Abnormally low BODY TEMPERATURE that is intentionally induced in warm-blooded animals by artificial means. In humans, mild or moderate hypothermia has been used to reduce tissue damages, particularly after cardiac or spinal cord injuries and during subsequent surgeries.
A form of interactive entertainment in which the player controls electronically generated images that appear on a video display screen. This includes video games played in the home on special machines or home computers, and those played in arcades.
Lower than normal body temperature, especially in warm-blooded animals.
Fabric or other material used to cover the body.
The application of electronic, computerized control systems to mechanical devices designed to perform human functions. Formerly restricted to industry, but nowadays applied to artificial organs controlled by bionic (bioelectronic) devices, like automated insulin pumps and other prostheses.
Exclusive legal rights or privileges applied to inventions, plants, etc.
Clothing designed to protect the individual against possible exposure to known hazards.
A class of opioid receptors recognized by its pharmacological profile. Kappa opioid receptors bind dynorphins with a higher affinity than endorphins which are themselves preferred to enkephalins.
A group of DITERPENES cyclized into 2-rings with a side-chain.
Cell-surface proteins that bind dopamine with high affinity and trigger intracellular changes influencing the behavior of cells.
Drugs that bind to and activate dopamine receptors.
Bacterial infections of the leptomeninges and subarachnoid space, frequently involving the cerebral cortex, cranial nerves, cerebral blood vessels, spinal cord, and nerve roots.
A profound state of unconsciousness associated with depressed cerebral activity from which the individual cannot be aroused. Coma generally occurs when there is dysfunction or injury involving both cerebral hemispheres or the brain stem RETICULAR FORMATION.
Acute and chronic (see also BRAIN INJURIES, CHRONIC) injuries to the brain, including the cerebral hemispheres, CEREBELLUM, and BRAIN STEM. Clinical manifestations depend on the nature of injury. Diffuse trauma to the brain is frequently associated with DIFFUSE AXONAL INJURY or COMA, POST-TRAUMATIC. Localized injuries may be associated with NEUROBEHAVIORAL MANIFESTATIONS; HEMIPARESIS, or other focal neurologic deficits.
Inflammation of the coverings of the brain and/or spinal cord, which consist of the PIA MATER; ARACHNOID; and DURA MATER. Infections (viral, bacterial, and fungal) are the most common causes of this condition, but subarachnoid hemorrhage (HEMORRHAGES, SUBARACHNOID), chemical irritation (chemical MENINGITIS), granulomatous conditions, neoplastic conditions (CARCINOMATOUS MENINGITIS), and other inflammatory conditions may produce this syndrome. (From Joynt, Clinical Neurology, 1994, Ch24, p6)
The measure of the level of heat of a human or animal.
An irregularly shaped cavity in the RHOMBENCEPHALON, located between the MEDULLA OBLONGATA; the PONS; and the isthmus in front, and the CEREBELLUM behind. It is continuous with the central canal of the cord below and with the CEREBRAL AQUEDUCT above, and through its lateral and median apertures it communicates with the SUBARACHNOID SPACE.
The posterior of the three primitive cerebral vesicles of an embryonic brain. It consists of myelencephalon, metencephalon, and isthmus rhombencephali from which develop the major BRAIN STEM components, such as MEDULLA OBLONGATA from the myelencephalon, CEREBELLUM and PONS from the metencephalon, with the expanded cavity forming the FOURTH VENTRICLE.
The chemical reactions involved in the production and utilization of various forms of energy in cells.
A thiourea antithyroid agent. Propythiouracil inhibits the synthesis of thyroxine and inhibits the peripheral conversion of throxine to tri-iodothyronine. It is used in the treatment of hyperthyroidism. (From Martindale, The Extra Pharmacopeoia, 30th ed, p534)
GRAY MATTER situated above the GYRUS HIPPOCAMPI. It is composed of three layers. The molecular layer is continuous with the HIPPOCAMPUS in the hippocampal fissure. The granular layer consists of closely arranged spherical or oval neurons, called GRANULE CELLS, whose AXONS pass through the polymorphic layer ending on the DENDRITES of PYRAMIDAL CELLS in the hippocampus.
A curved elevation of GRAY MATTER extending the entire length of the floor of the TEMPORAL HORN of the LATERAL VENTRICLE (see also TEMPORAL LOBE). The hippocampus proper, subiculum, and DENTATE GYRUS constitute the hippocampal formation. Sometimes authors include the ENTORHINAL CORTEX in the hippocampal formation.
A syndrome that results from abnormally low secretion of THYROID HORMONES from the THYROID GLAND, leading to a decrease in BASAL METABOLIC RATE. In its most severe form, there is accumulation of MUCOPOLYSACCHARIDES in the SKIN and EDEMA, known as MYXEDEMA.
Brain waves characterized by a frequency of 4-7 Hz, usually observed in the temporal lobes when the individual is awake, but relaxed and sleepy.
Natural hormones secreted by the THYROID GLAND, such as THYROXINE, and their synthetic analogs.
Agents that are used to treat hyperthyroidism by reducing the excessive production of thyroid hormones.
A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.
A plasma membrane exchange glycoprotein transporter that functions in intracellular pH regulation, cell volume regulation, and cellular response to many different hormones and mitogens.
Proteins involved in the transport of specific substances across the membranes of the MITOCHONDRIA.
The restoration to life or consciousness of one apparently dead. (Dorland, 27th ed)
The artificial substitution of heart and lung action as indicated for HEART ARREST resulting from electric shock, DROWNING, respiratory arrest, or other causes. The two major components of cardiopulmonary resuscitation are artificial ventilation (RESPIRATION, ARTIFICIAL) and closed-chest CARDIAC MASSAGE.
Compounds that bind to and inhibit that enzymatic activity of LIPOXYGENASES. Included under this category are inhibitors that are specific for lipoxygenase subtypes and act to reduce the production of LEUKOTRIENES.
The major metabolite in neutrophil polymorphonuclear leukocytes. It stimulates polymorphonuclear cell function (degranulation, formation of oxygen-centered free radicals, arachidonic acid release, and metabolism). (From Dictionary of Prostaglandins and Related Compounds, 1990)
Compounds or agents that combine with cyclooxygenase (PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES) and thereby prevent its substrate-enzyme combination with arachidonic acid and the formation of eicosanoids, prostaglandins, and thromboxanes.
An enzyme that catalyzes the oxidation of arachidonic acid to yield 5-hydroperoxyarachidonate (5-HPETE) which is rapidly converted by a peroxidase to 5-hydroxy-6,8,11,14-eicosatetraenoate (5-HETE). The 5-hydroperoxides are preferentially formed in leukocytes.
Occurrence of heart arrest in an individual when there is no immediate access to medical personnel or equipment.
Cessation of heart beat or MYOCARDIAL CONTRACTION. If it is treated within a few minutes, heart arrest can be reversed in most cases to normal cardiac rhythm and effective circulation.
Dilation of an occluded coronary artery (or arteries) by means of a balloon catheter to restore myocardial blood supply.
A family of percutaneous techniques that are used to manage CORONARY OCCLUSION, including standard balloon angioplasty (PERCUTANEOUS TRANSLUMINAL CORONARY ANGIOPLASTY), the placement of intracoronary STENTS, and atheroablative technologies (e.g., ATHERECTOMY; ENDARTERECTOMY; THROMBECTOMY; PERCUTANEOUS TRANSLUMINAL LASER ANGIOPLASTY). PTCA was the dominant form of PCI, before the widespread use of stenting.
Services specifically designed, staffed, and equipped for the emergency care of patients.

L-[1-11C]-tyrosine PET to evaluate response to hyperthermic isolated limb perfusion for locally advanced soft-tissue sarcoma and skin cancer. (1/1261)

PET with L-[1-11C]-tyrosine (TYR) was investigated in patients undergoing hyperthermic isolated limb perfusion (HILP) with recombinant tumor necrosis factor alpha (rTNF-alpha) and melphalan for locally advanced soft-tissue sarcoma and skin cancer of the lower limb. METHODS: Seventeen patients (5 women, 12 men; age range 24-75 y; mean age 52 y) were studied. TYR PET studies were performed before HILP and 2 and 8 wk afterwards. The protein synthesis rates (PSRs) in nanomoles per milliliter per minute were calculated. After final PET studies, tumors were resected and pathologically examined. Patients with pathologically complete responses (pCR) showed no viable tumors after treatment. Those with pathologically partial responses (pPR) showed various amounts of viable tumors in the resected tumor specimens. RESULTS: Six patients (35%) showed a pCR and 11 patients (65%) showed a pPR. All tumors were depicted as hot spots on PET studies before HILP. The PSR in the pCR group at 2 and 8 wk after perfusion had decreased significantly (P < 0.05) in comparison to the PSR before HILP. A significant difference was found in PSR between the pCR and pPR groups at 2 and at 8 wk (P < 0.05). Median PSR in nonviable tumor tissue was 0.62 and ranged from 0.22 to 0.91. With a threshold PSR of 0.91, sensitivity and specificity of TYR PET were 82% and 100%, respectively. The predictive value of a PSR > 0.91 for having viable tumor after HILP was 100%, whereas the predictive value of a PSR < or = 0.91 for having nonviable tumor tissue after HILP was 75%. The 2 patients in the pPR groups with a PSR < 0.91 showed microscopic islets of tumor cells surrounded by extensive necrosis on pathological examination. CONCLUSION: Based on the calculated PSR after HILP, TYR PET gave a good indication of the pathological outcome. Inflammatory tissue after treatment did not interfere with viable tumor on the images, suggesting that it may be worthwhile to pursue TYR PET in other therapy evaluation settings.  (+info)

Hypothermic neuroprotection of peripheral nerve of rats from ischaemia-reperfusion injury. (2/1261)

Although there is much information on experimental ischaemic neuropathy, there are only scant data on neuroprotection. We evaluated the effectiveness of hypothermia in protecting peripheral nerve from ischaemia-reperfusion injury using the model of experimental nerve ischaemia. Forty-eight male Sprague-Dawley rats were divided into six groups. We used a ligation-reperfusion model of nerve ischaemia where each of the supplying arteries to the sciatic-tibial nerves of the right hind limb was ligated and the ligatures were released after a predetermined period of ischaemia. The right hind limbs of one group (24 rats) were made ischaemic for 5 h and those of the other group (24 rats) for 3 h. Each group was further divided into three and the limbs were maintained at 37 degrees C (36 degrees C for 5 h of ischaemia) in one, 32 degrees C in the second and 28 degrees C in the third of these groups for the final 2 h of the ischaemic period and an additional 2 h of the reperfusion period. A behavioural score was recorded and nerve electrophysiology of motor and sensory nerves was undertaken 1 week after surgical procedures. At that time, entire sciatic-tibial nerves were harvested and fixed in situ. Four portions of each nerve were examined: proximal sciatic nerve, distal sciatic nerve, mid-tibial nerve and distal tibial nerve. To determine the degree of fibre degeneration, each section was studied by light microscopy, and we estimated an oedema index and a fibre degeneration index. The groups treated at 36-37 degrees C underwent marked fibre degeneration, associated with a reduction in action potential and impairment in behavioural score. The groups treated at 28 degrees C (for both 3 and 5 h) showed significantly less (P < 0.01; ANOVA, Bonferoni post hoc test) reperfusion injury for all indices (behavioural score, electrophysiology and neuropathology), and the groups treated at 32 degrees C had scores intermediate between the groups treated at 36-37 degrees C and 28 degrees C. Our results showed that cooling the limbs dramatically protects the peripheral nerve from ischaemia-reperfusion injury.  (+info)

Myocardial temperature reduction attenuates necrosis after prolonged ischemia in rabbits. (3/1261)

OBJECTIVE: Previously we observed that a large reduction in infarct size was attained by cooling the risk region of the heart, either before or early after the onset of a 30-min coronary artery occlusion. While this is a standard duration of ischemia used in the rabbit model of infarction, it may not reflect the situation of patients who are reperfused late. The effects of regional hypothermia with a longer duration of ischemia, and when the intervention is applied later, are unknown. This study tests the hypothesis that a local reduction in cardiac temperature protects myocardium during prolonged ischemia (2 h) even if begun well after coronary artery occlusion. METHODS: Anesthetized rabbits received 2 h of coronary artery occlusion and 3 h of reperfusion. Rabbits were randomly assigned to a treated group: topical myocardial cooling starting 30 min after coronary occlusion (n = 14), or control group, no intervention (n = 12). Myocardial temperature in the risk zone, hemodynamics and regional myocardial blood flow were measured. RESULTS: Ischemic zone temperature was similar in both groups at 30 min post occlusion, but the cooling maneuver produced a reduction in temperature in the risk region of the treated group such that myocardial temperature was reduced an average of 10 degrees C between 30 and 60 min of coronary artery occlusion. Myocardial temperature in the control group remained within 0.3 degree C of baseline during coronary artery occlusion and into reperfusion. Core temperatures were similar in both groups. Hemodynamic parameters and collateral blood flow during occlusion were also equivalent in both groups. After 120 min of coronary occlusion, necrosis in the control group comprised 72 +/- 3% of the ischemic risk region. However, in cooled hearts, infarct size, expressed as a fraction of the risk region was significantly lower. Infarct size in this group averaged 59 +/- 3% of the risk region (p < 0.004 vs. controls), and thus cooling resulted in a salvage of approximately 18% of the risk region. CONCLUSION: These results show that reducing myocardial temperature protects ischemic myocardium during a long duration of ischemia even if initiated after coronary artery occlusion.  (+info)

RVLM and raphe differentially regulate sympathetic outflows to splanchnic and brown adipose tissue. (4/1261)

To determine whether neurons in the rostral raphe pallidus (RPa) specifically control the sympathetic nerve activity to brown adipose tissue (BAT SNA), thereby regulating adipocyte metabolism and BAT thermogenesis, the responses in BAT SNA to disinhibition of RPa neurons and to disinhibition of neurons in the vasomotor region of the rostral ventrolateral medulla (RVLM) were compared with those in splanchnic (Spl) SNA, which primarily regulates visceral vasoconstriction. In urethan-chloralose-anesthetized ventilated rats, both acute hypothermia and microinjection of bicuculline into RPa produced significantly larger increases in BAT SNA (542 and 1,949% of control) than in Spl SNA (19 and 24% of control). The enhanced burst discharge in BAT SNA was not coherent with that in Spl SNA or with the arterial pressure (AP) at any frequency except the central respiratory frequency. Microinjections of bicuculline into RVLM evoked increases in Spl SNA (86% of control) and AP (32 mmHg), but reduced BAT SNA to low, normothermic levels. Microinjections of muscimol into RVLM reduced Spl SNA (-82% of control) and AP (-59 mmHg), but did not prevent the increase in BAT SNA after disinhibition of RPa neurons. These results indicate that the neural networks generating BAT SNA in response to disinhibition of RPa neurons are independent of those generating basal Spl SNA and support a model in which sympathetic outflow to tissues involved in thermoregulation and metabolism is regulated by central pathways, including neurons in RPa, that are distinct from those involved in the sympathetic control of the cardiovascular system.  (+info)

A comparative study between hypothermic and normothermic cardiopulmonary bypass in open heart surgery in dogs--effects on systemic hemodynamics. (5/1261)

Open heart surgery was performed on two groups of dogs under extracorporeal circulation with or without hypothermia to investigate hemodynamic changes during extracorporeal circulation. During hypothermic cardiopulmonary bypass (CPB), arterial O2 tension and postoperative blood pressure were favorably maintained, indicating that hypothermic extracorporeal circulation can be performed for a long period of time. On the other hand, during normothermic CPB, the average surgical duration was significantly shorter, and marked shifts in the concentrations of various enzymes were suppressed. However, due to reductions in arterial O2 tension, the length of cardiac arrest time was restricted, demonstrating that this method is suitable for performing extracorporeal circulation for CPB of relatively short duration. If circulation circuitry can be improved, such as through the development of a surpassing oxygenator, normothermic CPB would incur less stress on the body, thus making it preferential to hypothermic CPB in most cases.  (+info)

Peroxisome proliferator-activated receptor alpha mediates the adaptive response to fasting. (6/1261)

Prolonged deprivation of food induces dramatic changes in mammalian metabolism, including the release of large amounts of fatty acids from the adipose tissue, followed by their oxidation in the liver. The nuclear receptor known as peroxisome proliferator-activated receptor alpha (PPARalpha) was found to play a role in regulating mitochondrial and peroxisomal fatty acid oxidation, suggesting that PPARalpha may be involved in the transcriptional response to fasting. To investigate this possibility, PPARalpha-null mice were subjected to a high fat diet or to fasting, and their responses were compared with those of wild-type mice. PPARalpha-null mice chronically fed a high fat diet showed a massive accumulation of lipid in their livers. A similar phenotype was noted in PPARalpha-null mice fasted for 24 hours, who also displayed severe hypoglycemia, hypoketonemia, hypothermia, and elevated plasma free fatty acid levels, indicating a dramatic inhibition of fatty acid uptake and oxidation. It is shown that to accommodate the increased requirement for hepatic fatty acid oxidation, PPARalpha mRNA is induced during fasting in wild-type mice. The data indicate that PPARalpha plays a pivotal role in the management of energy stores during fasting. By modulating gene expression, PPARalpha stimulates hepatic fatty acid oxidation to supply substrates that can be metabolized by other tissues.  (+info)

Ischemic preconditioning and myocardial hypothermia in rabbits with prolonged coronary artery occlusion. (7/1261)

This study tests whether combining regional hypothermia and ischemic preconditioning (IP) provides greater myocardial protection during prolonged coronary artery occlusion (CAO) than either intervention alone, and whether increasing the duration of IP from 5 to 7 min extends the window of protection to include a 2-h CAO. Anesthetized rabbits were randomized to four groups (n = 8 rabbits/group): control (C), hypothermia alone (H), IP alone for two 7-min episodes (IP7), and IP plus hypothermia (H + IP7). To compare differences in IP for 5 versus 7 min, additional rabbits (n = 6) received one 5-min episode of ischemia (IP5). All rabbits got 2 h of CAO and 3 h of reperfusion. In comparison with the infarct size in the control group (72 +/- 4% of the risk zone), infarct size was significantly reduced in H (50 +/- 7%), IP7 (49 +/- 5%), and H + IP7 (42 +/- 6%) (all P < 0.05 vs. control group). IP5 failed to confer protection (67 +/- 5% of the risk zone). Therefore, IP can protect against a 2-h CAO if the IP regimen is increased from 5 to 7 min. The combination therapy significantly improved regional myocardial blood flow in the previously ischemic region to a greater extent than either treatment alone.  (+info)

Effect of mild hypothermia on the changes of cerebral blood flow, brain blood barrier and neuronal injuries following reperfusion of focal cerebral ischemia in rats. (8/1261)

OBJECTIVE: To compare the effects of mild hypothermia induced in different time courses on rats subjected to 3 hours (h) of ischemia followed by 3 h or 72 h of reperfusion. METHODS: Eighty male Sprague-Dawley rats were divided into three mild hypothermic (MHT, 32 +/- 0.2 degrees C) groups, including intra-ischemia (MHTi), intra-reperfusion (MHTr), and intra-ischemia/reperfusion (MHTi + r) group, and one normothermic group (NT, 37 +/- 0.2 degrees C) as the control. Reversible focal ischemia was carried out in rats with suture model. The cortical blood flow was measured during 3 h of ischemia followed by 3 h of reperfusion. The permeability of brain blood barrier (BBB) was estimated after 3 h of reperfusion. The infarct volume was measured at 72 h after reperfusion to determine the effects of MHT. RESULTS: The acute post-ischemic hyperperfusion and delayed hypoperfusion in ischemic perifocal region and sustained hypoperfusion in ischemic core were inhibited in MHTi + r and MHTi rats (P < 0.05). MHTi + r protection on post-ischemic progressive hypoperfusion in the perifocal region was more effective than that of MHTi (P < 0.05). The BBB disruption and the infarct volume were significantly reduced in both MHTi and MHTi + r groups (P < 0.05), especially in the MHTi + r rats. CONCLUSIONS: This study demonstrates that MHTi + r has more substantial protective effects on reducing ischemia/reperfusion injury than MHTi. It may inhibit post-ischemic hyperperfusion and delayed or sustained hypoperfusion in ischemic perifocal regions, and reduce brain blood barrier disruption in the cortex region.  (+info)

