find her and sensing that he was ...
https://en.wikipedia.org/wiki/Animal_psychopathology
Mother BrookMother Brook
He was in a medically induced coma, but died four days later. Others have been more fortunate, and were able to be rescued. ... He was brought to Norwood Hospital with hypothermia and was later released. Two boys claimed to have found a human leg in the ...
https://en.wikipedia.org/wiki/Mother_Brook
MooseMoose
Loss of the insulating winter coat through attempts to rid the moose of winter tick increases the risk of hypothermia in winter ... Studies suggest that the calls made by female moose during the rut not only call the males but can actually induce a bull to ... has resulted in milder winters that induce favorable conditions for ticks, parasites and other invasive species to flourish ... of their range is increasing heat stress brought on by the rapid seasonal temperature upswings as a result of human-induced ...
https://en.wikipedia.org/wiki/Moose
JTC-801JTC-801
October 2002). "Characterization of nociceptin/orphanin FQ-induced pain responses by the novel receptor antagonist N-(4-amino-2 ... blocks cannabinoid-evoked hypothermia in rats". Neuropeptides. 41 (4): 239-47. doi:10.1016/j.npep.2007.03.001. PMID 17512052. ... "The opioid peptide nociceptin/orphanin FQ mediates prostaglandin E2-induced allodynia, tactile pain associated with nerve ...
https://en.wikipedia.org/wiki/JTC-801
Erika NordbyErika Nordby
Gilbert M, Busund R, Skagseth A, Nilsen P, Solbo J (2000). "Resuscitation from accidental hypothermia of 13.7 °C with ... "Hutchinson Center Researchers First to Induce State of Suspended Animation in Model Vertebrate Organism". Fred Hutchinson ... hypothermia was 13.7 °C (56.7 °F). Erika's heart resumed beating after she was placed under a warming blanket. Doctors ... Alberta known for having been revived after spending two hours without a heartbeat due to hypothermia. Nordby, then a 13-month- ...
https://en.wikipedia.org/wiki/Erika_Nordby
Spinal cord injurySpinal cord injury
Patients are taught to increase their intra-abdominal pressure by leaning forward to induce cough and clear mild secretions. ... Research into potential treatments includes stem cell implantation, hypothermia, engineered materials for tissue support, ... and induced pluripotent stem cells. Hundreds of stem cell studies have been done in humans, with promising but inconclusive ...
https://en.wikipedia.org/wiki/Spinal_cord_injury
Benzodiazepine overdoseBenzodiazepine overdose
Perry HE, Shannon MW (June 1996). "Diagnosis and management of opioid- and benzodiazepine-induced comatose overdose in children ... hypothermia, hypotension, bradycardia, cardiac arrest, and pulmonary aspiration, with the possibility of death. Severe ...
https://en.wikipedia.org/wiki/Benzodiazepine_overdose
Head injuryHead injury
Neurotoxicity is another cause of brain damage that typically refers to selective, chemically induced neuron/brain damage. Head ... found a net 65% favorable outcomes rate in pediatric patients), barbiturate coma, hypertonic saline, and hypothermia. Although ...
https://en.wikipedia.org/wiki/Head_injury
Saturation divingSaturation diving
To prevent hypothermia, hot-water suits are commonly used for saturation diving, and the breathing gas supply may be heated. ... These parameters induce changes in the vocal tract formants, which affect the timbre, and a slight change of pitch. Several ... It has been hypothesised that his survival may have been a result of hypothermia, high partial pressure of oxygen in the ... may rapidly lose body heat and suffer from hypothermia, which is unhealthy, can be life-threatening, and reduces diver ...
https://en.wikipedia.org/wiki/Saturation_diving
Temperature playTemperature play
The risks of cold exposure are hypothermia and frostbite. Common methods of heat torture are to wrap a subject in plastic wrap ... General heat and cold exposure may be used as foreplay where during which intercourse occurs or orgasm is induced. Alternative ... longer periods of time run the risk of hypothermia and frostbite). Ice may be used to provide contrast in a scene that also ...
https://en.wikipedia.org/wiki/Temperature_play
Armero tragedyArmero tragedy
Mud moved into open wounds and other open body parts - the eyes, ears, and mouth - and placed pressure capable of inducing ... or contracted hypothermia, though the latter is unlikely, given that survivors described the water as warm. Another lahar, ... volcanically induced mudflows, landslides, and debris flows) down its slopes at 50 km/h (30 mph). The lahars picked up speed in ... and she succumbed to gangrene and hypothermia after sixty hours of being trapped. Her death epitomized the tragic nature of the ...
https://en.wikipedia.org/wiki/Armero_tragedy
MethylenedioxypyrovaleroneMethylenedioxypyrovalerone
The official cause of death of both men was hypothermia, but toxicology reports later confirmed that both Troy Johnson, 29, and ... It has also been repeatedly noted to induce irresistible cravings to re-administer. Reported modalities of intake include oral ... Physicians often treat MDPV overdose cases with anxiolytics, such as benzodiazepines, to lessen the drug-induced activity in ...
https://en.wikipedia.org/wiki/Methylenedioxypyrovalerone
Infant swimmingInfant swimming
There may be a link between infant swimming and rhinovirus-induced wheezing illnesses. Others have indicated concerns that the ... hypothermia, hyponatremia, infectious illness, and lung damage from pool chemicals). The American Centers for Disease Control ... or that the infant could experience hypothermia, suffer from water intoxication after swallowing water, or develop ... "Association between infant swimming and rhinovirus-induced wheezing". Acta Paediatrica. 103 (11): 1153-1158. doi:10.1111/apa. ...
https://en.wikipedia.org/wiki/Infant_swimming
NeuroprotectionNeuroprotection
Caffeine induces neuronal glutathione synthesis by promoting cysteine uptake, leading to neuroprotection. When applied to ... Sinclair HL, Andrews PJ (2010). "Bench-to-bedside review: Hypothermia in traumatic brain injury". Crit Care. 14 (1): 204. doi: ... Herrera-Mundo N, Sitges M (2013). "Vinpocetine and α-tocopherol prevent the increase in DA and oxidative stress induced by 3- ... Zheng YQ, Liu JX, Wang JN, Xu L (2006). "Effects of crocin on reperfusion-induced oxidative/nitrative injury to cerebral ...
