An increased reactivity to specific antigens mediated not by antibodies but by cells.
Immunologically mediated adverse reactions to medicinal substances used legally or illegally.
Altered reactivity to an antigen, which can result in pathologic reactions upon subsequent exposure to that particular antigen.
A common interstitial lung disease caused by hypersensitivity reactions of PULMONARY ALVEOLI after inhalation of and sensitization to environmental antigens of microbial, animal, or chemical sources. The disease is characterized by lymphocytic alveolitis and granulomatous pneumonitis.
A type of acute or chronic skin reaction in which sensitivity is manifested by reactivity to materials or substances coming in contact with the skin. It may involve allergic or non-allergic mechanisms.
Epicutaneous or intradermal application of a sensitizer for demonstration of either delayed or immediate hypersensitivity. Used in diagnosis of hypersensitivity or as a test for cellular immunity.
Hypersensitivity reactions which occur within minutes of exposure to challenging antigen due to the release of histamine which follows the antigen-antibody reaction and causes smooth muscle contraction and increased vascular permeability.
Irritants and reagents for labeling terminal amino acid groups.
An increased sensation of pain or discomfort produced by mimimally noxious stimuli due to damage to soft tissue containing NOCICEPTORS or injury to a peripheral nerve.
A hapten that generates suppressor cells capable of down-regulating the efferent phase of trinitrophenol-specific contact hypersensitivity. (Arthritis Rheum 1991 Feb;34(2):180).
A contact dermatitis due to allergic sensitization to various substances. These substances subsequently produce inflammatory reactions in the skin of those who have acquired hypersensitivity to them as a result of prior exposure.
Immunologic adjuvant and sensitizing agent.
Gastrointestinal disturbances, skin eruptions, or shock due to allergic reactions to allergens in food.
Manifestations of the immune response which are mediated by antigen-sensitized T-lymphocytes via lymphokines or direct cytotoxicity. This takes place in the absence of circulating antibody or where antibody plays a subordinate role.
Substances which reduce or eliminate dentinal sensitivity or the pain associated with a source of stimulus (such as touch, heat, or cold) at the orifice of exposed dentinal tubules causing the movement of tubular fluid that in turn stimulates tooth nerve receptors.
Small antigenic determinants capable of eliciting an immune response only when coupled to a carrier. Haptens bind to antibodies but by themselves cannot elicit an antibody response.
Phenomenon of cell-mediated immunity measured by in vitro inhibition of the migration or phagocytosis of antigen-stimulated LEUKOCYTES or MACROPHAGES. Specific CELL MIGRATION ASSAYS have been developed to estimate levels of migration inhibitory factors, immune reactivity against tumor-associated antigens, and immunosuppressive effects of infectious microorganisms.
Amount of stimulation required before the sensation of pain is experienced.
The outer covering of the body that protects it from the environment. It is composed of the DERMIS and the EPIDERMIS.
An acute hypersensitivity reaction due to exposure to a previously encountered ANTIGEN. The reaction may include rapidly progressing URTICARIA, respiratory distress, vascular collapse, systemic SHOCK, and death.
Skin tests in which the sensitizer is injected.
Adverse cutaneous reactions caused by ingestion, parenteral use, or local application of a drug. These may assume various morphologic patterns and produce various types of lesions.
Substances that are recognized by the immune system and induce an immune reaction.
Transfer of immunity from immunized to non-immune host by administration of serum antibodies, or transplantation of lymphocytes (ADOPTIVE TRANSFER).
Allergic reaction to products containing processed natural rubber latex such as rubber gloves, condoms, catheters, dental dams, balloons, and sporting equipment. Both T-cell mediated (HYPERSENSITIVITY, DELAYED) and IgE antibody-mediated (HYPERSENSITIVITY, IMMEDIATE) allergic responses are possible. Delayed hypersensitivity results from exposure to antioxidants present in the rubber; immediate hypersensitivity results from exposure to a latex protein.
A form of hypersensitivity affecting the respiratory tract. It includes ASTHMA and RHINITIS, ALLERGIC, SEASONAL.
An immunoglobulin associated with MAST CELLS. Overexpression has been associated with allergic hypersensitivity (HYPERSENSITIVITY, IMMEDIATE).
The sensory fibers innervating the viscera.
A protein extracted from boiled culture of tubercle bacilli (MYCOBACTERIUM TUBERCULOSIS). It is used in the tuberculin skin test (TUBERCULIN TEST) for the diagnosis of tuberculosis infection in asymptomatic persons.
Deliberate stimulation of the host's immune response. ACTIVE IMMUNIZATION involves administration of ANTIGENS or IMMUNOLOGIC ADJUVANTS. PASSIVE IMMUNIZATION involves administration of IMMUNE SERA or LYMPHOCYTES or their extracts (e.g., transfer factor, immune RNA) or transplantation of immunocompetent cell producing tissue (thymus or bone marrow).
A common name used for the genus Cavia. The most common species is Cavia porcellus which is the domesticated guinea pig used for pets and biomedical research.
Intense or aching pain that occurs along the course or distribution of a peripheral or cranial nerve.
Act of eliciting a response from a person or organism through physical contact.
An antigen solution emulsified in mineral oil. The complete form is made up of killed, dried mycobacteria, usually M. tuberculosis, suspended in the oil phase. It is effective in stimulating cell-mediated immunity (IMMUNITY, CELLULAR) and potentiates the production of certain IMMUNOGLOBULINS in some animals. The incomplete form does not contain mycobacteria.
Lymphocytes responsible for cell-mediated immunity. Two types have been identified - cytotoxic (T-LYMPHOCYTES, CYTOTOXIC) and helper T-lymphocytes (T-LYMPHOCYTES, HELPER-INDUCER). They are formed when lymphocytes circulate through the THYMUS GLAND and differentiate to thymocytes. When exposed to an antigen, they divide rapidly and produce large numbers of new T cells sensitized to that antigen.
The 31 paired peripheral nerves formed by the union of the dorsal and ventral spinal roots from each spinal cord segment. The spinal nerve plexuses and the spinal roots are also included.
A skin irritant that may cause dermatitis of both primary and allergic types. Contact sensitization with DNCB has been used as a measure of cellular immunity. DNCB is also used as a reagent for the detection and determination of pyridine compounds.
Redness of the skin produced by congestion of the capillaries. This condition may result from a variety of causes.
A disorder with chronic or recurrent colonic symptoms without a clearcut etiology. This condition is characterized by chronic or recurrent ABDOMINAL PAIN, bloating, MUCUS in FECES, and an erratic disturbance of DEFECATION.
Scales, questionnaires, tests, and other methods used to assess pain severity and duration in patients or experimental animals to aid in diagnosis, therapy, and physiological studies.
The production of ANTIBODIES by proliferating and differentiated B-LYMPHOCYTES under stimulation by ANTIGENS.
An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.
An encapsulated lymphatic organ through which venous blood filters.
Antigen-type substances that produce immediate hypersensitivity (HYPERSENSITIVITY, IMMEDIATE).
An albumin obtained from the white of eggs. It is a member of the serpin superfamily.
A dermal inflammatory reaction produced under conditions of antibody excess, when a second injection of antigen produces intravascular antigen-antibody complexes which bind complement, causing cell clumping, endothelial damage, and vascular necrosis.
An evanescent cutaneous reaction occurring when antibody is injected into a local area on the skin and antigen is subsequently injected intravenously along with a dye. The dye makes the rapidly occurring capillary dilatation and increased vascular permeability readily visible by leakage into the reaction site. PCA is a sensitive reaction for detecting very small quantities of antibodies and is also a method for studying the mechanisms of immediate hypersensitivity.
The specific failure of a normally responsive individual to make an immune response to a known antigen. It results from previous contact with the antigen by an immunologically immature individual (fetus or neonate) or by an adult exposed to extreme high-dose or low-dose antigen, or by exposure to radiation, antimetabolites, antilymphocytic serum, etc.
Recirculating, dendritic, antigen-presenting cells containing characteristic racket-shaped granules (Birbeck granules). They are found principally in the stratum spinosum of the EPIDERMIS and are rich in Class II MAJOR HISTOCOMPATIBILITY COMPLEX molecules. Langerhans cells were the first dendritic cell to be described and have been a model of study for other dendritic cells (DCs), especially other migrating DCs such as dermal DCs and INTERSTITIAL DENDRITIC CELLS.
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
A form of alveolitis or pneumonitis due to an acquired hypersensitivity to inhaled avian antigens, usually proteins in the dust of bird feathers and droppings.
An active immunizing agent and a viable avirulent attenuated strain of Mycobacterium tuberculosis, var. bovis, which confers immunity to mycobacterial infections. It is used also in immunotherapy of neoplasms due to its stimulation of antibodies and non-specific immunity.
Sensing of noxious mechanical, thermal or chemical stimuli by NOCICEPTORS. It is the sensory component of visceral and tissue pain (NOCICEPTIVE PAIN).
Morphologic alteration of small B LYMPHOCYTES or T LYMPHOCYTES in culture into large blast-like cells able to synthesize DNA and RNA and to divide mitotically. It is induced by INTERLEUKINS; MITOGENS such as PHYTOHEMAGGLUTININS, and by specific ANTIGENS. It may also occur in vivo as in GRAFT REJECTION.
Pain originating from internal organs (VISCERA) associated with autonomic phenomena (PALLOR; SWEATING; NAUSEA; and VOMITING). It often becomes a REFERRED PAIN.
White blood cells formed in the body's lymphoid tissue. The nucleus is round or ovoid with coarse, irregularly clumped chromatin while the cytoplasm is typically pale blue with azurophilic (if any) granules. Most lymphocytes can be classified as either T or B (with subpopulations of each), or NATURAL KILLER CELLS.
Skin tests in which the sensitizer is applied to a patch of cotton cloth or gauze held in place for approximately 48-72 hours. It is used for the elicitation of a contact hypersensitivity reaction.
An enzyme capable of hydrolyzing highly polymerized DNA by splitting phosphodiester linkages, preferentially adjacent to a pyrimidine nucleotide. This catalyzes endonucleolytic cleavage of DNA yielding 5'-phosphodi- and oligonucleotide end-products. The enzyme has a preference for double-stranded DNA.
Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.
A polysymptomatic condition believed by clinical ecologists to result from immune dysregulation induced by common foods, allergens, and chemicals, resulting in various physical and mental disorders. The medical community has remained largely skeptical of the existence of this "disease", given the plethora of symptoms attributed to environmental illness, the lack of reproducible laboratory abnormalities, and the use of unproven therapies to treat the condition. (From Segen, Dictionary of Modern Medicine, 1992)
A specific immune response elicited by a specific dose of an immunologically active substance or cell in an organism, tissue, or cell.
Granular leukocytes characterized by a relatively pale-staining, lobate nucleus and cytoplasm containing coarse dark-staining granules of variable size and stainable by basic dyes.
A genus of gram-positive bacteria whose spores are round to oval and covered by a sheath.
Substances of fungal origin that have antigenic activity.
A form of alveolitis or pneumonitis due to an acquired hypersensitivity to inhaled antigens associated with farm environment. Antigens in the farm dust are commonly from bacteria actinomycetes (SACCHAROPOLYSPORA and THERMOACTINOMYCES), fungi, and animal proteins in the soil, straw, crops, pelts, serum, and excreta.
Bites and stings inflicted by insects.
A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.
That portion of the electromagnetic spectrum immediately below the visible range and extending into the x-ray frequencies. The longer wavelengths (near-UV or biotic or vital rays) are necessary for the endogenous synthesis of vitamin D and are also called antirachitic rays; the shorter, ionizing wavelengths (far-UV or abiotic or extravital rays) are viricidal, bactericidal, mutagenic, and carcinogenic and are used as disinfectants.
The forcing into the skin of liquid medication, nutrient, or other fluid through a hollow needle, piercing the top skin layer.
Peripheral AFFERENT NEURONS which are sensitive to injuries or pain, usually caused by extreme thermal exposures, mechanical forces, or other noxious stimuli. Their cell bodies reside in the DORSAL ROOT GANGLIA. Their peripheral terminals (NERVE ENDINGS) innervate target tissues and transduce noxious stimuli via axons to the CENTRAL NERVOUS SYSTEM.
Granulated cells that are found in almost all tissues, most abundantly in the skin and the gastrointestinal tract. Like the BASOPHILS, mast cells contain large amounts of HISTAMINE and HEPARIN. Unlike basophils, mast cells normally remain in the tissues and do not circulate in the blood. Mast cells, derived from the bone marrow stem cells, are regulated by the STEM CELL FACTOR.
Elements of limited time intervals, contributing to particular results or situations.
They are oval or bean shaped bodies (1 - 30 mm in diameter) located along the lymphatic system.
Injuries to the PERIPHERAL NERVES.
Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations, or by parent x offspring matings carried out with certain restrictions. All animals within an inbred strain trace back to a common ancestor in the twentieth generation.
4-Imidazoleacrylic acid.
A mixture of the enzymes (streptokinase and streptodornase) produced by hemolytic streptococci. It is used topically on surface lesions and by instillation in closed body cavities to remove clotted blood or fibrinous or purulent accumulations. It is also used as a skin test antigen in evaluating generalized cell-mediated immunodeficiency. (Dorland, 27th ed) EC 3.-.
Substances that augment, stimulate, activate, potentiate, or modulate the immune response at either the cellular or humoral level. The classical agents (Freund's adjuvant, BCG, Corynebacterium parvum, et al.) contain bacterial antigens. Some are endogenous (e.g., histamine, interferon, transfer factor, tuftsin, interleukin-1). Their mode of action is either non-specific, resulting in increased immune responsiveness to a wide variety of antigens, or antigen-specific, i.e., affecting a restricted type of immune response to a narrow group of antigens. The therapeutic efficacy of many biological response modifiers is related to their antigen-specific immunoadjuvanticity.
Drugs that act locally on cutaneous or mucosal surfaces to produce inflammation; those that cause redness due to hyperemia are rubefacients; those that raise blisters are vesicants and those that penetrate sebaceous glands and cause abscesses are pustulants; tear gases and mustard gases are also irritants.
The hearing and equilibrium system of the body. It consists of three parts: the EXTERNAL EAR, the MIDDLE EAR, and the INNER EAR. Sound waves are transmitted through this organ where vibration is transduced to nerve signals that pass through the ACOUSTIC NERVE to the CENTRAL NERVOUS SYSTEM. The inner ear also contains the vestibular organ that maintains equilibrium by transducing signals to the VESTIBULAR NERVE.
A reagent that is used to neutralize peptide terminal amino groups.
Any of the large interior organs in any one of the three great cavities of the body, especially in the abdomen.
A cylindrical column of tissue that lies within the vertebral canal. It is composed of WHITE MATTER and GRAY MATTER.
Diseases in which skin eruptions or rashes are a prominent manifestation. Classically, six such diseases were described with similar rashes; they were numbered in the order in which they were reported. Only the fourth (Duke's disease), fifth (ERYTHEMA INFECTIOSUM), and sixth (EXANTHEMA SUBITUM) numeric designations survive as occasional synonyms in current terminology.
Immunosuppression by the administration of increasing doses of antigen. Though the exact mechanism is not clear, the therapy results in an increase in serum levels of allergen-specific IMMUNOGLOBULIN G, suppression of specific IgE, and an increase in suppressor T-cell activity.
Deliberate prevention or diminution of the host's immune response. It may be nonspecific as in the administration of immunosuppressive agents (drugs or radiation) or by lymphocyte depletion or may be specific as in desensitization or the simultaneous administration of antigen and immunosuppressive drugs.
The outer part of the hearing system of the body. It includes the shell-like EAR AURICLE which collects sound, and the EXTERNAL EAR CANAL, the TYMPANIC MEMBRANE, and the EXTERNAL EAR CARTILAGES.
Dentifrices that are formulated into a paste form. They typically contain abrasives, HUMECTANTS; DETERGENTS; FLAVORING AGENTS; and CARIOSTATIC AGENTS.
Substances elaborated by bacteria that have antigenic activity.
An anticonvulsant used to control grand mal and psychomotor or focal seizures. Its mode of action is not fully understood, but some of its actions resemble those of PHENYTOIN; although there is little chemical resemblance between the two compounds, their three-dimensional structure is similar.
A vascular reaction of the skin characterized by erythema and wheal formation due to localized increase of vascular permeability. The causative mechanism may be allergy, infection, or stress.
The bovine variety of the tubercle bacillus. It is called also Mycobacterium tuberculosis var. bovis.
Non-antibody proteins secreted by inflammatory leukocytes and some non-leukocytic cells, that act as intercellular mediators. They differ from classical hormones in that they are produced by a number of tissue or cell types rather than by specialized glands. They generally act locally in a paracrine or autocrine rather than endocrine manner.
Nonsusceptibility to the invasive or pathogenic effects of foreign microorganisms or to the toxic effect of antigenic substances.
Introduction of therapeutic agents into the spinal region using a needle and syringe.
Allergic reaction to milk (usually cow's milk) or milk products. MILK HYPERSENSITIVITY should be differentiated from LACTOSE INTOLERANCE, an intolerance to milk as a result of congenital deficiency of lactase.
