Hypersensitivity, Delayed
Drug Hypersensitivity
Hypersensitivity
Alveolitis, Extrinsic Allergic
Dermatitis, Contact
Skin Tests
Hypersensitivity, Immediate
Hyperalgesia
Picryl Chloride
Dermatitis, Allergic Contact
Food Hypersensitivity
Immunity, Cellular
Dentin Desensitizing Agents
Haptens
Cell Migration Inhibition
Phenomenon of cell-mediated immunity measured by in vitro inhibition of the migration or phagocytosis of antigen-stimulated LEUKOCYTES or MACROPHAGES. Specific CELL MIGRATION ASSAYS have been developed to estimate levels of migration inhibitory factors, immune reactivity against tumor-associated antigens, and immunosuppressive effects of infectious microorganisms.
Skin
Anaphylaxis
Drug Eruptions
Immunization, Passive
Latex Hypersensitivity
Allergic reaction to products containing processed natural rubber latex such as rubber gloves, condoms, catheters, dental dams, balloons, and sporting equipment. Both T-cell mediated (HYPERSENSITIVITY, DELAYED) and IgE antibody-mediated (HYPERSENSITIVITY, IMMEDIATE) allergic responses are possible. Delayed hypersensitivity results from exposure to antioxidants present in the rubber; immediate hypersensitivity results from exposure to a latex protein.
Respiratory Hypersensitivity
Immunoglobulin E
Tuberculin
Immunization
Deliberate stimulation of the host's immune response. ACTIVE IMMUNIZATION involves administration of ANTIGENS or IMMUNOLOGIC ADJUVANTS. PASSIVE IMMUNIZATION involves administration of IMMUNE SERA or LYMPHOCYTES or their extracts (e.g., transfer factor, immune RNA) or transplantation of immunocompetent cell producing tissue (thymus or bone marrow).
Guinea Pigs
Neuralgia
Freund's Adjuvant
An antigen solution emulsified in mineral oil. The complete form is made up of killed, dried mycobacteria, usually M. tuberculosis, suspended in the oil phase. It is effective in stimulating cell-mediated immunity (IMMUNITY, CELLULAR) and potentiates the production of certain IMMUNOGLOBULINS in some animals. The incomplete form does not contain mycobacteria.
T-Lymphocytes
Lymphocytes responsible for cell-mediated immunity. Two types have been identified - cytotoxic (T-LYMPHOCYTES, CYTOTOXIC) and helper T-lymphocytes (T-LYMPHOCYTES, HELPER-INDUCER). They are formed when lymphocytes circulate through the THYMUS GLAND and differentiate to thymocytes. When exposed to an antigen, they divide rapidly and produce large numbers of new T cells sensitized to that antigen.
Spinal Nerves
Dinitrochlorobenzene
Erythema
Irritable Bowel Syndrome
Pain Measurement
Antibody Formation
Pain
Allergens
Arthus Reaction
Passive Cutaneous Anaphylaxis
An evanescent cutaneous reaction occurring when antibody is injected into a local area on the skin and antigen is subsequently injected intravenously along with a dye. The dye makes the rapidly occurring capillary dilatation and increased vascular permeability readily visible by leakage into the reaction site. PCA is a sensitive reaction for detecting very small quantities of antibodies and is also a method for studying the mechanisms of immediate hypersensitivity.
Immune Tolerance
The specific failure of a normally responsive individual to make an immune response to a known antigen. It results from previous contact with the antigen by an immunologically immature individual (fetus or neonate) or by an adult exposed to extreme high-dose or low-dose antigen, or by exposure to radiation, antimetabolites, antilymphocytic serum, etc.
Langerhans Cells
Recirculating, dendritic, antigen-presenting cells containing characteristic racket-shaped granules (Birbeck granules). They are found principally in the stratum spinosum of the EPIDERMIS and are rich in Class II MAJOR HISTOCOMPATIBILITY COMPLEX molecules. Langerhans cells were the first dendritic cell to be described and have been a model of study for other dendritic cells (DCs), especially other migrating DCs such as dermal DCs and INTERSTITIAL DENDRITIC CELLS.
Disease Models, Animal
Bird Fancier's Lung
BCG Vaccine
Nociception
Lymphocyte Activation
Morphologic alteration of small B LYMPHOCYTES or T LYMPHOCYTES in culture into large blast-like cells able to synthesize DNA and RNA and to divide mitotically. It is induced by INTERLEUKINS; MITOGENS such as PHYTOHEMAGGLUTININS, and by specific ANTIGENS. It may also occur in vivo as in GRAFT REJECTION.
Visceral Pain
Lymphocytes
White blood cells formed in the body's lymphoid tissue. The nucleus is round or ovoid with coarse, irregularly clumped chromatin while the cytoplasm is typically pale blue with azurophilic (if any) granules. Most lymphocytes can be classified as either T or B (with subpopulations of each), or NATURAL KILLER CELLS.
Patch Tests
Deoxyribonuclease I
An enzyme capable of hydrolyzing highly polymerized DNA by splitting phosphodiester linkages, preferentially adjacent to a pyrimidine nucleotide. This catalyzes endonucleolytic cleavage of DNA yielding 5'-phosphodi- and oligonucleotide end-products. The enzyme has a preference for double-stranded DNA.
Mice, Knockout
Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.
Environmental Illness
A polysymptomatic condition believed by clinical ecologists to result from immune dysregulation induced by common foods, allergens, and chemicals, resulting in various physical and mental disorders. The medical community has remained largely skeptical of the existence of this "disease", given the plethora of symptoms attributed to environmental illness, the lack of reproducible laboratory abnormalities, and the use of unproven therapies to treat the condition. (From Segen, Dictionary of Modern Medicine, 1992)
Dose-Response Relationship, Immunologic
Basophils
Saccharopolyspora
Farmer's Lung
A form of alveolitis or pneumonitis due to an acquired hypersensitivity to inhaled antigens associated with farm environment. Antigens in the farm dust are commonly from bacteria actinomycetes (SACCHAROPOLYSPORA and THERMOACTINOMYCES), fungi, and animal proteins in the soil, straw, crops, pelts, serum, and excreta.
Rats, Sprague-Dawley
Ultraviolet Rays
That portion of the electromagnetic spectrum immediately below the visible range and extending into the x-ray frequencies. The longer wavelengths (near-UV or biotic or vital rays) are necessary for the endogenous synthesis of vitamin D and are also called antirachitic rays; the shorter, ionizing wavelengths (far-UV or abiotic or extravital rays) are viricidal, bactericidal, mutagenic, and carcinogenic and are used as disinfectants.
Injections, Intradermal
Nociceptors
Peripheral AFFERENT NEURONS which are sensitive to injuries or pain, usually caused by extreme thermal exposures, mechanical forces, or other noxious stimuli. Their cell bodies reside in the DORSAL ROOT GANGLIA. Their peripheral terminals (NERVE ENDINGS) innervate target tissues and transduce noxious stimuli via axons to the CENTRAL NERVOUS SYSTEM.
Mast Cells
Granulated cells that are found in almost all tissues, most abundantly in the skin and the gastrointestinal tract. Like the BASOPHILS, mast cells contain large amounts of HISTAMINE and HEPARIN. Unlike basophils, mast cells normally remain in the tissues and do not circulate in the blood. Mast cells, derived from the bone marrow stem cells, are regulated by the STEM CELL FACTOR.
Lymph Nodes
Mice, Inbred Strains
Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations, or by parent x offspring matings carried out with certain restrictions. All animals within an inbred strain trace back to a common ancestor in the twentieth generation.
Streptodornase and Streptokinase
A mixture of the enzymes (streptokinase and streptodornase) produced by hemolytic streptococci. It is used topically on surface lesions and by instillation in closed body cavities to remove clotted blood or fibrinous or purulent accumulations. It is also used as a skin test antigen in evaluating generalized cell-mediated immunodeficiency. (Dorland, 27th ed) EC 3.-.
Adjuvants, Immunologic
Substances that augment, stimulate, activate, potentiate, or modulate the immune response at either the cellular or humoral level. The classical agents (Freund's adjuvant, BCG, Corynebacterium parvum, et al.) contain bacterial antigens. Some are endogenous (e.g., histamine, interferon, transfer factor, tuftsin, interleukin-1). Their mode of action is either non-specific, resulting in increased immune responsiveness to a wide variety of antigens, or antigen-specific, i.e., affecting a restricted type of immune response to a narrow group of antigens. The therapeutic efficacy of many biological response modifiers is related to their antigen-specific immunoadjuvanticity.
Irritants
Drugs that act locally on cutaneous or mucosal surfaces to produce inflammation; those that cause redness due to hyperemia are rubefacients; those that raise blisters are vesicants and those that penetrate sebaceous glands and cause abscesses are pustulants; tear gases and mustard gases are also irritants.
Ear
The hearing and equilibrium system of the body. It consists of three parts: the EXTERNAL EAR, the MIDDLE EAR, and the INNER EAR. Sound waves are transmitted through this organ where vibration is transduced to nerve signals that pass through the ACOUSTIC NERVE to the CENTRAL NERVOUS SYSTEM. The inner ear also contains the vestibular organ that maintains equilibrium by transducing signals to the VESTIBULAR NERVE.
Viscera
Spinal Cord
Exanthema
Diseases in which skin eruptions or rashes are a prominent manifestation. Classically, six such diseases were described with similar rashes; they were numbered in the order in which they were reported. Only the fourth (Duke's disease), fifth (ERYTHEMA INFECTIOSUM), and sixth (EXANTHEMA SUBITUM) numeric designations survive as occasional synonyms in current terminology.
Desensitization, Immunologic
Immunosuppression
Deliberate prevention or diminution of the host's immune response. It may be nonspecific as in the administration of immunosuppressive agents (drugs or radiation) or by lymphocyte depletion or may be specific as in desensitization or the simultaneous administration of antigen and immunosuppressive drugs.
Ear, External
Toothpastes
Carbamazepine
Urticaria
Mycobacterium bovis
Cytokines
Non-antibody proteins secreted by inflammatory leukocytes and some non-leukocytic cells, that act as intercellular mediators. They differ from classical hormones in that they are produced by a number of tissue or cell types rather than by specialized glands. They generally act locally in a paracrine or autocrine rather than endocrine manner.
Immunity
Injections, Spinal
Milk Hypersensitivity
Stevens-Johnson Syndrome
Rare cutaneous eruption characterized by extensive KERATINOCYTE apoptosis resulting in skin detachment with mucosal involvement. It is often provoked by the use of drugs (e.g., antibiotics and anticonvulsants) or associated with PNEUMONIA, MYCOPLASMA. It is considered a continuum of Toxic Epidermal Necrolysis.
Sensory Receptor Cells
Dideoxynucleosides
Nucleosides that have two hydroxy groups removed from the sugar moiety. The majority of these compounds have broad-spectrum antiretroviral activity due to their action as antimetabolites. The nucleosides are phosphorylated intracellularly to their 5'-triphosphates and act as chain-terminating inhibitors of viral reverse transcription.
Diphenhydramine
Fanconi Anemia
Congenital disorder affecting all bone marrow elements, resulting in ANEMIA; LEUKOPENIA; and THROMBOPENIA, and associated with cardiac, renal, and limb malformations as well as dermal pigmentary changes. Spontaneous CHROMOSOME BREAKAGE is a feature of this disease along with predisposition to LEUKEMIA. There are at least 7 complementation groups in Fanconi anemia: FANCA, FANCB, FANCC, FANCD1, FANCD2, FANCE, FANCF, FANCG, and FANCL. (from Online Mendelian Inheritance in Man, http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=227650, August 20, 2004)
Inflammation
Mutation
Ganglia, Spinal
Sensory ganglia located on the dorsal spinal roots within the vertebral column. The spinal ganglion cells are pseudounipolar. The single primary branch bifurcates sending a peripheral process to carry sensory information from the periphery and a central branch which relays that information to the spinal cord or brain.
