AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and Processes
HydroxyprolineCollagenProlineHydroxylysineProcollagen-Proline DioxygenasePulmonary FibrosisBleomycinOsteitis DeformansUronic AcidsLiver Cirrhosis, ExperimentalPlant Somatic Embryogenesis TechniquesMicrobial CollagenaseAscorbic Acid DeficiencyAmino AcidsDesmosineProcollagenOxalatesPeplomycinCollagen Type IIIHydroxylationGlycolatesWound HealingCarbon TetrachlorideCollagen Type IGalactansBone and BonesFibrosisBone ResorptionLungAlkaline PhosphataseAnastomosis, SurgicalAmino Acid Metabolism, Inborn ErrorsGlycosaminoglycansLiver CirrhosisPhosphorusArabinoseDisease Models, AnimalProline OxidaseMusaRats, WistarHyperoxaluriaAntibodiesAntibody SpecificityAntibodies, MonoclonalRabbitsAntibodies, ViralAntibodies, BacterialCentrifugationTransition TemperatureAntibodies, ArchaealAntigens, ArchaealSolvents
Hydroxyproline: A hydroxylated form of the imino acid proline. A deficiency in ASCORBIC ACID can result in impaired hydroxyproline formation.Collagen: A polypeptide substance comprising about one third of the total protein in mammalian organisms. It is the main constituent of SKIN; CONNECTIVE TISSUE; and the organic substance of bones (BONE AND BONES) and teeth (TOOTH).Proline: A non-essential amino acid that is synthesized from GLUTAMIC ACID. It is an essential component of COLLAGEN and is important for proper functioning of joints and tendons.Hydroxylysine: A hydroxylated derivative of the amino acid LYSINE that is present in certain collagens.Procollagen-Proline Dioxygenase: A mixed-function oxygenase that catalyzes the hydroxylation of a prolyl-glycyl containing peptide, usually in PROTOCOLLAGEN, to a hydroxyprolylglycyl-containing-peptide. The enzyme utilizes molecular OXYGEN with a concomitant oxidative decarboxylation of 2-oxoglutarate to SUCCINATE. The enzyme occurs as a tetramer of two alpha and two beta subunits. The beta subunit of procollagen-proline dioxygenase is identical to the enzyme PROTEIN DISULFIDE-ISOMERASES.Pulmonary Fibrosis: A process in which normal lung tissues are progressively replaced by FIBROBLASTS and COLLAGEN causing an irreversible loss of the ability to transfer oxygen into the bloodstream via PULMONARY ALVEOLI. Patients show progressive DYSPNEA finally resulting in death.Bleomycin: A complex of related glycopeptide antibiotics from Streptomyces verticillus consisting of bleomycin A2 and B2. It inhibits DNA metabolism and is used as an antineoplastic, especially for solid tumors.Osteitis Deformans: A disease marked by repeated episodes of increased bone resorption followed by excessive attempts at repair, resulting in weakened, deformed bones of increased mass. The resultant architecture of the bone assumes a mosaic pattern in which the fibers take on a haphazard pattern instead of the normal parallel symmetry.Uronic Acids: Acids derived from monosaccharides by the oxidation of the terminal (-CH2OH) group farthest removed from the carbonyl group to a (-COOH) group. (From Stedmans, 26th ed)Liver Cirrhosis, Experimental: Experimentally induced chronic injuries to the parenchymal cells in the liver to achieve a model for LIVER CIRRHOSIS.Plant Somatic Embryogenesis Techniques: The process of embryo initiation in culture from vegetative, non-gametic, sporophytic, or somatic plant cells.Microbial Collagenase: A metalloproteinase which degrades helical regions of native collagen to small fragments. Preferred cleavage is -Gly in the sequence -Pro-Xaa-Gly-Pro-. Six forms (or 2 classes) have been isolated from Clostridium histolyticum that are immunologically cross-reactive but possess different sequences and different specificities. Other variants have been isolated from Bacillus cereus, Empedobacter collagenolyticum, Pseudomonas marinoglutinosa, and species of Vibrio and Streptomyces. EC 3.4.24.3.Ascorbic Acid Deficiency: A condition due to a dietary deficiency of ascorbic acid (vitamin C), characterized by malaise, lethargy, and weakness. As the disease progresses, joints, muscles, and subcutaneous tissues may become the sites of hemorrhage. Ascorbic acid deficiency frequently develops into SCURVY in young children fed unsupplemented cow's milk exclusively during their first year. It develops also commonly in chronic alcoholism. (Cecil Textbook of Medicine, 19th ed, p1177)Amino Acids: Organic compounds that generally contain an amino (-NH2) and a carboxyl (-COOH) group. Twenty alpha-amino acids are the subunits which are polymerized to form proteins.Desmosine: A rare amino acid found in elastin, formed by condensation of four molecules of lysine into a pyridinium ring.Procollagen: A biosynthetic precursor of collagen containing additional amino acid sequences at the amino-terminal and carboxyl-terminal ends of the polypeptide chains.Oxalates: Derivatives of OXALIC ACID. Included under this heading are a broad variety of acid forms, salts, esters, and amides that are derived from the ethanedioic acid structure.Peplomycin: An antineoplastic agent derived from BLEOMYCIN.Collagen Type III: A fibrillar collagen consisting of three identical alpha1(III) chains that is widely distributed in many tissues containing COLLAGEN TYPE I. It is particularly abundant in BLOOD VESSELS and may play a role in tissues with elastic characteristics.Hydroxylation: Placing of a hydroxyl group on a compound in a position where one did not exist before. (Stedman, 26th ed)Glycolates: Derivatives of ACETIC ACID which contain an hydroxy group attached to the methyl carbon.Wound Healing: Restoration of integrity to traumatized tissue.Carbon Tetrachloride: A solvent for oils, fats, lacquers, varnishes, rubber waxes, and resins, and a starting material in the manufacturing of organic compounds. Poisoning by inhalation, ingestion or skin absorption is possible and may be fatal. (Merck Index, 11th ed)Collagen Type I: The most common form of fibrillar collagen. It is a major constituent of bone (BONE AND BONES) and SKIN and consists of a heterotrimer of two alpha1(I) and one alpha2(I) chains.Galactans: Polysaccharides composed of repeating galactose units. They can consist of branched or unbranched chains in any linkages.Bone and Bones: A specialized CONNECTIVE TISSUE that is the main constituent of the SKELETON. The principle cellular component of bone is comprised of OSTEOBLASTS; OSTEOCYTES; and OSTEOCLASTS, while FIBRILLAR COLLAGENS and hydroxyapatite crystals form the BONE MATRIX.Fibrosis: Any pathological condition where fibrous connective tissue invades any organ, usually as a consequence of inflammation or other injury.Bone Resorption: Bone loss due to osteoclastic activity.Lung: Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood.Alkaline Phosphatase: An enzyme that catalyzes the conversion of an orthophosphoric monoester and water to an alcohol and orthophosphate. EC 3.1.3.1.Anastomosis, Surgical: Surgical union or shunt between ducts, tubes or vessels. It may be end-to-end, end-to-side, side-to-end, or side-to-side.Amino Acid Metabolism, Inborn Errors: Disorders affecting amino acid metabolism. The majority of these disorders are inherited and present in the neonatal period with metabolic disturbances (e.g., ACIDOSIS) and neurologic manifestations. They are present at birth, although they may not become symptomatic until later in life.Glycosaminoglycans: Heteropolysaccharides which contain an N-acetylated hexosamine in a characteristic repeating disaccharide unit. The repeating structure of each disaccharide involves alternate 1,4- and 1,3-linkages consisting of either N-acetylglucosamine or N-acetylgalactosamine.Liver Cirrhosis: Liver disease in which the normal microcirculation, the gross vascular anatomy, and the hepatic architecture have been variably destroyed and altered with fibrous septa surrounding regenerated or regenerating parenchymal nodules.Phosphorus: A non-metal element that has the atomic symbol P, atomic number 15, and atomic weight 31. It is an essential element that takes part in a broad variety of biochemical reactions.ArabinoseDisease Models, Animal: Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.Proline Oxidase: The first enzyme of the proline degradative pathway. It catalyzes the oxidation of proline to pyrroline-5-carboxylic acid in the presence of oxygen and water. The action is not reversible. The specific activity of proline oxidase increases with age. EC 1.5.3.-.Musa: A plant genus of the family Musaceae, order Zingiberales, subclass Zingiberidae, class Liliopsida.Rats, Wistar: A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain.Hyperoxaluria: Excretion of an excessive amount of OXALATES in the urine.Antibodies: Immunoglobulin molecules having a specific amino acid sequence by virtue of which they interact only with the ANTIGEN (or a very similar shape) that induced their synthesis in cells of the lymphoid series (especially PLASMA CELLS).Antibody Specificity: The property of antibodies which enables them to react with some ANTIGENIC DETERMINANTS and not with others. Specificity is dependent on chemical composition, physical forces, and molecular structure at the binding site.Antibodies, Monoclonal: Antibodies produced by a single clone of cells.Rabbits: The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.Antibodies, Viral: Immunoglobulins produced in response to VIRAL ANTIGENS.Antibodies, Bacterial: Immunoglobulins produced in a response to BACTERIAL ANTIGENS.Centrifugation: Process of using a rotating machine to generate centrifugal force to separate substances of different densities, remove moisture, or simulate gravitational effects. It employs a large motor-driven apparatus with a long arm, at the end of which human and animal subjects, biological specimens, or equipment can be revolved and rotated at various speeds to study gravitational effects. (From Websters, 10th ed; McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Transition Temperature: The temperature at which a substance changes from one state or conformation of matter to another.Antibodies, Archaeal: Immunoglobulins produced in a response to ARCHAEAL ANTIGENS.Antigens, Archaeal: Substances of archaeal origin that have antigenic activity.Solvents: Liquids that dissolve other substances (solutes), generally solids, without any change in chemical composition, as, water containing sugar. (Grant & Hackh's Chemical Dictionary, 5th ed)

Variations in 35SO4 incorporation into glycosaminoglycans along canine coronary arteries. A possible index of artery wall stress. (1/1144)

Focal areas of accentuated wall stress along the course of canine coronary arteries may be revealed by the level of 35SO4 incorporation into glycosaminoglycans (GAG). In the anterior descending artery, 35SO4 incorporation in higher in the proximal than in the distal region and may be extraordinarily high as the vessel enters a proximally located muscle bridge and at the takeoff region of multidirectional branches. In the circumflex artery, the incorporation also is higher in the proximal than in the distal region and is high at the genu where the posterior descending artery forms. There are differences in uptake of 35SO4 in vessels even when the arteries arise from the same vascular bed.this was shown by the higher incorporation in the left coronary artery than in the right coronary artery. A general anatomical agreement exists between these sites of high 35SO4 incorporation and previously described locations of interval elastic disruption ans proliferation of intimal connective tissue in the dog.  (+info)

Suppression of experimental abdominal aortic aneurysms by systemic treatment with a hydroxamate-based matrix metalloproteinase inhibitor (RS 132908). (2/1144)

BACKGROUND: Abdominal aortic aneurysms (AAAs) are associated with chronic inflammation, disruption of medial elastin, and increased local production of elastolytic matrix metalloproteinases (MMPs). The purpose of this study was to investigate how treatment with a hydroxamate-based MMP antagonist (RS 132908) might affect the development of experimental AAAs. METHODS: Male Wistar rats underwent intraluminal perfusion of the abdominal aorta with 50 units of porcine pancreatic elastase followed by treatment for 14 days with RS 132908 (100 mg/kg/day subcutaneously; n = 8) or with vehicle alone (n = 6). The external aortic diameter (AD) was measured in millimeters before elastase perfusion and at death, with AAA defined as an increase in AD (DeltaAD) of at least 100%. Aortic wall elastin and collagen concentrations were measured with assays for desmosine and hydroxyproline, and fixed aortic tissues were examined by light microscopy. RESULTS: AAAs developed in all vehicle-treated rats, with a mean AD (+/- SE) that increased from 1.60 +/- 0.03 mm before perfusion to 5.98 +/- 1.02 mm on day 14 (DeltaAD = 276.4 +/- 67.7%). AAAs developed in only five of eight animals (62.5%) after MMP inhibition, with a mean AD that increased from 1.56 +/- 0.05 mm to 3.59 +/- 0.34 mm (DeltaAD = 128.1 +/- 18.7%; P <.05, vs vehicle). The overall inhibition of aortic dilatation attributable to RS 132908 was 53.6 +/- 6.8%. Aortic wall desmosine fell by 85.4% in the vehicle-treated rats (1210.6 +/- 87.8 pmol/sample to 176.7 +/- 33.4 pmol/sample; P <.05) but only by 65.6% in the animals treated with RS 312908 (416.2 +/- 120.5 pmol/sample). In contrast, hydroxyproline was not significantly affected by either elastase perfusion or drug treatment. Microscopic examination revealed the preservation of pericellular elastin and a greater degree of fibrocollagenous wall thickening after MMP inhibition, with no detectable difference in the extent of inflammation. CONCLUSIONS: Systemic MMP inhibition suppresses aneurysmal dilatation in the elastase-induced rodent model of AAA. Consistent with its direct inhibitory effect on various MMPs, RS 132908 promotes the preservation of aortic elastin and appears to enhance a profibrotic response within the aortic wall. Hydroxamate-based MMP antagonists may therefore be useful in the development of pharmacologic approaches to the suppression of AAAs.  (+info)

