An increased reactivity to specific antigens mediated not by antibodies but by cells.
Immunologically mediated adverse reactions to medicinal substances used legally or illegally.
Altered reactivity to an antigen, which can result in pathologic reactions upon subsequent exposure to that particular antigen.
A common interstitial lung disease caused by hypersensitivity reactions of PULMONARY ALVEOLI after inhalation of and sensitization to environmental antigens of microbial, animal, or chemical sources. The disease is characterized by lymphocytic alveolitis and granulomatous pneumonitis.
An abnormality in lung development that is characterized by a multicystic mass resulting from an adenomatous overgrowth of the terminal BRONCHIOLES with a consequent reduction of PULMONARY ALVEOLI. This anomaly is classified into three types by the cyst size.
A peptidyl-dipeptidase that catalyzes the release of a C-terminal dipeptide, -Xaa-*-Xbb-Xcc, when neither Xaa nor Xbb is Pro. It is a Cl(-)-dependent, zinc glycoprotein that is generally membrane-bound and active at neutral pH. It may also have endopeptidase activity on some substrates. (From Enzyme Nomenclature, 1992) EC 3.4.15.1.
Hypersensitivity reactions which occur within minutes of exposure to challenging antigen due to the release of histamine which follows the antigen-antibody reaction and causes smooth muscle contraction and increased vascular permeability.
Irritants and reagents for labeling terminal amino acid groups.
An increased sensation of pain or discomfort produced by mimimally noxious stimuli due to damage to soft tissue containing NOCICEPTORS or injury to a peripheral nerve.
A hapten that generates suppressor cells capable of down-regulating the efferent phase of trinitrophenol-specific contact hypersensitivity. (Arthritis Rheum 1991 Feb;34(2):180).
A contact dermatitis due to allergic sensitization to various substances. These substances subsequently produce inflammatory reactions in the skin of those who have acquired hypersensitivity to them as a result of prior exposure.
Compounds based on a seven-membered ring fused to a five-membered ring. Heat can rearrange them to NAPHTHALENES which have two fused six-membered rings. They are similar to guaiazulenes which are SESQUITERPENES with a six-membered ring fused to a five-membered ring.
Gastrointestinal disturbances, skin eruptions, or shock due to allergic reactions to allergens in food.
Manifestations of the immune response which are mediated by antigen-sensitized T-lymphocytes via lymphokines or direct cytotoxicity. This takes place in the absence of circulating antibody or where antibody plays a subordinate role.
Substances which reduce or eliminate dentinal sensitivity or the pain associated with a source of stimulus (such as touch, heat, or cold) at the orifice of exposed dentinal tubules causing the movement of tubular fluid that in turn stimulates tooth nerve receptors.
Small antigenic determinants capable of eliciting an immune response only when coupled to a carrier. Haptens bind to antibodies but by themselves cannot elicit an antibody response.
Phenomenon of cell-mediated immunity measured by in vitro inhibition of the migration or phagocytosis of antigen-stimulated LEUKOCYTES or MACROPHAGES. Specific CELL MIGRATION ASSAYS have been developed to estimate levels of migration inhibitory factors, immune reactivity against tumor-associated antigens, and immunosuppressive effects of infectious microorganisms.
Amount of stimulation required before the sensation of pain is experienced.
A republic in western Africa, south of BURKINA FASO and west of TOGO. Its capital is Accra.
An acute hypersensitivity reaction due to exposure to a previously encountered ANTIGEN. The reaction may include rapidly progressing URTICARIA, respiratory distress, vascular collapse, systemic SHOCK, and death.
Skin tests in which the sensitizer is injected.
Adverse cutaneous reactions caused by ingestion, parenteral use, or local application of a drug. These may assume various morphologic patterns and produce various types of lesions.
Substances that are recognized by the immune system and induce an immune reaction.
Transfer of immunity from immunized to non-immune host by administration of serum antibodies, or transplantation of lymphocytes (ADOPTIVE TRANSFER).
A form of hypersensitivity affecting the respiratory tract. It includes ASTHMA and RHINITIS, ALLERGIC, SEASONAL.
An immunoglobulin associated with MAST CELLS. Overexpression has been associated with allergic hypersensitivity (HYPERSENSITIVITY, IMMEDIATE).
Aquaporin 2 is a water-specific channel protein that is expressed in KIDNEY COLLECTING DUCTS. The translocation of aquaporin 2 to the apical PLASMA MEMBRANE is regulated by VASOPRESSIN, and MUTATIONS in AQP2 have been implicated in a variety of kidney disorders including DIABETES INSIPIDUS.
A protein extracted from boiled culture of tubercle bacilli (MYCOBACTERIUM TUBERCULOSIS). It is used in the tuberculin skin test (TUBERCULIN TEST) for the diagnosis of tuberculosis infection in asymptomatic persons.
Deliberate stimulation of the host's immune response. ACTIVE IMMUNIZATION involves administration of ANTIGENS or IMMUNOLOGIC ADJUVANTS. PASSIVE IMMUNIZATION involves administration of IMMUNE SERA or LYMPHOCYTES or their extracts (e.g., transfer factor, immune RNA) or transplantation of immunocompetent cell producing tissue (thymus or bone marrow).
A common name used for the genus Cavia. The most common species is Cavia porcellus which is the domesticated guinea pig used for pets and biomedical research.
Intense or aching pain that occurs along the course or distribution of a peripheral or cranial nerve.
Act of eliciting a response from a person or organism through physical contact.
An antigen solution emulsified in mineral oil. The complete form is made up of killed, dried mycobacteria, usually M. tuberculosis, suspended in the oil phase. It is effective in stimulating cell-mediated immunity (IMMUNITY, CELLULAR) and potentiates the production of certain IMMUNOGLOBULINS in some animals. The incomplete form does not contain mycobacteria.
Lymphocytes responsible for cell-mediated immunity. Two types have been identified - cytotoxic (T-LYMPHOCYTES, CYTOTOXIC) and helper T-lymphocytes (T-LYMPHOCYTES, HELPER-INDUCER). They are formed when lymphocytes circulate through the THYMUS GLAND and differentiate to thymocytes. When exposed to an antigen, they divide rapidly and produce large numbers of new T cells sensitized to that antigen.
The group in which legal authority is vested for the control of health-related institutions and organizations.
A skin irritant that may cause dermatitis of both primary and allergic types. Contact sensitization with DNCB has been used as a measure of cellular immunity. DNCB is also used as a reagent for the detection and determination of pyridine compounds.
Redness of the skin produced by congestion of the capillaries. This condition may result from a variety of causes.
A disorder with chronic or recurrent colonic symptoms without a clearcut etiology. This condition is characterized by chronic or recurrent ABDOMINAL PAIN, bloating, MUCUS in FECES, and an erratic disturbance of DEFECATION.
Scales, questionnaires, tests, and other methods used to assess pain severity and duration in patients or experimental animals to aid in diagnosis, therapy, and physiological studies.
The production of ANTIBODIES by proliferating and differentiated B-LYMPHOCYTES under stimulation by ANTIGENS.
Removal of moisture from a substance (chemical, food, tissue, etc.).
An encapsulated lymphatic organ through which venous blood filters.
Antigen-type substances that produce immediate hypersensitivity (HYPERSENSITIVITY, IMMEDIATE).
An albumin obtained from the white of eggs. It is a member of the serpin superfamily.
A dermal inflammatory reaction produced under conditions of antibody excess, when a second injection of antigen produces intravascular antigen-antibody complexes which bind complement, causing cell clumping, endothelial damage, and vascular necrosis.
An evanescent cutaneous reaction occurring when antibody is injected into a local area on the skin and antigen is subsequently injected intravenously along with a dye. The dye makes the rapidly occurring capillary dilatation and increased vascular permeability readily visible by leakage into the reaction site. PCA is a sensitive reaction for detecting very small quantities of antibodies and is also a method for studying the mechanisms of immediate hypersensitivity.
The specific failure of a normally responsive individual to make an immune response to a known antigen. It results from previous contact with the antigen by an immunologically immature individual (fetus or neonate) or by an adult exposed to extreme high-dose or low-dose antigen, or by exposure to radiation, antimetabolites, antilymphocytic serum, etc.
Recirculating, dendritic, antigen-presenting cells containing characteristic racket-shaped granules (Birbeck granules). They are found principally in the stratum spinosum of the EPIDERMIS and are rich in Class II MAJOR HISTOCOMPATIBILITY COMPLEX molecules. Langerhans cells were the first dendritic cell to be described and have been a model of study for other dendritic cells (DCs), especially other migrating DCs such as dermal DCs and INTERSTITIAL DENDRITIC CELLS.
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
A form of alveolitis or pneumonitis due to an acquired hypersensitivity to inhaled avian antigens, usually proteins in the dust of bird feathers and droppings.
An active immunizing agent and a viable avirulent attenuated strain of Mycobacterium tuberculosis, var. bovis, which confers immunity to mycobacterial infections. It is used also in immunotherapy of neoplasms due to its stimulation of antibodies and non-specific immunity.
A cartilage-capped benign tumor that often appears as a stalk on the surface of bone. It is probably a developmental malformation rather than a true neoplasm and is usually found in the metaphysis of the distal femur, proximal tibia, or proximal humerus. Osteochondroma is the most common of benign bone tumors.
Morphologic alteration of small B LYMPHOCYTES or T LYMPHOCYTES in culture into large blast-like cells able to synthesize DNA and RNA and to divide mitotically. It is induced by INTERLEUKINS; MITOGENS such as PHYTOHEMAGGLUTININS, and by specific ANTIGENS. It may also occur in vivo as in GRAFT REJECTION.
Pain originating from internal organs (VISCERA) associated with autonomic phenomena (PALLOR; SWEATING; NAUSEA; and VOMITING). It often becomes a REFERRED PAIN.
White blood cells formed in the body's lymphoid tissue. The nucleus is round or ovoid with coarse, irregularly clumped chromatin while the cytoplasm is typically pale blue with azurophilic (if any) granules. Most lymphocytes can be classified as either T or B (with subpopulations of each), or NATURAL KILLER CELLS.
Skin tests in which the sensitizer is applied to a patch of cotton cloth or gauze held in place for approximately 48-72 hours. It is used for the elicitation of a contact hypersensitivity reaction.
An enzyme capable of hydrolyzing highly polymerized DNA by splitting phosphodiester linkages, preferentially adjacent to a pyrimidine nucleotide. This catalyzes endonucleolytic cleavage of DNA yielding 5'-phosphodi- and oligonucleotide end-products. The enzyme has a preference for double-stranded DNA.
Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.
A polysymptomatic condition believed by clinical ecologists to result from immune dysregulation induced by common foods, allergens, and chemicals, resulting in various physical and mental disorders. The medical community has remained largely skeptical of the existence of this "disease", given the plethora of symptoms attributed to environmental illness, the lack of reproducible laboratory abnormalities, and the use of unproven therapies to treat the condition. (From Segen, Dictionary of Modern Medicine, 1992)
A specific immune response elicited by a specific dose of an immunologically active substance or cell in an organism, tissue, or cell.
Granular leukocytes characterized by a relatively pale-staining, lobate nucleus and cytoplasm containing coarse dark-staining granules of variable size and stainable by basic dyes.
A genus of gram-positive bacteria whose spores are round to oval and covered by a sheath.
Substances of fungal origin that have antigenic activity.
A form of alveolitis or pneumonitis due to an acquired hypersensitivity to inhaled antigens associated with farm environment. Antigens in the farm dust are commonly from bacteria actinomycetes (SACCHAROPOLYSPORA and THERMOACTINOMYCES), fungi, and animal proteins in the soil, straw, crops, pelts, serum, and excreta.
Bites and stings inflicted by insects.
A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.
That portion of the electromagnetic spectrum immediately below the visible range and extending into the x-ray frequencies. The longer wavelengths (near-UV or biotic or vital rays) are necessary for the endogenous synthesis of vitamin D and are also called antirachitic rays; the shorter, ionizing wavelengths (far-UV or abiotic or extravital rays) are viricidal, bactericidal, mutagenic, and carcinogenic and are used as disinfectants.
The forcing into the skin of liquid medication, nutrient, or other fluid through a hollow needle, piercing the top skin layer.
Peripheral AFFERENT NEURONS which are sensitive to injuries or pain, usually caused by extreme thermal exposures, mechanical forces, or other noxious stimuli. Their cell bodies reside in the DORSAL ROOT GANGLIA. Their peripheral terminals (NERVE ENDINGS) innervate target tissues and transduce noxious stimuli via axons to the CENTRAL NERVOUS SYSTEM.
Granulated cells that are found in almost all tissues, most abundantly in the skin and the gastrointestinal tract. Like the BASOPHILS, mast cells contain large amounts of HISTAMINE and HEPARIN. Unlike basophils, mast cells normally remain in the tissues and do not circulate in the blood. Mast cells, derived from the bone marrow stem cells, are regulated by the STEM CELL FACTOR.
Elements of limited time intervals, contributing to particular results or situations.
They are oval or bean shaped bodies (1 - 30 mm in diameter) located along the lymphatic system.
Injuries to the PERIPHERAL NERVES.
Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations, or by parent x offspring matings carried out with certain restrictions. All animals within an inbred strain trace back to a common ancestor in the twentieth generation.
A temperate inducible phage and type species of the genus lambda-like viruses, in the family SIPHOVIRIDAE. Its natural host is E. coli K12. Its VIRION contains linear double-stranded DNA with single-stranded 12-base 5' sticky ends. The DNA circularizes on infection.
A mixture of the enzymes (streptokinase and streptodornase) produced by hemolytic streptococci. It is used topically on surface lesions and by instillation in closed body cavities to remove clotted blood or fibrinous or purulent accumulations. It is also used as a skin test antigen in evaluating generalized cell-mediated immunodeficiency. (Dorland, 27th ed) EC 3.-.
A family of hoofed MAMMALS consisting of HORSES, donkeys, and zebras. Members of this family are strict herbivores and can be classified as either browsers or grazers depending on how they feed.
Substances that augment, stimulate, activate, potentiate, or modulate the immune response at either the cellular or humoral level. The classical agents (Freund's adjuvant, BCG, Corynebacterium parvum, et al.) contain bacterial antigens. Some are endogenous (e.g., histamine, interferon, transfer factor, tuftsin, interleukin-1). Their mode of action is either non-specific, resulting in increased immune responsiveness to a wide variety of antigens, or antigen-specific, i.e., affecting a restricted type of immune response to a narrow group of antigens. The therapeutic efficacy of many biological response modifiers is related to their antigen-specific immunoadjuvanticity.
APOPTOSIS triggered by loss of contact with the EXTRACELLULAR MATRIX.
The hearing and equilibrium system of the body. It consists of three parts: the EXTERNAL EAR, the MIDDLE EAR, and the INNER EAR. Sound waves are transmitted through this organ where vibration is transduced to nerve signals that pass through the ACOUSTIC NERVE to the CENTRAL NERVOUS SYSTEM. The inner ear also contains the vestibular organ that maintains equilibrium by transducing signals to the VESTIBULAR NERVE.
A reagent that is used to neutralize peptide terminal amino groups.
Any of the large interior organs in any one of the three great cavities of the body, especially in the abdomen.
A cylindrical column of tissue that lies within the vertebral canal. It is composed of WHITE MATTER and GRAY MATTER.
Diseases in which skin eruptions or rashes are a prominent manifestation. Classically, six such diseases were described with similar rashes; they were numbered in the order in which they were reported. Only the fourth (Duke's disease), fifth (ERYTHEMA INFECTIOSUM), and sixth (EXANTHEMA SUBITUM) numeric designations survive as occasional synonyms in current terminology.
Immunosuppression by the administration of increasing doses of antigen. Though the exact mechanism is not clear, the therapy results in an increase in serum levels of allergen-specific IMMUNOGLOBULIN G, suppression of specific IgE, and an increase in suppressor T-cell activity.
Deliberate prevention or diminution of the host's immune response. It may be nonspecific as in the administration of immunosuppressive agents (drugs or radiation) or by lymphocyte depletion or may be specific as in desensitization or the simultaneous administration of antigen and immunosuppressive drugs.
The outer part of the hearing system of the body. It includes the shell-like EAR AURICLE which collects sound, and the EXTERNAL EAR CANAL, the TYMPANIC MEMBRANE, and the EXTERNAL EAR CARTILAGES.
Dentifrices that are formulated into a paste form. They typically contain abrasives, HUMECTANTS; DETERGENTS; FLAVORING AGENTS; and CARIOSTATIC AGENTS.
Substances elaborated by bacteria that have antigenic activity.
An anticonvulsant used to control grand mal and psychomotor or focal seizures. Its mode of action is not fully understood, but some of its actions resemble those of PHENYTOIN; although there is little chemical resemblance between the two compounds, their three-dimensional structure is similar.
A vascular reaction of the skin characterized by erythema and wheal formation due to localized increase of vascular permeability. The causative mechanism may be allergy, infection, or stress.
The bovine variety of the tubercle bacillus. It is called also Mycobacterium tuberculosis var. bovis.
Non-antibody proteins secreted by inflammatory leukocytes and some non-leukocytic cells, that act as intercellular mediators. They differ from classical hormones in that they are produced by a number of tissue or cell types rather than by specialized glands. They generally act locally in a paracrine or autocrine rather than endocrine manner.
Nonsusceptibility to the invasive or pathogenic effects of foreign microorganisms or to the toxic effect of antigenic substances.
Introduction of therapeutic agents into the spinal region using a needle and syringe.
Allergic reaction to milk (usually cow's milk) or milk products. MILK HYPERSENSITIVITY should be differentiated from LACTOSE INTOLERANCE, an intolerance to milk as a result of congenital deficiency of lactase.
Compounds capable of relieving pain without the loss of CONSCIOUSNESS.