https://en.wikipedia.org/wiki/Neuroprotection
DesiccantDesiccant
... s induce dryness in any environment and reduce the amount of moisture present in air. Desiccants come in various forms ... Desiccants are used in livestock farming, where, for example, new-born piglets are highly susceptible to hypothermia owing to ... A desiccant is a hygroscopic substance that is used to induce or sustain a state of dryness (desiccation) in its vicinity; it ...
https://en.wikipedia.org/wiki/Desiccant
VasospasmVasospasm
After the hypothermia rewarming period, the patient died from increased intracranial pressure and anisocoria. A sample of the ... It does not stimulate as much prostacyclin and NO to induce relaxation on smooth muscle cells. Also there is not as much ... These drugs work by increasing nitric oxide levels in the blood and inducing coronary vasodilation which will allow for more ... In a case study in 2000, following surgery for head trauma, a patient developed mild hypothermia, a typical defense mechanism ...
https://en.wikipedia.org/wiki/Vasospasm
List of Wild Cards charactersList of Wild Cards characters
No Dice, a drug dealing "gangsta" that employed Shad's ability to absorb heat and induce hypothermia to eliminate his ... In Croyd's case, however, his mutation induces the virus to periodically re-infect his body (similar to malaria), causing him ... and can incapacitate his foes with hypothermia. Shadow can use the absorbed energy to boost his strength and speed to ...
https://en.wikipedia.org/wiki/List_of_Wild_Cards_characters
Perinatal strokePerinatal stroke
Therapeutic hypothermia is a process that reduces the metabolism and induces self-repairing of the brain by cooling it down. ... A new direction in treating perinatal stroke by combining therapeutic hypothermia and growth factor medications will most ... This disease can be treated by anticoagulant and anticonvulsant drugs, surgical procedures, and therapeutic hypothermia, ... while surgery and therapeutic hypothermia will be required to treat hemorrhagic stroke during the perinatal stage. ...
https://en.wikipedia.org/wiki/Perinatal_stroke
Eurasian eagle-owlEurasian eagle-owl
Martinez, J. A.; Martinez, J. E.; Manosa, S.; Zuberogoitia, I. & Calvo, J. F. (2006). "How to manage human-induced mortality in ... fledgling success because it inhibited the ability of the parents to hunt and potentially exposed nestlings to hypothermia. In ...
https://en.wikipedia.org/wiki/Eurasian_eagle-owl
CannabinoidCannabinoid
It is approved by the FDA for treating HIV/AIDS induced anorexia and chemotherapy induced nausea and vomiting. The CBD drug ... It binds to the CB1 cannabinoid receptor (Ki = 21.2 nmol/L) and causes sedation, hypothermia, intestinal immobility, and mild ... Badowski ME (September 2017). "A review of oral cannabinoids and medical marijuana for the treatment of chemotherapy-induced ... induce anandamide and 2-arachidonoylglycerol synthesis produced naturally in the body and brain[citation needed][dubious - ...
https://en.wikipedia.org/wiki/Cannabinoid
Seattle & King County Emergency Medical Services SystemSeattle & King County Emergency Medical Services System
Emergency Medical Technician Treatment of Hypoglycemia in the Field Induced Hypothermia for Cardiac Arrest Patients ...
https://en.wikipedia.org/wiki/Seattle_&_King_County_Emergency_Medical_Services_System
Language: English / Format: Text / Subject: Hypothermia, Induced / Story Section: The Cold Heart: Hypothermia and Cardiac...Language: English / Format: Text / Subject: Hypothermia, Induced / Story Section: The Cold Heart: Hypothermia and Cardiac...
Hypothermia, Induced ✖ Remove constraint Subject: Hypothermia, Induced Story Section The Cold Heart: Hypothermia and Cardiac ... 1. Hypothermia for General and Cardiac Surgery: With Techniques of Some Open Intracardiac Procedures Under Hypothermia Date: ... 3. Surgery by Direct Vision in the Open Heart during Hypothermia Date: 21 November 1953 ... 5. The Current Status of Hypothermia in Cardiovascular Surgery Date: November 1961 ...
https://profiles.nlm.nih.gov/spotlight/hp/catalog?f%5Breadonly_format_ssim%5D%5B%5D=Text&f%5Breadonly_language_ssim%5D%5B%5D=English&f%5Breadonly_story-section_ssim%5D%5B%5D=The+Cold+Heart%3A+Hypothermia+and+Cardiac+Surgery%2C+1949-1962&f%5Breadonly_subject_ssim%5D%5B%5D=Hypothermia%2C+Induced&per_page=50&search_field=all_fields&sort=readonly_title_ssim+asc&view=gallery
Browsing Biological and Environmental Engineering by Subject induced hypothermiaBrowsing Biological and Environmental Engineering by Subject "induced hypothermia"
Modeling the Effects of Induced Hypothermia for the Treatment of a Cervical Spinal Cord Injury  Bruhn, Tim; Karabayinga, ... Browsing Biological and Environmental Engineering by Subject "induced hypothermia". 0-9. A. B. C. D. E. F. G. H. I. J. K. L. M ...
https://ecommons.cornell.edu/handle/1813/323/browse?type=subject&value=induced+hypothermia
Subject: Hypothermia, Induced / Genre: 3 selected - Henry Swan - Profiles in Science Search ResultsSubject: Hypothermia, Induced / Genre: 3 selected - Henry Swan - Profiles in Science Search Results
Nitric oxide-mediated inhibition of phenylephrine-induced contraction in response to hypothermia is partially modulated by...Nitric oxide-mediated inhibition of phenylephrine-induced contraction in response to hypothermia is partially modulated by...
The results suggest that hypothermia-induced, NO-dependent inhibition of phenylephrine-induced contraction is mediated by ... and endothelial Rho-kinase membrane translocation induced by phenylephrine. Mild hypothermia attenuated phenylephrine-induced ... Y-27632 and L-NAME attenuated the enhancing effect of hypothermia on phenylephrine-induced endothelial Rho-kinase membrane ... Nitric oxide-mediated inhibition of phenylephrine-induced contraction in response to hypothermia is partially modulated by ...
https://medsci.org/v17p0021
Therapeutic hypothermia can be induced and maintained using either commercial water bottles or a phase changing material...Therapeutic hypothermia can be induced and maintained using either commercial water bottles or a "phase changing material"...