Altered connective tissue in children with congenital dislocation of the hip. (3/1144)

The umbilical cord was employed as a source of collagen in 10 children with congenital dislocation of hip. The amount of collagen and its solubility were measured in slices of the cords and in the umbilical veins and compared with the values in normal subjects. Both the amount of collagen and its solubility were decreased in children with congenital dislocation of the hip.  (+info)

Effects of pirfenidone on procollagen gene expression at the transcriptional level in bleomycin hamster model of lung fibrosis. (4/1144)

A time course study was carried out to elucidate the mechanisms for antifibrotic effect of pirfenidone (PD). Hamsters were intratracheally (i.t.) instilled with saline (SA) or bleomycin (BL) (7.5 units/kg/5 ml). The animals were fed a diet containing 0.5% PD or the same control diet (CD) without the drug 2 days before and throughout the study. The animals were sacrificed at various times after instillation. The lung hydroxyproline level in BL + CD groups was gradually increased and peaked at 21 days to 181% of the SA + CD control. The BL + PD-treated groups showed a gradual decrease in their lung collagen content, showing a maximum reduction of 40% at day 21. The lung malondialdehyde levels of the BL + CD groups were increased by several-fold of the corresponding SA + CD groups at various times. The lung prolyl hydroxylase (PH) activities in the BL + CD groups were also increased by several-fold of the corresponding SA + CD groups at these time points. The hamsters in the BL + PD showed a gradual decrease in the lung malondialdehyde levels from 10 to 21days compared with their corresponding BL + CD groups. Treatment with PD also reduced the lung PH activities in the BL + PD groups compared with the corresponding BL + CD groups. However, PD failed to manifest any direct inhibitory effect on PH activity in vitro. BL treatment increased the lung procollagen I and III gene expressions in the BL + CD groups by several-fold at varying times compared with the corresponding SA + CD, and treatment with PD in the BL + PD groups significantly down-regulated the BL-induced overexpression of these genes. Studies evaluating the regulation of these genes at the transcriptional level revealed PD significantly reduced the transcription of PC I at 14 days. Our results indicate that the antifibrotic effect of PD was partly due to suppression of the BL-induced inflammatory events and partly due to down-regulation of BL-induced overexpression of lung procollagen I and III genes.  (+info)

A new approach to assessing collagen turnover by using a micro-assay. A highly efficient and rapid turnover of collagen in rat periodontal tissues. (5/1144)

Measurement of [3H]proline incorporation into newly synthesized and mature collagen in connective tissues was used to compare rates and efficiency of collagen turnover. The approach minimizes label-recycling problems. By using a micro-assay to determine hydroxyproline specific radioactivities, a highly efficient and rapid collagen turnover in rat periodontal tissues was demonstrated.  (+info)

T cell independence of bleomycin-induced pulmonary fibrosis. (6/1144)

The role of T cells and cytokines in bleomycin (BLM)-induced fibrosis was evaluated in susceptible and resistant strains of normal and SCID mice. Histology and hydroxyproline analysis showed that BLM induced pulmonary fibrosis in C57BL/6 and (C57BL/6 x BALB/c)F1 mice, whereas BALB/c mice were resistant to the disease. To test whether lymphocytes were required for the induction of BLM-induced pulmonary fibrosis, SCID mice were injected intratracheally with BLM and evaluated for the development of pulmonary inflammation and fibrosis. Similar morphological changes and increases in hydroxyproline were observed in both C57BL/6 SCID and (C57BL/6 x CB.17)F1 SCID animals compared to those seen in wild-type C57BL/6 and (C57BL/6 x BALB/c)F1 mice. In contrast, CB.17 SCID mice, which are genetically similar to BALB/c mice, were resistant to disease induction. Analysis of the cellular infiltrate in BLM-treated C57Bl/6 SCID mice confirmed a lack of T cells in the lungs of SCID mice and demonstrated a pronounced accumulation of eosinophils in areas of developing pulmonary fibrosis. NK cells were significantly elevated in untreated SCID mice and did not increase further after BLM treatment. Analysis of selected cytokines 1 day after initiation of BLM-induced pulmonary fibrosis indicated that the levels of TNF-alpha and IFN-gamma appeared to segregate with fibrosis in both the SCID and wild-type mice. The data demonstrate that T cells are not required for the induction of fibrosis by BLM and suggest that responses by non-lymphoid cells may be sufficient for the induction of fibrosis.  (+info)

The action of the benzopyrones on an experimental model of lymphoedema: a contribution to their mode of action. (7/1144)

A number of preparations containing benzopyrones are used clinically as a therapy for lymphoedema; however, their exact mode of action is not well known. This work presents evidence which indicates that, as in the treatment of thermally induced oedemas, the benzopyrones work by enhancing the lysis of the accumulated proteins. This is evidenced by reduced levels of total protein in the extracellular compartment of the skin, while peptides and amino acids were increased in the serum at 6 and 12 h respectively after the drug's administration. Failure to observe very marked increases in peptides and amino acids at other times in the serum and skin was attributed to the rapid incorporation of these into the large number of maturing phagocytes which enter the lymphoedematous tissues. Likewise, protease activity levels were not elevated as expected. This possibly was the consequence of a number of factors including serum deactivation, inhibition of release and membrane stabilization.  (+info)

Histology and tissue chemistry of tidemark separation in hamsters. (8/1144)

Adult articular cartilage is divided by the tidemark into a deep calcified layer and a more superficial uncalcified layer. Histologic examination of articular cartilage from the knee joint of golden Syrian hamsters 123 days of age or older revealed defects at the tidemark in the tibia. Defects ranged from small separations of the calcified and uncalcified layers along the tidemark to progressively larger defects apparently formed by dissolution. These larger defects appeared as cavities in the noncalcified cartilage, had smooth rather than rough edges, frequently contained coalesced debris, and often resulted in a bulge in the articular surface. Occasionally, these large defects broke through the articular surface. Defects were not observed in tibial cartilage of younger (<90 days old) hamsters or in femoral cartilage from hamsters of any age. Exercise neither protected against nor increased the severity of the defects. Collagen cross-linking by pyridinoline was examined as a function of age and increased from 1,090 to 3,062 micromoles of pyridinoline/mole of hydroxyproline over the period of 1-9 months of age but was not correlated with defect formation. With increasing age, these focal tidemark defects could lead to osteoarthrosis-like cartilage lesions.  (+info)

