Abnormally high BLOOD GLUCOSE level.
Glucose in blood.
Diabetes mellitus induced experimentally by administration of various diabetogenic agents or by PANCREATECTOMY.
A 51-amino acid pancreatic hormone that plays a major role in the regulation of glucose metabolism, directly by suppressing endogenous glucose production (GLYCOGENOLYSIS; GLUCONEOGENESIS) and indirectly by suppressing GLUCAGON secretion and LIPOLYSIS. Native insulin is a globular protein comprised of a zinc-coordinated hexamer. Each insulin monomer containing two chains, A (21 residues) and B (30 residues), linked by two disulfide bonds. Insulin is used as a drug to control insulin-dependent diabetes mellitus (DIABETES MELLITUS, TYPE 1).
A primary source of energy for living organisms. It is naturally occurring and is found in fruits and other parts of plants in its free state. It is used therapeutically in fluid and nutrient replacement.
A subclass of DIABETES MELLITUS that is not INSULIN-responsive or dependent (NIDDM). It is characterized initially by INSULIN RESISTANCE and HYPERINSULINEMIA; and eventually by GLUCOSE INTOLERANCE; HYPERGLYCEMIA; and overt diabetes. Type II diabetes mellitus is no longer considered a disease exclusively found in adults. Patients seldom develop KETOSIS but often exhibit OBESITY.
Substances which lower blood glucose levels.
An antibiotic that is produced by Stretomyces achromogenes. It is used as an antineoplastic agent and to induce diabetes in experimental animals.
A test to determine the ability of an individual to maintain HOMEOSTASIS of BLOOD GLUCOSE. It includes measuring blood glucose levels in a fasting state, and at prescribed intervals before and after oral glucose intake (75 or 100 g) or intravenous infusion (0.5 g/kg).
A heterogeneous group of disorders characterized by HYPERGLYCEMIA and GLUCOSE INTOLERANCE.
A subtype of DIABETES MELLITUS that is characterized by INSULIN deficiency. It is manifested by the sudden onset of severe HYPERGLYCEMIA, rapid progression to DIABETIC KETOACIDOSIS, and DEATH unless treated with insulin. The disease may occur at any age, but is most common in childhood or adolescence.
A syndrome of abnormally low BLOOD GLUCOSE level. Clinical hypoglycemia has diverse etiologies. Severe hypoglycemia eventually lead to glucose deprivation of the CENTRAL NERVOUS SYSTEM resulting in HUNGER; SWEATING; PARESTHESIA; impaired mental function; SEIZURES; COMA; and even DEATH.
Irregular microscopic structures consisting of cords of endocrine cells that are scattered throughout the PANCREAS among the exocrine acini. Each islet is surrounded by connective tissue fibers and penetrated by a network of capillaries. There are four major cell types. The most abundant beta cells (50-80%) secrete INSULIN. Alpha cells (5-20%) secrete GLUCAGON. PP cells (10-35%) secrete PANCREATIC POLYPEPTIDE. Delta cells (~5%) secrete SOMATOSTATIN.
A syndrome with excessively high INSULIN levels in the BLOOD. It may cause HYPOGLYCEMIA. Etiology of hyperinsulinism varies, including hypersecretion of a beta cell tumor (INSULINOMA); autoantibodies against insulin (INSULIN ANTIBODIES); defective insulin receptor (INSULIN RESISTANCE); or overuse of exogenous insulin or HYPOGLYCEMIC AGENTS.
A 29-amino acid pancreatic peptide derived from proglucagon which is also the precursor of intestinal GLUCAGON-LIKE PEPTIDES. Glucagon is secreted by PANCREATIC ALPHA CELLS and plays an important role in regulation of BLOOD GLUCOSE concentration, ketone metabolism, and several other biochemical and physiological processes. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p1511)
Diminished effectiveness of INSULIN in lowering blood sugar levels: requiring the use of 200 units or more of insulin per day to prevent HYPERGLYCEMIA or KETOSIS.
A type of pancreatic cell representing about 50-80% of the islet cells. Beta cells secrete INSULIN.
Minor hemoglobin components of human erythrocytes designated A1a, A1b, and A1c. Hemoglobin A1c is most important since its sugar moiety is glucose covalently bound to the terminal amino acid of the beta chain. Since normal glycohemoglobin concentrations exclude marked blood glucose fluctuations over the preceding three to four weeks, the concentration of glycosylated hemoglobin A is a more reliable index of the blood sugar average over a long period of time.
The time frame after a meal or FOOD INTAKE.
Abstaining from all food.
Conditions or pathological processes associated with the disease of diabetes mellitus. Due to the impaired control of BLOOD GLUCOSE level in diabetic patients, pathological processes develop in numerous tissues and organs including the EYE, the KIDNEY, the BLOOD VESSELS, and the NERVE TISSUE.
Maintenance of a constant blood glucose level by perfusion or infusion with glucose or insulin. It is used for the study of metabolic rates (e.g., in glucose, lipid, amino acid metabolism) at constant glucose concentration.
The appearance of an abnormally large amount of GLUCOSE in the urine, such as more than 500 mg/day in adults. It can be due to HYPERGLYCEMIA or genetic defects in renal reabsorption (RENAL GLYCOSURIA).
Biosynthesis of GLUCOSE from nonhexose or non-carbohydrate precursors, such as LACTATE; PYRUVATE; ALANINE; and GLYCEROL.
A group of enzymes that catalyzes the conversion of ATP and D-glucose to ADP and D-glucose 6-phosphate. They are found in invertebrates and microorganisms, and are highly specific for glucose. (Enzyme Nomenclature, 1992) EC
The middle segment of proinsulin that is between the N-terminal B-chain and the C-terminal A-chain. It is a pancreatic peptide of about 31 residues, depending on the species. Upon proteolytic cleavage of proinsulin, equimolar INSULIN and C-peptide are released. C-peptide immunoassay has been used to assess pancreatic beta cell function in diabetic patients with circulating insulin antibodies or exogenous insulin. Half-life of C-peptide is 30 min, almost 8 times that of insulin.
A pathological state in which BLOOD GLUCOSE level is less than approximately 140 mg/100 ml of PLASMA at fasting, and above approximately 200 mg/100 ml plasma at 30-, 60-, or 90-minute during a GLUCOSE TOLERANCE TEST. This condition is seen frequently in DIABETES MELLITUS, but also occurs with other diseases and MALNUTRITION.
A serious complication of TYPE 2 DIABETES MELLITUS. It is characterized by extreme HYPERGLYCEMIA; DEHYDRATION; serum hyperosmolarity; and depressed consciousness leading to COMA in the absence of KETOSIS and ACIDOSIS.
KIDNEY injuries associated with diabetes mellitus and affecting KIDNEY GLOMERULUS; ARTERIOLES; KIDNEY TUBULES; and the interstitium. Clinical signs include persistent PROTEINURIA, from microalbuminuria progressing to ALBUMINURIA of greater than 300 mg/24 h, leading to reduced GLOMERULAR FILTRATION RATE and END-STAGE RENAL DISEASE.
A life-threatening complication of diabetes mellitus, primarily of TYPE 1 DIABETES MELLITUS with severe INSULIN deficiency and extreme HYPERGLYCEMIA. It is characterized by KETOSIS; DEHYDRATION; and depressed consciousness leading to COMA.
The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.
A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.
Two populations of Zucker rats have been cited in research--the "fatty" or obese and the lean. The "fatty" rat (Rattus norvegicus) appeared as a spontaneous mutant. The obese condition appears to be due to a single recessive gene.
A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.
The state of PREGNANCY in women with DIABETES MELLITUS. This does not include either symptomatic diabetes or GLUCOSE INTOLERANCE induced by pregnancy (DIABETES, GESTATIONAL) which resolves at the end of pregnancy.
Elements of limited time intervals, contributing to particular results or situations.
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain.
A disturbance in the prooxidant-antioxidant balance in favor of the former, leading to potential damage. Indicators of oxidative stress include damaged DNA bases, protein oxidation products, and lipid peroxidation products (Sies, Oxidative Stress, 1991, pxv-xvi).
A status with BODY WEIGHT that is grossly above the acceptable or desirable weight, usually due to accumulation of excess FATS in the body. The standards may vary with age, sex, genetic or cultural background. In the BODY MASS INDEX, a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese (MORBID OBESITY).
A nodular organ in the ABDOMEN that contains a mixture of ENDOCRINE GLANDS and EXOCRINE GLANDS. The small endocrine portion consists of the ISLETS OF LANGERHANS secreting a number of hormones into the blood stream. The large exocrine portion (EXOCRINE PANCREAS) is a compound acinar gland that secretes several digestive enzymes into the pancreatic ductal system that empties into the DUODENUM.
An autosomal recessive metabolic disorder caused by deficiencies in the mitochondrial GLYCINE cleavage system.
A peptide of 36 or 37 amino acids that is derived from PROGLUCAGON and mainly produced by the INTESTINAL L CELLS. GLP-1(1-37 or 1-36) is further N-terminally truncated resulting in GLP-1(7-37) or GLP-1-(7-36) which can be amidated. These GLP-1 peptides are known to enhance glucose-dependent INSULIN release, suppress GLUCAGON release and gastric emptying, lower BLOOD GLUCOSE, and reduce food intake.
Involuntary, forcible, rapid, jerky movements that may be subtle or become confluent, markedly altering normal patterns of movement. Hypotonia and pendular reflexes are often associated. Conditions which feature recurrent or persistent episodes of chorea as a primary manifestation of disease are referred to as CHOREATIC DISORDERS. Chorea is also a frequent manifestation of BASAL GANGLIA DISEASES.
Products derived from the nonenzymatic reaction of GLUCOSE and PROTEINS in vivo that exhibit a yellow-brown pigmentation and an ability to participate in protein-protein cross-linking. These substances are involved in biological processes relating to protein turnover and it is believed that their excessive accumulation contributes to the chronic complications of DIABETES MELLITUS.
The time period before the development of symptomatic diabetes. For example, certain risk factors can be observed in subjects who subsequently develop INSULIN RESISTANCE as in type 2 diabetes (DIABETES MELLITUS, TYPE 2).
Disease of the RETINA as a complication of DIABETES MELLITUS. It is characterized by the progressive microvascular complications, such as ANEURYSM, interretinal EDEMA, and intraocular PATHOLOGIC NEOVASCULARIZATION.
FATTY ACIDS found in the plasma that are complexed with SERUM ALBUMIN for transport. These fatty acids are not in glycerol ester form.
Peripheral, autonomic, and cranial nerve disorders that are associated with DIABETES MELLITUS. These conditions usually result from diabetic microvascular injury involving small blood vessels that supply nerves (VASA NERVORUM). Relatively common conditions which may be associated with diabetic neuropathy include third nerve palsy (see OCULOMOTOR NERVE DISEASES); MONONEUROPATHY; mononeuropathy multiplex; diabetic amyotrophy; a painful POLYNEUROPATHY; autonomic neuropathy; and thoracoabdominal neuropathy. (From Adams et al., Principles of Neurology, 6th ed, p1325)
A disease or state in which death is possible or imminent.
The transference of pancreatic islets within an individual, between individuals of the same species, or between individuals of different species.
An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.
An amino sugar formed when glucose non-enzymatically reacts with the N-terminal amino group of proteins. The fructose moiety is derived from glucose by the "classical" Amadori rearrangement.
Disease having a short and relatively severe course.
Mutant mice exhibiting a marked obesity coupled with overeating, hyperglycemia, hyperinsulinemia, marked insulin resistance, and infertility when in a homozygous state. They may be inbred or hybrid.
The range or frequency distribution of a measurement in a population (of organisms, organs or things) that has not been selected for the presence of disease or abnormality.
A glucose transport facilitator that is expressed primarily in PANCREATIC BETA CELLS; LIVER; and KIDNEYS. It may function as a GLUCOSE sensor to regulate INSULIN release and glucose HOMEOSTASIS.
An inhibitor of ALPHA-GLUCOSIDASES that retards the digestion and absorption of DIETARY CARBOHYDRATES in the SMALL INTESTINE.
The release of GLUCOSE from GLYCOGEN by GLYCOGEN PHOSPHORYLASE (phosphorolysis). The released glucose-1-phosphate is then converted to GLUCOSE-6-PHOSPHATE by PHOSPHOGLUCOMUTASE before entering GLYCOLYSIS. Glycogenolysis is stimulated by GLUCAGON or EPINEPHRINE via the activation of PHOSPHORYLASE KINASE.
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
Conditions with excess LIPIDS in the blood.
The long-term (minutes to hours) administration of a fluid into the vein through venipuncture, either by letting the fluid flow by gravity or by pumping it.
Single pavement layer of cells which line the luminal surface of the entire vascular system and regulate the transport of macromolecules and blood components.
Diabetes mellitus induced by PREGNANCY but resolved at the end of pregnancy. It does not include previously diagnosed diabetics who become pregnant (PREGNANCY IN DIABETICS). Gestational diabetes usually develops in late pregnancy when insulin antagonistic hormones peaks leading to INSULIN RESISTANCE; GLUCOSE INTOLERANCE; and HYPERGLYCEMIA.
An enzyme that catalyzes the conversion of D-glucose 6-phosphate and water to D-glucose and orthophosphate. EC
The relationship between the dose of an administered drug and the response of the organism to the drug.
Glycogen stored in the liver. (Dorland, 28th ed)
The processes whereby the internal environment of an organism tends to remain balanced and stable.
2-Deoxy-D-arabino-hexose. An antimetabolite of glucose with antiviral activity.
An enzyme that catalyzes reversibly the oxidation of an aldose to an alditol. It possesses broad specificity for many aldoses. EC
A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289)
A state of unconsciousness as a complication of diabetes mellitus. It occurs in cases of extreme HYPERGLYCEMIA or extreme HYPOGLYCEMIA as a complication of INSULIN therapy.
A pancreatic polypeptide of about 110 amino acids, depending on the species, that is the precursor of insulin. Proinsulin, produced by the PANCREATIC BETA CELLS, is comprised sequentially of the N-terminal B-chain, the proteolytically removable connecting C-peptide, and the C-terminal A-chain. It also contains three disulfide bonds, two between A-chain and B-chain. After cleavage at two locations, insulin and C-peptide are the secreted products. Intact proinsulin with low bioactivity also is secreted in small amounts.
A sodium-glucose transporter that is expressed in the luminal membrane of the PROXIMAL KIDNEY TUBULES.
A type of pancreatic cell representing about 5-20% of the islet cells. Alpha cells secrete GLUCAGON.
A 14-amino acid peptide named for its ability to inhibit pituitary GROWTH HORMONE release, also called somatotropin release-inhibiting factor. It is expressed in the central and peripheral nervous systems, the gut, and other organs. SRIF can also inhibit the release of THYROID-STIMULATING HORMONE; PROLACTIN; INSULIN; and GLUCAGON besides acting as a neurotransmitter and neuromodulator. In a number of species including humans, there is an additional form of somatostatin, SRIF-28 with a 14-amino acid extension at the N-terminal.
Portable or implantable devices for infusion of insulin. Includes open-loop systems which may be patient-operated or controlled by a pre-set program and are designed for constant delivery of small quantities of insulin, increased during food ingestion, and closed-loop systems which deliver quantities of insulin automatically based on an electronic glucose sensor.
A cluster of metabolic risk factors for CARDIOVASCULAR DISEASES and TYPE 2 DIABETES MELLITUS. The major components of metabolic syndrome X include excess ABDOMINAL FAT; atherogenic DYSLIPIDEMIA; HYPERTENSION; HYPERGLYCEMIA; INSULIN RESISTANCE; a proinflammatory state; and a prothrombotic (THROMBOSIS) state. (from AHA/NHLBI/ADA Conference Proceedings, Circulation 2004; 109:551-556)
A polyhydric alcohol with about half the sweetness of sucrose. Sorbitol occurs naturally and is also produced synthetically from glucose. It was formerly used as a diuretic and may still be used as a laxative and in irrigating solutions for some surgical procedures. It is also used in many manufacturing processes, as a pharmaceutical aid, and in several research applications.
Self evaluation of whole blood glucose levels outside the clinical laboratory. A digital or battery-operated reflectance meter may be used. It has wide application in controlling unstable insulin-dependent diabetes.
Cell surface receptors that bind glucagon with high affinity and trigger intracellular changes which influence the behavior of cells. Activation of glucagon receptors causes a variety of effects; the best understood is the initiation of a complex enzymatic cascade in the liver which ultimately increases the availability of glucose to body organs.
Salts or esters of LACTIC ACID containing the general formula CH3CHOHCOOR.

