A network of cross-linked hydrophilic macromolecules used in biomedical applications.
Water swollen, rigid, 3-dimensional network of cross-linked, hydrophilic macromolecules, 20-95% water. They are used in paints, printing inks, foodstuffs, pharmaceuticals, and cosmetics. (Grant & Hackh's Chemical Dictionary, 5th ed)
Synthetic or natural materials, other than DRUGS, that are used to replace or repair any body TISSUES or bodily function.
Soft, supple contact lenses made of plastic polymers which interact readily with water molecules. Many types are available, including continuous and extended-wear versions, which are gas-permeable and easily sterilized.
Polymers of ETHYLENE OXIDE and water, and their ethers. They vary in consistency from liquid to solid depending on the molecular weight indicated by a number following the name. They are used as SURFACTANTS, dispersing agents, solvents, ointment and suppository bases, vehicles, and tablet excipients. Some specific groups are NONOXYNOLS, OCTOXYNOLS, and POLOXAMERS.
Generating tissue in vitro for clinical applications, such as replacing wounded tissues or impaired organs. The use of TISSUE SCAFFOLDING enables the generation of complex multi-layered tissues and tissue structures.
Cell growth support structures composed of BIOCOMPATIBLE MATERIALS. They are specially designed solid support matrices for cell attachment in TISSUE ENGINEERING and GUIDED TISSUE REGENERATION uses.
A polymer prepared from polyvinyl acetates by replacement of the acetate groups with hydroxyl groups. It is used as a pharmaceutic aid and ophthalmic lubricant as well as in the manufacture of surface coatings artificial sponges, cosmetics, and other products.
Term used to designate tetrahydroxy aldehydic acids obtained by oxidation of hexose sugars, i.e. glucuronic acid, galacturonic acid, etc. Historically, the name hexuronic acid was originally given to ascorbic acid.
The testing of materials and devices, especially those used for PROSTHESES AND IMPLANTS; SUTURES; TISSUE ADHESIVES; etc., for hardness, strength, durability, safety, efficacy, and biocompatibility.
A sugar acid formed by the oxidation of the C-6 carbon of GLUCOSE. In addition to being a key intermediate metabolite of the uronic acid pathway, glucuronic acid also plays a role in the detoxification of certain drugs and toxins by conjugating with them to form GLUCURONIDES.
A product formed from skin, white connective tissue, or bone COLLAGEN. It is used as a protein food adjuvant, plasma substitute, hemostatic, suspending agent in pharmaceutical preparations, and in the manufacturing of capsules and suppositories.
Salts of alginic acid that are extracted from marine kelp and used to make dental impressions and as absorbent material for surgical dressings.
A broad family of synthetic organosiloxane polymers containing a repeating silicon-oxygen backbone with organic side groups attached via carbon-silicon bonds. Depending on their structure, they are classified as liquids, gels, and elastomers. (From Merck Index, 12th ed)
Hydrophilic contact lenses worn for an extended period or permanently.
A biocompatible, hydrophilic, inert gel that is permeable to tissue fluids. It is used as an embedding medium for microscopy, as a coating for implants and prostheses, for contact lenses, as microspheres in adsorption research, etc.
A nonionic polyoxyethylene-polyoxypropylene block co-polymer with the general formula HO(C2H4O)a(-C3H6O)b(C2H4O)aH. It is available in different grades which vary from liquids to solids. It is used as an emulsifying agent, solubilizing agent, surfactant, and wetting agent for antibiotics. Poloxamer is also used in ointment and suppository bases and as a tablet binder or coater. (Martindale The Extra Pharmacopoeia, 31st ed)
Colorless, odorless crystals that are used extensively in research laboratories for the preparation of polyacrylamide gels for electrophoresis and in organic synthesis, and polymerization. Some of its polymers are used in sewage and wastewater treatment, permanent press fabrics, and as soil conditioning agents.
Microbial, plant, or animal cells which are immobilized by attachment to solid structures, usually a column matrix. A common use of immobilized cells is in biotechnology for the bioconversion of a substrate to a particular product. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)
Polymers of organic acids and alcohols, with ester linkages--usually polyethylene terephthalate; can be cured into hard plastic, films or tapes, or fibers which can be woven into fabrics, meshes or velours.
The study of the deformation and flow of matter, usually liquids or fluids, and of the plastic flow of solids. The concept covers consistency, dilatancy, liquefaction, resistance to flow, shearing, thixotrophy, and VISCOSITY.
Lenses designed to be worn on the front surface of the eyeball. (UMDNS, 1999)
Condition of having pores or open spaces. This often refers to bones, bone implants, or bone cements, but can refer to the porous state of any solid substance.
Small uniformly-sized spherical particles, of micrometer dimensions, frequently labeled with radioisotopes or various reagents acting as tags or markers.
Deacetylated CHITIN, a linear polysaccharide of deacetylated beta-1,4-D-glucosamine. It is used in HYDROGEL and to treat WOUNDS.
Dosage forms of a drug that act over a period of time by controlled-release processes or technology.
Numerical expression indicating the measure of stiffness in a material. It is defined by the ratio of stress in a unit area of substance to the resulting deformation (strain). This allows the behavior of a material under load (such as bone) to be calculated.
Acrylic acids or acrylates which are substituted in the C-2 position with a methyl group.
The properties and processes of materials that affect their behavior under force.