Serial spot hydroxyproline/creatinine ratios in metastatic prostatic cancer<...Serial spot hydroxyproline/creatinine ratios in metastatic prostatic cancer<...
TY - JOUR. T1 - Serial spot hydroxyproline/creatinine ratios in metastatic prostatic cancer. AU - Hopkins, S. C.. AU - Nissenkorn, I.. AU - Palmieri, G. M.A.. AU - Ikard, M.. AU - Moinuddin, M.. AU - Soloway, M. S.. PY - 1983/1/1. Y1 - 1983/1/1. N2 - Analysis of urinary hydroxyproline levels offers a marker to monitor osseous involvement in patients with metastatic malignancies. Such a marker is needed in patients with prostatic cancer when bone metastases predominate. Thirty-two men with stage D2 prostatic cancer were monitored by bone scan, acid and alkaline phosphatase values, and urinary hydroxyproline, beginning from 4 to 36 months after initiation of hormonal manipulation and/or systemic chemotherapy. In patients with disease progression determined by bone scan serial urinary hydroxyproline values progressively increased and were significantly elevated compared to urinary values obtained from patients with a stable or improving scan (p ,0.001). Simultaneous alkaline phosphatase ...
China Trans-3-Hydroxy-L-Proline CAS: 4298-08-2 Amino Acid Pharmaceutical Grade Intermediates Photos & Pictures - Made-in-china...China Trans-3-Hydroxy-L-Proline CAS: 4298-08-2 Amino Acid Pharmaceutical Grade Intermediates Photos & Pictures - Made-in-china...
Trans-3-Hydroxy-L-Proline CAS: 4298-08-2 Amino Acid Pharmaceutical Grade Intermediates picture from Wuhan HengHeDa Pharm Co., Ltd. view photo of Trans-3-Hydroxy-L-Proline, 4298-08-2, Amino Acids.Contact China Suppliers for More Products and Price.
The synthetic hydroxyproline-containing collagen analogue (Gly-Pro-Hyp) 10 promotes enzymatic activity of...The synthetic hydroxyproline-containing collagen analogue (Gly-Pro-Hyp) 10 promotes enzymatic activity of...
Diseases such as liver fibrosis and intestinal inflammation are characterized by accumulated components of the extracellular matrix (ECM). Given that fibrillar collagen structures were shown to serve as storage site for inactive proforms of matrixmetalloproteinases (MMPs), modulating this MMP-collagen interaction might offer a rational interventional (therapeutic) approach to enhance degradation of accumulated ECM. The synthetic triple helical collagen analogue (Gly-Pro-Hyp) 10 - (GPO) 10 - was shown to trigger release and enzymatic activation of collagen sequestered proMMP-2. In the presented study, we, for the first time, investigated how MMP-(GPO) 10 interaction impacts cellular responses in vitro . We found that recombinant proMMP-2 induced proliferation of hepatic stellate cells (HSC), which was enhanced after addition of (GPO) 10 reaching comparable levels following incubation with fully activated MMP-2. In addition, (GPO) 10 induced HSC migration similar to the platelet-derived growth
Pagets Disease of Bone Treated with a Five Day Course of Oral Tiludronate - Reginster Jean-YvesPaget's Disease of Bone Treated with a Five Day Course of Oral Tiludronate - Reginster Jean-Yves
en] Chloro-4-phenyl thiomethylene bisphosphonate (tiludronate) is a new drug which can be used as an inhibitor of bone resorption. As it remains in bone for a long time, and as mineralisation defects have only been seen at doses much higher than those required to decrease osteoclastic activity, it could be given at high doses over a short period of time. Eighteen patients with Pagets disease of bone were randomly allocated to three therapeutic groups receiving respectively 600, 800, and 1200 mg/day tiludronate for five days. Serum alkaline phosphatase activity and the urinary hydroxyproline/creatinine ratio were quickly and drastically reduced in all three groups. A significant reduction of serum alkaline phosphatases and the hydroxyproline/creatinine ratio was still present six months after the five day therapeutic course, reflecting a sustained activity of tiludronate even after stopping treatment. Dose dependent short and long term reductions of bone turnover rate were observed. Biochemical ...
Plus itPlus it
We report data from three patients with severe Pagets disease of bone who were treated with mithramycin.. Mithramycin infusion resulted in a fall in plasma calcium, phosphate, alkaline phosphatase, and urinary hydroxyproline excretion. There was an improvement in calcium and phosphorus balance in two of the three subjects studied. A pronounced or complete relief of bone pain occurred in all three.. We suggest that mithramycin exerts its beneficial effect in Pagets disease of bone by stimulating parathyroid hormone release. The parathyroid hormone released has a predominantly anabolic action on bone since its catabolic action is blocked by mithramycin, which inhibits bone resorption.. ...
Solanum tuberosum - EY Laboratories, Inc.Solanum tuberosum - EY Laboratories, Inc.
Saline extracts of potato tubers contain a potent hemagglutininin that is not inhibited by monosaccharides. Carbohydrate inhibition studies have shown that the lectin has an extended binding site that can accommodate up to four carbohydrate units. The lectin binds oligosaccharides containing β(1,4)-linked GlcNAc. The tetrasaccharide is approximately 20 times more potent an inhibitor than the disaccharide 1 . STA also reacts with poly N-acetyllactosamine structures from N-linked oligosaccharides, albeit rather weakly 2 . Nevertheless, it is useful for histochemical staining of these structures 3 . Many lectins do not react with sulfated sugars, however, STA does bind to chitin sulfates and keratan sulfates 4 . Purified STA is one of the most highly glycosylated lectins, composed of approximately 50% carbohydrate by weight. The heavily-glycosylated portion is a hydroxyproline-containing sequence homologous to the cell wall extensions, while the carbohydrate-binding region is rich in cysteine and ...
Biology-Online • View topic - hydroxyprolineBiology-Online • View topic - hydroxyproline
Young (3 mo old) and old (18-24 mo old) wild-type (WT) and SPARC-null mice were studied. LV collagen content was measured histologically by collagen volume fraction, collagen composition was measured by hydroxyproline assay as soluble collagen (1 M NaCl extractable) versus insoluble collagen (mature cross-linked), and collagen morphological structure was examined by scanning electron microscopy ...
Network Portal - Function 4-hydroxyproline metabolic processNetwork Portal - Function 4-hydroxyproline metabolic process
Description: The chemical reactions and pathways involving 4-hydroxyproline, C5H9NO3, a derivative of the amino acid proline. The presence of hydroxyproline is essential to produce stable triple helical tropocollagen, hence the problems caused by ascorbate deficiency in scurvy. This unusual amino acid is also present in considerable amounts in the major glycoprotein of primary plant cell walls.. ...
I think I now know why STURP chemist Raymond Rogers detected hydroxyproline in the blood on the Shroud - and its to do with...I think I now know why STURP chemist Raymond Rogers detected hydroxyproline in the blood on the Shroud - and it's to do with...
Yup, Ive been expressing bewilderment for months now as to why STURPs Ray Rogers (left) thought there was hydroxyproline in human blood. He cited the presence of hydroxyproline as crucial evidence against the Shroud blood ever having been heated, using that to dismiss any idea that the body image was a thermal imprint (scorch) -…
Archive - Mar 18, 2020 | www.bioquicknews.comArchive - Mar 18, 2020 | www.bioquicknews.com
MIT and Harvard University chemists have discovered the structure of an unusual bacterial enzyme that can break down an amino acid found in collagen, which is the most abundant protein in the human body. The enzyme, known as hydroxy-L-proline dehydratase (HypD), has been found in a few hundred species of bacteria that live in the human gut, including Clostridioides difficile. The enzyme performs a novel chemical reaction that dismantles hydroxy-L-proline, the molecule that gives collagen its tough, triple-helix structure. Now that researchers know the structure of the enzyme, they can try to develop drugs that inhibit it. Such a drug could be useful in treating C. difficile infections, which are resistant to many existing antibiotics. "This is very exciting because this enzyme doesnt exist in humans, so it could be a potential target," says Catherine Drennan, PhD, an MIT Professor of Chemistry and Biology and a Howard Hughes Medical Institute Investigator. "If you could potentially inhibit that ...
case study solution Can Be Fun For Anyonecase study solution Can Be Fun For Anyone
The most important problem relating to safety and scientific feasibility of regular intake of MCPs is elevated from the nicely founded fact that the induction of collagen synthesis, generally assessed through the greater hydroxyproline concentrations, is usually connected to oxidative worry [28-thirty]. Also, MCPs of various origin are already proven to activate innate immune reaction of macrophages and neutrophils via Toll-like receptor 4, which leads to NADPH-oxidase (NOX4) activation and reactive oxygen species overproduction [31, 32 ...
TRANS METHYL O-BENZYL-L-4-HYDROXYPROLINE Global Market and Forecast Research : ReportsnReportsTRANS METHYL O-BENZYL-L-4-HYDROXYPROLINE Global Market and Forecast Research : ReportsnReports
[65 Pages Report] Check for Discount on TRANS METHYL O-BENZYL-L-4-HYDROXYPROLINE Global Market and Forecast Research report by ChemReport. DescriptionWe provide independent and unbiased information on manufacturers, prices, production...
Anaerobic Animals Discovered on Sea Floor - The Scientific ActivistAnaerobic Animals Discovered on Sea Floor - The Scientific Activist
As a clarification of the above, molecular oxygen, as I understand it, is necessary for the post-transcriptional hydroxylation of proline to hydroxyproline - ie the oxygen in the hydroxyproline does not come from water, but is added from an O2 molecule by an oxygenase enzyme.. The hydroxyprolines are critical for collagen strength. Thus in the complete absence of O2, animals bodies simply would not be able to hold together beyond a certain size (hence my first question about whether or not the small size gets around the problem).. The level of O2 needed is actually much lower than current atmospheric O2 in aerobic environments, and may be low enough that it could be found even in environments that would be considered to be hypoxic. But the post seemed to suggest that these animals lived in a completely anoxic environment - there is no O2 at all? If which case, how do these animals synthesize collagen?. ...
Dodeca-CLE Peptides as Suppressors of Plant Stem Cell Differentiation | ScienceDodeca-CLE Peptides as Suppressors of Plant Stem Cell Differentiation | Science
In plants and animals, small peptide ligands that signal in cell-cell communication have been suggested to be a crucial component of development. A bioassay of single-cell transdifferentation demonstrates that a dodecapeptide with two hydroxyproline residues is the functional product of genes from the CLE family, which includes CLAVATA3 in Arabidopsis. The dodecapeptide suppresses xylem cell development at a concentration of 10-11 M and promotes cell division. An application, corresponding to all 26 Arabidopsis CLE protein family members, of synthetic dodecapeptides reveals two counteracting signaling pathways involved in stem cell fate. ...
Anti-Hydroxyproline antibody (ab37067) | AbcamAnti-Hydroxyproline antibody (ab37067) | Abcam
Rabbit polyclonal Hydroxyproline antibody validated for WB, IHC. Referenced in 3 publications and 3 independent reviews. Immunogen corresponding to synthetic…
IMP: Integrative Multi-species PredictionIMP: Integrative Multi-species Prediction
The network for 4 hydroxyproline metabolic process in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order. ...
Official Glutafit L Glutathione Chitosan Hydroxyproline Dietary Supplement -- Travels with TimurOfficial Glutafit L Glutathione Chitosan Hydroxyproline Dietary Supplement -- Travels with Timur
Glutafit L Glutathione Chitosan Hydroxyproline Dietary Supplement Top Appetite Suppressant 2019 Robust Dietary Supplement Effects Choose A Good Quality Dietary Supplement Usp Natural Ways To Curb Your Appetite Glutafit L Glutathione Chitosan Hydroxyproline Dietary Supplement Best Reviews Diabetes Pills Used For Weight Loss Dr. Medicine To Reduce Appetite Best Otc Appetite Suppressant 2019 Travels with Timur. The reason why Glutafit they usually stay here except for L his Glutathione father and his two friends After Chitosan more than two Hydroxyproline years, the Glutafit L Glutathione Chitosan Hydroxyproline Dietary Supplement two have grown Dietary a Supplement lot stronger The young dragons of the dragon have reached a new stage. Eisai via AP That new understanding is why some major medical associations have come to see diet pills as intrinsic in the battle against obesity. This is the feeling of strength, this is the cooperation of the team, this is the feeling of being a member of the Storm ...
