OrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and Processes
HydroxyureaAntisickling AgentsAnemia, Sickle CellFetal HemoglobinNucleic Acid Synthesis InhibitorsRibonucleotide ReductasesDNA ReplicationPolycythemia VeraPipobromanS PhaseGuanazoleThrombocythemia, EssentialAphidicolinThymidineCytarabineDNA DamageCell CycleDeoxyribonucleotidesMethyl MethanesulfonateHemoglobin, SickleCell Cycle ProteinsCheckpoint Kinase 2SchizosaccharomycesDNADidanosinebeta-ThalassemiaDrug OverdoseAlcohol DrinkingPregnancyAlcoholsPregnancy Complications
Hydroxyurea
An antineoplastic agent that inhibits DNA synthesis through the inhibition of ribonucleoside diphosphate reductase.
Antisickling Agents
Agents used to prevent or reverse the pathological events leading to sickling of erythrocytes in sickle cell conditions.
Anemia, Sickle Cell
A disease characterized by chronic hemolytic anemia, episodic painful crises, and pathologic involvement of many organs. It is the clinical expression of homozygosity for hemoglobin S.
Fetal Hemoglobin
The major component of hemoglobin in the fetus. This HEMOGLOBIN has two alpha and two gamma polypeptide subunits in comparison to normal adult hemoglobin, which has two alpha and two beta polypeptide subunits. Fetal hemoglobin concentrations can be elevated (usually above 0.5%) in children and adults affected by LEUKEMIA and several types of ANEMIA.
Nucleic Acid Synthesis Inhibitors
Compounds that inhibit cell production of DNA or RNA.
Ribonucleotide Reductases
DNA Replication
The process by which a DNA molecule is duplicated.
Polycythemia Vera
A myeloproliferative disorder of unknown etiology, characterized by abnormal proliferation of all hematopoietic bone marrow elements and an absolute increase in red cell mass and total blood volume, associated frequently with splenomegaly, leukocytosis, and thrombocythemia. Hematopoiesis is also reactive in extramedullary sites (liver and spleen). In time myelofibrosis occurs.
Pipobroman
An antineoplastic agent that acts by alkylation.
S Phase
Phase of the CELL CYCLE following G1 and preceding G2 when the entire DNA content of the nucleus is replicated. It is achieved by bidirectional replication at multiple sites along each chromosome.
Guanazole
A cytostatic triazole derivative which is not to be confused with guanazolo, the generic name for 8-azaguanine.
Thrombocythemia, Essential
A clinical syndrome characterized by repeated spontaneous hemorrhages and a remarkable increase in the number of circulating platelets.
Aphidicolin
An antiviral antibiotic produced by Cephalosporium aphidicola and other fungi. It inhibits the growth of eukaryotic cells and certain animal viruses by selectively inhibiting the cellular replication of DNA polymerase II or the viral-induced DNA polymerases. The drug may be useful for controlling excessive cell proliferation in patients with cancer, psoriasis or other dermatitis with little or no adverse effect upon non-multiplying cells.
Thymidine
Cytarabine
A pyrimidine nucleoside analog that is used mainly in the treatment of leukemia, especially acute non-lymphoblastic leukemia. Cytarabine is an antimetabolite antineoplastic agent that inhibits the synthesis of DNA. Its actions are specific for the S phase of the cell cycle. It also has antiviral and immunosuppressant properties. (From Martindale, The Extra Pharmacopoeia, 30th ed, p472)
DNA Damage
Injuries to DNA that introduce deviations from its normal, intact structure and which may, if left unrepaired, result in a MUTATION or a block of DNA REPLICATION. These deviations may be caused by physical or chemical agents and occur by natural or unnatural, introduced circumstances. They include the introduction of illegitimate bases during replication or by deamination or other modification of bases; the loss of a base from the DNA backbone leaving an abasic site; single-strand breaks; double strand breaks; and intrastrand (PYRIMIDINE DIMERS) or interstrand crosslinking. Damage can often be repaired (DNA REPAIR). If the damage is extensive, it can induce APOPTOSIS.
Cell Cycle
The complex series of phenomena, occurring between the end of one CELL DIVISION and the end of the next, by which cellular material is duplicated and then divided between two daughter cells. The cell cycle includes INTERPHASE, which includes G0 PHASE; G1 PHASE; S PHASE; and G2 PHASE, and CELL DIVISION PHASE.
Deoxyribonucleotides
A purine or pyrimidine base bonded to a DEOXYRIBOSE containing a bond to a phosphate group.
Methyl Methanesulfonate
An alkylating agent in cancer therapy that may also act as a mutagen by interfering with and causing damage to DNA.
Hemoglobin, Sickle
An abnormal hemoglobin resulting from the substitution of valine for glutamic acid at position 6 of the beta chain of the globin moiety. The heterozygous state results in sickle cell trait, the homozygous in sickle cell anemia.
Cell Cycle Proteins
Proteins that control the CELL DIVISION CYCLE. This family of proteins includes a wide variety of classes, including CYCLIN-DEPENDENT KINASES, mitogen-activated kinases, CYCLINS, and PHOSPHOPROTEIN PHOSPHATASES as well as their putative substrates such as chromatin-associated proteins, CYTOSKELETAL PROTEINS, and TRANSCRIPTION FACTORS.
Checkpoint Kinase 2
Enzyme activated in response to DNA DAMAGE involved in cell cycle arrest. The gene is located on the long (q) arm of chromosome 22 at position 12.1. In humans it is encoded by the CHEK2 gene.
Schizosaccharomyces
A genus of ascomycetous fungi of the family Schizosaccharomycetaceae, order Schizosaccharomycetales.
DNA
A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine).
Didanosine
A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. Didanosine is a potent inhibitor of HIV replication, acting as a chain-terminator of viral DNA by binding to reverse transcriptase; ddI is then metabolized to dideoxyadenosine triphosphate, its putative active metabolite.
beta-Thalassemia
A disorder characterized by reduced synthesis of the beta chains of hemoglobin. There is retardation of hemoglobin A synthesis in the heterozygous form (thalassemia minor), which is asymptomatic, while in the homozygous form (thalassemia major, Cooley's anemia, Mediterranean anemia, erythroblastic anemia), which can result in severe complications and even death, hemoglobin A synthesis is absent.
Drug Overdose
Accidental or deliberate use of a medication or street drug in excess of normal dosage.
Alcohol Drinking
Behaviors associated with the ingesting of alcoholic beverages, including social drinking.
Pregnancy
The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
Alcohols
Alkyl compounds containing a hydroxyl group. They are classified according to relation of the carbon atom: primary alcohols, R-CH2OH; secondary alcohols, R2-CHOH; tertiary alcohols, R3-COH. (From Grant & Hackh's Chemical Dictionary, 5th ed)
Pregnancy Complications
Conditions or pathological processes associated with pregnancy. They can occur during or after pregnancy, and range from minor discomforts to serious diseases that require medical interventions. They include diseases in pregnant females, and pregnancies in females with diseases.

Caffeine can override the S-M checkpoint in fission yeast. (1/1655)

The replication checkpoint (or 'S-M checkpoint') control prevents progression into mitosis when DNA replication is incomplete. Caffeine has been known for some time to have the capacity to override the S-M checkpoint in animal cells. We show here that caffeine also disrupts the S-M checkpoint in the fission yeast Schizosaccharomyces pombe. By contrast, no comparable effects of caffeine on the S. pombe DNA damage checkpoint were seen. S. pombe cells arrested in early S phase and then exposed to caffeine lost viability rapidly as they attempted to enter mitosis, which was accompanied by tyrosine dephosphorylation of Cdc2. Despite this, the caffeine-induced loss of viability was not blocked in a temperature-sensitive cdc2 mutant incubated at the restrictive temperature, although catastrophic mitosis was prevented under these conditions. This suggests that, in addition to S-M checkpoint control, a caffeine-sensitive function may be important for maintenance of cell viability during S phase arrest. The lethality of a combination of caffeine with the DNA replication inhibitor hydroxyurea was suppressed by overexpression of Cds1 or Chk1, protein kinases previously implicated in S-M checkpoint control and recovery from S phase arrest. In addition, the same combination of drugs was specifically tolerated in cells overexpressing either of two novel S. pombe genes isolated in a cDNA library screen. These findings should allow further molecular investigation of the regulation of S phase arrest, and may provide a useful system with which to identify novel drugs that specifically abrogate the checkpoint control.  (+info)

Increased sensitivity of hydroxyurea-resistant leukemic cells to gemcitabine. (2/1655)

Tumor cell resistance to certain chemotherapeutic agents may result in cross-resistance to related antineoplastic agents. To study cross-resistance among inhibitors of ribonucleotide reductase, we developed hydroxyurea-resistant (HU-R) CCRF-CEM cells. These cells were 6-fold more resistant to hydroxyurea than the parent hydroxyurea-sensitive (HU-S) cell line and displayed an increase in the mRNA and protein of the R2 subunit of ribonucleotide reductase. We examined whether HU-R cells were cross-resistant to gemcitabine, a drug that blocks cell proliferation by inhibiting ribonucleotide reductase and incorporating itself into DNA. Contrary to our expectation, HU-R cells had an increased sensitivity to gemcitabine. The IC50 of gemcitabine was 0.061 +/- 0.03 microM for HU-R cells versus 0.16 +/- 0.02 microM for HU-S cells (P = 0.005). The cellular uptake of [3H]gemcitabine and its incorporation into DNA were increased in HU-R cells. Over an 18-h incubation with radiolabeled gemcitabine (0.25 microM), gemcitabine uptake was 286 +/- 37.3 fmol/10(6) cells for HU-R cells and 128 +/- 8.8 fmol/10(6) cells for HU-S cells (P = 0.03). The incorporation of gemcitabine into DNA was 75 +/- 6.7 fmol/10(6) cells for HU-R cells versus 22 +/- 0.6 fmol/10(6) cells for HU-S cells (P < 0.02). Our studies suggest that the increased sensitivity of HU-R cells to gemcitabine results from increased drug uptake by these cells. This, in turn, favors the incorporation of gemcitabine into DNA, resulting in enhanced cytotoxicity. The increased sensitivity of malignant cells to gemcitabine after the development of hydroxyurea resistance may be relevant to the design of chemotherapeutic trials with these drugs.  (+info)

RAD53 regulates DBF4 independently of checkpoint function in Saccharomyces cerevisiae. (3/1655)

The Cdc7p and Dbf4p proteins form an active kinase complex in Saccharomyces cerevisiae that is essential for the initiation of DNA replication. A genetic screen for mutations that are lethal in combination with cdc7-1 led to the isolation of seven lsd (lethal with seven defect) complementation groups. The lsd7 complementation group contained two temperature-sensitive dbf4 alleles. The lsd1 complementation group contained a new allele of RAD53, which was designated rad53-31. RAD53 encodes an essential protein kinase that is required for the activation of DNA damage and DNA replication checkpoint pathways, and that is implicated as a positive regulator of S phase. Unlike other RAD53 alleles, we demonstrate that the rad53-31 allele retains an intact checkpoint function. Thus, the checkpoint function and the DNA replication function of RAD53 can be functionally separated. The activation of DNA replication through RAD53 most likely occurs through DBF4. Two-hybrid analysis indicates that the Rad53p protein binds to Dbf4p. Furthermore, the steady-state level of DBF4 message and Dbf4p protein is reduced in several rad53 mutant strains, indicating that RAD53 positively regulates DBF4. These results suggest that two different functions of the cell cycle, initiation of DNA replication and the checkpoint function, can be coordinately regulated through the common intermediate RAD53.  (+info)

Sustained induction of fetal hemoglobin by pulse butyrate therapy in sickle cell disease. (4/1655)

High levels of fetal hemoglobin (Hb F) protect from many of the complications of sickle cell disease and lead to improved survival. Butyrate and other short chain fatty acids were previously shown to increase Hb F production in erythroid cells in vitro and in animal models in vivo. However, butyrates are also known to inhibit the proliferation of many cell types, including erythroid cells. Experience with the use of butyrate in animal models and in early clinical trials demonstrated that the Hb F response may be lost after prolonged administration of high doses of butyrate. We hypothesized that this loss of response may be a result of the antiproliferative effects of butyrate. We designed a regimen consisting of intermittent or pulse therapy in which butyrate was administered for 4 days followed by 10 to 24 days with no drug exposure. This pulse regimen induced fetal globin gene expression in 9 of 11 patients. The mean Hb F in this group increased from 7.2% to 21.0% (P <.002) after intermittent butyrate therapy for a mean duration of 29.9 weeks. This was associated with a parallel increase in the number of F cells and F reticulocytes. The total hemoglobin levels also increased from a mean of 7.8 g/dL to a mean of 8.8 g/dL (P <.006). The increased levels of Hb F were sustained in all responders, including 1 patient who has been on pulse butyrate therapy for more than 28 months. This regimen, which resulted in a marked and sustained increase in Hb F levels in more than two thirds of the adult sickle cell patients enrolled in this study, was well tolerated without adverse side effects. These encouraging results require confirmation along with an appropriate evaluation of clinical outcomes in a larger number of patients with sickle cell disease.  (+info)

Radiation therapy with concomitant hydroxyurea and fluorouracil in stage II and III head and neck cancer. (5/1655)

PURPOSE: In 1986, a multi-institutional phase II trial was begun to study the use of chemotherapy with concomitant radiation in patients with stage II and III head and neck cancer. End points were overall survival, progression-free survival, local/regional control, and toxicity in the setting of organ preservation with concomitant treatment. METHODS: Eligible patients with stage II or III disease received chemotherapy and radiation on a 2-week cycle. Chemotherapy consisted of continuous infusion fluorouracil (5-FU) at 800 mg/m2/d for 5 consecutive days (days 1 to 5) and hydroxyurea (HU) at 1 g orally every 12 hours for 13 doses starting the evening before the start of irradiation. Radiation therapy was given as single 1.8- to 2.0-Gy fractions for 5 consecutive days (days 1 to 5) with chemotherapy. Each 5 days of treatment was followed by a 9-day break (days 6 to 14), during which no additional treatment was given. Treatment cycles were repeated until the completion of the planned radiation dose (six to eight cycles). RESULTS: Between 1989 and 1996, 60 patients were enrolled. All patients were eligible for analysis, with a median follow-up of 52 months for surviving patients and 42 months for all patients. Grade 3 to 4 mucositis occurred in 57% of patients. The 5 year-actuarial overall survival, progression-free survival, and local/regional control were 65%, 82%, and 86%, respectively. Eight patients developed local and/or regional recurrence after treatment. Surgical salvage was possible in three of these patients. Thus, the ultimate 5-year local/ regional control was 91%. CONCLUSION: Concomitant radiation and chemotherapy with 5-FU and HU is an effective regimen in patients with stage II and III head and neck cancer. Progression-free survival and local/regional control appear to be superior to expected rates in patients treated with surgery and radiation. Further testing of this regimen in a phase III setting is indicated.  (+info)

Cell cycle-dependent sequencing of cell fate decisions in Caenorhabditis elegans vulva precursor cells. (6/1655)

In Caenorhabditis elegans, the fates of the six multipotent vulva precursor cells (VPCs) are specified by extracellular signals. One VPC expresses the primary (1 degrees ) fate in response to a Ras-mediated inductive signal from the gonad. The two VPCs flanking the 1 degrees cell each express secondary (2 degrees ) fates in response to lin-12-mediated lateral signaling. The remaining three VPCs each adopt the non-vulval tertiary (3 degrees ) fate. Here I describe experiments examining how the selection of these vulval fates is affected by cell cycle arrest and cell cycle-restricted lin-12 activity. The results suggest that lin-12 participates in two developmental decisions separable by cell cycle phase: lin-12 must act prior to the end of VPC S phase to influence a 1 degrees versus 2 degrees cell fate choice, but must act after VPC S phase to influence a 3 degrees versus 2 degrees cell fate choice. Coupling developmental decisions to cell cycle transitions may provide a mechanism for prioritizing or ordering choices of cell fates for multipotential cells.  (+info)

Randomized trial of zileuton in patients with moderate asthma: effect of reduced dosing frequency and amounts on pulmonary function and asthma symptoms. Zileuton Study Group. (7/1655)

