Hypothermia, Induced: Abnormally low BODY TEMPERATURE that is intentionally induced in warm-blooded animals by artificial means. In humans, mild or moderate hypothermia has been used to reduce tissue damages, particularly after cardiac or spinal cord injuries and during subsequent surgeries.Hypothermia: Lower than normal body temperature, especially in warm-blooded animals.Rewarming: Application of heat to correct hypothermia, accidental or induced.Body Temperature: The measure of the level of heat of a human or animal.Hypoxia-Ischemia, Brain: A disorder characterized by a reduction of oxygen in the blood combined with reduced blood flow (ISCHEMIA) to the brain from a localized obstruction of a cerebral artery or from systemic hypoperfusion. Prolonged hypoxia-ischemia is associated with ISCHEMIC ATTACK, TRANSIENT; BRAIN INFARCTION; BRAIN EDEMA; COMA; and other conditions.Heart Arrest: Cessation of heart beat or MYOCARDIAL CONTRACTION. If it is treated within a few minutes, heart arrest can be reversed in most cases to normal cardiac rhythm and effective circulation.Body Temperature Regulation: The processes of heating and cooling that an organism uses to control its temperature.Circulatory Arrest, Deep Hypothermia Induced: A technique to arrest the flow of blood by lowering BODY TEMPERATURE to about 20 degrees Centigrade, usually achieved by infusing chilled perfusate. The technique provides a bloodless surgical field for complex surgeries.Asphyxia Neonatorum: Respiratory failure in the newborn. (Dorland, 27th ed)Shivering: Involuntary contraction or twitching of the muscles. It is a physiologic method of heat production in man and other mammals.Cardiopulmonary Resuscitation: The artificial substitution of heart and lung action as indicated for HEART ARREST resulting from electric shock, DROWNING, respiratory arrest, or other causes. The two major components of cardiopulmonary resuscitation are artificial ventilation (RESPIRATION, ARTIFICIAL) and closed-chest CARDIAC MASSAGE.Coma: A profound state of unconsciousness associated with depressed cerebral activity from which the individual cannot be aroused. Coma generally occurs when there is dysfunction or injury involving both cerebral hemispheres or the brain stem RETICULAR FORMATION.Cold Temperature: An absence of warmth or heat or a temperature notably below an accustomed norm.Heart Arrest, Induced: A procedure to stop the contraction of MYOCARDIUM during HEART SURGERY. It is usually achieved with the use of chemicals (CARDIOPLEGIC SOLUTIONS) or cold temperature (such as chilled perfusate).Brain Injuries: Acute and chronic (see also BRAIN INJURIES, CHRONIC) injuries to the brain, including the cerebral hemispheres, CEREBELLUM, and BRAIN STEM. Clinical manifestations depend on the nature of injury. Diffuse trauma to the brain is frequently associated with DIFFUSE AXONAL INJURY or COMA, POST-TRAUMATIC. Localized injuries may be associated with NEUROBEHAVIORAL MANIFESTATIONS; HEMIPARESIS, or other focal neurologic deficits.Time Factors: Elements of limited time intervals, contributing to particular results or situations.Brain Ischemia: Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.Out-of-Hospital Cardiac Arrest: Occurrence of heart arrest in an individual when there is no immediate access to medical personnel or equipment.Heating: The application of heat to raise the temperature of the environment, ambient or local, or the systems for accomplishing this effect. It is distinguished from HEAT, the physical property and principle of physics.Cardiopulmonary Bypass: Diversion of the flow of blood from the entrance of the right atrium directly to the aorta (or femoral artery) via an oxygenator thus bypassing both the heart and lungs.Hypoxia, Brain: A reduction in brain oxygen supply due to ANOXEMIA (a reduced amount of oxygen being carried in the blood by HEMOGLOBIN), or to a restriction of the blood supply to the brain, or both. Severe hypoxia is referred to as anoxia, and is a relatively common cause of injury to the central nervous system. Prolonged brain anoxia may lead to BRAIN DEATH or a PERSISTENT VEGETATIVE STATE. Histologically, this condition is characterized by neuronal loss which is most prominent in the HIPPOCAMPUS; GLOBUS PALLIDUS; CEREBELLUM; and inferior olives.Extracorporeal Circulation: Diversion of blood flow through a circuit located outside the body but continuous with the bodily circulation.Resuscitation: The restoration to life or consciousness of one apparently dead. (Dorland, 27th ed)Brain: The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.Asphyxia: A pathological condition caused by lack of oxygen, manifested in impending or actual cessation of life.Skin Temperature: The TEMPERATURE at the outer surface of the body.Treatment Outcome: Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.Rats, Sprague-Dawley: A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.Disease Models, Animal: Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.Intracranial Pressure: Pressure within the cranial cavity. It is influenced by brain mass, the circulatory system, CSF dynamics, and skull rigidity.Intraoperative Complications: Complications that affect patients during surgery. They may or may not be associated with the disease for which the surgery is done, or within the same surgical procedure.Infant, Newborn: An infant during the first month after birth.Buspirone: An anxiolytic agent and serotonin receptor agonist belonging to the azaspirodecanedione class of compounds. Its structure is unrelated to those of the BENZODIAZAPINES, but it has an efficacy comparable to DIAZEPAM.Electroencephalography: Recording of electric currents developed in the brain by means of electrodes applied to the scalp, to the surface of the brain, or placed within the substance of the brain.Hyperthermia, Induced: Abnormally high temperature intentionally induced in living things regionally or whole body. It is most often induced by radiation (heat waves, infra-red), ultrasound, or drugs.Gastric Hypothermia: A method of lowering core BODY TEMPERATURE by filling the STOMACH with chilled fluids.Temperature: The property of objects that determines the direction of heat flow when they are placed in direct thermal contact. The temperature is the energy of microscopic motions (vibrational and translational) of the particles of atoms.Neuroprotective Agents: Drugs intended to prevent damage to the brain or spinal cord from ischemia, stroke, convulsions, or trauma. Some must be administered before the event, but others may be effective for some time after. They act by a variety of mechanisms, but often directly or indirectly minimize the damage produced by endogenous excitatory amino acids.Pentobarbital: A short-acting barbiturate that is effective as a sedative and hypnotic (but not as an anti-anxiety) agent and is usually given orally. It is prescribed more frequently for sleep induction than for sedation but, like similar agents, may lose its effectiveness by the second week of continued administration. (From AMA Drug Evaluations Annual, 1994, p236)Pargyline: A monoamine oxidase inhibitor with antihypertensive properties.Cerebrovascular Circulation: The circulation of blood through the BLOOD VESSELS of the BRAIN.Meperidine: A narcotic analgesic that can be used for the relief of most types of moderate to severe pain, including postoperative pain and the pain of labor. Prolonged use may lead to dependence of the morphine type; withdrawal symptoms appear more rapidly than with morphine and are of shorter duration.Intraoperative Care: Patient care procedures performed during the operation that are ancillary to the actual surgery. It includes monitoring, fluid therapy, medication, transfusion, anesthesia, radiography, and laboratory tests.Ventricular Fibrillation: A potentially lethal cardiac arrhythmia that is characterized by uncoordinated extremely rapid firing of electrical impulses (400-600/min) in HEART VENTRICLES. Such asynchronous ventricular quivering or fibrillation prevents any effective cardiac output and results in unconsciousness (SYNCOPE). It is one of the major electrocardiographic patterns seen with CARDIAC ARREST.Near Drowning: Non-fatal immersion or submersion in water. The subject is resuscitable.Rats, Wistar: A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain.Anesthesia: A state characterized by loss of feeling or sensation. This depression of nerve function is usually the result of pharmacologic action and is induced to allow performance of surgery or other painful procedures.Fever: An abnormal elevation of body temperature, usually as a result of a pathologic process.Myxedema: A condition characterized by a dry, waxy type of swelling (EDEMA) with abnormal deposits of MUCOPOLYSACCHARIDES in the SKIN and other tissues. It is caused by a deficiency of THYROID HORMONES. The skin becomes puffy around the eyes and on the cheeks. The face is dull and expressionless with thickened nose and lips.Yawning: An involuntary deep INHALATION with the MOUTH open, often accompanied by the act of stretching.Naegleria fowleri: A species of parasitic protozoa having both an ameboid and flagellate stage in its life cycle. Infection with this pathogen produces PRIMARY AMEBIC MENINGOENCEPHALITIS.