Rare cutaneous eruption characterized by extensive KERATINOCYTE apoptosis resulting in skin detachment with mucosal involvement. It is often provoked by the use of drugs (e.g., antibiotics and anticonvulsants) or associated with PNEUMONIA, MYCOPLASMA. It is considered a continuum of Toxic Epidermal Necrolysis.
Specialized afferent neurons capable of transducing sensory stimuli into NERVE IMPULSES to be transmitted to the CENTRAL NERVOUS SYSTEM. Sometimes sensory receptors for external stimuli are called exteroceptors; for internal stimuli are called interoceptors and proprioceptors.
Nucleosides that have two hydroxy groups removed from the sugar moiety. The majority of these compounds have broad-spectrum antiretroviral activity due to their action as antimetabolites. The nucleosides are phosphorylated intracellularly to their 5'-triphosphates and act as chain-terminating inhibitors of viral reverse transcription.
A histamine H1 antagonist used as an antiemetic, antitussive, for dermatoses and pruritus, for hypersensitivity reactions, as a hypnotic, an antiparkinson, and as an ingredient in common cold preparations. It has some undesired antimuscarinic and sedative effects.
Congenital disorder affecting all bone marrow elements, resulting in ANEMIA; LEUKOPENIA; and THROMBOPENIA, and associated with cardiac, renal, and limb malformations as well as dermal pigmentary changes. Spontaneous CHROMOSOME BREAKAGE is a feature of this disease along with predisposition to LEUKEMIA. There are at least 7 complementation groups in Fanconi anemia: FANCA, FANCB, FANCC, FANCD1, FANCD2, FANCE, FANCF, FANCG, and FANCL. (from Online Mendelian Inheritance in Man, http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=227650, August 20, 2004)
A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.
Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.
Sensory ganglia located on the dorsal spinal roots within the vertebral column. The spinal ganglion cells are pseudounipolar. The single primary branch bifurcates sending a peripheral process to carry sensory information from the periphery and a central branch which relays that information to the spinal cord or brain.
Increased sensitivity to cutaneous stimulation due to a diminished threshold or an increased response to stimuli.
A relatively small nodular inflammatory lesion containing grouped mononuclear phagocytes, caused by infectious and noninfectious agents.
The space in the eye, filled with aqueous humor, bounded anteriorly by the cornea and a small portion of the sclera and posteriorly by a small portion of the ciliary body, the iris, and that part of the crystalline lens which presents through the pupil. (Cline et al., Dictionary of Visual Science, 4th ed, p109)
A bacteriostatic antibacterial agent that interferes with folic acid synthesis in susceptible bacteria. Its broad spectrum of activity has been limited by the development of resistance. (From Martindale, The Extra Pharmacopoeia, 30th ed, p208)
The major immunoglobulin isotype class in normal human serum. There are several isotype subclasses of IgG, for example, IgG1, IgG2A, and IgG2B.
Neurons in the SPINAL CORD DORSAL HORN whose cell bodies and processes are confined entirely to the CENTRAL NERVOUS SYSTEM. They receive collateral or direct terminations of dorsal root fibers. They send their axons either directly to ANTERIOR HORN CELLS or to the WHITE MATTER ascending and descending longitudinal fibers.
The major interferon produced by mitogenically or antigenically stimulated LYMPHOCYTES. It is structurally different from TYPE I INTERFERON and its major activity is immunoregulation. It has been implicated in the expression of CLASS II HISTOCOMPATIBILITY ANTIGENS in cells that do not normally produce them, leading to AUTOIMMUNE DISEASES.
One of several skin tests to determine past or present tuberculosis infection. A purified protein derivative of the tubercle bacilli, called tuberculin, is introduced into the skin by scratch, puncture, or interdermal injection.
Severe drug eruption characterized by high fever, erythematous rash and inflammation of internal organ(s).
The relatively long-lived phagocytic cell of mammalian tissues that are derived from blood MONOCYTES. Main types are PERITONEAL MACROPHAGES; ALVEOLAR MACROPHAGES; HISTIOCYTES; KUPFFER CELLS of the liver; and OSTEOCLASTS. They may further differentiate within chronic inflammatory lesions to EPITHELIOID CELLS or may fuse to form FOREIGN BODY GIANT CELLS or LANGHANS GIANT CELLS. (from The Dictionary of Cell Biology, Lackie and Dow, 3rd ed.)
Compounds with three aromatic rings in linear arrangement with a SULFUR in the center ring.
Abnormal fluid accumulation in TISSUES or body cavities. Most cases of edema are present under the SKIN in SUBCUTANEOUS TISSUE.
CD4-positive T cells that inhibit immunopathology or autoimmune disease in vivo. They inhibit the immune response by influencing the activity of other cell types. Regulatory T-cells include naturally occurring CD4+CD25+ cells, IL-10 secreting Tr1 cells, and Th3 cells.
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
The relationship between the dose of an administered drug and the response of the organism to the drug.
Loss of the tooth substance by chemical or mechanical processes
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
The segment of LARGE INTESTINE between the CECUM and the RECTUM. It includes the ASCENDING COLON; the TRANSVERSE COLON; the DESCENDING COLON; and the SIGMOID COLON.
The observable response an animal makes to any situation.
Antibodies which elicit IMMUNOPRECIPITATION when combined with antigen.
Posture while lying with the head lower than the rest of the body. Extended time in this position is associated with temporary physiologic disturbances.
The serous fluid of ASCITES, the accumulation of fluids in the PERITONEAL CAVITY.
A form of fluorescent antibody technique commonly used to detect serum antibodies and immune complexes in tissues and microorganisms in specimens from patients with infectious diseases. The technique involves formation of an antigen-antibody complex which is labeled with fluorescein-conjugated anti-immunoglobulin antibody. (From Bennington, Saunders Dictionary & Encyclopedia of Laboratory Medicine and Technology, 1984)
The distal segment of the LARGE INTESTINE, between the SIGMOID COLON and the ANAL CANAL.
Serological reactions in which an antiserum against one antigen reacts with a non-identical but closely related antigen.
A subgroup of TRP cation channels named after vanilloid receptor. They are very sensitive to TEMPERATURE and hot spicy food and CAPSAICIN. They have the TRP domain and ANKYRIN repeats. Selectivity for CALCIUM over SODIUM ranges from 3 to 100 fold.
Immunoglobulin molecules having a specific amino acid sequence by virtue of which they interact only with the ANTIGEN (or a very similar shape) that induced their synthesis in cells of the lymphoid series (especially PLASMA CELLS).
A psychotic disorder characterized by the patient's belief that acquaintances or closely related persons have been replaced by doubles or imposters.
A diverse group of proteins whose genetic MUTATIONS have been associated with the chromosomal instability syndrome FANCONI ANEMIA. Many of these proteins play important roles in protecting CELLS against OXIDATIVE STRESS.
Injuries to DNA that introduce deviations from its normal, intact structure and which may, if left unrepaired, result in a MUTATION or a block of DNA REPLICATION. These deviations may be caused by physical or chemical agents and occur by natural or unnatural, introduced circumstances. They include the introduction of illegitimate bases during replication or by deamination or other modification of bases; the loss of a base from the DNA backbone leaving an abasic site; single-strand breaks; double strand breaks; and intrastrand (PYRIMIDINE DIMERS) or interstrand crosslinking. Damage can often be repaired (DNA REPAIR). If the damage is extensive, it can induce APOPTOSIS.
Presence of warmth or heat or a temperature notably higher than an accustomed norm.
A recurrent contact dermatitis caused by substances found in the work place.
The etiologic agent of rat leprosy, also known as murine leprosy.
The sensation of cold, heat, coolness, and warmth as detected by THERMORECEPTORS.
The reconstruction of a continuous two-stranded DNA molecule without mismatch from a molecule which contained damaged regions. The major repair mechanisms are excision repair, in which defective regions in one strand are excised and resynthesized using the complementary base pairing information in the intact strand; photoreactivation repair, in which the lethal and mutagenic effects of ultraviolet light are eliminated; and post-replication repair, in which the primary lesions are not repaired, but the gaps in one daughter duplex are filled in by incorporation of portions of the other (undamaged) daughter duplex. Excision repair and post-replication repair are sometimes referred to as "dark repair" because they do not require light.
Serum albumin from cows, commonly used in in vitro biological studies. (From Stedman, 25th ed)
Allergic reaction to eggs that is triggered by the immune system.
Resistance to a disease-causing agent induced by the introduction of maternal immunity into the fetus by transplacental transfer or into the neonate through colostrum and milk.
Any preparations used for cleansing teeth; they usually contain an abrasive, detergent, binder and flavoring agent and may exist in the form of liquid, paste or powder; may also contain medicaments and caries preventives.
A treatment technique utilizing play as a medium for expression and communication between patient and therapist.
Any inflammation of the skin.
A sulfone active against a wide range of bacteria but mainly employed for its actions against MYCOBACTERIUM LEPRAE. Its mechanism of action is probably similar to that of the SULFONAMIDES which involves inhibition of folic acid synthesis in susceptible organisms. It is also used with PYRIMETHAMINE in the treatment of malaria. (From Martindale, The Extra Pharmacopoeia, 30th ed, p157-8)
Movement of tethered, spherical LEUKOCYTES along the endothelial surface of the microvasculature. The tethering and rolling involves interaction with SELECTINS and other adhesion molecules in both the ENDOTHELIUM and leukocyte. The rolling leukocyte then becomes activated by CHEMOKINES, flattens out, and firmly adheres to the endothelial surface in preparation for transmigration through the interendothelial cell junction. (From Abbas, Cellular and Molecular Immunology, 3rd ed)
A water-soluble extractive mixture of sulfated polysaccharides from RED ALGAE. Chief sources are the Irish moss CHONDRUS CRISPUS (Carrageen), and Gigartina stellata. It is used as a stabilizer, for suspending COCOA in chocolate manufacture, and to clarify BEVERAGES.
Proteins released by sensitized LYMPHOCYTES and possibly other cells that inhibit the migration of MACROPHAGES away from the release site. The structure and chemical properties may vary with the species and type of releasing cell.
Contractions of the abdominal muscles upon stimulation of the skin (superficial abdominal reflex) or tapping neighboring bony structures (deep abdominal reflex). The superficial reflex may be weak or absent, for example, after a stroke, a sign of upper (suprasegmental) motor neuron lesions. (Stedman, 25th ed & Best & Taylor's Physiological Basis of Medical Practice, 12th ed, p1073)
Subset of helper-inducer T-lymphocytes which synthesize and secrete interleukin-2, gamma-interferon, and interleukin-12. Due to their ability to kill antigen-presenting cells and their lymphokine-mediated effector activity, Th1 cells are associated with vigorous delayed-type hypersensitivity reactions.
Allergic reaction to peanuts that is triggered by the immune system.
The act of dilating.
Form of passive immunization where previously sensitized immunologic agents (cells or serum) are transferred to non-immune recipients. When transfer of cells is used as a therapy for the treatment of neoplasms, it is called adoptive immunotherapy (IMMUNOTHERAPY, ADOPTIVE).
The application of suitable drug dosage forms to the skin for either local or systemic effects.
Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the LIVER to form the active aldophosphamide. It has been used in the treatment of LYMPHOMA and LEUKEMIA. Its side effect, ALOPECIA, has been used for defleecing sheep. Cyclophosphamide may also cause sterility, birth defects, mutations, and cancer.
A Fanconi anemia complementation group protein that regulates the activities of CYTOCHROME P450 REDUCTASE and GLUTATHIONE S-TRANSFERASE. It is found predominately in the CYTOPLASM, but moves to the CELL NUCLEUS in response to FANCE PROTEIN.
A soluble factor produced by activated T-LYMPHOCYTES that induces the expression of MHC CLASS II GENES and FC RECEPTORS on B-LYMPHOCYTES and causes their proliferation and differentiation. It also acts on T-lymphocytes, MAST CELLS, and several other hematopoietic lineage cells.
Any preparations used for cleansing teeth; they usually contain an abrasive, detergent, binder and flavoring agent and may exist in the form of liquid, paste or powder; may also contain medicaments and caries preventives.
Any of several BRASSICA species that are commonly called mustard. Brassica alba is white mustard, B. juncea is brown or Chinese mustard, and B. nigra is black, brown, or red mustard. The plant is grown both for mustard seed from which oil is extracted or used as SPICES, and for its greens used as VEGETABLES or ANIMAL FEED. There is no relationship to MUSTARD COMPOUNDS.
Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood.
Agents that are used to treat allergic reactions. Most of these drugs act by preventing the release of inflammatory mediators or inhibiting the actions of released mediators on their target cells. (From AMA Drug Evaluations Annual, 1994, p475)
Serum globulins that migrate to the gamma region (most positively charged) upon ELECTROPHORESIS. At one time, gamma-globulins came to be used as a synonym for immunoglobulins since most immunoglobulins are gamma globulins and conversely most gamma globulins are immunoglobulins. But since some immunoglobulins exhibit an alpha or beta electrophoretic mobility, that usage is in decline.
Oils which are used in industrial or commercial applications.
Traumatic injuries to the ACCESSORY NERVE. Damage to the nerve may produce weakness in head rotation and shoulder elevation.
An alkylamide found in CAPSICUM that acts at TRPV CATION CHANNELS.
Immunoglobulins produced in a response to FUNGAL ANTIGENS.
Resistance to a disease agent resulting from the production of specific antibodies by the host, either after exposure to the disease or after vaccination.
Granulomatous disorders affecting one or more sites in the respiratory tract.
The distal extremity of the leg in vertebrates, consisting of the tarsus (ANKLE); METATARSUS; phalanges; and the soft tissues surrounding these bones.
Chronic or recurrent colonic disorders without an identifiable structural or biochemical explanation. The widely recognized IRRITABLE BOWEL SYNDROME falls into this category.
The process by which PAIN is recognized and interpreted by the brain.
Dermatologic disorders attendant upon non-dermatologic disease or injury.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
Drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine. Included here are the classical antihistaminics that antagonize or prevent the action of histamine mainly in immediate hypersensitivity. They act in the bronchi, capillaries, and some other smooth muscles, and are used to prevent or allay motion sickness, seasonal rhinitis, and allergic dermatitis and to induce somnolence. The effects of blocking central nervous system H1 receptors are not as well understood.
A mitosporic Tremellales fungal genus whose species usually have a capsule and do not form pseudomycellium. Teleomorphs include Filobasidiella and Fidobasidium.
A subacute or chronic inflammatory disease of muscle and skin, marked by proximal muscle weakness and a characteristic skin rash. The illness occurs with approximately equal frequency in children and adults. The skin lesions usually take the form of a purplish rash (or less often an exfoliative dermatitis) involving the nose, cheeks, forehead, upper trunk, and arms. The disease is associated with a complement mediated intramuscular microangiopathy, leading to loss of capillaries, muscle ischemia, muscle-fiber necrosis, and perifascicular atrophy. The childhood form of this disease tends to evolve into a systemic vasculitis. Dermatomyositis may occur in association with malignant neoplasms. (From Adams et al., Principles of Neurology, 6th ed, pp1405-6)
A non-allergic contact dermatitis caused by prolonged exposure to irritants and not explained by delayed hypersensitivity mechanisms.
An antineoplastic antibiotic produced by Streptomyces caespitosus. It is one of the bi- or tri-functional ALKYLATING AGENTS causing cross-linking of DNA and inhibition of DNA synthesis.
Diseases of the peripheral nerves external to the brain and spinal cord, which includes diseases of the nerve roots, ganglia, plexi, autonomic nerves, sensory nerves, and motor nerves.
The processes triggered by interactions of ANTIBODIES with their ANTIGENS.
Abnormal increase of EOSINOPHILS in the blood, tissues or organs.
Class I human histocompatibility (HLA) surface antigens encoded by more than 30 detectable alleles on locus B of the HLA complex, the most polymorphic of all the HLA specificities. Several of these antigens (e.g., HLA-B27, -B7, -B8) are strongly associated with predisposition to rheumatoid and other autoimmune disorders. Like other class I HLA determinants, they are involved in the cellular immune reactivity of cytolytic T lymphocytes.
Benzene derivatives which are substituted with three nitro groups in any position.
Disease or damage involving the SCIATIC NERVE, which divides into the PERONEAL NERVE and TIBIAL NERVE (see also PERONEAL NEUROPATHIES and TIBIAL NEUROPATHY). Clinical manifestations may include SCIATICA or pain localized to the hip, PARESIS or PARALYSIS of posterior thigh muscles and muscles innervated by the peroneal and tibial nerves, and sensory loss involving the lateral and posterior thigh, posterior and lateral leg, and sole of the foot. The sciatic nerve may be affected by trauma; ISCHEMIA; COLLAGEN DISEASES; and other conditions. (From Adams et al., Principles of Neurology, 6th ed, p1363)
Allergic reaction to tree nuts that is triggered by the immune system.
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
An acquired disorder characterized by recurrent symptoms, referable to multiple organ systems, occurring in response to demonstrable exposure to many chemically unrelated compounds at doses below those established in the general population to cause harmful effects. (Cullen MR. The worker with multiple chemical sensitivities: an overview. Occup Med 1987;2(4):655-61)
A cyclic nucleotide phosphodiesterase subfamily that is highly specific for CYCLIC GMP. It is found predominantly in vascular tissue and plays an important role in regulating VASCULAR SMOOTH MUSCLE contraction.
A cytokine produced by a variety of cell types, including T-LYMPHOCYTES; MONOCYTES; DENDRITIC CELLS; and EPITHELIAL CELLS that exerts a variety of effects on immunoregulation and INFLAMMATION. Interleukin-10 combines with itself to form a homodimeric molecule that is the biologically active form of the protein.
Organic compounds that contain the -NCO radical.
A genus of asporogenous bacteria isolated from soil that displays a distinctive rod-coccus growth cycle.
Organized groups of users of goods and services.