Therapeutic hypothermia can be induced and maintained using either commercial water bottles or a "phase changing material" ... Therapeutic hypothermia can be induced and maintained using either commercial water bottles or a "phase changing material" ... Conclusion: Simple, low-tech cooling devices can induce and maintain therapeutic hypothermia effectively in a porcine model of ... Results: Therapeutic hypothermia was achieved with both water bottles (n = 5) and the PCM mattress (n = 6). The mean (SD) time ...
https://adc.bmj.com/content/94/5/387
Hypothermia-Related Deaths - Wisconsin, 2014, and United States, 2003-2013Hypothermia-Related Deaths - Wisconsin, 2014, and United States, 2003-2013
Environmental cold-induced injury. Surg Clin North Am 2007;87:247-67,viii. ... Rate* of hypothermia-related deaths,† by sex and age group - United States, 2003-2013 ... Educational materials should emphasize the rapidity with which hypothermia can occur, review the warning signs of hypothermia, ... the Wisconsin Division of Public Health began active surveillance for hypothermia. Suspected hypothermia-related deaths were ...
https://www.cdc.gov/mmwr/preview/mmwrhtml/mm6406a2.htm?s_cid=mm6406a2_w
IMSEAR at SEARO: Induced mild hypothermia in post-cardiopulmonary bypass vasoplegia syndrome.
Induced mild hypothermia in post-cardiopulmonary bypass vasoplegia syndrome.. Authors: Tripathi, Mukesh. Singh, Prabhat Kumar. ... Induced mild hypothermia in post-cardiopulmonary bypass vasoplegia syndrome. Annals of Cardiac Anaesthesia. 2009 Jan-Jun; 12(1 ... We could successfully use induced mild hypothermia to increase SVR, and could avoid very high doses of nor-epinephrine (,0.3 ...
https://imsear.searo.who.int/handle/123456789/1639
Hypothermia Clinical Presentation: History, Physical Examination, ComplicationsHypothermia Clinical Presentation: History, Physical Examination, Complications
Hypothermia is classified as accidental or intentional, primary or secondary, and by the degree of hypothermia. ... Hypothermia describes a state in which the bodys mechanism for temperature regulation is overwhelmed in the face of a cold ... Survival after avalanche-induced cardiac arrest. Resuscitation. 2014 Sep. 85(9):1192-6. [QxMD MEDLINE Link]. ... encoded search term (Hypothermia) and Hypothermia What to Read Next on Medscape ...
https://emedicine.medscape.com/article/770542-clinical
INDUCED HYPOTHERMIA - the nursing role - SepINDUCED HYPOTHERMIA - the nursing role - Sep
The era of mild induced hypothermia in the University Medical Center Ljubljana begun in 2003.. AIM: The aim is to develop ... Hypothermia was induced in 68%. 57% of patients survived and majority survived with good neurological outcome (cerebral ... Ključne riječi: Hypothermia , cardiac arest, acute myocardial infarction Kongres/Simpozij: "5. Međunarodni kongres HDMSARIST-a ... nursing profession and standards for induced hypothermia, ensuring quality holistic nursing care and best teams.. Results: ...
https://sep.hr/induced-hypothermia-the-nursing-role/
Potential mechanisms of hypothermia-induced electrolyte depletion [1] (multiple letters)<...
Potential mechanisms of hypothermia-induced electrolyte depletion [1] (multiple letters). Kees H. Polderman*, Armand R.J. ... Potential mechanisms of hypothermia-induced electrolyte depletion [1] (multiple letters). Critical Care Medicine. 2002 Aug 24; ... Potential mechanisms of hypothermia-induced electrolyte depletion [1] (multiple letters). / Polderman, Kees H.; Girbes, Armand ... Polderman, K. H., & Girbes, A. R. J. (2002). Potential mechanisms of hypothermia-induced electrolyte depletion [1] (multiple ...
https://research.vumc.nl/en/publications/potential-mechanisms-of-hypothermia-induced-electrolyte-depletion
Food Protein-Induced Enterocolitis SyndromeFood Protein-Induced Enterocolitis Syndrome
... is an allergic disease with expression predominantly in the GI tract. Whats the ... Box 1. Clues in favor of a specific IgE role in food protein-induced enterocolitis syndrome pathogenesis. *. There are some ... Food Protein-Induced Enterocolitis Syndrome. From Practice to Theory. Stefano Miceli Sopo; Monica Greco; Serena Monaco; ... Hypothermia (rare). Hypotension (rare). Tables. Table 2. Diagnostic criteria of FPIES. Powell, 19862 Leonard et al., 20121 ...
https://www.medscape.com/viewarticle/810221_3
White Phosphorus: Systemic Agent | NIOSH | CDCWhite Phosphorus: Systemic Agent | NIOSH | CDC
The use of cold water has the potential to induce hypothermia. Take steps to guard against hypothermia. Place particles of ... Do not induce vomiting (emesis).. *Monitor heart function. Evaluate for low blood pressure (hypotension), abnormal heart ... The use of cold water is critical, but be careful to guard the patient/victim against hypothermia. ... Proton-induced X-ray emission analysis of munitions disposal residues. Nuclear Instruments and Methods in Physics Research ...
https://www.cdc.gov/niosh/ershdb/emergencyresponsecard_29750025.html
Therapeutic Essay | BartlebyTherapeutic Essay | Bartleby
The Effects Of Induced Therapeutic Hypothermia On Cardiac Arrest Survivors. The American Heart Association (2011) states that ... The Effects Of Induced Therapeutic Hypothermia On Cardiac Arrest Survivors. *1501 Words ... Therapeutic Hypothermia: Preventing Damage After Cardiac Arrest. present some of the notable research that has been done on ... Therapeutic hypothermia is the only intervention demonstrated to improve neurologic recovery after cardiac arrest (Pp 77). ...
https://www.bartleby.com/topics/Therapeutic-Essay
CIA chiefs emails exposed: Key things we learned from WikiLeaks Brennan dump - RT USA NewsCIA chief's emails exposed: Key things we learned from WikiLeaks' Brennan dump - RT USA News
... inducing hypothermia; conducting mock executions; and depriving detainees of food, water, or medical care. ...
