Hypolipidemic Agents: Substances that lower the levels of certain LIPIDS in the BLOOD. They are used to treat HYPERLIPIDEMIAS.Clofibrate: A fibric acid derivative used in the treatment of HYPERLIPOPROTEINEMIA TYPE III and severe HYPERTRIGLYCERIDEMIA. (From Martindale, The Extra Pharmacopoeia, 30th ed, p986)Microbodies: Electron-dense cytoplasmic particles bounded by a single membrane, such as PEROXISOMES; GLYOXYSOMES; and glycosomes.Fenofibrate: An antilipemic agent which reduces both CHOLESTEROL and TRIGLYCERIDES in the blood.Bezafibrate: An antilipemic agent that lowers CHOLESTEROL and TRIGLYCERIDES. It decreases LOW DENSITY LIPOPROTEINS and increases HIGH DENSITY LIPOPROTEINS.Clofibric Acid: An antilipemic agent that is the biologically active metabolite of CLOFIBRATE.Hyperlipidemias: Conditions with excess LIPIDS in the blood.Fibric Acids: Compounds that either share the structure of fibric acid in their molecular arrangement or are considered variants of the fibric acid structure.Nafenopin: A peroxisome proliferator that is used experimentally to promote liver tumors. It has been used as an antihyperlipoproteinemic agent.TriglyceridesCholesterol: The principal sterol of all higher animals, distributed in body tissues, especially the brain and spinal cord, and in animal fats and oils.Liver: A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.Gemfibrozil: A lipid-regulating agent that lowers elevated serum lipids primarily by decreasing serum triglycerides with a variable reduction in total cholesterol.Lipids: A generic term for fats and lipoids, the alcohol-ether-soluble constituents of protoplasm, which are insoluble in water. They comprise the fats, fatty oils, essential oils, waxes, phospholipids, glycolipids, sulfolipids, aminolipids, chromolipids (lipochromes), and fatty acids. (Grant & Hackh's Chemical Dictionary, 5th ed)Plant Extracts: Concentrated pharmaceutical preparations of plants obtained by removing active constituents with a suitable solvent, which is evaporated away, and adjusting the residue to a prescribed standard.Phytotherapy: Use of plants or herbs to treat diseases or to alleviate pain.Hibiscus: A plant genus of the family MALVACEAE. Members contain CITRIC ACID; MALATES; ANTHOCYANINS; FLAVONOIDS; GLYCOSIDES; DIETARY FIBER; and LIGNANS. Hibiscus sabdariffa is common constituent of HERBAL TEAS. Hibiscus cannabinus is a source of hemp fiber for TEXTILES.Violaceae: A plant family of the order Violales, subclass Dilleniidae, class Magnoliopsida.Inula: A plant genus of the family ASTERACEAE. Members contain INULIN, alantol, helenin, alantic acid, and acrid resin.Dilleniaceae: A plant family of the order Dilleniales, subclass Dilleniidae, class Magnoliopsida.Cinnamomum: A plant genus in the LAURACEAE family. The bark of the trees is used in FOLK MEDICINE and FLAVORING AGENTS.Peroxisome Proliferators: A class of nongenotoxic CARCINOGENS that induce the production of hepatic PEROXISOMES and induce hepatic neoplasms after long-term administration.Anticholesteremic Agents: Substances used to lower plasma CHOLESTEROL levels.Organoids: An organization of cells into an organ-like structure. Organoids can be generated in culture. They are also found in certain neoplasms.Fungal Polysaccharides: Cell wall components constituting a polysaccharide core found in fungi. They may act as antigens or structural substrates.Spirulina: A genus of filamentous CYANOBACTERIA found in most lakes and ponds. It has been used as a nutritional supplement particularly due to its high protein content.Lipid Metabolism: Physiological processes in biosynthesis (anabolism) and degradation (catabolism) of LIPIDS.Diethylhexyl Phthalate: An ester of phthalic acid. It appears as a light-colored, odorless liquid and is used as a plasticizer for many resins and elastomers.Carnitine O-Acetyltransferase: An enzyme that catalyzes the formation of O-acetylcarnitine from acetyl-CoA plus carnitine. EC 2.3.1.7.Apolipoprotein C-III: A 9-kDa protein component of VERY-LOW-DENSITY LIPOPROTEINS and CHYLOMICRON REMNANTS. Apo C-III, synthesized in the liver, is an inhibitor of LIPOPROTEIN LIPASE. Apo C-III modulates the binding of chylomicron remnants and VLDL to receptors (RECEPTORS, LDL) thus decreases the uptake of triglyceride-rich particles by the liver cells and subsequent degradation. The normal Apo C-III is glycosylated. There are several polymorphic forms with varying amounts of SIALIC ACID (Apo C-III-0, Apo C-III-1, and Apo C-III-2).Medicine, Ayurvedic: The traditional Hindu system of medicine which is based on customs, beliefs, and practices of the Hindu culture. Ayurveda means "the science of Life": veda - science, ayur - life.Hypercholesterolemia: A condition with abnormally high levels of CHOLESTEROL in the blood. It is defined as a cholesterol