Activity in saline of phthalylated or succinylated derivatives of mycobacterial water-soluble adjuvant. (1/2874)

A water-soluble fraction (WSA) of the cell wall can substitute for mycobacterial cells in Freund complete adjuvant. However, when WSA is administered in saline instead of in a water-in-oil emulsion, its adjuvant activity is very weak, and under certain experimental conditions it can even inhibit the humoral immune response. The data reported in the present study show that after treatment by phthalic or succinic anhydride the adjuvant activity of WSA was markedly changed, since high levels of circulating antibodies were produced when these derivatives were administered with an antigen in an aqueous medium. Moreover, the antigenic determinants of WSA were modified and acylated WSA had no tuberculin-like activity.  (+info)

N,N'-Diacetyl-L-cystine-the disulfide dimer of N-acetylcysteine-is a potent modulator of contact sensitivity/delayed type hypersensitivity reactions in rodents. (2/2874)

Oral N-acetyl-L-cysteine (NAC) is used clinically for treatment of chronic obstructive pulmonary disease. NAC is easily oxidized to its disulfide. We show here that N,N'-diacetyl-L-cystine (DiNAC) is a potent modulator of contact sensitivity (CS)/delayed type hypersensitivity (DTH) reactions in rodents. Oral treatment of BALB/c mice with 0.003 to 30 micromol/kg DiNAC leads to enhancement of a CS reaction to oxazolone; DiNAC is 100 to 1000 times more potent than NAC in this respect, indicating that it does not act as a prodrug of NAC. Structure-activity studies suggest that a stereochemically-defined disulfide element is needed for activity. The DiNAC-induced enhancement of the CS reaction is counteracted by simultaneous NAC-treatment; in contrast, the CS reaction is even more enhanced in animals treated with DiNAC together with the glutathione-depleting agent buthionine sulfoximine. These data suggest that DiNAC acts via redox processes. Immunohistochemically, ear specimens from oxazolone-sensitized and -challenged BALB/c mice treated with DiNAC display increased numbers of CD8(+) cells. DiNAC treatment augments the CS reaction also when fluorescein isothiocyanate is used as a sensitizer in BALB/c mice; this is a purported TH2 type of response. However, when dinitrofluorobenzene is used as a sensitizer, inducing a purported TH1 type of response, DiNAC treatment reduces the reaction. Treatment with DiNAC also reduces a DTH footpad-swelling reaction to methylated BSA. Collectively, these data indicate that DiNAC in vivo acts as a potent and effective immunomodulator that can either enhance or reduce the CS or DTH response depending on the experimental conditions.  (+info)

