Hydrops Fetalis: Abnormal accumulation of serous fluid in two or more fetal compartments, such as SKIN; PLEURA; PERICARDIUM; PLACENTA; PERITONEUM; AMNIOTIC FLUID. General fetal EDEMA may be of non-immunologic origin, or of immunologic origin as in the case of ERYTHROBLASTOSIS FETALIS.Endolymphatic Hydrops: An accumulation of ENDOLYMPH in the inner ear (LABYRINTH) leading to buildup of pressure and distortion of intralabyrinthine structures, such as COCHLEA and SEMICIRCULAR CANALS. It is characterized by SENSORINEURAL HEARING LOSS; TINNITUS; and sometimes VERTIGO.Fetal Diseases: Pathophysiological conditions of the FETUS in the UTERUS. Some fetal diseases may be treated with FETAL THERAPIES.Parvovirus B19, Human: The type species of ERYTHROVIRUS and the etiological agent of ERYTHEMA INFECTIOSUM, a disease most commonly seen in school-age children.Parvoviridae Infections: Virus infections caused by the PARVOVIRIDAE.Blood Transfusion, Intrauterine: In utero transfusion of BLOOD into the FETUS for the treatment of FETAL DISEASES, such as fetal erythroblastosis (ERYTHROBLASTOSIS, FETAL).Erythroblastosis, Fetal: A condition characterized by the abnormal presence of ERYTHROBLASTS in the circulation of the FETUS or NEWBORNS. It is a disorder due to BLOOD GROUP INCOMPATIBILITY, such as the maternal alloimmunization by fetal antigen RH FACTORS leading to HEMOLYSIS of ERYTHROCYTES, hemolytic anemia (ANEMIA, HEMOLYTIC), general edema (HYDROPS FETALIS), and SEVERE JAUNDICE IN NEWBORN.alpha-Thalassemia: A disorder characterized by reduced synthesis of the alpha chains of hemoglobin. The severity of this condition can vary from mild anemia to death, depending on the number of genes deleted.Rh Isoimmunization: The process by which fetal Rh+ erythrocytes enter the circulation of an Rh- mother, causing her to produce IMMUNOGLOBULIN G antibodies, which can cross the placenta and destroy the erythrocytes of Rh+ fetuses. Rh isoimmunization can also be caused by BLOOD TRANSFUSION with mismatched blood.Hemoglobins, Abnormal: Hemoglobins characterized by structural alterations within the molecule. The alteration can be either absence, addition or substitution of one or more amino acids in the globin part of the molecule at selected positions in the polypeptide chains.Erythema Infectiosum: Contagious infection with human B19 Parvovirus most commonly seen in school age children and characterized by fever, headache, and rashes of the face, trunk, and extremities. It is often confused with rubella.Fetal Death: Death of the developing young in utero. BIRTH of a dead FETUS is STILLBIRTH.Hydrothorax: A collection of watery fluid in the pleural cavity. (Dorland, 27th ed)Cystic Adenomatoid Malformation of Lung, Congenital: An abnormality in lung development that is characterized by a multicystic mass resulting from an adenomatous overgrowth of the terminal BRONCHIOLES with a consequent reduction of PULMONARY ALVEOLI. This anomaly is classified into three types by the cyst size.Prenatal Diagnosis: Determination of the nature of a pathological condition or disease in the postimplantation EMBRYO; FETUS; or pregnant female before birth.Polyhydramnios: A condition of abnormally high AMNIOTIC FLUID volume, such as greater than 2,000 ml in the LAST TRIMESTER and usually diagnosed by ultrasonographic criteria (AMNIOTIC FLUID INDEX). It is associated with maternal DIABETES MELLITUS; MULTIPLE PREGNANCY; CHROMOSOMAL DISORDERS; and congenital abnormalities.Ultrasonography, Prenatal: The visualization of tissues during pregnancy through recording of the echoes of ultrasonic waves directed into the body. The procedure may be applied with reference to the mother or the fetus and with reference to organs or the detection of maternal or fetal disease.Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.alpha-Globins: Members of the alpha-globin family. In humans, they are encoded in a gene cluster on CHROMOSOME 16. They include zeta-globin and alpha-globin. There are also pseudogenes of zeta (theta-zeta) and alpha (theta-alpha) in the cluster. Adult HEMOGLOBIN is comprised of 2 alpha-globin chains and 2 beta-globin chains.Hemoglobin H: An abnormal hemoglobin composed of four beta chains. It is caused by the reduced synthesis of the alpha chain. This abnormality results in ALPHA-THALASSEMIA.Edema: Abnormal fluid accumulation in TISSUES or body cavities. Most cases of edema are present under the SKIN in SUBCUTANEOUS TISSUE.Abortion, Eugenic: Abortion performed because of possible fetal defects.Mucopolysaccharidosis VII: Mucopolysaccharidosis characterized by excessive dermatan and heparan sulfates in the urine and Hurler-like features. It is caused by a deficiency of beta-glucuronidase.Infant, Newborn: An infant during the first month after birth.Phosphotransferases (Phosphomutases): A group of enzymes that catalyze an intramolecular transfer of a phosphate group. It has been shown in some cases that the enzyme has a functional phosphate group, which can act as the donor. These were previously listed under PHOSPHOTRANSFERASES (EC 2.7.