This 6-month, randomized, multicenter study was designed to determine whether patients who had been treated with the leukotriene pathway inhibitor zileuton 600 mg four times daily (QID) for 2 months could be maintained at the same level of pulmonary function, symptom control, and beta-agonist use with less frequent dosing--first 600 or 800 mg three times daily (TID) and then twice daily (BID). A total of 278 patients with chronic asthma, ages 16 to 70, participated at 25 US centers. All had a 1-second forced expiratory volume (FEV1) of 35%-75%, reversible airway disease, and a nonsmoking history of 1 year. An 8-week open-label period (zileuton 600 mg QID) was followed by a 16-week double-blind period, in which patients who responded to the QID treatment were randomized to receive zileuton 600 or 800 mg TID for 8 weeks and then rerandomized to receive zileuton 600 or 800 mg BID for another 8 weeks. Primary outcomes were FEV1 and asthma symptom scores; secondary outcomes were peak expiratory flow rate, beta-agonist use, and asthma exacerbations requiring steroid rescue. Patients who showed improvements in lung function when treated with zileuton 600 mg QID demonstrated minimal decreases in FEV1 and comparable peak expiratory flow rates, symptom control, beta-agonist use, and systemic corticosteroid rescue when being treated with lower doses and/or less frequent doses of zileuton. Patients who demonstrate improved asthma control with zileuton 600 mg QID may be able to reduce their daily dosage and/or frequency while still maintaining the same level of symptom control.  (+info)

Safety and clinical efficacy of zileuton in patients with chronic asthma. (8/1655)

Zileuton, a leukotriene pathway inhibitor used to treat asthma, improves lung function, relieves symptoms, and is well tolerated. The purpose of this 12-month, parallel-group, open-label study was to assess the efficacy of zileuton and evaluate liver function in patients treated with this drug (approximately 2% of patients treated with zileuton in controlled trials had reversible liver enzyme elevations). A total of 2,947 patients at 233 centers in the United States were randomly assigned in a 5:1 ratio to treatment with zileuton plus usual asthma care or usual asthma care alone. Efficacy variables included asthma exacerbations; need for alternative treatment, steroid rescue, emergency care, and hospitalizations; forced expiratory volume in 1 second (FEV1); and asthma symptom scores. The safety evaluation included measurement of alanine aminotransferase levels. Patients treated with zileuton had significantly fewer corticosteroid rescues (P < 0.001), required less emergency care (P < 0.05), had fewer hospitalizations, and had greater increases in FEV1 (P = 0.048). They also had significantly greater improvements in asthma symptoms. Increases in alanine aminotransferase levels to three times or more the upper limit of normal occurred in 4.6% of patients treated with zileuton and 1.1% of those receiving usual care (P < 0.001); most increases occurred during the first 2 to 3 months. Alanine aminotransferase levels decreased to less than two times the upper limit of normal or to baseline levels during zileuton treatment or after drug cessation. Jaundice or chronic liver disease did not develop in any patient. Adding zileuton to the therapeutic regimens of patients with asthma is likely to improve asthma control and lower utilization of healthcare resources.  (+info)

