AnatomyDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesNamed Groups
Congenital HyperinsulinismHyperinsulinismSulfonylurea ReceptorsReceptors, DrugPotassium Channels, Inwardly RectifyingDiazoxideHypoglycemiaDiagnostic Techniques, EndocrineHyperammonemiaGlutamate DehydrogenaseATP-Binding Cassette TransportersPancreatectomyInsulinInsulinomaKATP ChannelsInsulin AntibodiesSulfonylurea CompoundsBeckwith-Wiedemann Syndrome3-Hydroxyacyl CoA DehydrogenasesPotassium ChannelsInfant, NewbornCongenital Disorders of GlycosylationCyclin-Dependent Kinase Inhibitor p57MutationChromosomes, Human, Pair 11Islets of LangerhansTolbutamideInsulin-Secreting CellsHyperandrogenismBlood GlucoseMutation, MissenseChlorthalidoneOctreotideProinsulinPancreasHamartomaC-PeptideHeterozygoteMosaicismPancreatic NeoplasmsHypopituitarismPedigreeAmmoniaSeizuresGenes, DominantSyndromeAdenosine TriphosphateGlucoseHomozygoteGlucose Tolerance TestPoint Mutation
Congenital Hyperinsulinism
A familial, nontransient HYPOGLYCEMIA with defects in negative feedback of GLUCOSE-regulated INSULIN release. Clinical phenotypes include HYPOGLYCEMIA; HYPERINSULINEMIA; SEIZURES; COMA; and often large BIRTH WEIGHT. Several sub-types exist with the most common, type 1, associated with mutations on an ATP-BINDING CASSETTE TRANSPORTERS (subfamily C, member 8).
Hyperinsulinism
A syndrome with excessively high INSULIN levels in the BLOOD. It may cause HYPOGLYCEMIA. Etiology of hyperinsulinism varies, including hypersecretion of a beta cell tumor (INSULINOMA); autoantibodies against insulin (INSULIN ANTIBODIES); defective insulin receptor (INSULIN RESISTANCE); or overuse of exogenous insulin or HYPOGLYCEMIC AGENTS.
Sulfonylurea Receptors
ATP-BINDING CASSETTE PROTEINS that are highly conserved and widely expressed in nature. They form an integral part of the ATP-sensitive potassium channel complex which has two intracellular nucleotide folds that bind to sulfonylureas and their analogs.
Receptors, Drug
Proteins that bind specific drugs with high affinity and trigger intracellular changes influencing the behavior of cells. Drug receptors are generally thought to be receptors for some endogenous substance not otherwise specified.
Potassium Channels, Inwardly Rectifying
Potassium channels where the flow of K+ ions into the cell is greater than the outward flow.
Diazoxide
A benzothiadiazine derivative that is a peripheral vasodilator used for hypertensive emergencies. It lacks diuretic effect, apparently because it lacks a sulfonamide group.
Hypoglycemia
A syndrome of abnormally low BLOOD GLUCOSE level. Clinical hypoglycemia has diverse etiologies. Severe hypoglycemia eventually lead to glucose deprivation of the CENTRAL NERVOUS SYSTEM resulting in HUNGER; SWEATING; PARESTHESIA; impaired mental function; SEIZURES; COMA; and even DEATH.
Diagnostic Techniques, Endocrine
Methods and procedures for the diagnosis of diseases or dysfunction of the endocrine glands or demonstration of their physiological processes.
Hyperammonemia
Elevated level of AMMONIA in the blood. It is a sign of defective CATABOLISM of AMINO ACIDS or ammonia to UREA.
Glutamate Dehydrogenase
An enzyme that catalyzes the conversion of L-glutamate and water to 2-oxoglutarate and NH3 in the presence of NAD+. (From Enzyme Nomenclature, 1992) EC 1.4.1.2.
ATP-Binding Cassette Transporters
A family of MEMBRANE TRANSPORT PROTEINS that require ATP hydrolysis for the transport of substrates across membranes. The protein family derives its name from the ATP-binding domain found on the protein.
Pancreatectomy
Surgical removal of the pancreas. (Dorland, 28th ed)
Insulin
A 51-amino acid pancreatic hormone that plays a major role in the regulation of glucose metabolism, directly by suppressing endogenous glucose production (GLYCOGENOLYSIS; GLUCONEOGENESIS) and indirectly by suppressing GLUCAGON secretion and LIPOLYSIS. Native insulin is a globular protein comprised of a zinc-coordinated hexamer. Each insulin monomer containing two chains, A (21 residues) and B (30 residues), linked by two disulfide bonds. Insulin is used as a drug to control insulin-dependent diabetes mellitus (DIABETES MELLITUS, TYPE 1).
Insulinoma
A benign tumor of the PANCREATIC BETA CELLS. Insulinoma secretes excess INSULIN resulting in HYPOGLYCEMIA.
KATP Channels
Heteromultimers of Kir6 channels (the pore portion) and sulfonylurea receptor (the regulatory portion) which affect function of the HEART; PANCREATIC BETA CELLS; and KIDNEY COLLECTING DUCTS. KATP channel blockers include GLIBENCLAMIDE and mitiglinide whereas openers include CROMAKALIM and minoxidil sulfate.
Insulin Antibodies
Antibodies specific to INSULIN.
Sulfonylurea Compounds
Beckwith-Wiedemann Syndrome
A syndrome of multiple defects characterized primarily by umbilical hernia (HERNIA, UMBILICAL); MACROGLOSSIA; and GIGANTISM; and secondarily by visceromegaly; HYPOGLYCEMIA; and ear abnormalities.
3-Hydroxyacyl CoA Dehydrogenases
Enzymes that reversibly catalyze the oxidation of a 3-hydroxyacyl CoA to 3-ketoacyl CoA in the presence of NAD. They are key enzymes in the oxidation of fatty acids and in mitochondrial fatty acid synthesis.
Potassium Channels
Cell membrane glycoproteins that are selectively permeable to potassium ions. At least eight major groups of K channels exist and they are made up of dozens of different subunits.
Infant, Newborn
An infant during the first month after birth.
Congenital Disorders of Glycosylation
A genetically heterogeneous group of heritable disorders resulting from defects in protein N-glycosylation.
Cyclin-Dependent Kinase Inhibitor p57
A potent inhibitor of CYCLIN-DEPENDENT KINASES in G1 PHASE and S PHASE. In humans, aberrant expression of p57 is associated with various NEOPLASMS as well as with BECKWITH-WIEDEMANN SYNDROME.
Mutation
Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.
Chromosomes, Human, Pair 11
A specific pair of GROUP C CHROMOSOMES of the human chromosome classification.
Islets of Langerhans
Irregular microscopic structures consisting of cords of endocrine cells that are scattered throughout the PANCREAS among the exocrine acini. Each islet is surrounded by connective tissue fibers and penetrated by a network of capillaries. There are four major cell types. The most abundant beta cells (50-80%) secrete INSULIN. Alpha cells (5-20%) secrete GLUCAGON. PP cells (10-35%) secrete PANCREATIC POLYPEPTIDE. Delta cells (~5%) secrete SOMATOSTATIN.
Tolbutamide
A sulphonylurea hypoglycemic agent with actions and uses similar to those of CHLORPROPAMIDE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p290)
Insulin-Secreting Cells
A type of pancreatic cell representing about 50-80% of the islet cells. Beta cells secrete INSULIN.
Hyperandrogenism
A condition caused by the excessive secretion of ANDROGENS from the ADRENAL CORTEX; the OVARIES; or the TESTES. The clinical significance in males is negligible. In women, the common manifestations are HIRSUTISM and VIRILISM as seen in patients with POLYCYSTIC OVARY SYNDROME and ADRENOCORTICAL HYPERFUNCTION.
Blood Glucose
Glucose in blood.
Mutation, Missense
A mutation in which a codon is mutated to one directing the incorporation of a different amino acid. This substitution may result in an inactive or unstable product. (From A Dictionary of Genetics, King & Stansfield, 5th ed)
Chlorthalidone
A benzenesulfonamide-phthalimidine that tautomerizes to a BENZOPHENONES form. It is considered a thiazide-like diuretic.
Octreotide
A potent, long-acting synthetic SOMATOSTATIN octapeptide analog that inhibits secretion of GROWTH HORMONE and is used to treat hormone-secreting tumors; DIABETES MELLITUS; HYPOTENSION, ORTHOSTATIC; HYPERINSULINISM; hypergastrinemia; and small bowel fistula.
Proinsulin
A pancreatic polypeptide of about 110 amino acids, depending on the species, that is the precursor of insulin. Proinsulin, produced by the PANCREATIC BETA CELLS, is comprised sequentially of the N-terminal B-chain, the proteolytically removable connecting C-peptide, and the C-terminal A-chain. It also contains three disulfide bonds, two between A-chain and B-chain. After cleavage at two locations, insulin and C-peptide are the secreted products. Intact proinsulin with low bioactivity also is secreted in small amounts.
Pancreas
A nodular organ in the ABDOMEN that contains a mixture of ENDOCRINE GLANDS and EXOCRINE GLANDS. The small endocrine portion consists of the ISLETS OF LANGERHANS secreting a number of hormones into the blood stream. The large exocrine portion (EXOCRINE PANCREAS) is a compound acinar gland that secretes several digestive enzymes into the pancreatic ductal system that empties into the DUODENUM.
Hamartoma
A focal malformation resembling a neoplasm, composed of an overgrowth of mature cells and tissues that normally occur in the affected area.
C-Peptide
The middle segment of proinsulin that is between the N-terminal B-chain and the C-terminal A-chain. It is a pancreatic peptide of about 31 residues, depending on the species. Upon proteolytic cleavage of proinsulin, equimolar INSULIN and C-peptide are released. C-peptide immunoassay has been used to assess pancreatic beta cell function in diabetic patients with circulating insulin antibodies or exogenous insulin. Half-life of C-peptide is 30 min, almost 8 times that of insulin.
Heterozygote
An individual having different alleles at one or more loci regarding a specific character.
Mosaicism
The occurrence in an individual of two or more cell populations of different chromosomal constitutions, derived from a single ZYGOTE, as opposed to CHIMERISM in which the different cell populations are derived from more than one zygote.
Pancreatic Neoplasms
Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).
Hypopituitarism
Diminution or cessation of secretion of one or more hormones from the anterior pituitary gland (including LH; FOLLICLE STIMULATING HORMONE; SOMATOTROPIN; and CORTICOTROPIN). This may result from surgical or radiation ablation, non-secretory PITUITARY NEOPLASMS, metastatic tumors, infarction, PITUITARY APOPLEXY, infiltrative or granulomatous processes, and other conditions.
Pedigree
The record of descent or ancestry, particularly of a particular condition or trait, indicating individual family members, their relationships, and their status with respect to the trait or condition.
Ammonia
A colorless alkaline gas. It is formed in the body during decomposition of organic materials during a large number of metabolically important reactions. Note that the aqueous form of ammonia is referred to as AMMONIUM HYDROXIDE.
Seizures
Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or "seizure disorder."
Genes, Dominant
Genes that influence the PHENOTYPE both in the homozygous and the heterozygous state.
Syndrome
A characteristic symptom complex.
Adenosine Triphosphate
An adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.
Glucose
A primary source of energy for living organisms. It is naturally occurring and is found in fruits and other parts of plants in its free state. It is used therapeutically in fluid and nutrient replacement.
Homozygote
An individual in which both alleles at a given locus are identical.
Glucose Tolerance Test
A test to determine the ability of an individual to maintain HOMEOSTASIS of BLOOD GLUCOSE. It includes measuring blood glucose levels in a fasting state, and at prescribed intervals before and after oral glucose intake (75 or 100 g) or intravenous infusion (0.5 g/kg).
Point Mutation
A mutation caused by the substitution of one nucleotide for another. This results in the DNA molecule having a change in a single base pair.

Effect of hyperglycemia-hyperinsulinemia on whole body and regional fatty acid metabolism. (1/1504)

The effects of combined hyperglycemia-hyperinsulinemia on whole body, splanchnic, and leg fatty acid metabolism were determined in five volunteers. Catheters were placed in a femoral artery and vein and a hepatic vein. U-13C-labeled fatty acids were infused, once in the basal state and, on a different occasion, during infusion of dextrose (clamp; arterial glucose 8.8 +/- 0.5 mmol/l). Lipids and heparin were infused together with the dextrose to maintain plasma fatty acid concentrations at basal levels. Fatty acid availability in plasma and fatty acid uptake across the splanchnic region and the leg were similar during the basal and clamp experiments. Dextrose infusion decreased fatty acid oxidation by 51.8% (whole body), 47.4% (splanchnic), and 64.3% (leg). Similarly, the percent fatty acid uptake oxidized decreased at the whole body level (53 to 29%), across the splanchnic region (30 to 13%), and in the leg (48 to 22%) during the clamp. We conclude that, in healthy men, combined hyperglycemia-hyperinsulinemia inhibits fatty acid oxidation to a similar extent at the whole body level, across the leg, and across the splanchnic region, even when fatty acid availability is constant.  (+info)

Relative contribution of insulin and its precursors to fibrinogen and PAI-1 in a large population with different states of glucose tolerance. The Insulin Resistance Atherosclerosis Study (IRAS). (2/1504)

Hyperinsulinemia is associated with the development of coronary heart disease. However, the underlying mechanisms are still poorly understood. Hypercoagulability and impaired fibrinolysis are possible candidates linking hyperinsulinism with atherosclerotic disease, and it has been suggested that proinsulin rather than insulin is the crucial pathophysiological agent. The aim of this study was to investigate the relationship of insulin and its precursors to markers of coagulation and fibrinolysis in a large triethnic population. A strong and independent relationship between plasminogen activator inhibitor-1 (PAI-1) antigen and insulin and its precursors (proinsulin, 32-33 split proinsulin) was found consistently across varying states of glucose tolerance (PAI-1 versus fasting insulin [proinsulin], r=0.38 [r=0.34] in normal glucose tolerance; r=0.42 [r=0.43] in impaired glucose tolerance; and r=0.38 [r=0.26] in type 2 diabetes; all P<0.001). The relationship remained highly significant even after accounting for insulin sensitivity as measured by a frequently sampled intravenous glucose tolerance test. In a stepwise multiple regression model after adjusting for age, sex, ethnicity, and clinic, both insulin and its precursors were significantly associated with PAI-1 levels. The relationship between fibrinogen and insulin and its precursors was significant in the overall population (r=0.20 for insulin and proinsulin; each P<0.001) but showed a more inconsistent pattern in subgroup analysis and after adjustments for demographic and metabolic variables. Stepwise multiple regression analysis showed that proinsulin (split products) but not fasting insulin significantly contributed to fibrinogen levels after adjustment for age, sex, clinic, and ethnicity. Decreased insulin sensitivity was independently associated with higher PAI-1 and fibrinogen levels. In summary, we were able to demonstrate an independent relationship of 2 crucial factors of hemostasis, fibrinogen and PAI-1, to insulin and its precursors. These findings may have important clinical implications in the risk assessment and prevention of macrovascular disease, not only in patients with overt diabetes but also in nondiabetic subjects who are hyperinsulinemic.  (+info)

The contributions of oestrogen and growth factors to increased adrenal androgen secretion in polycystic ovary syndrome. (3/1504)

