Hyperalgesia. Medical search

An increased sensation of pain or discomfort produced by mimimally noxious stimuli due to damage to soft tissue containing NOCICEPTORS or injury to a peripheral nerve.

Amount of stimulation required before the sensation of pain is experienced.

Peripheral AFFERENT NEURONS which are sensitive to injuries or pain, usually caused by extreme thermal exposures, mechanical forces, or other noxious stimuli. Their cell bodies reside in the DORSAL ROOT GANGLIA. Their peripheral terminals (NERVE ENDINGS) innervate target tissues and transduce noxious stimuli via axons to the CENTRAL NERVOUS SYSTEM.

Scales, questionnaires, tests, and other methods used to assess pain severity and duration in patients or experimental animals to aid in diagnosis, therapy, and physiological studies.

A water-soluble extractive mixture of sulfated polysaccharides from RED ALGAE. Chief sources are the Irish moss CHONDRUS CRISPUS (Carrageen), and Gigartina stellata. It is used as a stabilizer, for suspending COCOA in chocolate manufacture, and to clarify BEVERAGES.

An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.

Introduction of therapeutic agents into the spinal region using a needle and syringe.

Act of eliciting a response from a person or organism through physical contact.

Compounds capable of relieving pain without the loss of CONSCIOUSNESS.

A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.

An alkylamide found in CAPSICUM that acts at TRPV CATION CHANNELS.

An antigen solution emulsified in mineral oil. The complete form is made up of killed, dried mycobacteria, usually M. tuberculosis, suspended in the oil phase. It is effective in stimulating cell-mediated immunity (IMMUNITY, CELLULAR) and potentiates the production of certain IMMUNOGLOBULINS in some animals. The incomplete form does not contain mycobacteria.

Presence of warmth or heat or a temperature notably higher than an accustomed norm.

Intense or aching pain that occurs along the course or distribution of a peripheral or cranial nerve.

A cylindrical column of tissue that lies within the vertebral canal. It is composed of WHITE MATTER and GRAY MATTER.

Sensory ganglia located on the dorsal spinal roots within the vertebral column. The spinal ganglion cells are pseudounipolar. The single primary branch bifurcates sending a peripheral process to carry sensory information from the periphery and a central branch which relays that information to the spinal cord or brain.

A subgroup of TRP cation channels named after vanilloid receptor. They are very sensitive to TEMPERATURE and hot spicy food and CAPSAICIN. They have the TRP domain and ANKYRIN repeats. Selectivity for CALCIUM over SODIUM ranges from 3 to 100 fold.

Compounds with activity like OPIATE ALKALOIDS, acting at OPIOID RECEPTORS. Properties include induction of ANALGESIA or NARCOSIS.

Sensation of making physical contact with objects, animate or inanimate. Tactile stimuli are detected by MECHANORECEPTORS in the skin and mucous membranes.

Neurons in the SPINAL CORD DORSAL HORN whose cell bodies and processes are confined entirely to the CENTRAL NERVOUS SYSTEM. They receive collateral or direct terminations of dorsal root fibers. They send their axons either directly to ANTERIOR HORN CELLS or to the WHITE MATTER ascending and descending longitudinal fibers.

The principal alkaloid in opium and the prototype opiate analgesic and narcotic. Morphine has widespread effects in the central nervous system and on smooth muscle.

Any of several BRASSICA species that are commonly called mustard. Brassica alba is white mustard, B. juncea is brown or Chinese mustard, and B. nigra is black, brown, or red mustard. The plant is grown both for mustard seed from which oil is extracted or used as SPICES, and for its greens used as VEGETABLES or ANIMAL FEED. There is no relationship to MUSTARD COMPOUNDS.

Disease or damage involving the SCIATIC NERVE, which divides into the PERONEAL NERVE and TIBIAL NERVE (see also PERONEAL NEUROPATHIES and TIBIAL NEUROPATHY). Clinical manifestations may include SCIATICA or pain localized to the hip, PARESIS or PARALYSIS of posterior thigh muscles and muscles innervated by the peroneal and tibial nerves, and sensory loss involving the lateral and posterior thigh, posterior and lateral leg, and sole of the foot. The sciatic nerve may be affected by trauma; ISCHEMIA; COLLAGEN DISEASES; and other conditions. (From Adams et al., Principles of Neurology, 6th ed, p1363)

Increased sensitivity to cutaneous stimulation due to a diminished threshold or an increased response to stimuli.

Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.

A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.

The observable response an animal makes to any situation.

Sensing of noxious mechanical, thermal or chemical stimuli by NOCICEPTORS. It is the sensory component of visceral and tissue pain (NOCICEPTIVE PAIN).

A type of pain that is perceived in an area away from the site where the pain arises, such as facial pain caused by lesion of the VAGUS NERVE, or throat problem generating referred pain in the ear.

The 31 paired peripheral nerves formed by the union of the dorsal and ventral spinal roots from each spinal cord segment. The spinal nerve plexuses and the spinal roots are also included.

Specialized afferent neurons capable of transducing sensory stimuli into NERVE IMPULSES to be transmitted to the CENTRAL NERVOUS SYSTEM. Sometimes sensory receptors for external stimuli are called exteroceptors; for internal stimuli are called interoceptors and proprioceptors.

Progressive diminution of the susceptibility of a human or animal to the effects of a drug, resulting from its continued administration. It should be differentiated from DRUG RESISTANCE wherein an organism, disease, or tissue fails to respond to the intended effectiveness of a chemical or drug. It should also be differentiated from MAXIMUM TOLERATED DOSE and NO-OBSERVED-ADVERSE-EFFECT LEVEL.

Pain originating from internal organs (VISCERA) associated with autonomic phenomena (PALLOR; SWEATING; NAUSEA; and VOMITING). It often becomes a REFERRED PAIN.

A nerve which originates in the lumbar and sacral spinal cord (L4 to S3) and supplies motor and sensory innervation to the lower extremity. The sciatic nerve, which is the main continuation of the sacral plexus, is the largest nerve in the body. It has two major branches, the TIBIAL NERVE and the PERONEAL NERVE.

The distal extremity of the leg in vertebrates, consisting of the tarsus (ANKLE); METATARSUS; phalanges; and the soft tissues surrounding these bones.

Abnormal fluid accumulation in TISSUES or body cavities. Most cases of edema are present under the SKIN in SUBCUTANEOUS TISSUE.

A class of nerve fibers as defined by their nerve sheath arrangement. The AXONS of the unmyelinated nerve fibers are small in diameter and usually several are surrounded by a single MYELIN SHEATH. They conduct low-velocity impulses, and represent the majority of peripheral sensory and autonomic fibers, but are also found in the BRAIN and SPINAL CORD.

Contractions of the abdominal muscles upon stimulation of the skin (superficial abdominal reflex) or tapping neighboring bony structures (deep abdominal reflex). The superficial reflex may be weak or absent, for example, after a stroke, a sign of upper (suprasegmental) motor neuron lesions. (Stedman, 25th ed & Best & Taylor's Physiological Basis of Medical Practice, 12th ed, p1073)

Diseases of the peripheral nerves external to the brain and spinal cord, which includes diseases of the nerve roots, ganglia, plexi, autonomic nerves, sensory nerves, and motor nerves.

Methods of PAIN relief that may be used with or in place of ANALGESICS.

Neurons which conduct NERVE IMPULSES to the CENTRAL NERVOUS SYSTEM.

Drugs that act on neuronal sensory receptors resulting in an increase, decrease, or modification of afferent nerve activity. (From Smith and Reynard, Textbook of Pharmacology, 1991, p367)

Either of two extremities of four-footed non-primate land animals. It usually consists of a FEMUR; TIBIA; and FIBULA; tarsals; METATARSALS; and TOES. (From Storer et al., General Zoology, 6th ed, p73)

A subclass of analgesic agents that typically do not bind to OPIOID RECEPTORS and are not addictive. Many non-narcotic analgesics are offered as NONPRESCRIPTION DRUGS.

The sensory fibers innervating the viscera.

A class of cell surface receptors for TACHYKININS with a preference for SUBSTANCE P. Neurokinin-1 (NK-1) receptors have been cloned and are members of the G protein coupled receptor superfamily. They are found on many cell types including central and peripheral neurons, smooth muscle cells, acinar cells, endothelial cells, fibroblasts, and immune cells.

The relationship between the dose of an administered drug and the response of the organism to the drug.

A class of ionotropic glutamate receptors characterized by affinity for N-methyl-D-aspartate. NMDA receptors have an allosteric binding site for glycine which must be occupied for the channel to open efficiently and a site within the channel itself to which magnesium ions bind in a voltage-dependent manner. The positive voltage dependence of channel conductance and the high permeability of the conducting channel to calcium ions (as well as to monovalent cations) are important in excitotoxicity and neuronal plasticity.

A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain.

The forcing into the skin of liquid medication, nutrient, or other fluid through a hollow needle, piercing the top skin layer.

An eleven-amino acid neurotransmitter that appears in both the central and peripheral nervous systems. It is involved in transmission of PAIN, causes rapid contractions of the gastrointestinal smooth muscle, and modulates inflammatory and immune responses.

A cyclohexanone derivative used for induction of anesthesia. Its mechanism of action is not well understood, but ketamine can block NMDA receptors (RECEPTORS, N-METHYL-D-ASPARTATE) and may interact with sigma receptors.

Any of the large interior organs in any one of the three great cavities of the body, especially in the abdomen.

Agents inhibiting the effect of narcotics on the central nervous system.

The most common and most biologically active of the mammalian prostaglandins. It exhibits most biological activities characteristic of prostaglandins and has been used extensively as an oxytocic agent. The compound also displays a protective effect on the intestinal mucosa.

A specific opiate antagonist that has no agonist activity. It is a competitive antagonist at mu, delta, and kappa opioid receptors.

NERVE GROWTH FACTOR is the first of a series of neurotrophic factors that were found to influence the growth and differentiation of sympathetic and sensory neurons. It is comprised of alpha, beta, and gamma subunits. The beta subunit is responsible for its growth stimulating activity.

A highly reactive aldehyde gas formed by oxidation or incomplete combustion of hydrocarbons. In solution, it has a wide range of uses: in the manufacture of resins and textiles, as a disinfectant, and as a laboratory fixative or preservative. Formaldehyde solution (formalin) is considered a hazardous compound, and its vapor toxic. (From Reynolds, Martindale The Extra Pharmacopoeia, 30th ed, p717)

The caudal portion of the nucleus of the spinal trigeminal tract (TRIGEMINAL NUCLEUS, SPINAL), a nucleus involved with pain and temperature sensation.

Compounds that inhibit or block the activity of NEUROKININ-1 RECEPTORS.

The lower portion of the BRAIN STEM. It is inferior to the PONS and anterior to the CEREBELLUM. Medulla oblongata serves as a relay station between the brain and the spinal cord, and contains centers for regulating respiratory, vasomotor, cardiac, and reflex activities.

Injuries to the PERIPHERAL NERVES.

Disease or trauma involving a single peripheral nerve in isolation, or out of proportion to evidence of diffuse peripheral nerve dysfunction. Mononeuropathy multiplex refers to a condition characterized by multiple isolated nerve injuries. Mononeuropathies may result from a wide variety of causes, including ISCHEMIA; traumatic injury; compression; CONNECTIVE TISSUE DISEASES; CUMULATIVE TRAUMA DISORDERS; and other conditions.

A group of compounds derived from ammonia by substituting organic radicals for the hydrogens. (From Grant & Hackh's Chemical Dictionary, 5th ed)

The endogenous peptides with opiate-like activity. The three major classes currently recognized are the ENKEPHALINS, the DYNORPHINS, and the ENDORPHINS. Each of these families derives from different precursors, proenkephalin, prodynorphin, and PRO-OPIOMELANOCORTIN, respectively. There are also at least three classes of OPIOID RECEPTORS, but the peptide families do not map to the receptors in a simple way.

A class of opioid receptors recognized by its pharmacological profile. Mu opioid receptors bind, in decreasing order of affinity, endorphins, dynorphins, met-enkephalin, and leu-enkephalin. They have also been shown to be molecular receptors for morphine.

A family of hexahydropyridines.

Mechanical compression of nerves or nerve roots from internal or external causes. These may result in a conduction block to nerve impulses (due to MYELIN SHEATH dysfunction) or axonal loss. The nerve and nerve sheath injuries may be caused by ISCHEMIA; INFLAMMATION; or a direct mechanical effect.

Pain during the period after surgery.

Pain in the facial region including orofacial pain and craniofacial pain. Associated conditions include local inflammatory and neoplastic disorders and neuralgic syndromes involving the trigeminal, facial, and glossopharyngeal nerves. Conditions which feature recurrent or persistent facial pain as the primary manifestation of disease are referred to as FACIAL PAIN SYNDROMES.

A local anesthetic and cardiac depressant used as an antiarrhythmia agent. Its actions are more intense and its effects more prolonged than those of PROCAINE but its duration of action is shorter than that of BUPIVACAINE or PRILOCAINE.

Calcitonin gene-related peptide. A 37-amino acid peptide derived from the calcitonin gene. It occurs as a result of alternative processing of mRNA from the calcitonin gene. The neuropeptide is widely distributed in neural tissue of the brain, gut, perivascular nerves, and other tissue. The peptide produces multiple biological effects and has both circulatory and neurotransmitter modes of action. In particular, it is a potent endogenous vasodilator.