Accelerated intimal hyperplasia and increased endogenous inhibitors for NO synthesis in rabbits with alloxan-induced hyperglycaemia. (1/3915)

1. We examined whether endogenous inhibitors of NO synthesis are involved in the augmentation of intimal hyperplasia in rabbits with hyperglycaemia induced by alloxan. 2. Four weeks after the endothelial denudation of carotid artery which had been performed 12 weeks after alloxan, the intimal hyperplasia was greatly augmented with hyperglycaemia. The degree of hyperplasia was assessed using three different parameters of histopathological findings as well as changes in luminal area and intima: media ratio. 3. There were positive and significant correlations between intima:media ratio, plasma glucose, and concentrations of N(G)-monomethyl-L-arginine (L-NMMA) and N(G), N(G)-dimethyl-L-arginine (ADMA) in endothelial cells, that is, the intima:media ratio became greater as plasma glucose and endothelial L-NMMA and ADMA were increased. Furthermore, endothelial L-NMMA and ADMA were increased in proportion to the increase in plasma glucose. 4. In contrast, there were inverse and significant correlations between cyclic GMP production by carotid artery strips with endothelium and plasma glucose, between cyclic GMP production and endothelial L-NMMA and ADMA, and between the intima:media ratio and cyclic GMP production. 5. Exogenously applied L-NMMA and ADMA inhibited cyclic GMP production in a concentration-dependent manner. IC50 values were determined to be 12.1 microM for the former and 26.2 microM for the latter. The cyclic GMP production was abolished after the deliberate removal of endothelium from the artery strips. 6. These results suggest that the augmentation of intimal hyperplasia with hyperglycaemia is closely related to increased accumulation of L-NMMA and ADMA with hyperglycaemia, which would result in an accelerated reduction in NO production/release by endothelial cells.  (+info)

Effect of hyperglycemia-hyperinsulinemia on whole body and regional fatty acid metabolism. (2/3915)

The effects of combined hyperglycemia-hyperinsulinemia on whole body, splanchnic, and leg fatty acid metabolism were determined in five volunteers. Catheters were placed in a femoral artery and vein and a hepatic vein. U-13C-labeled fatty acids were infused, once in the basal state and, on a different occasion, during infusion of dextrose (clamp; arterial glucose 8.8 +/- 0.5 mmol/l). Lipids and heparin were infused together with the dextrose to maintain plasma fatty acid concentrations at basal levels. Fatty acid availability in plasma and fatty acid uptake across the splanchnic region and the leg were similar during the basal and clamp experiments. Dextrose infusion decreased fatty acid oxidation by 51.8% (whole body), 47.4% (splanchnic), and 64.3% (leg). Similarly, the percent fatty acid uptake oxidized decreased at the whole body level (53 to 29%), across the splanchnic region (30 to 13%), and in the leg (48 to 22%) during the clamp. We conclude that, in healthy men, combined hyperglycemia-hyperinsulinemia inhibits fatty acid oxidation to a similar extent at the whole body level, across the leg, and across the splanchnic region, even when fatty acid availability is constant.  (+info)

Effects of duodenal distension on antropyloroduodenal pressures and perception are modified by hyperglycemia. (3/3915)

Marked hyperglycemia (blood glucose approximately 15 mmol/l) affects gastrointestinal motor function and modulates the perception of gastrointestinal sensations. The aims of this study were to evaluate the effects of mild hyperglycemia on the perception of, and motor responses to, duodenal distension. Paired studies were done in nine healthy volunteers, during euglycemia ( approximately 4 mmol/l) and mild hyperglycemia ( approximately 10 mmol/l), in randomized order, using a crossover design. Antropyloroduodenal pressures were recorded with a manometric, sleeve-side hole assembly, and proximal duodenal distensions were performed with a flaccid bag. Intrabag volumes were increased at 4-ml increments from 12 to 48 ml, each distension lasting for 2.5 min and separated by 10 min. Perception of the distensions and sensations of fullness, nausea, and hunger were evaluated. Perceptions of distension (P < 0.001) and fullness (P < 0.05) were greater and hunger less (P < 0.001) during hyperglycemia compared with euglycemia. Proximal duodenal distension stimulated pyloric tone (P < 0.01), isolated pyloric pressure waves (P < 0.01), and duodenal pressure waves (P < 0.01). Compared with euglycemia, hyperglycemia was associated with increases in pyloric tone (P < 0.001), the frequency (P < 0.05) and amplitude (P < 0.01) of isolated pyloric pressure waves, and the frequency of duodenal pressure waves (P < 0.001) in response to duodenal distension. Duodenal compliance was less (P < 0.05) during hyperglycemia compared with euglycemia, but this did not account for the effects of hyperglycemia on perception. We conclude that both the perception of, and stimulation of pyloric and duodenal pressures by, duodenal distension are increased by mild hyperglycemia. These observations are consistent with the concept that the blood glucose concentration plays a role in the regulation of gastrointestinal motility and sensation.  (+info)

Time-dependent and tissue-specific effects of circulating glucose on fetal ovine glucose transporters. (4/3915)

To determine the cellular adaptations to fetal hyperglycemia and hypoglycemia, we examined the time-dependent effects on basal (GLUT-1 and GLUT-3) and insulin-responsive (GLUT-4) glucose transporter proteins by quantitative Western blot analysis in fetal ovine insulin-insensitive (brain and liver) and insulin-sensitive (myocardium, skeletal muscle, and adipose) tissues. Maternal glucose infusions causing fetal hyperglycemia resulted in a transient 30% increase in brain GLUT-1 but not GLUT-3 levels and a decline in liver and adipose GLUT-1 and myocardial and skeletal muscle GLUT-1 and GLUT-4 levels compared with gestational age-matched controls. Maternal insulin infusions leading to fetal hypoglycemia caused a decline in brain GLUT-3, an increase in brain GLUT-1, and a subsequent decline in liver GLUT-1, with no significant change in insulin-sensitive myocardium, skeletal muscle, and adipose tissue GLUT-1 or GLUT-4 concentrations, compared with gestational age-matched sham controls. We conclude that fetal glucose transporters are subject to a time-dependent and tissue- and isoform-specific differential regulation in response to altered circulating glucose and/or insulin concentrations. These cellular adaptations in GLUT-1 (and GLUT-3) are geared toward protecting the conceptus from perturbations in substrate availability, and the adaptations in GLUT-4 are geared toward development of fetal insulin resistance.  (+info)

Brain-derived neurotrophic factor improves blood glucose control and alleviates fasting hyperglycemia in C57BLKS-Lepr(db)/lepr(db) mice. (5/3915)

Systemic administration of brain-derived neurotrophic factor (BDNF) decreases nonfasted blood glucose in obese, non-insulin-dependent diabetic C57BLKS-Lepr(db)/lepr(db) (db/db) mice, with a concomitant decrease in body weight. By measuring percent HbA1c in BDNF-treated and pair-fed animals, we show that the effects of BDNF on nonfasted blood glucose levels are not caused by decreased food intake but reflect a significant improvement in blood glucose control. Furthermore, once established, this effect can persist for weeks after cessation of BDNF treatment. Oral glucose tolerance tests were performed to examine the effects of BDNF on blood glucose control in the fasted state and after an oral glucose challenge. BDNF treatment normalized fasting blood glucose from initially hyperglycemic levels and also showed evidence for beneficial, although less marked, effects on the ability to remove exogenous glucose from blood. One means to lower fasting blood glucose is to reduce the glucose output of peripheral tissues that normally play a part in the maintenance of fasting hyperglycemia. Because the liver is the major endogenous source of glucose in blood during fasting, and because hepatic weight and glucose output are increased in type 2 diabetes, we evaluated the effects of BDNF on liver tissue. BDNF reduced the hepatomegaly present in db/db mice, in association with reduced liver glycogen and reduced liver enzyme activity in serum, supporting the possible involvement of liver tissue in the mechanism of action for BDNF.  (+info)

Hyperglycemia inhibits insulin activation of Akt/protein kinase B but not phosphatidylinositol 3-kinase in rat skeletal muscle. (6/3915)

Sustained hyperglycemia impairs insulin-stimulated glucose utilization in the skeletal muscle of both humans and experimental animals--a phenomenon referred to clinically as glucose toxicity. To study how this occurs, a model was developed in which hyperglycemia produces insulin resistance in vitro. Rat extensor digitorum longus muscles were preincubated for 4 h in Krebs-Henseleit solution containing glucose or glucose + insulin at various concentrations, after which insulin action was studied. Preincubation with 25 mmol/l glucose + insulin (10 mU/ml) led to a 70% decrease in the ability of insulin (10 mU/ml) to stimulate glucose incorporation into glycogen and a 30% decrease in 2-deoxyglucose (2-DG) uptake, compared with muscles incubated with 0 mmol/l glucose. Glucose incorporation into lipid and its oxidation to CO2 were marginally diminished, if at all. The alterations of glycogen synthesis and 2-DG uptake were first evident after 1 h and were maximal after 2 h of preincubation; they were not observed in muscles preincubated with 25 mmol/l glucose + insulin for 5 min. Preincubation for 4 h with 25 mmol/l glucose in the absence of insulin produced a similar although somewhat smaller decrease in insulin-stimulated glycogen synthesis; however, it did not alter 2-DG uptake, glucose oxidation to CO2, or incorporation into lipids. Studies of insulin signaling in the latter muscles revealed that activation of Akt/protein kinase B (PKB) was diminished by 60%, compared with that of muscles preincubated in a glucose-free medium; whereas activation of phosphatidylinositol (PI) 3-kinase, an upstream regulator of Akt/PKB in the insulin-signaling cascade, and of mitogen-activated protein (MAP) kinase, a parallel signal, was unaffected. Immunoblots demonstrated that this was not due to a change in Akt/PKB abundance. The results indicate that hyperglycemia-induced insulin resistance can be studied in rat skeletal muscle in vitro. They suggest that impairment of insulin action in these muscles is related to inhibition of Akt/PKB by events that do not affect PI 3-kinase.  (+info)

Hyperglycemia and focal brain ischemia. (7/3915)

The influence of hyperglycemic ischemia on tissue damage and cerebral blood flow was studied in rats subjected to short-lasting transient middle cerebral artery (MCA) occlusion. Rats were made hyperglycemic by intravenous infusion of glucose to a blood glucose level of about 20 mmol/L, and MCA occlusion was performed with the intraluminar filament technique for 15, 30, or 60 minutes, followed by 7 days of recovery. Normoglycemic animals received saline infusion. Perfusion-fixed brains were examined microscopically, and the volumes of selective neuronal necrosis and infarctions were calculated. Cerebral blood flow was measured autoradiographically at the end of 30 minutes of MCA occlusion and after 1 hour of recirculation in normoglycemic and hyperglycemic animals. In two additional groups with 30 minutes of MCA occlusion, CO2 was added to the inhaled gases to create a similar tissue acidosis as in hyperglycemic animals. In one group CBF was measured, and the second group was examined for tissue damage after 7 days. Fifteen and 30 minutes of MCA occlusion in combination with hyperglycemia produced larger infarcts and smaller amounts of selective neuronal necrosis than in rats with normal blood glucose levels, a significant difference in the total volume of ischemic damage being found after 30 minutes of MCA occlusion. After 60 minutes of occlusion, when the volume of infarction was larger, only minor differences between normoglycemic and hyperglycemic animals were found. Hypercapnic animals showed volumes of both selective neuronal necrosis and infarction that were almost identical with those observed in normoglycemic, normocapnic animals. When local CBF was measured in the ischemic core after 30 minutes of occlusion, neither the hyperglycemic nor the hypercapnic animals were found to be significantly different from the normoglycemic group. Brief focal cerebral ischemia combined with hyperglycemia leads to larger and more severe tissue damage. Our results do not support the hypothesis that the aggravated injury is caused by any disturbances in CBF.  (+info)

Renal changes on hyperglycemia and angiotensin-converting enzyme in type 1 diabetes. (8/3915)

Hyperglycemia causes capillary vasodilation and high glomerular capillary hydraulic pressure, which lead to glomerulosclerosis and hypertension in type 1 diabetic subjects. The insertion/deletion (I/D) polymorphism of the angiotensin I-converting enzyme (ACE) gene can modulate risk of nephropathy due to hyperglycemia, and the II genotype (producing low plasma ACE concentrations and probably reduced renal angiotensin II generation and kinin inactivation) may protect against diabetic nephropathy. We tested the possible interaction between ACE I/D polymorphism and uncontrolled type 1 diabetes by measuring glomerular filtration rate (GFR) and effective renal plasma flow (ERPF) during normoglycemia ( approximately 5 mmol/L) and hyperglycemia ( approximately 15 mmol/L) in 9 normoalbuminuric, normotensive type 1 diabetic subjects with the II genotype and 18 matched controls with the ID or DD genotype. Baseline GFR (145+/-22 mL/min per 1.73 m2) and ERPF (636+/-69 mL/min per 1.73 m2) of II subjects declined by 8+/-10% and 10+/-9%, respectively, during hyperglycemia; whereas baseline GFR (138+/-16 mL/min per 1.73 m2) and ERPF (607+/-93 mL/min per 1.73 m2) increased by 4+/-7% and 6+/-11%, respectively, in ID and DD subjects (II versus ID or DD subjects: P=0.0007 and P=0.0005, for GFR and ERPF, respectively). The changes in renal hemodynamics of subjects carrying 1 or 2 D alleles were compatible, with a mainly preglomerular vasodilation induced by hyperglycemia, proportional to plasma ACE concentration (P=0.024); this was not observed in subjects with the II genotype. Thus, type 1 diabetic individuals with the II genotype are resistant to glomerular changes induced by hyperglycemia, providing a basis for their reduced risk of nephropathy.  (+info)