Dressings comprised of a self-adhesive matrix to which hydrophilic absorbent particles are embedded. The particles consist of CELLULOSE derivatives; calcium ALGINATES; PECTINS; or GELS. The utility is based on providing a moist environment for WOUND HEALING.
A natural high-viscosity mucopolysaccharide with alternating beta (1-3) glucuronide and beta (1-4) glucosaminidic bonds. It is found in the UMBILICAL CORD, in VITREOUS BODY and in SYNOVIAL FLUID. A high urinary level is found in PROGERIA.
Methods for maintaining or growing CELLS in vitro.
Submicron-sized fibers with diameters typically between 50 and 500 nanometers. The very small dimension of these fibers can generate a high surface area to volume ratio, which makes them potential candidates for various biomedical and other applications.
Systems for the delivery of drugs to target sites of pharmacological actions. Technologies employed include those concerning drug preparation, route of administration, site targeting, metabolism, and toxicity.
Materials fabricated by BIOMIMETICS techniques, i.e., based on natural processes found in biological systems.
Sterile solutions used to clean and disinfect contact lenses.
Introduction of substances into the body using a needle and syringe.
Forms to which substances are incorporated to improve the delivery and the effectiveness of drugs. Drug carriers are used in drug-delivery systems such as the controlled-release technology to prolong in vivo drug actions, decrease drug metabolism, and reduce drug toxicity. Carriers are also used in designs to increase the effectiveness of drug delivery to the target sites of pharmacological actions. Liposomes, albumin microspheres, soluble synthetic polymers, DNA complexes, protein-drug conjugates, and carrier erythrocytes among others have been employed as biodegradable drug carriers.
Microscopy in which the object is examined directly by an electron beam scanning the specimen point-by-point. The image is constructed by detecting the products of specimen interactions that are projected above the plane of the sample, such as backscattered electrons. Although SCANNING TRANSMISSION ELECTRON MICROSCOPY also scans the specimen point by point with the electron beam, the image is constructed by detecting the electrons, or their interaction products that are transmitted through the sample plane, so that is a form of TRANSMISSION ELECTRON MICROSCOPY.
Compounds formed by the joining of smaller, usually repeating, units linked by covalent bonds. These compounds often form large macromolecules (e.g., BIOPOLYMERS; PLASTICS).
Polymers of silicone that are formed by crosslinking and treatment with amorphous silica to increase strength. They have properties similar to vulcanized natural rubber, in that they stretch under tension, retract rapidly, and fully recover to their original dimensions upon release. They are used in the encapsulation of surgical membranes and implants.
Implants constructed of materials designed to be absorbed by the body without producing an immune response. They are usually composed of plastics and are frequently used in orthopedics and orthodontics.
Bone-marrow-derived, non-hematopoietic cells that support HEMATOPOETIC STEM CELLS. They have also been isolated from other organs and tissues such as UMBILICAL CORD BLOOD, umbilical vein subendothelium, and WHARTON JELLY. These cells are considered to be a source of multipotent stem cells because they include subpopulations of mesenchymal stem cells.
Reagents with two reactive groups, usually at opposite ends of the molecule, that are capable of reacting with and thereby forming bridges between side chains of amino acids in proteins; the locations of naturally reactive areas within proteins can thereby be identified; may also be used for other macromolecules, like glycoproteins, nucleic acids, or other.
The resistance that a gaseous or liquid system offers to flow when it is subjected to shear stress. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
The sodium salt of BENZOIC ACID. It is used as an antifungal preservative in pharmaceutical preparations and foods. It may also be used as a test for liver function.
Substances used to cause adherence of tissue to tissue or tissue to non-tissue surfaces, as for prostheses.
Process by which unwanted microbial, plant or animal materials or organisms accumulate on man-made surfaces.
An interdisciplinary field in materials science, ENGINEERING, and BIOLOGY, studying the use of biological principles for synthesis or fabrication of BIOMIMETIC MATERIALS.
Relating to the size of solids.
Artificial substitutes for body parts and materials inserted into organisms during experimental studies.
Material used for wrapping or binding any part of the body.
The span of viability of a cell characterized by the capacity to perform certain functions such as metabolism, growth, reproduction, some form of responsiveness, and adaptability.
Characteristics or attributes of the outer boundaries of objects, including molecules.
Biological activities and functions of the SKIN.
A group of glucose polymers made by certain bacteria. Dextrans are used therapeutically as plasma volume expanders and anticoagulants. They are also commonly used in biological experimentation and in industry for a wide variety of purposes.
Poly-2-methylpropenoic acids. Used in the manufacture of methacrylate resins and plastics in the form of pellets and granules, as absorbent for biological materials and as filters; also as biological membranes and as hydrogens. Synonyms: methylacrylate polymer; poly(methylacrylate); acrylic acid methyl ester polymer.
A technique for maintaining or growing TISSUE in vitro, usually by DIFFUSION, perifusion, or PERFUSION. The tissue is cultured directly after removal from the host without being dispersed for cell culture.