Hyperesthesia
Granuloma
Anterior Chamber
The space in the eye, filled with aqueous humor, bounded anteriorly by the cornea and a small portion of the sclera and posteriorly by a small portion of the ciliary body, the iris, and that part of the crystalline lens which presents through the pupil. (Cline et al., Dictionary of Visual Science, 4th ed, p109)
Sulfamethoxazole
Immunoglobulin G
Posterior Horn Cells
Neurons in the SPINAL CORD DORSAL HORN whose cell bodies and processes are confined entirely to the CENTRAL NERVOUS SYSTEM. They receive collateral or direct terminations of dorsal root fibers. They send their axons either directly to ANTERIOR HORN CELLS or to the WHITE MATTER ascending and descending longitudinal fibers.
Interferon-gamma
The major interferon produced by mitogenically or antigenically stimulated LYMPHOCYTES. It is structurally different from TYPE I INTERFERON and its major activity is immunoregulation. It has been implicated in the expression of CLASS II HISTOCOMPATIBILITY ANTIGENS in cells that do not normally produce them, leading to AUTOIMMUNE DISEASES.
Tuberculin Test
Drug Hypersensitivity Syndrome
Macrophages
The relatively long-lived phagocytic cell of mammalian tissues that are derived from blood MONOCYTES. Main types are PERITONEAL MACROPHAGES; ALVEOLAR MACROPHAGES; HISTIOCYTES; KUPFFER CELLS of the liver; and OSTEOCLASTS. They may further differentiate within chronic inflammatory lesions to EPITHELIOID CELLS or may fuse to form FOREIGN BODY GIANT CELLS or LANGHANS GIANT CELLS. (from The Dictionary of Cell Biology, Lackie and Dow, 3rd ed.)
Thioxanthenes
Edema
T-Lymphocytes, Regulatory
Cells, Cultured
Dose-Response Relationship, Drug
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Colon
Touch
Th2 Cells
Cross Reactions
TRPV Cation Channels
Antibodies
Phenotype
Fanconi Anemia Complementation Group Proteins
DNA Damage
Injuries to DNA that introduce deviations from its normal, intact structure and which may, if left unrepaired, result in a MUTATION or a block of DNA REPLICATION. These deviations may be caused by physical or chemical agents and occur by natural or unnatural, introduced circumstances. They include the introduction of illegitimate bases during replication or by deamination or other modification of bases; the loss of a base from the DNA backbone leaving an abasic site; single-strand breaks; double strand breaks; and intrastrand (PYRIMIDINE DIMERS) or interstrand crosslinking. Damage can often be repaired (DNA REPAIR). If the damage is extensive, it can induce APOPTOSIS.
Dermatitis, Occupational
DNA Repair
The reconstruction of a continuous two-stranded DNA molecule without mismatch from a molecule which contained damaged regions. The major repair mechanisms are excision repair, in which defective regions in one strand are excised and resynthesized using the complementary base pairing information in the intact strand; photoreactivation repair, in which the lethal and mutagenic effects of ultraviolet light are eliminated; and post-replication repair, in which the primary lesions are not repaired, but the gaps in one daughter duplex are filled in by incorporation of portions of the other (undamaged) daughter duplex. Excision repair and post-replication repair are sometimes referred to as "dark repair" because they do not require light.
Serum Albumin, Bovine
Immunity, Maternally-Acquired
Dentifrices
Leukocytes
Dapsone
A sulfone active against a wide range of bacteria but mainly employed for its actions against MYCOBACTERIUM LEPRAE. Its mechanism of action is probably similar to that of the SULFONAMIDES which involves inhibition of folic acid synthesis in susceptible organisms. It is also used with PYRIMETHAMINE in the treatment of malaria. (From Martindale, The Extra Pharmacopoeia, 30th ed, p157-8)
Leukocyte Count
Carrageenan
Macrophage Migration-Inhibitory Factors
Reflex, Abdominal
Contractions of the abdominal muscles upon stimulation of the skin (superficial abdominal reflex) or tapping neighboring bony structures (deep abdominal reflex). The superficial reflex may be weak or absent, for example, after a stroke, a sign of upper (suprasegmental) motor neuron lesions. (Stedman, 25th ed & Best & Taylor's Physiological Basis of Medical Practice, 12th ed, p1073)
Th1 Cells
Subset of helper-inducer T-lymphocytes which synthesize and secrete interleukin-2, gamma-interferon, and interleukin-12. Due to their ability to kill antigen-presenting cells and their lymphokine-mediated effector activity, Th1 cells are associated with vigorous delayed-type hypersensitivity reactions.
Adoptive Transfer
Administration, Cutaneous
Cyclophosphamide
Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the LIVER to form the active aldophosphamide. It has been used in the treatment of LYMPHOMA and LEUKEMIA. Its side effect, ALOPECIA, has been used for defleecing sheep. Cyclophosphamide may also cause sterility, birth defects, mutations, and cancer.
Fanconi Anemia Complementation Group C Protein
Interleukin-4
Sciatic Nerve
A nerve which originates in the lumbar and sacral spinal cord (L4 to S3) and supplies motor and sensory innervation to the lower extremity. The sciatic nerve, which is the main continuation of the sacral plexus, is the largest nerve in the body. It has two major branches, the TIBIAL NERVE and the PERONEAL NERVE.
Mustard Plant
Any of several BRASSICA species that are commonly called mustard. Brassica alba is white mustard, B. juncea is brown or Chinese mustard, and B. nigra is black, brown, or red mustard. The plant is grown both for mustard seed from which oil is extracted or used as SPICES, and for its greens used as VEGETABLES or ANIMAL FEED. There is no relationship to MUSTARD COMPOUNDS.
Lung
Anti-Allergic Agents
gamma-Globulins
Serum globulins that migrate to the gamma region (most positively charged) upon ELECTROPHORESIS. At one time, gamma-globulins came to be used as a synonym for immunoglobulins since most immunoglobulins are gamma globulins and conversely most gamma globulins are immunoglobulins. But since some immunoglobulins exhibit an alpha or beta electrophoretic mobility, that usage is in decline.
Transient Receptor Potential Channels
A broad group of eukaryotic six-transmembrane cation channels that are classified by sequence homology because their functional involvement with SENSATION is varied. They have only weak voltage sensitivity and ion selectivity. They are named after a DROSOPHILA mutant that displayed transient receptor potentials in response to light. A 25-amino-acid motif containing a TRP box (EWKFAR) just C-terminal to S6 is found in TRPC, TRPV and TRPM subgroups. ANKYRIN repeats are found in TRPC, TRPV & TRPN subgroups. Some are functionally associated with TYROSINE KINASE or TYPE C PHOSPHOLIPASES.
Immunity, Active
Granuloma, Respiratory Tract
Foot
Colonic Diseases, Functional
Base Sequence
Histamine H1 Antagonists
Drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine. Included here are the classical antihistaminics that antagonize or prevent the action of histamine mainly in immediate hypersensitivity. They act in the bronchi, capillaries, and some other smooth muscles, and are used to prevent or allay motion sickness, seasonal rhinitis, and allergic dermatitis and to induce somnolence. The effects of blocking central nervous system H1 receptors are not as well understood.
Cryptococcus
Dermatitis, Irritant
Mitomycin
Peripheral Nervous System Diseases
Antigen-Antibody Reactions
HLA-B Antigens
Class I human histocompatibility (HLA) surface antigens encoded by more than 30 detectable alleles on locus B of the HLA complex, the most polymorphic of all the HLA specificities. Several of these antigens (e.g., HLA-B27, -B7, -B8) are strongly associated with predisposition to rheumatoid and other autoimmune disorders. Like other class I HLA determinants, they are involved in the cellular immune reactivity of cytolytic T lymphocytes.
Sciatic Neuropathy
Disease or damage involving the SCIATIC NERVE, which divides into the PERONEAL NERVE and TIBIAL NERVE (see also PERONEAL NEUROPATHIES and TIBIAL NEUROPATHY). Clinical manifestations may include SCIATICA or pain localized to the hip, PARESIS or PARALYSIS of posterior thigh muscles and muscles innervated by the peroneal and tibial nerves, and sensory loss involving the lateral and posterior thigh, posterior and lateral leg, and sole of the foot. The sciatic nerve may be affected by trauma; ISCHEMIA; COLLAGEN DISEASES; and other conditions. (From Adams et al., Principles of Neurology, 6th ed, p1363)
Signal Transduction
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
Multiple Chemical Sensitivity
An acquired disorder characterized by recurrent symptoms, referable to multiple organ systems, occurring in response to demonstrable exposure to many chemically unrelated compounds at doses below those established in the general population to cause harmful effects. (Cullen MR. The worker with multiple chemical sensitivities: an overview. Occup Med 1987;2(4):655-61)
Dental Occlusion, Traumatic
Interleukin-10
A cytokine produced by a variety of cell types, including T-LYMPHOCYTES; MONOCYTES; DENDRITIC CELLS; and EPITHELIAL CELLS that exerts a variety of effects on immunoregulation and INFLAMMATION. Interleukin-10 combines with itself to form a homodimeric molecule that is the biologically active form of the protein.
Administration, Topical
The application of drug preparations to the surfaces of the body, especially the skin (ADMINISTRATION, CUTANEOUS) or mucous membranes. This method of treatment is used to avoid systemic side effects when high doses are required at a localized area or as an alternative systemic administration route, to avoid hepatic processing for example.