Pharmacokinetics, pharmacodynamics, and pharmacogenetics of hydroxyurea treatment for children with sickle cell anemia | Blood ...Pharmacokinetics, pharmacodynamics, and pharmacogenetics of hydroxyurea treatment for children with sickle cell anemia | Blood ...
PD parameters were obtained after a standardized schedule of hydroxyurea dose escalation to MTD as previously described.2,13 Importantly, dose escalation to MTD for HUSTLE was performed by experienced health care providers who were masked to any knowledge about first-dose PK data. At MTD, both the average %HbF response and the average hydroxyurea dose were almost identical between the New and Old Cohort subjects and were similar to previously published data for children with SCA at hydroxyurea MTD.1,4,5 Predictors of the hydroxyurea treatment response, particularly the %HbF, have been previously proposed; in the original phase 1/2 trial for adults with SCA, the best HbF responses occurred in subjects with higher baseline HbF and baseline WBC count.5 In the phase 3 MSH study the best responses occurred in adults with higher baseline ANC and ARC, as well as those with greater treatment-associated changes in ANC and MCV, but baseline HbF was not predictive.35 In the phase 1/2 trial for school-aged ...
https://ashpublications.org/blood/article/118/18/4985/29325/Pharmacokinetics-pharmacodynamics-and
Therapeutic Potential of Nanoparticle-loaded Hydroxyurea on Proliferation of Human Breast Adenocarcinoma Cell LineTherapeutic Potential of Nanoparticle-loaded Hydroxyurea on Proliferation of Human Breast Adenocarcinoma Cell Line
Although hydroxyurea is one of the most widely used drugs in treating breast cancer, the use of it leads to some side effects. Hence, in order to reduce complications of treatment and increase its efficiency, drug delivery has been attracted more attention. Present study included three stages. The first stage was involved in the synthesis of nanoparticles-loaded hydroxyurea that its characteristics were evaluated by using scanning electron microscopy and Zetasizer system. In the second stage, cultured MCF-7 cells were undergone treatments by hydroxyurea and Nanoparticles-loaded hydroxyurea in various concentrations. In the third stage, the MCF-7 was treated by IC50 of hydroxyurea and nanoparticles-loaded hydroxyurea which are in combination with radiation and hyperthermia. Afterward, the viable of cell, apoptosis, and levels of caspase-8 and-9 proteins were assessed. The average size and the potential surface of nanoparticles and nanoparticles-loaded hydroxyurea were 26 nm, 48 nm, 3.86 mV, and -29.3 mV
http://ijpr.sbmu.ac.ir/article_1100921.html
Hydroxyurea-induced foot ulcer in a case of essential thrombocythaemia.
To illustrate the association between hydroxyurea and the development of ulcers. A case study is presented, in which histological changes, mean corpuscular volume (MCV) and transcutaneous oxygen tension (TcPO2) were all measured and analysed, b
http://www.biomedsearch.com/nih/Hydroxyurea-induced-foot-ulcer-in/20852510.html
Nitric oxide generation from hydroxyurea via copper-catalyzed peroxidation and implications for pharmacological actions of...
TY - JOUR. T1 - Nitric oxide generation from hydroxyurea via copper-catalyzed peroxidation and implications for pharmacological actions of hydroxyurea. AU - Sato, Keizo. AU - Akaike, Takaaki. AU - Sawa, Tomohiro. AU - Miyamoto, Yoichi. AU - Suga, Moritaka. AU - Ando, Masayuki. AU - Maeda, Hiroshi. PY - 1997/12. Y1 - 1997/12. N2 - We investigated the generation of nitric oxide (.NO) by H2O2-dependent peroxidation of hydroxyurea in the presence of copper-containing proteins such as Cu,Zn-superoxide dismutase (Cu,Zn-SOD) or ceruloplasmin as a catalyst. In the reaction mixture of hydroxyurea, Cu,Zn-SOD, and H2O2, .NO generation was identified by measuring the specific electron spin resonance (ESR) signal of 2-phenyl-4,4,5,5-tetramethylimidazoline-1-oxyl 3-oxide (PTIO). The ESR signal of the NO-hemoglobin adduct was also detected in human red blood cells during copper-catalyzed peroxidation of hydroxyurea. The .NO production during peroxidation of hydroxyurea was quantified as NO2- formation, ...
https://tohoku.pure.elsevier.com/ja/publications/nitric-oxide-generation-from-hydroxyurea-via-copper-catalyzed-per
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Hydrogen protects against cell death and senescence induced by oxidative damage | Molecular Hydrogen Studies
Hydrogen has potential for preventive and therapeutic applications as an antioxidant. However, micro- and macroparticles of hydrogen in water disappear easily over time. In order to eliminate reactive oxygen species (ROS) related with the aging process, the authors used functional water containing nanoparticle hydrogen. Nanoparticle hydrogen does not disappear easily and collapses under water for long periods of time. The study used murine embryonic fibroblasts that were isolated from 12.5-day embryos of C57BL/6 mice. The authors investigated the ability of nanoparticle hydrogen in water to suppress hydroxyurea-induced ROS production, cytotoxicity, and the accumulation of β-galactosidase (an indicator of aging), and promote cell proliferation. The accumulation of β-galactosidase in the cytoplasm and the appearance of abnormal nuclei were inhibited by daily treatment of cells with hydrogen water. When the aging process was accelerated by hydroxyurea-induced oxidative stress, the effect of ...
http://www.molecularhydrogenstudies.com/hydrogen-protects-against-cell-death-and-senescence-induced-by-oxidative-damage/
Altmetric - Hydroxyurea (hydroxycarbamide) for sickle cell disease
Sickle cell disease (SCD) is one of the most common inherited diseases worldwide. It is associated with lifelong morbidity and a reduced life expectancy. Hydroxyurea (hydroxycarbamide), an oral chemotherapeutic drug, ameliorates some of the clinical problems of SCD, in particular that of pain, by raising fetal haemoglobin. This is an update of a previously published Cochrane Review. To assess the effects of hydroxyurea therapy in people with SCD (all genotypes), of any age, regardless of setting. We searched the Cochrane Cystic Fibrosis and Genetic Disorders Group Haemoglobinopathies Register, comprising of references identified from comprehensive electronic database searches and handsearches of relevant journals and abstract books of conference proceedings. We also searched online trial registries.Date of the most recent search: 16 January 2017. Randomised and quasi-randomised controlled trials, of one month or longer, comparing hydroxyurea with placebo, standard therapy or other interventions ...
https://cochrane.altmetric.com/details/19233734
RESEARCHERS CONFIRM EFFECTIVENESS OF GLEEVEC PLUS HYDROXYUREARESEARCHERS CONFIRM EFFECTIVENESS OF GLEEVEC PLUS HYDROXYUREA
Researchers from the University of Pittsburgh, Duke University, and Dulman, Germany, have reported that the combination of Gleevec (imatinib mesylate) plus hydroxyurea provides benefit for approximately one-half of patients with recurrent glioblastoma multiforme.
https://www.fdanews.com/articles/83360-researchers-confirm-effectiveness-of-gleevec-plus-hydroxyurea
Untitled
Collagen synthesis by fi broblasts is critical in the healing of soft 1 Sirieix ME , Debure C , Baudot N et al. : Leg ulcers and hydroxyurea: tissue wounds. It is dependent on effi cient oxygen supply. forty-one cases . Arch Dermatol 1999 ; 135 (7) : 818 - 820 Hyperbaric oxygen stimulates fi broblast proliferation and differ- 2 Best PJ , Daoud MS , Pittelkow MR , Petitt RM : Hydroxyurea-induced leg ulceration in 14 patients . Ann Intern Med 1998 ; 128 (1) : 29 - 32 entiation, increases collagen formation and cross-linking, aug- 3 Kido M , Tago O , Fujiwara H , Ito M , Niwano H : Leg ulcer associated with ments neovascularization, and ameliorates leukocyte functions hydroxyurea treatment in a patient with chronic myelogenous leu- [8] . Hyperoxia can trigger the onset of signal transduction path- kaemia: successful treatment with prostagladin E1 and pentoxifylline . Br J Dermatol 1998 ; 139 (6) : 1124 - 1126 ways regulating the gene expression of growth factors. Oxygen 4 Aragane Y , Okamoto T , ...
http://pdfmedarticles.com/o/oxfordhbot.com1.html
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Hydroxyurea to Treat Beta-Thalassemia (Cooley's Anemia) - Full Text View - ClinicalTrials.govHydroxyurea to Treat Beta-Thalassemia (Cooley's Anemia) - Full Text View - ClinicalTrials.gov
This 12-month study will evaluate the safety and effectiveness of hydroxyurea in treating beta-thalassemia, a type of anemia caused by defective hemoglobin (the oxygen-carrying pigment in blood). Hemoglobin is composed of two protein chains-alpha globin chains and beta globin chains; patients with beta-thalassemia do not make beta globin. Patients often require frequent red blood cell transfusions. This leads to iron overload, which, in turn, requires iron chelation therapy (removal of iron from the blood).. Some drugs, including hydroxyurea, can stimulate production of a third type of protein chain called gamma chains. In the womb, the fetus makes this type of protein instead of beta globin. It is not until after birth, when the fetus no longer produces gamma globin that the beta globin deficiency becomes apparent. Gamma chain synthesis improves hemoglobin and red blood cell production, correcting the anemia. This study will determine if and at what dose hydroxyurea treatment reduces patients ...
https://clinicaltrials.gov/ct2/show/NCT00001958
Evidence review of hydroxyurea for the prevention of sickle cell complications in low-income countries.
Hydroxyurea is widely used in high-income countries for the management of sickle cell disease (SCD) in children. In Kenyan clinical guidelines, hydroxyurea is only recommended for adults with SCD. Yet many deaths from SCD occur in early childhood, deaths that might be prevented by an effective, disease modifying intervention. The aim of this review was to summarise the available evidence on the efficacy, effectiveness and safety of hydroxyurea in the management of SCD in children below 5 years of age to support guideline development in Kenya. We undertook a systematic review and used the Grading of Recommendations Assessment, Development and Evaluation system to appraise the quality of identified evidence. Overall, available evidence from 1 systematic review (n=26 studies), 2 randomised controlled trials (n=354 children), 14 observational studies and 2 National Institute of Health reports suggest that hydroxyurea may be associated with improved fetal haemoglobin levels, reduced rates of ...
http://erepository.uonbi.ac.ke:8080/xmlui/handle/11295/57722
Phase I pharmacodynamic study of time and sequence dependency of hydroxyurea in combination with gemcitabine: A California...
TY - JOUR. T1 - Phase I pharmacodynamic study of time and sequence dependency of hydroxyurea in combination with gemcitabine. T2 - A California cancer consortium trial. AU - Yen, Yun. AU - Chow, Warren. AU - Leong, Lucille. AU - Margolin, Kim. AU - Morgan, Robert. AU - Raschko, James. AU - Shibata, Stephen. AU - Somlo, George. AU - Twardowski, Przemyslaw. AU - Frankel, Paul. AU - Longmate, Jeff. AU - Synold, Timothy. AU - Newman, Edward M.. AU - Lenz, Heinz Josef. AU - Gandara, David. AU - Doroshow, James H.. PY - 2002/12/21. Y1 - 2002/12/21. N2 - Preclinical studies in our laboratory have demonstrated that prior exposure to hydroxyurea increases the percentage of cells in S phase, enhancing the cytotoxicity of subsequent gemcitabine treatment in human oropharyngeal KB cells. To evaluate the clinical implications of this time- and sequence-dependent potentiation, we performed a phase I trial of hydroxyurea given over 24 h followed by a 30-min infusion of gemcitabine in weeks 1 and 2 of a 3-week ...
https://tmu.pure.elsevier.com/zh/publications/phase-i-pharmacodynamic-study-of-time-and-sequence-dependency-of--2
Stroke With Transfusions Changing to Hydroxyurea - Full Text View - ClinicalTrials.govStroke With Transfusions Changing to Hydroxyurea - Full Text View - ClinicalTrials.gov
BACKGROUND:. Stroke occurs in 10% of children with SCA and has a very high risk of recurrence without therapy. Affected children receive chronic erythrocyte transfusions to prevent a secondary stroke, which are effective but have limited long-term utility due to transmission of infectious agents, erythrocyte alloantibody and autoantibody formation, and iron overload. Transfusion acquired iron overload can cause chronic organ damage with hepatic fibrosis and cirrhosis, poor growth and development, cardiac arrhythmias, and early sudden death in young patients with SCA and stroke. An alternative to transfusions for secondary stroke prevention that also addresses the issue of transfusion acquired iron overload is clearly needed. Hydroxyurea can prevent acute vaso-occlusive events in SCA, but its utility for cerebrovascular disease and for the prevention of secondary stroke in SCA is not proven. Pilot data indicate hydroxyurea can prevent stroke recurrence in children with SCA; after transfusions are ...
https://clinicaltrials.gov/ct2/show/NCT00122980
ATR-dependent pathways control hEXO1 stability in response to stalled forks - Zurich Open Repository and ArchiveATR-dependent pathways control hEXO1 stability in response to stalled forks - Zurich Open Repository and Archive
Nucleases play important roles in DNA synthesis, recombination and repair. We have previously shown that human exonuclease 1 (hEXO1) is phosphorylated in response to agents stalling DNA replication and that hEXO1 consequently undergoes ubiquitination and degradation in a proteasome-dependent manner. In the present study, we have addressed the identity of the pathway transducing stalled-replication signals to hEXO1. Using chemical inhibitors, RNA interference, ATM- and ATR-deficient cell lines we have concluded that hEXO1 phosphorylation is ATR-dependent. By means of mass spectrometry, we have identified the sites of phosphorylation in hEXO1 in undamaged cells and in cells treated with hydroxyurea (HU). hEXO1 is phosphorylated at nine basal sites and three additional sites are induced by HU treatment. Analysis of single- and multiple-point mutants revealed that mutation to Ala of the three HU-induced sites of phosphorylation partially rescued HU-dependent degradation of hEXO1 and additionally ...
http://www.zora.uzh.ch/id/eprint/3844/
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Concomitant 5-FU, hydroxyurea and cisplatin with external beam radiation therapy for locally advanced pancreatic cancerConcomitant 5-FU, hydroxyurea and cisplatin with external beam radiation therapy for locally advanced pancreatic cancer
The aim of the study was to determine the efficacy and toxicity of alternate week concurrent 5-fluorouracil, hydroxyurea, and cisplatin with radiotherapy for locally advanced pancreatic adenocarcinoma. Patients received 5-fluorouracil, hydroxyurea and cisplatin with radiotherapy on an alternate week basis. Chemoradiotherapy was given day 1-5, and no therapy given day 6-14 for each 14 day cycle. Chemotherapy doses were as follows: hydroxyurea 1 mg every 12 h starting day 0, 5-fluorouracil 800 mg/m(2)/day for 5 days starting day 1, and cisplatin 20 mg/m(2) daily for 5 days every other cycle. A radiation dose of 6000 cGy was prescribed. Acute toxicities were monitored and therapy modified for hematologic toxicity. Nine patients enrolled, however eight were evaluable; one patient expired prior to therapy. The median radiation dose delivered was 5540 cGy. Sixty-three percent required a chemotherapy dose reduction. Fifty percent achieved local control by radiographic imaging after completion of ...
https://www.spandidos-publications.com/or/4/5/877
BLM Deficiency Is Not Associated with Sensitivity to Hydroxyurea-Induced Replication StressBLM Deficiency Is Not Associated with Sensitivity to Hydroxyurea-Induced Replication Stress
Journal of Nucleic Acids is a peer-reviewed, Open Access journal that publishes original research articles as well as review articles covering all structural, chemical, and functional aspects of DNA and RNA research.
https://www.hindawi.com/journals/jna/2010/319754/
Modulation of erythroid adhesion receptor expression by hydroxyurea in children with sickle cell disease | HaematologicaModulation of erythroid adhesion receptor expression by hydroxyurea in children with sickle cell disease | Haematologica
Figure 2. Lu/BCAM expression on red blood cells (RBC) and on reticulocytes. For each group under study (Control, hydroxy-urea-treated [HU], VOC and NonVOC), the number of Lu/BCAM molecules/Lu-positive (Lu-pos) RBC or reticulocyte (A,E), and the percentage of Lu/BCAM-positive (Lu-pos) RBC or reticulocytes (C,G) are indicated. Lu/BCAM expression is also shown along a longitudinal follow-up of seven patients (B,D,F,H) initially included in the VOC-group and secondarily re-included in hydroxyurea-group after hydroxyurea therapy. Values are given as median, lower quartile, upper quartile, minimum and maximum for each group of patients and controls ...
http://www.haematologica.org/content/93/4/502.figures-only
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New data intensifies interest in hydroxyurea.: Newly publicized trial data are showing that hydroxyurea has strong anti-HIV activity, especially when combined w
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Testicular Toxicity Characters And Mechanisms Of Hydroxyurea On Rats | 69248Testicular Toxicity Characters And Mechanisms Of Hydroxyurea On Rats | 69248
Objective: Apoptosis plays a dominant role in both spontaneous spermatogenesis and germ cell death. This study was aimed to investigate the functions of relate...
https://www.omicsonline.org/proceedings/testicular-toxicity-characters-and-mechanisms-of-hydroxyurea-on-rats-69248.html
Hydroxyurea - Side Effects, Precautions, and ContraindicationsHydroxyurea - Side Effects, Precautions, and Contraindications
Hydroxyurea can cause side effects such as low white blood cell count. Seek immediate medical attention if you experience any allergic reactions such as a rash.
https://www.skh.com.sg/patient-care/medicine/hydroxyurea/side-effects
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It has been shown previously that loss of Chk1 expression results in the inability of cells to arrest at G2-M after DNA damage and leads to apoptosis (3). To further elucidate the role of the Chk1 pathway in the checkpoint response, in particular after stalled DNA replication, we down-regulated levels of Chk1 in U2OS cells using siRNA specific for the Chk1 gene followed by HU treatment. As a control, U2OS cells were transfected with scrambled siRNA. Cells were treated with HU for 18 h and washed with PBS to allow recovery from stalled DNA replication and reentry into the cell cycle. Cell cycle profiles were determined by fluorescence-activated cell sorting analysis every 24 h (Fig. 1A ). After treatment with HU, both control and Chk1-siRNA cells showed significant accumulation in the late G1 phase (52% and 47%, respectively; Fig. 1B). After HU was removed, control U2OS cells entered into the S and G2-M phases in 24 h and showed cell cycle profiles similar to those of untreated control U2OS cells ...
