A short thick vein formed by union of the superior mesenteric vein and the splenic vein.
Abnormal increase of resistance to blood flow within the hepatic PORTAL SYSTEM, frequently seen in LIVER CIRRHOSIS and conditions with obstruction of the PORTAL VEIN.
Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.
A system of vessels in which blood, after passing through one capillary bed, is conveyed through a second set of capillaries before it returns to the systemic circulation. It pertains especially to the hepatic portal system.
The venous pressure measured in the PORTAL VEIN.
Persistent high BLOOD PRESSURE due to KIDNEY DISEASES, such as those involving the renal parenchyma, the renal vasculature, or tumors that secrete RENIN.
Hypertension due to RENAL ARTERY OBSTRUCTION or compression.
A condition of markedly elevated BLOOD PRESSURE with DIASTOLIC PRESSURE usually greater than 120 mm Hg. Malignant hypertension is characterized by widespread vascular damage, PAPILLEDEMA, retinopathy, HYPERTENSIVE ENCEPHALOPATHY, and renal dysfunction.
The circulation of BLOOD through the LIVER.
A condition in pregnant women with elevated systolic (>140 mm Hg) and diastolic (>90 mm Hg) blood pressure on at least two occasions 6 h apart. HYPERTENSION complicates 8-10% of all pregnancies, generally after 20 weeks of gestation. Gestational hypertension can be divided into several broad categories according to the complexity and associated symptoms, such as EDEMA; PROTEINURIA; SEIZURES; abnormalities in BLOOD COAGULATION and liver functions.
Dilated blood vessels in the ESOPHAGUS or GASTRIC FUNDUS that shunt blood from the portal circulation (PORTAL SYSTEM) to the systemic venous circulation. Often they are observed in individuals with portal hypertension (HYPERTENSION, PORTAL).
Surgical venous shunt between the portal and systemic circulation to effect decompression of the portal circulation. It is performed primarily in the treatment of bleeding esophageal varices resulting from portal hypertension. Types of shunt include portacaval, splenorenal, mesocaval, splenocaval, left gastric-caval (coronary-caval), portarenal, umbilicorenal, and umbilicocaval.
An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.
A condition in which the intraocular pressure is elevated above normal and which may lead to glaucoma.
Vein formed by the union (at the hilus of the spleen) of several small veins from the stomach, pancreas, spleen and mesentery.
The short wide vessel arising from the conus arteriosus of the right ventricle and conveying unaerated blood to the lungs.
A strain of Rattus norvegicus with elevated blood pressure used as a model for studying hypertension and stroke.
A highly specific (Leu-Leu) endopeptidase that generates ANGIOTENSIN I from its precursor ANGIOTENSINOGEN, leading to a cascade of reactions which elevate BLOOD PRESSURE and increase sodium retention by the kidney in the RENIN-ANGIOTENSIN SYSTEM. The enzyme was formerly listed as EC
Liver disease in which the normal microcirculation, the gross vascular anatomy, and the hepatic architecture have been variably destroyed and altered with fibrous septa surrounding regenerated or regenerating parenchymal nodules.
Techniques for measuring blood pressure.
The movement and the forces involved in the movement of the blood through the CARDIOVASCULAR SYSTEM.
Veins which return blood from the intestines; the inferior mesenteric vein empties into the splenic vein, the superior mesenteric vein joins the splenic vein to form the portal vein.
Increased pressure within the cranial vault. This may result from several conditions, including HYDROCEPHALUS; BRAIN EDEMA; intracranial masses; severe systemic HYPERTENSION; PSEUDOTUMOR CEREBRI; and other disorders.
Examination of the portal circulation by the use of X-ray films after injection of radiopaque material.
Veins which drain the liver.
Body organ that filters blood for the secretion of URINE and that regulates ion concentrations.
A strain of Rattus norvegicus used as a normotensive control for the spontaneous hypertensive rats (SHR).
The force that opposes the flow of BLOOD through a vascular bed. It is equal to the difference in BLOOD PRESSURE across the vascular bed divided by the CARDIAC OUTPUT.
A branch of the celiac artery that distributes to the stomach, pancreas, duodenum, liver, gallbladder, and greater omentum.
A steroid metabolite that is the 11-deoxy derivative of CORTICOSTERONE and the 21-hydroxy derivative of PROGESTERONE.
The blood pressure in the VEINS. It is usually measured to assess the filling PRESSURE to the HEART VENTRICLE.
Surgical portasystemic shunt between the portal vein and inferior vena cava.
A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.
Enlargement of the RIGHT VENTRICLE of the heart. This increase in ventricular mass is often attributed to PULMONARY HYPERTENSION and is a contributor to cardiovascular morbidity and mortality.
Bleeding in any segment of the GASTROINTESTINAL TRACT from ESOPHAGUS to RECTUM.
Sodium chloride used in foods.
The total number of cases of a given disease in a specified population at a designated time. It is differentiated from INCIDENCE, which refers to the number of new cases in the population at a given time.
Method in which repeated blood pressure readings are made while the patient undergoes normal daily activities. It allows quantitative analysis of the high blood pressure load over time, can help distinguish between types of HYPERTENSION, and can assess the effectiveness of antihypertensive therapy.
A pyrrolizidine alkaloid and a toxic plant constituent that poisons livestock and humans through the ingestion of contaminated grains and other foods. The alkaloid causes pulmonary artery hypertension, right ventricular hypertrophy, and pathological changes in the pulmonary vasculature. Significant attenuation of the cardiopulmonary changes are noted after oral magnesium treatment.
The co-occurrence of pregnancy and a cardiovascular disease. The disease may precede or follow FERTILIZATION and it may or may not have a deleterious effect on the pregnant woman or FETUS.
An octapeptide that is a potent but labile vasoconstrictor. It is produced from angiotensin I after the removal of two amino acids at the C-terminal by ANGIOTENSIN CONVERTING ENZYME. The amino acid in position 5 varies in different species. To block VASOCONSTRICTION and HYPERTENSION effect of angiotensin II, patients are often treated with ACE INHIBITORS or with ANGIOTENSIN II TYPE 1 RECEPTOR BLOCKERS.
Elements of limited time intervals, contributing to particular results or situations.
A BLOOD PRESSURE regulating system of interacting components that include RENIN; ANGIOTENSINOGEN; ANGIOTENSIN CONVERTING ENZYME; ANGIOTENSIN I; ANGIOTENSIN II; and angiotensinase. Renin, an enzyme produced in the kidney, acts on angiotensinogen, an alpha-2 globulin produced by the liver, forming ANGIOTENSIN I. Angiotensin-converting enzyme, contained in the lung, acts on angiotensin I in the plasma converting it to ANGIOTENSIN II, an extremely powerful vasoconstrictor. Angiotensin II causes contraction of the arteriolar and renal VASCULAR SMOOTH MUSCLE, leading to retention of salt and water in the KIDNEY and increased arterial blood pressure. In addition, angiotensin II stimulates the release of ALDOSTERONE from the ADRENAL CORTEX, which in turn also increases salt and water retention in the kidney. Angiotensin-converting enzyme also breaks down BRADYKININ, a powerful vasodilator and component of the KALLIKREIN-KININ SYSTEM.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.
Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.
The circulation of blood through the BLOOD VESSELS supplying the abdominal VISCERA.
Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
A hormone secreted by the ADRENAL CORTEX that regulates electrolyte and water balance by increasing the renal retention of sodium and the excretion of potassium.
Drugs used to cause dilation of the blood vessels.
The number of times the HEART VENTRICLES contract per unit of time, usually per minute.
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
A condition caused by the overproduction of ALDOSTERONE. It is characterized by sodium retention and potassium excretion with resultant HYPERTENSION and HYPOKALEMIA.
Application of a ligature to tie a vessel or strangulate a part.
A condition marked by raised intracranial pressure and characterized clinically by HEADACHES; NAUSEA; PAPILLEDEMA, peripheral constriction of the visual fields, transient visual obscurations, and pulsatile TINNITUS. OBESITY is frequently associated with this condition, which primarily affects women between 20 and 44 years of age. Chronic PAPILLEDEMA may lead to optic nerve injury (see OPTIC NERVE DISEASES) and visual loss (see BLINDNESS).
Enlargement of the LEFT VENTRICLE of the heart. This increase in ventricular mass is attributed to sustained abnormal pressure or volume loads and is a contributor to cardiovascular morbidity and mortality.
Pathological conditions involving the CARDIOVASCULAR SYSTEM including the HEART; the BLOOD VESSELS; or the PERICARDIUM.
Sodium or sodium compounds used in foods or as a food. The most frequently used compounds are sodium chloride or sodium glutamate.
Condition characterized by splenomegaly, some reduction in the number of circulating blood cells in the presence of a normal or hyperactive bone marrow, and the potential for reversal by splenectomy.
Agents that promote the excretion of urine through their effects on kidney function.
Period of contraction of the HEART, especially of the HEART VENTRICLES.
Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care. (Dictionary of Health Services Management, 2d ed)
A diet which contains very little sodium chloride. It is prescribed by some for hypertension and for edematous states. (Dorland, 27th ed)
A free radical gas produced endogenously by a variety of mammalian cells, synthesized from ARGININE by NITRIC OXIDE SYNTHASE. Nitric oxide is one of the ENDOTHELIUM-DEPENDENT RELAXING FACTORS released by the vascular endothelium and mediates VASODILATION. It also inhibits platelet aggregation, induces disaggregation of aggregated platelets, and inhibits platelet adhesion to the vascular endothelium. Nitric oxide activates cytosolic GUANYLATE CYCLASE and thus elevates intracellular levels of CYCLIC GMP.
The circulation of the BLOOD through the LUNGS.
A type of surgical portasystemic shunt to reduce portal hypertension with associated complications of esophageal varices and ascites. It is performed percutaneously through the jugular vein and involves the creation of an intrahepatic shunt between the hepatic vein and portal vein. The channel is maintained by a metallic stent. The procedure can be performed in patients who have failed sclerotherapy and is an additional option to the surgical techniques of portocaval, mesocaval, and splenorenal shunts. It takes one to three hours to perform. (JAMA 1995;273(23):1824-30)
Anastomosis of splenic vein to renal vein to relieve portal hypertension.
Inbred rats derived from Sprague-Dawley rats and used for the study of salt-dependent hypertension. Salt-sensitive and salt-resistant strains have been selectively bred to show the opposite genetically determined blood pressure responses to excess sodium chloride ingestion.
A thiazide diuretic often considered the prototypical member of this class. It reduces the reabsorption of electrolytes from the renal tubules. This results in increased excretion of water and electrolytes, including sodium, potassium, chloride, and magnesium. It is used in the treatment of several disorders including edema, hypertension, diabetes insipidus, and hypoparathyroidism.
The largest branch of the celiac trunk with distribution to the spleen, pancreas, stomach and greater omentum.
Precursor of epinephrine that is secreted by the adrenal medulla and is a widespread central and autonomic neurotransmitter. Norepinephrine is the principal transmitter of most postganglionic sympathetic fibers and of the diffuse projection system in the brain arising from the locus ceruleus. It is also found in plants and is used pharmacologically as a sympathomimetic.
Studies in which the presence or absence of disease or other health-related variables are determined in each member of the study population or in a representative sample at one particular time. This contrasts with LONGITUDINAL STUDIES which are followed over a period of time.
A heterogeneous group of disorders characterized by HYPERGLYCEMIA and GLUCOSE INTOLERANCE.
Narrowing or occlusion of the RENAL ARTERY or arteries. It is due usually to ATHEROSCLEROSIS; FIBROMUSCULAR DYSPLASIA; THROMBOSIS; EMBOLISM, or external pressure. The reduced renal perfusion can lead to renovascular hypertension (HYPERTENSION, RENOVASCULAR).
Age as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or the effect of a circumstance. It is used with human or animal concepts but should be differentiated from AGING, a physiological process, and TIME FACTORS which refers only to the passage of time.
The nonstriated involuntary muscle tissue of blood vessels.
A syndrome of persistent PULMONARY HYPERTENSION in the newborn infant (INFANT, NEWBORN) without demonstrable HEART DISEASES. This neonatal condition can be caused by severe pulmonary vasoconstriction (reactive type), hypertrophy of pulmonary arterial muscle (hypertrophic type), or abnormally developed pulmonary arterioles (hypoplastic type). The newborn patient exhibits CYANOSIS and ACIDOSIS due to the persistence of fetal circulatory pattern of right-to-left shunting of blood through a patent ductus arteriosus (DUCTUS ARTERIOSUS, PATENT) and at times a patent foramen ovale (FORAMEN OVALE, PATENT).
A 21-amino acid peptide produced in a variety of tissues including endothelial and vascular smooth-muscle cells, neurons and astrocytes in the central nervous system, and endometrial cells. It acts as a modulator of vasomotor tone, cell proliferation, and hormone production. (N Eng J Med 1995;333(6):356-63)
Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics.
A status with BODY WEIGHT that is grossly above the acceptable or desirable weight, usually due to accumulation of excess FATS in the body. The standards may vary with age, sex, genetic or cultural background. In the BODY MASS INDEX, a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese (MORBID OBESITY).
Relatively complete absence of oxygen in one or more tissues.
A branch of the abdominal aorta which supplies the kidneys, adrenal glands and ureters.
Phenomenon where increased BLOOD PRESSURE readings taken in non-clinical settings (e.g., HOME BLOOD PRESSURE MONITORING) do not replicate in clinical settings.
A ubiquitous sodium salt that is commonly used to season food.
A class of drugs whose main indications are the treatment of hypertension and heart failure. They exert their hemodynamic effect mainly by inhibiting the renin-angiotensin system. They also modulate sympathetic nervous system activity and increase prostaglandin synthesis. They cause mainly vasodilation and mild natriuresis without affecting heart rate and contractility.
The transference of a part of or an entire liver from one human or animal to another.
Blood pressure levels that are between normotension and hypertension. Individuals with prehypertension are at a higher risk for developing cardiovascular diseases. Generally, prehypertension is defined as SYSTOLIC PRESSURE of 131-139 mm Hg and/or DIASTOLIC PRESSURE of 81-89 when the optimal is 120/80 mm Hg. For diabetics and other metabolism diseases the prehypertension is around 110-129/70-79 mm Hg.
The flow of BLOOD through or around an organ or region of the body.
An alpha-globulin of about 453 amino acids, depending on the species. It is produced by the liver and secreted into blood circulation. Angiotensinogen is the inactive precursor of natural angiotensins. Upon successive enzyme cleavages, angiotensinogen yields angiotensin I, II, and III with amino acids numbered at 10, 8, and 7, respectively.
The thoracolumbar division of the autonomic nervous system. Sympathetic preganglionic fibers originate in neurons of the intermediolateral column of the spinal cord and project to the paravertebral and prevertebral ganglia, which in turn project to target organs. The sympathetic nervous system mediates the body's response to stressful situations, i.e., the fight or flight reactions. It often acts reciprocally to the parasympathetic system.
Accumulation or retention of free fluid within the peritoneal cavity.
The physiological narrowing of BLOOD VESSELS by contraction of the VASCULAR SMOOTH MUSCLE.
Drugs used to cause constriction of the blood vessels.
A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain.
The formation or presence of a blood clot (THROMBUS) within a vein.
The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.
Surgical procedure involving either partial or entire removal of the spleen.
Individuals whose ancestral origins are in the continent of Africa.
The physiological widening of BLOOD VESSELS by relaxing the underlying VASCULAR SMOOTH MUSCLE.
Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.
A complication of PREGNANCY, characterized by a complex of symptoms including maternal HYPERTENSION and PROTEINURIA with or without pathological EDEMA. Symptoms may range between mild and severe. Pre-eclampsia usually occurs after the 20th week of gestation, but may develop before this time in the presence of trophoblastic disease.
The number of new cases of a given disease during a given period in a specified population. It also is used for the rate at which new events occur in a defined population. It is differentiated from PREVALENCE, which refers to all cases, new or old, in the population at a given time.
A member of the alkali group of metals. It has the atomic symbol Na, atomic number 11, and atomic weight 23.
A prostaglandin that is a powerful vasodilator and inhibits platelet aggregation. It is biosynthesized enzymatically from PROSTAGLANDIN ENDOPEROXIDES in human vascular tissue. The sodium salt has been also used to treat primary pulmonary hypertension (HYPERTENSION, PULMONARY).
Levels within a diagnostic group which are established by various measurement criteria applied to the seriousness of a patient's disorder.
The qualitative or quantitative estimation of the likelihood of adverse effects that may result from exposure to specified health hazards or from the absence of beneficial influences. (Last, Dictionary of Epidemiology, 1988)
Single pavement layer of cells which line the luminal surface of the entire vascular system and regulate the transport of macromolecules and blood components.
The presence of albumin in the urine, an indicator of KIDNEY DISEASES.
The measurement of an organ in volume, mass, or heaviness.
Maleness or femaleness as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or effect of a circumstance. It is used with human or animal concepts but should be differentiated from SEX CHARACTERISTICS, anatomical or physiological manifestations of sex, and from SEX DISTRIBUTION, the number of males and females in given circumstances.
The blood pressure in the ARTERIES. It is commonly measured with a SPHYGMOMANOMETER on the upper arm which represents the arterial pressure in the BRACHIAL ARTERY.
Pathological processes of the KIDNEY or its component tissues.
Pathological processes of the LIVER.
Pathological processes involving any of the BLOOD VESSELS in the cardiac or peripheral circulation. They include diseases of ARTERIES; VEINS; and rest of the vasculature system in the body.
The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
A potent and specific inhibitor of PEPTIDYL-DIPEPTIDASE A. It blocks the conversion of ANGIOTENSIN I to ANGIOTENSIN II, a vasoconstrictor and important regulator of arterial blood pressure. Captopril acts to suppress the RENIN-ANGIOTENSIN SYSTEM and inhibits pressure responses to exogenous angiotensin.
Agents that inhibit SODIUM CHLORIDE SYMPORTERS. They act as DIURETICS. Excess use is associated with HYPOKALEMIA.
The vessels carrying blood away from the heart.
Experimentally induced chronic injuries to the parenchymal cells in the liver to achieve a model for LIVER CIRRHOSIS.
Agents that antagonize ANGIOTENSIN II TYPE 1 RECEPTOR. Included are ANGIOTENSIN II analogs such as SARALASIN and biphenylimidazoles such as LOSARTAN. Some are used as ANTIHYPERTENSIVE AGENTS.
A subtype of bone morphogenetic protein receptors with low affinity for BONE MORPHOGENETIC PROTEINS. They are constitutively active PROTEIN-SERINE-THREONINE KINASES that can interact with and phosphorylate TYPE I BONE MORPHOGENETIC PROTEIN RECEPTORS.
An indicator of body density as determined by the relationship of BODY WEIGHT to BODY HEIGHT. BMI=weight (kg)/height squared (m2). BMI correlates with body fat (ADIPOSE TISSUE). Their relationship varies with age and gender. For adults, BMI falls into these categories: below 18.5 (underweight); 18.5-24.9 (normal); 25.0-29.9 (overweight); 30.0 and above (obese). (National Center for Health Statistics, Centers for Disease Control and Prevention)
The main trunk of the systemic arteries.
The circulation of the BLOOD through the vessels of the KIDNEY.
Tomography using x-ray transmission and a computer algorithm to reconstruct the image.
Post-systolic relaxation of the HEART, especially the HEART VENTRICLES.
Ultrasonic recording of the size, motion, and composition of the heart and surrounding tissues. The standard approach is transthoracic.
A long-acting dihydropyridine calcium channel blocker. It is effective in the treatment of ANGINA PECTORIS and HYPERTENSION.
Drugs that bind to but do not activate beta-adrenergic receptors thereby blocking the actions of beta-adrenergic agonists. Adrenergic beta-antagonists are used for treatment of hypertension, cardiac arrhythmias, angina pectoris, glaucoma, migraine headaches, and anxiety.
The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)
Conditions or pathological processes associated with the disease of diabetes mellitus. Due to the impaired control of BLOOD GLUCOSE level in diabetic patients, pathological processes develop in numerous tissues and organs including the EYE, the KIDNEY, the BLOOD VESSELS, and the NERVE TISSUE.
Enlargement of the spleen.
Liver diseases caused by infections with PARASITES, such as tapeworms (CESTODA) and flukes (TREMATODA).
A cardioselective beta-1 adrenergic blocker possessing properties and potency similar to PROPRANOLOL, but without a negative inotropic effect.
A class of drugs that act by selective inhibition of calcium influx through cellular membranes.
A statistical technique that isolates and assesses the contributions of categorical independent variables to variation in the mean of a continuous dependent variable.
Excision of all or part of the liver. (Dorland, 28th ed)
A syndrome characterized by central nervous system dysfunction in association with LIVER FAILURE, including portal-systemic shunts. Clinical features include lethargy and CONFUSION (frequently progressing to COMA); ASTERIXIS; NYSTAGMUS, PATHOLOGIC; brisk oculovestibular reflexes; decorticate and decerebrate posturing; MUSCLE SPASTICITY; and bilateral extensor plantar reflexes (see REFLEX, BABINSKI). ELECTROENCEPHALOGRAPHY may demonstrate triphasic waves. (From Adams et al., Principles of Neurology, 6th ed, pp1117-20; Plum & Posner, Diagnosis of Stupor and Coma, 3rd ed, p222-5)
A set of techniques used when variation in several variables has to be studied simultaneously. In statistics, multivariate analysis is interpreted as any analytic method that allows simultaneous study of two or more dependent variables.
An antagonist of ANGIOTENSIN TYPE 1 RECEPTOR with antihypertensive activity due to the reduced pressor effect of ANGIOTENSIN II.
An eicosanoid, derived from the cyclooxygenase pathway of arachidonic acid metabolism. It is a stable and synthetic analog of EPOPROSTENOL, but with a longer half-life than the parent compound. Its actions are similar to prostacyclin. Iloprost produces vasodilation and inhibits platelet aggregation.
Excision of kidney.
Short thick veins which return blood from the kidneys to the vena cava.
The range or frequency distribution of a measurement in a population (of organisms, organs or things) that has not been selected for the presence of disease or abnormality.
Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations or by parent x offspring matings carried out with certain restrictions. This also includes animals with a long history of closed colony breeding.
Radiography of blood vessels after injection of a contrast medium.
Statistical models which describe the relationship between a qualitative dependent variable (that is, one which can take only certain discrete values, such as the presence or absence of a disease) and an independent variable. A common application is in epidemiology for estimating an individual's risk (probability of a disease) as a function of a given risk factor.
Cell surface proteins that bind ENDOTHELINS with high affinity and trigger intracellular changes which influence the behavior of cells.
Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood.
A direct-acting vasodilator that is used as an antihypertensive agent.
A value equal to the total volume flow divided by the cross-sectional area of the vascular bed.
The volume of water filtered out of plasma through glomerular capillary walls into Bowman's capsules per unit of time. It is considered to be equivalent to INULIN clearance.
A subclass of DIABETES MELLITUS that is not INSULIN-responsive or dependent (NIDDM). It is characterized initially by INSULIN RESISTANCE and HYPERINSULINEMIA; and eventually by GLUCOSE INTOLERANCE; HYPERGLYCEMIA; and overt diabetes. Type II diabetes mellitus is no longer considered a disease exclusively found in adults. Patients seldom develop KETOSIS but often exhibit OBESITY.
A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.
The presence of co-existing or additional diseases with reference to an initial diagnosis or with reference to the index condition that is the subject of study. Comorbidity may affect the ability of affected individuals to function and also their survival; it may be used as a prognostic indicator for length of hospital stay, cost factors, and outcome or survival.
The presence of proteins in the urine, an indicator of KIDNEY DISEASES.
An angiotensin receptor subtype that is expressed at high levels in a variety of adult tissues including the CARDIOVASCULAR SYSTEM, the KIDNEY, the ENDOCRINE SYSTEM and the NERVOUS SYSTEM. Activation of the type 1 angiotensin receptor causes VASOCONSTRICTION and sodium retention.
A benzenesulfonamide-phthalimidine that tautomerizes to a BENZOPHENONES form. It is considered a thiazide-like diuretic.
The relationship between the dose of an administered drug and the response of the organism to the drug.
Tumors or cancer of the LIVER.
An NADPH-dependent enzyme that catalyzes the conversion of L-ARGININE and OXYGEN to produce CITRULLINE and NITRIC OXIDE.
The blood pressure as recorded after wedging a CATHETER in a small PULMONARY ARTERY; believed to reflect the PRESSURE in the pulmonary CAPILLARIES.
Enlargement of the HEART, usually indicated by a cardiothoracic ratio above 0.50. Heart enlargement may involve the right, the left, or both HEART VENTRICLES or HEART ATRIA. Cardiomegaly is a nonspecific symptom seen in patients with chronic systolic heart failure (HEART FAILURE) or several forms of CARDIOMYOPATHIES.
The end-stage of CHRONIC RENAL INSUFFICIENCY. It is characterized by the severe irreversible kidney damage (as measured by the level of PROTEINURIA) and the reduction in GLOMERULAR FILTRATION RATE to less than 15 ml per min (Kidney Foundation: Kidney Disease Outcome Quality Initiative, 2002). These patients generally require HEMODIALYSIS or KIDNEY TRANSPLANTATION.
A peptidyl-dipeptidase that catalyzes the release of a C-terminal dipeptide, -Xaa-*-Xbb-Xcc, when neither Xaa nor Xbb is Pro. It is a Cl(-)-dependent, zinc glycoprotein that is generally membrane-bound and active at neutral pH. It may also have endopeptidase activity on some substrates. (From Enzyme Nomenclature, 1992) EC
A CALCIUM-dependent, constitutively-expressed form of nitric oxide synthase found primarily in ENDOTHELIAL CELLS.
A series of heterocyclic compounds that are variously substituted in nature and are known also as purine bases. They include ADENINE and GUANINE, constituents of nucleic acids, as well as many alkaloids such as CAFFEINE and THEOPHYLLINE. Uric acid is the metabolic end product of purine metabolism.
Therapy with two or more separate preparations given for a combined effect.
The venous trunk which receives blood from the lower extremities and from the pelvic and abdominal organs.
In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test.
Procedures for finding the mathematical function which best describes the relationship between a dependent variable and one or more independent variables. In linear regression (see LINEAR MODELS) the relationship is constrained to be a straight line and LEAST-SQUARES ANALYSIS is used to determine the best fit. In logistic regression (see LOGISTIC MODELS) the dependent variable is qualitative rather than continuously variable and LIKELIHOOD FUNCTIONS are used to find the best relationship. In multiple regression, the dependent variable is considered to depend on more than a single independent variable.
Glucose in blood.
The volume of BLOOD passing through the HEART per unit of time. It is usually expressed as liters (volume) per minute so as not to be confused with STROKE VOLUME (volume per beat).
Arteries which arise from the abdominal aorta and distribute to most of the intestines.
A subtype of endothelin receptor found predominantly in the VASCULAR SMOOTH MUSCLE. It has a high affinity for ENDOTHELIN-1 and ENDOTHELIN-2.
The hemodynamic and electrophysiological action of the right HEART VENTRICLE.
A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827)
Pathologic processes that affect patients after a surgical procedure. They may or may not be related to the disease for which the surgery was done, and they may or may not be direct results of the surgery.
FIBROSIS of the hepatic parenchyma due to chronic excess ALCOHOL DRINKING.
A process involving chance used in therapeutic trials or other research endeavor for allocating experimental subjects, human or animal, between treatment and control groups, or among treatment groups. It may also apply to experiments on inanimate objects.
Individuals whose ancestral origins are in the continent of Europe.
Sodium excretion by URINATION.
The ratio of two odds. The exposure-odds ratio for case control data is the ratio of the odds in favor of exposure among cases to the odds in favor of exposure among noncases. The disease-odds ratio for a cohort or cross section is the ratio of the odds in favor of disease among the exposed to the odds in favor of disease among the unexposed. The prevalence-odds ratio refers to an odds ratio derived cross-sectionally from studies of prevalent cases.
The worsening of a disease over time. This concept is most often used for chronic and incurable diseases where the stage of the disease is an important determinant of therapy and prognosis.
A condition in which the hepatic venous outflow is obstructed anywhere from the small HEPATIC VEINS to the junction of the INFERIOR VENA CAVA and the RIGHT ATRIUM. Usually the blockage is extrahepatic and caused by blood clots (THROMBUS) or fibrous webs. Parenchymal FIBROSIS is uncommon.
Compounds that specifically inhibit PHOSPHODIESTERASE 5.
A non-selective inhibitor of nitric oxide synthase. It has been used experimentally to induce hypertension.
The removal or interruption of some part of the sympathetic nervous system for therapeutic or research purposes.
A method of studying a drug or procedure in which both the subjects and investigators are kept unaware of who is actually getting which specific treatment.
A group of CORTICOSTEROIDS primarily associated with water and electrolyte balance. This is accomplished through the effect on ION TRANSPORT in renal tubules, resulting in retention of sodium and loss of potassium. Mineralocorticoid secretion is itself regulated by PLASMA VOLUME, serum potassium, and ANGIOTENSIN II.
A condition in which the RIGHT VENTRICLE of the heart was functionally impaired. This condition usually leads to HEART FAILURE or MYOCARDIAL INFARCTION, and other cardiovascular complications. Diagnosis is made by measuring the diminished ejection fraction and a depressed level of motility of the right ventricular wall.
Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.