-). (From Enzyme Nomenclature, 1992) EC 5.4.2.Thalassemia: A group of hereditary hemolytic anemias in which there is decreased synthesis of one or more hemoglobin polypeptide chains. There are several genetic types with clinical pictures ranging from barely detectable hematologic abnormality to severe and fatal anemia.Hypoalbuminemia: A condition in which albumin level in blood (SERUM ALBUMIN) is below the normal range. Hypoalbuminemia may be due to decreased hepatic albumin synthesis, increased albumin catabolism, altered albumin distribution, or albumin loss through the urine (ALBUMINURIA).Gestational Age: The age of the conceptus, beginning from the time of FERTILIZATION. In clinical obstetrics, the gestational age is often estimated as the time from the last day of the last MENSTRUATION which is about 2 weeks before OVULATION and fertilization.Amniocentesis: Percutaneous transabdominal puncture of the uterus during pregnancy to obtain amniotic fluid. It is commonly used for fetal karyotype determination in order to diagnose abnormal fetal conditions.Meniere Disease: A disease of the inner ear (LABYRINTH) that is characterized by fluctuating SENSORINEURAL HEARING LOSS; TINNITUS; episodic VERTIGO; and aural fullness. It is the most common form of endolymphatic hydrops.Fatal Outcome: Death resulting from the presence of a disease in an individual, as shown by a single case report or a limited number of patients. This should be differentiated from DEATH, the physiological cessation of life and from MORTALITY, an epidemiological or statistical concept.Pregnancy Complications, Infectious: The co-occurrence of pregnancy and an INFECTION. The infection may precede or follow FERTILIZATION.Lymphatic Abnormalities: Congenital or acquired structural abnormalities of the lymphatic system (LYMPHOID TISSUE) including the lymph vessels.Heart Septal Defects, Atrial: Developmental abnormalities in any portion of the ATRIAL SEPTUM resulting in abnormal communications between the two upper chambers of the heart. Classification of atrial septal defects is based on location of the communication and types of incomplete fusion of atrial septa with the ENDOCARDIAL CUSHIONS in the fetal heart. They include ostium primum, ostium secundum, sinus venosus, and coronary sinus defects.Heart Septal Defects, Ventricular: Developmental abnormalities in any portion of the VENTRICULAR SEPTUM resulting in abnormal communications between the two lower chambers of the heart. Classification of ventricular septal defects is based on location of the communication, such as perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular defect.Hypertension, Malignant: A condition of markedly elevated BLOOD PRESSURE with DIASTOLIC PRESSURE usually greater than 120 mm Hg. Malignant hypertension is characterized by widespread vascular damage, PAPILLEDEMA, retinopathy, HYPERTENSIVE ENCEPHALOPATHY, and renal dysfunction.Cardiomyopathies: A group of diseases in which the dominant feature is the involvement of the CARDIAC MUSCLE itself. Cardiomyopathies are classified according to their predominant pathophysiological features (DILATED CARDIOMYOPATHY; HYPERTROPHIC CARDIOMYOPATHY; RESTRICTIVE CARDIOMYOPATHY) or their etiological/pathological factors (CARDIOMYOPATHY, ALCOHOLIC; ENDOCARDIAL FIBROELASTOSIS).Syndrome: A characteristic symptom complex.Infant, Premature: A human infant born before 37 weeks of GESTATION.Cephalopelvic Disproportion: A condition in which the HEAD of the FETUS is larger than the mother's PELVIS through which the fetal head must pass during a vaginal delivery.Pelvimetry: Measurement of the dimensions and capacity of the pelvis. It includes cephalopelvimetry (measurement of fetal head size in relation to maternal pelvic capacity), a prognostic guide to the management of LABOR, OBSTETRIC associated with disproportion.Vacuum Extraction, Obstetrical: Removal of the fetus from the uterus or vagina at or near the end of pregnancy with a metal traction cup that is attached to the fetus' head. Negative pressure is applied and traction is made on a chain passed through the suction tube. (From Stedman, 26th ed & Dorland, 28th ed)Vascular Malformations: A spectrum of congenital, inherited, or acquired abnormalities in BLOOD VESSELS that can adversely affect the normal blood flow in ARTERIES or VEINS. Most are congenital defects such as abnormal communications between blood vessels (fistula), shunting of arterial blood directly into veins bypassing the CAPILLARIES (arteriovenous malformations), formation of large dilated blood blood-filled vessels (cavernous angioma), and swollen capillaries (capillary telangiectases). In rare cases, vascular malformations can result from trauma or diseases.Rh-Hr Blood-Group System: Erythrocyte isoantigens of the Rh (Rhesus) blood group system, the most complex of all human blood groups. The major antigen Rh or D is the most common cause of erythroblastosis fetalis.Mothers: Female parents, human or animal.ABO Blood-Group System: The major human blood type system which depends on the presence or absence of two antigens A and B. Type O occurs when neither A nor B is present and AB when both are present. A and B are genetic factors that determine the presence of enzymes for the synthesis of certain glycoproteins mainly in the red cell membrane.Blood Group Antigens: Sets of cell surface antigens located on BLOOD CELLS. They are usually membrane GLYCOPROTEINS or GLYCOLIPIDS that are antigenically distinguished by their carbohydrate moieties.Fetus: The unborn young of a viviparous mammal, in the postembryonic period, after the major structures have been outlined. In humans, the unborn young from the end of the eighth week after CONCEPTION until BIRTH, as distinguished from the earlier EMBRYO, MAMMALIAN.Aortopulmonary Septal Defect: A developmental abnormality in which the spiral (aortopulmonary) septum failed to completely divide the TRUNCUS ARTERIOSUS into ASCENDING AORTA and PULMONARY ARTERY. This abnormal communication between the two major vessels usually lies above their respective valves (AORTIC VALVE; PULMONARY VALVE).Cor Triatriatum: A malformation of the heart in which the embryonic common PULMONARY VEIN was not incorporated into the LEFT ATRIUM leaving behind a perforated fibromuscular membrane bisecting the left atrium, a three-atrium heart. The opening between the two left atrium sections determines the degree of obstruction to pulmonary venous return, pulmonary venous and pulmonary arterial hypertension.Pleural Effusion: Presence of fluid in the pleural cavity resulting from excessive transudation or exudation from the pleural surfaces. It is a sign of disease and not a diagnosis in itself.
Fetal tachycardias: management and outcome of 127 consecutive cases. (1/193)
OBJECTIVE: To review the management and outcome of fetal tachycardia, and to determine the problems encountered with various treatment protocols. STUDY DESIGN: Retrospective analysis. SUBJECTS: 127 consecutive fetuses with a tachycardia presenting between 1980 and 1996 to a single tertiary centre for fetal cardiology. The median gestational age at presentation was 32 weeks (range 18 to 42). RESULTS: 105 fetuses had a supraventricular tachycardia and 22 had atrial flutter. Overall, 52 fetuses were hydropic and 75 non-hydropic. Prenatal control of the tachycardia was achieved in 83% of treated non-hydropic fetuses compared with 66% of the treated hydropic fetuses. Digoxin monotherapy converted most (62%) of the treated non-hydropic fetuses, and 96% survived through the neonatal period. First line drug treatment for hydropic fetuses was more diverse, including digoxin (n = 5), digoxin plus verapamil (n = 14), and flecainide (n = 27). The response rates to these drugs were 20%, 57%, and 59%, respectively, confirming that digoxin monotherapy is a poor choice for the hydropic fetus. Response to flecainide was faster than to the other drugs. Direct fetal treatment was used in four fetuses, of whom two survived. Overall, 73% (n = 38) of the hydropic fetuses survived. Postnatally, 4% of the non-hydropic group had ECG evidence of pre-excitation, compared with 16% of the hydropic group; 57% of non-hydropic fetuses were treated with long term anti-arrhythmics compared with 79% of hydropic fetuses. CONCLUSIONS: Non-hydropic fetuses with tachycardias have a very good prognosis with transplacental treatment. Most arrhythmias associated with fetal hydrops can be controlled with transplacental treatment, but the mortality in this group is 27%. At present, there is no ideal treatment protocol for these fetuses and a large prospective multicentre trial is required to optimise treatment of both hydropic and non-hydropic fetuses. (+info)Intrauterine management of fetal parvovirus B19 infection. (2/193)
OBJECTIVES: The aim of our study was to determine the outcome of pregnancies after intrauterine management of fetal parvovirus B19 infection. DESIGN: Retrospective study. SUBJECTS: A total of 37 cases of maternofetal parvovirus B19 infection, 35 of which were associated with hydrops fetalis, were referred to our tertiary level center between 1989 and 1996. With regard to fetal hydrops, no apparent cause other than parvovirus B19 infection was found in any patient. METHODS: In all patients, cordocentesis was performed to assess the degree of fetal anemia. When anemia was present, cordocentesis was followed by intrauterine transfusion with packed red cells into the umbilical vein. Further management depended on the degree of fetal anemia and gestational age and included follow-up fetal blood sampling/transfusion as well as ultrasound examinations as deemed