Adrenal hyperandrogenism is prevalent in many women with polycystic ovary syndrome (PCOS), although the expression of this enhanced secretion may be heterogeneous. Since no single factor acts in isolation, this study was performed to assess the influence of oestradiol (total and unbound), insulin, insulin-like growth factor (IGF)-I, IGF-II and the binding proteins IGFBP-I, and IGFBP-3, on basal and adrenocorticotrophic hormone (ACTH) stimulated adrenal androgen secretion in 25 women with PCOS and 10 matched ovulatory controls. Women with PCOS exhibited elevations of all androgens as well as unbound oestradiol, insulin and non-IGFBP-1 bound IGF-I. Positive correlations were noted between oestrogen and basal and ACTH stimulated delta 5 adrenal androgens. Serum IGF-I was only correlated with basal dehydroepiandrosterone sulphate (DHEA-S), while insulin exhibited a strong correlation with the delta 4 pathway and androstenedione formation in particular. This correlation was also confirmed by dividing the PCOS group into those women with and without hyperinsulinaemia. The activity of 17,20 lyase favouring androstenedione was increased in the hyperinsulinaemic women. By multivariate analyses, body mass index did not influence these findings. Although there are inherent difficulties in making major conclusions based on correlative analyses, it is suggested that oestrogen may have a greater influence on enhancing delta 5 adrenal androgen secretion, and insulin a greater effect on the delta 4 pathway. In turn, the relative importance of these influences may contribute to the heterogeneous nature of adrenal hyperandrogenism in PCOS.  (+info)

Pancreatic exocrine and endocrine function after pancreatectomy for persistent hyperinsulinaemic hypoglycaemia of infancy. (4/1504)

AIM: To evaluate long term detailed pancreatic endocrine and exocrine function in children with persistent hyperinsulinaemic hypoglycaemia of infancy (PHHI) after 85-95% pancreatectomy. METHODS: Six children with PHHI between 0.9 and 12.7 years after pancreatic resection underwent clinical and investigative follow up at 1.0 to 14.9 years of age. One child with PHHI who had not had pancreatectomy was also assessed. Standard endocrine assessment, pancreatic magnetic resonance imaging (MRI), and detailed direct and indirect tests of exocrine pancreatic function were performed. RESULTS: Pancreozymin-secretin stimulation test results were normal in only one child, borderline in two, and deficient in four, one of whom requires daily pancreatic enzyme supplements. Pancreolauryl tests performed in three children were borderline in two and abnormal in the other. Only one child had low faecal chymotrypsin values. One child developed insulin dependent diabetes at 9 years and two children at 1.0 and 13.3 years require diazoxide to maintain normoglycaemia. MRI showed no major regrowth of the pancreatic remnant after resection (n = 5). CONCLUSIONS: Clinical evidence of endocrine or exocrine dysfunction has developed in only two patients to date, but detailed pancreatic function testing suggests subclinical deficiency in all but one of our patients with PHHI. Although 95% pancreatectomy results in postoperative control of blood glucose, subclinical pancreatic insufficiency is present on long term follow up and development of diabetes mellitus and exocrine failure remain ongoing risks.  (+info)

Long-term follow up of persistent hyperinsulinaemic hypoglycaemia of infancy. (5/1504)

Twenty six children with hypoglycaemia were diagnosed and followed between 1975 and 1995. Diagnosis was confirmed by a high insulin:glucose ratio, and low free fatty acid and 3-hydroxybutyrate on fasting. All patients were treated with diazoxide at a maximum dose of 20 mg/kg/day. Requirement of a higher dose was considered as a failure of medical treatment and an indication for surgery. Sixteen children Responded to diazoxide; 10 failed to respond and underwent pancreatic resection. Six of the latter group started with symptoms in the neonatal period. Eleven of the 26 children have neurological sequelae. Head growth and neurological outcome correlated well. Additionally, non-specific electroencephalogram abnormalities (slow waves) appear to be indicative of subclinical hypoglycaemia during follow up.  (+info)

Hyperinsulinism: molecular aetiology of focal disease. (6/1504)

Persistent hypoglycaemia in infancy is most commonly caused by hyperinsulinism. A case is reported of the somatic loss of the maternal 11p in an insulin secreting focal adenoma in association with a germline SUR-1 mutation on the paternal allele in a baby boy with hyperinsulinism diagnosed at 49 days old. A reduction to homozygosity of an SUR-1 mutation is proposed as a critical part of the cause of focal hyperinsulinism.  (+info)

The structure and function of the ATP-sensitive K+ channel in insulin-secreting pancreatic beta-cells. (7/1504)

ATP-sensitive K+ channels (KATP channels) play important roles in many cellular functions by coupling cell metabolism to electrical activity. The KATP channels in pancreatic beta-cells are thought to be critical in the regulation of glucose-induced and sulfonylurea-induced insulin secretion. Until recently, however, the molecular structure of the KATP channel was not known. Cloning members of the novel inwardly rectifying K+ channel subfamily Kir6.0 (Kir6.1 and Kir6.2) and the sulfonylurea receptors (SUR1 and SUR2) has clarified the molecular structure of KATP channels. The pancreatic beta-cell KATP channel comprises two subunits: a Kir6.2 subunit and an SUR1 subunit. Molecular biological and molecular genetic studies have provided insights into the physiological and pathophysiological roles of the pancreatic beta-cell KATP channel in insulin secretion.  (+info)

Surgery-induced insulin resistance in human patients: relation to glucose transport and utilization. (8/1504)

To investigate the underlying molecular mechanisms for surgery-induced insulin resistance in skeletal muscle, six otherwise healthy patients undergoing total hip replacement were studied before, during, and after surgery. Patients were studied under basal conditions and during physiological hyperinsulinemia (60 microU/ml). Biopsies of vastus lateralis muscle were used to measure GLUT-4 translocation, glucose transport, and glycogen synthase activities. Surgery reduced insulin-stimulated glucose disposal (P < 0.05) without altering the insulin-stimulated increase in glucose oxidation or suppression of endogenous glucose production. Preoperatively, insulin infusion increased plasma membrane GLUT-4 in all six subjects (P < 0.05), whereas insulin-stimulated GLUT-4 translocation only occurred in three patients postoperatively (not significant). Moreover, nonoxidative glucose disposal rates and basal levels of glycogen synthase activities in muscle were reduced postoperatively (P < 0.05). These findings demonstrate that peripheral insulin resistance develops immediately postoperatively and that this condition might be associated with perturbations in insulin-stimulated GLUT-4 translocation as well as nonoxidative glucose disposal, presumably at the level of glycogen synthesis.  (+info)