Reduction of laparoscopic-induced hypothermia, postoperative pain and recovery room length of stay by pre-conditioning gas with the Insuflow device: a prospective randomized controlled multi-center study. (1/754)

OBJECTIVE: To assess the efficacy and safety of Insuflow (Georgia BioMedical, Inc.) filter heater hydrator device in reducing the incidence, severity and extent of hypothermia, length of recovery room stay and postoperative pain at the time of laparoscopy. DESIGN: Prospective, randomized, blinded, controlled multi-center study. Patients underwent gynecologic procedures via laparoscopy; surgeons, anesthesiologists and recovery room personnel assessed the results. SETTING: Seven North American institutions. PATIENTS: Seventy-two women for safety evaluation and efficacy studies. INTERVENTIONS: Intraoperative pre-conditioning of laparoscopic gas with the Insuflow device (treatment) or standard raw gas (control) during laparoscopic surgery and postoperatively. MAIN OUTCOME MEASURES: Incidence, severity and extent of hypothermia, postoperative pain perception and length of recovery room stay. RESULTS: The Insuflow group had significantly less intraoperative hypothermia, reduced length of recovery room stay and reduced postoperative pain. Pre-conditioning of laparoscopic gas by filtering heating and hydrating was well tolerated with no adverse effects. The safety profile of the Insuflow pre-conditioned gas showed significant benefits compared to currently used raw gas. CONCLUSIONS: Pre-conditioning laparoscopic gas by filtering heating and hydrating with the Insuflow device was significantly more effective than the currently used standard raw gas and was safe in reducing or eliminating laparoscopic-induced hypothermia, shortening recovery room length of stay and reducing postoperative pain.  (+info)