https://mct.aacrjournals.org/content/7/8/2509
Repositorio da Producao Cientifica e Intelectual da Unicamp: In Vitro And In Vivo Anti-angiogenic Effects Of HydroxyureaRepositorio da Producao Cientifica e Intelectual da Unicamp: In Vitro And In Vivo Anti-angiogenic Effects Of Hydroxyurea
Hydroxyurea (HU), or hydroxycarbamide, is used for the treatment of some myeloproliferative and neoplastic diseases, and is currently the only drug approved by the FDA for use in sickle cell disease (SCD). Despite the relative success of HU therapy for SCD, a genetic disorder of the hemoglobin β chain that results in red-cell sickling, hemolysis, vascular inflammation and recurrent vasoocclusion, the exact mechanisms by which HU actuates remain unclear. We hypothesized that HU may modulate endothelial angiogenic processes, with important consequences for vascular inflammation. The effects of HU (50-200. μM; 17-24. h) on endothelial cell functions associated with key steps of angiogenesis were evaluated using human umbilical vein endothelial cell (HUVEC) cultures. Expression profiles of the HIF1A gene and the miRNAs 221 and 222, involved in endothelial function, were also determined in HUVECs following HU administration and the direct in vivo antiangiogenic effects of HU were assessed using a ...
http://repositorio.unicamp.br/jspui/handle/REPOSIP/87263
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Hydrea - PharmasaveHydrea - Pharmasave
Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.. Anemia: Hydroxyurea may cause low levels of red blood cells. If you experience symptoms of reduced red blood cell count (anemia) such as shortness of breath, feeling unusually tired, or pale skin, contact your doctor as soon as possible.. Your doctor will do blood tests regularly to monitor the number of specific types of blood cells, including red blood cells, in your blood. Birth Control: There is the possibility of birth defects if either the father or mother is using hydroxyurea at the time of conception. Men should use effective birth control while taking hydroxyurea and for at least 1 year after completing treatment.. Blood clotting: This medication can reduce the number of platelet ...
http://www.pharmasave.com/medications/hydrea/
Browsing Student Research Forum Archives by Subject HydroxyureaBrowsing Student Research Forum Archives by Subject Hydroxyurea
Currently, hydroxyurea (HU), a potent inducer of fetal hemoglobin (Hb F), is the only approved drug for the management of sickle cell disease (SCD).Although the mechanism of induction of Hb F by HU is still unknown, but ...
http://archie.kumc.edu/handle/2271/63/browse?value=Hydroxyurea&type=subject
Hydroxyurea: Side Effects, Dosage, Uses, and MoreHydroxyurea: Side Effects, Dosage, Uses, and More
Hydroxyurea oral capsule (Hydrea, Droxia) is used to treat certain cancers and sickle cell disease. Learn about side effects, warnings, dosage, and more.
https://www.healthline.com/health/hydroxyurea-oral-capsule
Hydroxyurea | Roswell Park Cancer InstituteHydroxyurea | Roswell Park Cancer Institute
Brand Names Hydria®, Droxia (There may be other brand names for this medication) How is it Administered? Hydroxyurea is taken by mouth (as a capsule). What is it Used For? This drug is given to treat several kinds of cancer including melanoma, squamous cell carcinoma of head or neck, chronic myelocytic leukemia (CML), and recurrent, metastatic, or inoperable ovarian cancer. How Does it Work?
https://www.roswellpark.org/patients/treatment/chemo-drug-therapy/hydroxyurea
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Hydroxyurea in Dogs | Dog Care - The Daily PuppyHydroxyurea in Dogs | Dog Care - The Daily Puppy
Hydroxyurea is registered for human use, sold under the brand names of Mylocel and Hydrea. Though the Food and Drug Administration does not recognize its use for animals, veterinarians prescribe ...
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Compound Report CardCompound Report Card
[ChEMBL Compound Description] ID:, InChI_Key:, Tradenames:Hydroxyurea | DROXIA | HYDREA, Synonyms:HYDROXYUREA | HYDROXYCARBAMIDE | DROXIA | HYDREA | SQ 1089 | SQ-1089
https://www.ebi.ac.uk/chembldb/index.php/compound/inspect/CHEMBL467
Previous studies have indicated that hSSB
Discussion Enzymatically active DNA-PK is a central component of the cellular response to replication fork inhibition [6]. For instance, cells depleted of endogenous DNA-PKcs or expressing an enzymatically deficient kinase mutant are unable to efficiently restart stalled replication forks and show reduced clonogenic survival when treated with hydroxyurea [7]. With the notable exception of RPA32 [8], as well as of auto-phosphorylation [7], few relevant DNA-PK substrates have however been identified in response to replication stress. In this article we demonstrate that hSSB1 S134 phosphorylation is required for clonogenic survival of cells treated with the replication stress compounds hydroxyurea, aphidicolin and camptothecin, as well as establish that phosphorylation is primarily a result of DNA-PK activity. As a small decrease in hSSB1 S134 phosphorylation was also observed following the inhibition of ATM and ATR, we cannot however exclude that these kinases may also contribute a small amount to ...
http://pentynoic-acid-stp-ester.com/index.php?g=Wap&m=Article&a=detail&id=3959
Suchergebnis: Margolin, Kim A.Suchergebnis: Margolin, Kim A.
Abstract A group of 18 patients with advanced cancer were entered on a phase I study of a 120-h continuous intravenous infusion of hydroxyurea. The dose of hydroxyurea was escalated in cohorts of patients from 1 to 2 to 3.2 g/m2 per day. The primary dose-limiting toxicity was neutropenia,... mehr ...
http://finden.nationallizenzen.de/Search/Results?lookfor=Margolin%2C%20Kim%20A.&type=Author&d%5B%[email protected]
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While you are being treated with hydroxyurea, and after you stop using it, do not have any immunizations (vaccines) without your doctors approval. Hydroxyurea may lower your bodys resistance and there is a chance you might get the infection the vaccine is meant to prevent. In addition, other persons living in your household should not get live vaccines (eg, nasal flu vaccine, measles, mumps, or rubella) since there is a chance they could pass the infection on to you. Also, avoid persons who have had a live vaccine. Do not get close to them and do not stay in the same room with them for very long. If you cannot take these precautions, you should consider wearing a protective face mask that covers the nose and mouth ...
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The Chemistry Development Kit / Mailing ListsThe Chemistry Development Kit / Mailing Lists
Hi All! I got 2-3 messages on ModelBuilder 3D and I do think it would be good to designate the package as deprecated as it fails in many cases. I would also like to share a bug : in many drug-size molecules the builder assigns bad MMFF94 atom types to the amide Ns, which results in bad 3D geometry, namely neglecting the amide plane. It works well in cases when the amide in like NC=OR, where R is alkyl group, but fails when the first R atom is not C. Therefore in cases like urea, hydroxyurea the result is bad. The problem was in MMFF94BasedAtomTypePattern where you have to change the N atom HOSECODE pattern N-[1-3];[CH]{1,3}.{1}+[A-Z]{0,3}+[,]?+=OC.*+ to N-[1-3];[CH]{1,3}.{1}+[A-Z]{0,3}+[,]?+=O[CNX].*+ to handle other types of amides. How can I report this bug ? Thanks, Daniel ...
https://sourceforge.net/p/cdk/mailman/cdk-devel/?viewmonth=201204&viewday=5
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Therapy-Related Acute Myelogenous Leukemia in a Hydroxyurea-Treated Patient With Sickle Cell Anemia | Annals of Internal...Therapy-Related Acute Myelogenous Leukemia in a Hydroxyurea-Treated Patient With Sickle Cell Anemia | Annals of Internal...
Background: Hydroxyurea is an antimetabolite that minimizes pain and prolongs survival in patients with sickle cell anemia (1). It is not widely prescribed because of concerns about late effects, including cancer (2), and its leukemogenic risk is extrapolated from its reported risk in myeloproliferative disorders (3). Few cases of leukemia in patients with sickle cell anemia have been described, and only half of them report cytogenetics (4). Acute myelogenous leukemia (AML) in patients with sickle cell anemia receiving hydroxyurea treatment is exceptionally rare, but data on its true incidence are insufficient (1, 2). Whether AML in hydroxyurea-treated patients with sickle cell anemia is coincidental or related to therapy remains an unanswered question (2) ...
http://annals.org/aim/article-abstract/1033176/therapy-related-acute-myelogenous-leukemia-hydroxyurea-treated-patient-sickle-cell
Synergistic antiviral action of ribonucleotide reductase inhibitors and 3′-azido-3′-deoxythymidine on HIV type 1 infection in...
TY - JOUR. T1 - Synergistic antiviral action of ribonucleotide reductase inhibitors and 3′-azido-3′-deoxythymidine on HIV type 1 infection in vitro. AU - Giacca, Mauro. AU - Borella, Stefania. AU - Calderazzo, Francesca. AU - Bianchi, Luigi Chieco. AU - DAgaro, Pierlanfranco. AU - Rampazzo, Chiara. AU - Bianchi, Vera. AU - Reichard, Peter. PY - 1996/5/20. Y1 - 1996/5/20. N2 - Ribonucleotide reductase inhibitors reduce the cellular supply of DNA precursors (dNTP) by interfering with their de novo synthesis. A secondary effect is the stimulation of the uptake and phosphorylation of extracellular deoxynucleosides, including their analogs, e.g., 3′-azidothymidine (AZT). Both effects are relevant to HIV replication, which requires dNTP and is impaired by the triphosphate of AZT. Earlier we demonstrated that ribonucleotide reductase inhibitors - hydroxyurea, and two deoxycytidine analogs specifically active in lymphoid cells - increased the phosphorylation of AZT in CEM cells by prolonging the ...
https://moh-it.pure.elsevier.com/en/publications/synergistic-antiviral-action-of-ribonucleotide-reductase-inhibito
Effects of hydroxyurea treatment for patients with hemoglobin SC disease<...
TY - JOUR. T1 - Effects of hydroxyurea treatment for patients with hemoglobin SC disease. AU - Luchtman-Jones, Lori. AU - Pressel, Sara. AU - Hilliard, Lee. AU - Brown, R. Clark. AU - Smith, Mary G.. AU - Thompson, Alexis A.. AU - Lee, Margaret T.. AU - Rothman, Jennifer. AU - Rogers, Zora R.. AU - Owen, William. AU - Imran, Hamayun. AU - Thornburg, Courtney. AU - Kwiatkowski, Janet L.. AU - Aygun, Banu. AU - Nelson, Stephen. AU - Roberts, Carla. AU - Gauger, Cynthia. AU - Piccone, Connie. AU - Kalfa, Theodosia. AU - Alvarez, Ofelia. AU - Hassell, Kathryn. AU - Davis, Barry R.. AU - Ware, Russell E.. N1 - Publisher Copyright: © 2016 Wiley Periodicals, Inc. Copyright: Copyright 2016 Elsevier B.V., All rights reserved.. PY - 2016/2/1. Y1 - 2016/2/1. N2 - Although hemoglobin SC (HbSC) disease is usually considered less severe than sickle cell anemia (SCA), which includes HbSS and HbS/β0-thalassemia genotypes, many patients with HbSC experience severe disease complications, including ...
https://utsouthwestern.pure.elsevier.com/en/publications/effects-of-hydroxyurea-treatment-for-patients-with-hemoglobin-sc-
Effect of hydroxyurea on the frequency of painful crises in sickle cell anemia. Investigators of the Multicenter Study of...Effect of hydroxyurea on the frequency of painful crises in sickle cell anemia. Investigators of the Multicenter Study of...
Hydroxyurea therapy can ameliorate the clinical course of sickle cell anemia in some adults with three or more painful crises per year. Maximal tolerated doses of hydroxyurea may not be necessary to achieve a therapeutic effect. The beneficial effects of hydroxyurea do not become manifest for severa …
https://pubmed.ncbi.nlm.nih.gov/7715639/?dopt=Abstract
Hydroxyurea treatment does not increase blood viscosity and improves red blood cell rheology in sickle cell anemia |...Hydroxyurea treatment does not increase blood viscosity and improves red blood cell rheology in sickle cell anemia |...
50% of patients had 1 α-gene deleted (−α3.7 deletion). In agreement with previous studies,1,9 they exhibited lower mean cell volume, higher hematocrit and hemoglobin, increased RBC deformability, decreased RBC aggregates strength (P,0.05 for all parameters) and similar blood viscosity compared to patients without α-thalassemia (data not shown). The magnitude of the hematological/hemorheological responses under HU treatment was similar in the two groups, except for hemoglobin (+16 vs. +8%, P,0.05), hematocrit (+23 vs. +11%, P,0.05), the hematocrit/blood viscosity ratio (+34 vs. +8%, P,0.05) and RBC deformability (at 30 Pa: +65 vs. +26%, P,0.05), which increased more in patients without α-thalassemia than in patients with it. The effect of HU on the decrease of the number of VOC/STA events was similar in the two subgroups.. In agreement with previous studies, HU significantly decreased the rates of hospitalization for VOC and ACS in SCA patients who frequently exhibited these ...
http://www.haematologica.org/content/100/10/e383
Effect of cisplatin, topotecan, daunorubicin and hydroxyurea on human mesenchymal stem cells].<...Effect of cisplatin, topotecan, daunorubicin and hydroxyurea on human mesenchymal stem cells].<...
TY - JOUR. T1 - [Effect of cisplatin, topotecan, daunorubicin and hydroxyurea on human mesenchymal stem cells].. AU - Li, Jing. AU - Law, Ka Wai Helen. AU - Liu, Yu Lung. AU - Chan, Godfrey Chi Fung. PY - 2010/8/1. Y1 - 2010/8/1. N2 - Mesenchymal stem cells (MSC) are important cellular component of the bone marrow microenvironment in supporting hemopoiesis. Li J et al reported previously that MSCs are resistant to chemotherapy commonly used in hematologic malignancies but are relatively sensitive to anti-microtubule agents. However, the response of MSCs to other chemotherapeutic agents commonly used in solid tumour settings remains unknown. This study was purposed to evaluate the acute direct effects of 4 individual chemotherapeutic agents on human MSCs (hMSC), including cisplatin, topotecan, daunorubicin and hydroxyurea. Using an in vitro culture system, the chemosensitivity of hMSC was determined by XTT assay and compared with NB-4 cells and normal peripheral blood mononuclear cells (PBMNC). ...
https://research.polyu.edu.hk/en/publications/effect-of-cisplatin-topotecan-daunorubicin-and-hydroxyurea-on-hum
The Impact of Phlebotomy and Hydroxyurea on Survival and Risk of Thrombosis among Older Patients with Polycythemia Vera
Nikolai Podoltsev, M.D., Ph.D. presents from ASH 2017 on the impact of phlebotomy and hydroxyurea on survival and risk of thrombosis among older patients with PV., MedEd On The Go is the new mobile-friendly platform that delivers comprehensive education in short video episodes. Its the first online education platform designed to fit your busy schedule.
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The Impact of Phlebotomy and Hydroxyurea on Survival and Risk of Thrombosis among Older Patients with Polycythemia Vera
Nikolai Podoltsev, M.D., Ph.D. presents from ASH 2017 on the impact of phlebotomy and hydroxyurea on survival and risk of thrombosis among older patients with PV., MPNUniversity.tv Website
http://www.mpnuniversity.tv/MPNTVNetwork/TabId/876/VideoId/1991/The-Impact-Of-Phlebotomy-And-Hydroxyurea-On-Survival-And-Risk-Of-Thrombosis-Among-Older-Patients-With-Polycythemia-Vera.aspx
Background Sickle cell anaemia (SCA) is associated with significant morbidity from | BX-795 inhibits HSV-1 and HSV-2 replicationBackground Sickle cell anaemia (SCA) is associated with significant morbidity from | BX-795 inhibits HSV-1 and HSV-2 replication
Background Sickle cell anaemia (SCA) is associated with significant morbidity from acute complications and organ dysfunction beginning in the first 12 months of existence. function. Hydroxyurea significantly decreased pain and dactylitis with styles for decreased acute chest syndrome, hospitalisation and transfusion. Hydroxyurea improved PKI-587 biological activity haemoglobin and HbF and decreased WBC count. Toxicity was limited to mild-moderate neutropaenia. Interpretation Although hydroxyurea treatment did not reduce splenic and renal dysfunction assessed by Rabbit Polyclonal to GLB1 main endpoint steps, it resulted in major PKI-587 biological activity clinical benefit because of diminished acute complications, beneficial haematologic results, and a lack of unexpected toxicities. Based on the security and effectiveness data from this trial, hydroxyurea can now become regarded as for those very young children with SCA. Intro Sickle cell anaemia (SCA) is definitely characterized by haemoglobin ...
http://bx-795.com/background-sickle-cell-anaemia-sca-is-associated-with-significant-morbidity-from/
DNA replication inhibitorsDNA replication inhibitors
Project Title: Development of high throughput assay for screening of novel DNA replication inhibitors for therapeutic purposes Supervisors: Professor Christian Speck, Professor David Rueda Funding: Tuition fees plus £21,000 pa stipend for 3.5 years Date posted: 09 July 2021 Closing date: 04 August 2021 The student will develop a fluorescence-based assay to identify novel DNA replication inhibitors for anti-cancer therapy. Inhibitors will be consequently characterised for their impact on the multi-step DNA replication process and on cancer cell growth. This interdisciplinary project will train the student in biochemistry, biophysics and drug screening. Project details , LMS 3.5-year Studentships , Apply ...
https://www.specklab.com/tag/dna-replication-inhibitors/
New treatment for babies with sickle cell anemia ( Oral liquid hydroxyurea had shown good ...)New treatment for babies with sickle cell anemia ( Oral liquid hydroxyurea had shown good ...)
Health,Oral liquid hydroxyurea had shown good results when administered to ba...Sickle cell anemia is one of the sickle cell disease. A sickle cel...Researchers of St. Jude Childrens Research Hospital US have fou...Researchers have said that short-term liquid hydroxyurea therapy c...Reference: Blood June 2005...,New,treatment,for,babies,with,sickle,cell,anemia,medicine,medical news today,latest medical news,medical newsletters,current medical news,latest medicine news
http://www.bio-medicine.org/medicine-news/New-treatment-for-babies-with-sickle-cell-anemia-3719-1/
JCI - A role for nitric oxide in hydroxyurea-mediated fetal hemoglobin inductionJCI - A role for nitric oxide in hydroxyurea-mediated fetal hemoglobin induction