Lysozyme sorption in hydrogel contact lenses. (1/453)

PURPOSE: To examine the processes involved in formation of protein deposits on hydrogel contact lenses. METHODS: The adsorption and/or penetration of lysozyme on or into three types of contact lenses, etafilcon A, vifilcon A, and tefilcon, were investigated in vitro using a radiolabel-tracer technique, x-ray photoelectron spectroscopy, and laser scanning confocal microscopy. RESULTS: Binding of lysozyme to high-water-content, ionic contact lenses (etafilcon A and vifilcon A) was dominated by a penetration process. The extent of this penetration was a function of charge density of the lenses, so that there was a higher degree of penetration of lysozyme in etafilcon A than in vifilcon A lenses. In contrast, the binding of lysozyme to tefilcon lenses was a surface adsorption process. The adsorption and desorption kinetics showed similar trends to those found in human serum albumin (HSA) adsorption on lens surfaces. However, the extent of lysozyme adsorption on tefilcon is much higher than HSA adsorption, probably because of the self-association of lysozyme on the tefilcon lens surface. Furthermore, either penetration or adsorption of lysozyme involved reversible and irreversible processes and were both time dependent. CONCLUSIONS: Binding of lysozyme to hydrogel lenses involves surface adsorption or matrix penetration. These processes may be reversible or irreversible. The properties of the lens materials, such as charge density (ionicity) and porosity (water content) of the lenses, determine the type and rates of these processes.  (+info)