Compounds capable of relieving pain without the loss of CONSCIOUSNESS.
Rare cutaneous eruption characterized by extensive KERATINOCYTE apoptosis resulting in skin detachment with mucosal involvement. It is often provoked by the use of drugs (e.g., antibiotics and anticonvulsants) or associated with PNEUMONIA, MYCOPLASMA. It is considered a continuum of Toxic Epidermal Necrolysis.
Specialized afferent neurons capable of transducing sensory stimuli into NERVE IMPULSES to be transmitted to the CENTRAL NERVOUS SYSTEM. Sometimes sensory receptors for external stimuli are called exteroceptors; for internal stimuli are called interoceptors and proprioceptors.
Nucleosides that have two hydroxy groups removed from the sugar moiety. The majority of these compounds have broad-spectrum antiretroviral activity due to their action as antimetabolites. The nucleosides are phosphorylated intracellularly to their 5'-triphosphates and act as chain-terminating inhibitors of viral reverse transcription.
A histamine H1 antagonist used as an antiemetic, antitussive, for dermatoses and pruritus, for hypersensitivity reactions, as a hypnotic, an antiparkinson, and as an ingredient in common cold preparations. It has some undesired antimuscarinic and sedative effects.
Congenital disorder affecting all bone marrow elements, resulting in ANEMIA; LEUKOPENIA; and THROMBOPENIA, and associated with cardiac, renal, and limb malformations as well as dermal pigmentary changes. Spontaneous CHROMOSOME BREAKAGE is a feature of this disease along with predisposition to LEUKEMIA. There are at least 7 complementation groups in Fanconi anemia: FANCA, FANCB, FANCC, FANCD1, FANCD2, FANCE, FANCF, FANCG, and FANCL. (from Online Mendelian Inheritance in Man,, August 20, 2004)
A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.
Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.
Sensory ganglia located on the dorsal spinal roots within the vertebral column. The spinal ganglion cells are pseudounipolar. The single primary branch bifurcates sending a peripheral process to carry sensory information from the periphery and a central branch which relays that information to the spinal cord or brain.
Increased sensitivity to cutaneous stimulation due to a diminished threshold or an increased response to stimuli.
A relatively small nodular inflammatory lesion containing grouped mononuclear phagocytes, caused by infectious and noninfectious agents.
The space in the eye, filled with aqueous humor, bounded anteriorly by the cornea and a small portion of the sclera and posteriorly by a small portion of the ciliary body, the iris, and that part of the crystalline lens which presents through the pupil. (Cline et al., Dictionary of Visual Science, 4th ed, p109)
A bacteriostatic antibacterial agent that interferes with folic acid synthesis in susceptible bacteria. Its broad spectrum of activity has been limited by the development of resistance. (From Martindale, The Extra Pharmacopoeia, 30th ed, p208)
The major immunoglobulin isotype class in normal human serum. There are several isotype subclasses of IgG, for example, IgG1, IgG2A, and IgG2B.
Neurons in the SPINAL CORD DORSAL HORN whose cell bodies and processes are confined entirely to the CENTRAL NERVOUS SYSTEM. They receive collateral or direct terminations of dorsal root fibers. They send their axons either directly to ANTERIOR HORN CELLS or to the WHITE MATTER ascending and descending longitudinal fibers.
The major interferon produced by mitogenically or antigenically stimulated LYMPHOCYTES. It is structurally different from TYPE I INTERFERON and its major activity is immunoregulation. It has been implicated in the expression of CLASS II HISTOCOMPATIBILITY ANTIGENS in cells that do not normally produce them, leading to AUTOIMMUNE DISEASES.
One of several skin tests to determine past or present tuberculosis infection. A purified protein derivative of the tubercle bacilli, called tuberculin, is introduced into the skin by scratch, puncture, or interdermal injection.
Severe drug eruption characterized by high fever, erythematous rash and inflammation of internal organ(s).
The relatively long-lived phagocytic cell of mammalian tissues that are derived from blood MONOCYTES. Main types are PERITONEAL MACROPHAGES; ALVEOLAR MACROPHAGES; HISTIOCYTES; KUPFFER CELLS of the liver; and OSTEOCLASTS. They may further differentiate within chronic inflammatory lesions to EPITHELIOID CELLS or may fuse to form FOREIGN BODY GIANT CELLS or LANGHANS GIANT CELLS. (from The Dictionary of Cell Biology, Lackie and Dow, 3rd ed.)
Compounds with three aromatic rings in linear arrangement with a SULFUR in the center ring.
Abnormal fluid accumulation in TISSUES or body cavities. Most cases of edema are present under the SKIN in SUBCUTANEOUS TISSUE.
CD4-positive T cells that inhibit immunopathology or autoimmune disease in vivo. They inhibit the immune response by influencing the activity of other cell types. Regulatory T-cells include naturally occurring CD4+CD25+ cells, IL-10 secreting Tr1 cells, and Th3 cells.
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
The relationship between the dose of an administered drug and the response of the organism to the drug.
Loss of the tooth substance by chemical or mechanical processes
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
The observable response an animal makes to any situation.
Antibodies which elicit IMMUNOPRECIPITATION when combined with antigen.
Sensation of making physical contact with objects, animate or inanimate. Tactile stimuli are detected by MECHANORECEPTORS in the skin and mucous membranes.
The serous fluid of ASCITES, the accumulation of fluids in the PERITONEAL CAVITY.
Subset of helper-inducer T-lymphocytes which synthesize and secrete the interleukins IL-4, IL-5, IL-6, and IL-10. These cytokines influence B-cell development and antibody production as well as augmenting humoral responses.
The distal segment of the LARGE INTESTINE, between the SIGMOID COLON and the ANAL CANAL.
Serological reactions in which an antiserum against one antigen reacts with a non-identical but closely related antigen.
A subgroup of TRP cation channels named after vanilloid receptor. They are very sensitive to TEMPERATURE and hot spicy food and CAPSAICIN. They have the TRP domain and ANKYRIN repeats. Selectivity for CALCIUM over SODIUM ranges from 3 to 100 fold.
Immunoglobulin molecules having a specific amino acid sequence by virtue of which they interact only with the ANTIGEN (or a very similar shape) that induced their synthesis in cells of the lymphoid series (especially PLASMA CELLS).
The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.
A diverse group of proteins whose genetic MUTATIONS have been associated with the chromosomal instability syndrome FANCONI ANEMIA. Many of these proteins play important roles in protecting CELLS against OXIDATIVE STRESS.
Injuries to DNA that introduce deviations from its normal, intact structure and which may, if left unrepaired, result in a MUTATION or a block of DNA REPLICATION. These deviations may be caused by physical or chemical agents and occur by natural or unnatural, introduced circumstances. They include the introduction of illegitimate bases during replication or by deamination or other modification of bases; the loss of a base from the DNA backbone leaving an abasic site; single-strand breaks; double strand breaks; and intrastrand (PYRIMIDINE DIMERS) or interstrand crosslinking. Damage can often be repaired (DNA REPAIR). If the damage is extensive, it can induce APOPTOSIS.
Presence of warmth or heat or a temperature notably higher than an accustomed norm.
A recurrent contact dermatitis caused by substances found in the work place.
The etiologic agent of rat leprosy, also known as murine leprosy.
The sensation of cold, heat, coolness, and warmth as detected by THERMORECEPTORS.
The reconstruction of a continuous two-stranded DNA molecule without mismatch from a molecule which contained damaged regions. The major repair mechanisms are excision repair, in which defective regions in one strand are excised and resynthesized using the complementary base pairing information in the intact strand; photoreactivation repair, in which the lethal and mutagenic effects of ultraviolet light are eliminated; and post-replication repair, in which the primary lesions are not repaired, but the gaps in one daughter duplex are filled in by incorporation of portions of the other (undamaged) daughter duplex. Excision repair and post-replication repair are sometimes referred to as "dark repair" because they do not require light.
Serum albumin from cows, commonly used in in vitro biological studies. (From Stedman, 25th ed)
Allergic reaction to eggs that is triggered by the immune system.
Resistance to a disease-causing agent induced by the introduction of maternal immunity into the fetus by transplacental transfer or into the neonate through colostrum and milk.
Any preparations used for cleansing teeth; they usually contain an abrasive, detergent, binder and flavoring agent and may exist in the form of liquid, paste or powder; may also contain medicaments and caries preventives.
White blood cells. These include granular leukocytes (BASOPHILS; EOSINOPHILS; and NEUTROPHILS) as well as non-granular leukocytes (LYMPHOCYTES and MONOCYTES).
Any inflammation of the skin.
A sulfone active against a wide range of bacteria but mainly employed for its actions against MYCOBACTERIUM LEPRAE. Its mechanism of action is probably similar to that of the SULFONAMIDES which involves inhibition of folic acid synthesis in susceptible organisms. It is also used with PYRIMETHAMINE in the treatment of malaria. (From Martindale, The Extra Pharmacopoeia, 30th ed, p157-8)
The number of WHITE BLOOD CELLS per unit volume in venous BLOOD. A differential leukocyte count measures the relative numbers of the different types of white cells.
A water-soluble extractive mixture of sulfated polysaccharides from RED ALGAE. Chief sources are the Irish moss CHONDRUS CRISPUS (Carrageen), and Gigartina stellata. It is used as a stabilizer, for suspending COCOA in chocolate manufacture, and to clarify BEVERAGES.
Proteins released by sensitized LYMPHOCYTES and possibly other cells that inhibit the migration of MACROPHAGES away from the release site. The structure and chemical properties may vary with the species and type of releasing cell.
Contractions of the abdominal muscles upon stimulation of the skin (superficial abdominal reflex) or tapping neighboring bony structures (deep abdominal reflex). The superficial reflex may be weak or absent, for example, after a stroke, a sign of upper (suprasegmental) motor neuron lesions. (Stedman, 25th ed & Best & Taylor's Physiological Basis of Medical Practice, 12th ed, p1073)
Subset of helper-inducer T-lymphocytes which synthesize and secrete interleukin-2, gamma-interferon, and interleukin-12. Due to their ability to kill antigen-presenting cells and their lymphokine-mediated effector activity, Th1 cells are associated with vigorous delayed-type hypersensitivity reactions.
Allergic reaction to peanuts that is triggered by the immune system.
The act of dilating.
Form of passive immunization where previously sensitized immunologic agents (cells or serum) are transferred to non-immune recipients. When transfer of cells is used as a therapy for the treatment of neoplasms, it is called adoptive immunotherapy (IMMUNOTHERAPY, ADOPTIVE).
The application of suitable drug dosage forms to the skin for either local or systemic effects.
Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the LIVER to form the active aldophosphamide. It has been used in the treatment of LYMPHOMA and LEUKEMIA. Its side effect, ALOPECIA, has been used for defleecing sheep. Cyclophosphamide may also cause sterility, birth defects, mutations, and cancer.
A Fanconi anemia complementation group protein that regulates the activities of CYTOCHROME P450 REDUCTASE and GLUTATHIONE S-TRANSFERASE. It is found predominately in the CYTOPLASM, but moves to the CELL NUCLEUS in response to FANCE PROTEIN.
A soluble factor produced by activated T-LYMPHOCYTES that induces the expression of MHC CLASS II GENES and FC RECEPTORS on B-LYMPHOCYTES and causes their proliferation and differentiation. It also acts on T-lymphocytes, MAST CELLS, and several other hematopoietic lineage cells.
A nerve which originates in the lumbar and sacral spinal cord (L4 to S3) and supplies motor and sensory innervation to the lower extremity. The sciatic nerve, which is the main continuation of the sacral plexus, is the largest nerve in the body. It has two major branches, the TIBIAL NERVE and the PERONEAL NERVE.
Any of several BRASSICA species that are commonly called mustard. Brassica alba is white mustard, B. juncea is brown or Chinese mustard, and B. nigra is black, brown, or red mustard. The plant is grown both for mustard seed from which oil is extracted or used as SPICES, and for its greens used as VEGETABLES or ANIMAL FEED. There is no relationship to MUSTARD COMPOUNDS.
Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood.
Agents that are used to treat allergic reactions. Most of these drugs act by preventing the release of inflammatory mediators or inhibiting the actions of released mediators on their target cells. (From AMA Drug Evaluations Annual, 1994, p475)
Serum globulins that migrate to the gamma region (most positively charged) upon ELECTROPHORESIS. At one time, gamma-globulins came to be used as a synonym for immunoglobulins since most immunoglobulins are gamma globulins and conversely most gamma globulins are immunoglobulins. But since some immunoglobulins exhibit an alpha or beta electrophoretic mobility, that usage is in decline.
Oils which are used in industrial or commercial applications.
A broad group of eukaryotic six-transmembrane cation channels that are classified by sequence homology because their functional involvement with SENSATION is varied. They have only weak voltage sensitivity and ion selectivity. They are named after a DROSOPHILA mutant that displayed transient receptor potentials in response to light. A 25-amino-acid motif containing a TRP box (EWKFAR) just C-terminal to S6 is found in TRPC, TRPV and TRPM subgroups. ANKYRIN repeats are found in TRPC, TRPV & TRPN subgroups. Some are functionally associated with TYROSINE KINASE or TYPE C PHOSPHOLIPASES.
An alkylamide found in CAPSICUM that acts at TRPV CATION CHANNELS.
Immunoglobulins produced in a response to FUNGAL ANTIGENS.
Resistance to a disease agent resulting from the production of specific antibodies by the host, either after exposure to the disease or after vaccination.
Granulomatous disorders affecting one or more sites in the respiratory tract.
The distal extremity of the leg in vertebrates, consisting of the tarsus (ANKLE); METATARSUS; phalanges; and the soft tissues surrounding these bones.
Chronic or recurrent colonic disorders without an identifiable structural or biochemical explanation. The widely recognized IRRITABLE BOWEL SYNDROME falls into this category.
The process by which PAIN is recognized and interpreted by the brain.
Dermatologic disorders attendant upon non-dermatologic disease or injury.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
Drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine. Included here are the classical antihistaminics that antagonize or prevent the action of histamine mainly in immediate hypersensitivity. They act in the bronchi, capillaries, and some other smooth muscles, and are used to prevent or allay motion sickness, seasonal rhinitis, and allergic dermatitis and to induce somnolence. The effects of blocking central nervous system H1 receptors are not as well understood.
A mitosporic Tremellales fungal genus whose species usually have a capsule and do not form pseudomycellium. Teleomorphs include Filobasidiella and Fidobasidium.
Conjunctivitis due to hypersensitivity to various allergens.
A non-allergic contact dermatitis caused by prolonged exposure to irritants and not explained by delayed hypersensitivity mechanisms.
An antineoplastic antibiotic produced by Streptomyces caespitosus. It is one of the bi- or tri-functional ALKYLATING AGENTS causing cross-linking of DNA and inhibition of DNA synthesis.
Diseases of the peripheral nerves external to the brain and spinal cord, which includes diseases of the nerve roots, ganglia, plexi, autonomic nerves, sensory nerves, and motor nerves.
The processes triggered by interactions of ANTIBODIES with their ANTIGENS.
Abnormal increase of EOSINOPHILS in the blood, tissues or organs.
Class I human histocompatibility (HLA) surface antigens encoded by more than 30 detectable alleles on locus B of the HLA complex, the most polymorphic of all the HLA specificities. Several of these antigens (e.g., HLA-B27, -B7, -B8) are strongly associated with predisposition to rheumatoid and other autoimmune disorders. Like other class I HLA determinants, they are involved in the cellular immune reactivity of cytolytic T lymphocytes.
Benzene derivatives which are substituted with three nitro groups in any position.
Disease or damage involving the SCIATIC NERVE, which divides into the PERONEAL NERVE and TIBIAL NERVE (see also PERONEAL NEUROPATHIES and TIBIAL NEUROPATHY). Clinical manifestations may include SCIATICA or pain localized to the hip, PARESIS or PARALYSIS of posterior thigh muscles and muscles innervated by the peroneal and tibial nerves, and sensory loss involving the lateral and posterior thigh, posterior and lateral leg, and sole of the foot. The sciatic nerve may be affected by trauma; ISCHEMIA; COLLAGEN DISEASES; and other conditions. (From Adams et al., Principles of Neurology, 6th ed, p1363)
Allergic reaction to tree nuts that is triggered by the immune system.
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
An acquired disorder characterized by recurrent symptoms, referable to multiple organ systems, occurring in response to demonstrable exposure to many chemically unrelated compounds at doses below those established in the general population to cause harmful effects. (Cullen MR. The worker with multiple chemical sensitivities: an overview. Occup Med 1987;2(4):655-61)
An occlusion resulting in overstrain and injury to teeth, periodontal tissue, or other oral structures.
A cytokine produced by a variety of cell types, including T-LYMPHOCYTES; MONOCYTES; DENDRITIC CELLS; and EPITHELIAL CELLS that exerts a variety of effects on immunoregulation and INFLAMMATION. Interleukin-10 combines with itself to form a homodimeric molecule that is the biologically active form of the protein.
Organic compounds that contain the -NCO radical.
The application of drug preparations to the surfaces of the body, especially the skin (ADMINISTRATION, CUTANEOUS) or mucous membranes. This method of treatment is used to avoid systemic side effects when high doses are required at a localized area or as an alternative systemic administration route, to avoid hepatic processing for example.
An absence of warmth or heat or a temperature notably below an accustomed norm.