value exceeding the 95th percentile for the population.PPAR alpha: A nuclear transcription factor. Heterodimerization with RETINOID X RECEPTOR GAMMA is important to metabolism of LIPIDS. It is the target of FIBRATES to control HYPERLIPIDEMIAS.Pleurotus: A genus of basidiomycetous fungi, family POLYPORACEAE, order POLYPORALES, that grows on logs or tree stumps in shelflike layers. The species P. ostreatus, the oyster mushroom, is a choice edible species and is the most frequently encountered member of the genus in eastern North America. (Alexopoulos et al., Introductory Mycology, 4th ed, p531)Receptors, Cytoplasmic and Nuclear: Intracellular receptors that can be found in the cytoplasm or in the nucleus. They bind to extracellular signaling molecules that migrate through or are transported across the CELL MEMBRANE. Many members of this class of receptors occur in the cytoplasm and are transported to the CELL NUCLEUS upon ligand-binding where they signal via DNA-binding and transcription regulation. Also included in this category are receptors found on INTRACELLULAR MEMBRANES that act via mechanisms similar to CELL SURFACE RECEPTORS.Sulfides: Chemical groups containing the covalent sulfur bonds -S-. The sulfur atom can be bound to inorganic or organic moieties.Cholesterol 7-alpha-Hydroxylase: A membrane-bound cytochrome P450 enzyme that catalyzes the 7-alpha-hydroxylation of CHOLESTEROL in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP7, converts cholesterol to 7-alpha-hydroxycholesterol which is the first and rate-limiting step in the synthesis of BILE ACIDS.Apolipoprotein E2: One of three major isoforms of apolipoprotein E. In humans, Apo E2 differs from APOLIPOPROTEIN E3 at one residue 158 where arginine is replaced by cysteine (R158--C). In contrast to Apo E3, Apo E2 displays extremely low binding affinity for LDL receptors (RECEPTORS, LDL) which mediate the internalization and catabolism of lipoprotein particles in liver cells. ApoE2 allelic homozygosity is associated with HYPERLIPOPROTEINEMIA TYPE III.Apolipoproteins C: A group of apolipoproteins that can readily exchange among the various classes of lipoproteins (HDL; VLDL; CHYLOMICRONS). After lipolysis of TRIGLYCERIDES on VLDL and chylomicrons, Apo-C proteins are normally transferred to HDL. The subtypes can modulate remnant binding to receptors, LECITHIN CHOLESTEROL ACYLTRANSFERASE, or LIPOPROTEIN LIPASE.Cholesterol, LDL: Cholesterol which is contained in or bound to low density lipoproteins (LDL), including CHOLESTEROL ESTERS and free cholesterol.Niacin: A water-soluble vitamin of the B complex occurring in various animal and plant tissues. It is required by the body for the formation of coenzymes NAD and NADP. It has PELLAGRA-curative, vasodilating, and antilipemic properties.Fatty Acids: Organic, monobasic acids derived from hydrocarbons by the equivalent of oxidation of a methyl group to an alcohol, aldehyde, and then acid. Fatty acids are saturated and unsaturated (FATTY ACIDS, UNSATURATED). (Grant & Hackh's Chemical Dictionary, 5th ed)Cholesterol, Dietary: Cholesterol present in food, especially in animal products.Phthalic Acids: A group of compounds that has the general structure of a dicarboxylic acid-substituted benzene ring. The ortho-isomer is used in dye manufacture. (Dorland, 28th ed)Psyllium: Dried, ripe seeds of PLANTAGO PSYLLIUM; PLANTAGO INDICA; and PLANTAGO OVATA. Plantain seeds swell in water and are used as demulcents and bulk laxatives.Rats, Wistar: A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain.Triolein: (Z)-9-Octadecenoic acid 1,2,3-propanetriyl ester.Lipoproteins: Lipid-protein complexes involved in the transportation and metabolism of lipids in the body. They are spherical particles consisting of a hydrophobic core of TRIGLYCERIDES and CHOLESTEROL ESTERS surrounded by a layer of hydrophilic free CHOLESTEROL; PHOSPHOLIPIDS; and APOLIPOPROTEINS. Lipoproteins are classified by their varying buoyant density and sizes.Peroxisome Proliferator-Activated Receptors: TRANSCRIPTION FACTORS that are activated by ligands and heterodimerize with RETINOID X RECEPTORS and bind to peroxisome proliferator response elements in the promoter regions of target genes.Lipoproteins, VLDL: A class of lipoproteins of very light (0.93-1.006 g/ml) large size (30-80 nm) particles with a core composed mainly of TRIGLYCERIDES and a surface monolayer of PHOSPHOLIPIDS and CHOLESTEROL into which are imbedded the apolipoproteins B, E, and C. VLDL facilitates the transport of endogenously made triglycerides to extrahepatic tissues. As triglycerides and Apo C are removed, VLDL is converted to INTERMEDIATE-DENSITY LIPOPROTEINS, then to LOW-DENSITY LIPOPROTEINS from which cholesterol is delivered to the extrahepatic tissues.Corn Oil: Oil from ZEA MAYS or