The effect of graded postischemic spinal cord hypothermia on neurological outcome and histopathology after transient spinal ischemia in rat. (2/754)

BACKGROUND: Previous data have shown that postischemic brain hypothermia is protective. The authors evaluated the effect of postischemic spinal hypothermia on neurologic function and spinal histopathologic indices after aortic occlusion in the rat. METHODS: Spinal ischemia was induced by aortic occlusion lasting 10 min. After ischemia, spinal hypothermia was induced using a subcutaneous heat exchanger. Three studies were conducted. In the first study, the intrathecal temperature was decreased to 34, 30, or 27 degrees C for 2 h beginning with initial reperfusion. In the second study, hypothermia (target intrathecal temperature 27 degrees C) was initiated with reflow and maintained for 15 or 120 min. In the third study, the intrathecal temperature was decreased to 27 degrees C for 2 h starting 5, 60, or 120 min after normothermic reperfusion. Animals survived for 2 or 3 days, at which time they were examined and perfusion fixed with 4% paraformaldehyde. RESULTS: Normothermic ischemia followed by normothermic reflow resulted in spastic paraplegia and spinal neuronal degeneration. Immediate postischemic hypothermia (27 degrees C for 2 h) resulted in decreasing motor dysfunction. Incomplete protection was noted at 34 degrees C. Fifteen minutes of immediate cooling (27 degrees C) also provided significant protection. Delay of onset of post-reflow hypothermia (27 degrees C) by 5 min or more failed to provide protection. Histopathologic analysis revealed temperature-dependent suppression of spinal neurodegeneration, with no effect of delayed cooling. CONCLUSIONS: These findings indicate that the immediate period of reperfusion (0-15 min) represents a critical period that ultimately defines the degree of spinal neuronal degeneration. Hypothermia, when initiated during this period, showed significant protection, with the highest efficacy observed at 27 degrees C.  (+info)

Perinatal risk and severity of illness in newborns at 6 neonatal intensive care units. (3/754)

OBJECTIVES: This multisite study sought to identify (1) any differences in admission risk (defined by gestational age and illness severity) among neonatal intensive care units (NICUs) and (2) obstetric antecedents of newborn illness severity. METHODS: Data on 1476 babies born at a gestational age of less than 32 weeks in 6 perinatal centers were abstracted prospectively. Newborn illness severity was measured with the Score for Neonatal Acute Physiology. Regression models were constructed to predict scores as a function of perinatal risk factors. RESULTS: The sites differed by several obstetric case-mix characteristics. Of these, only gestational age, small for gestational age. White race, and severe congenital anomalies were associated with higher scores. Antenatal corticosteroids, low Apgar scores, and neonatal hypothermia also affected illness severity. At 2 sites, higher mean severity could not be explained by case mix. CONCLUSIONS: Obstetric events and perinatal practices affect newborn illness severity. These risk factors differ among perinatal centers and are associated with elevated illness severity at some sites. Outcomes of NICU care may be affected by antecedent events and perinatal practices.  (+info)

Hypothermic stress leads to activation of Ras-Erk signaling. (4/754)

The small GTPase Ras is converted to the active, GTP-bound state during exposure of vertebrate cells to hypothermic stress. This activation occurs more rapidly than can be accounted for by spontaneous nucleotide exchange. Ras-guanyl nucleotide exchange factors and Ras GTPase-activating proteins have significant activity at 0 degrees C in vitro, leading to the hypothesis that normal Ras regulators influence the relative amounts of Ras-GTP and Ras-GDP at low temperatures in vivo. When hypothermic cells are warmed to 37 degrees C, the Raf-Mek-Erk protein kinase cascade is activated. After prolonged hypothermic stress, followed by warming to physiologic temperature, cultured fibroblasts assume a rounded morphology, detach from the substratum, and die. All of these biologic responses are attenuated by pharmacologic inhibition of Mek. Previously, it had been found that low temperature blocks acute growth factor signaling to Erk. In the present study, we found that this block occurs at the level of Raf activation. Temperature regulation of Ras signaling could help animal cells respond appropriately to hypothermic stress, and Ras-Erk signaling can be manipulated to improve the survival of cells in cold storage.  (+info)

Hypothermia: a complication of diabetic ketoacidosis. (5/754)

During 1969-77, 20 episodes of severe hypothermia occurred in 19 diabetic patients in Nottingham. Thirteen were associated with ketotic hyperosmolar coma, two with lactic acidosis, and one with hypoglycaemia, while in four there was no loss of diabetic control. Ketoacidosis accounted for 11.8% of all admissions for severe accidental hypothermia and was a commoner cause than hypothyroidism (8%). Patients with ketoacidosis were younger and developed hypothermia as often during the summer as during the winter. The metabolic disturbance was characteristic, with severe acidosis (mean pH 7.04), a high blood glucose concentration (mean 56.6 mmol/l; 1020 mg/100 ml), and high plasma osmolality (mean 379.7 mmol (mosmol)/kg). Eight of the 13 episodes proved fatal. Hypothermia may aggravate ketoacidosis and complicate treatment and should be sought in all patients with severe diabetic coma.  (+info)