A condition where damage to the peripheral nervous system (including the peripheral elements of the autonomic nervous system) is associated with chronic ingestion of alcoholic beverages. The disorder may be caused by a direct effect of alcohol, an associated nutritional deficiency, or a combination of factors. Clinical manifestations include variable degrees of weakness; ATROPHY; PARESTHESIAS; pain; loss of reflexes; sensory loss; diaphoresis; and postural hypotension. (From Arch Neurol 1995;52(1):45-51; Adams et al., Principles of Neurology, 6th ed, p1146)

Peripheral, autonomic, and cranial nerve disorders that are associated with DIABETES MELLITUS. These conditions usually result from diabetic microvascular injury involving small blood vessels that supply nerves (VASA NERVORUM). Relatively common conditions which may be associated with diabetic neuropathy include third nerve palsy (see OCULOMOTOR NERVE DISEASES); MONONEUROPATHY; mononeuropathy multiplex; diabetic amyotrophy; a painful POLYNEUROPATHY; autonomic neuropathy; and thoracoabdominal neuropathy. (From Adams et al., Principles of Neurology, 6th ed, p1325)

A potent noncompetitive antagonist of the NMDA receptor (RECEPTORS, N-METHYL-D-ASPARTATE) used mainly as a research tool. The drug has been considered for the wide variety of neurodegenerative conditions or disorders in which NMDA receptors may play an important role. Its use has been primarily limited to animal and tissue experiments because of its psychotropic effects.

A G-protein-coupled, proteinase-activated receptor that is expressed in a variety of tissues including ENDOTHELIUM; LEUKOCYTES; and the GASTROINTESTINAL TRACT. The receptor is activated by TRYPSIN, which cleaves off the N-terminal peptide from the receptor. The new N-terminal peptide is a cryptic ligand for the receptor. The uncleaved receptor can also be activated by the N-terminal peptide present on the activated THROMBIN RECEPTOR and by small synthetic peptides that contain the unmasked N-terminal sequence.

A form of acupuncture with electrical impulses passing through the needles to stimulate NERVE TISSUE. It can be used for ANALGESIA; ANESTHESIA; REHABILITATION; and treatment for diseases.

Painful sensation in the muscles.

Drugs that bind to but do not activate excitatory amino acid receptors, thereby blocking the actions of agonists.

A class of opioid peptides including dynorphin A, dynorphin B, and smaller fragments of these peptides. Dynorphins prefer kappa-opioid receptors (RECEPTORS, OPIOID, KAPPA) and have been shown to play a role as central nervous system transmitters.

A protein kinase C subtype that was originally characterized as a CALCIUM-independent, serine-threonine kinase that is activated by PHORBOL ESTERS and DIACYLGLYCEROLS. It is targeted to specific cellular compartments in response to extracellular signals that activate G-PROTEIN-COUPLED RECEPTORS; TYROSINE KINASE RECEPTORS; and intracellular protein tyrosine kinase.

Cell membrane proteins that bind opioids and trigger intracellular changes which influence the behavior of cells. The endogenous ligands for opioid receptors in mammals include three families of peptides, the enkephalins, endorphins, and dynorphins. The receptor classes include mu, delta, and kappa receptors. Sigma receptors bind several psychoactive substances, including certain opioids, but their endogenous ligands are not known.

A broad group of eukaryotic six-transmembrane cation channels that are classified by sequence homology because their functional involvement with SENSATION is varied. They have only weak voltage sensitivity and ion selectivity. They are named after a DROSOPHILA mutant that displayed transient receptor potentials in response to light. A 25-amino-acid motif containing a TRP box (EWKFAR) just C-terminal to S6 is found in TRPC, TRPV and TRPM subgroups. ANKYRIN repeats are found in TRPC, TRPV & TRPN subgroups. Some are functionally associated with TYROSINE KINASE or TYPE C PHOSPHOLIPASES.

A family of proton-gated sodium channels that are primarily expressed in neuronal tissue. They are AMILORIDE-sensitive and are implicated in the signaling of a variety of neurological stimuli, most notably that of pain in response to acidic conditions.

Aching sensation that persists for more than a few months. It may or may not be associated with trauma or disease, and may persist after the initial injury has healed. Its localization, character, and timing are more vague than with acute pain.

A nonapeptide messenger that is enzymatically produced from KALLIDIN in the blood where it is a potent but short-lived agent of arteriolar dilation and increased capillary permeability. Bradykinin is also released from MAST CELLS during asthma attacks, from gut walls as a gastrointestinal vasodilator, from damaged tissues as a pain signal, and may be a neurotransmitter.

The time from the onset of a stimulus until a response is observed.

Dull or sharp aching pain caused by stimulated NOCICEPTORS due to tissue injury, inflammation or diseases. It can be divided into somatic or tissue pain and VISCERAL PAIN.

Surgical interruption of a spinal or cranial nerve root. (From Dorland, 28th ed)

A statistical technique that isolates and assesses the contributions of categorical independent variables to variation in the mean of a continuous dependent variable.

Drugs that block nerve conduction when applied locally to nerve tissue in appropriate concentrations. They act on any part of the nervous system and on every type of nerve fiber. In contact with a nerve trunk, these anesthetics can cause both sensory and motor paralysis in the innervated area. Their action is completely reversible. (From Gilman AG, et. al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed) Nearly all local anesthetics act by reducing the tendency of voltage-dependent sodium channels to activate.

Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions.They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects.

Elements of limited time intervals, contributing to particular results or situations.

Traumatic injuries to the TRIGEMINAL NERVE. It may result in extreme pain, abnormal sensation in the areas the nerve innervates on face, jaw, gums and tongue and can cause difficulties with speech and chewing. It is sometimes associated with various dental treatments.

A TETRACYCLINE analog, having a 7-dimethylamino and lacking the 5 methyl and hydroxyl groups, which is effective against tetracycline-resistant STAPHYLOCOCCUS infections.

Absent or reduced sensitivity to cutaneous stimulation.

Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters. Amitriptyline also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines.

Region of the back including the LUMBAR VERTEBRAE, SACRUM, and nearby structures.

An eph family receptor found primarily in the nervous system. In the embryonic BRAIN EphB1 receptor expression occurs in the mantle layer and increases with the progression of embryogenesis. In adult brain it is found in the several regions including the CEREBELLUM; CEREBRAL CORTEX; and CAUDATE NUCLEUS; and PUTAMEN.

Cardiovascular and neuronal responses to head stimulation reflect central sensitization and cutaneous allodynia in a rat model of migraine. (1/2095)

Reduction of the threshold of cardiovascular and neuronal responses to facial and intracranial stimulation reflects central sensitization and cutaneous allodynia in a rat model of migraine. Current theories propose that migraine pain is caused by chemical activation of meningeal perivascular fibers. We previously found that chemical irritation of the dura causes trigeminovascular fibers innervating the dura and central trigeminal neurons receiving convergent input from the dura and skin to respond to low-intensity mechanical and thermal stimuli that previously induced minimal or no responses. One conclusion of these studies was that when low- and high-intensity stimuli induce responses of similar magnitude in nociceptive neurons, low-intensity stimuli must be as painful as the high-intensity stimuli. The present study investigates in anesthetized rats the significance of the changes in the responses of central trigeminal neurons (i.e., in nucleus caudalis) by correlating them with the occurrence and type of the simultaneously recorded cardiovascular responses. Before chemical stimulation of the dura, simultaneous increases in neuronal firing rates and blood pressure were induced by dural indentation with forces >/= 2.35 g and by noxious cutaneous stimuli such as pinching the skin and warming > 46 degrees C. After chemical stimulation, similar neuronal responses and blood pressure increases were evoked by much smaller forces for dural indentation and by innocuous cutaneous stimuli such as brushing the skin and warming it to >/= 43 degrees C. The onsets of neuronal responses preceded the onsets of depressor responses by 1.7 s and pressor responses by 4.0 s. The duration of neuronal responses was 15 s, whereas the duration of depressor responses was shorter (5.8 s) and pressor responses longer (22.7 s) than the neuronal responses. We conclude that the facilitated cardiovascular and central trigeminal neuronal responses to innocuous stimulation of the skin indicate that when dural stimulation induces central sensitization, innocuous stimuli are as nociceptive as noxious stimuli had been before dural stimulation and that a similar process might occur during the development of cutaneous allodynia during migraine. (+info)

Cytokine-mediated inflammatory hyperalgesia limited by interleukin-4. (2/2095)

1. The effect of IL-4 on responses to intraplantar (i.pl.) carrageenin, bradykinin, TNFalpha, IL-1beta, IL-8 and PGE2 was investigated in a model of mechanical hyperalgesia in rats. Also, the cellular source of the IL-4 was investigated. 2. IL-4, 30 min before the stimulus, inhibited responses to carrageenin, bradykinin, and TNFalpha, but not responses to IL-1beta, IL-8 and PGE2. 3. IL-4, 2 h before the injection of IL-1beta, did not affect the response to IL-1beta, whereas IL-4, 12 or 12+2 h before the IL-1beta, inhibited the hyperalgesia (-30%, -74%, respectively). 4. In murine peritoneal macrophages, murine IL-4 for 2 h before stimulation with LPS, inhibited (-40%) the production of IL-1beta but not PGE2. Murine IL-4 (for 16 h before stimulation with LPS) inhibited LPS-stimulated PGE2 but not IL-1beta. 5. Anti-murine IL-4 antibodies potentiated responses to carrageenin, bradykinin and TNFalpha, but not IL-1beta and IL-8, as well as responses to bradykinin in athymic rats but not in rats depleted of mast cells with compound 40/80. 6. These data suggest that IL-4 released by mast cells limits inflammatory hyperalgesia. During the early phase of the inflammatory response the mode of action of the IL-4 appears to be inhibition of the production TNFalpha, IL-1beta and IL-8. In the later phase of the response, in addition to inhibiting the production of pro-inflammatory cytokines, IL-4 also may inhibit the release of PGs. (+info)

The effects of inflammation and inflammatory mediators on nociceptive behaviour induced by ATP analogues in the rat. (3/2095)

1. We have studied the behavioural effects of intraplantar injections of adenosine 5'-triphosphate (ATP) and related compounds in freely moving rats and investigated whether these nociceptive effects are augmented in the presence of inflammatory mediators. 2. We find that in normal animals ATP and analogues produce dose-dependent nocifensive behaviour (seen as bursts of elevation of the treated hindpaw), and localized thermal hyperalgesia. The rank order of potency was: alpha,beta-methyleneadenosine 5'-triphosphate (alpha,beta-methylene ATP) > 2-methylthioadenosine triphosphate (2-methylthio ATP) > ATP. After neonatal treatment with capsaicin, to destroy small calibre primary sensory neurones, nocifensive behaviour was largely absent. 3. The effects of ATP analogues were assessed in three models of peripheral sensitization: 2 h after dilute intraplantar carrageenan (0.25% w v(-1)); 24 h after irradiation of the hindpaw with ultraviolet (U.V.) B; immediately following prostaglandin E2 (PGE2) treatment. In all models the effect of alpha,beta-methylene ATP was greatly augmented. After carrageenan, significant hindpaw-lifting behaviour activity was induced by injection of only 0.05 nmol of alpha,beta-methylene ATP, some 100 times less than necessary in normal skin. 4. Our data suggest that it is much more likely that endogenous levels of ATP will reach levels capable of exciting nociceptors in inflamed versus normal skin. Our data also suggest the involvement of P2X3 receptor subunits in ATP-induced nociception. (+info)

Role of protein kinase A in the maintenance of inflammatory pain. (4/2095)

Although the initiation of inflammatory pain (hyperalgesia) has been demonstrated to require the cAMP second messenger signaling cascade, whether this mechanism and/or other mechanisms underlie the continued maintenance of the induced hyperalgesia is unknown. We report that injection of adenylyl cyclase inhibitors before but not after injection of direct-acting hyperalgesic agents (prostaglandin E2 and purine and serotonin receptor agonists) resulted in reduction in hyperalgesia, evaluated by the Randall-Selitto paw-withdrawal test. In contrast, injection of protein kinase A (PKA) inhibitors either before or after these hyperalgesic agents resulted in reduced hyperalgesia, suggesting that hyperalgesia after its activation was maintained by persistent PKA activity but not by adenylyl cyclase activity. To evaluate further the role of PKA activity in the maintenance of hyperalgesia, we injected the catalytic subunit of PKA (PKACS) that resulted in hyperalgesia similar in magnitude to that induced by the direct-acting hyperalgesic agents but much longer in duration (>48 vs 2 hr). Injection of WIPTIDE (a PKA inhibitor) at 24 hr after PKACS reduced hyperalgesia, suggesting that PKACS hyperalgesia is not independently maintained by steps downstream from PKA. In summary, our results indicate that, once established, inflammatory mediator-induced hyperalgesia is no longer maintained by adenylyl cyclase activity but rather is dependent on ongoing PKA activity. An understanding of the mechanism maintaining hyperalgesia may provide important insight into targets for the treatment of persistent pain. (+info)

Primary and secondary hyperalgesia in a rat model for human postoperative pain. (5/2095)