https://www.rt.com/usa/319324-cia-brennan-emails-exposed-wikileaks/
Novel Real-time Prediction of Liver Graft Function During Hypothermic Oxygenated Machine Perfusion Before Liver TransplantationNovel Real-time Prediction of Liver Graft Function During Hypothermic Oxygenated Machine Perfusion Before Liver Transplantation
Hypothermia, Induced / methods* * Kaplan-Meier Estimate * Liver Transplantation / adverse effects * Liver Transplantation / ...
https://pubmed.ncbi.nlm.nih.gov/31592808/
Phosphine | Medical Management Guidelines | Toxic Substance Portal | ATSDR
If phosphides have been ingested, do not induce emesis. If it has not been given previously and the patient is alert and able ... Use caution to avoid hypothermia when decontaminating children or the elderly. Use blankets or warmers when appropriate. ... In cases of phosphide ingestion, do not induce emesis. If activated charcoal has not been given previously, administer a slurry ... If phosphides have been ingested, do not induce emesis. Phosphides will release phosphine in the stomach; therefore, watch for ...
https://wwwn.cdc.gov/TSP/MMG/MMGDetails.aspx?mmgid=1013&toxid=214
Neuroprotective Effects of Pharmacological Hypothermia on Glucose Metabolism in Ischemic Rats | Research SquareNeuroprotective Effects of Pharmacological Hypothermia on Glucose Metabolism in Ischemic Rats | Research Square
Pharmacological hypothermia (PH) is a potential neuroprotective strategy for stroke in which the temperature can be decreased ... Although it induces systemic hypothermia, pharmacological hypothermia (PH) is a strong stroke therapy candidate that may be ... Effect of NOX On The Neuroprotection Induced By Pharmacological Hypothermia. To further explore whether PH induced ... Pharmacological hypothermia (PH) is an alternative to physically induced hypothermia, in which the temperature is carefully ...
https://www.researchsquare.com/article/rs-1030512/v1
Search - NeL.eduSearch - NeL.edu
FGF21 is dispensable for hypothermia induced by fasting in mice.. Oishi K, Sakamoto K, Konishi M, Murata Y, Itoh N, Sei H. ... OBJECTIVES: We examined whether FGF21 is essential for fasting-induced hypothermia using FGF21 knockout (KO) mice.. RESULTS: ... Oishi K, Sakamoto K, Konishi M, Murata Y, Itoh N, Sei H. FGF21 is dispensable for hypothermia induced by fasting in mice. Neuro ... On the other hand, a deficiency of FGF21 significantly attenuated chronic hypothermia and hypoactivity induced by a ketogenic ...
https://www.nel.edu/journal/search/?keywords=Pepti&vp-page=3
Ketogenic diet induces skeletal muscle atrophy via reducing muscle protein synthesis and possibly activating proteolysis in...Ketogenic diet induces skeletal muscle atrophy via reducing muscle protein synthesis and possibly activating proteolysis in...
We fed mice with a KD for seven days to assess the underlying mechanisms of muscle wasting induced by chronic starvation. This ... Feeding mice with a KD is a novel experimental animal model of muscle-wasting induced by chronic starvation. ... oxidative stress might also be involved in KD-induced muscle atrophy. ... FGF21 is dispensable for hypothermia induced by fasting in mice. Neuro Endocrinol. Lett. 31, 198-202 (2010). ...
https://www.nature.com/articles/s41598-019-56166-8?error=cookies_not_supported&code=3c4dde44-ca39-4ead-94e2-6108c74ea0f6
Cooling ItCooling It
This technique can induce mild hypothermia in as little as an hour and prevents shivering because the skin is not cooled. ... Writing in the journal Surgery in 1958, he complained that inducing hypothermia with cold packs or ice baths was too slow. ... Part of the problem was the imprecision of techniques for inducing hypothermia, as well as the dangers of deep cooling. In ... Developed by Radiant Medical, this is a new approach to induced hypothermia. Courtesy of Radiant Medical, Inc.. Kenneth Hayes ...
https://www.dana.org/article/cooling-it/
Hypothermia-Related Deaths -- Vermont, October 1994-February 1996Hypothermia-Related Deaths -- Vermont, October 1994-February 1996
Neuroleptic drugs also predispose a person to hypothermia by inducing vasodilation and suppressing the shivering response. The ... Annual death rate associated with hypothermia, by age group .... Article. Hypothermia is a lowering of the core body ... Hypothermia-related deaths -- North Carolina, November 1993-March 1994. MMWR 1994;43:849,855-6. * CDC. Hypothermia-related ... age-adjusted death rate for hypothermia of 0.3 per 100,000 (3). Elderly persons particularly are at risk for hypothermia ...
https://wonder.cdc.gov/wonder/prevguid/m0044869/m0044869.asp
Critical Care | 23rd international symposium on intensive care and emergency medicineCritical Care | 23rd international symposium on intensive care and emergency medicine
The metabolic effect of induced mild hypothermia in critically ill patients Authors: M Bitzani, G Vassiliadou, C Iasonidou, S ... Hypercapnia attenuates the endotoxin-induced tissue metabolic acidosis in esophageal mucosa Authors: M Ponichter, H Billert and ... Treatment of adults with sepsis-induced coagulopathy and purpura fulminans with a plasma-derived protein C concentrate ( ... Determination of functional states during sepsis-induced activation of the hypothalamic-pituitary-adrenal (HPA) axis using ...
https://ccforum.biomedcentral.com/articles/supplements/volume-7-supplement-2
Peripherally administered orexin improves survival of mice with endotoxin shock | eLifePeripherally administered orexin improves survival of mice with endotoxin shock | eLife
OXA ameliorated hypothermia induced by LPS at 4 hr and 22 hr after LPS injection (Figure 2-figure supplement 1). Particularly, ... LPS-induced model of endotoxin shock in mice. Request a detailed protocol To induce the endotoxin shock, mice were ... ICV administered OXA simultaneously ameliorated hypothermia induced by LPS (Figure 4-figure supplement 1). These findings ... plays a central role in sepsis as the endotoxin inducing a systemic inflammatory response, and LPS-induced endotoxin shock is ...