F 11356, a novel 5-hydroxytryptamine (5-HT) derivative with potent, selective, and unique high intrinsic activity at 5-HT1B/1D receptors in models relevant to migraine. (6/754)

F 11356 (4-[4-[2-(2-aminoethyl)-1H-indol-5-yloxyl]acetyl]piperazinyl-1-yl] ben zonitrile) was designed to take advantage of the superior potency and efficacy characteristics of 5-hydroxytryptamine (5-HT) compared with tryptamine at 5-HT1B/1D receptors. F 11356 has subnanomolar affinity for cloned human and nonhuman 5-HT1B and 5-HT1D receptors, and its affinity for 5-HT1A and other 5-HT receptors, including the 5-ht1F subtype, is 50-fold lower and micromolar, respectively. In C6 cells expressing human 5-HT1B or human 5-HT1D receptors, F 11356 was the most potent compound in inhibiting forskolin-induced cyclic AMP formation (pD2 = 8.9 and 9.6), and in contrast to tryptamine and derivatives, it produced maximal enhancement of [35S]guanosine-5'-O-(3-thio)triphosphate-specific binding equivalent to 5-HT. F 11356 was equipotent to 5-HT (pD2 = 7.1 versus 7.2) and more potent than tryptamine derivatives in contracting rabbit isolated saphenous vein. In isolated guinea pig trigeminal ganglion neurons, F 11356 was more potent (pD2 = 7.3 versus 6.7) and induced greater increases in outward hyperpolarizing Ca2+-dependent K+ current than sumatriptan. In anesthetized pigs, F 11356 elicited highly cranioselective, more potent (from 0.16 microgram/kg i.v.) and greater carotid vasoconstriction than tryptamine derivatives. Decreases in carotid blood flow were observed in conscious dogs from 0.63 mg/kg oral F 11356 in the absence of changes in heart rate or behavior. Oral activity was confirmed when hypothermic responses were elicited in guinea pigs (ED50 = 1.6 mg/kg), suggesting that F 11356 also accesses the brain. F 11356 thus is a selective, high-potency agonist at 5-HT1B/1D receptors, which distinguishes itself from tryptamine and derivatives in exerting high intrinsic activity at these receptors in vascular and neuronal models relevant to migraine.  (+info)

Humanization of mouse 5-hydroxytryptamine1B receptor gene by homologous recombination: in vitro and in vivo characterization. (7/754)

We replaced the coding region of the murine 5-hydroxytryptamine (5-HT)1B receptor by the human 5-HT1B receptor using homologous recombination in embryonic stem cells and generated and characterized homozygous transgenic mice that express only the human (h) 5-HT1B receptor. The distribution patterns of h5-HT1B and murine (m) 5-HT1B receptor mRNA and binding sites in brain sections of transgenic and wild-type mice were identical as measured by in situ hybridization histochemistry and radioligand receptor autoradiography. When measured in parallel under identical conditions, the h5-HT1B receptor expressed in mouse brain had the same pharmacological characteristics as that in human brain. Stimulation by 5-HT1B agonists of [35S]guanosine-5'-O-(3-thio)triphosphate binding in brain sections demonstrated the functional coupling of the h5-HT1B receptor to G proteins in mouse brain. In tissue slices from various brain regions, electrically stimulated [3H]5-HT release was not modified by 5-HT1B agonists in tissue from either transgenic and wild-type mice; a 5-HT1B antagonist enhanced electrically stimulated [3H]5-HT release in wild-type mouse brain, but was ineffective in the transgenics. The centrally active 5-HT1A/5-HT1B agonist RU24969 induced hypothermia but did not increase locomotor activity in the transgenic mice. The ineffectiveness of RU24969 in the transgenic mice could be due to the lower affinity of the compound for the h5-HT1B receptor compared with the m5-HT1B receptor. The present study demonstrates a complete replacement of the mouse receptor by its human receptor homolog and a functional coupling to G proteins. However, modulation of [3H]5-HT release could not be shown. Furthermore, behavioral effects were not clearly observed, which may be due to a lack of appropriate tools.  (+info)

Acute systemic reaction and lung alterations induced by an antiplatelet integrin gpIIb/IIIa antibody in mice. (8/754)