BACKGROUND: Previously, the authors developed and characterized a rat model for postoperative pain to learn more about pain produced by incisions. In this study, the responses to heat and mechanical stimuli were evaluated directly on or adjacent to the incision and at varying distances from the incision. METHODS: Rats were anesthetized with halothane and incisions were made at different locations in the plantar aspect of the foot. The response frequency to a blunt mechanical stimulus, the withdrawal threshold to von Frey filaments (15-522 mN), and the withdrawal latency to radiant heat were measured. Rats were tested before surgery, 2 h later, and then daily through postoperative day 9. RESULTS: After plantar incision, persistent hyperalgesia was observed immediately adjacent to or directly on the incision to punctate and blunt mechanical stimuli, respectively. The withdrawal threshold to punctate stimuli applied 1 cm from the incision was decreased through postoperative day 1. In a transitional area, between the distant and adjacent sites, the withdrawal threshold was intermediate and the duration of hyperalgesia was transient. Heat hyperalgesia was persistent but present when the stimulus was applied to the site of injury but not to a distant site. CONCLUSION: Robust primary hyperalgesia to punctate and blunt mechanical stimuli was present. Hyperalgesia distant to the wound, or secondary hyperalgesia, occurred in response to punctate mechanical stimuli, was short-lived, and required greater forces. These results suggest that the most persistent pain behaviors in this model are largely primary hyperalgesia. (+info)

The novel analgesic compound OT-7100 (5-n-butyl-7-(3,4,5-trimethoxybenzoylamino)pyrazolo[1,5-a]pyrimid ine) attenuates mechanical nociceptive responses in animal models of acute and peripheral neuropathic hyperalgesia. (6/2095)

We investigated the effects of OT-7100, a novel analgesic compound (5-n-butyl-7-(3,4,5-trimethoxybenzoylamino)pyrazolo[1,5-a]pyrimidi ne), on prostaglandin E2 biosynthesis in vitro, acute hyperalgesia induced by yeast and substance P in rats and hyperalgesia in rats with a chronic constriction injury to the sciatic nerve (Bennett model), which is a model for peripheral neuropathic pain. OT-7100 did not inhibit prostaglandin E2 biosynthesis at 10(-8)-10(-4) M. Single oral doses of 3 and 10 mg/kg OT-7100 were effective on the hyperalgesia induced by yeast. Single oral doses of 0.1, 0.3, 1 and 3 mg/kg OT-7100 were effective on the hyperalgesia induced by substance P in which indomethacin had no effect. Repeated oral administration of OT-7100 (10 and 30 mg/kg) was effective in normalizing the mechanical nociceptive threshold in the injured paw without affecting the nociceptive threshold in the uninjured paw in the Bennett model. Indomethacin had no effect in this model. While amitriptyline (10 and 30 mg/kg) and clonazepam (3 and 10 mg/kg) significantly normalized the nociceptive threshold in the injured paw, they also increased the nociceptive threshold in the uninjured paw. These results suggest that OT-7100 is a new type of analgesic with the effect of normalizing the nociceptive threshold in peripheral neuropathic hyperalgesia. (+info)

Nitric oxide mediates the central sensitization of primate spinothalamic tract neurons. (7/2095)

Nitric oxide (NO) has been proposed to contribute to the development of hyperalgesia by activating the NO/guanosine 3',5'-cyclic monophosphate (cGMP) signal transduction pathway in the spinal cord. We have examined the effects of NO on the responses of primate spinothalamic tract (STT) neurons to peripheral cutaneous stimuli and on the sensitization of STT cells following intradermal injection of capsaicin. The NO level within the spinal dorsal horn was increased by microdialysis of a NO donor, 3-morpholinosydnonimine (SIN-1). SIN-1 enhanced the responses of STT cells to both weak and strong mechanical stimulation of the skin. This effect was preferentially on deep wide dynamic range STT neurons. The responses of none of the neurons tested to noxious heat stimuli were significantly changed when SIN-1 was administered. Intradermal injection of capsaicin increased dramatically the content of NO metabolites, NO-2/NO-3, within the dorsal horn. This effect was attenuated by pretreatment of the spinal cord with a nitric oxide synthase (NOS) inhibitor, NG-nitro-L-arginine methyl ester (L-NAME). Sensitization of STT cells induced by intradermal injection of capsaicin was also prevented by pretreatment of the dorsal horn with the NOS inhibitors, L-NAME or 7-nitroindazole. Blockade of NOS did not significantly affect the responses of STT cells to peripheral stimulation in the absence of capsaicin injection. The data suggest that NO contributes to the development and maintenance of central sensitization of STT cells and the resultant mechanical hyperalgesia and allodynia after peripheral tissue damage or inflammation. NO seems to play little role in signaling peripheral stimuli under physiological conditions. (+info)

Epinephrine produces a beta-adrenergic receptor-mediated mechanical hyperalgesia and in vitro sensitization of rat nociceptors. (8/2095)

Hyperalgesic and nociceptor sensitizing effects mediated by the beta-adrenergic receptor were evaluated in the rat. Intradermal injection of epinephrine, the major endogenous ligand for the beta-adrenergic receptor, into the dorsum of the hindpaw of the rat produced a dose-dependent mechanical hyperalgesia, quantified by the Randall-Selitto paw-withdrawal test. Epinephrine-induced hyperalgesia was attenuated significantly by intradermal pretreatment with propranolol, a beta-adrenergic receptor antagonist, but not by phentolamine, an alpha-adrenergic receptor antagonist. Epinephrine-induced hyperalgesia developed rapidly; it was statistically significant by 2 min after injection, reached a maximum effect within 5 min, and lasted 2 h. Injection of a more beta-adrenergic receptor-selective agonist, isoproterenol, also produced dose-dependent hyperalgesia, which was attenuated by propranolol but not phentolamine. Epinephrine-induced hyperalgesia was not affected by indomethacin, an inhibitor of cyclo-oxygenase, or by surgical sympathectomy. It was attenuated significantly by inhibitors of the adenosine 3',5'-cyclic monophosphate signaling pathway (the adenylyl cyclase inhibitor, SQ 22536, and the protein kinase A inhibitors, Rp-adenosine 3',5'-cyclic monophosphate and WIPTIDE), inhibitors of the protein kinase C signaling pathway (chelerythrine and bisindolylmaleimide) and a mu-opioid receptor agonist DAMGO ([D-Ala2,N-Me-Phe4,Gly5-ol]-enkephalin). Consistent with the hypothesis that epinephrine produces hyperalgesia by a direct action on primary afferent nociceptors, it was found to sensitize small-diameter dorsal root ganglion neurons in culture, i. e., to produce an increase in number of spikes and a decrease in latency to firing during a ramped depolarizing stimulus. These effects were blocked by propranolol. Furthermore epinephrine, like several other direct-acting hyperalgesic agents, caused a potentiation of tetrodotoxin-resistant sodium current, an effect that was abolished by Rp-adenosine 3',5'-cyclic monophosphate and significantly attenuated by bisindolylmaleimide. Isoproterenol also potentiated tetrodotoxin-resistant sodium current. In conclusion, epinephrine produces cutaneous mechanical hyperalgesia and sensitizes cultured dorsal root ganglion neurons in the absence of nerve injury via an action at a beta-adrenergic receptor. These effects of epinephrine are mediated by both the protein kinase A and protein kinase C second-messenger pathways. (+info)

Shu XQ, Mendell LM (July 1999). "Neurotrophins and hyperalgesia". Proceedings of the National Academy of Sciences of the United ...

https://en.wikipedia.org/wiki/Brain-derived_neurotrophic_factor

Pretreatment with MK-801 significantly reduced SP induced hyperalgesia. Intrathecal MK-801 also blocked hyperalgesia resulting ... Allodynia and hyperalgesia were experimentally induced by administration of CCK into the RVM. Spinal administration of SB- ... Behavioral hyperalgesia in inflammatory pain states is closely correlated with phosphorylation of spinal NMDA receptors. To ... Injection of the CCK-saporin conjugate also reversed allodynia and hyperalgesia in a nerve injury model, producing the same ...

https://en.wikipedia.org/wiki/Rostral_ventromedial_medulla

Increased AT2R activity causes hyperalgesia. AT2R antagonist EMA401 inhibits the downstream effects of AT2R activation, ... both reversing and/or preventing potentiation that causes hyperalgesia. AngII increases neuronal excitability to TRPV1 channel ...

https://en.wikipedia.org/wiki/EMA401

Coutaux A, Adam F, Willer JC, Le Bars D (2005). "Hyperalgesia and allodynia: peripheral mechanisms". Joint Bone Spine. 72 (5): ... Allodynia is different from hyperalgesia, an extreme, exaggerated reaction to a stimulus which is normally painful. There are ...

https://en.wikipedia.org/wiki/Allodynia

... and inflammation-based pain and hyperalgesia. Lipoxins have protective effects in animal models of infection-based inflammation ...

https://en.wikipedia.org/wiki/Lipoxin

Normally hyperalgesia ceases when inflammation goes down, however, sometimes genetic defects and/or repeated injury can result ... This is commonly known as hyperalgesia. Inflammation is one common cause that results in the sensitization of nociceptors. ...

https://en.wikipedia.org/wiki/Nociceptor

Opioid-induced hyperalgesia Kraychete, Durval Campos; Sakata, Rioko Kimiko. "Use and Rotation of Opioids in Chronic Non- ...

https://en.wikipedia.org/wiki/Opioid_rotation

Evidence for a link between PGE2 and hyperalgesia comes from an antisense deoxynucleotide knockdown of Nav1.8 in the DRG of ... Lai J, Porreca F, Hunter JC, Gold MS (2004). "Voltage-gated sodium channels and hyperalgesia". Annual Review of Pharmacology ... Therefore, Nav1.8 contributes to hyperalgesia (increased sensitivity to pain) and allodynia (pain from stimuli that do not ... hyperalgesia). The increased levels of nerve growth factor and tumour necrosis factor-α (TNF-α) causes the upregulation of ...

https://en.wikipedia.org/wiki/Nav1.8

It has anti-hyperalgesia effects in animals. SIB-1757 along with other mGluR5 antagonists has been shown to have ...

https://en.wikipedia.org/wiki/SIB-1757

His studies on the basic mechanisms involved in the development of inflammatory hyperalgesia led to the discovery that a select ... II-Prostaglandins hyperalgesia: the peripheral analgesic activity of morphine, enkephalins and opioid antagonists. ... Bradykinin initiates cytokine mediated inflammatory hyperalgesia. Brazilian Journal of Pharmacological Sciences. vol. 110, p. ... group made a relevant contribution to the role of bradykinin and of cytokines in the development of inflammatory hyperalgesia. ...

https://en.wikipedia.org/wiki/Sérgio_Henrique_Ferreira

Sommer C, Schäfers M, Marziniak M, Toyka KV (June 2001). "Etanercept reduces hyperalgesia in experimental painful neuropathy". ...

https://en.wikipedia.org/wiki/Failed_back_syndrome

People suffering from this probably have hyperalgesia. The Fear of Pain Questionnaire (currently the FPQ-III) has been used to ...

https://en.wikipedia.org/wiki/Algophobia

The original Hp peptide reduces sensitivity to painful stimuli in an experimental model of hyperalgesia. Hp also reduces food ... March 2005). "Antinociceptive action of hemopressin in experimental hyperalgesia". Peptides. 26 (3): 431-6. doi:10.1016/j. ...

https://en.wikipedia.org/wiki/Hemopressin

"CXCR4 Signaling Mediates Morphine-induced Tactile Hyperalgesia". Brain, Behavior, and Immunity. 25 (3): 565-73. doi:10.1016/j. ... of CXCR4 signalling by plerixafor has also unexpectedly been found to be effective at counteracting opioid-induced hyperalgesia ...

https://en.wikipedia.org/wiki/Plerixafor

DuPen A, Shen D, Ersek M (September 2007). "Mechanisms of opioid-induced tolerance and hyperalgesia". Pain Management Nursing. ...

https://en.wikipedia.org/wiki/Μ-opioid_receptor

Syriatowicz, J. P.; Hu, D.; Walker, J. S.; Tracey, D. J. (1999). "Hyperalgesia due to nerve injury: Role of prostaglandins". ... a compound that sensitizes neurons to mechanical stimuli and mechanical hyperalgesia) which further supports a role for HT ...

https://en.wikipedia.org/wiki/Dorsal_root_ganglion

Hyperalgesia which remains in the initial area is known as primary hyperalgesia, and hyperalgesia which extends to a large area ... Hyperalgesia to mechanical stimuli extends to a large area around the initial location of the stimulus, while hyperalgesia to ... which is a chemical commonly used to induce hyperalgesia. Secondary hyperalgesia is believed to be caused by a magnified spinal ... Primary hyperalgesia probably relies on a central mechanism. It is argued that MIAs, or C-MiHi primary afferents, are crucial ...

https://en.wikipedia.org/wiki/Mechanosensation

... hyperalgesia is believed to involve the activation of cholecystokinin receptors. In a paper, Stewart-Williams and Podd ... For example, precisely the same inert agents can produce analgesia and hyperalgesia, the first of which, from this definition, ... Stewart-Williams & Podd (2004), p.326 Colloca, L; Benedetti, F (Oct 2007). "Nocebo hyperalgesia: how anxiety is turned into ... Verbal suggestion can cause hyperalgesia (increased sensitivity to pain) and allodynia (perception of a tactile stimulus as ...

https://en.wikipedia.org/wiki/Nocebo

Pöyhiä R, Vainio A (January 2006). "Topically administered ketamine reduces capsaicin-evoked mechanical hyperalgesia". The ... or hyperalgesia after a nerve injury, not necessarily limited to the distribution of the injured nerve Evidence at some time of ... or hyperalgesia (an exaggerated sense of pain) disproportionate to the inciting event Evidence at some time of edema, changes ... mechanical hyperalgesia) and showed a "significantly increased activation" of not just the S1 cortex (contralateral), S2 ( ...

https://en.wikipedia.org/wiki/Complex_regional_pain_syndrome

Hyperalgesia is directly involved with spinal NMDA receptors. Administered NMDA antagonists in a clinical setting produce ...