Emergent immunoregulatory properties of combined glucocorticoid and anti-glucocorticoid steroids in a model of tuberculosis. (1/2860)

In Balb/c mice with pulmonary tuberculosis, there is a switch from a protective Th1-dominated cytokine profile to a non-protective profile with a Th2 component. This switch occurs while the adrenals are undergoing marked hyperplasia. Treatment with the anti-glucocorticoid hormones dehydroepiandrosterone or 3 beta, 17 beta-androstenediol, during the period of adrenal hyperplasia, maintains Th1 dominance and is protective. We investigated the effects of these hormones as therapeutic agents by administering them from day 60, when the switch to the non-protective cytokine profile was already well established. Given at this time (day 60), doses that were protective when given early (from day 0) were rapidly fatal. A physiological dose of the glucocorticoid corticosterone was also rapidly fatal. However when the corticosterone and the anti-glucocorticoid (AED or DHEA) were co-administered, there was protection, with restoration of a Th1-dominated cytokine profile, enhanced DTH responses, and enhanced expression of IL-1 alpha and TNF alpha. Therefore this combination of steroids has an emergent property that is quite unlike that of either type of steroid given alone. It may be possible to exploit the ant-inflammatory properties of glucocorticoids while preserving a Th1 bias, by combining glucocorticoids with DHEA or suitable metabolites.  (+info)

Biophysical characterization of a designed TMV coat protein mutant, R46G, that elicits a moderate hypersensitivity response in Nicotiana sylvestris. (2/2860)

The hypersensitivity resistance response directed by the N' gene in Nicotiana sylvestris is elicited by the tobacco mosaic virus (TMV) coat protein R46G, but not by the U1 wild-type TMV coat protein. In this study, the structural and hydrodynamic properties of R46G and wild-type coat proteins were compared for variations that may explain N' gene elicitation. Circular dichroism spectroscopy reveals no significant secondary or tertiary structural differences between the elicitor and nonelicitor coat proteins. Analytical ultracentrifugation studies, however, do show different concentration dependencies of the weight average sedimentation coefficients at 4 degrees C. Viral reconstitution kinetics at 20 degrees C were used to determine viral assembly rates and as an initial assay of the rate of 20S formation, the obligate species for viral reconstitution. These kinetic results reveal a decreased lag time for reconstitution performed with R46G that initially lack the 20S aggregate. However, experiments performed with 20S initially present reveal no detectable differences indicating that the mechanism of viral assembly is similar for the two coat protein species. Therefore, an increased rate of 20S formation from R46G subunits may explain the differences in the viral reconstitution lag times. The inferred increase in the rate of 20S formation is verified by direct measurement of the 20S boundary as a function of time at 20 degrees C using velocity sedimentation analysis. These results are consistent with the interpretation that there may be an altered size distribution and/or lifetime of the small coat protein aggregates in elicitors that allows N. sylvestris to recognize the invading virus.  (+info)

Vascularity in asthmatic airways: relation to inhaled steroid dose. (3/2860)

BACKGROUND: There is an increase in vascularity in the asthmatic airway. Although inhaled corticosteroids (ICS) are an effective anti-inflammatory treatment in asthma, there are few data on any effects on structural changes. METHODS: Endobronchial biopsy specimens from seven asthmatic subjects not receiving ICS and 15 receiving 200-1500 microg/day beclomethasone dipropionate (BDP) were immunohistochemically stained with an anti-collagen type IV antibody to outline the endothelial basement membrane of the vessels. These were compared with biopsy tissue from 11 non-asthmatic controls (four atopic and seven non-atopic). RESULTS: There was a significant increase in the density of vessels (number of vessels/mm2 of lamina propria) in the asthmatic subjects not on ICS compared with non-asthmatic controls (mean 485 (interquartile range (IQR) 390-597) versus 329 (IQR 248-376) vessels/mm2, p<0.05; 95% CI for the difference 48 to 286). There was no significant difference between asthmatic subjects on ICS and those not on ICS or control subjects in the number of vessels/mm2 (mean 421 (IQR 281-534)). However, patients who received >/=800 microg/day BDP tended to have a reduced number of vessels/mm2 compared with patients not on ICS and those receiving +info)

IL-10-induced anergy in peripheral T cell and reactivation by microenvironmental cytokines: two key steps in specific immunotherapy. (4/2860)

Specific immunotherapy (SIT) is widely used for treatment of allergic diseases and could potentially be applied in other immunological disorders. Induction of specific unresponsiveness (anergy) in peripheral T cells and recovery by cytokines from the tissue microenvironment represent two key steps in SIT with whole allergen or antigenic T cell peptides (PIT). The anergy is directed against the T cell epitopes of the respective antigen and characterized by suppressed proliferative and cytokine responses. It is initiated by autocrine action of IL-10, which is increasingly produced by the antigen-specific T cells. Later in therapy, B cells and monocytes also produce IL-10. The anergic T cells can be reactivated by different cytokines. Whereas IL-15 and IL-2 generate Th1 cytokine profile and an IgG4 antibody response, IL-4 reactivates a Th2 cytokine pattern and IgE antibodies. Increased IL-10 suppresses IgE and enhances IgG4 synthesis, resulting in a decreased antigen-specific IgE:IgG4 ratio, as observed normally in patients after SIT or PIT. The same state of anergy against the major bee venom allergen, phospholipase A2, can be observed in subjects naturally anergized after multiple bee stings. Together, these data demonstrate the pivotal role of autocrine IL-10 in induction of specific T cell anergy and the important participation of the cytokine microenvironment in SIT. Furthermore, knowledge of the mechanisms explaining reasons for success or failure of SIT may enable possible predictive measures of the treatment.  (+info)

Pen c 1, a novel enzymic allergen protein from Penicillium citrinum. Purification, characterization, cloning and expression. (5/2860)

A 33-kDa alkaline serine protease secreted by Penicillium citrinum strain 52-5 is shown to be an allergenic agent in this fungus. The protein, designated Pen c 1, was purified by sequential DEAE-Sepharose and carboxymethyl (CM)-Sepharose chromatographies. Pen c 1 has a molecular mass of 33 kDa and a pI of 7.1. The caseinolytic enzyme activity of this protein was studied. The protein binds to serum IgE from patients allergic to Penicillium citrinum. The cDNA encoding Pen c 1 is 1420 bp in length and contains an open reading frame for a 397-amino-acid polypeptide. Pen c 1 codes for a larger precursor containing a signal peptide, a propeptide and the 33-kDa mature protein. Sequence comparison revealed that Pen c 1 possesses several features in common with the alkaline serine proteases of the subtilisin family. The essential Asp, His, and Ser residues that make up the catalytic triad of serine proteases are well conserved. Northern blots demonstrated that mRNAs transcribed from this gene are present at early stages of culture. The allergen encoded by Pen c 1 gene was expressed in Escherichia coli as a fusion protein bearing an N-terminal histidine-affinity tag. The protein, purified by affinity chromatography with a yield of 130 mg of pure protein per liter of culture, was able to bind to both a monoclonal anti-Pen c 1 antibody and IgE from the serum of patients allergic to Penicillium. Recombinant Pen c 1 can therefore be expressed in E. coli in large quantities and should prove useful as a standardized specific allergen for immuno-diagnosis of atopic disorders. In addition, full caseinolytic enzyme activity could be generated in the purified recombinant protein by sulfonation and renaturation, followed by removal of the affinity tag, indicating that the refolded protein can assume the same conformation as the native protein.  (+info)

In vitro and skin testing for allergy: comparable clinical utility and costs. (6/2860)

Controversy exists concerning the appropriate use of skin testing and in vitro testing for the diagnosis of allergy, particularly inhalant allergy. Earlier comparisons of skin testing and in vitro testing concluded that skin testing had superior accuracy at lower expense. In light of new developments with in vitro allergy testing, however, this issue should be reconsidered. A review of the recent scientific literature indicates that in vitro and skin testing are highly correlated. However, without the existence of an independent gold standard for inhalant allergy, it is not possible to determine which test is more accurate. The accuracy of either test can be compromised if conducted using different protocols or having insufficient quality control. Given their respective trajectories for technological advancement, quantification, and quality control, in vitro testing may offer the more standardized approach. Although the cost per test of in vitro testing remains greater than that of skin testing, the per-patient costs of the two modalities appear to be comparable, given the greater number of allergens typically used in skin testing. In summary, both skin testing and in vitro testing are acceptable as frontline diagnostic tools.  (+info)

Characterization of Epstein-Barr virus (EBV)-infected natural killer (NK) cell proliferation in patients with severe mosquito allergy; establishment of an IL-2-dependent NK-like cell line. (7/2860)

The clinical evidence of a relationship between severe hypersensitivity to mosquito bite (HMB) and clonal expansion of EBV-infected NK cells has been accumulated. In order to clarify the mechanism of EBV-induced NK cell proliferation and its relationship with high incidence of leukaemias or lymphomas in HMB patients, we studied clonally expanded NK cells from three HMB patients and succeeded in establishing an EBV-infected NK-like cell line designated KAI3. Immunoblotting and reverse transcriptase-polymerase chain reaction (RT-PCR) analyses revealed that KAI3 cells as well as infected NK cells exhibited an EBV latent infection type II, where EBV gene expression was limited to EBNA 1 and LMP1. As KAI3 was established by culture with IL-2, IL-2 responsiveness of peripheral blood NK cells from patients was examined. The results represented markedly augmented IL-2-induced IL-2R alpha expression in NK cells. This characteristic property may contribute to the persistent expansion of infected NK cells. However, KAI3 cells as well as the NK cells from patients were not protected from apoptosis induced by either an anti-Fas antibody or NK-sensitive K562 cells. Preserved sensitivity to apoptosis might explain the relatively regulated NK cell numbers in the peripheral blood of the patients. To our knowledge, KAI3 is the first reported NK-like cell line established from patients of severe chronic active EBV infection (SCAEBV) before the onset of leukaemias or lymphomas. KAI3 cells will contribute to the study of EBV persistency in the NK cell environment and its relationship with high incidence of leukaemias or lymphomas in HMB patients.  (+info)

Detection of allergen-induced basophil activation by expression of CD63 antigen using a tricolour flow cytometric method. (8/2860)