Emergent immunoregulatory properties of combined glucocorticoid and anti-glucocorticoid steroids in a model of tuberculosis. (1/2860)
In Balb/c mice with pulmonary tuberculosis, there is a switch from a protective Th1-dominated cytokine profile to a non-protective profile with a Th2 component. This switch occurs while the adrenals are undergoing marked hyperplasia. Treatment with the anti-glucocorticoid hormones dehydroepiandrosterone or 3 beta, 17 beta-androstenediol, during the period of adrenal hyperplasia, maintains Th1 dominance and is protective. We investigated the effects of these hormones as therapeutic agents by administering them from day 60, when the switch to the non-protective cytokine profile was already well established. Given at this time (day 60), doses that were protective when given early (from day 0) were rapidly fatal. A physiological dose of the glucocorticoid corticosterone was also rapidly fatal. However when the corticosterone and the anti-glucocorticoid (AED or DHEA) were co-administered, there was protection, with restoration of a Th1-dominated cytokine profile, enhanced DTH responses, and enhanced expression of IL-1 alpha and TNF alpha. Therefore this combination of steroids has an emergent property that is quite unlike that of either type of steroid given alone. It may be possible to exploit the ant-inflammatory properties of glucocorticoids while preserving a Th1 bias, by combining glucocorticoids with DHEA or suitable metabolites. (+info)Biophysical characterization of a designed TMV coat protein mutant, R46G, that elicits a moderate hypersensitivity response in Nicotiana sylvestris. (2/2860)
The hypersensitivity resistance response directed by the N' gene in Nicotiana sylvestris is elicited by the tobacco mosaic virus (TMV) coat protein R46G, but not by the U1 wild-type TMV coat protein. In this study, the structural and hydrodynamic properties of R46G and wild-type coat proteins were compared for variations that may explain N' gene elicitation. Circular dichroism spectroscopy reveals no significant secondary or tertiary structural differences between the elicitor and nonelicitor coat proteins. Analytical ultracentrifugation studies, however, do show different concentration dependencies of the weight average sedimentation coefficients at 4 degrees C. Viral reconstitution kinetics at 20 degrees C were used to determine viral assembly rates and as an initial assay of the rate of 20S formation, the obligate species for viral reconstitution. These kinetic results reveal a decreased lag time for reconstitution performed with R46G that initially lack the 20S aggregate. However, experiments performed with 20S initially present reveal no detectable differences indicating that the mechanism of viral assembly is similar for the two coat protein species. Therefore, an increased rate of 20S formation from R46G subunits may explain the differences in the viral reconstitution lag times. The inferred increase in the rate of 20S formation is verified by direct measurement of the 20S boundary as a function of time at 20 degrees C using velocity sedimentation analysis. These results are consistent with the interpretation that there may be an altered size distribution and/or lifetime of the small coat protein aggregates in elicitors that allows N. sylvestris to recognize the invading virus. (+info)Vascularity in asthmatic airways: relation to inhaled steroid dose. (3/2860)
BACKGROUND: There is an increase in vascularity in the asthmatic airway. Although inhaled corticosteroids (ICS) are an effective anti-inflammatory treatment in asthma, there are few data on any effects on structural changes. METHODS: Endobronchial biopsy specimens from seven asthmatic subjects not receiving ICS and 15 receiving 200-1500 microg/day beclomethasone dipropionate (BDP) were immunohistochemically stained with an anti-collagen type IV antibody to outline the endothelial basement membrane of the vessels. These were compared with biopsy tissue from 11 non-asthmatic controls (four atopic and seven non-atopic). RESULTS: There was a significant increase in the density of vessels (number of vessels/mm2 of lamina propria) in the asthmatic subjects not on ICS compared with non-asthmatic controls (mean 485 (interquartile range (IQR) 390-597) versus 329 (IQR 248-376) vessels/mm2, p<0.05; 95% CI for the difference 48 to 286). There was no significant difference between asthmatic subjects on ICS and those not on ICS or control subjects in the number of vessels/mm2 (mean 421 (IQR 281-534)). However, patients who received >/=800 microg/day BDP tended to have a reduced number of vessels/mm2 compared with patients not on ICS and those receiving +info)IL-10-induced anergy in peripheral T cell and reactivation by microenvironmental cytokines: two key steps in specific immunotherapy. (4/2860)
Specific immunotherapy (SIT) is widely used for treatment of allergic diseases and could potentially be applied in other immunological disorders. Induction of specific unresponsiveness (anergy) in peripheral T cells and recovery by cytokines from the tissue microenvironment represent two key steps in SIT with whole allergen or antigenic T cell peptides (PIT). The anergy is directed against the T cell epitopes of the respective antigen and characterized by suppressed proliferative and cytokine responses. It is initiated by autocrine action of IL-10, which is increasingly produced by the antigen-specific T cells. Later in therapy, B cells and monocytes also produce IL-10. The anergic T cells can be reactivated by different cytokines. Whereas IL-15 and IL-2 generate Th1 cytokine profile and an IgG4 antibody response, IL-4 reactivates a Th2 cytokine pattern and IgE antibodies. Increased IL-10 suppresses IgE and enhances IgG4 synthesis, resulting in a decreased antigen-specific IgE:IgG4 ratio, as observed normally in patients after SIT or PIT. The same state of anergy against the major bee venom allergen, phospholipase A2, can be observed in subjects naturally anergized after multiple bee stings. Together, these data demonstrate the pivotal role of autocrine IL-10 in induction of specific T cell anergy and the important participation of the cytokine microenvironment in SIT. Furthermore, knowledge of the mechanisms explaining reasons for success or failure of SIT may enable possible predictive measures of the treatment. (+info)Pen c 1, a novel enzymic allergen protein from Penicillium citrinum. Purification, characterization, cloning and expression. (5/2860)
A 33-kDa alkaline serine protease secreted by Penicillium citrinum strain 52-5 is shown to be an allergenic agent in this fungus. The protein, designated Pen c 1, was purified by sequential DEAE-Sepharose and carboxymethyl (CM)-Sepharose chromatographies. Pen c 1 has a molecular mass of 33 kDa and a pI of 7.1. The caseinolytic enzyme activity of this protein was studied. The protein binds to serum IgE from patients allergic to Penicillium citrinum. The cDNA encoding Pen c 1 is 1420 bp in length and contains an open reading frame for a 397-amino-acid polypeptide. Pen c 1 codes for a larger precursor containing a signal peptide, a propeptide and the 33-kDa mature protein. Sequence comparison revealed that Pen c 1 possesses several features in common with the alkaline serine proteases of the subtilisin family. The essential Asp, His, and Ser residues that make up the catalytic triad of serine proteases are well conserved. Northern blots demonstrated that mRNAs transcribed from this gene are present at early stages of culture. The allergen encoded by Pen c 1 gene was expressed in Escherichia coli as a fusion protein bearing an N-terminal histidine-affinity tag. The protein, purified by affinity chromatography with a yield of 130 mg of pure protein per liter of culture, was able to bind to both a monoclonal anti-Pen c 1 antibody and IgE from the serum of patients allergic to Penicillium. Recombinant Pen c 1 can therefore be expressed in E. coli in large quantities and should prove useful as a standardized specific allergen for immuno-diagnosis of atopic disorders. In addition, full caseinolytic enzyme activity could be generated in the purified recombinant protein by sulfonation and renaturation, followed by removal of the affinity tag, indicating that the refolded protein can assume the same conformation as the native protein. (+info)In vitro and skin testing for allergy: comparable clinical utility and costs. (6/2860)
Controversy exists concerning the appropriate use of skin testing and in vitro testing for the diagnosis of allergy, particularly inhalant allergy. Earlier comparisons of skin testing and in vitro testing concluded that skin testing had superior accuracy at lower expense. In light of new developments with in vitro allergy testing, however, this issue should be reconsidered. A review of the recent scientific literature indicates that in vitro and skin testing are highly correlated. However, without the existence of an independent gold standard for inhalant allergy, it is not possible to determine which test is more accurate. The accuracy of either test can be compromised if conducted using different protocols or having insufficient quality control. Given their respective trajectories for technological advancement, quantification, and quality control, in vitro testing may offer the more standardized approach. Although the cost per test of in vitro testing remains greater than that of skin testing, the per-patient costs of the two modalities appear to be comparable, given the greater number of allergens typically used in skin testing. In summary, both skin testing and in vitro testing are acceptable as frontline diagnostic tools. (+info)Characterization of Epstein-Barr virus (EBV)-infected natural killer (NK) cell proliferation in patients with severe mosquito allergy; establishment of an IL-2-dependent NK-like cell line. (7/2860)
The clinical evidence of a relationship between severe hypersensitivity to mosquito bite (HMB) and clonal expansion of EBV-infected NK cells has been accumulated. In order to clarify the mechanism of EBV-induced NK cell proliferation and its relationship with high incidence of leukaemias or lymphomas in HMB patients, we studied clonally expanded NK cells from three HMB patients and succeeded in establishing an EBV-infected NK-like cell line designated KAI3. Immunoblotting and reverse transcriptase-polymerase chain reaction (RT-PCR) analyses revealed that KAI3 cells as well as infected NK cells exhibited an EBV latent infection type II, where EBV gene expression was limited to EBNA 1 and LMP1. As KAI3 was established by culture with IL-2, IL-2 responsiveness of peripheral blood NK cells from patients was examined. The results represented markedly augmented IL-2-induced IL-2R alpha expression in NK cells. This characteristic property may contribute to the persistent expansion of infected NK cells. However, KAI3 cells as well as the NK cells from patients were not protected from apoptosis induced by either an anti-Fas antibody or NK-sensitive K562 cells. Preserved sensitivity to apoptosis might explain the relatively regulated NK cell numbers in the peripheral blood of the patients. To our knowledge, KAI3 is the first reported NK-like cell line established from patients of severe chronic active EBV infection (SCAEBV) before the onset of leukaemias or lymphomas. KAI3 cells will contribute to the study of EBV persistency in the NK cell environment and its relationship with high incidence of leukaemias or lymphomas in HMB patients. (+info)Detection of allergen-induced basophil activation by expression of CD63 antigen using a tricolour flow cytometric method. (8/2860)
In the field of allergy diagnosis, most in vitro functional tests are focused on basophils. Nevertheless, the very small number of circulating basophils limits these experiments and their clinical benefit remains controversial. As flow cytometry is a valuable tool for identifying cell populations, even at low concentrations, we developed a tricolour flow cytometric method for the study of allergen-induced basophil activation. Identification of cells was based both on CD45 expression and on the presence of IgE on the cell surface, since basophils express high-affinity receptors for IgE (Fc epsilon RI). Cell activation upon allergen challenge was assessed by the expression of CD63 antigen on the plasma membrane. Basophil isolation and activation (with the chemotactic peptide formyl-methionyl-leucyl-phenylalanine) were validated in 32 non-allergic patients. In 12 allergic patients, basophil stimulation by a relevant allergen was in most cases positive (10/12). Furthermore a concentration-dependent hook effect was observed. Of the allergic and non-allergic patients, none showed non-specific activation with an irrelevant allergen (specificity 100%). Overall, our preliminary results, even in a small population, suggest that this is a reliable and valuable method for the diagnosis of allergies complementing specific allergen IgE and skin test results. Obviously, additional clinical studies are needed to validate these first results. (+info)
MELISA and metal hypersensitivity - Wilderman Medical Clinic - Pain Clinic in Toronto AreaWilderman Medical Clinic - Pain...
An 18-year Follow-up of Allergy Development Related to Nasal Metachromatic Cell Findings During Infancy
The role of prenatal diet- and microbiome- derived metabolome in childhood allergy development. Metabolic fingerprinting for...
Polyunsaturated fatty acids and allergy development
Pregnancy, but not the allergic status, influences spontaneous and induced IL-1beta, IL-6, IL-10 and IL-12 responses
Supplementary Material for: The Impact on Allergy-Related Cells of a Birch Pollen Allergoid, with and without Monophosphoryl...
Allergy Risk: Pollenwarndienst
Understanding administrative coding of emergency department visits for unspecified acute allergic reactions
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Immunological interactions between mother and child during pregnancy in relation to the development of allergic diseases in the...
Allergens are the reasons of allergic reactions appearance and allergy development.
Survey of the allergic status of patients with bronchial asthma in Turkey: a multicenter study - Kalyoncu - 2007 - Allergy -...
Infographic on Allergy
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Inquiries on allergy and antihistamines | Ask The Doctor
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Protein shakes recalled over allergy risk - Bexhill Observer
Mobile phone radiation and health
Electromagnetic hypersensitivity[edit]. Main article: Electromagnetic hypersensitivity. Some users of mobile phones and similar ...
Tooth whitening
Hypersensitivity[edit]. Main article: Dentine hypersensitivity. The use of bleach with extremely low pH levels in the tooth ... Reduced concentrations of hydrogen peroxide cause lower incidences of tooth hypersensitivity.[39] The nanoparticles act as ... there is no evidence to suggest that this is a permanent method to eradicate the issue of hypersensitivity.[51] ...
Iodinated contrast
Hypersensitivity reactions[edit]. Anaphylactoid reactions occur rarely,[4][5][6] but can occur in response to injected as well ... blockers have been assumed as risk factor for the acquisition of contrast medium-induced adverse reactions/hypersensitivity ...
T helper cell
Hypersensitivity reactions can be divided into four types: *Type 1 hypersensitivity includes common immune disorders such as ... Type 4 hypersensitivity, also known as delayed type hypersensitivity, are caused via the over-stimulation of immune cells, ... Hypersensitivity[edit]. The immune system must achieve a balance of sensitivity in order to respond to foreign antigens without ... Other cellular hypersensitivities include cytotoxic T cell mediated auto-immune disease, and a similar phenomenon; transplant ...
Nocebo
Electromagnetic hypersensitivity[edit]. Evidence suggests that the symptoms of electromagnetic hypersensitivity are caused by ... electromagnetic hypersensitivity'): An updated systematic review of provocation studies". Bioelectromagnetics. 31 (1): 1-11. ...