Hyperinsulinaemic dictionary definition | hyperinsulinaemic definedHyperinsulinaemic dictionary definition | hyperinsulinaemic defined
hyperinsulinaemic definition: Adjective (comparative more hyperinsulinaemic, superlative most hyperinsulinaemic) 1. (pathology) Of, pertaining to, or having hyperinsulinaemia ...
http://www.yourdictionary.com/hyperinsulinaemic
Microsoft word - mdg5214 keyword search statement atmMicrosoft word - mdg5214 keyword search statement atm
OR resistance/height2[All Fields] OR resistance/high[All Fields] OR resistance/homeostasis[All Fields] OR resistance/hyperglycemia[All Fields] OR resistance/hyperinsulinaemia[All Fields] OR resistance/hyperinsulinemia[All Fields] OR resistance/hyperinsulinemia/hyperglycemia[All Fields] OR resistance/hyperinsulinemic[All Fields] OR resistance/hyperinsulinism[All Fields] OR resistance/hyperlipidaemia[All Fields] OR resistance/hypersensitivity[All Fields] OR resistance/hypersusceptibility[All Fields] OR resistance/hypertension[All Fields] OR resistance/hypertriglyceridemia[All Fields] OR resistance/immunity[All Fields] OR resistance/impact[All Fields] OR resistance/impaired[All Fields] OR resistance/impedance[All Fields] OR resistance/inflammation[All Fields] OR resistance/inhibition[All Fields] OR resistance/innate[All Fields] OR resistance/insensitivity[All Fields] OR resistance/inspiratory[All Fields] OR resistance/insulinemia[All Fields] OR resistance/intermediate[All Fields] OR ...
http://pdfmedfinder.com/l/lib.nus.edu.sg1.html
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At vero eos et accusamus et iusto odios un dignissimos ducimus qui blan ditiis prasixer esentium voluptatum un deleniti atqueste sites excep turiitate non providentsimils. Nemo enim ipsam voluptatem quia voluptas sit aspernatur aut odit aut fugit, consequunturser magni dolores eos qui ratione voluptatem sequi nesciunt. Lorem ipsum dolor sit amet isse potenti. Vesquam ante aliquet lacusemper elit. Cras neque nulla, convallis non commodo et, euismod nonsese. Eos et accusamus et iusto odios un dignissimos ducimus qui blan ditiis prasixer esentium voluptatum un deleniti atqueste sites excep turiitate non providentsimils. Lorem ipsum dolor sit amet isse potenti. Vesquam ante aliquet lacusemper elit. Cras neque nulla, convallis non commodo et, euismod nonsese. Eos et accusamus et iusto odios un dignissimos ducimus qui blan ditiis prasixer esentium voluptatum un deleniti atqueste sites excep turiitate non ipsum dolor sit amet isse potenti. Vesquam ante aliquet lacusemper elit providentsimils.. ...
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Nursing - WriteWorkNursing - WriteWork
Commonly Used AbbreviationsAbbreviation: Terms: a (with a line on top)beforeabdabdomena.c.before meals (ante cibum)ADLactivities of daily livingad libas desired (ad libitum)admadmitted or admissionAMmorning (ante ...
http://www.writework.com/essay/nursing-6
Fisiculturista choca seguidores ao mostrar antes e depois | VEJA SÃO PAULOFisiculturista choca seguidores ao mostrar antes e depois | VEJA SÃO PAULO
Eu faço esses posts sobre inchaço de vez em quando, mas os meus seguidores ainda ficam surpresos ao ver como minha barriga fica inchada
https://vejasp.abril.com.br/blog/pop/antes-depois-instagram-inchaco/
Persistent Hyperinsulinemic Hypoglycemia | SpringerLinkPersistent Hyperinsulinemic Hypoglycemia | SpringerLink
Hyperinsulinism can occur throughout childhood but is most common in infancy. Persistent hyperinsulinemic hypoglycemia of infancy (PHHI) is the most important cause of hypoglycemia in early infancy. The excessive secretion of insulin is responsible for profound hypoglycemia and requires aggressive treatment to prevent severe and irreversible brain damage. Onset can be in the neonatal period or later, with the severity of hypoglycemia decreasing with age. PHHI is a heterogeneous disorder with two histopathological lesions, diffuse (DiPHHI) and focal (FoPHHI), which are clinically indistinguishable. FoPHHI is sporadic and characterized by somatic islet-cell hyperplasia. DiPHHI corresponds to a functional abnormality of insulin secretion in the whole pancreas and is most often recessive although rare dominant forms can occur, usually outside the newborn period. Differentiation between focal and diffuse lesions is important because the therapeutic approach and genetic counselling differ radically. ...
https://link.springer.com/chapter/10.1007%2F978-3-540-28785-8_10
2013 Family Conference in Segrate, Italy | Congenital Hyperinsulinism International2013 Family Conference in Segrate, Italy | Congenital Hyperinsulinism International
Congenital Hyperinsulinism International (CHI) held the Fifth Congenital Hyperinsulinism Family Conference at the NH Milano 2 Hotel in Segrate, Italy just outside of Milan on September 17 and 18, 2013. It was an intensive two days of presentations on many aspects of congenital hyperinsulinism, from the experience of living with the condition, to the latest research on potential new treatment options. The meeting was remarkable for showcasing a good number of new research projects, treatment options being pursued, and patient advocates working to support congenital hyperinsulinism families. The take away from this meeting is that so much is happening worldwide to improve the lives of children born with the condition. You can read a full summary of the meeting in English here or in French here.. Click here to access PDFs from the 22 presentations that were made at this conference.. ...
https://congenitalhi.org/2013-family-conference-in-segrate-italy/nggallery/slideshow
Auxological Characteristics of Persistent Hyperinsulinemic Hypoglycemia at Birth | ESPE2015Auxological Characteristics of Persistent Hyperinsulinemic Hypoglycemia at Birth | ESPE2015
Background: Most infants with persistent hyperinsulinaemic hypoglycaemia (PHH) are born large for gestational age (LGA) due to excessive anabolic effect of prenatal hyperinsulinism. However, other auxological characteristics than weight in infants with PHH have not been described well.. Objective: The objective of this investigation was to characterize anthropometric parameters at birth (weight, length, and head circumference) in PHH compared with those in idiopathic LGA.. Method: Clinical data in full term birth for PHH and idiopathic LGA were retrospectively collected at two institutions. We excluded infants of diabetic mothers or those with known overgrowth syndrome. Variables analysed included birth weight SDS, length SDS, and head circumference SDS. The variables between PHH and idiopathic LGA were compared using the Mann Whitney U test.. Results: The present study included seven infants with PHH and 134 with idiopathic LGA. The birth weight SDS in PHH (median, 3.03; range, 1.46 to 3.67) ...
https://abstracts.eurospe.org/hrp/0084/hrp0084P3-1073
Hyperinsulinism of infancy: Localization of focal forms<...Hyperinsulinism of infancy: Localization of focal forms<...
TY - CHAP. T1 - Hyperinsulinism of infancy. T2 - Localization of focal forms. AU - Hardy, Olga T.. AU - Stanley, Charles A.. PY - 2006. Y1 - 2006. N2 - Congenital hyperinsulinism is the most common cause of persistent hypoglycemia in infants and children (1). Infants with severe forms of the disorder (formerly termed nesidioblastosis) present with hypoglycemia in the newborn period and are at high risk of seizures, permanent brain damage, and retardation. Infants with congenital hyperinsulinism may have either focal or diffuse abnormalities of the pancreatic β cells. In cases with diffuse disease, an underlying defect in the β-cell adenosoine triphosphate (ATP)-dependent potassium channel may be present, caused by recessive loss of function mutations of the two genes encoding the KATP channel, SUR1 or Kir6.2 (1,2). These mutations may also cause focal hyperinsulinism in which there is an area of β-cell adenomatosis due to loss of heterozygosity for the maternal 11p region and expression of a ...
https://utsouthwestern.pure.elsevier.com/en/publications/hyperinsulinism-of-infancy-localization-of-focal-forms
Congenital Hyperinsulinism | Hyperinsulinism GenesCongenital Hyperinsulinism | Hyperinsulinism Genes
Congenital hyperinsulinaemic hypoglycaemia (HH) is characterised by the inappropriate secretion of insulin despite low blood glucose levels. Hyperinsulinism may be transient or permanent. Transient hyperinsulinism can occur in babies of diabetic mothers who have been exposed to maternal hyperglycaemia before birth. Babies who have sustained perinatal asphyxia and those with intrauterine growth restriction are also at increased…
https://hyperinsulinismgenes.org/congenital-hyperinsulinism/
Acute hyperinsulinemia inhibits intramyocellular triglyceride synthesis in high-fat-fed obese rats. - Semantic ScholarAcute hyperinsulinemia inhibits intramyocellular triglyceride synthesis in high-fat-fed obese rats. - Semantic Scholar
Hyperinsulinemia is common in obesity, but whether it plays a role in intramyocellular triglyceride (imcTG) buildup is unknown. In this study, hyperinsulinemic-euglycemic clamp experiments were performed in overnight-fasted lean and high-fat-fed obese rats, awake, to determine the effect of insulin on imcTG synthesis (incorporation of [(14)C]glycerol, [(14)C]glucose, and [(3)H]oleate). Insulin infusion at 25 (low insulin) and 100 (high insulin) pmol/kg/min increased plasma insulin by 5- and 16-fold, respectively, whereas plasma and intramyocellular glycerol, FFAs, triglycerides, and glucose levels were maintained at their basal levels by co-infusion of exogenous glycerol, FFAs, and triglycerides at fixed rates and glucose at varying rates. In obese rats, insulin suppressed incorporation of glycerol into the imcTG-glycerol moiety dose dependently (P | 0.01-P | 0.001) in gastrocnemius and tibialis anterior, but only the high insulin suppressed it in soleus (P | 0.05). The low insulin suppressed glucose
https://www.semanticscholar.org/paper/Acute-hyperinsulinemia-inhibits-intramyocellular-t-Guo-Zhou/64453b6bf76dff33b124f928b908f5c542753b99
Congenital Hyperinsulinism Center Event Listing | Childrens Hospital of PhiladelphiaCongenital Hyperinsulinism Center Event Listing | Childrens Hospital of Philadelphia
This course will provide clinicians with a comprehensive review of the etiology, diagnosis, and treatment options for children with congenital hyperinsulinism.. ...
https://www.chop.edu/centers-programs/congenital-hyperinsulinism-center/event-listing
Enzyme defect leads to hyper...( Bethesda MD A recent study in the Jou...)Enzyme defect leads to hyper...( Bethesda MD A recent study in the Jou...)
Bethesda MD A recent study in the Journal of Biological Chemistry co...Congenital hyperinsulinism is a group of genetic disorders that cause ...The majority of cases of congenital hyperinsulinism appear to be due t... The glutamate dehydrogenase mutations that cause hyperinsulinism are ...In order to understand how amino acids stimulate insulin and the role ...,Enzyme,defect,leads,to,hyperinsulinism,biological,biology news articles,biology news today,latest biology news,current biology news,biology newsletters
http://news.bio-medicine.org/biology-news-3/Enzyme-defect-leads-to-hyperinsulinism-6651-1/
Congenital Hyperinsulinism Center News and Updates | Childrens Hospital of PhiladelphiaCongenital Hyperinsulinism Center News and Updates | Childrens Hospital of Philadelphia
The partnership between her doctors at The Congenital Hyperinsulinism Center at CHOP and her local medical team in California is keeping Alina healthy and allowing her to be a typical toddler. However, her beginning was anything but typical. ...
https://www.chop.edu/centers-programs/congenital-hyperinsulinism-center/news
Taken Krisim and Glyciphage earlier for high insulin level. Now have bulging tummy and weight gain. Suggestion?Taken Krisim and Glyciphage earlier for high insulin level. Now have bulging tummy and weight gain. Suggestion?
Question - Taken Krisim and Glyciphage earlier for high insulin level. Now have bulging tummy and weight gain. Suggestion? . Ask a Doctor about diagnosis, treatment and medication for Insulin resistance, Ask an OBGYN, Gynecologic Oncology
http://www.healthcaremagic.com/premiumquestions/Taken-Krisim-and-Glyciphage-earlier-for-high-insulin-level-Now-have-bulging-tummy-and-weight-gain-Suggestion/63328
CARCINOMA OF THE ISLANDS OF LANGERHANS WITH LIVER METASTASIS PRODUCING HYPERINSULINISM* | Annals of Internal Medicine |...CARCINOMA OF THE ISLANDS OF LANGERHANS WITH LIVER METASTASIS PRODUCING HYPERINSULINISM* | Annals of Internal Medicine |...
This case is being reported because of the apparent rarity of the condition and the fairly typical clinical course exhibited. A review of the literature up to the time this paper was written revealed only 131 similar cases reported in man, seven of which had either lymph node or liver metastasis or both. This patient presented the usual clinical picture associated with hyperinsulinism.2 It is to be regretted that a biological assay for insulin was not made of the metastatic nodules in the liver, as has been shown by Powers and Wilder to be conclusive proof of the origin of ...
http://annals.org/aim/article/672845/carcinoma-islands-langerhans-liver-metastasis-producing-hyperinsulinism
Hyperinsulinism? - BabyCenterHyperinsulinism? - BabyCenter
Josie will be 8 weeks old tomorrow and today she was diagnosed with hyperinsulinism. Shes had a hard time regulating her blood sugar and shes not gaining weight as quickly as the doctors would like. We have to do more testing to determine if there is a generic cause for it or if its related to the IUGR. They think it can be managed with medication but this diagnosis has bought us at least another 5 days in the NICU and when she comes home Ill have to check her blood sugar 2-3 times a day. Im just feeling so depressed and defeated at this point. Shes doing all the major things (breathing, eating, etc) but we just cant get past this blood sugar thing. Has anybody else experienced this with their IUGR baby? Even if you havent dealt with this, I could use some positivity right now. Shes so amazing and I feel like I just keep failing her
https://community.babycenter.com/post/a67575622/hyperinsulinism
Genotype and phenotype correlations in 417 children with congenital hyperinsulinismGenotype and phenotype correlations in 417 children with congenital hyperinsulinism
Genotype to phenotype correlations were most successful in children with GLUD1, GCK, and recessive KATP mutations. Correlations were complicated by the high frequency of novel missense KATP mutations that were uncharacterized, because such defects might be either recessive or dominant and, if domina …
https://pubmed.ncbi.nlm.nih.gov/23275527/?dopt=Abstract
Characterisation of new K-ATP-channel mutations associated with congenital hyperinsulinism in the Finnish population (vol 46,...Characterisation of new K-ATP-channel mutations associated with congenital hyperinsulinism in the Finnish population (vol 46,...
We use cookies to ensure that we give you the best experience on our website. If you click Continue we will assume that you are happy to receive all cookies and you will not see this message again. Click Find out more for information on how to change your cookie settings ...
https://www.dpag.ox.ac.uk/publications/114644
Altmetric - Congenital HyperinsulinismAltmetric - Congenital Hyperinsulinism
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https://www.altmetric.com/details/53773745/chapter/53773787
Bmans Blues Report: PRE-ORDER Hamilton Loomiss new CD BASICS NOW!!Bmans Blues Report: PRE-ORDER Hamilton Loomiss new CD BASICS NOW!!
Loomis is also on a mission to raise awareness about hyperinsulinism (HI), a rare disease that causes low blood sugar. His 3-year-old son was diagnosed with the life-threatening condition in 2015, and Loomis dedicates Basics opening track, Sugar Baby, to Congenital Hyperinsulinism International (www.congenitalhi.org), an organization that heads research on the disease, educates doctors and hospitals, and supports families affected by the disease. They call HI kids sugar babies, so I wanted to write a song in appreciation for all they do for families all over the world, Loomis says. ...
https://www.bmansbluesreport.com/2017/08/pre-order-hamilton-loomiss-new-cd.html
Cardiovascular risk factors in confirmed prediabetic individuals. Does the clock for coronary heart disease start ticking...Cardiovascular risk factors in confirmed prediabetic individuals. Does the clock for coronary heart disease start ticking...
Although type II diabetes is associated with both microvascular and macrovascular complications, duration of diabetes and severity of glycemia are strongly associated only with the former. Since prediabetic individuals are hyperinsulinemia, and since hyperinsulinemia may be a cardiovascular risk fac …
https://pubmed.ncbi.nlm.nih.gov/2338751/
Influence of hyperinsulinaemia and/or hyperglycaemia on | Open-iInfluence of hyperinsulinaemia and/or hyperglycaemia on | Open-i
Influence of hyperinsulinaemia and/or hyperglycaemia on proinflammatory mRNA levels. Six subjects were studied on four separate occasions: during a lower insuli
https://openi.nlm.nih.gov/detailedresult.php?img=PMC2268957_dme0025-0157-f1&req=4