corn plant.Palmitic Acids: A group of 16-carbon fatty acids that contain no double bonds.Mice, Inbred ICRCatalase: An oxidoreductase that catalyzes the conversion of HYDROGEN PEROXIDE to water and oxygen. It is present in many animal cells. A deficiency of this enzyme results in ACATALASIA.Garlic: One of the Liliaceae used as a spice (SPICES) and traditional remedy. It contains alliin lyase and alliin, which is converted by alliin lyase to allicin, the pungent ingredient responsible for the aroma of fresh cut garlic.Pyrimidines: A family of 6-membered heterocyclic compounds occurring in nature in a wide variety of forms. They include several nucleic acid constituents (CYTOSINE; THYMINE; and URACIL) and form the basic structure of the barbiturates.Plant Leaves: Expanded structures, usually green, of vascular plants, characteristically consisting of a bladelike expansion attached to a stem, and functioning as the principal organ of photosynthesis and transpiration. (American Heritage Dictionary, 2d ed)Acyl-CoA Oxidase: An enzyme that catalyzes the first and rate-determining steps of peroxisomal beta-oxidation of fatty acids. It acts on COENZYME A derivatives of fatty acids with chain lengths from 8 to 18, using FLAVIN-ADENINE DINUCLEOTIDE as a cofactor.Hydroxymethylglutaryl CoA Reductases: Enzymes that catalyze the reversible reduction of alpha-carboxyl group of 3-hydroxy-3-methylglutaryl-coenzyme A to yield MEVALONIC ACID.Fish Oils: Oils high in unsaturated fats extracted from the bodies of fish or fish parts, especially the LIVER. Those from the liver are usually high in VITAMIN A. The oils are used as DIETARY SUPPLEMENTS. They are also used in soaps and detergents and as protective coatings.Diet, Fat-Restricted: A diet that contains limited amounts of fat with less than 30% of calories from all fats and less than 10% from saturated fat. Such a diet is used in control of HYPERLIPIDEMIAS. (From Bondy et al, Metabolic Control and Disease, 8th ed, pp468-70; Dorland, 27th ed)Probucol: A drug used to lower LDL and HDL cholesterol yet has little effect on serum-triglyceride or VLDL cholesterol. (From Martindale, The Extra Pharmacopoeia, 30th ed, p993).Antioxidants: Naturally occurring or synthetic substances that inhibit or retard the oxidation of a substance to which it is added. They counteract the harmful and damaging effects of oxidation in animal tissues.Hydroxymethylglutaryl-CoA Reductase Inhibitors: Compounds that inhibit HMG-CoA reductases. They have been shown to directly lower cholesterol synthesis.Hypoglycemic Agents: Substances which lower blood glucose levels.Apolipoproteins B: Major structural proteins of triacylglycerol-rich LIPOPROTEINS. There are two forms, apolipoprotein B-100 and apolipoprotein B-48, both derived from a single gene. ApoB-100 expressed in the liver is found in low-density lipoproteins (LIPOPROTEINS, LDL; LIPOPROTEINS, VLDL). ApoB-48 expressed in the intestine is found in CHYLOMICRONS. They are important in the biosynthesis, transport, and metabolism of triacylglycerol-rich lipoproteins. Plasma Apo-B levels are high in atherosclerotic patients but non-detectable in ABETALIPOPROTEINEMIA.Organ Size: The measurement of an organ in volume, mass, or heaviness.Cholesterol, HDL: Cholesterol which is contained in or bound to high-density lipoproteins (HDL), including CHOLESTEROL ESTERS and free cholesterol.Dietary Fats: Fats present in food, especially in animal products such as meat, meat products, butter, ghee. They are present in lower amounts in nuts, seeds, and avocados.Sterol O-Acyltransferase: An enzyme that catalyzes the formation of cholesterol esters by the direct transfer of the fatty acid group from a fatty acyl CoA derivative. This enzyme has been found in the adrenal gland, gonads, liver, intestinal mucosa, and aorta of many mammalian species. EC 2.3.1.26.Hepatocytes: The main structural component of the LIVER. They are specialized EPITHELIAL CELLS that are organized into interconnected plates called lobules.Lipoproteins, LDL: A class of lipoproteins of small size (18-25 nm) and light (1.019-1.063 g/ml) particles with a core composed mainly of CHOLESTEROL ESTERS and smaller amounts of TRIGLYCERIDES. The surface monolayer consists mostly of PHOSPHOLIPIDS, a single copy of APOLIPOPROTEIN B-100, and free cholesterol molecules. The main LDL function is to transport cholesterol and cholesterol esters to extrahepatic tissues.Cholesterol, VLDL: Cholesterol which is contained in or bound to very low density lipoproteins (VLDL). High circulating levels of VLDL cholesterol are found in HYPERLIPOPROTEINEMIA TYPE IIB. The cholesterol on the VLDL is eventually delivered by LOW-DENSITY LIPOPROTEINS to the tissues after the catabolism of VLDL to INTERMEDIATE-DENSITY LIPOPROTEINS, then to LDL.Heptanoic