Sympathetic swelling response of the control eye to soft lenses in the other eye. (2/453)

PURPOSE: To compare central corneal swelling and light scatter after 8 hours of sleep in eyes wearing high- and low-Dk hydrogel lenses and to the contralateral control eyes. METHODS: Twenty neophyte subjects wore a Lotrafilcon A (Dk, 140; Ciba Vision, Duluth GA) silicone hydrogel lens and an Etafilcon A (Dk, 18; Acuvue; Vistakon, Jacksonville, FL) 58% water content hydrogel lens of similar center thickness in random order in the right eye only, for overnight 8-hour periods. The contralateral nonwearing left eyes served as controls. Central corneal thickness was measured using an optical pachometer and light scatter using a Van den Berg stray-light meter before lens insertion, after lens removal on waking, and every 20 minutes for the next 3 hours. RESULTS: Central corneal swelling induced by the Etafilcon A lens on eye opening was significantly higher than with the Lotrafilcon A lens (8.66%+/-2.84% versus 2.71%+/-1.91%; P<0.00001). Light scatter induced by the Etafilcon A lens on eye opening was significantly higher than with the Lotrafilcon A lens (46.09+/-5.62 versus 42.78+/-6.07 Van den Berg units, P = 0.0078). The swelling of the control eyes paired with the Etafilcon A lens-wearing eyes was also slightly but significantly higher than that of the control eyes paired with the Lotrafilcon A lens-wearing eyes (2.34%+/-1.26% versus 1.44%+/-0.91%; P = 0.0002). Light-scatter measurements were not significantly different between control sets of eyes but showed the same trend. CONCLUSIONS: In neophyte subjects, corneal swelling of the contralateral control eyes appears to be influenced by the swelling of the fellow lens-wearing eyes-that is, the swelling of the contralateral control eye was significantly lower when there was less swelling of the fellow eye wearing the high-Dk lens. Although there was no statistically significant difference in light-scatter measurements between the control sets of eyes, a trend similar to the corneal swelling results was observed, which could be used to support the suggestion that this may be a sympathetic physiological response rather than an unusual sampling coincidence.  (+info)

Orally administered, insulin-loaded amidated pectin hydrogel beads sustain plasma concentrations of insulin in streptozotocin-diabetic rats. (3/453)

We report successful oral administration of insulin entrapped in amidated pectin hydrogel beads in streptozotocin (STZ)-diabetic rats, with a concomitant reduction in plasma glucose concentration. The pectin-insulin (PI) beads were prepared by the gelation of humilin-pectin solutions in the presence of calcium. Separate groups of STZ-diabetic rats were orally administered two PI beads (30 micrograms insulin) once or twice daily or three beads (46 micrograms) once daily for 2 weeks. Control non-diabetic and STZ-diabetic rats were orally administered pectin hydrogel drug-free beads. By comparison with control non-diabetic rats, untreated STZ-diabetic rats exhibited significantly low plasma insulin concentration (0.32+/-0. 03 ng/ml, n=6, compared with 2.60+/-0.44 ng/ml in controls, n=6) and increased plasma glucose concentrations (25.84+/-1.44 mmol/l compared with 10.72+/- 0.52 mmol/l in controls). Administration of two PI beads twice daily (60 micrograms active insulin) or three beads (46 micrograms) once a day to STZ-diabetic rats increased plasma insulin concentrations (0.89+/-0.09 ng/ml and 1.85+/- 0.26 ng/ml, respectively), with a concomitant reduction in plasma glucose concentration (15.45+/-1.63 mmol/l and 10.56+/-0.26 mmol/l, respectively). However, a single dose of PI beads (30 micrograms) did not affect plasma insulin concentrations, although plasma glucose concentrations (17.82+/-2.98 mmol/l) were significantly reduced compared with those in untreated STZ-diabetic rats. Pharmacokinetic parameters in STZ-diabetic rats show that the orally administered PI beads (30 micrograms insulin) were more effective in sustaining plasma insulin concentrations than was s.c. insulin (30 micrograms). The data from this study suggest that this insulin-loaded amidated pectin hydrogel bead formulation not only produces sustained release of insulin, but may also reduce plasma glucose concentration in diabetes mellitus.  (+info)