appropriate. RESULTS: Packed red cell transfusion was performed in 30 patients with significant fetal anemia (Z-score 1.6-7.8 below the mean for gestational age). The fetal hemoglobin values ranged from 2.1 to 9.6 g/dl. Serum levels of platelets in the transfusion group were 9-228 x 10(9)/l with Z-scores in the range of < 1 to 3.8 below the mean. During treatment and follow-up, there were five intrauterine deaths (13.5%), one neonatal death (2.7%) and 31 live births (83.8%). CONCLUSIONS: Fetal parvovirus infection can lead to marked anemia and hydrops formation. Cordocentesis allows precise assessment of fetal anemia which can then be corrected by intravenous transfusion. Under this regimen, the outcome proved favorable in the majority of fetuses, even those that were severely anemic. (+info)Direct intrauterine fetal therapy in a case of bronchopulmonary sequestration associated with non-immune hydrops fetalis. (3/193)
Bronchopulmonary sequestration associated with non-immune hydrops fetalis is generally recognized as a uniformly fatal fetal condition without fetal surgical intervention. We describe here the first case of such a condition treated successfully with direct intrauterine fetal therapy using digoxin and frusemide. (+info)Endothelin concentrations in monochorionic twins with severe twin-twin transfusion syndrome. (4/193)
The objective of this study was to determine endothelin (ET-1) concentrations in monochorionic twin fetuses with and without twin-twin transfusion syndrome (TTTS). Fourteen monochorionic twin pregnancies complicated by TTTS and six without TTTS were studied. Matched maternal and fetal blood samples were obtained both in utero and at birth. Amniotic fluid samples were also collected from twin pairs. ET-1 concentrations were measured by radio-immunoassay. ET-1 concentrations in recipient fetuses were higher than in the donors both in utero(P < 0.001) and at birth (P < 0.01). Fetal concentrations of ET-1 in donors were similar to non-TTTS twins. Plasma ET-1 concentrations were significantly higher (P < 0.01) in recipient fetuses with severe hydrops than those with mild/no hydrops. Maternal concentrations of ET-1 were comparable in the two groups. Endothelin concentrations in recipient twins were 2(1/2) times higher than in their co-twins and this was related to the severity of hydrops. (+info)Prenatal diagnosis of parvovirus B19-induced hydrops fetalis by chemiluminescence in situ hybridization. (5/193)
Parvovirus B19 can be transmitted transplacentally from the infected mother to the fetus during pregnancy, and hydrops fetalis, abortion, or stillbirth can result. In our study we explored the use of chemiluminescence in situ hybridization to detect B19 DNA on cord blood cells, amniotic fluid cells, and pleuric fluid cells from several cases of hydrops fetalis. B19 DNA was detected by using digoxigenin-labeled probes immunoenzymatically visualized with the chemiluminescent adamantil-1,2-dioxetane phenyl phosphate substrate for alkaline phosphatase. The luminescent signal emitted from the hybridized probes was detected, analyzed, and measured with a high-performance, low-light-level imaging luminograph connected to an optical microscope and to a personal computer for the quantification and localization of the chemiluminescent emission inside individual cells. (+info)Mapping of a new SGBS locus to chromosome Xp22 in a family with a severe form of Simpson-Golabi-Behmel syndrome. (6/193)
Simpson-Golabi-Behmel syndrome (SGBS) is an X-linked overgrowth syndrome with associated visceral and skeletal abnormalities. Alterations in the glypican-3 gene (GPC3), which is located on Xq26, have been implicated in the etiology of relatively milder cases of this disorder. Not all individuals with SGBS have demonstrated disruptions of the GPC3 locus, which raises the possibility that other loci on the X chromosome could be responsible for some cases of this syndrome. We have previously described a large family with a severe form of SGBS that is characterized by multiple anomalies, hydrops fetalis, and death within the first 8 wk of life. Using 25 simple tandem-repeat polymorphism markers spanning the X chromosome, we have localized the gene for this disorder to an approximately 6-Mb region of Xp22, with a maximum LOD score of 3.31 and with LOD scores <-2.0 for all of Xq. These results demonstrate that neither the GPC3 gene nor other genes on Xq26 are responsible for all cases of SGBS and that a second SGBS locus resides on Xp22. (+info)Parvovirus B19 infections. (7/193)
Infections caused by human parvovirus B19 can result in a wide spectrum of manifestations, which are usually influenced by the patient's immunologic and hematologic status. In the normal host, parvovirus infection can be asymptomatic or can result in erythema infectiosum or arthropathy. Patients with underlying hematologic and immunologic disorders who become infected with this virus are at risk for aplastic anemia. Hydrops fetalis and fetal death are complications of intrauterine parvovirus B19 infection. (+info)Atrial flutter in the perinatal age group: diagnosis, management and outcome. (8/193)