Acids: 7-carbon saturated monocarboxylic acids.Diabetes Mellitus, Experimental: Diabetes mellitus induced experimentally by administration of various diabetogenic agents or by PANCREATECTOMY.Body Weight: The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.Blood Glucose: Glucose in blood.Transcription Factors: Endogenous substances, usually proteins, which are effective in the initiation, stimulation, or termination of the genetic transcription process.Liver Neoplasms, Experimental: Experimentally induced tumors of the LIVER.Dyslipidemias: Abnormalities in the serum levels of LIPIDS, including overproduction or deficiency. Abnormal serum lipid profiles may include high total CHOLESTEROL, high TRIGLYCERIDES, low HIGH DENSITY LIPOPROTEIN CHOLESTEROL, and elevated LOW DENSITY LIPOPROTEIN CHOLESTEROL.Dose-Response Relationship, Drug: The relationship between the dose of an administered drug and the response of the organism to the drug.Receptors, LDL: Receptors on the plasma membrane of nonhepatic cells that specifically bind LDL. The receptors are localized in specialized regions called coated pits. Hypercholesteremia is caused by an allelic genetic defect of three types: 1, receptors do not bind to LDL; 2, there is reduced binding of LDL; and 3, there is normal binding but no internalization of LDL. In consequence, entry of cholesterol esters into the cell is impaired and the intracellular feedback by cholesterol on 3-hydroxy-3-methylglutaryl CoA reductase is lacking.Plant Oils: Oils derived from plants or plant products.Microsomes, Liver: Closed vesicles of fragmented endoplasmic reticulum created when liver cells or tissue are disrupted by homogenization. They may be smooth or rough.Diet, High-Fat: Consumption of excessive DIETARY FATS.Hyperlipoproteinemia Type II: A group of familial disorders characterized by elevated circulating cholesterol contained in either LOW-DENSITY LIPOPROTEINS alone or also in VERY-LOW-DENSITY LIPOPROTEINS (pre-beta lipoproteins).Bile Acids and Salts: Steroid acids and salts. The primary bile acids are derived from cholesterol in the liver and usually conjugated with glycine or taurine. The secondary bile acids are further modified by bacteria in the intestine. They play an important role in the digestion and absorption of fat. They have also been used pharmacologically, especially in the treatment of gallstones.Diet: Regular course of eating and drinking adopted by a person or animal.Dietary Fiber: The remnants of plant cell walls that are resistant to digestion by the alimentary enzymes of man. It comprises various polysaccharides and lignins.Fatty Acids, Monounsaturated: Fatty acids which are unsaturated in only one position.Mesocricetus: A genus of the family Muridae having three species. The present domesticated strains were developed from individuals brought from Syria. They are widely used in biomedical research.RNA, Messenger: RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.Lipoproteins, HDL: A class of lipoproteins of small size (4-13 nm) and dense (greater than 1.063 g/ml) particles. HDL lipoproteins, synthesized in the liver without a lipid core, accumulate cholesterol esters from peripheral tissues and transport them to the liver for re-utilization or elimination from the body (the reverse cholesterol transport). Their major protein component is APOLIPOPROTEIN A-I. HDL also shuttle APOLIPOPROTEINS C and APOLIPOPROTEINS E to and from triglyceride-rich lipoproteins during their catabolism. HDL plasma level has been inversely correlated with the risk of cardiovascular diseases.Fruit: The fleshy or dry ripened ovary of a plant, enclosing the seed or seeds.Feces: Excrement from the INTESTINES, containing unabsorbed solids, waste products, secretions, and BACTERIA of the DIGESTIVE SYSTEM.Lipid Peroxidation: Peroxidase catalyzed oxidation of lipids using hydrogen peroxide as an electron acceptor.Rats, Inbred Strains: Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations or by parent x offspring matings carried out with certain restrictions. This also includes animals with a long history of closed colony breeding.Pyrroles: Azoles of one NITROGEN and two double bonds that have aromatic chemical properties.Rats, Inbred F344Simvastatin: A derivative of LOVASTATIN and potent competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HYDROXYMETHYLGLUTARYL COA REDUCTASES), which is the rate-limiting enzyme in cholesterol biosynthesis. It may also interfere with steroid hormone production. Due to the induction of hepatic LDL RECEPTORS, it increases breakdown of LDL CHOLESTEROL.Rats, Sprague-Dawley: A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.Administration, Oral: The giving of drugs, chemicals, or other substances by mouth.Oxidation-Reduction: A chemical reaction in which an