Effect of tripterine on collagen-induced arthritis in rats. (3/2874)

AIM: To study the therapeutic effect of tripterine (Tri) on collagen-induced arthritis (CIA). METHODS: Collagen type II (Col) 1.5 mg was injected intradermally to induce CIA in rats. Hind paw volumes of rats were measured with a water displacement method. The serum anti-collagen antibody was measured by an enzyme-linked immunosorbent assay. Delayed hypersensitivity was reflected by skin response to Col. Interleukin-1 (IL-1) and interleukin-2 (IL-2) activities were evaluated by [3H]TdR uptake. Joint was evaluated histologically. RESULTS: Tri 15 and 30 mg.kg-1.d-1 given i.g. to rats 3 d after the first sign of arthritis reduced inflammatory swelling, suppressed humoral and skin response to Col, inhibited IL-2 and IL-1 production, reduced pathological progression of joint. CONCLUSION: Tri has a therapeutic effect on CIA.  (+info)

Effects of interleukin-1 receptor antagonist overexpression on infection by Listeria monocytogenes. (4/2874)

Interleukin-1 receptor antagonist (IL-1ra) is a naturally occurring cytokine whose only known function is the inhibition of interleukin-1 (IL-1). Using a reverse genetic approach in mice, we previously showed that increasing IL-1ra gene dosage leads to reduced survival of a primary listerial infection. In this study, we characterize further the role of endogenously produced IL-1ra and, by inference, IL-1 in murine listeriosis. IL-1ra overexpression inhibits, but does not eliminate, primary immune responses, reducing survival and increasing bacterial loads in the target organs. We demonstrate that IL-1ra functions in the innate immune response to regulate the peak leukocyte levels in the blood, the accumulation of leukocytes at sites of infection, and the activation of macrophages during a primary infection. Reduced macrophage class II major histocompatibility complex expression was observed despite increased gamma interferon (IFN-gamma) levels, suggesting that IL-1 activity is essential along with IFN-gamma for macrophage activation in vivo. We also show that IL-1ra plays a more limited role during secondary listeriosis, blunting the strength of the delayed-type hypersensitivity response to listerial antigen while not significantly altering cellular immunity to a second infectious challenge. When these results are compared to those for other mutant mice, IL-1ra appears to be unique among the cytokines studied to date in its regulation of leukocyte migration during primary listeriosis.  (+info)

Differential avian and human tuberculin skin testing in non-tuberculous mycobacterial infection. (5/2874)

OBJECTIVE: To determine the sensitivity of differential avian and human delayed-type hypersensitivity skin testing in the diagnosis of non-tuberculous mycobacterial lymphadenitis. METHOD: Retrospective review of all patients with culture proved non-tuberculous mycobacterial lymph node infections who also had differential avian and human skin testing performed over a 10 year period from 1986 to 1996. RESULTS: One hundred and twenty four patients had non-tuberculous mycobacteria isolated from lymph nodes over this period, 59 of whom had differential skin testing performed. The sensitivity of a response of >/= 10 mm to the avian precipitin was 58 of 59. No patient had both a negative human and avian Mantoux. The sensitivity of the human Mantoux alone for diagnosing non-tuberculous mycobacterial infection was 81% for a response of >/= 5 mm and 66% for >/= 10 mm. Ten patients had a 0 human response. Fifty five of the 59 patients had an avian response at least 2 mm greater than the human response. CONCLUSION: The avian Mantoux is a very sensitive method of diagnosing non-tuberculous mycobacterial infection in children. The human Mantoux is not sensitive enough to be used alone as a surrogate to diagnose non-tuberculous mycobacterial infection.  (+info)

Structural deficiencies in granuloma formation in TNF gene-targeted mice underlie the heightened susceptibility to aerosol Mycobacterium tuberculosis infection, which is not compensated for by lymphotoxin. (6/2874)

TNF and lymphotoxin-alpha (LT alpha) may act at various stages of the host response to Mycobacterium tuberculosis. To dissect the effects of TNF independent of LT alpha, we have used C57BL/6 mice with a disruption of the TNF gene alone (TNF-/-). Twenty-one days following aerosol M. tuberculosis infection there was a marked increase in the number of organisms in the lungs of TNF-/- mice, and by 28-35 days all animals had succumbed, with widespread dissemination of M. tuberculosis. In comparison with the localized granulomas containing activated macrophages and T cells in lungs and livers of C57BL/6 wild-type (wt) mice, cellular infiltrates in TNF-/- mice were poorly formed, with extensive regions of necrosis and neutrophilic infiltration of the alveoli. Phenotypic analysis of lung homogenates demonstrated similar numbers of CD4+ and CD8+ T cells in TNF-/- and wt mice, but in TNF-deficient mice the lymphocytes were restricted to perivascular and peribronchial areas rather than colocated with macrophages in granulomas. T cells from TNF-/- mice retained proliferative and cytokine responses to purified protein derivative, and delayed-type hypersensitivity to purified protein derivative was demonstrable. Macrophages within the lungs of TNF-/- and wt mice showed similar levels of MHC class II and inducible nitric oxide synthase expression, and levels of serum nitrite were comparable. Thus, the enhanced susceptibility of TNF-/- is not compensated for by the presence of LT alpha, and the critical role of TNF is not in the activation of T cells and macrophages but in the local organization of granulomas.  (+info)

Fibroin allergy. IgE mediated hypersensitivity to silk suture materials. (7/2874)

Delayed-type hypersensitivity with granulomatous lesions to silk sutures is rather rare. Yet, braided silk sutures often act as a non-immunologic foreign-body and cause a granulomatous inflammatory reaction years after surgery. We report here a case of recurrent granulomas with remarkable infiltration of eosinophils that may have resulted from an IgE-mediated hypersensitivity reaction to silk fibroin, a component of the braided silk suture. Under normal circumstances exposure to fibroin is rather rare. Therefore, the present patient may have developed this reaction to the silk sutures used in a previous surgery.  (+info)

Protective effect of the type IV phosphodiesterase inhibitor rolipram in EAU: protection is independent of IL-10-inducing activity. (8/2874)

PURPOSE: Experimental autoimmune uveoretinitis (EAU) is a cell-mediated model of retinal autoimmunity that is negatively regulated by interleukin (IL)-10. The antidepressant drug rolipram, a type IV phosphodiesterase inhibitor, enhances IL-10 production by monocyte/macrophages. The effect of rolipram on induction of EAU and its associated immunologic responses was investigated. METHODS: Mice were challenged for EAU induction by immunization with the retinal antigen interphotoreceptor retinoid-binding protein (IRBP) or by adoptive transfer of uveitogenic T cells and were treated with rolipram. EAU severity and immunologic responses to IRBP were analyzed. In addition, the effect of rolipram added to the culture on antigen-driven responses of primed lymph node cells was tested. RESULTS: Rolipram treatment from days -1 to 7 after immunization (afferent phase) was not protective, but severity of EAU was reduced to 50% by treatment from days 8 to 16 after immunization or when EAU was induced by adoptive transfer (efferent phase). Antigen-specific proliferation and interferon (IFN)-gamma production ex vivo by lymph node cells of protected mice were not reduced. However, the addition of rolipram directly to the culture suppressed IRBP-driven proliferation and IFN-gamma production by primed lymph node cells. Freshly explanted lymph node cells of treated mice showed inhibition of IFN-gamma mRNA but no parallel enhancement of IL-10 mRNA by quantitative polymerase chain reaction. Rolipram inhibited EAU in IL-10 knockout mice equally well compared with controls and suppressed their primed lymph node cells in culture. CONCLUSIONS: Rolipram appears to inhibit the expansion and effector function of uveitogenic T cells, raising the possibility that it may be useful for treatment of established disease. Contrary to expectations based on in vitro studies, the protective effects in vivo appear to be independent of IL-10. The observation that suppression of antigen-specific responses is demonstrable only in the physical presence of the drug suggests that, in a clinical setting, continuous administration of rolipram might be needed to sustain its therapeutic effect.  (+info)