Objective(s): The aim of this study wasto investigate the effects of mild hypothermia therapy on oxidative stress injury of rabbit brain tissue after cardiopulmonary resuscitation (CPR). Materials and Methods: Rabbit models of cardiac arrest were established. After the restoration of spontaneous circulation, 50 rabbits were randomly divided into normothermia and hypothermia groups. The following five time points were selected: before CPR, immediately after CPR, 2 hr after CPR (hypothermia group reached the target temperature), 14 hr after CPR (hypothermia group before rewarming), and 24 hr after CPR (hypothermia group recovered to normal temperature). Glutathione (GSH) concentrations in both the blood and cerebrospinal fluid of the normothermia and hypothermia groups were measured. Results:At 2, 14, and 24 hr after CPR, the GSH concentrations in both the blood and cerebrospinal fluid were significantly higher in the hypothermia group than in the nomorthermia group. Conclusion:Mild hypothermia therapy
Treatment of Hypothermia is abnormally low body temperature. It is a dangerous condition caused when your body loses more heat than it can produce. It requires immediate medical attention, Hyperthermia, Hypothermia Symptoms, Hypothermia Causes, Hypothermia Definition, Hypothermia Treatment, Hypothermia Diagnosis, Hypothermia Risk Factors, Hypothermia Syndrome, Hypothermia Prevention, Hypothermia Signs, Hypothermia Therapy, Acute Hypothermia, Chronic Hypothermia, Effects Of Hypothermia, Hypothermia Emedicine, Hypothermia Surgery
The aim of the present study was to investigate the impact of the time interval from collapse to return of spontaneous circulation (CPA-ROSC) in cardiac arrest patients and the types of patients who will benefit from therapeutic hypothermia. Four hundred witnessed adult comatose survivors of out-of-hospital cardiac arrest of cardiac etiology were enrolled in the study. The favorable neurological outcome was defined as category 1 or 2 on the five-point Pittsburgh cerebral performance scale at the time of hospital discharge. A matching process based on the propensity score was performed to equalize potential prognostic factors in the hypothermia and normothermia groups, and to formulate a balanced 1:1 matched cohort study. The rate of favorable neurological outcome was higher (P | 0.05) in the hypothermia group (n = 110) than in the normothermia group in patients with CPA-ROSC of 15 to 20 minutes (64% vs. 17%), 20 to 25 minutes (70% vs. 8%), 25 to 30 minutes (50% vs. 7%), 35 to 40 minutes (27% vs. 0%) and
BACKGROUND: Mild hypothermia treatment (32-34°C) in survivors after cardiac arrest (CA) is clearly recommended by the current guidelines. The effects of cooling procedure towards QT interval have not been evaluated so far outside of case series. In
This is a pilot study which will test the safety and feasibility of hypothermia treatment as adjunct therapy to conventional treatment of hyperammonemic encephalopathy (HAE) in neonates versus conventional treatment (dialysis, nutritional therapy, and ammonia scavenging drugs) only. The endpoint of the pilot study will be reached when either 24 patients have been enrolled and no serious adverse events were observed, when no patient has been enrolled in 5 years, or when serious adverse events occur which are clearly linked to the use of hypothermia. These would be serious complications not seen in patients on conventional therapy (dialysis , nutritional therapy, ammonia scavenging drugs) for HAE ...
Health, ...Therapeutic hypothermia cooling the body and brain down to 33C is th... Our results show that it is just as effective both for survival and ...,Study,questions,hypothermia,treatment,for,cardiac,arrest,medicine,medical news today,latest medical news,medical newsletters,current medical news,latest medicine news
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Fig. 9. Histograms showing the proinflammatory cytokine expression in the ipsilateral cuneate nucleus (CN) on day 7 after chronic constriction injury (CCI) in rats treated with regional or whole-body hypothermia. A significant decrease in levels of tumor necrosis factor (TNF)-α (A ) and interleukin (IL)-1β (B ) was observed after applying regional hypothermia (P , 0.05, by two-way ANOVA). In rats pretreated with mild or deep regional hypothermia, there was a significant decrease in TNF-α (A ) and IL-1β (B ) levels compared with those pretreated with regional normothermia (*P , 0.05, by Tukey test). Similarly, in the 5 h postinjury group, TNF-α (A ) and IL-1β (B ) levels in the CN were significantly decreased in CCI rats that received mild or deep regional hypothermia compared with those that received regional normothermia (*P , 0.05, by Tukey test). In addition, deep regional hypothermia administered preinjury and 5 h postinjury more effectively suppressed TNF-α (A ) and IL-1β (B ) ...
Patients often regain consciousness 3 days or more after arrest. Physicians may be making premature predictions about which patients are not likely to survive following cardiac arrest - and even withdrawing care -- before the window in which comatose patients who have received therapeutic hypothermia are most likely to wake up, according to two new studies from the Perelman School of Medicine at the University of Pennsylvania. The research helps to better define the proper timeframe and manner in which doctors may be able to predict which patients will regain consciousness after the use of therapeutic hypothermia, which preserves brain and other organ function following cardiac arrest.. Patients treated with hypothermia often dont regain consciousness until three or more days after their cardiac arrest, according Penn research that will present today at the American Heart Associations annual Scientific Sessions (Abstract #10778. But in a separate Penn study published online this week in ...
Enteral Feeding during therapeutic hypothermia, 978-3-659-61988-5, The basic provision of nutrition in the critical care population has been associated with reduced length of stay and improved outcome. Often catabolic, these patients are at risk of malnutrition. Government bodies advise and expect those requiring mechanical ventilation during critical illness to be enterally fed wherever possible. Cardiac arrest victims treated with neuroprotective therapeutic hypothermia often encounter the postponement of enteral feed until normothermia is restored. This is due to a lack of research evidence surrounding the ability for a hypothermic patient to absorb feed formulas. This is the first known study that sought to identify what percentage of feed could be tolerated by cooled victims of cardiac arrest during three distinct phases of therapeutic hypothermia. This included 24 hours at target temperature (32-34°C), 24 hours rewarming to 36.5°C and 24 hours maintained at a core temperature below 37.5°C. A
TY - JOUR. T1 - Asphyxiated neonates who received active therapeutic hypothermia during transport had higher rates of hypocapnia than controls. AU - Szakmar, Eniko. AU - Kovacs, Kata. AU - Meder, Unoke. AU - Bokodi, Geza. AU - Szell, Andras. AU - Somogyvari, Zsolt. AU - Szabo, Attila J.. AU - Szabó, M.. AU - Jermendy, Agnes. PY - 2018/1/1. Y1 - 2018/1/1. N2 - Aim: We investigated the association between active hypothermia and hypocapnia in neonates with moderate-to-severe hypoxic-ischaemic encephalopathy (HIE) transported after birth. Methods: This was a retrospective cohort study of neonates with HIE born between 2007 and 2011 and transported to Semmelweis University, Hungary, for hypothermia treatment before and after we introduced active cooling during transport in 2009. Of these, 71 received intensive care plus controlled active hypothermia during transport, while the 46 controls just received standard intensive care. Incident hypocapnia was defined as a partial pressure of carbon-dioxide ...
BACKGROUND: Induction of mild therapeutic hypothermia (TH; temperature 32-34°C) has become standard of care in many hospitals for comatose survivors of cardiac arrest. Pyrexia, or fever, is known to be detrimental in patients with neurologic injuries such as stroke or trauma. The incidence of pyrexia in the postrewarming phase of TH is unknown. We attempted to determine the incidence of fever after TH and hypothesized that those patients who were febrile after rewarming would have worse clinical outcomes than those who maintained normothermia in the postrewarming period.. METHODS: Retrospective data analysis of survivors of out-of-hospital cardiac arrest (OHCA) over a period of 29 months (December 2007 to April 2010).. INCLUSION CRITERIA: OHCA, age ,18, return of spontaneous circulation, and treatment with TH.. EXCLUSION CRITERIA: traumatic arrest and pregnancy. Data collected included age, sex, neurologic outcome, mortality, and whether the patient developed fever (temperature , 100.4°F, ...
We showed in a previous experimental study that moderate hypothermia during CPB increases IL10 blood concentrations and blunts TNFα production (2). We demonstrate here that systemic moderate hypothermia leads to increased gene expression and synthesis of IL10 in the myocardium after CPB and that this is related to myocardial protection. Despite the short observational period of 6 h, which did not allow us to extrapolate the outcome of the animals investigated, a substantial clinical benefit could be noticed, wherein the need for inotropic support to maintain stable hemodynamics was less in animals that were in moderate hypothermia during surgery. This cardioprotective effect of moderate hypothermia related to anti-inflammatory cytokine balance shown here could justify its use in clinical practice, especially in patients with severe preoperative heart failure in whom pro-inflammatory cytokine synthesis in the myocardium is thought to contribute to myocardial dysfunction (4).. The mechanisms by ...
Cardiac arrest occurs when the heart suddenly stops beating and blood flow to the body is halted. It can occur while people are in the hospital because of a medical condition or while people are out of the hospital as a result of an accident or other cause. Cardiac arrest is a serious event that is associated with high rates of death and long-term disability. When a person experiences cardiac arrest,insufficient amount of blood flow and oxygen can result in brain injury.. Therapeutic hypothermia is a therapy that involves a controlled lowering of the body temperature and then maintenance of this lower temperature for a period of time. Therapeutic hypothermia has been successfully used in adults who experience cardiac arrest to improve survival rates and health outcomes, and it has also been studied in newborn infants who have suffered from perinatal asphyxia. The purpose of this study is to evaluate the efficacy of therapeutic hypothermia at improving survival rates and reducing brain injury in ...
TY - JOUR. T1 - Absent SEP during therapeutic hypothermia did not reappear after re-warming in comatose patients following cardiac arrest. AU - Grippo, A.. AU - Carrai, R.. AU - Fossi, S.. AU - Cossu, C.. AU - Mazzeschi, E.. AU - Peris, A.. AU - Bonizzoli, M.. AU - Ciapetti, M.. AU - Gensini, G. F.. AU - Pinto, F.. AU - Amantini, A.. PY - 2013/4. Y1 - 2013/4. N2 - Background. Early prediction of neurological outcome for patients resuscitated from cardiac arrest (CA) is a challenging task. Therapeutic hypothermia (TH) has been shown to improve neurological outcome after CA. Two recent studies indicated that somatosensory evoked potentials (SEP) recorded during TH retains high prediction value for poor neurological outcome. It remains unclear whether TH can influence the recovery of bilaterally absent (BA) N20 after re-warming. The primary endpoint of the present study was to evaluate if patients with BA SEPs during TH can recover cortical responses after re-warming. The secondary endpoint was to ...
1Hospital for Sick Children, Toronto, ON, Canada, 2Toronto General Hospital, Toronto, ON, Canada. Introduction: In reconstructive surgery, skeletal muscle may endure protracted ischemia before reperfusion which may lead to significant ischemia/reperfusion injury. Other investigators reported that low local hypothermia (local cooling at 4-10°C) significantly reduced ischemia/reperfusion injury in skeletal muscle of different species of laboratory animals. However, this range of severe low local hypothermia is known to induce capillary damage. More recently, other investigators reported that low local mild hypothermia at 32-34°C significantly reduced ischemia/reperfusion injury in rabbit rectus femoris muscle in vivo. However, this infarct protective effect of low local hypothermia has not been tested in human skeletal muscle. The objective of this study was to use our established ex vivo human skeletal muscle culture model to study the efficacy of low local mild hypothermia (30-32°C) in ...
Purpose: The aim of our study was to assess the effect of hypothermia on histological damage in 19 brain regions after prolonged cardiac arrest in pigs.. Methods: Pigs were anaesthetized and mechanically ventilated. After stabilisation of pulmonary artery temperature (Tpa) at 38.5±0.2 °C, ventricular fibrillation (VF) was induced and 10 min of untreated VF were followed by 8 min of cardiopulmonary resuscitation (mechanical chest compressions, two doses of vasopressin 0.4 IE/kg). At 8 min of CPR, up to 3 countershocks were delivered. Pigs that had return of spontaneous circulation (ROSC) were randomized to one of 2 groups (control, hypothermia). Pigs in the hypothermia group were cooled to Tpa 33.0±1.0 °C with a surface cooling device (LRS Thermosuit™) circulating ice water over most of the skin surface. Pigs in the control group were kept at 38.5±1.0 °C throughout the experiment. After 14 hours of hypothermia, pigs were rewarmed, weaned and brought to the stable. At day 9 of the ...
Background: Therapeutic hypothermia has been known to reduce post-resuscitation neurological deficit and protect the cardiomyocyte from ischemia/reperfusion injury.. Hypothesis: Rapid brain cooling during CPR followed by systemic cooling reduces the severity of post-resuscitation myocardial dysfunction after prolonged ventricular fibrillation (VF). Methods: VF was induced in 16 domestic pigs and untreated for 10 minutes. CPR was then initiated for 5 minutes before defibrillation attempts. Coincident with starting CPR, the hypothermia group (n=8) was cooled by a Rhinochill device, which cooled the brain, followed by systemic hypothermia. The cooling was continued to achieve a target core temperature of 34°C.The body temperature of the control group was not intervened after VF was induced. Transthoracic echocardiography was performed before VF, hourly after return of spontaneous circulation (ROSC) for 4 hours, and at 96 hours.. Results: Both myocardial systolic (LVEF) and diastolic (isovolumic ...
Dive into the research topics of EFFECT OF POST-ISCHEMIC MILD HYPOTHERMIA ON THE LEVELS OF IMPORTANT CYTOKINES IN THE ENDOTHELIN-1 RAT MODEL FOR FOCAL CEREBRAL ISCHEMIA. Together they form a unique fingerprint. ...
Stone heart resulting from ischemic contracture of the myocardium, precludes successful resuscitation from ventricular fibrillation (VF). We hypothesized that mild hypothermia might slow the progression to stone heart. Fourteen swine (27 ± 1 kg) were randomized to normothermia (group I; n = 6) or hypothermia groups (group II; n = 8). Mild hypothermia (34 ± 2°C) was induced with ice packs prior to VF induction. The LV and right ventricular (RV) cross-sectional areas were followed by cardiovascular magnetic resonance until the development of stone heart. A commercial 1.5T GE Signa NV-CV/i scanner was used. Complete anatomic coverage of the heart was acquired using a steady-state free precession (SSFP) pulse sequence gated at baseline prior to VF onset. Un-gated SSFP images were obtained serially after VF induction. The ventricular endocardium was manually traced and LV and RV volumes were calculated at each time point. In group I, the LV was dilated compared to baseline at 5 minutes after VF and this
Encephalopathy in the late preterm and term infant is an important clinical condition because it can be associated with death or poor neurodevelopment in early childhood. Stages of encephalopathy (mild, moderate, and severe) soon after birth have value in predicting outcome during early infancy and even at early school-age. Prompt recognition after birth of the subset of infants in whom encephalopathy is associated with hypoxia-ischemia (hypoxic-ischemic encephalopathy [HIE]) is critical because the outcome is potentially modifiable with therapeutic hypothermia. A series of large randomized clinical trials have provided better estimates of the outcomes of moderate and severe HIE compared with the era before the hypothermia trials. Therapeutic hypothermia reduces the composite outcome of death or a major disability at 18 months to 2 years of age among term infants who have moderate or severe encephalopathy. School-age follow-up of a limited number of infants from these trials indicates that death ...
The prevention of ischemic injury to preserve both end-organ function and improve neurological recovery by the implementation of therapeutic hypothermia has been well established in the literature. However, not only the means by which body temperature is cooled but also the rate by which target temperature is attained remains an area of continued interest and research. The induction of therapeutic hypothermia to begin the process of body temperature lowering through the infusion of a cold solution intravenously into the body may be one variable that influences not only rapidity of cooling but also subsequent clinical outcome. In a recent issue of Critical Care, Skulec and colleagues compared the induction of therapeutic hypothermia by cold normal saline versus cold colloid solution containing hydroxyethyl starch in a porcine animal model of cardiac arrest, assessing both the rate of temperature change and target temperature achieved, in addition to changes in intracranial pressure.
TY - JOUR. T1 - Therapeutic hypothermia for anoxic brain injury following cardiac arrest. T2 - A cool transition toward cardiopulmonary cerebral resuscitation. AU - Broccard, Alain. PY - 2006/7/1. Y1 - 2006/7/1. KW - Anoxic brain injury. KW - Cardiac arrest. KW - Cardiopulmonary resuscitation. KW - Coma. KW - Human. KW - Retrospective study. KW - Therapeutic hypothermia. UR - http://www.scopus.com/inward/record.url?scp=33745586041&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=33745586041&partnerID=8YFLogxK. U2 - 10.1097/01.CCM.0000226836.72913.C4. DO - 10.1097/01.CCM.0000226836.72913.C4. M3 - Editorial. C2 - 16801865. AN - SCOPUS:33745586041. VL - 34. SP - 2008. EP - 2009. JO - Critical Care Medicine. JF - Critical Care Medicine. SN - 0090-3493. IS - 7. ER - ...
Neuronal injury is one of the key factors in determining outcome after cardiac arrest. Cerebral resuscitation starts with rapid restoration of spontaneous circulation by immediate CPR and defibrillation and continues in the postresuscitation period. Basic measures consist of good critical care practice, such as maintaining normotension, normoglycemia, and normocapnia. In addition, several more specific postresuscitation treatment options have been explored in recent years. All therapies for cerebral resuscitation must face the challenge presented by the complex pathophysiological network, which is activated by global ischemia. An effective therapy should act on multiple pathways simultaneously. This is what therapeutic hypothermia does. Two large randomized clinical trials have proven that mild therapeutic hypothermia is effective in improving both survival and neurological outcome of patients after out-of-hospital cardiac arrest. Mild therapeutic hypothermia of 32°C-34°C for 12-24 h is, ...
During therapeutic hypothermia, doctors reduce a patients body temperature to prevent cellular damage. See how therapeutic hypothermia saves lives.
Background and Purpose. Studies have shown that inter-ischemia hypothermia is able to reduce the size of myocardial infarctions and improve their clinical outcomes. The present study determined whether inter-ischemia hypothermia induced by pharmacological approach induced stronger neuroprotection in ischemic brains. Methods. Adult male Sprague-Dawley rats were studied in 4 groups: (1) sham; (2) stroke; (3) stroke treated with pharmacological hypothermia before reperfusion (inter-ischemia hypothermia); and (4) stroke treated with pharmacological hypothermia after reperfusion is initiated (inter-reperfusion hypothermia). The combination of chlorpromazine and promethazine with dihydrocapsaicin was used to induce hypothermia. To compare the neuroprotective effects of drug-induced hypothermia between the groups, brain damage was evaluated using infarct volume and neurological deficits. In addition, mRNA expressions of NADPH oxidase subunits and glucose transporter subtypes were determined by real-time PCR.
TY - JOUR. T1 - Postischemic hypothermia and IL-10 treatment provide long-lasting neuroprotection of CA1 hippocampus following transient global ischemia in rats. AU - Dietrich, W. Dalton. AU - Busto, Raul. AU - Bethea, John R.. N1 - Funding Information: This study was supported by U.S. PHS Grants NS05820 and NS27127, grants from the Paralyzed Veterans of America (1890-01), the American Paralysis Association (BA1-9802-2), and The Miami Project to Cure Paralysis. We gratefully appreciate Dr. Narula and Schering-Plough Pharmaceuticals for supplying the IL-10 for these studies. The authors thank Isabel Saul and Susan Kraydieh for technical support and Charlaine Rowlette for word processing and editorial assistance.. PY - 1999/8. Y1 - 1999/8. N2 - Experimental studies have demonstrated that postischemic therapeutic interventions may delay rather than provide long-lasting neuroprotection. The purpose of this study was to determine whether mild hypothermia (33-34°C) combined with the anti-inflammatory ...
INTRODUCTION: Innovation is a hallmark of surgical practice. It is generally accepted that a new procedure will undergo technical changes during its evolution; however, quantitative accounts of the process are limited. METHODS: Multiple groups, including our own, have recently described a minimally-invasive approach to conventional kidney transplantation (KT) operation. Unique to our experience is a structured development of the technique within the confines of a safe surgical innovation framework - the IDEAL framework (idea, development, exploration, assessment, long-term monitoring; stages 0-4). We here provide a first-hand narrative of the progress of robotic KT operation from preclinical trial to clinical application. RESULTS: Overall, 54 patients underwent robotic KT with regional hypothermia successfully. Major technical changes including selection of optimal patient position (flank vs. lithotomy), robotic instrumentation, vascular occlusion method (bulldog vs. tourniquet) and suture material