Details of CORDIS-185455: Personalized diagnosis and treatment of hyperinsul...Details of CORDIS-185455: Personalized diagnosis and treatment of hyperinsul...
Background:Hyperinsulinaemic hypoglycaemia (HH) is a potentially lethal disease caused by over functioning beta cells derived from the pancreatic islets of Langerhans. Lethal HH and brain damage is a problem especially in infants with congenital HH. Current therapeutic approaches are associated with severe side effects/morbidity (diabetes, exocrine pancreas insufficiency etc.) considered acceptable in relation to the lethal outcome of HH although massively reducing quality of life and also life ...
http://agingportfolio.org/projects/project/CORDIS-185455
Hyperinsulinemic-euglycemic Clamps in Conscious, Unrestrained Mice | Protocol (Translated to Russian)Hyperinsulinemic-euglycemic Clamps in Conscious, Unrestrained Mice | Protocol (Translated to Russian)
Hyperinsulinemic-euglycemic зажим, или инсулин зажим, является золотым стандартом для оценки действия инсулина...
https://www.jove.com/video/3188/hyperinsulinemic-euglycemic-?language=Russian
Government funds expansion of Shapedown BCGovernment funds expansion of Shapedown BC
The Shapedown BC program was a lifeline for my son Brad and our family. We noticed Brads weight gain when he was in grade two, and when he was 12 years old we discovered that he had high insulin levels and high cholesterol. It became more about his health and his heart, not just his weight. Shapedown helped us make changes and set goals as a family. After the 10-week program ended, I noticed that Brad had taken what he learned and was applying it to his life - he was making better choices about meals and exercise, and had gained more confidence, too. My husband and I even lost a bit of weight! Shapedown was truly a difference maker for us, and we are thrilled to see that the program will be expanded to more kids and families across the province ...
http://www.bcchildrens.ca/about/news-stories/news/2016/government-funds-expansion-of-shapedown-bc
LITTLE STARS- Anastassias Story-Hyperinsulinism in infantsLITTLE STARS- Anastassias Story-Hyperinsulinism in infants
Little Stars Short Film Anastassias Story - Hope and Hyperinsulinism in infants dont be afraid things like this happen watch the film here to learn more
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ANTE UP! SAR with Jadelynn St Dre, MA, LMFT | AASECT:: American Association of Sexuality Educators, Counselors and TherapistsANTE UP! SAR with Jadelynn St Dre, MA, LMFT | AASECT:: American Association of Sexuality Educators, Counselors and Therapists
Title: ANTE UP! SAR with Jadelynn St Dre, MA, LMFT Date: November 13-15, 2021 Location: synchronous, virtual Presenter: Bianca I Laureano, PhD, MA, CSE and Jadelynn St Dre, MA, LMFT Sponsor (If any): Contact: Bianca I Laureano TEL: 347.948.8904 Email: [email protected] Website: https://www.eventbrite.com/e/ante-up-sar-tickets-136754952745 AASECT approved for: 13.5 (AASECT CE Credits 60 minutes = 1 CE Credit)
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Stieg Larsson Antes de Millenium - Omega Center MadridStieg Larsson Antes de Millenium - Omega Center Madrid
Serie: Antes de MilleniumAutor: Guillaume Lebeau & Frédéric RébénaEditorial: NormaIdioma: CastellanoPáginas: 64 páginas b/n 
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Ante Meridians ProfileAnte Meridians Profile
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Mutations in the sulfonylurea receptor gene in familial persistent hyperinsulinemic hypoglycemia of infancy | ScienceMutations in the sulfonylurea receptor gene in familial persistent hyperinsulinemic hypoglycemia of infancy | Science
Familial persistent hyperinsulinemic hypoglycemia of infancy (PHHI), an autosomal recessive disorder characterized by unregulated insulin secretion, is linked to chromosome 11p14-15.1. The newly cloned high-affinity sulfonylurea receptor (SUR) gene, a regulator of insulin secretion, was mapped to 11p15.1 by means of fluorescence in situ hybridization. Two separate SUR gene splice site mutations, which segregated with disease phenotype, were identified in affected individuals from nine different families. Both mutations resulted in aberrant processing of the RNA sequence and disruption of the putative second nucleotide binding domain of the SUR protein. Abnormal insulin secretion in PHHI appears to be caused by mutations in the SUR gene. ...
https://science.sciencemag.org/content/268/5209/426?ijkey=0ac88dd02fb7ca23736fda1dfaa57bda5118dd0b&keytype2=tf_ipsecsha
Alimentary hyperinsulinism | definition of alimentary hyperinsulinism by Medical dictionaryAlimentary hyperinsulinism | definition of alimentary hyperinsulinism by Medical dictionary
Looking for online definition of alimentary hyperinsulinism in the Medical Dictionary? alimentary hyperinsulinism explanation free. What is alimentary hyperinsulinism? Meaning of alimentary hyperinsulinism medical term. What does alimentary hyperinsulinism mean?
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Neonatal Insulin Secretion and Persistent Hyperinsulinemia of Infancy | American Academy of PediatricsNeonatal Insulin Secretion and Persistent Hyperinsulinemia of Infancy | American Academy of Pediatrics
An experimental approach based on genetic studies has offered new insights into the pathophysiology of persistent hyperinsulinemia of infancy. This review highlights these advances, with special emphasis on the forms of hyperinsulinemia that are associated with defects of the adenosine triphosphate (ATP)-dependent potassium (KATP) channel, a key regulator of insulin secretion in the pancreatic islets.. Persistent hyperinsulinemia of infancy has been known as nesidioblastosis, persistent hyperinsulinemic hypoglycemia of infancy, and familial hyperinsulinism since its initial recognition as a clinical entity in the 1950s. More prevalent forms of hypoglycemia that are transitory and occur in the immediate newborn period must be differentiated from persistent hyperinsulinemia of infancy, which is defined by inappropriate insulin secretion in the presence of profound hypoglycemia. The characteristic associated clinical findings (Table 1⇓ ), including inappropriate glucose-to-insulin ratios, ...
https://neoreviews.aappublications.org/content/1/11/e210.short
Endo-ERN webinar: Update on congenital hyperinsulinism | Endo-ERNEndo-ERN webinar: Update on congenital hyperinsulinism | Endo-ERN
Endo-ERN webinar: Update on congenital hyperinsulinism , Endo-ERN, European Reference Network on Rare Endocrine Conditions. Endo-ERNs mission is to reduce and ultimately abolish inequalities in care for patients with rare endocrine disorders in Europe, through facilitating knowledge sharing and facilitating related healthcare and research.
https://endo-ern.eu/event/endo-ern-webinar-update-on-congenital-hyperinsulinism/
The HI Global Registry | Congenital Hyperinsulinism InternationalThe HI Global Registry | Congenital Hyperinsulinism International
Congenital Hyperinsulinism International (CHI) has developed a patient-reported registry called the HI Global Registry with its partners to improve the understanding of HI, and advance research for better treatments and patient care. The registry consists of a series of online surveys that asks the participant questions about the patients experience with the disorder over his or her lifetime. The data is stored on a secure cloud-based platform and made anonymous by removing any personal details that can identify the patient. This information is then combined with patient data from around the world to produce research reports that can be studied by disease experts and researchers. The HI Global Registry is open for registration now- click here to visit the registry website.. Patients and their legally authorized representatives will be able to participate in the HI Global Registry by registering online and consenting to participate in the study. After consenting, participants will be directed to ...
https://congenitalhi.org/higlobalregistry/
Cardiovascular markers during hyperinsulinemia in insulin resistant and insulin sensitive horses - Epsilon Archive for Student...Cardiovascular markers during hyperinsulinemia in insulin resistant and insulin sensitive horses - Epsilon Archive for Student...
Background: Insulin is an important metabolic hormone that also has cardiovasculat effects. Insulin resistance is characterized by decreased tissue sensitivity to insulin, and is a part of two important endocrine diseases in horses, Equine Metabolic Syndrome and Pituitary Pars Intermedia Dysfunction. Both diseases carry an increased risk for laminitis.. Decreased insulin sensitivity in people has been shown to lead to a decrease of the vasodilating effect of insulin. Increased baseline blood pressure and heart rate have also been seen in insulin resistant dogs and rats. The effect of induced hyperinsulinemia on cardiovascular markers such as heart rate, blood pressure and peripheral blood flow has been studied in healthy as well as insulin resistent people and laboratory animals. Studies regarding the effect of insulin resistance and induced hyperinsulinemia on cardiovascular markers in horses are scarce. The purpose of this study was to compare heart rate, blood pressure and hoof wall surface ...
https://stud.epsilon.slu.se/13091/
Obesity-associated hypertension. Hyperinsulinemia and renal mechanisms. | HypertensionObesity-associated hypertension. Hyperinsulinemia and renal mechanisms. | Hypertension
Hyperinsulinemia and insulin resistance have been postulated to link obesity and hypertension. Evidence supporting this concept derives mainly from epidemiological studies showing a correlation between insulin resistance, hyperinsulinemia, and blood pressure and from short-term studies suggesting that insulin has renal and cardiovascular actions that, if sustained, could elevate blood pressure. However, a cause-and-effect relation between insulin and hypertension has not been clearly established. Recent studies indicate that chronic hyperinsulinemia, similar to that found in obese hypertensive patients, did not raise blood pressure in normal dogs, even when renal excretory capability was reduced by prior removal of kidney mass. Chronic insulin infusion also failed to elevate blood pressure in dogs maintained on a high sodium intake and did not potentiate the long-term blood pressure responses to angiotensin II or norepinephrine. The presence or absence of insulin resistance may not be a major ...
http://hyper.ahajournals.org/content/19/1_Suppl/I45
Meet the Congenital Hyperinsulinism team | Great Ormond Street HospitalMeet the Congenital Hyperinsulinism team | Great Ormond Street Hospital
The Hyperinsulinism centre at Great Ormond Street Hospital has a specialist multi-disciplinary team of clinicians, surgeons, nurse specialists, clinical psychologist, researchers, dietician, speech and language therapist, social work and service coordinator ...
http://www.gosh.nhs.uk/medical-information/clinical-specialties/endocrinology-information-parents-and-visitors/conditions-we-treat/congenital-hyperinsulinism/meet-congenital-hyperinsulinism-team
Hyperinsulinism Clinical Presentation: History, Physical, CausesHyperinsulinism Clinical Presentation: History, Physical, Causes
Primary hyperinsulinism is a rare but important cause of hypoglycemia in infants and children. It is the most common cause of neonatal hypoglycemia that persists beyond the first few hours of life.
https://emedicine.medscape.com/article/921258-clinical
Association between hyperinsulinemia and hypertension in elderly subjects, independent of obesity, hyperglycemia, and...Association between hyperinsulinemia and hypertension in elderly subjects, independent of obesity, hyperglycemia, and...
TY - JOUR. T1 - Association between hyperinsulinemia and hypertension in elderly subjects, independent of obesity, hyperglycemia, and hypercholesterolemia. AU - Chan, P.. AU - Lin, T. H.. AU - Ko., J. T.. AU - Wang, C. H.. AU - Tsai, C. W.. AU - Chen, T. W.. PY - 1996. Y1 - 1996. N2 - The association between hyperinsulinemia and hypertension has attracted much attention in recent years. The aim of the study was to examine the extent to which hyperinsulinemia is associated with hypertension in the elderly Chinese and whether interventional therapy can improve hyperinsulinemia. This study included 144 institutionalized, healthy, nondiabetic elderly Chinese subjects were examined. Their ages ranged from 65 to 83 years, with a mean of 74 years. There were 72 men and 72 women. Forty-eight subjects were normotensive, and 96 were hypertensive; average body mass index (BMI) was 23. The hypertensive subjects could be divided into two groups: (A) untreated hypertensive (n = 48) and (B) treated ...
https://tmu.pure.elsevier.com/en/publications/association-between-hyperinsulinemia-and-hypertension-in-elderly-
Search of: gastric bypass | Congenital Hyperinsulinism - Modify Search - ClinicalTrials.govSearch of: gastric bypass | Congenital Hyperinsulinism - Modify Search - ClinicalTrials.gov
Note: The ClinicalTrials.gov search syntax is being updated to match the ClinicalTrials.gov application programming interface (API) search syntax. Documentation and interactive examples of the new syntax can be found on the ClinicalTrials.gov API web site. The current syntax will continue to work, but will not be updated to support new features ...
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Long-term treatment of persistent hyperinsulinaemic hypoglycaemia of infancy with diazoxide: a retrospective review of 77 cases...Long-term treatment of persistent hyperinsulinaemic hypoglycaemia of infancy with diazoxide: a retrospective review of 77 cases...
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
https://www.ncbi.nlm.nih.gov/pubmed/9727845
Familial persistent hyperinsulinaemic hypoglycaemia of infancy due to a novel glucokinase (GCK) activating mutation G68V -...Familial persistent hyperinsulinaemic hypoglycaemia of infancy due to a novel glucokinase (GCK) activating mutation G68V -...
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https://www.rdm.ox.ac.uk/publications/216917
Take a look at our Facebook page for news & infoTake a look at our Facebook page for news & info
The website for the Childrens Hyperinsulinism Charity | A site of support and resources for families and children living with congenital hyperinsulinism (CHI)
https://www.hyperinsulinism.co.uk/2-uncategorised/62-upcoming-events
ADRENERGIC MECHANISMS IN THE HYPERGLYCAEMIA AND HYPERINSULINAEMIA OF DIABETIC KK MICEADRENERGIC MECHANISMS IN THE HYPERGLYCAEMIA AND HYPERINSULINAEMIA OF DIABETIC KK MICE
O:13:\PanistOpenUrl\:36:{s:10:\\u0000*\u0000openUrl\;N;s:6:\\u0000*\u0000idc\;N;s:6:\\u0000*\u0000fmt\;s:7:\journal\;s:6:\\u0000*\u0000doi\;s:0:\\;s:6:\\u0000*\u0000pii\;s:0:\\;s:7:\\u0000*\u0000pmid\;s:0:\\;s:9:\\u0000*\u0000atitle\;s:85:\ADRENERGIC MECHANISMS IN THE HYPERGLYCAEMIA AND HYPERINSULINAEMIA OF DIABETIC KK MICE\;s:9:\\u0000*\u0000jtitle\;s:0:\\;s:9:\\u0000*\u0000stitle\;s:0:\\;s:7:\\u0000*\u0000date\;s:4:\1981\;s:9:\\u0000*\u0000volume\;s:0:\\;s:8:\\u0000*\u0000issue\;s:0:\\;s:8:\\u0000*\u0000spage\;s:0:\\;s:8:\\u0000*\u0000epage\;s:0:\\;s:8:\\u0000*\u0000pages\;s:0:\\;s:7:\\u0000*\u0000issn\;s:0:\\;s:8:\\u0000*\u0000eissn\;s:0:\\;s:9:\\u0000*\u0000aulast\;s:8:\FUJIMOTO\;s:10:\\u0000*\u0000aufirst\;s:1:\K\;s:9:\\u0000*\u0000auinit\;N;s:10:\\u0000*\u0000auinitm\;N;s:5:\\u0000*\u0000au\;a:2:{i:0;s:11:\SAKAGUCHI T\;i:1;s:4:\UI ...
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Hyperinsulinaemia: The unifying theory of chronic disease? | Lifestyle Before MedicationHyperinsulinaemia: The unifying theory of chronic disease? | Lifestyle Before Medication
I got some amazing news yesterday. A manuscript submitted to the journal Diabesity was accepted. You can read it here. Diabesity is a new journal, but it is Open access, so anyone can read the articles in it. In summary, high insulin levels are not only linked to diabetes and heart disease, but also to…
https://pharmacistcatherine.net/2015/11/26/hyperinsulinaemia-the-unifying-theory-of-chronic-disease/?like_comment=517&_wpnonce=761e0d1d70
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This study has investigated the effects of clamped hyperinsulinemic euglycemia and acute and repeated 2-h episodes of moderate hyperinsulinemic hypoglycemia (2.9 mmol/L) on endothelial function, fibrinolytic balance, and proinflammatory and proatherothrombotic mechanisms in healthy man. Our results demonstrate that acute hypoglycemia reduces endogenous NO-mediated endothelial vasodilation, activates inflammatory processes, impairs fibrinolytic balance, and increases proatherothrombotic mechanisms. Secondly, repeated episodes of hypoglycemia can further impair vascular function by additionally reducing both endogenous and exogenous NO-mediated endothelial function and increasing TAT complex formation.. Recent large randomized controlled trials investigating the effects of intensifying glucose control both in hospitals and in outpatient settings have demonstrated an association with hypoglycemia and severe cardiovascular outcomes and even death (5,8). The in vivo vascular pathophysiologic ...
http://diabetes.diabetesjournals.org/content/64/7/2571