https://elifesciences.org/articles/21055
WikiGenes - Administration, TopicalWikiGenes - Administration, Topical
Mild hypothermia can enhance pial arteriolar vasodilation induced by isoflurane and sevoflurane in cats. Inoue, S., Kawaguchi, ... A model for the study of coronary spasm induced changes in cardiac metabolism. Burger, W., Chemnitius, J.M., Metz, M.Z., Bing, ... Neovasculature induced by vascular endothelial growth factor is fenestrated. Roberts, W.G., Palade, G.E. Cancer Res. (1997) [ ... Blockade of the EGF receptor induces a deranged chemokine expression in keratinocytes leading to enhanced skin inflammation. ...
https://www.wikigenes.org/e/mesh/e/100.html
The big sleep: Unlocking the secrets of suspended animation | CNNThe big sleep: Unlocking the secrets of suspended animation | CNN
He believes that by inducing hypothermia we can extend the "golden hour" in which surgeons battle to save the lives of ... At one time, famed British scientist James Lovelock researched induced hypothermia in mice. ... the UMCG team also induce forced hypothermia states like that of our rat, chilling the animals rapidly until they fall into a ... Hypothermia is dangerous. Your body wants to be warm and will fight to remain that way. Throughout your life, it will maintain ...
http://edition.cnn.com/2014/05/06/health/the-big-sleep-suspended-animation/
Frontiers | Cardiorespiratory Alterations in a Newborn Ovine Model of Systemic Inflammation Induced by Lipopolysaccharide...Frontiers | Cardiorespiratory Alterations in a Newborn Ovine Model of Systemic Inflammation Induced by Lipopolysaccharide...
Although it is well known that neonatal sepsis can induce important alterations in cardiorespiratory control, their detailed ... Although it is well known that neonatal sepsis can induce important alterations in cardiorespiratory control, their detailed ... Of note, one lamb out of eight presented marked hypothermia (max. ΔT −3°C around the 3-h time point) after the first ... The LCRs were induced with an injection of 0.5 mL HCl (pH 2) into the larynx during non-REM sleep. The PCRs were induced with ...
https://www.frontiersin.org/articles/10.3389/fphys.2020.00585/full
Erowid.org: Erowid Reference 8302 : Evidence for the role of noradrenaline in some effects of quipazine : Franc s H, Lecrubier...Erowid.org: Erowid Reference 8302 : Evidence for the role of noradrenaline in some effects of quipazine : Franc s H, Lecrubier...
In mice, quipazine has shown several behavioral effects: It antagonizes hypothermia induced by a high dose of apomorphine ... it antagonizes oxotremorine-induced hypothermia without altering tremors or peripheral signs; and it increases the toxicity of ... Quipazine, in mice pretreated with pargyline, induced head twitches which were inhibited by methysergide but not by D,L- ...
https://www.erowid.org/references/refs_view.php?ID=8302&S=depressive
المنشورات - Ronna L. Campbell, M.D., Ph.D. - Mayo Clinic (مايو كلينك)المنشورات - Ronna L. Campbell, M.D., Ph.D. - Mayo Clinic (مايو كلينك)
Severe autoimmune hemolytic anemia treated by paralysis, induced hypothermia, and splenic embolization. Chest. 2005 Feb; 127(2 ... Biphasic anaphylaxis manifested as type I Kounis syndrome induced by ingestion of raw fish gallbladder: A case report. World J ... National trends in emergency department visits and hospitalizations for food-induced anaphylaxis in US children. Pediatr ...
https://www.mayoclinic.org/ar/biographies/campbell-ronna-l-m-d-ph-d/publications/pbc-20224856
TherapeuticHyperthermiaOxotremorine-induced hypothermiaCore body temperHypotensionRisk of hypothermiaFrostbiteAccidental hypothermiaAcuteCardiac arrestNitric oxideElectrolyteMiceLipopolysaccharideReperfusionRatsCerebral2021HypothermicMetabolismIschemicPeripheralPlateletNeurolepticHyperactivityFalls below 95DescribesSepsis2019AttenuateEndothelialMetabolicExtracorporealOxidativeResuscitationDoseInductionAlcohol intoxicationEffectsCardiovascularShiveringPatientsStrokeTemperaturesDeathsEffectColdStableIntervention
Therapeutic14
  • Therapeutic hypothermia, a safe and effective treatment for neonatal encephalopathy in an intensive care setting, is not available in low-resource settings. (bmj.com)
  • Therapeutic hypothermia was achieved with both water bottles (n = 5) and the PCM mattress (n = 6). (bmj.com)
  • Simple, low-tech cooling devices can induce and maintain therapeutic hypothermia effectively in a porcine model of neonatal encephalopathy, although frequent fine tuning by adjusting the number of blankets insulating the piglet was required to maintain a stable temperature. (bmj.com)
  • The American Heart Association (2011) states that, 'Therapeutic hypothermia is the only intervention demonstrated to improve neurologic recovery after cardiac arrest' (Pp 77). (bartleby.com)
  • Clinical research should focus on improved cardiopulmonary resuscitation, re-oxygenation/ reperfusion strategies, therapeutic hypothermia, neuroprotection, neurorehabilitation, and consideration of drowning in advances made in treatment of other central nervous system disorders. (cdc.gov)
  • Laser speckle images were acquired at different temperature points, normothermia (37 Q and mild therapeutic hypothermia (34 Q. We extracted multiple hemodynamic responses simultaneously from the images, including blood flow, vessel size and deoxy-hemoglobin saturation. (elsevier.com)
  • The global decrease of blood flow, dilatation in arterioles and decrease of deoxy-hemoglobin saturation in veins at mild hypothermia suggests a beneficial role of circulatory and oxygenation changes in therapeutic hypothermia. (elsevier.com)
  • The results reported provide a circulatory explanation for the hypothermia therapeutic effects and mechanism. (elsevier.com)
  • Hypothermia was also explored as a potential therapeutic strategy to attenuate inflammation-induced functional deficits. (ucl.ac.uk)
  • Therapeutic hypothermia and temperature management. (lu.se)
  • Advances in intensive care support such as therapeutic hypothermia or new liver assist devices have been the mainstay of treatment attempting to bridge the gap from acute liver failure to liver transplantation, but the efficacy of the available devices in reducing mortality has been questioned. (biomedcentral.com)
  • Utilizing the Penn Alliance for Therapeutic Hypothermia Registry, we identified a cohort of 1311 post-arrest patients from 26 hospitals from 2010 to 2014 who remained comatose after return of spontaneous circulation. (cdc.gov)