https://en.wikipedia.org/wiki/Glutamate_receptor

Hyperalgesia Hypoalgesic effect of swearing Vane, J. (2003). "The mechanism of action of anti-inflammatory drugs." Int J Clin ...

https://en.wikipedia.org/wiki/Hypoalgesia

Nature (2008) 2002 : Shin J et al., Bradykinin-12-lipoxygenase-VR1 signaling pathway for inflammatory hyperalgesia. Proc Natl ... 2002). "Bradykinin-12-lipoxygenase-VR1 signaling pathway for inflammatory hyperalgesia". Proc. Natl. Acad. Sci. USA. 99 (15): ...

https://en.wikipedia.org/wiki/Oh_Uhtaek

"Adenosine receptor subtype-selective antagonists in inflammation and hyperalgesia". Naunyn-Schmiedeberg's Archives of ...

https://en.wikipedia.org/wiki/PSB-10

This hyper-excitability can be caused by an increased neuronal response to a noxious stimulus (hyperalgesia), a larger neuronal ... This abnormal central sensitization cycle results in increased pain (hyperalgesia) and pain responses from previously non- ... al (2000). "Vanilloid receptor-1 is essential for inflammatory thermal hyperalgesia". Nature. 405 (6783): 183-7. doi:10.1038/ ...

https://en.wikipedia.org/wiki/Group_C_nerve_fiber

Studies have shown dysregulation of NGF causes hyperalgesia and pain. NGF production is highly correlated to the extent of ...

https://en.wikipedia.org/wiki/Neurotrophic_factors

Interleukin-1 and tumour necrosis factor are involved in cutaneous hyperalgesia. Corticosteroids A few patients noted some ...

https://en.wikipedia.org/wiki/Adiposis_dolorosa

Bonin R. P. & De Koninck Y. (2014). "A spinal analogue of memory reconsolidation enables the erasure of hyperalgesia". Nat ...

https://en.wikipedia.org/wiki/Memory_consolidation

This maladaptive change results in the experience of allodynia or hyperalgesia. Brain activity in individuals with chronic pain ... opioid-induced hyperalgesia, physical dependence, addiction, and overdose. Hypnosis, including self-hypnosis, has tentative ...

https://en.wikipedia.org/wiki/Chronic_pain

... a novel endogenous capsaicin-like lipid that produces hyperalgesia. Journal of Biological Chemistry, 278(16), 13633-13639. ...

https://en.wikipedia.org/wiki/N-Acylamides

These results indicate that the rats exhibited hyperalgesia, allodynia, and dysesthesia. In a study in which researchers cut ... and hyperalgesia. Additionally, the receptive field neurons in this nerve pathway showed spontaneous firing in low-threshold ...

https://en.wikipedia.org/wiki/Dysesthesia

Secondary hyperalgesia describes pain sensitivity that occurs in surrounding undamaged tissues. Opioid-induced hyperalgesia may ... Where hyperalgesia has been produced by chronic high doses of opioids, reducing the dose may result in improved pain management ... Hyperalgesia can be experienced in focal, discrete areas, or as a more diffuse, body-wide form. Conditioning studies have ... Hyperalgesia is induced by platelet-activating factor (PAF) which comes about in an inflammatory or an allergic response. This ...

https://en.wikipedia.org/wiki/Hyperalgesia

Opioid Induced Hyperalgesia (OIH) Modulation With Propranolol. The safety and scientific validity of this study is the ... Opioid Induced Hyperalgesia (OIH) Modulation With Propranolol, in Laparoscopic Abdominal Surgery. Study Start Date :. October ... Opioid Induced Hyperalgesia (OIH) is an entity than has been demonstrated in healthy volunteers and in animal models. Is ... The objective of this work is to evaluate the efficacy of propranolol in the modulation of opioid induced hyperalgesia, with ...

https://www.clinicaltrials.gov/ct2/show/NCT02934763?term=PROPRANOLOL&

Inflammatory hyperalgesia. A, Time course of mechanical hyperalgesia in WT and IKKε−/− mice after injection of 10 mg/ml (20 μl ... Intraplantar zymosan as a reliable, quantifiable model of thermal and mechanical hyperalgesia in the rat. Eur. J. Pain 1: 43-52 ... The Protein Kinase IKKε Is a Potential Target for the Treatment of Inflammatory Hyperalgesia. Christine V. Möser, Katharina ... 3, 28). On the one hand, our data indicated that IRF-3 is not activated during inflammatory hyperalgesia and, therefore, is ...

http://www.jimmunol.org/content/187/5/2617

This page contains the abstract Joint Manipulation Reduces Hyperalgesia By Activation of Monoamine Receptors But Not Opioid or ... GABA Receptors in the Spinal Cord http://www.chiro.org/LINKS/ABSTRACTS/Joint_Manipulation_Reduces_Hyperalgesia.shtml ... Joint Manipulation Reduces Hyperalgesia By Activation of Monoamine Receptors But Not Opioid or GABA Receptors in the Spinal ... Joint manipulation reverses mechanical hyperalgesia Two hours after injection of capsaicin into the ankle joint, there was a ...

http://www.chiro.org/LINKS/ABSTRACTS/Joint_Manipulation_Reduces_Hyperalgesia.shtml

Hyperalgesia and opioid consumption. Secondary outcome measures. Assess age differences in the intensity and course of ... Effects of NMDA-receptor antagonism on hyperalgesia, opioid use, and pain after major surgery in young and elderly patients. ... hyperalgesia and morbidity in younger and older patients. In order to achieve this aim, we propose to conduct the first ...

http://www.isrctn.com/ISRCTN64506738

Experimentally induced secondary hyperalgesia has been manipulated with pharmacological and non-pharmacological methods to ... Mechanistic research on neuropathic pain frequently uses human surrogate models of the secondary hyperalgesia that is a common ... hyperalgesia in humans and will help to clarify the relative contributions of different mechanisms to secondary hyperalgesia. ... and compare methods that have been used to manipulate experimentally induced secondary hyperalgesia in healthy humans. A ...

https://systematicreviewsjournal.biomedcentral.com/articles/10.1186/s13643-019-1120-7/metrics

Next, we found that CCK(2) (-/-) mice did not develop mechanical hyperalgesia in the Bennetts neuropathic pain model. ... 2004) Deletion of the CCK2 receptor gene reduces mechanical sensitivity and abolishes the development of hyperalgesia in ... Deletion of the CCK2 receptor gene reduces mechanical sensitivity and abolishes the development of hyperalgesia in ... as well as the development and time course of mechanical hyperalgesia in a model of neuropathic pain. We found that CCK(2 ...

https://researchrepository.murdoch.edu.au/id/eprint/52909/

Hyperalgesias, Primary , Hyperalgesias, Secondary , Hyperalgesias, Tactile , Hyperalgesias, Thermal , Hyperalgesia, Tactile , ... Hyperalgesia, Mechanical , Hyperalgesia, Primary , Hyperalgesias , Hyperalgesia, Secondary , Hyperalgesias, Mechanical , ... Hyperalgesia 2.. Diseases ← Pathological Conditions, Signs and Symptoms ← Signs and Symptoms ← Neurologic Manifestations ← ... Hyperalgesia, Thermal , Hyperalgesic Sensations , Mechanical Allodynia , Mechanical Hyperalgesia , Tactile Allodynia , Thermal ...

http://ctdbase.org/detail.go?type=disease&acc=MESH%3AD006930

... 16 May Inﬂammation causes an increased synthesis of COX-2-dependent prostaglan- dins, which ... tiﬁed PGE2 receptors of the EP2 receptor subtype as key signaling elements in spinal inﬂammatory hyperalgesia (Reinold et al. ... Experimental data suggest that both acidic and nonacidic COX inhibitors antagonize central hy- peralgesia in the dorsal horn of ... 3a, b Molecular mechanisms underlying peripheral and central hyperalgesia elicited by prostaglandin E2 (adapted from Brune and ...

http://fx.damasgate.com/mechanisms-of-hyperalgesia/

Hyperalgesia was elicited in C57BL/6 mice by injection of recombinant IL-17, TNF or vehicle into the plantar tissue. Elevated ... Cellular infiltration during hyperalgesia was determined by histological analysis and myeloperoxidase assay. IL-17 was found to ... We aimed to establish whether IL-17 can induce hyperalgesia in acute conditions, and investigated the role of TNF in mediating ... These findings suggest that IL-17 causes acute hyperalgesia indirectly by inducing TNF from resident cells. The subsequent ...

https://www.ndorms.ox.ac.uk/publications/224041

"Victorian Halls released Hyperalgesia @ Bottom Lounge". The Deli Magazine. 19 May 2015. Retrieved 30 June 2017. "Hyperalgesia ... Hyperalgesia is the second full-length studio album by American alternative rock band Victorian Halls from Chicago, Illinois, ...

https://en.wikipedia.org/wiki/Hyperalgesia_(album)

Information about visceral hyperalgesia causes, symptoms, diagnosis and treatment from the experts at Cincinnati Childrens ... Visceral Hyperalgesia What Is Visceral Hyperalgesia? Visceral hyperalgesia is an increased sensitivity to pain in the internal ... How Is Visceral Hyperalgesia Diagnosed?Show There is no specific test to diagnose visceral hyperalgesia. It is generally ... What Causes Visceral Hyperalgesia? Show Increased sensitivity usually starts when something causes irritation to a particular ...

https://www.cincinnatichildrens.org/health/v/visceral-hyperalgesia

We explore the cause of hyperalgesia. We also examine the various types of the condition and the most effective treatments. ... Other types of hyperalgesia. Another kind of hyperalgesia is opioid-induced hyperalgesia (OIH). OIH occurs when a person ... Primary hyperalgesia. This type of hyperalgesia is when the increased pain occurs in the tissue where the injury took place. An ... Diagnosing hyperalgesia may be difficult for a doctor.. Hyperalgesia can present difficulties for a doctor to treat because a ...

https://www.medicalnewstoday.com/articles/318791

Secondary hyperalgesia describes pain sensitivity that occurs in surrounding undamaged tissues.. Opioid-induced hyperalgesia ... Hyperalgesia (/ˌhaɪpərælˈdʒiːziə/ or /-siə/; hyper from Greek ὑπέρ (huper, "over"), -algesia from Greek algos, ἄλγος (pain ... Hyperalgesia is induced by platelet-activating factor (PAF) which comes about in an inflammatory or an allergic response. This ... One unusual cause of focal hyperalgesia is platypus venom.[5]. Long-term opioid (e.g. heroin, morphine) users and those on high ...

https://en.m.wikipedia.org/wiki/Hyperalgesia

Attenuation of thermal nociception and hyperalgesia by VR1 blockers. Carolina García-Martínez, Marc Humet, Rosa Planells-Cases ... Attenuation of thermal nociception and hyperalgesia by VR1 blockers. Carolina García-Martínez, Marc Humet, Rosa Planells-Cases ... Mustard Oil Thermal Hyperalgesia.. Thermal sensitivity of mice was assayed in the hot plate at 52°C. Thereafter, mustard oil ( ... 6 A and B). As expected, mice sensitized with capsaicin showed intense mechanical hyperalgesia in the treated paw (Fig. 6C). ...

https://www.pnas.org/content/99/4/2374?ijkey=c62abba5ae5ce4c6b2f06124bc9bf98667a6e607&keytype2=tf_ipsecsha

Activation of non-neuronal microglia is thought to play a causal role in spinal processing of neuropathic pain. To specifically investigate microglia-mediated effects in a model of neuropathic pain and overcome the methodological limitations of previous approaches exploring microglia function upon nerve injury, we selectively ablated resident microglia by intracerebroventricular ganciclovir infusion into male CD11b-HSVTK-transgenic mice, which was followed by a rapid, complete, and persistent (23 weeks) repopulation of the CNS by peripheral myeloid cells. In repopulated mice that underwent sciatic nerve injury, we observed a normal response to mechanical stimuli, but an absence of thermal hypersensitivity ipsilateral to the injured nerve. Furthermore, we found that neuronal expression of calcitonin gene-related peptide (CGRP), which is a ...

https://www.jci.org/articles/view/95305/figure/4

Erythromelalgia(heat hyperalgesia) is in part due to mutations in TTX sensitivity of channel Na 1.7 (Sodium 1.7). Trigeminal ... Knockout IL-1 receptor and reduce hyperalgesia Sodium Channel Dysfunction can contribute to pain. Channel Na 1.3 (Sodium 1.3) ...

https://www.dailystrength.org/group/neuropathy/discussion/neuropathic-pain-hyperalgesia-amp-trigeminal-neu_1

Diseases : Hyperalgesia, Hyperglycemia, Neuropathic Pain. Pharmacological Actions : Analgesics, Antioxidants, Bax/Bcl2 Ratio: ... Diseases : Hyperalgesia, Inflammation, Neuropathic Pain. Pharmacological Actions : NF-kappaB Inhibitor, Nitric Oxide Inhibitor ... Diseases : Hyperalgesia, Neuropathic Pain, Rheumatoid Arthritis. Pharmacological Actions : Analgesics, Wnt/β-catenin signaling ... Diseases : Hyperalgesia, Oxidative Stress. Pharmacological Actions : Interleukin-1 beta downregulation, NF-kappaB Inhibitor, ...