Hydroxyproline Excretion and Height Velocity in Adolescent Boys | Archives of Disease in ChildhoodHydroxyproline Excretion and Height Velocity in Adolescent Boys | Archives of Disease in Childhood
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Centers RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.. ...
Formulations comprising ceramides and/or pseudoceramides and (alpha-)bisabolol for combating skin damage - Patent applicationFormulations comprising ceramides and/or pseudoceramides and (alpha-)bisabolol for combating skin damage - Patent application
TABLE-US-00001 NAME OF RAW MATERIAL WEIGHT % (MANUFACTURER) INCI 1 2 3 4 5 6 7 8 9 10 Pseudoceramides Pseudoceramide 176 N-(1-dodecanoyl)-4- 0.1 0.2 0.1 hydroxy-L-proline 1- hexadecyl ester Pseudoceramide 391 N-(1-hexadecanoyl)-4- 0.2 0.1 0.1 0.1 0.2 0.5 hydroxy-L-proline 1- hexadecyl ester Ceramide PC104 (Pacific hydroxypropyl- 0.1 Corporation) bispalmitamide MEA Ceramide SL (Sino Lion) hydroxyethyl-palmityl- 0.1 oxyhydroxypropyl- palmitamide Aqua-Ceramide (Kao) cetyloxypropyl-glyceryl- 0.1 0.1 methoxypropyl- myristamide Ceramides Ceramide 2 (Sederma) ceramide 2 0.1 Ceramide III (Cosmoferm) ceramide 3 0.1 Bisabolol (Alpha-)Bisabolol, natural bisabolol 0.2 0.3 0.2 0.5 0.1 (Symrise) Dragosantol (Symrise) bisabolol 0.3 0.4 0.2 0.3 0.3 Fatty acids Linoleic Acid linoleic acid 0.1 0.2 Palmitic Acid palmitic acid 0.1 0.1 0.2 Stearic Acid stearic acid 0.1 Sterols Cholesterol (Croda) cholesterol 0.1 0.5 Tamasterol (Tama Biochemicals) phytosterol 0.2 Other ingredients Abil 350 (Degussa- dimethicone 0.5 ...
Triple-helix formation on ribosome-bound nascent chains of procollagen: deuterium-hydrogen exchange studies | PNASTriple-helix formation on ribosome-bound nascent chains of procollagen: deuterium-hydrogen exchange studies | PNAS
Polyribosomes containing nascent [3H]proline-labeled collagen chains were isolated from chick embryo fibroblasts in culture. These nascent chains were nearly completely hydroxylated, as indicated by the presence of [3H]hydroxyproline and high hydroxyproline/proline ratios. The polyribosomes were suspended in D2O at 15 degrees and the infrared spectrum was determined using a reference cell containing collagen-depleted polyribosomes in D2O, matched to equal RNA content. The amide I and amide II bands were observed. When the polyribosomes were heated in D2O at 44 degrees in the infrared cells, the N--D amide II absorbance at 1480 cm-1 increased markedly, indicating that H leads to D exchange had occurred. Collagen-depleted polyribosomes showed no such changes in absorbance at 1450-1480 cm-1 upon heating. Polyribosomes recovered from the infrared cells after treatment at 44 degrees and cooling still contained collagen, as indicated by their [3H]hydroxyproline content. These data indicate that ...
Hydroxyproline assay | Scientist SolutionsHydroxyproline assay | Scientist Solutions
Hello Kapil,. Thanks for your interesting questions.. Sorry for the delayed replay. I was swamped in my work for a while, needless to explain the pressure.. Answer to your 1st question: As we all know, speed vac or centrifugal evaporator works by reducing the pressure under vacuum so does the boiling point of a given solvent. The centrifugal force generated during this process will evaporate the solvent from top, thus it prevent loss or solute by solvent bumping (in other words, by violent boiling). During centrifugal evaporation of HCl from our sample, we all assume that there will be a small loss of hydroxy proline (HYP) but this will be a similar error if we treat all our samples in the same way. It is known that the loss of HYP on drying is ≤ 0.1% at 110 C and I am sure centrifugal evaporator with no heat (assuming we are not using heating option in the instrument) will not reach this temp.. In summary, you have to dry the HCl in the absence of heat in centrifugal evaporator. If you are ...
Direct current electrical stimulation of tendon healing in vitro - Alpha-Stim for AnimalsDirect current electrical stimulation of tendon healing in vitro - Alpha-Stim for Animals
The intrinsic capacity of tendons to heal in response to injury has recently been demonstrated by many investigators. Electrical stimulation is often assumed to augment regeneration of various tissues. Using newly developed methods of whole-tendon culture, the authors examined the effect of direct-current electricity on healing in vitro. Deep flexor tendons of rabbits were excised, transected, repaired, and grown in an acellular culture medium for seven, 14, 21, or 42 days. Tendons through which a continuous 7-microAmp current was passed at the repair site were compared with nonstimulated controls. The incorporation of (14C)proline and its conversion to (14C)hydroxyproline was measured at seven days. The mean (14C)proline and (14C)hydroxyproline activities were 91% and 255% greater, respectively, in the stimulated group. The activity was also higher in the stimulated group, by 42 days. Histologic sections showed that intrinsic tenoblastic repair may be enhanced with electrical stimulation in ...
Sandwalk: CollagenSandwalk: Collagen
The collagen triple helix is stabilized by interchain hydrogen bonds. The sequence of the protein in the helical region consists of multiple repeats of the form -Gly-X-Y-, where X is often proline and Y is often a modified proline called 4-hydroxyproline. The glycine residues are located along the central axis of the triple helix, where tight packing of the protein strands can accommodate no other residue. For each -Gly-X-Y- triplet, one hydrogen bond forms between the amide hydrogen atom of glycine in one chain and the carbonyl oxygen atom of residue X in an adjacent chain. Hydrogen bonds involving the hydroxyl group of hydroxyproline may also stabilize the collagen triple helix. Unlike the more common α helix, the collagen helix has no intrachain hydrogen bonds ...
Löfman, OweLöfman, Owe
Background. Bone mineral density (BMD) is used to follow gain or loss of bone mass but cannot detect changes within a short period of time. Biochemical markers of bone turnover may be of value for prediction of individual bone loss.. Methods. We studied the relation between common inexpensive markers of bone turnover (serum alkaline phosphatase (ALP), osteocalcin (OC), urinary hydroxyproline (OHPr), and calcium (Ca)), BMD, age, and menopause in a combined cross-sectional and longitudinal design comprising 429 pre- and postmenopausal randomly selected women aged 21-79 years (mean 50 years). A follow-up was initiated after 5 years (including 192 of these women), which focused on changes in bone mass and the ability of these four common markers of bone turnover (sampled at baseline) to predict future bone loss.. Results. A marked increase was observed for all markers at the beginning of menopause. During the postmenopausal period ALP and Ca decreased to near premenopausal levels, while OC and OHPr ...
Efficient synthesis of supported proline catalysts for asymmetric aldol reactions - Catalysis Science & Technology (RSC...Efficient synthesis of supported proline catalysts for asymmetric aldol reactions - Catalysis Science & Technology (RSC...
Proline has been grafted onto silica supports in a single step by reacting trans-4-hydroxy-l-proline with chloropropyl tethers, without the use of protecting groups for the proline amine and carboxylic acid functional groups. The resulting catalysts have been characterised to show that grafting is through re Catalysis on Chiral Surfaces: From Fundamental Aspects to Application
Anti-fibrosis treatment with prizaquantel reduced areas | Open-iAnti-fibrosis treatment with prizaquantel reduced areas | Open-i
Anti-fibrosis treatment with prizaquantel reduced areas of liver Sirius Red staining and liver hydroxyproline contents of mice 8 weeks post infection with Schis
Browse Products Containing: HYDROXYPROLINE || Skin Deep® Cosmetics Database | EWGBrowse Products Containing: HYDROXYPROLINE || Skin Deep® Cosmetics Database | EWG
Beyond providing Skin Deep® as an educational tool for consumers, EWG offers its EWG VERIFIED™ mark as a quick and easily identifiable way of conveying personal care products that meet EWGs strict health criteria. Before a company can use EWG VERIFIEDTM on such products, the company must show that it fully discloses the products ingredients on their labels or packaging, they do not contain EWG ingredients of concern, and are made with good manufacturing practices, among other criteria. Note that EWG receives licensing fees from all EWG VERIFIED member companies that help to support the important work we do. Learn more , Legal Disclaimer ...
Arginine / HydroxyprolineArginine / Hydroxyproline
Open Beauty Facts est développé par une association à but non lucratif indépendante de lindustrie. Open Food Facts est fait pour tous, par tous, et est financé par tous. Vous pouvez soutenir notre travail en donnant à Open Beauty Facts et aussi en utilisant le moteur de recherche Lilo ...
Soluble Collagen (Explained + Products)Soluble Collagen (Explained + Products)
Soluble Collagen refers to the big, natural collagen molecules mostly extracted from fish or bovine skin. Spotting collagen on the ingredient...
SMART: P4Hc domain annotationSMART: P4Hc domain annotation
Prolyl 4-hydroxylase (EC 1.14.11.2) catalyzes the formation of4-hydroxyproline in collagens by the hydroxylation of proline residues inX-Pro-Gly sequences. The reaction requires Fe2+, 2-oxoglutarate, O2, andascorbate and involves an oxidative decarboxylation of 2-oxoglutarate.Ascorbate is not consumed during most catalytic cycles, but the enzymealso catalyzes decarboxylation of 2-oxoglutarate without subsequenthydroxylation, and ascorbate is required as a specific alternative oxygenacceptor in such uncoupled reaction cycles. A number of compounds inhibitprolyl 4-hydroxylase competitively with respect to some of itscosubstrates or the peptide substrate, and recently many suicideinactivators have also been described. Such inhibitors and inactivatorsare of considerable interest, because the prolyl 4-hydroxylase reactionwould seem a particularly suitable target for chemical regulation of theexcessive collagen formation found in patients with various fibroticdiseases. The active prolyl 4-hydroxylase ...
Hydrolyzed Collagen Side EffectsHydrolyzed Collagen Side Effects
Gelatin is a form of hydrolyzed collagen which brings a ready supply of four essential amino acids: glycine, proline, hydroxyproline, and glutamic acid. Nails and skin benefit from these amino acids.
Resistance of fibrogenic responses to glucocorticoid and 2-methoxyestradiol in bleomycin-induced lung fibrosis in mice. -...Resistance of fibrogenic responses to glucocorticoid and 2-methoxyestradiol in bleomycin-induced lung fibrosis in mice. -...
Bleomycin-induced lung fibrosis in mice reproduces some key features of pulmonary fibrosis in humans including alveolar inflammation, myofibroblast proliferation, and collagen deposition. Glucocorticoids have been used as first-line therapy for the treatment of lung fibrosis, although their clinical efficacy is equivocal. We examined the effect of the glucocorticoid, methylprednisolone (MP), and the estrogen metabolite, 2-methoxyestradiol (2MEO) on bleomycin-induced bronchoalveolar inflammation, fibrosis, and changes in lung function. The characterization of the time-course of the bleomycin-induced fibrosis indicated that lung dry mass and hydroxyproline content showed less variance than histopathological assessment of fibrosis. The bleomycin-induced increases in bronchoalveolar lavage (BAL) fluid cell number and protein levels were not significantly influenced by treatment with either MP (1 mg.(kg body mass)(-1).day(-1), i.p.) or 2MEO (50 mg.(kg body mass)(-1).day(-1), i.p.). Lung fibrosis, ...
Cervical collagen is reduced in non-pregnant women with a history of cervical insufficiency and a short cervix - Forskning -...Cervical collagen is reduced in non-pregnant women with a history of cervical insufficiency and a short cervix - Forskning -...
INTRODUCTION: Preterm cervical shortening and cervical insufficiency may be caused by a constitutional weakness of the cervix. The aim of this study was to assess the cervical collagen concentration in non-pregnant women with a history of cervical insufficiency or of a short cervix in the second trimester of pregnancy.. MATERIAL AND METHODS: In this case-control study we included non-pregnant women one year or more after pregnancy: 55 controls with a history of normal delivery; 27 women with a history of cervical insufficiency; and 10 women with a history of a short cervix (,5th percentile) and 10 women with a history of a long cervix (,95th percentile) at gestational weeks 18-20. We obtained biopsies (3 × 3-4 mm) from the ectocervix and determined the collagen concentration by measuring the hydroxyproline concentration.. RESULTS: Women with cervical insufficiency had lower collagen concentrations (63.5 ± 5.1%; mean ± SD) compared with controls (68.2 ± 5.4%; p = 0.0004); area under the ROC ...
Acervo Digital: Early rather than delayed administration of lisinopril protects the heart after myocardial infarction in ratsAcervo Digital: Early rather than delayed administration of lisinopril protects the heart after myocardial infarction in rats