  • This is a retrospective cohort study utilizing data from the Penn Alliance for Therapeutic Hypothermia (PATH) Registry. (cdc.gov)
  • A poster presented at the European Stroke Conference (6-9 May 2014, Nice, France) by Robbert-Jan van Hooff (Department of Neurology, Universitair Ziekenhuis Brussel, Brussels, Belgium) and colleagues reports that surface cooling of the neck with a surface cooling system could contribute to therapeutic hypothermia and neuroprotective effects in acute stroke. (neuronewsinternational.com)
Hyperthermia4
  • Here, we show that hypothermia and hyperthermia trigger bidirectional re-organization of presynaptic architecture in hippocampal neurons, resulting in synaptic strengthening, and weakening, respectively. (researchgate.net)
  • In the body temperature study, D-MA induced hyperthermia and L-MA induced hypothermia. (rti.org)
  • In combination, L-MA did not affect D-MA-induced hyperthermia. (rti.org)
  • In the comatose patient with restoration of spontaneous circulation, hypoxemia and hyperoxemia should be avoided, hyperthermia treated, and induced hypothermia (32-34 oC) considered. (cdc.gov)
Oxotremorine-induced hypothermia1
  • Diltiazem and nicardipine were without effect on oxotremorine-induced hypothermia in FRL rats. (duke.edu)
Core body temper5
  • Hypothermia is a lowering of the core body temperature to less than or equal to 95 F (less than or equal to 35 C) (1). (cdc.gov)
  • Surgical procedures are commonly performed using mice but can have major effects on their core body temperature, including development of hypothermia. (awionline.org)
  • Hypothermia occurs when your body loses heat faster than it can produce it, causing your core body temperature to fall. (hunter-ed.com)
  • How does Wim Hof manage to keep his core body temperature elevated, maintain peripheral circulation, and avoid frostbite and hypothermia? (gettingstronger.org)
  • The human physiologic response to cold exposure is to retard heat loss and preserve core body temperature, but this response may not be sufficient to prevent hypothermia if heat loss is prolonged. (health.mil)
Hypotension1
  • Vital sign changes found in patients with anorexia nervosa include hypotension, bradycardia, and hypothermia. (medscape.com)
Risk of hypothermia2
  • In an urban environment, the use of alcohol or illicit drugs, overdose, psychiatric emergency, and major trauma all are associated with an increased risk of hypothermia. (medscape.com)
  • Auciliems 2 reported that combinations of low temperatures with strong winds induced a feeling of thermal discomfort and increased the risk of hypothermia (body temperature below 35°C). Thus, the heart rate also tends to become lower, breathing slows down, and the blood vessels constrict, resulting in increased blood pressure. (bvsalud.org)
Frostbite2
  • Dr. Kenneth Kamler , an expert on hypothermia, frostbite and high-altitude medicine, who has himself climbed up Everest, has observed that Wim's trained body responds differently than yours or mine. (gettingstronger.org)
  • The term cold weather injuries is used to describe injuries that have a central effect, such as hypothermia, as well as injuries that primarily affect the peripheries of the body, such as frostbite and immersion injuries. (health.mil)
Accidental hypothermia2
  • Hypothermia occurs when the core temperature of the body falls below 95 °F.7 The most common mechanisms of accidental hypothermia are convective heat loss to cold air and conductive heat loss to water. (health.mil)
  • Wilderness Medical Society Practice Guidelines for the Out-of-Hospital Evaluation and Treatment of Accidental Hypothermia: 2014 Update. (stanford.edu)
Acute2
  • As a first approach to investigate such a role, we evaluated by immunohistochemistry EM66 expression within the pPVN following acute immune stress induced by lipopolysaccharide (LPS) or interleukin-1β (IL-1β) injection in rat. (nel.edu)
  • METHODS AND MODELS: Acute ischemic RV dysfunction was induced by progressive embolization of microsphere in the right coronary artery to mimic RV dysfunction clinically experienced during cardiopulmonary bypass separation caused by air microemboli. (bvsalud.org)
Cardiac arrest2
  • Similarly, profound hypothermia may present as coma or cardiac arrest. (medscape.com)
  • In particular, the time and the effort involved in surface-cooling a patient who experienced cardiac arrest or stroke kept hypothermia from becoming an established intervention. (dana.org)
Nitric oxide2
  • This study examined the possible upstream cellular signaling pathway associated with nitric oxide (NO)-mediated inhibition of phenylephrine-induced contraction in isolated rat aortae in response to mild hypothermia, with a particular focus on endothelial Rho-kinase. (medsci.org)
  • Finally, we examined the effects of mild hypothermia, wortmannin, Y-27632 and L-NAME, alone and combined, on endothelial nitric oxide synthase (eNOS) and endothelial Rho-kinase membrane translocation induced by phenylephrine. (medsci.org)
Electrolyte1
  • Polderman, KH & Girbes, ARJ 2002, ' Potential mechanisms of hypothermia-induced electrolyte depletion [1] (multiple letters) ', Critical Care Medicine , vol. 30, no. 8, pp. 1932-1933. (vumc.nl)
Mice8
  • We fed mice with a KD for seven days to assess the underlying mechanisms of muscle wasting induced by chronic starvation. (nature.com)
  • Feeding mice with a KD is a novel experimental animal model of muscle-wasting induced by chronic starvation. (nature.com)
  • The recent discovery that a reversible state of slowed-down metabolism closely resembling hibernation can be induced in mice, which do not naturally hibernate, has also raised the possibility that one day humans may in this way have their metabolism reduced to allow for prolonged brain or heart surgery that necessitates the cessation of blood circulation. (dana.org)
  • Here, we report that peripheral administration of the hypothalamic neuropeptide orexin improves the survival of mice with lipopolysaccharide (LPS) induced endotoxin shock, a well-studied septic shock model. (elifesciences.org)
  • At one time, famed British scientist James Lovelock researched induced hypothermia in mice. (cnn.com)
  • Quipazine, in mice pretreated with pargyline, induced head twitches which were inhibited by methysergide but not by D,L-propranolol. (erowid.org)