Arachidonate 5-lipoxygenase
Hypersensitivity reactions[edit]. ALOX5 contributes to non-allergic reactions of the respiratory system and skin such as ... LTC4, LTD4, and LTE4 contribute to allergic airways reactions such as asthma, certain non-allergic hypersensitivity airways ... it may also contribute to hypersensitivity responses of the respiratory system to cold air and possibly even alcohol beverages ... "Classification and practical approach to the diagnosis and management of hypersensitivity to nonsteroidal anti-inflammatory ...
Immune tolerance
Oral tolerance and hypersensitivity[edit]. See also: Goblet cell § Role in oral tolerance ... Allergy and hypersensitivity reactions in general are traditionally thought of as misguided or excessive reactions by the ... It may also have evolved to prevent hypersensitivity reactions to food proteins.[27] It is of immense immunological importance ... Records from 1829 indicate that American Indians would reduce contact hypersensitivity from poison ivy by consuming leaves of ...
Szondi test
... hypersensitivity; obstinacy, stubbornness; Inability to debate, self-consciousness; narrow-mindedness, bigotry; compulsiveness ...
Stenström technique
... hypersensitivity; pressure damage (necrosis) if hard bandages are applied too tightly; perichondritis (inflammation of the ...
Incisionless Fritsch otoplasty
... hypersensitivity; pain with pressure and cold, pressure damage (necrosis) from too tightly fitting hard bandages; ...
Medrysone
Smolin G (1971). "Medrysone hypersensitivity. Report of a case". Arch. Ophthalmol. 85 (4): 478-9. doi:10.1001/archopht. ...
Occupational lung disease
Hypersensitivity pneumonitis (HP; also called allergic alveolitis, bagpipe lung, or extrinsic allergic alveolitis, EAA) is an ... Selman, Moisés; Pardo, Annie; King, Talmadge E. (2012-12-14). "Hypersensitivity Pneumonitis". American Journal of Respiratory ... hypersensitivity pneumonitis, lung fibrosis), infections, lung cancer and mesothelioma. These diseases can be caused directly ... Siderosis Silicosis Byssinosis Hypersensitivity pneumonitis Bagassosis Bird fancier's lung Farmer's lung Beckett, W. S. (2000- ...
Dapsone
Hypersensitivity reactions occur in 1.4% of persons treated with dapsone, and can be fatal in medical settings with low ... Hypersensitivity reactions occur in some patients. This reaction may be more frequent in patients receiving multiple-drug ... These toxic reactions may also occur as part of the dapsone hypersensitivity syndrome (a form of SCARs-see above) or dapsone ... Joseph MS (1985). "Hypersensitivity reaction to dapsone. Four case reports". Lepr Rev. 56 (4): 315-20. doi:10.5935/0305- ...
Lycoperdonosis
Barrios R. (2008). "Hypersensitivity pneumonitis (extrinsic allergic alveolitis)". Dail and Hammar's Pulmonary Pathology (3rd ... It is one of several types of hypersensitivity pneumonitis caused by different agents that have similar clinical features. ... It is classified as a hypersensitivity pneumonitis (also called extrinsic allergic alveolitis)-an inflammation of the alveoli ... ISBN 978-0-387-72113-2. Peroš-Golubičić T, Sharma OP (2006). "Hypersensitivity pneumonitis". Clinical Atlas of Interstitial ...
Index of oral health and dental articles
Dentine hypersensitivity • Dentinogenesis • Dentinogenesis imperfecta • Dentistry • Dentistry Magazine • Dentistry throughout ...
Candidiasis
"Candidiasis Hypersensitivity". National Council Against Health Fraud. Retrieved 18 January 2014. Kumamoto CA (August 2011). " ... "Candidiasis hypersensitivity". Some practitioners of alternative medicine have promoted these purported conditions and sold ...
Toxic heavy metal
Haines, AT; Nieboer, E (1988). "Chromium hypersensitivity". In Nriagu, JO; Nieboer, E (eds.). Chromium in the Natural and Human ...
Phytase
2009). "Hypersensitivity pneumonitis caused by occupational exposure to phytase". Eur Respir J. 33 (6): 1507-09. doi:10.1183/ ... Phytase has been reported to cause hypersensitivity pneumonitis in a human exposed while adding the enzyme to cattle feed. ... Girard M, Cormier Y (2010). "Hypersensitivity pneuomonitis". Current Opinion in Allergy and Clinical Immunology. 10 (2): 99-103 ...
Wine preservatives
... and Hypersensitivity", Advances in Food Research, Elsevier, pp. 1-76, ISBN 9780120164301, retrieved 2019-05-16 Gunnison, Albert ... F.; Jacobsen, Donald W.; Schwartz, Howard J. (1987). "Sulfite Hypersensitivity. A Critical Review". CRC Critical Reviews in ...
Isotretinoin
The compound 13-cis retinoic acid was first studied in the 1960s at Roche Laboratories in Switzerland by Werner Bollag as a treatment for skin cancer. Experiments completed in 1971 showed that the compound was likely to be ineffective for cancer and, surprisingly, that it could be useful to treat acne. However, they also showed that the compound was likely to cause birth defects, so in light of the events around thalidomide, Roche abandoned the product. In 1975, Gary Peck and Frank Yoder independently rediscovered the drug's use as a treatment of cystic acne while studying it as a treatment for lamellar ichthyosis, and published that work. Roche resumed work on the drug. In clinical trials, subjects were carefully screened to avoid including women who were or might become pregnant. Roche's New Drug Application for isotretinoin for the treatment of acne included data showing that the drug caused birth defects in rabbits. The FDA approved the application in 1982. Scientists involved in the ...
Desvenlafaxine
... is a synthetic form of the isolated major active metabolite of venlafaxine, and is categorized as a serotonin-norepinephrine reuptake inhibitor (SNRI). When most normal metabolizers take venlafaxine, approximately 70% of the dose is metabolized into desvenlafaxine, so the effects of the two drugs are expected to be very similar.[5] It works by blocking the "reuptake" transporters for key neurotransmitters affecting mood, thereby leaving more active neurotransmitters in the synapse. The neurotransmitters affected are serotonin (5-hydroxytryptamine) and norepinephrine (noradrenaline). It is approximately 10 times more potent at inhibiting serotonin uptake than norepinephrine uptake.[6]. ...
Neomycin
It is relatively toxic to humans, and many people have allergic reactions to it.[4] See: Hypersensitivity. Physicians sometimes ... Heidary N, Cohen DE (September 2005). "Hypersensitivity reactions to vaccine components". Dermatitis. 16 (3): 115-20. doi: ...
Allergic inflammation
"Hypersensitivity Reactions, Delayed". EMedicine. Rothenberg ME; Rothenberg, Marc E. (1998). "Eosinophilia". N. Engl. J. Med. ... should not be confused with delayed hypersensitivity Type IV allergic reaction (which takes 48-72 hours to develop and is ...
Iodopropynyl butylcarbamate
Sasseville, D (2004). "Hypersensitivity to preservatives". Dermatol Ther. 17 (3): 251-263. doi:10.1111/j.1396-0296.2004.04028.x ...
Igor P. Kaidashev
"Drug Hypersensitivity" (2016). http://www.poltava.pl.ua/news/1424/ http://www.symposier.com/library_detail/3264/Igor-Kaidashev- ...
Pathophysiology of asthma
"Lecture 14: Hypersensitivity". Archived from the original on 2009-07-21. Retrieved 2008-09-18. "Allergy & Asthma Disease ... "Chapter 65 - Adverse Reactions to Foods: Respiratory Food Hypersensitivity Reactions" 2008. Elsevier. The Australasian Society ... It is usually classified as type I hypersensitivity.) In response to exposure to these triggers, the bronchi (large airways) ...
Bagassosis
Hur, T; Cheng KC; Yang GY (October 1994). "Hypersensitivity pneumonitis: bagassosis". Gaoxiong Yi Xue Ke Xue Za Zhi. 10 (10): ... Bagassosis, an interstitial lung disease, is a type of hypersensitivity pneumonitis attributed to exposure to moldy molasses ( ...
Cutting fluid
... hypersensitivity pneumonitis (HP); and worsening of pre-existing respiratory problems. Safer cutting fluid formulations provide ...
Myxedema
... type II hypersensitivity). Lymphocytes react not only against thyroid receptors, but also any tissue with cells expressing the ...
Aspirin exacerbated respiratory disease
EAACI/WHO classifies the syndrome as one of five types of NSAID hypersensitivity or NSAID hypersensitivity reactions. The ... July 2011). "Hypersensitivity to nonsteroidal anti-inflammatory drugs (NSAIDs) - classification, diagnosis and management: ... The symptoms of respiratory reactions in this syndrome are hypersensitivity reactions to NSAIDs rather than the typically ... October 2013). "Classification and practical approach to the diagnosis and management of hypersensitivity to nonsteroidal anti- ...
Drug hypersensitivity caused by alteration of the MHC-presented self-peptide repertoire | PNAS
Drug hypersensitivity caused by alteration of the MHC-presented self-peptide repertoire. David A. Ostrov, Barry J. Grant, Yuri ... 2011) Drug hypersensitivity and human leukocyte antigens of the major histocompatibility complex. Annu Rev Pharmacol Toxicol 52 ... 2008) The roles of drug metabolism in the pathogenesis of T-cell-mediated drug hypersensitivity. Curr Opin Allergy Clin Immunol ... PBMCs from five HLA-B*57:01-positive donors with a clinical history of abacavir hypersensitivity were pulsed for 15 min with ...
Dentin hypersensitivity - Wikipedia
Dentin hypersensitivity (abbreviated to DH,[1] or DHS,[2] and also termed sensitive dentin,[3] dentin sensitivity,[4] cervical ... Dentin hypersensitivity is a relatively common condition.[1][5] Due to differences in populations studied and methods of ... Dentin hypersensitivity may affect individuals quality of life.[1] Over time, the dentin-pulp complex may adapt to the ... Low-output lasers are also suggested for dentin hypersensitivity, including GaAlAs lasers and Nd:YAG laser.[9] They are thought ...
Hypersensitivity pneumonitis
... : Age-adjusted death rates by state, U.S. residents age 15 and over, 1996-2005 2009-350 March 2009 ... Hypersensitivity pneumonitis: Number of deaths by state, U.S. residents age 15 and over, 2001-2010 2014-811 September 2014 ... Hypersensitivity pneumonitis: Number of deaths by sex, race, age group, and median age at death, U.S. residents age 15 and over ... Hypersensitivity pneumonitis: Death rates (per million population) by race and sex, U.S. residents age 15 and over, 2005-2014 ...
Type IV hypersensitivity - Wikipedia
Type V hypersensitivity. References[edit]. *^ a b c d e f g Kumar, Vinay; Abbas, Abul K.; Aster, Jon C. (2012-05-01). Robbins ... Type 4 hypersensitivity is often called delayed type hypersensitivity as the reaction takes several days to develop. Unlike the ... "Hypersensitivity reactions". www.microbiologybook.org. Retrieved 2016-05-29.. *^ McDonough, K.; Kress, Y.; Bloom, B. R. (July ... "Hypersensitivity reactions". www.microbiologybook.org. University of South Carolina School of Medicine - Microbiology and ...
Cutaneous Basophil Hypersensitivity | SpringerLink
The term cutaneous basophil hypersensitivity (CBH) initially referred to a systemic but evanescent pattern of delayed-onset ... Participation of the basophil in hypersensitivity to antigen-antibody complexes, delayed hypersensitivity and contact allergy. ... Inhibition of delayed hypersensitivity (DH) but not cutaneous basophil hypersensitivity (CBH) in guinea pigs (GP), Fed. Proc. ... Local transfer of delayed hypersensitivity and cutaneous basophil hypersensitivity, J. Immunol. 119: 1987-1993.PubMedGoogle ...
hypersensitivity | FactMonster
hypersensitivity, heightened response in a body tissue to an antigen or foreign substance. The body normally responds to an ... Serum sickness is a similar but milder hypersensitivity to serum proteins or drugs that occurs several weeks after injection of ... Anaphylaxis is the immediate, sometimes fatal hypersensitivity reaction to drugs or serum to which an individual has been ... Individuals with allergic, or atopic, hypersensitivity form special weak types of antibodies, that cause local tissue damage ...