Background: ACE inhibitors have shown beneficial results in several studies after myocardial infarction (MI). However, these studies have shown conflicting results about the ideal starting time of the ACE inhibitors administration after MI and the importance of infarct size.Objectives: This study was designed to assess the long-term effects of lisinopril on mortality, cardiac function, and ventricular fibrosis after MI, in rats.Methods: Lisinopril (20 mg/kg/day) was given on day 1 or 21 days after coronary occlusion in small or large infarctions.Results: the mortality rate was reduced by 39% in early treatment and 30% in delayed treatment in comparison to the untreated rats. Early treatment reduced cardiac dysfunction in small MIs; however, delayed treatment did not. No statistical difference was observed among the groups for large MIs. No statistical difference was observed among the groups with large or small MIs on myocardial hydroxyproline concentration.Conclusions: Both early and delayed ...
Toll-like receptor 4 promotes fibrosis in bleomycin-induced lung injury in mice | GMR | Genetics and Molecular Research | The...Toll-like receptor 4 promotes fibrosis in bleomycin-induced lung injury in mice | GMR | Genetics and Molecular Research | The...
The specific role of Toll-like receptor 4 (TLR4) in bleomycin-induced lung fibrosis of mice, a model of human idiopathic pulmonary fibrosis, has not been characterized. We injected bleomycin intratracheally into TLR4 knockout (TLR4-/-) and wild-type (WT) mice. Twenty-one days after injection, mice were sacrificed and their lungs were harvested for pathological, hydroxyproline, mRNA expression, and collagen I analyses. Body weight changes and mortality were observed.
SMART: Pfam domain CollagenSMART: Pfam domain Collagen
Members of this family belong to the collagen superfamily [ (PUBMED:8240831) ]. Collagens are generally extracellular structural proteins involved in formation of connective tissue structure. The sequence is predominantly repeats of the G-X-Y and the polypeptide chains form a triple helix. The first position of the repeat is glycine, the second and third positions can be any residue but are frequently proline and hydroxyproline. Collagens are post-translationally modified by proline hydroxylase to form the hydroxyproline residues. Defective hydroxylation is the cause of scurvy. Some members of the collagen superfamily are not involved in connective tissue structure but share the same triple helical structure.. ...
Tribbles homologue 3 stimulates canonical TGF-β signalling to regulate fibroblast activation and tissue fibrosis | Annals of...Tribbles homologue 3 stimulates canonical TGF-β signalling to regulate fibroblast activation and tissue fibrosis | Annals of...
Results TRB3 expression was increased in fibroblasts of patients with SSc and in murine models of SSc in a transforming growth factor-β (TGF-β)/Smad-dependent manner. Overexpression of TRB3 stimulated canonical TGF-β signalling and induced an activated phenotype in resting fibroblasts. In contrast, knockdown of TRB3 reduced the profibrotic effects of TGF-β and decreased the collagen synthesis. Moreover, siRNA-mediated knockdown of TRB3 exerted potent antifibrotic effects and ameliorated bleomycin as well as constitutively active TGF-β receptor I-induced fibrosis with reduced dermal thickening, decreased hydroxyproline content and impaired myofibroblast differentiation. ...
FRI0525 Poly(ADP-RIBOSE) Polymerase-1 (PARP-1) Suppresses the Profibrotic Effects of Transforming Growth Factor-β in Systemic...FRI0525 Poly(ADP-RIBOSE) Polymerase-1 (PARP-1) Suppresses the Profibrotic Effects of Transforming Growth Factor-β in Systemic...
Results Decreased expression of PARP1 was detected by immunohistochemistry in skin sections of SSc patients, particularly in fibroblasts. Inhibition of PARylation by 3AB augmented the stimulatory effects of TGFβ on fibroblasts in vitro. PARP1 inhibition increased Smad dependent transcription in reporter assays and promoted the transcription of TGFβ/Smad target genes. Treatment with 3AB also stimulated the collagen release and fostered the expression of contractile proteins with increased expression of α-smooth muscle actin (α-SMA) and enhanced formation of stress fiber formation compared to fibroblasts stimulated with TGFβ alone. Inhibition of PARylation also exacerbated experimental fibrosis in vivo. Treatment with 3AB induced a more severe fibrotic response to bleomycin with increased dermal thickening by up to 103% (p,0.0001), hydroxyproline contents and myofibroblast counts compared to control mice (p,0.0001 and p=0.0059). Inhibition of PARylation also strongly exacerbated fibrosis in ...
You Can Boost Your Skins Collagen Levels Without Using Animal-Derived Ingredients - CLEO MalaysiaYou Can Boost Your Skin's Collagen Levels Without Using Animal-Derived Ingredients - CLEO Malaysia
Keeping your skins collagen levels in check is so important and we cant say it enough! Read on to get some beauty tips and know more about how Payot Roselift Collagène range can help boost collagen naturally.
Prolyl 4-hydroxylase subunit alpha-3Prolyl 4-hydroxylase subunit alpha-3
This gene encodes a component of prolyl 4-hydroxylase, a key enzyme in collagen synthesis composed of two identical alpha subunits and two beta subunits. The encoded protein is one of several different types of alpha subunits and provides the major part of the catalytic site of the active enzyme. In collagen and related proteins, prolyl 4-hydroxylase catalyzes the formation of 4-hydroxyproline that is essential to the proper three-dimensional folding of newly synthesized procollagen chains. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014 ...
Absolute Face & Body - Collagen - Winter Springs, FLAbsolute Face & Body - Collagen - Winter Springs, FL
The protein composition of Collagen Type I & III consist of nineteen amino acids responsible for growth and maintenance of the body with unusually high percentages of glycine, proline, hydroxyproline, all of which are found in the skin and muscle. This is what make Collagen M.D. Advanced Connective Tissue Formula effective in those areas. ...
What is Collagen?What is Collagen?
Collagen is a protein made up of amino-acids, which are in turn built of carbon, oxygen and hydrogen. Collagen contains specific amino acids - Glycine, Proline, Hydroxyproline and Arginine.
A fibrotic trio | Science SignalingA fibrotic trio | Science Signaling
Although the lung can regenerate after injury, repeated injury results in fibrosis, which compromises respiratory function. Cao et al. injected damaging chemicals into the tracheas of mice to investigate how fibrosis due to repetitive injury occurred. Mice receiving a single injection recovered blood oxygen concentration and exhibited re-epithelialization by type 1 alveolar cells and proliferation of the surfactant-producing type 2 alveolar epithelial cells. However, mice receiving repeated injections did not and, instead, had the sustained presence of protein markers of fibrosis (α-smooth muscle actin, collagen I, and hydroxyproline). Examination of Notch signaling, a regulator of lung fibroblasts, using transgenic Notch reporter mice revealed that Notch activation occurred in perivascular fibroblasts after repetitive injury. Repetitive lung injury resulted in an increase in the abundance of the Notch ligand Jagged1 (Jag1) in the pulmonary capillary endothelial cells (PCECs), which function ...
collagen effective way to eliminate dark circles | ZHONG WEI Horticultural Products Company,(TOP QUALITY)Plant Seeds,Vegetables...collagen effective way to eliminate dark circles | ZHONG WEI Horticultural Products Company,(TOP QUALITY)Plant Seeds,Vegetables...
This product is rich in 18 kinds of amino acids human body required, including hydroxyproline, glycine, proline, which serves as function like protecting skins but can not be synthesized by our
antiarrhythmic peptide - AAP Summary Report | CureHunterantiarrhythmic peptide - AAP Summary Report | CureHunter
antiarrhythmic peptide: atrial peptide from bovine atria; hexapeptide composed of hydroxyproline(1), proline(1), glycine(3) & alanine(1); both N-terminal & carboxy-terminal residues are glycine
Brighten skin and increase collagen levels | fromrusttoroadtripBrighten skin and increase collagen levels | fromrusttoroadtrip
Alpha Visage affects Face Wash Clean Face. I presume I need to find multitudes who have same interest in Alpha Visage. Each company has a different Alpha Visage scale and for that matter, a different way of Alpha Visage. Its the conclusion: There is very a bit implausible with what I am telling yo
SYIS AMPULKY PURE COLLAGEN 100% 10x3MLSYIS AMPULKY PURE COLLAGEN 100% 10x3ML
|p||strong|SYIS AMPULKY PURE COLLAGEN 100% 10x3ML|/strong||/p| |p|Ampulka Collagen Pure 100% obsahuje |strong|rozpustný kolagén - soluble collagen|/strong| – ktorý zadržiava vodu v pokožke a chráni ju pred vznikom vr&aac
Collagen Assay | Sircol™ | Biocolor | Biocolor.co.ukCollagen Assay | Sircol™ | Biocolor | Biocolor.co.uk
A colorimetric, soluble collagen assay for the analysis of acid and pepsin-soluble collagens produced in situ or during in-vitro cell culture.
Preventive effect of malotilate on carbon tetrachloride-induced liver damage and collagen accumulation in the rat | Biochemical...Preventive effect of malotilate on carbon tetrachloride-induced liver damage and collagen accumulation in the rat | Biochemical...
Malotilate is a new drug suggested for use in chronic liver diseases. It is shown here to prevent liver damage caused by CCl4. The concomitant administration of malotilate with CCl4 significantly decreased hydroxyproline accumulation in the liver, liver prolyl 4-hydroxylase and liver and serum galactosylhydroxylysyl glucosyltransferase activities. However, it had no effect on the daily urinary hydroxyproline excretion or the hydroxyproline content of the skin, liver or lungs in normal young growing rats. It also had no specific inhibitory effect on hydroxyproline synthesis or secretion in fibroblast cultures, and did not affect the amount of procollagen-alpha 1(I)-specific mRNAs in these cultures. Thus it seems to have no direct inhibitory effect on collagen metabolism. In addition to inhibition of liver collagen accumulation, malotilate was also able to prevent the development of morphological changes in the liver such as focal necrosis, fatty infiltration and inflammatory changes. It also ...
Tamoxifen reduces bone turnover and prevents lumbar spine and proximal femoral bone loss in early postmenopausal women | Garvan...Tamoxifen reduces bone turnover and prevents lumbar spine and proximal femoral bone loss in early postmenopausal women | Garvan...
Although widely used for its anti-estrogen properties tamoxifen has estrogen like effects on a number of tissues including bone and liver. Previous studies suggest a preservation of lumbar spine density in postmenopausal women but the effect on the hip had not been addressed. To determine whether tamoxifen prevents bone loss in the early postmenopausal period bone mineral density at the lumbar spine and femoral neck was measured using dual energy X-ray absorptiometry at presentation and 6 monthly thereafter for 1 year in a prospective controlled study. Also indices of bone turnover, serum osteocalcin and urinary hydroxyproline excretion, were assessed. Fifteen early postmenopausal women with Stage I or II breast cancer treated with tamoxifen and 21 normal postmenopausal women were studied. Sex hormone binding globulin and antithrombin III levels in serum were also measured as indices of the hepatic estrogenic activity. Tamoxifen (20 mg daily) prevented bone loss at the femoral neck and lumbar spine.
Quantitative Metabolome Profiling of Colon and Stomach Cancer Microenvironment by Capillary Electrophoresis Time-of-Flight Mass...Quantitative Metabolome Profiling of Colon and Stomach Cancer Microenvironment by Capillary Electrophoresis Time-of-Flight Mass...
One obvious question raised is the origin of these amino acids. Under limited blood supply, two main sources of amino acids can be conceived: one is the degradation of extracellular matrix particularly by matrix metalloproteinases and the other is the autophagic degradation of preexisting intracellular proteins. In this perspective, it is notable that hydroxyproline concentration was significantly higher in tumor tissues than in their normal counterparts (P = 0.0005 in colon and P = 0.0025 in stomach tissues). Hydroxyproline is abundant in collagen and is posttranslationally produced from proline, which suggests that the higher concentration of hydroxyproline in tumor tissues is indicative of excess degradation of collagen ( 35). Autophagy is another possible source of amino acids, as it is well-documented that autophagy liberates and thereby increases the free amino acid pools ( 36, 37). We also have found recently that autophagy seems essential for colon cancer cell survival ( 38) and is ...