In the field of allergy diagnosis, most in vitro functional tests are focused on basophils. Nevertheless, the very small number of circulating basophils limits these experiments and their clinical benefit remains controversial. As flow cytometry is a valuable tool for identifying cell populations, even at low concentrations, we developed a tricolour flow cytometric method for the study of allergen-induced basophil activation. Identification of cells was based both on CD45 expression and on the presence of IgE on the cell surface, since basophils express high-affinity receptors for IgE (Fc epsilon RI). Cell activation upon allergen challenge was assessed by the expression of CD63 antigen on the plasma membrane. Basophil isolation and activation (with the chemotactic peptide formyl-methionyl-leucyl-phenylalanine) were validated in 32 non-allergic patients. In 12 allergic patients, basophil stimulation by a relevant allergen was in most cases positive (10/12). Furthermore a concentration-dependent hook effect was observed. Of the allergic and non-allergic patients, none showed non-specific activation with an irrelevant allergen (specificity 100%). Overall, our preliminary results, even in a small population, suggest that this is a reliable and valuable method for the diagnosis of allergies complementing specific allergen IgE and skin test results. Obviously, additional clinical studies are needed to validate these first results.  (+info)

MELISA stands for Memory Lymphocyte Immunostimulation Assay, a test used to identify metal hypersensitivities. Metal hypersensitivity is a cell-mediated immune response that has a variety of effects. Healthcare professionals may recognize localized signs of metal hypersensitivity such as rashes, hives, and mouth ulcers, but be unaware that metal hypersensitivity also has systemic effects.. Patients with metal hypersensitivity may have numerous symptoms associated with an activated immune system, including chronic fatigue, joint and muscle pain, cognitive impairment, depression, headaches and fibromyalgia. MELISA is a scientifically proven and clinically validated blood test that detects delayed hypersensitivity (type-IV hypersensitivity) to metals, such as mercury, nickel and titanium.. Hypersensitivity to metals also is increasingly recognized as one of the causes of joint replacement failure.. Download Melisa brochure. ...
Background: In addition to the family history of allergy (FH), there is a need o find objective markers of allergy development as early in life as possible in order to focus preventive measurements on high risk infants. Rhinitis problems are common causes to morbidity in adults due to allergic as well as non-allergic mechanisms. Accurate diagnoses are essential for decisions of optimal management of the patients, but in non-allergic rhinitis groups there are no objective tests to verify the diagnosis, if this is needed.. Aims: The primary aim was to evaluate the occurrence of nasal metacromatic (MC) cells during infancy as predictors for allergy development in a group of high risk subjects from birth up to 18 years of age. Additional aims were to find and evaluate nasal markers with ability to differentiate between allergic rhinitis with and without current allergen exposure from normal controls.. Subjects and methods: New-borns (n = 67) with and without family histories of allergy were ...
The role of prenatal diet- and microbiome- derived metabolome in childhood allergy development. Metabolic fingerprinting for allergy prediction
Allergies have increased strikingly in the affluent parts of the world during the last century. The cause of the rapid increase is unknown but several risk factors have been postulated, the main ones relating to reduced microbial exposures and changed diet. In parallel with the increased prevalence of allergies, consumption of saturated fat has declined, while consumption of polyunsaturated fat has risen. The change in dietary fatty acid composition is suggested to influence the risk of developing allergy. This thesis work aimed to investigate whether and how the fatty acid compositions in the body and in the diet affect allergy development. The fatty acid pattern in breast milk and serum was investigated in women with different allergic manifestations. Furthermore, the fatty acid pattern in cord blood was analyzed as a putative factor affecting subsequent development of allergies. In animal models, the effect of diets rich in polyunsaturated fatty acids (PUFAs) on different types of immune responses
The mechanistic factors responsible for the increase in allergic diseases are still not fully understood, but a reduced microbial stimulation seems to be one of the key issues. Research is now aiming at investigating the relationship between the innate immune system, involving the toll-like receptors, and allergy development. Further, the maternal influence on the child, possibly through in utero effects, but also through the breast milk, has shown to be of great importance. This thesis aimed at understanding how the maternal immune system is influenced by early exposures and allergic disease, but also to investigate the consequences of the maternal phenotype on the innate immune system of the developing child.. The Th1/Th2 cytokine pattern in allergic diseases has been extensively studied. Here we were interested in comparing the innate cytokines in allergic and non-allergic women, and to see if the allergic status was influencing the effect of pregnancy differently. We demonstrate that IL-1β, ...
Supplementary Material for: The Impact on Allergy-Related Cells of a Birch Pollen Allergoid, with and without Monophosphoryl Lipid A, in Comparison with the Native Equivalent
The Allergy Risk should display the average risk of a pollen allergy at one glance on a given day (number in the center) and during the day at given times (course around the circle). The intensity of pollination of several allergens, weather parameters and chemical weather data like air pollution and air quality data (ozone, sulphur dioxide, nitrogen dioxide and particulate matter) are taken into account. Hence, the influence of air pollution on pollen allergy sufferers in terms of an augmented reaction to allergens is included into a forecast for the first time. The same applies to temperature, which is a major factor for the development and pollination of plants. Day planning is an important issue for pollen allergy sufferers. The Allergy Risk shows the development of the allergic burden during the day as well as the assessment of the whole day on average at one glance. The Allergy Risk should be considered in coordination with other services of (Medical University of ...
Worldwide, food allergies have been the subject of much debate in recent decades due to what many observe as a dramatic increase in childhood food allergy prevalence, incidence, and severity.1-5 Despite New Zealand having one of the highest prevalences of asthma worldwide, the epidemiology of other atopic diseases, including food allergy, has been poorly characterised.6-8Due to difficulties inherent with the establishment of stable and repeatable measures of food allergy prevalence in the community or in primary care settings, hospital emergency department (ED) presentations for food-related acute allergic reactions have been used in other countries to estimate temporal trends.9-12 Such an approach would seem particularly appropriate in New Zealand given that acute hospital-based secondary care services are free, the hospital presentation data is stored and accessible at both a national and regional level, and each person having contact with health services in New Zealand is assigned a unique ...
Allergies can come in many forms and the symptoms can vary greatly. In general allergy symptoms involve swelling of one kind or another. If your eyes are itchy and red theyre swollen. If your nose is itchy and runny your sinuses are swollen. If you have difficulty breathing and swallowing your throat or air passages may be swollen. According to allergy symptoms can include rashes (skin is swollen), itchiness, hives and in more severe cases vomiting, diarrhea, cramps, abdominal pain and mental confusion & dizziness.. The more severe allergy symptoms may show up as part of a larger reaction called anaphylaxis. Anaphylaxis is a very severe reaction that can be life threatening. Airborne allergens rarely cause anaphylaxis. Most cases are due to food allergies, drug allergies or bug bites/stings according to The first line of defense for allergies is avoidance.. If youre allergy symptoms are brought on by pollen try to keep the doors and windows closed, use air ...
Background: Pregnancy and allergic disease have both been postulated as T-helper 2 (Th2) phenomena. Thus, the increased propensity of allergic mothers to mount Th2-responses might generate favourable effects on the maintenance of pregnancy, but might also be unfavorable, as fetal exposure to a strong Th2 environment could influence the immune development in the offspring to a Th2-like phenotype, favouring IgE production and possibly allergy development later in life. The influence of the intrauterine environment on the immunity and allergy development in the offspring needs to be further investigated.. Aim: The aim of this thesis was to explore the Th1/Th2 balance in allergic and non-allergic women during pregnancy and its influence on the shaping of the Th1/Th2 profile in the neonate and the development of allergic diseases in the offspring.. Material and methods: The study group included 20 women with and 36 women without allergic symptoms followed during pregnancy (gestational week 10-12, ...
Background: Pregnancy and allergic disease have both been postulated as T-helper 2 (Th2) phenomena. Thus, the increased propensity of allergic mothers to mount Th2-responses might generate favourable effects on the maintenance of pregnancy, but might also be unfavorable, as fetal exposure to a strong Th2 environment could influence the immune development in the offspring to a Th2-like phenotype, favouring IgE production and possibly allergy development later in life. The influence of the intrauterine environment on the immunity and allergy development in the offspring needs to be further investigated.. Aim: The aim of this thesis was to explore the Th1/Th2 balance in allergic and non-allergic women during pregnancy and its influence on the shaping of the Th1/Th2 profile in the neonate and the development of allergic diseases in the offspring.. Material and methods: The study group included 20 women with and 36 women without allergic symptoms followed during pregnancy (gestational week 10-12, ...
Allergens are the substances mostly called the sickness of allergy and different allergic reactions. The allergy testing can reveal the symptoms of skin allergy, domestic one, seasonal allergies etc.
Kalyoncu, A. F., Çöplü, L., Selçuk, Z. T., Emri, A. S., Kolaçan, B., Kocabaş, A., αkkoçlcu, A., Erkan, L., şahin, A. and Bariş, Y. I. (1995), Survey of the allergic status of patients with bronchial asthma in Turkey: a multicenter study. Allergy, 50: 451-455. doi: 10.1111/j.1398-9995.1995.tb01177.x ...
An allergy is a hypersensitive disorder of an immune system. Allergy infographic captures all necessary information and statistics and facts on allergies.
Veterinarian-formulated herbal supplement supports the normal texture of your dogs irritated and itchy skin caused by allergies (seasonal, environmental, food), atopy, yeast overgrowth, or other reasons. Supports a healthy immune response to allergens by addressing both the root cause and symptoms.
Latest news and research breakthroughs on Allergy. Last updated on Jan 06, 2018 with over 532 News and research items available on the subject. Freely Download - Allergy News Widget - Page 2
Decorative flowers are known to be a cause of occupational allergy in the floral industry. The allergic manifestations induced by flowers include asthma, rhinoconjunctivitis and urticaria. We present a case of a 55-year-old woman, who has been working for the last 30 years as a gardener with...
About Us - Contact Us Google+ Advertise: 2 million page views Case-based Curriculum of Allergy and Immunology Disclaimer: All opinions expressed here are those of their authors and not of their employer. The information provided here is for educational purposes only and is not intended to provide medical advice. By accessing the web site, the visitors acknowledge that there is no physician-patient relationship between them and the authors. Patient Information ...
Two types of Oreo cookies are being pulled off store shelves after parent company Mondelēz issued a voluntary recall due to allergy risk.
Provocative testing in diagnosing allergies attributed to dust, molds, and pollens; effects on allergies of hydrocarbons and other air pollutants and chemical additives and colorings in food; role of insects; and hyposensitization. Case reports and statistical analyses of results of studies are included. ...
Yeast allergy symptoms in adults - Does anyone out there have a yeast allergy by testing that doesnt have symptoms? Test interpretation. Allergy testing should interpreted along with patient symptoms. Allergy test demonstrates hypersensitivity or potential to develop allergic reactions. Skin testing incorporates immune mechanisms and tissue factors to the positivity of the blood specific ige testing.
Allergic diseases are among the major causes of illness and disability in the United States, affecting as many as 60 million Americans. An allergy is a specific reaction of the bodys immune system to a normally harmless substance, one that does not bother most people. People who have allergies often are sensitive to more than one substance.. Types of allergens that cause allergic reactions include pollens, house dust mites, mold spores, food, latex rubber, insect venom, and medications.. The respiratory symptoms of asthma, which affect approximately 17 million Americans, are often provoked by airborne allergens. Some people with allergy develop asthma, which can be a very serious condition. The symptoms of asthma include coughing, wheezing, and shortness of breath. The shortness of breath is due to a narrowing of the airways in the lungs and to excess mucus production and inflammation. Asthma can be disabling and sometimes fatal ...
Allergies are one of the most common chronic illnesses in North America, affecting more than 25% of adults and children alike. Allergy-related conditions including hay fever, asthma, and eczema are the most common health conditions affecting children. Allergy symptoms can include sneezing, itchy eyes, itchy ears, itchy palate, fatigue, headache, sinus pain, sinus pressure, runny… ...
Infants and babies may suffer from a variety of allergies - even if they are only a few months old. And while skin rashes are most common, some infants and babies suffer from chronic runny or dry noses and may have trouble breathing (which may signify the onset of asthma), or may experience skin reddening after eating foods they are allergic to. And since there is no way for parents to know their child has an allergy until they have an allergic reaction, preventing future attacks is a parents only option. Baby Allergy Causes Baby allergies may last a few months or may last into adulthood, depending on the allergy and the severity of it. If you suspect your baby has had an allergic reaction to food or an airborne allergen such as pet dander or pollen, let your babys physician know so Read more [...] ...
Immunotherapy or hypo sensitization or as they are commonly called allergy shots involves increasing doses of the very allergens to which you are allergic! Over time this allows the body to gradually build up tolerance to the allergen, so the immune system stops reacting to the harmless substance. This, in turn, prevents the release of histamine and other allergy-related substances. Each vaccine is custom-made for each patient to conain liquid extracts of the precise substances (for example, dust mites, pollens, animal dander) that your skin test were positive to. Usually shots are given weekly (sometimes more often). After about seven months the top concentration is reached and over the next few months the time interval is increased to once a month for three to five years. Improvement in allergy symptoms, infections, and asthma is usually apparent in three to six months. About 65% of patients experience good relief (and another 20% some relief) for many years after the injections have ended. ...