Hypersensitivity pneumonia | pathology | Britannica.com
Hypersensitivity pneumonia: Hypersensitivity pneumonias are a spectrum of disorders that arise from an allergic response to the ... Other articles where Hypersensitivity pneumonia is discussed: pneumonia: ... In pneumonia: Hypersensitivity pneumonia. Hypersensitivity pneumonias are a spectrum of disorders that arise from an allergic ...
Hypersensitivity vasculitis: MedlinePlus Medical Encyclopedia
Hypersensitivity vasculitis is an extreme reaction to a drug, infection, or foreign substance. It leads to inflammation and ... Hypersensitivity vasculitis, or cutaneous small vessel vasculitis, is caused by:. *An allergic reaction to a drug or other ... Hypersensitivity vasculitis is an extreme reaction to a drug, infection, or foreign substance. It leads to inflammation and ... Hypersensitivity vasculitis may look like systemic, necrotizing vasculitis, which can affect blood vessels throughout the body ...
Clozapine-Induced Hypersensitivity Myocarditis* - Redorbit
Unfortunately, drug hypersensitivity with a reaction confined to the heart is difficult to recognize, so that the majority of ... Clozapine-induced hypersensitivity myocarditis should be suspected by psychiatrists and physicians when cardiac dysfunction ... We report a case of hypersensitivity myocarditis secondary to clozapine administration that was diagnosed in vivo for the first ... FIGURE 1. Hypersensitivity myocarditis by clozapine; massive myocardial infiltrates mainly represented by degranulated ...
What causes hypersensitivity to abacavir?
Hypersensitivity to abacavir is immunologically mediated, driven by conventional MHC-I antigen presentation and activation of ... What causes hypersensitivity to abacavir?. Updated: Dec 07, 2018 * Author: Ali Torkamani, PhD; Chief Editor: Karl S Roth, MD ... Mallal S, Phillips E, Carosi G, Molina JM, Workman C, Tomazic J. HLA-B*5701 screening for hypersensitivity to abacavir. N Engl ... Hypersensitivity to abacavir is immunologically mediated, driven by conventional MHC-I antigen presentation and activation of ...
Hypersensitivity pneumonitis: MedlinePlus Medical Encyclopedia
Hypersensitivity pneumonitis is inflammation of the lungs due to breathing in a foreign substance, usually certain types of ... Examples of hypersensitivity pneumonitis include:. Bird fanciers lung: This is the most common type of hypersensitivity ... Hypersensitivity pneumonitis usually occurs in people who work in places where there are high levels of organic dusts, fungus, ... Symptoms of acute hypersensitivity pneumonitis often occur 4 to 6 hours after you have left the area where the offending ...
What Is Hypersensitivity Pneumonitis? Radiology & Treatment
Read about hypersensitivity pneumonitis (acute and chronic), and inflammation of the lung caused by bacteria, mold, fungi, and ... Hypersensitivity Pneumonitis. *What is hypersensitivity pneumonitis and what are its causes?. *What is acute hypersensitivity ... Hypersensitivity Pneumonitis - Symptoms What were your symptoms associated with hypersensitivity pneumonitis? Post. View 2 ... home/lungs health center/lungs a-z list/hypersensitivity pneumonitis center /hypersensitivity pneumonitis article ...
Cutaneous Hypersensitivity to Sulphonamides | The BMJ
Hypersensitivity - Wikiversity
Hypersensitivity to Hip and Knee Implants | SpringerLink
Metal hypersensitivity and total knee arthroplasty. J Am Acad Orthop Surg. 2016;24(2):106-12.PubMedPubMedCentralCrossRefGoogle ... Hypersensitivity reactions associated with endovascular devices. Contact Dermatitis. 2008;59:7-22.PubMedCrossRefGoogle Scholar ... Total knee arthroplasty in patients with hypersensitivity to metals. Int Orthop. 2014;38(2):329-33.PubMedPubMedCentralCrossRef ... Cutaneous and systemic hypersensitivity reactions to metallic implants. Dermatitis. 2011;22(2):65-79.PubMedGoogle Scholar ...
How can esophageal hypersensitivity cause chest pain?
Combat Your current Hypersensitivity With your Tips
... While you might become enticed to start your current house windows to save a ... Combat Your current Hypersensitivity With your Tips * 1. Combat Your current Hypersensitivity With your TipsWhile you might ... A hypersensitivity check knows as well asoppose your current suspicions.Keep the windows and doors shut down if you suffer ... Pollen gathers up on the body along with flowing hair during the day, and maylead to a hypersensitivity when you make an effort ...
Documentary Explores Electromagnetic Hypersensitivity Syndrome
Hypersensitivity reactions to systemic glucocorticoids
Hypersensitivity to polyethylene glycols. J Clin Pharmacol 2013; 53:352.. *Spoerl D, Scherer K, Bircher AJ. Contact urticaria ... Hypersensitivity reactions to systemic glucocorticoids. Author. Rima Rachid, MD. Rima Rachid, MD ... Hypersensitivity reactions to corticosteroids. Clin Rev Allergy Immunol 2014; 47:26.. *Kamm GL, Hagmeyer KO. Allergic-type ... Hypersensitivity to antihistamines. Allergy Asthma Proc 2013; 34:488.. *Rutkowski K, Wagner A. Cetirizine anaphylaxis. Ann ...
Pediatric Hypersensitivity Pneumonitis Differential Diagnoses
In its acute or subacute form, hypersensitivity pneumonitis may be a cause of recurrent pneumonitis. ... Hypersensitivity pneumonitis (HP) refers to a group of disorders caused by a nonatopic immunologic response to an inhaled agent ... Miller MM, Patterson R, Fink JN, Roberts M. Chronic hypersensitivity lung disease with recurrent episodes of hypersensitivity ... encoded search term (Pediatric Hypersensitivity Pneumonitis) and Pediatric Hypersensitivity Pneumonitis What to Read Next on ...
TREATMENT OF HYPERSENSITIVITY - CBio Limited
The present invention relates to a method for inhibiting a hypersensitivity reaction in a subject, wherein said method ... An example of a hypersensitivity reaction is an inflammatory reaction. More specifically, examples of a hypersensitivity ... Hypersensitivity reactions are the result of immune responses acting inappropriately and can be provoked by many antigens. One ... Hypersensitivity reactions are the result of immune responses acting inappropriately and can be provoked by many antigens. One ...
Hypersensitivity Vasculitis: Background, Pathophysiology, Etiology
There are many potential causes of hypersensitivity vasculitis; however, up to 50% of cases are idiopathic. ... Hypersensitivity vasculitis, which is usually represented histopathologically as leukocytoclastic vasculitis (LCV), is a term ... encoded search term (Hypersensitivity Vasculitis) and Hypersensitivity Vasculitis What to Read Next on Medscape. Related ... Several studies from Spain have been conducted on hypersensitivity vasculitis. [9, 10, 11, 12, 13] Hypersensitivity vasculitis ...
Fluoride Action Network | Hypersensitivity
Hypersensitivity. Some individuals are hypersensitive to fluoride. According to the Physicians Desk Reference:. "In ... Case Reports of Hypersensitivity to Ingested Fluorides. In the 1950s, the renowned allergist George Waldbott discovered that ... Hypersensitivity. "In hypersensitive individuals, fluorides occasionally cause skin eruptions such as atopic dermatitis, eczema ... These hypersensitivity reactions usually disappear promptly after discontinuation of the fluoride.". Hypersensitive reactions ...
Hypersensitivity - Wikipedia
Delayed Hypersensitivity Reactions at eMedicine Kumar, Vinay; Abbas, Abul K.; Aster, Jon C., eds. (2014). "Hypersensitivity: ... Hypersensitivity (also called hypersensitivity reaction or intolerance) refers to undesirable reactions produced by the normal ... Hypersensitivity reactions require a pre-sensitized (immune) state of the host. The Gell and Coombs classification of ... ISBN 978-1-4160-2973-1. Rajan, T.V. (2003). "The Gell-Coombs classification of hypersensitivity reactions: A re-interpretation ...
Needs and Opportunities to Study Hypersensitivity Pneumonitis | NHLBI, NIH
Hypersensitivity pneumonitis. J Allergy Clin Immunol 1984;74: 1-9.. *Patel AM, Ryu JH, Reed CE. Hypersensitivity pneumonitis: ... Hypersensitivity pneumonitis. AJR Am J Roentgenol 2000;174:1061-1066.. *Lacasse Y, Selman M, Costabel U, Dalphin JC, Morell M, ... HYPERSENSITIVITY PNEUMONITIS IN CHILDREN. Because pediatric cases of HP are rarely recognized or reported, knowledge is limited ... Hypersensitivity pneumonitis in man: light- and electron-microscopic studies of 18 lung biopsies. Am J Pathol 1983;110:275-289. ...
Hypersensitivity dictionary definition | hypersensitivity defined
... plural hypersensitivities) 1. any heightened immune response to an antigen; an allergy Origin hyper- +Ž sensitivity... ... Direct trauma and/or delayed type hypersensitivity reaction to nickel may occur from nasal rings and jewelry, facial adornments ... Henoch-Schönlein purpura-A syndrome sometimes classified as a hypersensitivity vasculitis, associated with a variety of ... Hypersensitivity. (n.d.). In YourDictionary. Retrieved from https://www.yourdictionary.com/HYPERSENSITIVITY ...
candida hypersensitivity | Science-Based Medicine
Hypersensitivity - Fibromyalgia Message Board - HealthBoards
Re: Hypersensitivity yes I feel silly tho just a soft touch is enough to set me off I find if I bumb myself soft or do ... Re: Hypersensitivity Sorry I thought I was been clear yes its fits in with fibro and no your not alone at all we are here and ... Re: Hypersensitivity yes yes and yes! I feel terrible that it hurts when my kids and husband hug me but i cant stand it. it ... Re: Hypersensitivity No you are not crazy alone or too sensitive.I think that is part of the makeup of fibro.Our nerve endings, ...
Hypersensitivity pneumonitis - definition of Hypersensitivity pneumonitis by The Free Dictionary
Hypersensitivity pneumonitis synonyms, Hypersensitivity pneumonitis pronunciation, Hypersensitivity pneumonitis translation, ... English dictionary definition of Hypersensitivity pneumonitis. adj. 1. Highly or excessively sensitive. 2. Responding ... hypersensitivity. (redirected from Hypersensitivity pneumonitis). Also found in: Thesaurus, Medical, Acronyms, Encyclopedia, ... cryaesthesia, cryesthesia - hypersensitivity to cold. hypersensitivity reaction - an inappropriate and excessive reaction to an ...