OBJECTIVES: The aim of this retrospective study was to evaluate perinatal atrial flutter (AF) and the efficacy of maternally administered antiarrhythmic agents, postpartum management and outcome. BACKGROUND: Perinatal AF is a potentially lethal arrhythmia, and management of this disorder is difficult and controversial. METHODS: Forty-five patients with documented AF were studied retrospectively. RESULTS: Atrial flutter was diagnosed prenatally in 44 fetuses and immediately postnatally in 1 neonate. Fetal hydrops was seen in 20 patients; 17 received maternal therapy, 2 were delivered and 1 was not treated because it had a severe nontreatable cardiac malformation. In the nonhydropic group of 24 patients, 18 were treated and the remaining 6 were delivered immediately. In the hydropic group, 10 received single-drug therapy (digoxin or sotalol) and 7 received multidrug therapy. In the nonhydropic group, 13 received a single drug (digoxin or sotalol) and 5 received multiple drugs. One patient with rapid 1:1 atrioventricular conduction (heart rate 480 beats/min) died in utero and another died due to a combination of severe hydrops because of the AF, sotalol medication, stenosis of the venous duct and hypoplastic placenta. Of the 43 live-born infants, 12 were in AF at birth. Electrical cardioversion was successful in eight of nine patients. No recurrences in AF have occurred beyond the neonatal period. Four patients with fetal flutter and hydrops showed significant neurological pathology immediately after birth. CONCLUSIONS: Fetal AF is a serious and threatening rhythm disorder, particularly when it causes hydrops, it may be associated with fetal death or neurological damage. Treatment is required and primarily aimed at reaching an adequate ventricular rate and preferably conversion to sinus rhythm. Digoxin failed in prevention of recurrence at time of delivery in a quarter of our patients, whereas with sotalol no recurrence of AF has been reported, suggesting that class III agents may be the future therapy. Once fetuses with AF survive without neurological pathology, their future is good and prophylaxis beyond the neonatal period is unnecessary. (+info)Nonimmune hydropsFetusUltrasoundNIHFLymphatic dysplasiaEtiologySevere casesCaseBabyImmuneEdemaPolyhydramniosSevereAscitesMaternalErythroblastosisCases of hydrops fetalisTreatment of Hydrops FetalisBart'sAnemiaFetusesComplicationsIncompatibilityAccumulationMediastinalSymptomsCysticNeonateAtrial septalType of hydropsChromosomal abnormalitiesDepends on the causeInfantParvovirusPremature
- Nonimmune hydrops fetalis is the final common pathway of many conditions that ultimately result in fetal anasarca. (aappublications.org)
- To our knowledge, this is the first report of midaortic syndrome as an etiology for nonimmune hydrops fetalis. (aappublications.org)
- A case of nonimmune hydrops fetalis with a rare cardiac anomaly in a rhesus monkey. (elsevier.com)
- A case of nonimmune hydrops fetalis in a rhesus monkey was identified by ultrasound. (elsevier.com)
- Researchers funded by the National Institutes of Health have used a rapid DNA sequencing technique to identify gene variants in roughly a third of cases of nonimmune Hydrops fetalis ( NIHF ), a serious condition in which a fetus develops fluid buildup inside the abdominal cavity, lungs, or other parts of the body. (nih.gov)
- Exome sequencing for prenatal diagnosis in nonimmune hydrops fetalis. (nih.gov)
- We present a case of midaortic syndrome, also known as abdominal coarctation syndrome, in a fetus with hydrops and a severe cardiomyopathy. (aappublications.org)
- Why does the Rh factor react with the fetus and cause hydrops fetalis? (ndtv.com)
- Why do other blood group antigens like A, O, AB and B from the mother side not react with the fetus and why does only the Rh factor react with fetus and cause hydrops fetalis ? (ndtv.com)
- Hydrops fetalis is a serious condition of the fetus or newborn. (nicklauschildrens.org)
- 35 years old primigravid -first time pregnant ) and initial ultrasound during middle of pregnancy revealed hydrops fetalis. (wordpress.com)
- The objective of our study was to evaluate the usefulness of immunohistochemical (IHC) staining techniques in the etiological diagnosis of non-immune hydrops fetalis (NIHF). (elsevier.com)
- In conclusion, specific IHC staining techniques aimed at detecting lymphatic dysplasia are needed and should be mandatory in autopsies of fetuses with non-immune hydrops fetalis. (elsevier.com)
- Even after extensive evaluation, the etiology of a small percentage of cases of hydrops remains unknown. (aappublications.org)