https://www.greenmedinfo.com/disease/hyperalgesia

... Leonardo Yung dos Santos Maciel,1 Kamilla ... C. Huang, Z.-P. Hu, H. Long, Y.-S. Shi, J.-S. Han, and Y. Wan, "Attenuation of mechanical but not thermal hyperalgesia by ... T. Yokoyama, Y. Maeda, K. M. Audette, and K. A. Sluka, "Pregabalin reduces muscle and cutaneous hyperalgesia in two models of ... Y. Zhang, A. Li, J. Xin et al., "Involvement of spinal serotonin receptors in electroacupuncture anti-hyperalgesia in an ...

https://www.hindawi.com/journals/ecam/2014/485043/ref/

... was conducted to evaluate the efficacy of oral cryotherapy during oxaliplatin infusions to prevent oral thermal hyperalgesia ( ...

https://uspharmacist.com/article/ice-chips-prevent-hyperalgesia-with-oxaliplatin

... Anne-Kathrin Bräscher,1 Michael ... K. Świder and P. Bąbel, "The effect of the sex of a model on nocebo hyperalgesia induced by social observational learning," ... B. Colagiuri, V. F. Quinn, and L. Colloca, "Nocebo hyperalgesia, partial reinforcement, and extinction," Journal of Pain, vol. ... E. Vögtle, A. Barke, and B. Kröner-Herwig, "Nocebo hyperalgesia induced by social observational learning," Pain, vol. 154, no. ...

https://www.hindawi.com/journals/prm/2018/6841985/

We assessed postoperative pain at rest and with movement along with wound hyperalgesia in a patient ... Wound hyperalgesia was also determined on each side of the horizontal incision with an algometer (8,9). These data are shown in ... Pain and wound hyperalgesia were consistently greater on the "unblocked" side for the 3-wk period of observation. Thus, even ... Prolonged Differential Wound Hyperalgesia After an Interval of Unilateral Epidural Blockade During Lower Abdominal Surgery. ...

http://journals.lww.com/anesthesia-analgesia/Fulltext/2005/05000/Prolonged_Differential_Wound_Hyperalgesia_After_an.39.aspx

... and possibly opioid-induced hyperalgesia (OIH). The purpose of this review is to evaluate the occurrence and significance of ... opioid-induced hyperalgesia (OIH) after acute fentanyl exposure. A … ... Keywords: drug-related side effect; fentanyl; hyperalgesia; opioid; opioid-induced hyperalgesia; pain; tolerance. ... Fentanyl-induced hyperalgesia in acute pain management J Pain Palliat Care Pharmacother. 2015 Jun;29(2):153-60. doi: 10.3109/ ...

https://pubmed.ncbi.nlm.nih.gov/26095487/

Chemical compound and disease context of Hyperalgesia. *Here we present a new model for noradrenaline-sensitive hyperalgesia ... Psychiatry related information on Hyperalgesia. *Both the visceral hyperalgesia and the decrease in somatic pain thresholds ... Hyperalgesia mediated by spinal glutamate or substance P receptor blocked by spinal cyclooxygenase inhibition. Malmberg, A.B., ... Spinal inflammatory hyperalgesia is mediated by prostaglandin E receptors of the EP2 subtype. Reinold, H., Ahmadi, S., Depner, ...

https://www.wikigenes.org/e/mesh/e/10156.html

... this neurotransmitter being associated with hyperalgesia and central sensitization. One of the mechanisms underlying these ... Chronic Monosodium Glutamate Administration Induced Hyperalgesia in Mice by Anca Zanfirescu, Aurelia Nicoleta Cristea, George ... Keywords: monosodium glutamate; hyperalgesia; hot-plate test; formalin test; nitric oxide synthase monosodium glutamate; ... "Chronic Monosodium Glutamate Administration Induced Hyperalgesia in Mice." Nutrients 10, no. 1: 1. ...

https://www.mdpi.com/2072-6643/10/1/1

H2 2018Global Markets Directs latest Pharmaceutical and Healthcare disease pipeline guide Hyperalgesia - Pipeline Review, H2 ... 2018, provides an overview of the Hyperalgesia (Central Nervous System). ... Hyperalgesia - Pipeline by Charleston Laboratories Inc, H2 2018. Hyperalgesia - Pipeline by Novartis AG, H2 2018. Hyperalgesia ... Hyperalgesia - Pipeline by Abide Therapeutics Inc, H2 2018. Hyperalgesia - Pipeline by Boehringer Ingelheim GmbH, H2 2018. ...

https://www.aarkstore.com/pharmaceuticals-healthcare/967571/hyperalgesia-pipeline-review-h2-2018

Pericicatricial hyperalgesia area [ Time Frame: 72 hours after surgery ]. Secondary Outcome Measures: *Pain intensity (rest/ ... Hyperalgesia, postoperative. Local anesthetic, ropivacaine, lidocaine. Colorectal laparoscopic surgery. Pain management after ... Besides hyperalgesia assessment, immediate postoperative and long-term pain, morphine consumption, and endocrin-metabolic ... Hyperalgesia. Pain. Neurologic Manifestations. Nervous System Diseases. Postoperative Complications. Pathologic Processes. ...

https://clinicaltrials.gov/ct2/show/NCT01077752

Hyperalgesia Opioid-Related Disorders Drug: Acetazolamide Drug: Placebo Oral Tablet Phase 4 ... Administration of Acetazolamide to Prevent Remifentanil Induced Hyperalgesia. The safety and scientific validity of this study ... There is a lot of evidence that suggest that the used of remifentanil is associated with the development of hyperalgesia (a ... Hyperalgesia. Opioid-Related Disorders. Somatosensory Disorders. Sensation Disorders. Neurologic Manifestations. Nervous System ...

https://www.clinicaltrials.gov/ct2/show/NCT02992938?term=region&cntry=CL&rank=20

... showed a robust response during the perception of secondary hyperalgesia but not primary hyperalgesia (i.e., no mPFC responses ... Secondary hyperalgesia is generally defined as the development of a heightened sensitivity to normal mechanical stimulation in ... Because secondary hyperalgesia pain thresholds were not matched across participants, the pin-prick stimulation used to evoke ... Medial Prefrontal Cortex, Secondary Hyperalgesia, and the Default Mode Network Message Subject (Your Name) has forwarded a page ...

http://www.jneurosci.org/content/29/37/11424

Involvement of vasopressin 3 receptors in chronic psychological stress-induced visceral hyperalgesia in rats.. Bradesi S1, ... These data support a major role for V(3) receptors in repeated psychological stress-induced visceral hyperalgesia and suggest ... Repeated administration of SSR149415 at 1 or 3 mg/kg completely prevented stress-induced visceral hyperalgesia. Similarly, a ... signaling system in the development of stress-induced visceral hyperalgesia in rats. Rats were exposed to a daily 1-h session ...

https://www.ncbi.nlm.nih.gov/pubmed/19033533

... indicative of hyperalgesia. The higher the fentanyl dose used, the more pronounced was the fentanyl-induced hyperalgesia. ... Long-lasting hyperalgesia induced by fentanyl in rats: preventive effect of ketamine.. Célèrier E1, Rivat C, Jun Y, Laulin JP, ... and prevented the development of long-lasting hyperalgesia. ...

https://www.ncbi.nlm.nih.gov/pubmed/10691234?dopt=Abstract

Fenobam on Heat/Capsaicin Induced Hyperalgesia in Healthy Volunteers. The safety and scientific validity of this study is the ... Hyperalgesia. Somatosensory Disorders. Sensation Disorders. Neurologic Manifestations. Nervous System Diseases. Signs and ... size of the area of hyperalgesia and allodynia around the area sensitized by heat/capsaicin as quantified by cutaneous ... Suppression of the development of cutaneous hyperalgesia and allodynia around the area treated with heat/capsaicin. [ Time ...

https://clinicaltrials.gov/ct2/show/NCT01981395

... and hyperalgesia (increased pain sensitivity). Clinical and preclinical studies have reported development of hyperalgesia after ... attenuated morphine-induced hyperalgesia. Real-time polymerase chain reaction (RT-PCR) analysis showed that CREB downstream ... attenuated morphine-induced hyperalgesia. Real-time polymerase chain reaction (RT-PCR) analysis showed that CREB downstream ... without interfering with the morphine-induced hyperalgesia. However, i.t. injection of SB20358, a p38 inhibitor and SP660125, a ...

https://www.frontiersin.org/articles/10.3389/fnins.2019.01018/full

Opioid-induced hyperalgesia (OIH) is most broadly defined as a state of nociceptive sensitization caused by exposure to opioids ... Opioid-induced Hyperalgesia in Humans: Molecular Mechanisms and Clinical Considerations Clin J Pain. Jul-Aug 2008;24(6):479-96. ... Opioid-induced hyperalgesia (OIH) is most broadly defined as a state of nociceptive sensitization caused by exposure to opioids ...

https://pubmed.ncbi.nlm.nih.gov/18574358/?dopt=Abstract

Efficacy of a Polyamine-free Diet Associated or Not With Ketamine on Early and Late Hyperalgesia After Breast Cancer Surgery. ... Efficacy of a Polyamine-free Diet Associated or Not With Ketamine on Early and Late Hyperalgesia After Breast Cancer Surgery ... group as well as pain score, allodynia (Von Frey filaments) and hyperalgesia (algometer).. Chronic pain occurrence (post- ...

http://www.knowcancer.com/cancer-trials/NCT00304850/

Redox modulation of peripheral T-type Ca2+ channels in vivo: alteration of nerve injury-induced thermal hyperalgesia Pain 2004 ... To begin to understand the cellular and molecular mechanisms of hyperalgesia associated with PDN in ob/ob mice, we examined the ... Diabetic α1H−/− mice do not develop early hyperalgesia and are resistant to the effects of ECN in tests of mechanical and ... 5α-reduced neuroactive steroids alleviate thermal and mechanical hyperalgesia in rats with neuropathic pain Pain 2005; 117: 326 ...

http://diabetes.diabetesjournals.org/content/58/11/2656.full

Blockage of P2X7R at the DRG reduced the mechanical hyperalgesia induced by CFA, and prevented the mechanical hyperalgesia ... Blockage of P2X7R at the DRG reduced the mechanical hyperalgesia induced by CFA, and prevented the mechanical hyperalgesia ... This evidence places the SGC as an active player in the establishment of peripheral inflammatory hyperalgesia and highlights ... activation of P2X7R by ATP and the subsequent release of IL-1β in DRG participate in peripheral inflammatory hyperalgesia. ...

https://www.frontiersin.org/articles/10.3389/fphys.2020.00473/full

Hyperalgesia and Allodynia: A Closer Look. Symptoms, Mechanisms and Treatment. Merab G. Tsagareli (Editor). Ivane Beritashvili ... Home / Shop / Upcoming Publications / Hyperalgesia and Allodynia: A Closer Look. Symptoms, Mechanisms and Treatment. ... Chapter 7. Agonist-Evoked Hyperalgesia and Allodynia: The Role of Transient Receptor Potential Channels in Pain and Itch. ( ... Chapter 1. Allodynia and Hyperalgesia in Pain Sensation: Prefatory Chapter. (Merab G. Tsagareli, Beritashvili Center for ...

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Secondary hyperalgesia describes pain sensitivity that occurs in surrounding undamaged tissues. (wikipedia.org)
Various studies of humans and animals have demonstrated that primary or secondary hyperalgesia can develop in response to both chronic and acute exposure to opioids. (wikipedia.org)

Hyperalgesia is similar to other sorts of pain associated with nerve irritation or damage such as allodynia and neuropathic pain, and consequently may respond to standard treatment for these conditions, using various drugs such as SSRI or tricyclic antidepressants, Nonsteroidal anti-inflammatory drugs (NSAIDs), glucocorticoids, gabapentin or pregabalin, NMDA antagonists, or atypical opioids such as tramadol. (wikipedia.org)

Elevated pain was measured by the Hargreaves test for thermal hyperalgesia and Linton incapacitance tester for weight-bearing change. (ox.ac.uk)
For that reason, reside S. aureus infection induces instant, dose-dependent spontaneous pain, followed by robust mechanical and thermal hyperalgesia that lasts for days post infection. (amparinhibitor.com)

We used CCK(2) receptor deficient (CCK(2) (-/-)) mice and assessed their mechanical sensitivity using Von Frey filaments, as well as the development and time course of mechanical hyperalgesia in a model of neuropathic pain. (edu.au)
Next, we found that CCK(2) (-/-) mice did not develop mechanical hyperalgesia in the Bennett's neuropathic pain model. (edu.au)

Opioid-induced hyperalgesia may develop as a result of long-term opioid use in the treatment of chronic pain. (wikipedia.org)
Long-term opioid (e.g. heroin, morphine) users and those on high-dose opioid medications for the treatment of chronic pain, may experience hyperalgesia and experience pain out of proportion to physical findings, which is a common cause for loss of efficacy of these medications over time. (wikipedia.org)
As it can be difficult to distinguish from tolerance, opioid-induced hyperalgesia is often compensated for by escalating the dose of opioid, potentially worsening the problem by further increasing sensitivity to pain. (wikipedia.org)
Opioid Induced Hyperalgesia (OIH) is an entity than has been demonstrated in healthy volunteers and in animal models. (clinicaltrials.gov)
The objective of this work is to evaluate the efficacy of propranolol in the modulation of opioid induced hyperalgesia, with lower postoperative requirements of analgesia rescue. (clinicaltrials.gov)
Also, as a secondary outcome, in a group than will not receive the study drug, we will evaluate the temporal changes in opioid induced hyperalgesia, by pain sensitivity measured in the postoperative hours 2, 4 and 24. (clinicaltrials.gov)

IL-17 induces hyperalgesia via TNF-dependent neutrophil infiltration. (ox.ac.uk)