ReactionsReactionDentine hypersensitivitySyndromeCutaneousSystemicChronicAllergyClassificationPneumonitis dueDentin hypersensitivityDentinal hypersensitivityEsophageal hypersensitivityVasculitisDiagnosis of HypersensitSymptomsAcute hypersensitivity pneumonitisCase of hypersensitivityPeople with hypersensitivityPrevalenceAntibodiesOrganic dustsPrevent hypersensitivityElectro-hypersensitivityVisceral hypersensitivityIdiopathicSensoryEPIDEMIOLOGYInflammation of the lungsChestMechanismsSubacutePathophysiologyImmune response
Reactions38
- Clinical data suggest that many such reactions involve immune mechanisms, and genetic association studies have identified strong linkages between drug hypersensitivity reactions to several drugs and specific HLA alleles. (pnas.org)
- The danger model, which is in principle compatible with other models, states that danger signals other than the drug itself (e.g., chemical, physical, or viral stress) are required to overcome immune tolerance barriers that otherwise suppress drug hypersensitivity reactions ( 7 ). (pnas.org)
- Hetherington S, McGuirk S, Powell G, Cutrell A, Naderer O, Spreen B. Hypersensitivity reactions during therapy with the nucleoside reverse transcriptase inhibitor abacavir. (medscape.com)
- Hypersensitivity reactions to hip and knee implant components are well documented in the literature but remain uncommon. (springer.com)
- Cutaneous and systemic hypersensitivity reactions to metallic implants. (springer.com)
- Make use of supporters or a central atmosphere program to flow theenvironment alternatively, which should minimize the allergic reactions.In the event that hypersensitivity tend to be leading to onto your nose for you to tricklecontinually, you may experience chafing, soreness and ache close to your nasal passages.Using document flesh to prevent drains could make this issue worse. (slideshare.net)
- However, injected, infused, or orally administered systemic glucocorticoids have been associated with immediate hypersensitivity (allergic) reactions, including life-threatening anaphylaxis. (uptodate.com)
- This topic will review the epidemiology, clinical manifestations, diagnosis, and management of hypersensitivity reactions to systemic glucocorticoids. (uptodate.com)
- Hypersensitivity reactions to systemic glucocorticoids are rare, although the exact incidence is unknown. (uptodate.com)
- These hypersensitivity reactions usually disappear promptly after discontinuation of the fluoride. (fluoridealert.org)
- Hypersensitivity reactions to chemotherapy, although rare, have been reported with most chemotherapy drugs. (wellness.com)
- The doctor will begin by ruling out such other possible diagnoses as bacterial or viral infections, collagen vascular disease, hypersensitivity reactions, and malignant tumors. (yourdictionary.com)
- Hypersensitivity (also called hypersensitivity reaction or intolerance) refers to undesirable reactions produced by the normal immune system, including allergies and autoimmunity. (wikipedia.org)
- Hypersensitivity reactions require a pre-sensitized (immune) state of the host. (wikipedia.org)
- Hypersensitivity refers to undesirable (damaging, discomfort-producing and sometimes fatal) reactions produced by the normal immune system. (bionity.com)
- Although hypersensitivity to glycopeptides is rare, both immune-mediated and delayed reactions have been reported in the literature. (mdpi.com)
- We describe the various types of glycopeptide hypersensitivity reactions associated with glycopeptides and lipoglycopeptides, including IgE-mediated reactions, RMS, and linear immunoglobulin A bullous dermatosis, as well as describe cross-reactivity with other glycopeptides. (mdpi.com)
- Prevalence of hypersensitivity reactions in children associated with acetaminophen. (greenmedinfo.com)
- Chemotherapeutic agents may induce hypersensitivity reactions in pediatric patients. (greenmedinfo.com)
- Their extensive use over the last decade has led to a significant increase in the incidence of hypersensitivity reactions, which are defined as unforeseen reactions whose signs and symptoms cannot be explained by the known toxicity of these drugs. (hindawi.com)
- Hypersensitivity reactions in patients receiving cisplatin were first described in the 1970s in patients who had been retreated with the drug [ 31 ]. (hindawi.com)
- The aim of this paper is to provide recent data concerning hypersensitivity reactions to platinum-containing chemotherapy agents. (hindawi.com)
- Extensive use of platinum compounds in chemotherapy during the last decade has led to a significant increase in the incidence of hypersensitivity reactions (Table 1 ). (hindawi.com)
- Using a controlled, single-blind challenge method, pretreatment with intravaginal 4% cromalyn sodium in a water-based cream completely blocked both local and cutaneous immediate hypersensitivity reactions to SF in this highly sensitive patient. (ingentaconnect.com)
- HLA-A*3101 and carbamazepine-induced hypersensitivity reactions in Europeans. (uniprot.org)
- Carbamazepine causes various forms of hypersensitivity reactions, ranging from maculopapular exanthema to severe blistering reactions. (uniprot.org)
- 95% CI, 4.93 to 116.18).The presence of the HLA-A*3101 allele was associated with carbamazepine-induced hypersensitivity reactions among subjects of Northern European ancestry. (uniprot.org)
- Drug hypersensitivity reactions are initiated by an exposure to a drug at a dose tolerated by a normal person, and they clinically resemble allergy. (scielo.br)
- There are few studies on the prevalence of drug hypersensitivity reactions in the general population, but it may be estimated that about three to four percent of children and more than seven percent of the adult population experience a drug hypersensitivity reaction. (scielo.br)
- These are usually Type IV hypersensitivity (53) reactions, especially nickel and chromate allergy. (alternative-doctor.com)
- Hypersensitivity reactions to betalactams (BLs) are classified as immediate or nonimmediate. (wiley.com)
- The purpose of this review is to describe the hypersensitivity reactions to PPI. (ovid.com)
- Recent findings Hypersensitivity reactions to PPI vary from mild symptoms to life-threatening disorders. (ovid.com)
- Summary A high level of clinical suspicion is critical in the diagnosis of PPI-induced hypersensitivity reactions. (ovid.com)
- Physicians should be aware of the possible hypersensitivity reactions due to PPI and routine/empirical prescription for PPI should only be used when clinically indicated. (ovid.com)
- ABSTRACT: Although nonsteroidal anti-inflammatory drugs (NSAIDs) are one of the most commonly prescribed and consumed drug classes, they are associated with a wide range of adverse effects, including NSAID-induced hypersensitivity reactions (NHRs). (uspharmacist.com)
- NSAID-induced hypersensitivity reactions (NHRs) have been reported in about 0.3% to 6% of the general population and are thought to account for 20% to 30% of all drug-related reactions, placing them second behind antibiotic-associated hypersensitivity reactions. (uspharmacist.com)
- NEW YORK (GenomeWeb News) - The International Serious Adverse Events Consortium has finished enrolling two studies investigating genetic markers linked to drug-induced liver injury and hypersensitivity reactions, and it has launched a new study focused on finding markers of treatment-related inflammatory bowel disease. (genomeweb.com)
Reaction30
- Type 4 hypersensitivity is often called delayed type hypersensitivity as the reaction takes several days to develop. (wikipedia.org)
- Anaphylaxis is the immediate, sometimes fatal hypersensitivity reaction to drugs or serum to which an individual has been previously sensitized. (factmonster.com)
- Hypersensitivity vasculitis is an extreme reaction to a drug, infection, or foreign substance. (medlineplus.gov)
- [ 4 , 5 ] Activation of HLA-B*5701 restricted CD8+ T cells results in the secretion of the inflammatory mediators TNF-alpha and IFN-gamma and induces the delayed-type hypersensitivity reaction. (medscape.com)
- HLA-B*57:01 allele prevalence in HIV-infected North American subjects and the impact of allele testing on the incidence of abacavir-associated hypersensitivity reaction in HLA-B*57:01-negative subjects. (medscape.com)
- Hypersensitivity pneumonitis (HP) is an inflammation of the lung (usually of the very small airways) caused by the body's immune reaction to small air-borne particles. (medicinenet.com)
- Hypersensitivity Vasculitis is an intense immune reaction to a drug, infection or other substance that causes inflammation and damage to blood vessels. (aaaai.org)
- An unusual reaction in muscle in association with a Vitallium plate: a report of possible metal hypersensitivity. (springer.com)
- Zamboni disease (a toxic reaction to nitrogen oxides emitted from an ice-smoothing machine operated in an indoor ice rink) can mimic acute or subacute hypersensitivity pneumonitis. (medscape.com)
- The present invention relates to a method for inhibiting a hypersensitivity reaction in a subject, wherein said method comprises administering an effective amount of chaperonin (10). (freepatentsonline.com)
- 1. A method for inhibiting a hypersensitivity reaction in a subject, wherein said method comprises administering an effective amount of a polypeptide comprising an amino acid sequence selected from the group comprising SEQ ID NO: 3, 4, 7, 9, 11, 13 15 and 17. (freepatentsonline.com)
- 3. The method of claim 1 wherein the hypersensitivity reaction involves the activation of cells selected from the group comprising: basophils, eosinophils, mast cells, neutrophils and lymphocytes. (freepatentsonline.com)
- 4. The method of claim 1, wherein the hypersensitivity reaction involves activation of Toll-like receptor (TLR) signalling. (freepatentsonline.com)
- 5. The method of claim 1, wherein the hypersensitivity reaction involves high levels of eosinophils and immunoglobulin E. (freepatentsonline.com)
- 6. The method of claim 1, wherein the hypersensitivity reaction is an inflammatory reaction. (freepatentsonline.com)
- 7. The method of claim 1, wherein the hypersensitivity reaction is selected from the group comprising: food allergy, dermatitis, allergic conjunctivitis, rhinitis, eczema, anaphylaxis and respiratory diseases associated with airway inflammation. (freepatentsonline.com)
- 9. A method for treating or preventing a hypersensitivity reaction associated disorder in a subject, the method comprising administering to the subject an effective amount of a polypeptide comprising an amino acid sequence selected from the group comprising SEQ ID NO: 3, 4, 7, 9, 11, 13 15 and 17, wherein the polypeptide modulates signalling from a Toll-like receptor. (freepatentsonline.com)
- 16. A composition for treating or preventing a hypersensitivity reaction associated disorder in a subject, the composition comprising an effective amount of a polypeptide comprising an amino acid sequence selected from the group comprising SEQ ID NO: 3, 4, 7, 9, 11, 13 15 and 17, together with an immunosuppressant agent. (freepatentsonline.com)
- Direct trauma and/or delayed type hypersensitivity reaction to nickel may occur from nasal rings and jewelry, facial adornments which as of 2004 are increasingly popular. (yourdictionary.com)
- Hypersensitivity syndrome, a serious systematic reaction to a limited number of drugs, is associated with the reactivation of human herpesvirus 6. (nih.gov)
- Type 1 hypersensitivity is an allergic reaction provoked by reexposure to a specific type of antigen referred to as an allergen. (bionity.com)
- Hypersensitivity pneumonitis starts as an inflammation of the lungs caused by inhaling a foreign substance that then causes an immune reaction. (nationaljewish.org)
- Hypersensitivity pneumonitis (HP), or extrinsic allergic alveolitis, is an allergic lung disease that occurs as the result of an immunologic inflammatory reaction to the inhalation of any of a variety of organic dusts or low molecular weight chemicals with or without systemic manifestations [1,2]. (worldallergy.org)
- A case report of hypersensitivity reaction to human papillomavirus vaccine due to polysorbate 80. (greenmedinfo.com)
- Hypersensitivity to a chemotherapeutic agent is defined as an unforeseen reaction whose signs and symptoms cannot be explained by the known toxicity of the drug [ 29 ]. (hindawi.com)
- Drug allergy is a term that should be used when the drug hypersensitivity reaction is initiated by a specific immunological mechanism. (scielo.br)
- Nutraceuticals for Human Health and Hypersensitivity Reaction. (igi-global.com)
- Drug hypersensitivity syndrome is a severe, unexpected reaction to a medicine, which affects several organ systems at the same time. (dermnetnz.org)