Abstract: : Purpose: The present study was designed to examine the changes in the electroretinogram (ERGs) during postischemic reperfusion in young (4 months old) and aged (over 18 months old) Wistar rats under normothermic and hypothermic conditions. Methods: The ERG responses to single white light flashes were recorded by Ag/AgCl electrodes placed on the cornea. Ocular ischemia was induced by the elevation of intraocular pressure (IOP) from 15 mmHg to 80 mmHg for 2 hours. In the hypothermia groups, the rectal temperature was decreased from 38.5 °C to 31.5 °C by using a domestic cooling pad throughout the experiments. Results: Exposure to 80 mmHg of IOP decreased the choroidal blood flow to 40 - 60% of the baseline value. In the young rats, the normalized amplitude of b-wave decreased during ischemia to 60.6±3.0% of the baseline value under normothermic condition and to 70.8±5.3% under hypothermic condition. During reperfusion, the amplitude of the b-wave recovered to the baseline level by ...
The effects of small variations in brain temperature have been tested in a number of stroke and brain injury models. For example, intraischemic hypothermia after transient global ischemia protected the CA1 hippocampus and dorsolateral striatum from neuronal necrosis (142) and attenuated cognitive and sensory motor deficits (143). In dogs, mild hypothermia at 34°C also resulted in significant improvement in neurologic function after cardiac arrest (144). Mild temperature reductions dramatically reduced infarct volume after transient focal ischemia (145, 146), whereas profound temperature reductions (24°C) or extended periods of mild hypothermia were required to reduce infarct volume after permanent focal ischemia (147, 148).. One of the limitations of postischemic hypothermia appears to be the therapeutic window. Although dramatic protection is observed if hypothermia is induced during or immediately after the ischemic insult, lesser degrees of protection are observed as a delay in the ...
Dr. Shankaran is continuing to study the hypothermia therapy. In a study submitted for publication that involves the same two groups of babies, MRIs tend to be more favorable for the hypothermia group, she said. Her team is also looking at variations on how best to use hypothermia. For instance, they are studying whether more time - 120 hours instead of 72 - and a lower temperature - 32 degrees instead of 33.5 - might deliver better results.. Donna Ferriero, MD, the W.H. and Marie Wattis Distinguished Professor and chair of the department of pediatrics at the University of California, San Francisco, said it is not fully understood why hypothermia therapy helps prevent brain injury in babies.. We still dont know the true mechanism at work, she told Neurology Today. We think we are slowing the metabolism and thus ultimately preventing cell death.. Dr. Ferriero was part of a research team that investigated the use of Cool-Cap, a brain-cooling cap that works on the same principle as whole-body ...
In recent years, mild or moderate hypothermia has been proposed for clinical use as an adjunct for achieving protection from cerebral ischemia and traumatic brain injury. Clinically feasible brain cooling methods include a head hood or helmet with chemical cooling, head immersion in ice water, nasophyaryngeal cooling after tracheal intubations, etc. Under normal conditions it has been shown that temperature along the common and internal carotid arteries does not change significantly due to relatively small heat exchange surface of the blood vessels and high flow velocity of the blood. However, when the neck and brain surfaces are cold due to wearing external cooling garments, heat loss from the common and internal carotid arteries may result in arterial blood cooling before the blood enters the Circle of Willis [Zhu 2000]. ...
10 patients received hypothermia, while 9 were normothermic controls. It took an average of 3.5 hours to reach the target temperature of 32º C. In 9 out of 10 patients, the target was overshot, and the entire cooling and rewarming process lasted an average of 47.4 hours. There was a measurable, but non-statistically significant trend (P = 0.14) towards better clinical outcome in the hypothermic group: 50% of the hypothermic patients and 90% of the normothermic patients had bad outcomes. There was also a trend towards reduced infarct volume in the hypothermic cohort. Sinus bradycardia was the only complication to occur with a significantly higher frequency in the hypothermia group than in the control group. Researchers conclude that induced moderate hypothermia in acute ischemic stroke is both feasible and safe. A larger study of poststroke cooling is underway.. ...
Postischemic hypothermia protects against loss of agrin and SPARC from the vascular basement membrane in global cerebral ischemia
Algarni KD, Yanagawa B, Rao V, Yau TM. 2014. Profound hypothermia compared with moderate hypothermia in repair of acute type A aortic dissection. The Journal of Thoracic and Cardiovascular Surgery. 148(6):2888-94. Angeloni E, Melina G, Refice SK, Roscitano A, Capuano F, Comito C, et al. 2015. Unilateral Versus Bilateral Antegrade Cerebral Protection During Aortic Surgery: An Updated Meta-Analysis. The Annals of Thoracic Surgery. 99(6):2024-31. Ariyaratnam P, Loubani M, Griffin SC. 2015. Minimally invasive aortic valve replacement: Comparison of long-term outcomes. Asian Cardiovascular and Thoracic Annals. 23(7):814-21. Candaele S, Herijgers P, Demeyere R, Flameng W, Evers G. 2003. Chest pain after partial upper versus complete sternotomy for aortic valve surgery. ACTA CARDIOL. 58(1):17-21. Guo J, Wang Y, Zhu J, Cao J, Chen Z, Li Z, et al. 2014. Right axillary and femoral artery perfusion with mild hypothermia for aortic arch replacement. J CARDIOTHORAC SURG. 9(1):94. Jiang H, Liu Y, Yang Z, Ge ...
A new study shows how high-dose erythropoietin (EPO) can work together with hypothermia therapy to help babies with hypoxic ischemic encephalopathy (HIE).
OBJECTIVE: Mild hypothermia has a protective effect on ischemic stroke, but the mechanisms remain elusive. Here, we investigated microRNA (miRNA) profiles and the specific role of miRNAs in ischemic stroke treated with mild hypothermia. MATERIALS AND METHODS: Male adult Sprague Dawley rats were subjected to focal transient cerebral ischemia. Mild hypothermia was induced by applying ice packs around the neck and head of the animals. miRNAs expression profiles were detected in ischemic stroke treated with mild therapeutic hypothermia through miRNA chips. Reverse transcription-polymerase chain reaction (RT-PCR) was used to verify the change of miRNA array. Western blot and adenosine triphosphate (ATP) assay kits were used to detect the changes of protein expression and ATP levels, respectively. miR-15b mimic and its control were injected into the right lateral ventricle 60 min before the induction of ischemia. RESULTS: The results showed that mild hypothermia affected miRNAs profiles expression. We ...
Sou SN, Lee K, Nayyar K, Polizzi KM, Sellick C, Kontoravdi Cet al., 2017, Exploring cellular behavior under transient gene expression and its impact on mAb productivity and Fc-glycosylation., Biotechnol Bioeng Transient gene expression (TGE) is a methodology employed in bioprocessing for the fast provision of recombinant protein material. Mild hypothermia is often introduced to overcome the low yield typically achieved with TGE and improve specific protein productivity. It is therefore of interest to examine the impact of mild hypothermic temperatures on both the yield and quality of transiently expressed proteins and the relationship to changes in cellular processes and metabolism. In this study, we focus on the ability of a Chinese hamster ovary cell line to galactosylate a recombinant monoclonal antibody (mAb) product. Through experimentation and flux balance analysis, our results show that TGE in mild hypothermic conditions led to a 76% increase in qP compared to TGE at 36.5°C in our ...
BACKGROUND: This is a phase 4 study of infants registered with the UK TOBY Cooling Register from December 2006 to February 2008. The registry was established on completion of enrolLment to the TOBY randomised trial of treatment with whole body hypothermia following perinatal asphyxia at the end of November 2006. METHODS: We collected information about patient characteristics, condition at birth, resuscitation details, severity of encephalopathy, hourly temperature record, clinical complications and outcomes before hospital discharge. RESULTS: 120 infants born at a median of 40 (IQR 38-41) weeks gestation and weighing a median of 3287 (IQR 2895-3710) g at birth were studied. Cooling was started at a median of 3 h 54 min (IQR 2 h-5 h 32 min) after birth. All but three infants underwent whole body cooling. The mean (SD) rectal temperature from 6 to 72 h of the cooling period was 33.57 degrees C (0.51 degrees C). The daily encephalopathy score fell: median (IQR) 11 (6-15), 9.7 (5-14), 8 (5-13) and 7 (2-12)
The research aims to unravel the mechanisms of the neuroprotective effect of mild hypothermia in animal models of global and focal cerebral ischemia, and to translate the experimental findings to the clinical approach of patients with global and focal cerebral ischemia. For the experimental work, a close collaboration exists with the stroke research unit within the EFAR research group (S. Sarre, R. Kooijman and Y. Michotte). These experimental findings were translated to the clinical approach of patients with global cerebral ischemia (The European Hypothermia Network; The European Consortium of Resuscitative Hypothermia Research) as well as patients with focal cerebral ischemia (Therapeutic hypothermia to improve neurological outcome in ischemie stroke in IWT project 2006-2009).. This translation to clinical practice has been supported by a recent Society of Critical Care Medicine consensus about mild therapeutic hypothermia.. In the near future the focus will be on the search of young ...
hypothermia - MedHelps hypothermia Center for Information, Symptoms, Resources, Treatments and Tools for hypothermia. Find hypothermia information, treatments for hypothermia and hypothermia symptoms.
TY - JOUR. T1 - Pulsatile perfusion improves regional myocardial blood flow during and after hypothermic cardiopulmonary bypass in a neonatal piglet model. AU - Ündar, Akif. AU - Masai, Takafumi. AU - Yang, Shuang Qiang. AU - Eichstaedt, Harald C.. AU - McGarry, Mary Claire. AU - Vaughn, William K.. AU - Fraser, Charles D.. PY - 2002/1/1. Y1 - 2002/1/1. N2 - Pediatric myocardial related morbidity and mortality after cardiopulmonary bypass (CPB) are well documented, but the effects of pulsatile perfusion (PP) versus nonpulsatile perfusion (NPP) on myocardial blood flow during and after hypothermic CPB are unclear. After investigating the effects of PP versus NPP on myocardial flow during and after hypothermic CPB, we quantified PP and NPP pressure and flow waveforms in terms of the energy equivalent pressure (EEP) for direct comparison. Ten piglets underwent PP (n = 5) or NPP (n = 5). After initiation of CPB, all animals underwent 15 minutes of core cooling (25°C), 60 minutes of hypothermic CPB ...
TY - JOUR. T1 - Effect of mild hypothermia on ischemia-induced release of neurotransmitters and free fatty acids in rat brain. AU - Busto, Raul. AU - Globus, Mordecai Y.T.. AU - Dietrich, W. Dalton. AU - Martinez, Elena. AU - Valdes, Isabel. AU - Ginsberg, Myron D.. N1 - Copyright: Copyright 2017 Elsevier B.V., All rights reserved.. PY - 1989/7. Y1 - 1989/7. N2 - We have demonstrated previously that mild intraischemic hypothermia confers a marked protective effect on the final histopathological outcome. The present study was carried out to evaluate whether this protective effect involves changes in the degree of local cerebral blood flow reductions, tissue accumulation of free fatty acids, or alterations in the extracellular release of glutamate and dopamine. Rats whose intraischemic brain temperature was maintained at 36°C, 33°C, or 30°C were subjected to 20 minutes of ischemia by four-vessel occlusion combined with systemic hypotension. Levels of local cerebral blood flow, as measured ...
Prospective randomized trial of normothermic versus hypothermic cardiopulmonary bypass on cognitive function after coronary artery bypass graft surgery.
TY - JOUR. T1 - Cerebral blood flow during low-flow hypothermic cardiopulmonary bypass in baboons. AU - Schwartz, A. E.. AU - Kaplon, R. J.. AU - Young, W. L.. AU - Sistino, J. J.. AU - Kwialkowski, P.. AU - Michler, R. E.. PY - 1994/1/1. Y1 - 1994/1/1. N2 - Background: Neurologic injury after cardiopulmonary bypass (CPB) is a frequent and devastating complication of cardiothoracic surgery. Disordered cerebral hemodynamics during CPB has been implicated as an important factor in the etiology of these injuries. Evidence of disordered cerebral hemodynamics includes reports of a progressive time-dependent decrease in cerebral blood flow (CBF) during stable full-flow CPB. Low-flow hypothermic CPB has become a preferred technique for the management of pediatric patients undergoing surgical repair of complex cardiac lesions. Because CBF is already substantially reduced with the onset of low-flow CPB, we determined if a similar progressive decline in CBF occurs during the low-flow state. Methods: After ...
Objective: We assessed the causes of imbalance of oxygen transport by continuously measuring oxygen consumption (VO2) during hypothermic cardiopulmonary bypass (CPB) in pigs. Methods: Six pigs (17.2±1.6 kg) underwent hypothermic (32°C) CPB for 180 min with 120 min of aortic crossclamping (ACC). An AMIS 2000 mass spectrometer was adapted for the on-line measurement of VO2. Arterial lactate was measured at the beginning of CPB, the end of hypothermia, before and 10 min after ACC release, 20 min later, and at the end of CPB. Results: Arterial lactate increased from 1.8±0.7 to 5.1±1.8 mmol/L during CPB. Hypothermia reduced VO2 by 0.63±0.29 ml/min/kg per °C, but lactate increased to 4.2±1.5 mmol/L ( ...
DISCUSSION. This study reports on a three-year experience of administering hypothermia therapy to asphyxiated newborns in a tertiary-level university hospital. The criteria for infant inclusion and exclusion were based on previous studies on safety. The gestational age for inclusion in the study (more than 35 weeks) made it possible to differentiate encephalopathy attributed to perinatal hypoxia from other problems relating to prematurity.17 Hypothermia is applied within the first six hours of life because this is the therapeutic window within which the neu-roprotective effect relating to reduction of cerebral metabolism, reduction of excitatory neurotransmitter activity, suppression of free radical release, inhibition of the apoptotic process and reduction of the release of inflammatory mediators is most effective. In general, the efficacy of the neuroprotective effect diminishes if the cooling period starts after the therapeutic window, but evidence suggests that the neurological injury in HIE ...
TY - JOUR. T1 - Hypoxia-Ischemia and Hypothermia Independently and Interactively Affect Neuronal Pathology in Neonatal Piglets with Short-Term Recovery. AU - OBrien, Caitlin E.. AU - Santos, Polan T.. AU - Kulikowicz, Ewa. AU - Reyes, Michael. AU - Koehler, Raymond C.. AU - Martin, Lee J.. AU - Lee, Jennifer K.. PY - 2019/9/1. Y1 - 2019/9/1. N2 - Therapeutic hypothermia is the standard of clinical care for moderate neonatal hypoxic-ischemic encephalopathy. We investigated the independent and interactive effects of hypoxia-ischemia (HI) and temperature on neuronal survival and injury in basal ganglia and cerebral cortex in neonatal piglets. Male piglets were randomized to receive HI injury or sham procedure followed by 29 h of normothermia, sustained hypothermia induced at 2 h, or hypothermia with rewarming during fentanyl-nitrous oxide anesthesia. Viable and injured neurons and apoptotic profiles were counted in the anterior putamen, posterior putamen, and motor cortex at 29 h after HI injury ...
Hypothermia improves survival and neurodevelopment in newborns with moderate to severe HIE.Total body cooling and selective head cooling are effective methods in treating newborns with HIE. Clinicians should consider offering therapeutic hypothermia as part of routine clinical care to these newborns …
TY - JOUR. T1 - Ontogeny of a surgical technique. T2 - Robotic kidney transplantation with regional hypothermia. AU - Sood, Akshay. AU - McCulloch, Peter. AU - Dahm, Philipp. AU - Ahlawat, Rajesh. AU - Jeong, Wooju. AU - Bhandari, Mahendra. AU - Menon, Mani. N1 - Publisher Copyright: © 2015 IJS Publishing Group Limited. Copyright: Copyright 2017 Elsevier B.V., All rights reserved.. PY - 2016/1/1. Y1 - 2016/1/1. N2 - Introduction: Innovation is a hallmark of surgical practice. It is generally accepted that a new procedure will undergo technical changes during its evolution; however, quantitative accounts of the process are limited. Methods: Multiple groups, including our own, have recently described a minimally-invasive approach to conventional kidney transplantation (KT) operation. Unique to our experience is a structured development of the technique within the confines of a safe surgical innovation framework - the IDEAL framework (idea, development, exploration, assessment, long-term ...
In this dissertation, two treatments, intraischemic hypothermia and glutamate receptor blockade, were evaluated for neuroprotective efficacy against global ischemia. Since the standard assessment of ischemic damage using only histological outcome reveals nothing about function, I used multiple outcome measures including behaviour and electrophysiology, as well as a histological evaluation. In order to further increase the strength of this approach, multiple assessments were made in the same animals. -- Intraischemic hypothermia induced by selectively cooling the brain conveyed both long-lasting protection against functional loss as well as cell loss. These findings provide a strong argument for the implementation of hypothermia in cases where the occurrence of an ischemic episode can be predicted before it occurs (e.g. elective cardiac/neuro-surgery). However, most cases of ischemia, or stroke, occur without warning thereby precluding the use of intraischemic hypothermia. -- NBQX, a glutamate ...
TY - JOUR. T1 - Neonatal neurobehavioral abnormalities and MRI brain injury in encephalopathic newborns treated with hypothermia. AU - Coleman, Maya B.. AU - Glass, Penny. AU - Brown, Judy. AU - Kadom, Nadja. AU - Tsuchida, Tammy. AU - Scafidi, Joseph. AU - Chang, Taeun. AU - Vezina, Gilbert. AU - Massaro, An N.. PY - 2013/9/1. Y1 - 2013/9/1. N2 - Background: Neonatal Encephalopathy (NE) is a prominent cause of infant mortality and neurodevelopmental disability. Hypothermia is an effective neuroprotective therapy for newborns with encephalopathy. Post-hypothermia functional-anatomical correlation between neonatal neurobehavioral abnormalities and brain injury findings on MRI in encephalopathic newborns has not been previously described. Aim: To evaluate the relationship between neonatal neurobehavioral abnormalities and brain injury on magnetic resonance imaging (MRI) in encephalopathic newborns treated with therapeutic hypothermia. Study design: Neonates with hypoxic ischemic encephalopathy ...
Hypothermia happens when someones body temperature drops below 35°C (95°F). Normal body temperature is around 37°C (98. 6°F). Hypothermia can become life-threatening quickly, so its important to treat someone with hypothermia straight away. Severe hypothermia, when the body temperature falls below 30°C (86°F), is often fatal. When your body temperature drops,your heart,nervous system and other organs cant work normally. Left untreated, hypothermia can eventually lead to complete failure of your heart and respiratory system and to death. Hypothermia is usually caused by being in a cold environment for a long time. This could be from staying outdoors in cold conditions, falling into cold water, or from living in a poorly heated house. Elderly people, babies, homeless people and anyone who is thin and frail or not able to move around easily are particularly vulnerable. Shivering is likely the first thing youll notice as the temperature starts to drop because its your bodys automatic defense
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The induction of a mild reduction in body core temperature has been demonstrated to provide neuroprotection for patients who have suffered a medical event resulting in ischemia to the brain or vital organs. Temperatures in the range of 32-34 °C provide the required level of protection and can be produced and maintained by diverse means for periods of days. Rewarming from hypothermia must be conducted slowly to avoid serious adverse consequences and usually is performed under control of the thermal therapeutic device based on a closed-loop feedback strategy based on the patients core temperature. Given the sensitivity and criticality of this process, it is important that the device control system be able to interact with the human thermoregulation system, which itself is highly nonlinear. The therapeutic hypothermia device must be calibrated periodically to ensure that its performance is accurate and safe for the patient. In general, calibration processes are conducted with the hypothermia ...
TY - JOUR. T1 - Prior hypothermia attenuates malignant hyperthermia in susceptible swine. AU - Iaizzo, Paul A.. AU - Kehler, Chris H.. AU - Carr, Richard J.. AU - Sessler, Daniel I.. AU - Belani, Kumar G.. PY - 1996/4/19. Y1 - 1996/4/19. N2 - This study was designed to determine the extent by which mild or moderate hypothermia attenuates the triggering of malignant hyperthermia (MH) induced by the combined administration of halothane and succinylcholine. Sixteen susceptible swine were initially anesthetized with nontriggering drugs and then either kept normothermic (≃38°C, n = 6) or cooled to induce mild (≃35°C, n = 6), or moderate (≃33°C, n = 4) hypothermia. Next, after a 30- min control period, the normothermic and mildly hypothermic animals were administered 1 minimum alveolar anesthetic concentration (MAC) halothane followed by a bolus dose of succinylcholine (2 mg/kg). Within 10 min all normothermic animals developed fulminant MH, whereas the onset of MH was slowed or was absent in ...
Bruno Mourvillier, MD, of the Université Paris Diderot, Sorbonne Paris Cité, Paris, and colleagues conducted a study to examine whether treatment with hypothermia would improve the functional outcome of comatose patients with bacterial meningitis compared with standard care.  Among adults with bacterial meningitis, the death rate and frequency of neurologic complications are high, indicating the need for new therapeutic approaches. Clinical trials of patients with trauma who were treated with hypothermia have shown a decrease of intracranial pressure, suggesting a potential benefit of this technique in bacterial meningitis, according to background information in the article.  The randomized trial conducted in 49 intensive care units in France between February 2009 and November 2011 assessed 130 patients for eligibility and randomized 98 comatose adults with community acquired bacterial meningitis to the hypothermia group, where patients received a loading dose of 39°F cold saline and
Whole-body hypothermia reduces the risk of death or disability in infants with moderate or severe hypoxic ischemic encephalopathy
Anemia Drug May Help Babies at High-Risk of Brain Injury. Anemia Drug May Help Babies at High-Risk of Brain Injury A new study suggests that babies born with hypoxic-ischemic encephalopathy (HIE) that were treated with erythropoietin, a synthetic version of the hormone that stimulates red blood cell production, experienced lesser brain injuries. Researchers indicate that erythropoietin infusions coupled with hypothermia treatment contributed to fewer incidents of brain injury, […]. ...