The delayed cutaneous hypersensitivity reaction to carcinoembryonic antigen (CEA) was tested in 84 patients with different diseases including large bowel adenocarcinoma and breast carcinoma, with or without metastasis, liver cirrhosis and inflammatory or degenerative diseases. Positive skin test to …
NON-SPECIFIC DELAYED-TYPE HYPERSENSITIVITY RESPONSE TO TREAT HERPES SIMPLEX VIRUS INFECTION - diagram, schematic, and image 01 ...
Purified proteins from Leishmania amastigotes-induced delayed type hypersensitivity reactions and remission of collagen-induced arthritis in animal models.: A t
IL-10 was originally described as Cytokine Synthesis Inhibitory Factor (CSIF) by virtue of its ability to inhibit cytokine production by Th1 clones. IL-10 shares over 80% sequence homology with the Epstein-Barr virus protein BCRFI. Upon binding to IL-10Rα and IL-10Rβ, the biological activities of IL-10 include inhibition of macrophage-mediated cytokine synthesis, suppression of the delayed type hypersensitivity response, and stimulation of the Th2 cell response, which results in elevated antibody production.. Click on the poster below to view the interactive version.. ...
In the United Kingdom the Medicines and Healthcare products Regulatory Agency commenced an annual monitoring regime for metal-on-metal hip replacement patients from May 2010.[13] Data which is shown in The Australian Orthopaedic Associations 2008 National Joint Replacement Registry, a record of nearly every hip implanted in that country over the previous 10 years, tracked 6,773 BHR (Birmingham Hip Resurfacing) Hips and found that less than one-third of one percent may have been revised due to the patients reaction to the metal component.[14] Other similar metal-on-metal designs have not fared as well, where some reports show 76% to 100% of the people with these metal-on-metal implants and have aseptic implant failures requiring revision also have evidence of histological inflammation accompanied by extensive lymphocyte infiltrates, characteristic of delayed type hypersensitivity responses. [15] It is not clear to what extent this phenomenon negatively affects orthopedic patients. However for ...
Migration of monocytic-phagocytic cells from guinea pigs immunized with complete Freunds adjuvant is regularly and specifically inhibited in tissue culture by 5 to 10µg/ml of PPD. Migration of leukocytes and spindle cells from such animals is inhibited by PPD less consistently and to a lesser degree.. Cutaneous hypersensitivity to PPD in these animals develops 5 days after adjuvant immunization; at this time migration of mononuclear cells from explants of lung and regional node is inhibited by addition of 10 µg/ml of PPD. Splenic cells become sensitive 2 to 3 weeks after immunization and hepatic macrophages become sensitive only several weeks later.. Cellular hypersensitivity to antigen, as measured by this technique, develops in guinea pigs infected with Histoplasma or immunized with emulsions of complete Freunds adjuvant and T4 bacteriophage, bovine γ-globulin, human γ-globulin, or picrylated guinea pig skin. The sensitivity is specific for the immunizing antigen.. Serum from immunized ...
We use cookies to ensure that we give you the best experience on our website. If you click Continue well assume that you are happy to receive all cookies and you wont see this message again. Click Find out more for information on how to change your cookie settings ...
An inflammatory response that develops 24 to 72 hours after exposure to an antigen that the immune system recognizes as foreign. This type of immune response involves mainly T cells rather than antibodies (which are made by B cells).
Delayed type hypersensitivity. On Day 1 of the study, mice were IV injected with washed sheep red blood cells (SRBC). On Day 6 of the study, mice were treated with either vehicle or Dexamethasone followed by injection of SRBCs into the paws. Injection of SRBCs into the paws of sensitized mice produced an allergic reaction as measured by swelling (paw thickness). Dexamethasone, a steroid anti-inflammatory, significantly reduced footpad swelling as measured using a microcaliper. Data are mean ± SEM; ***p,0.001 compared to vehicle (N=7-8).. The mouse DTH model is a test against an immunological inflammatory response. Animals that received vehicle treatment displayed an increased paw thickness compared to animals administered Dexamethasone, providing an immunological benefit. These data demonstrate a valid methodology for producing an allergic reaction in experimental animals and show that these animals are sensitive to pharmacological agents that are known to reduce allergic reactions.. ...
The immunological mechanisms driving delayed hypersensitivity reactions (HSRs) to drugs mediated by drug-reactive T lymphocytes are exemplified by several key examples and their human leukocyte antigen (HLA) associations: abacavir and HLA-B*57:01, carbamazepine and HLA-B*15:02, allo-purinol and HLA-B*58:01, and both amoxicillin-clavulanate and nevirapine with multiple class I and II alleles. For HLA-restricted drug HSRs, specific class I and/or II HLA alleles are necessary but not sufficient for tissue specificity and the clinical syndrome. Several models have been proposed to explain the immunopathogenesis of severe T cell-mediated drug HSRs, and our increased understanding of the risk factors and mechanisms involved in the development of these reactions will further the development of sensitive and specific strategies for preclinical screening that will lead to safer and more cost-effective drug design.. ...
SLE is which type of hypersensitivity reaction A. Type 1 hypersensitivity B. Type 2 hypersensitivity C. Type 3 hypersensitivity D. Type 4 hypersensitivity
SJS Etiology determined with any certainty is difficult, because the causes of various factors, although in general is often associated with immune response to the drug. Several factors cause SJS including: infections (viruses, fungi, bacteria, parasites), drugs (salicylates, sulfa, penicillin, etambutol, tegretol, tetracyclines, digitalis, contraceptives), food (chocolate), physical (cold air, sunlight, X-rays), etc. (polagen disease, malignancy, pregnancy). Pathogenesis SJS until now not yet clear, although often associated with type III hypersensitivity reactions (immune complex reaction) caused by a complex of soluble antigens or metabolites with IgM and IgG antibodies and hypersensitivity reactions slow (delayed-type hypersensitivity reactions, type IV) is a reaction mediated by specific T lymphocytes. ...
Previous studies in individuals immunized with gp160 suggest that a skin test response in immunized patients can be used as a surrogate marker for new proliferative and cytotoxic responses induced by vaccination.. Patients are stratified into three groups. Fifteen patients previously immunized with MicroGeneSys rgp160 antigen in ACTG 137 and not on antiretroviral therapy will receive intradermal injections of Immuno-AG rgp160 IIIB (vero cell expressed) in one arm, followed 1 week later by intradermal injections of MicroGeneSys rgp160 IIIB (baculovirus expressed) in the opposite arm (stratum 1). Forty patients who are not previously immunized with rgp160 will receive intradermal injections of Immuno-AG gp160 IIIB in one arm simultaneously with MicroGeneSys gp160 IIIB in the opposite arm; these patients are either not on antiretroviral therapy (stratum 2) or currently on antiretroviral therapy (stratum 3). All patients return 48 hours after each injection for skin test reading.. PER 4/5/95 ...
Synonyms for fungal hypersensitivity in Free Thesaurus. Antonyms for fungal hypersensitivity. 1 synonym for fungal: fungous. What are synonyms for fungal hypersensitivity?
Type IV hypersensitivity is often called delayed type hypersensitivity as the reaction takes two to three days to develop. Unlike the other types, it is not antibody mediated but rather is a type of cell-mediated response. CD8+ cytotoxic T cells and CD4+ helper T cells recognize antigen in a complex with either type 1 or 2 major histocompatibility complex. The antigen-presenting cells in this case are macrophages which secrete IL-12, which stimulates the proliferation of further CD4+ T cells. CD4+ T cells secrete IL-2 and interferon gamma, further inducing the release of other Type 1 cytokines, thus mediating the immune response. Activated CD8+ T cells destroy target cells on contact while activated macrophages produce hydrolytic enzymes and, on presentation with certain intracellular pathogens, transform into multinucleated giant cells. ...
Do You Have Hypersensitivity? Join friendly people sharing true stories in the I Have Hypersensitivity group. Find support forums, advice and chat with groups who share this life experience. Hypersensitivity anonymous support group with information o...
Simplified schematics helping to explain what are antibodies, what is hypersensitivity and how hypersensitivity relates to dog allergies.
Is Hypersensitivity a common side effect of Tylenol? View Hypersensitivity Tylenol side effect risks. Female, 55 years of age, weighting 150.0 lb, was diagnosed with sinus congestion, diabetes mellitus and took Tylenol .
Feeling Hypersensitivity while using Solupred? Hypersensitivity Causes, Patient Concerns and Latest Treatments and Solupred Reports and Side Effects.
Recently my therapist and I have been talking about and working on my hypersensitivity to criticism. I have always had some hypersensitivity to any kind of criticism or rebuke. As a kid, I was the one you could make cry by looking at me wrong or even gently scolding me. I still tear up over…
Recently my therapist and I have been talking about and working on my hypersensitivity to criticism. I have always had some hypersensitivity to any kind of criticism or rebuke. As a kid, I was the one you could make cry by looking at me wrong or even gently scolding me. I still tear up over…
Hypersensitivity reaction, Allergic or hypersensitivity conditions, Hypersensitivity response, Allergy - general information, Allergic reactions
The strategies of in vivo expansion of DC using Flt3L and immunization with wt human p53 using a sequence of Adv and plasmid DNA were examined in this study. We demonstrated the induction of an Ag-specific type 1 T-cell immune response in vitro as well as protection to tumor challenge with a murine tumor overexpressing p53. We observed a high DTH response to p53 peptides in mice immunized with sequential p53 genetic sequences (Adv-p53 and p53 plasmid DNA) and Flt3L; however, the DTH response did not differ from the group immunized with p53 genetic sequences alone. This suggests that the maximum DTH response might have been induced by p53 genetic priming alone and could not be augmented further by Flt3L. In contrast, we observed significant T cell proliferation in p53-immunized cohorts in response to 4T1/p53 cells. This T-cell proliferation was significantly augmented in cohorts immunized with p53 and Flt3L compared with the HBSS controls. The specificity of the T-cell proliferative response was ...
Perhaps a strongly antiviral IFN with weak cell-suppressive action would be more desirable in viral infections, whereas reversal of these properties might be better for tumor growth inhibition. 2h. Comparative Immunomodulatory Activities of Human IFNs. A number of immune functions, both in vitro and in vivo, have been shown to be altered by IFNs. Those manifestations of the immune system which can be either enhanced or depressed by IFNs include antibody formation, delayed-type hypersensitivity, allograft survival, natural killer, (NK)-cell activation, macrophage activation, and phagocytic activity (Stewart, 1979, 1981; DeMaeyer, 1983). This difference is the first measured distinguishing pharmacological property of the human IFNs. , 1976). , 1978). It was also found that human alpha IFN was 36 WILLIAM E. , 1979). , 1981; Niethammer and Treuner, 1982), and that it is ineffective in certain patients if given intramuscularly, whereas such patients do respond to intramuscularly injected alpha IFN ...
Allergic (including atopic) and other hypersensitivity disorders are inappropriate or exaggerated immune reactions to foreign antigens. Inappropriate immune reactions include those that are misdirected against intrinsic body components, leading to .
IgG and IgM based immunopathological reaction (reaction of hypersensitivity type II). = antibody-dependent. antibodies produced by the immune response bind to antigens on the patients own cell surfaces. intrinsic (self antigen, innately part of the patients cells). Slideshow 5264714 by charo
Hypersensitivity: Altered reactivity to an antigen, which can result in pathologic reactions upon subsequent exposure to that particular antigen.
25 yrs old Female asked about Skin hypersensitivity, 1 doctor answered this and 43 people found it useful. Get your query answered 24*7 only on | Practo Consult
Choi, YG, Curry, RJ, Park, BJ, Kim, KH, Heo, J and Hewak, DW (2005) Extreme hypersensitivity observed from H-6(15/2),-, F-6(11/2) transition of Dy3+ in inorganic noncrystalline solids ...
esophageal hypersensitivity occurs when the esophagus becomes very painful at the smallest change in pressure or exposure to acid. the cause of this sensitivity is unknown.
Learn Hypersensitivity facts using a simple interactive process (flashcard, matching, or multiple choice). Finally a format that helps you memorize and understand. Browse or search in thousands of pages or create your own page using a simple wizard. No signup required!
iMedPub is a new approach to scientific publishing. As an open service to scientists, it is driven by researchers for researchers, while serving the interests of the general public hypersensitivity | .
Type 4: Delayed/Cell-Mediated (mediated by T cells, T cells are slower to react than antibodies, so this reaction takes a couple days ...
heightened response in a body tissue to an antigen or foreign substance. The body normally responds to an antigen by producing specific antibodies against it. The antibodies impart immunity for any later exposure to that antigen. When exposure takes
I used to be worried that I wasnt colorblind. I didnt judge people based on the color of their skin, but I saw it. Not only was I aware, I was hypersensitive to race. I wanted to talk to black people about their experiences, their lives, their families. I tried not to. I tried to…