We are currently in the peak season of allergy. As a consequence, many people experience allergy reactions. Therefore, every allergist specialist has a lot of people frequently visiting. In addition, COVID-19 is spreading, and the pandemic exacerbates situations. We must therefore more than ever take good care our allergies. You have this article for you if you think that you suffer from any allergy. In this post, we collect fundamental facts on allergy and allergy testing. This post is therefore great for beginners and lay people who havent had an allergy before. Or maybe, you will find this information very helpful if your beloved one or a kid has an allergy. What are the causes? Nobody is certain of the precise cause of allergies. However, the majority of physicians think that allergies are caused by hereditary factors. However, certain environmental variables may be at work here as well. Allergies can arise throughout childhood or later in adulthood. They are erratic. Additionally, if sensitivities
Grape allergy symptoms - How common is grape allergy in us? Very small. For pure grape allergies, the number is extremely small. However, grape allergies are extremely complex owing to folks being poly allergic-both sensitised and allergic to several other different foods, pollens, molds, pesticides.
Allergy symptoms And Treatment method Allergy symptoms can make going outdoors virtually not possible. A lot of victims do not completely understand what treatment method can do.. Heading out and breathing the air is something that a lot of men and women just take for granted. For some likely outside throughout particular times of the yr can cause an allergic response. You can relieve suffering by seeking at the therapies. When you can get outside once again it can make you extremely satisfied.. Some of the most common indicators of allergies depend on what kind of allergy you are suffering with. Some folks have outside allergy symptoms whilst other individuals are allergic to specified meals. Determining your allergy is the initial action in relieving any indicators. You can define what allergy you are suffering with and then appear for therapy.. Even with treatment you will even now have to look at what you expose by yourself to and if a food allergy is existing, it can be a easy as not taking ...
During an allergic attack, these antibodies attach to cells known as mast cells, which are generally concentrated in the lungs, skin, and mucous membranes. Once IgE binds to mast cells, these cells are programmed to release a number of chemicals. One of these chemicals, histamine, opens the blood vessels and causes skin redness and swollen membranes. Histamine causes many of the symptoms associated with allergies but a plethora of additional mediators produced by the body contribute to symptoms patients experience. New research is focused on blocking these additional mediators as well as striving to stall the process of allergy development ...
Are you allergic to certain types of food? You may have a certain structural defect in your skin cells. Scientists have discovered that this defect can contribute to allergy development, including both skin and food allergies, that was typically thought to be a dysfunction of the immune system.
The number of Americans with allergies has grown in all racial, sex, and age groups since the 1980s. According to a survey from the CDC, in 2010 alone there were 11.1 million visits to physician offices with the primary diagnosis of allergic rhinitis, also commonly known as hay fever or seasonal allergies. Moreover there are approximately 50 million Americans that have asthma, hay fever or other allergy-related conditions. News on
We would like to find out whether the effects of worms and their treatment during pregnancy continue as children grow up. So, we are assessing all EMaBS children at the age of nine years for history of allergy-related diseases, for skin prick test responses to allergens, and for any evidence of asthma (Protocol).. ...
There are several treatment options to alleviate seasonal allergies, but they are not effective in treating other medical conditions. Whether this is your first time dealing with allergy symptoms or you experience them every year, its always wise to see an ear, nose and throat doctor (ENT) for diagnosis. They will evaluate your symptoms and collect other important pieces of information to understand whats causing your health issues. Proper diagnosis is the first step towards finding relief, so schedule an appointment with your ENT today!. ...
IgE is a highly elusive antibody class, yet a tremendously powerful elicitor of immune reactions. Despite huge efforts spent on the characterization and understanding of the IgE system many questions remain either unanswered or only marginally addressed. One above all relates to the role of IgE. A common doubt is based on whether IgE mode of action should only be relegated to anti-parasite immunity and allergic manifestations. In search for a hidden role of IgE, reports from several laboratories are described herein in which a natural IgE link to cancer or the experimental redirection of IgE against cancer have been investigated. Epidemiological and investigational studies are trying to elucidate a possible direct intervention of endogenous IgE against cancer, raising thus far no definitive evidence. Conversely, experimental approaches implementing several strategies and engineered IgE formats built up a series of convincing results indicating that cancer might be tackled by the effector functions of
IgE is a highly elusive antibody class, yet a tremendously powerful elicitor of immune reactions. Despite huge efforts spent on the characterization and understanding of the IgE system many questions remain either unanswered or only marginally addressed. One above all relates to the role of IgE. A common doubt is based on whether IgE mode of action should only be relegated to anti-parasite immunity and allergic manifestations. In search for a hidden role of IgE, reports from several laboratories are described herein in which a natural IgE link to cancer or the experimental redirection of IgE against cancer have been investigated. Epidemiological and investigational studies are trying to elucidate a possible direct intervention of endogenous IgE against cancer, raising thus far no definitive evidence. Conversely, experimental approaches implementing several strategies and engineered IgE formats built up a series of convincing results indicating that cancer might be tackled by the effector functions of
I have had CFS and Fibro a long time. I am planning to start allergy shots for dust mites (severe allergy), and was wanting any input from others. On the...
This study examines the association between antibiotic use in the first 6 months of life and the emergence of allergies in children in the first few years of li
We prospectively investigated whether early-life exposure to endotoxins, (1,3)-β-d-glucan and EPS, measured in settled dust from living rooms, plays a role in asthma and atopy development in children up to 10 years of age using data from three European birth cohorts. The birth cohort samples comprised children living in predominantly (sub)-urban areas. The results of our analysis are inconsistent; both positive and negative associations were observed. To the best of our knowledge, the present study is among only a few that have prospectively investigated associations between early exposure to bio-contaminants and respiratory and allergic health outcomes during later childhood, using data which covers different geographical regions in Europe.. Currently, the long-term effects of early exposure to bio-contaminants in relation to health and allergy development at later ages are under investigated, especially for populations living in (sub)-urban environments. Only a few studies can be considered ...
Hello and good day. I would like to ask if it is okay and safe to give my baby antihistamine everyday. I mentioned everyday because she always get allergy rashes everyday everytime she smells strong odor, eat something we are
*Cat eye syndrome-partial Trisomy (22pter-22q11) Ref-Nelson 18th table 422-2. *Cat allergy-Fel d 1 is the major cat allergen,which can cause allergic manifestation in humans.Ref-Nelson 17th page752
External respiration function (VFD) is the main diagnostic method for pathologies of the respiratory system in patients of any age.. The function of external respiration is carried out for those patients who have a genetic predisposition to the development of diseases of the respiratory system, aggravated by allergic manifestations. In addition, the function of external respiration is necessary for people suffering from frequent severe bronchitis and pneumonia, coughing or excruciating shortness of breath, allergic pathologies.. Restrictions in assessing the function of external respiration apply to the category of patients who, due to age, cannot cooperate with a doctor and are not able to fulfill what is asked of them - these are children under the age of five.. The development of a disease such as bronchial asthma is based on an inflammatory phenomenon of a chronic nature, which explains the specific reaction of the respiratory tract to all kinds of effects. The clinical picture of such ...
By Netan Choudhry, MD FRCS(C) and Jennifer George The weather is warm and the flowers are in full bloom; this is the season for sandals, sunscreen and - for many of us - allergies.
Allergies are on the rise these days, especially in children. Nearly half of all kids are now allergic to something, be it food, animals, or plants.
In some people, exposure to certain fungi can lead to asthma or other conditions. This eMedTV segment discusses this topic in detail and provides information on why mold counts are not quite as useful as pollen counts.
Researchers have discovered an interesting fact about the genetic basis of childhood allergic diseases: a child is more likely to have a particular allergy
While in search of the causes of allergies and asthma, a chance discovery has yielded new clues: researchers led by Dr Marcus Peters have ascertained that the enzyme guanylate cyclase in cells lays the foundations for the type of immune response.
Living With Allergy can bring a range of problems. We have information on travelling abroad with an allergy, finding allergy support and allergy in the workplace.
Exposure to cats and dogs does not increase childrens risk of developing allergic disease and may offer protection, a study in Australia suggests.
Our professional team of board-certified physician, nurses and technicians is equipped to handle a comprehensive range of allergic disorders.. ​. You can be assured - we have a commitment to excellence when it comes to the level of care we provide.. ​. ​​ ​. ​. ​. ​. ​. ​. For comprehensive information on allergies and asthma, visit the American College of Allergy, Asthma and Immunology (ACAAI)s ​patient education website. The site provides trusted resources on a variety of topics, including allergy testing and allergy shot (immunotherapy).. ​. ​. ...
A health product manufacturer is recalling a batch of protein shakes because they contain potential allergens not mentioned on the label.
Electromagnetic hypersensitivity[edit]. Main article: Electromagnetic hypersensitivity. Some users of mobile phones and similar ...
Hypersensitivity[edit]. Main article: Dentine hypersensitivity. The use of bleach with extremely low pH levels in the tooth ... Reduced concentrations of hydrogen peroxide cause lower incidences of tooth hypersensitivity.[39] The nanoparticles act as ... there is no evidence to suggest that this is a permanent method to eradicate the issue of hypersensitivity.[51] ...
Hypersensitivity reactions[edit]. Anaphylactoid reactions occur rarely,[4][5][6] but can occur in response to injected as well ... blockers have been assumed as risk factor for the acquisition of contrast medium-induced adverse reactions/hypersensitivity ...
Hypersensitivity reactions can be divided into four types: *Type 1 hypersensitivity includes common immune disorders such as ... Type 4 hypersensitivity, also known as delayed type hypersensitivity, are caused via the over-stimulation of immune cells, ... Hypersensitivity[edit]. The immune system must achieve a balance of sensitivity in order to respond to foreign antigens without ... Other cellular hypersensitivities include cytotoxic T cell mediated auto-immune disease, and a similar phenomenon; transplant ...
Electromagnetic hypersensitivity[edit]. Evidence suggests that the symptoms of electromagnetic hypersensitivity are caused by ... electromagnetic hypersensitivity'): An updated systematic review of provocation studies". Bioelectromagnetics. 31 (1): 1-11. ...
Hypersensitivity reactions[edit]. ALOX5 contributes to non-allergic reactions of the respiratory system and skin such as ... LTC4, LTD4, and LTE4 contribute to allergic airways reactions such as asthma, certain non-allergic hypersensitivity airways ... it may also contribute to hypersensitivity responses of the respiratory system to cold air and possibly even alcohol beverages ... "Classification and practical approach to the diagnosis and management of hypersensitivity to nonsteroidal anti-inflammatory ...
Oral tolerance and hypersensitivity[edit]. See also: Goblet cell § Role in oral tolerance ... Allergy and hypersensitivity reactions in general are traditionally thought of as misguided or excessive reactions by the ... It may also have evolved to prevent hypersensitivity reactions to food proteins.[27] It is of immense immunological importance ... Records from 1829 indicate that American Indians would reduce contact hypersensitivity from poison ivy by consuming leaves of ...
... hypersensitivity; obstinacy, stubbornness; Inability to debate, self-consciousness; narrow-mindedness, bigotry; compulsiveness ...
... hypersensitivity; pressure damage (necrosis) if hard bandages are applied too tightly; perichondritis (inflammation of the ...
... hypersensitivity; pain with pressure and cold, pressure damage (necrosis) from too tightly fitting hard bandages; ...
Smolin G (1971). "Medrysone hypersensitivity. Report of a case". Arch. Ophthalmol. 85 (4): 478-9. doi:10.1001/archopht. ...
Hypersensitivity pneumonitis (HP; also called allergic alveolitis, bagpipe lung, or extrinsic allergic alveolitis, EAA) is an ... Selman, Moisés; Pardo, Annie; King, Talmadge E. (2012-12-14). "Hypersensitivity Pneumonitis". American Journal of Respiratory ... hypersensitivity pneumonitis, lung fibrosis), infections, lung cancer and mesothelioma. These diseases can be caused directly ... Siderosis Silicosis Byssinosis Hypersensitivity pneumonitis Bagassosis Bird fancier's lung Farmer's lung Beckett, W. S. (2000- ...
Hypersensitivity reactions occur in 1.4% of persons treated with dapsone, and can be fatal in medical settings with low ... Hypersensitivity reactions occur in some patients. This reaction may be more frequent in patients receiving multiple-drug ... These toxic reactions may also occur as part of the dapsone hypersensitivity syndrome (a form of SCARs-see above) or dapsone ... Joseph MS (1985). "Hypersensitivity reaction to dapsone. Four case reports". Lepr Rev. 56 (4): 315-20. doi:10.5935/0305- ...
Barrios R. (2008). "Hypersensitivity pneumonitis (extrinsic allergic alveolitis)". Dail and Hammar's Pulmonary Pathology (3rd ... It is one of several types of hypersensitivity pneumonitis caused by different agents that have similar clinical features. ... It is classified as a hypersensitivity pneumonitis (also called extrinsic allergic alveolitis)-an inflammation of the alveoli ... ISBN 978-0-387-72113-2. Peroš-Golubičić T, Sharma OP (2006). "Hypersensitivity pneumonitis". Clinical Atlas of Interstitial ...
Dentine hypersensitivity • Dentinogenesis • Dentinogenesis imperfecta • Dentistry • Dentistry Magazine • Dentistry throughout ...
"Candidiasis Hypersensitivity". National Council Against Health Fraud. Retrieved 18 January 2014. Kumamoto CA (August 2011). " ... "Candidiasis hypersensitivity". Some practitioners of alternative medicine have promoted these purported conditions and sold ...
Haines, AT; Nieboer, E (1988). "Chromium hypersensitivity". In Nriagu, JO; Nieboer, E (eds.). Chromium in the Natural and Human ...
2009). "Hypersensitivity pneumonitis caused by occupational exposure to phytase". Eur Respir J. 33 (6): 1507-09. doi:10.1183/ ... Phytase has been reported to cause hypersensitivity pneumonitis in a human exposed while adding the enzyme to cattle feed. ... Girard M, Cormier Y (2010). "Hypersensitivity pneuomonitis". Current Opinion in Allergy and Clinical Immunology. 10 (2): 99-103 ...
... and Hypersensitivity", Advances in Food Research, Elsevier, pp. 1-76, ISBN 9780120164301, retrieved 2019-05-16 Gunnison, Albert ... F.; Jacobsen, Donald W.; Schwartz, Howard J. (1987). "Sulfite Hypersensitivity. A Critical Review". CRC Critical Reviews in ...