Background: Admission hyperglycemia is associated with increased morbidity and mortality in trauma patients. However, admission hyperglycemia is not only associated with stress-induced hyperglycemia (SIH) but also with diabetic hyperglycemia (DH); furthermore, patients with normoglycemia may not only have non-diabetic normoglycemia (NDN) but also have a possibility of diabetic normoglycemia (DN), with the diabetes under control. This study aimed to assess the effects of SIH and DH on the mortality outcomes of traumatic femoral fracture patients with NDN and DN. Methods: Admission hyperglycemia was diagnosed as a serum glucose ≥200 mg/dL upon arrival at the emergency department. Diabetes mellitus (DM) was determined by patient history and/or admission HbA1c ≥ 6.5%. DH and SIH were diagnosed by admission hyperglycemia in patients with and without DM. DN and NDN were determined by absence of admission hyperglycemia in patients with and without DM. These patients were allocated into four groups: SIH (n
Background: Admission hyperglycemia is associated with higher morbidity and mortality in patients with traumatic brain injury (TBI). Stress-induced hyperglycemia (SIH), a form of hyperglycemia induced by the stress response, is associated with increased patient mortality following TBI. However, admission hyperglycemia occurs not only in SIH but also in patients with diabetic hyperglycemia (DH). Current information regarding whether trauma patients with SIH represent a distinct group with differential outcomes compared to those with DH remains limited. Methods: Serum glucose concentration ≥200 mg/dL upon arrival at the emergency department was defined as hyperglycemia. Presence of diabetes mellitus (DM) was determined by patient history and/or admission glycated hemoglobin (HbA1c) level ≥6.5%. In the present study, the patient cohort included those with moderate and severe TBI, as defined by an Abbreviated Injury Scale (AIS) score ≥3 points in the head, and excluded those who had additional AIS
Neurovascular coupling (NVC) is the link between neural activity and the corresponding changes to regional cerebral blood flow. Chronic hyperglycemia associated with diabetes has deleterious effects on vascular function. However, the potential effects of acute hyperglycemia on NVC in healthy humans is unknown. We aimed to characterize the effects of acute hyperglycemia on NVC response magnitude in females and males, and hypothesized that acute hyperglycemia would reduce NVC response magnitude. 40 healthy participants (21.6±1.7 yrs; BMI 24.1±4.1 kg/m2; 20 females) were instrumented with electrocardiogram (ECG) to measure heart rate (HR), Finometer to measure mean arterial pressure (MAP), transcranial Doppler ultrasound (TCD) for measurement of posterior cerebral artery velocity (PCAv). Blood glucose was tested using a glucometer and capillary draw via sterile lancet. NVC responses were elicited using a standardized strobe light visual stimulus (VS; 6Hz, 360rpm; 5x30sec on/60sec off) before ...
Fingerprint Dive into the research topics of High-polyphenol chocolate reduces endothelial dysfunction and oxidative stress during acute transient hyperglycaemia in Type 2 diabetes: a pilot randomized controlled trial. Together they form a unique fingerprint. ...
Słowik, A.; Zwolińska, G.; Tomik, B.; Wyrwicz-Petkow, U.; Szczudlik, A., 1998: Prognostic significance of transient hyperglycemia in acute phase of ischemic stroke
OBJECTIVE: We sought to evaluate the effects of acute hyperglycemia induced by intraperitoneal injection of glucose (2.7 g/kg) on vascular delivery to GL261 mouse gliomas kept at moderate hypothermia (~30 °C). MATERIALS AND METHODS: Seven GL261 glioma-bearing mice were studied by T1-weighted DCE MRI before and after an injection of glucose (n = 4) or saline (n = 3). Maximum relative contrast enhancement (RCE) and initial area under the enhancement curve (IAUC) were determined in each pixel. RESULTS: The mean tumor parameter values showed no significant changes after injecting either saline (RCE -5.9 ± 5.0 %; IAUC -3.7 ± 3.6 %) or glucose (RCE -1.6 ± 9.0 %; IAUC +0.6 ± 6.4 %). Pixel-by-pixel analysis revealed small post-injection changes in RCE and IAUC between the glucose and saline groups, all within 13 % range of their baseline values. CONCLUSION: Perturbing the metabolism of GL261 tumors kept at moderate hypothermia with hyperglycemia did not induce significant changes in the permeability
Scarlett Law Group injury blog - Hyperglycemia can indicate traumatic brain injury. Contact a San Francisco Catastrophic Injury Lawyer today!
Hyperglycemia is associated with increased morbidity and mortality in hospitalized patients with a variety of medical conditions [1-3]. However, while the association between glucose concentration in hospital and mortality is strong in patients without known diabetes, paradoxically glucose concentration is not as strongly associated with mortality in patients with diabetes [2-6]. This suggests that background glycemia influences the relationship between glucose and mortality in patients admitted to hospital.. An elevated blood glucose in a hospitalized patient can occur because a patient has poor chronic glycemic control or if there is an acute increase in glucose, often termed stress hyperglycemia [7]. Stress hyperglycemia is the relative increase in glucose in response to an intercurrent illness. Our group has recently proposed a novel metric for relative glycemia termed the stress hyperglycemia ratio (SHR), whereby admission glucose concentration is corrected for background glycemia estimated ...
Hyperglycemia and insulin resistance are common among critically ill patients and occur in patients with or without a history of diabetes mellitus. All patients undergoing critical illness are at risk for stress-induced hyperglycemia. Some patients may be at greater risk for hyperglycemia than others when considering underlying disease states and iatrogenic factors. Many recent studies demonstrate that tight glucose control can decrease morbidity and mortality associated with critical illness. This article reviews the pathophysiology behind stress-induced hyperglycemia, the evidence to support tight glycemic control, and the importance of an intensive insulin therapy protocol to standardize treatment among critical care patients. ...
Our study indicates that perioperative hyperglycemia is associated with increased risk of hospital complications in patients undergoing noncardiac surgery. Perioperative hyperglycemia significantly increased the risk of pneumonia, systemic blood infections, urinary tract infection, skin infections, and ARF during the postoperative period. In addition, we found a significant association between blood glucose concentration and mortality; however, the impact of hyperglycemia on mortality rate was more significant among patients without a history of diabetes compared with those with known diabetes before admission.. The association between hyperglycemia and increased risk of hospital complications and mortality in critically ill (1,8,12,13) patients undergoing major cardiovascular surgery (12,16,17) is well established. Less information is available on the significance of hyperglycemia in those undergoing general and noncardiac surgery. Small observational studies in noncardiac surgery patients have ...
Repeated mental stress may lead to chronic alterations in cortisol and catecholamine concentrations and to insulin resistance. Furthermore, chronically elevated cortisol concentrations may favour the development of abdominal obesity and of the metabolic syndrome. Oxidative stress impairs glucose uptake in muscle and fat and correlates with BMI. Obese subjects with type 2 diabetes, especially soon after the onset of diabetes, usually exhibit postprandial hyperglycemia with delayed hyperinsulinemia. It is recognized that insulin resistance causes postprandial hyperglycemia ; however, it is also possible that impairment of early insulin secretion in response to an oral glucose load is the reason why postprandial hyperglycemia occurs. Since even modest increases in postprandial glucose values can be a risk factor for cardiovascular disease. Therefore, the effects of palatinose based functional food which reduces postprandial hyperglycemia and hyperinsulinemia were investigated in rats. This novel ...
TY - JOUR. T1 - Relationship between vitamin D deficiency, post-challenge hyperglycemia, and endothelial function in healthy older adults. AU - Sokol, Seth I.. AU - Grushko, Michael. AU - Srinivas, Vankeepuram S.. AU - Crandall, Jill P.. PY - 2012/3/1. Y1 - 2012/3/1. KW - Endothelial function. KW - Glucose intolerance. KW - Vitamin D. UR - http://www.scopus.com/inward/record.url?scp=84857423787&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=84857423787&partnerID=8YFLogxK. U2 - 10.1111/j.1753-0407.2011.00158.x. DO - 10.1111/j.1753-0407.2011.00158.x. M3 - Letter. C2 - 21936883. AN - SCOPUS:84857423787. VL - 4. SP - 102. EP - 103. JO - Journal of Diabetes. JF - Journal of Diabetes. SN - 1753-0393. IS - 1. ER - ...
Perioperative hyperglycemia is associated with postoperative neurocognitive disorders after cardiac surgery Xiaopeng Zhang,1 Xiaowei Yan,2 Jennifer Gorman,2 Stuart N Hoffman,3 Li Zhang,1 Joseph A Boscarino2 1Department of Anesthesiology, Geisinger Medical Center, 2Center for Health Research, Geisinger Clinic, 3Department of Neurology, Geisinger Medical Center, Danville, PA, USA Objective: Neurocognitive disorders commonly occur following cardiac surgery. However, the underlying etiology of these disorders is not well understood. The current study examined the association between perioperative glucose levels and other risk factors and the onset of neurocognitive disorders in adult patients following coronary artery bypass and/or valvular surgery. Methods: Adult patients who underwent their first cardiac surgery at a large tertiary care medical center were identified and those with neurocognitive disorders prior to surgery were excluded. Demographic, perioperative, and postoperative neurocognitive
Chronic hyperglycemia contributes to beta-cell dysfunction in diabetes and with islet transplantation, but the mechanisms remain unclear. Recent studies demonstrate that the unfolded protein response (UPR) is critical for beta-cell function. Here, we assessed the influence of hyperglycemia on UPR gene expression in transplanted islets. Streptozotocin-induced diabetic or control nondiabetic mice were transplanted under the kidney capsule with syngeneic islets either sufficient or not to normalize hyperglycemia. Twenty-one days after transplantation, islet grafts were excised and RT-PCR was used to assess gene expression. In islet grafts from diabetic mice, expression levels of many UPR genes of the IRE1/ATF6 pathways, which are important for adaptation to endoplasmic reticulum stress, were markedly reduced compared with that in islet grafts from control mice. UPR genes of the PERK pathway were also downregulated. The normalization of glycemia restored the changes in mRNA expression, suggesting that
Stress hyperglycemia (also called stress diabetes or diabetes of injury) is a medical term referring to transient elevation of the blood glucose due to the stress of illness. It usually resolves spontaneously, but must be distinguished from various forms of diabetes mellitus. It is often discovered when routine blood chemistry measurements in an ill patient reveal an elevated blood glucose. Blood glucose can be assessed either by a bedside fingerstick glucose meter or plasma glucose as performed in a laboratory (the latter being more efficacious). A retrospective cohort study by the Mayo Clinic held that bedside glucometry was a reliable estimate of plasma glucose with a mean difference of 7.9 mg/dL, but still may not coincide with every individual. The glucose is typically in the range of 140-300 mg/dl (7.8-16.7 mM) but occasionally can exceed 500 mg/dl (28 mM), especially if amplified by drugs or intravenous glucose. The blood glucose usually returns to normal within hours unless ...
One of the most common causes is stress hyperglycemia.In a stressful situation, the body needs energy source.The adrenal glands are released into the blood hormones cortisol and adrenaline, which cause liver glycogen conversion to glucose.As a result, the blood sugar level increases dramatically, allowing the flow of energy.Therefore, even a common fear of taking a blood test can lead to incorrect results.The same situation occurs when emotional experiences, trauma, surgery, physical exercise.. Quite often diagnosed hyperglycemia and infectious diseases.Here, the role played by at least two factors.Needless effects of an infectious agent may affect glucose levels.On the other hand, the disease is any such organism to stress, which should be the standard cascade of reactions starting with the ejection mechanism of glucose in the blood.. Taking certain medications can cause hyperglycemia.This is observed in the use of thiazide diuretics, hormonal agents, as well as during chemotherapy.. reason for ...
1 - Diabetes: High Blood Sugar High Blood Sugar Although people usually think about the long-term complications when it comes to diabetes, short-term or …. Mar 4, 2010 … Hyperglycemia happens when there is excess sugar level in blood. … Non- diabetic people, postprandial or post meal glucose level rarely go …. Jan 1, 2012 … 1.0 Diagnosis and recognition of hyperglycemia and diabetes in the … 4.0 Management of hyperglycemia in the non-critical care setting.. Hyperglycemia Treatment ★★★ Hyperglycemia Treatment ★★★ Diabetes Diet Drinks ::The 3 Step Trick that Reverses Diabetes Permanently in As Little …. National Direct Diabetic Supply 26 Home Pharmacy Inc On a national scale, direct medical costs totaled over $175 billion, with indirect costs … referred to as patient-centered medical homes or PCMH. …. care, prescription medicine, diabetes supplies, and physician …. 15.12.2005 · Hyperglycemia Vs Diabetes Highlights ★★★ Hyperglycemia Vs Diabetes ★★★ ...
TY - JOUR. T1 - Cellular and molecular effects of hyperglycemia on ion channels in vascular smooth muscle. AU - Nieves-Cintrón, Madeline. AU - Flores-Tamez, Víctor A.. AU - Le, Thanhmai. AU - Baudel, Miguel Martín Aragón. AU - Navedo, Manuel F.. PY - 2020. Y1 - 2020. N2 - Diabetes affects millions of people worldwide. This devastating disease dramatically increases the risk of developing cardiovascular disorders. A hallmark metabolic abnormality in diabetes is hyperglycemia, which contributes to the pathogenesis of cardiovascular complications. These cardiovascular complications are, at least in part, related to hyperglycemia-induced molecular and cellular changes in the cells making up blood vessels. Whereas the mechanisms mediating endothelial dysfunction during hyperglycemia have been extensively examined, much less is known about how hyperglycemia impacts vascular smooth muscle function. Vascular smooth muscle function is exquisitely regulated by many ion channels, including several ...
In type 1 diabetic patients, insulin supplementation can never mimic the exquisite control of glucose by pancreatic insulin seen in normal individuals. Multiple finger pricks and insulin injections (three to four per day) mean poor patient compliance, repeated exposure to bouts of inadequate glucose control (and a shift in cardiac metabolism), and cardiovascular disease in the long term. To imitate this poorly controlled type 1 diabetic patient exposed to acute hyperglycemia, we used DZ. Measurement of LPL protein expression in the heart revealed no change after acute hyperglycemia. However, the drawback with this measurement is that it does not distinguish active LPL from its inactive monomeric form. Using the heparin-sepharose column, our data for the first time show that acute hyperglycemia can indeed increase the amount of dimeric LPL in the heart. We are unaware of a similar increase in dimeric LPL in other physiology or pathology. In fact, the reverse is often seen with lipid metabolism ...