Tinnitis happens to be an hearing condition bringing about a ringing sensation in the ears leading to short-term tingling or maybe it can be lengthier. Buzzing in the ears is simply not a disease as it does not occur often; its a indication brought on be... Read , ...
Selected genes are highlighted in orange, bookmarked genes are green. - Chemical increases gene, - Chemical decreases gene, - Chemical increases and decreases gene simultaneosly, No arrows - gene doesnt interact with the chemical. - Gene should be increased/decreased most of the time and the chemical does it. - Gene should be increased/decreased most of the time but the chemical does the opposite. ...
Former South African president Nelson Mandela has been released from the hospital today after undergoing a laparoscopy, officials said.
Abstract Delayed hypersensitivity phenomena in cutaneous leishmaniasis of the guinea pig, caused by Leishmania enriettii, were investigated with an antigen prepared from promastigotes grown in culture. Cutaneous delayed-type hypersensitivity was shown to persist for several months after resolution of lesions. Two in vitro correlates of delayed hypersensitivity, blastoid transformation of peripheral blood lymphocytes and the inhibition of migration of peritoneal macrophages, were also positive. Macrophage inhibition persisted several months after resolution. These results suggest that immunity to this form of leishmaniasis is cell-mediated.
TY - JOUR. T1 - Tuberculosis in lung transplant recipients. AU - Bravo, Carlos. AU - Roldán, Juan. AU - Roman, Antonio. AU - DeGrada, Javier. AU - Majo, Joaquim. AU - Guerra, Javier. AU - Monforte, Víctor. AU - Vidal, Rafael. AU - Morell, Ferran. PY - 2005/1/15. Y1 - 2005/1/15. N2 - Background. Post-lung transplant infection is one of the leading causes of morbidity and mortality. The cause and incidence are similar in many series; however, infections such as Mycobacterium tuberculosis are influenced by the epidemiologic situation. The authors present a prospective and observational study to define the incidence, clinical presentation, and course of tuberculosis in a cohort of lung transplant patients at a single center in Spain. Methods. Between 1990 and 2002, cutaneous delayed-type hypersensitivity testing and pathologic and microbiologic study of explanted lungs were conducted in 187 lung transplant patients. Serial bronchoscopies with transbronchial biopsy and bronchioalveolar lavage were ...
The expression of delayed-type hypersensitivity in animals has been inhibited by a variety of anticoagulants, but direct evidence for activation of clotting in the evolution of these reactions has been lacking. Using the fluorescent antibody technique we here demonstrate that fibrin deposition is a prominent and consistent feature of both allergic contact dermatitis and classic delayed hypersensitivity skin reactions in man. Fib was detected in 55 of 58 delayed reactions studied at the peak of their intensity. The characteristic distribution of Fib-principally in the intervascular portions of the reticular dermis with sparing of vessels and their associated cuffs of mononuclear cells-is unusual and quite different from that described in antibody-mediated lesions in animals or man. Fib was found in vessel walls in only 2 of 94 biopsies studied. With a single exception, deposition of immunoglobulins and complement was not observed.. The pathogensis and significance of Fib deposition in these ...
For many HLA-associated ADRs the causative allele is yet to be identified. Given the strong LD in the MHC region, it is difficult to conclude that HLA alleles that show the strongest association with drug-induced adverse reactions are indeed the causative alleles. These associations encompass a diverse range of drugs and clinical manifestations, such as DILI or delayed type hypersensitivity reactions.. The complex interplay between HLA genes and haplotypes can only be replicated in systems where these haplotypes are present. Humanized animal models, in which specific human HLA alleles can be inserted into the mouse genome, have previously been used to model autoimmunity [46]. However, given the great complexity in the MHC region, where LD can confound the discovery of genetic associations and where there is a likely role for specific HLA haplotypes, it is unclear how successful this approach would be in studying ADRs to low molecular weight drugs in particular. Through the use of human ...
All chemotherapy agents can cause hypersensitivity reactions, which have limited the used of critical drugs in very sick patients for fear of inducing a more severe reaction and possibly death. The choice of an alternative chemotherapy regimen is often limited by tumor sensitivity and, because of the increasing number of cancer survivors, exposure to multiple courses of the same or similar chemotherapy agents. Increased exposures lead to sensitization and to hypersensitivity reactions in an increasing patient population. The need to offer first line therapy after cancer recurrence has spurred the clinical development of rapid desensitizations, which allow patients to be treated with medications to which they have presented hypersensitivity reactions. Desensitization protocols are available to treat hypersensitivity reactions to most chemotherapy agents including taxenes, platinums, doxorubicin, monoclonal antibodies and others, by gradual re-introduction of small amounts of drug antigens up to ...
Lymphocyte chemotaxis in inflammation. VIII. Demonstration of lymphocyte chemotactic lymphokines in PPD-induced delayed hypersensitivity skin reaction site in t
Costimulatory molecules, such as B7-1/2 and PD-L1/2 play an important role in the function of APC. The regulation of the surface levels of costimulatory molecules is one mechanism by which APC maintain the balance between tolerance and immunity. We examined the contributions of B7-1/2 and PD-L1/2 to the function of IL-10-treated, immunosuppressive DC as well as therapeutic exosomes derived from these DC. IL-10 treatment of DC significantly downregulated surface expression of MHC II, B7-1, B7-2, and decreased levels of MHC I and PD-L2. IL-10 treatment of DC resulted in a modified costimulatory profile of DC-secreted exosomes with a reduction in B7-1, PD-L1 and PD-L2. We further demonstrate that absence of B7-1 or B7-2 on donor DC results in a loss of ability of IL-10-treated DC and their exosomes to suppress the delayed-type hypersensitivity response, whereas IL-10-treated DC deficient in PD-L1/2 as well as their secreted exosomes retained the ability to suppress delayed-type hypersensitivity ...
During recent decades, the increased use of anticancer drugs has led to a consequent increase in the incidence of adverse effects. Hypersensitivity reactions to chemotherapeutic drugs, including monoclonal antibodies, can lead to the discontinuation of first-line therapies and can consequently affect the patients quality of life and life expectancy, as alternative agents may often be less effective, more toxic and/or more expensive. The exact mechanisms of these reactions are not well understood in most cases. However, they seem to involve different types of hypersensitivity. The IgEand non-IgE-mediated hypersensitivity reactions to anticancer drugs can be managed by rapid drug desensitization, enabling to sensitize patients to receive full treatment safely, thus representing an important advance in the patients treatment and prognosis.. ...
Coombs and Gel classified type IV hypersensitivity reaction (HR) as a delayed hypersensitivity reaction (DHR), which takes more than 12 hours to develop. Typically the maximal reaction time occurs between 48 to 72 hours. Antibodies do not mediate DHR; it is mediated by T cells that cause an inflammatory reaction to either exogenous or autoantigens. This HR to exogenous antigens involves T cells and also antigen-presenting cells (APC) such as macrophages and dendritic cells, all produce cytokines that stimulate a local inflammatory response in a sensitized individual. The DHR to autoantigens can be seen in type 1 diabetes mellitus, which is an autoimmune disease that results from autoimmune cell-mediated destruction of insulin-secreting pancreatic beta cells. DHR cannot be transferred from an animal to another by means of antibodies or serum. However, it can be transferred by T cells, particularly CD4 Th1 cells, but it is progressively lost in individuals with HIV/AIDS. Antigen-presenting cells ...
Delayed hypersensitivity reactions are inflammatory reactions initiated by mononuclear leukocytes. The term delayed is used to differentiate a secondary cellular response, which appears 48-72 hours after antigen exposure, from an immediate hypersensitivity response, which generally appears within 12 minutes of an antigen challenge.
Learn Hypersensitivity Type III - Hypersensitivity Reactions - Pathology - Picmonic for Medicine faster and easier with Picmonics unforgettable videos, stories, and quizzes! Picmonic is research proven to increase your memory retention and test scores. Start learning today for free!
Best hypersensitivity vasculitis specialist in New Delhi. Get help from medical experts to select the right hypersensitivity vasculitis doctor from top hospitals in New Delhi. View profile, fees, educational qualification, feedback and reviews of top hypersensitivity vasculitis specialists near you. Get upto 25% discount on OPD fees of hypersensitivity vasculitis doctors at hospitals near you.
Hereditary Factors:, Life-History Effects:, Serology: Antigen,, Congenic Resistant Lines: B10.A, B10.A (2R), B10.A (5R), B10.A (4R), Genes: H-2 - Histocompatibility-2, Strains: BALB/C, CBA/CA, C57BL/6, C57BL/10, DBA/2 (212). ...
The Update Classification of Allergy and Hypersensitivity Diseases The classification of allergic and hypersensitivity diseases was established by the European Academy of Allergy and Clinical Immunology (EAACI) and the World Allergy Organization (WAO) in 2004 (1). The definitions and concepts of allergic and hypersensitivity conditions beyond the allergy community have often created misunderstanding (2). For…
A hypersensitivity reaction: when the immune system attacks foreign matter entering your body. Autoimmune diseases are hypersensitivity reactions.
Type IV hypersensitivity Reaction result from inappropriate T-cell activation, and take much time to develop its action for this reason it is also called..
Hypersensitivity reaction information including symptoms, diagnosis, misdiagnosis, treatment, causes, patient stories, videos, forums, prevention, and prognosis.
Chronic inflammation is induced by OXA sensitization and multiple challenges. It is characterized by Th1 and Th2 inflammatory reaction observed as increased cytokine concentration in ear tissue and IgE concentration in serum. Anti-inflammatory activity of test compounds is evaluated throughout the study (main read-outs) , while ear and other selected tissues are collected at the end of the study to be subsequently analyzed or sent to the sponsor, as requested.. ...
DNaseI hypersensitivity - posted in DNA Methylation and Epigenetics: Hi, Does anybody know if you can look at DNaseI hypersensitivity in frozen PBMCs or do the PBMCs need to be from fresh blood. Many thanks.
Ferrihydrite is a puzzling nanosized mineral with a 50-year-old history of debates over its structure, composition and formation. Here we directly identify populations of the reactive hydroxyl groups driving the high catalytic reactivity of this mineral in nature.
Semantic Scholar extracted view of Studies on the cells responsible for the delayed type of hypersensitivity with special reference to lymphocytes. by Masahiko Fukase
The AAAAI explains Hypersensitivity Vasculitis is an intense immune reaction to a drug, infection or other substance that causes inflammation and damage to blood vessels.
Hypersensitivity to abacavir is immunologically mediated, driven by conventional MHC-I antigen presentation and activation of HLA-B*5701.{ref4}{ref5} Activation of HLA-B*5701 restricted CD8+ T cells r... more
Extreme hypersensitivity to cold can be induced in the rat by a single subcutaneous injection of carrageenin. In animals so treated, exposure to cold induces necrotizing thrombohemorrhagic lesions in the nose, paws, and tail, accompanied by renal lesions resembling those of the generalized Sanarelli-Shwartzman phenomenon. The same treatment elicits hemorrhagic necroses of transplants of Murphy lymphosarcomas in rats. ...
पाठ क्रिएटिभ कमन्स एट्रिब्युसन/सेयर-अलाइक लाइसेन्सअन्तर्गत उपलब्ध छ; अतिरिक्त सर्तहरू लागू हुन सक्छन्। अधिक जानकारीको लागि उपयोगका सर्तहरू हेर्नुहोला ...
Imaging the world, a situation, or a problem from someone elses point of view is difficult. Yet many us of imagine that we are rather good at it. I thought I had a rather good idea what it would be like to be hypersensitive. This condition is linked to autism, which I have read about…
We offer clinical cancer updates, treatment guidance, and research news to the oncology nursing community. Visit us often for drug therapy testing results, patient care information and more. Download our FREE app today.
If you find that you are getting more sensitive to what goes on in your life and in the world, you sometimes feel overwhelmed to the point you dont recognize yourself and wish you had stayed in bed, you are not alone!
The medical information on this website is provided as is without any representations or warranties, express or implied. GoPharmD makes no representations or warranties in relation to the medical information on this website.. GoPharmD does not warrant that:. ...
Cell-mediated immunity is one of the two types of adoptive immune system in the human body. Its generally used to fight microbes...
Delayed type 4 allergic hypersensitivity reactions including maculopapular exanthema, erythematous rash, urticarial eruption, ... Ortega, NR; Barranco, P; López Serrano, C; Romualdo, L; Mora, C (February 1996). "Delayed cell-mediated hypersensitivity to ... Blanco, R; Díez-Gómez, ML; Gala, G; Quirce, S (November 1997). "Delayed hypersensitivity to tetrazepam". Allergy. 52 (11): 1146 ... These hypersensitivity reactions to tetrazepam share no cross-reactivity with other benzodiazepines. Tetrazepam is used ...
Winkelmann RK, Harris RB (1979). "Lichenoid delayed hypersensitivity reactions in tattoos". J Cutan Pathol. 6 (1): 59-65. doi: ... Delayed abrupt chronic reactions, such as eczematous dermatitis, are known to manifest themselves from months to as many as ...