Factors mediating the hemodynamic effects of tumor necrosis factor-alpha in portal hypertensive rats. (1/1000)

Nitric oxide, prostacyclin, and glucagon have been implicated in promoting the hyperdynamic circulatory state of portal hypertension. Recent evidence also indicates that increased tumor necrosis factor-alpha (TNF-alpha) production is involved in the pathogenesis of this hemodynamic abnormality. This study was aimed at investigating in rats with portal vein stenosis (PVS) the effects on splanchnic hemodynamics of blocking circulating TNF-alpha and the factors mediating the vascular action of this cytokine in this setting. Anti-TNF-alpha polyclonal antibodies or placebo was injected into rats (n = 96) before and 4 days after PVS (short-term inhibition) and at 24 h and 4, 7, 10 days after PVS (long-term inhibition). Short-term TNF-alpha inhibition reduced portal venous inflow and cardiac index and increased splanchnic and systemic resistance. Portal pressure was unchanged, but portal-systemic shunting was decreased. After long-term TNF-alpha inhibition, portal venous inflow and portal pressure were unchanged, but arterial pressure and systemic resistance rose significantly. Anti-TNF-alpha PVS rats exhibited lower increments of systemic resistance after Nomega-nitro-L-arginine methyl ester and indomethacin administration and lower serum levels of TNF-alpha, nitrates-nitrites, and 6-keto-PGF1alpha, both over the short and the long term. Serum glucagon levels rose after long-term inhibition. In conclusion, the specific role played by TNF-alpha in the development of the hyperdynamic state of portal hypertension appears to be mainly mediated through an increased release of nitric oxide and prostacyclin. Maintenance of the splanchnic hyperemia after long-term TNF-alpha inhibition could be due to a compensatory release of glucagon.  (+info)

Comparison of endoscopic ligation and propranolol for the primary prevention of variceal bleeding. (2/1000)

BACKGROUND AND METHODS: We compared propranolol therapy and endoscopic ligation for the primary prevention of bleeding from esophageal varices. This prospective, controlled trial included consecutive eligible patients who had large varices (>5 mm in diameter) that were at high risk for bleeding. The patients were assigned to either propranolol therapy, at a dose sufficient to decrease the base-line heart rate by 25 percent, or variceal ligation, to be performed weekly until the varices were obliterated or so reduced in size that it was not possible to continue treatment. RESULTS: Of the 89 patients, 82 of whom had cirrhosis of the liver, 44 received propranolol and 45 underwent variceal ligation. The mean (+/-SD) duration of follow-up in each group was 14+/-9 and 13+/-10 months, respectively. The mean time required to achieve an adequate reduction in the heart rate was 2.5+/-1.7 days; the mean number of sessions needed to complete variceal ligation was 3.2+/-1.1. After 18 months, the actuarial probability of bleeding was 43 percent in the propranolol group and 15 percent in the ligation group (P=0.04). Twelve patients in the propranolol group and four in the ligation group had bleeding. Three of the four in the ligation group had bleeding before their varices had been obliterated. Nine patients in the ligation group had recurrent varices, a mean of 3.7 months after the initial treatment. Five patients in each group died; bleeding from the varices was the cause of death of four patients in the propranolol group and of three in the ligation group. There were no serious complications of variceal ligation; in the propranolol group, treatment was stopped in two patients because of side effects. CONCLUSIONS: In patients with high-risk esophageal varices, endoscopic ligation of the varices is safe and more effective than propranolol for the primary prevention of variceal bleeding.  (+info)

NO overproduction by eNOS precedes hyperdynamic splanchnic circulation in portal hypertensive rats. (3/1000)

Chronic high blood flow and the hyperdynamic circulatory syndrome in portal hypertension are associated with endothelial constitutive nitric oxide (NO) synthase (eNOS) upregulation and increased NO release. In portal vein-ligated (PVL) rats the splanchnic circulation is not yet hyperdynamic on day 3 postoperatively. In vitro perfused superior mesenteric arteries (SMAs) of day 3 PVL and sham rats were challenged with increasing flow rates or the alpha-adrenoreceptor agonist methoxamine (30 and 100 microM) before and after incubation with the NO inhibitor, Nomega-nitro-L-arginine (L-NNA, 10(-4) M). Perfusate NO metabolite (NOx) concentrations were measured by chemiluminescence. PVL rats expressed a significant hyporesponsiveness to increases in flow rate or methoxamine that was overcome by incubation with L-NNA. The PVL vasculature showed significantly higher slopes of NOx production vs. flow-induced shear stress, higher increases in perfusate NOx concentration in response to methoxamine, and higher eNOS protein levels (Western blot) compared with sham rats. In conclusion, eNOS-upregulation and increased NO release by the SMA endothelium occur before the development of the hyperdynamic splanchnic circulation, suggesting a primary role of NO in the pathogenesis of arterial vasodilatation.  (+info)

Gastric antral vascular ectasia in cirrhotic patients: absence of relation with portal hypertension. (4/1000)

BACKGROUND: Portal hypertensive gastropathy and gastric antral vascular ectasia (GAVE) are increasingly recognised as separate entities. The pathogenic role of portal hypertension for the development of GAVE is still controversial. AIMS: To evaluate the effects of portal decompression on chronic bleeding related to GAVE in cirrhotic patients. METHODS: Eight patients with cirrhosis and chronic blood loss related to GAVE were included. GAVE was defined endoscopically and histologically. RESULTS: All patients had severe portal hypertension (mean portocaval gradient (PCG) 26 mm Hg) and chronic low grade bleeding. Seven patients underwent transjugular intrahepatic portosystemic shunt (TIPS) and one had an end to side portacaval shunt. Rebleeding occurred in seven patients. In these, TIPS was found to be occluded after 15 days in one patient; in the other six, the shunt was patent and the PCG was below 12 mm Hg in five. In the responder, PCG was 16 mm Hg. Antrectomy was performed in four non-responders; surgery was uneventful, and they did not rebleed after surgery, but two died 11 and 30 days postoperatively from multiorgan failure. In one patient, TIPS did not control GAVE related bleeding despite a notable decrease in PCG. This patient underwent liver transplantation 14 months after TIPS; two months after transplantation, bleeding had stopped and the endoscopic appearance of the antrum had normalised. CONCLUSIONS: Results suggest that GAVE is not directly related to portal hypertension, but is influenced by the presence of liver dysfunction. Antrectomy is a therapeutic option when chronic bleeding becomes a significant problem but carries a risk of postoperative mortality.  (+info)

Splanchnic and systemic haemodynamic response to volume changes in patients with cirrhosis and portal hypertension. (5/1000)

We investigated the haemodynamic response to volume depletion and subsequent repletion in patients with cirrhosis and portal hypertension. Twelve patients with compensated cirrhosis and portal hypertension were included in the study. The haemodynamic changes occurring after removal of approx. 15% of the blood volume, and subsequently after isovolume repletion with colloid, were assessed. Baseline haemodynamic measurements showed increased cardiac output and a systemic vascular resistance at the lower limit of normal. The hepatic venous pressure gradient (HVPG) was increased, at 18 mmHg. After depletion, arterial pressure, cardiac output and all right-heart-sided pressures decreased, and systemic vascular resistance increased. HVPG decreased to 16.0 mmHg. All the above changes were statistically significant. After blood volume restitution, the haemodynamic values returned to baseline. In particular, an increase in HVPG was shown in four out of the twelve patients (two with ascites and two without), which was small in three of them. However, HVPG remained the same as or lower than the baseline in the other eight patients. Patients with cirrhosis and portal hypertension exhibit an abnormal haemodynamic response to blood volume depletion. After volume repletion, no increase in the portal pressure was noted in this group of patients as a whole, although four out of the twelve patients did show an increase, possibly due to extensive collateral circulation.  (+info)