We have evaluated the effects of varying degrees and durations of hypothermia, combined with anesthesia, on pregnant rats of the Sherin Wistar Strain. Moderate (surgical) and intermediate hypothermia, with ether anesthesia, were safe for both fetus and mother. With pentobarbital anesthesia, however, there were harmful effects, depending on the depth and duration of hypothermia; moderate hypothermia increased fetal and maternal mortality. The combination of CO₂ narcosis and deep hypothermia induced no ill effects.
Therapeutic hypothermia is already widely acknowledged as an effective neuroprotective intervention, especially within the acute care setting in relation to conditions such as cardiac arrest and neonatal encephalopathy. Its multifactorial mechanisms of action, including lowering metabolic rate and reducing acute inflammatory cellular processes, ultimately provide protection for central nervous tissue from continuing injury following ischaemic or traumatic insult. Its clinical application within acute traumatic spinal cord injury would therefore seem very plausible, it having the potential to combat the pathophysiological secondary injury processes that can develop in the proceeding hours to days following the initial injury. As such it could offer invaluable assistance to lessen subsequent sensory, motor and autonomic dysfunction for an individual affected by this devastating condition. Yet research surrounding this interventions applicability in this field is somewhat lacking, the majority ...
Temelkovska, Aleksandra and Kajevski, I and Hristov, Nikola and Mitrev, Zan (2010) Surgery for acute aortic dissection using moderate hypothermia and antegrade cerebral perfusion via the right subclavian artery. . (Unpublished) ...
Experts in Discussion about @NEJM Ask the Authors & Experts: Original Research - Therapeutic Hypothermia in Deceased Organ Donors and Kidney-Graft Function
article{f8148d83-783e-4da1-816a-c12a7ad72203, abstract = {,p,The expression of the mRNAs of nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), neurotrophin 3 (NT3) and the neurotrophin receptor, TrkB, was studied in the rat hippocampus by in situ hybridization following normothermic (37°C) and protective hypothermic (33°C) transient cerebral ischemia of 15 min duration. In the resistant dentate gyms, normothermic ischemia transiently induced NGF mRNA at around 8 h of recovery, while the NT3 mRNA levels were depressed over at least a 24-h recovery period. The levels of BDNF and TrkB were transiently and markedly elevated with a maximal expression at 24 h of recovery. Intraischemic hypothermia reduced the induction of NGF mRNA, while the increase of BDNF mRNA expression occurred earlier during recovery, and the post-ischemic NT3 mRNA depression was not affected. Also, the expression of TrkB mRNA was enhanced, and occurred concomitantly with the elevation of BDNF mRNA. In ...
Adequate preservation of renal allografts for transplantation is important for maintaining and improving transplant outcomes. There are two prevalent methods: hypothermic machine perfusion and static cold storage. The preferred method of storage, however, remains controversial. The objective was to review systematically the evidence comparing outcomes from these two modalities. ...
Treatment of mild Hypothermia - rewarm as soon as possible by any convenient means (eat, drink, put on more clothes, run around)!. Profound Hypothermia - this is a medical emergency. Your body temperature has fallen below 90F (32C) and you are incapable of rewarming yourself. At this stage your brain begins to cool and ceases to function normally. You are at risk of ventricle fibrillation (i.e., heart attack) if your friends rough handle you, re-warm you too quickly or cause you to physically exert yourself! Dont let yourself get this cold!. Frostbite - the freezing of body tissue. Frostbite is caused by sub-freezing temperatures in combination with vasoconstriction - reduced circulation to the extremities. Dehydration, certain drugs (including caffeine, nicotine and THC), hypothermia, and constrictive (tight) clothing or boots, and genetic disposition all contribute to poor circulation.. Avoid contact with metal objects and liquids such as fuels and alcohol that are super cooled (below ...
OBJECTIVE: To evaluate the value of continuous electroencephalography in early prognostication in patients treated with hypothermia after cardiac arrest.. DESIGN: Prospective cohort study.. SETTING: Medical intensive care unit.. PATIENTS: Sixty patients admitted to the intensive care unit for therapeutic hypothermia after cardiac arrest.. INTERVENTION: None.. MEASUREMENTS AND MAIN RESULTS: In all patients, continuous electroencephalogram and daily somatosensory evoked potentials were recorded during the first 5 days of admission or until intensive care unit discharge. Neurological outcomes were based on each patients best achieved Cerebral Performance Category score within 6 months. Twenty-seven of 56 patients (48%) achieved good neurological outcome (Cerebral Performance Category score 1-2).At 12 hrs after resuscitation, 43% of the patients with good neurological outcome showed continuous, diffuse slow electroencephalogram rhythms, whereas this was never observed in patients with poor ...
Postoperative hypothermia increases the incidence of ischaemic cardiac events in patients at risk, but the underlying mechanism is unclear. One possibility is increased cardiac work related to the sympathoneural or adrenomedullary hormonal responses. In awake human volunteers, the present study assessed the effects of mild core hypothermia on these responses, and on the associated changes in indices of cardiac work. A total of 11healthy men were studied on two separate days. On one day, core temperature (Tc) was decreased by the intravenous infusion of cold normal saline (4°C; 60ml/kg over 30min) through a central venous catheter. On the other day (normothermic control), warm normal saline (37°C; 60ml/kg over 30min) was given intravenously. Transthoracic echocardiograms, the sympathoneural response (noradrenaline) and the adrenomedullary response (adrenaline) were evaluated before, during and after the intravenous infusions. Echocardiography was used to measure left ventricular function and ...
We performed a prospective observational (noninterventional) study of hypothermia blanket use in a population of adult intensive care unit patients with body temperatures of ⩾102.5°F. Thirty-nine of ninety-four febrile episodes (in 83 patients) were treated with hypothermia blankets. Logistic regression revealed that the strongest independent predictors of hypothermia blanket use were a temperature of ⩾103.5°F (odds ratio [OR] = 17), mechanical ventilation (OR = 25), and acute central nervous system illness (OR = 7.5). Hospitalization in the medical intensive care unit was strongly associated with avoidance of this therapy (OR = 0.023). Treatment with a hypothermia blanket was ordered by a physician in only 15% of cases. The mean cooling rate was the same (0.028°F/h) for blanket-treated and control patients. Multivariate Cox regression and factorial and repeated measures of analysis of variance revealed that blanket treatment was not more effective than other cooling methods. However, ...
Deep hypothermia, which is used during thoracic aortic surgery for neuroprotection, is associated with coagulation abnormalities in animal and in vitro models. However, there is a paucity of data regarding the impact of deep hypothermia duration on perioperative bleeding. The objective of the current study was to examine the relationship between the duration of deep hypothermia and perioperative bleeding. A retrospective review of 507 consecutive thoracic aortic surgery patients who had surgery with deep hypothermic circulatory arrest was performed. The degree of bleeding and coagulopathy was estimated using perioperative transfusion. Log linear modeling with Poisson regression was used to analyze the relationship between deep hypothermia duration and perioperative bleeding, while controlling for other preselected variables. There was a significant association between deep hypothermia duration and RBC transfusion (P = 0.001). There was no significant association between deep hypothermia duration ...
The results of this investigation demonstrate that a 2°C to 3°C reduction in intraischemic brain temperature is associated with potentially important alterations in ischemic brain metabolism and subsequent partial neuroprotection in comparison to animals studied under normothermic conditions. As indicated by the group effect, intraischemic modest hypothermia resulted in higher pHi values consistently during ischemia and for at least 30 minutes after ischemia compared with normothermic animals. Although the magnitude of difference in pHi between groups is in the order of 0.15 to 0.20 pH units, the persistence of this finding during an interval of approximately 45 minutes may be critical in attenuating potential adverse effects of brain acidosis. Among animals of both groups, clinical and histological evidence of brain injury were associated with more severe intraischemic acidosis. The results suggest that brain acidosis may be critical in the pathogenesis of neonatal ischemic brain damage, and ...
Hypothermia and frostbite are significant dangers when cold temperatures set in. The two conditions are somewhat related, but have different symptoms. Its important to know the warning signs for both, and the steps you can take to prevent and treat them. Hypothermia Hypothermia is the condition in which your core body temperature falls below what it needs to be at in order to function properly. The average body temperature of humans is around 98.6 degrees F. When you are exposed to cold temperatures, your body loses more heat than it can produce, which makes your nervous system, heart, and other organs not function properly. If the body falls below 95 degrees F, medical attention is needed. The signs of hypothermia include shivering, mental confusion, exhaustion, slurred speech, low energy, pale skin, a lowering heart and respiratory rate, and more. If you see anyone experiencing any of these, take their temperature. If it is below 95 degrees F, seek medical attention immediately. If medical care is
An Hypothermia is defined as a decrease in core temperature below 35 degrees C. The well-described deleterious effects of accidental hypothermia on outcome in multiple-trauma patients contrast the beneficial effect of controlled hypothermia on organ function during ischemia in elective surgery. Experimental studies have shown that induced hypothermia during hemorrhagic shock might have beneficial effects on outcome. The beneficial effects of induced hypothermia appear to be partly mediated by the prolongation of the golden hour with prevention of hypoxic organ dysfunction. However, hypothermia also has been thought to have an impact on the immunologic response after trauma and elective surgery. Induction of hypothermia seems to decrease the release of pro-inflammatory cytokines believed to influence distant organ damage positively, and is mediated by the interaction of polymorphonuclear leucocytes (PMNL) and capillary endothelial cells. Nevertheless, the incidence of posttraumatic infectious ...
Inadvertent perioperative hypothermia is a phenomenon that can occur as a result of the suppression of the central mechanisms of temperature regulation due to anaesthesia, and of prolonged exposure of large surfaces of skin to cold temperatures in operating rooms. Inadvertent perioperative hypothermia has been associated with clinical complications such as surgical site infection and wound-healing delay, increased bleeding or cardiovascular events. One of the most frequently used techniques to prevent inadvertent perioperative hypothermia is active body surface warming systems (ABSW), which generate heat mechanically (heating of air, water or gels) that is transferred to the patient via skin contact. To assess the effectiveness of pre- or intraoperative active body surface warming systems (ABSW), or both, to prevent perioperative complications from unintended hypothermia during surgery in adults. We searched the Cochrane Central Register of Controlled Trials (CENTRAL; Issue 9, 2015); MEDLINE ...
Frostbite is a severe reaction to cold exposure that can permanently damage its victims. A loss of feeling and a white or pale appearance in fingers, toes, or nose and ear lobes are symptoms of frostbite.. Hypothermia is a condition brought on when the body temperature drops to less than 90 degrees Fahrenheit. Symptoms of hypothermia include uncontrollable shivering, slow speech, memory lapses, frequent stumbling, drowsiness, and exhaustion.. If frostbite or hypothermia is suspected, begin warming the person slowly and seek immediate medical assistance. Warm the persons trunk first. Use your own body heat to help. Arms and legs should be warmed last because stimulation of the limbs can drive cold blood toward the heart and lead to heart failure.. Put person in dry clothing and wrap their entire body in a blanket.. Never give a frostbite or hypothermia victim something with caffeine in it (like coffee or tea) or alcohol. Caffeine, a stimulant, can cause the heart to beat faster and hasten the ...
Four hours and 13 minutes into the January race, Dixon suffered a seizure just 25 yards from the finish line. A medical team rushed her off the course, and she was taken to St. Lukes Episcopal Hospital by Life Flight. On Tuesday evening at Memorial Park, in front of her running buddies and TV cameras, Dixon ran those last 25 yards. When Dixon went into cardiac arrest, race officials notified Mulvihill that one of his team members was hospitalized. At St. Lukes, doctors used hypothermia treatment to lower her body temperature and prevent brain damage. Dixon was diagnosed with a congenital coronary anomaly; the left main artery pumping blood to her heart was on the wrong side.
You can survive in 78deg water for a very long time, and most of the people on board swam to the shore quite quickly, and the rescuers came on the scene promptly.. Some people can survive in 78F water for a prolonged period of time, while other people in poor physical condition and/or having just suffered physical trauma often may not. The SST (Sea Surface Temperature) of 77-78°F was low enough to eventually bring about a lowering of body core temperature to the range for mild hypothermia at 90-95°F, moderate hypothermia at 82-90°F, or even severe hypothermia at 68-82°F. Trauma suffered when the aircraft ditched in the sea could very well have contributed to a more rapid onset of hypothermia as the heart rate, blood pressure, and respiratory rated dropped. Under such conditions, especially in the presence of aggravated hypoglycemia or hyperglycemia, you can see heart problems become a risk for fatality.. It is untrue to say, most of the people on board swam to the shore quite quickly. ...
OBJECTIVE Selective antegrade cerebral perfusion (SACP) seems to be associated with a better outcome compared to hypothermic circulatory arrest (HCA) alone. This study was undertaken to evaluate the influence of different SACP temperatures on the neurological integrity. METHODS Twenty-six pigs were included in the study and assigned to 100 min HCA at 20 degrees C body temperature without (n = 6) or with either 10 degrees C (n = 6), 20 degrees C (n = 7) or 30 degrees C (n = 7) of SACP. Haemodynamics, metabolics and neurophysiology (EEG, SSEP, ICP, sagittal sinus saturation) were monitored. Animals were sacrified 4h after reperfusion and brains perfused for histological and molecular genetic assessment. RESULTS There were no clinically relevant differences in haemodynamics between groups. The rise in ICP during SACP was significantly more marked in the 30 degrees C group (p | 0.05) and remained high during the entire experiment. In the 10 degrees C group the rise in ICP was postponed, but increased
The anaesthetic records of 1525 dogs were examined to determine the prevalence of postanaesthetic hypothermia, its clinical predictors and consequences. Temperature was recorded throughout the anaesthesia. At the end of the procedure, details coded in were: hyperthermia (,39.50°C), normothermia (38.50°C-39.50°C), slight (38.49°C-36.50°C), moderate (36.49°C-34.00°C) and severe hypothermia (,34.00°C). Statistical analysis consisted of multiple regression to identify the factors that are associated with the temperature at the end of the procedure. Before premedication, the temperature was 38.7 ± 0.6°C (mean ± sd). At 60, 120 and 180 minutes from induction, the temperature was 36.7 ± 1.3°C, 36.1 ± 1.4°C and 35.8 ± 1.5°C, respectively. The prevalence of hypothermia was: slight, 51.5 per cent (95 per cent CI 49.0 to 54.0 per cent); moderate, 29.3 per cent (27.1-31.7 per cent) and severe: 2.8% (2.0-3.7%). The variables that associated with a decrease in the temperature recorded at the ...
Any victim pulled from cold water should be treated for hypothermia - this is the very dangerous and important stage of survival which is a result of cold water immersion. At this point, you should seek trained medical treatment immediately. Symptoms of hypothermia may include intense shivering, loss of coordination, mental confusion, cold and blue (cyanotic) skin, weak pulse, uncontrolled breathing, irregular heartbeat, and enlarged pupils. Once shivering stops, core body temperature begins to drop critically. Try to prevent body cooling and get the victim to a medical facility immediately.. ...
We ve all used ice packs on sprains, strains and stings to alleviate discomfort. Cryotherapy in one form or another has probably existed since early humans first encountered snow and ice. Documents from ancient Egypt report the use of medicinal cold therapy. Battlefield surgeons under Napoleon used cold to anesthetize limbs prior to amputation. Intentional systemic hypothermia or therapeutic hypothermia was first documented in modern times in 1943. Dr. Fay described human refrigeration as a treatment to slow rapidly spreading cancer cells and control pain.
IDENTIFYING HYPOTHERMIA When it is exposed to cold, the body kicks into action to produce heat. It does this by the use of muscle actions as the core cools. Muscles shiver to produce heat and are a warning that you need to warm up. As hypothermia worsens, more symptoms will become apparent. Aside from shivering, the most noticeable symptoms of hypothermia will be related to mental status. The person might appear confused, uncoordinated and lethargic.. The victims speech becomes slurred, and they often appear uninterested in helping themselves. All this occurs as a result of the effect of cooling temperatures on the brain: The colder the body core gets, the slower the brain works. Other organs begin to shut down, and the victim loses consciousness. Any unconscious person you find exposed to cold weather should be considered hypothermic until proven otherwise.. Cold-related tissue effects also include local damage, such as frostbite. Frostbite affects areas such as the fingers, toes, nose, ...
Therapeutic hypothermia is indicated for infants with moderate-to-severe hypoxic-ischemic encephalopathy (HIE). Supportive management is also critical to prevent additional injury from seizure activit... more
TY - JOUR. T1 - Thermoregulate, autoregulate and ventilate. T2 - Brain-directed critical care for pediatric cardiac arrest. AU - Kurz, Jonathan. AU - Smith, Craig Martin. AU - Wainwright, Mark. PY - 2017/6/1. Y1 - 2017/6/1. N2 - Purpose of review Cardiac arrest in childhood is associated with a high risk for mortality and poor long-term functional outcome. This review discusses the current evidence for neuroprotective therapies and goals for postarrest care in the context of the pathophysiology of hypoxic-ischemic injury, modalities for neurologic prognostication in these children and potential future monitoring paradigms for maximizing cerebral perfusion in the postarrest period. Recent findings The recent publication of the in-hospital and out-of-hospital Therapeutic Hypothermia After Cardiac Arrest trials demonstrated a lack of statistically significant benefit for the use of postarrest therapeutic hypothermia. As a result, targeted normothermic temperature management has become standard of ...
TY - JOUR. T1 - Independent contributions of hypothermia and acidosis to coagulopathy in swine. AU - Martini, Wenjun Z.. AU - Pusateri, Anthony E.. AU - Uscilowicz, John M.. AU - Delgado, Angel V.. AU - Holcomb, John B.. AU - Tyburski, James G.. AU - Rhee, Peter M.. AU - Schreiber, Martin A.. PY - 2005/5. Y1 - 2005/5. N2 - Background: Clinical coagulopathy occurs frequently in the presence of acidosis and hypothermia. The purpose of this study was to determine the relative contributions of acidosis and hypothermia to coagulopathy, as measured by current standard bedside and clinical laboratory analyses (i.e., bleeding time and prothrombin time). In addition, we investigated possible mechanisms of these effects using a modified prothrombin time test, thromboelastography, and thrombin kinetics analyses. An improved understanding of coagulopathy should facilitate hemorrhage control. Methods: Twenty-four pigs were randomly allocated into normal (pH, 7.4; 39°C), acidotic (pH, 7.1; 39°C), ...
Bessell, J; Ludbrook G; Millard S; Baxter P; Ubhi S; Maddern G (1999). "Humidified gas prevents hypothermia induced by ... Bessel, J; Karatassas A; Patterson J; Jamieson G; Maddern G (1995). "Hypothermia induced by laparoscopic insufflation. A ... Surgical hypothermia, defined as a core temperature below 36.0 °C, is associated with increased risk of infectious and non- ... Barring preventive interventions, hypothermia occurs in more than half of all surgical patients undergoing anesthesia. The risk ...
Non-invasively induced therapeutic hypothermia has been shown to reduce mortality of successfully resuscitated cardiac arrest ... McKean, Staci (2009). "Induced Moderate Hypothermia After Cardiac Arrest". AACN Advanced Critical Care. 20 (4): 342-53. doi: ... It is a non-invasive precision temperature management system that is used to induce hypothermia in comatose patients that have ... Therapeutic hypothermia, which lowers the patient's body temperature to levels between 32-34 °C (90-93 °F), is used to help ...
Inducing hypothermia or heat injury; Conducting mock executions; Depriving the detainee of necessary food, water, sleep, or ... The manuals describe coercive techniques to be used "to induce psychological regression in the subject by bringing a superior ... Lawg.org Archived 2006-04-19 at the Wayback Machine JPRA Operational Concerns Over Application of Various Means of Induced ...
"Induced Hypothermia During Emergency Department Thoracotomy: an Animal Model. Journal of Trauma Injury and Critical Care. 48: ... Induced Hypothermia During Emergency Department Thoracotomy: an Animal Model. Journal of Trauma Injury and Critical Care. 48: ...
It induces a variety of effects, including analgesia, hypothermia and increased locomotor activity. It is also involved in ... Neurotensin is an endogenous neuropeptide involved in thermoregulation that can induce hypothermia and neuroprotection in ... "Neurotensin-induced hypothermia improves neurologic outcome after hypoxic-ischemia". Crit. Care Med. 32 (3): 806-10. doi: ...