  • 1973). Special studies on carcinogenicity "> Special studies on pharmacological aspects "> Special studies on pharmacological aspects Intraperitoneal injection of either a 250 or 500 mg/kg dose of cinnamaldehyde to mice resulted in ataxia, analgesia, hypothermia, a decrease in spontaneous motor activity, antagonism of methamphetamine- induced hyperactivity, and prolongation of sodium hexobarbital-induced anaesthesia. (inchem.org)
  • Intraperitoneal injection of a single 250 mg/kg dose of cinnamaldehyde to mice produced an inhibition of intestinal propulsion while simultaneously protecting against the generation of stress- induced gastric erosion (Harada & Yano, 1975). (inchem.org)
Lipopolysaccharide1
  • Lipopolysaccharide (LPS), a major cell wall component of Gram negative bacteria, plays a central role in sepsis as the endotoxin inducing a systemic inflammatory response, and LPS-induced endotoxin shock is one of the several well-studied animal models of septic shock. (elifesciences.org)
Reperfusion4
  • Stroke was induced by middle cerebral artery occlusion (MCAO) for 2 h followed by 6 or 24 h of reperfusion. (researchsquare.com)
  • alpha-Difluoromethylornithine (DFMO), a specific suicide inhibitor of ODC, suppressed the calcium reperfusion-induced increase in polyamines and the concomitant increase in myocardial cellular 45Ca influx, loss of contractility, release of cytosolic enzymes, myoglobin, and protein, and structural lesions. (jci.org)
  • Putrescine, the product of ODC activity, nullified DFMO inhibition and restored the calcium reperfusion-induced increment in polyamines and the full expression of the calcium paradox. (jci.org)
  • Hypothermia blocked the changes in heart ODC and polyamines induced by calcium-free perfusion and calcium reperfusion and prevented the calcium paradox. (jci.org)
Rats2
  • We compared the effects of three chemically different calcium channel inhibitors (diltiazem, nicardipine and verapamil) on the hypothermia induced in FRL and FSL rats by oxotremorine (0.2 mg kg-1 s.c. (duke.edu)
  • Verapamil significantly (P less than 0.05) augmented oxotremorine hypothermia in FRL rats. (duke.edu)
Cerebral3
  • In this paper, we present a novel method to study the effect of induced mild hypothermia on cerebral vascular responses. (elsevier.com)
  • To measure cerebral vascular responses, a minimally invasive imaging method, temporal laser speckle imaging, was developed and adapted for induced-hypothermia rat model. (elsevier.com)
  • On the other hand, therapeutically induced hypothermia has shown promising potential in animal models of focal cerebral ischemia. (bvsalud.org)
20211
  • 2021), which is evidenced by the hypothermia-induced actin redistribution. (researchgate.net)
Hypothermic1
  • L-NAME, wortmannin, ODQ and methylene blue increased phenylephrine-induced contraction of endothelium-intact aortae pretreated at 33°C. Wortmannin did not significantly alter the L-NAME-induced enhancement of phenylephrine-induced maximal contraction of endothelium-intact aortae pretreated at 33°C. Wortmannin abolished the ability of Y-27632 to magnify the hypothermic inhibition of maximal phenylephrine-induced contraction. (medsci.org)
Metabolism2
  • In conclusion, stroke impaired glucose metabolism by enhancing hyperglycolysis and gluconeogenesis, which led to ischemic injury, all of which were reversed by PH induced by a combination of C+P and DHC. (researchsquare.com)
  • To list a few: drug overdosage, injection of an opioid (morphine) just before recovery, poor metabolism, and hypothermia. (dvm360.com)
Ischemic1
  • CARD8 and IL1B Polymorphisms Influence MRI Brain Patterns in Newborns with Hypoxic-Ischemic Encephalopathy Treated with Hypothermia. (cdc.gov)
Peripheral1
  • Ethanol abuse, which is strongly associated with hypothermia, results in vasodilation and interferes with peripheral vasoconstriction, an important physiologic mechanism of defense against the cold. (cdc.gov)
Platelet1
  • Typical indications include leukemia, myelodysplasia, aplastic anemia, solid tumors, congenital or acquired/medication-induced platelet dysfunction, central nervous system trauma, and patients undergoing extracorporeal membrane oxygenation or cardiopulmonary bypass may also need platelet transfusion. (medscape.com)
Neuroleptic1
  • Neuroleptic drugs also predispose a person to hypothermia by inducing vasodilation and suppressing the shivering response. (cdc.gov)
Hyperactivity1
  • Depriving rodents of food also induces hyperactivity. (nature.com)
Falls below 951
  • Finally, when the core temperature falls below 95 F, the various stages of hypothermia set in, ultimately leading to death if sufficiently prolonged. (gettingstronger.org)
Describes3
  • This report describes three selected cases of hypothermia-related deaths in Wisconsin and summarizes characteristics of all cases that occurred in the state during the period of active surveillance. (cdc.gov)
  • This report summarizes the investigation of three of these deaths and describes risk factors commonly associated with hypothermia. (cdc.gov)
  • He then describes his hypothermia-induced hallucination about the priesthood keys. (bycommonconsent.com)
Sepsis1
  • Although it is well known that neonatal sepsis can induce important alterations in cardiorespiratory control, their detailed early features and the mechanisms involved remain poorly understood. (frontiersin.org)
20192
  • Fra 2019 ble en ny forskrift om nasjonale retningslinjer fastsatt. (uit.no)
  • In 2019, about 1300 people in the U.S. died of hypothermia. (cdc.gov)
Attenuate1
  • L-MA did not attenuate D-MA-induced place preference. (rti.org)
Endothelial2
  • Y-27632 and L-NAME attenuated the enhancing effect of hypothermia on phenylephrine-induced endothelial Rho-kinase membrane translocation. (medsci.org)
  • The results suggest that hypothermia-induced, NO-dependent inhibition of phenylephrine-induced contraction is mediated by phosphoinositide 3-kinase and inhibited by endothelial Rho-kinase activation. (medsci.org)
Metabolic3
  • The process of refeeding must be undertaken slowly, with modest increases in metabolic demands, in order to avoid refeeding syndrome (which includes cardiovascular collapse, starvation-induced hypophosphatemia, and dangerous fluctuations in potassium, sodium, and magnesium levels). (medscape.com)