Lupus low blood sugar - What Doctors Want You to KnowLupus low blood sugar - What Doctors Want You to Know
Helpful, trusted answers from doctors: Dr. Sneid on lupus low blood sugar: This is often a complication of diabetes therapy, and blood glucose management, but certain tumors, like insulinomas, among others, can cause this, and many of those patients have a family history of those tumors. Some others also have naturally low blood sugar, and that can be due to genetics. Congenital hyperinsulinism might be such a case, as might inborn errors of carbohydrate metabolism.
https://www.healthtap.com/topics/lupus-low-blood-sugar
Autoimmunity and Hyperinsulinemia, related diseases and genetic alterations | MENDELIAN.COAutoimmunity and Hyperinsulinemia, related diseases and genetic alterations | MENDELIAN.CO
AUTOIMMUNITY and HYPERINSULINEMIA related symptoms, diseases, and genetic alterations. Get the complete information with our medical search engine for
https://www.mendelian.co/symptoms/autoimmunity-and-hyperinsulinemia
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It is clearly recognized that patients with NIDDM have an increased risk for CHD. Recent data indicate that persons with glucose concentrations in the nondiabetic range also may be at higher risk for CHD. These associations may not represent cause and effect, however. Emerging data suggest that hyperglycemia and CHD may both arise from hyperinsulinemia/insulin resistance. In support of this hypothesis are studies showing that NIDDM and CHD have many risk factors in common, including age, elevated blood pressure, dyslipidemia, adiposity, and a central pattern of fat distribution. Moreover, these risk factors are frequent concomitants of hyperinsulinemia, itself a risk factor for CHD and perhaps for NIDDM. Although the duration of NIDDM has been infrequently related to risk of CHD, the authors hypothesize that duration of hyperinsulinemia/insulin resistance would be a more sensitive marker for risk of CHD. The relation of IDDM to CHD is a different situation. The etiological process leading to ...
http://care.diabetesjournals.org/content/15/9/1141
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HyperinsulinemiaHyperinsulinemia
Ferry, R.J. (2010). Hyperinsulinism "Medscape". Hyperinsulinemia Clément L, Poirier H, Niot I, Bocher V, Guerre-Millo M, Krief ... It can also occur in congenital hyperinsulinism, including nesidioblastosis. Hyperinsulinemia is associated with hypertension, ... Demirbilek, Hüseyin; Hussain, Khalid (2017-12-30). "Congenital Hyperinsulinism: Diagnosis and Treatment Update". Journal of ... "Congenital hyperinsulinism: current trends in diagnosis and therapy". Orphanet Journal of Rare Diseases. p. 63. doi:10.1186/ ...
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GlucokinaseGlucokinase
This creates hypoglycemia of varying patterns, including transient or persistent congenital hyperinsulinism, or fasting or ... Glaser B (2013-01-24). "Familial Hyperinsulinism". GeneReviews. Seattle WA: University of Washington, Seattle. PMID 20301549. ...
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List of OMIM disorder codesList of OMIM disorder codes
SLC16A1 Hyperinsulinism-hyperammonemia syndrome; 606762; GLUD1 Hyperkalemic periodic paralysis, type 2; 613345; SCN4A ...
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Idiopathic hypoglycemiaIdiopathic hypoglycemia
Hyperinsulinism Perry, Julian C.; Bourne, Blanche; Lester Henry, W. (January 1957). "Idiopathic Hypoglycemia in Childhood: ...
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Seale HarrisSeale Harris
Conclusions 1. Hyperinsulinism is a condition, perhaps a disease entity, with definite symptoms; i.e. those described as being ... His research on hyperinsulinism and its control brought international recognition to Harris, including the Distinguished ... 2. It seems probable that one of the causes of hyperinsulinism is the excessive ingestion of glucose-forming foods [...] "Seale ... Stephen Gyland of Tampa, Florida, suffered from hyperinsulinism and happened on Harris's article in the Journal of the American ...
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Sulfonylurea receptorSulfonylurea receptor
Fournet JC, Junien C (2004). "Genetics of congenital hyperinsulinism". Endocrine Pathology. 15 (3): 233-40. doi:10.1385/EP:15:3 ... SUR2A and SUR2B The SUR1 protein is coded by the ABCC8 gene and is associated with congenital hyperinsulinism and ...
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GLUDP5GLUDP5
1998). "Hyperinsulinism and hyperammonemia in infants with regulatory mutations of the glutamate dehydrogenase gene". N. Engl. ... 2001). "Hyperinsulinism/hyperammonemia syndrome in children with regulatory mutations in the inhibitory guanosine triphosphate- ... 2000). "Novel missense mutations in the glutamate dehydrogenase gene in the congenital hyperinsulinism-hyperammonemia syndrome ... "Congenital hyperinsulinism: molecular basis of a heterogeneous disease". Hum. Mutat. 13 (5): 351-61. doi:10.1002/(SICI)1098- ...
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Glutamate dehydrogenase 1Glutamate dehydrogenase 1
Hyperammonemia/hyperinsulinism (HA/HI) is associated with mild-to-moderate hyperammonemia and with relatively mild, late-onset ... Familial hyperinsulinism, linked to mutations in GLUD1, is characterized by hypoglycemia that ranges from severe neonatal-onset ... Individuals with autosomal recessive familial hyperinsulinism, caused by mutations in either ABCC8 or KCNJ11 (FHI-KATP), tend ... GeneReviews/NCBI/NIH/UW entry on Familial Hyperinsulinism Glutamate+dehydrogenase at the US National Library of Medicine ...
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Kir6.2Kir6.2
The gene encoding the channel is called KCNJ11 and mutations in this gene are associated with congenital hyperinsulinism. It is ... GeneReviews/NCBI/NIH/UW entry on Familial Hyperinsulinism GeneReviews/NCBI/NIH/UW entry on Permanent Neonatal Diabetes Mellitus ... Meissner T, Beinbrech B, Mayatepek E (1999). "Congenital hyperinsulinism: molecular basis of a heterogeneous disease". Hum. ... in diabetes mellitus and hyperinsulinism". Hum. Mutat. 27 (3): 220-31. doi:10.1002/humu.20292. PMID 16416420. S2CID 38053792. ...
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KetoneKetone
... due to causes other than hyperinsulinism; in various inborn errors of metabolism, and intentionally induced via a ketogenic ...
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Al Aynsley-GreenAl Aynsley-Green
September 2000). "A recessive contiguous gene deletion causing infantile hyperinsulinism, enteropathy and deafness identifies ... "Hyperinsulinism in short-chain L-3-hydroxyacyl-CoA dehydrogenase deficiency reveals the importance of β-oxidation in insulin ... "Hyperinsulinism in Infancy: From Basic Science to Clinical Disease". Physiological Reviews. 84 (1): 239-275. doi:10.1152/ ... "A recessive contiguous gene deletion causing infantile hyperinsulinism, enteropathy and deafness identifies the Usher type 1C ...
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Glossary of diabetesGlossary of diabetes
Hyperinsulinism Too high a level of insulin in the blood. This often involves a condition in which the body produces too much ...
https://en.wikipedia.org/wiki/Glossary_of_diabetes
HypoglycemiaHypoglycemia
When congenital hyperinsulinism is diffuse and refractory to medications, near-total pancreatectomy may be the treatment of ... Surgical removal of the overactive part of the pancreas is curative with minimal risk when hyperinsulinism is focal or due to a ... Some forms of congenital hyperinsulinism respond to diazoxide or octreotide. ... or 6 mg/kg/minute in children and adults are strong evidence for hyperinsulinism. In this context, this is referred to as the ...
https://en.wikipedia.org/wiki/Hypoglycemia
Whipples triadWhipple's triad
In an article entitled "The surgical therapy of hyperinsulinism", in J Internat Chir 3:237-276 (1938), he proposed that no ... Hyperinsulinism Hypoglycemia Causes of hypoglycemia Melmed, Shlomo (2016). Williams textbook of endocrinology (13 ed.). ...
https://en.wikipedia.org/wiki/Whipple's_triad
Neonatal hypoglycemiaNeonatal hypoglycemia
Congenital hyperinsulinism Hyperinsulinemic hypoglycemia Wong's nursing care of infants and children. Hockenberry, Marilyn J ...
https://en.wikipedia.org/wiki/Neonatal_hypoglycemia
Monocarboxylate transporter 1Monocarboxylate transporter 1
... in mouse pancreatic β-cells leads to relative hyperinsulinism during exercise". Diabetes. 61 (7): 1719-25. doi:10.2337/db11- ... Overexpression of MCT1 in pancreatic beta cells leads to hyperinsulinism during exercise. ENSG00000281917 GRCh38: Ensembl ...
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Neonatal diabetesNeonatal diabetes
Mutations that occur in ABCC8 are associated with congential hyperinsulinism and PNDM or TNDM. Patients that have mutations in ...
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CrampCramp
Due to Diabetogenic Hyperinsulinism: Observations on 131 Patients". Journal of the American Geriatrics Society. 13 (7): 602-38 ...
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Three subtypes PMM2-CDG, PMI-CDG, ALG6-CDG can cause congenital hyperinsulinism with hyperinsulinemic hypoglycemia in infancy. ...
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In the 1920s, after the discovery of insulin and its use in the treatment of diabetics, hyperinsulinism was suspected to be a ... A pioneering description of hyperinsulinism as a cause of hypoglycemia was published by Seale Harris in 1924. The first report ...
https://en.wikipedia.org/wiki/Insulinoma
NesidioblastosisNesidioblastosis
Most congenital hyperinsulinism is now known to be caused by different mechanisms than excessive proliferation of beta cells in ... In recent years, the term has been revived to describe a form of acquired hyperinsulinism with beta cell hyperplasia found in ... Clancy T, Moore F, Zinner M (2006). "Post-gastric bypass hyperinsulinism with nesidioblastosis: subtotal or total ... Congenital hyperinsulinism Neonatal hypoglycemia Raffel A, Krausch MM, Anlauf M, Wieben D, Braunstein S, Klöppel G, Röher H, ...
https://en.wikipedia.org/wiki/Nesidioblastosis
USH1CUSH1C
"A recessive contiguous gene deletion causing infantile hyperinsulinism, enteropathy and deafness identifies the Usher type 1C ...
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Coffin-Siris syndromeCoffin-Siris syndrome
... hepatomegaly and hyperinsulinism caused by a mutation in the ARID1B gene". European Journal of Human Genetics. 22 (11): 1327-9 ...
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Cedartown High SchoolCedartown High School
Harris' most celebrated accomplishments were his 1924 hypothesis of hyperinsulinism as a cause of spontaneous hypoglycemia. He ...
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Hydroxyacyl-Coenzyme A dehydrogenaseHydroxyacyl-Coenzyme A dehydrogenase
GeneReviews/NCBI/NIH/UW entry on Familial Hyperinsulinism Overview of all the structural information available in the PDB for ... "Next-generation sequencing reveals deep intronic cryptic ABCC8 and HADH splicing founder mutations causing hyperinsulinism by ...
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Hyperinsulinemic hypoglycemiaHyperinsulinemic hypoglycemia
Hyperinsulinism due to diffuse overactivity of beta cells, such as in many of the forms of congenital hyperinsulinism, and more ... Hypoglycemia due to endogenous insulin Congenital hyperinsulinism Transient neonatal hyperinsulinism (mechanism not known) ... When congenital hyperinsulinism is due to focal defects of the insulin-secretion mechanism, surgical removal of that part of ... Detectable amounts of insulin are abnormal and indicate that hyperinsulinism is likely to be the cause. Other aspects of the ...
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Pancreatic cancerPancreatic cancer
The first case of hyperinsulinism due to a tumor of this type was reported in 1927. Recognition of a non-insulin-secreting type ...
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DiazoxideDiazoxide
... or congenital hyperinsulinism. Diazoxide acts as a positive allosteric modulator of the AMPA and kainate receptors, suggesting ...
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Glutamate dehydrogenaseGlutamate dehydrogenase
... and lead to hyperinsulinism-hyperammonemia syndrome. Allosteric regulation: This protein may use the morpheein model of ...
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NesidioblastomaNesidioblastoma
... long-standing hypoglycemia due to hyperinsulinism. Surgical removal corrected the low glucose problems. There is no rigorous ...
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Congenital hyperinsulinism: MedlinePlus GeneticsCongenital hyperinsulinism: MedlinePlus Genetics
Congenital hyperinsulinism is a condition that causes individuals to have abnormally high levels of insulin, which is a hormone ... Genetic Testing Registry: Hyperinsulinism due to glucokinase deficiency *Genetic Testing Registry: Hyperinsulinism- ... Mutations in at least nine genes have been found to cause congenital hyperinsulinism. Mutations in the ABCC8 gene are the most ... Congenital hyperinsulinism is a condition that causes individuals to have abnormally high levels of insulin, which is a hormone ...
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Familial focal congenital hyperinsulinism. - PubMed - NCBIFamilial focal congenital hyperinsulinism. - PubMed - NCBI
Familial focal congenital hyperinsulinism.. Ismail D1, Smith VV, de Lonlay P, Ribeiro MJ, Rahier J, Blankenstein O, Flanagan SE ... Congenital hyperinsulinism (CHI) is a cause of persistent hypoglycemia. Histologically, there are two subgroups, diffuse and ...
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Hyperinsulinism: Background, Pathophysiology, EpidemiologyHyperinsulinism: Background, Pathophysiology, Epidemiology
Primary hyperinsulinism is a rare but important cause of hypoglycemia in infants and children. It is the most common cause of ... encoded search term (Hyperinsulinism) and Hyperinsulinism What to Read Next on Medscape. Medscape Consult. ... Several genetic causes of persistent hyperinsulinism have been identified. [2, 3, 4, 5, 6, 7, 8, 9, 10] See the image below. ... Primary hyperinsulinism is a rare but important cause of hypoglycemia in infants and children. It is the most common cause of ...
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Hyperinsulinism - WikipediaHyperinsulinism - Wikipedia
Hyperinsulinism refers to an above normal level of insulin in the blood of a person or animal. Normal insulin secretion and ... Hyperinsulinism can be associated with several types of medical problems, which can be roughly divided into two broad and ... Hyperinsulinism due to reduced insulin sensitivity is usually asymptomatic. In contrast, hyperinsulinemic hypoglycemia can ...
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Surgery for Congenital Hyperinsulinism | SpringerLinkSurgery for Congenital Hyperinsulinism | SpringerLink
Our multidisciplinary approach to patients with congenital hyperinsulinism can distinguish focal from diffuse disease, localize ... Characterization of hyperinsulinism in infancy assessed with PET and 18F-fluoro-L-DOPA. J Nucl Med. 2005;46:560-6.PubMedGoogle ... Congenital hyperinsulinism and the surgeon: lessons learned over 35 years. J Pediatr Surg. 1999;34:786-92.CrossRefGoogle ... Accuracy of PET/CT scan in the diagnosis of the focal form of congenital hyperinsulinism. J Pediatr Surg. 2013a;48:388-93. ...
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Congenital hyperinsulinism - WikipediaCongenital hyperinsulinism - Wikipedia
A GIR above 8 mg/kg/minute in infancy suggests hyperinsulinism. A third form of evidence suggesting hyperinsulinism is a rise ... Diffuse hyperinsulinism FHI-KATP FHI-HADH FHI-UCP2 FHI-HNF4A Glucokinase mutation Hyperammonemic hyperinsulinism (glutamate ... Congenital hyperinsulinism is a medical term referring to a variety of congenital disorders in which hypoglycemia is caused by ... The cause of congenital hyperinsulinism has been linked to anomalies in nine genes. The diffuse form of this condition is ...
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Hyperinsulinism Due to Islet-cell Adenoma | The BMJHyperinsulinism Due to Islet-cell Adenoma | The BMJ
Hyperinsulinism Due to Islet-cell Adenoma Br Med J 1949; 1 :680 ... Hyperinsulinism Due to.... *Hyperinsulinism Due to Islet-cell ... Hyperinsulinism Due to Islet-cell Adenoma. Br Med J 1949; 1 doi: https://doi.org/10.1136/bmj.1.4606.680-a (Published 16 April ...
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Hyperinsulinism Clinical Presentation: History, Physical, CausesHyperinsulinism Clinical Presentation: History, Physical, Causes
Primary hyperinsulinism is a rare but important cause of hypoglycemia in infants and children. It is the most common cause of ... encoded search term (Hyperinsulinism) and Hyperinsulinism What to Read Next on Medscape. Related Conditions and Diseases. * ... Exercise-induced hyperinsulinism (EIHI): Exercise-induced hyperinsulinism (EIHI) is characterized by inappropriate insulin ... Hyperinsulinism-hyperammonemia (HH) syndrome due to GLUD1 mutation, as follows:. *. GLUD1 mutations reported to date have been ...