Cirrhosis of the liver in long-term marrow transplant survivors. (6/1000)

Patients who survive hematopoietic cell transplantation (HCT) have multiple risk factors for chronic liver disease, including hepatitis virus infection, iron overload, and chronic graft-versus-host disease (GVHD). We studied 3,721 patients who had survived 1 or more years after HCT at a single center and identified patients with histologic or clinical evidence of cirrhosis. Risk factors for the development of cirrhosis were evaluated and compared with a group of matched control subjects. Cirrhosis was identified in 31 of 3,721 patients surviving 1 or more years after HCT, 23 of 1,850 patients surviving 5 or more years, and in 19 of 860 patients surviving 10 or more years. Cumulative incidence after 10 years was estimated to be 0.6% and after 20 years was 3.8%. The median time from HCT to the diagnosis of cirrhosis was 10.1 years (range, 1.2 to 24.9 years). Twenty-three patients presented with complications of portal hypertension, and 1 presented with hepatocellular carcinoma. Thirteen patients have died from complications of liver disease, and 2 died of other causes. Three patients have undergone orthotopic liver transplantation. Hepatitis C virus infection was present in 25 of 31 (81%) of patients with cirrhosis and in 14 of 31 (45%) of controls (P =.01). Cirrhosis was attibutable to hepatitis C infection in 15 of 16 patients presenting more than 10 years after HCT. There was no difference in the prevalence of acute or chronic GVHD, duration of posttransplant immunosuppression, or posttransplant marrow iron stores between cases and controls. Cirrhosis is an important late complication of hematopoietic cell transplantation and in most cases is due to chronic hepatitis C. Long-term survivors should be evaluated for the presence of abnormal liver function and hepatitis virus infection.  (+info)

Current status of transjugular intrahepatic portosystemic shunts. (7/1000)

The use of the transjugular intrahepatic portosystemic shunt (TIPS) has emerged as an important nonoperative modality for variceal bleeding, intractable ascites, and for selected cases of hepatic venous obstruction. We believe that TIPS should be viewed as a 'bridge' to liver transplantation and should be carried out only in experienced centres. The adverse haemodynamic changes on the cardiopulmonary system after TIPS should be borne in mind. Prospective trials to evaluate the role of TIPS versus sclerotherapy in variceal bleeding will be watched with interest. There is, however, an urgent need to improve long-term results of TIPS as stent thrombosis and stenosis occur frequently. We advocate routine surveillance to detect these problems at an early stage.  (+info)

Do alterations in the rate of gastric emptying after injection sclerotherapy for oesophageal varices play any role in the development of portal hypertensive gastropathy? (8/1000)

Bleeding from portal hypertensive gastropathy (PHG) has been estimated to account for up to 30% of all upper gastrointestinal haemorrhage in patients with cirrhosis and portal hypertension. Although portal hypertension seems to be an essential prerequisite, the precise mechanisms responsible for the development of PHG are unknown. The aim of this study was to examine the role of injection sclerotherapy of oesophageal varices in the development of PHG. Gastric emptying was studied using a radionuclide test meal with the emptying characteristics of a slow liquid in 57 patients with cirrhosis and/or portal hypertension (median age 53 yrs), of whom 34 had received injection sclerotherapy for their oesophageal varices and 20 normal healthy volunteers (median age 42 yrs). As vagal damage is associated with more rapid emptying of liquids, despite hold up of solids, this technique might be expected to demonstrate such damage if gastric emptying was accelerated. The results indicated that there was no difference in the rate of gastric emptying between normal healthy volunteers and portal hypertensive patients. However, patients who had received injection sclerotherapy emptied their stomachs faster than those who had not (p < 0.05). Furthermore, the speed of gastric emptying correlated directly with the number of injections (r = 0.41; p = 0.02) and the volume of sclerosant injected (r = 0.39; p = 0.03). These observations suggest that injection sclerotherapy for oesophageal varices results in disturbances of gastric emptying that may contribute to the pathogenesis of portal hypertensive gastropathy.  (+info)