Shock is frequently accompanied by thrombocytopenia. To investigate the pathogenic role of platelets in shock, we examined the in vivo effects of monoclonal antibodies (MoAbs) against mouse platelet membrane proteins. Injection of the platelet-specific MoAb MWReg30 to the fibrinogen receptor (gpIIb/IIIa) rendered mice severely hypothermic within minutes. Isotype-matched control antibodies, even if they also recognized platelet surface antigens, did not induce comparable signs. MWReg30 induced early signs of acute lung injury with increased cellularity in the lung interstitium and rapid engorgement of alveolar septal vessels. Despite this in vivo activity, MWReg30 inhibited rather than stimulated platelet aggregation in vitro. MWReg30-binding to platelets led to phosphorylation of gpIIIa, but did not induce morphological signs of platelet activation. The MWReg30-induced reaction was abolished after treatment with MoAbs 2.4G2 to FcgammaRII/III and was absent in FcgammaRIII-deficient mice, clearly demonstrating the requirement for FcgammaRIII on involved leukocytes. Simultaneous administration of tumor necrosis factor exacerbated, whereas a tolerizing regimen of tumor necrosis factor or bacterial lipopolysaccharide completely prevented the reaction. These data suggest that platelet surface-deposited MWReg30-immune complexes lead to an acute Fc-mediated reaction with pulmonary congestion and life-threatening potential that could serve as an in vivo model of acute lung injury.  (+info)