electron is transferred from one molecule to another. The electron-donating molecule is the reducing agent or reductant; the electron-accepting molecule is the oxidizing agent or oxidant. Reducing and oxidizing agents function as conjugate reductant-oxidant pairs or redox pairs (Lehninger, Principles of Biochemistry, 1982, p471).Apolipoproteins E: A class of protein components which can be found in several lipoproteins including HIGH-DENSITY LIPOPROTEINS; VERY-LOW-DENSITY LIPOPROTEINS; and CHYLOMICRONS. Synthesized in most organs, Apo E is important in the global transport of lipids and cholesterol throughout the body. Apo E is also a ligand for LDL receptors (RECEPTORS, LDL) that mediates the binding, internalization, and catabolism of lipoprotein particles in cells. There are several allelic isoforms (such as E2, E3, and E4). Deficiency or defects in Apo E are causes of HYPERLIPOPROTEINEMIA TYPE III.Time Factors: Elements of limited time intervals, contributing to particular results or situations.Eating: The consumption of edible substances.Cholesterol Esters: Fatty acid esters of cholesterol which constitute about two-thirds of the cholesterol in the plasma. The accumulation of cholesterol esters in the arterial intima is a characteristic feature of atherosclerosis.Rabbits: The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.Apolipoprotein A-I: The most abundant protein component of HIGH DENSITY LIPOPROTEINS or HDL. This protein serves as an acceptor for CHOLESTEROL released from cells thus promoting efflux of cholesterol to HDL then to the LIVER for excretion from the body (reverse cholesterol transport). It also acts as a cofactor for LECITHIN CHOLESTEROL ACYLTRANSFERASE that forms CHOLESTEROL ESTERS on the HDL particles. Mutations of this gene APOA1 cause HDL deficiency, such as in FAMILIAL ALPHA LIPOPROTEIN DEFICIENCY DISEASE and in some patients with TANGIER DISEASE.Weight Gain: Increase in BODY WEIGHT over existing weight.Gene Expression Regulation: Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.Disease Models, Animal: Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.Microscopy, Electron: Microscopy using an electron beam, instead of light, to visualize the sample, thereby allowing much greater magnification. The interactions of ELECTRONS with specimens are used to provide information about the fine structure of that specimen. In TRANSMISSION ELECTRON MICROSCOPY the reactions of the electrons that are transmitted through the specimen are imaged. In SCANNING ELECTRON MICROSCOPY an electron beam falls at a non-normal angle on the specimen and the image is derived from the reactions occurring above the plane of the specimen.Insulin: A 51-amino acid pancreatic hormone that plays a major role in the regulation of glucose metabolism, directly by suppressing endogenous glucose production (GLYCOGENOLYSIS; GLUCONEOGENESIS) and indirectly by suppressing GLUCAGON secretion and LIPOLYSIS. Native insulin is a globular protein comprised of a zinc-coordinated hexamer. Each insulin monomer containing two chains, A (21 residues) and B (30 residues), linked by two disulfide bonds. Insulin is used as a drug to control insulin-dependent diabetes mellitus (DIABETES MELLITUS, TYPE 1).Cricetinae: A subfamily in the family MURIDAE, comprising the hamsters. Four of the more common genera are Cricetus, CRICETULUS; MESOCRICETUS; and PHODOPUS.Adipose Tissue: Specialized connective tissue composed of fat cells (ADIPOCYTES). It is the site of stored FATS, usually in the form of TRIGLYCERIDES. In mammals, there are two types of adipose tissue, the WHITE FAT and the BROWN FAT. Their relative distributions vary in different species with most adipose tissue being white.Obesity: A status with BODY WEIGHT that is grossly above the acceptable or desirable weight, usually due to accumulation of excess FATS in the body. The standards may vary with age, sex, genetic or cultural background. In the BODY MASS INDEX, a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese (MORBID OBESITY).Ligands: A molecule that binds to another molecule, used especially to refer to a small molecule that binds specifically to a larger molecule, e.g., an antigen binding to an antibody, a hormone or neurotransmitter binding to a receptor, or a substrate or allosteric effector binding to an enzyme. Ligands are also molecules that donate or accept a pair of electrons to form a coordinate covalent bond with the central metal atom of a coordination complex. (From Dorland, 27th ed)Cells, Cultured: Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.Cell Line: Established cell cultures that have the potential to propagate indefinitely.
"Hypolipidemic Agents". Springer Science & Business Media. Retrieved 3 October 2017 - via Google Books. CS1 maint: Multiple ...