Based on this patient?s evaluation, we believe that her portal hypertension and esophageal variceal bleeding was secondary to aggressive systemic mastocytosis, likely involving the liver. Gastrointestinal involvement may be seen in up to 80% of patients with systemic mastocytosis and commonly manifests as abdominal pain, diarrhea, and nausea or vomiting.3 Bleeding from the gastrointestinal tract is typically due to peptic ulcer disease in approximately 11% of patients with systemic mastocytosis, while liver infiltration with portal hypertension is presumed to be rare. First described by Capron et al in 1978, non-cirrhotic portal hypertension as a result of systemic mastocytosis is thought to be either pre-sinusoidal or sinusoidal.4 While the exact mechanism is unknown, it is postulated that non-cirrhotic portal hypertension may develop as a result of infiltration of inflammatory mast cells within the portal vein and obstruction of the sinusoids.4 This infiltration is thought to result in ...
TY - JOUR. T1 - Prevalence of histological features of idiopathic noncirrhotic portal hypertension in general population. T2 - a retrospective study of incidental liver biopsies. AU - Zuo, Chunlai. AU - Chumbalkar, Vaibhav. AU - Ells, Peter F.. AU - Bonville, Daniel J.. AU - Lee, Hwajeong. PY - 2017/9/1. Y1 - 2017/9/1. N2 - Background: Idiopathic noncirrhotic portal hypertension (INCPH) is associated with histologic changes secondary to obliterative portal venopathy without cirrhosis. We studied the prevalence of individual histological features of INCPH in liver biopsies obtained incidentally during unrelated elective procedures and in elective liver biopsies with the diagnosis of fatty liver disease. Methods: A total of 53 incidental liver biopsies obtained intraoperatively during unrelated elective procedures and an additional 28 elective biopsies with the diagnosis of fatty liver disease without portal hypertension and cirrhosis were studied. Various histologic features of INCPH were ...
Portal hypertensive gastropathy refers to changes in the mucosa of the stomach in patients with portal hypertension; by far the most common cause of this is cirrhosis of the liver. These changes in the mucosa include friability of the mucosa and the presence of ectatic blood vessels at the surface. Patients with portal hypertensive gastropathy may experience bleeding from the stomach, which may uncommonly manifest itself in vomiting blood or melena; however, portal hypertension may cause several other more common sources of upper gastrointestinal bleeding, such as esophageal varices and gastric varices. On endoscopic evaluation of the stomach, this condition shows a characteristic mosaic or snake-skin appearance to the mucosa of the stomach. Most patients with portal hypertensive gastropathy have either a stable or improving course in the appearance of the gastropathy on endoscopy. However, according to retrospective data, roughly one in seven patients with portal hypertensive gastropathy will ...
Abstract. In this report, we present a case of isolated liver tuberculosis (TB) as a cause of non-cirrhotic portal hypertension leading to bleeding esophageal varices. Although TB has been known to cause portal hypertension in a variety of ways, this case was notable for the presence of periportal inflammation and granulomas, also seen in hepatic schistosomiasis. Herein, we discuss isolated liver TB and the differential diagnosis of non-cirrhotic portal hypertension. In endemic areas, TB should be considered in the differential diagnosis of non-cirrhotic portal hypertension.
There is no consensus about the optimal treatment of hepatocellular carcinoma (HCC) with cirrhotic portal hypertension, While this group of patients are classified as hepatectomy contraindication according to guidelines from National Comprehensive Cancer Network (NCCN) and American Association for the Study of Liver Diseases (AASLD). With improvement of surgical technique, preoperative evaluation, and perioperative management,especially the Precise Hepatectomy Technique, more and more studies confirmed the safety of surgical intervention to hepatocellular carcinoma (HCC) patients with cirrhotic portal hypertension.However, most of the previous studies were either retrospective or with small samples.. The investigators project is a prospective randomized controlled trial, planning to compare the safety, efficacy and quality of life between precise hepatectomy and combined interventional treatment on hepatocellular carcinoma (HCC) with cirrhotic portal hypertension, to make a further understanding ...
The FDA has notified healthcare professionals and patients that the use of Videx or Videx EC (didanosine, from Bristol-Myers Squibb) may cause non-cirrhotic portal hypertension, a rare but serious complication.
Didanosine linked to noncirrhotic portal hypertension. React. Wkly. 1270, 4 (2009). https://doi.org/10.2165/00128415-200912700-00008. Download ...
TY - JOUR. T1 - Liver transplantation in patients with severe portopulmonary hypertension treated with preoperative chronic intravenous epoprostenol. AU - Tan, Henkie P.. AU - Markowitz, Jay S.. AU - Montgomery, Robert A.. AU - Merritt, William T. AU - Klein, Andrew S.. AU - Thuluvath, Paul J.. AU - Poordad, F. Fred. AU - Maley, Warren R.. AU - Winters, Bradford D. AU - Akinci, Seda B.. AU - Gaine, Sean P.. PY - 2001. Y1 - 2001. N2 - Portopulmonary hypertension (PPHTN) is no longer an absolute contraindication to orthotopic liver transplantation (OLT). The pre-OLT management of patients with PPHTN requires early diagnosis and chronic therapy with intravenous epoprostenol to decrease pulmonary vascular resistance (PVR). Close follow-up is necessary to reassess pulmonary artery pressures (PAPs) and evaluate right ventricular (RV) function. This assists in the optimal timing of OLT. Successful management also necessitates reassessment of pulmonary artery hemodynamics just before OLT, with clearly ...
Four patients developed clinically important portal hypertension with histological features of idiopathic portal hypertension while they were receiving cytotoxic drugs for chronic myeloid leukaemia and Hodgkins disease. Mild sclerosis of some small portal triads was the only abnormality seen at light microscopical examination in three of the four cases. In the remaining case light microscopical findings seemed to be normal. Two cases examined by electron microscopy showed perisinusoidal fibrosis; in one case this was the only abnormality detected. There is an association between idiopathic portal hypertension and the use of chemotherapeutic agents, particularly thioguanine. Adequate histological examination of liver tissue, including electron microscopic studies, is recommended for patients who develop hepatic problems while receiving cytotoxic treatment to elucidate this problem.. ...
TY - JOUR. T1 - Pathophysiology of Portal Hypertension and Its Clinical Links. AU - Seo, Yeon Seok. AU - Shah, Vijay. PY - 2011. Y1 - 2011. N2 - Portal hypertension is a major cause of morbidity and mortality in patients with liver cirrhosis. Intrahepatic vascular resistance due to architectural distortion and intrahepatic vasoconstriction, increased portal blood flow due to splanchnic vasodilatation, and development of collateral circulation have been considered as major factors for the development of portal hypertension. Recently, sinusoidal remodeling and angiogenesis have been focused as potential etiologic factors and various researchers have tried to improve portal hypertension by modulating these new targets. This article reviews potential new treatments in the context of portal hypertension pathophysiology concepts.. AB - Portal hypertension is a major cause of morbidity and mortality in patients with liver cirrhosis. Intrahepatic vascular resistance due to architectural distortion and ...
Can Portal Hypertension Cause High Blood Pressure is a serious condition. Do you have Can Portal Hypertension Cause High Blood Pressure or are you at risk for Can Portal Hypertension Cause High Blood Pressure. But if you treat it carefully you can provent Can Portal Hypertension Cause High Blood Pressure. But bont worry about Can Portal Hypertension Cause High Blood Pressure? Youve come to the right place. This quick guide for Can Portal Hypertension Cause High Blood Pressure. These tutorial will get you started.
TY - JOUR. T1 - Two cases of esophageal cancer with portal hypertension treated with esophagectomy with venous shunt procedure. AU - Kikuchi, Kenji. AU - Okushiba, Shunichi. AU - Kitashiro, Shuuji. AU - Kawarada, You. AU - Shichinohe, Toshiaki. AU - Yamamoto, Yuhei. AU - Komatsu, Yoshito. AU - Morikawa, Toshiaki. AU - Kato, Hiroyuki. AU - Kondo, Satoshi. PY - 2006/2. Y1 - 2006/2. N2 - Some 4-6% of esophageal cancer patients have liver cirrhosis, and the incidence of complication after esophageal cancer surgery in portal hypertension due to liver cirrhosis is high. One serious complication is anastomotic leakage due to congestion of venous flow in the early postoperative course. We conducted a venous shunt in addition to reconstruction of the esophagus after esophagectomy using the gastric tube in two cases of esophageal cancer with portal hypertension to avoid congestion in the gastric tube. In Case 1, a patient with portal hypertension due to liver cirrhosis had esophageal cancer type-III. ...
ABSTRACT- To clarify the relation of pericentral fibrosis to portal hypertension, measurements of portal vascular resistance in vitro and blood pressures of several key points in hepatic vascular pathways in vivo were undertaken in rats given dimethylnitrosamine. Administration of dimethylnitrosamine induced tortuosity and narrowing of the peripheral branches of the hepatic vein due to pericentral fibrosis. No significant change was produced in the sinusoids and the portal vein branches. The portal vascular resistance was increased and the portal vein pressure was elevated markedly. The blood pressure gradient was steep in the intrahepatic vein, but not in the intrahepatic portal vein or the sinusoids, as compared to control. These data suggest that deformation of the peripheral branches of the hepatic vein due to pericentral fibrosis causes a marked increase in vascular resistance in the intrahepatic hepatic vein, i.e. postsinusoidal portal hypertension. ...
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Progesterone is very important because it functions to prepare the uterus for being pregnant and helps to keep up it. Exercising while pregnant is not only about keeping your body in higher form, though after all if you happen to feel better about your physique and the changes it is going by way of, this may most definitely have a knock-on effect to your mood, eating habits, sleep and well-being. Excessive dietary protein may cause issues in girls with underlying kidney disease. Theres supposedly something to it. As well as, The National Marketing campaign to Forestall Teen Being pregnanta nonpartisan, nonprofit group created in 1996 to help promote reducing the teen pregnancy price, set a aim of lowering teen pregnancies by one-third between 2006 and 2015. To feel more comfy at evening, some pregnant ladies may sleep in a light supportive sports bra, Moss recommended. If a gene triggers the event of testes, the embryo develops as a male. In Japan, the conventional size of a full-time period ...
Definition of portal hypertension in the Legal Dictionary - by Free online English dictionary and encyclopedia. What is portal hypertension? Meaning of portal hypertension as a legal term. What does portal hypertension mean in law?
The content of the Repository, unless otherwise specified, is protected with a Creative Commons license: Attribution-Non Commercial-No Derivatives 4.0 ...
Portal hypertension: Find the most comprehensive real-world symptom and treatment data on portal hypertension at PatientsLikeMe. 39 patients with portal hypertension experience fatigue, depressed mood, pain, anxious mood, and insomnia and use Gabapentin, Lisinopril, Nadolol, and Psychiatric evaluation to treat their portal hypertension and its symptoms.
Histopathological evaluation of the polyp showed numerous thick-walled capillaries in its subepithelial portion, and a few vascular ectasias suggestive of portal hypertensive duodenopathy. The most common manifestations of portal hypertension are esophageal and gastric varices. Gastric mucosal changes such as presence of mosaic pattern, cherry red spots and scarlatina rash on endoscopy are called as portal hypertensive gastropathy which are also not uncommon. {1} Duodenum can also be involved and apart from duodenal varices, there may be presence of erythema, scattered petechiae, friable mucosa, erosion, ulcer and edema. {2} This is known as portal duodenopathy. On histopathology, they may present as subepithelial edema and increase of diameter and wall thickness of the capillaries. {3} Polyp can also occur due to portal hypertension duodenopathy which on histology may show presence of multiple thick walled capillaries {1} as was seen in our patient. It is postulated that multiple polyps can ...
The aim of this study was to evaluate whether variant meso-Rex bypass with transposition of abdominal autogenous vein can be used as an alternative treatment modality for selected patients with symptomatic extrahepatic portal vein obstruction. This was a retrospective review of six consecutive patients who received this alternative procedure for the treatment of symptomatic portal hypertension secondary to idiopathic extrahepatic portal vein obstruction. Their clinical characteristics, operative procedures and outcomes were analyzed retrospectively. The procedure was attempted in six patients, and all had a patent shunt established by intraoperative portography at the end of the procedure; the coronary vein was used in four patients and the inferior mesenteric vein was used in two. During the median period of 23.5 months (range 10-30 months), follow-up was uneventful except one patient; reduced portal hypertension and no new episodes of gastrointestinal bleeding were observed in all patients, with the
The research, led by Dr. Mercedes Fernandez from the Institute of Biomedical Research of Barcelona Spain, examined the effects of sorafenib on rats with portal hypertension induced by partial portal vein ligation or bile duct ligation. The drug which can be taken orally, inhibits growth of new blood vessels. For those with tumors, the drug works to inhibit the the growth of new blood vessels which keep the tumor alive once it reaches a certain size. This type of drug is referred to as an angiogenesis inhibitor. Vascular formation is the trademark of portal hypertension, so to arrest this is key to slowing down the process of new formation, and decreasing portal pressure. ...
Cirrhosis is the most common cause of portal hypertension (PH) in adults, but non cirrhotic portal hypertension is frequent in children. On the basis of the site of resistance to blood flow causing hypertension, the PH can be classified as
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de Ville de Goyet, J ; Gibbs, P ; Clapuyt, Philippe ; Reding, Raymond ; Sokal, Etienne ; et. al. Original extrahilar approach for hepatic portal revascularization and relief of extrahepatic portal hypertension related to later portal vein thrombosis after pediatric liver transplantation. Long term results.. In: Transplantation, Vol. 62, no. 1, p. 71-5 (1996 ...
TY - JOUR. T1 - Portopulmonary hypertension. AU - Krowka, Michael Joseph. PY - 2012. Y1 - 2012. N2 - Portopulmonary hypertension (POPH) refers to the presence of pulmonary arterial hypertension (PAH) in patients with portal hypertension. Pulmonary hypertension in patients with liver disease or portal hypertension can be due to multiple mechanisms, including hyperdynamic (high-flow) state, increased pulmonary venous congestion, and vascular constriction or obstruction of the pulmonary arterial bed. Vascular obstruction to pulmonary arterial flow, reflected by increased pulmonary vascular resistance (PVR), is a key parameter that defines POPH. Among patients with portal hypertension, reported incidence rates of POPH range from 2 to 9%. Long-term survival in cases of POPH is poor. Favorable responses to pulmonary vasodilator/vasomodulatory therapy have been observed, but prospective, randomized trials are lacking. Severe POPH with right ventricular failure despite vasodilator therapy is associated ...
Hyposensitivity to vasopressin is a well documented phenomenon in animals with portal hypertension and patients with cirrhosis subject to haemorrhage. Haemorrhage is associated with the endogenous release of bradykinin, which may subsequently stimulate the formation of nitric oxide (NO). The present study investigated the relative contribution of NO synthase (NOS) isoforms and the role of bradykinin in the pathogenesis of splanchnic hyposensitivity to a long-acting vasopressin analogue, glypressin, in rats with portal hypertension induced by partial portal vein ligation (PVL). At 14 days after the operation, systemic and portal haemodynamics were measured in stable or bleeding PVL rats receiving an intravenous infusion of glypressin (0.07 mg/kg). In the treatment groups, NG-nitro-L-arginine methyl ester (L-NAME; a non-selective NOS inhibitor), L-canavanine (a specific inhibitor of inducible NOS) or HOE 140 (a bradykinin B2 receptor antagonist) was administered 45 min before the infusion of ...
Chronic portal vein thrombosis (PVT) is a rare disease, affecting young patients, characterized by permanent obstruction of the portal vein trunk causing portal hypertension. In 60-70% of cases it is related to high risk, moderate or mild prothrombotic risk factors.. Accordingly, there are 2 types of complications from PVT :(i) gastrointestinal haemorrhage related to portal hypertension; and (ii) recurrent thrombosis.. Recurrent thrombosis its most dreaded complication as it may lead to intestinal infarction with a related mortality of 20-60% and a high risk of intestinal insufficiency.. Gastrointestinal haemorrhage related to portal hypertension occurs in 20% patients/year. It is less frequent in patients treated with medical or endoscopic prophylaxis for variceal bleeding.. Retrospective data shows that anticoagulation does not worsen the prognosis, and may conversely improve it. Thus, in patients at risk for gastrointestinal bleeding due to portal hypertension and a mild or moderate risk of ...
TY - JOUR. T1 - Portopulmonary hypertension. T2 - An update. AU - Safdar, Zeenat. AU - Bartolome, Sonja. AU - Sussman, Norman. PY - 2012/8. Y1 - 2012/8. N2 - Portopulmonary hypertension (POPH) is a serious complication of cirrhosis that is associated with mortality beyond that predicted by the Model for End-Stage Liver Disease (MELD) score. Increased pulmonary vascular resistance (PVR) may be initiated by pulmonary vasoconstriction, altered levels of circulating mediators, or shear stress, and can eventually lead to the classic vascular remodeling (plexiform lesion) that characterizes POPH. Portal hypertension is a prerequisite for the diagnosis of POPH, although the severity of pulmonary hypertension is unrelated to the severity of portal hypertension or the nature or severity of liver disease. POPH precludes liver transplantation (LT) unless the mean pulmonary artery pressure (MPAP) can be reduced to a safe level. The concept of an acceptable pressure has changed: we now consider both MPAP and ...
Chronic liver disease and cirrhosis are the 12th leading cause of death in the United States leading to nearly 28,000 deaths per year.1 Portal hypertension in patients with cirrhosis accounts for a great deal of morbidity and mortality. It is associated with gastroesophageal varices, ascites, and variceal hemorrhage and increased risk of bacterial infection. Treatment of portal hypertension can reduce the incidence of these sequelae. The mainstay of treatment in portal hypertension is non-selective beta-blockers such as propranolol or nadolol. However, many patients are unable to tolerate the titration of these drugs to appropriate therapeutic doses or have relative contraindications to beta blocker therapy such as asthma or insulin dependent diabetes with risk of hypoglycemia.1,2 Additional treatment options either in addition to or instead of beta blockers, that act selectively on the hepatic circulation are needed. HMG-CoA reductase inhibitors have been proposed as a class of drugs that may ...
Liver cirrhosis portal hypertension patients to reduce the number of blood cells are common in clinical, and often affect the prognosis. This paper discusses cirrhotic portal hypertension patients complicated by the reason of the decrease in the number of peripheral blood cells and what is the clinical significance of these reasons so as to provide theoretical support for the choice of treatment. Splenomegaly and hypersplenism caused should be the main reason for reducing the number of blood cells, but not all, other reasons are alcohol and virus inhibition of bone marrow, liver function impairment, autoimmune damage and loss of blood, etc. If it is a function of the spleen hyperfunction caused by blood cells decreases, blood should rise to normal after splenectomy, or consider other reason or there are other reasons at the same time.
Ectopic varices (EcV) accounting for 1-5% of all varices in portal hypertension are composed of dilated portosystemic collaterals located in unusual sites instead of the most known gastroesophageal region. The difficulty in localization of bleeding is a great burden on the management of these patients. Herein, we present patients with EcV as well as with portal hypertension and recurrent intestinal bleeding. The sites of EcV were identified with computed tomographic angiography, after a series of inconclusive endoscopies, and moreover a selective celiac arteriographic examination of one of the patients. Eur J Gastroenterol Hepatol 23:620-622 (c) 2011 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins. ...
In cirrhotic livers, the balance of vasoactive substances is in favour of vasoconstrictors with relatively insufficient nitric oxide. Endothelial dysfunction has been documented in cirrhotic rat livers leading to a lower activity of endothelial nitric oxide synthase but this might not be sufficient to explain the low nitric oxide presence. We compared the amount of all nitric oxide synthase isoforms and other factors that influence nitric oxide bioavailability in livers of two portal hypertensive rat models: prehepatic portal hypertension and carbon tetrachloride induced cirrhosis, in comparison with healthy controls. Endothelial nitric oxide synthase was the solely detected isoform by Western blotting in all livers. In cirrhotic livers, the amount of endothelial nitric oxide synthase protein was lower than in healthy controls, although an overlap existed. Levels of caveolin-1 messenger RNA were within the normal range but endothelin-1 messenger RNA levels were significantly higher in cirrhotic livers
Healthcare providers treat portal hypertension in several ways. You might need to take beta blockers, or medicines that improve how your heart and blood vessels work. These medicines often also reduce the risk of bleeding from swollen veins. If you have internal bleeding because of portal hypertension, your healthcare provider might inject medicine into the vein to help stop the bleeding. Or he or she may place bands around veins to stop the bleeding. In more severe situations, your healthcare provider may treat portal hypertension with shunting. This involves putting stents in the portal vein to open it and improve blood flow. Shunting can be done with or without surgery. Surgical shunting can cause more complications than the nonsurgical method. A liver transplant may be needed.. ...