Figure 1 summarizes the current understanding of hydroxyurea-mediated induction of fetal hemoglobin synthesis. Based on the work of Cokic et al. (2) a link between hydroxyurea, NO, sGC, and fetal hemoglobin now exists (Figure 1). Figure 1 also shows where our understanding of this process remains incomplete, particularly: 1) how is hydroxyurea converted to NO in vivo, 2) can hydroxyurea directly activate sGC, and 3) how does an increase in cGMP induce fetal hemoglobin production? Chemically, the conversion of hydroxyurea to NO requires a three-electron oxidation. While a number of heme- and copper-containing proteins react with hydroxyurea to produce NO in vitro through the intermediacy of both radical and nitroso intermediates (3-6), surprisingly little information exists regarding the in vivo oxidative metabolism of hydroxyurea (12). Some work suggests that NO release from hydroxyurea likely occurs during liver metabolism (13), but to date the actual site and oxidant of in vivo hydroxyurea ...
https://www.jci.org/articles/view/17597
SciELO - Brazil - Mutagenicity of hydroxyurea in lymphocytes from patients with sickle cell disease Mutagenicity of...SciELO - Brazil - Mutagenicity of hydroxyurea in lymphocytes from patients with sickle cell disease Mutagenicity of...
MUTAGENESIS RESEARCH ARTICLE. Mutagenicity of hydroxyurea in lymphocytes from patients with sickle cell disease. André Salim KhayatI; Adriana Costa GuimarãesI; Plínio Cerqueira CardosoI; Patrícia Danielle Lima de LimaI; Marcelo de Oliveira BahiaII; Lusânia M. Greggi AntunesIII; Rommel Rodríguez BurbanoI IUniversidade Federal do Pará, Centro de Ciências Biológicas, Departamento de Biologia, Belém, PA, Brazil IIUniversidade Federal do Pará, Centro de Ciências Biológicas, Departamento de Patologia, Belém, PA, Brazil IIIFaculdade de Medicina do Triângulo Mineiro, Deptartamento de Ciências Biológicas, Uberaba, MG, Brazil. Correspondence ABSTRACT Hydroxyurea is commonly used in the treatment of myeloproliferative diseases and in patients with sickle cell disease (SCD). The use of this antineoplastic agent in patients with SCD is justified because of the drugs ability to increase fetal hemoglobin levels, thereby decreasing the severity of SCD. However, high doses or prolonged ...
https://www.scielo.br/j/gmb/a/tNdqYnVBs3T7NzQwJNRwwwF/?lang=en
Hydroxyurea Treatment for Sickle Cell Anemia in Africa | American Academy of PediatricsHydroxyurea Treatment for Sickle Cell Anemia in Africa | American Academy of Pediatrics
Thank you for your interest in spreading the word on American Academy of Pediatrics.. NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.. ...
https://aapgrandrounds.aappublications.org/content/41/5/53/tab-e-letters
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Sickle cell: Govt agrees to provide Hydroxyurea under NHIS | Health NewsSickle cell: Govt agrees to provide Hydroxyurea under NHIS | Health News
The government has agreed that hydroxyurea, a modifying therapy for sickle cell patients, will now be provided under the National Health Insurance Scheme (NHIS). Vice-President Mahamudu Bawumia disclosed in a Facebook post as Ghana joined the rest of the world to mark Sickle Cell Awareness Day on 19 June 2021. The decision to provide hydroxyurea under the NHIS was taken in consultation...
https://www.classfmonline.com/news/health/Sickle-cell-Gov-t-agrees-to-provide-Hydroxyurea-under-NHIS-25260
Intensive treatment and stem cell transplantation in chronic myelogenous leukemia: Long-term follow-up - Lund UniversityIntensive treatment and stem cell transplantation in chronic myelogenous leukemia: Long-term follow-up - Lund University
abstract = In the present study we combined interferon (IFN) and hydroxyurea (HU) treatment, intensive chemotherapy and autologous stem cell transplantation (SCT) in newly diagnosed chronic myelogenous leukemia patients aged below 56 years, not eligible for allogeneic SCT. Patients who had an HLA-identical sibling donor and no contraindication went for an allogeneic SCT (related donor, RD). After diagnosis, patients not allotransplanted received HU and IFN to keep WBC and platelet counts low. After 6 months patients with Ph-positive cells still present in the bone marrow received 1-3 courses of intensive chemotherapy. Those who became Ph-negative after IFN+HU or after 1-3 chemotherapy courses underwent autologous SCT. Some patients with poor cytogenetic response were allotransplanted with an unrelated donor (URD). IFN+HU reduced the percentage of Ph-positive metaphases in 56{\%} of patients, and 1 patient became Ph-negative. After one or two intensive cytotherapies 86 and 88{\%} had a Ph ...
https://portal.research.lu.se/portal/en/publications/intensive-treatment-and-stem-cell-transplantation-in-chronic-myelogenous-leukemia-longterm-followup
Intensive treatment and stem cell transplantation in chronic myelogenous leukemia: Long-term follow-upIntensive treatment and stem cell transplantation in chronic myelogenous leukemia: Long-term follow-up
article{801ae827-4c64-4154-8fc7-42929426f3d8, abstract = {In the present study we combined interferon (IFN) and hydroxyurea (HU) treatment, intensive chemotherapy and autologous stem cell transplantation (SCT) in newly diagnosed chronic myelogenous leukemia patients aged below 56 years, not eligible for allogeneic SCT. Patients who had an HLA-identical sibling donor and no contraindication went for an allogeneic SCT (related donor, RD). After diagnosis, patients not allotransplanted received HU and IFN to keep WBC and platelet counts low. After 6 months patients with Ph-positive cells still present in the bone marrow received 1-3 courses of intensive chemotherapy. Those who became Ph-negative after IFN+HU or after 1-3 chemotherapy courses underwent autologous SCT. Some patients with poor cytogenetic response were allotransplanted with an unrelated donor (URD). IFN+HU reduced the percentage of Ph-positive metaphases in 56% of patients, and 1 patient became Ph-negative. After one or two intensive ...
https://lup.lub.lu.se/search/publication/801ae827-4c64-4154-8fc7-42929426f3d8
Repositorio da Producao Cientifica e Intelectual da Unicamp: Therapy With Hydroxyurea Is Associated With Reduced Adhesion...Repositorio da Producao Cientifica e Intelectual da Unicamp: Therapy With Hydroxyurea Is Associated With Reduced Adhesion...
Propagation of the vaso-occlusive process in sickle cell anaemia (SCA) is a complex process involving the adhesion of steady-state SCA patients red cells and reticulocytes to the vascular endothelium. The effect of hydroxyurea therapy (HUT) on the adhesive properties of sickle cells and the expression of adhesion molecule genes by erythroid cells of SCA individuals is not yet fully understood. The expressions of the CD36 gene and the VLA-4-integrin subunit genes, CD49d (alpha-subunit) and CD29 (beta-subunit), were compared in the reticulocytes of steady-state SCA patients and patients on HUT using real-time PCR. Basal adhesion of red cells from these subjects was also compared using static adhesion assays, as was surface protein expression, using flow cytometry. Basal sickle red cell adhesion to fibronectin was significantly greater than that of normal cells (P , 0.01); in contrast, HUT was associated with significantly lower levels (P , 0.01) of red cell adhesion that were similar to those of ...
http://repositorio.unicamp.br/jspui/handle/REPOSIP/197175
Novel use Of Hydroxyurea in an African Region with Malaria (NOHARM): a trial for children with sickle cell anemia | Blood |...Novel use Of Hydroxyurea in an African Region with Malaria (NOHARM): a trial for children with sickle cell anemia | Blood |...
Key Points. Compared with placebo, hydroxyurea did not increase the incidence or severity of malaria events in Ugandan children with SCA.Hydroxyurea provided s
https://ashpublications.org/blood/article/130/24/2585/36868/Novel-use-Of-Hydroxyurea-in-an-African-Region-with
Effect of hydroxyurea on mortality and morbidity in adult sickle cell anemia: risks and benefits up to 9 years of treatment. -...Effect of hydroxyurea on mortality and morbidity in adult sickle cell anemia: risks and benefits up to 9 years of treatment. -...
JAMA. 2003 Apr 2;289(13):1645-51. Clinical Trial; Multicenter Study; Randomized Controlled Trial; Research Support, U.S. Govt, P.H.S.
https://www.ncbi.nlm.nih.gov/pubmed/12672732?access_num=12672732&link_type=MED&dopt=Abstract
Pharmaceutical Hydroxyurea Capsules at Best Price in Ahmedabad - Exporter and SupplierPharmaceutical Hydroxyurea Capsules at Best Price in Ahmedabad - Exporter and Supplier
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Hydroxyurea and sickle cell anemia: effect on quality of life by Samir K. Ballas, Franca B. Barton et al.Hydroxyurea and sickle cell anemia: effect on quality of life by Samir K. Ballas, Franca B. Barton et al.
Abstract Background The Multicenter Study of Hydroxyurea (HU) in Sickle Cell Anemia (MSH) previously showed that daily oral HU reduces painful sickle cell (SS) crises by 50% in patients with moderate to severe disease. The morbidity associated with this disease is known to have serious negative impact on the overall quality of life(QOL) of affected individuals. Methods The data in this report were collected from the 299 patients enrolled in the MSH. Health quality of llife (HQOL) measures were assessed in the MSH as a secondary endpoint to determine if the clinical benefit of HU could translate into a measurable benefit perceptible to the patients. HQOL was assessed with the Profile of Mood States, the Health Status Short Form 36 (SF-36), including 4-week pain recall, and the Ladder of Life, self-administered twice 2-weeks apart pre-treatment and every 6 months during the two-year, randomized, double-blind, treatment phase. The effects of factors including randomized treatment, age, gender, pre
https://digitalcommons.wayne.edu/biomedcentral/183/
Help 100 Sickle Cell Anaemia Children in Uganda - GlobalGivingHelp 100 Sickle Cell Anaemia Children in Uganda - GlobalGiving
Sickle cell anemia is a hereditary incurable defect confined to red blood cells. The basic defect is in the structure of hemoglobin molecule of the red blood cells which acquire sickle like shape in oxygen deficient environment. Due to this effect there is destruction of the cells which could even lead to the death of patients. This disease is now prominent in Teso Sub-Region in Uganda. SCOEN is working for betterment of these patients using HYDROXYUREA TREATMENT recommended to children. ...
https://www.globalgiving.org/projects/help-100-sickle-cell-anaemia-children-in-uganda/
Hydroxyurea Cost-Effective for Childhood Sickle Cell Anemia - MPRHydroxyurea Cost-Effective for Childhood Sickle Cell Anemia - MPR
Treating children with sickle cell anemia with hydroxyurea is associated with lower total medical costs (higher outpatient costs but lower inpatient costs) as compared to placebo.
https://www.empr.com/home/news/hydroxyurea-cost-effective-for-childhood-sickle-cell-anemia/
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Hydroxyurea Sickle Cell Anaemia | Online Drugstore
Hydroxyurea sickle cell anaemia: thought there was not room for much discussion as to him the facts. hydrea body brush uk heart s action was tumultuous cardiac sedatives were to be
http://openmetaverse.org/hydroxyurea-sickle-cell-anaemia/
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Ribonucleotide reductase (RNR) catalyzes the rate limiting step in dNTP biosynthesis and is tightly regulated at the transcription and activity levels. One of the best characterized responses of yeast to DNA damage is up-regulation of RNR transcription and activity and consequently, elevation of the dNTP pools. Hydroxyurea is a universal inhibitor of RNR that causes S phase arrest. It is used in the clinic to treat certain types of cancers. Here we studied the response of the fungal plant pathogen Fusarium oxysporum to hydroxyurea in order to generate hypotheses that can be used in the future in development of a new class of pesticides. F. oxysporum causes severe damage to more than 100 agricultural crops and specifically threatens banana cultivation world-wide. Although the recovery of F. oxysporum from transient hydroxyurea exposure was similar to the one of Saccharomyces cerevisiae, colony formation was strongly inhibited in F. oxysporum in comparison with S. cerevisiae. As expected, genomic ...
http://umu.diva-portal.org/smash/record.jsf?pid=diva2%3A1375382
Drug treatment means better, less costly care for children with sickle cell diseaseDrug treatment means better, less costly care for children with sickle cell disease
The benefits of hydroxyurea treatment in people with sickle cell disease are well known-fewer painful episodes, fewer blood transfusions and fewer hospitalizations. Now new research from the Johns Hopkins Childrens Center ...
https://medicalxpress.com/news/2013-09-drug-treatment-costly-children-sickle.html
A phase II study of the modulation of 5-fluorouracil and folinic acid with high-dose infusional hydroxyurea in metastatic...
BACKGROUND: Hydroxyurea (HU), an inhibitor of ribonucleotide reductase, may potentiate the activity of 5-fluorouracil (5-FU) and folinic acid (FA) by reducing the deoxyribonucleotide pool available for DNA synthesis and repair. However as HU may inhibit the formation of 5-fluoro-2-deoxyuridine-5-monophosphate (FdUMP), one of the principal active metabolites of 5-FU, the scheduling of HU may be critical. In vitro experiments suggest that administration of HU following 5-FU, maintaining the concentration in the region of 1 mM for six or more hours, significantly enhances the efficacy of 5-FU. PATIENTS AND METHODS: 5-FU/FA was given as follows: days 1 and 2-FA 250 mg/m2 (max. 350 mg) over two hours followed by 5-FU 400 mg/m2 by intravenous bolus (i.v.b.) over 15 minutes and subsequently 5-FU 400 mg/m2 infusion (ivi) over 22 hours. HU was administered on day 3 immediately after the 5-FU with 3 g i.v.b. over 15 minutes followed by 12 g ivi over 12 hours. RESULTS: Thirty patients were entered into the study.
https://www.imm.ox.ac.uk/publications/536357
Barriers to hydroxyurea adherence and health-related quality of life in adolescents and young adults with sickle cell disease -...
Fingerprint Dive into the research topics of Barriers to hydroxyurea adherence and health-related quality of life in adolescents and young adults with sickle cell disease. Together they form a unique fingerprint. ...
https://www.scholars.northwestern.edu/en/publications/barriers-to-hydroxyurea-adherence-and-health-related-quality-of-l/fingerprints/?sortBy=alphabetically
The Powder Room - Visit MammothThe Powder Room - Visit Mammoth
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Target cell availability and the successful suppression of HIV by hydroxyurea and didanosine. | Harvard Catalyst Profiles |...Target cell availability and the successful suppression of HIV by hydroxyurea and didanosine. | Harvard Catalyst Profiles |...
Target cell availability and the successful suppression of HIV by hydroxyurea and didanosine. AIDS. 1998 Sep 10; 12(13):1567-70 ...
https://connects.catalyst.harvard.edu/Profiles/display/790918
How is Hydroxyurea used to treat severe psoriasis?How is Hydroxyurea used to treat severe psoriasis?
hydroxyurea (hydrea) has fewer side effects than some of the stronger systemic medications, but its also less effective. it can cause bone marrow problems and a higher chance of skin cancer.
https://www.webmd.com/skin-problems-and-treatments/psoriasis/qa/how-is-hydroxyurea-used-to-treat-severe-psoriasis
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Peptidyl 3-Substituted 1-Hydroxyureas as Isosteric Analogues of Succinylhydroxamate MMP Inhibitors | IRIS Univ. Bari
To evaluate N-hydroxyurea as zinc binding group in the design of MMP inhibitors, two peptidyl 1-hydroxyureas were prepared by N-hydroxycarbamoylation of the diastereomeric dipeptides H-Leu-Phe-NHMe and H-d-Leu-Phe-NHMe. Peptidyl 1-hydroxyureas were more potent than the parent peptides, but dramatically weaker (4-5 orders of magnitude) than the isosteric (R)-succinylhydroxamate analogue, which displays IC(50) in the range of nM vs MMP-1, -3, -7 and sub-nM vs MMP-2, -8, and -9. The peptidyl 1-hydroxyurea 1a attained an IC(50) of 20muM vs MMP-9, and substantially approaches inhibition of known N-hydroxyureas based on aminoacids or peptides against other zinc metalloenzymes and non-peptidic N-hydroxyureas against MMPs. Strong preference of the O-N1-CO unit for the antiperiplanar amide bond conformation seems to be the major limit for more effective zinc chelation. Methylation of a peptidyl 1-hydroxyurea at N3, to promote the synperiplanar O-N1-CO conformation required for zinc chelation and improve ...
https://ricerca.uniba.it/handle/11586/13988
Essential Thrombocythemia (ET) - Convincing data of ANAHYDRET study now published - Newsroom - Our Company - AOP OrphanEssential Thrombocythemia (ET) - Convincing data of ANAHYDRET study now published - Newsroom - Our Company - AOP Orphan
In 259 previously untreated, high-risk ET patients, diagnosed according to the WHO classification system, efficacy and tolerability of anagrelide compared to hydroxyurea was investigated in a prospective randomized non-inferiority phase III study in an a-priori ordered hypothesis. Confirmatory proof of non-inferiority of anagrelide was achieved after 6 months using the primary endpoint criteria and further confirmed after an observation time of 12 and 36 months for platelet counts, hemoglobin levels, leukocyte counts (significantly lower in hydroxyurea group due to its non-selective mode of action) (all p,0.001) and ET related events (Hazard Ratio [95%CI]=1.19[0.61-2.30], 1.03[0.57-1.81] and 0.92[0.57-1.46] respectively). During the total observation time of 730 patient-years, there was no significant difference between the anagrelide and hydroxyurea group regarding incidences of major arterial (7 vs. 8) and venous (2 vs.6) thrombosis, severe bleeding events (5 vs. 2), minor arterial (24 vs. 20) ...
https://www.aoporphan.com/at_en/our-company/newsroom/essential-thrombocythemia-et-convincing-data-of-anahydret-study-now-published
Martin Steinberg | School of Medicine
Published on 3/10/2017. Aleluia MM, Santiago RP, da Guarda CC, Fonseca TC, Neves FI, Quinto RS, Figueiredo CV, Yahouédéhou SC, Oliveira RM, Ferreira JR, Cerqueira BA, Barbosa CG, Milton JN, Steinberg MH, de Souza Gonçalves M. Genetic modulation of fetal hemoglobin in hydroxyurea-treated sickle cell anemia. Am J Hematol. 2017 May; 92(5):E70-E72. PMID: 28195442.. Read at: PubMed ...
https://www.bumc.bu.edu/busm/profile/martin-steinberg/
Examining the characteristics and beliefs of hydroxyurea users and nonusers among adults with sickle cell disease - Haywood -...Examining the characteristics and beliefs of hydroxyurea users and nonusers among adults with sickle cell disease - Haywood -...