Without treatment, high blood sugar levels can lead to severe dehydration. If you have surgery, you may develop an infection in your surgery wound, or it may not heal well. You may get a blood clot in your leg or arm. The clot may travel to your heart or brain and cause life-threatening problems, such as a heart attack or stroke. Hyperglycemia may cause pancreatitis. Hyperglycemia can also lead to diabetes. Hyperglycemia can damage your nerves, veins, arteries, and organs over time. Damage to arteries may increase your risk for a heart attack or stroke ...
Chronic hyperglycemia can lead to chronic activation of the nutrient-sensing serine/threonine protein kinase, mammalian Target of Rapamycin (mTOR) in β cells. Activated mTOR triggers serine/threonine phosphorylation of IRS-2 and its subsequent proteosomal degradation, leading to increased β-cell apoptosis (39). It should be noted, however, that chronic hyperglycemia can also trigger β-cell apoptosis by additional mechanisms, collectively referred to as glucotoxicity. These mechanisms include the generation of potentially damaging reactive-oxygen species (ROS) as a consequence of chronically increased glucose metabolism in β cells (40); chronic elevation of intracellular [Ca2+] to cytotoxic levels (3); a marked up-regulation in the synthesis of β-cell secretory granule proteins, including pro-insulin and pro-Islet Amyloid Associated Peptide (proIAPP), which in turn could promote ER stress (3, 41); and a glucose-induced increase in local interleukin-1β (IL-1β) production (42). Some of ...
Its not always the case that its easy to forgive and forget, particularly when it comes to past memories. The concept of the legacy effect or hyperglycemic memory describes the deferred consequence of antecedent glycemic status on the development of diabetic complications. Anyone researching chronic hyperglycemia appreciates that glucose is still considered the major risk factor implicated in the development and progression of diabetic vascular complications. Now, the same can be concluded for transient hyperglycemia. Large clinical studies have demonstrated that prior glycemic control has a sustained benefit in reducing subsequent diabetic complications.1-4 The Diabetes Control and Complications Trial (DCCT) and the follow-up study, Epidemiology of Diabetes Interventions and Complications (EDIC) have determined that episodes of poor glycemic control can lead many years later to the long-term complications of diabetes.5,6 The DCCT study was designed to compare intensive versus conventional ...
Acute illness is typically associated with the so-called stress-induced hyperglycaemia, defined as a transient hyperglycaemia in patients without previous evidence of diabetes.1 The strong relationship between stress hyperglycaemia and poor outcome is largely established and actually validates hyperglycaemia as a marker of illness severity.
Purpose: : Insulin resistance and altered insulin release are the pathogenetic mechanisms underlying the development of hyperglycemia in subjects with type 2 diabetes mellitus (T2DM). Microvascular complications, such as retinopathy, arise as a consequence of chronic hyperglycemia, eventually leading to blindness. Initially, the natural history of T2DM includes a period of normal or near-normal fasting plasma glucose levels and marked postprandial glycemic excursions. The impact of these glycemic spikes on retinal function is still matter of controversy. The aim of the present study was to develop a model of mild type 2 diabetes in rats (combining diet-induced insulin resistance and a slight β-cell secretory impairment) in order to study early retinopathic changes in rodents with slight fasting hyperglycemia and markedly elevated postprandial glucose levels. Methods: : Adult male Wistar rats received tap water and citrate buffer i.p. (Group 1), tap water with 30% w/v sucrose and citrate buffer ...
Krzeczkowski JE, Boylan K, Arbuckle TE, Dodds L, Muckle G, Fraser WD, Favotto LA, Van Lieshout RJ, on behalf of The MIREC Study Group. Early Human Development. 2018 Oct;125:8-16. doi: 10.1016/j.earlhumdev.2018.08.005.. Pre-pregnancy obesity (adiposity) or maternal high blood glucose (hyperglycemia) have been linked to altered brain development in infants. A babys brain is rapidly developing both during pregnancy and in early life. Thus, maternal adiposity or hyperglycemia during pregnancy may impact the childs cognition (IQ) and behavior. This study was designed to look at the associations between pre-pregnancy adiposity or hyperglycemia and child IQ and behavior at around 3 years of age.. Data from 808 mother-child pairs from the MIREC-CD Plus study were analysed. Pre-pregnancy adiposity was assessed by calculating the womans body mass index (BMI: weight in kg/height in m2). If the women had gestational diabetes or impaired glucose tolerance (measures of high blood glucose), they were ...
The current goal of diabetes therapy is to reduce time-averaged mean levels of glycemia, measured as HbA1c, to prevent diabetic complications. However, HbA1c only explains ,25% of the variation in risk of developing complications. Because HbA1c does not correlate with glycemic variability when adjusted for mean blood glucose, we hypothesized that transient spikes of hyperglycemia may be an HbA1c-independent risk factor for diabetic complications. We show that transient hyperglycemia induces long-lasting activating epigenetic changes in the promoter of the nuclear factor κB (NF-κB) subunit p65 in aortic endothelial cells both in vitro and in nondiabetic mice, which cause increased p65 gene expression. Both the epigenetic changes and the gene expression changes persist for at least 6 d of subsequent normal glycemia, as do NF-κB-induced increases in monocyte chemoattractant protein 1 and vascular cell adhesion molecule 1 expression. Hyperglycemia-induced epigenetic changes and increased p65 ...
Definition of hyperglycemia management in the Legal Dictionary - by Free online English dictionary and encyclopedia. What is hyperglycemia management? Meaning of hyperglycemia management as a legal term. What does hyperglycemia management mean in law?
Definition of hyperglycemia management in the Financial Dictionary - by Free online English dictionary and encyclopedia. What is hyperglycemia management? Meaning of hyperglycemia management as a finance term. What does hyperglycemia management mean in finance?
TY - JOUR. T1 - The Twilight Saga of insulin administration in hyperglycemic patients undergoing 18F-FDG PET. AU - Lin, Yuh Feng. AU - Yu, Fu Chiu. AU - Chiu, Jainn Shiun. PY - 2010/3. Y1 - 2010/3. UR - http://www.scopus.com/inward/record.url?scp=77950350349&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=77950350349&partnerID=8YFLogxK. U2 - 10.2967/jnumed.109.070185. DO - 10.2967/jnumed.109.070185. M3 - Article. C2 - 20150262. AN - SCOPUS:77950350349. VL - 51. SP - 497. JO - Journal of Nuclear Medicine. JF - Journal of Nuclear Medicine. SN - 0161-5505. IS - 3. ER - ...
Our large, nationally representative study of elderly patients hospitalized with AMI indicates that the nature of the relationship between admission glucose and mortality is different in patients with and without recognized diabetes. Elevated glucose is common, infrequently treated, and associated with a steep, linear mortality increase in patients without recognized diabetes. In contrast, elevated glucose levels are not associated with an increased relative risk of mortality in patients with diabetes, except at severe levels of hyperglycemia. Surprisingly, elevated admission glucose confers at least as high or a higher risk of 30-day and 1-year mortality in patients without known diabetes as in those with diabetes.. Our study substantially expands the current understanding of the relationship between admission glucose values and adverse outcomes in patients with AMI. First, we directly compared the nature of the relationship between elevated glucose and mortality in patients with and without ...
Blood glucose is commonly considered too high if it is higher than 130 mg/dl before a meal or higher than 180 mg/dl two hours after the first bite of a meal. However, most of the signs and symptoms of high blood glucose dont appear until the blood glucose level is higher than 250 mg/dl. Some of the symptoms have a rapid onset, while others require a long period of high blood glucose to set in.Its important to note that individuals differ in their sensitivity to the effects of high blood glucose: Some people feel symptoms more quickly or more strongly than others. But each sign or symptom has a biological underpinning, or a specific cause behind the effect.Hyperglycemia can be acute or chronic. Acute hyperglycemialasts only briefly and is often the result of a high-carbohydrate meal, a missed dose of medicine, stress, or illness. Chronic hyperglycemia, on the other hand, is a state of long-term elevated blood glucose. It is often the result of undiagnosed diabetes or of an inadequate diabetes ...
By AMERICAN HEART ASSOCIATION NEWS. A condition known as stress hyperglycemia, sometimes called stress diabetes, can occur temporarily after a heart attack or stroke. Even in non-diabetic patients, blood glucose levels may spike during recovery. Such spikes are problematic: People diagnosed with acute stress hyperglycemia are more likely to die […]. ...
The aim of diabetes treatment is to keep blood sugar levels as near to normal as possible. But if you have diabetes, no matter how careful you are, youre likely to experience hyperglycaemia at some point.. Its important to be able to recognise and treat hyperglycaemia, as it can lead to serious health problems if left untreated.. Occasional mild episodes are not usually a cause for concern and can be treated quite easily or may return to normal on their own. But hyperglycaemia can be potentially dangerous if blood sugar levels become very high or stay high for long periods.. Very high blood sugar levels can cause life-threatening complications, such as:. ...
When to Seek Medical Care for High Blood Sugar (Hyperglycemia) Questions to Ask Your Doctor about High Blood Sugar (Hyperglycemia) Self-Care at Home for High Blood Sugar (Hyperglycemia)
In a retrospective analysis of a national database of hospital admissions, David McAllister and colleagues identify the 3-year risk of diabetes of hospitalized patients with hyperglycemia in Scotland. Please see later in the article for the Editors Summary
Journal of Diabetes Research is a peer-reviewed, Open Access journal that publishes research articles, review articles, and clinical studies related to type 1 and type 2 diabetes. The journal welcomes submissions focusing on the epidemiology, etiology, pathogenesis, management, and prevention of diabetes, as well as associated complications, such as diabetic retinopathy, neuropathy and nephropathy.
Influence of hyperinsulinaemia and/or hyperglycaemia on proinflammatory mRNA levels. Six subjects were studied on four separate occasions: during a lower insuli
Hyperglycemia commonly occurs in patients who are acutely ill, in a variety of clinical situations. Generally, moderate hyperglycemia in critically ill patients was thought to be beneficial; however, the degree of hyperglycemia on admission and the duration of hyperglycemia during critical illness are now recognized markers of adverse outcome. The use of insulin therapy to maintain normoglycemia for at least a few days improves survival and reduces morbidity in patients who are in a surgical intensive care unit (ICU), as shown by a large, randomized, controlled study. These results were recently confirmed by two studies--a randomized, controlled study of patients in a medical ICU, and a prospective, observational study of a heterogeneous patient population admitted to a mixed medical and surgical ICU. Results of multicenter trials that investigated tight blood-glucose control in critically ill patients are, however, still lacking. While we await those multicenter results, the current evidence ...
Abstract of Paper: THE EFFECT OF HYPERGLYCEMIA ON SERUM TRANSFORMING GROWTH FACTOR-B1 (TGF-B1) LEVEL AND THEIR RELATIONS TO DIABETIC NEPHROPATHY IN PATIENTS WITH CONTROLLED TYPE 2 DIABETES MELLITUS , Author: Medhat Abdel Monem*, Awad EI-Abd*, Mosad Odah*, Ashraf Talaat** and Inas Abdel Monem* , Year: 2005 , Faculty of Medicine, Benha University
Hyperglycemia is a driving force of late diabetic complications, making it necessary to understand not only indirect effects of glucose, such as the AGE-mediated cellular effects, but also direct effects of glucose. Several studies have shown that even an acute increase in blood glucose may impair the physiological homeostasis of many systems (2,3), such as the balance of free radicals/anti-oxidants. Furthermore, hyperglycemia increases adhe-sion molecules such as intracellular adhesion molecule (ICAM)-1 in type 2 diabetic patients (4), augments leukocyte-endothelial interaction (48), and suppresses flow-mediated endothelium-dependent vasodilation of brachial artery (6,7). This is explained by an overshoot of superoxide anions resulting in increased nitric oxide degradation. The mechanisms through which acute hyperglycemia exerts these effects may be the production of free radicals. As shown in the present study, the formation of free radicals can be detected on the molecular level by the ...
The PI3K/AKT pathway is constitutively active in many human malignancies. Signaling through this pathway plays a critical role in promoting cancer cell proliferation, survival, and chemoresistance; thus, intense efforts are under way to develop inhibitors of AKT as cancer therapy. The novel pan-AKT kinase inhibitor, GSK690693, is currently being evaluated in a phase I clinical trial for patients with solid tumors or lymphoma. The potential side effects of GSK690693 include transient hyperglycemia and hyperinsulinemia as observed in preclinical animal models (Figs. 1 and 2). As described previously, daily administration of GSK690693 (30 mg/kg intraperitoneally) for 21 days was well tolerated in mice (24) and there was no significant difference in the blood glucose elevation between days 1 and 21, suggesting that GSK690693-induced hyperglycemic effect remains transient with repeat dosing. Hyperglycemia was also observed in patients treated with perifosine and triciribine phosphate, both of which ...
The impact of hyperglycemia on mortality and discharge destination of community-dwelling older adults with staphylococcus aureus bacteremia Conference Paper ...
Kim, M S. and Urano, M, The effect of hyperglycemia on the combined hyperthermia and chemotherpay (cyclophosphamide). Abstr. (1982). Subject Strain Bibliography 1982. 3890 ...
Reducing the burden of long-term complications in type 2 diabetic patients remains a major task, and represents a huge challenge. Whilst tight glycemic control has been shown to reduce the risk of microvascular complications, controversy remains regarding the benefit of intensive treatment in relation to the prevention of cardiovascular events. Recent large trials (including ACCORD, ADVANCE, and VADT) were unable to show a significant impact of glycemic control on cardiovascular events. Also, it has been argued that these trials included patients with a long duration of the disease, and with previous unsatisfactory glycemic control. Chronic exposure to hyperglycemia may cause a kind of negative metabolic memory, and thereby reduce the potential impact of good glycemic control. This concept has been corroborated by the UKPDS which recruited only subjects with newly diagnosed diabetes and without prior cardiovascular events. In these patients, early achievement of glycemic control translated into a long