https://emedicine.medscape.com/article/921258-clinical
Hyperinsulinism? - BabyCenterHyperinsulinism? - BabyCenter
Josie will be 8 weeks old tomorrow and today she was diagnosed with hyperinsulinism. Shes had a hard time regulating her blood ... Josie will be 8 weeks old tomorrow and today she was diagnosed with hyperinsulinism. Shes had a hard time regulating her blood ...
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Sandostatine® LP and Hyperinsulinism - Tabular View - ClinicalTrials.govSandostatine® LP and Hyperinsulinism - Tabular View - ClinicalTrials.gov
Sandostatine® LP and Hyperinsulinism. The safety and scientific validity of this study is the responsibility of the study ... Sandostatine® LP and Hyperinsulinism. Official Title ICMJE Replace Sandostatine® in Three Daily Subcutaneous Injections by a ... Congenital Hyperinsulinism. Intervention ICMJE Drug: Sandostatine LP Intramuscular injection of Sandostatine LP, once per month ... Ten children who have a diffuse form of hyperinsulinism have been treated in our department by Sandostatine® given in three ...
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Hyperinsulinism. Causes and mechanisms]Hyperinsulinism. Causes and mechanisms]
... Presse Med. 1992 Sep 9;21(28):1312-7. ...
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Hyperinsulinism Center | Cook ChildrensHyperinsulinism Center | Cook Children's
Paul Thornton, Cook Childrens congenital hyperinsulinism (CHI) program is one of only two in the nation to offer the ... What is hyperinsulinism?. Congenital hyperinsulinism is a rare condition that interferes with the bodys ability to regulate ... Cook Childrens Hyperinsulinism Center uses a specialized team approach to treat hyperinsulinism (HI). Hyperinsulinism affects ... Hyperinsulinism is genetic, and there are many different types. Depending on the type of hyperinsulinism your child has, ...
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Search of: glucose | Congenital Hyperinsulinism - Modify Search - ClinicalTrials.govSearch of: glucose | Congenital Hyperinsulinism - Modify Search - ClinicalTrials.gov
Fill in any or all of the fields below. Click on the label to the left of each search field for more information or read the Help ...
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Search of: gastric bypass | Congenital Hyperinsulinism - Modify Search - ClinicalTrials.govSearch of: gastric bypass | Congenital Hyperinsulinism - Modify Search - ClinicalTrials.gov
Note: The ClinicalTrials.gov search syntax is being updated to match the ClinicalTrials.gov application programming interface (API) search syntax. Documentation and interactive examples of the new syntax can be found on the ClinicalTrials.gov API web site. The current syntax will continue to work, but will not be updated to support new features ...
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Hyperinsulinism | CTDHyperinsulinism | CTD
Hyperinsulinism Synonyms Compensatory Hyperinsulinemia , Endogenous Hyperinsulinism , Exogenous Hyperinsulinism , ... Hyperinsulinemia , Hyperinsulinemia, Compensatory , Hyperinsulinism, Endogenous , Hyperinsulinism, Exogenous Definition A ... Etiology of hyperinsulinism varies, including hypersecretion of a beta cell tumor (INSULINOMA); autoantibodies against insulin ...
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Hyperinsulinism - Renal and Urology NewsHyperinsulinism - Renal and Urology News
Surgery for diffuse hyperinsulinism carries a risk of diabetes. Surgery for focal hyperinsulinism in experienced centers should ... Hyperinsulinism is the most common hypoglycemic disorder in infants and neonates. Transient neonatal hyperinsulinism is common ... Diazoxide is the drug of choice for long-term management of hyperinsulinism. Once a diagnosis of hyperinsulinism has been made ... In cases of focal hyperinsulinism, surgical resection can be curative. Near-total pancreatectomy for diffuse hyperinsulinism ...
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Diffuse Hyperinsulinism: Maxs Story | Childrens Hospital of PhiladelphiaDiffuse Hyperinsulinism: Max's Story | Children's Hospital of Philadelphia
After surgery to treat his diffuse hyperinsulinism, hes thriving. ... Frustration and fear led Maxs parents to bring him across the country to CHOPs Congenital Hyperinsulinism Center. ... Medication didnt raise them, and when a PET scan indicated Max had diffuse hyperinsulinism (HI) disease, the doctors at the HI ...
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Utility of [F-18] fluoroDOPA for Neonatal Hyperinsulinism - Full Text View - ClinicalTrials.govUtility of [F-18] fluoroDOPA for Neonatal Hyperinsulinism - Full Text View - ClinicalTrials.gov
Congenital Hyperinsulinism Hyperinsulinism Persistent Hyperinsulinemic Hypoglycemia of Infancy CHI PHHI Drug: F-DOPA Radiation ... Congenital Hyperinsulinism. Hyperinsulinism. Persistent Hyperinsulinemic Hypoglycemia of Infancy. CHI. PHHI. F-DOPA. L-fluoro- ... Children diagnosed with hyperinsulinism who have had partial pancreas removal but still display signs of hyperinsulinism. ... Hyperinsulinism. Congenital Hyperinsulinism. Hypoglycemia. Glucose Metabolism Disorders. Metabolic Diseases. Pancreatic ...
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Congenital hyperinsulinism | Great Ormond Street HospitalCongenital hyperinsulinism | Great Ormond Street Hospital
Medical information on Hyperinsulinism from Great Ormond Street Hospital. ... Congenital hyperinsulinism. Congenital hyperinsulinism. This page explains about congenital hyperinsulinism (CHI), which is ... Congenital hyperinsulinism F0129 A5 col FINAL Aug19.pdf. Congenital hyperinsulinism leaflet (1.35 MB) ... Hyperinsulinism real stories. Hear from two parents about their experiences of looking after children with hyperinsulinism. ...
https://www.gosh.nhs.uk/conditions-and-treatments/conditions-we-treat/hyperinsulinism
Brandon infant receives lifesaving care for hyperinsulinism | tbo.comBrandon infant receives lifesaving care for hyperinsulinism | tbo.com
Brandon infant receives lifesaving care for hyperinsulinism. Jonathan Baron soothes his baby Colton Robert Baron with kisses ... Colton was diagnosed with congenital hyperinsulinism, a rare group of disorders in which the body produces too much insulin, ... 31 by air ambulance to the Congenital Hyperinsulinism Center at the Childrens Hospital in Philadelphia, one of the few places ... worldwide that specialize in identifying various types of hyperinsulinism and performing corrective surgery. ...
http://www.tbo.com/brandon/brandon-infant-receives-lifesaving-care-for-hyperinsulinism-20140210/
Congenital Hyperinsulinism News and Updates | Childrens Hospital of PhiladelphiaCongenital Hyperinsulinism News and Updates | Children's Hospital of Philadelphia
Congenital Hyperinsulinism News and Updates. 1 - 10 of 28. Meet HI Centers Newest Team Member: Genetic counselor Victoria ... CHOPs Congenital Hyperinsulinism Center Celebrates 20 Years and 500 Surgeries Published on Oct 05, 2018 in CHOP News ... Congenital Hyperinsulinism and Beckwith-Wiedemann Syndrome: Alinas Story Published on Jun 25, 2020 in HI Hope ... Pioneers in Hyperinsulinism: Yesterday, Today and Tomorrow Published on Sep 18, 2018 in Breakthrough Report ...
https://www.chop.edu/conditions-diseases/congenital-hyperinsulinism/news
Genotype and phenotype correlations in 417 children with congenital hyperinsulinismGenotype and phenotype correlations in 417 children with congenital hyperinsulinism
... J Clin Endocrinol Metab. 2013 Feb;98(2): ... Context: Hypoglycemia due to congenital hyperinsulinism (HI) is caused by mutations in 9 genes. ...
https://pubmed.ncbi.nlm.nih.gov/23275527/?dopt=Abstract
Hyperinsulinism - Hyperinsulinemia Summary Report | CureHunterHyperinsulinism - Hyperinsulinemia Summary Report | CureHunter
Etiology of hyperinsulinism varies, including hypersecretion of a beta cell tumor (INSULINOMA); autoantibodies against insulin ... Hyperinsulinism: A syndrome with excessively high INSULIN levels in the BLOOD. It may cause HYPOGLYCEMIA. ... Exogenous Hyperinsulinism; Hyperinsulinemia, Compensatory; Hyperinsulinism, Endogenous; Hyperinsulinism, Exogenous ... Hyperinsulinism (Hyperinsulinemia). Subscribe to New Research on Hyperinsulinism A syndrome with excessively high INSULIN ...
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Impaired Glucose Tolerance in Adolescent Offspring of Diabetic Mothers: Relationship to fetal hyperinsulinism | Diabetes CareImpaired Glucose Tolerance in Adolescent Offspring of Diabetic Mothers: Relationship to fetal hyperinsulinism | Diabetes Care
Impaired Glucose Tolerance in Adolescent Offspring of Diabetic Mothers: Relationship to fetal hyperinsulinism. ... Impaired Glucose Tolerance in Adolescent Offspring of Diabetic Mothers: Relationship to fetal hyperinsulinism ... Impaired Glucose Tolerance in Adolescent Offspring of Diabetic Mothers: Relationship to fetal hyperinsulinism ... Impaired Glucose Tolerance in Adolescent Offspring of Diabetic Mothers: Relationship to fetal hyperinsulinism ...
https://care.diabetesjournals.org/content/18/5/611?ijkey=fc7d04c9543c03772957c0b5b75ce7205b9982ba&keytype2=tf_ipsecsha
Perioperative Management of Hyperinsulinism | Springer for Research & DevelopmentPerioperative Management of Hyperinsulinism | Springer for Research & Development
The care of children undergoing pancreatectomies for hyperinsulinism presents unique challenges. In addition to ensuring ... Hyperinsulinism in the neonate. Clin Perinatol. 2018;45(1):61-74.CrossRefGoogle Scholar ... Congenital hyperinsulinism - a review of the disorder and a discussion of the anesthesia management. Paediatr Anaesth. 2007;17( ... In: De León-Crutchlow D., Stanley C. (eds) Congenital Hyperinsulinism. Contemporary Endocrinology. Humana Press, Cham. * First ...
https://rd.springer.com/chapter/10.1007%2F978-3-030-02961-6_10
Ginkgo biloba extract enhances glucose tolerance in hyperinsulinism-induced hepatic cells | Herb NewsGinkgo biloba extract enhances glucose tolerance in hyperinsulinism-induced hepatic cells | Herb News
Ginkgo biloba extract enhances glucose tolerance in hyperinsulinism-induced hepatic cells. By Teresa Koby on September 28, 2010 ... In the current study, we tested the hypothesis that Ginkgo biloba extract (GBE) prevented hyperinsulinism-induced glucose ...
http://www.herbs.org/herbnews/2010/09/ginkgo-biloba-extract-enhances-glucose-tolerance-in-hyperinsulinism-induced-hepatic-cells/
Laparoscopic Diagnosis and Cure of Hyperinsulinism in Two Cases of Focal Adenomatous Hyperplasia in Infancy | ELECTRONIC...Laparoscopic Diagnosis and Cure of Hyperinsulinism in Two Cases of Focal Adenomatous Hyperplasia in Infancy | ELECTRONIC...
The presumed incidence may be as high as 30% to 60% of cases of congenital hyperinsulinism.6,9,10 Diffuse hyperinsulinism and ... Cure of hypoglycemic hyperinsulinism by enucleation of a focal islet cell adenomatous hyperplasia. J Pediatr Surg.1997;32 :1526 ... Hyperinsulinism of infancy: towards an understanding of unregulated insulin release. Arch Dis Child Fetal Neonatal Ed.2000;82 : ... Because congenital hyperinsulinism may be caused either by diffuse involvement of pancreatic β-cells or by a focal cluster of ...
http://pediatrics.aappublications.org/content/114/4/e520
Hyperinsulinism | Svensk MeSHHyperinsulinism | Svensk MeSH
Hyperinsulinism. Hyperinsulinism. Svensk definition. Ett syndrom med onormalt höga insulinhalter i blodet. Det kan ge upphov ... Hyperinsulinemia - Exogenous Hyperinsulinism - Hyperinsulinism, Exogenous - Compensatory Hyperinsulinemia - Hyperinsulinemia, ... Etiology of hyperinsulinism varies, including hypersecretion of a beta cell tumor (INSULINOMA); autoantibodies against insulin ...
https://mesh.kib.ki.se/term/D006946
Altmetric - Congenital HyperinsulinismAltmetric - Congenital Hyperinsulinism
The data shown below were compiled from readership statistics for 2 Mendeley readers of this research output. Click here to see the associated Mendeley record. ...
https://www.altmetric.com/details/53773745/chapter/53773781
Meet the Congenital Hyperinsulinism team | Great Ormond Street HospitalMeet the Congenital Hyperinsulinism team | Great Ormond Street Hospital
Meet the Congenital Hyperinsulinism team. Meet the Congenital Hyperinsulinism team. The Hyperinsulinism centre at Great Ormond ...
http://www.gosh.nhs.uk/medical-information/clinical-specialties/endocrinology-information-parents-and-visitors/conditions-we-treat/congenital-hyperinsulinism/meet-congenital-hyperinsulinism-team
Patients with congenital hyperinsulinismInfancyNeonatal hyperinsulinismMutationsMutationDiazoxideChildren's Hospital ofForms of congenitalLiving with congenital hyperinsulinismGenesChildren with hyperinsulinismManagement of HyperinsulinismHyperammonemiaPancreasPancreatectomyPancreaticTransient hyperinsulinismGlucoseClinicalGlutamateTreatment of congenital hyperinsulinism2017Cause of persistent hypoglycemiaPathophysiologyHypoglycaemiaInsulin ResistanceFetalSevereSyndromeDeficiencyDiabetesDiagnosticForm of HyperinsulinismTypes of hyperinsulinismDiagnosis of hyperinsulinismNeonates with hyperinsulinismHyperinsulinemia or HyperinsulinismFamilialInfants with congenitalDiffuse formHyperinsulinemicTreat hyperinsulinismPersistent hyperinsulinismNewbornsNeonate
Patients with congenital hyperinsulinism5
  • Our multidisciplinary approach to patients with congenital hyperinsulinism can distinguish focal from diffuse disease, localize focal lesions, and permit partial pancreatectomy with cure in almost all patients. (springer.com)
  • XOMA is conducting Phase 2 development activities for 358 in patients with congenital hyperinsulinism (CHI) and in patients with hypoglycemia post-bariatric surgery (PBS). (xoma.com)
  • Khalid has treated over 500 patients with congenital hyperinsulinism from all over the world. (hyperinsulinismgenes.org)
  • Kevin oversees the MODY genetic testing service and is involved in the routine genetic testing for UK patients with congenital hyperinsulinism. (hyperinsulinismgenes.org)
  • Becky is part of the team who perform the laboratory analysis for patients with congenital hyperinsulinism. (hyperinsulinismgenes.org)
Infancy22
  • Characterization of hyperinsulinism in infancy assessed with PET and 18F-fluoro-L-DOPA. (springer.com)
  • Noninvasive diagnosis of focal hyperinsulinism of infancy with [18F]-DOPA positron emission tomography. (springer.com)
  • Surgical management of congenital hyperinsulinism of infancy. (springer.com)
  • A GIR above 8 mg/kg/minute in infancy suggests hyperinsulinism. (wikipedia.org)
  • Classification of hyperinsulinism in infancy is described below. (medscape.com)
  • Also, by consensus most international teams taking care of hyperinsulinism in infancy propose this treatment to their patients. (clinicaltrials.gov)
  • Persistent hyperinsulinemic hypoglycemia of infancy or congenital hyperinsulinism of the neonate is a rare condition that may cause severe neurologic damage if the disease is unrecognized or inadequately treated. (aappublications.org)
  • Persistent hyperinsulinemic hypoglycemia of infancy (PHHI), or congenital hyperinsulinism, is a rare disease characterized by inappropriate insulin secretion in the presence of hypoglycemia. (aappublications.org)
  • Congenital hyperinsulinism of infancy (CHI) is characterized by severe hypoglycemia due to dysregulated insulin secretion, associated with either focal or diffuse pathology of the endocrine pancreas. (diabetesjournals.org)
  • Congenital hyperinsulinism of infancy (CHI) is a severe disease that carries a high risk of neurological complications secondary to deep uncontrollable hypoglycemia ( 1 , 2 ). (diabetesjournals.org)
  • Hyperinsulinism of infancy associated with a novel splice site mutation in the SCHAD gene. (sigmaaldrich.com)
  • Hyperinsulinism in infancy is one of the most difficult problems to manage in contemporary paediatric endocrinology. (bmj.com)
  • Hyperinsulinism is the most common cause of persistent or recurrent hypoglycaemia in infancy. (bmj.com)
  • Hyperinsulinaemic hypoglycaemia has previously masqueraded under a variety of different descriptive names, including "idiopathic" hypoglycaemia of childhood, leucine sensitive hypoglycaemia, neonatal insulinoma, pancreatic microadenomatosis, nesidioblastosis, persistent hyperinsulinaemic hypoglycaemia of infancy, and congenital hyperinsulinism. (bmj.com)
  • Hyperinsulinism of infancy is caused by inappropriate insulin secretion in pancreatic β-cells, even when blood glucose is low. (portlandpress.com)
  • Several molecular defects are known to cause hyperinsulinism of infancy, such as K ATP channelopathies and regulatory defects of glucokinase and glutamate dehydrogenase. (portlandpress.com)
  • Hyperinsulinism most commonly presents in the newborn period, but can also present during infancy and childhood. (hyperinsulinismgenes.org)
  • Congenital hyperinsulinism of infancy is a disease of newborn children where life-threatening hypoglycemia (low blood glucose) arises because insulin secretion from the pancreas is inappropriately elevated. (uib.no)
  • Example of a family with congenital hyperinsulinism of infancy. (uib.no)