Efforts to understand and overcome the barriers to the use of HU in treating SCD are an important area of inquiry. In this study, we sought to describe some of the characteristics, attitudes, and beliefs about HU among adult SCD patients. Nearly 83% of respondents who were categorized as former users of HU reported being on the drug for 1 year or less, with 56.5% being on it for less than 6 months. Many of these former users (39%) reported that they stopped because their doctor suggested it. We were unable to discern the reason why a patients doctor may have suggested that they stop taking HU. It is possible that the patient was told to temporarily stop taking HU after experiencing some of the well-known short-term toxicities of the drug, such as leukopenia. A patient may also be told to stop taking HU if that patient demonstrates an inability or unwillingness to comply with the treatment regimen. In their studies of provider barriers to the use of HU for SCD patients, both Zumberg et al. and ...
http://onlinelibrary.wiley.com/doi/10.1002/ajh.21883/full?globalMessage=0
1,2-dihydro-5-nitro-3H-1,2,4-triazol-3-one - Registration Dossier - ECHA1,2-dihydro-5-nitro-3H-1,2,4-triazol-3-one - Registration Dossier - ECHA
NTO is demonstrated to be ultimately biodegradable by different microbial species, belonging to various bacteria and fungi. The substance can totally transformed to urea and a polar compound assumed to be urea/ hydroxyurea. The first step of the microbial metabolisation is the nitroreduction of NTO within 24 hours to ATO. This is followed by a two week lasting period where the triazolone ring of ATO is cleaved to urea and probably hydroxyurea as second step. This reaction consists on the hydrolysis of the pseudo `guanido group of ATO. The metabolising strains are adapted to the substance and are collected from waste water contaminated with NTO. From this source source two strains could be isolated: - Penicillium chrysogenum CNCM. I-2081 and - Bacillus licheniformis CNCM. I-1915 Both strains were able to biodegrade the substance NTO to ATO and further to urea and hydroxyurea. Besides, a screening of microorganisms from various microbial collections including eight bacteria and 22 fungi, three ...
https://echa.europa.eu/it/registration-dossier/-/registered-dossier/5380/5/3/3
Common Sickle Cell Treatment Safe for Babies | National Institutes of Health (NIH)Common Sickle Cell Treatment Safe for Babies | National Institutes of Health (NIH)
The drug hydroxyurea, which is used to treat sickle cell disease in adults, also appears to be safe and effective for children as young as 8 months, a new study reports.
https://www.nih.gov/news-events/nih-research-matters/common-sickle-cell-treatment-safe-babies
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B78 Growth arrest represents an innate barrier to carcinogenesis. DNA damage and replicational stress are known to induce growth arrest and apoptotic death to avert genomic instability and consequently carcinogenesis. Working on the genotoxic stress induced by hydroxyurea and methylmethanesulfone, we observed a growth arrest at G1/S-phase that was mediated by destabilization of cyclin D1. The growth arrest was independent of the stability of cdc25A and preceded transcriptional up-regulation of p21waf1. Cyclin D1 destabilization involved its phosphorylation by GSK-3beta at threonine-286 since overexpression of the kinase-dead mutant of GSK-3beta or cyclin D1T286A mutant conferred stability to cyclin D1. Further, overexpression of cyclin D1T286A also helped in bypassing G1/S phase growth arrest. We also observed a rapid inactivation of Akt/PKB kinase in the presence of hydroxyurea. Enforced expression of the constitutively active Akt or viral oncoprotein HBx was sufficient to overcome growth ...
http://cancerpreventionresearch.aacrjournals.org/content/1/7_Supplement/B78
The risks and benefits of long-term use of hydroxyurea in sickle cell anemia: A 17.5 year follow-up. - PubMed - NCBIThe risks and benefits of long-term use of hydroxyurea in sickle cell anemia: A 17.5 year follow-up. - PubMed - NCBI
Am J Hematol. 2010 Jun;85(6):403-8. doi: 10.1002/ajh.21699. Multicenter Study; Randomized Controlled Trial; Research Support, N.I.H., Extramural
https://www.ncbi.nlm.nih.gov/pubmed/20513116?access_num=20513116&link_type=MED&dopt=Abstract
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How It works Hydrea is an antineoplastic. Thus, it works by the destroying the growth of the affected cells by stopping its reproduction process. This kills the affected cells and thereby ensures that they will not spread to the rest of the body.. Uses. The medication is mainly used to reduce the pain caused by sickle cell anemia. It is also useful in treating a number of cancers such as leukemia, breast cancer and ovarian cancer. When used with radiation therapy, this medication is effective in treating skin cancer too.. Dosage. The dosage of this medication is determined by the physician according to the severity of the condition and your response to the treatment. This medication is usually taken by mouth, with or without food. It is consumed once day on a daily basis. Do not crush or chew the capsule since this medication must be consumed wholly. Being exposed to this medication can increase the risk of side effects to a great extent. Thus, make sure that you do not break the capsule before ...
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contented82 | The Contented Family | Page 2
Firstly, you need to make sure youre getting enough hugs. Experts range from recommending between 8 - 12 hugs daily.. Secondly, you need to make sure that your hugs count. A half-hearted attempt will not have the same results. Give into the hug, throw both arms around your hug partner and fully embrace them, the longer the physical connection the better. I like to practice 3 breath hugs, no matter how busy you are, you can stop for this time. I also prefer to count breaths as oppose to seconds as that keeps me more in tune with my own bodys rhythm.. Finally, be the hug. Dont think about what you are cooking for dinner, your to do list or a meeting at work. The best way to get the most out of your hug is to focus on how it feels. Be mindful of the weight of the other person and how their body feels as it connects with yours.. Be the hug.. The Contented Family Hugging Challenge. For one week I am going to monitor my hugs. I am interested to see if I already hug enough, I have never counted so I ...
http://www.thecontentedfamily.co.uk/author/contented82/page/2/
Cid13 is a cytoplasmic poly(A) polymerase that regulates ribonucleotide reductase mRNA.Cid13 is a cytoplasmic poly(A) polymerase that regulates ribonucleotide reductase mRNA.
Fission yeast Cid13 and budding yeast Trf4/5 are members of a newly identified nucleotidyltransferase family conserved from yeast to man. Trf4/5 are thought to be essential DNA polymerases. We report that Cid13 is a poly(A) polymerase. Unlike conventional poly(A) polymerases, which act in the nucleus and indiscriminately polyadenylate all mRNA, Cid13 is a cytoplasmic enzyme that specifically targets suc22 mRNA that encodes a subunit of ribonucleotide reductase (RNR). cid13 mutants have reduced dNTP pools and are sensitive to hydroxyurea, an RNR inhibitor. We propose that Cid13 defines a cytoplasmic form of poly(A) polymerase important for DNA replication and genome maintenance.. ...
http://umu.diva-portal.org/smash/record.jsf?pid=diva2:354203
Induced cell cycle arrestInduced cell cycle arrest
Hydroxyurea (HU) is a small molecule drug that inhibits the enzyme ribonucleotide reductase (RNR), preventing the catalysis of ... Koç A, Wheeler LJ, Mathews CK, Merrill GF (January 2004). "Hydroxyurea arrests DNA replication by a mechanism that preserves ... Xu YJ, Singh A, Alter GM (November 2016). "Hydroxyurea Induces Cytokinesis Arrest in Cells Expressing a Mutated Sterol-14α- ... Platt OS (March 2008). "Hydroxyurea for the treatment of sickle cell anemia". The New England Journal of Medicine. 358 (13): ...
https://en.wikipedia.org/wiki/Induced_cell_cycle_arrest
Berlin PatientBerlin Patient
He was prescribed an unusual combination therapy: didanosine, indinavir and hydroxyurea. Hydroxyurea was the most unusual of ... Gibbs MA, Sorensen SJ (January 2000). "Hydroxyurea in the treatment of HIV-1". The Annals of Pharmacotherapy. 34 (1): 89-93. ...
https://en.wikipedia.org/wiki/Berlin_Patient
MeningiomaMeningioma
Newton HB (2007). "Hydroxyurea chemotherapy in the treatment of meningiomas". Neurosurgical Focus. 23 (4): E11. doi:10.3171/foc ... A 2007 study of whether hydroxyurea has the capacity to shrink unresectable or recurrent meningiomata is being further ...
https://en.wikipedia.org/wiki/Meningioma
Samuel CharacheSamuel Charache
In the early 1980s a team led by Charache began testing a few patients at Hopkins to see if hydroxyurea, a cancer drug, would ... They found that hydroxyurea treatment could increase recipients' blood levels of hemoglobin F, a form of hemoglobin primarily ... Subsequent investigation of the beneficial effects hydroxyurea in people with sickle cell disease has revealed multiple ... Agrawal, Rohit Kumar; Patel, Rakesh Kantilal; Shah, Varsha; Nainiwal, Lalit; Trivedi, Bhadra (June 2014). "Hydroxyurea in ...
https://en.wikipedia.org/wiki/Samuel_Charache
Polycythemia veraPolycythemia vera
These include hydroxyurea and interferon therapy, among others. The tendency of some practitioners to avoid chemotherapy if ... While hydroxyurea is considered a safer chemotherapy in this aspect, there is still some debate about its long-term safety. ...
https://en.wikipedia.org/wiki/Polycythemia_vera
Sickle cell retinopathySickle cell retinopathy
Hydroxyurea administration - Hydroxyurea is a drug that can be used as an alternative method of increasing fetal haemoglobin ... Hydroxyurea also provides the benefit of reducing inflammation. Haematopoetic stem cell transplantation - This process is more ...
https://en.wikipedia.org/wiki/Sickle_cell_retinopathy
Cryptococcus neoformansCryptococcus neoformans
Tripathi, K; Mor, V; Bairwa, NK; Del Poeta, M; Mohanty, BK (2012). "Hydroxyurea treatment inhibits proliferation of ...
https://en.wikipedia.org/wiki/Cryptococcus_neoformans
ThalassemiaThalassemia
Hydroxyurea is the only FDA approved drug for thalassemia. Patients who took 10 mg/kg of hydroxyurea every day for a year had ... Thalassemia patients who do not respond well to blood transfusions can take hydroxyurea or thalidomide, and sometimes a ... Keikhaei, Bijan (2015). "Clinical and Haematological Effects of Hydroxyurea in β -Thalassemia Intermedia Patients". Journal of ... The combination of thalidomide and hydroxyurea resulted in hemoglobin levels increasing significantly in transfusion-dependent ...
https://en.wikipedia.org/wiki/Thalassemia
AnagrelideAnagrelide
The hydroxyurea arm had a lower likelihood of myelofibrosis, arterial thrombosis, and bleeding, but it had a slightly higher ... July 2005). "Hydroxyurea compared with anagrelide in high-risk essential thrombocythemia". N. Engl. J. Med. 353 (1): 33-45. doi ... Anagrelide can be useful in times when hydroxyurea proves ineffective. Common side effects are headache, diarrhea, unusual ... Stopping anagrelide (and switching patients to hydroxyurea) appeared to reverse the degree of marrow fibrosis. Thus, patients ...
https://en.wikipedia.org/wiki/Anagrelide
ThrombocythemiaThrombocythemia
July 2005). "Hydroxyurea compared with anagrelide in high-risk essential thrombocythemia". The New England Journal of Medicine ... Extremely high platelet counts can be treated with hydroxyurea (a cytoreducing agent) or anagrelide (Agrylin). In Janus kinase ...
https://en.wikipedia.org/wiki/Thrombocythemia
Salicylhydroxamic acidSalicylhydroxamic acid
Inhibition of the enzyme by hydroxyurea, hydroxylamine, and acetohydroxamic acid". J Biol Chem. 240: 2407-2414. doi:10.1016/ ...
https://en.wikipedia.org/wiki/Salicylhydroxamic_acid
Acetohydroxamic acidAcetohydroxamic acid
Inhibition of the Enzyme by Hydroxyurea, Hydroxylamine, and Acetohydroxamic Acid". The Journal of Biological Chemistry. 240: ...
https://en.wikipedia.org/wiki/Acetohydroxamic_acid
Spinal muscular atrophySpinal muscular atrophy
Hydroxycarbamide (hydroxyurea) was shown effective in mouse models and subsequently commercially researched by Novo Nordisk, ... Grzeschik SM, Ganta M, Prior TW, Heavlin WD, Wang CH (August 2005). "Hydroxyurea enhances SMN2 gene expression in spinal ... placebo-controlled trial of hydroxyurea in spinal muscular atrophy". Neurology. 75 (24): 2190-7. doi:10.1212/WNL. ...
https://en.wikipedia.org/wiki/Spinal_muscular_atrophy
Potassium cyanatePotassium cyanate
For example, it is used to prepare the drug hydroxyurea. It is also used for the heat treatment of metals (e.g., Ferritic ...
https://en.wikipedia.org/wiki/Potassium_cyanate
Vanessa Northington GambleVanessa Northington Gamble
Brawley, Otis W. (2008-06-17). "National Institutes of Health Consensus Development Conference Statement: Hydroxyurea Treatment ... hydroxyurea treatment for sickle cell disease." "Introduction to special issue: advancing the ethics of community-based ... "NIH consensus development statement on hydroxyurea treatment for sickle cell disease". NIH Consensus and State-of-the-science ... "NIH consensus development statement on hydroxyurea treatment for sickle cell disease." "National Institutes of Health Consensus ...
https://en.wikipedia.org/wiki/Vanessa_Northington_Gamble
Drugs and Cosmetics Rules, 1945Drugs and Cosmetics Rules, 1945
Examples of substances under this schedule: Testolactone, Hydroxyurea, Carbutamide, Primidone etc. Schedule H: The drug label ...
https://en.wikipedia.org/wiki/Drugs_and_Cosmetics_Rules,_1945
Sickle cell diseaseSickle cell disease
Hydroxyurea had previously been used as a chemotherapy agent, and some concern exists that long-term use may be harmful, but ... Hydroxyurea and phlebotomy combined may be more effective than transfusion and chelation combined in terms of pain, life- ... Hydroxyurea, also known as hydroxycarbamide, probably reduces the frequency of painful episodes and the risk of life- ... Guidelines from NIH published in 2014 state that all children and adolescents should take hydroxyurea, as should adults with ...
https://en.wikipedia.org/wiki/Sickle_cell_disease
MegakaryocyteMegakaryocyte
The primary treatment consists of anagrelide or hydroxyurea to lower platelet levels. Congenital amegakaryocytic ...
https://en.wikipedia.org/wiki/Megakaryocyte
ClotrimazoleClotrimazole
Rodgers G. "Hydroxyurea and other disease-modifying therapies in sickle cell disease". UpToDate. Archived from the original on ...
https://en.wikipedia.org/wiki/Clotrimazole
FenleutonFenleuton
"1-{4-[3-(4-Fluorophenoxy)phenyl]-3-butyn-2-yl}-1-hydroxyurea". chemspider.com. Retrieved 24 December 2015. Marr KA, Lees P, ...
https://en.wikipedia.org/wiki/Fenleuton
Marc StrausMarc Straus
Cytokinetic analysis of L1210 leukemia after continuous infusion of hydroxyurea in vivo Straus, Marc J., Vivian Sege, and Sung ... "Synchronization of L1210 leukemia with hydroxyurea infusion and the effect of subsequent pulse dose chemotherapy." Cancer Treat ... "Cytokinetic analysis of L1210 leukemia after continuous infusion of hydroxyurea in vivo." Cancer research 39.5 (1979): 1616- ...
https://en.wikipedia.org/wiki/Marc_Straus
Cell synchronizationCell synchronization
Hydroxyurea is also used to treat certain types of cancer and blood disorders. Aphidocolin is a fungus-derived tetracyclic ... Hydroxyurea decreases the production of dNTPs by inhibiting the enzyme ribonucleotide reductase. This serves to halt DNA ... "Hydroxyurea Arrests DNA Replication by a Mechanism That Preserves Basal dNTP Pools". Journal of Biological Chemistry. 279 (1): ...
https://en.wikipedia.org/wiki/Cell_synchronization
Primary myelofibrosisPrimary myelofibrosis
Najean Y, Rain JD (November 1997). "Treatment of polycythemia vera: the use of hydroxyurea and pipobroman in 292 patients under ... Dexamethasone, alpha-interferon and hydroxyurea (also known as hydroxycarbamide) may play a role. Lenalidomide and thalidomide ... the development of myelofibrosis following these disorders may be accelerated by the oral chemotherapy drug hydroxyurea. The ...
https://en.wikipedia.org/wiki/Primary_myelofibrosis
Ribonucleotide reductaseRibonucleotide reductase
The drugs hydroxyurea and Motexafin gadolinium interfere with the action of this enzyme. Elledge SJ, Zhou Z, Allen JB (March ... "Mutations in the R2 subunit of ribonucleotide reductase that confer resistance to hydroxyurea". The Journal of Biological ...
https://en.wikipedia.org/wiki/Ribonucleotide_reductase
Sickle cell-beta thalassemiaSickle cell-beta thalassemia
Patients may receive hydroxyurea to induce the protective effects of increased fetal hemoglobin production. They may also ...
https://en.wikipedia.org/wiki/Sickle_cell-beta_thalassemia
Constance Tom NoguchiConstance Tom Noguchi
Noguchi has studied hydroxyurea and hemoglobin, showing that hydroxyurea can increase a form of fetal hemoglobin in sickle cell ... "Hydroxyurea induces fetal hemoglobin by the nitric oxide-dependent activation of soluble guanylyl cyclase". Journal of Clinical ...
https://en.wikipedia.org/wiki/Constance_Tom_Noguchi
Boston Childrens HospitalBoston Children's Hospital
... to try Hydroxyurea, a drug used to treat blood cancer, to treat her sickle cell disease. The treatment worked and Hydroxyurea ...
https://en.wikipedia.org/wiki/Boston_Children's_Hospital
Bcr-Abl tyrosine-kinase inhibitorBcr-Abl tyrosine-kinase inhibitor
Only cytotoxic drugs such as busulfan, hydroxyurea or interferon-alpha (rIFN-α) were utilized. Even though the first Bcr-Abl TK ...
https://en.wikipedia.org/wiki/Bcr-Abl_tyrosine-kinase_inhibitor
Transformation (genetics)Transformation (genetics)
Sakano K, Oikawa S, Hasegawa K, Kawanishi S (November 2001). "Hydroxyurea induces site-specific DNA damage via formation of ... and hydroxyurea (induces DNA base oxidation). UV light also induced competence in L. pneumophila. Charpentier et al. suggested ...
https://en.wikipedia.org/wiki/Transformation_(genetics)
Natural competenceNatural competence
Sakano, K; Oikawa, S; Hasegawa, K; Kawanishi, S (2001). "Hydroxyurea induces site-specific DNA damage via formation of hydrogen ... and hydroxyurea (causes oxidation of DNA bases). Charpentier et al. also showed that UV irradiation induces competence in L. ...
https://en.wikipedia.org/wiki/Natural_competence
Hydroxyurea: MedlinePlus Drug InformationHydroxyurea: MedlinePlus Drug Information
Hydroxyurea: learn about side effects, dosage, special precautions, and more on MedlinePlus ... When hydroxyurea is used to treat certain types of cancer, it may be taken once every third day. Take hydroxyurea at around the ... Before taking hydroxyurea,. *tell your doctor and pharmacist if you are allergic to hydroxyurea, any other medications, or any ... Hydroxyurea treats cancer by slowing or stopping the growth of cancer cells in your body. Hydroxyurea treats sickle cell anemia ...
https://medlineplus.gov/druginfo/meds/a682004.html
CDCs Sickle Cell Data Collection (SCDC) Data Brief: Hydroxyurea | CDCCDC's Sickle Cell Data Collection (SCDC) Data Brief: Hydroxyurea | CDC