Abstract of Paper: Effect Of Angiotensin-II Receptor Blockade On Experimental Portal hypertension In Rabbits , Author: Sherif w. Mansour, Mohamed Abd El Homed and Mohamed Adel El-Sayed * , Year: 2003 , Faculty of Medicine, Benha University
See Article on [Related article:] 34. Portal hypertension (PH) is a major consequence of liver tissue fibrogenesis in chronic liver disease (CLD) [1]. During progression of CLD, the intrahepatic vasculature is remodeled and excess endogenous vasodilators are released, causing splanchnic arteriolar vasodilatation. Consequently, blood flow in the portal venous system would be increased, leading to PH. As the degree of PH becomes severe, it can result in complications such as the development of esophageal varices, variceal bleeding, ascites, spontaneous bacterial peritonitis and hepatorenal syndrome [2]. Particularly in patients with decompensated cirrhosis, PH is responsible for significant morbidity and mortality [1-4]. In this regard, precise assessment of PH allows accurate prediction of prognosis and is essential for managing CLD appropriately. Measurement of the hepatic venous pressure gradient (HVPG), the gradient between the wedged (i.e., balloon-occluded) hepatic venous pressure and the ...
TY - JOUR. T1 - Portopulmonary Hypertension. T2 - A Survey of Practice Patterns and Provider Attitudes. AU - Dubrock, Hilary M.. AU - Salgia, Reena J.. AU - Sussman, Norman L.. AU - Bartolome, Sonja D.. AU - Kadry, Zakiyah. AU - Mulligan, David C.. AU - Jenkins, Sarah. AU - Lackore, Kandace. AU - Channick, Richard N.. AU - Kawut, Steven M.. AU - Krowka, Michael J.. N1 - Publisher Copyright: © 2019 Wolters Kluwer Health. All rights reserved.. PY - 2019/6/1. Y1 - 2019/6/1. N2 - Background. The role of liver transplantation (LT) in the management of portopulmonary hypertension (POPH) is poorly understood. The aim of this study was to better understand provider attitudes and practice patterns regarding the management of patients with POPH and to assess the concordance between clinical practice and current guidelines. Methods. We performed a multicenter survey study of hepatologists and pulmonary hypertension (PH) physicians at US LT centers that performed ,50 transplants per year. Survey responses ...
Purpose: The aim of the study was to investigate the sonographic characteristics of the varices of pancreas in portal hypertension.Methods: We retrospectively reviewed the sonographic findings, case records and other diagnostic procedures of 11 patients with clinical features of portal hypertension of different etiology, all having sonographical changes suggesting presence of the pancreatic varices. Size, echogenicity, margins, location and type of vascularity were analyzed. All patients underwent subsequent upper gastrointestinal endoscopy.Results: Gray-scale sonography demonstrated either anechoic oval lesions or tortuous tubular structures located in different parts of pancreas. The vascular nature of the structures was proven by detection of blood flow on color Doppler and power Doppler sonography and categorized as venous by means of pulsed Doppler sonography. CT revealed pancreatic varices in 9 patients. Of the 11 subjects with upper gastrointestinal endoscopy performed, 9 had esophageal
To assess correlation between liver or spleen stiffness measurement by transient elastography (TE) and hepatic venous pressure gradient (HVPG) in patients with chronic liver disease as well find optimal and rule in/rule out cut-offs for prognosis of clinically significant (CSPH) and severe (SPH) portal hypertension. In this prospective study patients with different chronic liver diseases were included. TE was performed at the same day prior to HVPG measurement. HVPG was measured using catheter tip occlusion technique. Based on HVPG, patients were categorized into groups of CSPH and SPH. Cut-off values were established by applying ROC curve analysis. The study included 107 consecutive patients referred for HVPG measurement or transjugular liver biopsy. Successful spleen TE was performed in 99 of the patients. Liver and spleen TE strongly correlated with HVPG, r = 0.75 and r = 0.62, respectively. Accuracy to detect CSPH was 88.7 % for liver stiffness of 17.4 kPa and 77.7 % for spleen stiffness of 47.6 kPa
Many conditions are associated with portal hypertension, with cirrhosis being the most common cause of this disorder. Two important factors-vascular resistance and blood flow-exist in the development of portal hypertension.
TY - JOUR. T1 - Prognostic value of acute hemodynamic response to i.v. propranolol in patients with cirrhosis and portal hypertension. AU - La Mura, Vincenzo. AU - Abraldes, Juan G.. AU - Raffa, Sebastian. AU - Retto, Oswaldo. AU - Berzigotti, Annalisa. AU - García-Pagán, Juan Carlos. AU - Bosch, Jaume. PY - 2009/8. Y1 - 2009/8. N2 - Background/Aims: Cirrhotic patients chronically treated with beta-blockers who achieve a decrease of hepatic venous pressure gradient (HVPG) ≥20% from baseline or to ≤12 mmHg have a marked reduction of first bleeding or re-bleeding. However, two HVPG measurements are needed to evaluate response. This study was aimed at investigating the predictive role of acute HVPG response to i.v. propranolol for bleeding and survival. Methods: We retrospectively studied 166 cirrhotic patients with varices with HVPG response to i.v. propranolol (0.15 mg/kg). All patients subsequently received non-selective beta-blockers to prevent first bleeding (n = 78) or re-bleeding (n = ...
Portopulmonary hypertension (PPH) is defined by the coexistence of portal and pulmonary hypertension. PPH is a serious complication of liver disease, present in 0.25 to 4% of all patients suffering from cirrhosis. Once an absolute contraindication to liver transplantation, it is no longer, thanks to rapid advances in the treatment of this condition. Today, PPH is comorbid in 4-6% of those referred for a liver transplant. PPH presents roughly equally in male and female cirrhotics; 71% female in an American series and 57% male in a larger French series. Typically, patients present in their fifth decade, aged 49 +/- 11 years on average. In general, PPH is diagnosed 4-7 years after the patient is diagnosed with portal hypertension and in roughly 65% of cases, the diagnosis is actually made at the time of invasive hemodynamic monitoring following anesthesia induction prior to liver transplantation. Once patients are symptomatic, they present with right heart dysfunction secondary to pulmonary ...
Therefore, an alternative, non-invasive technique allowing clinicians to diagnose and grade PH in patients with cirrhosis and that could replace HVPG is needed. Transient elastography (TE) has been established as a non-invasive method of measuring liver stiffness due to its diagnostic accuracy in hepatic fibrosis [7]. Accumulating evidence suggests that TE adequately reflects the findings of HVPG, indicating that it is a useful modality for evaluating PH and cirrhotic complications [8-14]. However, some studies have reported conflicting results indicating TE is not sufficiently accurate to replace HVPG due to its insufficient sensitivity or specificity [15]. Hence, controversy remains regarding the usefulness of TE for assessing PH. Systematic reviews (SRs) and meta-analyses (MAs) have facilitated objective evaluation of existing evidence [16-20]. Shi et al. [21] reported the results of their MA for TE in the diagnosis of PH and esophageal varices and further studies should be performed to ...
Information on portal hypertension or high blood pressure in children including causes, symptoms and treatment from St. Louis Childrens Hospital. Learn more about blood conditions in children.
Atıf İçin Kopyala Yildirim B., Ozenirler S., Sancak A., Unal S., Demirci T., AKYOL G. JOURNAL OF GASTROINTESTINAL AND LIVER DISEASES, cilt.16, sa.4, ss.467-468, 2007 (SCI İndekslerine Giren Dergi) ...
Results: In patients with left-sided portal hypertension, gastroesophageal varices were greatly favored by two conditions: collateral pathways directed to the gastric fundus and hypertension in the left gastric vein. This last condition typically occurs when the left gastric vein inflows into an already obstructed splenic trunk, or in the case of concomitant portal hypertension. On the contrary, patients with left-sided portal hypertension and collaterals connected with the left renal or adrenal veins have minor risk of gastroesophageal varices ...
TY - JOUR. T1 - A new stent-graft for transjugular intrahepatic portosystemic shunts. AU - Rose, J. D.G.. AU - Pimpalwar, S.. AU - Jackson, R. W.. PY - 2001/1/1. Y1 - 2001/1/1. N2 - The transjugular intrahepatic portosystemic shunt (TIPSS) has become an effective method of treatment for the complications of portal hypertension, however shunt dysfunction is common. Covered stent-grafts have been tested in animal models, and customized or home-made devices have been deployed in several institutions. We report the use of a new commercially available TIPSS stent-graft in six patients undergoing primary shunting as well as two cases of revision or secondary TIPSS. The device has proved relatively easy to handle and appears to have the technical features likely to improve primary patency. Further follow-up is required to properly assess shunt patency and re-intervention rates.. AB - The transjugular intrahepatic portosystemic shunt (TIPSS) has become an effective method of treatment for the ...
Chest pain in ESRD from ADPKD has a list of differential diagnosis which includes uremic pericarditis, acute coronary artery disease, pericardial effusion and rarely pericardial cysts, among others. We present a case of pleuritic chest pain secondary to portal hypertensive gastropathy (PHG) in a 24-year old Caucasian male patient with ADPKD who was on maintenance hemodialysis for ESRD, and who previously had been misdiagnosed as acute recurrent pericarditis. The management options for PHG are briefly discussed. Finally, we propose that PHG should be kept in the differential diagnosis of chest pain, pleuritic or non-pleuritic, with or without gastrointestinal symptoms, in patients with ADPKD, with or without renal failure. Moreover, the importance of a detailed medical history in the management of these patients cannot be over emphasized.
1. The effects of propranolol on heart rate, arterial pressure, portal venous pressure and fractional hepatic blood flow were studied in rats with hepatic artery ligature or with portal vein stenosis, and in sham-operated rats. The effect of propranolol on cardiac output was also studied in normal rats.. 2. In rats with hepatic artery ligature or with portal vein stenosis, and in sham-operated rats, propranolol decreased heart rate and portal venous pressure significantly and did not alter arterial pressure. Propranolol decreased fractional hepatic blood flow significantly in rats with hepatic artery ligature, but did not change hepatic blood flow in rats with portal vein stenosis or in sham-operated rats.. 3. We conclude therefore that: (a) propranolol decreases portal venous pressure in rats; (b) this decrease in portal venous pressure results in a reduction in portal blood flow which is related, in part, to a reduction in cardiac output; (c) propranolol does not alter hepatic blood flow in ...
Saxon RR, Mendel-Hartvig J, Corless CL, Rabkin J, Uchida BT, Nishimine K, et al. Bile duct injury as a major cause of stenosis and occlusion in transjugular intrahepatic portosystemic shunts: comparative histopathologic analysis in humans and swine. J Vasc Interv Radiol 1996; 7: 487-497 ...
Portal hypertension due to intrahepatic disease or extrahepatic portal vein obstruction (EHPVO) is an important cause of upper gastrointestinal bleeding in children. About 50% of children with EHPVO present with bleeding from oesophageal varices.1-3 Improvements in the management of children with intrahepatic disease have led to increased survival, consequently contributing to the long-term burden of portal hypertension.1, 3-5. The peak age of variceal bleeding, although not clearly defined, relates to a critical point where wall tension exceeds variceal wall strength. Other determinants of a herald bleed include upper respiratory infection, fever and aspirin ingestion.6 These factors directly or indirectly increase portal venous pressure or result in fever-related tachycardia which increases cardiac output.. Since its introduction, endoscopic sclerotherapy of bleeding oesophageal varices, where variceal banding is not feasible, has remained the mainstay treatment for haemodynamically stable ...
Portal hypertension due to intrahepatic disease or extrahepatic portal vein obstruction (EHPVO) is an important cause of upper gastrointestinal bleeding in children. About 50% of children with EHPVO present with bleeding from oesophageal varices.1-3 Improvements in the management of children with intrahepatic disease have led to increased survival, consequently contributing to the long-term burden of portal hypertension.1, 3-5. The peak age of variceal bleeding, although not clearly defined, relates to a critical point where wall tension exceeds variceal wall strength. Other determinants of a herald bleed include upper respiratory infection, fever and aspirin ingestion.6 These factors directly or indirectly increase portal venous pressure or result in fever-related tachycardia which increases cardiac output.. Since its introduction, endoscopic sclerotherapy of bleeding oesophageal varices, where variceal banding is not feasible, has remained the mainstay treatment for haemodynamically stable ...
The researchers ensured that the groups were individually matched 1:1 according to age, sex, Child-Turcotte-Pugh class, and cause of cirrhosis. A stratified Cox model was used by the researchers to assess risk of hepatocelullar carcinoma development.. The investigators found that he median time of follow-up was similar in transjugular intrahepatic portosystemic shunt and non- transjugular intrahepatic portosystemic shunt cohorts; 30.3 and 31.4 months, respectively. The researchers also showed that the probability of developing hepatocelullar carcinoma at 1, 3, and 5 years was 3%, 24%, and 34% for the transjugular intrahepatic portosystemic shunt cohort and 1%, 6%, and 25%, for the control, respectively, with a hazard ratio of 1.52.. Hepatitis C virus infection and age were independent predictors of hepatocelullar carcinoma development in patients without transjugular intrahepatic portosystemic shunt. Dr Ba ares concluded, Patients with cirrhosis who are treated with transjugular intrahepatic ...
Care guide for Transjugular Intrahepatic Portosystemic Shunt (Inpatient Care). Includes: possible causes, signs and symptoms, standard treatment options and means of care and support.
Objectives The aim of this study was to prospectively evaluate effective dose (E) of operators performing transjugular intrahepatic portosystemic shunts (TIPS) in a single centre. Patients radiation...
FLAGSTAFF, Ariz. - August 1, 2017 - The GORE® VIATORR® TIPS Endoprosthesis with Controlled Expansion, a new device configuration developed by W. L. Gore & Associates, Inc. (Gore), may further reduce portal hypertension treatment complications, even compared to the GORE® VIATORR® TIPS Endoprosthesis, Gores legacy TIPS device, which has a strong history of patency and proven performance at fixed diameters. These findings were obtained from the abstract presented at The International Liver Congress 2017 in Amsterdam.1 The preliminary data at three months also confirmed that hospital readmissions from cirrhosis-related complications, including refractory ascites and sepsis, were significantly reduced using either of the GORE VIATORR TIPS Endoprosthesis products compared to bare metal stents.. Portal hypertension is an increase in the pressure in the vein that connects the digestive organs to the liver and is most often caused by cirrhosis. Transjugular intrahepatic portosystemic shunt (TIPS) ...
FLAGSTAFF, Ariz. - August 1, 2017 - The GORE® VIATORR® TIPS Endoprosthesis with Controlled Expansion, a new device configuration developed by W. L. Gore & Associates, Inc. (Gore), may further reduce portal hypertension treatment complications, even compared to the GORE® VIATORR® TIPS Endoprosthesis, Gores legacy TIPS device, which has a strong history of patency and proven performance at fixed diameters. These findings were obtained from the abstract presented at The International Liver Congress 2017 in Amsterdam.1 The preliminary data at three months also confirmed that hospital readmissions from cirrhosis-related complications, including refractory ascites and sepsis, were significantly reduced using either of the GORE VIATORR TIPS Endoprosthesis products compared to bare metal stents.. Portal hypertension is an increase in the pressure in the vein that connects the digestive organs to the liver and is most often caused by cirrhosis. Transjugular intrahepatic portosystemic shunt (TIPS) ...
TY - JOUR. T1 - Predictors of Waitlist Mortality in Portopulmonary Hypertension. AU - Dubrock, Hilary M.. AU - Goldberg, David S.. AU - Sussman, Norman L.. AU - Bartolome, Sonja D.. AU - Kadry, Zakiyah. AU - Salgia, Reena J.. AU - Mulligan, David C.. AU - Kremers, Walter K.. AU - Kawut, Steven M.. AU - Krowka, Michael J.. AU - Channick, Richard N.. N1 - Publisher Copyright: © 2017 Wolters Kluwer Health, Inc. All rights reserved.. PY - 2017/7/1. Y1 - 2017/7/1. N2 - Background The current Organ Procurement Transplantation Network policy grants Model for End-Stage Liver Disease (MELD) exception points to patients with portopulmonary hypertension (POPH), but potentially important factors, such as severity of liver disease and pulmonary hypertension, are not included in the exception score, and may affect survival. The purpose of this study was to identify significant predictors of waitlist mortality in patients with POPH. Methods We performed a retrospective cohort study of patients in the Organ ...
Portal hypertension is a clinical syndrome associated with increased blood pressure in the portal vein. Increased blood pressure may be caused by several entities, which can be divided into three groups depending on which part of the portal system was affected.. The most common cause of portal hypertension in the world is liver cirrhosis - also the most common cause of portal hypertension in the analysed group of patients (98%).. The greatest concern in the clinical course of cirrhotic patients is a bleeding from oesophageal varices. This life-threatening condition often requires immediate surgical treatment including the creation of an intrahepatic portosystemic shunt.. Patent paraumbilical vein is a common finding in patients with portal hypertension; it can be found in 6-30% of patients with cirrhosis of the liver [19]. According to Sacerdoti et al. [20] and Chen et al. [21], patent PUV is most often present in patients with alcoholic liver cirrhosis (alcoholic vs. viral - 56% vs. 29%, p = ...
Vascular diseases of the liver are a heterogeneous group of rare and if untreated fatal disorders that include portal vein thrombosis, Budd-Chiari syndrome, non-cirrhotic portal hypertension, sinusoidal obstruction syndrome, hereditary hemorrhagic teleangiectasia and others.. Current knowledge about patients suffering from these disorders is insufficient and no biological samples are available to study the mechanisms of these diseases and the effects of treatments.. Therefore, with the support of a grant from EASL, we are running this cohort study by including and following up patients on the platform redcap.ctu.unibe.ch. If you are member of VALDIG you can request a password and username (contact [email protected]) to participate to this study by including patients from your center into the database (a complete set of data) or into the registry (a limited set of data).. ...
Portal Hypertension - Networking Resource. A resource guide for those diagnosed with portal hypertension or portal vein thrombosis (PVT) - by Clint Steenson. ...
Dr. Ekong specializes in treating babies and children with a wide range of liver diseases including autoimmune diseases, biliary atresia, progressive familial intrahepatic cholestasis syndromes, other genetic/metabolic liver diseases, non-cirrhotic portal hypertension, and chronic hepatitis B and C. Pediatric Gastroenterology Transplant Surgery
These results suggest that the transjugular placement of an intrahepatic portosystemic stent is an effective and safe treatment for variceal hemorrhage in patients with portal hypertension due to cirrhosis.
Portopulmonary hypertension (POPH) is defined as pulmonary arterial hypertension (PAH) complicated by portal hypertension, with or without advanced hepatic disease. Significant percentage of patients with cirrhotic liver disease has high cardiac output and subsequently elevated pulmonary arterial pressures (PAP). However, patients with POPH develop a progressive increase in pulmonary vascular resistance (PVR), which is generally lower than that observed in other forms of PAH. The prognosis of untreated patients with POPH is very poor and the outcome of liver transplant (LT) in those patients is determined by the degree of severity of the associated pulmonary hemodynamics. In this narrative review, we describe the clinical presentation of POPH, the pathobiology, and the clinical implication of pulmonary hemodynamics. We also provide evidence-based recommendations for the diagnosic and management approaches of POPH ...
We report the case of a 37-year-old man with necrotizing pancreatitis associated with inflammatory extrahepatic portal vein stenosis and progressive ascites. Four months after the acute onset, when no signs of infection were present, portal decompression was performed to treat refractory ascites. Transjugulartranshepatic venoplasty failed to dilate the stenosis in the extrahepatic portion of the portal vein sufficiently. Therefore a Wallstent was implanted, resulting in almost normal diameter of the vessel. In follow-up imaging studies the stent and the portal vein were still patent 12 months after the intervention and total resolution of the ascites was observed. ...
Hepatic encephalopathy can arise from portal-systemic shunting in the absence of intrinsic liver disease. However, there are few descriptions of this form of encephalopathy. Portal vein thrombosis is an infrequent disease that causes portal-systemic shunting. Episodic hepatic encephalopathy has been …
Transjugular intrahepatic portosystemic shunt Intervention:Transjugular intrahepatic portosystemic shunt ICD-10 code: ICD-9 code: 39.1 Other codes: A
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Results 56 patients were included into the final analysis. In AH patients (n = 18) mean age was 48 years (30-65), mean discriminant function (DF) was 51 (24-87) and mean MELD score was 22. The 6 month mortality was 50%(9/18) with (7/9) dying within 30 days. The median HVPG (mmHg) pre-TIPS and post-TIPS were 16.5 and 6.5 respectively. In non-AH patient (n = 38) average age was 51y (25-70) mean MELD score was 14 (22-7). The mortality was 13% (5/38) at 6 months, (3/5) died by day 30. The median HVPG (mmHg) pre-TIPS and post-TIPS was 23 and 10 respectively.. ...
Images in a 59-year-old man with posthepatitic cirrhosis (Child-Pugh class C) who had undergone TIPS creation for refractory ascites; a Viatorr stent (10 mm ...