IJMS | Free Full-Text | Fasudil, a Rho-Kinase Inhibitor, Attenuates Bleomycin-Induced Pulmonary Fibrosis in MiceIJMS | Free Full-Text | Fasudil, a Rho-Kinase Inhibitor, Attenuates Bleomycin-Induced Pulmonary Fibrosis in Mice
The mechanisms underlying the pathogenesis of idiopathic pulmonary fibrosis (IPF) involve multiple pathways, such as inflammation, epithelial mesenchymal transition, coagulation, oxidative stress, and developmental processes. The small GTPase, RhoA, and its target protein, Rho-kinase (ROCK), may interact with other signaling pathways known to contribute to pulmonary fibrosis. This study aimed to determine the beneficial effects and mechanisms of fasudil, a selective ROCK inhibitor, on bleomycin-induced pulmonary fibrosis in mice. Our results showed that the Aschcroft score and hydroxyproline content of the bleomycin-treated mouse lung decreased in response to fasudil treatment. The number of infiltrated inflammatory cells in the bronchoalveolar lavage fluid (BALF) was attenuated by fasudil. In addition, fasudil reduced the production of transforming growth factor-β1 (TGF-β1), connective tissue growth factor (CTGF), alpha-smooth muscle actin (α-SMA), and plasminogen activator inhibitor-1 (PAI-1)
A collagen-like amino acid sequence in a polypeptide chain of human C1q (a subcomponent of the first component of complement) |...A collagen-like amino acid sequence in a polypeptide chain of human C1q (a subcomponent of the first component of complement) |...
1. A partial amino acid sequence of 95 residues of the 191 residues in the oxidized A chain of human subcomponent C1q was determined. The partial nature of the sequence is because one overlapping peptide is missing in the proposed sequence, also the proof of some of the overlapping peptides depends partly on their amino acid composition and not on their complete sequence. 2. This region of the A chain contained a repeating sequence of glycine-X-Y (where X is often proline and Y is often hydroxyproline) for 78 residues. 3. The five hydroxylysine residues and the five hydroxyproline residues present in the oxidized A chain were all in these 78 residues and only in the Y position of the repeating sequence. 4. Prolonged collagenase digestion of the oxidized A chain yielded a large, apparently C-terminal, peptide which contained most of the non-collagenous sequences present in the chain. 5. It is concluded that there is a collagen-like region in the A chain of subcomponent C1q which constitutes most ...
Polyphenolic Substance of Mytilus edulis: Novel Adhesive Containing L-Dopa and Hydroxyproline | SciencePolyphenolic Substance of Mytilus edulis: Novel Adhesive Containing L-Dopa and Hydroxyproline | Science
The fouling marine mussel Mytilus edulis attaches itself to various substrates by spinning byssal threads, the adhesive discs of which are rich in the amino acid 3,4-dihydroxyphenylalanine (dopa). An acid-soluble protein was extracted and purified from the phenol gland located in the byssus-secreting foot of the animal. This protein is highly basic and contains large amounts of lysine, dopa, and 3- and 4-hydroxyproline. The composition of this protein and its sticky tendencies in vitro strongly suggest that it contributes to byssal adhesion.. ...
Differences in Hepatic Fibrosis in Icr, C3H, and C57BL/6 Mice Infected with Schistosoma Mansoni* | The American Journal of...Differences in Hepatic Fibrosis in Icr, C3H, and C57BL/6 Mice Infected with Schistosoma Mansoni* | The American Journal of...
Abstract The collagen content of the liver, measured as hepatic hydroxyproline, was examined for a period of up to 52 weeks following Schistosoma mansoni infection. Hepatic fibrosis was much more marked in S. mansoni-infected mice of an outbred ICR strain than in C57BL/6J mice, while C3H/HeN mice occupied an intermediate position. The marked difference in hepatic fibrosis in ICR and C57BL/6J mice correlated with more rapid in vitro synthesis of collagen by the livers of infected ICR mice. Strains of mice exhibiting high and low levels of fibrosis provide an excellent tool for examining mechanisms of murine schistosomal hepatic fibrosis and its genetic regulation.
Effects of Ma-Xing-Shi-Gan-Tang on Bleomycin- Induced Lung Fibrosis in Rats | NCHU Institution RepositoryEffects of Ma-Xing-Shi-Gan-Tang on Bleomycin- Induced Lung Fibrosis in Rats | NCHU Institution Repository
In this study, after doses of 1 g/kg/day of the traditional Chinese formula Ma-Xing-Shi-Gan-Tang (MXSGT), significant reversal of pneumatocysts was achieved in Spague-Dawley rats with bleomycin-induced lung fibrosis. We found that MXSGT can improve the damaged condition of general cellular membranes. Greatly increased levels of lung NO were found in the bleomycin-induced group, which were then significantly reduced by MXSGT. MXSGT drastically prevented depletion of superoxide dismutase (SOD) and reduced the myeloperoxidase (MPO) activities and malondialdehyde (MDA) levels in lung tissue of rats treated with bleomycin. On the basis of the results presented in this paper, MXSGT prevents bleomycin-induced lung fibrosis, and the mechanism may be due to the inhibitory effect on nitric oxide generation in the bleomycin-induced lung-fibrosis model of rats ...
AN EXPERIMENTAL MODEL OF HEPATIC FIBROSIS INDUCED BY THE ADMINISTRATIO by Jeannee Karen Yermakoff"AN EXPERIMENTAL MODEL OF HEPATIC FIBROSIS INDUCED BY THE ADMINISTRATIO" by Jeannee Karen Yermakoff
Dibutyltin dichloride (DBT}, one of a series of dialkyltin derivatives used industrially as polyvinylchloride stabilizers and urethane catalysts, was investigated for its ability to induce liver fibrosis in rats. Collagen, the predominant protein in fibrotic tissue, is synthesized in a series of sequential steps consisting of assembly of a proline-rich and lysine-rich polypeptide precursor of collagen, enzymatic hydroxylation of some of the prolyl and lysyl residues, and glycosylation of some of · the hydroxylysyl residues. Since prolyl residues are not hydroxylated before they are in peptide-bound form, the conversion of isotopically labeled proline to hydroxyproline by prolyl hydroxylase was taken as one parameter reflecting the rate of collagen formation. In vitro collagen synthesis was determined by incubation of liver biopsies with labeled proline, after which incorporation of label into collagenase digestible protein is compared to incorporation into collagenase- resistant protein. Hydroxyproline
GW24-e2192 NK-1 Receptor-mediated Renal Injury during DOCA-salt Hypertension | HeartGW24-e2192 NK-1 Receptor-mediated Renal Injury during DOCA-salt Hypertension | Heart
Results DOCA-salt treatment for 5 weeks increased mean arterial pressure (MAP) determined by the telemetry system (144 ± 3 vs. 108 ± 4 mmHg, P , 0.01) and renal hypertrophy (116.3 ± 2.7 vs. 75.7 ± 1.4 mg/10 g of BW, P , 0.01) compared with sham mice. We also found that urinary 8-isoprostane and albumin excretion were increased in DOCA-salt mice compared with sham mice (1.76 ± 0.16 vs. 0.49 ± 0.10 ng/24 h; 41.1 ± 3.5 vs. 5.8 ± 0.6 μg/24 h, P , 0.05). Periodic acid-Schiff and Massons trichrome staining showed that DOCA-salt treatment caused obvious glomerulosclerosis and tubulointerstitial injury in the renal cortex (0.62 ± 0.06 vs. 0.08 ± 0.01; 3.00 ± 0.30 vs. 0.21 ± 0.10, P , 0.05), and tubulointerstitial fibrosis compared with the sham mice. Consistent with the results, renal collagen level determined using hydroxyproline assay was higher in DOCA-salt treated mice compared with the sham mice (26.8 ± 2.4 vs. 12.2 ± 1.3 μg/mg dry tissue, P , 0.05). In addition, F4/80-staining ...
Cardiac Arrhythmogenic Remodeling in a Rat Model of Long-Term Intensive Exercise TrainingClinical Perspective | CirculationCardiac Arrhythmogenic Remodeling in a Rat Model of Long-Term Intensive Exercise TrainingClinical Perspective | Circulation
Perhaps our most noteworthy finding is the demonstration of myocardial fibrosis after long-term, intensive exercise training. RV fibrosis was documented by collagen quantification in histological sections and analysis of hydroxyproline content. These observations were functionally paralleled by the development of RV diastolic dysfunction, with impaired relaxation potentially related to fibrotic infiltration. Moreover, we noted an increase in mRNA and protein expression of a series of fibrotic markers in the RV and in both atria. TGF-β1 expression was increased in the RA, LA, and RV after 16 weeks of intensive exercise. TGF-β1 is a potent stimulator of collagen-producing cardiac myofibroblasts22 and leads to fibrosis development. Experimental studies have reported that both genetic ablation of TGF-β1 in mice23 and treatment with anti-TGF-β1 antibodies24 inhibit fibrosis development, indicating that TGF-β1 plays a major role in collagen turnover. We also noted enhanced expression of other ...
The cell. 2. Extracellular matrix. Components: proteins. Atlas of plant and animal histology.The cell. 2. Extracellular matrix. Components: proteins. Atlas of plant and animal histology.
Moreover, there are some collagen molecules containing sequences of hydrophobic amino acids inserted in the plasma membrane. For example, type XIII and XVII collagens. Collagen type XVII is part of the molecular structure of hemidesmosomes. No matter the type, collagen is synthesized inside the cell as a precursor: the pro-collagen molecule. First, alpha chains are synthesized in the endoplasmic reticulum, where proline becomes hydroxyproline by hydroxylation. Proline and hydroxyproline may be up to 20 % of the alpha chain. GLycosylation (type O-glycosylation) of alpha chains also occurs in the reticulum. At this point, three alpha chains join together by hydrogen bonds to finally form the pro-collagen molecule. Disulfide bridges are also formed between the alpha chains. Pro-collagen molecules are recognized and linked by transmembrane receptors and packaged in COPII coated vesicles. Typical COPII vesicles are 60 to 90 nm in diameter, but COPII vesicles transporting pro-collagen are 500 nm in ...
Hydroxyproline in wheat endosperm and wheat seedling rootsHydroxyproline in wheat endosperm and wheat seedling roots
Rights: This volume was digitized and made accessible online due to deterioration of the original print copy. If you are the author of this work and would like to have online access removed, please contact the Library Administration Office, 785-532-7400, [email protected] ...
Browsing Botany and Plant Science (Scholarly Articles) by Subject Leucine-rich repeatBrowsing Botany and Plant Science (Scholarly Articles) by Subject "Leucine-rich repeat"
Extensins (EXTs) are a family of plant cell wall hydroxyproline-rich glycoproteins (HRGPs) that are implicated to play important roles in plant growth, development, and defense. Structurally, EXTs are characterized by the ...
Lab Series Glucosamine & Marine Collagen - Myo-BandLab Series Glucosamine & Marine Collagen - Myo-Band
Collagen is a protein made up of amino-acids: glycine, proline, hydroxyproline, and arginine. Ligaments and tendons are other types of connective tissue that attach two bones and muscles, holding them together. These tissues - bones, ligaments, tendons, and the skeletal muscles are made up of proteins, where collagen is one of the main proteins involved. Collagen has also been linked to healthier skin and is used widely not just in supplements but in anti-ageing cosmetics and whilst these products work externally on your body, our LAB Series Glucosamine & Marine Collagen helps aid from the inside out. ...
Benefits And Usage Of Powdered Collagen - Disability In CyprusBenefits And Usage Of Powdered Collagen - Disability In Cyprus
Collagen is a protein found in skin and connective tissues of the body. Responsible for keeping skin smooth and bouncy, collagen sums up to 70% of the total protein found in skin and more than a quarter percent of total protein in the complete body.. Made up of proline, glycine and hydroxyproline and tons of few other amino acids, Collagen fits suitably to serve a various purpose and is very beneficial for human body. Intake of powdered collagen helps to fight skin aging by improving its elasticity, which normally at certain age gets turned to wrinkle. You also have an option of buying these proteins online at belivestore (Official Website: https://belivestore.com/) as per your choice at affordable rates. ...
Protective Effect of Onion Extract on Bleomycin-Induced Cytotoxicity and Genotoxicity in Human Lymphocytes. | Sigma-AldrichProtective Effect of Onion Extract on Bleomycin-Induced Cytotoxicity and Genotoxicity in Human Lymphocytes. | Sigma-Aldrich
Sigma-Aldrich offers abstracts and full-text articles by [Yoon Hee Cho, Joong Won Lee, Hae Dong Woo, Sunyeong Lee, Yang Jee Kim, Younghyun Lee, Sangah Shin, Hyojee Joung, Hai Won Chung].
The smart Trick of antioxidant foods for cancer That Nobody is DiscussingThe smart Trick of antioxidant foods for cancer That Nobody is Discussing