  • Elderly persons particularly are at risk for hypothermia because of medical and socioeconomic factors such as underlying diseases, social isolation, and physiologic changes (e.g., lack of appropriate vasoconstriction in response to cold environments, decreased basal metabolic rate, and impaired shivering mechanism). (cdc.gov)
  • Although few hospitals have full-fledged hypothermia programs, there is a buzz in medicine and medical industry about the possibilities of reducing the brain's metabolic needs through cooling, particularly after head trauma. (dana.org)
Extracorporeal2
  • Episodes of slight hypothermia induced by cyclic connection to the extracorporeal dummy device produced a significant survival benefit of more than 20 hours through organ protection and hemodynamic stabilisation. (biomedcentral.com)
  • Animal studies which focus on a survival benefit generated by liver assist devices should especially address the aspect of slight transient hypothermia by extracorporeal cooling. (biomedcentral.com)
Oxidative2
  • In addition to hypercorticosteronemia, hypoinsulinemia and reduced IGF-1, oxidative stress might also be involved in KD-induced muscle atrophy. (nature.com)
  • Protective effect of electrolyzed reduced water on the paraquat-induced oxidative damage of human lymphocyte DNA. (h2bev.com)
Resuscitation1
  • Hypothermia has been demonstrated to decrease post resuscitation brain injury and improve the survival in comatose patients. (sep.hr)
Dose2
  • A 500 mg/kg dose was also observed to reduce development of a tonic convulsion in a nicotine-induced convulsion. (inchem.org)
  • Administration of a 125 mg/kg dose intraperitoneally produced hypothermia, antipyretcosis, and a prolongation of hexobarbital-induced anaesthesia (Harada & Osaki, 1972). (inchem.org)
Induction1
  • Induction of hypothermia in vivo enhances inhibitory synapses in the hippocampus, but not in the cortex. (researchgate.net)
Alcohol intoxication1
  • His blood alcohol level was 230 mg/dL (intoxication is legally defined as ≥80 mg/dL in all states), and cause of death was environmental hypothermia with a contributing cause of alcohol intoxication. (cdc.gov)
Effects3
  • We examined the effects of mild hypothermia (33°C), wortmannin, N ω -nitro-L-arginine methyl ester (L-NAME), Y-27632, 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one (ODQ) and methylene blue, alone and combined, on phenylephrine-induced contraction in isolated rat aortae. (medsci.org)
  • Medical use of "induced hypothermia" has been around since the 1930s, but imprecise methods and dangerous side effects kept it from wide acceptance. (dana.org)
  • In the pilot study COOL (Effects of surface cooling on stroke outcome trial) included 20 healthy volunteers in whom surface cooling was induced using the Brain.Pad (Emcools) to noninvasively and mildly lower brain temperature. (neuronewsinternational.com)
Cardiovascular1
  • Association of arsenic-induced cardiovascular disease susceptibility with genetic polymorphisms. (cdc.gov)
Shivering1
  • If the cold exposure is prolonged more than a few minutes, goosebumps and shivering kick in to induce warming of muscles and skin. (gettingstronger.org)
Patients2
  • In addition, hypothermia is inappropriate in patients with a valid do not resuscitate order (DNR). (medscape.com)
  • Dr. Lewis innovated the model of inducing hypothermia in his patients to slow the de-oxygenation of their blood during the the time the heart is stopped during surgery. (praythroughhistory.com)
Stroke1
  • Pharmacological hypothermia (PH) is a potential neuroprotective strategy for stroke in which the temperature can be decreased safely. (researchsquare.com)
Temperatures3
  • To understand the risk factors for hypothermia-related death and improve prevention efforts, during January 1-April 30, 2014, a period of record low temperatures, the Wisconsin Division of Public Health began active surveillance for hypothermia. (cdc.gov)
  • However, hypothermia can occur at temperatures as high as 50° Fahrenheit. (hunter-ed.com)
  • 10 Freezing temperatures are not required to produce hypothermia. (health.mil)
Deaths7
  • Suspected hypothermia-related deaths were reported by coroners or medical examiners and identified in death records. (cdc.gov)
  • A summary of hypothermia-related deaths for the United States during 2003-2013 also is presented for comparison and to assess national mortality trends. (cdc.gov)
  • During January-April 2014, a total of 27 hypothermia-related deaths occurred in Wisconsin, all of which were investigated by a coroner or medical examiner. (cdc.gov)
  • Hypothermia-related deaths for the United States overall were obtained from CDC's multiple cause of death files and were defined as any death with an underlying or contributing cause of death from exposure to excessive natural cold ( International Classification of Diseases , 10th Revision [ICD-10] code X.31). (cdc.gov)
  • From 1979 through 1992, a total of 10,550 persons in the United States died from hypothermia, an average of 754 deaths per year (range: 557-1021 deaths) (2). (cdc.gov)
  • From October 1994 through February 1996, a total of 10 hypothermia-related deaths were reported by the chief medical examiner in Vermont. (cdc.gov)
  • Editorial Note: From 1979 through 1992, approximately half of all hypothermia deaths in the United States occurred among persons aged greater than or equal to 65 years ( Figure 1 ). (cdc.gov)
Effect2
  • Wortmannin and L-NAME inhibited the enhancing effect of mild hypothermia on phenylephrine-induced eNOS phosphorylation. (medsci.org)
  • In this study, the neuroprotective effect of the extract of ginger ( Zingiber officinale ) was investigated against MSG-induced neurotoxicity of male albino rat. (scialert.net)
Cold3
  • In carrying out these feats, he is able to avoid hypothermia, the normal human response to extreme cold. (gettingstronger.org)
  • Because you have less natural insulation, you can get hypothermia in cold weather. (medlineplus.gov)
  • Extremes of heat and cold can cause potentially fatal conditions, e.g. heat stress or hypothermia, as well as increasing death rates from heart and respiratory diseases. (who.int)
Stable1
  • PCM may induce more stable cooling compared with water bottles. (bmj.com)
Intervention2
  • To establish hypothermia as a viable intervention newer, faster, and better-controlled cooling techniques were needed. (dana.org)
  • Cooling devices are being developed with the expectation that induced hypothermia may become a common intervention. (dana.org)