  • Congenital Hyperinsulinism (HI) is the main cause of persistent hypoglycemia in the newborn and infancy. (heraldopenaccess.us)
  • Hardy, OT & Stanley, CA 2006, Hyperinsulinism of infancy: Localization of focal forms . (elsevier.com)
  • Stanley, Charles A. / Hyperinsulinism of infancy : Localization of focal forms . (elsevier.com)
Neonatal hyperinsulinism3
  • Transient neonatal hyperinsulinism is common due to perinatal stress, including birth asphyxia, preeclampsia, and intrauterine growth retardation. (renalandurologynews.com)
  • Transient neonatal hyperinsulinism can last for several days to weeks after birth and can be treated with frequent feedings or diazoxide depending on the severity. (renalandurologynews.com)
  • Neonatal hyperinsulinism (HI) is a genetic disorder of pancreatic beta-cells characterized by failure to suppress insulin secretion in the presence of hypoglycemia, resulting in brain damage or death if not adequately treated. (diabetesjournals.org)
Mutations14
  • Gene mutations that cause congenital hyperinsulinism lead to over-secretion of insulin from beta cells. (medlineplus.gov)
  • Mutations in at least nine genes have been found to cause congenital hyperinsulinism. (medlineplus.gov)
  • Less frequently, mutations in the KCNJ11 gene have been found in people with congenital hyperinsulinism. (medlineplus.gov)
  • In terms of the mechanism of congenital hyperinsulinism one sees that channel trafficking requires KATP channels need the shielding of ER retention signal.E282K prevents the KATP channel surface expression, the C-terminus (SUR1 subunit) is needed in KATP channel mechanism.R1215Q mutations (ABCC8 gene) affect ADP gating which in turn inhibits KATP channel. (wikipedia.org)
  • Mutations in two genes encoding the potassium channels, SUR1 and KIR6.2, are responsible for hyperinsulinism resistant to diazoxide. (clinicaltrials.gov)
  • Congenital forms of hyperinsulinism are associated with recessive, dominant, or sporadic genetic defects in insulin regulation--particularly mutations of the beta-cell ATP-dependent potassium channel. (renalandurologynews.com)
  • Hypoglycemia due to congenital hyperinsulinism (HI) is caused by mutations in 9 genes. (nih.gov)
  • The majority of cases with persistent hyperinsulinism are due to mutations of a single gene. (hyperinsulinismgenes.org)
  • Diagnostic screening is offered for mutations in the ABCC8 gene as well as in other genetic causes of congenital hyperinsulinism ( KIR6.2/ KCNJ11 , GLUD1 , GCK , HADH, HNF4A) . (uib.no)
  • Loss of channel function because of mutations in Kir6.2 or its associated regulatory subunit, sulfonylurea receptor 1, causes congenital hyperinsulinism (CHI), a neonatal disease characterized by persistent insulin secretion despite severe hypoglycemia. (elsevier.com)
  • Mutations in the genes encoding these proteins are the most common cause of congenital hyperinsulinism (CHI). (ox.ac.uk)
  • Compound heterozygous mutations in congenital hyperinsulinism result in complex interactions. (elsevier.com)
  • These mutations may also cause focal hyperinsulinism in which there is an area of β-cell adenomatosis due to loss of heterozygosity for the maternal 11p region and expression of a paternally derived KATP channel mutation (3). (elsevier.com)
  • Relevance Currently, there are no effective medical therapies for children with congenital hyperinsulinism due to inactivating mutations of the KATP channels and most affected children require pancreatectomy for intractable hypoglycemia. (grantome.com)
Mutation8
  • Congenital hyperinsulinism often presents as hypoglycemia in the neonatal period, but it can present later depending on the type and severity of the underlying mutation. (renalandurologynews.com)
  • Hyperinsulinism caused by paternal-specific inheritance of a recessive mutation in the sulfonylurea-receptor gene. (diabetesjournals.org)
  • We report a case of a novel splice site mutation in the short-chain 3-hydroxyacyl-CoA dehydrogenase (SCHAD) gene associated with hyperinsulinism. (sigmaaldrich.com)
  • 1) Hussain et al An ABCC8 gene mutation and mosaic uniparental isodisomy resulting in atypical diffuse congenital hyperinsulinism. (hyperinsulinismgenes.org)
  • We have also characterized the mutation spectrum of the sulfonylurea receptor-1 gene (ABCC8), which is the most commonly mutated gene causing congenital hyperinsulinism in Norway. (uib.no)
  • Aim 2 will extend the search for defects in novel candidate genes in our large series of children with diazoxide responsive hyperinsulinism that have no identifiable mutation. (grantome.com)
  • Congenital hyperinsulinism caused by hexokinase I expression or glucokinase-activating mutation in a subset of β-cells. (naver.com)
  • Dominantly inherited hyperinsulinism caused by a mutation in the sulfonylurea receptor type 1. (ox.ac.uk)
Diazoxide8
  • Diazoxide, a potassium channel agonist, is the drug of choice for treatment of hyperinsulinism. (renalandurologynews.com)
  • Some infants with congenital hyperinsulinism are severely affected and require surgery if they are unresponsive to diazoxide. (renalandurologynews.com)
  • Children diagnosed with hyperinsulinism who are successfully managed with diazoxide, octreotide, other medications,and/or tube feedings. (clinicaltrials.gov)
  • Hyperinsulism due to glucokinase deficiency (HIGCK) is a form of diazoxide-sensitive diffuse hyperinsulinism (see this term), caused by a lowered threshold for insulin release, characterized by an excessive/ uncontrolled insulin secretion (inappropriate for the level of glycemia) and recurrent episodes of profound hypoglycemia induced by fasting and protein rich meals, requiring rapid and intensive treatment to prevent neurological sequelae. (nih.gov)
  • The hyperinsulinism was successfully treated with diazoxide. (eur.nl)
  • Congenital hyperinsulinism, to reduce insulin secretion where diazoxide has been unsuccessful. (aetna.com)
  • Please note: Any gene in the Tier 1 Panel: Diazoxide Unresponsive Hyperinsulinism Panel can also be ordered individually. (uchicago.edu)
  • Most of the cases with severe hyperinsulinism do not respond to medical therapy with diazoxide, octreotide (Fig. 27B.1), or continuous feedings and require near-total pancreatectomy to control hypoglycemia. (elsevier.com)
Children's Hospital of3
  • Two generations of the Parkes family have come to Children's Hospital of Philadelphia for treatment for hyperinsulinism (HI). (chop.edu)
  • 3 months, with congenital hyperinsulinism managed by Children's Hospital of Philadelphia over a 3.5-year period. (bmj.com)
  • Little Óðinn was born with a potentially life-threatening disease, congenital hyperinsulinism (HI) , but he came to Children's Hospital of Philadelphia (CHOP) from his native Iceland for treatment and is now cured. (chop.edu)
Forms of congenital7
  • Intraoperative sonography: a technique for localizing focal forms of congenital hyperinsulinism in the pancreas. (springer.com)
  • Rahier J, Guiot Y, Sempoux C. Morphologic analysis of focal and diffuse forms of congenital hyperinsulinism. (springer.com)
  • citation needed] Other presentations are: Dizziness Intellectual disability Hypoglycemic coma Cardiomegaly The variable ages of presentations and courses suggest that some forms of congenital hyperinsulinism, especially those involving abnormalities of KATP channel function, can worsen or improve with time. (wikipedia.org)
  • The variable ages of presentations and courses suggest that some forms of congenital hyperinsulinism, especially those involving abnormalities of K ATP channel function, can gradually worsen or improve with time. (chemeurope.com)
  • The long-term goals of the research are to identify genotype- phenotype correlations in these disorders to guide diagnosis and treatment and to uncover new forms of congenital hyperinsulinism. (grantome.com)
  • Beyond the 2 classical forms of congenital hyperinsulinism, focal and diffuse, we report our experience on the surgical treatment of atypical forms. (naver.com)
  • Morphologic analysis of focal and diffuse forms of congenital hyperinsulinism. (uclouvain.be)
Living with congenital hyperinsulinism1
  • In honor of Rare Disease Day, February 28, 2015, Congenital Hyperinsulinism International (CHI) held the inaugural Sugar Shindig in Austin, Texas in support of patients living with congenital hyperinsulinism. (congenitalhi.org)
Genes3
  • The cause of congenital hyperinsulinism has been linked to anomalies in nine genes. (wikipedia.org)
  • Her interests include analysing genotype/phenotype relationships and employing next generation sequencing technologies to search for novel hyperinsulinism genes ( University profile ). (hyperinsulinismgenes.org)
  • Prof Khalid Hussain is the lead clinician on the hyperinsulinism genes research project. (hyperinsulinismgenes.org)
Children with hyperinsulinism4
  • Many infants and children with hyperinsulinism have a genetic disorder of insulin regulation, which can be recessive, dominant, or sporadic. (renalandurologynews.com)
  • In this study, researchers will test the possibility of using PET with F-DOPA in the diagnosis of children with hyperinsulinism. (clinicaltrials.gov)
  • Children with hyperinsulinism are at risk for feeding disorders. (chop.edu)
  • This created the first multidisciplinary team dedicated to the care of children with hyperinsulinism. (chop.edu)
Management of Hyperinsulinism1
  • Lord K., Duran M., Rintoul N. (2019) Perioperative Management of Hyperinsulinism. (springer.com)
Hyperammonemia1
  • PATIENT: Since the neonatal period, a white girl had been treated for hyperammonemia and postprandial hypoglycemia with intermittent hyperinsulinism. (eur.nl)
Pancreas6
  • For children with congenital hyperinsulinism (CHI), low blood sugar is caused by cells in the pancreas that release too much insulin. (clinicaltrials.gov)
  • Children diagnosed with hyperinsulinism who have had partial pancreas removal but still display signs of hyperinsulinism. (clinicaltrials.gov)
  • Congenital hyperinsulinism is characterized by inappropriate and unregulated insulin secretion from the beta-cells of the pancreas. (gosh.nhs.uk)
  • Congenital hyperinsulinism (CHI) is a rare, genetic disease characterised by excessive and unregulated insulin secretion from the β-cells of the pancreas, resulting in persistent and severe hypoglycaemia (low blood glucose) [ 1 , 2 ]. (biomedcentral.com)
  • In case of hyperinsulinism caused by a mosaic, our experience suggests the benefit of a limited resection from the tail to the body of the pancreas. (naver.com)
  • Hyperinsulinism can be caused by diffuse disease affecting the whole pancreas, or by a focal lesion. (uchicago.edu)
Pancreatectomy10
  • A multidisciplinary approach to the focal form of congenital hyperinsulinism leads to successful treatment by partial pancreatectomy. (springer.com)
  • It is worthwhile to identify the minority of severe cases with focal forms of hyperinsulinism because these can be completely cured by partial pancreatectomy. (wikipedia.org)
  • Medication didn't raise them, and when a PET scan indicated Max had diffuse hyperinsulinism (HI) disease, the doctors at the HI Center recommended a pancreatectomy. (chop.edu)
  • Adzick NS, Thornton PS, Stanley CA, Kaye RD, Ruchelli E. A multidisciplinary approach to the focal form of congenital hyperinsulinism leads to successful treatment by partial pancreatectomy. (springer.com)
  • Because congenital hyperinsulinism may be caused either by diffuse involvement of pancreatic β-cells or by a focal cluster of abnormal β-cells, the extent of pancreatectomy varies. (aappublications.org)
  • 2 , 3 , 5 , 6 However, almost 80% of neonates with congenital hyperinsulinism fail to respond to medical treatment and require near-total pancreatectomy. (aappublications.org)
  • Ten had HCM, all of whom required pancreatectomy and eight of whom had confirmed ATP-sensitive potassium-hyperinsulinism. (bmj.com)
  • Glucose metabolism in 105 children and adolescents after pancreatectomy for congenital hyperinsulinism. (naver.com)
  • However, cases of focal hyperinsulinism can be treated effectively with partial pancreatectomy. (elsevier.com)
  • This chapter describes the focal lesions of hyperinsulinism, the pancreatectomy procedure, previous methods of determining the site of focal lesions, and the rationale for using positron emission tomography (PET) scans with 18 F-fluoro-L-DOPA. (elsevier.com)
Pancreatic8
  • Pancreatic venous samplings in infants and children with primary hyperinsulinism. (springer.com)
  • Pancreatic head resection and Roux-en-Y pancreaticojejunostomy for the treatment of the focal form of congenital hyperinsulinism. (springer.com)
  • Pancreatic surgery in infants with Beckwith-Wiedemann syndrome and hyperinsulinism. (springer.com)
  • Acquired hyperinsulinism due to pancreatic insulinoma or ingestion of antidiabetic drugs should be considered with new onset of hyperinsulinism in older children. (renalandurologynews.com)
  • Background: Congenital hyperinsulinism (CHI) is a heterogeneous genetically determined condition that is characterised by unregulated secretion of insulin from pancreatic β-cells. (endocrine-abstracts.org)
  • Congenital hyperinsulinism (CHI) is a heterogeneous disorder leading to increased, often unregulated secretion of insulin from pancreatic beta cells. (biomedcentral.com)
  • Congenital hyperinsulinism (CHI) occurs as a consequence of unregulated insulin secretion from the pancreatic beta-cells. (elsevier.com)
  • Infants with congenital hyperinsulinism may have either focal or diffuse abnormalities of the pancreatic β cells. (elsevier.com)
Transient hyperinsulinism7
  • Transient hyperinsulinism usually results from environmental factors such as maternal diabetes and birth asphyxia. (medscape.com)
  • Infants with perinatal stress (birth asphyxia, intrauterine growth restriction, infant of diabetic mother) can have transient hyperinsulinism lasting for a few days to a few months. (renalandurologynews.com)
  • Transient hyperinsulinism can occur in babies of diabetic mothers who have been exposed to maternal hyperglycaemia before birth. (hyperinsulinismgenes.org)
  • Babies who have sustained perinatal asphyxia and those with intrauterine growth restriction are also at increased risk of transient hyperinsulinism. (hyperinsulinismgenes.org)
  • In a few rare cases transient hyperinsulinism can result from a monogenic aetiology. (hyperinsulinismgenes.org)
  • Neurodevelopmental delays in hyperinsulinism affects both forms: Permanent and transient hyperinsulinism [7]. (heraldopenaccess.us)
  • We present the clinical and biochemical features of an infant with transient hyperinsulinism associated with severe transient primary hyperlactataemia. (heraldopenaccess.us)
Glucose13
  • However, in people with congenital hyperinsulinism, insulin is secreted from beta cells regardless of the amount of glucose present in the blood. (medlineplus.gov)
  • A lack of glucose in the blood results in frequent states of hypoglycemia in people with congenital hyperinsulinism. (medlineplus.gov)
  • Hyperinsulinism can be associated with several types of medical problems, which can be roughly divided into two broad and largely non-overlapping categories: those tending toward reduced sensitivity to insulin and high blood glucose levels (hyperglycemia), and those tending toward excessive insulin secretion and low glucose levels (hypoglycemia). (wikipedia.org)
  • An additional piece of evidence indicating hyperinsulinism is a usually high requirement for intravenous glucose to maintain adequate glucose levels, the minimum glucose required to maintain a plasma glucose above 70 mg/dl. (wikipedia.org)
  • A third form of evidence suggesting hyperinsulinism is a rise of the glucose level after injection of glucagon at the time of the low glucose. (wikipedia.org)
  • Treatment of hyperinsulinism is aimed at maintaining plasma glucose levels at greater than 70 mg/dL. (renalandurologynews.com)
  • In the current study, we tested the hypothesis that Ginkgo biloba extract (GBE) prevented hyperinsulinism-induced glucose intolerance in hepatocytes. (herbs.org)
  • Therefore, hyperinsulinism is characterised by the presence of insulin concentrations that are inappropriately high for the concentration of blood glucose. (bmj.com)
  • Short-chain 3-hydroxyacyl-CoA dehydrogenase deficiency associated with hyperinsulinism: a novel glucose-fatty acid cycle? (portlandpress.com)
  • Contribution of total and intact proinsulins to hyperinsulinism in subjects with obesity, impaired glucose tolerance or type 2 diabetes. (thefreedictionary.com)
  • Mutant expression resulted in more depolarized membrane potential and elevated insulin secretion at basal glucose concentration (3 mM) compared with cells expressing wild type channels, demonstrating that the inactivation gating defect itself is sufficient to cause loss of channel function and hyperinsulinism. (elsevier.com)
  • Congenital hyperinsulinism is a very dangerous disease, which usually occurs in infants and is often confused with epilepsy due to the convulsions caused by Hypoglycemia or low blood glucose levels. (diabetesuptodate.com)
  • Diagnoses of hyperinsulinism and diabetes Type 2 were made with three hour insulin and glucose profiles during initial evaluation at the Institute (see Table below). (aliscience.org)