Ascorbic acid or "vitamin C" is really a monosaccharide oxidation-reduction (redox) catalyst found in each animals and crops. As among the list of enzymes needed to make ascorbic acid has long been missing by mutation in the course of primate evolution, human beings have to acquire it within the diet; it is actually consequently a vitamin.[104] Most other animals have the ability to generate this compound inside their bodies and do not involve it inside their diets.[one hundred and five] Ascorbic acid is required to the conversion with the procollagen to collagen by oxidizing proline residues to hydroxyproline. In other cells, its managed in its lowered variety by reaction with glutathione, which is usually catalysed by protein disulfide isomerase and glutaredoxins ...
vital proteins | Sound Shore Moms of Westchestervital proteins | Sound Shore Moms of Westchester
Vital Proteins Collagen contains 18 amino-acids, including 8 out of 9 essential amino-acids. It is characterized by the predominance of glycine, proline and hydroxyproline, which represent about 50% of the total amino-acid content. Glycine and proline concentration is ...
SAUSA300 1711 - AureoWikiSAUSA300 1711 - AureoWiki
Amino Acids and DerivativesProline and 4-hydroxyprolineProline, 4-hydroxyproline uptake and utilization Proline dehydrogenase (EC 1.5.99.8) (Proline oxidase) ...
What a fabulous treat! | QCommunityWhat a fabulous treat! | QCommunity
Without giving too much away the collection is all about wrinkle-filling, skin-plumping collagen, and the latest in soluble collagen technology from Active Marine ingredients to treat the skin on the surface and deeper down. Using a brand new triple-strength collagen cocktail of Pro-collagen, Atelcollagen and Marine Soluble collagen, this kit will have your skin looking visibly younger for spring and summer, with a reduction in the appearance of lines and wrinkles and a wonderfully smooth, moisturised texture. It gave me real insight to experience how trained therapists apply the serums and creams to get the best out of them. I was in the expert hands of Samantha Lees (Gatineau Trainer & SkinCare Therapist similar to Michaela Taylor), who talked me though my facial and exactly how to apply it. Lying down and relaxed I could feel my skin drinking in each application - beautiful textures and instant absorption. I absolutely loved the new Collagen Expert Targeted Wrinkle Corrector, which delivers ...
Soluble CollagenSoluble Collagen
In the ingredient descriptions: Good means that I like to see this in a products list of ingredients. Okay means this product appears safe for a curly person like me to use. Caution means that this ingredient may not be good in some hair care products, or for some people. Avoid means this ingredient may hurt your hair. If you see this ingredient in a hair product, its best to put it down and walk away ...
Le Mieuxs StemCell EGFLe Mieuxs StemCell EGF
StemCell EGF are ampoules that work to fight against collagen breakdown in the skin while boosting skins suppleness and radiance.
Non-proteinogenic amino acidsNon-proteinogenic amino acids
1-Pyrroline-5-carboxylate dehydrogenase1-Pyrroline-5-carboxylate dehydrogenase
Pyrroline-5-carboxylate reductasePyrroline-5-carboxylate reductase
CitrullineCitrulline
OrnithineOrnithine
gamma-Aminobutyric acidgamma-Aminobutyric acid
Aldehyde dehydrogenase 4 family, member A1Aldehyde dehydrogenase 4 family, member A1
TULP1TULP1
Arabinogalactan proteinArabinogalactan protein
GelatinGelatin
Mannan-binding lectinMannan-binding lectin
AlkanolamineAlkanolamine
Collagen helixCollagen helix
TCEB1TCEB1
Hypoxia-inducible factorsHypoxia-inducible factors
Pagets disease of bonePaget's disease of bone
CUL2CUL2
HIF1AHIF1A
TCEB2TCEB2
Kininogen 1Kininogen 1
Eyespot (wheat)Eyespot (wheat)
X-Pro dipeptidaseX-Pro dipeptidase
CollagenCollagen
Von Hippel-Lindau tumor suppressorVon Hippel-Lindau tumor suppressor
CollagenCollagen
HydroxylationHydroxylation
Roswell Park Memorial Institute mediumRoswell Park Memorial Institute medium
EGLN2EGLN2
SysteminSystemin
1-pirolin-5-karboksilat dehidrogenaza - Википедија, слободна енциклопедија1-pirolin-5-karboksilat dehidrogenaza - Википедија, слободна енциклопедија
AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and Processes
HydroxyprolineCollagenProlineHydroxylysineProcollagen-Proline DioxygenasePulmonary FibrosisBleomycinOsteitis DeformansUronic AcidsLiver Cirrhosis, ExperimentalPlant Somatic Embryogenesis TechniquesMicrobial CollagenaseAscorbic Acid DeficiencyAmino AcidsDesmosineProcollagenOxalatesPeplomycinCollagen Type IIIHydroxylationGlycolatesWound HealingCarbon TetrachlorideCollagen Type IGalactansBone and BonesFibrosisBone ResorptionLungAlkaline PhosphataseAnastomosis, SurgicalAmino Acid Metabolism, Inborn ErrorsGlycosaminoglycansLiver CirrhosisPhosphorusArabinoseDisease Models, AnimalProline OxidaseMusaRats, WistarHyperoxaluriaAntibodiesAntibody SpecificityAntibodies, MonoclonalRabbitsAntibodies, ViralAntibodies, BacterialCentrifugationTransition TemperatureAntibodies, ArchaealAntigens, ArchaealSolvents
Anti-Hydroxyproline antibody (ab37067) | AbcamAnti-Hydroxyproline antibody (ab37067) | Abcam
Biology-Online • View topic - hydroxyprolineBiology-Online • View topic - hydroxyproline
TRANS METHYL O-BENZYL-L-4-HYDROXYPROLINE Global Market and Forecast Research : ReportsnReportsTRANS METHYL O-BENZYL-L-4-HYDROXYPROLINE Global Market and Forecast Research : ReportsnReports
Network Portal - Function 4-hydroxyproline metabolic processNetwork Portal - Function 4-hydroxyproline metabolic process
Serial spot hydroxyproline/creatinine ratios in metastatic prostatic cancer<...Serial spot hydroxyproline/creatinine ratios in metastatic prostatic cancer<...
The synthetic hydroxyproline-containing collagen analogue (Gly-Pro-Hyp) 10 promotes enzymatic activity of...The synthetic hydroxyproline-containing collagen analogue (Gly-Pro-Hyp) 10 promotes enzymatic activity of...
I think I now know why STURP chemist Raymond Rogers detected hydroxyproline in the blood on the Shroud - and its to do with...I think I now know why STURP chemist Raymond Rogers detected hydroxyproline in the blood on the Shroud - and it's to do with...
Plus itPlus it
Pagets Disease of Bone Treated with a Five Day Course of Oral Tiludronate - Reginster Jean-YvesPaget's Disease of Bone Treated with a Five Day Course of Oral Tiludronate - Reginster Jean-Yves
Hydroxyproline - WikipediaHydroxyproline - Wikipedia
4-hydroxyproline epimerase - Wikipedia4-hydroxyproline epimerase - Wikipedia
Browse Products Containing: HYDROXYPROLINE || Skin Deep® Cosmetics Database | EWGBrowse Products Containing: HYDROXYPROLINE || Skin Deep® Cosmetics Database | EWG
L-4-hydroxyproline - Registration Dossier - ECHAL-4-hydroxyproline - Registration Dossier - ECHA
RCSB PDB - Protein Feature View - 4-hydroxyproline 2-epimerase - B9JQV3 (4HYPE AGRVS)RCSB PDB - Protein Feature View - 4-hydroxyproline 2-epimerase - B9JQV3 (4HYPE AGRVS)
Urinary hydroxyproline and thyroid diseaseUrinary hydroxyproline and thyroid disease
Hydroxyproline metabolism in mouse models of primary hyperoxaluria. | Sigma-AldrichHydroxyproline metabolism in mouse models of primary hyperoxaluria. | Sigma-Aldrich
Hydroxyproline assay | Scientist SolutionsHydroxyproline assay | Scientist Solutions
SYNTHESIS OF HYDROXYPROLINE IN VITRO BY THE HYDROXYLATION OF PROLINE IN A PRECURSOR OF COLLAGEN | PNASSYNTHESIS OF HYDROXYPROLINE IN VITRO BY THE HYDROXYLATION OF PROLINE IN A PRECURSOR OF COLLAGEN | PNAS
Mechanisms Mediating the Biologic Activity of Synthetic Proline, Glycine, and Hydroxyproline Polypeptides in Human NeutrophilsMechanisms Mediating the Biologic Activity of Synthetic Proline, Glycine, and Hydroxyproline Polypeptides in Human Neutrophils
CAS No.51-35-4,L-Hydroxyproline SuppliersCAS No.51-35-4,L-Hydroxyproline Suppliers
Hydroxyproline amino acid molecule - Stock Image F012/6060 - Science Photo LibraryHydroxyproline amino acid molecule - Stock Image F012/6060 - Science Photo Library
Polyphenolic Substance of Mytilus edulis: Novel Adhesive Containing L-Dopa and Hydroxyproline | SciencePolyphenolic Substance of Mytilus edulis: Novel Adhesive Containing L-Dopa and Hydroxyproline | Science
Hydroxyproline | Article about Hydroxyproline by The Free DictionaryHydroxyproline | Article about Hydroxyproline by The Free Dictionary
N-Acetyl-L-Hydroxyproline (AHYP™)N-Acetyl-L-Hydroxyproline (AHYP™)
Influence of Hydroxyproline Plasma Concentration on its Metabolism to OxalateInfluence of Hydroxyproline Plasma Concentration on its Metabolism to Oxalate
RCSB PDB - 4LB0: Crystal structure of a hydroxyproline epimerase from agrobacterium vitis, target efi-506420, with bound trans...RCSB PDB - 4LB0: Crystal structure of a hydroxyproline epimerase from agrobacterium vitis, target efi-506420, with bound trans...
The promising indicators for thermal and mechanical properties of collagen from bass and tilapia: Synergistic effect of...The promising indicators for thermal and mechanical properties of collagen from bass and tilapia: Synergistic effect of...
Hydroxyproline Colorimetric Assay Kit Kit-0472 - Creative BioMartHydroxyproline Colorimetric Assay Kit Kit-0472 - Creative BioMart
Sensitive determination of l-hydroxyproline in dairy products by capillary electrophoresis with in-capillary optical fiber...Sensitive determination of l-hydroxyproline in dairy products by capillary electrophoresis with in-capillary optical fiber...
Bioanalytical Method for the Determination of Hydroxyproline in Mouse Kidney by High-Performance Liquid Chromatography with...Bioanalytical Method for the Determination of Hydroxyproline in Mouse Kidney by High-Performance Liquid Chromatography with...
hydroxyproline assay to determine collagen content - Biology Forum | Biology-Online Dictionary, Blog & Forumhydroxyproline assay to determine collagen content - Biology Forum | Biology-Online Dictionary, Blog & Forum
Hydroxyproline Excretion and Height Velocity in Adolescent Boys | Archives of Disease in ChildhoodHydroxyproline Excretion and Height Velocity in Adolescent Boys | Archives of Disease in Childhood
Hydroxyproline excretion in idiopathic, congenital, and paralytic scoliosis | Archives of Disease in ChildhoodHydroxyproline excretion in idiopathic, congenital, and paralytic scoliosis | Archives of Disease in Childhood
A Developmentally Regulated Hydroxyproline-Rich Glycoprotein from the Cell Walls of Soybean Seed Coats | Plant PhysiologyA Developmentally Regulated Hydroxyproline-Rich Glycoprotein from the Cell Walls of Soybean Seed Coats | Plant Physiology
The location of arabinosyl:hydroxyproline transferase in the membrane system of potato tissue culture cells | Biochemical...The location of arabinosyl:hydroxyproline transferase in the membrane system of potato tissue culture cells | Biochemical...
Developmental localization and the role of hydroxyproline rich glycoproteins during somatic embryogenesis of banana (Musa spp....Developmental localization and the role of hydroxyproline rich glycoproteins during somatic embryogenesis of banana (Musa spp....
Hydroxyproline in wheat endosperm and wheat seedling rootsHydroxyproline in wheat endosperm and wheat seedling roots
AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and Processes
HydroxyprolineCollagenProlineHydroxylysineProcollagen-Proline DioxygenasePulmonary FibrosisBleomycinOsteitis DeformansUronic AcidsLiver Cirrhosis, ExperimentalPlant Somatic Embryogenesis TechniquesMicrobial CollagenaseAscorbic Acid DeficiencyAmino AcidsDesmosineProcollagenOxalatesPeplomycinCollagen Type IIIHydroxylationGlycolatesWound HealingCarbon TetrachlorideCollagen Type IGalactansBone and BonesFibrosisBone ResorptionLungAlkaline PhosphataseAnastomosis, SurgicalAmino Acid Metabolism, Inborn ErrorsGlycosaminoglycansLiver CirrhosisPhosphorusArabinoseDisease Models, AnimalProline OxidaseMusaRats, WistarHyperoxaluriaAntibodiesAntibody SpecificityAntibodies, MonoclonalRabbitsAntibodies, ViralAntibodies, BacterialCentrifugationTransition TemperatureAntibodies, ArchaealAntigens, ArchaealSolvents
UrineAmount of hydroxyprolineGlycoproteinsTotal hydroxyprolineMetabolismDeterminationProteinUrinary hydroxyproline excretionAssay for hydroxyprolineExcretion of hydroxyprolineDetermine collagenProteinsSerum hydroxyprolineResiduesHRGPsTissueMeasurementGlycineConversion of prolineTissuesMolecularEpimeraseCreatinine ratioProline hydroxylaseDegradationHypoxiaRacemicAmountsCollagen Triple HelixStructuralOxidationIminoGlutamicLevelsContentC5H9NO3LiverDerived from prolineBoneAssaysCompoundsGelatinCell WallsKidneyPrimary hyperoxaluriaStereoelectronic effectsPlantFibrosis
Urine12
Amount of hydroxyproline3
Glycoproteins4
Total hydroxyproline3
Metabolism6
Determination7
Protein10
Urinary hydroxyproline excretion4
Assay for hydroxyproline2
Excretion of hydroxyproline2
Determine collagen2
  • For this reason, hydroxyproline content has been used as an indicator to determine collagen and/or gelatin amount. (wikipedia.org)
  • Hi, I am trying to analyse the hydroxyproline to determine collagen content in rat heart samples, I am following Reddy and Enwemeka 1996 paper but unable to get a proper standard curve, even my blank (water) looks similar to my highest standard concentration (2--0ug). (biology-online.org)
Proteins8
Serum hydroxyproline3
Residues4
  • It was subsequently shown that the increase in stability is primarily through stereoelectronic effects and that hydration of the hydroxyproline residues provides little or no additional stability. (wikipedia.org)