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The portal venous system is located between two capillary beds: the splanchnic capillaries and the hepatic sinusoids. Sinusoids are the specialized liver capillaries and they receive blood both from the portal vein and the hepatic artery. The branches of the portal vein and hepatic artery form the portal triad along with the interlobular bile ducts in the portal tracts. The blood flows in the sinusoid from the portal tract to the central hepatic venule. The endothelial cells that line the sinusoids are fenestrated and are devoid of a basement membrane. The sinusoids therefore have a unique structure with high permeability that allows direct contact between plasma and hepatocyte surface through the space of Disse. The sinusoidal blood drains into the tributaries of the hepatic veins through the terminal hepatic venules, and subsequently into the inferior vena cava and right atrium. Portal venous system is a low pressure system. The difference between the hepatic vein and portal vein pressure is ...
The portal venous system is located between two capillary beds: the splanchnic capillaries and the hepatic sinusoids. Sinusoids are the specialized liver capillaries and they receive blood both from the portal vein and the hepatic artery. The branches of the portal vein and hepatic artery form the portal triad along with the interlobular bile ducts in the portal tracts. The blood flows in the sinusoid from the portal tract to the central hepatic venule.. The endothelial cells that line the sinusoids are fenestrated and are devoid of a basement membrane. The sinusoids therefore have a unique structure with high permeability that allows direct contact between plasma and hepatocyte surface through the space of Disse. The sinusoidal blood drains into the tributaries of the hepatic veins through the terminal hepatic venules, and subsequently into the inferior vena cava and right atrium.. Portal venous system is a low pressure system. The difference between the hepatic vein and portal vein pressure is ...
TY - JOUR. T1 - A new mdr2-/- mouse model of sclerosing cholangitis with rapid fibrosis progression, early-onset portal hypertension, and liver cancer. AU - Ikenaga, Naoki. AU - Liu, Susan B.. AU - Sverdlov, Deanna Y.. AU - Yoshida, Shuhei. AU - Nasser, Imad. AU - Ke, Qingen. AU - Kang, Peter M.. AU - Popov, Yury. PY - 2015/1/1. Y1 - 2015/1/1. N2 - We previously characterized the Mdr2(Abcb4)-/- mouse as a reproducible model of chronic biliary liver disease. However, it demonstrates relatively slow fibrosis progression, possibly due to its fibrosisresistant genetic background. We aimed to improve the model by moving it onto a fibrosis-susceptible background. We generated novel BALB/c.Mdr2-/- mouse via genetic backcross onto highly fibrosissusceptible BALB/c substrain, identified in inbred mouse strain screening. Liver fibrosis, portal pressure, and hepatic tumor burden in BALB/c.Mdr2-/-mice were studied up to 1 year of age in direct comparison to parental strain FVB.Mdr2-/-. BALB/c.Mdr2-/-mice ...
Fatty liver disease: natural treatments.: Pathophysiology Of Fatty Liver And Portal Hypertension. The Fatty Liver Site, Tips and natural treatments for fatty liver.
Tratamiento de la hipertensión portal propranolol dosis hipertension portal y propranolol dosis hipertension portal profilaxis del sangrado de las no se requieren reajustes en la dosis. CARDIOLOGIA . Abstract Objectives. PROPRANOLOL Tabletas Antihiperte - facmed. Unam. Y establecer dosis Todos los contenidos publicados en el portal de salud y medicina. El Propranolol ocasionalmente causa hipoglucemia, la dosis puede ser reducida. Summary of Carvedilol or propranolol in portal hypertension? 2009 recommendations for the treatment of patients with cirrhosis and portal hypertension, dosage or a heart effects of propranolol on portal. Dosage Forms & Strengths. Por este El Carvedilol para amoxicillin and stomach acid la Profilaxis del Sangrado Variceal dosis de propranolol Propranolol-A medical treatment for portal. Propranolol side effects mood changes, propranolol 5mg side effects, prescription free propranolol dosis hipertension portal propranolol, propranolol mechanism of action in portal ...
TY - JOUR. T1 - Portosystemic shunting in children during the era of endoscopic therapy. T2 - Improved postoperative growth parameters. AU - Kato, Tomoaki. AU - Romero, Rene. AU - Koutouby, Raghad. AU - Mittal, Naveen K.. AU - Thompson, John F.. AU - Schleien, Charles L.. AU - Tzakis, Andreas G.. PY - 2000/4/1. Y1 - 2000/4/1. N2 - Background: Surgical portosystemic shunting has been performed less frequently in recent years. In this retrospective study, recent outcomes of portosystemic shunting in children are described, to evaluate its role in the era of endoscopic therapy. Methods: Retrospective chart review of children who underwent surgical portosystemic shunt procedures between October 1994 and October 1997. Results: Twelve children (age range, 1-16 years) underwent shunting procedures. The causes of portal hypertension were extrahepatic portal vein thrombosis (n = 6), congenital hepatic fibrosis (n = 2), hepatic cirrhosis (n = 2), and other (n = 2). None of the patients were immediate ...
Portal hypertension is an increase in the blood pressure within a system of veins called the portal venous system. Veins coming from the stomach, intestine, spleen, and pancreas merge into the portal vein, which then branches into smaller vessels and travels through the liver. If the vessels in the liver are blocked due to liver damage, blood cannot flow properly through the liver. As a result, high pressure in the portal system develops. This increased pressure in the portal vein may lead to the development of large, swollen veins (varices) within the esophagus, stomach, rectum, or umbilical area (belly button). Varices can rupture and bleed, resulting in potentially life-threatening complications. ...
cavernous transformation. A network of collateral vessels may form around a thrombosed main portal vein at the porta, especially if the thrombosis is due to extrahepatic causes (for example pancreatitis) rather than diseased liver. The appearance of cavernous transformation of the PV is quite striking (Fig. A 1) and colour Doppler is particularly useful in its diagnosis. Make sure, before diagnosing PV thrombosis, that the vein axis is less than 60° to the transducer and that the Doppler sensitivity is set to pick up lowvelocity flow. Ultrasound is known to have a falsepositive rate for PV thrombosis but this is often due to inadequate technique or insensitive equipment. False-negative results, indicating that flow is present in a vein which is actually thrombosed, are due to the detection of flow within a collateral vessel at the porta, which can be mistaken for the main ...
TY - JOUR. T1 - Histological subclassification of cirrhosis using the Laennec fibrosis scoring system correlates with clinical stage and grade of portal hypertension. AU - Kim, Moon Young. AU - Cho, Mee Yon. AU - Baik, Soon Koo. AU - Park, Hong Jun. AU - Jeon, Hyo Keun. AU - Im, Chong Kun. AU - Won, Chan Sik. AU - Kim, Jae Woo. AU - Kim, Hyun Soo. AU - Kwon, Sang Ok. AU - Eom, Min Seob. AU - Cha, Seung Hwan. AU - Kim, Young Ju. AU - Chang, Sei Jin. AU - Lee, Samuel S.. PY - 2011/11. Y1 - 2011/11. N2 - Background & Aims: Further histological subclassification of cirrhosis may be useful because of heterogeneity of severity within cirrhosis. We aimed to determine the relationship between histological subclassification and clinical stage of cirrhosis as well as grade of portal hypertension. Methods: One hundred-twenty-three biopsy-proven cirrhosis patients, whose clinical stage of cirrhosis and hepatic venous pressure gradient (HVPG) could be estimated, were included in this prospective study. ...
Portal hypertension (PHT) is a condition with serious complications, such as variceal bleeding, refractory ascites and bowel ischemia. The cause of PHT may be pre-, intra- or post-hepatic. Initial treatment is pressure-reducing drugs and the treatment of acute symptoms.. Ten patients presented with severe abdominal pain and acute portomesenteric venous thrombosis. Their response to systemic anticoagulation was insufficient. Treatment with primary continuous thrombolysis by a transhepatic or transjugular approach in four patients resulted in major complications, incomplete recanalization and a 75% survival rate. Treatment with repeated transjugular thrombectomy (TT) combined with the creation of a transjugular intrahepatic portosystemic shunt (TIPS) achieved near complete recanalization, prompt symptom relief and 100% survival in five patients treated with this method as the primary intervention. In one patient, treated with TT and TIPS secondary to surgical thrombectomy and bowel resection, the ...
Portal hypertension can lead to life-threatening variceal bleeding (VB). Transjugular intrahepatic portosystemic shunt (TIPSS) is the standard choice for uncontrolled VB. Unavailable for TIPSS, we design a mesofemoral shunt (MFS) as an alternative method for control of VB.
Hemodynamic disorders of liver cirrhosis complicated with portal hypertension are associated with an increased angiogenesis in animal model of portal hypertension and cirrhosis which were linked to increased expression of vascular endothelial growth factor (VEGF) and nitric oxide (NO). The aim of study was to evaluate the serum concentration of VEGF and total nitric oxide (NO) in liver cirrhosis and ... Read more. ...
As a transplant surgeon, I actually do more for the care of my patients than just operate. Below is an excerpt from one of my notes describing a woman who unfortunately relapsed into alcoholism after her liver transplant.. Dear Doctors: Mrs. A (not her real initial; her A stands for alcoholic) was admitted to our service last night to evaluate her cough and ascites. As you know, she is a woman with alcoholic cirrhosis status post liver transplant several years ago that was complicated by recurrent alcoholism causing cirrhosis of her liver allograft. She began drinking one year after her transplant and went on to develop end stage liver disease with portal hypertension requiring a TIPS (transjugular intrahepatic portosystemic shunt). Over the past several months she has been readmitted to the hospital with pneumonias and complications related to her liver disease. She continued to drink alcohol despite our admonishments and efforts to get her into alcohol dependency treatment programs. During ...
We report a case of the 59-year-old men with portal hypertension and liver cirrhosis, who developed pulmonary arterial hypertension. The first line treatment with sildenafil 20 mg 3 times daily was introduced as part of a Polish National Treatment Program. At a 6-month follow-up we noticed a significant clinical improvement: the patients exercise capacity and echocardiographic parameters were substantially better. In addition, the B-type natriuretic propeptide significantly decreased. ...
Both pharamacological(B-blocker and isosorbide mononitrate) and endoscopic(banding ligation) treatment have similar results. TIPS(transjugular intrahepatic portosystemic shunting) is superior to either of them at reducing rate of rebleeding. Disadvantages of TIPS include that it is costly, increase risk of hepatic encephalopathy and does not improve mortality ...
Objectives: Evaluation of the outcome and experience in 2 years of management of portal hypertensive gastropathy (PHG) by argon plasma coagulation (APC) in a cohort of Egyptian cirrhotic patients. Methods: This study was conducted over a 2-year period from January 2011 to February 2013. Upper gastrointestinal endoscopy was performed to evaluate the degree and site of PHG. APC was applied to areas with mucosal vascular lesions. Results: In total, 200 cirrhotic patients were enrolled; 12 patients were excluded due to death (n = 6) caused by hepatic encephalopathy (n = 3), hepatorenal syndrome (n = 2), or chronic lymphatic leukemia (n = 1), or did not complete the treatment sessions (n = 6), so 188 patients completed the study ...
Pagina nueva 1 1. Introduction Hepatopulmonary syndrome is a rare complication characterized by liver disease associated with intrapulmonary vascular dilatations and hypoxemia.1 A prevalence of 9-20% has been described in children associated with biliary duct atresia, 0.5% in patients with portal thrombosis2 and 2-8% in cirrhosis and portal hypertension.2,3 Although the condition is uncommon, it is important that the clinician recognizes this disease due its progressive nature.. 2. Clinical case We report the case of an 8-year-old girl without significant perinatal or respiratory history. At 3 of years of age she was diagnosed with liver cirrhosis of unknown etiology. She was hospitalized on multiple occasions due to upper gastrointestinal (GI) bleeding from large esophageal varices. She also had portal hypertension. She was under treatment with furosemide, spirinolactone, propanolol, omeprazole, lactulose and liver transplant protocol for which she presented to the pulmonary service for ...
... is abnormally increased portal venous pressure - blood pressure in the portal vein and its branches, that ... A dilated portal vein (diameter of greater than 13 or 15 mm) is a sign of portal hypertension, with a sensitivity estimated at ... The causes for portal hypertension are classified as originating in the portal venous system before it reaches the liver ( ... portal vein as seen on a CT scan or MRI may raise the suspicion about portal hypertension. A cutoff value of 13 mm is widely ...
Diabetes associated to Hypertension About health portal. 2010-02-09 Medical Journal of Australia. "Hypertension and Diabetes ... Complications of hypertension are clinical outcomes that result from persistent elevation of blood pressure. Hypertension is a ... Treatment of hypertension convincingly decreases the incidence of both ischemic and hemorrhagic strokes. Hypertension is also ... Ergul A (July 2000). "Hypertension in black patients: an emerging role of the endothelin system in salt-sensitive hypertension ...
... (PPH) is defined by the coexistence of portal and pulmonary hypertension. PPH is a serious ... Hadengue, A; Benhayoun, MK; Lebrec, D; Benhamou, JP (February 1991). "Pulmonary hypertension complicating portal hypertension: ... In portal hypertension, blood will shunt from portal to systemic circulation, bypassing the liver. This leaves unmetabolized ... The diagnosis of portopulmonary hypertension is based on hemodynamic criteria:[citation needed] . Portal hypertension and/or ...
This results in portal hypertension. Effects of portal hypertension include: Ascites is a build-up of fluid in the peritoneal ... may suggest underlying portal hypertension. Ultrasound may also screen for hepatocellular carcinoma and portal hypertension. ... Portal hypertensive gastropathy refers to changes in the mucosa of the stomach in people with portal hypertension, and is ... Caput medusae are dilated paraumbilical collateral veins due to portal hypertension. Blood from the portal venous system may be ...
Portal hypertension; Development of new drug treatments for chronic liver disease (incl. the first trial of colchicine in PBC ...
Journal of Hypertension. 37: e57. doi:10.1097/01.hjh.0000570928.33807.a8. ISSN 0263-6352. "Indapamide". Drug Information Portal ... Portal: Medicine (All articles with bare URLs for citations, Articles with bare URLs for citations from March 2022, Articles ... Its indications include hypertension and edema due to congestive heart failure. Indapamide has been shown to reduce stroke ... May 2008). "Treatment of hypertension in patients 80 years of age or older" (PDF). The New England Journal of Medicine. 358 (18 ...
Clinical presentations of portal hypertension include: A dilated inferior mesenteric vein may or may not be related to portal ... In portal hypertension, as in the case of cirrhosis of the liver, the anastomoses become congested and form venous dilatations ... "Surgicomania: Portal Hypertension". surgicomania.blogspot.co.uk. 2009-11-23. Retrieved 2016-08-12. Khader.O.Thabet, Mohammed Al ... "Clinicopathological Features and Treatment of Ectopic Varices with Portal Hypertension". International Journal of Hepatology. ...
... leading to portal hypertension before it is diagnosed. Other symptoms can develop based on the cause. For example, if portal ... Portal vein thrombosis (PVT) is a vascular disease of the liver that occurs when a blood clot occurs in the hepatic portal vein ... The diagnosis of portal vein thrombosis is usually made with imaging confirming a clot in the portal vein; ultrasound is the ... Friedman LS (2020). "Noncirrhotic Portal Hypertension". In Papadakis MA, McPhee SJ, Rabow MW (eds.). Current Medical Diagnosis ...
Child CG, Turcotte JG (1964). "Surgery and portal hypertension". In Child CG (ed.). The liver and portal hypertension. ... MELD Score MELD-Plus The surgeon and portal hypertension expert Charles Gardner Child (1908-1991) (with Turcotte) of the ...
Current management of portal hypertension. Journal of gastrointestinal Surgery. 2005;9(7):992-1005. Sugiura M, and Futagawa S. ...
Hypertension, Dialysis & Clinical Nephrology (1997). "Nordiska Njurdagar (Nordic Nephrology Days)". Hypertension, Dialysis, and ... The Biotech/Life Sciences Portal. Archived from the original on 18 July 2011. Retrieved 3 October 2007. "About Reverse Vending ... Nils Alwall (1997). "Nils Alwall Lecture". Hypertension, Dialysis, and Clinical Nephrology. Retrieved 3 October 2007. Arvid ...
Hypertension, Dialysis & Clinical Nephrology (1997). "Nordiska Njurdagar (Nordic Nephrology Days)". Hypertension, Dialysis, and ... The Biotech/Life Sciences Portal. Archived from the original on July 18, 2011. Retrieved October 3, 2007. Lund University (2005 ... Nils Alwall (1997). "Nils Alwall Lecture". Hypertension, Dialysis, and Clinical Nephrology. Retrieved October 3, 2007. Arvid ... HDCN (2002). "Development of Hemodialysis: From Access to Machine". Hypertension, Dialysis, and Clinical Nephrology. Retrieved ...
In portal hypertension, venous resistance is increased within the portal venous system; when the pressure in the portal venous ... has been shown to alleviate varices caused by portal hypertension. Successful treatment of portal hypertension that ... Typically this occurs due to portal hypertension which shunts venous blood from the portal system through the portosystemic ... Haemorrhoids occur due to prolapse of the rectal venous plexus and are no more common in patients with portal hypertension than ...
Severtsev A. N. "Portal Hypertension" Overview. Klinicheskiy Vestnik, 1997, №3, p. 35-39. Shugurov V. A., Blohin A. P., Malov U ... 5. - p. 4-8. "Portal hypertension" (Severtsev A. N.). "Acute surgical diseases" (manuals for students of fifth-year and sixth- ... "Sclerotherapy of the varicose veins of the esophagus of the patients with portal hypertension" (Manuals). - 2005. p. 27. Brehov ...
Hemihypertrophy Oncovirus Portal hypertension Shetty, Shrimati; Sharma, Nitika; Ghosh, Kanjaksha (2016-03-01). "Epidemiology of ... 8 cm), the presence of portal vein thrombus, tumors with a portal-systemic shunt, and patients with poor liver function.[ ... and portal hypertension) and general health status of the patient (defined by the ECOG classification and the presence of ... Portal vein embolization (PVE): This technique is sometimes used to increase the volume of healthy liver, in order to improve ...
It is also a sign of portal hypertension. It is caused by dilation of the paraumbilical veins, which carry oxygenated blood ... becoming re-canalised due to portal hypertension caused by liver failure. Produces abdominal collateral veins to bypass the ... a unique finding during abdominal examination in patients with portal hypertension; case report". Annals of Medicine and ...
Along its course, it is accompanied by a similarly named vein, the splenic vein, which drains into the hepatic portal vein. ... Risk factors include smoking and hypertension.[4] For the treatment of patients who represent a high surgical risk, ...
"Noncirrhotic presinusoidal portal hypertension associated with chronic arsenical intoxication". Gastroenterology. 68 (5 Pt 1): ...
August 2001). "Human hypertension caused by mutations in WNK kinases". Science. 293 (5532): 1107-12. doi:10.1126/science. ... HumanProteinAtlas/WNK4 GeneCard/WNK4 UniProt/WNK4 OMIM/WNK4 Portal: Biology (Genes on human chromosome 17, EC 2.7.11). ... Arnold JE, Healy JK (September 1969). "Hyperkalemia, hypertension and systemic acidosis without renal failure associated with a ... Gordon RD, Geddes RA, Pawsey CG, O'Halloran MW (November 1970). "Hypertension and severe hyperkalaemia associated with ...
Anti-centromere antibodies often correlate with developing portal hypertension. Anti-np62 and anti-sp100 are also found in ... Stage 1 - portal stage: Normal-sized triads, portal inflammation, subtle bile duct damage: Granulomas are often detected in ...
Anorectal varices due to portal hypertension (blood pressure in the portal venous system) may present similar to hemorrhoids ... Portal hypertension does not increase the risk of hemorrhoids. A number of preventative measures are recommended, including ...
The major criteria include liver disease with portal hypertension; kidney failure; the absence of shock, infection, recent ... Hepatorenal syndrome usually affects individuals with cirrhosis and elevated pressures in the portal vein system (termed portal ... involves the decompression of the high pressures in the portal circulation by placing a small stent between a portal and ... Type 2 HRS is thought to be part of a spectrum of illness associated with increased pressures in the portal vein circulation, ...
"Ambrisentan". Drug Information Portal. U.S. National Library of Medicine. Portal: Medicine (Articles with short description, ... for the treatment of pulmonary hypertension. Ambrisentan is indicated for the treatment of pulmonary arterial hypertension (WHO ... August 2015). "Initial Use of Ambrisentan plus Tadalafil in Pulmonary Arterial Hypertension". The New England Journal of ... June 2008). "Ambrisentan for the treatment of pulmonary arterial hypertension: results of the ambrisentan in pulmonary arterial ...
Disease progression is accompanied by intensifying portal hypertension and hepatosplenomegaly. Clinically, diagnosis generally ... mainly in the portal tracts. Portal tract edema may also occur as a result of bile retention, as well as periductular ... Cholestasis resulting from TPN may also be a result of reduced bile flow from portal endotoxins. With TPN, there is a reduction ... In non-obstructive cholestasis, changes to the portal tracts are unlikely. However, it may occur in some unique situations. In ...
"Hassab's operation as an elective surgical procedure in portal hypertension". Indian J Gastroenterol. 7 (3): 153-4. PMID ... decongestion operation is an elective surgical procedure to treat esophageal varices in patients with portal hypertension as a ...
It decompresses the portal system, reducing portal hypertension and ascites. However, it does not improve the prognosis in ... The condition is found in 5-10% of cirrhosis and portal hypertension cases and 2-3% of all pleural effusions. It is most common ... The most noticeable symptoms are usually those of cirrhosis and portal hypertension. Most people have signs of end-stage liver ... They are similar to the mechanisms behind ascites in cases of portal hypertension. The most medically accepted mechanism is ...