"Hypersensitivity Reactions, Delayed". EMedicine. Rothenberg ME; Rothenberg, Marc E. (1998). "Eosinophilia". N. Engl. J. Med. ... should not be confused with delayed hypersensitivity Type IV allergic reaction (which takes 48-72 hours to develop and is ...
Kobayashi, Kazuo; Kaneda, Kenji; Kasama, Tsuyoshi (15 May 2001). "Immunopathogenesis of delayed-type hypersensitivity". ... and hypersensitivity-type granulomas in mice". Infection and Immunity. 69 (2): 810-5. doi:10.1128/IAI.69.2.810-815.2001. PMC ... indicating that they can be foreign-body-type or hypersensitivity-type. This means cord factor can stimulate a response by ...
"Cytotoxicity mediated by soluble antigen and lymphocytes in delayed hypersensitivity. 3. Analysis of mechanism". J. Exp. Med. ...
Delayed contact hypersensitivity in the guinea pig. Archives of Dermatology, 91, 171 Ritz, H. L.; Buehler, E. V. (1980). " ...
Katz SI, Parker D, Turk JL (October 1974). "B-cell suppression of delayed hypersensitivity reactions". Nature. 251 (5475): 550- ... This was shown for example in model of EAE, CIA or contact hypersensitivity. Likewise, regulatory B cell subsets have also been ...
Evidence does not support a benefit in delayed-onset muscle soreness. It may be useful for muscle pain and injuries. Similarly ... There is tentative evidence for dentin hypersensitivity. It does not appear to be useful for orthodontic pain LLLT might be ... "Effect of low-level phototherapy on delayed onset muscle soreness: a systematic review and meta-analysis". Lasers in Medical ... "Lasers for the treatment of dentin hypersensitivity: a meta-analysis". Journal of Dental Research. 92 (6): 492-499. doi:10.1177 ...
Characterization of a protein that causes immediate but not delayed hypersensitivity". Journal of Immunology 147 136, 96-101 ( ... Nail disease Allergy Hypersensitivity Occupational asthma Ward GW, Karlsson G, Rose G, Platts-Mills TAE (1989). "Trichophyton ... Hypersensitivity reactions are the most probable disposition for healthcare workers inhaling nail dust, although more serious ... In 1975, two female chiropodists were diagnosed with allergic hypersensitivity to nail dust Since that time, there have been a ...
It typically results from a delayed hypersensitivity reaction. Eye floaters and loss of accommodation are among the earliest ... specifically a delayed hypersensitivity to melanin-containing structures from the outer segments of the photoreceptor layer of ... skin tests with soluble extracts of human or bovine uveal tissue are said to elicit delayed hypersensitivity responses in these ...
December 2011). "The role for decorin in delayed-type hypersensitivity". Journal of Immunology. 187 (11): 6108-19. doi:10.4049/ ...
"Involvement of interleukin-3 in delayed-type hypersensitivity". Blood 92:778-783. "Richard C. Mulligan, Ph.D. , HMS Department ...
Langhans giant cell occurs frequently in delayed hypersensitivity. Symptoms may include Fever Weight loss Fatigue Loss of ... These symptoms are often misinterpreted leading to a delay in treatment. If left untreated, this disease can result in ...
It tests for delayed food reactions.[44][45][46]. *Blood testing is another way to test for allergies; however, it poses the ... Hypersensitivities are categorized according to the parts of the immune system that are attacked and the amount of time it ... Another reason steroids should not be used is the delay in reducing inflammation. Steroids can also be taken orally or through ... In the early stages of allergy, a type I hypersensitivity reaction against an allergen, encountered for the first time, causes ...
The MELISA test measures type-IV delayed hypersensitivity reaction. Type-IV reactions are mediated by T-lymphocytes (or memory ... MELISA was further developed to help to assess the impact of hypersensitivity to metals used in dentistry. Hypersensitivity to ... reported worsening of symptoms Type IV hypersensitivity to metals is common, particularly to nickel, however hypersensitivity ... Metal hypersensitivity is not widely recognized by researchers as an accepted cause of CFS or multiple sclerosis.[citation ...
"eMedicine - Hypersensitivity Reactions, Delayed : Article by Walter Duane Hinshaw". Archived from the original on 2008-09-15. ... Morell F, Levy G, Orriols R, Ferrer J, De Gracia J, Sampol G (April 2002). "Delayed cutaneous hypersensitivity tests and ...
A wheal response occurring at the injection site within 20 minutes is considered positive (immediate hypersensitivity). Delayed ... Being a type I hypersensitivity reaction, anaphylactic reaction tray must be kept ready before carrying out the test. ... hypersensitivity reactions usually read after 18-24 hours. The test is positive in about 90% of cases of hydatid disease ...
The reaction occurs via a delayed-type hypersensitivity mechanism. This reaction occurs within 48 hours of injection of ... In contrast, the Mitsuda reaction (delayed granulomatous lesion) occurs 3-4 weeks after injection of lepromin and is only seen ...
Type 4 hypersensitivity, also known as delayed type hypersensitivity, are caused via the over-stimulation of immune cells, ... Th1 overactivation against autoantigens will cause Type 4 delayed-type hypersensitivity. Tuberculin reaction or Type 1 diabetes ... Hypersensitivity reactions can be divided into four types: *Type 1 hypersensitivity includes common immune disorders such as ... Hypersensitivity[edit]. The immune system must achieve a balance of sensitivity in order to respond to foreign antigens without ...
Ruddle NH, Waksman BH (December 1968). "Cytotoxicity mediated by soluble antigen and lymphocytes in delayed hypersensitivity. 3 ...
Morell F, Levy G, Orriols R, Ferrer J, De Gracia J, Sampol G (April 2002). "Delayed cutaneous hypersensitivity tests and ...
Hypersensitivities are categorized according to the parts of the immune system that are attacked and the amount of time it ... delayed cell-mediated. The consequent pathophysiology of allergic responses can be divided into two time periods: The first is ... Shellfish allergy is an immune hypersensitivity to proteins found in shellfish. Symptoms can be either rapid or gradual in ... The four types of hypersensitivity reaction are: type 1, immediate IgE-mediated; type 2, cytotoxic; type 3, immune complex- ...
Such infants often display oral-tactile hypersensitivity (also known as oral aversion). Physical findings: hypoxemia; ... delayed growth & development; cor pulmonale; CXR shows with hyperinflation, low diaphragm, atelectasis, cystic changes. ...
April 2009). "Role of the heparan sulfate proteoglycan syndecan-1 (CD138) in delayed-type hypersensitivity". Journal of ... Elenius V, Götte M, Reizes O, Elenius K, Bernfield M (October 2004). "Inhibition by the soluble syndecan-1 ectodomains delays ... "Syndecan-1 regulates dendritic cell migration in cutaneous hypersensitivity to haptens". Experimental Dermatology. 26 (11): ...
Ishizaki H, Nakamura Y, Kariya H, Iwatsu T, Wheat R (1976). "Delayed hypersensitivity cross-reactions between Sporothrix ...
"Role of Delayed Cellular Hypersensitivity and Adhesion Molecules in Amoxicillin-Induced Morbilliform Rashes". Archives of ...
Fisher, A. A. (1 October 1975). "Allergic paraben and benzyl alcohol hypersensitivity relationship of the "delayed" and " ...
Type 4 hypersensitivity, also known as delayed type hypersensitivity, are caused via the over-stimulation of immune cells, ... Th1 overactivation against autoantigens will cause Type IV or delayed-type hypersensitivity reaction. Tuberculin reaction or ... Hypersensitivity is believed to be the cause of allergy and some auto-immune disease. Hypersensitivity reactions can be divided ... Other cellular hypersensitivities include cytotoxic T cell mediated auto-immune disease, and a similar phenomenon; transplant ...
... is probably a delayed hypersensitivity reaction to a variety of antigens. Although circulating immune ...
A delayed type hypersensitivity reaction of cell mediated immunity has been suggested in the pathogenesis of ...
Treatment delay. Alternative medicine may discourage people from getting the best possible treatment.[169] Those having ... Electromagnetic hypersensitivity. *Heavy legs. *Leaky gut syndrome. *Multiple chemical sensitivity. *Wilson's temperature ... failure to use or delay in using conventional science-based medicine has caused deaths.[171][172] ...
Grapefruit juice may delay the absorption of levothyroxine, but based on a study of 10 healthy people aged 20-30 (8 men, 2 ... Levothyroxine is contraindicated in people with hypersensitivity to levothyroxine sodium or any component of the formulation, ...
Indirect risks of chiropractic involve delayed or missed diagnoses through consulting a chiropractor.[4] ... Electromagnetic hypersensitivity. *Electronic voice phenomenon. *Feng shui. *Flat Earth theory. *Germ theory denialism ...
No cure for COPD is known, but the symptoms are treatable and its progression can be delayed.[88] People with COPD can ... Hypersensitivity pneumonitis Bagassosis. Bird fancier's lung. Farmer's lung. Lycoperdonosis. Other. *ARDS. *Combined pulmonary ... it can reduce the rate of worsening lung function and delay the onset of disability and death.[92] Often, several attempts are ...
... skin tests for delayed-type hypersensitivity, cell responses to mitogens and allogeneic cells, cytokine production by cells ... and signs that lead to the diagnosis of an immunodeficiency include recurrent or persistent infections or developmental delay ...
Wound healing is delayed. For this reason elective surgery, waxing of hair, tattooing, tattoo removal, piercings, dermabrasion ...
Lesions to this region impair the use of distal but not proximal landmarks during navigation and produces a delay-dependent ... Adult rats who with NVHL show typical indicators of schizophrenia such as hypersensitivity to psychostimulants, reduced social ... Lesions to this area also cause deficits on delayed nonmatching-to-positions tasks and impairments in the acquisition of ... while NMDA receptors in the CA1 are required in the acquisition and retrieval of memory after a delay, as well as in the ...
"DNA ligase IV mutations identified in patients exhibiting developmental delay and immunodeficiency". Mol. Cell 8 (6): 1175-85. ... "Mutations in the DNA ligase I gene of an individual with immunodeficiencies and cellular hypersensitivity to DNA-damaging ...
Osmophobia - hypersensitivity to smells causing aversion to odors. *Phonophobia - hypersensitivity to sound causing aversion to ... and in medicine to describe hypersensitivity to a stimulus, usually sensory (e.g. photophobia). In common usage, they also form ...
Type 4 hypersensitivity is often called delayed type hypersensitivity as the reaction takes several days to develop. Unlike the ... Type V hypersensitivity. References[edit]. *^ a b c d e f g Kumar, Vinay; Abbas, Abul K.; Aster, Jon C. (2012-05-01). Robbins ... "Hypersensitivity reactions". www.microbiologybook.org. Retrieved 2016-05-29.. *^ McDonough, K.; Kress, Y.; Bloom, B. R. (July ... "Hypersensitivity reactions". www.microbiologybook.org. University of South Carolina School of Medicine - Microbiology and ...
If the episode occurs at all after the consumption of these foods, its onset may be delayed overnight or by some hours, making ...
Afraid of going back to the deadly environment there, Hank delayed his transfer.) Gomez has been Hank's right-hand man in the " ... After Chuck steps away from the firm due to his claim of electromagnetic hypersensitivity, Howard covers for him trying to ... Chuck believes he suffers from electromagnetic hypersensitivity, an unusual affliction caused by mysterious circumstances, ... as Chuck believes he suffers from electromagnetic hypersensitivity. Jimmy later hires Huell to serve as a bodyguard while Jimmy ...
Hypersensitivity reactionsEdit. ALOX5 contributes to non-allergic reactions of the respiratory system and skin such as aspirin- ... early versus delayed) at which observations are made; and, very likely, various other factors. ... LTC4, LTD4, and LTE4 contribute to allergic airways reactions such as asthma, certain non-allergic hypersensitivity airways ... it may also contribute to hypersensitivity responses of the respiratory system to cold air and possibly even alcohol beverages ...
... delaying or preventing the onset of nonobese diabetes. This is particularly true of the Shirota strain of L. casei (LcS). The ... Hypersensitivity and autoimmune diseases (279.5-6). Type I/allergy/atopy. (IgE). Foreign. *Atopic eczema ...
Smoked meat for example has phenols and other chemicals that delay spoilage. The preservation of foods has evolved greatly over ... Benzoate was shown in a study to cause hypersensitivity in some asthma sufferers. This has caused reexamination of natural ...
water-balance/acid-base: Allopurinol hypersensitivity syndrome. *pulmonary: Leukotriene receptor antagonist-associated Churg- ...
Type IV allergy, also known as allergic contact dermatitis, involves a delayed skin rash that is similar to poison ivy with ... The most serious and rare form of latex allergy, Type I hypersensitivity can cause an immediate and potentially life- ... Böhm, Ingrid (2010). "Latex allergy in patients suspected for contrast medium hypersensitivity: A neglected differential ...
"Cytotoxicity mediated by soluble antigen and lymphocytes in delayed hypersensitivity. 3. Analysis of mechanism". J. Exp. Med. ...
"Early delayed radiation-induced myelopathy" can manifest from six weeks to six months after treatment; the usual symptom is a ... and hypersensitivity to cold, beginning in the hands and feet and sometimes progressing to the arms and legs. Chemotherapy ... "Late delayed radiation-induced myelopathy" may occur six months to ten years after treatment. The typical presentation is Brown ...
... intestinal tracts on delayed images. In Strongyloidiasis barium studies show intestinal wall oedema, thickening of intestinal ... Hypersensitivity and allergic reactions are rare but some additives contained in barium preparations may induce immune ...
The removal of amalgam fillings is not recommended for reasons other than a true hypersensitivity to mercury.[51] Mercury ... it is advisable to delay or avoid dealing with amalgam fillings in pregnant patients. ... An l case of immediate hypersensitivity reaction associated with an amalgam restoration". British Dental Journal, British ... "An unusual case of immediate hypersensitivity reaction associated with an amalgam restoration, ...