Clinical8
  • Clinical features of hyperinsulinism may include large for gestational age (LGA) birth weight, small for gestational age (SGA) birth weight, and perinatal stress (maternal toxemia, birth asphyxia, infant of diabetic mother). (renalandurologynews.com)
  • The Hyperinsulinism centre at Great Ormond Street Hospital has a specialist multi-disciplinary team of clinicians, surgeons, nurse specialists, clinical psychologist, researchers, dietician, speech and language therapist, social work and service coordinator. (gosh.nhs.uk)
  • This patient presented the usual clinical picture associated with hyperinsulinism. (annals.org)
  • Dr. Paul Thornton, Director of the Hyperinsulinism Center at Cook Children's Medical Center and one of the world's leaders in HI research and clinical work, spoke about the importance of raising awareness of the condition emphasizing the importance of early diagnosis. (congenitalhi.org)
  • Congenital hyperinsulinism is a rare condition, and following recent advances in diagnosis and treatment, it was considered necessary to formulate evidence-based clinical practice guidelines reflecting the most recent progress, to guide the practice of neonatologists, pediatric endocrinologists, general pediatricians, and pediatric surgeons. (elsevier.com)
  • To use the team's expert understanding of HI genomics and pathophysiology to develop novel therapies for different forms of HI and be a global leader in hyperinsulinism clinical trials. (chop.edu)
  • The Advancement of Hyperinsulinism Care and Research program established a carefully phenotyped and genotyped patient cohort of thousands of individuals with congenital hyperinsulinism that supports research investigations describing novel molecular mechanisms of disease, clinical presentation and natural history of different HI subtypes, and patient outcomes. (chop.edu)
  • I proposed my Oxygen Model of Insulin Toxicity as a unifying model that recognizes disturbances of oxygen functions as the fundamental commonality of all elements that cause dysfunctional insulin signaling, hyperinsulinism (excess insulin), insulin resistance (inability of the insulin receptor to respond to insulin), and the biochemical and clinical consequences of insulin dysfunction. (aliscience.org)
Glutamate1
  • Mechanism of hyperinsulinism in short-chain 3-hydroxyacyl-CoA dehydrogenase deficiency involves activation of glutamate dehydrogenase. (thefreedictionary.com)
Treatment of congenital hyperinsulinism3
  • Adzick NS, DeLeon DD, States LJ, Lord K, Bhatti TA, Becker SA, Stanley CA. Surgical treatment of Congenital Hyperinsulinism: Results from 500 pancreatectomies in neonates and children. (springer.com)
  • Actively involved in the treatment of congenital hyperinsulinism at the international level, Dr. Thornton and our specialty medical team work with other renowned physicians, researchers and specialists to continually improve the care and treatment of children with HI. (cookchildrens.org)
  • The studies proposed here are important to further the development of exendin-(9-39) for the treatment of congenital hyperinsulinism by providing measurements of effect, safety and PK/PD profile of this peptide. (grantome.com)
20172
  • BERKELEY, Calif., Jan. 31, 2017 (GLOBE NEWSWIRE) -- XOMA Corporation (Nasdaq:XOMA), a leader in the discovery and development of therapeutic antibodies, announced today that it has established proof-of-concept for its product candidate 358 in congenital hyperinsulinism (CHI) and hypoglycemia post-bariatric surgery (PBS). (xoma.com)
  • 2017. https://nursing.unboundmedicine.com/nursingcentral/view/Tabers-Dictionary/733435/all/hyperinsulinism. (unboundmedicine.com)
Cause of persistent hypoglycemia3
  • Congenital hyperinsulinism (CHI) is a cause of persistent hypoglycemia. (nih.gov)
  • Congenital hyperinsulinism (HI) is the most frequent cause of persistent hypoglycemia in infants and children. (cdc.gov)
  • Congenital hyperinsulinism is the most common cause of persistent hypoglycemia in infants and it is a major cause of neurological damage with high rates of neurodevelopmental deficits. (heraldopenaccess.us)
Pathophysiology1
  • Despite recent advances in understanding the pathophysiology of hyperinsulinism, the neurological outcome remains poor, and there is often a choice of unsatisfactory treatments, with life long sequelae for the child and his or her family. (bmj.com)
Hypoglycaemia3
  • Background: Children with hypoglycaemia due to Congenital Hyperinsulinism (CHI) usually present in the neonatal period but late presentations also occur. (endocrine-abstracts.org)
  • Congenital hyperinsulinism (CHI) is a rare, genetic disease which causes persistent hypoglycaemia, typically in new-borns. (biomedcentral.com)
  • Dr Bin Sabt told Gulf News that congenital hyperinsulinism is the most frequent cause of severe, persistent hypoglycaemia in newborns and children. (thefreedictionary.com)
Insulin Resistance2
  • Advocates of high-protein diets explain the reason people are fat is not because of the fat they eat, but because of hyperinsulinism and insulin resistance. (drmcdougall.com)
  • Insulin resistance is one of the reasons for hyperinsulinism. (drmcdougall.com)
Fetal1
  • Fetal hyperinsulinism is the likely mediating factor for HCM in HI infants. (bmj.com)
Severe11
  • Milder forms have occasionally been detected by investigation of family members of infants with severe forms, adults with the mildest degrees of congenital hyperinsulinism have a decreased tolerance for prolonged fasting. (wikipedia.org)
  • Erythroblastosis fetalis: Neonates with severe Rh isoimmunization have islet cell hyperplasia and hyperinsulinism. (medscape.com)
  • Discussion HCM appears common in infants with severe hyperinsulinism. (bmj.com)
  • Of the nearly 67,000 patients each year that undergo the Roux-en-Y method of bariatric surgery, approximately five percent will develop severe hypoglycemia. (xoma.com)
  • Clinicians and scientists are working with the Advancement of Hyperinsulinism Care and Research Program to test a new drug that can be used to treat severe forms of HI, in addition to collaborating with industry to test other new therapy options. (chop.edu)
  • Congenital hyperinsulinism is the most frequent cause of severe transient and persistent neonatal hypoglycemia. (endo-ern.eu)
  • Here we report a female newborn, low weight birth and small for gestational age that presented a severe hypoglycemia two hours after birth whose cause was a hyperinsulinism associated a severe hyperlactataemia and where both (hyperinsulinism and hyperlactataemia) were transient. (heraldopenaccess.us)
  • Feeding Problems Are Persistent in Children with Severe Congenital Hyperinsulinism. (cdc.gov)
  • Congenital hyperinsulinism (CHI) is a rare but severe disorder of hypoglycemia in children, often complicated by brain injury. (cdc.gov)
  • Severe hyperinsulinism, rather than nasogastric tube feeding or medications, is the main factor associated with FPs. (cdc.gov)
  • Congenital hyperinsulinism is clinically characterized by an inappropriate insulin secretion resulting in recurrent severe hypoglycemia. (uclouvain.be)
Syndrome2
  • We present a woman with hyperinsulinism/hyperammonaemia (HI/HA) syndrome. (eur.nl)
  • Other diseases of connection to Ashkenazi Jews are Familial Hyperinsulinism , Joubert Syndrome Type 2, Lipoamide Dehydrogenase Deficiency (E3), Nemaline Myopathy, Spinal Muscular Atrophy (SMA), Usher Syndrome Type 3, Usher Syndrom Type I, and Walker Warburg Syndrome. (thefreedictionary.com)
Deficiency1
  • Hyperinsulinism Due to Hnf1a Deficiency, is also known as hyperinsulinemic hypoglycemia due to hnf1a deficiency . (malacards.org)
Diabetes5
  • Acute hyperinsulinism raises plasma interleukin-6 in both non diabetic and type 2 diabetes mellitus subjects, and this effect is inversely associated with body mass index. (thefreedictionary.com)
  • Sian's research focuses on understanding the underlying genetic mechanisms of monogenic endocrine disorders including congenital hyperinsulinism and neonatal diabetes. (hyperinsulinismgenes.org)
  • Ana is part of the monogenic diabetes team assisting in the genetic testing service for Maturity onset Diabetes of the Young (MODY) and congenital hyperinsulinism. (hyperinsulinismgenes.org)
  • Recognizing the need for a systematic approach to care underscored by sound research evidence, CHOP founded the Congenital Hyperinsulinism Center within the Division of Endocrinology and Diabetes in 1998. (chop.edu)
  • Control of hyperinsulinism and reversal of diabetes was achieved in four years (data presented in the table below. (aliscience.org)
Diagnostic4
  • In terms of the investigation of congenital hyperinsulinism, valuable diagnostic information is obtained from a blood sample drawn during hypoglycemia, detectable amounts of insulin during hypoglycemia are abnormal and indicate that hyperinsulinism is likely to be the cause. (wikipedia.org)
  • Once the evidence indicates hyperinsulinism, the diagnostic efforts shift to determining the type. (chemeurope.com)
  • 8 mg/kg per min is virtually diagnostic of hyperinsulinism. (hyperinsulinismgenes.org)
  • These guidelines cover a range of aspects, including general features of congenital hyperinsulinism, diagnostic criteria and tools for diagnosis, first- and second-line medical treatment, criteria for and details of surgical treatment, and future perspectives. (elsevier.com)
Form of Hyperinsulinism2
  • To replace Sandostatine® in three daily subcutaneous injections by a single intramuscular injection of Sandostatine® LP per month in patients with a diffuse form of hyperinsulinism. (clinicaltrials.gov)
  • In this study, researchers affiliated with the University of Pennsylvania will test how well a radioactive drug (called F-DOPA) can detect a form of hyperinsulinism that may be cured by surgery. (clinicaltrials.gov)
Types of hyperinsulinism2
  • However, that was only a temporary fix, so Colton, his mother and twin brother were transported Jan. 31 by air ambulance to the Congenital Hyperinsulinism Center at the Children's Hospital in Philadelphia, one of the few places worldwide that specialize in identifying various types of hyperinsulinism and performing corrective surgery. (tbo.com)
  • There are two types of hyperinsulinism: focal and diffuse. (chop.edu)
Diagnosis of hyperinsulinism3
  • 4-6 mg/kg/min in older infants) strongly suggests a diagnosis of hyperinsulinism over other etiologies of hypoglycemia. (renalandurologynews.com)
  • The diagnosis of hyperinsulinism is best made by a provocative fasting test to elicit the development of hypoglycemia. (renalandurologynews.com)
  • Efforts to improve the neurological outcome need to focus on the initial management in the first days of life, even before the diagnosis of hyperinsulinism. (endo-ern.eu)
Neonates with hyperinsulinism1
  • HCM has been reported in a few neonates with hyperinsulinism, but its extent and risk factors for its development have not been evaluated. (bmj.com)
Hyperinsulinemia or Hyperinsulinism1
  • Hyperinsulinemia or Hyperinsulinism is a condition that refers to high blood insulin levels. (diabetesuptodate.com)
Familial1
  • Familial focal congenital hyperinsulinism. (nih.gov)
Infants with congenital2
  • Palladino AA, Stanley CA. A specialized team approach to diagnosis and medical versus surgical treatment of infants with congenital hyperinsulinism. (springer.com)
  • Infants with congenital hyperinsulinism have excessive prenatal and postnatal insulin secretion due to defects in pathways of insulin secretion (most commonly the K ATP channel). (bmj.com)
Diffuse form1
  • Surgery does not cure the diffuse form of congenital hyperinsulinism but can help prevent hypoglycemia and brain damage. (springer.com)
Hyperinsulinemic2
  • Sandostatine® has neither approval for hyperinsulinism, nor in children even though many international publications reported efficacy of treatment by Sandostatine® in hyperinsulinemic children since 1983. (clinicaltrials.gov)
  • OVERVIEW: What every practitioner needs to know about hyperinsulinemic hypoglycemia in neonates and children Are you sure your patient has hyperinsulinism? (renalandurologynews.com)
Treat hyperinsulinism2
  • One of the first programs in the nation, Cook Children's Hyperinsulinism Center uses a specialized team approach to treat hyperinsulinism (HI). (cookchildrens.org)
  • The Advancement of Hyperinsulinism Care and Research program brings together researchers specializing in molecular genetics and biology, metabolomics and cellular functionomics, and pharmacokinetics and drug development - all of whom work collaboratively to better understand how to diagnose and treat hyperinsulinism (HI). (chop.edu)
Persistent hyperinsulinism2
  • Several genetic causes of persistent hyperinsulinism have been identified. (medscape.com)
  • However, children with persistent hyperinsulinism may have a genetic defect that results in inappropriate secretion of insulin. (medscape.com)
Newborns3
  • Congenital hyperinsulinism affects approximately 1 in 50,000 newborns. (medlineplus.gov)
  • Prolonged hyperinsulinism in infants who are SGA and asphyxiated newborns: Infants who are SGA, experience maternal toxemia, or have birth asphyxia are at increased risk for developing hypoglycemia. (medscape.com)
  • Newborns admitted with hyperinsulinism are cared for in our dedicated pod with access to the most current medical technology, a full team of physicians, nurses and specialists who are recognized around the world for their specific expertise in hyperinsulinism. (cookchildrens.org)
Neonate1
KCNJ11 gene: MedlinePlus Genetics
KCNJ11 gene: MedlinePlus Genetics (medlineplus.gov)
Pediatric Hypoglycemia Workup: Approach Considerations, Imaging Studies, Critical Samples
Pediatric Hypoglycemia Workup: Approach Considerations, Imaging Studies, Critical Samples (emedicine.medscape.com)
Hyperinsulinism: Background, Pathophysiology, Epidemiology
Hyperinsulinism: Background, Pathophysiology, Epidemiology (emedicine.medscape.com)
Hyperinsulinism Workup: Laboratory Studies, Imaging Studies, Other Tests
Hyperinsulinism Workup: Laboratory Studies, Imaging Studies, Other Tests (emedicine.medscape.com)
Hyperinsulinism Clinical Presentation: History, Physical, Causes
Hyperinsulinism Clinical Presentation: History, Physical, Causes (emedicine.medscape.com)
Search of: glucose | Congenital Hyperinsulinism - Modify Search - ClinicalTrials.gov
Search of: glucose | Congenital Hyperinsulinism - Modify Search - ClinicalTrials.gov (clinicaltrials.gov)
Endocrinology Conditions Treated
Endocrinology Conditions Treated (cookchildrens.org)
Pediatric Hypoglycemia: Practice Essentials, Etiology, Epidemiology
Pediatric Hypoglycemia: Practice Essentials, Etiology, Epidemiology (emedicine.medscape.com)
Center for Fetal Diagnosis and Treatment Research Research | Children's Hospital of Philadelphia
Center for Fetal Diagnosis and Treatment Research Research | Children's Hospital of Philadelphia (chop.edu)
Diabetes: Have We Got It All Wrong? | Diabetes Care
Diabetes: Have We Got It All Wrong? | Diabetes Care (care.diabetesjournals.org)
Karla F. Leavens, Author at Renal and Urology News
Karla F. Leavens, Author at Renal and Urology News (renalandurologynews.com)
Diffuse Hyperinsulinism: Max's Story | Children's Hospital of Philadelphia
Diffuse Hyperinsulinism: Max's Story | Children's Hospital of Philadelphia (chop.edu)
How it Works - 23andMe AU, DE, FR & EU
How it Works - 23andMe AU, DE, FR & EU (23andme.com)
High Protein Diets - Dr. McDougall
High Protein Diets - Dr. McDougall (drmcdougall.com)
Conditions we treat | Great Ormond Street Hospital
Conditions we treat | Great Ormond Street Hospital (gosh.nhs.uk)
Search Results | Great Ormond Street Hospital
Search Results | Great Ormond Street Hospital (gosh.nhs.uk)
Congenital Hyperinsulinism News and Updates | Children's Hospital of Philadelphia
Congenital Hyperinsulinism News and Updates | Children's Hospital of Philadelphia (chop.edu)
Congenital Hyperinsulinism Center : Patient Stories | The Children's Hospital of Philadelphia
Congenital Hyperinsulinism Center : Patient Stories | The Children's Hospital of Philadelphia (chop.edu)
Hyperinsulinism / Hyperammonemia Syndrome: Natalie's Story | Children's Hospital of Philadelphia
Hyperinsulinism / Hyperammonemia Syndrome: Natalie's Story | Children's Hospital of Philadelphia (chop.edu)
Hyperinsulinism and Turner Syndrome: Aliza's Story | Children's Hospital of Philadelphia
Hyperinsulinism and Turner Syndrome: Aliza's Story | Children's Hospital of Philadelphia (chop.edu)
Congenital Hyperinsulinism Center News and Updates | Children's Hospital of Philadelphia
Congenital Hyperinsulinism Center News and Updates | Children's Hospital of Philadelphia (chop.edu)
Hypoglycaemia News, Research
Hypoglycaemia News, Research (news-medical.net)
Brandon infant receives lifesaving care for hyperinsulinism | tbo.com
Brandon infant receives lifesaving care for hyperinsulinism | tbo.com (tbo.com)
Pioneers in Hyperinsulinism: Yesterday, Today and Tomorrow | Children's Hospital of Philadelphia
Pioneers in Hyperinsulinism: Yesterday, Today and Tomorrow | Children's Hospital of Philadelphia (chop.edu)