The focal form is typically associated with injury, and is divided into two subtypes: Primary hyperalgesia describes pain sensitivity that occurs directly in the damaged tissues. (wikipedia.org)

Because TNF-induced hyperalgesia was also dependent on neutrophil migration, the relationship between the resident fibroblasts, the cytokines and the migrating neutrophils was further investigated. (ox.ac.uk)

Infection, we discovered infection with each mid-log and stationary phase S. aureus-induced comparable levels of both spontaneous pain and mechanical hyperalgesia (Supplementary Fig. 2). (amparinhibitor.com)

Amplification in the spinal cord may be another way of producing hyperalgesia. (wikipedia.org)

Hyperalgesia was elicited in C57BL/6 mice by injection of recombinant IL-17, TNF or vehicle into the plantar tissue. (ox.ac.uk)

These findings suggest that IL-17 causes acute hyperalgesia indirectly by inducing TNF from resident cells. (ox.ac.uk)

Cellular infiltration during hyperalgesia was determined by histological analysis and myeloperoxidase assay. (ox.ac.uk)

One major pathway being through stimulation of the nociceptin receptor, and blocking this receptor may therefore be a means of preventing the development of hyperalgesia. (wikipedia.org)
The use of a transcutaneous electrical nerve stimulation device has been shown to alleviate hyperalgesia. (wikipedia.org)

We aimed to establish whether IL-17 can induce hyperalgesia in acute conditions, and investigated the role of TNF in mediating the pain response. (ox.ac.uk)

However, as with other forms of nerve dysfunction associated pain, treatment of hyperalgesia can be clinically challenging, and finding a suitable drug or drug combination that is effective for a particular patient may require trial and error. (wikipedia.org)

IL-17 was found to induce hyperalgesia, but this was dependent on neutrophil migration and TNF binding to TNF receptor 1 (TNFR1). (ox.ac.uk)

Where hyperalgesia has been produced by chronic high doses of opioids, reducing the dose may result in improved pain management. (wikipedia.org)

Involvement of vasopressin 3 receptors in chronic psychological stress-induced visceral hyperalgesia in rats. (nih.gov)
We used a selective vasopressin 3 (V(3)) receptor antagonist SSR149415 to investigate the involvement of the vasopressin (AVP)/V(3) signaling system in the development of stress-induced visceral hyperalgesia in rats. (nih.gov)
Long-lasting hyperalgesia induced by fentanyl in rats: preventive effect of ketamine. (nih.gov)
Clinical and preclinical studies have reported development of hyperalgesia after prolonged opioid administration or after a single dose of intrathecal (i.t.) morphine in uninjured rats. (frontiersin.org)
Here, we showed that a single morphine subcutaneous injection induces analgesia followed by a long-lasting delayed hyperalgesia in uninjured and PGE2 sensitized rats. (frontiersin.org)
We have shown recently that opiates produce not only analgesia but also long-lasting hyperalgesia in rats. (jneurosci.org)
Our observation that a small dose of heroin which is ineffective for triggering a delayed hyperalgesia in non-heroin-treated rats induced an enhancement in pain sensitivity for several days after a series of heroin administrations is in agreement with the sensitization hypothesis. (jneurosci.org)
The effectiveness of the opioid receptor antagonist naloxone to precipitate hyperalgesia in rats that had recovered their pre-drug nociceptive value after single or repeated heroin administrations indicates that heroin-deprived rats were in a new biological state associated with a high level balance between opioid-dependent analgesic systems and pronociceptive systems. (jneurosci.org)
Nociceptive somatic stimulation in neonatal rats results in chronic visceral hyperalgesia. (lww.com)
The ability of repeated morphine administration to produce hyperalgesia was studied in rats. (aspetjournals.org)
Furthermore, when exposed to inflammatory insults or known mediators, naked mole-rats do not display thermal hyperalgesia.Nevertheless, the activation of capsaicin-sensitive sensory neurons in naked mole-rats does not produce pain-related behavior.The pain biology of the naked mole-rat is unique among mammals, thus the study of pain mechanisms in this unusual species can provide major insights into what constitutes 'normal' mammalian nociception. (nih.gov)
Furthermore, when exposed to inflammatory insults or known mediators, naked mole-rats do not display thermal hyperalgesia. (nih.gov)
In contrast, naked mole-rats do display nocifensive behaviors in the formalin test and show mechanical hyperalgesia after inflammation. (nih.gov)
Naked mole-rats also display hyperalgesia following intrathecal SP injection albeit only at higher doses (100 μM, n = 6 animals per dose). (nih.gov)
In rats injected with complete Freund's adjuvant (CFA), which induces inflammatory heat hyperalgesia, DRG neurons showed an increase in LIMK activity and in the phosphorylation and thus inhibition of the LIMK substrate cofilin, an actin-severing protein. (sciencemag.org)
This study investigated the role of SAP102 in the formation of hyperalgesia in rats with CIBP SAP102 is present in spinal dorsal horn neurons, but not in astrocytes or microglia. (medworm.com)
Extended access to nicotine leads to a CRF1 receptor dependent increase in anxiety-like behavior and hyperalgesia in rats. (sigmaaldrich.com)
Enhanced excitability of sensory neurons in rats with cutaneous hyperalgesia produced by chronic compression of the dorsal root ganglion. (biomedsearch.com)
Postoperatively, the threshold force applied by punctate stimulation of the plantar surface of the hind paw decreased significantly on the foot ipsilateral to the CCD (mechanical hyperalgesia) but changed little on the contralateral foot or on either foot for control rats. (biomedsearch.com)
Based on our studies using a model of intermittent sound stress in rats, we have suggested that sound stress-induced enhancement of immune mediator hyperalgesia requires activity in both neuroendocrine stress axes: the sympathoadrenal (via release of epinephrine) and hypothalamic pituitary adrenal (HPA) (via release of corticosterone) 12 . (pubmedcentralcanada.ca)
We found that two structurally dissimilar but equally potent sEH inhibitors can be delivered through the transdermal route and that sEH inhibitors effectively attenuate thermal hyperalgesia and mechanical allodynia in rats treated with LPS. (eurekamag.com)
In carrageenan-induced paw inflammation, pretreatment of rats with 2B5 substantially prevented the development of tissue edema and hyperalgesia in affected paws. (rupress.org)
Hyperalgesia during ethanol withdrawal is a robust phenomenon that has been observed in various strains of mice and rats, with different methods of exposure to ethanol, and with a variety of nociceptive assays. (unthsc.edu)
Upregulations of P2X3 and ASIC3 involve in hyperalgesia induced by cisplatin administration in rats. (blogspot.com)
pretreatment of rats with a PKA-selective small interference RNA (siRNA) mixture significantly attenuates sustained morphine-mediated augmentation of spinal CGRP immunoreactivity, thermal hyperalgesia, mechanical allodynia and antinociceptive tolerance. (blogspot.com)
Systemic administration of the TRPV1 antagonist SB-366791 markedly reduced both visceral pain behavior and referred somatic hyperalgesia in rats with CP, but not in control animals. (elsevier.com)

Amplification in the spinal cord may be another way of producing hyperalgesia. (wikipedia.org)
Another medication is buprenorphine, which can help to reduce the incidence of hyperalgesia by blocking receptors in the brain and spinal cord. (medicalnewstoday.com)
Electroacupuncture suppresses hyperalgesia and spinal Fos expression by activating the descending inhibitory system," Brain Research , vol. 1186, no. 1, pp. 171-179, 2007. (hindawi.com)
Involvement of spinal serotonin receptors in electroacupuncture anti-hyperalgesia in an inflammatory pain rat model," Neurochemical Research , vol. 36, no. 10, pp. 1785-1792, 2011. (hindawi.com)
They used brain imaging to characterize the circuits involved in nocebo hyperalgesia within the descending pain pathway from the prefrontal cortex to the spinal cord. (sciencemag.org)
Because nocebo hyperalgesia also modulates activity at the spinal level ( 14 ), we followed this lead and investigated whether nocebo hyperalgesia is mediated through interactions within a cortico-subcortico-spinal network ( 15 ), in analogy to other forms of cognitive pain modulation ( 16 , 17 ). (sciencemag.org)
To document potential mediating effects of the Activator-assisted spinal manipulative therapy (ASMT) on pain and hyperalgesia after acute intervertebral foramen (IVF) inflammation. (activator.com)
Hyperalgesia and Pain following Central Administration of SP(A) Paw withdrawal to radiant heat measured before and after administration of SP peptide to the lumbar spinal cord via an intrathecal cannula in lightly anesthetized animals (IT SP). (nih.gov)
Increases in PKC gamma expression in trigeminal spinal nucleus is associated with orofacial thermal hyperalgesia in streptozotocin-induced diabetic mice. (sigmaaldrich.com)
The association of cutaneous hyperalgesia with changes in the electrophysiological properties of DRG cells suggests a possible role for intrinsic alterations in the membrane properties of compressed DRG cells in the production and persistence of chronic pain after certain spinal injuries or pathologies of the spine. (biomedsearch.com)
The development and maintenance of secondary hyperalgesia depend on complex plastic changes in spinal cord dorsal horn cells after peripheral injury or damage. (knowcancer.com)
Most common chronic non-cancer illnesses causing hyperalgesia are failed back syndrome, degenerative disk disease , disk herniation , spinal stenosis , facet joint disease, fibromyalgia , hip or knee joint arthritis , intercostal neuralgia , post-herpetic neuralgia ( shingles ), diabetic neuropathy and peripheral neuropathy. (epainassist.com)
Hyperalgesia is caused by irritation of spinal nerve following back surgery. (epainassist.com)
Scar tissue following surgery often irritates or pinches spinal nerve resulting in hyperalgesia. (epainassist.com)
Hyperalgesia Caused Due To Pinched Nerve- Scar tissue, disk herniation, disk fragments and entrapped neuropathy causes continuous irritation or pinch of spinal or peripheral nerve, which results in hyperalgesia. (epainassist.com)
Multiple Sclerosis - Multiple sclerosis causes irritation of spinal nerve and results in wide spread hyperalgesia. (epainassist.com)
The results suggest that (1) spinal IL-17 is produced by astrocytes and enhances p-NR1 to facilitate inflammatory pain, and 2) EA inhibits hyperalgesia by suppressing IL-17. (biomedcentral.com)
A Comparison of the Effects of Burst and Tonic Spinal Cord Stimulation on Hyperalgesia and Physical Activity in an Animal Model of Neuropathic Pain. (painresearchforum.org)
The present study therefore investigated under in vivo conditions whether administration of lutein attenuates the inflammation-induced hyperexcitability of trigeminal spinal nucleus caudalis (SpVc) neurons that is associated with mechanical hyperalgesia. (biomedcentral.com)
Vera-Portocarrero LP, Zhang ET, King T, Ossipov MH, Vanderah TW, Lai J, Porreca F.Spinal NK-1 receptor expressing neurons mediate opioid-induced hyperalgesia and antinociceptive tolerance via activation of descending pathways // Pain 129: 35- 45, 2007. (org.ua)
Wei F, Dubner R, Ren K. Nucleus reticularis gigantocellularis and nucleus raphe magnus in the brain stem exert opposite effects on behavioral hyperalgesia and spinal Fos protein expression after peripheral inflammation // Pain. (org.ua)

Hyperalgesia is similar to other sorts of pain associated with nerve irritation or damage such as allodynia and neuropathic pain, and consequently may respond to standard treatment for these conditions, using various drugs such as SSRI or tricyclic antidepressants, Nonsteroidal anti-inflammatory drugs (NSAIDs), glucocorticoids, gabapentin or pregabalin, NMDA antagonists, or atypical opioids such as tramadol. (wikipedia.org)
Hyperalgesia is considered a form of neuropathic pain. (medicalnewstoday.com)
11,14 Furthermore, depletion of monocytes/macrophages ameliorates hyperalgesia in chemically induced peritonitis (acid-induced writhing) 15 and in neuropathic pain models. (asahq.org)
Neuropathic pain causes hyperalgesia. (epainassist.com)
Neuropathic pain is described as hyperalgesia and allodynia. (epainassist.com)
The cause of hyperalgesia pain is neuropathic pain. (epainassist.com)
Initial back pain is nociceptive pain and become neuropathic pain when symptoms of hyperalgesia become predominant. (epainassist.com)
Hyperalgesia induced by opioid is different than hyperalgesia caused by neuropathic pain. (epainassist.com)
We used CCK(2) receptor deficient (CCK(2) (-/-)) mice and assessed their mechanical sensitivity using Von Frey filaments, as well as the development and time course of mechanical hyperalgesia in a model of neuropathic pain. (edu.au)
Next, we found that CCK(2) (-/-) mice did not develop mechanical hyperalgesia in the Bennett's neuropathic pain model. (edu.au)
Neuropathic pain is characterized by both negative symptoms and positive symptoms including hyperalgesia, allodynia, paresthesia and spontaneous pain [1] . (plos.org)