Biomechanical and histological evaluation of hydrogel implants in articular cartilage. (4/453)

We evaluated the mechanical behavior of the repaired surfaces of defective articular cartilage in the intercondylar region of the rat femur after a hydrogel graft implant. The results were compared to those for the adjacent normal articular cartilage and for control surfaces where the defects remained empty. Hydrogel synthesized by blending poly(2-hydroxyethyl methacrylate) and poly(methyl methacrylate-co-acrylic acid) was implanted in male Wistar rats. The animals were divided into five groups with postoperative follow-up periods of 3, 5, 8, 12 and 16 weeks. Indentation tests were performed on the neoformed surfaces in the knee joint (with or without a hydrogel implant) and on adjacent articular cartilage in order to assess the mechanical properties of the newly formed surface. Kruskal-Wallis analysis indicated that the mechanical behavior of the neoformed surfaces was significantly different from that of normal cartilage. Histological analysis of the repaired defects showed that the hydrogel implant filled the defect with no signs of inflammation as it was well anchored to the surrounding tissues, resulting in a newly formed articular surface. In the case of empty control defects, osseous tissue grew inside the defects and fibrous tissue formed on the articular surface of the defects. The repaired surface of the hydrogel implant was more compliant than normal articular cartilage throughout the 16 weeks following the operation, whereas the fibrous tissue that formed postoperatively over the empty defect was stiffer than normal articular cartilage after 5 weeks. This stiffness started to decrease 16 weeks after the operation, probably due to tissue degeneration. Thus, from the biomechanical and histological point of view, the hydrogel implant improved the articular surface repair.  (+info)

Evaluation of properties microcrystalline chitosan as a drug carrier. Part 1. In vitro release of diclofenac from mictocrystalline chitosan hydrogel. (5/453)

The influence of microcrystalline chitosan hydrogel, alone (MCCh) as well as in combination with methylcellulose (MC) or Carbopol (CP), on the release of diclofenac free acid (DA) and its salt (DS) was studied in vitro. Commercial Olfen gel (Mepha Ltd., Switzerland) was applied as a reference preparation. The influence of hydrophilizing agents (1,2-propylene glycol and glycerol) and methycellulose hydrogel on the rheological properties of the vehicle and on the release of drug from modified MCCh hydrogel was studied. The quantity of the released substance was determined by UV-spectroscopy. The results confirmed that release was dependent on the chemical character of the drug and on the type of vehicle. The process of diclofenac release from MCCh hydrogels as well as from Carbopol hydrogels runs in two phases. The first phase is characterised by rapid release whereas in the second phase the release is much slower. The most suitable basis for diclofenac is microcrystalline chitosan hydrogel with addition glycerol, 1,2-propylene glycol, and methylcellulose hydrogel.  (+info)

Improvement of transdermal permeation of captopril by iontophoresis. (6/453)

AIM: The feasibility of iontophoresis on the transdermal delivery of captopril was studied. METHODS: Iontophoresis was employed for enhancing transdermal transport of captopril through rat skin in vitro and in vivo. RESULTS: It was demonstrated that the iontophoresis-induced flux of captopril was affected by various factors such as pH, ionic concentration, and the concentration of captopril in donor compartments as well as the applied electric current intensity. Electric current could induce several-fold increase in captopril flux with hydrogel. Skin permeation study in vivo in rats demonstrated that iontophoresis could effectively promote the transdermal transport of captopril without significant skin irritation. Captopril concentration in plasma reached plateau (approximately 0.9 microgram/mL) at 1 h after current application and was maintained at the same level during the experiment. On the contrary, captopril could not be detected in plasma when the current was not applied. No obvious skin irritation was observed after 9-h continuous iontophoresis. CONCLUSION: Transdermal delivery of captopril can be effectively improved by iontopophoresis.  (+info)