Cappuccino's use of induced hypothermia garnered national headlines for the technique. Cappuccino received a dual BES degree ... "Acuity Care Technology - Article - Induced Hypothermia Shows Promise in Treating Cardiac, Neurotrauma Patients". Retrieved 2008 ...
Hypothermia induces a "cold diuresis" which can lead to electrolyte abnormalities - specifically hypokalemia, hypomagnesaemia, ... It appears that regardless of the technique used to induce hypothermia, people begin to shiver when temperature drops below ... There are a number of methods through which hypothermia is induced. These include: cooling catheters, cooling blankets, and ... Polderman, Kees H (2008). "Induced hypothermia and fever control for prevention and treatment of neurological injuries". The ...
Hypothermia Thermoregulation Axon reflex Raynaud's syndrome Daanen, H.A.M. (2003). "Finger cold-induced vasodilation: a review ... This cold-induced vasodilation increases blood flow and subsequently the temperature of the fingers. A new phase of ...
CS1 maint: discouraged parameter (link) Bushak, Lecia (December 20, 2014). "Induced Hypothermia: How Freezing People After ... "profound hypothermia" is then medically induced, at temperatures as low as 50 F (10 C). According to Becker, "draining the ... Cell death can be delayed or stopped through the application of therapeutic hypothermia. In the case of Swedish skier Anna ...
It is important to note that induced mild hypothermia, between temperatures of 33 °C and 36 °C is effective whilst safer than ... Council, National Research (1955). Physiology of Induced Hypothermia: Proceedings of a Symposium, 28-29 October 1955. doi: ... Hypothermia also has a significant therapeutic role, the technique of therapeutic hypothermia involves deliberate reduction of ... Hypothermia is defined as having a core body temperature below 35 °C (or 95 °F). Under 35 °C, the body loses more heat than it ...
This induced hypothermia technique is beginning to be used in emergency medicine. The combination of mildly reducing body ... 1990). "Moderate hypothermia after cardiac arrest of 17 minutes in dogs. Effect on cerebral and cardiac outcome". Stroke. ... 1990). "Mild cerebral hypothermia during and after cardiac arrest improves neurologic outcome in dogs". Journal of Cerebral ... 1990). "Accidental deep hypothermia with cardiopulmonary arrest: extracorporeal blood rewarming in 11 patients". European ...
Trauma-induced coagulopathy is acutely worsened by the presence of acidosis and hypothermia. The activity of coagulation ... Hypothermia (less than 34 C) compounds coagulopathy by impairing coagulation and is an independent risk factor for death in ... The "lethal triad" of ways trauma can lead to death is acidosis, hypothermia, and coagulopathy. It is possible for trauma to ... However, this traditional model of trauma-induced coagulopathy may be too limited. Further studies have shown that a degree of ...
In mice, I-RTX induces dose-dependent hypothermia in vivo. A statistically significant difference was reported at doses > 0.1 ... "5-Iodoresiniferatoxin evokes hypothermia in mice and is a partial transient receptor potential vanilloid 1 agonist in vitro". ...
Hypothermia[edit]. The human body is at risk of accidentally induced hypothermia when large amounts of cold fluids are infused ...
... in that hypothermia is induced. However, the purposes and procedures of EPR differ from DHCA. DHCA induces hypothermia to aid ... The trial procedure involves rapidly inducing profound hypothermia (10 °C) with an aortic flush in trauma victims that have ... EPR uses hypothermia, drugs, and fluids to "buy time" for resuscitative surgery. If successful, EPR may someday be deployed in ... Twilley, Nicola (21 November 2016). "Can Hypothermia Save Gunshot Victims?". The New Yorker. Retrieved 23 January 2018. Kaplan ...
"Evaluation of hypothermia-induced analgesia and influence of opioid antagonists in Leopard frogs (Rana pipiens)". Pharmacology ... "The role of pH and osmolarity in evoking the acetic acid-induced wiping response in a model of nociception in frogs". Brain ... "Hypothermia is also unacceptable as a sedation technique for painful procedures". Veterinary articles have been published ...
If the solutions administered are colder than the temperature of the body, induced hypothermia can occur. If the temperature ... "Warming of intravenous and irrigation fluids for preventing inadvertent perioperative hypothermia". Cochrane Database of ...
purge To press the purge button on a demand valve to induce a gas flow which is intended to clear the demand valve interior of ... hypothermia A lowering of core body temperature, usually due to heat loss. hypoxia Abnormally low tissue oxygen concentration: ... Usually induced by pre-dive hyperventilation. Also referred to as shallow water blackout, which is an ambiguous term constant ... Used for dry suits and hot water suits which are less affected by depth induced buoyancy changes. compression The process of ...
Collaborated with medical manufacturer Benechill on its new Rhinochill system, which induces therapeutic hypothermia during ...
... on apomorphine-induced hypothermia in mice". Psychopharmacology. 88 (2): 240-6. doi:10.1007/BF00652248. PMID 3006113. McConathy ...
In traumatic brain injury, induced hypothermia may reduce the risks of mortality, poor neurologic outcome in adults. However, ... Radiation-induced brain edema (RIBE) is a potentially life threatening complication of brain tissue radiation and is ... In children with traumatic brain injury, there was no benefit to therapeutic hypothermia and increased the risk of mortality ... Pretreatment with a sedative agent and neuromuscular blocking agent to induce unconsciousness and motor paralysis has been ...
Reversal of reserpine-induced hypothermia by a drug is a classical test for potential anti-depressant properties. A selective ... In mice pre-treated with reserpine, an oral dose of 0.3 mg/kg d-synephrine significantly reversed the hypothermia, while l- ... Barrett M., Orchard I. (1990). "Serotonin-induced elevation of cAMP levels in the epidermis of the blood-sucking bug, Rhodnius ... Synephrine (racemic) is also more potent than octopamine (racemic) at inducing light-emission in the firefly (Photinus species ...
Altitude sickness Choking game Hypothermia cap Space exposure Ulegyria Malhotra R, et al. (Nov 2001). "Hypoxia induces ... Prolonged hypoxia induces neuronal cell death via apoptosis, resulting in a hypoxic brain injury. Cases of total oxygen ... Hypothermia therapy for neonatal encephalopathy is the only evidence-supported therapy, but antioxidant drugs, control of blood ... Recent research suggests this may be due to an autoimmune response caused by carbon monoxide-induced changes in the myelin ...
In the conscious mouse, fluparoxan was effective by the oral route in preventing clonidine-induced hypothermia and ... 9aR in vitro and a similar potency in vivo in reversing the hypothermia induced in mice by clonidine. Fluparoxan has rat and ... Fluparoxan, orally prevented agonist UK-14304 induced sedation and bradycardia in a dose-related fashion in the dog. Fluparoxan ...
... s are induced ovulators and can breed throughout the year. Females can have their first litter at two to three years of ... Deaths result from several reasons-stillbirths, birth defects, cannibalism, hypothermia, neglect of cubs by mothers, and ... Compared to other felids, cheetahs need specialised care because of their higher vulnerability to stress-induced diseases; this ...
... s are able to lower their body temperatures to induce an intentional state of hypothermia called torpor. They ...
Emilio's initial treatment included being kept in a medically induced coma and induced hypothermia to minimize brain swelling. ...
... have effects in all components of the tetrad and induce hypomotility, catalepsy, hypothermia, and analgesia in rodents. ... Hypothermia (reduced body temperature) is determined by using a rectal probe to measure the rectal temperature. Analgesia is ... Data have shown, that also CB2 receptors are involved in the tetrad effects induced by cannabinoids, and other, associated with ... It is widely used for screening drugs that induce cannabinoid receptor-mediated effects in rodents. The four behavioral ...
"Central 5-HT3 receptor-induced hypothermia in mice: interstrain differences and comparison with hypothermia mediated via 5-HT1A ...
Fang Q, Wang YQ, He F, Guo J, Guo J, Chen Q, Wang R (April 2008). "Inhibition of neuropeptide FF (NPFF)-induced hypothermia and ... attenuates opioid-evoked hypothermia in mice". Peptides. 29 (7): 1183-90. doi:10.1016/j.peptides.2008.02.016. PMID 18406009. ...
... a hormone that is considered goiter-inducing.[12][13] Levothyroxine is also used as interventional therapy in people with ... which is a severe form of hypothyroidism characterized by mental status changes and hypothermia.[11] As it is a medical ...
Hypothermia. *Immersion diuresis. *Instinctive drowning response. *Laryngospasm. *Salt water aspiration syndrome. *Swimming- ...
Induced coma. *Mechanical ventilation. *Therapeutic hypothermia. *Total parenteral nutrition. *Tracheal intubation. Drugs. * ...
Hypothermia cap. *Space exposure. *Ulegyria. ReferencesEdit. *^ Malhotra R, et al. (Nov 2001). "Hypoxia induces apoptosis via ... Prolonged hypoxia induces neuronal cell death via apoptosis, resulting in a hypoxic brain injury.[1][2] ... Hypothermia therapy for neonatal encephalopathy is the only evidence-supported therapy, but antioxidant drugs, control of blood ... Recent research suggests this may be due to an autoimmune response caused by carbon monoxide-induced changes in the myelin ...
The official cause of death of both men was hypothermia, but toxicology reports later confirmed that both Troy Johnson, 29, and ... It has also been repeatedly noted for inducing irresistible cravings to re-administer. Reported modalities of intake include ... Physicians often treat MDPV overdose cases with anxiolytics, such as benzodiazepines, to lessen the drug-induced activity in ...
There may be a link between infant swimming and rhinovirus-induced wheezing illnesses. Others have indicated concerns that the ... hypothermia, hyponatremia, infectious illness, and lung damage from pool chemicals). The American Centers for Disease Control ... or that the infant could experience hypothermia, suffer from water intoxication after swallowing water, or develop ... "Association between infant swimming and rhinovirus-induced wheezing". Acta paediatrica (Oslo, Norway : 1992). 103: 1153-1158. ...
Hypothermia. *Immersion diuresis. *Instinctive drowning response. *Laryngospasm. *Salt water aspiration syndrome. *Swimming- ...
Infantile acrodynia induced by chronic low-dose mercury exposure, leading to elevated catecholamine accumulation and resulting ... Episodic with hypothermia (Hines and Bannick syndrome). *Episodic without hypothermia. *Olfactory. *Associated with systemic ... Use of selective serotonin reuptake inhibitors (e.g., sertraline) is a common cause of medication-induced secondary ...
... and by limiting the thrombin-induced inflammatory responses within the microvascular endothelium.Template:Nurse's Drug Handbook ...
Radiation-induced erythema multiforme. Radiation-induced hypertrophic scar. Radiation-induced keloid. Radiation-induced morphea ... Hypothermia. Immersion foot syndromes Trench foot. Tropical immersion foot. Warm water immersion foot. Chilblains. Frostbite. ... ACE inhibitors can induce angioedema.[13][14][15] ACE inhibitors block the enzyme ACE so it can no longer degrade bradykinin; ... amounts and is believed to be the predominant mediator leading to increased vascular permeability and vasodilation that induces ...
Hypothermia. *Immersion diuresis. *Instinctive drowning response. *Laryngospasm. *Salt water aspiration syndrome. *Swimming- ...
Neurotoxicity is another cause of brain damage that typically refers to selective, chemically induced neuron/brain damage.. .mw ... found a net 65% favorable outcomes rate in pediatric patients), barbiturate coma, hypertonic saline and hypothermia. Although ...
誘導昏迷(英语:Induced coma). *機械呼吸(英语:Mechanical ventilation) ... 低溫治療(英语:Therapeutic hypothermia). *靜脈營
van Nieuwenhuijzen, P.S.; McGregor, I.S.; Hunt, G.E. (2009). "The distribution of γ-hydroxybutyrate-induced Fos expression in ... hypothermia, bradycardia, hypertension, hyporeflexia, coma, and death.[15] ...
Drug Induced Hair Loss', American Hair Loss Association: "American Hair Loss Association - Drug Induced Hair Loss". Archived ... Hypothermia caps may be useful to prevent hair loss during some kinds of chemotherapy, specifically when tazanes or ... "Drug-Induced Hair Loss". Archived from the original on 2013-08-24.. Cite uses deprecated parameter ,deadurl=. (help). ... "Drug-Induced Hair Loss". Archived from the original on 2013-07-26.. Cite uses deprecated parameter ,deadurl=. (help). ...
A symptom (from Greek σύμπτωμα, "accident, misfortune, that which befalls",[1] from συμπίπτω, "I befall", from συν- "together, with" and πίπτω, "I fall") is a departure from normal function or feeling which is apparent to a patient, reflecting the presence of an unusual state, or of a disease. A symptom can be subjective or objective. Tiredness is a subjective symptom whereas cough or fever are objective symptoms.[2] In contrast to a symptom, a sign is a clue to a disease elicited by an examiner or a doctor.[3] For example, paresthesia is a symptom (only the person experiencing it can directly observe their own tingling feeling), whereas erythema is a sign (anyone can confirm that the skin is redder than usual). Symptoms and signs are often nonspecific, but often combinations of them are at least suggestive of certain diagnoses, helping to narrow down what may be wrong. In other cases they are specific even to the point of being pathognomonic. The term is sometimes also ...
低溫治療(英语:Therapeutic hypothermia). *靜脈營養(英语:Parenteral nutrition) ... 誘導昏迷(英语:Induced coma). *呼吸器(英语:Mechanical
Radiation-induced erythema multiforme. Radiation-induced hypertrophic scar. Radiation-induced keloid. Radiation-induced morphea ... Hypothermia. Immersion foot syndromes Trench foot. Tropical immersion foot. Warm water immersion foot. Chilblains. Frostbite. ... "Exercise-induced bronchospasm and atopy in Ghana: two surveys ten years apart". PLoS Med. 4 (2): e70. doi:10.1371/journal.pmed ...
Radiation-induced erythema multiforme. Radiation-induced hypertrophic scar. Radiation-induced keloid. Radiation-induced morphea ... Hypothermia. Immersion foot syndromes Trench foot. Tropical immersion foot. Warm water immersion foot. Chilblains. Frostbite. ... G-LOC cerebral hypoxia induced by excessive g-forces. *Histotoxic hypoxia, the inability of cells to take up or utilize oxygen ... Expression of Beta-Oxidation Related Genes Under Hypoxic Condition Induced Preeclamptic Model in Vitro and in Vivo". Endocrine ...
In 1897, Edmond Nocard showed that tetanus antitoxin induced passive immunity in humans, and could be used for prophylaxis and ... The autonomic effects of tetanus can be difficult to manage (alternating hyper- and hypotension hyperpyrexia/hypothermia) and ... Tetanus toxoid vaccine was developed by P. Descombey in 1924, and was widely used to prevent tetanus induced by battle wounds ...
... by pain-induced sympathetic stimulation, hypothermia, hypoxia, or hypervolemia from excessive intraoperative fluid therapy; and ... It seems that inhibition of nitric oxide synthesis may also play a role in cortisol induced hypertension.[21] ... It may occur before surgery during the induction of anesthesia; intraoperatively e.g. by pain-induced sympathetic nervous ... Cortisol induced hypertension cannot be completely explained by the activity of Cortisol on Aldosterone receptors. Experiments ...
It was discovered in 1965 that a strain of C3H/HeJ mice were immune to the endotoxin-induced shock.[110] The genetic locus for ... Abraham E, Singer M (October 2007). "Mechanisms of sepsis-induced organ dysfunction". Critical Care Medicine. 35 (10): 2408-16 ... This forced receptor interaction induces the production of pro-inflammatory chemical signals (cytokines) by T-cells.[40] ... Severe sepsis is defined as sepsis with sepsis-induced organ dysfunction or tissue hypoperfusion (manifesting as hypotension, ...
Hypothermia. *Investigation of diving accidents. *List of diving hazards and precautions. *List of legislation regulating ... Swimming-induced pulmonary edema. *List of signs and symptoms of diving disorders ...
Self-induced hypocapnia through hyperventilation is the basis for the dangerous schoolyard fainting game.[citation needed] ... Hypocapnia is sometimes induced in the treatment of medical emergencies such as intracranial hypertension[1] and hyperkalaemia ... Hypothermia. *Immersion diuresis. *Instinctive drowning response. *Laryngospasm. *Salt water aspiration syndrome. *Swimming- ...
Both animal[109] and human[110][111][112] studies have shown melatonin to protect against radiation-induced cellular damage. ... it can cause reduced blood flow and hypothermia.[29][needs update] In autoimmune disorders, evidence is conflicting whether ... Reiter RJ, Herman TS, Meltz ML (February 1998). "Melatonin reduces gamma radiation-induced primary DNA damage in human blood ... US patent 5449683, Wurtman RJ, "Methods of inducing sleep using melatonin", issued 12 September 1995, assigned to Massachusetts ...
Radiation-induced erythema multiforme. Radiation-induced hypertrophic scar. Radiation-induced keloid. Radiation-induced morphea ... Hypothermia. Immersion foot syndromes Trench foot. Tropical immersion foot. Warm water immersion foot. Chilblains. Frostbite. ... Self-induced hypocapnia by hyperventilation, as in shallow water or deep water blackout and the choking game ... There are many circumstances that can induce asphyxia, all of which are characterized by an inability of an individual to ...
... whether induced medically or caused by injury and/or illness, even if it is very deep, as long as some brain and bodily ... hypothermia, hypoglycemia, coma, and chronic vegetative states. Some comatose patients can recover to pre-coma or near pre-coma ...
Hypothermia. *Immersion diuresis. *Instinctive drowning response. *Laryngospasm. *Salt water aspiration syndrome. *Swimming- ...
Intolerance to cold and frequent complaints of being cold; body temperature may lower (hypothermia) in an effort to conserve ... Hypokalemia most commonly results in anorexic patients when restricting is accompanied by purging (induced vomiting or laxative ... or water pills to flush food out of their system after eating or may engage in self-induced vomiting though this is a more ... Anorexia often begins following a major life-change or stress-inducing event.[3] The diagnosis requires a significantly low ...
Induced Therapeutic Hypothermia, Therapeutic Hypothermia, Targeted Temperature Management. ... Induced Hypothermia, induced hypothermia, IND HYPOTHERMIA, HYPOTHERMIA IND, hypothermia induction, hypothermia induction ( ... Hypothermia therapy, (Hypothermia) or (induction of), Induced hypothermia, Hypothermia, Therapeutic, Therapeutic Hypothermia, ... Induced Therapeutic Hypothermia. Aka: Induced Therapeutic Hypothermia, Therapeutic Hypothermia, Targeted Temperature Management ...
The cooling capacity of the system is sufficient to induce therapeutic levels of hypothermia in approximately 30 to 90 minutes ... Disclosed is a system and method for inducing therapeutic levels of hypothermia in a patient in the emergent care setting. The ... of inducing hypothermia in a patient at risk of secondary ischemic injury where protective levels of hypothermia is induced in ... 7. A method for inducing hypothermia in a patient, comprising: covering at least a portion of a patients head with a cap to ...
Hypothermia as much as 10 C. at an ambient temperature of 20 C. is possible, with complete recovery and few, if any, side ... agonist and a dopamine receptor blocker or dopamine receptor agonist provides a synergistic effect in inducing hypothermia and/ ... A method for inducing hypothermia or poikilothermia which comprises administering to a human or animal to produce hypothermia ... Particularly, hypothermia and/or poikilothermia can be induced in mammals by administering thereto an effective amount of kappa ...
Procedure: Mild induced hypothermia (32-34°C) Mild Induced hypothermia:. Investigators are advised to use the cooling ... Experimental: Hypothermia mild induced hypothermia (32-34°C) during 48 hours followed by passive rewarming ... IHPOTOTAM : Induced HyPOthermia TO Treat Adult Meningitis (IHPOTOTAM). The safety and scientific validity of this study is the ... Mild Induced hypothermia:. Investigators are advised to use the cooling techniques as used in patients with cardiac arrest. ...
Procedure: Mild induced hypothermia (32-34°C) Mild Induced hypothermia:. Investigators are advised to use the cooling ... Experimental: Hypothermia mild induced hypothermia (32-34°C) during 48 hours followed by passive rewarming ... Hypothermia will be induced by cold saline infusion as described in appendix 5 [6, 48]. Core temperature will be monitored by ... Mild Induced hypothermia:. Investigators are advised to use the cooling techniques as used in patients with cardiac arrest. ...
... hypothermia induced include In vitro Assessment of Myocardial Protection following Hypothermia-Preconditioning in a Human ... Bilateral Common Carotid Artery Occlusion as an Adequate Preconditioning Stimulus to Induce Early Ischemic Tolerance to Focal ... A Murine Model of Ischemic Retinal Injury Induced by Transient Bilateral Common Carotid Artery Occlusion, Transplantation of ... In vitro Assessment of Myocardial Protection following Hypothermia-Preconditioning in a Human Cardiac Myocytes Model. Authors ...
Mohak Davé, emergency physician at Northeast Georgia Medical Center, explains how induced hypothermia can help patients recover ... ER doctors induced hypothermia, and the treatment was continued in the intensive-care unit, for about 36 hours. All told, ... Its called induced hypothermia, or deliberately lowering the patients body temperature. Its easy, cheap, and low-tech, and ... Induced hypothermia is now used for some patients undergoing cardiac bypass surgery. But Northeast Georgia Medical Center only ...
Reversible thrombocytopenia was also induced by forced hypothermia in both hibernating (hamster) and non-hibernating (rat and ... Pharmacological torpor induced by injection of 5′-AMP in mice did not induce thrombocytopenia, possibly because 5′-AMP inhibits ... pharmacologically induced torpor and forced hypothermia. Splenectomies were performed to unravel potential storage sites of ... Interestingly, hamster platelets during torpor do not express P-selectin, but expression is induced by treatment with ADP. ...
In humans, mild or moderate hypothermia has been used to reduce tissue damages, particularly after cardiac or spinal cord ... Abnormally low BODY TEMPERATURE that is intentionally induced in warm-blooded animals by artificial means. ... Induced; Mild Hypothermia, Induced; Moderate Hypothermia, Induced; Induced Mild Hypothermia; Induced Mild Hypothermias; Induced ... Moderate Hypothermia; Induced Moderate Hypothermias; Mild Hypothermias, Induced; Moderate Hypothermias, Induced ...
... thereby inducing hypothermia, thus benefiting patients suffering from illnesses characterized by tissue anoxia. ... The present invention relates to the induction of hypothermia in humans in a predictable and dose responsive fashion by use of ... WO2009071097A1 - Use of hypothermia inducing drugs - Google Patents. Use of hypothermia inducing drugs Download PDF Info. ... Use of hypothermia inducing drugs to treat ischemia WO2008040361A2 (en) 2008-04-10. Use of a combination of hypothermia ...