The chief symptom of hyperalgesia is an increasingly extreme reaction to painful stimuli without any new injuries or worsening of a medical condition. (medicalnewstoday.com)
A pressure algometer and standardized monofilaments or weighted pinprick stimuli are used for assessing pressure and punctate allodynia and hyperalgesia and a thermal tester is used for thermal testing. (wikipedia.org)
Summary The principle finding of the present study is that there are two types of mechanical hyperalgesia developing in human hairy skin following injurious stimuli. (ovid.com)
Mechanical hyperalgesia comprises a dynamic component (brush-evoked pain, allodynia) signalled by large myelinated afferents and a static component (hyperalgesia to pressure stimuli) signalled by unmyelinated afferents. (ovid.com)
Both substances evoked burning pain and hyperalgesia to mechanical stimuli. (ovid.com)
In all mammals, tissue inflammation leads to pain and behavioral sensitization to thermal and mechanical stimuli called hyperalgesia. (nih.gov)
We found that the LIM motif-containing protein kinases (LIMKs), which regulate actin dynamics, promoted the development of inflammatory hyperalgesia (excessive sensitivity to painful stimuli). (sciencemag.org)
However, experimental studies report that opioids may also elicit hyperalgesia (increased sensitivity to noxious stimuli) and allodynia (nociceptive responses to innocuous stimulation). (asahq.org)
The immediate postoperative period is associated with spontaneous pain and hyperalgesia, i.e., increased pain response (both intensity and duration) to normally painful stimuli following tissue injury or damage. (knowcancer.com)
Hyperalgesia is increased feeling of pain after painful stimuli and allodynia is increased feeling of pain following non-painful stimuli like touch or pressure over skin. (epainassist.com)
Opioid induced hyperalgesia (OIH) is escalation of sensation of residual pain following both noxious and non-noxious stimuli. (epainassist.com)
We tested the hypotheses that PGE 2 -G is increased in DRGs of HbSS-BERK mice and sensitizes nociceptors (sensory neurons that respond to noxious stimuli), and that blocking its synthesis would decrease hyperalgesia in HbSS-BERK mice. (umn.edu)
Instead'of being inhibited, responses to painful stimuli become augmented, a phenomenon known as stress-induced hyperalgesia (SIH). (grantome.com)

Secondary hyperalgesia describes pain sensitivity that occurs in surrounding undamaged tissues. (wikipedia.org)
Various studies of humans and animals have demonstrated that primary or secondary hyperalgesia can develop in response to both chronic and acute exposure to opioids. (wikipedia.org)
Doctors usually divide hyperalgesia into primary and secondary categories. (medicalnewstoday.com)
Also, as a secondary outcome, in a group than will not receive the study drug, we will evaluate the temporal changes in opioid induced hyperalgesia, by pain sensitivity measured in the postoperative hours 2, 4 and 24. (clinicaltrials.gov)
This fMRI study observed that the mPFC is specifically active during pain perception resulting from secondary hyperalgesia, which arises from traumatized tissue. (jneurosci.org)
Secondary hyperalgesia is generally defined as the development of a heightened sensitivity to normal mechanical stimulation in uninjured skin surrounding an injury. (jneurosci.org)
It is well established that the mechanisms generating secondary hyperalgesia lie within the CNS as opposed to the peripheral mechanisms responsible for inducing primary hyperalgesia, i.e., hypersensitivity at the site of trauma ( Maihöfner and Handwerker, 2005 ). (jneurosci.org)
The authors of this study used a balanced design that used electrical stimulation to induce trauma, normally benign pin pricks to assess hyperalgesia, and subsequent intravenous application of lidocaine, a potent analgesic, to block perception of secondary hyperalgesia in normal participants undergoing fMRI scanning. (jneurosci.org)
Under these conditions, the mPFC (as well as the posterior cingulate, another major hub of the DMN) showed a robust response during the perception of secondary hyperalgesia but not primary hyperalgesia (i.e., no mPFC responses were detected during pin-prick stimulation at the site of the electrical trauma). (jneurosci.org)
Moreover, a significant negative correlation was found between the magnitude of mPFC (but not posterior cingulate) BOLD response and the size of secondary hyperalgesia response under placebo. (jneurosci.org)
That is, individuals with high levels of mPFC during periods of evoked secondary hyperalgesia pain had a smaller surface area of uninjured responsive skin during psychophysical testing and individuals with low levels of mPFC activity had a larger area of responsive skin. (jneurosci.org)
A secondary hyperalgesia is one in which the pain sensitivity occurs in surrounding undamaged tissues. (biology-online.org)
This component of mechanical hyperalgesia persisted for at least 30 min and was present in the skin exposed to the irritants (primary hyperalgesia) as well as in a zone of untreated skin surrounding the injury (secondary hyperalgesia) measuring 38 ± 4 cm 2 after capsaicin. (ovid.com)
Recently, we showed that knee joint manipulation decreases secondary mechanical hyperalgesia in the paw induced by injection of capsaicin into the ankle joint in rat (Sluka and Wright, 2001). (chiro.org)
Thermal thresholds for cold and hot sensation and for pain (by limit method) were evaluated at the site of skin incision (primary-) and distantly (secondary hyperalgesia). (springer.com)
Conclusions: Compared with placebo, DM enabled reduction of postoperative analgesics consumption, improved well-being, and reduced sedation, pain intensity and primary and secondary thermal hyperalgesia. (springer.com)
Mechanical hyperalgesia surrounding the wound in postoperative patients shares the same central neuronal mechanism as heat-induced secondary hyperalgesia and confirms a degree of central sensitization. (asahq.org)
Central sensitization is expressed behaviorally as secondary hyperalgesia and contributes to prolonged postoperative pain. (knowcancer.com)
In humans, NMDA-receptor antagonism decreases secondary hyperalgesia subsequent to experimentally-induced pain. (knowcancer.com)
Burns D, Hill L, Essandoh M, Jarzembowski TM, Schuler HG, Janicki PK, Effect of valdecoxib pretreatment on pain and secondary hyperalgesia: a randomized controlled trial in healthy volunteers [ISRCTN05282752, NCT00260325]. (isrctn.com)
Assess age differences in the intensity and course of secondary hyperalgesia after surgery. (isrctn.com)
Raja, S. N., Campbell, J. N., and Meyer, R. A., "Evidence for Different Mechanisms of Primary and Secondary Hyperalgesia Following Heat Injury to the Glabrous Skin" // Brain 107, 1179-1188 (1984). (org.ua)

OBJECTIVE Morbid obesity may be accompanied by diabetes and painful diabetic neuropathy, a poorly understood condition that is manifested by mechanical or thermal allodynia and hyperalgesia. (diabetesjournals.org)
A common complication of diabetes is peripheral diabetic neuropathy (PDN), which is often marked by mechanical and thermal allodynia and hyperalgesia and cannot yet be treated effectively because of the lack of knowledge of its pathophysiology ( 2 , 3 ). (diabetesjournals.org)
13 Also, it is possible to use periincisional mechanical allodynia and hyperalgesia as objective measures of opioid-induced hyperalgesia in clinical settings. (asahq.org)
Therefore, we tested the hypothesis that relatively large intraoperative doses of remifentanil provoke postoperative hyperalgesia as indicated by periincisional allodynia and hyperalgesia and that small-dose ketamine prevents hyperalgesia. (asahq.org)

Opioid-induced hyperalgesia may develop as a result of long-term opioid use in the treatment of chronic pain. (wikipedia.org)
Long-term opioid (e.g. heroin, morphine) users and those on high-dose opioid medications for the treatment of chronic pain, may experience hyperalgesia and experience pain out of proportion to physical findings, which is a common cause for loss of efficacy of these medications over time. (wikipedia.org)
Where hyperalgesia has been produced by chronic high doses of opioids, reducing the dose may result in improved pain management. (wikipedia.org)
These data support a major role for V(3) receptors in repeated psychological stress-induced visceral hyperalgesia and suggest that pharmacological manipulation of the AVP/V(3) pathway might represent an attractive alternative to the CRF/CRF(1) pathway for the treatment of chronic stress-related gastrointestinal disorders. (nih.gov)
Opioid treatments of chronic pain followed by opioid withdrawals may lead to hyperalgesia. (biology-online.org)
It was found that chronic morphine administration produced hyperalgesia between 60 and 120 minutes after the drug. (aspetjournals.org)
Mechanical and thermal hyperalgesia and ectopic neuronal discharge after chronic compression of dors. (biomedsearch.com)
We have recently demonstrated, in a model of chronic widespread pain, that prolonged enhancement of immune mediator hyperalgesia, induced by unpredictable sound stress, requires a contribution of both the sympathoadrenal (epinephrine) and the hypothalamic-pituitary adrenal (corticosterone) neuroendocrine stress axes. (pubmedcentralcanada.ca)
Neuroimmune activation and neuroinflammation in chronic pain and opioid tolerance/hyperalgesia. (semanticscholar.org)
What Are The Different Causes Of Hyperalgesia Associated With Chronic Pain? (epainassist.com)
Although some key pathways have been identified, further mechanistic work is necessary to fully characterize the mechanisms for the development of hyperalgesia following chronic exposure to ethanol. (unthsc.edu)
Background & Aims: The neurobiologic basis of pancreatic hyperalgesia in chronic pancreatitis (CP) is understood poorly and there is a need to identify novel therapeutic targets. (elsevier.com)

Our goal is to demonstrate that healthy volunteers treated with fenobam will develop a significantly reduced area of cutaneous hyperalgesia compared to volunteers treated with placebo, after exposure to the heat/capsaicin model of cutaneous sensitization. (clinicaltrials.gov)
A Double Blind, Randomized, Placebo Controlled, Crossover Study to Investigate the Anti-hyperalgesic Efficacy of a Single Dose of Fenobam on Heat/Capsaicin Induced Cutaneous Hyperalgesia in Adult Healthy Volunteers. (clinicaltrials.gov)
Suppression of the development of cutaneous hyperalgesia and allodynia around the area treated with heat/capsaicin. (clinicaltrials.gov)
After establishment, adrenal medullectomy abolished the enhancement of epinephrine-induced cutaneous and muscle hyperalgesia. (pubmedcentralcanada.ca)
Hardy JD, Wolff HG, Goodell H. Experimental evidence on the nature of cutaneous hyperalgesia. (org.ua)
In addition to cutaneous hyperalgesia, cisplatin treatment might also induce muscle hyperalgesia associated with upregulations of P2X3 and ASIC3. (blogspot.com)

The focal form is typically associated with injury, and is divided into two subtypes: Primary hyperalgesia describes pain sensitivity that occurs directly in the damaged tissues. (wikipedia.org)
Primary hyperalgesia describes pain sensitivity that occurs directly in the damaged tissues. (wikipedia.org)
While placebo hypoalgesia refers to decreased pain sensitivity due to an inert treatment (e.g., sham procedure and inert substance), its counterpart nocebo hyperalgesia is defined as increased pain sensitivity attributable to an inert treatment [ 2 ]. (hindawi.com)
The use of morphine, the standard opioid drug, is limited by its undesirable effects, such as tolerance, physical dependence, and hyperalgesia (increased pain sensitivity). (frontiersin.org)
Because the NMDA receptor antagonist dizocilpine maleate (MK-801) prevented both heroin-induced long-lasting enhancement in pain sensitivity and naloxone-precipitated hyperalgesia, these findings further suggest that tolerance, sensitization, and one withdrawal symptom, hyperalgesia, are issued from a neuroadaptive process in which NMDA systems play a critical role. (jneurosci.org)
A primary hyperalgesia is a type of hyperalgesia in which the pain sensitivity occurs directly in the damaged tissues. (biology-online.org)

Hyperalgesia from opioids is caused by a number of biological factors in the body. (opiates.com)
The use of opioids is commonly associated with opioid tolerance (OT) and opioid-induced hyperalgesia (OIH), which limit efficacy and compromise safety. (cellmedicine.com)
You may feel hyperalgesia induced by opioids. (epainassist.com)
Hyperalgesia has been observed during ethanol withdrawal, comparable to the hyperalgesia observed during withdrawal from opioids. (unthsc.edu)
Although common concerns regarding the use of opioids include the potential for detrimental side effects, physical dependence, and addiction, accumulating evidence suggests that opioids may yet cause another problem, often referred to as opioid-induced hyperalgesia. (scienceopen.com)

What Is Visceral Hyperalgesia? (cincinnatichildrens.org)
Visceral hyperalgesia is an increased sensitivity to pain in the internal organs of the body, like the stomach, pancreas or intestines. (cincinnatichildrens.org)
What Are Symptoms of Visceral Hyperalgesia? (cincinnatichildrens.org)
How Is Visceral Hyperalgesia Diagnosed? (cincinnatichildrens.org)
There is no specific test to diagnose visceral hyperalgesia. (cincinnatichildrens.org)
Widespread hyperalgesia in irritable bowel syndrome is dynamically maintained by tonic visceral impulse input and placebo/nocebo factors. (greenmedinfo.com)
Repeated administration of SSR149415 at 1 or 3 mg/kg completely prevented stress-induced visceral hyperalgesia. (nih.gov)
Visceral hyperalgesia is an higher sensitivity of the organs inside the body. (epnet.com)
Available at: http://www.cincinnatichildrens.org/health/v/visceral-hyperalgesia. (epnet.com)

These findings indicate that SAP102 can anchor NMDA receptors to affect hyperalgesia formation in bone cancer pain. (medworm.com)
Among the potential mechanisms leading to opioid-induced hyperalgesia and antinociceptive tolerance, N -methyl-d-aspartate (NMDA) pain-facilitator processes seem to play a key role. (asahq.org)
14,15 Experimental studies performed in animals and volunteers have shown that NMDA receptor antagonists such as ketamine inhibit central sensitization and prevent opioid-induced hyperalgesia. (asahq.org)
In animal models of pain, NMDA agonists induce central sensitization and hyperalgesia whereas antagonists decrease or prevent hyperalgesia. (knowcancer.com)
Our primary aim is to determine whether perioperative NMDA-receptor antagonism has differential effects on postoperative pain, hyperalgesia and morbidity in younger and older patients. (isrctn.com)