Hydroxyurea Use Among Medicaid Beneficiaries with Sickle Cell Disease in California and Georgia, 2006-2016. Print-friendly ... During 2006-2016, the use of hydroxyurea (HU) among Medicaid beneficiaries with sickle cell disease (SCD) who lived in ... CDCs Sickle Cell Data Collection (SCDC) Data Brief: Hydroxyurea. ... FDA Prescribing Information for Hydroxyurea (pediatric patients): https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/ ...
https://www.cdc.gov/ncbddd/hemoglobinopathies/scdc-hydruxyurea-data-brief.html
Hydroxyurea ClinicHydroxyurea Clinic
The Hydroxyurea Clinic at Nationwide Childrens Hospital follows children with sickle cell disease who take hydroxyurea, the ... Hydroxyurea Clinic. The Hydroxyurea Clinic at Nationwide Childrens Hospital follows children with sickle cell disease who take ... Appointments at our Hydroxyurea Clinic require physician referral. To schedule a visit, please refer your physician to our ... Hydroxyurea Clinic. Nationwide Childrens Hospital. H11A. 700 Childrens Drive. Columbus, Ohio 43205. (614) 722-3250 ...
https://www.nationwidechildrens.org/specialties/sickle-cell-and-thalassemia-program/hydroxyurea-clinic
hydroxyurea Clinical Research Trials | CenterWatchhydroxyurea Clinical Research Trials | CenterWatch
Hydroxyurea Optimization Through Precision Study (HOPS) Hydroxyurea. Optimization through Precision Study (HOPS) is a ... hydroxyurea. therapy combined with tadalafil is superior to a combination of hydroxyurea. and ... hydroxyurea. for children with sickle cell anemia are 1) Develop and prospectively evaluate a population pharmacokinetic/ ... Anagrelide in Essential Thrombocythemia Patients With Hydroxyurea Resistance or Intolerance (SURPASS ET) This is a Phase 3 open ...
https://www.centerwatch.com/clinical-trials/listings/search/?q=hydroxyurea
PRIME PubMed | [A hydroxyurea-induced leg ulceration]PRIME PubMed | [A hydroxyurea-induced leg ulceration]
A hydroxyurea-induced leg ulceration]. Download Prime PubMed App to iPhone, iPad, or Android ... Diagnosis: hydroxyurea-induced leg ulceration and dermatomyositis-like skin changes.. *[Hydroxyurea induced-leg ulcer in ... Secondary cutaneous effects of hydroxyurea: possible pathogenetic mechanisms.. *Recurrence of hydroxyurea-induced leg ulcer ... Antineoplastic AgentsDrug EruptionsFemaleHumansHydroxyureaLeg UlcerMiddle AgedPolycythemia Vera ...
https://www.unboundmedicine.com/medline/citation/12092349/%5BA_hydroxyurea_induced_leg_ulceration%5D_
Chemical Database: Hydroxyurea (EnvironmentalChemistry.com)Chemical Database: Hydroxyurea (EnvironmentalChemistry.com)
This page contains information on the chemical Hydroxyurea including: 61 synonyms/identifiers. ... Hydroxyurea*Hydroxyurea (D4) *Hydroxyurea (USP) *Hydroxyurea [USAN:BAN]*Hydura*Hydurea*Idrossicarbamide [DCIT]*Litaler*Litalir* ... Hydroxyurea (EnvironmentalChemistry.com),/a,- This page contains information on the chemical Hydroxyurea including: 61 synonyms ... Hydroxyurea. Identifications. *CAS Number: 127-07-1*Synonyms/Related:*Bio1_000451*Bio1_000940*Bio1_001429*Biosupressin*C07044* ...
https://environmentalchemistry.com/yogi/chemicals/cn/Hydroxyurea.html
Hydroxyurea and risk of cutaneous vasculitic toxicitiesHydroxyurea and risk of cutaneous vasculitic toxicities
Unknown author (‎2006)‎. Hydroxyurea and risk of cutaneous vasculitic toxicities. WHO drug information 2006 ; 20(‎1)‎ : 17 ...
https://extranet.who.int/iris/restricted/handle/10665/73679
60429-0265 Hydroxyurea - CanMED: NDC60429-0265 Hydroxyurea - CanMED: NDC
CanMED: NDC. The Cancer Medications Enquiry Database (CanMED) is a two-part resource for cancer drug treatment related studies.
https://seer.cancer.gov/oncologytoolbox/canmed/ndconc/60429-0265/
Healing of an MRSA-colonized, hydroxyurea-induced leg ulcer withHealing of an MRSA-colonized, hydroxyurea-induced leg ulcer with
METHODS: We report the case of an immunosuppressed patient who developed a hydroxyurea-induced leg ulcer with subclinical MRSA ... infection which was subsequently treated with topical application of manuka honey, without cessation of hydroxyurea or ...
https://greenmedinfo.com/article/manuka-honey-appears-be-effective-antibacterial-wound-healing-agent-against-mr
Incidence of neuropathy in HIV-infected patients on monotherapy versus those on combination therapy with didanosine, stavudine...Incidence of neuropathy in HIV-infected patients on monotherapy versus those on combination therapy with didanosine, stavudine...
The combination of ddl + d4T also increases the risk of neuropathy but less than when hydroxyurea is included. ... hydroxyurea, 3.50 (95% CI: 1.81-6.77) for ddl + d4T, and 7.80 (95% CI: 3.92-15.5) for ddl + d4T + hydroxyurea. ... It is also not known if hydroxyurea, used to potentiate the antiviral efficacy of these drugs, may also increase the risk of ... The purpose of this analysis is to investigate if the combination of ddl and d4T, with or without hydroxyurea, has a higher ...
https://pubmed.ncbi.nlm.nih.gov/10716503/?dopt=Abstract
Interim Analysis Finds Benefits of Ruxolitinib to Treat PV in Patients Intolerant/Resistant to HydroxyureaInterim Analysis Finds Benefits of Ruxolitinib to Treat PV in Patients Intolerant/Resistant to Hydroxyurea
... who are resistant or intolerant to hydroxyurea. The full study findings with a 24-month follow-up are still to come. ... Patients with polycythemia vera (PV) who are resistant or intolerant to hydroxyurea (HU) may benefit from being treated with ... Ruxolitinib in PV patients resistant and/or intolerant to hydroxyurea: interim analysis of a European multi-centric ... Interim Analysis Finds Benefits of Ruxolitinib to Treat PV in Patients Intolerant/Resistant to Hydroxyurea. ...
https://www.ajmc.com/view/interim-analysis-finds-benefits-of-ruxolitinib-to-treat-pv-in-patients-intolerantresistant-to-hydroxyurea
Impact of hydroxyurea on clinical events in the BABY HUG trial.Impact of hydroxyurea on clinical events in the BABY HUG trial.
... Author(s): Thornburg CD, Files BA, Luo Z, Miller ST, Kalpatthi ... The Pediatric Hydroxyurea Phase 3 Clinical Trial (BABY HUG) was a phase 3 multicenter, randomized, double-blind, placebo- ... One hundred and ninety-three subjects were randomized to hydroxyurea (20 mg/kg/d) or placebo; there were 374 patient-years of ... Hydroxyurea was associated with statistically significantly lower rates of initial and recurrent episodes of pain, dactylitis, ...
http://www.druglib.com/abstract/th/thornburg-cd_blood_20120000.html
Hydroxyurea - Side Effects, Uses, Dosage, Overdose, Pregnancy, Alcohol | RxWikiHydroxyurea - Side Effects, Uses, Dosage, Overdose, Pregnancy, Alcohol | RxWiki
Get up-to-date information on Hydroxyurea side effects, uses, dosage, overdose, pregnancy, alcohol and more. Learn more about ... wear disposable gloves when handling hydroxyurea or bottles containing hydroxyurea. Anyone handling hydroxyurea should wash ... Hydroxyurea is a medication that must be handled with care. People who are not taking hydroxyurea should not be exposed to it. ... Hydroxyurea capsules are used to treat sickle cell anemia in adults. Hydroxyurea reduces the frequency of painful crises and ...
https://www.rxwiki.com/hydroxyurea
Drug repurposing: Hydroxyurea therapy improves the transfusion-free interval in HbE/beta-thalassemia-major patients with Xmn1...Drug repurposing: Hydroxyurea therapy improves the transfusion-free interval in HbE/beta-thalassemia-major patients with Xmn1...
Hydroxyurea (HU) is the most common drug used for the management of sickle-cell anemia but not thalassemia. Here, we aimed to ... Drug repurposing: Hydroxyurea therapy improves the transfusion-free interval in HbE/beta-thalassemia-major patients with Xmn1 ... Drug repurposing: Hydroxyurea therapy improves the transfusion-free interval in HbE/beta-thalassemia-major patients with Xmn1 ... Drug repurposing: Hydroxyurea therapy improves the transfusion-free interval in HbE/beta-thalassemia-major patients with Xmn1 ...
https://www.medrxiv.org/content/10.1101/2021.02.28.21251843v1
Dibenzoheterocyclic hydroxamic acids and hydroxy ureas as inhibitors of 5-lipoxygenase - Patent US-5036067-A - PubChemDibenzoheterocyclic hydroxamic acids and hydroxy ureas as inhibitors of 5-lipoxygenase - Patent US-5036067-A - PubChem
US-5036067-A chemical patent summary.
https://pubchem.ncbi.nlm.nih.gov/patent/US-5036067-A
A patient case highlighting the myriad of cutaneous adverse effects of prolonged use of hydroxyureaA patient case highlighting the myriad of cutaneous adverse effects of prolonged use of hydroxyurea
The adversereactions observed were acknowledged to be related to chronic hydroxyurea use. The patient underwent Mohs excision ... We report a case that exemplifies the cutaneous adverse effects of chronic hydroxyurea therapy. Although many cases improve ... given the recently proposed premalignant potential of dermatomyositis-like eruptions and the aggressive nature of hydroxyurea- ... Hydroxyurea is an antimetabolite primarily used to treat myeloproliferative disorders, and chronic treatment is associated with ...
https://dermatology.cdlib.org/uc/item/8h64503t
Hydroxyurea for sickle cell disease: A systematic review for efficacy and toxicity in children<...
Strouse, JJ, Lanzkron, S, Beach, MC, Haywood, C, Park, H, Witkop, C, Wilson, RF, Bass, EB & Segal, JB 2008, Hydroxyurea for ... Hydroxyurea for sickle cell disease : A systematic review for efficacy and toxicity in children. / Strouse, John J.; Lanzkron, ... Severe adverse events were rare and not clearly attributable to hydroxyurea. CONCLUSIONS. Hydroxyurea reduces hospitalization ... Severe adverse events were rare and not clearly attributable to hydroxyurea. CONCLUSIONS. Hydroxyurea reduces hospitalization ...
https://jhu.pure.elsevier.com/en/publications/hydroxyurea-for-sickle-cell-disease-a-systematic-review-for-effic-3
Chronic Myelogenous Leukemia (CML) Treatment & Management: Approach Considerations, Imatinib Mesylate, Newer Tyrosine Kinase...Chronic Myelogenous Leukemia (CML) Treatment & Management: Approach Considerations, Imatinib Mesylate, Newer Tyrosine Kinase...
Hydroxyurea. Hydroxyurea (Hydrea), an inhibitor of deoxynucleotide synthesis, is the most common myelosuppressive agent used to ... The chronic phase varies in duration, depending on the maintenance therapy used: it usually lasts 2-3 years with hydroxyurea ( ... TKI therapy should be started immediately after confirmation of BCR-ABL1 positivity, and the hydroxyurea dose tapered before ... European Society for Medical Oncology (ESMO) guidelines suggest that hydroxyurea (40 mg/kg daily) may be used as initial ...
https://www.medscape.com/answers/199425-167695/what-are-the-mortality-rates-for-chronic-myelogenous-leukemia-cml-following-allogeneic-bmt
HealthMatch - HydroxyureaHealthMatch - Hydroxyurea
Hydroxyurea treats many types of head and neck cancers, including cancers of the cheek, tongue, mouth, tonsils, throat, and ... Hydroxyurea and pregnancy. Do not use hydroxyurea during pregnancy. It is not known if it is safe, and more research on humans ... What is hydroxyurea?. Hydroxyurea is an anti-cancer drug. It is used alone or with radiation therapy to treat some cancers, ... What is hydroxyurea used to treat?. Hydroxyurea treats many types of head and neck cancers, including cancers of the cheek, ...
https://healthmatch.io/medications/hydroxyurea
Thalidomide + Hydroxyurea combination
Ive been using Hydroxyurea for 3 months along with multivitamins, L carnitine, wheatgrass and kalonji. Pre Hydrea I was ... Re: Thalidomide + Hydroxyurea combination « Reply #1 on: December 30, 2018, 01:26:43 PM » ... Re: Thalidomide + Hydroxyurea combination « Reply #2 on: December 31, 2018, 04:24:17 AM » ... Re: Thalidomide + Hydroxyurea combination « Reply #3 on: January 01, 2019, 08:41:09 PM » ...
https://www.thalassemiapatientsandfriends.com/index.php?topic=6003.msg55647
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https://www.cancer.gov/types/leukemia/hp/cml-treatment-pdqhttps://www.cancer.gov/types/leukemia/hp/cml-treatment-pdq
Hydroxyurea. Hydroxyurea is given daily by mouth (1-3 g per day as a single dose on an empty stomach). Hydroxyurea is superior ... Hydroxyurea.. *Splenectomy may be required and useful in patients having hematologic problems and physical discomfort from a ... When the WBC count drops below 20,000 mm3, the hydroxyurea is often reduced and titrated to maintain a WBC count between 5,000 ... Hydroxyurea is currently used primarily to stabilize patients with hyperleukocytosis or as palliative therapy for patients who ...
https://www.cancer.gov/types/leukemia/hp/cml-treatment-pdq
Hydroxyurea/therapeutic use | Ian..."Hydroxyurea/therapeutic use" | Ian...
"Hydroxyurea/therapeutic use". Regular long-term red blood cell transfusions for managing chronic chest complications in sickle ...
https://ianhambleton.com/tag/hydroxyurea/therapeutic-use/
24. Hydroxyurea - PIXORIZE Pharmacology 2021 | freemedtube24. Hydroxyurea - PIXORIZE Pharmacology 2021 | freemedtube
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https://medtube.store/shortcourse/PIXORIZE-Pharmacology-2021/24.%20Hydroxyurea.html
Benefits and Risks of Gene Therapy for Sickle CellBenefits and Risks of Gene Therapy for Sickle Cell
Hydroxyurea The most commonly used treatment for sickle cell disease is hydroxyurea. It helps the body keep producing another ... People taking hydroxyurea need to have their blood counts regularly monitored. Hydroxyurea also doesnt seem to work well for ... Hydroxyurea has relatively few side effects, but it must be taken daily, or else the person is at risk for sickle cell events. ... Nevitt SJ, Jones AP, Howard J. Hydroxyurea (Hydroxycarbamide) for sickle cell disease. Cochrane Database Syst Rev. 2017;2017(4 ...
https://www.verywellhealth.com/gene-therapy-for-sickle-cell-disease-4588187
Hydroxyurea | Medicamento | Listas Anotadas de Medicamentos e Dispositivos
CUADRO BÁSICO DE MEDICAMENTOS 2018. Ministerio de Salud Pública ...
https://medlistapp.paho.org/pt/medicine/463/?section=2124
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Hydroxyurea Syrup 100 mg/mL* in: Extemporaneous FormulationsHydroxyurea Syrup 100 mg/mL* in: Extemporaneous Formulations
Hydroxyurea Syrup 100 mg/mL* published on Jan 2022 by ASHP. ... Chemical and functional analysis of hydroxyurea oral solutions ... Heeney MM, Whorton MR, Howard TA, et al.Chemical and functional analysis of hydroxyurea oral solutions. J Pediatr Hematol Oncol ... Referenced Manufacturers - Hydroxyurea capsules (Hydrea, Bristol-Myers Squibb); Syrpalta, dye-free (Humco); sterile water for ...
https://publications.ashp.org/display/book/9781585286522/ch78.xml?rskey=BZ3ahe&result=124
Sickle Cell Disease (SCD) Treatment & Management: Approach Considerations, Hydroxyurea Therapy, Transfusion
Hydroxyurea Therapy. Hydroxyurea has an established role as a safe and effective treatment for SCD. [70] Hydroxyurea increases ... Hydroxyurea may decrease the frequency and severity of pain episodes. [71] The safety of long-term hydroxyurea use in children ... Hydroxyurea is usually prescribed by a hematologist, using rigorous selection criteria. Indications for hydroxyurea include the ... Hydroxyurea for children with sickle cell disease. Pediatr Clin North Am. 2008 Apr. 55(2):483-501, x. [QxMD MEDLINE Link]. ...
https://www.staging.medscape.com/answers/205926-15522/are-there-activity-restrictions-for-patients-with-sickle-cell-disease-scd
Sickle Cell DiHydreaConsidering hydroxyurea therapyEffect of hydroxyurea2018Take hydroxyureaTherapyDosesDoseEfficacyFrequency of painful crisesTreat sickleDoctor or pharmacistMedicationCapsuleInterventionPolycythemia veraTranscranial dopplerPediatricHydroxylamineOverdoseAttributableCyclosporineTreatsGeneticCutaneousObservationalHospitalizationAntineoplasticMedicationsClinical trialFetal hemoglobinPillMedicinesIncidenceIncreasesLiverChildrenTreatmentPreventsEffectsCancerPatientsSignificantlyDrugMechanismStudy
Sickle Cell Di9
  • During 2006-2016, the use of hydroxyurea (HU) among Medicaid beneficiaries with sickle cell disease (SCD) who lived in California or Georgia increased. (cdc.gov)
  • The Hydroxyurea Clinic at Nationwide Children's Hospital follows children with sickle cell disease who take hydroxyurea, the only disease modifying medication for sickle cell disease. (nationwidechildrens.org)
  • Hydroxyurea is the only approved medication for the treatment of sickle cell disease in adults;there are no approved drugs for children. (elsevier.com)
  • Our goal was to synthesize the published literature on the efficacy, effectiveness, and toxicity of hydroxyurea in children with sickle cell disease. (elsevier.com)
  • We selected randomized trials, observational studies, and case reports (English language only) that evaluated the efficacy and toxicity of hydroxyurea in children with sickle cell disease. (elsevier.com)
  • In 1998, the FDA approved hydroxyurea to treat sickle cell anemia (also called sickle cell disease, or SCD). (healthmatch.io)
  • Hydroxyurea (HU) has been shown to reduce the frequency of vaso-occlusive manifestations in both adults and children with sickle cell disease (SCD), and the induction of hemoglobin F (HbF) is thought to be the underlying mechanism responsible for clinical improvement in some Patients. (hacettepe.edu.tr)
  • Differences in health-related quality of life in children with sickle cell disease receiving hydroxyurea. (bvsalud.org)
  • OBJECTIVE: to estimate survival, mortality and cause of death among users or not of hydroxyurea with sickle cell disease. (bvsalud.org)
Hydrea2
  • The chronic phase varies in duration, depending on the maintenance therapy used: it usually lasts 2-3 years with hydroxyurea (Hydrea) or busulfan therapy, but it may last for longer than 9.5 years in patients who respond well to interferon-alfa therapy. (medscape.com)
  • Hydroxyurea is a generic medication, also available under the brand names Droxia, Siklos, and Hydrea. (healthmatch.io)
Considering hydroxyurea therapy1
  • These data provide important safety and efficacy information for clinicians considering hydroxyurea therapy for very young children with sickle cell anemia. (druglib.com)
Effect of hydroxyurea2
  • The study, "Adverse effect of hydroxyurea on spermatogenesis in patients with sickle cell anemia after six months of treatment," was published in the journal Blood. (onescdvoice.com)
  • The effect of hydroxyurea on the coagula. (hacettepe.edu.tr)
20181
  • In 2018, the patient began treatment with hydroxyurea due to worsening anemia, leukocytosis, and splenomegaly. (ajmc.com)
Take hydroxyurea3
Therapy5
  • Skin ulcers have been seen in patients taking hydroxyurea therapy. (rxwiki.com)
  • Conclusions: We report a case that exemplifies the cutaneous adverse effects of chronic hydroxyurea therapy. (cdlib.org)
  • The clinical trial determined that hydroxyurea therapy is feasible to use and safe for children in sub-Saharan Africa. (debuglies.com)
  • In addition, inhibition of PDE9, an enzyme highly expressed in hematopoietic cells, amplified the cGMP-elevating effects of hydroxyurea and may represent a promising and more tissue-specific adjuvant therapy for this disease. (elsevier.com)