  • The arabinose residues are attached to hydroxyproline mostly in the form of trisaccharides. (plantphysiol.org)
  • Is specific for AGPs containing non-contiguous peptidyl hydroxyproline residues. (icr.ac.uk)
  • Identification of plant hydroxyproline rich glycoprotein sequences by performing sequence bias and motif search, prediction of hydroxylated proline residues and scraping relevant data from web based prediction services. (rdrr.io)
HRGPs1
  • These results suggest that cell wall strengthening in S. graminicola-infected resistant pearl millet is brought about by a combination of polypeptide cross-linking of isodityrosine as well as by the high content of hydroxyproline in HRGPs, and H2O2, in contrast to the susceptible plant. (uni-mysore.ac.in)
Tissue6
Measurement4
Glycine3
Conversion of proline2
Tissues3
Molecular3
  • Trans-4-Hydroxy-L-proline CAS NO:51-35-4 L-Hydroxyproline Molecular Formula:C5H9NO3 Appearance: White crystals or crystalline powder Package:25kgs/drum Application:1. (lookchem.com)
  • for example, low molecular weight Bio Cell is combined with proline hydroxyproline and vitamin C for healthy skin and hair. (thefreedictionary.com)
  • Since dye-linked dehydrogenation activity for several unique compounds related to plants as substrates including opine(s) and l -hydroxyproline had been reported in bacterial cell-free extract from 1950s to 1980s, those genetic and molecular information have only recently been elucidated [ 3 , 4 , 5 , 6 ]. (intechopen.com)
Epimerase3
Creatinine ratio2
Proline hydroxylase1
  • Hydroxyproline is formed only as a post-translational modification in the peptide chain and proline hydroxylase does not hydroxylate free proline. (creativebiomart.net)
Degradation1
  • In the degradation pathway of bacteria, D-hydroxyproline dehydrogenase (HypDH) catalyzes the dehydrogenation reaction of cis-4-hydroxy-D-proline, and is classified into two types: homomeric and heteromeric enzymes. (intechopen.com)
Hypoxia2
  • In addition, we found that hydroxyproline promoted hypoxia- and HIF-dependent phenotype in HCC. (aacrjournals.org)
  • Moreover, we demonstrated that hypoxia activated proline biosynthesis via upregulation of ALDH18A1 , subsequently leading to accumulation of hydroxyproline via attenuated PRODH2 activity. (aacrjournals.org)
Racemic2
Amounts2
Collagen Triple Helix1
  • In the following, we present a computational study on the influence of stereoelectronic effects on the conformational properties of hydroxyproline and discuss the impact on the collagen triple-helix stability. (scienomics.com)
Structural1
  • Structural basis for the recognition of hydroxyproline in HIF-1 alpha by pVHL. (ox.ac.uk)
Oxidation2
  • Hydroxyproline oxidation was initiated by adding 50ul chloramine T solution to each well. (biology-online.org)
  • The so-called dye-linked dehydrogenases catalyze the oxidation of various biomolecules in the presence of an artificial electron acceptor, in which several unique compounds related to plants as substrates such as opine(s) and L-hydroxyproline are contained. (intechopen.com)
Imino1
  • Hydroxyproline (hydroxyproline), is one of the imino acids, usually with a hydroxyl group in the fourth position, but sometimes also in the third position. (grantprintinginc.com)
Glutamic1
Levels5
Content3
C5H9NO31
Liver2
  • Hydroxyproline (Hyp) catabolism, which occurs mainly in the liver and kidney, is a prominent source of glyoxylate and could account for a significant portion of the oxalate produced in PH. (sigmaaldrich.com)
  • Hydroxyproline is a nonessential amino acid, which means that it is manufactured from other amino acids in the liver. (healthmatters.io)
Derived from proline1
Bone2
  • Thirty-two men with stage D2 prostatic cancer were monitored by bone scan, acid and alkaline phosphatase values, and urinary hydroxyproline, beginning from 4 to 36 months after initiation of hormonal manipulation and/or systemic chemotherapy. (elsevier.com)
  • 4-hydroxyproline (Hyp) and prolyl dipeptides such as prolyl hydroxyproline (Pro-Hyp) have been found as disease biomarkers in the diagnosis of bone turnover and osteoporosis. (wichita.edu)
Assays1
  • The crystal structure of a hydroxylated HIF-1 alpha peptide bound to VCB (pVHL, elongins C and B) and solution binding assays reveal a single, conserved hydroxyproline-binding pocket in pVHL. (ox.ac.uk)
Compounds1
  • Biochemical assay showed serum ALT actions, serum AST actions, and information screening compounds of hepatic hydroxyproline had been markedly greater in rats injected with CCl4 for 12 wk, that are consistent using the histological observations. (thrombininhibitors.com)
Gelatin2
Cell Walls2
Kidney1
  • This study will also look at whether hydroxyproline is reabsorbed by the kidney and converted to glycolate and oxalate. (rarediseasesnetwork.org)
Primary hyperoxaluria2
Stereoelectronic effects1
  • In the following, we will present a work flow for analyzing the conformational preferences of hydroxyproline using MAPS software platform [15' and discuss the implications of stereoelectronic effects as structure directing element. (scienomics.com)
Plant1
Fibrosis1
  • Emodin could reduce the scores of hepatic fibrosis grading, inhibit the ALT and AST activities in serum and lowered the articles of hepatic hydroxyproline. (thrombininhibitors.com)
Anaerobic Animals Discovered on Sea Floor - The Scientific Activist
Anaerobic Animals Discovered on Sea Floor - The Scientific Activist (scienceblogs.com)
Anti-Hydroxyproline antibody (ab37067) | Abcam
Anti-Hydroxyproline antibody (ab37067) | Abcam (abcam.com)
Serial spot hydroxyproline/creatinine ratios in metastatic prostatic cancer<...
Serial spot hydroxyproline/creatinine ratios in metastatic prostatic cancer<... (miami.pure.elsevier.com)
The synthetic hydroxyproline-containing collagen analogue (Gly-Pro-Hyp) 10 promotes enzymatic activity of...
The synthetic hydroxyproline-containing collagen analogue (Gly-Pro-Hyp) 10 promotes enzymatic activity of... (scienceopen.com)
I think I now know why STURP chemist Raymond Rogers detected hydroxyproline in the blood on the Shroud - and it's to do with...
I think I now know why STURP chemist Raymond Rogers detected hydroxyproline in the blood on the Shroud - and it's to do with... (shroudofturinwithoutallthehype.wordpress.com)
Case study solution Can Be Fun For Anyone
Case study solution Can Be Fun For Anyone (juliuszlvdo.getblogs.net)
Pharmacological Targeting of Protease-Activated Receptor 2 Affords Protection from Bleomycin-Induced Pulmonary Fibrosis |...
Pharmacological Targeting of Protease-Activated Receptor 2 Affords Protection from Bleomycin-Induced Pulmonary Fibrosis |... (link.springer.com)
Protection from liver fibrosis by a peroxisome proliferator-activated receptor δ agonist | PNAS
Protection from liver fibrosis by a peroxisome proliferator-activated receptor δ agonist | PNAS (pnas.org)
Early detection and staging of chronic liver diseases with a protein MRI contrast agent | Nature Communications
Early detection and staging of chronic liver diseases with a protein MRI contrast agent | Nature Communications (nature.com)
B10.mdx Physiological Data
B10.mdx Physiological Data (jax.org)
Role of IFN-γ in Regulating T2 Immunity and the Development of Alternatively Activated Macrophages during Allergic...
Role of IFN-γ in Regulating T2 Immunity and the Development of Alternatively Activated Macrophages during Allergic... (jimmunol.org)
Therapeutic Attenuation of Pulmonary Fibrosis Via Targeting of IL-4- and IL-13-Responsive Cells | The Journal of Immunology
Therapeutic Attenuation of Pulmonary Fibrosis Via Targeting of IL-4- and IL-13-Responsive Cells | The Journal of Immunology (jimmunol.org)
Suppression of Discoidin Domain Receptor 1 by RNA Interference Attenuates Lung Inflammation | The Journal of Immunology
Suppression of Discoidin Domain Receptor 1 by RNA Interference Attenuates Lung Inflammation | The Journal of Immunology (jimmunol.org)
Label-free Raman monitoring of extracellular matrix formation in three-dimensional polymeric scaffolds | Journal of The Royal...
Label-free Raman monitoring of extracellular matrix formation in three-dimensional polymeric scaffolds | Journal of The Royal... (rsif.royalsocietypublishing.org)
Plus it
Plus it (jpet.aspetjournals.org)
Frontiers | Amifostine Analog, DRDE-30, Attenuates Bleomycin-Induced Pulmonary Fibrosis in Mice | Pharmacology
Frontiers | Amifostine Analog, DRDE-30, Attenuates Bleomycin-Induced Pulmonary Fibrosis in Mice | Pharmacology (frontiersin.org)
L-4-hydroxyproline - Registration Dossier - ECHA
L-4-hydroxyproline - Registration Dossier - ECHA (echa.europa.eu)
Frontiers | Placental Growth Factor Contributes to Liver Inflammation, Angiogenesis, Fibrosis in Mice by Promoting Hepatic...
Frontiers | Placental Growth Factor Contributes to Liver Inflammation, Angiogenesis, Fibrosis in Mice by Promoting Hepatic... (frontiersin.org)
Frontiers | Gene Mining for Proline Based Signaling Proteins in Cell Wall of Arabidopsis thaliana | Plant Science
Frontiers | Gene Mining for Proline Based Signaling Proteins in Cell Wall of Arabidopsis thaliana | Plant Science (frontiersin.org)
Ornithine - Wikipedia
Ornithine - Wikipedia (en.wikipedia.org)
Gamma-Aminobutyric acid - Wikipedia
Gamma-Aminobutyric acid - Wikipedia (en.wikipedia.org)
A gene-edited mouse model of limb-girdle muscular dystrophy 2C for testing exon skipping | Disease Models & Mechanisms
A gene-edited mouse model of limb-girdle muscular dystrophy 2C for testing exon skipping | Disease Models & Mechanisms (dmm.biologists.org)
The PDE4 inhibitor rolipram reverses object memory impairment induced by acute tryptophan depletion in the rat | SpringerLink
The PDE4 inhibitor rolipram reverses object memory impairment induced by acute tryptophan depletion in the rat | SpringerLink (link.springer.com)
Plasma amino acids: MedlinePlus Medical Encyclopedia
Plasma amino acids: MedlinePlus Medical Encyclopedia (medlineplus.gov)
Frontiers | Protective Effect of Ursolic Acid on the Intestinal Mucosal Barrier in a Rat Model of Liver Fibrosis | Physiology
Frontiers | Protective Effect of Ursolic Acid on the Intestinal Mucosal Barrier in a Rat Model of Liver Fibrosis | Physiology (frontiersin.org)
Polyphenolic Substance of Mytilus edulis: Novel Adhesive Containing L-Dopa and Hydroxyproline | Science
Polyphenolic Substance of Mytilus edulis: Novel Adhesive Containing L-Dopa and Hydroxyproline | Science (science.sciencemag.org)
Reducing power and iron chelating property of Terminalia chebula (Retz.) alleviates iron induced liver toxicity in mice | BMC...
Reducing power and iron chelating property of Terminalia chebula (Retz.) alleviates iron induced liver toxicity in mice | BMC... (bmccomplementalternmed.biomedcentral.com)
Acute downregulation of connexin43 at wound sites leads to a reduced inflammatory response, enhanced keratinocyte proliferation...
Acute downregulation of connexin43 at wound sites leads to a reduced inflammatory response, enhanced keratinocyte proliferation... (jcs.biologists.org)
Correlative GC-TOF-MS-based metabolite profiling and LC-MS-based protein profiling reveal time-related systemic regulation of...
Correlative GC-TOF-MS-based metabolite profiling and LC-MS-based protein profiling reveal time-related systemic regulation of... (link.springer.com)
EWG Skin Deep® | Suntegrity Skincare Impeccable Skin Moisturizing Face Sunscreen Lotion,
EWG Skin Deep® | Suntegrity Skincare Impeccable Skin Moisturizing Face Sunscreen Lotion, (ewg.org)
Category:Secondary alcohols - Wikimedia Commons
Category:Secondary alcohols - Wikimedia Commons (commons.wikimedia.org)
Medical Device Exemptions 510(k) and GMP Requirements
Medical Device Exemptions 510(k) and GMP Requirements (accessdata.fda.gov)
SYNTHESIS OF HYDROXYPROLINE IN VITRO BY THE HYDROXYLATION OF PROLINE IN A PRECURSOR OF COLLAGEN | PNAS
SYNTHESIS OF HYDROXYPROLINE IN VITRO BY THE HYDROXYLATION OF PROLINE IN A PRECURSOR OF COLLAGEN | PNAS (pnas.org)
What Is Gelatin Good For? Benefits, Uses and More
What Is Gelatin Good For? Benefits, Uses and More (healthline.com)
Clinical Chemistry and Laboratory Medicine
Clinical Chemistry and Laboratory Medicine (degruyter.com)
International Review of Connective Tissue Research - 1st Edition
International Review of Connective Tissue Research - 1st Edition (elsevier.com)
Rouge Hermes, Satin lipstick refill, Rouge H | Hermès USA
Rouge Hermes, Satin lipstick refill, Rouge H | Hermès USA (hermes.com)
Bone Markers in Osteoporosis: Bone Turnover Markers, Bone Formation Markers, Bone Resorption Markers
Bone Markers in Osteoporosis: Bone Turnover Markers, Bone Formation Markers, Bone Resorption Markers (emedicine.medscape.com)
IUCr) Acta Crystallographica Section B Volume 27, Part 10, October 1971
IUCr) Acta Crystallographica Section B Volume 27, Part 10, October 1971 (journals.iucr.org)
Overview of Amino Acid and Organic Acid Metabolism Disorders - Pediatrics - Merck Manuals Professional Edition
Overview of Amino Acid and Organic Acid Metabolism Disorders - Pediatrics - Merck Manuals Professional Edition (merckmanuals.com)