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Title: IGF-I Signaling in Response to Hyperglycemia and the Development of Diabetic Complications. VOLUME: 7 ISSUE: 4. Author(s):David Clemmons, Laura Maile, Gang Xi, Xinchun Shen and Yashwanth Radhakrishnan. Affiliation:CB &# 7170, 8025 Burnett Womack Division of Endocrinology, University of North Carolina, Chapel Hill, NC 27599-7170, USA.. Keywords:Mitogen, Vascular smooth muscle, Atherosclerosis, Retinopathy, Dedifferentiation, Hyperglycemia, Diabetic Complications, IGF-I Signaling, αVβ3 LIGANDS, Mitogen activated protein kinase. Abstract:IGF-I is structurally related to proinsulin and when administered to human subjects it enhances insulin sensitivity. However because of its growth promoting properties and its relationship to growth hormone, it has been proposed as a etiologic factor in the development of diabetic complications. This review discusses recently published data regarding the ability of hyperglycemia to sensitize cells that are capable of dedifferentiating to the growth ...
Diabetes Care in the Hospital Setting ADA Standards 2016. Hospital Discharge Algorithm 2014 Diabetes Care. Management of Hyperglycemia in Hospitalized Patients in the Non-Critical Care Setting: An Endocrine Society Clinical Practice Guideline 2012 » A consensus statement that provides evidence based guidelines on inpatient glucose management for the non critical setting.. Clinical Guidelines for the Management of Hyperglycemia in Hospitalized Patients in a Non-Critical Care Setting » Powerpoint Slide Presentation 2011. Management of Diabetes and Hyperglycemia in Hospitalized-Patients 2014 Endotext-ncbi-bookshelf. Creative Strategies to Improve Diabetes Care in the Inpatient Setting » this article is a guide to setting up an inpatient diabetes program with limited resources and staff. Authored by Beverly Thomassian and based on her experience setting up a diabetes program at Stanford Medical Center.. Consensus Statement on Inpatient Glycemic Control, 2009 » American Association of Clinical ...
The mention a concept of metabolic memory of renal cells and epigenomics in diabetes is new. The question of whether transient hyperglycemia ( leading to a memory of that in the renal cells) due to glycosolated end products or AGE, can induce epigenetic modifications of gene expression by affecting the methylation of particular parts of the genome is what is discussed in one of the articles. Metobolic memory is referred to as if the cells have seen prior hyperglycemia, they keep that memory and can later on return via epigenetic mechanism to lead to diabetic disease ...
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Sepsis, renal impairment with electrolyte imbalance, and low blood pressure were independent prognostic factors of mortality among patients with severe hyperglycemia in the emergency department.
If an IV infusion of 10% dextrose in water is initiated then the nurse must monitor for: •Circulatory overload •Hyperglycemia • ...
Somogyi, M; Kirstein, M (1938). "Insulin as a cause of extreme hyperglycemia and instability". Weekly Bulletin of the St Louis ... The Chronic Somogyi rebound, a form of post-hypoglycemic hyperglycemia that Somogyi theorized could occur as a defensive ... As of 2011-05-28, the electronic text is not open access). "Somogyi Phenomenon - Rebound Hyperglycemia". Diabetes.co.uk. 15 ...
Hiebert Linda M.; Han Juying & Mandal Anil Kumar (2014). "Glycosaminoglycans, Hyperglycemia, and Disease". Antioxidants & Redox ...
Hyperglycemia affects the pancreas, kidneys, and body's tissues. Characterization of hyperglycemia is high blood glucose, high ... Hyperglycemia A condition characterized as high blood glucose, which occurs when the body has too little insulin or when the ... "Hyperglycemia (High Blood Glucose)". American Diabetes Association. Retrieved 2017-11-07. "Hypoglycemia (Low Blood Glucose)". ...
Hyperglycemia hyperosmolar state[edit]. This article needs additional citations for verification. Please help improve this ... Diabetic ketoacidosis advanced enough to result in unconsciousness from a combination of severe hyperglycemia, dehydration and ... Hyperosmolar nonketotic coma in which extreme hyperglycemia and dehydration alone are sufficient to cause unconsciousness. ... Acute complications include hypoglycemia and hyperglycemia, diabetic coma and nonketotic hyperosmolar coma. Chronic ...
Johnson, SF; Loge, RV (Mar 1988). "Palinopsia due to nonketotic hyperglycemia". The Western Journal of Medicine. 148 (3): 331-2 ... Causes of seizures that are reported to cause palinopsia include metabolic disturbances (hyperglycemia, carnitine deficiency), ...
Hyperglycemia Hypoglycemia Khatib, Oussama MN (2006). Guidelines for the prevention, management and care of diabetes mellitus. ... Glucose tests can reveal temporary/long-term hyperglycemia or hypoglycemia. These conditions may not have obvious symptoms and ...
These effects cause maintenance of hyperglycemia. Because sodium is absorbed at the same time as glucose via SGLT-2, the ...
One simple way to determine if nocturnal hypoglycemia may be causing morning hyperglycemia is to have the patient have a high ... Also called the Somogyi effect and posthypoglycemic hyperglycemia, it is a rebounding high blood sugar that is a response to ... Michael Somogyi (www.whonamedit.com) Somogyi, M; Kirstein, M (1938). "Insulin as a cause of extreme hyperglycemia and ... Occasionally, insufficient insulin can result in hyperglycemia. The appropriate response is to take a correction dose of ...
The resultant hyperglycemia promotes further insulin release. As glucose concentration eventually falls, insulin secretion also ...
Xiu F, Stanojcic M, Diao L, Jeschke MG (8 May 2014). "Stress hyperglycemia, insulin treatment, and innate immune cells". ... Decreases in neutrophil function have been linked to hyperglycemia. Dysfunction in the neutrophil biochemical pathway ... myeloperoxidase as well as reduced degranulation are associated with hyperglycemia. The Absolute neutrophil count (ANC) is also ...
While the hyperglycemia itself is not the cause of the hemiballistic movements, it has been suggested that petechial hemorrhage ... This could be hyperglycemia, infections, or neoplastic lesions. Some patients may not even need treatment because the disorder ... which suggests that there may be some genetic disposition to development of hemiballismus as a result of hyperglycemia. ... Play media Patients with nonketotic hyperglycemia can develop hemiballismus as a complication to the disease through the ...
... and/or hyperglycemia. A CT scan is the first choice modality for workup of solid masses in the kidneys. Nevertheless, ...
Hyperglycemia increases O-GlcNAcylation, leading to insulin resistance. Increased O-GlcNAcylation due to hyperglycemia is ...
Long-term hyperglycemia causes many health problems including heart disease, cancer, eye, kidney, and nerve damage. Blood sugar ... They include hyperglycemia, hypoglycemia, impaired glucose tolerance test, impaired fasting glucose, among others. If blood ... The most common cause of hyperglycemia is diabetes. When diabetes is the cause, physicians typically recommend an anti-diabetic ...
GP and G6Pase are induced by chronic hyperglycemia. High levels of blood sugar increased their expression and activity, which ...
Postprandial hyperglycemia is a risk factor associated with diabetes. A 1998 study shows that it also presents an increased ...
Further, the decrease of tissue sensitivity to insulin leads to xylazine-induced hyperglycemia and a reduction of tissue ... Xylazine administration can lead to diabetes mellitus and hyperglycemia. Other possible side effects that can occur are ... and hyperglycemia monitoring. Physicians typically recommend which detoxification treatment should be used to manage possible ... "Xylazine-induced reduction of tissue sensitivity to insulin leads to acute hyperglycemia in diabetic and normoglycemic monkeys ...
They do not produce hypoglycemia; instead, they reduce basal and postprandial hyperglycemia in diabetics. Biguanides may ... other conditions where buformin is unlikely to control the hyperglycemia, renal or hepatic impairment, heart failure, recent ...
Colwell, J. A.; Lein, A. (1967). "Diminished Insulin Response to Hyperglycemia in Prediabetes and Diabetes". Diabetes. 16 (8): ...
Chronic administration of thiazides is associated with the increase of insulin resistance which can lead to hyperglycemia. ... Hyperglycemia Hyperlipidemia Hyperuricemia Hypercalcemia Hyponatremia Hypomagnesemia Hypocalciuria Thiazide diuretics control ... Drug-Induced Hyperglycemia". Diabetes Spectrum. 24 (4): 234-238. doi:10.2337/diaspect.24.4.234. ISSN 1040-9165. http://www. ...
Long-term hyperglycemia causes many health problems including heart disease, cancer, eye, kidney, and nerve damage. Blood sugar ... A persistently high level is referred to as hyperglycemia; low levels are referred to as hypoglycemia. Diabetes mellitus is ... Somogyi M (May 1948). "Studies of arteriovenous differences in blood sugar; effect of alimentary hyperglycemia on the rate of ... Without discounting the potentially quite serious conditions and risks due to or oftentimes accompanying hyperglycemia, ...
Can be caused by insulin deficiency or resultant hyperglycemia. Alport syndrome is a X-linked hereditary nephritis caused by ...
Sluggish movement of the small intestine can cause bacterial overgrowth, made worse by the presence of hyperglycemia. This ... The main risk factor for diabetic neuropathy is hyperglycemia. In the DCCT (Diabetes Control and Complications Trial, 1995) ...
Ternatin is a fungal isolate that may affect hyperglycemia. Numerous fungi have well-documented psychotropic effects, some of ...
Senescent Cd8+ T cells could be utilized as a biomarker to signal the transition from pre-diabetes to overt hyperglycemia. ... "Senescent T Cells Predict the Development of Hyperglycemia in Humans". Diabetes. 68 (1): 156-162. doi:10.2337/db17-1218. ISSN ... an increased frequency of senescent CD8+ T cells in the peripheral blood is associated with the development of hyperglycemia ...
Ternatin is a mushroom heptapeptide that suppresses hyperglycemia in vivo. Kobayashi, M.; Kawashima, H.; Takemori, K.; Ito, H ... and its derivative suppress hyperglycemia and hepatic fatty acid synthesis in spontaneously diabetic KK-A(y) mice". Biochemical ...
Hyperglycemia, a high blood sugar level, is the opposite condition. Throughout a 24‑hour period, blood plasma glucose levels ... Overfeeding does not speed recovery, and if the person has diabetes, it will simply produce hyperglycemia afterwards. A ...
Postprandial hyperglycemia (PPHG) is high blood sugar following a meal. It can be evaluated in a postprandial glucose test. ...
Common (>1%) side effects include insulin resistance, hyperglycemia and lipodystrophy. Nelfinavir can produce a range of ...
... its called hyperglycemia. A major goal in controlling diabetes is to keep blood sugar levels as close to the desired range as ... Signs & Symptoms of Hyperglycemia. The symptoms of hyperglycemia are similar to those that happen when someone is diagnosed ... Hyperglycemia is the hallmark of diabetes - it happens when the body either cant make insulin (type 1 diabetes) or cant ... Extreme thirst: Kids with hyperglycemia who lose a lot of fluid from urinating often become very thirsty and may drink a lot in ...
Chronic hyperglycemia can be measured via the HbA1c test. The definition of acute hyperglycemia varies by study, with mmol/l ... Acute hyperglycemia can be treated by direct administration of insulin in most cases. Severe hyperglycemia can be treated with ... In fact, chronic hyperglycemia is the defining characteristic of the disease. Intermittent hyperglycemia may be present in ... Also, patients with immune-mediated diabetes, can change from modest fasting hyperglycemia to severe hyperglycemia and even ...
Steroid diabetes is a specific and prolonged form of stress hyperglycemia. People who have experienced stress hyperglycemia ... Stress hyperglycemia (also called stress diabetes or diabetes of injury) is a medical term referring to transient elevation of ... Stress hyperglycemia is especially common in patients with hypertonic dehydration and those with elevated catecholamine levels ... Diagnosing patient can be complex, as there are no guidelines that specifically define stress hyperglycemia. One of the most ...
Definition Hyperglycemia is a complex metabolic condition characterized by abnormally high levels of blood sugar [1] (blood ... Hyperglycemia. Hyperglycemia, or high blood sugar, is the result of either too little insulin or of the bodys inefficient use ... Failure to address hyperglycemia results in dehydration and ketoacidosis . Over the long term, hyperglycemia causes heart ... Hyperglycemia. Definition. Hyperglycemia is a complex metabolic condition characterized by abnormally high levels of blood ...
Health Information on Hyperglycemia: MedlinePlus Multiple Languages Collection ... Hyperglycemia: MedlinePlus Health Topic - English Hiperglucemia: Tema de salud de MedlinePlus - español (Spanish) ... URL of this page: https://medlineplus.gov/languages/hyperglycemia.html Other topics A-Z. ...
... its called hyperglycemia. A major goal in controlling diabetes is to keep blood sugar levels as close to the desired range as ... Hyperglycemia and Diabetic Ketoacidosis. Resources. Please Note: By clicking a link to any resource listed on this page, you ...
Hyperglycemia is abnormally high blood sugar. The medical term for blood sugar is blood glucose. ... Babies with hyperglycemia often have no symptoms.. Sometimes, babies with high blood sugar will produce large amounts of urine ... Hyperglycemia is abnormally high blood sugar. The medical term for blood sugar is blood glucose. ...
Hyperglycemia is another term for high blood sugar levels. This can be an indicator of diabetes and can cause severe health ... Hyperglycemia refers to high levels of sugar, or glucose, in the blood. It occurs when the body does not produce or use enough ... Hyperglycemia causes symptoms that a person will either detect during self-monitoring or notice in other ways, including:. * ... People with prolonged hyperglycemia might be more prone to bacterial and fungal infections, such as boils, jock itch, athletes ...
... hyperglycemia vs type 2 diabetes, how long until diabetes cure news, m power yoga parking ... Hyperglycemia vs type 2 diabetes,diabetes oral medication type 2 60v,2000 chevy s10 - Reviews It occurred to us as we were ...
Hyperglycemia is defined as too high a blood sugar (glucose) level. Description As you regulate your blood glucose and keep you ... Hyperglycemia: Hyperglycemia, or high blood glucose, is the condition found in individuals with diabetes, either insulin- ...
Hyperglycemia and adverse pregnancy outcomes.. HAPO Study Cooperative Research Group1, Metzger BE, Lowe LP, Dyer AR, Trimble ER ... Non-diabetic maternal hyperglycaemia was associated with adverse pregnancy outcomes. [Evid Based Med. 2008] ... Nondiabetic maternal hyperglycemia was associated with adverse pregnancy outcomes. [ACP J Club. 2008] ... It is controversial whether maternal hyperglycemia less severe than that in diabetes mellitus is associated with increased ...
Hyperglycemia, or high blood sugar, is a serious problem in diabetes. WebMD explains the causes and prevention of this ... Fasting hyperglycemia. This is blood sugar thats higher than 130 mg/dL (milligrams per deciliter) after not eating or drinking ... Postprandial or after-meal hyperglycemia. This is blood sugar thats higher than 180 mg/dL 2 hours after you eat. People ... High blood sugar, or hyperglycemia, is a major concern, and can affect people with both type 1 and type 2 diabetes . There are ...
Hyperglycemia is a key feature of diabetes, which occurs when insulin does not process glucose effectively. Triggers include a ... Blurred vision is a symptom of severe hyperglycemia.. Hyperglycemia can be dangerous, as it often does not cause symptoms until ... "The link between hyperglycemia and diabetes." Medical News Today. MediLexicon, Intl., 26 Feb. 2019. Web.. 17 Jul. 2019. ,https ... Hyperglycemia and diabetes. People with diabetes have consistently high blood sugar and ongoing monitoring is often necessary. ...
HAART, Dyslipidemia, and Hyperglycemia. Alvan E. Fisher, M.D.. Feb. 21, 2012. ... as well as hyperglycemia leading to diabetes. Dr. Morris Shambelan from San Francisco summarized the current understanding of ... https://www.thebody.com/article/haart-dyslipidemia-hyperglycemia. Approved HIV MedicationsNews. ... as well as hyperglycemia leading to d ...