editor, Mariana C. Castells, (2010-12-09). Anaphylaxis and hypersensitivity reactions. New York: Humana Press. p. 187. ISBN ... CT of the head should be avoided for adults and delayed pending clinical observation in the emergency department for children.[ ...
In March 2016, Teva's ANDA for a generic EpiPen, which had already faced several delays, was rejected by the FDA.[78] ... The intramuscular route is preferred over subcutaneous administration because the latter may have delayed absorption.[4][5] ...
Type I RPG/Type II hypersensitivity. *Goodpasture's syndrome. Type II RPG/Type III hypersensitivity. *Post-streptococcal ... general: Hypogonadism (Delayed puberty). *Hypergonadism *Precocious puberty. *Hypoandrogenism. *Hypoestrogenism. * ...
... hypersensitivity to external stimuli and difficulties with thinking, concentration and memory".[81] The U.N. Special Rapporteur ... inaccessibility of immigrant detention centers pose a problem as those who can afford counsel risk having meetings be delayed ...
Schlienger, Raymond G.; Shear, Neil H. (1998). "Antiepileptic drug hypersensitivity syndrome". Epilepsia. 39 (Suppl 7): S3-7. ... morphological characteristics-enlarged red blood cells with abnormally high nuclear-cytoplasmic ratios resulting from delayed ... Primidone is one of the anticonvulsants associated with anticonvulsant hypersensitivity syndrome, others being carbamazepine, ...
The term delayed is used to differentiate a secondary cellular response, which appears 48-72 hours after antigen exposure, from ... an immediate hypersensitivity response, which generally appears within 12 minutes of an antigen challenge. ... Delayed hypersensitivity reactions are inflammatory reactions initiated by mononuclear leukocytes. ... encoded search term (Delayed%20Hypersensitivity%20Reactions) and Delayed Hypersensitivity Reactions What to Read Next on ...
Failure of delayed hypersensitivity skin testing to predict postoperative sepsis and mortality.. Br Med J (Clin Res Ed) 1982; ... Failure of delayed hypersensitivity skin testing to predict postoperative sepsis and mortality. Br Med J (Clin Res Ed) 1982; ... Delayed hypersensitivity skin reactions to a battery of recall antigens, haemoglobin and albumin concentrations, arm-muscle ... These results suggest that the routine use of delayed hypersensitivity skin testing in the preoperative assessment of surgical ...
delayed-type hypersensitivity response listen (...HY-per-SEN-sih-TIH-vih-tee reh-SPONTS) An inflammatory response that develops ...
Delayed-type hypersensitivity (DTH) is a useful approach for evaluating cell-mediated immune responses associated with Th1 ... Delayed-type hypersensitivity (DTH) is a useful approach for evaluating cell-mediated immune responses associated with Th1 ... Allen I.C. (2013) Delayed-Type Hypersensitivity Models in Mice. In: Allen I. (eds) Mouse Models of Innate Immunity. Methods in ... delayed-type hypersensitivity (DTH) model: role for p38 kinase. Int Immunopharmacol 9:1218-1227PubMedCrossRefGoogle Scholar ...
The delayed cutaneous hypersensitivity reaction to carcinoembryonic antigen (CEA) was tested in 84 patients with different ... Delayed cutaneous hypersensitivity reaction to carcinoembryonic antigen in cancer patients Tumori. 1982 Dec 31;68(6):473-5. ... Similar delayed cutaneous hypersensitivity reactions were found to various amount of CEA ranging from 0.5 to 25 micrograms. No ... The delayed cutaneous hypersensitivity reaction to carcinoembryonic antigen (CEA) was tested in 84 patients with different ...
TRANSFER OF DELAYED HYPERSENSITIVITY TO DIPHTHERIA TOXIN IN MAN. H. S. Lawrence, A. M. Pappenheimer ... Simultaneous transfer of delayed hypersensitivity to diphtheria toxin and to tuberculin has been accomplished in eight ... Two of these sensitized individuals showed severe delayed skin reactions specifically directed against diphtheria toxin (or ...
Delayed Cutaneous Hypersensitivity to Oxazolone in Mice with Tumors. George R. Hemsworth, John S. Wolff III, Allen R. Kraska ... Delayed Cutaneous Hypersensitivity to Oxazolone in Mice with Tumors. George R. Hemsworth, John S. Wolff III, Allen R. Kraska ... Delayed Cutaneous Hypersensitivity to Oxazolone in Mice with Tumors. George R. Hemsworth, John S. Wolff III, Allen R. Kraska ... Delayed Cutaneous Hypersensitivity to Oxazolone in Mice with Tumors Message Subject (Your Name) has forwarded a page to you ...
... but negative delayed skin reactions. Subjects selected were paired as closely as possible in sex, age, quantitative S. mansoni ... Abstract Serological responses and clinical states of 15 subjects with overt Schistosoma mansoni infection and delayed ... hypersensitivity (DHS) to adult worm antigen were compared with responses in 15 subjects with overt infection, ... Delayed Hypersensitivity in Ugandan Schistosomiasis Mansoni III. Examination of Serological Responses and Clinical States* * ...
... the phenomenon of delayed hypersensitivity is characterized briefly, and, based on recent reports, its apparent demonstration ... In this review, the phenomenon of delayed hypersensitivity is characterized briefly, and, based on recent reports, its apparent ...
Activity in Vitro of Lymphocytes and Macrophages in Delayed Hypersensitivity. S. B. Salvin, Stewart Sell and Jane Nishio ... Activity in Vitro of Lymphocytes and Macrophages in Delayed Hypersensitivity Message Subject (Your Name) has forwarded a page ... in vitro observations provided direct evidence of immunologically induced cellular interactions in delayed hypersensitivity ...
... can evoke type IV delayed hypersensitivity reactions, according to an article published online April 27 in BMJ Case Reports. ... HealthDay)-Black henna, used in temporary skin tattoos, can evoke type IV delayed hypersensitivity reactions, according to an ... The patient was diagnosed with type IV delayed hypersensitivity to black henna with surrounding cellulitis. The patient was ... Citation: Temporary skin tattoos can evoke delayed hypersensitivity (2016, May 13) retrieved 4 December 2020 from https:// ...
CCR6-deficient mice have impaired leukocyte homeostasis and altered contact hypersensitivity and delayed-type hypersensitivity ... CCR6-deficient mice have impaired leukocyte homeostasis and altered contact hypersensitivity and delayed-type hypersensitivity ... Conversely, in a delayed-type hypersensitivity (DTH) model induced with allogeneic splenocytes, CCR6-/- mice developed no ... In 2,4-dinitrofluorobenzene-induced contact hypersensitivity (CHS) studies, CCR6-/- mice developed more severe and more ...
Demonstration in vitro of delayed hypersensitivity in experimental allergic orchitis in guinea-pigs. Download Prime PubMed App ... AnimalsAntibodiesAscitic FluidCell Migration InhibitionCulture TechniquesFreunds AdjuvantGuinea PigsHypersensitivity, Delayed ... Demonstration in Vitro of Delayed Hypersensitivity in Experimental Allergic Orchitis in Guinea-pigs. J Reprod Fertil. 1971;26(2 ... Demonstration in vitro of delayed hypersensitivity in experimental allergic orchitis in guinea-pigs. J Reprod Fertil. 1971;26(2 ...
Compromised Humoral and Delayed-Type Hypersensitivity Responses in IL-23-Deficient Mice. Nico Ghilardi, Noelyn Kljavin, Qi Chen ... In addition, delayed type hypersensitivity responses are strongly impaired in the absence of IL-23, indicating a defect at the ... For example, it was shown that IL-12p40−/− mice have reduced NK cell responses, reduced delayed-type hypersensitivity (DTH)3 ... Compromised Humoral and Delayed-Type Hypersensitivity Responses in IL-23-Deficient Mice ...
THE RÔLE OF THE "WAX" OF THE TUBERCLE BACILLUS IN ESTABLISHING DELAYED HYPERSENSITIVITY. Sidney Raffel, John E. Forney ... THE RÔLE OF THE "WAX" OF THE TUBERCLE BACILLUS IN ESTABLISHING DELAYED HYPERSENSITIVITY ... which has been previously demonstrated as an essential element in causing delayed tuberculin hypersensitivity in response to ... injection of this compound with wax intraperitoneally into guinea pigs results in a marked delayed cutaneous hypersensitivity, ...
Beeton, C., Chandy, K. G. Induction and Monitoring of Active Delayed Type Hypersensitivity (DTH) in Rats. J. Vis. Exp. (6), ...
A Phase I/II Study of Delayed-Type Hypersensitivity (DTH) Reactions to Intradermal HIV Envelope Antigen. The safety and ... Delayed-type hypersensitivity to recombinant HIV envelope glycoprotein (rgp160) after immunization with homologous antigen. J ... To determine the frequency of delayed-type hypersensitivity (DTH) reactions in HIV-positive patients to two doses of two ... A Phase I/II Study of Delayed-Type Hypersensitivity (DTH) Reactions to Intradermal HIV Envelope Antigen. ...
Delayed" by people in this website by year, and whether "Hypersensitivity, Delayed" was a major or minor topic of these ... "Hypersensitivity, Delayed" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical ... Below are the most recent publications written about "Hypersensitivity, Delayed" by people in Profiles. ... Below are MeSH descriptors whose meaning is more general than "Hypersensitivity, Delayed". ...
Persistence and Boosting of Bacille Calmette-Guérin-Induced Delayed-Type Hypersensitivity Daniel F. Hoft, MD, PhD; Jan M. ... Persistence and Boosting of Bacille Calmette-Guérin-Induced Delayed-Type Hypersensitivity. Ann Intern Med. 1999;131:32-36. doi ... In addition, BCG-related persistence and boosting of delayed-type hypersensitivity responses correlate with other potential ... Persistent and boosted delayed-type hypersensitivity correlated with mycobacterial-specific lymphoproliferation and interferon- ...
Passive Transfer of Delayed Hypersensitivity to Blastomyces dermatitidis Between Mice. James J. Scillian, George C. Cozad, ... Passive Transfer of Delayed Hypersensitivity to Blastomyces dermatitidis Between Mice. James J. Scillian, George C. Cozad, ... Passive Transfer of Delayed Hypersensitivity to Blastomyces dermatitidis Between Mice. James J. Scillian, George C. Cozad, ... Passive Transfer of Delayed Hypersensitivity to Blastomyces dermatitidis Between Mice Message Subject (Your Name) has forwarded ...
Tumor-specific delayed hypersensitivity was not transferred when: (a) RNA extracts were from liver, muscle, or kidney of tumor- ... Tumor-specific delayed hypersensitivity was demonstrated by the inhibition of migration from capillary tubes of the RNA-treated ... Tumor-specific delayed hypersensitivity was transferred to peritoneal exudate cells obtained from unimmunized strain 2 guinea ... Transfer of Tumor-specific Delayed Hypersensitivity in Vitro to Normal Guinea Pig Peritoneal Exudate Cells Using RNA Extracts ...
Regarding my yesterdays question about antibiotic delayed hypersensitivity reactions: is it possible to get SJS - Answered by ... Regarding my yesterdays question about antibiotic delayed hypersensitivity reactions: is it possible to get SJS syndrome from ... In addition to many igE mediated hypersensitivities (a decade of chronic recurrent urticaria), Ive had many weird skin skin ...
Delayed hypersensitivity and acquired cellular resistance in guinea pigs infected with Listeria monocytogenes.. B L Halliburton ... Delayed hypersensitivity and acquired cellular resistance in guinea pigs infected with Listeria monocytogenes. ... Delayed hypersensitivity and acquired cellular resistance in guinea pigs infected with Listeria monocytogenes. ... Delayed hypersensitivity and acquired cellular resistance in guinea pigs infected with Listeria monocytogenes. ...
Delayed-type hypersensitivity (DTH) test responsiveness is associated with HIV disease progression; however it is unknown ... Delayed-type hypersensitivity and hepatitis B vaccine responses, in vivo markers of cellular and humoral immune function, and ... Background: Delayed-type hypersensitivity (DTH) test responsiveness is associated with HIV disease progression; however it is ...
A general method for induction of the delayed hypersensitive state directed against single protein antigens is described. The ... DELAYED HYPERSENSITIVITY : II. INDUCTION OF HYPERSENSITIVITY IN GUINEA PIGS BY MEANS OF ANTIGEN-ANTIBODY COMPLEXES Jonathan W. ... Jonathan W. Uhr, S. B. Salvin, A. M. Pappenheimer; DELAYED HYPERSENSITIVITY : II. INDUCTION OF HYPERSENSITIVITY IN GUINEA PIGS ... Characteristics of the "delayed" as opposed to the "immediate" hypersensitive states in the guinea pig are described and ...
The relationship of delayed hypersensitivity to acquired cellular resistance. J. Exp. Med. 129:973-992. ... Transfer of both protection and delayed-type hypersensitivity against live Listeria is mediated by the CD8+ T cell subset: a ... Enhanced antigen-specific delayed-type hypersensitivity and immunoglobulin G2b responses after oral administration of viable ... Expression of systemic protection and delayed-type hypersensitivity to Listeria monocytogenes is mediated by different T-cell ...
Comparison of an in vitro tuberculosis interferon-gamma assay with delayed-type hypersensitivity testing for detection of ... Comparison of an in vitro tuberculosis interferon-gamma assay with delayed-type hypersensitivity testing for detection of ... Comparison of an in vitro tuberculosis interferon-gamma assay with delayed-type hypersensitivity testing for detection of ... Comparison of an in vitro tuberculosis interferon-gamma assay with delayed-type hypersensitivity testing for detection of ...
Humoral immunity and delayed-type hypersensitivity in healthy subjects treated for 30 days with MK-7123, a selective CXCR2 ... in the adaptive immune system and delayed-type hypersensitivity (DTH) in healthy subjects (ages 34-65 years) dosed once daily ...
Investigation of the role of delayed-type-hypersensitivity responses to myelin in the pathogenesis of Theilers virus-induced ... Delayed-type hypersensitivity responses to myelin were examined in both symptomatic and asymptomatic mice at different times ...
The induction of delayed hypersensitivity in guinea pigs by viable and killed nocardia organism - Page 24 ... The induction of delayed hypersensitivity in guinea pigs by viable and killed nocardia organism - Page 24. Save page Remove ... The induction of delayed hypersensitivity in guinea pigs by viable and killed nocardia organism ... The induction of delayed hypersensitivity in guinea pigs by viable and killed nocardia organism. ...

No FAQ available that match "hypersensitivity delayed"