- The typical diagnostic findings are jaundice, pallor, hepatosplenomegaly, and hydrops fetalis in severe cases. (ndtv.com)
- I received a call of referral to attend to the delivery of a baby who was initially diagnosed as a case of hydrops fetalis (baby is swollen all over his body). (wordpress.com)
- Baby had no hydrops, instead he has a mass (tumor) at the abdomen. (wordpress.com)
- There are two types of hydrops fetalis, immune and nonimmune. (medlineplus.gov)
- Immune hydrops fetalis is most often a complication of a severe form of Rh incompatibility , which can be prevented. (medlineplus.gov)
- The number of babies who develop immune hydrops fetalis has dropped due to a medicine called RhoGAM. (medlineplus.gov)
- There are other, much rarer, blood group incompatibilities that can also cause immune hydrops fetalis, but RhoGAM does not help with these. (medlineplus.gov)
- For immune hydrops, direct transfusion of red blood cells that match the infant's blood type. (medlineplus.gov)
- Non-immune hydrops can also be unrelated to anemia, for example if a fetal tumor or congenital cystic adenomatoid malformation increases the demand for blood flow. (wikipedia.org)
- Rh disease is an increasingly uncommon cause of immune-mediated hydrops fetalis. (wikipedia.org)
- However, a small percentage of pregnant mothers are still susceptible to Rh disease even after receiving anti-D IgG (Rho(D) Immune Globulin) The non-immune form of hydrops fetalis has many causes including: Iron deficiency anemia Paroxysmal supraventricular tachycardia resulting in heart failure Deficiency of the enzyme beta-glucuronidase. (wikipedia.org)
- A form of non-immune hydrops fetalis, a condition characterized by fluid accumulation in at least 2 fetal compartments, including abdominal cavities, pleura, and pericardium, or in body tissue. (uniprot.org)
- Immune hydrops may develop because of Rh disease in the mother. (nyhq.org)
- Non-immune hydrops includes all other diseases or complications that may interfere with the baby's ability to manage fluid. (nyhq.org)
- There is no one mechanism to explain non-immune hydrops. (nyhq.org)
- Immune hydrops is not as common as it used to be since the widespread use of Rh immunoglobulin treatment for Rh negative women. (nyhq.org)
- Non-immune hydrops occurs rarely. (nyhq.org)
- Intrauterine treatment on non-immune hydrops fetalis. (pptaglobal.org)
- We reported the first patient with early onset cobalamin C disease ( cbl C) who presented with non-immune hydrops fetalis, who also had left ventricular noncompaction (LVNC) and heart failure in the neonatal period. (springer.com)
- There are two types of hydrops fetalis - Immune Hydrops Fetalis and Non-Immune Hydrops Fetalis. (firstcry.com)
- Extreme cases of Rh-incompatibility can cause immune hydrops. (firstcry.com)
- Non-immune hydrops fetalis is more common and occurs when some kind of disease or ailment hampers with the body's ability to regulate fluids. (firstcry.com)
- Some of the health conditions that can lead to non-immune hydrops fetalis include chromosomal abnormalities , congenital infections, severe anaemia , etc. (firstcry.com)
- If the baby has immune hydrops, she could receive a red blood transfusion. (firstcry.com)
- Immune Hydrops Fetalis, also known as immune fetal hydrops , is related to hydrops fetalis, nonimmune and hydrops fetalis . (malacards.org)
- An important gene associated with Immune Hydrops Fetalis is GUSB (Glucuronidase Beta), and among its related pathways/superpathways are Lysosome and Binding and Uptake of Ligands by Scavenger Receptors . (malacards.org)
- Fetal hydrops can be immune or nonimmune. (exxcellence.org)
- Immune hydrops - They might develop because of Rh disease that is present in the mother. (medicalfoxx.com)
- Cholestasis is a common problem in infants with immune hydrops fetalis (IHF). (acibadem.edu.tr)
- The objective of our study was to evaluate the usefulness of immunohistochemical (IHC) staining techniques in the etiological diagnosis of non-immune hydrops fetalis (NIHF). (elsevier.com)
- In conclusion, specific IHC staining techniques aimed at detecting lymphatic dysplasia are needed and should be mandatory in autopsies of fetuses with non-immune hydrops fetalis. (elsevier.com)
- A case of non immune hydrops fetalis presenting at 22 weeks of pregnancy was studied by detailed analysis of the fetal blood obtained by ultrasound guided cordocentesis. (who.int)
- In this study, 40 pregnant women with gestational age of approximately 25 weeks, prenatal diagnosis of non immune hydrops fetalis and suspected of human parvovirus B19 infection were studied between January 1999 and December 2005. (bvsalud.org)
- Non-immune hydrops fetalis as a diagnostic and survival problems: what do we tell the parents? (degruyter.com)
- Hydrops fetalis , which is characterized by extreme edema (abnormal accumulation of serous fluid) and congestive heart failure, is the most severe form of the disease in newborns. (britannica.com)