  • A systematic review on the effectiveness of prewarming to prevent perioperative hypothermia. (nih.gov)
  • To analyse available research on the effectiveness of prewarming to prevent perioperative hypothermia and identify knowledge gaps for future research. (nih.gov)
  • In this context, several methods have been investigated to prevent perioperative hypothermia, including prewarming. (nih.gov)
  • We searched CINAHL, EMBASE, Cochrane Register of Controlled Trials and Medline (January 1990-November 2011) for randomised controlled trials on the effectiveness of prewarming for prevention of perioperative hypothermia, published in English, Spanish and Portuguese, and involving elective surgery patients aged 18 years or older. (nih.gov)
  • Prewarming patients with the forced-air warming system might be effective to reduce perioperative hypothermia, and new studies are needed to examine the use of carbon fibre technology. (nih.gov)
  • Perioperative hypothermia (PH) is a preventable, pathological, and iatrogenic state that has been shown to result in increased surgical blood loss, increased surgical site infections, increased hospital length of stay, and patient discomfort. (thejns.org)
  • 7 February 2017 HumiGard for preventing inadvertent perioperative hypothermia (NICE medical technologies guidance 31) added to temperature recording and warming devices . (nice.org.uk)
  • The plaintiff is alleging that the responders failed to perform an assessment, failed to follow their own policy and procedures for hypothermia victims in cardiac arrest and essentially abandoned the patient contributing to his death. (ems1.com)
  • Miracle' woman Audrey Schoeman survived a six-hour cardiac arrest after developing hypothermia while hiking during a snowstorm in the Spanish Pyrenees. (ctvnews.ca)
  • Recommendations amended in line with the update of NICE guideline CG65 on hypothermia: prevention and management in adults having surgery. (nice.org.uk)
  • Manner of hypothermia (water, wind/air, snow) had no impact on survival rates. (ems1.com)
  • The results suggest that forced-air warming system is effective to reduce hypothermia when applied for the prewarming of surgical patients. (nih.gov)
  • Hypothermia death of a Minn. teen is an unimaginable tragedy, but a breach is not enough for a finding of negligence. (ems1.com)
  • These effects were regulated in the brain, as only central, not peripheral, pharmacological activation of IGF-1R prevented hypothermia during calorie restriction. (pnas.org)
  • Infants with hypothermia may feel cold when touched, with bright red skin and an unusual lack of energy. (wikipedia.org)
  • The current data from randomized control trials of hypothermia as neuroprotection for full-term infants will be presented along with the results of meta-analyses of these trials. (nih.gov)
  • Newborns, infants, and young children are more likely to develop hypothermia because they have a larger surface area compared to body weight so they can lose body heat faster than older children and adults. (rxlist.com)
  • Infants and older adults have the highest risk of developing hypothermia. (healthline.com)
  • Nevertheless, many infants still survive with disability, despite hypothermia, supporting further research in to ways to further improve neurologic outcomes. (springer.com)
  • A current National Institute of Child Health and Human Development (NICHD) study is evaluating the efficacy of delayed hypothermia therapy for infants presenting at referral centers beyond 6 hours of life or with evolving encephalopathy. (medscape.com)
  • Neuronal rescue of encephalopathic newborn infants using induced hypothermia is one of the few therapeutic modalities in neonatology that was studied extensively in animal models before clinical application in humans. (aappublications.org)
  • 4 After showing consistent benefit in animal models, the safety, feasibility, and practicality of using induced hypothermia in infants who have neonatal encephalopathy were investigated in several small studies. (aappublications.org)
  • Hypothermia as used in the case of neonatal asphyxia - whole body or head cooling is performed to 33-34 degrees Centigrade (90-93 degrees Fahrenheit) - begun within 6 hours of birth and continued for 72 hours - significantly reduces mortality and reduces risk of cerebral palsy and neurological defects in surviving infants. (hubpages.com)
  • Outcome of Infants with Therapeutic Hypothermia after Perinatal Asphyxia and Early-Onset Sepsis. (bioportfolio.com)
  • A May 31 report in the New England Journal of Medicine ( NEJM ) provided seven-year follow-up results from a study that compared infants who underwent whole-body hypothermia for neonatal hypoxic-ischemic encephalopathy with comparable infants who received usual care. (lww.com)
  • These data extend our previous support for the use of hypothermia in term and near-term infants with hypoxic-ischemic encephalopathy. (lww.com)
  • Infants were randomly assigned to usual care or to hypothermia at 33.5 degrees Celsius for 72 hours. (lww.com)
  • Neonatal encephalopathy: treatment with hypothermia. (nih.gov)
  • In this article, the role of hypothermia and neuroprotection for neonatal encephalopathy will be discussed. (nih.gov)
  • Further research is essential to find and evaluate ways to further improve outcomes after hypoxic-ischemic encephalopathy, including add-on therapies for therapeutic hypothermia and preventing pyrexia during labor and delivery. (springer.com)
  • When should hypothermia therapy be initiated for hypoxic-ischemic encephalopathy (HIE)? (medscape.com)
  • Data from large randomized clinical trials indicate that therapeutic hypothermia, using either selective head cooling or systemic cooling, is an effective therapy for neonatal encephalopathy. (aappublications.org)
  • Six large randomized clinical trials of induced hypothermia for neonatal encephalopathy were published from 2005 to 2011. (aappublications.org)
  • Hypothermia for Neonatal Encephalopathy Lowers Death Rate Wi. (lww.com)
  • Longer-term data confirms that whole-body hypothermia reduces the rate of death stemming from neonatal encephalopathy without increasing the rate of low IQ scores or severe disability among babies who survive. (lww.com)
  • Dr. Shankaran said that before the emergence of hypothermia as a therapeutic option the death rate for babies who were moderately to severely affected by hypoxic-ischemic encephalopathy ranged from 30-70 percent. (lww.com)
  • Hypothermia therapy became standard in neonatal units in the US and some other countries in recent years after research showed that cooling has a protective effect on the brains of term babies with hypoxic-ischemic encephalopathy. (lww.com)
  • Set your thermostat to at least 68 to 70 degrees Fahrenheit (F). Even mildly cool homes with temperatures from 60 to 65 degrees F can lead to hypothermia in older adults. (nih.gov)
  • Harris said she sees few life-threatening hypothermia cases, but there are degrees of hypothermia, and many people might have a mild form of the condition that they never even seek treatment for. (ctpost.com)
  • They began to investigate milder forms of hypothermia (32-34 degrees Centigrade or 90-93 degrees Fahrenheit) in the 1950s. (hubpages.com)