The compound 13-cis retinoic acid was first studied in the 1960s at Roche Laboratories in Switzerland by Werner Bollag as a treatment for skin cancer. Experiments completed in 1971 showed that the compound was likely to be ineffective for cancer and, surprisingly, that it could be useful to treat acne. However, they also showed that the compound was likely to cause birth defects, so in light of the events around thalidomide, Roche abandoned the product. In 1975, Gary Peck and Frank Yoder independently rediscovered the drug's use as a treatment of cystic acne while studying it as a treatment for lamellar ichthyosis, and published that work. Roche resumed work on the drug. In clinical trials, subjects were carefully screened to avoid including women who were or might become pregnant. Roche's New Drug Application for isotretinoin for the treatment of acne included data showing that the drug caused birth defects in rabbits. The FDA approved the application in 1982. Scientists involved in the ...
... is a synthetic form of the isolated major active metabolite of venlafaxine, and is categorized as a serotonin-norepinephrine reuptake inhibitor (SNRI). When most normal metabolizers take venlafaxine, approximately 70% of the dose is metabolized into desvenlafaxine, so the effects of the two drugs are expected to be very similar.[5] It works by blocking the "reuptake" transporters for key neurotransmitters affecting mood, thereby leaving more active neurotransmitters in the synapse. The neurotransmitters affected are serotonin (5-hydroxytryptamine) and norepinephrine (noradrenaline). It is approximately 10 times more potent at inhibiting serotonin uptake than norepinephrine uptake.[6]. ...
It is relatively toxic to humans, and many people have allergic reactions to it.[4] See: Hypersensitivity. Physicians sometimes ... Heidary N, Cohen DE (September 2005). "Hypersensitivity reactions to vaccine components". Dermatitis. 16 (3): 115-20. doi: ...
"Hypersensitivity Reactions, Delayed". EMedicine. Rothenberg ME; Rothenberg, Marc E. (1998). "Eosinophilia". N. Engl. J. Med. ... should not be confused with delayed hypersensitivity Type IV allergic reaction (which takes 48-72 hours to develop and is ...
Sasseville, D (2004). "Hypersensitivity to preservatives". Dermatol Ther. 17 (3): 251-263. doi:10.1111/j.1396-0296.2004.04028.x ...
"Drug Hypersensitivity" (2016). ...
"Lecture 14: Hypersensitivity". Archived from the original on 2009-07-21. Retrieved 2008-09-18. "Allergy & Asthma Disease ... "Chapter 65 - Adverse Reactions to Foods: Respiratory Food Hypersensitivity Reactions" 2008. Elsevier. The Australasian Society ... It is usually classified as type I hypersensitivity.) In response to exposure to these triggers, the bronchi (large airways) ...
Hur, T; Cheng KC; Yang GY (October 1994). "Hypersensitivity pneumonitis: bagassosis". Gaoxiong Yi Xue Ke Xue Za Zhi. 10 (10): ... Bagassosis, an interstitial lung disease, is a type of hypersensitivity pneumonitis attributed to exposure to moldy molasses ( ...
... hypersensitivity pneumonitis (HP); and worsening of pre-existing respiratory problems. Safer cutting fluid formulations provide ...
... type II hypersensitivity). Lymphocytes react not only against thyroid receptors, but also any tissue with cells expressing the ...
EAACI/WHO classifies the syndrome as one of five types of NSAID hypersensitivity or NSAID hypersensitivity reactions. The ... July 2011). "Hypersensitivity to nonsteroidal anti-inflammatory drugs (NSAIDs) - classification, diagnosis and management: ... The symptoms of respiratory reactions in this syndrome are hypersensitivity reactions to NSAIDs rather than the typically ... October 2013). "Classification and practical approach to the diagnosis and management of hypersensitivity to nonsteroidal anti- ...
Drug hypersensitivity caused by alteration of the MHC-presented self-peptide repertoire. David A. Ostrov, Barry J. Grant, Yuri ... 2011) Drug hypersensitivity and human leukocyte antigens of the major histocompatibility complex. Annu Rev Pharmacol Toxicol 52 ... 2008) The roles of drug metabolism in the pathogenesis of T-cell-mediated drug hypersensitivity. Curr Opin Allergy Clin Immunol ... PBMCs from five HLA-B*57:01-positive donors with a clinical history of abacavir hypersensitivity were pulsed for 15 min with ...
Dentin hypersensitivity (abbreviated to DH,[1] or DHS,[2] and also termed sensitive dentin,[3] dentin sensitivity,[4] cervical ... Dentin hypersensitivity is a relatively common condition.[1][5] Due to differences in populations studied and methods of ... Dentin hypersensitivity may affect individuals quality of life.[1] Over time, the dentin-pulp complex may adapt to the ... Low-output lasers are also suggested for dentin hypersensitivity, including GaAlAs lasers and Nd:YAG laser.[9] They are thought ...
... : Age-adjusted death rates by state, U.S. residents age 15 and over, 1996-2005 2009-350 March 2009 ... Hypersensitivity pneumonitis: Number of deaths by state, U.S. residents age 15 and over, 2001-2010 2014-811 September 2014 ... Hypersensitivity pneumonitis: Number of deaths by sex, race, age group, and median age at death, U.S. residents age 15 and over ... Hypersensitivity pneumonitis: Death rates (per million population) by race and sex, U.S. residents age 15 and over, 2005-2014 ...
Type V hypersensitivity. References[edit]. *^ a b c d e f g Kumar, Vinay; Abbas, Abul K.; Aster, Jon C. (2012-05-01). Robbins ... Type 4 hypersensitivity is often called delayed type hypersensitivity as the reaction takes several days to develop. Unlike the ... "Hypersensitivity reactions". Retrieved 2016-05-29.. *^ McDonough, K.; Kress, Y.; Bloom, B. R. (July ... "Hypersensitivity reactions". University of South Carolina School of Medicine - Microbiology and ...
The term cutaneous basophil hypersensitivity (CBH) initially referred to a systemic but evanescent pattern of delayed-onset ... Participation of the basophil in hypersensitivity to antigen-antibody complexes, delayed hypersensitivity and contact allergy. ... Inhibition of delayed hypersensitivity (DH) but not cutaneous basophil hypersensitivity (CBH) in guinea pigs (GP), Fed. Proc. ... Local transfer of delayed hypersensitivity and cutaneous basophil hypersensitivity, J. Immunol. 119: 1987-1993.PubMedGoogle ...
hypersensitivity, heightened response in a body tissue to an antigen or foreign substance. The body normally responds to an ... Serum sickness is a similar but milder hypersensitivity to serum proteins or drugs that occurs several weeks after injection of ... Anaphylaxis is the immediate, sometimes fatal hypersensitivity reaction to drugs or serum to which an individual has been ... Individuals with allergic, or atopic, hypersensitivity form special weak types of antibodies, that cause local tissue damage ...
Hypersensitivity pneumonia: Hypersensitivity pneumonias are a spectrum of disorders that arise from an allergic response to the ... Other articles where Hypersensitivity pneumonia is discussed: pneumonia: ... In pneumonia: Hypersensitivity pneumonia. Hypersensitivity pneumonias are a spectrum of disorders that arise from an allergic ...
Hypersensitivity vasculitis is an extreme reaction to a drug, infection, or foreign substance. It leads to inflammation and ... Hypersensitivity vasculitis, or cutaneous small vessel vasculitis, is caused by:. *An allergic reaction to a drug or other ... Hypersensitivity vasculitis is an extreme reaction to a drug, infection, or foreign substance. It leads to inflammation and ... Hypersensitivity vasculitis may look like systemic, necrotizing vasculitis, which can affect blood vessels throughout the body ...
Unfortunately, drug hypersensitivity with a reaction confined to the heart is difficult to recognize, so that the majority of ... Clozapine-induced hypersensitivity myocarditis should be suspected by psychiatrists and physicians when cardiac dysfunction ... We report a case of hypersensitivity myocarditis secondary to clozapine administration that was diagnosed in vivo for the first ... FIGURE 1. Hypersensitivity myocarditis by clozapine; massive myocardial infiltrates mainly represented by degranulated ...
Hypersensitivity to abacavir is immunologically mediated, driven by conventional MHC-I antigen presentation and activation of ... What causes hypersensitivity to abacavir?. Updated: Dec 07, 2018 * Author: Ali Torkamani, PhD; Chief Editor: Karl S Roth, MD ... Mallal S, Phillips E, Carosi G, Molina JM, Workman C, Tomazic J. HLA-B*5701 screening for hypersensitivity to abacavir. N Engl ... Hypersensitivity to abacavir is immunologically mediated, driven by conventional MHC-I antigen presentation and activation of ...
Hypersensitivity pneumonitis is inflammation of the lungs due to breathing in a foreign substance, usually certain types of ... Examples of hypersensitivity pneumonitis include:. Bird fanciers lung: This is the most common type of hypersensitivity ... Hypersensitivity pneumonitis usually occurs in people who work in places where there are high levels of organic dusts, fungus, ... Symptoms of acute hypersensitivity pneumonitis often occur 4 to 6 hours after you have left the area where the offending ...
Read about hypersensitivity pneumonitis (acute and chronic), and inflammation of the lung caused by bacteria, mold, fungi, and ... Hypersensitivity Pneumonitis. *What is hypersensitivity pneumonitis and what are its causes?. *What is acute hypersensitivity ... Hypersensitivity Pneumonitis - Symptoms What were your symptoms associated with hypersensitivity pneumonitis? Post. View 2 ... home/lungs health center/lungs a-z list/hypersensitivity pneumonitis center /hypersensitivity pneumonitis article ...
Cutaneous Hypersensitivity to Sulphonamides. Br Med J 1943; 2 doi: (Published 31 July ...
Hypersensitivity, commonly known as allergy could be defined as an exaggerated response of immune system towards certain ... Retrieved from "" ...
Metal hypersensitivity and total knee arthroplasty. J Am Acad Orthop Surg. 2016;24(2):106-12.PubMedPubMedCentralCrossRefGoogle ... Hypersensitivity reactions associated with endovascular devices. Contact Dermatitis. 2008;59:7-22.PubMedCrossRefGoogle Scholar ... Total knee arthroplasty in patients with hypersensitivity to metals. Int Orthop. 2014;38(2):329-33.PubMedPubMedCentralCrossRef ... Cutaneous and systemic hypersensitivity reactions to metallic implants. Dermatitis. 2011;22(2):65-79.PubMedGoogle Scholar ...
esophageal hypersensitivity occurs when the esophagus becomes very painful at the smallest change in pressure or exposure to ... How can esophageal hypersensitivity cause chest pain?. ANSWER Esophageal hypersensitivity is when the esophagus becomes very ...
... While you might become enticed to start your current house windows to save a ... Combat Your current Hypersensitivity With your Tips * 1. Combat Your current Hypersensitivity With your TipsWhile you might ... A hypersensitivity check knows as well asoppose your current suspicions.Keep the windows and doors shut down if you suffer ... Pollen gathers up on the body along with flowing hair during the day, and maylead to a hypersensitivity when you make an effort ...
... Analysis by Dr. Joseph Mercola Fact Checked ... "Wi-Fi Refugees" investigates the struggles reported by people who claim to suffer from electromagnetic hypersensitivity ...
Hypersensitivity to polyethylene glycols. J Clin Pharmacol 2013; 53:352.. *Spoerl D, Scherer K, Bircher AJ. Contact urticaria ... Hypersensitivity reactions to systemic glucocorticoids. Author. Rima Rachid, MD. Rima Rachid, MD ... Hypersensitivity reactions to corticosteroids. Clin Rev Allergy Immunol 2014; 47:26.. *Kamm GL, Hagmeyer KO. Allergic-type ... Hypersensitivity to antihistamines. Allergy Asthma Proc 2013; 34:488.. *Rutkowski K, Wagner A. Cetirizine anaphylaxis. Ann ...
In its acute or subacute form, hypersensitivity pneumonitis may be a cause of recurrent pneumonitis. ... Hypersensitivity pneumonitis (HP) refers to a group of disorders caused by a nonatopic immunologic response to an inhaled agent ... Miller MM, Patterson R, Fink JN, Roberts M. Chronic hypersensitivity lung disease with recurrent episodes of hypersensitivity ... encoded search term (Pediatric Hypersensitivity Pneumonitis) and Pediatric Hypersensitivity Pneumonitis What to Read Next on ...
The present invention relates to a method for inhibiting a hypersensitivity reaction in a subject, wherein said method ... An example of a hypersensitivity reaction is an inflammatory reaction. More specifically, examples of a hypersensitivity ... Hypersensitivity reactions are the result of immune responses acting inappropriately and can be provoked by many antigens. One ... Hypersensitivity reactions are the result of immune responses acting inappropriately and can be provoked by many antigens. One ...
There are many potential causes of hypersensitivity vasculitis; however, up to 50% of cases are idiopathic. ... Hypersensitivity vasculitis, which is usually represented histopathologically as leukocytoclastic vasculitis (LCV), is a term ... encoded search term (Hypersensitivity Vasculitis) and Hypersensitivity Vasculitis What to Read Next on Medscape. Related ... Several studies from Spain have been conducted on hypersensitivity vasculitis. [9, 10, 11, 12, 13] Hypersensitivity vasculitis ...
Hypersensitivity. Some individuals are hypersensitive to fluoride. According to the Physicians Desk Reference:. "In ... Case Reports of Hypersensitivity to Ingested Fluorides. In the 1950s, the renowned allergist George Waldbott discovered that ... Hypersensitivity. "In hypersensitive individuals, fluorides occasionally cause skin eruptions such as atopic dermatitis, eczema ... These hypersensitivity reactions usually disappear promptly after discontinuation of the fluoride.". Hypersensitive reactions ...
Delayed Hypersensitivity Reactions at eMedicine Kumar, Vinay; Abbas, Abul K.; Aster, Jon C., eds. (2014). "Hypersensitivity: ... Hypersensitivity (also called hypersensitivity reaction or intolerance) refers to undesirable reactions produced by the normal ... Hypersensitivity reactions require a pre-sensitized (immune) state of the host. The Gell and Coombs classification of ... ISBN 978-1-4160-2973-1. Rajan, T.V. (2003). "The Gell-Coombs classification of hypersensitivity reactions: A re-interpretation ...
Hypersensitivity pneumonitis. J Allergy Clin Immunol 1984;74: 1-9.. *Patel AM, Ryu JH, Reed CE. Hypersensitivity pneumonitis: ... Hypersensitivity pneumonitis. AJR Am J Roentgenol 2000;174:1061-1066.. *Lacasse Y, Selman M, Costabel U, Dalphin JC, Morell M, ... HYPERSENSITIVITY PNEUMONITIS IN CHILDREN. Because pediatric cases of HP are rarely recognized or reported, knowledge is limited ... Hypersensitivity pneumonitis in man: light- and electron-microscopic studies of 18 lung biopsies. Am J Pathol 1983;110:275-289. ...
... plural hypersensitivities) 1. any heightened immune response to an antigen; an allergy Origin hyper- +Ž sensitivity... ... Direct trauma and/or delayed type hypersensitivity reaction to nickel may occur from nasal rings and jewelry, facial adornments ... Henoch-Schönlein purpura-A syndrome sometimes classified as a hypersensitivity vasculitis, associated with a variety of ... Hypersensitivity. (n.d.). In YourDictionary. Retrieved from ...
Tag: candida hypersensitivity. Basic ScienceScience and Medicine. Of Mice and Men…and Coconut Oil. Editors note: This post is ...
Re: Hypersensitivity yes I feel silly tho just a soft touch is enough to set me off I find if I bumb myself soft or do ... Re: Hypersensitivity Sorry I thought I was been clear yes its fits in with fibro and no your not alone at all we are here and ... Re: Hypersensitivity yes yes and yes! I feel terrible that it hurts when my kids and husband hug me but i cant stand it. it ... Re: Hypersensitivity No you are not crazy alone or too sensitive.I think that is part of the makeup of fibro.Our nerve endings, ...
Hypersensitivity pneumonitis synonyms, Hypersensitivity pneumonitis pronunciation, Hypersensitivity pneumonitis translation, ... English dictionary definition of Hypersensitivity pneumonitis. adj. 1. Highly or excessively sensitive. 2. Responding ... hypersensitivity. (redirected from Hypersensitivity pneumonitis). Also found in: Thesaurus, Medical, Acronyms, Encyclopedia, ... cryaesthesia, cryesthesia - hypersensitivity to cold. hypersensitivity reaction - an inappropriate and excessive reaction to an ...
  • Clinical data suggest that many such reactions involve immune mechanisms, and genetic association studies have identified strong linkages between drug hypersensitivity reactions to several drugs and specific HLA alleles. (
  • The danger model, which is in principle compatible with other models, states that danger signals other than the drug itself (e.g., chemical, physical, or viral stress) are required to overcome immune tolerance barriers that otherwise suppress drug hypersensitivity reactions ( 7 ). (
  • Hetherington S, McGuirk S, Powell G, Cutrell A, Naderer O, Spreen B. Hypersensitivity reactions during therapy with the nucleoside reverse transcriptase inhibitor abacavir. (
  • Hypersensitivity reactions to hip and knee implant components are well documented in the literature but remain uncommon. (