hyperglycemia Hyperglycemia is a condition when a person has increased levels of blood sugar and is usually the first sign of ...
Individuals who have type 1 or type 2 diabetes often have difficulty with their feet. In the extreme, these issues can force them to have their feet or lower legs amputated. In fact, the American Orthopedic Foot and Ankle Society estimates that diabetes is the cause of more than 60,000 lower extremity amputations each year ...
Raskin P, Pietin AD, Unger R, et al. The effect of diabetic control on the width of skeletal-muscle capillary basement membrane in patients with Type I diabetes mellitus. N Engl J Med 1983;309:1546-50PubMedCrossRefGoogle Scholar ...
... nearly half of all COVID-19 patients without a prior diabetes diagnosis had hyperglycemia, and those individuals were more ... Hyperglycemia Predicts COVID-19 Death, Complications The study involved consecutive patients with COVID-19 and definitive 28- ... Several previous studies have demonstrated a link between hyperglycemia and worse outcomes in COVID-19, and at least one ... Cite this: Hyperglycemia Predicts COVID-19 Death Even Without Diabetes - Medscape - Jul 13, 2020. ...
Hyperglycemia reduces proteoglycan levels in tendons.. Burner T1, Gohr C, Mitton-Fitzgerald E, Rosenthal AK. ... Hyperglycemia produces a reduction in PG levels related to decreased synthesis or sulfation of glycosaminoglycans, which may ... Relative quantities of individual PGs were unchanged by exposure to hyperglycemia and mRNAs for PGs were variably affected. ... which commonly mediates some effects of hyperglycemia, were also measured and the effects of free radical scavengers on (35)S- ...
Read about hyperglycaemia (high blood sugar), a common problem that affects people with diabetes. Find out its causes, symptoms ... How to prevent hyperglycaemia. There are simple ways to reduce your risk of severe or prolonged hyperglycaemia:. *Be careful ... Symptoms of hyperglycaemia. Symptoms of hyperglycaemia in people with diabetes tend to develop slowly over a few days or weeks. ... Treating hyperglycaemia. If you have been diagnosed with diabetes and have symptoms of hyperglycaemia, follow the advice your ...
... Blood glucose levels fluctuate differently depending on peoples type of diabetes, so an ... If you dont manage your blood glucose levels and you are diabetic, it can result in hyperglycaemia. This occurs when there are ...
Share your story with this active Hyperglycemia community of thousands of participants. ...
Hyperglycemia occurs when the levels get too high. This can happen to someone who has diabetes but doesnt know it yet. It also ... Signs of hyperglycemia include increased urination (peeing), extreme thirst, and unexplained weight loss. ...
Other models find that hyperglycaemia is not independent predictor. *Carl Counsell, Clinical research fellowa, ... hyperglycaemia was not (1.66; 0.93 to 2.97). Neither of these variables was an independent predictor of death or disability ( ... we redefined hyperglycaemia as glucose concentration ,8mmol/l to allow direct comparison with the results of Weir … ... 3 A history of diabetes mellitus and the presence of acute hyperglycaemia (glucose concentration ,12 mmol/l) were two of about ...
hyperglycemia definition: an abnormally high concentration of sugar in the bloodOrigin of hyperglycemiaModern Latin from hyper ... hyperglycemia. hy·per·gly·ce·mi·a. an abnormally high concentration of sugar in the blood ... Unless hyperglycemia is obvious (e.g., blood glucose levels are extremely high or the child experiences DKA), the fasting or ... In severe cases of hyperglycemia in which cerebral edema occurs, mannitol is administered at the first sign of edema, such as ...
Patients with type 1 DM can have coexisting illnesses that aggravate hyperglycemia, such as infection, coronary artery disease ... Patients with type 1 DM can have coexisting illnesses that aggravate hyperglycemia, such as infection, coronary artery disease ... encoded search term (Which type 1 diabetes mellitus (DM) comorbidities may aggravate hyperglycemia?) and Which type 1 diabetes ... Which type 1 diabetes mellitus (DM) comorbidities may aggravate hyperglycemia?. Updated: Oct 13, 2020 ...
Hyperglycemia in diabetes can occur for many reasons. Know the causes, symptoms and treatments of high blood sugar and when to ... If you have any signs or symptoms of severe hyperglycemia - even if theyre subtle - check your blood sugar level. If your ... Take your medication as directed. If you have frequent episodes of hyperglycemia, your doctor may adjust the dosage or timing ... Adjust your insulin doses to control hyperglycemia. Adjustments to your insulin program or a supplement of short-acting insulin ...
... Fangming Xiu,1 Mile Stanojcic,1,2 Li Diao,1,2 and Marc G. ... Hyperglycemia (HG) and insulin resistance are the hallmarks of a profoundly altered metabolism in critical illness resulting ... A comprehensive review of published literatures on the effects of hyperglycemia and insulin on innate immunity in critical ... Innate immune system dysfunction via hyperglycemia is associated with a higher morbidity and mortality in critical illness. ...
Hyperglycemia in diabetes can occur for many reasons. Know the causes, symptoms and treatments of high blood sugar and when to ... High blood sugar (hyperglycemia) affects people who have diabetes. Several factors can contribute to hyperglycemia in people ... Its important to treat hyperglycemia, because if left untreated, hyperglycemia can become severe and lead to serious ... If hyperglycemia goes untreated, it can cause toxic acids (ketones) to build up in your blood and urine (ketoacidosis). Signs ...
... external resources ICD-10 R73.9 ICD-9 790.6 Hyperglycemia, hyperglycaemia, or high blood sugar is a condition in ... Acute Stress Hyperglycemia. *^ Giugliano D, Marfella R, Coppola L, et al (1997). "Vascular effects of acute hyperglycemia in ... Hyperglycemia, hyperglycaemia, or high blood sugar is a condition in which an excessive amount of glucose circulates in the ... Chronic hyperglycemia can be measured via the HbA1c test. The definition of acute hyperglycemia varies by study, with mmol/L ...
  • People who have experienced stress hyperglycemia during severe illness have a threefold risk of developing diabetes in subsequent years, and it may be appropriate to screen for diabetes in survivors of critical illness. (wikipedia.org)
  • Acute episodes of hyperglycemia without an obvious cause may indicate developing diabetes or a predisposition to the disorder. (bionity.com)
  • Levels of transforming growth factor β, which commonly mediates some effects of hyperglycemia, were also measured and the effects of free radical scavengers on (35)S-sulfate incorporation were determined. (nih.gov)
  • A comprehensive review of published literatures on the effects of hyperglycemia and insulin on innate immunity in critical illness was conducted. (hindawi.com)
  • Effects of hyperglycemia on corti. (mendeley.com)
  • Effects of hyperglycemia on cortical response to esophageal distension in normal subjects. (mendeley.com)
  • The aim of this study was to examine the effects of hyperglycemia on cortical potentials evoked by esophageal distension. (mendeley.com)
  • The ischemic penumbra appears to be the region that is sensitive to the effects of hyperglycemia. (uspharmacist.com)
  • We investigated the combination of ischemia and hyperglycemia in two experimental models of stroke and CA. The aims were to test the neuroprotective potential of the sulfonated nitrone 2-sulfophenyl-N-tert-butylnitrone (S-PBN) in focal hyperglycemic cerebral ischemia (1), to outline the short-terms effects of hyperglycemia in prolonged (2) and short CA (3) and to performed a global transcriptome analysis of brain from hyperglycemic and normoglycemic CA (4). (diva-portal.org)
  • As you regulate your blood glucose and keep your diabetes record, there are two problems that you need to be able to recognize and treat (with your personal physician's advice): hypoglycemia and hyperglycemia. (healthcentral.com)
  • Avoid hypoglycemia and hyperglycemia by checking your blood glucose (blood sugar) regularly and knowing the symptoms of each. (umassmed.edu)
  • Both hypoglycemia and hyperglycemia can cause brain injury. (brainandspinalcord.org)
  • To avoid episodes of hyperglycemia, take your usual insulin exactly as prescribed by your doctor (do not skip a dose! (everydayhealth.com)
  • A common cause of hyperglycemia in people with diabetes is the dawn phenomenon. (medicalnewstoday.com)
  • While noticeable symptoms of hyperglycemia do not often occur at a level below 250 mg/dl, people with diabetes should self-monitor regularly enough to catch glucose levels before they reach the stage where they cause symptoms. (medicalnewstoday.com)
  • This information focuses on hyperglycaemia in people with diabetes. (www.nhs.uk)
  • Symptoms of hyperglycaemia in people with diabetes tend to develop slowly over a few days or weeks. (www.nhs.uk)
  • Several factors can contribute to hyperglycemia in people with diabetes, including food and physical activity choices, illness, nondiabetes medications, or skipping or not taking enough glucose-lowering medication. (mayoclinic.org)
  • People with diabetes can get hyperglycemia from not eating the right foods or not taking medicines correctly. (ahrq.gov)
  • Hyperglycemia occurs when people with diabetes have too much sugar in their bloodstream. (diabetes.co.uk)
  • Innate immune system dysfunction via hyperglycemia is associated with a higher morbidity and mortality in critical illness. (hindawi.com)
  • Studies show that hyperglycemia adversely affects immune function, the cardiovascular system, the brain, and a host of other pathways implicated in the morbidity and mortality attributed to acute hyperglycemia. (uspharmacist.com)
  • Severe hyperglycemia is associated with increased morbidity and mortality in a variety of patients. (ajmc.com)
  • These images are a random sampling from a Bing search on the term "Medication Causes of Hyperglycemia. (fpnotebook.com)
  • Hyperglycemia occurs when you have a higher than usual level of glucose in your blood. (news-medical.net)
  • Hyperglycemia usually occurs slowly, over several hours or days. (healthcentral.com)
  • Hyperglycemia occurs when the levels get too high. (rchsd.org)
  • In severe cases of hyperglycemia in which cerebral edema occurs, mannitol is administered at the first sign of edema, such as unconsciousness, difficulty breathing, severe headache, irregular heartbeat, or seizures. (yourdictionary.com)
  • Hyperglycemia, or high blood glucose , often occurs in those with diabetes, but there are ways to keep it in check before it causes major problems. (wisegeek.com)
  • Hyperglycemia occurs when the level of glucose in the blood is higher than it should be. (akronchildrens.org)
  • Hyperglycaemia occurs in 30-40% of patients with acute ischaemic stroke, also in individuals without a known history of diabetes. (nih.gov)
  • Hyperglycemia is a condition that occurs when there is an abnormally high level of glucose in the bloodstream. (consumerinjurylawyers.com)
  • The risk of hyperglycemia varies among the different SGAs available on the market. (oncologynurseadvisor.com)
  • Obesity and overweight is an escalating problem among women of reproductive age globally with wide regional variance, ranging from approximately 20% in South Asia to over 90% in North and Central America, Northern and Southern Africa and West Asia and an estimated 42 million pregnancies are impacted by maternal overweight or obesity which increases risk of hyperglycemia in pregnancy (HIP). (figo.org)
  • additionally, both women born low birth weight, and women who are overweight and obese, are at increased risk of hyperglycemia in pregnancy. (figo.org)
  • Several previous studies have demonstrated a link between hyperglycemia and worse outcomes in COVID-19, and at least one diabetes diagnosis , but this is the first to focus specifically on that group of patients. (medscape.com)
  • In a study published this week in the JCI , Andrew Murphy's lab at the Baker IDI Heart and Diabetes Institute investigated the link between hyperglycemia and enhanced platelet production. (eurekalert.org)
  • citation needed] The following symptoms may be associated with acute or chronic hyperglycemia, with the first three composing the classic hyperglycemic triad:[citation needed] Polyphagia - frequent hunger, especially pronounced hunger Polydipsia - frequent thirst, especially excessive thirst Polyuria - increased volume of urination (not an increased frequency, although it is a common consequence) Blurred vision Fatigue Restlessness Weight loss Poor wound healing (cuts, scrapes, etc. (wikipedia.org)
  • citation needed] Signs and symptoms of diabetic ketoacidosis may include:[citation needed] Ketoacidosis Kussmaul hyperventilation (deep, rapid breathing) Confusion or a decreased level of consciousness Dehydration due to glycosuria and osmotic diuresis Increased thirst 'Fruity' smelling breath odor Nausea and vomiting Impairment of cognitive function, along with increased sadness and anxiety Weight loss Hyperglycemia causes a decrease in cognitive performance, specifically in processing speed, executive function, and performance. (wikipedia.org)
  • The first signs of hyperglycemia or ketoacidosis are frequent urination and increased thirst. (encyclopedia.com)
  • Signs of hyperglycemia include increased urination (peeing), extreme thirst, and unexplained weight loss. (rchsd.org)
  • Symptoms of hyperglycemia include frequent urination, weight loss, increased thirst and increased sugar levels in the urine, states Healthline. (reference.com)
  • Some symptoms of hyperglycemia include high blood glucose and sugar levels, frequent urination, and an increase in thirst, reports the American Diabetes As. (reference.com)
  • Hyperglycemia doesn't cause symptoms until glucose values are significantly elevated - usually above 180 to 200 milligrams per deciliter (mg/dL), or 10 to 11.1 millimoles per liter (mmol/L). Symptoms of hyperglycemia develop slowly over several days or weeks. (mayoclinic.org)
  • In general, the normal range for most people (fasting adults) is about 80 to 120 mg/dL or 4 to 7 mmol/L. A subject with a consistent range above 126 mg/dL or 7 mmol/L is generally held to have hyperglycemia, whereas a consistent range below 70 mg/dL or 4 mmol/L is considered hypoglycemic . (bionity.com)
  • The definition of acute hyperglycemia varies by study, with mmol/L levels from 8 to 15. (bionity.com)
  • In fact, hyperglycemia doesn't even cause symptoms until glucose levels are significantly high: above 200 milligrams per deciliter (mg/dL), or 11 millimoles per liter (mmol/L). The longer blood glucose levels stay high, the more serious the symptoms become. (everydayhealth.com)
  • We tested the possible interaction between ACE I/D polymorphism and uncontrolled type 1 diabetes by measuring glomerular filtration rate (GFR) and effective renal plasma flow (ERPF) during normoglycemia (≈5 mmol/L) and hyperglycemia (≈15 mmol/L) in 9 normoalbuminuric, normotensive type 1 diabetic subjects with the II genotype and 18 matched controls with the ID or DD genotype. (ahajournals.org)
  • Blurred vision is a symptom of severe hyperglycemia. (medicalnewstoday.com)
  • If you have any signs or symptoms of severe hyperglycemia - even if they're subtle - check your blood sugar level. (mayoclinic.org)
  • Check more frequently if you're ill or you're concerned about severe hyperglycemia or hypoglycemia. (mayoclinic.org)
  • Sepsis, renal impairment with electrolyte imbalance, and low blood pressure were independent prognostic factors of mortality among patients with severe hyperglycemia in the emergency department. (ajmc.com)
  • We undertook this study to identify prognostic factors of mortality among patients experiencing severe hyperglycemia in the emergency department (ED). (ajmc.com)
  • Among 733 patients with severe hyperglycemia, the 90-day mortality rate was 14.6% (n = 107). (ajmc.com)