Raised portal venous pressure is termed portal hypertension, and has numerous sequelae such as ascites and hepatic ... 5 mmHg defines portal hypertension, and if the measurement exceeds 10 mmHg it is called clinically significant portal ... Ascites in Cirrhosis Relative Importance of Portal Hypertension and Hypoalbuminemia DONALI) O. CASTELL, LCDR (MC), USN "Portal ... Sauerbruch, T.; Trebicka, J. (2014). "Future therapy of portal hypertension in liver cirrhosis - a guess". F1000Prime Rep. 6: ...
... become distended up to 1-2 cm in diameter in association with portal hypertension.[citation needed] Normal portal pressure is ... They are most often a consequence of portal hypertension, commonly due to cirrhosis. People with esophageal varices have a ... A gradient greater than 5 mmHg is considered portal hypertension. At gradients greater than 10 mmHg, blood flowing through the ... Cushman, James (2018-01-01), Harken, Alden H.; Moore, Ernest E. (eds.), "Chapter 44 - Portal Hypertension and Esophageal ...
"Bing Loyzaga almost had heart attack following hypertension last year". Philippine Entertainment Portal. Retrieved August 31, ... 25". Philippine Entertainment Portal. Archived from the original on October 31, 2009. Retrieved August 31, 2019. "TNS National ... "Geoff Taylor, circle of 16 of Are You the Next Big Star? photo". Philippine Entertainment Portal. Archived from the original on ... TV Ratings (May 26-28): "May Bukas Pa" still leads primetime race". Philippine Entertainment Portal. Retrieved August 31, 2019 ...
Grace ND (July 1997). "Diagnosis and treatment of gastrointestinal bleeding secondary to portal hypertension". American Journal ...
404 Hypertensive heart and renal disease 405 Secondary hypertension 405.0 Malignant secondary hypertension 405.01 Hypertension ... 452 Portal vein thrombosis 453 Other venous embolism and thrombosis 453.4 Deep vein thrombosis, unspec. 453.41 Deep vein ... malignant 401.1 Hypertension, benign 401.9 Hypertension, unspecified 402 Hypertensive heart disease 403 Hypertensive renal ... malignant 405.1 Benign secondary hypertension 405.11 Hypertension, renovascular, benign 410 Acute myocardial infarction 410.0 ...
Excess cortisol is associated with unfavorable health outcomes, such as hypertension, diabetes, osteoporosis, and increased ... International Food Policy Research Institute The Poor Pay More-POVERTY'S HIGH COST TO HEALTH Portals: Medicine Economics ...
Portal: Biology (Articles with short description, Short description is different from Wikidata, All articles with vague or ... Blaustein MP (May 1977). "Sodium ions, calcium ions, blood pressure regulation, and hypertension: a reassessment and a ... Blaustein MP, Hamlyn JM (December 2010). "Signaling mechanisms that link salt retention to hypertension: endogenous ouabain, ...
"Orlistat". Drug Information Portal. U.S. National Library of Medicine. Portal: Medicine (All articles with dead external links ... "Long-term effects of weight-reducing drugs in people with hypertension". The Cochrane Database of Systematic Reviews. 3: ...
Thromboxane-A+Synthase at the US National Library of Medicine Medical Subject Headings (MeSH) Portal: Biology (CS1: long volume ... such as pulmonary hypertension. Because thromboxanes play a role in vasoconstriction and platelet aggregation, their dominance ...
"Levothyroxine". Drug Information Portal. U.S. National Library of Medicine. "Levothyroxine sodium". Drug Information Portal. U. ... Combination of levothyroxine with ketamine may cause hypertension and tachycardia; and tricyclic and tetracyclic ... Portal: Medicine (CS1 German-language sources (de), Articles with short description, Short description matches Wikidata, Use ...
Portal hypertension is often present, and this may lead to the development of prominent veins in many parts of the body, such ...
"Doxepin hydrochloride". Drug Information Portal. U.S. National Library of Medicine. Portal: Medicine (CS1 French-language ... Urinary retention, decreased gastrointestinal motility (paralytic ileus), hyperthermia (or hypothermia), hypertension, dilated ... Media related to Doxepin at Wikimedia Commons "Doxepin". Drug Information Portal. U.S. National Library of Medicine. " ...
Portal Hypertension in the 21st Century: The proceedings of a symposium sponsored by Axcan Pharma Inc. and NicOx S.A., held in ...
Television portal (Articles with short description, Short description is different from Wikidata, Lists of American television ... Her Protestant grandfather died of hypertension when Ruth was 10. This effected her profoundly as she dressed up as Anne of ...
Portal Hypertension (Mohawk Valley Vascular Center) - has some schematics that show what is done in the procedure. (Digestive ... "Update on the Role of TIPS in the Management of Portal Hypertension". Medscape. WebMD LLC. Retrieved March 18, 2006. Khan S, ... It is used to treat portal hypertension and its main complication (esophageal varices). It was developed by W. Dean Warren. ... "Decision-analysis of transjugular intrahepatic portosystemic shunt versus distal splenorenal shunt for portal hypertension". ...
... such as portal hypertension. Acquired hemolytic anemia is also encountered in burns and as a result of certain infections (e.g ... Pulmonary hypertension has been gaining recognition as a complication of chronic hereditary and acquired hemolysis. Free ... This can lead to esophageal spasm and dysphagia, abdominal pain, erectile dysfunction, systemic hypertension, decreased organ ... Machado, Roberto F.; Gladwin, Mark T. (2010). "Pulmonary Hypertension in Hemolytic Disorders". Chest. Elsevier BV. 137 (6): 30S ...
"TIFF.net , Portal to Hell!!!". Archived from the original on December 8, 2015. Retrieved November 29, 2015. "Roddy Piper". ... His death certificate cites a cardiopulmonary arrest caused by hypertension, listing a pulmonary embolism as a contributing ... Portals: Biography Film Television Canada (Articles with short description, Short description is different from Wikidata, Use ... Deaths from hypertension, NWA World Light Heavyweight Champions, NWA Americas Tag Team Champions, NWA Americas Heavyweight ...
Health officials say obesity, diabetes, and hypertension are to blame. On April 4, an article stated that St. John the Baptist ... Coronavirus information from the Louisiana Department of Health Portals: COVID-19 Medicine United States Viruses (Pages using ...
Portal: Biology v t e (Articles with short description, Short description matches Wikidata, Genes on human chromosome X, ... 2001). "Human hypertension caused by mutations in WNK kinases". Science. 293 (5532): 1107-12. doi:10.1126/science.1062844. PMID ...
... one of the more serious complications in patients with an acute decompensation of cirrhosis and increased portal hypertension. ... Sen, S; Mookerjee, RP; Cheshire, LM; Davies, NA; Williams, R; Jalan, R (Jul 2005). "Albumin dialysis reduces portal pressure ... an attenuation of hyperdynamic circulation and a reduction in the portal pressure gradient was measured. Results are summarized ... noted that exclusion of PNF patients is justifiable due to early retransplantation and lack of intercranial hypertension, so ...
... and portal hypertension through mechanisms dependent on osmotically sensitive microRNAs". The American Journal of Pathology. ...
"بوابة وزارة التربية والتعليم المصرية" [The portal of the Egyptian Ministry of Education]. g12.emis.gov.eg. Retrieved 2021-03-22 ... the Egyptian Hypertension Society (EHS) and the International Society of Cardiovascular Ultrasound (ISCU), as well as the Arab ... and celebrating World Hypertension Day (WHD). He has many articles on politics, literature, history and development published ...
Ocular hypertension (increased pressure within the eye) is the most important risk factor for glaucoma, but only about 50% of ... Medicine portal Glaucoma at Curlie GeneReview/NCBI/NIH/UW entry on Primary Congenital Glaucoma (Wikipedia articles needing page ... Ocular hypertension-an intraocular pressure above the traditional threshold of 21 mmHg (2.8 kPa) or even above 24 mmHg (3.2 kPa ... Postoperative ocular hypertension from use of alpha chymotrypsin. Glaucoma of miscellaneous origin Associated with intraocular ...
... hypertension, and diabetes. Howard Barbara V.; Lee Elisa T.; Cowan Linda D.; Devereux Richard B.; Galloway James M.; Go Oscar T ... strongheartstudy.org/portals/1288/Assets/Newsletters/1989%20July.pdf?ver=2018-04-04-110817-460 "Phase III". strongheartstudy. ... in order to monitor changes in risk factor prevalence over time and expand incidence rates beyond CVD to include hypertension ...
... Heart Failure Index Self-Care of Hypertension Inventory Self-Care of Diabetes Inventory Self-Care of Coronary Heart ... Dominic Tyer (28 August 2013). "UK preparing self-care portal for patients". PMLive. PMGroup Worldwide Ltd. Retrieved 31 August ... Dickson, Victoria Vaughan; Fletcher, Jason; Riegel, Barbara (2021). "Psychometric Testing of the Self-care of Hypertension ... Self-care portals and the use of health apps[citation needed] Objective Measures of Specific Self-Care Maintenance Behaviors: ...
"Rasagiline". Drug Information Portal. U.S. National Library of Medicine. "Rasagiline mesylate". Drug Information Portal. U.S. ... Racemic rasagiline was discovered and patented by Aspro Nicholas in the 1970s as a drug candidate for treatment of hypertension ... Portal: Medicine (Articles with short description, Short description matches Wikidata, Drugs with non-standard legal status, ... The FDA label contains warnings that rasagiline may cause severe hypertension or hypotension, may make people sleepy, may make ...
5. Portals: Environment Agriculture and agronomy (CS1 Simplified Chinese-language sources (zh-hans), CS1 errors: missing ... which could contribute to an increase in chronic hypertension. There are many documented incidences of disease outbreaks ...
"Testosterone undecanoate". Drug Information Portal. U.S. National Library of Medicine. Portal: Medicine (Articles with short ... hypertension, elevated liver enzymes, hypertriglyceridemia, and increased sexual desire. The drug is a prodrug of testosterone ...
Official website Family Search Portals: Saints Catholicism Brazil History Biography (Articles with VIAF identifiers, Articles ... her beatification was the 1995 cure of the Brazilian woman Ana Lucia Meirelles who had been healed from pulmonary hypertension ...
Chemistry portal Biology portal Medicine portal Companies portal List of industrial complexes Big Pharma conspiracy theory ... Severe cases of hypertension were treated by surgery. Early developments in the field of treating hypertension included ... Hypertension is a risk factor for atherosclerosis, heart failure, coronary artery disease, stroke, renal disease, and ... Gaddam KK, Verma A, Thompson M, Amin R, Ventura H (May 2009). "Hypertension and cardiac failure in its various forms". The ...
A 92-year-old lady who had asthma and a 43-year-old man who had diabetes, hypertension and heart diseases died on 11 August ... Ministry of Health, Malaysia Official A(H1N1) Portal (in Malay) (EngvarB from September 2014, Use dmy dates from September 2014 ... A 69-year-old woman who had history of hypertension was found to have been coughing. Throat swab was conducted after she was ... Among the six death cases, four of them had been diagnosed with asthma, hypertension and diabetes. As at 12 August 2009 the ...
Other off-label uses for propranolol include the treatment of thyroid storm, portal hypertension, and neuroleptic-induced ... Clonidine (Catapres) for ADHD: clonidine is approved and commonly used for the treatment of hypertension. Other off-label uses ... Prazosin (Minipress) for nightmares: prazosin is approved for the use of hypertension. A 2012 systematic review showed a small ... propranolol is a non-selective beta-blocker used for the treatment of hypertension and the prophylaxis of angina pectoris. In ...
Saudi Arabia portal Arab culture Architecture of Saudi Arabia Tripp, Culture Shock, 2003: p.28 Khelaif, Fahad (1996). Islamic ... hypertension (which affects 33%), and higher rates of severe genetic diseases like cystic fibrosis or a blood disorder, ...
Journal Article Diagnosis, Pathophysiology and Management of Atrial Fibrillation in Cirrhosis and Portal Hypertension ... Splanchnic vasodilation occurs in response to elevated levels of splanchnic nitric oxide with portal hypertension.[13] The ...
Two important factors-vascular resistance and blood flow-exist in the development of portal hypertension. ... Many conditions are associated with portal hypertension, with cirrhosis being the most common cause of this disorder. ... encoded search term (Portal Hypertension) and Portal Hypertension What to Read Next on Medscape ... Redirection of flow through the left gastric vein secondary to portal hypertension or portal venous occlusion. Uphill varices ...
On May 17, 2014 celebrates the World Hypertension Day, promoted by the World Hypertension League. To mark the date, several ... of the results of measurement programs and conducting the first comprehensive population survey by the World Hypertension ...
Learn more about cirrhosis and portal hypertension. Discover the symptoms of these conditions and find information on treatment ... Portal hypertension may cause the spleen to become enlarged. This can cause abdominal discomfort and, because the enlarged ... Other conditions that may develop as a result of portal hypertension include:. *Ascites - the buildup of fluid in the abdomen. ... In newborns, portal hypertension can result from umbilical infection. In cases of chronic pancreatitis and umbilical infection ...
Increased pressure in the pre-hepatic portal vein. [HPO:probinson] ... Treatment of extrahepatic portal hypertension in children by mesenteric-to-left portal vein bypass: a new physiological ... Extrahepatic portal hypertension. Increased pressure in the pre-hepatic portal vein. [HPO:probinson] ... Intrahepatic portal venous systems in children with noncirrhotic prehepatic portal hypertension: anatomy and clinical relevance ...
Portal hypertension is elevated pressure within the portal vein (the vein that carries blood from the digestive organs to the ... Other causes of portal hypertension are thrombosis, or a blood clot that develops in the portal vein. ... The most common cause of portal hypertension is cirrhosis, or scarring of the liver. Cirrhosis is a result of a liver injury ... Increased pressure in the portal vein causes large veins (varices) to develop across the esophagus and stomach to get around ...
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Significance of hemodynamic studies in the evaluation of portal hypertension. Download Prime PubMed App to iPhone, iPad, or ... AdultAgedBlood Pressure DeterminationCollateral CirculationFemaleHemodynamicsHumansHypertension, PortalLiver CirculationLiver ... Smith, G W.. "Significance of Hemodynamic Studies in the Evaluation of Portal Hypertension." The American Surgeon, vol. 39, no ... Smith, G. W. (1973). Significance of hemodynamic studies in the evaluation of portal hypertension. The American Surgeon, 39(1 ...
In both models of portal hypertensive rats, bleeding time was prolonged and thrombi formation, in a laser-induced model of ... portal vein ligation, a model with an almost normal liver, and 30 days of bile duct ligation, a model with cirrhosis and ... Several studies of our laboratory have shown a positive effect in rats with two different experimental models of portal ... Two of them underwent portal vein ligation surgery and developed portal hypertension. In the other two groups, the portal vein ...
Keywords: portal hypertension, acute myeloid leukemia, myeloproliferative disease, splenomegaly, esophageal varices JOURNAL ... A case of portal hypertension complicated with de novo acute myeloid leukemia ... Although portal hypertension has been reportedly associated with myeloproliferative diseases, such as primary myelofibrosis, it ... Abdominal ultrasonography showed a positive portal sandwich sign around the portal vein. Abdominal computed tomography showed ...
Idiopathic Non-Cirrhotic Portal Hypertension , Immunologic Deficiency Syndrome , Natural History of Noncirrhotic Portal ... portal hypertensive gastropathy, splenomegaly, sepsis and ascites. However, unlike cirrhosis related portal hypertension, NCPH ... Noncirrhotic Portal Hypertension (NCPH) is caused by liver diseases that increase pressure in the blood vessels of the liver. ... Noncirrhotic Portal Hypertension (NCPH) includes a spectrum of chronic liver diseases characterized by increased pressure ...
Acute portal hypertension without liver dysfunction enhances bacterial translocation to the lung. *RK Toma1, ... Toma, R., Silva, R., Liberatore, A. et al. Acute portal hypertension without liver dysfunction enhances bacterial translocation ... Thus, in this study we examined the isolated portal hypertension (PH) role, without liver dysfunction, in an experimental BT ... Acute portal hypertension without liver dysfunction enhances bacterial translocation to the lung ...
ii) In ACLD, increased serum CYFRA21-1 associated with the presence of clinically significant portal hypertension (CSPH; HVPG ... From: Serum keratin 19 (CYFRA21-1) links ductular reaction with portal hypertension and outcome of various advanced liver ...
A puzzling case of portal hypertension in a patient with human immunodeficiency and hepatitis C virus co-infection]. ... A liver biopsy, performed for unexpected portal hypertension, showed vascular lesions presenting as nodular regenerative ...
High levels of soluble TNF-alpha-receptor-I are associated with poor outcome in cirrhosis with portal hypertension. / Trebicka ... High levels of soluble TNF-alpha-receptor-I are associated with poor outcome in cirrhosis with portal hypertension. Abstract ... title = "High levels of soluble TNF-alpha-receptor-I are associated with poor outcome in cirrhosis with portal hypertension", ... High levels of soluble TNF-alpha-receptor-I are associated with poor outcome in cirrhosis with portal hypertension. ...
Document degree of portal hypertension, grade of varices, history of bleeding, details on previous banding/ligation. ... Other Conditions - Although mild to moderate and well-controlled chronic conditions (e.g., hypertension, chronic obstructive ... Also for all cases with pulmonary hypertension. Oxygen flow/type should always be documented ... and is available on the IOM-specific UMN web portal upon request. ... IOM Resources (available in different languages at IOM portal ...
Whether carvedilol should be used in patients with portal hypertension and cirrhosis remains controversial. What does the ... Portal hypertension is the primary driver of decompensation, including the development of ascites, hepatic encephalopathy and ... Controversies Surrounding the use of Carvedilol and Other Beta Blockers in the Management of Portal Hypertension and Cirrhosis ... Non-selective beta blockers (NSBB) were introduced as a possible management strategy for complications of portal hypertension ...
In children with portal hypertension, bleeding is linked to the high-risk endoscopic pattern reported here. Primary prophylaxis ... Portal hypertension in children: High-risk varices, primary prophylaxis and consequences of bleeding. ... Primary prophylaxis of bleeding is debated for children with portal hypertension because of the limited number of studies on ... From 1989 to 2014, we managed 1300 children with portal hypertension. Endoscopic features were recorded; high-risk varices were ...
Portal hypertension in children. Indian Pediatrics. 1989 Jan; 26(1): 61-71. ...
The University of Aberdeen Research Portal data protection policy. About web accessibility ... HYPERTENSION - PSYCHOLOGICAL-FACTORS IN ETIOLOGY AND MANAGEMENT. In: Irish Journal of Psychology. 1994 ; Vol. 15, No. 1. pp. 27 ... title = "HYPERTENSION - PSYCHOLOGICAL-FACTORS IN ETIOLOGY AND MANAGEMENT",. abstract = "High blood pressure is the result of ... JOHNSTON, D. W., & Johnston, D. (1994). HYPERTENSION - PSYCHOLOGICAL-FACTORS IN ETIOLOGY AND MANAGEMENT. Irish Journal of ...
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Can Portal Hypertension Be Cured? Blythe Wiers said it very decisively, but Yuri Schewes expression was hypertension drug ... Best Hypertension Medicine! Wang Hong, the king of the East of bp control tablets names in the hypertension medicine list at ... Venous Hypertension Remedies! This is the most powerful super beast in pulmonary hypertension drug of choice the The dragon of ... Free Shipping] Hypertension Drugs And Coq10 What Is The Most Common High Blood Pressure Medicine Hypertension Drugs And Coq10 ...
Portal hypertension. *Liver tumors. *Obstruction of bile ducts. *Cirrhosis. Risks. There is no known risk. You are not exposed ...
PPH is also termed precapillary pulmonary hypertension or, more recently, idiopathic pulmonary arterial hypertension (IPAH). ... Primary pulmonary hypertension (PPH) is a rare disease characterized by elevated pulmonary artery pressure with no apparent ... Pulmonary vascular disease can be associated with portal hypertension (sometimes called portopulmonary hypertension), ... Fast Five Quiz: Pulmonary Arterial Hypertension Treatment * Fast Five Quiz: Pulmonary Arterial Hypertension Presentation and ...
Bradyarrhythmias and hypertension may occur.. Gastrointestinal Abdominal pain, nausea and vomiting are common manifestations of ... Phentolamine for 2-PAM induced hypertension: (5 mg IV for adults; 1 mg IV for children) Diazepam for convulsions: (0.2 to 0.5 ...
Portal hypertension without cirrhosis.. *Fatty degeneration.. Hematological. *Bone marrow hypoplasia.. *Aplastic anemia. ...
Associated with portal hypertension. *. Associated with schistosomiasis. Group 2: Pulmonary hypertension due to left-sided ... "pulmonary hypertension," "pulmonary arterial hypertension," "chronic thromboembolic pulmonary hypertension" and "pulmonary ... Ambrisentan for the treatment of pulmonary arterial hypertension. Results of the Ambrisentan in Pulmonary Arterial Hypertension ... World Health Organization clinical classification of pulmonary hypertension1. Group 1: Pulmonary arterial hypertension ...
Zahger D, Kobrin I, Yeshurun D, Ben-Ishay D. Limitations of the captopril test in the diagnosis of renovascular hypertension. ... Limitations of the captopril test in the diagnosis of renovascular hypertension. D. Zahger, I. Kobrin, D. Yeshurun, D. Ben- ... Limitations of the captopril test in the diagnosis of renovascular hypertension. / Zahger, D.; Kobrin, I.; Yeshurun, D. et al. ... Limitations of the captopril test in the diagnosis of renovascular hypertension. In: Israel Journal of Medical Sciences. 1991 ...
The role of a multidisciplinary team in the management of portal hypertension.. Tseng, Yujen; Ma, Lili; Lv, Minzhi; Luo, ... Gastroesophageal variceal hemorrhage is the most severe complication of portal hypertension, with a high mortality rate. The ... investigate the role of a multidisciplinary team in the management of gastroesophageal varices secondary to portal hypertension ... Varizes Esofágicas e Gástricas/terapia Hemorragia Gastrointestinal/prevenção & controle Hipertensão Portal/terapia Equipe de ...
Find out what causes persistent pulmonary hypertension, a condition that causes a newborns lungs to not function properly ... Pediatric Persistent Pulmonary Hypertension. Pediatric pulmonary hypertension is high blood pressure that builds up in the ... What are the causes of Pediatric Persistent Pulmonary Hypertension?. When a child has pulmonary hypertension, blood pressure on ... What is Pediatric Persistent Pulmonary Hypertension?. Pulmonary hypertension occurs when high blood pressure builds up in ...