  • Cutaneous and systemic hypersensitivity reactions to metallic implants. (
  • Make use of supporters or a central atmosphere program to flow theenvironment alternatively, which should minimize the allergic reactions.In the event that hypersensitivity tend to be leading to onto your nose for you to tricklecontinually, you may experience chafing, soreness and ache close to your nasal passages.Using document flesh to prevent drains could make this issue worse. (
  • However, injected, infused, or orally administered systemic glucocorticoids have been associated with immediate hypersensitivity (allergic) reactions, including life-threatening anaphylaxis. (
  • This topic will review the epidemiology, clinical manifestations, diagnosis, and management of hypersensitivity reactions to systemic glucocorticoids. (
  • Hypersensitivity reactions to systemic glucocorticoids are rare, although the exact incidence is unknown. (
  • These hypersensitivity reactions usually disappear promptly after discontinuation of the fluoride. (
  • Hypersensitivity reactions to chemotherapy, although rare, have been reported with most chemotherapy drugs. (
  • The doctor will begin by ruling out such other possible diagnoses as bacterial or viral infections, collagen vascular disease, hypersensitivity reactions, and malignant tumors. (
  • Hypersensitivity (also called hypersensitivity reaction or intolerance) refers to undesirable reactions produced by the normal immune system, including allergies and autoimmunity. (
  • Hypersensitivity reactions require a pre-sensitized (immune) state of the host. (
  • Hypersensitivity refers to undesirable (damaging, discomfort-producing and sometimes fatal) reactions produced by the normal immune system. (
  • Although hypersensitivity to glycopeptides is rare, both immune-mediated and delayed reactions have been reported in the literature. (
  • We describe the various types of glycopeptide hypersensitivity reactions associated with glycopeptides and lipoglycopeptides, including IgE-mediated reactions, RMS, and linear immunoglobulin A bullous dermatosis, as well as describe cross-reactivity with other glycopeptides. (
  • Prevalence of hypersensitivity reactions in children associated with acetaminophen. (
  • Chemotherapeutic agents may induce hypersensitivity reactions in pediatric patients. (
  • Their extensive use over the last decade has led to a significant increase in the incidence of hypersensitivity reactions, which are defined as unforeseen reactions whose signs and symptoms cannot be explained by the known toxicity of these drugs. (
  • Hypersensitivity reactions in patients receiving cisplatin were first described in the 1970s in patients who had been retreated with the drug [ 31 ]. (
  • The aim of this paper is to provide recent data concerning hypersensitivity reactions to platinum-containing chemotherapy agents. (
  • Extensive use of platinum compounds in chemotherapy during the last decade has led to a significant increase in the incidence of hypersensitivity reactions (Table 1 ). (
  • Using a controlled, single-blind challenge method, pretreatment with intravaginal 4% cromalyn sodium in a water-based cream completely blocked both local and cutaneous immediate hypersensitivity reactions to SF in this highly sensitive patient. (
  • HLA-A*3101 and carbamazepine-induced hypersensitivity reactions in Europeans. (
  • Carbamazepine causes various forms of hypersensitivity reactions, ranging from maculopapular exanthema to severe blistering reactions. (
  • 95% CI, 4.93 to 116.18).The presence of the HLA-A*3101 allele was associated with carbamazepine-induced hypersensitivity reactions among subjects of Northern European ancestry. (
  • Drug hypersensitivity reactions are initiated by an exposure to a drug at a dose tolerated by a normal person, and they clinically resemble allergy. (
  • There are few studies on the prevalence of drug hypersensitivity reactions in the general population, but it may be estimated that about three to four percent of children and more than seven percent of the adult population experience a drug hypersensitivity reaction. (
  • These are usually Type IV hypersensitivity (53) reactions, especially nickel and chromate allergy. (
  • Hypersensitivity reactions to betalactams (BLs) are classified as immediate or nonimmediate. (
  • The purpose of this review is to describe the hypersensitivity reactions to PPI. (
  • Recent findings Hypersensitivity reactions to PPI vary from mild symptoms to life-threatening disorders. (
  • Summary A high level of clinical suspicion is critical in the diagnosis of PPI-induced hypersensitivity reactions. (
  • Physicians should be aware of the possible hypersensitivity reactions due to PPI and routine/empirical prescription for PPI should only be used when clinically indicated. (
  • ABSTRACT: Although nonsteroidal anti-inflammatory drugs (NSAIDs) are one of the most commonly prescribed and consumed drug classes, they are associated with a wide range of adverse effects, including NSAID-induced hypersensitivity reactions (NHRs). (
  • NSAID-induced hypersensitivity reactions (NHRs) have been reported in about 0.3% to 6% of the general population and are thought to account for 20% to 30% of all drug-related reactions, placing them second behind antibiotic-associated hypersensitivity reactions. (
  • NEW YORK (GenomeWeb News) - The International Serious Adverse Events Consortium has finished enrolling two studies investigating genetic markers linked to drug-induced liver injury and hypersensitivity reactions, and it has launched a new study focused on finding markers of treatment-related inflammatory bowel disease. (
  • Type 4 hypersensitivity is often called delayed type hypersensitivity as the reaction takes several days to develop. (
  • Anaphylaxis is the immediate, sometimes fatal hypersensitivity reaction to drugs or serum to which an individual has been previously sensitized. (
  • Hypersensitivity vasculitis is an extreme reaction to a drug, infection, or foreign substance. (
  • [ 4 , 5 ] Activation of HLA-B*5701 restricted CD8+ T cells results in the secretion of the inflammatory mediators TNF-alpha and IFN-gamma and induces the delayed-type hypersensitivity reaction. (
  • HLA-B*57:01 allele prevalence in HIV-infected North American subjects and the impact of allele testing on the incidence of abacavir-associated hypersensitivity reaction in HLA-B*57:01-negative subjects. (
  • Hypersensitivity pneumonitis (HP) is an inflammation of the lung (usually of the very small airways) caused by the body's immune reaction to small air-borne particles. (
  • Hypersensitivity Vasculitis is an intense immune reaction to a drug, infection or other substance that causes inflammation and damage to blood vessels. (
  • An unusual reaction in muscle in association with a Vitallium plate: a report of possible metal hypersensitivity. (
  • Zamboni disease (a toxic reaction to nitrogen oxides emitted from an ice-smoothing machine operated in an indoor ice rink) can mimic acute or subacute hypersensitivity pneumonitis. (
  • The present invention relates to a method for inhibiting a hypersensitivity reaction in a subject, wherein said method comprises administering an effective amount of chaperonin (10). (
  • 1. A method for inhibiting a hypersensitivity reaction in a subject, wherein said method comprises administering an effective amount of a polypeptide comprising an amino acid sequence selected from the group comprising SEQ ID NO: 3, 4, 7, 9, 11, 13 15 and 17. (
  • 3. The method of claim 1 wherein the hypersensitivity reaction involves the activation of cells selected from the group comprising: basophils, eosinophils, mast cells, neutrophils and lymphocytes. (
  • 4. The method of claim 1, wherein the hypersensitivity reaction involves activation of Toll-like receptor (TLR) signalling. (
  • 5. The method of claim 1, wherein the hypersensitivity reaction involves high levels of eosinophils and immunoglobulin E. (
  • 6. The method of claim 1, wherein the hypersensitivity reaction is an inflammatory reaction. (
  • 7. The method of claim 1, wherein the hypersensitivity reaction is selected from the group comprising: food allergy, dermatitis, allergic conjunctivitis, rhinitis, eczema, anaphylaxis and respiratory diseases associated with airway inflammation. (
  • 9. A method for treating or preventing a hypersensitivity reaction associated disorder in a subject, the method comprising administering to the subject an effective amount of a polypeptide comprising an amino acid sequence selected from the group comprising SEQ ID NO: 3, 4, 7, 9, 11, 13 15 and 17, wherein the polypeptide modulates signalling from a Toll-like receptor. (
  • 16. A composition for treating or preventing a hypersensitivity reaction associated disorder in a subject, the composition comprising an effective amount of a polypeptide comprising an amino acid sequence selected from the group comprising SEQ ID NO: 3, 4, 7, 9, 11, 13 15 and 17, together with an immunosuppressant agent. (
  • Direct trauma and/or delayed type hypersensitivity reaction to nickel may occur from nasal rings and jewelry, facial adornments which as of 2004 are increasingly popular. (
  • Hypersensitivity syndrome, a serious systematic reaction to a limited number of drugs, is associated with the reactivation of human herpesvirus 6. (
  • Type 1 hypersensitivity is an allergic reaction provoked by reexposure to a specific type of antigen referred to as an allergen. (
  • Hypersensitivity pneumonitis starts as an inflammation of the lungs caused by inhaling a foreign substance that then causes an immune reaction. (
  • Hypersensitivity pneumonitis (HP), or extrinsic allergic alveolitis, is an allergic lung disease that occurs as the result of an immunologic inflammatory reaction to the inhalation of any of a variety of organic dusts or low molecular weight chemicals with or without systemic manifestations [1,2]. (
  • A case report of hypersensitivity reaction to human papillomavirus vaccine due to polysorbate 80. (
  • Hypersensitivity to a chemotherapeutic agent is defined as an unforeseen reaction whose signs and symptoms cannot be explained by the known toxicity of the drug [ 29 ]. (
  • Drug allergy is a term that should be used when the drug hypersensitivity reaction is initiated by a specific immunological mechanism. (
  • Nutraceuticals for Human Health and Hypersensitivity Reaction. (
  • Drug hypersensitivity syndrome is a severe, unexpected reaction to a medicine, which affects several organ systems at the same time. (
  • Drug hypersensitivity syndrome is sometimes also called drug reaction with eosinophilia and systemic symptoms (DRESS), and drug-induced hypersensitivity syndrome (DIHS). (
  • Drug hypersensitivity syndrome is a delayed T cell -mediated reaction. (
  • The real cause of dentine hypersensitivity is controversial. (
  • Dentine hypersensitivity is a sharp, sudden pain arising from the teeth when exposed to touch or hot and cold foods. (
  • Dentine hypersensitivity may be defined as the pain arising from exposed dentine, typically in response to external stimuli, and which cannot be explained by any other form of dental disease. (
  • Poulsen S, Errboe M, Lescay Mevil Y, Glenny A-M. Potassium containing toothpastes for dentine hypersensitivity. (
  • The aim of this study is to compare the efficacy of dentine hypersensitivity reduction using in office paste formula containing nanoHydroxyapatite with the commercially available fluoride (duraphat) and a placebo in treating hypersensitivity in a single visit. (
  • Victoria Wilson, David Gillam, Reena Wadia and Siobhan Kelleher will discuss how we can combat dentine hypersensitivity at the Online Dentistry Show this March. (
  • Dentine hypersensitivity is often hard to diagnose. (
  • During this dental webinar several highly regarded clinical experts will explore the many challenges faced in the management of dentine hypersensitivity in a clinical setting. (
  • I am delighted to be working with Biomin to host a presentation on dentine hypersensitivity at the Online Dentistry Show, joined by such influential experts on this subject,' Victoria says. (
  • He has considerable expertise concerning dentine hypersensitivity and periodontal disease. (
  • Dentine hypersensitivity can have a major impact on quality of life - and every patient must be treated as an individual, says David Gillam. (
  • Dentine hypersensitivity (DH) reportedly affects about one person in 10. (
  • Figure 1: What is dentine hypersensitivity? (
  • [ 4 ] It is thought that a derivative of the abacavir prodrug binds to an antigen-presenting cleft unique to HLA-B*5701, which explains why the drug does not cause a similar hypersensitivity syndrome in carriers of other HLA-B alleles and why compounds similar to abacavir do not react with HLA-B*5701. (
  • In particular, rheumatoid arthritis, Sjögren syndrome, and lupus erythematosus may have an associated hypersensitivity vasculitis. (
  • Henoch-Schönlein purpura-A syndrome sometimes classified as a hypersensitivity vasculitis, associated with a variety of digestive symptoms, pain in the joints, and kidney involvement. (
  • Human herpesvirus 6 encephalitis associated with hypersensitivity syndrome. (
  • The clinical features of skin eruptions, high fever, eosinophilia, and atypical lymphocytosis were compatible with drug hypersensitivity syndrome. (
  • To our knowledge, this is the first report of human herpesvirus 6 encephalitis associated with hypersensitivity syndrome. (
  • While you may never have heard this term, limbic hyperactivity or dysfunction appears to be a foundational core of the dysfunction and challenges associated with multiple chemical sensitivity (MCS), electromagnetic hypersensitivity (EHS), chronic fatigue syndrome (CFS), fibromyalgia and a number of other conditions, and by retraining your limbic system to respond appropriately, symptoms may subside or vanish. (
  • Studies of rectal sensory thresholds and compliance in patients with the irritable bowel syndrome have produced conflicting results though there is persistent evidence of rectal hypersensitivity particularly in those with diarrhoea-predominant symptoms. (
  • Patients with constipation-predominant irritable bowel syndrome have rectal hypersensitivity and reduced compliance. (
  • We postulate that most patients with chronic cough have a single discrete clinical entity: cough hypersensitivity syndrome. (
  • It can be used as a diagnostic instrument and demonstrates that chronic cough represents a single coherent entity: cough hypersensitivity syndrome. (
  • The report of the NHLBI/ORD workshop [3] stated that "hypersensitivity pneumonitis, also known as extrinsic allergic alveolitis, is a complex health syndrome of varying intensity, clinical presentation, and natural history. (
  • Electromagnetic hypersensitivity (EHS, microwave syndrome) - Review of mechanisms. (
  • The Electromagnetic Hypersensitivity Syndrome (EHS) sufferer says her problems began in her teenage years, after she suffered a shock when she touched the switch of an electric fire in her bathroom.At first the symptoms were barely noticeable, and at one point she even worked as a secretary for a number of companies, where she had to use a computer. (
  • The HLA-B*1502 allele has been shown to be strongly correlated with carbamazepine-induced Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS-TEN) in the Han Chinese and other Asian populations but not in European populations.We performed a genomewide association study of samples obtained from 22 subjects with carbamazepine-induced hypersensitivity syndrome, 43 subjects with carbamazepine-induced maculopapular exanthema, and 3987 control subjects, all of European descent. (
  • Thus, many conditions are linked to visceral hypersensitivity like: noncardiac chest pain, nonulcer stomach pain, irritable bowel syndrome, and severe menstrual cramps. (
  • Drug hypersensitivity syndrome is relatively rare. (
  • The risk of drug hypersensitivity syndrome in patients on allopurinol depends on the dose of allopurinol. (
  • It can be very difficult to determine the exact cause of drug hypersensitivity syndrome if several medicines have been commenced in preceding weeks. (
  • Drug hypersensitivity syndrome usually develops over several days, with onset between 2 and 8 weeks after starting the responsible medicine. (
  • The phenytoin (hydantoin) hypersensitivity syndrome is rare but potentially fatal. (
  • Dose-dependent side-effects (neurological impairment, gingival hyperplasia and megaloblastic anaemia) soon became apparent but an idiosyncratic hypersensitivity syndrome to phenytoin (and other hydantoins) was first described in 1959. (
  • We report a case of unrecognised, fatal, phenytoin hypersensitivity syndrome with characteristic pathological changes in the heart, liver, skin and lymph nodes at autopsy. (