  • Dehydration makes you more prone to hypothermia. (runnersworld.com)
  • Social service agencies can help people who are prone to hypothermia, such as the elderly or the homeless, find housing, heat, and clothing. (umm.edu)
  • Staying indoors, eating regularly and consuming plenty of carbohydrates especially, keeping active and by avoiding alcohol, caffeine and nicotine (these dilate the blood vessels further, increasing the heat loss) and wearing layers of clothing in order to keep the heat trapped inside are all the ways that you can follow in order to reduce the risk of getting prone to hypothermia. (ayushveda.com)
  • What body parts are more susceptible to hypothermia? (medicinenet.com)
  • The internal organ most susceptible to hypothermia is the heart (dysrhythmias). (medicinenet.com)
  • This decrease in fluid level makes the body more susceptible to hypothermia and other cold injuries. (princeton.edu)
  • Unfortunately, because vulnerable people are susceptible to hypothermia this sort of incident is not uncommon. (cqc.org.uk)
  • While hypothermia is most likely at very cold temperatures, it can occur even at cool temperatures (above 40°F) if a person becomes chilled from rain, sweat, or submersion in cold water. (cdc.gov)
  • However, the following is a list of symptoms that may occur as hypothermia progresses from mild to severe (temperatures are approximate and some symptoms may overlap). (medicinenet.com)
  • Hypothermia can occur when you are exposed to cold air, water, wind, or rain. (upmc.com)
  • Hypothermia can occur indoors, especially in babies and older or ill adults that are not dressed warmly enough. (upmc.com)
  • Subfreezing temperatures are not a requirement for hypothermia to occur. (washingtonpost.com)
  • Hypothermia in traumatic brain and spinal injuries is also in the animal investigational stages but it is showing promise in preventing the secondary effects that occur from severe trauma to the brain or spinal cord - for the same reasons cited above. (hubpages.com)
  • Although failure to produce enough body heat due to certain medical conditions (such as very low thyroid levels) can occur, by far the most common cause of hypothermia is excess heat loss. (wickedlocal.com)
  • Hypothermia related admissions occur throughout the year and peak during February. (oncologynurseadvisor.com)
  • Arizona and New Mexico), hypothermia and associated deaths also occur in states with milder climates. (cdc.gov)
  • We present evidence, based particularly on studies of Peromyscus leucopus , that neonatal rodents in deep hypothermia ( T b ≤ 7°C)-although apneic-steadily take up O 2 across the lungs and distribute it via the circulatory system. (springer.com)
  • We argue that the myocardium, respiratory rhythmogenic neurons, and possibly other vital tissues depend for their survival during deep hypothermia on this continuing O 2 supply. (springer.com)
  • In regards their steady O 2 uptake and its significance, neonatal rodents resemble rodent hibernators during deep hypothermia. (springer.com)
  • During deep hypothermia, physiologically limited mechanisms of respiratory and circulatory O 2 transport combine to provide neonate tissues with a limited rate of O 2 supply that is vitally important. (springer.com)
  • Adolph EF (1963) How do infant mammals tolerate deep hypothermia? (springer.com)
  • Hill RW (2000) Anoxia tolerance to oxygen necessity: paradigm shift in the physiology of survival of apneic deep hypothermia in neonatal rodents. (springer.com)
  • Among other autonomic dysfunctions complicating acute spinal cord injury, deep hypothermia is rare but may induce serious cardiovascular complications. (hindawi.com)
  • This case report illustrates that patients with incomplete spinal cord injury may present with delayed and deep hypothermia leading to serious cardiovascular complications. (hindawi.com)
  • Half of the elderly people who develop hypothermia die before, or soon after, being found. (hopkinsmedicine.org)
  • Mortality and the incidence of hypothermia increased with higher ISS, massive fluid resuscitation, and the presence of shock. (nih.gov)
  • Hypothermia is caused by prolonged exposures to very cold temperatures. (cdc.gov)
  • While hypothermia happens most often in very cold temperatures, even cool temperatures (above 40°F or 4°C) can be dangerous to a person who has become chilled from rain, sweat, or being in cold water for an extended period of time. (hopkinsmedicine.org)
  • You can also get hypothermia if you are exposed to indoor temperatures below 50°F (10°C) for an extended period of time. (wikihow.com)
  • It's possible to get hypothermia even when you're indoors - if it's very cold and temperatures drop to below 18°C (64.4F). As the condition can become life-threatening quickly, it's vital to be able to recognise symptoms and give treatment straight away. (metoffice.gov.uk)
  • If people don't keep themselves warm in freezing temperatures, there is a risk they could get hypothermia - especially if they're elderly, very young, or suffer from long term health conditions. (metoffice.gov.uk)
  • The winter months present a greater risk for hypothermia, but you can also be exposed to it in the spring or fall - and even in early summer months, when deep water temperatures are still much lower than surface temperatures above. (statefarm.com)
  • 0.65-0.93,pared therapeutic hypothermia to normothermia for new- respectively).borns with HIE. (slideshare.net)
  • We detected no significant harmful effects of hypothermia at 33°C [91.4°F], as compared with targeted normothermia," the authors note. (medscape.com)
  • In the European study, the median Glasgow Coma Scale score on hospital admission in both groups was 3 with an interquartile range of 3 to 5 in the group with normothermia and 3 to 4 in the group with hypothermia. (ahajournals.org)
  • 19 At 6 months there were 56 deaths in the 137 participants (41%) in the hypothermia group versus 76 of 138 (55%) in the normothermia group (RR 0.74, 95% CI 0.58 to 0.95, NNT=7). (ahajournals.org)
  • If the above symptoms are present, then it is likely the casualty is already suffering from hypothermia. (metoffice.gov.uk)
  • Giving blankets will definitely reduce the heat loss, but for a person already suffering from hypothermia, these will not be of much help. (ayushveda.com)
  • Call 911 anytime you suspect someone has hypothermia. (medlineplus.gov)
  • Call 911 or your local emergency number if you suspect someone has hypothermia. (mayoclinic.org)
  • But there are things you can do to prevent the risks associated with hypothermia - things that could save your life. (foremost.com)
  • But in fact, the sweating and work that we are doing makes hypothermia that much more of a possibility, and explains why, when we cross the finish, we are often quickly enveloped in weird silvery "space blankets" to help keep the heat in. (scientificamerican.com)
  • This revolutionary system combines the CSZ Head Wrap and Patient Vest for a non-invasive whole body hypothermia system. (bio-medicine.org)
  • Whole-body hypothermia did not significantly reduce the rate of a composite end point of death or an IQ score below 70 at 6 to 7 years of age," the researchers reported. (lww.com)