  • Severe hyperglycemia after hospital admission for COVID-19 significantly increased mortality odds among individuals not in the ICU, according to a study published in Diabetes Care . (healio.com)
  • It is manifested by the sudden onset of severe HYPERGLYCEMIA, rapid progression to DIABETIC KETOACIDOSIS, and DEATH unless treated with insulin. (bioportfolio.com)
  • Dr. McLaughlin explains what the symptoms of hyperglycemia include. (empowher.com)
  • Acute hyperglycemia involving glucose levels that are extremely high is a medical emergency and can rapidly produce serious complications (such as fluid loss through osmotic diuresis). (wikipedia.org)
  • Chronic hyperglycemia (high blood sugar) injures the heart in patients without a history of heart disease or diabetes and is strongly associated with heart attacks and death in subjects with no coronary heart disease or history of heart failure. (wikipedia.org)
  • Hyperglycemia is a complex metabolic condition characterized by abnormally high levels of blood sugar (blood glucose) in circulating blood, usually as a result of diabetes mellitus (types 1 and 2), although it can sometimes occur in cystic fibrosis and near-drowning (submersion injury). (encyclopedia.com)
  • Over time as glucose production accelerates, the child develops hyperglycemia or glucotoxicity and lipotoxicity (hyperlipidemia or high fat levels in the blood) as well. (encyclopedia.com)
  • When blood glucose levels (also called blood sugar levels) are too high, it's called hyperglycemia . (kidshealth.org)
  • Hyperglycemia is abnormally high blood sugar. (medlineplus.gov)
  • Hyperglycemia refers to high levels of sugar, or glucose, in the blood. (medicalnewstoday.com)
  • Most people will experience an increase in blood sugar levels after eating an unusually large high-glucose meal, but people who experience consistent hyperglycemia may have problems with producing or using insulin . (medicalnewstoday.com)
  • Hyperglycemia is defined as too high a blood sugar (glucose) level. (healthcentral.com)
  • Hyperglycemia, or high blood glucose, is the condition found in individuals with diabetes , either insulin-dependent or non-insulin-dependent. (healthcentral.com)
  • Hyperglycemia, or high blood glucose, is a symptom that characterizes diabetes. (medicalnewstoday.com)
  • Hyperglycemia can be dangerous, as it often does not cause symptoms until glucose levels are very high. (medicalnewstoday.com)
  • Hyperglycaemia is the medical term for a high blood sugar (glucose) level. (www.nhs.uk)
  • But hyperglycaemia can be potentially dangerous if blood sugar levels become very high or stay high for long periods. (www.nhs.uk)
  • Regular home testing of blood sugar levels is also important to make sure that the treatment is working effectively and to avoid a diabetic emergency such as hypoglycemia (low blood sugar) or hyperglycemia (high blood sugar). (yourdictionary.com)
  • Unless hyperglycemia is obvious (e.g., blood glucose levels are extremely high or the child experiences DKA), the fasting or random plasma glucose test should be confirmed on a subsequent day with a repeat test. (yourdictionary.com)
  • High blood sugar (hyperglycemia) affects people who have diabetes. (mayoclinic.org)
  • As a result, glucose tends to build up in your bloodstream (hyperglycemia) and may reach dangerously high levels if not treated properly. (mayoclinic.org)
  • Hyperglycemia , hyperglycaemia , or high blood sugar is a condition in which an excessive amount of glucose circulates in the blood plasma . (bionity.com)
  • Certain eating disorders can produce acute non-diabetic hyperglycemia, as in the binge phase of bulimia nervosa, when the subject consumes a large amount of calories at once, frequently from foods that are high in simple and complex carbohydrates . (bionity.com)
  • A high proportion of patients suffering an acute stress such as stroke or myocardial infarction may develop hyperglycemia, even in the absence of a diagnosis of diabetes. (bionity.com)
  • Human and animal studies suggest that this is not benign, and that stress-induced hyperglycemia is associated with a high risk of mortality after both stroke and myocardial infarction. (bionity.com)
  • Diabetes is characterized by a high incidence of cardiovascular disease (CVD) ( 1 ), and poor control of hyperglycemia appears to play a significant role in the development of CVD in diabetes ( 2 ). (diabetesjournals.org)
  • Nondiabetic hyperglycemia means your blood glucose (sugar) level is high even though you do not have diabetes. (drugs.com)
  • Hyperglycemia means high blood sugar or glucose. (ahrq.gov)
  • Noticeable symptoms of hyperglycemia, or high blood glucose, are rare, and can develop over several days. (reference.com)
  • Many people who are on steroids for their disease, and develop high blood sugar levels (hyperglycemia ), will return to normal after the medication has been finished. (chemocare.com)
  • If you have an infection, your blood sugar may be briefly high, during the time that you are ill, resulting in a temporary hyperglycemia. (chemocare.com)
  • High blood sugar, which is called hyperglycemia , means that you have more sugar in your bloodstream than normal. (diabetesdaily.com)
  • Hyperglycemia is the technical term for when blood glucose levels (or blood sugar levels) are too high because the body isn't properly using - or doesn't make - the hormone insulin. (everydayhealth.com)
  • Hyperglycemia - wikipedia, the free encyclopedia, Hyperglycemia, or high blood sugar (also spelled hyperglycaemia or hyperglyc?mia, not to be confused with the opposite disorder, hypoglycemia) is a condition in. (amazonaws.com)
  • Whenever the glucose ( sugar ) level in one's blood rises high temporarily, this condition is known as hyperglycemia. (emedicinehealth.com)
  • Hyperglycemia refers to chronically high blood glucose (blood sugar) levels in people living with diabetes. (umassmed.edu)
  • Symptoms of high blood sugar (hyperglycemia) correspond with many of the symptoms of diabetes, unsurprisingly as a diabetes diagnosis relies on testing for high blood glucose. (wizzley.com)
  • The symptoms of high blood sugar (hyperglycemia) are often overlooked and mistaken for symptoms of other diseases and conditions. (wizzley.com)
  • Outside of the range, over 8 (UK) or 144 (US) for high blood sugar (hyperglycemia), is considered to be a symptom of diabetes. (wizzley.com)
  • As far as hyperglycemia is concerned, a level consistently above 7 (UK) or 126 (US) is deemed to be high, and an indicator that diabetes is present. (wizzley.com)
  • Hyperglycemia is when blood sugar is too high which often leads to diabetes diagnosis. (starmometer.com)
  • Hyperglycemia is the name given for high blood glucose levels. (diabetes.co.uk)
  • The hyperglycemia is an abnormally high blood glucose level. (easycalculation.com)
  • Abstract -Hyperglycemia causes capillary vasodilation and high glomerular capillary hydraulic pressure, which lead to glomerulosclerosis and hypertension in type 1 diabetic subjects. (ahajournals.org)
  • 14 In the present study, changes in glomerular capillary pressure were therefore estimated from those in GFR, effective renal plasma flow (ERPF), and mean arterial pressure (MAP) produced by the transition from normoglycemia to hyperglycemia in type 1 diabetics selected for their genetic predisposition to low or high ACE levels. (ahajournals.org)
  • Hyperglycemia (high blood sugar) also has negative effects, but generally does harm over time. (brainandspinalcord.org)
  • In untreated hyperglycemia, a condition called ketoacidosis may develop because decreased insulin levels increase the activity of hormone sensitive lipase. (wikipedia.org)
  • Hyperglycemia, also known as diabetic ketoacidosis, is a condition that develops over a period of a few days as the blood glucose levels of a type 1 or type 2 diabetic gradually rise. (encyclopedia.com)
  • If hyperglycemia goes untreated, it can cause toxic acids (ketones) to build up in your blood and urine (ketoacidosis). (mayoclinic.org)
  • If hyperglycemia remains untreated, it can result in heart or kidney disease, nerve damage, and diabetic ketoacidosis, reports Healthline. (reference.com)
  • 5. Maccario M, Messis CP, Vastola EF - Focal seizures as a manifestation of hyperglycemia without ketoacidosis. (scielo.br)
  • Hyperglycemia can also lead to serious health complications including Ketoacidosis, a diabetic coma. (consumerinjurylawyers.com)
  • Left untreated, hyperglycemia can lead to a condition called ketoacidosis, also known as diabetic ketoacidosis (DKA) or diabetic coma. (emedicinehealth.com)
  • Insulin is prescribed for treating type 1 diabetes mellitus, type 2 diabetes mellitus, gestational diabetes, diabetic ketoacidosis, and hyperosmolar hyperglycemia. (medindia.net)
  • Diabetic neuropathy may be a result of long-term hyperglycemia. (wikipedia.org)
  • Kidney failure, kidney disorders, and damage to your eyes, cardiovascular system, and other internal organs may result from long-term hyperglycemia. (chemocare.com)
  • Diabetes and obesity result from sucrose-induced hyperglycemia. (go.jp)
  • Here we show that polysaccharides obtained from soil bacteria inhibit sucrose-induced hyperglycemia in an in vivo silkworm evaluation system. (go.jp)
  • Paenibacillus polymyxa , Pantoea eucalypti , Variovorax boronicumulans , and Xanthomonas cynarae suppressed sucrose-induced hyperglycemia in silkworm insect larvae. (go.jp)
  • Our results suggest that silkworms provide an efficient screening system of bacterial polysaccharides that inhibit sucrose-induced hyperglycemia. (go.jp)
  • Many mechanisms have been proposed to explain this prothrombotic shift in hyperglycemia, such as a direct effect on gene transcription of coagulation factors caused by hyperglycemia-induced oxidative stress, loss of the endothelial glycocalyx layer, which harbours coagulation factors, and direct glycation of coagulation factors, altering their activity. (nih.gov)
  • This study indicates that spirulina is efficient in inhibiting hyperglycemia and oxidative stress induced by diabetes. (greenmedinfo.com)
  • Hyperglycemia inhibited Pax6 via oxidative stress and impaired eye development in the chick embryo, a new gestational diabetes mellitus model. (biologists.org)
  • Nearly half of hospitalized COVID-19 patients without a prior diabetes diagnosis have hyperglycemia, and the latter is an independent predictor of mortality at 28 days, new research indicates. (medscape.com)
  • In conclusion, the study provides evidence of the harmful effect of hyperglycemia on the myocardium even in individuals under the threshold for the diagnosis of diabetes mellitus. (diabetesincontrol.com)
  • This guideline offers best practice advice on the management of hyperglycaemia in all adults admitted to hospital for an acute coronary syndrome regardless of whether or not they have a diagnosis of diabetes. (nice.org.uk)
  • The clinical history of poor glycemic control, dysmetria and coordination loss within the left upper extremity together with the characteristic imaging findings of contralateral basal ganglia hyperdensity on CT and hyperintensity on T1-weighted imaging are characteristic for the diagnosis of nonketotic hyperglycemia-induced hemichorea-hemiballism (NKHH). (appliedradiology.com)
  • The term 'incidence' of Hyperglycemia refers to the annual diagnosis rate, or the number of new cases of Hyperglycemia diagnosed each year. (cureresearch.com)
  • U ncontrolled hyperglycemia in hospitalized patients with or without a previous diagnosis of diabetes is associated with adverse outcomes and longer lengths of stay. (diabetesjournals.org)
  • Chronic hyperglycemia at above normal levels can produce a very wide variety of serious complications over a period of years, including kidney damage, neurological damage, cardiovascular damage, damage to the retina or damage to feet and legs. (wikipedia.org)
  • Impairment of growth and susceptibility to certain infection can occur as a result of chronic hyperglycemia. (wikipedia.org)
  • Diabetes is a chronic metabolic disorder with hyperglycemia, gradually rising levels of glucose, as its primary characteristic. (encyclopedia.com)
  • Chronic hyperglycemia that persists even in fasting states is most commonly caused by diabetes mellitus , and in fact chronic hyperglycemia is the defining characteristic of the disease. (bionity.com)
  • Chronic hyperglycemia can be measured via the HbA1c test. (bionity.com)
  • Similar laboratory findings suggest a common effect of acute vs. chronic hyperglycemia on the coagulation system. (nih.gov)
  • In addition, both chronic and acute hyperglycemia are often accompanied by hyperinsulinemia, which has been shown to have prothrombotic effects as well. (nih.gov)
  • In conclusion, the laboratory evidence of the effects of both chronic and acute hyperglycemia suggests a prothrombotic shift. (nih.gov)
  • Instead, hyperglycemia may happen over a longer period of time and be caused by a chronic disease. (drugs.com)
  • This form of hyperglycemia is caused by low insulin levels. (bionity.com)
  • And because carbs convert to glucose in the blood, "inactivity coupled with an excessive intake of carbohydrates can increase blood glucose levels and lead to hyperglycemia," Palinski-Wade says. (rd.com)
  • Although there are other things that can lead to hyperglycemia, the most common cause is diabetes. (akronchildrens.org)
  • The underlying cause of hyperglycemia will usually be from loss of insulin producing cells in the pancreas or if the body develops resistance to insulin. (diabetes.co.uk)
  • 5,6 Although the data are limited, studies evaluating the effect of hyperglycemia on immune function consistently show that improving glycemic control improves immune function. (uspharmacist.com)
  • To the editor: Matas and associates (1) describe the adverse effect of hyperglycemia on renal function. (annals.org)
  • 11,12 In addition, inflammation and endothelial-cell dysfunction caused by hyperglycemia in the setting of acute illness contribute to cardiovascular complications. (uspharmacist.com)
  • Hyperglycemia can be triggered by irregular self-administration of insulin, by insulin resistance or defective insulin response in the body, by stress or infection, and by the activation of certain autoimmune processes characteristic of type 1 diabetes. (encyclopedia.com)
  • Hyperglycemia (HG) and insulin resistance are the hallmarks of a profoundly altered metabolism in critical illness resulting from the release of cortisol, catecholamines, and cytokines, as well as glucagon and growth hormone. (hindawi.com)
  • Multiple clinical risk factors and measures associated with insulin resistance, such as hyperglycemia, were assessed. (dovepress.com)
  • 17,18 Published studies evaluating outcomes with respect to hyperglycemia and stroke in humans for the most part have been retrospective or observational, but they also have shown worse outcomes. (uspharmacist.com)
  • Among adults without diabetes, hyperglycemia at hospital admission for acute myocardial infarction significantly increases the risk for all-cause mortality, and hyperglycemia is an independent predictor for morality, according to study data. (healio.com)
  • The complications of diabetes are often the effects of prolonged hyperglycemia. (medicalnewstoday.com)
  • Drinking more water treats hyperglycemia by removing excess blood sugar through the urine. (reference.com)
  • Successful hyperglycemia management can prevent the body from going into diabetic shock or developing ketones in the urine. (wisegeek.com)
  • When hyperglycemia is associated with the presence of ketones in the urine, this state demands immediate medical attention. (emedicinehealth.com)
  • Antisense oligonucleotide-induced loss of HMGCS2 in chow-fed adult mice caused mild hyperglycemia, increased hepatic gluconeogenesis from pyruvate, and augmented production of hundreds of hepatic metabolites, a suite of which indicated activation of the de novo lipogenesis pathway. (jci.org)