CART induced a long-lasting (,6 h) hypothermia: a 1.5°C and 1.6°C drop in Tc for the 1.0 and 2.0 μg doses. Hindbrain CART ... Effect of GLP-1R blockade by exendin 9-39 (100 μg) on the CART-induced (1 μg) hypothermia with drugs delivered to the fourth v ... 2000) Characterization of D-fenfluramine-induced hypothermia: evidence for multiple sites of action. Eur J Pharmacol 390:275- ... We recently showed (Hayes et al., 2008) that stimulation of hindbrain GLP-1R induces hypothermia similar in duration and size ...
... participates in the multimodal molecular induction of hypothermia-induced ischemic tolerance. Mild (32°C) to moderate (28°C) ... Of note, hypothermic exposure did not provide an additional increase in protection from pMCAO-induced ischemic brain damage in ... Of note, hypothermic exposure did not provide an additional increase in protection from pMCAO-induced ischemic brain damage in ... from OGD and ROG-induced cell death. Hypothermic exposure either before or after permanent middle cerebral artery occlusion ( ...
Mild induced hypothermia (MIH) was introduced for post cardiac arrest care in Sweden in 2003, based on two clinical trials. ...
Induced hypothermia helps cardiac arrest patients. Todd Smith Tuesday. Dec 14, 2010 at 12:01 AM Dec 14, 2010 at 1:00 PM ... The patients core body temperature drops down to between 91 and 92 degrees, which induces a therapeutic hypothermia. Patients ... The therapeutic hypothermia treatment at Memorial uses a Gaymar machine similar to the one at St. Johns. It circulates cool ... Kevin Hall is doing better after the hypothermia treatment, followed by stent procedures for his heart and a toe amputation at ...
Alterations in Hippocampal Field Potentials in the Denate Gyrus are Largely Associated with Anesthesia-Induced Hypothermia. ... but rather secondary to the effects of hypothermia induced by the anesthesia necessary for the experimental protocols. Despite ... Alterations in Hippocampal Field Potentials in the Denate Gyrus are Largely Associated with Anesthesia-Induced Hypothermia. ... Alterations in Hippocampal Field Potentials in the Denate Gyrus are Largely Associated with Anesthesia-Induced Hypothermia ...
... a team of researchers studied whether inducing hypothermia in the pancreata of rats could reduce the severity of AP induced by ... New vein of research focuses on inducing pancreatic hypothermia to reduce injury associated with mild and severe acute ... New vein of research focuses on inducing pancreatic hypothermia to reduce injury associated with mild and severe acute ... "We established that local pancreatic hypothermia can be induced transgastrically and used therapeutically to slow multiple ...
Conclusions: HOE642 used during resuscitation induced hypotension. Hypothermia may prevent the adverse hemodynamic effects ... HOE642 Used During Resuscitation Induced Obviously Adverse Hemodynamic Effects Which May Be Improved by Hypothermia. Jiaxu Dong ... HOE642 Used During Resuscitation Induced Obviously Adverse Hemodynamic Effects Which May Be Improved by Hypothermia ... HOE642 Used During Resuscitation Induced Obviously Adverse Hemodynamic Effects Which May Be Improved by Hypothermia ...
Induced" by people in this website by year, and whether "Hypothermia, Induced" was a major or minor topic of these publications ... "Hypothermia, Induced" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical ... The feasibility of inducing mild therapeutic hypothermia after cardiac resuscitation using iced saline infusion via an ... The effect of ambient temperature on cold saline during simulated infusion to induce therapeutic hypothermia. Resuscitation. ...
... which induce hypothermia. The aim of this study was to investigate... ... Hypothermia, Induced. Abnormally low BODY TEMPERATURE that is intentionally induced in warm-blooded animals by artificial means ... which induce hypothermia. The aim of this study was to investigate whether the receptor agonist ABS 201 could induce ... Anesthesia-Induced Hypothermia (AIH) has been reported to be the cause of many postoperative adverse effects, including ...
Effect of 5-lipoxygenase inhibitor against lipopolysaccharide-induced hypothermia in mice. Authors: Singh, Vijay Pal. Patil, ... These results suggest a possible involvement of leukotrienes in LPS-induced hypothermia and the potential protective role of 5- ... Hypothermia;Lipopolysaccahride;Lcukotriene B4;5-Lipoxygcnase;5-LOX;Prostaglandin E2. ... Bacterial endotoxin produces sepsis associated with alterations in body temperature (fever or hypothermia). The intraperitoneal ...
You searched for: Language English Remove constraint Language: English Subject Hypothermia, Induced Remove constraint Subject: ... 1. Hypothermia for General and Cardiac Surgery: With Techniques of Some Open Intracardiac Procedures Under Hypothermia ... 3. The Current Status of Hypothermia in Cardiovascular Surgery Creator:. Swan, Henry (Henry Swan) and Paton, Bruce C. (Bruce C ... 7. Surgery by Direct Vision in the Open Heart during Hypothermia Creator:. Swan, Henry (Henry Swan), Zeavin, Irvin (Irvin ...
Conclusions: Mild induced hypothermia does not seem to influence 30-day mortality after out-of-hospital cardiac arrest due to ... Abstract 117: Mild Induced Hypothermia and Emergency Percutaneous Coronary Intervention After Out-of-Hospital Cardiac Arrest ... Abstract 117: Mild Induced Hypothermia and Emergency Percutaneous Coronary Intervention After Out-of-Hospital Cardiac Arrest ... Abstract 117: Mild Induced Hypothermia and Emergency Percutaneous Coronary Intervention After Out-of-Hospital Cardiac Arrest ...
Conclusions: Intra-resuscitated induced therapeutic hypothermia confers no benefit in the rate of return of spontaneous ... Abstract 20895: Intra-Resuscitated versus Pre-Hospital Induced Therapeutic Hypothermia With Cold Saline. ... and 6-month survival in patients with cardiac arrest as compared to pre-hospital induced therapeutic hypothermia. ... Therapeutic hypothermia (TH) has been shown to improve neurological function and survival when applied in post-cardiac arrest ...
Hypothermia-induced J-orso-called Osborn waves can be detected under therapeutic hypothermia in approximately 20-40% of cases. ... Hypothermia-induced ECG changes: characteristic, but not specific. Med. Klin.-Intensivmed Notfallmed., 113 (3). S. 217 - 221. ... but not pathognomonic for hypothermia. An electrocardiographic diagnosis under hypothermia after cardiac arrest should always ... be done with caution due to the various hypothermia-associated electromechanical changes of the myocardium. ...
... hypothermia Language English Remove constraint Language: English Subject Hypothermia, Induced Remove constraint Subject: ... 1. Hypothermia for General and Cardiac Surgery: With Techniques of Some Open Intracardiac Procedures Under Hypothermia ... You searched for: Exhibit Tags hypothermia Remove constraint Exhibit Tags: ...
Induced hypothermia is the only therapy with proven efficacy to reduce brain damage after perinatal asphyxia. While hypothermia ... Induced hypothermia is the only therapy with proven efficacy to reduce brain damage after perinatal asphyxia. While hypothermia ... neuronal RBM3 up-regulation in response to hypothermia apparently accounts for a substantial proportion of hypothermia-induced ... neuronal RBM3 up-regulation in response to hypothermia apparently accounts for a substantial proportion of hypothermia-induced ...
... a Prominent Eustachian Valve and Induced Hypothermia Lead to Severe Pulmonary Embolism in a Resuscitated Patient after STEMI? ... Did the Coexistence of a Pacemaker Probe, a Prominent Eustachian Valve and Induced Hypothermia Lead to Severe Pulmonary ... a Prominent Eustachian Valve and Induced Hypothermia Lead to Severe Pulmonary Embolism in a Resuscitated Patient after STEMI? ...
A Mechanism Useful for Prevention of Anaesthesia-Induced Hypothermia. EVA Selldén, Tomas Brundin, John Wahren ... A Mechanism Useful for Prevention of Anaesthesia-Induced Hypothermia ... A Mechanism Useful for Prevention of Anaesthesia-Induced Hypothermia ... A Mechanism Useful for Prevention of Anaesthesia-Induced Hypothermia ...
Central - adrenergic mechanism of catecholamine induced hypothermia in guinea pigs. RA Khan1, KP Gupta2 1 2 ... Khan R A, Gupta K P. Central - adrenergic mechanism of catecholamine induced hypothermia in guinea pigs.Indian J Pharmacol 1981 ... Khan R A, Gupta K P. Central - adrenergic mechanism of catecholamine induced hypothermia in guinea pigs. Indian J Pharmacol [ ... An involvement of central a-adrenoceptors in the production of catecholamine hypothermia in guinea-pig is suggested. The after- ...
Title: The effect of cerebral hypothermia on white and grey matter injury induced by severe hypoxia in preterm fetal sheep  ... The effect of cerebral hypothermia on white and grey matter injury induced by severe hypoxia in preterm fetal sheep. Bennet, ... The effect of cerebral hypothermia on white and grey matter injury induced by severe hypoxia in preterm fetal sheep. ... Title: Therapeutic hypothermia and its effects on the preterm fetal sheep  Author: Barrett, Robert Date: (2011) ...
  • Moderate hypothermia (body temperature is downed between 32 and 34°C°) made the proof of its efficiency in certain cerebral pathologies (notably the cerebral distress after cardiac arrest or oxygen lack in neonates) but was never evaluated in meningitis. (clinicaltrials.gov)
  • Dr. Mohak Davé, emergency physician at Northeast Georgia Medical Center, explains how induced hypothermia can help patients recover from cardiac arrest. (gainesvilletimes.com)
  • Davé said hypothermia is not needed for every patient who has suffered a cardiac arrest. (gainesvilletimes.com)
  • In a rat model of cardiac arrest, better postresuscitation myocardial function, neurological deficit scores, and longer duration of survival were observed by the pharmacologically induced hypothermia with WIN55, 212-2. (curehunter.com)
  • In humans, two trials conducted in cardiac arrest patients have shown improved neurological outcome of inducing hypothermia [12;13]. (google.com)
  • The therapeutic hypothermia did not increase the complication rate in these two trials and the use of induced hypothermia in co- matose survivors of cardiac arrest is now recommended internationally [14]. (google.com)
  • Mild induced hypothermia (MIH) was introduced for post cardiac arrest care in Sweden in 2003, based on two clinical trials. (ovid.com)
  • The procedure used at Memorial is called therapeutic hypothermia, a procedure that helps stop brain damage in patients who suffer cardiac arrest. (lincolncourier.com)
  • Cardiac arrest was induced by 8 min asphyxia. (ahajournals.org)
  • The aim of this study was to investigate whether the receptor agonist ABS 201 could induce therapeutic hypothermia and improve postresuscitation outcomes in a ventricular fibrillation cardiac arrest (VFCA) rat model. (bioportfolio.com)
  • Therapeutic hypothermia has been integrated into international resuscitation guidelines to improve survival after out-of-hospital cardiac arrest (OHCA). (ahajournals.org)
  • Mild induced hypothermia does not seem to influence 30-day mortality after out-of-hospital cardiac arrest due to STEMI. (ahajournals.org)
  • Therapeutic hypothermia (TH) has been shown to improve neurological function and survival when applied in post-cardiac arrest care. (ovid.com)
  • Hypothesis: This retrospective control study was to compare the rate of return of spontaneous circulation, hospital survival, neurological status, and 6-month survival in patients with cardiac arrest who were treated with intra-resuscitation versus pre-hospital induced therapeutic hypothermia. (ovid.com)
  • Conclusions: Intra-resuscitated induced therapeutic hypothermia confers no benefit in the rate of return of spontaneous circulation, hospital survival, neurological status, and 6-month survival in patients with cardiac arrest as compared to pre-hospital induced therapeutic hypothermia. (ovid.com)
  • An electrocardiographic diagnosis under hypothermia after cardiac arrest should always be done with caution due to the various hypothermia-associated electromechanical changes of the myocardium. (uni-koeln.de)
  • We evaluated the efficacy of and tolerance to mild therapeutic hypothermia achieved using an endovascular cooling system, and its ability to reach and maintain a target temperature of 33°C after cardiac arrest. (biomedcentral.com)
  • Forty patients admitted to the intensive care unit following out-of-hospital cardiac arrest underwent mild induced hypothermia (MIH). (biomedcentral.com)
  • Recently, induced hypothermia is being explored, with initially encouraging results, in other, less planned situations, such as pre-hospital treatment of post- cardiac arrest patients, as well as myocardial infarction without arrest, and in stroke . (citizendium.org)
  • Therefore, we studied the effect of induced hypothermia on immune response after cardiac arrest. (biomedcentral.com)
  • Patients with a body temperature of 33°C did not differ from patients with a body temperature of 36°C, suggesting induced hypothermia does not affect immune response in patients with cardiac arrest. (biomedcentral.com)
  • Induced hypothermia for patients with cardiac arrest. (freethesaurus.com)
  • Mild therapeutic hypothermia is indicated in patients surviving out-of-hospital cardiac arrest due to ventricular fibrillation. (bioportfolio.com)
  • Ischemia-reperfusion (I/R)-induced oxidative stress is one of the main mechanisms of tissue injury after cardiac arrest (CA). A decrease in antioxidant defenses may contribute to I/R injury. (bioportfolio.com)
  • Therapeutic Hypothermia in Cardiac Arrest. (bioportfolio.com)
  • The aim of this study was to develop a scoring system for identifying the post-cardiac arrest syndrome (PCAS) patients with a good potential for recovery prior to the initiation of induced therapeutic hypothermia. (biomedcentral.com)
  • Data of a total of 151 consecutive adults who underwent induced hypothermia after cardiac arrest (77 learning cases from two hospitals and 74 validation cases from two other hospitals) were analyzed. (biomedcentral.com)
  • Finally, using all the data, we established a post-Cardiac Arrest Syndrome for induced Therapeutic hypothermia (CAST) score to predict the neurologic prognosis prior to initiation of induced hypothermia. (biomedcentral.com)
  • We conducted a multi-center, retrospective, observational study examining adult patients who were treated with induced hypothermia after experiencing cardiac arrest. (biomedcentral.com)
  • Therapeutic hypothermia (TH) is considered to improve survival with favorable neurological outcome in the case of global cerebral ischemia after cardiac arrest and perinatal asphyxia. (frontiersin.org)
  • In week three of the Massive Open Online Course from Coursera on the topic of Cardiac Arrest, Hypothermia, and Resuscitation Dr. Abella discussed the reason for and action of therapeutic hypothermia for patients with return of spontaneous circulation (ROSC). (everydayemstips.com)
  • I don't work in EMS systems that use induced hypothermia for patients that have Return of Spontaneous Circulation" after cardiac arrest - yet. (everydayemstips.com)
  • In patients who are in a coma after resuscitation from cardiac arrest with nonshockable rhythm, does moderate therapeutic hypothermia improve neurologic outcomes compared with targeted normothermia? (annals.org)
  • Randomized controlled trial (Therapeutic Hypothermia after Cardiac Arrest in Nonshockable Rhythm [HYPERION] trial). (annals.org)
  • Therapeutic hypothermia is an effective cytoprotectant and promising intervention shown to improve outcome in patients following cardiac arrest and neonatal hypoxia-ischemia. (springeropen.com)
  • An analysis of multiple studies has shown hypothermia therapy (HT) provides critical benefits for people who suffer cardiac arrest, though it remains under-utilized by hospitals and emergency medical service crews, according to researchers. (foxnews.com)
  • Accordingly, urgent coronary angiography /PCI and mild induced hypothermia should be incorporated in comprehensive postresuscitation intensive care protocol for the management of comatose survivors of cardiac arrest. (signavitae.com)
  • 11) This is in accordance also with our observations in consecutive comatose survivors of out-of-hospital cardiac arrest in whom survival with good neurological recovery improved from 15% between 1995-1997 to 40% between 2006-2008 when treatment with urgent PCI and hypothermia exceeded 70 and 90%, respectively (figure 1). (signavitae.com)
  • Therapeutic hypothermia is worldwide used to avoid neurological damage after cardiac arrest. (clinmedjournals.org)
  • A number of recent studies have concluded that the use of induced hypothermia can improve survival and limit the level of neurological impairment following cardiac arrest. (ispub.com)
  • To audit survival and neurological recovery outcomes in patients treated with induced hypothermia within the Intensive Care Unit (ICU) following cardiac arrest. (ispub.com)
  • Several studies have shown that the use of induced hypothermia can improve rates of survival and level of neurological function following a cardiac arrest 5, 6, 7 . (ispub.com)
  • This audit was conducted to review the cases of cardiac arrest presenting to, or occurring in, St Peter's Hospital in 2009-10 in order to assess the neurological outcomes of patients who were cooled on the ICU, and to determine whether therapeutic hypothermia should be implemented as standard care following cardiac arrest, or, if not, in which cases it would be most beneficial. (ispub.com)
  • They demonstrated that treatment with moderate hypothermia improved outcomes in patients with coma after resuscitation from an out-of-hospital cardiac arrest. (ispub.com)
  • A multicentre study by the Hypothermia After Cardiac Arrest Study Group demonstrated a 55% favourable outcome in the hypothermia group (32°C to 34°C, as measured in the bladder, for 24 hours) compared with 39% of those treated with normothermia following cardiac arrest 7 . (ispub.com)
  • In 2003, the American Heart Association endorsed the use of therapeutic hypothermia following cardiac arrest . (hubpages.com)
  • Hypothermia used in cardiac arrest - in patients who were resuscitated within 5-15 minutes after collapse and hypothermia begun within 2 hours or less - patients cooled over a 24-hour period and to 32-34 degrees Centigrade or 90-93 degrees Fahrenheit - half of the patients experienced favorable outcomes and the standard group had a 39% recovery rate. (hubpages.com)
  • Therapeutic hypothermia is a deliberate reduction of the body temperature that may be administered to patients who do not regain consciousness even after circulation is resumed following a cardiac arrest. (medindia.net)
  • Therapeutic hypothermia involves the lowering of body temperature to slow down metabolic process, especially those that affect the brain triggered by a cardiac arrest that occurs outside the safety of a hospital. (medindia.net)
  • In the 1980s, the use of hypothermia on dogs after cardiac arrest demonstrated positive outcomes including neurological status and survival. (wikipedia.org)
  • In 2005, the American Heart Association implemented recommendations and guidelines for mild hypothermia in post-resuscitation support after cardiac arrest with return of spontaneous circulation. (wikipedia.org)
  • A study conducted in 2002-2004 showed that treatment with therapeutic hypothermia for patients resuscitated after cardiac arrest due to ventricular fibrillation led to a positive outcome (Glasgow-Pittsburgh Cerebral Performance category 1 or 2) in 24 of 43 patients compared to only 11 of 43 patients in the standard resuscitation group where no hypothermia was used in treatment. (wikipedia.org)
  • Non-invasively induced therapeutic hypothermia has been shown to reduce mortality of successfully resuscitated cardiac arrest victims by 35 percent and increase the chance of a good neurologic outcome by 39 percent. (wikipedia.org)
  • It is a non-invasive precision temperature management system that is used to induce hypothermia in comatose patients that have suffered from Sudden Cardiac Arrest (SCA) and patients at risk for ischemic brain damage. (wikipedia.org)
  • After 48 hours, the technique of hypothermia will be suspended and body temperature will return passively and gradually to normal. (clinicaltrials.gov)
  • It's called induced hypothermia, or deliberately lowering the patient's body temperature. (gainesvilletimes.com)
  • Abnormally low BODY TEMPERATURE that is intentionally induced in warm-blooded animals by artificial means. (curehunter.com)
  • Newman, now 34, was resuscitated on the way to the center, rushed into the intensive care unit and had her body temperature cooled with a form of hypothermia to slow down her brain's demand for oxygen. (lincolncourier.com)
  • The patient's core body temperature drops down to between 91 and 92 degrees, which induces a therapeutic hypothermia. (lincolncourier.com)
  • Bacterial endotoxin produces sepsis associated with alterations in body temperature (fever or hypothermia). (niscair.res.in)
  • In its most basic definition, hypothermia is a mammalian body temperature significantly below normal for the species. (citizendium.org)
  • There are consistent animal and human data that mild to moderate hypothermia (reducing body temperature to 32-34oC) is generally safe and improves outcome after brain ischemia even when initiated hours after ischemia occurs. (grantome.com)
  • Heldmaier G, Ruf T (1992) Body temperature and metabolic rate during natural hypothermia in endotherms. (springer.com)
  • CONCLUSION: The data is consistent with a hypothermia related alteration in neuronal signalling following anaesthesia, and emphasises the importance of maintaining the body temperature of rodents when monitoring insulin (or growth factor/neurotrophic agent) action in the brain of anesthetised rodents. (ulster.ac.uk)
  • The strains differed at most times and doses in their acute reductions in body temperature with respect to their predrug base lines, which indicated genetic control of sensitivity to ethanol-induced hypothermia. (elsevier.com)
  • Hypothermia is defined as a body temperature (core, or internal body temperature) of less than about 95 F (35 C). Usually, hypothermia occurs when the body's temperature regulation is overwhelmed by a cold environment. (medicinenet.com)
  • Accidental hypothermia usually occurs from an exposure to cold that results in lowering the body temperature. (medicinenet.com)
  • Intentional hypothermia is body temperature lowering induced usually for a medical procedure. (medicinenet.com)
  • Body temperature, when discussing hypothermia, is usually termed 'core' temperature. (medicinenet.com)
  • The cause of hypothermia is the inability of the body's temperature regulation system to keep the body's core temperature between 35.6 C and 37.5 C (96.08 F and 99.5 F), so any body temperature below about 35.6 C (96.08 F) is considered hypothermic by many doctors. (medicinenet.com)
  • Bernard et al 6 studied 77 patients with out of hospital cardiac arrests who were each randomly assigned to care with normothermia or hypothermia (core body temperature reduced to 33°C within 2 hours of the return of spontaneous circulation and maintained at that temperature for 12 hours). (ispub.com)