Ketamine pretreatment, which had no analgesic effect on its own, enhanced the earlier response (analgesia) and prevented the development of long-lasting hyperalgesia. (nih.gov)

This type of hyperalgesia is when the increased pain occurs in the tissue where the injury took place. (medicalnewstoday.com)
It is in regard to this type of hyperalgesia that homoeopathy can provide adequate and effective treatment for the affected person. (homeopathyguide.net)

The objective of this work is to evaluate the efficacy of propranolol in the modulation of opioid induced hyperalgesia, with lower postoperative requirements of analgesia rescue. (clinicaltrials.gov)
Preemptive hyperalgesia, not analgesia? (nih.gov)
The i.t injection of extracellular signal-regulated kinase (ERK) inhibitor blocked morphine-induced analgesia, without interfering with the morphine-induced hyperalgesia. (frontiersin.org)
However, whether a single systemic administration of an intermediate opioid dose (i.e., a dose that induces analgesia without compromising the overall activity, such as, locomotion or respiratory functions) induces hyperalgesia is still controversial. (frontiersin.org)
1-5 In some, opioid-induced hyperalgesia was observed to follow analgesia and lasted long after opioid exposure ended. (asahq.org)
Nocebo hyperalgesia has received sparse experimental attention compared to placebo analgesia. (uit.no)

These findings demonstrate that the model of short access to nicotine self-administration has limited validity for tobacco dependence, highlight the translational relevance of the model of extended-intermittent access to nicotine self-administration for tobacco dependence and demonstrate that activation of CRF1 receptors is required for the emergence of abstinence-induced anxiety-like behavior, hyperalgesia and excessive nicotine intake. (sigmaaldrich.com)
Bradykinin receptors antagonists and nitric oxide synthase inhibitors in vincristine and streptozotocin induced hyperalgesia in chemotherapy and diabetic neuropathy rat model. (nel.edu)
The results of this paper confirm that inhibition of bradykinin receptors and inducible NO synthase but not neuronal NO synthase activity reduces diabetic hyperalgesia. (nel.edu)
The prolonged opioid treatment often causes physiological changes in pain receptors and synapses resulting in hyperalgesia. (epainassist.com)
1 Activation of glial cells results in a pro-inflammatory state of pain receptors, which results in magnification of pain impulses expressing hyperalgesia. (epainassist.com)
Adenosine receptors, calcium channels, and protein kinase C appear to play central roles in mediating tolerance to antinociceptive effects of ethanol and mediating the hyperalgesia seen during withdrawal. (unthsc.edu)

Furthermore, varenicline (0.1 and 0.5 mg/kg) reversed nicotine withdrawal signs such as hyperalgesia and somatic signs and withdrawal-induced aversion in a dose-related manner. (rti.org)
There were significantly negative correlations between serum PEP activity and severity of pressure hyperalgesia and the non-somatic, cognitive symptoms of the Hamilton Depression Rating Scale. (prohealth.com)
In contrast, hyperalgesia in muscle is caused by somatic efferents in this view. (pharmacologicalsciences.us)

As it can be difficult to distinguish from tolerance, opioid-induced hyperalgesia is often compensated for by escalating the dose of opioid, potentially worsening the problem by further increasing sensitivity to pain. (wikipedia.org)
Hyperalgesia is different from tolerance to medications although the two processes are similar. (medicalnewstoday.com)
Drug tolerance is different from hyperalgesia, where increasing pain medication will not reduce the amount of pain a person feels. (medicalnewstoday.com)
A literature search was conducted from October 1995 through January 2015 using MEDLINE, Embase, and Scopus with the terms hyperalgesia, fentanyl, pronociceptive, acute tolerance, and acute. (nih.gov)
3,5 Opioid-induced processes that underlie hyperalgesia decrease antinociception and contribute to opioid tolerance. (asahq.org)

Erythromelalgia(heat hyperalgesia) is in part due to mutations in TTX sensitivity of channel Na 1.7 (Sodium 1.7). (dailystrength.org)
Manipulations that reduced LIMK activity or abundance, prevented the phosphorylation of cofilin, or disrupted actin filaments in DRG neurons attenuated CFA-induced heat hyperalgesia. (sciencemag.org)

In this review, we focus on the contribution of conditioning in the induction of placebo hypoalgesia and nocebo hyperalgesia and present accumulating evidence that conditioning independent from explicit expectation can cause these effects. (hindawi.com)
After giving a brief overview over current evidence and models on the development of placebo hypoalgesia and nocebo hyperalgesia including conditioning and expectation approaches, we will turn to studies that stress the significance of conditioning and demonstrate that conditioning effects might have been misunderstood and/or underestimated. (hindawi.com)
Labeling an inert treatment as expensive medication led to stronger nocebo hyperalgesia than labeling it as cheap medication. (sciencemag.org)
In particular, activity in the prefrontal cortex mediated the effect of value on nocebo hyperalgesia. (sciencemag.org)
The aim of the present study was to investigate if personality traits and fear of pain could predict experimental nocebo hyperalgesia. (uit.no)
The results from the present study suggest that dispositional fear of pain might be a useful predictor for nocebo hyperalgesia and emotional states concomitant with expectations of increased pain. (uit.no)

A new animal model for assessing mechanisms and management of muscle hyperalgesia // Pain 85: 333-343, 2000. (org.ua)

This lidocaine-induced sensitization might contribute to postoperative hyperalgesia. (uzh.ch)

Previous studies demonstrated that electroacupuncture (EA) alleviates hyperalgesia, but the mechanisms remained unclear. (biomedcentral.com)

The parallel fluctuation of brush-evoked and burning background pain therefore suggest that on-going activity from nociceptors is required to maintain a central state that permits dynamic mechanical hyperalgesia to be expressed in humans. (ovid.com)

Two trials oppose whereas four trials support the occurrence of fentanyl-induced hyperalgesia. (nih.gov)
The higher the fentanyl dose used, the more pronounced was the fentanyl-induced hyperalgesia. (nih.gov)

Blockage of P2X7R at the DRG reduced the mechanical hyperalgesia induced by CFA, and prevented the mechanical hyperalgesia induced by carrageenan or IL-1β, but not PGE 2 . (frontiersin.org)
Upregulations of TRPV2, P2X3 and ASIC3 may play important roles in the mechanical hyperalgesia induced by cisplatin. (blogspot.com)

17 However, we did not study the action of ketamine and specially the effects of ketamine on remifentanil-induced hyperalgesia in the postoperative setting, which have yet to be evaluated. (asahq.org)
The aim of this prospective, randomized, placebo-controlled study was to compare the effects of ketamine and paracetamol on preventing remifentanil induced hyperalgesia. (medsci.org)
It was shown that ketamine and paracetamol were both effective in preventing remifentanil induced hyperalgesia. (medsci.org)
Yalcin N, Uzun ST, Reisli R, Borazan H, Otelcioglu S. A Comparison of Ketamine and Paracetamol for Preventing Remifentanil Induced Hyperalgesia in Patients Undergoing Total Abdominal Hysterectomy. (medsci.org)

Importantly, at this stage of the block, when only unmyelinated primary afferents conducted, neither spontaneous pain, nor hyperalgesia to heat, nor the lowered pressure pain threshold had changed significantly. (ovid.com)

Here, we show that both magnitude and duration of heroin-induced delayed hyperalgesia increase with intermittent heroin administrations, leading to an apparent decrease in the analgesic effectiveness of a given heroin dose. (jneurosci.org)
According to some authors, hyperalgesia and related phenomena at skin level are induced by sympathetic efferents, because an experimental, local anesthetic block of the sympathetic ganglia led to disappearance or marked decrease of referred pain, hyperalgesia, and dermographic skin alterations. (pharmacologicalsciences.us)

Opioid-induced hyperalgesia is a phenomenon defined by increasing pain after opioid exposure with the worsening of pain occurring when opioid doses are increased. (nih.gov)
7 Moreover, delayed hyperalgesia develops from short-acting opioid exposure, 8-10 and relatively large intraoperative opioid doses are associated with greater postoperative opioid consumption and higher pain scores. (asahq.org)

Different types of hyperalgesia exist, and doctors have a variety of theories regarding why people experience hyperalgesia. (medicalnewstoday.com)
Some types of hyperalgesia may result in severe pain caused by the slightest body movement or the stimulation of a proprioceptor (bones, muscles, ligaments, joints). (homeopathyguide.net)
But there also are other types of hyperalgesia that affect organs like the stomach, liver, kidneys and even the intestines. (homeopathyguide.net)

Models and Mechanisms of Hyperalgesia and Allodynia // Physiolo. (org.ua)

When the ability to perceive light touch had been abolished, there was also no touch-evoked pain, indicating that this component of mechanical hyperalgesia is mediated by large-diameter primary afferents. (ovid.com)

Corneal Mechanical Hypersensitivity is Correlated with Wind Hyperalgesia, Ocular Symptoms, and Systemic Complaints. (arvojournals.org)
A multivariable linear regression model found that age and self-reported wind hyperalgesia were the variables most closely associated with detection and pain thresholds, after accounting for ocular symptoms, signs, and systemic co-morbidities. (arvojournals.org)
Description of hyperalgesia is distinct from symptoms of allodynia. (epainassist.com)
Symptoms of Opioid induced hyperalgesia (OIH) were thought to be more common in long-term opioid therapy. (epainassist.com)

Stress markedly exacerbates pain in diseases such as fibromyalgia and rheumatoid arthritis 1 - 4 , 8 , and we have hypothesized that stress causes generalized hyperalgesia by enhancing pronociceptive effects of immune mediators (e.g. cytokines and prostaglandins). (pubmedcentralcanada.ca)
In streptozotocin-induced hyperalgesia, inducible NO synthase participates in pronociceptive activity of bradykinin, whereas in vincristine-induced hyperalgesia bradykinin seemed to activate neuronal NO synthase pathway. (nel.edu)

Prolonged Differential Wound Hyperalgesia After an Interval. (lww.com)
We assessed postoperative pain at rest and with movement along with wound hyperalgesia in a patient who had undergone lower abdominal surgery under general anesthesia with a unilateral epidural block that persisted throughout surgery and in whom the epidural catheter was replaced immediately afterward. (lww.com)
Pain and wound hyperalgesia were consistently greater on the "unblocked" side for the 3-wk period of observation. (lww.com)

PGE 2 -G is known to produce hyperalgesia. (umn.edu)

Anatomy18

Organisms5

Diseases25

Chemicals and Drugs46

Analytical, Diagnostic and Therapeutic Techniques and Equipment11

Psychiatry and Psychology7

Phenomena and Processes11

Technology, Industry, Agriculture1

Health Care2

Cardiovascular and neuronal responses to head stimulation reflect central sensitization and cutaneous allodynia in a rat model of migraine. (1/2095)

Cytokine-mediated inflammatory hyperalgesia limited by interleukin-4. (2/2095)

The effects of inflammation and inflammatory mediators on nociceptive behaviour induced by ATP analogues in the rat. (3/2095)

Role of protein kinase A in the maintenance of inflammatory pain. (4/2095)

Primary and secondary hyperalgesia in a rat model for human postoperative pain. (5/2095)

The novel analgesic compound OT-7100 (5-n-butyl-7-(3,4,5-trimethoxybenzoylamino)pyrazolo[1,5-a]pyrimid ine) attenuates mechanical nociceptive responses in animal models of acute and peripheral neuropathic hyperalgesia. (6/2095)

Nitric oxide mediates the central sensitization of primate spinothalamic tract neurons. (7/2095)

Epinephrine produces a beta-adrenergic receptor-mediated mechanical hyperalgesia and in vitro sensitization of rat nociceptors. (8/2095)

Hyperalgesia

Pain Threshold

Nociceptors

Pain Measurement

Carrageenan

Pain

Injections, Spinal

Physical Stimulation

Analgesics

Rats, Sprague-Dawley

Capsaicin

Freund's Adjuvant

Hot Temperature

Neuralgia

Spinal Cord

Ganglia, Spinal

TRPV Cation Channels

Analgesics, Opioid

Touch

Posterior Horn Cells

Morphine

Mustard Plant

Sciatic Neuropathy

Hyperesthesia

Disease Models, Animal

Inflammation

Behavior, Animal

Nociception

Pain, Referred

Spinal Nerves

Sensory Receptor Cells

Drug Tolerance

Visceral Pain

Cyclohexanecarboxylic Acids

Sciatic Nerve

Foot

Edema

Nerve Fibers, Unmyelinated

Reflex, Abdominal

Peripheral Nervous System Diseases

Analgesia

Neurons, Afferent

Sensory System Agents

Hindlimb

Analgesics, Non-Narcotic

Visceral Afferents

Receptors, Neurokinin-1

Dose-Response Relationship, Drug

Receptors, N-Methyl-D-Aspartate

Rats, Wistar

Injections, Intradermal

Substance P

Ketamine

Viscera

Narcotic Antagonists

Dinoprostone

Naloxone

Nerve Growth Factor

Formaldehyde

Trigeminal Caudal Nucleus

Neurokinin-1 Receptor Antagonists

Medulla Oblongata

Peripheral Nerve Injuries

Mononeuropathies

Amines

Opioid Peptides

Receptors, Opioid, mu

Piperidines

Nerve Compression Syndromes

Pain, Postoperative

Facial Pain

Lidocaine

Calcitonin Gene-Related Peptide

Alcoholic Neuropathy

Diabetic Neuropathies

Dizocilpine Maleate

Receptor, PAR-2

Electroacupuncture

Myalgia

Excitatory Amino Acid Antagonists