  • Moreover, even mild hyperglycemia (a fasting blood sugar over 109 mg/dL in adolescents/adults or over 100 mg/dL in children before puberty ) - when unrecognized or inadequately treated for several years - can damage multiple tissues in the brain, kidneys, and arteries. (emedicinehealth.com)
  • It's important to treat hyperglycemia, because if left untreated, hyperglycemia can become severe and lead to serious complications requiring emergency care, such as a diabetic coma. (mayoclinic.org)
  • It is important to treat hyperglycemia to prevent these problems. (drugs.com)
  • Scheduled basal/bolus insulin is designed to prevent hyperglycemia, whereas correction scale insulin only attempts to lower hyperglycemia after it has occurred. (diabetesjournals.org)
  • Levels higher than these might indicate hyperglycemia. (chemocare.com)
  • We could have a symptom which could indicate hyperglycemia, but it could equally indicate the onset of a cold, or kidney disease, or a urinary infection, or. (wizzley.com)
  • The HbA1c test can show if someone has been having significant hyperglycemia over time, even though the person may not have had obvious symptoms. (kidshealth.org)
  • 1 It is estimated that one-third of hospitalized patients will experience significant hyperglycemia. (diabetesjournals.org)
  • Epidemiological studies and preliminary intervention studies have shown that postprandial hyperglycemia is a direct and independent risk factor for cardiovascular disease (CVD). (diabetesjournals.org)
  • This alarmingly suggestive body of evidence for a harmful effect of postprandial hyperglycemia on diabetes complications has been sufficient to influence guidelines from key professional scientific societies. (diabetesjournals.org)
  • Correcting the postprandial hyperglycemia may form part of the strategy for the prevention and management of CVDs in diabetes. (diabetesjournals.org)
  • In this article, epidemiological data and preliminary results of intervention studies indicating that postprandial hyperglycemia represents an increased risk for CVD are surveyed and the proposed mechanisms involved in this effect are summarized. (diabetesjournals.org)
  • In addition to fasting glycemia and HbA 1c , emphasis has recently been given to the relationship between postprandial hyperglycemia and CVDs. (diabetesjournals.org)
  • Postprandial hyperglycemia and CVD: epidemiological evidences. (diabetesjournals.org)
  • Our study suggests that perioperative hyperglycemia was associated with new onset of postoperative neurocognitive disorders in adult patients after cardiac surgery, and that men tended to be protected from these outcomes. (dovepress.com)
  • Stress hyperglycemia (also called stress diabetes or diabetes of injury) is a medical term referring to transient elevation of the blood glucose due to the stress of illness. (wikipedia.org)
  • Stress hyperglycemia is especially common in patients with hypertonic dehydration and those with elevated catecholamine levels (e.g., after emergency department treatment of acute asthma with epinephrine). (wikipedia.org)
  • Steroid diabetes is a specific and prolonged form of stress hyperglycemia. (wikipedia.org)
  • Diagnosing patient can be complex, as there are no guidelines that specifically define stress hyperglycemia. (wikipedia.org)
  • One of the most sweeping changes in intensive care unit (ICU) and post-surgical care in recent years is the trend toward more aggressive treatment of stress-induced hyperglycemia. (wikipedia.org)
  • The NICE-SUGAR trial may very well change our approach to the management of stress-induced hyperglycemia in the ICU. (wikipedia.org)
  • Although A1c data weren't analyzed, the population is believed to include both individuals with pre-existing but undiagnosed diabetes and those without diabetes who have acute "stress hyperglycemia. (medscape.com)
  • Interestingly, stress induced hyperglycemia, which is often transient, has also been associated with poor outcome in thrombotic disease. (nih.gov)
  • Illness and stress also bump up blood sugar levels and can cause hyperglycemia. (rd.com)
  • Managing hyperglycemia in the acute care setting may be more difficult because of concurrent illnesses, stress, medication-regimen alterations, and changes in dietary intake. (uspharmacist.com)
  • In addition to the increasing prevalence of diabetes in the United States, many patients without preexisting diabetes experience stress-related hyperglycemia during hospitalization. (diabetesjournals.org)
  • An A1C value ≥ 6.5% can now be used for diagnosing diabetes and is valuable in distinguishing between preexisting diabetes and acute stress hyperglycemia. (diabetesjournals.org)
  • These results indicate that our study included both undiagnosed diabetic patients and nondiabetic patients with hyperglycemia caused by an acute blood-glucose disorder," the authors note. (medscape.com)
  • Patients with type 1 DM can have coexisting illnesses that aggravate hyperglycemia, such as infection, coronary artery disease (CAD), or fever. (medscape.com)
  • The cases of three patients with focal seizure associated to non-cetotic hyperglycemia are reported. (scielo.br)
  • Epilepsia partialis continua associated with nonketotic hyperglycemia : clinical and biochemical profile of 21 patients. (scielo.br)
  • The Stroke Hyperglycemia Insulin Network Effort (SHINE) Trial is a multicenter, randomized, controlled clinical trial of 1400 patients that will include approximately 60 enrolling sites. (clinicaltrials.gov)
  • The American Diabetes Association (ADA) and the European Association of the Study of Diabetes (EASD) got together in Berlin in the first week of October at EASD's 2018 annual meeting to present their new patient-centered hyperglycemia guidelines for treating hyperglycemia in patients who have type 2 diabetes. (diabetesincontrol.com)
  • 4 Much of the information regarding how acute hyperglycemia contributes to complications in hospitalized patients--such as increased rates of infection and thrombosis, impaired wound healing, and impaired cardiac function--is limited, but it provides important direction for future research and treatment. (uspharmacist.com)
  • 15 Increased von Willebrand factor activity and thromboxane A 2 production occur during episodes of hyperglycemia and may contribute to the increased risk of clot formation seen in hospitalized patients with hyperglycemia. (uspharmacist.com)
  • 15 These findings may explain the mechanism by which patients with hyperglycemia experience increased rates of thrombosis. (uspharmacist.com)
  • Although no studies have been conducted evaluating the impact of hyperglycemia in critically ill patients from the short-term use of atypical antipsychotics for the treatment of delirium, the potential to affect clinical outcomes exist and warrants further research in this area. (springer.com)
  • For most patients, hyperglycemia or diabetes resolved after stopping the protease inhibitor, however these events did not resolve in some patients. (nih.gov)
  • Another top story was about data that indicated treating hyperglycemia lowered the odds of COVID-19 mortality in non-ICU patients. (healio.com)
  • Although hyperglycemia, which is seen in 78% of hospitalized patients with diabetes and 26% of those without, is linked to mortality regardless of diabetic status, mortality is greater in patients with diabetes, especially in those newly diagnosed with hyperglycemia, Dr. Hirsch said. (the-hospitalist.org)
  • Enter the patient's measured sodium level and serum glucose in the hyperglycemia sodium correction calculator to find the correct sodium levels for hyperglycemia patients. (easycalculation.com)
  • In transplant patients, tacrolimus is more likely to result in hyperglycemia, especially in pediatric transplant recipients and African Americans, and is estimated to be 5 times as diabetogenic as cyclosporine. (oncologynurseadvisor.com)
  • In both transplant and oncology patients, GCs, in addition to either L-asparaginase or tacrolimus, has resulted in significantly higher rates of hyperglycemia than seen with any of the agents alone. (oncologynurseadvisor.com)
  • In patients with ALL , increased risk of infections is seen with hyperglycemia, and infection can be an initial presentation of hyperglycemia. (oncologynurseadvisor.com)
  • Patients may be at risk for autoimmune disease, such as type 1 diabetes, which can make the distinction between type 1 diabetes and drug-induced hyperglycemia difficult. (oncologynurseadvisor.com)
  • Control of hyperglycemia in hospitalized patients is important for optimal clinical outcomes, but can be very challenging. (diabetesjournals.org)
  • Patients with diabetes or hyperglycemia who are eating should be on a consistent-carbohydrate diet, and glucose monitoring should be ordered before each meal and at bedtime. (diabetesjournals.org)
  • Nondiabetic maternal hyperglycemia was associated with adverse pregnancy outcomes. (nih.gov)
  • Also, life-threatening consequences of hyperglycemia is nonketotic hyperosmolar syndrome. (wikipedia.org)
  • Extreme hyperglycemia and hyperosmolar hyperglycemic syndrom. (lww.com)
  • Occasional episodes of hyperglycaemia can also occur in children and young adults during growth spurts. (www.nhs.uk)
  • If you have frequent episodes of hyperglycemia, your doctor may adjust the dosage or timing of your medication. (mayoclinic.org)
  • Recognizing early signs and symptoms of hyperglycemia can help you treat the condition promptly. (mayoclinic.org)
  • What are the telling signs that you have hyperglycemia? (starmometer.com)
  • Hyperglycemia increases the risk of vascular complications such as diabetic retinopathy, diabetic nephropathy, peripheral vascular disease and cerebro/cardiovascular diseases. (mdpi.com)
  • 1. Askenasy JJ, Streifler M, Carrasco R. Moderate nonketotic hyperglycemia : a cause of focal epilepsy. (scielo.br)
  • Nonketotic hyperglycemia and epilepsia partialis continua. (scielo.br)
  • Tonic focal seizures in nonketotic hyperglycemia of diabetes mellitus Arch Neurol 1981, 38:512-514. (scielo.br)
  • 1 Though basal ganglia infarction accounts for most cases, uncontrolled and prolonged hyperglycemia now represents the second-most common etiology, designated by the clinical acronyms NKHH (nonketotic hemichorea-hemiballism) or HIHH (hyperglycemia-induced hemichorea-hemiballism). (appliedradiology.com)
  • In this study, we investigated the miRNA expression changes in human umbilical vein endothelial cells exposed to different glucose concentrations (5, 10, 25 and 40 mM glucose) and at various time intervals (6, 12, 24 and 48 h). miRNA microarray analyses showed that there is a correlation between hyperglycemia induced endothelial dysfunction and miRNA expression. (mdpi.com)
  • Induction of hyperglycemia gives rise to cardiac apoptosis and dysfunction in adult zebrafish via the Nkx2.5-Calr-p53 signaling pathway, resulting in adult cardiomyopathy. (biologists.org)
  • Hyperglycemia is believed to induce coronary microvascular dysfunction and result in myocardial injury. (diabetesincontrol.com)
  • For your child, hyperglycemia is a blood sugar level that is above their target range. (umassmed.edu)
  • If you work to keep your blood sugar under control -- follow your meal plan, exercise program , and medicine schedule -- you shouldn't have to worry about hyperglycemia. (webmd.com)
  • Hyperglycemia is a condition when a person has increased levels of blood sugar and is usually the first sign of diabetes. (heart.org)
  • Hyperglycaemia should not be confused with hypoglycaemia , which is when a person's blood sugar level drops too low. (www.nhs.uk)
  • If you have been diagnosed with diabetes and have symptoms of hyperglycaemia, follow the advice your care team has given you to reduce your blood sugar level. (www.nhs.uk)
  • But even non-diabetics can be susceptible to blood sugar extremes, called hyperglycemia and hypoglycemia. (rd.com)
  • As discussed, certain conditions may cause temporary increases in blood sugar levels, resulting in hyperglycemia. (chemocare.com)
  • One of the most important methods for hyperglycemia management is checking blood sugar levels often so that they are always within an acceptable range. (wisegeek.com)
  • Regular blood sugar checks are crucial in proper hyperglycemia management since they can result in early treatment of this condition. (wisegeek.com)
  • The diabetes center: introduction to diabetes symptoms, Diabetes is a disorder characterized by hyperglycemia or elevated blood glucose (blood sugar). (amazonaws.com)
  • Hyperglycemia should not be confused with hypoglycemia , which is when blood sugar levels go too low. (diabetes.co.uk)
  • Testing blood sugar levels will help in managing hyperglycemia. (diabetes.co.uk)
  • If you have diabetes, or otherwise suffer from hypoglycemia or hyperglycemia, it is imperative you keep your blood sugar under control as much as possible. (brainandspinalcord.org)
  • Hyperglycemia reduces proteoglycan levels in tendons. (nih.gov)
  • Hyperglycemia produces a reduction in PG levels related to decreased synthesis or sulfation of glycosaminoglycans, which may contribute to the tendon pathology observed clinically in diabetes. (nih.gov)
  • If you don't manage your blood glucose levels and you are diabetic, it can result in hyperglycaemia. (gulfnews.com)
  • You may also have an infection in your pancreas that controls blood insulin levels , thus resulting in hyperglycemia. (chemocare.com)
  • This is an example of the importance of regularly checking blood glucose levels to practice hyperglycemia management. (wisegeek.com)
  • Most people suffering from hyperglycemia need to ensure that they do not eat too much, but they still need to eat regularly to keep levels balanced. (wisegeek.com)
  • Hyperglycemia mean higher than normal (hyper) levels of glucose (sugar) in the blood. (nih.gov)
  • In the inpatient setting, random hyperglycemia is often discovered when glucose levels are measured in conjunction with routine labs and the classic symptoms above are not noted. (oncologynurseadvisor.com)
  • A MEDLINE search for acute hyperglycemia from short-term use of antipsychotics resulted in studies involving animal models and healthy volunteers. (springer.com)
  • Many young type 2 diabetics do not have symptoms because their hyperglycemia is moderate compared to type 1 diabetics, and they are not taking insulin. (encyclopedia.com)
  • Treatment options for hyperglycemia include making dietary changes, drinking more water, switching medications and possibly exercising, according to WebMD. (reference.com)
  • If you or someone you love has developed Hypoglycemia or Hyperglycemia while using prescription medications, we can help you explore your legal options. (consumerinjurylawyers.com)
  • Acute illness, inconsistent caloric intake, changes from home medications, and limitations regarding the timing of glucose monitoring and insulin administration are all significant obstacles to managing inpatient hyperglycemia. (diabetesjournals.org)
  • Prevention of hyperglycemia contributes to inhibit the onset of these life-related diseases. (go.jp)
  • Hyperglycemia and adverse pregnancy outcomes. (nih.gov)
  • It is controversial whether maternal hyperglycemia less severe than that in diabetes mellitus is associated with increased risks of adverse pregnancy outcomes. (nih.gov)
  • Non-diabetic maternal hyperglycaemia was associated with adverse pregnancy outcomes. (nih.gov)
  • OBJECTIVE To compare associations of maternal glucose and A1C with adverse outcomes in the multinational Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study and determine, based on those comparisons, if A1C measurement can provide an alternative to an oral glucose tolerance test (OGTT) in pregnant women. (diabetesjournals.org)
  • The objective of the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study was to clarify the risk of adverse outcomes associated with degrees of glucose intolerance in pregnancy less severe than overt diabetes. (diabetesjournals.org)
  • 16 Animal studies have found that outcomes are worse in acute brain ischemia when hyperglycemia is present. (uspharmacist.com)