  • A person with mild hypothermia will have a body temperature of 90°F to 95°F or 32°C to 35°C. (wikihow.com)
  • A person with severe hypothermia will have a body temperature below 82°F or 28°C. (wikihow.com)
  • However, the early research focused on deep hypothermia (defined as body temperature 20-25 degrees Centigrade which is 68-77 degrees Fahrenheit). (hubpages.com)
  • However, there seems to be evidence that hypothermia lowers the body temperature to reduce intracranial pressure and can thus prevent further brain damage by allowing the tissues to heal. (hubpages.com)
  • Hypothermia , defined as an unintentional decline in the core body temperature to below 35degrees C, is a life -threatening condition. (bvsalud.org)
  • Hypothermia occurs when body heat is lost faster than it can be replaced and the normal body temperature (98.6°F) drops to less than 95°F. Hypothermia is most likely at very cold temperatures, but it can occur even at cool temperatures (above 40°F), if a person becomes chilled from rain, sweat, or submersion in cold water. (isri.org)
  • Hypothermia is a condition where the body temperature is lowered to below 35 0 C. This can be a gradual process or could be due to a sudden decrease like an accident that leaves an individual stranded in heavy snow. (medindia.net)
  • The risk of a loss of body temperature and hypothermia increase with the duration of surgery, especially for surgery that lasts more than one hour. (wikipedia.org)
  • Therapeutic hypothermia, which lowers the patient's body temperature to levels between 32-34 °C (90-93 °F), is used to help reduce the risk of the ischemic injury to the brain following a period of insufficient blood flow. (wikipedia.org)
  • In meningitis animal studies and in severe traumatic brain injury, moderate hypothermia is able to diminish cerebral oedema and brain inflammation. (clinicaltrials.gov)
  • Thus, the objective of this study is to compare two strategies: only usual care or usual care completed by moderate hypothermia. (clinicaltrials.gov)
  • The investigators believe that moderate hypothermia will improve the prognosis of the most severe patients. (clinicaltrials.gov)
  • In humans, mild or moderate hypothermia has been used to reduce tissue damages, particularly after cardiac or spinal cord injuries and during subsequent surgeries. (curehunter.com)
  • Although efficacy of hypothermia in improving functional outcome of mild to moderate traumatic SCI has been demonstrated, hypothermia may not be protective against severe traumatic SCI. (curehunter.com)
  • Mild (32°C) to moderate (28°C) hypothermic treatment(s) during OGD (oxygen-glucose-deprivation) or ROG (restoration of oxygen/glucose) increased global SUMO-conjugation levels and protected cells (both SHSY5Y and E18 rat cortical neurons) from OGD and ROG-induced cell death. (frontiersin.org)
  • It is also important to treat infants with moderate to severe HIE with induced hypothermia to reduce neurological disability and mortality. (freethesaurus.com)
  • Lack of effect of moderate hypothermia on brain tissue oxygenation after acute intracranial hypertension in pigs. (biomedsearch.com)
  • In this study, we explored the effect of moderate hypothermia on brain tissue oxygenation following acute intracranial hypertension in micropigs. (biomedsearch.com)
  • Twenty healthy juvenile micropigs weighting 4-6 kg were randomized into two groups: a normothermia group (n = 10) and a moderate hypothermia group (n = 10). (biomedsearch.com)
  • In sum, moderate hypothermia significantly decreased ICP, reduced P(br)CO(2), and increased pH(br) values, but did not improve cerebral oxygenation following acute intracranial hypertension. (biomedsearch.com)
  • Therapeutic hypothermia is beneficial in children with moderate EAI. (bioportfolio.com)
  • Animals were subjected to hypoxia alone, IAI and hypoxia, IAI and hypoxia before induction of moderate hypothermia (33 degrees C), IAI and hypoxia induced during hypothermic intervention, and IAI and hypoxia initiated after hypothermia. (biomedsearch.com)
  • BACKGROUND: We hypothesized that the arch-first procedure without extra devices under moderate-to-mild systemic hypothermia during acute type A aortic dissection is safe and efficient and will improve patient outcome compared with the standard total arch replacement technique. (minervamedica.it)
  • CONCLUSIONS: In patients with acute type A aortic dissection involving the arch, the innovative arch-first surgical procedure could provide feasible and safe treatment outcomes, which brings us closer to the goal of performing surgery with moderate-to-mild systemic hypothermia with better cerebral, distal organ, and survival outcomes. (minervamedica.it)
  • Shen K, Zhou X, Tan L, Li F, Xiao J, Tang H. An innovative arch-first surgical procedure under moderate hypothermia for acute type A aortic dissection. (minervamedica.it)
  • Note any symptoms of moderate hypothermia. (wikihow.com)
  • A person with moderate hypothermia will usually stop shivering completely and may have slurred speech or poor judgement. (wikihow.com)
  • 28-32 0 C) In moderate hypothermia, blood pressure and pulse of the patient is considerably lowered with no voluntary movements of the body. (medindia.net)
  • We sought to find the effects of HOE642 with or without hypothermia on resuscitation in rats. (ahajournals.org)
  • HOE642 used during resuscitation induced hypotension. (ahajournals.org)
  • Mader TJ, Walterscheid JK, Kellogg AR, Lodding CC. The feasibility of inducing mild therapeutic hypothermia after cardiac resuscitation using iced saline infusion via an intraosseous needle. (umassmed.edu)
  • The occurrence of J-waves in the context of the targeted temperature management after cardiopulmonary resuscitation is characteristic, but not pathognomonic for hypothermia. (uni-koeln.de)
  • Can cerebellar and brainstem apparent diffusion coefficient (ADC) values predict neuromotor outcome in term neonates with hypoxic-ischemic encephalopathy (HIE) treated with hypothermia? (umassmed.edu)
  • The consequences of therapeutic hypothermia for neonatal hypoxic-ischemic encephalopathy are poorly understood. (elsevier.com)
  • We report a 47-year-old Caucasian man with liver cirrhosis who developed posterior reversible encephalopathy syndrome following an upper gastrointestinal hemorrhage and who was managed with induced hypothermia for control of intracranial hypertension and continuous veno-venous hemodiafiltration for severe hyperammonemia. (biomedcentral.com)
  • We believe this is the first documented case report of posterior reversible encephalopathy syndrome associated with cirrhosis as well as the first report of the use of induced hypothermia and continuous veno-venous hemodiafiltration in this setting. (biomedcentral.com)
  • Goldstein, H. Induced Hypothermia for Hypoxic-Ischaemic Encephalopathy - Part 3, Don't Forget the Bubbles, 2015. (dontforgetthebubbles.com)
  • Should therapeutic hypothermia be offered to babies with mild neonatal encephalopathy in the first 6 h after birth? (belmontmedtech.com)
  • Data from large randomized clinical trials indicate that therapeutic hypothermia, using either selective head cooling or systemic cooling, is an effective therapy for neonatal encephalopathy. (aappublications.org)
  • In 2005, the National Institute of Child Health and Human Development (NICHD) convened a workshop to evaluate the status of knowledge regarding the safety and efficacy of hypothermia as a neuroprotective therapy for neonatal hypoxic-ischemic encephalopathy. (aappublications.org)
  • 4 After showing consistent benefit in animal models, the safety, feasibility, and practicality of using induced hypothermia in infants who have neonatal encephalopathy were investigated in several small studies. (aappublications.org)
  • Six large randomized clinical trials of induced hypothermia for neonatal encephalopathy were published from 2005 to 2011. (aappublications.org)
  • abstract = "Δ8-Tetrahydrocannabinol (THC)- and 8β, 9β-epoxyhexahydrocannabinol (EHHC)-tolerant mice were tolerant to the hypothermia produced by morphine while 8α,9α-EHHC-tolerant mice were not. (elsevier.com)
  • Despite such work and the reproducible demonstrations of hypothermic neuroprotection by a number of laboratories, the cellular and molecular mechanisms underlying brain cytoprotection induced via exposure to hypothermia are not fully understood. (frontiersin.org)
  • Inflammatory cytokines are involved in dihydrocapsaicin (DHC) and regional cooling infusion (RCI)-induced neuroprotection in ischemic rat. (bioportfolio.com)
  • Together, neuronal RBM3 up-regulation in response to hypothermia apparently accounts for a substantial proportion of hypothermia-induced neuroprotection. (uzh.ch)
  • Adverse effects from suboptimal rewarming could diminish neuroprotection from hypothermia. (elsevier.com)
  • The cold-inducible protein RBM3 mediates hypothermic neuroprotection against nitric oxide (NO)-induced cell death. (bioportfolio.com)
  • A pilot protocol and review of triple neuroprotection with targeted hypothermia, controlled induced hypertension, and. (amegroups.com)
  • Therapeutic hypothermia is promising in clinical settings for stroke neuroprotection. (hindawi.com)
  • More importantly, these findings led to the realization that hypothermia-induced neuroprotection is not only limited to decreased oxygen and glucose demands, but the mechanisms involved are indeed much more intricate. (springeropen.com)
  • 01). The fact that mild hypothermia (34.5°C) plus lamotrigine (20 mg/kg) together were more effective in inhibiting extracellular glutamate accumulation than hypothermia (34.5°C) or lamotrigine (20 mg/kg) alone, suggests the potential for increased neuroprotection by the addition of lamotrigine to mild hypothermia. (elsevier.com)
  • Supracollicular decerebration eliminated the hypothermic response observed in intact rats to hindbrain ventricular CART, suggesting that forebrain processing is required for hypothermia. (jneurosci.org)
  • Pretreatment with the GLP-1R antagonist (exendin-9-39) in control rats attenuated CART hypothermia and hypophagia, indicating that GLP-1R activation contributes to hypothermic and hypophagic effects of hindbrain CART, whereas CART-induced hyperglycemia was not altered by GLP-1R blockade. (jneurosci.org)
  • To address this challenge, a team of researchers studied whether inducing hypothermia in the pancreata of rats could reduce the severity of AP induced by different methods. (mayoclinic.org)
  • VF was electrically induced in 12 rats. (bioportfolio.com)
  • This study demonstrates reduced axonal swelling in the peri-injury zones of spinal cord injured rats treated with systemic hypothermia. (nih.gov)
  • Sabir H, Scull-Brown E, Liu X, Thoresen M. Immediate hypothermia is not neuroprotective after severe hypoxia-ischemia and is deleterious when delayed by 12 hours in neonatal rats. (belmontmedtech.com)
  • The effect of hypothermia on the ischemia‐induced changes in the subcellular distribution of protein kinase C (PKC)(γ), ‐(β II ), and ‐(α) and the activity of PKC was studied in striatal homogenates of rats subjected to 20 min of cerebral ischemia. (lu.se)
  • Ethanol-induced hypothermia in rats is antagonized by dexamethasone. (bvsalud.org)
  • The effect of dexamethasone on ethanol - induced hypothermia was investigated in 3.5-month old male Wistar rats (N = 10 animals per group). (bvsalud.org)
  • Enhancements in swim stress-induced hypothermia, but not analgesia, following amygdala lesions in rats. (naver.com)
  • The present study addressed this hypothesis by quantitative analysis of ventilatory and carotid chemoreceptor responsiveness to hypoxia during induced hypothermia in halothane anesthetized and spontaneously breathing rats. (elsevier.com)
  • It is concluded that carotid chemoreceptor mediated regulation of ventilation is tightly coupled to changes in Pao 2 range in halothane anesthetized rats during induced hypothermia. (elsevier.com)
  • A combination of mild hypothermia and sevoflurane affords long-term protection in a modified neonatal mouse model of cerebral hypoxia-ischemia. (umassmed.edu)
  • By documenting any injury to acinar cells, they gauged the effect of hypothermia on signaling pathways initiated by cerulein and GTL . (mayoclinic.org)
  • Blocking RBM3 expression in neuronal cells by specific siRNAs significantly diminished the neuroprotective effect of hypothermia while vector-driven RBM3 over-expression reduced cleavage of PARP, prevented internucleosomal DNA fragmentation, and LDH release also in the absence of hypothermia. (uzh.ch)
  • Small numbers, quasi randomisation (according to arrival date), study focussed on ICP and biomarkers to show neuroprotective effect of hypothermia rather than clinically relevant outcomes. (bestbets.org)
  • Hypothermia as much as 10 C. at an ambient temperature of 20 C. is possible, with complete recovery and few, if any, side effects. (google.com)
  • 1. Ischemia induces opening of the blood-brain barrier, a process that seems to be very sensitive to brain temperature [15]. (google.com)
  • Latency shifts could be reversed in hypothyroid animals by increasing the external heat source, and conversely, synaptic delays could be induced in control animals by removing the heat source with a consequent drop in body and brain temperature. (epa.gov)
  • The effect of ambient temperature on cold saline during simulated infusion to induce therapeutic hypothermia. (umassmed.edu)
  • While hypothermia down-regulates global protein synthesis and cell metabolism, low temperature induces a small subset of proteins that includes the RNA-binding protein RBM3 (RNA-binding motif protein 3), which has recently been implicated in cell survival. (uzh.ch)
  • Preterm (0.7 gestation) fetal sheep received complete umbilical cord occlusion for 25 min followed by cerebral hypothermia (fetal extradural temperature reduced from 39.4 +/- 0.3 to 29.5 +/- 2.6 degrees C) from 90 min to 70 h after the end of occlusion or sham cooling. (auckland.ac.nz)
  • The mechanism of protection appears to involve their ability to cross the blood brain barrier, bind to the NT receptor as agonists, and reduce the """"""""set point"""""""" of the central temperature control so that systemic hypothermia in the absence of shivering is promoted. (grantome.com)
  • Its features include normothermia management, controls induced hypothermia and provides precise re-warming, real time dynamic feedback loop from patient to machine, proprietary temperature management algorithms and it supports of wide range of perioperative procedures, both in the paediatric and adult settings. (freethesaurus.com)
  • The protective effect of intraischemic hypothermia may in part be due to the prevention of the ischemia‐induced translocation and subsequent downregulation of PKC, possibly through a temperature‐dependent modification of the cell membranes. (lu.se)
  • In the hypothermia group, the brain temperature decreased to 33-34 degrees C. Brain temperature was maintained at 37 +/- 0.3 degrees C in the normothermia group. (biomedsearch.com)
  • Although the underlying mechanisms have never been completely understood, it is already well accepted that hypothermia decreases brain edema and mitigates the effects of brain ischemia/reperfusion, which are temperature dependent. (hindawi.com)
  • The major advantage of external cooling is that it does not require advanced equipment to induce hypothermia but often requires many hours to reach target temperature and increases the chance of clinical complications such as shivering, pneumonia, and reactive brain edema (due to temperature overshooting). (hindawi.com)
  • Rectal temperature was lowered from 37 °C (normothermia) to 30 and 25 °C by cooling body surface at comparable anesthetic depth without inducing shivering. (elsevier.com)
  • Esophageal temperature was maintained at 38°C in the control and lamotrigine groups, while the temperatures of animals in the hypothermia and hypothermia-plus-lamotrigine groups were cooled to 33°C or 34.5°C. Two 10 minute periods of global cerebral ischemia were produced by inflating a neck tourniquet. (elsevier.com)
  • Hypothermia in fever associated with the above entities is showing promise in that the higher the temperature in the patient, the more damage occurs to the brain and body in general. (hubpages.com)
  • Clinically, peritoneal injury caused by drying has been linked to post-operative pain, evaporative cooling resulting in a decrease in core temperature and increased risk of intra-operative hypothermia, as well as adhesion formation. (wikipedia.org)
  • Surgical hypothermia, defined as a core temperature below 36.0 °C, is associated with increased risk of infectious and non-infections complications, longer post-operative ICU and overall hospital recovery, and more frequent requirement of transfusions. (wikipedia.org)
  • A study published in 2007 found that the Arctic Sun was, "highly effective in lowering patients' temperature rapidly without inducing skin irritations. (wikipedia.org)
  • What are the signs and symptoms of hypothermia? (medicinenet.com)
  • The signs and symptoms of hypothermia vary depending upon how severe the hypothermia becomes. (medicinenet.com)
  • Often, a caregiver will notice if a person is suffering from symptoms of hypothermia, as the condition can cause poor judgement, confusion, and changes in behavior in the person. (wikihow.com)
  • After 3 days recovery the EEG spectral frequency, but not total intensity, was increased in the hypothermia-occlusion group compared with normothermia-occlusion. (auckland.ac.nz)
  • 0.65-0.93,pared therapeutic hypothermia to normothermia for new- respectively).borns with HIE. (slideshare.net)
  • 32 (31%) hypothermia group v 23 (22%) normothermia group. (bestbets.org)
  • 23 (21%) hypothermia group v 14 (12%) normothermia group. (bestbets.org)
  • 1 (8.3%) in the hypothermia group v 2 (20%) in the normothermia group. (bestbets.org)
  • Some 49% of their patients treated with hypothermia were considered to have a 'good' outcome (ie discharged to home or rehabilitation facility) whilst only 26% of those in the normothermia group had the same outcome (P=0.046) . (ispub.com)
  • These are all signs of severe hypothermia. (wikihow.com)
  • Someone with severe hypothermia may appear to be dead, but it's important to call emergency services right away to determine if they are in a state of hypothermia and can still be treated. (wikihow.com)
  • Medical treatment can still be used to resuscitate people with severe hypothermia, though it is not always successful. (wikihow.com)
  • Larger scale trials seem warranted to determine if acetaminophen administration is associated with an increased risk of accidental hypothermia, particularly in vulnerable populations such as frail elderly individuals. (edu.au)
  • However, in the medical and lay literature there are essentially two major classifications, accidental hypothermia and intentional hypothermia . (medicinenet.com)
  • This article will focus on accidental hypothermia. (medicinenet.com)
  • Patients with malnutrition and diabetes mellitus as well as those of advanced age are at high risk for accidental hypothermia . (bvsalud.org)
  • Due to the high mortality rates of accidental hypothermia , proper management is critical for the wellbeing of patients . (bvsalud.org)
  • Accidental hypothermia was reported to be associated with acute kidney injury (AKI) in over 40% of cases. (bvsalud.org)
  • Urgent invasive coronary strategy including coronary angiography and percutaneous coronary intervention (PCI) is feasible and safe in combination with mild induced hypothermia and may significantly improve survival with good neurological outcome in comatose patients after reestablishment of spontaneous circulation (ROSC). (signavitae.com)
  • Besides restarting the heart as soon as possible, only mild induced hypothermia has been shown to improve neurological outcome. (signavitae.com)
  • Clinical and procedural data of 48 patients who underwent percutaneous coronary intervention (PCI) for STEMI after witnessed OHCA were analysed: 24/48 patients were treated with mild induced hypothermia (MTH) and their results were compared to 24 historical controls without cooling. (ahajournals.org)
  • po) administered 30 min before LPS challenge significantly prevented hypothermia. (niscair.res.in)
  • Pretreatment with a-receptor antagonist tolazoline or phenoxybenzamine significantly reduced the hypothermia. (ijp-online.com)
  • The study showed that hypothermia did not significantly reduce the rate of mortality or severe disability but resulted in improved neurologic outcomes in infants assessed at 18 months of age. (springeropen.com)
  • Lesions placed in the rat amygdala significantly reduce analgesic responses induced either by conditioning or exposure to a cat. (naver.com)
  • It is found that ABS-201 caused significant hypothermia effects in monkeys and significantly decreased hypothalamic FC with limbic regions as well. (ismrm.org)
  • 6) There was some excess in pulmonary infections which, however did not compromise the outcome which was significantly better in hypothermia group. (signavitae.com)
  • Hypothermia as used in the case of neonatal asphyxia - whole body or head cooling is performed to 33-34 degrees Centigrade (90-93 degrees Fahrenheit) - begun within 6 hours of birth and continued for 72 hours - significantly reduces mortality and reduces risk of cerebral palsy and neurological defects in surviving infants. (hubpages.com)
  • Rivera-Lara L, Zhang J, Muehlschlegel S. Therapeutic hypothermia for acute neurological injuries. (umassmed.edu)
  • Primary percutaneous coronary intervention and mild induced hypothermia in comatose survivors of ventricular fibrillation with ST-elevation acute myocardial infarction. (freethesaurus.com)
  • MEDLINE/PubMed, CENTRAL, Stroke Center, and ClinicalTrials.gov were systematically searched for hypothermia intervention induced by external or endovascular cooling for acute stroke. (hindawi.com)
  • In animal models, hypothermia also reduces infarct volume, decreases cerebral metabolism, reduces excitotoxicity due to synaptic glutamate overflow, and stabilizes the blood-brain barrier and neuronal membranes, while decreasing cerebral edema in animal models of acute stroke [ 12 - 15 ]. (hindawi.com)
  • The efficacy of hypothermia in acute ischemic stroke (AIS) and traumatic brain injury (TBI), however, is not well studied. (frontiersin.org)
  • Riluzole-Induced Acute Pancreatitis. (ebscohost.com)
  • Presents a letter to the editor about riluzole-induced acute pancreatitis. (ebscohost.com)
  • Acute Pancreatitis Induced by Isoniazid in the Treatment of Tuberculosis. (ebscohost.com)
  • Presents a letter to the editor about acute pancreatitis induced by isoniazid in the treatment of tuberculosis. (ebscohost.com)
  • However, when IAI was followed by hypoxia induced during hypothermia, axonal and vascular protection followed. (biomedsearch.com)
  • Hypothermia will be induced by cold saline infusion as described in appendix 5 [6, 48]. (clinicaltrials.gov)
  • These results demonstrated that ABS 201 induces therapeutic hypothermia in a VFCA rat model, ameliorates postresuscitation myocardial-neurological dysfunction, and prolongs survival duration. (bioportfolio.com)