  • Pressure on the portal vein causes blood flow to be restricted or pushed backward. (upmc.com)
  • Increased pressure in the pre-hepatic portal vein. (semanticscholar.org)
  • Meso-portal bypass in children with portal vein thrombosis: rapid increase of the intrahepatic portal venous flow after direct portal hepatic reperfusion. (semanticscholar.org)
  • Treatment of extrahepatic portal hypertension in children by mesenteric-to-left portal vein bypass: a new physiological procedure. (semanticscholar.org)
  • Mesenterico-left intrahepatic portal vein shunt: original technique to treat symptomatic extrahepatic portal hypertension. (semanticscholar.org)
  • Portal vein obstruction by ectopic liver tissue. (semanticscholar.org)
  • Portal hypertension is elevated pressure within the portal vein (the vein that carries blood from the digestive organs to the liver). (hoag.org)
  • Increased pressure in the portal vein causes large veins (varices) to develop across the esophagus and stomach to get around the blockage. (hoag.org)
  • Other causes of portal hypertension are thrombosis, or a blood clot that develops in the portal vein. (hoag.org)
  • Several studies of our laboratory have shown a positive effect in rats with two different experimental models of portal hypertension: portal vein ligation, a model with an almost normal liver, and 30 days of bile duct ligation, a model with cirrhosis and presence of ascitis. (hindawi.com)
  • Abdominal ultrasonography showed a positive portal sandwich sign around the portal vein. (go.jp)
  • Abdominal computed tomography showed no evidence of cirrhosis or portal vein obstruction but showed an enlarged left lobe of the liver and splenomegaly. (go.jp)
  • Anticoagulant therapy with enoxaparin can help prevent portal vein thrombosis, reduce the incidence of decompensation and death, and may reduce fibrosis, she said. (ddw.org)
  • Riad Salem, MD, MBA, chief of interventional radiology and vice chair of image-guided therapy at Northwestern University, Chicago, IL, described portal vein recanalization transjugular intrahepatic portosystem shunt (PVR TIPS) for chronic portal vein thrombosis (PVT) in cirrhotic patients. (ddw.org)
  • The prevalence of portal vein thrombosis in cirrhotics ranges from 5 to 26 percent. (ddw.org)
  • The goal of PVT treatment is recanalization of the portal vein to allow end-to-end anastomosis and portal flow at the time of liver transplantation, Dr. Salem explained. (ddw.org)
  • Short TIPS can be placed to maximize unstented portal vein flow for liver transplantations. (ddw.org)
  • The trans-splenic approach to TIPS has become our preferred approach for portal vein recanalization. (ddw.org)
  • During angiography, a catheter is placed selectively via either the transjugular or transfemoral route into the hepatic vein to measure portal pressure. (medscape.com)
  • Esophageal varices develop when normal blood flow to your liver is blocked by a clot to the liver (portal vein thrombosis). (portal-hypertension.com)
  • High blood pressure in the portal vein (portal hypertension) pushes blood into surrounding blood vessels, including vessels in the esophagus. (bnr.co)
  • Esophageal varices are a direct result of high blood pressure in the portal vein. (bnr.co)
  • When increase in the pressure within the portal vein, it leads to hypertension of vein which carries blood from the digestive organs to the liver. (randeepwadhawan.com)
  • This increased pressure of portal vein leads to large veins to develop across the esophagus and stomach to bypass the blockage, causing varicies to bleed and making it very weak. (randeepwadhawan.com)
  • Dr Randeep Wadhawan has vast experience is conducting GI Surgeries including surgery for elevated pressure of portal vein. (randeepwadhawan.com)
  • Portal hypertension is high blood pressure in the portal vein. (ahealthyme.com)
  • This is high blood pressure in the portal vein that can occur when you have a diseased liver. (ahealthyme.com)
  • The portal vein supplies the liver with blood. (ahealthyme.com)
  • Portopulmonary hypertension is a condition in which blood pressure is elevated in the arteries of the lungs, called the pulmonary arteries (pulmonary hypertension), and in the portal vein (which drains blood from the liver), and no cause for pulmonary hypertension can be found. (msdmanuals.com)
  • Portal Hypertension Portal hypertension is abnormally high blood pressure in the portal vein (the large vein that brings blood from the intestine to the liver) and its branches. (msdmanuals.com)
  • Portal hypertension refers to increased blood pressure in the blood vessels supplying the liver (the portal vein). (sgh.com.sg)
  • The hardened liver obstructs blood flow from the portal vein, leading to elevated pressures in the portal vein. (sgh.com.sg)
  • Splenoportography is used to evaluate portal vein patency and the distribution of collateral vessels before shunt operations for cirrhosis. (medscape.com)
  • Portal hypertension is the increased blood pressure in the portal vein, which carries blood from the stomach, intestines and spleen to the liver. (voices.com)
  • Abnormal increase of resistance to blood flow within the hepatic PORTAL SYSTEM , frequently seen in LIVER CIRRHOSIS and conditions with obstruction of the PORTAL VEIN . (bvsalud.org)
  • A practical consideration in implementing the findings of Villanueva et al in clinical practice is to identify patients with compensated cirrhosis and CSPH, as measurements of the hepatic vein portal gradient are not routinely taken at most centers. (practiceupdate.com)
  • In addition, there were no liver abnormalities, no portal vein dilatation, no collateral veins, nor splenomegaly in the abdominal ultrasonography. (cientperiodique.com)
  • An AASLD symposium on the final day of DDW ® 2017 brought together experts from around the world to discuss pharmacological therapies, endoscopic therapies, interventional procedures and the surgical management of portal hypertension (PH) in patients with alcoholic liver disease (ALD). (ddw.org)
  • Book excerpt: Advances in our knowledge of the pathogenesis and management of portal hypertension and its complications over the last 2 decades have been astronomical. (eagles-live.co)
  • There has been great progress in our under standing and management of portal hypertension, particularly in the diagnostic and therapeutic approaches. (eagles-live.co)
  • The main advantages to using vasoactive agents include the ability of these drugs to treat variceal bleeding in the emergency department, lower portal pressure, and offer the endoscopist a clearer view of varices because of less active bleeding. (medscape.com)
  • Through vasoconstriction, somatostatin diminishes blood flow to the portal system, thus decreasing variceal bleeding. (medscape.com)
  • Warren shunts are used for recurrent variceal bleeding, extrahepatic portal hypertension and Child-Pugh class A or B cirrhosis. (ddw.org)
  • Common signs and symptoms may stem from decreased hepatic synthetic function (eg, coagulopathy), portal hypertension (eg, variceal bleeding), or decreased detoxification capabilities of the liver (eg, hepatic encephalopathy). (medscape.com)
  • A myriad of treatment options exists for appropriately managing the most common complications of portal hypertension, including acute variceal bleeding and refractory ascites. (bvsalud.org)
  • Treatment of bleeding esophagogastric varices due to extrahepatic portal hypertension: results of portal-systemic shunts during 35 years. (semanticscholar.org)
  • The complications from NCPH are similar to that of cirrhosis induced portal hypertension which includes the development of gastrointestinal varices, portal hypertensive gastropathy, splenomegaly, sepsis and ascites. (centerwatch.com)
  • The images below depict esophageal varices, which are responsible for the main complication of portal hypertension, upper gastrointestinal (GI) hemorrhage. (medscape.com)
  • Portal hypertension in children: High-risk varices, primary prophylaxis and consequences of bleeding. (snfge.org)
  • In children with liver disease, the risk of bleeding from varices in the esophagus is linked to their large size, the presence of congestion on their surface and their expansion into the stomach but not to the child's age nor to the cause of portal hypertension. (snfge.org)
  • The subject of esophageal varices is by far the most dangerous aspect of portal hypertension. (portal-hypertension.com)
  • This book includes dedicated chapters on gastric varices management, ectopic varices management, sinusoidal obstruction syndrome, portal hypertensive bilopathy, portal hypertension as a risk factor in nonhepatic abdominal surgery, idiopathic portal hypertension, and portal hypertension in pregnancy. (eagles-live.co)
  • Esophageal varices are the major complication of portal hypertension. (bnr.co)
  • If endoscopic techniques fail to stop the bleeding, then minimally invasive or surgical shunt procedures are done by a highly trained laparoscopic gastrointestinal surgeon with an aim to create an alternate pathway for blockage blood flow to relieve portal hypertension and bleeding varices. (randeepwadhawan.com)
  • Higher degrees of esophageal varices and portal hypertensive gastropathy were the significant cause of bleeding in group I (p= 0.001 and 0.02 respectively). (ghrnet.org)
  • Paracentesis is essential in determining whether ascites is caused by portal hypertension or by another process. (medscape.com)
  • Ascites from liver disease often occurs with other liver disease symptoms, such as portal hypertension. (ahealthyme.com)
  • Direct bypassing of extrahepatic portal venous obstruction in children: a new technique for combined hepatic portal revascularization and treatment of extrahepatic portal hypertension. (semanticscholar.org)
  • These findings may derive from deranged portal microvascular dynamics (e.g., increased microvascular pressure, collagen deposition in Disse's space, capillarization of hepatic sinusoids, presinusoidal obstruction) as well as generalized host immunoresponsiveness to schistosomal infection. (arizona.edu)
  • Liver cirrhosis with intrahepatic portal obstruction, HYPERTENSION, and patent UMBILICAL VEINS. (bvsalud.org)
  • Increased resistance to portal flow and increased portal inflow due to mesenteric vasodilatation represent the main factors causing portal hypertension in cirrhosis. (univr.it)
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  • 1 Elevated PA pressure (PAP) can be caused by abnormalities in the precapillary pulmonary arterioles, called pulmonary arterial hypertension (PAH), or by abnormalities that increase left atrial pressure resulting in back pressure on the pulmonary circulation, called pulmonary venous hypertension (PVH). (clevelandclinicmeded.com)
  • The vasoconstrictors somatostatin and octreotide are used to treat acute bleeding in patients with portal hypertension before performing endoscopy. (medscape.com)
  • For patients of UPMC-affiliated doctors in Central Pa, select UPMC Central Pa Portal. (upmc.com)
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  • The authors report on 17 pregnancies of 7 patients with extrahepatic portal hypertension (EPH). (semanticscholar.org)
  • Hemorrhage in portal hypertension is still a lethal complication of cirrhosis in patients in whom clinical decompensation has already developed. (hindawi.com)
  • With increasing recognition both of patients with noncirrhotic portal hypertensive liver diseases, and mortality due to NCPH, it is clear that the specific mechanism(s) and the natural history(s) of noncirrhotic portal hypertensive liver disease have yet to be elucidated and described. (centerwatch.com)
  • At the Clinical Center of the NIH, various cohorts of patients have been identified to be at increased risk for the development of noncirrhotic portal hypertensive liver diseases such as those with Cystic Fibrosis (CF), common variable immunodeficiency (CVID), Turner s Syndrome (TS) and congenital hepatic fibrosis (CHF) to name a few. (centerwatch.com)
  • Thus, in this study we examined the isolated portal hypertension (PH) role, without liver dysfunction, in an experimental BT model at a very acute phase of PH, in order to evaluate whether the infection in cirrhotic patients might be related only to the increased portal blood pressure factor with its consequential intestinal venous congestion. (biomedcentral.com)
  • Circulating microbiome in patients with portal hypertension. (bvsalud.org)
  • In approximately a third of patients with pulmonary arterial hypertension (PAH), Doppler echocardiography demonstrates right-to-left shunting across a patent foramen ovale. (medscape.com)
  • Patients with portal hypertension have been treated with RAS antagonists such as ACE inhibitors, Ang receptor blockers, and aldosterone antagonists, with very promising hemodynamic results. (elsevier.com)
  • In this review, we examine the RAS, its roles in hepatic fibrosis and portal hypertension, and current therapeutic approaches based on the use of RAS antagonists in patients with portal hypertension. (elsevier.com)
  • Patients with portal hypertension represent an important por tion of the daily clinical work of abdominal radiologists, gastroenterologists and abdominal surgeons. (eagles-live.co)
  • During the past two decades the development of new radiological devices and of new percutaneous image-guided treatment methods has resulted in fundamental changes in the clinical management of patients with portal hypertension. (eagles-live.co)
  • During the same period tremen dous progress was achieved in the visualization of the numerous morphological and func tional changes observed in patients with portal hypertension, due to the clinical introduc tion of the new cross-sectional imaging methods: ultrasonography, computed tomography and magnetic resonance imaging. (eagles-live.co)
  • Patients with advanced liver disease can develop high pressure in the veins of the liver, known as portal hypertension. (nm.org)
  • In 60 patients with hepatosplenic schistosomiasis and portal hypertension and in 20 control subjects, the turnover of erythrocytes and lymphocytes circulating in thoracic duct lymph was compared. (arizona.edu)
  • Le présent article décrit les manifestations cliniques, le diagnostic et la prise en charge de la schistosomiase médullaire chez cinq patients admis dans les hôpitaux Shaab et Ibn Khaldoun de Khartoum entre 1997 et 2007. (who.int)
  • Dr. Burghart is part of the research group of Prof. Thomas Reiberger, and his PhD projects focus on the development of portal hypertension and the prognostic impact of clinically significant portal hypertension in patients with rare liver diseases. (easlcampus.eu)
  • 3. Evidence of long-term hepatosplenic involvement by schistosomiasis, via compatible ultrasound findings (peri-portal fibrosis or enlarged left lobe) All patients will necessarily already be receiving at least one specific treatment for PAH, either with phosphodiesterase V inhibitor or with an endothelin receptor antagonist, with a stable dose for at least 12 weeks before inclusion in the study. (who.int)
  • Elle était rétrospective et prospective incluant tous les patients dont l'étude cytologique des liquides d'ascitea mis en évidence des cellules malignes. (bvsalud.org)
  • and TIPS, which allows for portal flow to prevent recurrent thrombosis, but can be technically difficult to perform. (ddw.org)
  • Endothelial cell dysfunction, defined as an imbalance between the synthesis, release, and effect of endothelial mediators of vascular tone, inflammation, thrombosis, and angiogenesis, plays a major role in the increase of resistance in portal circulation, in the decrease in the mesenteric one, in the development of collateral circulation. (univr.it)
  • 1 , 4 WHO group 1 refers to pulmonary arterial hypertension, characterized by the progressive remodelling, narrowing and obliteration of small pulmonary arteries due to proliferation of smooth muscle and endothelial cells, vascular wall inflammation and fibrosis. (cmaj.ca)
  • Reduced response to vasodilators in liver sinusoids and increased response in the mesenteric arterioles, and, viceversa, increased response to vasoconstrictors in the portal-sinusoidal circulation and decreased response in the mesenteric arterioles are also relevant to the pathophysiology of portal hypertension. (univr.it)
  • Idiopathic pulmonary arterial hypertension (IPAH) is a rare disease characterized by elevated pulmonary artery pressure with no apparent cause. (medscape.com)
  • PAH can be associated with any number of other conditions, or can occur in isolation, where it is referred to as idiopathic pulmonary arterial hypertension (IPAH). (nm.org)
  • The captopril test has been suggested as a sensitive and specific noninvasive tool for the diagnosis of renovascular hypertension. (bgu.ac.il)
  • Learning objectives include: identifying risk factors, reviewing the diagnosis of pulmonary hypertension and examining new therapeutic targets and treatment strategies available. (ccs.ca)
  • Pulmonary hypertension is a severe complication of liver cirrhosis, and its diagnosis is a strong indication of the need for liver transplant. (nationaljewish.org)
  • Treatment of hemorrhage risk is pointed to the decrease of elevated portal pressure, mostly by vasoconstrictors, and in some cases to the decrease of elevated liver increased vascular resistance [ 1 ]. (hindawi.com)
  • Despite these studies, the importance of platelet dysfunction to the haemostatic disturbance in cirrhosis has not been completely elucidated nor treatments of hemorrhage in portal hypertension aimed to correct these problems. (hindawi.com)
  • These interaction alterations as well as hemorrhage have been shown to be normalized in experimental portal hypertension models in the rat. (hindawi.com)
  • Cirrhosis of the liver critically affects the liver's ability to function normally and can result in serious, potentially life-threatening complications, such as portal hypertension, liver failure, hemorrhage, and kidney failure . (healthgrades.com)
  • Complications of Portal Hypertension: Hepatorenal Syndrome - Medscape - Dec 05, 2011. (medscape.com)
  • Portal hypertension may cause the spleen to become enlarged. (upmc.com)
  • Portal hypertension complicating abdominal tuberculosis. (uaeu.ac.ae)
  • Dive into the research topics of 'Portal hypertension complicating abdominal tuberculosis. (uaeu.ac.ae)
  • The goals of pharmacotherapy are to reduce mortality and morbidity, and prevent complications associated with acute bleeding related to portal hypertension. (medscape.com)
  • Although portal hypertension has been reportedly associated with myeloproliferative diseases, such as primary myelofibrosis, it has never been reportedly complicated with de novo acute myeloid leukemia. (go.jp)
  • Intrahepatic portal venous systems in children with noncirrhotic prehepatic portal hypertension: anatomy and clinical relevance. (semanticscholar.org)
  • Preemptive meso-rex bypass for children with idiopathic prehepatic portal hypertension: Trick or treat? (elsevier.com)
  • Selective shunts divert gastrosplenic portal flow. (ddw.org)
  • IPAH is also termed WHO Group I pulmonary hypertension (PH), precapillary pulmonary hypertension, and, previously, primary pulmonary hypertension. (medscape.com)
  • But in chronic thromboembolic pulmonary hypertension (CTEPH) , the blood pressure in your lungs can rise, often to dangerous levels. (upmc.com)
  • While this relatively rare condition can be life threatening, there's good news: CTEPH is the only type of pulmonary hypertension that can be completely resolved with surgery in some people. (upmc.com)
  • CTEPH is a form of pulmonary hypertension that can occur when a patient develops a chronic pulmonary embolism , where an embolism ( clot ) gets stuck in one of the lung's blood vessels and turns into scar-like tissue. (upmc.com)
  • When properly treated, people with CTEPH can live as long as those without any history of pulmonary hypertension. (upmc.com)
  • Portal hypertension produced a decreased interaction between platelets and endothelial cells and a prolonged hemorrhagic time. (hindawi.com)
  • Increased thromboxane-A2 production by liver sinusoidal endothelial cells (LSECs) via increased COX-1 activity/expression, increased leukotriens, increased epoxyeicosatrienoic acids (EETs) (dilators of the peripheral arterial circulation, but vasoconstrictors of the portal-sinusoidal circulation), represent a major component in the increased portal resistance, in the decreased portal response to vasodilators and in the hyper-response to vasoconstrictors. (univr.it)
  • What are the signs and symptoms of Pediatric Persistent Pulmonary Hypertension? (childrens.com)
  • Doctors suspect portopulmonary hypertension in people with liver disease based on the symptoms and findings during a physical examination. (msdmanuals.com)
  • Most of the symptoms and signs of liver cirrhosis are a result of the development of portal hypertension. (sgh.com.sg)
  • Conclusion: The COVID-19 cases in Selangor, Malaysia requiring intubation/mechanical ventilation were significantly older, with a higher proportion of hypertension and symptoms of fever, dyspnoea and lethargy. (who.int)
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  • Noncirrhotic Portal Hypertension (NCPH) is caused by liver diseases that increase pressure in the blood vessels of the liver. (centerwatch.com)
  • Pediatric pulmonary hypertension is high blood pressure that builds up in the blood vessels that exchange oxygen between the heart and lungs. (childrens.com)
  • Portal hypertension may be from increased blood pressure in the portal blood vessels. (ahealthyme.com)
  • Portal hypertension can lead to the growth of new blood vessels (collateral blood vessels). (ahealthyme.com)
  • High blood pressure in the blood vessels within your lungs is known as pulmonary hypertension . (upmc.com)
  • However, unlike cirrhosis related portal hypertension, NCPH is characterized by well-preserved hepatic synthetic function. (centerwatch.com)
  • Morpho-biometric aspects of liver cirrhosis and prevalence of portal hypertension in chronic carriers of the hepatitis B virus in Bogodogo (Burkina Faso). (ajol.info)
  • As a Professor of Hepatology he is heading the Liver Outpatient Clinic and runs a Laboratory for Portal Hypertension and Liver Fibrosis at the Medical University of Vienna. (easlcampus.eu)
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  • Pulmonary hypertension occurs when high blood pressure builds up in arteries in the lungs, preventing the heart and lungs from working properly together. (childrens.com)
  • While hypertension (high blood pressure) is generally thought of as an adult disease, a growing number of children are being diagnosed with this condition. (mottchildren.org)
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  • The Pediatric Hypertension Program at C.S. Mott Children's Hospital has multidisciplinary physician expertise to provide a unique comprehensive approach to the evaluation and management of infants, children and adolescents with hypertension. (mottchildren.org)
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  • A Transjugular intrahepatic portal-systemic shunt (TIPS for short) is a wide tube implanted within the liver so that blood is able to flow more quickly. (portal-hypertension.com)
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