Imaging of hydrogel episcleral buckle fragmentation as a late complication after retinal reattachment surgery. (7/453)

Hydrogel encircling bands were introduced in the early 1980s as a product that was superior to bands composed of silicone rubber or silicone sponge for the surgical treatment of retinal detachment. Late complications consisting of orbital swelling and diplopia requiring band removal began to be reported in the early 1990s. Pathologic studies of these expanded fragments of hydrogel material after removal showed in vivo hydrolysis with foreign body reaction and dystrophic calcification. We report the imaging findings in five patients in whom this late complication developed. Hydrogel fragmentation has a characteristic imaging appearance consisting of a circumferential orbital mass associated with rim enhancement. This appearance should prompt inquiries regarding previous scleral buckle procedures with hydrogel bands. Familiarity with this appearance will avoid misinterpretation and unwarranted biopsy before band removal.  (+info)

Cell traction forces on soft biomaterials. I. Microrheology of type I collagen gels. (8/453)

A laser-trap microrheometry technique was used to determine the local shear moduli of Type I collagen gels. Embedded 2.1 microm polystyrene latex particles were displaced 10-100 nm using a near-infrared laser trap with a trap constant of 0.0001 N/m. The trap was oscillated transversely +/- 200 nm using a refractive glass plate mounted on a galvanometric scanner. The displacement of the microspheres was in phase with the movement of the laser trap at frequencies less than 1 rad/s, indicating that at least locally, the gels behaved as elastic media. The local shear modulus was measured at various positions throughout the gel, and, for gels at 2.3 mg/mL and 37 degrees C, values ranged from G = 3 to 80 Pa. The average shear modulus G = 55 Pa, which compares well with measurements from parallel plate rheometry.  (+info)