  • We argue that the myocardium, respiratory rhythmogenic neurons, and possibly other vital tissues depend for their survival during deep hypothermia on this continuing O 2 supply. (springer.com)
  • Hill RW (2000) Anoxia tolerance to oxygen necessity: paradigm shift in the physiology of survival of apneic deep hypothermia in neonatal rodents. (springer.com)
  • Conclusion: Hypothermia improves survival and neu-Intervention: Therapeutic hypothermia. (slideshare.net)
  • Hypothermia in trauma victims: an ominous predictor of survival. (bmj.com)
  • 7.5 Hypothermia and Cold Survival. (wiley.com)
  • In: Dripps RD (ed) The physiology of induced hypothermia. (springer.com)
  • Hypothermia exerts complex effects on human physiology. (frontiersin.org)
  • Maruyama, R & Fukuda, Y 2000, ' Ventilation- and carotid chemoreceptor discharge-response to hypoxia during induced hypothermia in halothane anesthetized rat ', Japanese Journal of Physiology , vol. 50, no. 1, pp. 91-99. (elsevier.com)
  • Anesthesia-Induced Hypothermia (AIH) has been reported to be the cause of many postoperative adverse effects, including increased mortality, decreased immune responses, cardiac events, and a greater p. (bioportfolio.com)
  • A summary of hypothermia-related deaths for the United States during 2003-2013 also is presented for comparison and to assess national mortality trends. (cdc.gov)
  • BACKGROUND: Animal models of serious infection suggest that 24 h of induced hypothermia improves circulatory and respiratory function and reduces mortality. (regionh.dk)
  • Jehle D, Meyer M, Gemme S. Beneficial response to mild therapeutic hypothermia for comatose survivors of near-hanging. (umassmed.edu)
  • Objectives: to evaluate the feasibility, the safety and the effects on physiological parameters of mild therapeutic hypothermia during septic shock. (bioportfolio.com)
  • Patients: twenty ventilated and sedated adults patients with septic shock Intervention: Mild therapeutic hypothermia between 32 and 34°C during 36 consecutive hours using an external water cooling blanket. (bioportfolio.com)
  • Mild Therapeutic Hypothermia Increases Glutathione Levels in Postcardiac Arrest Patients. (bioportfolio.com)
  • Circulatory Arrest, Deep Hypothermia Induced" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (umassmed.edu)
  • This graph shows the total number of publications written about "Circulatory Arrest, Deep Hypothermia Induced" by people in this website by year, and whether "Circulatory Arrest, Deep Hypothermia Induced" was a major or minor topic of these publications. (umassmed.edu)
  • Below are the most recent publications written about "Circulatory Arrest, Deep Hypothermia Induced" by people in Profiles. (umassmed.edu)
  • We present evidence, based particularly on studies of Peromyscus leucopus , that neonatal rodents in deep hypothermia ( T b ≤ 7°C)-although apneic-steadily take up O 2 across the lungs and distribute it via the circulatory system. (springer.com)
  • In regards their steady O 2 uptake and its significance, neonatal rodents resemble rodent hibernators during deep hypothermia. (springer.com)
  • During deep hypothermia, physiologically limited mechanisms of respiratory and circulatory O 2 transport combine to provide neonate tissues with a limited rate of O 2 supply that is vitally important. (springer.com)
  • Adolph EF (1963) How do infant mammals tolerate deep hypothermia? (springer.com)
  • Our ultimate goal is to advance the drug-induced hypothermia therapy to the clinic. (grantome.com)
  • Induced hypothermia is the only therapy with proven efficacy to reduce brain damage after perinatal asphyxia. (uzh.ch)
  • A Comparison of Cooling Methods Used in Therapeutic Hypothermia for Perinatal Asphyxia. (belmontmedtech.com)
  • Introduction of Hypothermia for Neonates with Perinatal Asphyxia in the Netherlands and Flanders. (belmontmedtech.com)
  • Outcome of Infants with Therapeutic Hypothermia after Perinatal Asphyxia and Early-Onset Sepsis. (bioportfolio.com)
  • Animal models suggest that neuroprotective effects of therapeutic hypothermia (TH) after perinatal asphyxia are reduced in infants with early-onset sepsis. (bioportfolio.com)
  • Eleven of the papers reviewed showed strong clinical or meta-analysis evidence for the use of therapeutic hypothermia in adult patients with anoxic/traumatic injuries including CVA and MI, as well as application in the anoxic perinatal infant. (bestbets.org)
  • There are more studies published During the last 2 decades, evidence from since the previous reviews.20-22 The pri- experimental and clinical studies sug- mary objective of this review was to use gests that therapeutic hypothermia re- all the available data, including those from duces cerebral injury and improves neu- the most recently published randomized rological outcome. (slideshare.net)
  • While you consult an ophthalmologist to verify your findings and concentrate on maintaining supportive care, you remember that brain injuries in adults, both hypoxic and traumatic, are increasingly treated with therapeutic hypothermia, and you wonder if this could result in a better outcome for your paediatric patient. (bestbets.org)
  • Thereby, hypothermia may mitigate harm caused by an 'overshoot' of a systemic inflammatory response. (biomedcentral.com)
  • Systemic hypothermia exerts neuroprotective effects in experimental ischemic CNS models caused by vascular occlusions. (nih.gov)
  • The present study addresses the question as to whether systemic hypothermia has similar protective qualities following severe spinal cord compression trauma using beta-APP-, ubiquitin-, and PGP-9.5-immunohistochemistry combined with the ABC complex method as markers to identify axonal changes. (nih.gov)
  • Intra-nasal cooling will be ongoing until systemic hypothermia is started at the intensive care unit. (clinicaltrials.gov)
  • Re- lease of excitotoxic neurotransmitters might also cause progressive neuronal death in the penumbra in stroke patients [22], and hypothermia after cerebral ischemia could attenuate this process. (google.com)
  • Mild hypothermia (32°C) profoundly promoted RBM3 expression and rescued neuronal cells from forced apoptosis as studied in primary neurons, PC12 cells, and cortical organotypic slice cultures. (uzh.ch)
  • Clinicians have a six-hour therapeutic window in which neuronal cell death can be slowed by rapidly cooling the infant, known as therapeutic hypothermia-the only treatment that has been shown to help this condition. (belmontmedtech.com)
  • Anaesthesia generates neuronal insulin resistance by inducing hypothermia. (ulster.ac.uk)
  • Neuronal rescue of encephalopathic newborn infants using induced hypothermia is one of the few therapeutic modalities in neonatology that was studied extensively in animal models before clinical application in humans. (aappublications.org)
  • The cooling capacity of the system is sufficient to induce therapeutic levels of hypothermia in approximately 30 to 90 minutes in most patients. (google.com)
  • Induced hypothermia is now used for some patients undergoing cardiac bypass surgery. (gainesvilletimes.com)
  • The present invention relates to the induction of hypothermia in humans in a predictable and dose responsive fashion by use of a pharmaceutical composition comprising a neurotensin or a neurotensin analog or a synthetic neurotensin or a neurotensin receptor agonist, thereby inducing hypothermia, thus benefiting patients suffering from illnesses characterized by tissue anoxia. (google.com)
  • Six patients (15%) died during hypothermia. (biomedcentral.com)
  • Although the exact role of ischemia/reperfusion is unclear clinically, hypothermia holds significant promise for improving outcomes for patients suffering from reperfusion after ischemia . (citizendium.org)
  • Several important limitations, however, have precluded the widespread use of hypothermia therapy in stroke patients. (grantome.com)
  • This investigation will develop a chemical-induced hypothermia therapy for stroke patients. (grantome.com)
  • The use of therapeutic hypothermia was considered successful in a study of 332 patients in the Netherlands and Flanders where CritiCool was used 8 . (belmontmedtech.com)
  • Aim of the study: To assess the feasibility of pre-hospital therapeutic mild hypothermia in patients successfull. (bioportfolio.com)
  • This study is a prospective, multi-centre, randomized,controlled trial to compare the efficacy of long-term mild hypothermia with normothermic intensive management in patients with poor-gr. (bioportfolio.com)
  • This study is a prospective multi-centre randomized trial to compare the effect of long-term mild hypothermia versus routine normothermic intensive management in patients with severe traum. (bioportfolio.com)
  • UNC REX Hospital is one of several hospitals throughout the country that has begun to use therapeutic hypothermia as an intervention to protect brain function in heart attack patients. (rexhealth.com)
  • The CAST score was developed to predict the neurological outcomes of PCAS patients treated by induced hypothermia. (biomedcentral.com)
  • Prediction of the prognosis of PCAS patients at the time of their arrival in the Emergency Room before the initiation of induced hypothermia will be useful for stratifying patients for precise clinical research, as well as for providing a baseline estimation of their prognosis. (biomedcentral.com)
  • Some studies have examined several factors that are quantifiable before the initiation of induced hypothermia to determine their relationships to the neurological outcomes in PCAS patients. (biomedcentral.com)
  • The aim of the present study was to develop a prognostic scoring system for predicting the neurologic prognosis in PCAS patients treated with induced hypothermia based on the results of examinations carried out prior to the initiation of induced hypothermia. (biomedcentral.com)
  • In conscious, non-intubated patients it can be difficult to induce TH without pharmacological interventions because the human body mounts vigorous thermoregulatory defenses. (frontiersin.org)
  • The body parts most susceptible to injury in patients with hypothermia are those that may suffer from poor circulation or often have the least protection from the cold environment ( feet , hands, nose and ears). (medicinenet.com)
  • Will you be inducing hypothermia in any of your patients? (everydayemstips.com)
  • Induced hypothermia in patients with sep. (regionh.dk)
  • There is preliminary evidence that angiographic result of primary PCI in patients with ST-elevation myocardial infarction (STEMI) after reestablishment of spontaneous circulation (ROSC) is not compromised if mild induced hypothermia is used concomitantly (table 1). (signavitae.com)
  • In patients with trauma, a threshold of 96.8°F (36°C) has been adopted because in this patient group, even milder degrees of hypothermia have devastating consequences in both military and civilian populations. (bmj.com)
  • Nevertheless, we want to highlight medical treatment with drugs which induce vasodilatation as the cornerstone in management of patients with vasospastic angina. (clinmedjournals.org)
  • This audit has been based on the findings of two papers, both of which demonstrated a significant improvement in long term neurological outcomes for patients following induced hypothermia. (ispub.com)
  • Patients that achieve return of spontaneous circulation will be treated with hypothermia according to current guidelines upon arrival at the intensive care unit. (clinicaltrials.gov)
  • Another study, however, returned the same result in that 50% of the patients recovered but only 25% of the patients not treated with hypothermia protocol recovered. (hubpages.com)
  • Barring preventive interventions, hypothermia occurs in more than half of all surgical patients undergoing anesthesia. (wikipedia.org)
  • For many years, elective hypothermia has been induced prior to procedures, such as cardiopulmonary bypass , where it is desirable to reduce oxygen demand and otherwise reduce metabolism. (citizendium.org)
  • Hypothermia may be deliberately induced to slow metabolic processes, as for surgery under cardiopulmonary bypass . (citizendium.org)
  • Hypothermia has been studied in more detail than hyperthermia because of the clinical interest in induced hypothermia during surgery, especially during cardiopulmonary bypass. (freethesaurus.com)
  • There was evidence that hypothermia reduced intracranial pressure (Biswas et al. (bestbets.org)
  • Four hours of whole body hypothermia (32 degrees C), applied immediately after the TBI, attenuated the posttrauma increase in IL-1 beta RNA and eliminated the increase in NGF RNA and protein observed in cerebral cortex following TBI. (nih.gov)
  • Carlsson, D., Harp, J.R., and Siesjä, B.K. (1975): Metabolic changes in the cerebral cortex of the rat induced by intravenous pentothalsodium. (springer.com)
  • The Effects of Pharmacological Hypothermia Induced by Neurotensin Receptor Agonist ABS 201 on Outcomes of CPR. (bioportfolio.com)
  • ABS 201 may therefore be an alternative method to induce therapeutic hypothermia with current cooling methods and improve postresuscitation outcomes. (bioportfolio.com)
  • Among the various methods for hypothermia induction, intravascular cooling (IVC) may have the most promise in the awake patient in terms of clinical outcomes. (frontiersin.org)
  • Comatose survivors of ventricular fibrillation and ST-elevation myocardial infarction undergoing primary percutaneous coronary intervention (PCI) and mild induced hypothermia compared to historical controls undergoing primary PCI but no hypothermia (Adapted from 15). (signavitae.com)
  • Research has elucidated two distinct windows of opportunity for clinical use of hypothermia. (citizendium.org)
  • The comprehensive neuroprotective effects of clinically feasible hypothermia therapy will be studied in two different stroke models, which will facilitate the translation of the therapy to clinical applications. (grantome.com)
  • should consider offering therapeutic hypothermia as part of routine clinical care to these newborns.Results: Seven trials including 1214 newborns were iden-tified. (slideshare.net)
  • However, despite our clinical and experimental experiences, the protective molecular mechanisms of therapeutic hypothermia remain to be elucidated. (springeropen.com)
  • Therefore, in this brief overview we discuss both the clinical evidence and molecular mechanisms of therapeutic hypothermia in order to provide further insights into this promising intervention. (springeropen.com)
  • 3 The purpose of this clinical report is to review briefly the current knowledge regarding the efficacy and safety of therapeutic hypothermia, to point out major gaps in knowledge that were identified at the 2010 workshop, and to suggest a framework for the implementation of hypothermia. (aappublications.org)
  • The neuroprotective efficacy of induced hypothermia following or during ischemia of the brain is evident in experimental animal models of stroke [1 -1 1]. (google.com)
  • This is evident from studies of tracers and their migration across the blood-brain barrier, in which hypothermia attenuates extravasation several hours after ischemia [16] and prevents vasogenic oedema [17]. (google.com)
  • Hypothermia prevents the production of free radicals such as hydroxyl and nitric oxide during reperfusion after brain ischemia [19;20]. (google.com)
  • Hypothermic exposure either before or after permanent middle cerebral artery occlusion (pMCAO) surgery in wild type mice increased global SUMO-conjugation levels in the brain and in so doing protected these animals from pMCAO-induced ischemic damage. (frontiersin.org)
  • Of note, hypothermic exposure did not provide an additional increase in protection from pMCAO-induced ischemic brain damage in Ubc9 transgenic (Ubc9 Tg) mice, which overexpress the sole E2 SUMO conjugating enzyme and thereby display elevated basal levels of global SUMOylation under normothermic conditions. (frontiersin.org)
  • Such evidence suggests that increases in global SUMOylation are critical and may account for a substantial part of the observed increase in cellular tolerance to brain ischemia caused via hypothermia. (frontiersin.org)
  • One candidate capable of coordinating the multimodal molecular mechanisms that underlie the cytoprotection induced in the brain as a consequence of cooling is that of global SUMOylation. (frontiersin.org)
  • Neurotensin is an endogenous tridecapeptide that binds to neurotensin receptors in the brain, which induce hypothermia. (bioportfolio.com)
  • We conclude that rewarming from therapeutic hypothermia can adversely affect the newborn brain by inducing apoptosis through caspase mechanisms. (elsevier.com)
  • Thus, hypothermia may be an effective therapy to diminish the posttrauma inflammatory cascade in the brain (as suggested by the decrease in IL-1 beta). (nih.gov)
  • The adverse pial arteriolar and axonal consequences of traumatic brain injury complicated by hypoxia and their therapeutic modulation with hypothermia in rat. (biomedsearch.com)
  • Mellen NM, Milsom WK, Feldman JL (2002) Hypothermia and recovery from respiratory arrest in a neonatal rat in vitro brain stem preparation. (springer.com)
  • RESULTS: We find that urethane- and ketamine-induced anaesthesia results in rapid activation of the phosphatidylinositol (PI) 3-kinase-protein kinase B (PKB) signalling pathway in the brain, increases tau phosphorylation while at the same time reducing basal activity of the Ras-ERK pathway. (ulster.ac.uk)
  • Linares and Mayer, 2009 ), which raised the possibility that hypothermia provided a neuroprotective effect in the case of anoxic brain injury ( Linares and Mayer, 2009 ). (frontiersin.org)
  • This has been taken as an indication that hypothermia has a neuroprotective effect after traumatic brain injury. (bestbets.org)
  • Then in the 1950s, hypothermia was used in an aneurysm surgery on the brain to effectively create a bloodless field so they could operate. (hubpages.com)
  • By the 1980s, animal studies were showing that there were neurologically protective properties following blockage of blood flow to the brain by mild hypothermia. (hubpages.com)
  • Hypothermia in traumatic brain and spinal injuries is also in the animal investigational stages but it is showing promise in preventing the secondary effects that occur from severe trauma to the brain or spinal cord - for the same reasons cited above. (hubpages.com)
  • Studying brain regional discrepancies in offspring might help to know the prenatal stress-induced variation in the antioxidant barrier and promoted oxidative stress. (who.int)
  • The present invention relates to the use of compounds for the induction of hypothermia, such as for the prophylaxis and treatment of ischemia. (google.com)
  • Herein we demonstrate that global SUMOylation, a form of post-translational modification with the Small Ubiquitin-like MOdifer, participates in the multimodal molecular induction of hypothermia-induced ischemic tolerance. (frontiersin.org)
  • Mild Hypothermia Prevents NO-Induced Cytotoxicity in Human Neuroblastoma Cells Via Induction of COX-2. (bioportfolio.com)
  • During induction phase of hypothermia [ 10 ], decreasing serum levels of magnesium are warranted with high risk of arterial spasm due to higher intracellular levels of calcium in smooth muscle fibers. (clinmedjournals.org)
  • The risk of developing hypothermia increases if you are exhausted or dehydrated. (wikihow.com)
  • Induced hypothermia is increasingly applied as a therapeutic intervention in ICUs. (biomedcentral.com)
  • In this study we hypothesize that blocking the angiotensin II AT1-receptor improves the insulin-induced microvascular dilatation. (bioportfolio.com)
  • In this patient group, even milder degrees of hypothermia have devastating consequences in both military and civilian populations. (bmj.com)
  • They began to investigate milder forms of hypothermia (32-34 degrees Centigrade or 90-93 degrees Fahrenheit) in the 1950s. (hubpages.com)
  • Newborns, infants, and young children are more likely to develop hypothermia because they have a larger surface area compared to body weight so they can lose body heat faster than older children and adults. (rxlist.com)
  • At present, induced hypothermia has yet to be recognized or approved as a potential treatment having therapeutic value for traumatic SCI in humans. (curehunter.com)
  • In 1952 at the University of Minnesota, Dr. John Lewis closed an atrial septal defect in a 5-year-old girl using total-body hypothermia. (frontiersin.org)
  • Moreover, neonates lose sinoatrial (SA) pacing of ventricular contraction on entry to hypothermia and depend on quasi-rhythmic ventricular escape contractions to maintain cardiac activity. (springer.com)
  • ER doctors induced hypothermia, and the treatment was continued in the intensive-care unit, for about 36 hours. (gainesvilletimes.com)
  • Two registered nurses at Memorial, Theresa Jones and Linda Yusko, worked to help bring the therapeutic hypothermia treatment to Springfield. (lincolncourier.com)
  • The therapeutic hypothermia treatment at Memorial uses a Gaymar machine similar to the one at St. John's. (lincolncourier.com)
  • Kevin Hall is doing better after the hypothermia treatment, followed by stent procedures for his heart and a toe amputation at St. John's. (lincolncourier.com)
  • Hypothermia has been suggested as a possible treatment to lessen or suppress these inflammatory reactions. (nih.gov)
  • Optimal treatment may, therefore, require supplemental administration of neurotrophic factors or other agents along with hypothermia. (nih.gov)
  • Induced hypothermia as salvage treatment for refractory cardiac failure following paediatric cardiac surgery. (freethesaurus.com)
  • Lougheed , W. M. , , Sweet , W. H. , , White , J. C. , and & Brewster , W. R. The use of hypothermia in surgical treatment of cerebral vascular lesions. (thejns.org)
  • The use of hypothermia in surgical treatment of cerebral vascular lesions. (thejns.org)
  • Effective standardization has not been applied to therapeutic hypothermia trials to test consistent changes in: window of time to start treatment, duration of treatment, and rate of re-warming. (bestbets.org)
  • The first medical article published about hypothermia as a treatment was published in 1945. (hubpages.com)
  • 5. By lowering of neutrophil and microglial activation after ischemia, hypothermia also has an anti-inflammatory effect [30;31]. (google.com)
  • As such, hypothermia has been shown to alter a number of the pathologic molecular mechanisms induced by cerebral ischemia. (frontiersin.org)
  • Optimal timing of therapeutic hypothermia for cardiac ischemia is unknown. (elsevier.com)
  • Thus we hypothesized that hypothermia will protect most using extended ischemia and early reperfusion cooling and is mediated via PKC and NO synthase (NOS). (elsevier.com)
  • In conclusion, therapeutic hypothermia initiated during extended ischemia/early reperfusion optimally protects cardiomyocytes from I/R injury. (elsevier.com)
  • Koinig, H, Morimoto, Y & Zornow, MH 2001, ' The combination of lamotrigine and mild hypothermia prevents ischemia-induced increase in hippocampal glutamate ', Journal of Neurosurgical Anesthesiology , vol. 13, no. 2, pp. 106-112. (elsevier.com)
  • The first half hour after the person's symptoms become clear are the most critical phase of hypothermia management. (wikihow.com)