  • RUX was restarted after surgery at a reduced dose, but the patient developed a progressive hyperleukocytosis and was started on cytoreductive therapy with hydroxyurea to reduce the risk of hyperviscosity syndrome. (ajmc.com)
Doses3
  • The hydroxyurea 1,000-mg tablets (Siklos) are scored so that they can easily be split into halves or quarters to provide smaller doses. (medlineplus.gov)
  • Researchers found that treatment with hydroxyurea at currently approved doses for sickle cell anemia leads to a significant drop in total sperm count in men. (onescdvoice.com)
  • Treatment with hydroxyurea is performed at varying doses at different intervals of time. (qscience.com)
Dose11
  • Your doctor may need to change your dose or tell you to stop taking hydroxyurea for a period of time to allow your blood count to return to normal if it has dropped too low. (medlineplus.gov)
  • Your doctor may need to delay your treatment or adjust your dose of hydroxyurea depending on your response to treatment and any side effects that you may experience. (medlineplus.gov)
  • If you are unable to swallow hydroxyurea tablets or portion(s) of tablets, you may dissolve your dose in water. (medlineplus.gov)
  • Your hydroxyurea dose will require adjustment based on these regular blood counts. (rxwiki.com)
  • Serious problems can occur if the hydroxyurea dose is not adjusted on time. (rxwiki.com)
  • Your doctor will recommend you have blood tests every two to three months while taking hydroxyurea once a stable dose is established. (healthmatch.io)
  • The primary goal of the Phase II EXTEND trial is to investigate the effects of open-label hydroxyurea treatment, escalated to maximum tolerated dose, for children with Sickle Cell Anemia and either conditional (170 - 199 cm/sec) or abnormal (≥200 cm/sec) Transcranial Doppler velocities. (clinicaltrials.gov)
  • Hydroxyurea will be titrated to the maximum tolerated dose as defined by mild marrow suppression, even if the participant has clinical well-being at a lower hydroxyurea dose. (clinicaltrials.gov)
  • After reaching maximum tolerated dose, minor hydroxyurea dose adjustments can be made periodically, as necessary based on weight changes and blood counts, to maintain the optimal laboratory response and to prevent dose-related toxicity. (clinicaltrials.gov)
  • For hydroxyurea dosing, the current body weight will be used, with dose escalations guided by hematological toxicity. (clinicaltrials.gov)
  • Future participants will begin at a lower dose of hydroxyurea (10 ± 2.5 mg/kg), with another 53 participants recruited of the same safety analysis. (who.int)
Efficacy3
  • It is also not known if hydroxyurea, used to potentiate the antiviral efficacy of these drugs, may also increase the risk of neuropathy. (nih.gov)
  • There was inadequate evidence to assess the efficacy of hydroxyurea in other groups. (elsevier.com)
  • Efficacy of Hydroxyurea The efficacy of hydroxyurea will be primarily assessed through fetal hemoglobin (HbF), comparing treatment with baseline values. (who.int)
Frequency of painful crises2
  • Hydroxyurea (Droxia, Siklos) is used to reduce the frequency of painful crises and reduce the need for blood transfusions in adults and children 2 years of age and older with sickle cell anemia (an inherited blood disorder in which the red blood cells are abnormally shaped [shaped like a sickle] and cannot bring enough oxygen to all parts of the body). (medlineplus.gov)
  • Hydroxyurea reduces the frequency of painful crises and reduces the need for blood transfusions. (rxwiki.com)
Treat sickle1
  • Hydroxyurea capsules are used to treat sickle cell anemia in adults. (rxwiki.com)
Doctor or pharmacist1
  • Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with hydroxyurea and each time you refill your prescription. (medlineplus.gov)
Medication4
  • Hydroxyurea is a prescription medication used to reduce the frequency of episodes of severe pain from sickle cell anemia and to reduce the need for blood transfusions in adults with sickle cell anemia. (rxwiki.com)
  • As with other medicines, hydroxyurea may cause unwanted effects, although it is not always possible to tell whether such effects are caused by hydroxyurea, another medication you may be taking, or your sickle cell anemia . (rxwiki.com)
  • Almost all patients who received hydroxyurea in clinical studies needed to have their medication stopped for a time to allow their low blood counts to return to acceptable levels. (rxwiki.com)
  • Medication Adherence and the Ability for Families to Adhere to Monthly Clinic Visits Hydroxyurea treatment will be dispensed only 35 days at a time, requiring a clinic visit every 4 ± 1 weeks. (who.int)
Capsule1
  • Hydroxyurea comes as a capsule and tablet to take by mouth. (medlineplus.gov)
Intervention1
  • A small intervention like Hydroxyurea can make a big impact on mortality [or incidence of death] in places where it is really high. (medlineplus.gov)
Polycythemia vera2
  • A 52-week interim analysis confirmed previous findings highlighting the benefits of ruxolitinib in patients with polycythemia vera (PV) who are resistant or intolerant to hydroxyurea. (ajmc.com)
  • Patients with polycythemia vera (PV) who are resistant or intolerant to hydroxyurea (HU) may benefit from being treated with ruxolitinib, according to an abstract presented at the European Hematology Association's annual meeting. (ajmc.com)
Transcranial doppler1
  • Despite recent improvements, many children with sickle cell anemia are still not receiving transcranial doppler ultrasound screenings and/or using hydroxyurea. (cdc.gov)
Pediatric1
  • The Pediatric Hydroxyurea Phase 3 Clinical Trial (BABY HUG) was a phase 3 multicenter, randomized, double-blind, placebo-controlled clinical trial of hydroxyurea in infants (beginning at 9-18 months of age) with sickle cell anemia. (druglib.com)
Hydroxylamine1
  • The DPA3972-71 PAO1161 strain demonstrated impaired growth in the presence of stress-inducing agents hydroxylamine or hydroxyurea, thus suggesting the role of PA3972-71 in pathogen survival upon stress. (waw.pl)
Overdose2
  • If symptoms of overdose occur while taking Hydroxyurea, get emergency help immediately. (crimsonbowsci.org)
  • Symptoms of overdose are scaling of the skin on the hands and feet, severe darkening of skin color, soreness, sores in the mouth and on the lips, swelling of the palms and soles of the feet, violet flushing of the skin.Some of the side effects that can occur with Hydroxyurea may not need medical attention. (crimsonbowsci.org)
Attributable1
  • Severe adverse events were rare and not clearly attributable to hydroxyurea. (elsevier.com)
Cyclosporine1
  • Oral retinoids, cyclosporine, hydroxyurea, 6-thioguanine and methotrexate are considered as first line treatment for pustular psoriasis. (psoriasisexpert.org)
Treats2
  • Hydroxyurea treats cancer by slowing or stopping the growth of cancer cells in your body. (medlineplus.gov)
  • Hydroxyurea treats sickle cell anemia by helping to prevent formation of sickle-shaped red blood cells. (medlineplus.gov)
Genetic3
  • In laboratory tests, hydroxyurea causes changes in chromosomes and DNA (genetic material) that strongly suggest it can cause cancer in people, especially if it is taken for a long time. (rxwiki.com)
  • Objective: To reproduce the altered genetic conditions produced by Hydroxyurea treatment for the in-vitro induction of HbF using molecular genetic techniques. (qscience.com)
  • as molecular genetic techniques could be used to reproduce the effects of hydroxyurea without the actual administration of the drug. (qscience.com)
Cutaneous1
  • Background: Hydroxyurea is an antimetabolite primarily used to treat myeloproliferative disorders, and chronic treatment is associated with many cutaneous adverse effects ranging in severity from ichthyosis to aggressive nonmelanoma skin cancer. (cdlib.org)
Observational2
  • Ruxolitinib in PV patients resistant and/or intolerant to hydroxyurea: interim analysis of a European multi-centric observational study. (ajmc.com)
  • New and recurrent neurologic events were decreased in 3 observational studies of hydroxyurea compared with historical controls. (elsevier.com)
Hospitalization1
  • Hydroxyurea reduces hospitalization and increases total and fetal hemoglobin levels in children with severe sickle cell anemia. (elsevier.com)
Antineoplastic2
  • Hydroxyurea belongs to a group of drugs called antineoplastic agents. (rxwiki.com)
  • Hydroxyurea IUPAC nomenclature Hydroxyurea Classification Hydroxurea falls under the category of Antineoplastic cytotoxic drug. (gpatindia.com)
Medications2
  • Hydroxyurea is in a class of medications called antimetabolites. (medlineplus.gov)
  • Some other medications can increase your risk of experiencing serious side effects from hydroxyurea. (rxwiki.com)
Clinical trial1
  • This is what a large multinational clinical trial called REACH discovered when it tested daily hydroxyurea treatment in 606 children between the ages of 1 and 10 years old. (debuglies.com)
Fetal hemoglobin3
  • Fetal hemoglobin levels increased from 5%-10% to 15%-20% on hydroxyurea. (elsevier.com)
  • So the theory is that as Hydroxyurea destroys precursor cells, the bone marrow is forced to produce fetal hemoglobin, which is beneficial in HBSS patients. (crimsonbowsci.org)
  • Our findings indicate that hydroxyurea has immediate beneficial effects on the microvasculature in acute sickle-cell crises that are independent of the drug's fetal hemoglobin-elevating properties and probably involve the formation of intravascular nitric oxide. (elsevier.com)
Pill4
  • The side effects reported most often by adults with sickle cell anemia participating in studies of hydroxyurea included hair loss, skin rash, fever, stomach and/or bowel disturbances, weight gain, bleeding, virus infection, and discolored nails (melanonychia), but these were equally common in people getting a placebo (sugar pill). (rxwiki.com)
  • Home Health Care A daily hydroxyurea pill may finally bring some relief for young children. (debuglies.com)
  • A daily hydroxyurea pill may finally bring some relief for young children living with the painful and deadly blood disease sickle cell anemia (SCA) in resource-challenged sub-Saharan Africa, where the disease is prevalent and health care availability is suboptimal. (debuglies.com)
  • But when treated with hydroxyurea, a pill that helps relieve pain and can help patients live longer, the risk of malaria decreased by more than half. (medlineplus.gov)
Medicines2
  • While you are taking hydroxyurea capsules, you should inform your doctor of all prescription and over-the-counter medicines that you are taking. (rxwiki.com)
  • Like all medicines, hydroxyurea can cause some uncomfortable side effects. (healthmatch.io)
Incidence3
  • The purpose of this analysis is to investigate if the combination of ddl and d4T, with or without hydroxyurea, has a higher incidence of neuropathy than a single drug regimen. (nih.gov)
  • Incidence rates of development of neuropathy were calculated for each of five regimens: ddl (+/- hydroxyurea), ddl + d4T (+/- hydroxyurea), and d4T. (nih.gov)
  • The crude incidence rate of neuropathy ranged from 6.8 cases per 100 person-years for ddl to 28.6 cases per 100 person-years for ddl + d4T + hydroxyurea. (nih.gov)
Increases2
  • The combination of ddl + d4T also increases the risk of neuropathy but less than when hydroxyurea is included. (nih.gov)
  • Targeted education after an emergency department visit increases hydroxyurea initiation in children with sickle cell. (onescdvoice.com)
Liver1
  • The HYDROXYUREA was anticipatory liver ministry. (snn.gr)
Children1
  • Moreover,hydroxyurea(HU), a disease modifying agent for SCD, has not been specifically evaluated in malnourished children although it is known to bind pharmacologically to human serum albumin. (ashpublications.org)
Treatment6
  • An expert panel has released evidence-based guidelines for the treatment of SCD, including a strong recommendation that hydroxyurea and long-term, periodic blood transfusions should be used more often to treat patients. (medscape.com)
  • One of the main reasons for the improvement in mortality and morbidity in patients with SCA is treatment with hydroxyurea. (onescdvoice.com)
  • The primary endpoint will be measured after 18 months of hydroxyurea but treatment will continue until a common study termination date. (clinicaltrials.gov)
  • Hydroxyurea treatment: Participants will be treated with open-label hydroxyurea, available as 500 mg capsules or liquid (100 mg/mL). (clinicaltrials.gov)
  • In this study, an attempt is made to identify and characterise the altered gene expression pattern caused by hydroxyurea treatment through Differential Display Reverse Transcriptase PCR (DDRT-PCR) and Real Time PCR (Q-PCR). (qscience.com)
  • Methods: Blood is obtained from SCA patients at diagnosis and after treatment with hydroxyurea. (qscience.com)
Prevents2
  • Hydroxyurea prevents sickle-shaped red blood cells from forming. (healthmatch.io)
  • In sickle cell patients, hydroxyurea also prevents strokes and brain problems. (medlineplus.gov)
Effects3
  • Some of the common side effects of hydroxyurea include hair loss, fever, and stomach problems. (rxwiki.com)
  • The most serious side effects of hydroxyurea involve the blood and may include severely low white blood cell counts (leukopenia, neutropenia), which can decrease your resistance to infections, severely low red blood cell counts (anemia), or severely low platelet counts (thrombocytopenia), which can cause bleeding. (rxwiki.com)
  • Dr. Ware would like to see hydroxyurea, which has been used for 20 years with little to no side effects, become more affordable and available to everyone globally. (medlineplus.gov)
Cancer6
  • Hydroxyurea may increase the risk that you will develop other cancers, including skin cancer. (medlineplus.gov)
  • When hydroxyurea is used to treat certain types of cancer, it may be taken once every third day. (medlineplus.gov)
  • Skin cancer and leukemia , which can be fatal, have been reported in patients receiving long-term hydroxyurea for conditions other than sickle cell anemia. (rxwiki.com)
  • Although many cases improve after drug discontinuation, strict photoprotection and ongoing surveillance are indicated given the recently proposed premalignant potential of dermatomyositis-like eruptions and the aggressive nature of hydroxyurea-induced nonmelanoma skin cancer. (cdlib.org)
  • Hydroxyurea is an anti-cancer drug. (healthmatch.io)
  • You must use hydroxyurea for several months to treat cancer. (healthmatch.io)
Patients3
  • Used 25,000 Earth's article talked about moralism the HYDROXYUREA was not urbanized to work with dying patients. (snn.gr)
  • If patients with SCD crisis are being transported by emergency medical services (EMS), they should receive supplemental oxygen and intravenous hydration en route to the hospital. (medscape.com)
  • Introduction: La mise en place depuis Septembre 2016 au Centre Hospitalier Universitaire (CHUL) d'une consultation d'hématologie dédiée aux adultes drépanocytaires a été l'occasion de mener cette étude dont le but principal était d'établir les profils clinique et paraclinique de l'adulte drépanocytaire régulièrement suivi.Patients et méthodes : Il s'agissait d'une étude rétrospective. (bvsalud.org)
Significantly1
  • Using a humanized SCD-mouse-model of tumor necrosis factor-α-induced acute vaso-occlusion, we herein present data demonstrating that short-term administration of either hydroxyurea or the phosphodiesterase 9 (PDE9) inhibitor, BAY73-6691, significantly altered leukocyte recruitment to the microvasculature. (elsevier.com)
Drug2
  • Hydroxyurea (HU) is the most common drug used for the management of sickle-cell anemia but not thalassemia. (medrxiv.org)
  • We have gotten a lot of questions about the drug Hydroxyurea and if its it is dangerous for people living with Sickle Cell to use it. (crimsonbowsci.org)
Mechanism1
  • Our results suggest that increased mRNA stability is the major mechanism of p21 WAF/CIP1/SDI1 elevation in the hydroxyurea-induced growth arrest of human fibroblasts. (ewha.ac.kr)
Study1
  • An important secondary objective of this study was to compare clinical events between the hydroxyurea and placebo groups. (druglib.com)
Chronic Myelogenous Leukemia (CML) Treatment & Management: Approach Considerations, Imatinib Mesylate, Newer Tyrosine Kinase...
Chronic Myelogenous Leukemia (CML) Treatment & Management: Approach Considerations, Imatinib Mesylate, Newer Tyrosine Kinase... (medscape.com)
Pediatric Non-Hodgkin Lymphoma Medication: Antineoplastics, Other, Antineoplastics, Monoclonal Antibodies, PD-1/PD-L1...
Pediatric Non-Hodgkin Lymphoma Medication: Antineoplastics, Other, Antineoplastics, Monoclonal Antibodies, PD-1/PD-L1... (medscape.com)
(emedicine.medscape.com)
CDC's Sickle Cell Data Collection (SCDC) Data Brief: Hydroxyurea | CDC
CDC's Sickle Cell Data Collection (SCDC) Data Brief: Hydroxyurea | CDC (cdc.gov)
Benefits and Risks of Gene Therapy for Sickle Cell
Benefits and Risks of Gene Therapy for Sickle Cell (verywellhealth.com)
PRIME PubMed | [A hydroxyurea-induced leg ulceration]
PRIME PubMed | [A hydroxyurea-induced leg ulceration] (unboundmedicine.com)
Tumor Lysis Syndrome: Practice Essentials, Pathophysiology, Etiology
Tumor Lysis Syndrome: Practice Essentials, Pathophysiology, Etiology (medscape.com)
Hydroxyurea: MedlinePlus Drug Information
Hydroxyurea: MedlinePlus Drug Information (medlineplus.gov)
Pediatric Non-Hodgkin Lymphoma: Practice Essentials, Etiology, Epidemiology
Pediatric Non-Hodgkin Lymphoma: Practice Essentials, Etiology, Epidemiology (medscape.com)
Keyfinding: Hydroxyurea treatment and young children with sickle cell anemia | CDC
Keyfinding: Hydroxyurea treatment and young children with sickle cell anemia | CDC (cdc.gov)
Publications | Max Planck Institute of Biochemistry
Publications | Max Planck Institute of Biochemistry (biochem.mpg.de)
Sickle Cell Disease (SCD) Workup: Approach Considerations, Baseline Blood Study Abnormalities, Suggested Routine Clinical...
Sickle Cell Disease (SCD) Workup: Approach Considerations, Baseline Blood Study Abnormalities, Suggested Routine Clinical... (medscape.com)
Renal Manifestations of Sickle Cell Disease: Overview, Prognosis, Glomerular Abnormalities
Renal Manifestations of Sickle Cell Disease: Overview, Prognosis, Glomerular Abnormalities (medscape.com)
SCD: Algorithm Improves Veno-occlusive Episode Care in Kids
SCD: Algorithm Improves Veno-occlusive Episode Care in Kids (medscape.com)
Gene Therapy Treats Sickle Cell Disease in Teenager
Gene Therapy Treats Sickle Cell Disease in Teenager (medscape.com)
New Therapy May Offer 'Functional Cure' for Two Blood Disorders
New Therapy May Offer 'Functional Cure' for Two Blood Disorders (medscape.com)
Sickle Cell Disease (SCD) Medication: Antimetabolites, Opioid Analgesics, Nonsteroidal Analgesics, Tricyclic Antidepressants,...
Sickle Cell Disease (SCD) Medication: Antimetabolites, Opioid Analgesics, Nonsteroidal Analgesics, Tricyclic Antidepressants,... (medscape.com)