- Twin-twin transfusion syndrome in pregnancies in which twins share a single placenta (hydrops affects the recipient twin) Maternal hyperthyroidism Fetal cardiac defects and skeletal defects Noonan syndrome Mirror syndrome, in which fetal and placental hydrops develops in association with maternal preeclampsia, edema and hypertension Hydrops fetalis can be diagnosed and monitored by ultrasound scans. (wikipedia.org)
- The severe edema that occurs with hydrops can overtake the baby's organ systems. (nyhq.org)
- fetal hydrops ( hydrops feta´lis ) gross edema of the entire body of the newborn infant, in erythroblastosis fetalis. (thefreedictionary.com)
- Hydrops fetalis is the presence of excessive fluid in two or more fetal compartments including skin edema, pleural effusion, pericardial effusion, ascites, and polyhydramnios. (exxcellence.org)
- Hydrops fetalis which is also known as hydrops, is a life-threatening condition in which an abnormal fluid is accumulated in two or more fetal compartments such as skin edema, pleural effusion, and pericardial effusion. (medicalfoxx.com)
- En fetalis de los hydrops, el edema severo y peligroso para la vida (hinchazón) se convierte mientras que el líquido aumenta y rodea los pulmones, el abdomen y el corazón del feto. (news-medical.net)
- Ultrasound examination confirmed fetal hydrops with hydrothorax and ascitis, fetal anemia (middle cerebral artery peak systolic velocity: 74.3 cm/sg with an estimated haemoglobin of 7.14 g/dl), polyhydramnios (maximum pocket 14), estimated fetal weight of 2460 g and mild cardiomegaly (cardiac area more than 1/3 of thoracic area) with hyperdinamic heart circulation. (biomedcentral.com)
- Moreover, we report that both homozygous mutants develop polyhydramnios, hydrops fetalis, spina bifida occulta and osteochondrodysplasia. (nih.gov)
- The typical diagnostic findings are jaundice, pallor, hepatosplenomegaly, and hydrops fetalis in severe cases. (ndtv.com)
- Hydrops Fetalis is a severe and life-threatening condition that can affect fetuses or newborn babies. (firstcry.com)
- Hb Bart's hydrops fetalis is the most severe form of alpha-thalassemia (see this term) and is almost always lethal. (mendelian.co)
- We report a case of giant chorioangioma with fetal hydrops, additionally complicated by severe anemia, mild cardiomegaly with hyperdinamic heart circulation and maternal mirror syndrome. (biomedcentral.com)
- Our outcome raises the issue whether additional intrauterine clinical intervention, as intersticial laser, should have been performed to stop further deterioration of the fetal condition when progressive severe hydrops develops. (biomedcentral.com)
- A 34-year-old woman, gravida 1, was referred to our Department at 29 weeks´ gestation because of placental chorioangioma, severe hydrops fetalis, suspected fetal anemia and maternal mirror syndrome (Ballantine's syndrome), previously not detected. (biomedcentral.com)
- A newborn with hydrops fetalis may have severe swelling of their entire body. (chkd.org)
- Severe G6PD deficiency can cause severe anemia and increased bilirubin and can cause hydrops fetalis. (healthtap.com)
- Exposure by Mom to certain drugs, certain foods--fava bean-- exposure to moth balls napthalene--can trigger a severe reaction and may be responsible for hydrops fetalis. (healthtap.com)
- The abnormal collection of fluid in more than one area of the fetal body, ascites or effusions, is termed hydrops fetalis. (healthtap.com)
- Lysosomal storage disorders (LSD) are a rare cause of non immunological hydrops fetalis (NIHF) and congenital ascites. (nih.gov)
- We report four cases with transient hydrops fetalis resulting from LSD and performed a literature review on LSD with NIHF and congenital ascites in combination. (nih.gov)
- Enzymatic studies in chorionic villous sample or amniotic cultured cells, once the most common conditions associated with fetal ascites or hydrops have been ruled out, are important. (nih.gov)
- We experienced a case of hydrops fetalis with subcutaneous lymphedema, chylothorax, chylous ascites and pericardial effusion. (bvsalud.org)
- Congenital disorders of glycosylation Parvovirus B19 (fifth disease) infection of the pregnant woman Cytomegalovirus in mother Congenital pulmonary airway malformation Maternal syphilis and maternal diabetes mellitus Alpha-thalassemia can also cause hydrops fetalis when all four of the genetic loci for α globin are deleted or affected by mutation. (wikipedia.org)
- Timely referral to a maternal-fetal medicine specialist allows for detailed and comprehensive ultrasonographic examination and the early identification of any treatable causes of fetal hydrops. (medscape.com)
- If fetal hydrops is suspected, syphilis serology is mandatory, with repeat serial testing and, very importantly, with dilution of maternal serum. (medscape.com)