Indira, M.; Kurup, P.A. (September 2013). "Black Gram: A Hypolipidemic Pulse" (PDF). Natural Product Radiance. 2 (5). Vijaya J ...
Hypolipidemic agents, or antihyperlipidemic agents, are a diverse group of pharmaceuticals that are used in the treatment of ... There are several classes of hypolipidemic drugs. They may differ in both their impact on the cholesterol profile and adverse ... Investigational classes of hypolipidemic agents: CETP inhibitors (cholesteryl ester transfer protein), 1 candidate is in trials ...
Pharmacological therapies include hypolipidemic agents, thrombolytics and anticoagulants. Pharmacological options for reducing ...
Rao, B. K.; Kesavulu, M. M.; Giri, R.; Appa Rao, C. (1999). "Antidiabetic and hypolipidemic effects of Momordica cymbalaria ...
Maguire JH, Murthy AR, Hall IH (1985). "Hypolipidemic activity of antiepileptic 5-phenylhydantoins in mice". Eur J Pharmacol. ... Hall IH, Patrick MA, Maguire JH (1990). "Hypolipidemic activity in rodents of phenobarbital and related derivatives". Arch ...
1997). Hypolipidemic effect of Curcuma comosa in mice. Artery 22(5): 233-241. Piyachaturawat, P., J. Charoenpiboonsin, C. ...
"Black Gram: A Hypolipidemic Pulse" (PDF). Natural Product Radiance. 2 (5). ...
... is a niacin derivative used as a hypolipidemic agent. It is an ester of pentaerythritol and nicotinic acid, has ...
Hall, Iris; Wong, Oi; Reynolds, David; Chang, J. J. (2006). "Hypolipidemic Effects of 2-Furoic Acid in Sprague-Dawley Rats". ...
... antibiotics with hypolipidemic activity". J. Antibiot. 26 (11): 676-680. doi:10.7164/antibiotics.26.676. PMID 4792115. Hijikawa ...
Burris, T. P. (2004). "The Hypolipidemic Natural Product Guggulsterone Is a Promiscuous Steroid Receptor Ligand". Molecular ...
1. Hypolipidemic and hypoglycemic agents with ability to inhibit lipid peroxidation". Journal of Medicinal Chemistry. 32 (2): ...
1976). "The Hypolipidemic Effect of Gemfibrozil (CI-719) in Laboratory Animals". Proc. roy. Soc. Med. 69 (Supplement 2): 6-9. ...
... "saponins from solanum anguivi fruits exhibit hypolipidemic potential in Rattus novergicus. Der pharmacia lettre,4:811-814". ...
... (trade name Sedalipid) is a hypolipidemic agent. Schuitemaker GE, van der Pol GA, ...
Lin, JK; Lin-Shiau, SY (February 2006). "Mechanisms of hypolipidemic and anti-obesity effects of tea and tea polyphenols". Mol ...
Hwang, J.Y.; Zhang, J.; Kang, M.J.; Lee, S.K.; Kim, H.A.; Kim, J.J.; Kim, J.I. (2007). "Hypoglycemic and hypolipidemic effects ...
"Synthesis and investigating hypoglycemic and hypolipidemic activities of some glibenclamide analogues in rats". Mini reviews in ...
"The Discovery and Development of Atorvastatin, a Potent Novel Hypolipidemic Agent" (online, print). Prog. Med. Chem. 40: 1-22. ... "The Discovery and Development of Atorvastatin, a Potent Novel Hypolipidemic Agent" (online, print). Prog. Med. Chem. 40: 1-22. ...
Naruta E, Buko V (2001). "Hypolipidemic effect of pantothenic acid derivatives in mice with hypothalamic obesity induced by ...
Kurowska EM, Manthey JA (May 2004). "Hypolipidemic effects and absorption of citrus polymethoxylated flavones in hamsters with ...
... (compactin, ML-236B) is a hypolipidemic agent that belongs to the statins class. It was isolated from the mold ...
... is a derivative of acefylline and clofibrate used as an hypolipidemic agent. FR 2393803, Tamietto, Teresio ...
Roth BD (2002). "The discovery and development of atorvastatin, a potent novel hypolipidemic agent". Progress in Medicinal ...
Hypolipidemic effects were also shown. We conclude that Spirulina maxima may be considered an alternative treatment for ...
The Hypolipidemic Activity of Metal Complexes of Amine Carboxyboranes in Rodents. Iris H. Hall,1 Bernard F. Spielvogel,2 Anup ... T. Wong, "The Hypolipidemic Activity of Metal Complexes of Amine Carboxyboranes in Rodents," Metal-Based Drugs, vol. 1, no. 4, ...
... guajava leaves and its isolated quercetin fraction have a hypolipidemic activity against carbon tetrachloride induced ... An extract of P. guajava leaves and its isolated quercetin fraction have a hypolipidemic activity against carbon tetrachloride ... Pharmacological Actions : Hepatoprotective : CK(3182) : AC(1418), Hypolipidemic : CK(3189) : AC(707) ...