  • However, whole-body hypothermia did reduce the rate of death and did not increase the rates of low IQ score or severe disability among survivors. (lww.com)
  • Treatment of hypothermia is not always simple. (bellaonline.com)
  • There is encouraging clinical evidence from a small phase II trial that combined treatment of hypothermia with recombinant erythropoietin further reduces risk of disability but definitive studies are still needed. (springer.com)
  • The treatment of mild hypothermia involves warm drinks, warm clothing, and physical activity. (wikipedia.org)
  • Warm beverages can also be helpful, but never give a victim of hypothermia any alcoholic beverage, and never try to give an unconscious person something to drink. (hopkinsmedicine.org)
  • For mild hypothermia you want to stop heat loss by adding additional layers of warm, dry coverings. (bellaonline.com)
  • If someone is experiencing hypothermia, you want to keep them calm but alert, warm and relaxed (preferably lying down), and sheltered from the elements. (takemefishing.org)
  • If someone begins to shiver violently, stumble, or can't respond to questions, it may be hypothermia and you need to warm him or her quickly. (upmc.com)
  • If you or someone you care for has symptoms of hypothermia, give first aid to warm them up and call 911 immediately. (umm.edu)
  • The most important thing you can do for someone who has hypothermia is get them to a warm, safe place. (umm.edu)
  • The key to avoiding hypothermia is staying warm. (ctpost.com)
  • People who suffer severe head injuries appear to recover better if they are quickly chilled to a state of hypothermia, according to a study in Thursday's New England Journal of Medicine. (chicagotribune.com)
  • Someone with severe hypothermia may appear to be dead, but it's important to call emergency services right away to determine if they are in a state of hypothermia and can still be treated. (wikihow.com)
  • In his Outdoor Activity Guide to Hypothermia , Rick Curtis says "watch for the "-Umbles" - stumbles, mumbles, fumbles, and grumbles which show changes in motor coordination and levels of consciousness. (bellaonline.com)
  • Spring and fall are prime times to become a victim of hypothermia. (foremost.com)
  • Disclosed is a system and method for inducing therapeutic levels of hypothermia in a patient in the emergent care setting. (google.com)
  • Respiratory: Both tidal volumes and respiratory rate are reduced with increased levels of hypothermia. (oncologynurseadvisor.com)
Protocol-driven prevention of perioperative hypothermia in the pediatric neurosurgical population in: Journal of Neurosurgery:...
Protocol-driven prevention of perioperative hypothermia in the pediatric neurosurgical population in: Journal of Neurosurgery:... (thejns.org)
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Comparison of three different prehospital wrapping methods for preventing hypothermia - a crossover study in humans (bora.uib.no)
Yolo County baby may have died from drowning or hypothermia, autopsy shows | The Sacramento Bee
Yolo County baby may have died from drowning or hypothermia, autopsy shows | The Sacramento Bee (sacbee.com)
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Heat and Cold Related Illness - New River Gorge National River (U.S. National Park Service) (nps.gov)
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Fire Fighter Fatality Investigation Report F2006-14 | NIOSH | CDC (cdc.gov)
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Backcountry Safety - Yellowstone National Park (U.S. National Park Service) (nps.gov)
Italy cruise ship Costa Concordia: Search for missing - BBC News
Italy cruise ship Costa Concordia: Search for missing - BBC News (bbc.co.uk)
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Intravenous therapy - Wikipedia (en.wikipedia.org)
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Emergency Survival Guide - DIY Emergency Tactics (popularmechanics.com)
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Organizations by topic beginning with H: MedlinePlus (medlineplus.gov)
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Safety and Conditions | Bureau of Land Management (blm.gov)
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Cold nose: Causes, symptoms, and how to get warm (medicalnewstoday.com)
Working in cold temperatures? Your rights, the law and how to claim compensation if you've been mistreated - Mirror Online
Working in cold temperatures? Your rights, the law and how to claim compensation if you've been mistreated - Mirror Online (mirror.co.uk)
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Health in Norway - Lonely Planet (lonelyplanet.com)
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Guidelines for Perioperative Care in Elective Colonic Surgery: Enhanced Recovery After Surgery (ERAS®) Society Recommendations ...
Guidelines for Perioperative Care in Elective Colonic Surgery: Enhanced Recovery After Surgery (ERAS®) Society Recommendations ... (link.springer.com)
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Sepsis increases perioperative metastases in a murine model | SpringerLink (link.springer.com)
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Neonatal Resuscitation: 2010 American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency... (pediatrics.aappublications.org)
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Winter Weather Safety Guide | Parents (parents.com)
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The Appalachian Trail Conservancy - Hiking Basics Safety (appalachiantrail.org)
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Hypothermia | Runner's World (runnersworld.com)
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Valproic Acid Oral Solution - FDA prescribing information, side effects and uses (drugs.com)
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Depakote Capsules - FDA prescribing information, side effects and uses (drugs.com)
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Hypothermia Symptoms, Definition, Treatment & Signs (rxlist.com)
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Hypothermia: Microsoft announces quarterly dividend (hypothermia.us)
WHAT'S UP DOC? Hypothermia, 2018 Boston Marathon - Entertainment & Life - Wicked Local - Boston, MA
WHAT'S UP DOC? Hypothermia, 2018 Boston Marathon - Entertainment & Life - Wicked Local - Boston, MA (wickedlocal.com)
How to Treat Hypothermia: 15 Steps (with Pictures) - wikiHow
How to Treat Hypothermia: 15 Steps (with Pictures) - wikiHow (wikihow.com)
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RTQI | City of Boston (cityofboston.gov)
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What if I accidentally ended up locked in a walk-in freezer? | HowStuffWorks (science.howstuffworks.com)
Hypothermia Can Sometimes Save Lives | Office for Science and Society - McGill University
Hypothermia Can Sometimes Save Lives | Office for Science and Society - McGill University (mcgill.ca)
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COACT: Delayed Cath Safe in Some Non-STEMI Cardiac Arrest (medscape.com)
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