- Drug hypersensitivity syndrome is sometimes also called drug reaction with eosinophilia and systemic symptoms (DRESS), and drug-induced hypersensitivity syndrome (DIHS). (dermnetnz.org)
- Drug hypersensitivity syndrome is a delayed T cell -mediated reaction. (dermnetnz.org)
Dentine hypersensitivity13
- The real cause of dentine hypersensitivity is controversial. (wikipedia.org)
- Dentine hypersensitivity is a sharp, sudden pain arising from the teeth when exposed to touch or hot and cold foods. (cochrane.org)
- Dentine hypersensitivity may be defined as the pain arising from exposed dentine, typically in response to external stimuli, and which cannot be explained by any other form of dental disease. (cochrane.org)
- Poulsen S, Errboe M, Lescay Mevil Y, Glenny A-M. Potassium containing toothpastes for dentine hypersensitivity. (cochrane.org)
- The aim of this study is to compare the efficacy of dentine hypersensitivity reduction using in office paste formula containing nanoHydroxyapatite with the commercially available fluoride (duraphat) and a placebo in treating hypersensitivity in a single visit. (bioportfolio.com)
- Victoria Wilson, David Gillam, Reena Wadia and Siobhan Kelleher will discuss how we can combat dentine hypersensitivity at the Online Dentistry Show this March. (dentistry.co.uk)
- Dentine hypersensitivity is often hard to diagnose. (dentistry.co.uk)
- During this dental webinar several highly regarded clinical experts will explore the many challenges faced in the management of dentine hypersensitivity in a clinical setting. (dentistry.co.uk)
- I am delighted to be working with Biomin to host a presentation on dentine hypersensitivity at the Online Dentistry Show, joined by such influential experts on this subject,' Victoria says. (dentistry.co.uk)
- He has considerable expertise concerning dentine hypersensitivity and periodontal disease. (dentistry.co.uk)
- Dentine hypersensitivity can have a major impact on quality of life - and every patient must be treated as an individual, says David Gillam. (dentistry.co.uk)
- Dentine hypersensitivity (DH) reportedly affects about one person in 10. (dentistry.co.uk)
- Figure 1: What is dentine hypersensitivity? (dentistry.co.uk)
Syndrome23
- [ 4 ] It is thought that a derivative of the abacavir prodrug binds to an antigen-presenting cleft unique to HLA-B*5701, which explains why the drug does not cause a similar hypersensitivity syndrome in carriers of other HLA-B alleles and why compounds similar to abacavir do not react with HLA-B*5701. (medscape.com)
- In particular, rheumatoid arthritis, Sjögren syndrome, and lupus erythematosus may have an associated hypersensitivity vasculitis. (medscape.com)
- Henoch-Schönlein purpura-A syndrome sometimes classified as a hypersensitivity vasculitis, associated with a variety of digestive symptoms, pain in the joints, and kidney involvement. (yourdictionary.com)
- Human herpesvirus 6 encephalitis associated with hypersensitivity syndrome. (nih.gov)
- The clinical features of skin eruptions, high fever, eosinophilia, and atypical lymphocytosis were compatible with drug hypersensitivity syndrome. (nih.gov)
- To our knowledge, this is the first report of human herpesvirus 6 encephalitis associated with hypersensitivity syndrome. (nih.gov)
- While you may never have heard this term, limbic hyperactivity or dysfunction appears to be a foundational core of the dysfunction and challenges associated with multiple chemical sensitivity (MCS), electromagnetic hypersensitivity (EHS), chronic fatigue syndrome (CFS), fibromyalgia and a number of other conditions, and by retraining your limbic system to respond appropriately, symptoms may subside or vanish. (mercola.com)
- Studies of rectal sensory thresholds and compliance in patients with the irritable bowel syndrome have produced conflicting results though there is persistent evidence of rectal hypersensitivity particularly in those with diarrhoea-predominant symptoms. (nih.gov)
- Patients with constipation-predominant irritable bowel syndrome have rectal hypersensitivity and reduced compliance. (nih.gov)
- We postulate that most patients with chronic cough have a single discrete clinical entity: cough hypersensitivity syndrome. (nih.gov)
- It can be used as a diagnostic instrument and demonstrates that chronic cough represents a single coherent entity: cough hypersensitivity syndrome. (nih.gov)
- The report of the NHLBI/ORD workshop [3] stated that "hypersensitivity pneumonitis, also known as extrinsic allergic alveolitis, is a complex health syndrome of varying intensity, clinical presentation, and natural history. (worldallergy.org)
- Electromagnetic hypersensitivity (EHS, microwave syndrome) - Review of mechanisms. (greenmedinfo.com)
- The Electromagnetic Hypersensitivity Syndrome (EHS) sufferer says her problems began in her teenage years, after she suffered a shock when she touched the switch of an electric fire in her bathroom.At first the symptoms were barely noticeable, and at one point she even worked as a secretary for a number of companies, where she had to use a computer. (odditycentral.com)
- The HLA-B*1502 allele has been shown to be strongly correlated with carbamazepine-induced Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS-TEN) in the Han Chinese and other Asian populations but not in European populations.We performed a genomewide association study of samples obtained from 22 subjects with carbamazepine-induced hypersensitivity syndrome, 43 subjects with carbamazepine-induced maculopapular exanthema, and 3987 control subjects, all of European descent. (uniprot.org)
- Thus, many conditions are linked to visceral hypersensitivity like: noncardiac chest pain, nonulcer stomach pain, irritable bowel syndrome, and severe menstrual cramps. (healthcentral.com)
- Drug hypersensitivity syndrome is relatively rare. (dermnetnz.org)
- The risk of drug hypersensitivity syndrome in patients on allopurinol depends on the dose of allopurinol. (dermnetnz.org)
- It can be very difficult to determine the exact cause of drug hypersensitivity syndrome if several medicines have been commenced in preceding weeks. (dermnetnz.org)
- Drug hypersensitivity syndrome usually develops over several days, with onset between 2 and 8 weeks after starting the responsible medicine. (dermnetnz.org)
- The phenytoin (hydantoin) hypersensitivity syndrome is rare but potentially fatal. (bmj.com)
- Dose-dependent side-effects (neurological impairment, gingival hyperplasia and megaloblastic anaemia) soon became apparent but an idiosyncratic hypersensitivity syndrome to phenytoin (and other hydantoins) was first described in 1959. (bmj.com)
- We report a case of unrecognised, fatal, phenytoin hypersensitivity syndrome with characteristic pathological changes in the heart, liver, skin and lymph nodes at autopsy. (bmj.com)
Cutaneous7
- The term cutaneous basophil hypersensitivity (CBH) initially referred to a systemic but evanescent pattern of delayed-onset reactivity in guinea pigs sensitized to protein antigens administered without mycobacterial adjuvants (Richerson et al . (springer.com)
- Askenase, P. W., 1976, Cutaneous basophil hypersensitivity uncovered in the cell transfer of classical tuberculin hypersensitivity, J. Immunol. (springer.com)
- Hypersensitivity vasculitis may present clinically as cutaneous disease only or it may be a cutaneous manifestation of systemic disease. (medscape.com)
- Malignancy accounts for 1-5% of cases of cutaneous hypersensitivity vasculitis. (medscape.com)
- Successful Prevention of Local and Cutaneous Hypersensitivity Rea. (ingentaconnect.com)
- We describe a 23-year-old atopic woman with documented IgE-mediated local and cutaneous hypersensitivity to SF. (ingentaconnect.com)
- Hypersensitivity ('allergic') vasculitis, which is less used now, is a generic term for small vessel cutaneous vasculitis affecting capillaries, venules, or arterioles. (oncologynurseadvisor.com)
Systemic3
- Hypersensitivity vasculitis may look like systemic, necrotizing vasculitis , which can affect blood vessels throughout the body and not just in the skin. (medlineplus.gov)
- Chessman D, Kostenko L, Lethborg T, Purcell AW, Williamson NA, Chen Z. Human leukocyte antigen class I-restricted activation of CD8+ T cells provides the immunogenetic basis of a systemic drug hypersensitivity. (medscape.com)
- Seminal fluid hypersensitivity usually is characterized by postcoital vulvovaginal itching, swelling, redness, with or without systemic signs and symptoms. (ingentaconnect.com)
Chronic14
- Lung changes due to chronic hypersensitivity pneumonitis may be seen on a chest x-ray . (medlineplus.gov)
- What is chronic hypersensitivity pneumonitis? (medicinenet.com)
- Chronic (long-term) hypersensitivity pneumonitis causes lung scarring (fibrosis). (medicinenet.com)
- What are the symptoms of chronic hypersensitivity pneumonitis? (medicinenet.com)
- Differentiating chronic hypersensitivity pneumonitis from idiopathic pulmonary fibrosis is particularly important because the prognosis for the former improves when the offending antigen is identified and eliminated. (medscape.com)
- Subacute and chronic hypersensitivity pneumonitis has been misdiagnosed as asthma , a condition that can also cause cough, dyspnea, and exercise intolerance. (medscape.com)
- Chronic hypersensitivity pneumonitis may be misdiagnosed as anorexia nervosa . (medscape.com)
- Hypersensitivity vasculitis may be acute and self-limited, recurrent, or chronic. (medscape.com)
- The final report could call UIP pattern (with the corresponding level of confidence, with or without ancillary findings suggesting chronic hypersensitivity pneumonitis or collagen vascular disease), other patterns (low or high confidence), specific diagnosis (eg, Langerhans cell histiocytosis, lymphangioleiomyomatosis, malignant epithelial tumors, lymphoproliferative diseases, infections), and no pattern or unclassified fibrosis/inflammation. (thefreedictionary.com)
- The differential diagnosis of cryptogenic organizing pneumonia (BOOP) includes diseases like community-acquired pneumonia, idiopathic interstitial pneumonias, hypersensitivity pneumonitis , chronic eosinophilic pneumonia, and sarcoidosis [1,4]. (thefreedictionary.com)
- Metal hypersensitivity is a cell-mediated immune response that can lead to various diseases, including the granulomatous lung disease called Chronic Beryllium Disease. (nationaljewish.org)
- Aspergillus fumigatus IgG: the test may be used as an adjunct to the diagnosis of hypersensitivity pneumonitis and chronic pulmonary aspergillosis due to Aspergillus fumigatus . (sgh.com.sg)
- We thank Dr. Lacasse and the HP Study Group for their correspondence regarding 'A diagnostic model for chronic hypersensitivity pneumonitis', and appreciate their thoughtful consideration of our work. (bmj.com)
- Visceral hypersensitivity entangles both the internal organs and the central nervous system in a nasty web of chronic pain. (healthcentral.com)
Allergy6
- Hypersensitivity, commonly known as allergy could be defined as an exaggerated response of immune system towards certain allergens present in environment. (wikiversity.org)
- Also searched for Egg Hypersensitivities , Egg allergy , Allergy to eggs and more. (clinicaltrials.gov)
- Disease and disorder research has been conducted in relation to the Hypersensitivity Pathway and Delayed Hypersensitivity, Allergy, Immediate Hypersensitivity, Inflammation, Pain. (novusbio.com)
- The term "allergy" was used in the questionnaire, as it is the most recognized term among the general population, even though "drug hypersensitivity" is probably be more accurate. (scielo.br)
- Delayed dermal hypersensitivity testing (patch test) can generally pinpoint this kind of allergy. (alternative-doctor.com)
- Pharmacovigilance of drug allergy and hypersensitivity using the ENDA-DAHD database and the GA2LEN platform. (wiley.com)
Classification2
- The Gell and Coombs classification of hypersensitivity is the most widely used, and distinguishes four types of immune response which result in bystander tissue damage. (wikipedia.org)
- International Classification of Diseases (ICD) rubrics and codes for Hypersensitivity Pneumonitis (as defined for NORMS). (cdc.gov)
Pneumonitis due3
- Metzger F, Haccuria A, Reboux G, Nolard N, Dalphin JC, De Vuyst P. Hypersensitivity pneumonitis due to molds in a saxophone player. (medscape.com)
- J67.8 - Hypersensitivity pneumonitis due to other organic dusts is a sample topic from the ICD-10-CM . (unboundmedicine.com)
- ICD-10 , www.unboundmedicine.com/icd/view/ICD-10-CM/899854/all/J67_8___Hypersensitivity_pneumonitis_due_to_other_organic_dusts. (unboundmedicine.com)
Dentin hypersensitivity4