... hypolipidemic explanation free. What is hypolipidemic? Meaning of hypolipidemic medical term. What does hypolipidemic mean? ... Looking for online definition of hypolipidemic in the Medical Dictionary? ... hypolipidemic. /hy·po·lip·id·emic/ (-lip″id-ēm´ik) promoting the reduction of lipid concentrations in the serum.. hypolipidemic ... hypolipidemic. hypolipidemic. [hi″po-lip″ĭ-de´mik] promoting the reduction of lipid concentrations in the serum. ...
Early effects on mitochondrial and peroxisomal beta-oxidation by the hypolipidemic 3-thia-fatty acids in rat livers.. Asiedu DK ...
Type III Hyperlipoproteinemia: Paradoxical Hypolipidemic Response to Estrogen RAMPRATAP S. KUSHWAHA, Ph.D.; WILLIAM R. HAZZARD ... Type III Hyperlipoproteinemia: Paradoxical Hypolipidemic Response to Estrogen. Ann Intern Med. 1977;87:517-525. doi: 10.7326/ ... hypolipidemic effect in six subjects (five women, one man) with type III hyperlipoproteinemia on diets both of normal and of ...
... galactagogue general-laxative grounding hair-growth-tonic hemostatic high-fiber-laxative hypertensive hypolipidemic hypotensive ...
Differential Effect of Hypolipidemic Drugs on Lipoprotein-Associated Phospholipase A2. Vasilios G. Saougos, Afroditi P. Tambaki ... Differential Effect of Hypolipidemic Drugs on Lipoprotein-Associated Phospholipase A2. Vasilios G. Saougos, Afroditi P. Tambaki ... Differential Effect of Hypolipidemic Drugs on Lipoprotein-Associated Phospholipase A2. Vasilios G. Saougos, Afroditi P. Tambaki ... Effect of Hypolipidemic Therapy on Lipoprotein Subclasses. Type IV dyslipidemic patients had higher plasma levels of VLDL- ...
Differential Effect of Hypolipidemic Drugs on Lipoprotein-Associated Phospholipase A2. Vasilios G. Saougos, Afroditi P. Tambaki ... Differential Effect of Hypolipidemic Drugs on Lipoprotein-Associated Phospholipase A2. Vasilios G. Saougos, Afroditi P. Tambaki ... Differential Effect of Hypolipidemic Drugs on Lipoprotein-Associated Phospholipase A2. Vasilios G. Saougos, Afroditi P. Tambaki ...
Hypolipidemic Effect of EPS. In this study, the hypolipidemic effects of EPS from P. geesteranus5# in streptozotocin-induced ... The aim of the present work was to evaluate the hypolipidemic activity of P. geesteranus 5# EPS in male Kunming mice. ... In particular, hypolipidemic and hpyerglycemic activities of polysaccharide from many fungi have been documented, which are ... In conclusion, P. geesteranus 5# EPS was concluded to have hypolipidemic effects in STZ-induced diabetic mice. Moreover, the ...
S. R. Sharma, S. K. Dwivedi, and D. Swarup, "Hypoglycaemic and hypolipidemic effects of Cinnamomum tamala Nees leaves," Indian ... Validation of the Antidiabetic and Hypolipidemic Effects of Clitocybe nuda by Assessment of Glucose Transporter 4 and ...
Thus, the study demonstrates that M. oleifera possesses a hypolipidemic effect.. Keywords: Moringa oleifera, HMG Co-A reductase ... Hypolipidemic and weight controlling activity of Terminalia catappa in rats on sucrose high fat diet. Indian Drugs 44: 16-20 ... Hypolipidemic effect of different extracts of Clerodendron colebrookianum Walp in normal and high-fat diet fed rats. J ... The leaves of Moringa oleifera Lam., Moringaceae, are used by the Indians in their herbal medicine as a hypolipidemic agent in ...
Hypolipidemic and Hypocholesterolemic Effect of Roselle (Hibiscus sabdariffa L.) Seeds Oil in Experimental Male Rats ...
Dietary fat content modulates the hypolipidemic effect of dietary inulin.. The hypolipidemic effect of inulin differs depending ... The hypolipidemic effect of HP-inulin differed depending on dietary fat content (5% versus 20%). Specifically, 5% inulin ... These results indicate that dietary fat content modulates the hypolipidemic effect of dietary inulin. ... Dietary fat content modulates the hypolipidemic effect of dietary inulin in rats. ...
... galactagogue general-laxative grounding hair-growth-tonic hemostatic high-fiber-laxative hypertensive hypolipidemic hypotensive ...
... highly potent and subtype-selective PPARalpha agonists with potent hypolipidemic activity. ...
... and hypolipidemic properties.Methods and Results-We show that TSA exerts antioxidant properties by delaying the onset of ... and hypolipidemic properties, potentially involving PPAR-related mechanisms. Based on these effects, it is tempting to ...