  • The term cutaneous basophil hypersensitivity (CBH) initially referred to a systemic but evanescent pattern of delayed-onset reactivity in guinea pigs sensitized to protein antigens administered without mycobacterial adjuvants (Richerson et al . (
  • Askenase, P. W., 1976, Cutaneous basophil hypersensitivity uncovered in the cell transfer of classical tuberculin hypersensitivity, J. Immunol. (
  • Hypersensitivity vasculitis may present clinically as cutaneous disease only or it may be a cutaneous manifestation of systemic disease. (
  • Malignancy accounts for 1-5% of cases of cutaneous hypersensitivity vasculitis. (
  • Successful Prevention of Local and Cutaneous Hypersensitivity Rea. (
  • We describe a 23-year-old atopic woman with documented IgE-mediated local and cutaneous hypersensitivity to SF. (
  • Hypersensitivity ('allergic') vasculitis, which is less used now, is a generic term for small vessel cutaneous vasculitis affecting capillaries, venules, or arterioles. (
  • Hypersensitivity vasculitis may look like systemic, necrotizing vasculitis , which can affect blood vessels throughout the body and not just in the skin. (
  • Chessman D, Kostenko L, Lethborg T, Purcell AW, Williamson NA, Chen Z. Human leukocyte antigen class I-restricted activation of CD8+ T cells provides the immunogenetic basis of a systemic drug hypersensitivity. (
  • Seminal fluid hypersensitivity usually is characterized by postcoital vulvovaginal itching, swelling, redness, with or without systemic signs and symptoms. (
  • Lung changes due to chronic hypersensitivity pneumonitis may be seen on a chest x-ray . (
  • What is chronic hypersensitivity pneumonitis? (
  • Chronic (long-term) hypersensitivity pneumonitis causes lung scarring (fibrosis). (
  • What are the symptoms of chronic hypersensitivity pneumonitis? (
  • Differentiating chronic hypersensitivity pneumonitis from idiopathic pulmonary fibrosis is particularly important because the prognosis for the former improves when the offending antigen is identified and eliminated. (
  • Subacute and chronic hypersensitivity pneumonitis has been misdiagnosed as asthma , a condition that can also cause cough, dyspnea, and exercise intolerance. (
  • Chronic hypersensitivity pneumonitis may be misdiagnosed as anorexia nervosa . (
  • Hypersensitivity vasculitis may be acute and self-limited, recurrent, or chronic. (
  • The final report could call UIP pattern (with the corresponding level of confidence, with or without ancillary findings suggesting chronic hypersensitivity pneumonitis or collagen vascular disease), other patterns (low or high confidence), specific diagnosis (eg, Langerhans cell histiocytosis, lymphangioleiomyomatosis, malignant epithelial tumors, lymphoproliferative diseases, infections), and no pattern or unclassified fibrosis/inflammation. (
  • The differential diagnosis of cryptogenic organizing pneumonia (BOOP) includes diseases like community-acquired pneumonia, idiopathic interstitial pneumonias, hypersensitivity pneumonitis , chronic eosinophilic pneumonia, and sarcoidosis [1,4]. (
  • Metal hypersensitivity is a cell-mediated immune response that can lead to various diseases, including the granulomatous lung disease called Chronic Beryllium Disease. (
  • Aspergillus fumigatus IgG: the test may be used as an adjunct to the diagnosis of hypersensitivity pneumonitis and chronic pulmonary aspergillosis due to Aspergillus fumigatus . (
  • We thank Dr. Lacasse and the HP Study Group for their correspondence regarding 'A diagnostic model for chronic hypersensitivity pneumonitis', and appreciate their thoughtful consideration of our work. (
  • Visceral hypersensitivity entangles both the internal organs and the central nervous system in a nasty web of chronic pain. (
  • Hypersensitivity, commonly known as allergy could be defined as an exaggerated response of immune system towards certain allergens present in environment. (
  • Also searched for Egg Hypersensitivities , Egg allergy , Allergy to eggs and more. (
  • Disease and disorder research has been conducted in relation to the Hypersensitivity Pathway and Delayed Hypersensitivity, Allergy, Immediate Hypersensitivity, Inflammation, Pain. (
  • The term "allergy" was used in the questionnaire, as it is the most recognized term among the general population, even though "drug hypersensitivity" is probably be more accurate. (
  • Delayed dermal hypersensitivity testing (patch test) can generally pinpoint this kind of allergy. (
  • Pharmacovigilance of drug allergy and hypersensitivity using the ENDA-DAHD database and the GA2LEN platform. (
  • The Gell and Coombs classification of hypersensitivity is the most widely used, and distinguishes four types of immune response which result in bystander tissue damage. (
  • International Classification of Diseases (ICD) rubrics and codes for Hypersensitivity Pneumonitis (as defined for NORMS). (
  • Metzger F, Haccuria A, Reboux G, Nolard N, Dalphin JC, De Vuyst P. Hypersensitivity pneumonitis due to molds in a saxophone player. (
  • J67.8 - Hypersensitivity pneumonitis due to other organic dusts is a sample topic from the ICD-10-CM . (
  • ICD-10 , (
  • [2] [5] i.e., dentin hypersensitivity is not a true form of allodynia or hyperalgesia . (
  • Other types of stimuli may also trigger pain in dentin hypersensitivity, including: Thermal - hot and cold drinks and foods, cold air, coolant water jet from a dental instrument. (
  • Introduction: Dentin hypersensitivity (DH) could be defined as a brief and sharp pain in response to thermical, chemical, tactile and osmotic stimuli, which cannot be attributed to any den. (
  • UNO Gel provides rapid and long-lasting relief from dentin hypersensitivity, a common dental complaint that can significantly impair eating, drinking or speaking. (
  • [11] If a negative result for the pain provocation test occurs, no treatment for dentinal hypersensitivity is indicated and another diagnosis should be sought, such as other causes of orofacial pain . (
  • To assess the efficacy of in-office employed lasers versus other therapeutic approaches, placebo laser, placebo agents or no treatment for relieving pain of dentinal hypersensitivity. (
  • The protocols for the study will be developed as per the guidelines for the design and conduct of clinical trials on dentinal hypersensitivity and in accordance with the Declaration of Helsinki and Guidelines for Good Clinical Practice. (
  • How can esophageal hypersensitivity cause chest pain? (
  • Esophageal hypersensitivity is when the esophagus becomes very painful at the smallest change in pressure or exposure to acid. (
  • I did some reading and found something called esophageal hypersensitivity. (
  • Hypersensitivity vasculitis most often goes away over time. (
  • Call your provider if you have symptoms of hypersensitivity vasculitis. (
  • Hypersensitivity syndromes and vasculitis. (
  • Hypersensitivity vasculitis, which is usually represented histopathologically as leukocytoclastic vasculitis (LCV), is a term commonly used to denote a small-vessel vasculitis. (
  • The internal organs most commonly affected in hypersensitivity vasculitis are the joints, gastrointestinal tract, and kidneys. (
  • Overall, hypersensitivity vasculitis has a favorable prognosis, particularly when no internal involvement is present. (
  • Hypersensitivity vasculitis is thought to be mediated by immune complex deposition. (
  • Overall, however, the exact mechanisms causing hypersensitivity vasculitis remain to be elucidated. (
  • Antibiotics are the most common drugs to cause hypersensitivity vasculitis, particularly beta-lactams. (
  • Effective management of malignancy can lead to resolution of the hypersensitivity vasculitis. (
  • Candida albicans IgG: the test may be used as an adjunct to the diagnosis of hypersensitivity pneumonitis. (
  • Individuals with allergic, or atopic, hypersensitivity form special weak types of antibodies, that cause local tissue damage and such symptoms as hives , hay fever , and asthma . (
  • Symptoms of acute hypersensitivity pneumonitis often occur 4 to 6 hours after you have left the area where the offending substance is found. (
  • What are the symptoms of acute hypersensitivity pneumonitis? (
  • Hypersensitivity pneumonitis (HP) develops after inhalation of many different environmental antigens, causing variable clinical symptoms that often make diagnosis uncertain. (
  • The Percentage of Participants With Adjudicated Hypersensitivity Signs/Symptoms, for Each Sugammadex Dose Group and Placebo. (
  • Hypersensitivity signs/symptoms were systematically collected for each subject by the investigator. (
  • Suspected cases of hypersensitivity signs/symptoms were sent to the independent Adjudication Committee (comprised of anesthesiologists & allergists/immunologists) for blinded review and determination of adjudicated hypersensitivity &/or anaphylaxis based on expert evaluation of all clinical data from the healthy subject. (
  • The Adjudication Committee evaluated each case to determine whether the subject's hypersensitivity sign/symptoms fulfilled the definition of anaphylaxis according to the criteria defined by the Symposium on the Definition and Management of Anaphylaxis as described by Sampson et al. (
  • An Austrian telephone study of a cross section of 526 people by Schroettner & Leitgeb (2008), showed that an increasing number of people suffer from non-specific health symptoms such as headaches, sleep disturbances, difficulties in concentrating etc and attribute their ill health to electromagnetic hypersensitivity (EHS) and electromagnetic pollution. (
  • Please if anyone has same symptoms (sour/acid mouth, burning throat & chest, post nasal drip, belching) and was diagnosed with hypersensitivity and was prescribed with amitriptyline (or similar drugs) and managed to get through this, please please share your experience. (
  • And, that's what nearly all such studies have found: "no evidence" that the symptoms are anything but "psychological" in nature, noting that those who claim such hypersensitivity tend to exhibit more obsessive-compulsive, hostile, phobic, and paranoid traits. (
  • What is acute hypersensitivity pneumonitis? (
  • Acute hypersensitivity pneumonitis tends to occur 4-12 hours after exposure (usually heavy exposure) to the particles. (
  • Acute hypersensitivity pneumonitis (HP) closely resembles viral or bacterial infections of the lower respiratory tract. (
  • We report a case of hypersensitivity myocarditis secondary to clozapine administration that was diagnosed in vivo for the first time through endomyocardial biopsy and was successfully treated with corticosteroids. (
  • Its use, limited by the well-known agranulocytosis risk, has also been associated with severe cardiovascular side effects and sudden death.1-3 Both dilated cardiomyopathy and myocarditis, as result of direct toxicity and drug hypersensitivity, respectively, have been described at autopsy.2,3 We report a case of hypersensitivity myocarditis secondary to clozapine administration diagnosed for the first time in vivo by endomyocardial biopsy and successfully treated with corticosteroids. (
  • An unusual case was published involving a case of hypersensitivity to Canadian goose dropping s. (
  • [7] The most common trigger is cold, [1] with 75% of people with hypersensitivity reporting pain upon application of a cold stimulus. (
  • Sometimes, treatments used for asthma can help people with hypersensitivity pneumonitis. (
  • The prevalence of self-reported drug hypersensitivity was 12,11% (123/1015). (
  • The aim of this study was to estimate the prevalence of self-reported drug hypersensitivity and its characteristics in a university population from São Paulo, Brazil. (
  • In type 2 hypersensitivity, the antibodies produced by the immune response bind to antigens on the patient's own cell surfaces. (
  • Type 3 hypersensitivity occurs when antigens and antibodies are present in roughly equal amounts, causing extensive cross-linking. (
  • The Hypersensitivity Pathway complements our catalog of research reagents including antibodies and ELISA kits against OVALBUMIN, BCG, ALB, CD2, CD4. (
  • We have 3105 products for the study of the Hypersensitivity Pathway that can be applied to Chromatin Immunoprecipitation, Flow Cytometry, Western Blot, Immunocytochemistry/Immunofluorescence, Immunohistochemistry from our catalog of antibodies and ELISA kits. (
  • Hypersensitivity pneumonia s are a spectrum of disorders that arise from an allergic response to the inhalation of a variety of organic dusts. (
  • Hypersensitivity pneumonitis usually occurs in people who work in places where there are high levels of organic dusts, fungus, or molds. (
  • It can also cause a condition known as hypersensitivity pneumonitis or HP, a kind of lung inflammation that occurs in people who develop immune system sensitization to inhaled organic dusts. (
  • Indoor Environmental Consultants (IEC) provides mold testing and consulting services to help prevent hypersensitivity pneumonitis (HP) and other health issues. (
  • The bioactive polymer used in UNO forms a rapid, protective, dentin integrated layer to prevent hypersensitivity", said Dr. Kishen. (
  • The parents of 15-year-old Jenny Fry claim that she suffered from electro-hypersensitivity (EHS), which caused her to suffer tiredness, headaches and bladder problems. (
  • It depends where you have visceral hypersensitivity, in the stomach or osophagus or in bowls. (
  • I had visceral hypersensitivity in the stomach. (
  • Some people are troubled by such a problem called visceral hypersensitivity . (
  • In the case of visceral hypersensitivity, everything from digestion to urination can become painful. (
  • 1 All of these conditions are really just a form of visceral hypersensitivity. (
  • But the diagnosis of visceral hypersensitivity can be difficult because gut pain can be so vague, so hard to pinpoint and so widespread. (
  • The biggest hallmark of visceral hypersensitivity to watch out for is pain provoked with normally non-painful stimuli. (
  • Once the diagnosis of visceral hypersensitivity is made, the treatment can be tricky. (
  • Alternatives to medications are also worth mentioning for the treatment of visceral hypersensitivity, especially those that provoke a relaxation response like meditation, hypnosis or visualization. (
  • What used to be called "Electromagnetic Hypersensitivity" in the medical literature is now called "Idiopathic Environmental Intolerance Attributed to Electromagnetic Fields," an acronym that sounds like something straight out of Old MacDonald's Farm. (
  • Other psychiatric problems that often coexist with tics and tic disorders include learning disorders, impulse control disorders, school phobia, sensory hypersensitivity , and rage attacks. (
  • Hoxb8-dependent reinstatement of NECAB2 expression in Necab2-/- mice then demonstrated that spinal and DRG NECAB2 alone could control inflammation-induced sensory hypersensitivity. (
  • New research shows that patients with fibromyalgia have hypersensitivity to non-painful events based on images of the patients' brains, which show reduced activation in primary sensory regions and increased activation in sensory integration areas. (
  • however, the precise mechanisms accounting for the sensory hypersensitivity are not understood. (
  • These findings also suggest that selective TRPV1 antagonists are potential therapeutic drugs for treating retinoid-induced sensory hypersensitivity. (
  • Epidemiology and causes of hypersensitivity pneumonitis (extrinsic allergic alveolitis) 2005. (
  • Hypersensitivity pneumonitis is inflammation of the lungs due to breathing in a foreign substance, usually certain types of dust, fungus, or molds. (
  • DENVER - The American College of Chest Physicians has published new guidelines for the diagnosis and evaluation of hypersensitivity pneumonitis (HP), an interstitial lung disease characterized by scarring and/or inflammation of the interstitium - the area surrounding the lung's air sacs, blood vessels and airways. (
  • We will present the characteristics and pathogenetic mechanisms of this hypersensitivity, as well as the basic management options available to date. (
  • Granulomatous lung diseases (eg, tuberculosis , histoplasmosis , coccidiomycosis, sarcoidosis ) can also produce findings similar to those of subacute hypersensitivity pneumonitis. (
  • Undoubtedly, subacute hypersensitivity pneumonitis (HP) can resolve completely with immunosuppression. (
  • What is the role of immune hypersensitivity in the pathophysiology of acute urticaria (hives)? (
  • Hypersensitivity pneumonitis (HP) is a respiratory disease caused by an exaggerated immune response to inhaled antigens, usually organic in nature. (