- [2] [5] i.e., dentin hypersensitivity is not a true form of allodynia or hyperalgesia . (wikipedia.org)
- Other types of stimuli may also trigger pain in dentin hypersensitivity, including: Thermal - hot and cold drinks and foods, cold air, coolant water jet from a dental instrument. (wikipedia.org)
- Introduction: Dentin hypersensitivity (DH) could be defined as a brief and sharp pain in response to thermical, chemical, tactile and osmotic stimuli, which cannot be attributed to any den. (bioportfolio.com)
- UNO Gel provides rapid and long-lasting relief from dentin hypersensitivity, a common dental complaint that can significantly impair eating, drinking or speaking. (globenewswire.com)
Dentinal hypersensitivity3
- [11] If a negative result for the pain provocation test occurs, no treatment for dentinal hypersensitivity is indicated and another diagnosis should be sought, such as other causes of orofacial pain . (wikipedia.org)
- To assess the efficacy of in-office employed lasers versus other therapeutic approaches, placebo laser, placebo agents or no treatment for relieving pain of dentinal hypersensitivity. (cochrane.org)
- The protocols for the study will be developed as per the guidelines for the design and conduct of clinical trials on dentinal hypersensitivity and in accordance with the Declaration of Helsinki and Guidelines for Good Clinical Practice. (bioportfolio.com)
Esophageal hypersensitivity3
- How can esophageal hypersensitivity cause chest pain? (webmd.com)
- Esophageal hypersensitivity is when the esophagus becomes very painful at the smallest change in pressure or exposure to acid. (webmd.com)
- I did some reading and found something called esophageal hypersensitivity. (healingwell.com)
Vasculitis10
- Hypersensitivity vasculitis most often goes away over time. (medlineplus.gov)
- Call your provider if you have symptoms of hypersensitivity vasculitis. (medlineplus.gov)
- Hypersensitivity syndromes and vasculitis. (medlineplus.gov)
- Hypersensitivity vasculitis, which is usually represented histopathologically as leukocytoclastic vasculitis (LCV), is a term commonly used to denote a small-vessel vasculitis. (medscape.com)
- The internal organs most commonly affected in hypersensitivity vasculitis are the joints, gastrointestinal tract, and kidneys. (medscape.com)
- Overall, hypersensitivity vasculitis has a favorable prognosis, particularly when no internal involvement is present. (medscape.com)
- Hypersensitivity vasculitis is thought to be mediated by immune complex deposition. (medscape.com)
- Overall, however, the exact mechanisms causing hypersensitivity vasculitis remain to be elucidated. (medscape.com)
- Antibiotics are the most common drugs to cause hypersensitivity vasculitis, particularly beta-lactams. (medscape.com)
- Effective management of malignancy can lead to resolution of the hypersensitivity vasculitis. (medscape.com)
Diagnosis of Hypersensit1
- Candida albicans IgG: the test may be used as an adjunct to the diagnosis of hypersensitivity pneumonitis. (sgh.com.sg)
Symptoms11
- Individuals with allergic, or atopic, hypersensitivity form special weak types of antibodies, that cause local tissue damage and such symptoms as hives , hay fever , and asthma . (factmonster.com)
- Symptoms of acute hypersensitivity pneumonitis often occur 4 to 6 hours after you have left the area where the offending substance is found. (medlineplus.gov)
- What are the symptoms of acute hypersensitivity pneumonitis? (medicinenet.com)
- Hypersensitivity pneumonitis (HP) develops after inhalation of many different environmental antigens, causing variable clinical symptoms that often make diagnosis uncertain. (nih.gov)
- The Percentage of Participants With Adjudicated Hypersensitivity Signs/Symptoms, for Each Sugammadex Dose Group and Placebo. (clinicaltrials.gov)
- Hypersensitivity signs/symptoms were systematically collected for each subject by the investigator. (clinicaltrials.gov)
- Suspected cases of hypersensitivity signs/symptoms were sent to the independent Adjudication Committee (comprised of anesthesiologists & allergists/immunologists) for blinded review and determination of adjudicated hypersensitivity &/or anaphylaxis based on expert evaluation of all clinical data from the healthy subject. (clinicaltrials.gov)
- The Adjudication Committee evaluated each case to determine whether the subject's hypersensitivity sign/symptoms fulfilled the definition of anaphylaxis according to the criteria defined by the Symposium on the Definition and Management of Anaphylaxis as described by Sampson et al. (clinicaltrials.gov)
- An Austrian telephone study of a cross section of 526 people by Schroettner & Leitgeb (2008), showed that an increasing number of people suffer from non-specific health symptoms such as headaches, sleep disturbances, difficulties in concentrating etc and attribute their ill health to electromagnetic hypersensitivity (EHS) and electromagnetic pollution. (radiationresearch.org)
- Please if anyone has same symptoms (sour/acid mouth, burning throat & chest, post nasal drip, belching) and was diagnosed with hypersensitivity and was prescribed with amitriptyline (or similar drugs) and managed to get through this, please please share your experience. (healingwell.com)
- And, that's what nearly all such studies have found: "no evidence" that the symptoms are anything but "psychological" in nature, noting that those who claim such hypersensitivity tend to exhibit more obsessive-compulsive, hostile, phobic, and paranoid traits. (nutritionfacts.org)
Acute hypersensitivity pneumonitis3
- What is acute hypersensitivity pneumonitis? (medicinenet.com)
- Acute hypersensitivity pneumonitis tends to occur 4-12 hours after exposure (usually heavy exposure) to the particles. (medicinenet.com)
- Acute hypersensitivity pneumonitis (HP) closely resembles viral or bacterial infections of the lower respiratory tract. (medscape.com)
Case of hypersensitivity3
- We report a case of hypersensitivity myocarditis secondary to clozapine administration that was diagnosed in vivo for the first time through endomyocardial biopsy and was successfully treated with corticosteroids. (redorbit.com)
- Its use, limited by the well-known agranulocytosis risk, has also been associated with severe cardiovascular side effects and sudden death.1-3 Both dilated cardiomyopathy and myocarditis, as result of direct toxicity and drug hypersensitivity, respectively, have been described at autopsy.2,3 We report a case of hypersensitivity myocarditis secondary to clozapine administration diagnosed for the first time in vivo by endomyocardial biopsy and successfully treated with corticosteroids. (redorbit.com)
- An unusual case was published involving a case of hypersensitivity to Canadian goose dropping s. (medicinenet.com)
People with hypersensitivity2
- [7] The most common trigger is cold, [1] with 75% of people with hypersensitivity reporting pain upon application of a cold stimulus. (wikipedia.org)
- Sometimes, treatments used for asthma can help people with hypersensitivity pneumonitis. (medlineplus.gov)
Prevalence2
Antibodies4
- In type 2 hypersensitivity, the antibodies produced by the immune response bind to antigens on the patient's own cell surfaces. (bionity.com)
- Type 3 hypersensitivity occurs when antigens and antibodies are present in roughly equal amounts, causing extensive cross-linking. (bionity.com)
- The Hypersensitivity Pathway complements our catalog of research reagents including antibodies and ELISA kits against OVALBUMIN, BCG, ALB, CD2, CD4. (novusbio.com)
- We have 3105 products for the study of the Hypersensitivity Pathway that can be applied to Chromatin Immunoprecipitation, Flow Cytometry, Western Blot, Immunocytochemistry/Immunofluorescence, Immunohistochemistry from our catalog of antibodies and ELISA kits. (novusbio.com)
Organic dusts3
- Hypersensitivity pneumonia s are a spectrum of disorders that arise from an allergic response to the inhalation of a variety of organic dusts. (britannica.com)
- Hypersensitivity pneumonitis usually occurs in people who work in places where there are high levels of organic dusts, fungus, or molds. (medlineplus.gov)
- It can also cause a condition known as hypersensitivity pneumonitis or HP, a kind of lung inflammation that occurs in people who develop immune system sensitization to inhaled organic dusts. (webwire.com)
Prevent hypersensitivity2
- Indoor Environmental Consultants (IEC) provides mold testing and consulting services to help prevent hypersensitivity pneumonitis (HP) and other health issues. (webwire.com)
- The bioactive polymer used in UNO forms a rapid, protective, dentin integrated layer to prevent hypersensitivity", said Dr. Kishen. (globenewswire.com)
Electro-hypersensitivity1
- The parents of 15-year-old Jenny Fry claim that she suffered from electro-hypersensitivity (EHS), which caused her to suffer tiredness, headaches and bladder problems. (scienceblogs.com)
Visceral hypersensitivity9
- It depends where you have visceral hypersensitivity, in the stomach or osophagus or in bowls. (healingwell.com)
- I had visceral hypersensitivity in the stomach. (healingwell.com)
- Some people are troubled by such a problem called visceral hypersensitivity . (healthcentral.com)
- In the case of visceral hypersensitivity, everything from digestion to urination can become painful. (healthcentral.com)
- 1 All of these conditions are really just a form of visceral hypersensitivity. (healthcentral.com)
- But the diagnosis of visceral hypersensitivity can be difficult because gut pain can be so vague, so hard to pinpoint and so widespread. (healthcentral.com)
- The biggest hallmark of visceral hypersensitivity to watch out for is pain provoked with normally non-painful stimuli. (healthcentral.com)
- Once the diagnosis of visceral hypersensitivity is made, the treatment can be tricky. (healthcentral.com)
- Alternatives to medications are also worth mentioning for the treatment of visceral hypersensitivity, especially those that provoke a relaxation response like meditation, hypnosis or visualization. (healthcentral.com)
Idiopathic1
- What used to be called "Electromagnetic Hypersensitivity" in the medical literature is now called "Idiopathic Environmental Intolerance Attributed to Electromagnetic Fields," an acronym that sounds like something straight out of Old MacDonald's Farm. (nutritionfacts.org)
Sensory5
- Other psychiatric problems that often coexist with tics and tic disorders include learning disorders, impulse control disorders, school phobia, sensory hypersensitivity , and rage attacks. (yourdictionary.com)
- Hoxb8-dependent reinstatement of NECAB2 expression in Necab2-/- mice then demonstrated that spinal and DRG NECAB2 alone could control inflammation-induced sensory hypersensitivity. (jci.org)
- New research shows that patients with fibromyalgia have hypersensitivity to non-painful events based on images of the patients' brains, which show reduced activation in primary sensory regions and increased activation in sensory integration areas. (wiley.com)
- however, the precise mechanisms accounting for the sensory hypersensitivity are not understood. (jci.org)
- These findings also suggest that selective TRPV1 antagonists are potential therapeutic drugs for treating retinoid-induced sensory hypersensitivity. (jci.org)
EPIDEMIOLOGY1
- Epidemiology and causes of hypersensitivity pneumonitis (extrinsic allergic alveolitis) 2005. (medscape.com)
Inflammation of the lungs1
- Hypersensitivity pneumonitis is inflammation of the lungs due to breathing in a foreign substance, usually certain types of dust, fungus, or molds. (medlineplus.gov)
Chest1
- DENVER - The American College of Chest Physicians has published new guidelines for the diagnosis and evaluation of hypersensitivity pneumonitis (HP), an interstitial lung disease characterized by scarring and/or inflammation of the interstitium - the area surrounding the lung's air sacs, blood vessels and airways. (nationaljewish.org)
Mechanisms1
- We will present the characteristics and pathogenetic mechanisms of this hypersensitivity, as well as the basic management options available to date. (hindawi.com)
Subacute2
- Granulomatous lung diseases (eg, tuberculosis , histoplasmosis , coccidiomycosis, sarcoidosis ) can also produce findings similar to those of subacute hypersensitivity pneumonitis. (medscape.com)
- Undoubtedly, subacute hypersensitivity pneumonitis (HP) can resolve completely with immunosuppression. (thefreedictionary.com)
Pathophysiology1
- What is the role of immune hypersensitivity in the pathophysiology of acute urticaria (hives)? (medscape.com)
Immune response1
- Hypersensitivity pneumonitis (HP) is a respiratory disease caused by an exaggerated immune response to inhaled antigens, usually organic in nature. (oncologynurseadvisor.com)