International Textbook of Diabetes Mellitus, 4th Ed., Excerpt #91: Lipid and Lipoprotein Metabolism, Hypolipidemic Agents, and ... International Textbook of Diabetes Mellitus, 4th Ed., Excerpt #91: Lipid and Lipoprotein Metabolism, Hypolipidemic Agents, and ...
Hypoglycemic and Hypolipidemic Potential of Nigella sativa L. Seed Extract in Streptozotocin (STZ)-Induced Diabetic Rats ... Hypoglycemic and Hypolipidemic Potential of Nigella sativa L. Seed Extract in Streptozotocin (STZ)-Induced Diabetic Rats. ... 2015) Hypoglycemic and Hypolipidemic Potential of Nigella sativa L. Seed Extract in Streptozotocin (STZ)-Induced Diabetic Rats ... Seed hydroalcholic Extract on hypoglycemic and hypolipidemic condition in Streptozotocin- induced diabetic rats. DM was induced ...
Global and United States Hypolipidemic drugs Depth Research Report 2017-2022 Size and Share Published in 2017-08-04 Available ... Table Global Hypolipidemic drugs Price (USD/T) by Product Others (2012-2022). Table Top Brands of Omega-3 Hypolipidemic drugs ... Table United States Hypolipidemic drugs Price (USD/T) by Product Others (2012-2022). Table Top Brands of Omega-3 Hypolipidemic ... JP Hypolipidemic drugs Business SWOT Analysis and Forecast. 8.8.4 DAIICHI SANKYO CO., LTD. JP Hypolipidemic drugs Sales Volume ...
Study of Hypolipidemic and Antioxidant Activities of Anvillea radiata Coss & Durieu in Diabetic Rats. Author(s): Morad Hebi, ... Results: AEL of A. radiate (10 mg/kg) showed a strong hypolipidemic effect both in normoglycaemic and in STZ rats after 15 days ... Results: AEL of A. radiate (10 mg/kg) showed a strong hypolipidemic effect both in normoglycaemic and in STZ rats after 15 days ... Conclusion: AEL of A. radiata (10 mg/kg) shows the potential hypolipidemic and antioxidant effects in both normal and STZ- ...
Hypoglycaemic, hypolipidemic and antioxidant properties of tulsi (Ocimum sanctum linn) on streptozotocin induced diabetes in ... Hussain, E.H.M.A., Jamil, K. & Rao, M. Hypoglycaemic, hypolipidemic and antioxidant properties of tulsi (Ocimum sanctum linn) ...
Hesperidin showed both hypoglycemic and hypolipidemic effects but did not affect bone tissue and bone metabolic makers in STZ- ...
2. Hypoglycemic, hypolipidemic and antioxidant effects of pioglitazone, insulin and synbiotic in diabetic rats - K. Kavitha, A ... Citation: Kavitha K, Reddy AG, Reddy KK, Kumar CSVS, Boobalan G, Jayakanth K (2016) Hypoglycemic, hypolipidemic and antioxidant ...
Metabolism of ethyl 2-(4-chlorophenyl)-5-(2-furyl)-oxazole-4-acetate, a new hypolipidemic agent, in the rat, rabbit, and dog. ... Metabolism of ethyl 2-(4-chlorophenyl)-5-(2-furyl)-oxazole-4-acetate, a new hypolipidemic agent, in the rat, rabbit, and dog. ... Metabolism of ethyl 2-(4-chlorophenyl)-5-(2-furyl)-oxazole-4-acetate, a new hypolipidemic agent, in the rat, rabbit, and dog. ... Metabolism of ethyl 2-(4-chlorophenyl)-5-(2-furyl)-oxazole-4-acetate, a new hypolipidemic agent, in the rat, rabbit, and dog. ...
  • Here we present a selenium-substituted fatty acid, tetradecylselenoacetic acid (TSA), which is hypothesized to have antioxidant, antiinflammatory, and hypolipidemic properties. (ovid.com)
  • Jawahir Zayani , Lovastatin: a new hypolipidemic agent: a review, Bahrain Med. (who.int)
  • Biological evaluation of (3 β )-stigmast-5-en-3-ol as potent anti-diabetic agent in regulating glucose transport using in vitro model," International Journal of Diabetes Mellitus , vol. 2, no. 2, pp. 101-109, 2010. (hindawi.com)
  • MK-0767, a novel dual PPARalpha/gamma agonist, displays robust antihyperglycemic and hypolipidemic activities. (semanticscholar.org)
  • However, the relationship between the physico-chemical properties of CS-fatty acid complexes preparations and their potential interaction with bile acids has seldom been referred, although the information is critical in the production and utilization of such hypolipidemic complexes. (thefreedictionary.com)
  • Deep sea water has hypolipidemic properties. (greenmedinfo.com)