- The prozone effect has been demonstrated repeatedly with fetal hydrops due to syphilis, thus dilution of maternal serum to avoid false-negative results is required. (medscape.com)
- Maternal serum screening tests (multiple-marker, triple-screen, triple-marker), commonly used if fetal anomaly is suspected, are of uncertain value with fetal hydrops. (medscape.com)
- Bernstein, I.M., and Capeless, E.L.: Elevated maternal serum alpha-fetoprotein and hydrops fetalis in association with fetal parvovirus B-19 infection. (springer.com)
- The clinical features of erythroblastosis fetalis result from destruction of fetal RBCs by maternal antibodies against them. (medindia.net)
- What is Erythroblastosis Fetalis? (medindia.net)
- What are the Causes of Erythroblastosis Fetalis? (medindia.net)
- Erythroblastosis fetalis can be caused due to incompatibility of either of two major blood types. (medindia.net)
- The fetal bone marrow reacts to the hemolytic anemia by releasing immature RBCs called erythroblasts into the fetal peripheral circulation, causing erythroblastosis fetalis. (medindia.net)
- What are the Symptoms and Signs of Erythroblastosis Fetalis? (medindia.net)
- How do you Diagnose Erythroblastosis Fetalis? (medindia.net)
- It's also called erythroblastosis fetalis. (chkd.org)
- This is called erythroblastosis fetalis during pregnancy. (chkd.org)
- There was a total of 75 identified cases of hydrops fetalis. (actamedicaphilippina.com.ph)
- The rate of survival often depends on the cause and treatment of hydrops fetalis. (medicalfoxx.com)
- Detection of [alpha]-thalassemia in [beta]-thalassemia carriers and prevention of Hb Bart's hydrops fetalis through prenatal screening. (thefreedictionary.com)
- Hb Bart's Hydrops Fetalis Is also known as alpha-thalassemia major, alpha-thalassemia hydrops fetalis, homozygous alpha0-thalassemia, hemoglobin bart's hydrops fetalis. (mendelian.co)
- Alpha thalassemia major with hemoglobin Bart's usually results in fatal hydrops fetalis. (aafp.org)
- Hydrops fetalis usually stems from fetal anemia, when the heart needs to pump a much greater volume of blood to deliver the same amount of oxygen. (wikipedia.org)
- Hydrops can develop as the baby's organs are unable to compensate for the anemia. (nyhq.org)
- Hydrops may resolve in some cases when the anemia is corrected. (exxcellence.org)
- Hydrops fetalis can form as the organs of the baby are not able to make up for the anemia. (medicalfoxx.com)
- In one study, positive screening tests (any of the three used) with only a 60% sensitivity in 19 cases of Turner syndrome distinguished some fetuses with cystic hygroma and/or hydrops from those without. (medscape.com)
- The deficiency has presented as hydrops fetalis and HELLP syndrome in fetuses. (wikipedia.org)
- If left untreated, hydrops can stress the baby's vital organs and lead to life-threatening complications. (firstcry.com)
- This is a type of hydrops which occurs when there is an RH-incompatibility between the fetal and mother's blood. (firstcry.com)
- Fetal metabolic storage diseases cause hydrops due to congestion caused by accumulation of metabolites in the liver and other abdominal viscera. (exxcellence.org)
- Fetal mediastinal teratomas are rare tumors that cause hydrops fetalis or fetal demise in the prenatal period and respiratory distress in the neonatal period. (elsevier.com)
- Mediastinal shift and hydrops fetalis are indications for fetal intervention. (nature.com)
- What are the symptoms of hydrops fetalis? (nyhq.org)
- The following are the most common symptoms of hydrops fetalis. (nyhq.org)
- The symptoms of hydrops fetalis may resemble other conditions or medical problems. (nyhq.org)
- The treatment depends on the cause of hydrops fetalis, and if no evident cause is established, the doctor may suggest measures to ease the symptoms. (firstcry.com)
- Symptoms vary on the severity of hydrops fetalis and may differ on each baby. (medicalfoxx.com)
- Turner syndrome with cystic hygroma and hydrops fetalis. (healthtap.com)
- The patient presented with a large cystic mass in the thoracic cavity complicated by hydrops fetalis. (elsevier.com)
- Radiofrequency catheter ablation in a haemodynamically compromised premature neonate with hydrops fetalis. (biomedsearch.com)
- Diseases associated with EPHB4 include Hydrops Fetalis, Nonimmune, And/Or Atrial Septal Defect and Hydrops Fetalis . (genecards.org)
- Nonimmune - This is the more typical type of hydrops fetalis. (medicalfoxx.com)
- Hydrops fetalis can develop for a variety of reasons, such as from problems related to Rh sensitization or chromosomal abnormalities. (healthlinkbc.ca)
- Treatment of hydrops depends on the cause. (nyhq.org)
- Hydrops fetalis often results in death of the infant shortly before or after delivery. (medlineplus.gov)
- Human parvovirus B19 infection is known to be one of the causes of hydrops fetalis . (bvsalud.org)