A method of fabricating hydrogel particles within liposomes, which entails: a) encapsulating an effective amount of each of one or more hydrogel substances and one or more release agents in liposomes in a liquid medium, b) removing any unencapsulated hydrogel substances and release agents from the liquid medium, c) adding initiator to the liquid medium and into the liposomes, thereby initiating reaction of the one or more hydrogel substances, whereby hydrogel particles are formed in the liposomes, and d) removing any extra-liposomal initiator from the medium.
TY - JOUR. T1 - Enzyme-triggered cell attachment to hydrogel surfaces. AU - Todd, Simon J.. AU - Farrar, David. AU - Gough, Julie E.. AU - Ulijn, Rein V.. PY - 2007. Y1 - 2007. N2 - We describe enzyme-triggered activation of cell adhesion ligands tethered to a hydrogel surface to direct the attachment of osteoblast cells on demand.. AB - We describe enzyme-triggered activation of cell adhesion ligands tethered to a hydrogel surface to direct the attachment of osteoblast cells on demand.. KW - enzyme-triggered. KW - cell attachment KW - hydrogel surfaces. U2 - 10.1039/b618256a. DO - 10.1039/b618256a. M3 - Article. VL - 3. SP - 547. EP - 550. JO - Soft Matter. JF - Soft Matter. SN - 1744-683X. IS - 5. ER - ...
Development and optimization of a dual-photoinitiator, emulsion-based technique for rapid generation of cell-laden hydrogel microspheres.
Emerging medical technologies for effective and lasting repair of articular cartilage include delivery of cells or cell-seeded scaffolds to a defect site to initiate de novo tissue regeneration. Biocompatible scaffolds assist in providing a template for cell distribution and extracellular matrix accumulation in a three-dimensional geometry. In these studies, a self-assembling peptide hydrogel is evaluated as a potential scaffold for cartilage repair using a model bovine cell source. A seeding technique is developed for 3-D encapsulation of chondrocytes in a peptide hydrogel. The chondrocyte-seeded peptide hydrogel was then evaluated cellular activities in vitro under standard culture conditions and also when subjected to dynamic compression. During 4 weeks of culture in vitro, chondrocytes seeded within the peptide hydrogel retained their morphology and developed a cartilage-like ECM rich in proteoglycans and type II collagen, indicative of a stable chondrocyte phenotype. Time dependent ...
Hydrogel particles, also known as microgels, consist of cross-linked three-dimensional water-soluble polymer networks. They play an essential role in loading and delivering active ingredients in medicine, cosmetics, and foods. Despite their excellent biocompatibility as well as structural diversity, much wider applications are limited due mainly to their intrinsically loose network nature. This study introduces a practical and straightforward method that enables fabrication of hydrogel microparticles layered with a mechanically robust hybrid thin shell. Basically highly monodisperse hydrogel microparticles were produced in microcapillary devices. Then, their surface was coated with alternate polyelectrolyte layers through the layer-by-layer deposition. Finally a thin silica layer was again formed by reduction of silicate on the amino-functionalized polyelectrolyte layer. We have figured out that these hybrid hydrogel microparticles showed controlled loading and releasing behaviors for ...
Synthetic hydrogel scaffold is an effective vehicle for delivery of INFUSE (rhBMP2) to critical-sized calvaria bone defects in rats Journal Article ...
0118] In an aspect of this embodiment, a hydrogel formulation comprises a gel phase including hydrogel particles having a particle size from about 5 μm2 to about 1000 μm2 in cross-sectional area. In aspects of this embodiment, a hydrogel formulation comprises a gel phase including hydrogel particles having a mean particle size of, e.g., about 5 μm2, about 10 μm2, about 15 μm2, about 20 μm2, about 25 μm2, about 30 μm2, about 35 μm2, about 40 μm2, about 45 μm2, about 50 μm2, about 60 μm2, about 70 μm2, about 80 μm2, about 90 μm2, about 100 μm2, about 200 μm2, about 300 μm2, about 400 μm2, about 500 μm2, about 600 μm2, about 700 μm2, about 800 μm2, about 900 μm2, or about 1000 μm2 in cross-sectional area. In other aspects of the embodiment, a hydrogel formulation comprises a gel phase including hydrogel particles having a mean particle size of, e.g., at least 5 μm2, at least 10 μm2, at least 15 μm2, at least 20 μm2, at least 25 μm2, at least 30 μm2, at least 35 μm2, ...
The combination of hydrogel and nitrogen may favor the expression of grain productivity of wheat. The goal of the study was to analyze the nitrogen utilization efficiency in wheat through the hydrogel biopolymer, defining the optimal dose of hydrogel and nitrogen combination at the maximum grain productivity, in succession systems of high and reduced N-residual release. The study was carried out in 2014 and 2015, in randomized block design with four replicates in a 4 x 4 factorial, for hydrogel doses (0, 30, 60 and 120 kg ha-1), added in the furrow along the seed and fertilizer-N doses (0, 30, 60 and 120 kg ha-1), applied in the stage of third leaf expanded, respectively, in the soy/wheat and corn/wheat systems. The hydrogel biopolymer increases the efficiency of nitrogen use in grain productivity of wheat in succession systems. The ideal combination of hydrogel and nitrogen at the maximum grain productivity is 58 and 93 kg ha-1, respectively, in the soybean/wheat systems and 44 and 115 kg ha-1, ...
This synthetic hydrogel can be used to culture human intestinal organoids and may one day help provide a treatment for intestinal conditions.
Congratulations to Jiwei Cui et al from the University of Melbourne and the Laboratory for Mechanics of Materials and Nanostructureswho recently published Super soft hydrogel particles with tunable elasticity in a microfluidic blood capillary model in Advanced Materials. The paper explores super-soft PEG hydrogel particles with tunable elasticity which are prepared via a mesoporous silica templating method. The deformability behavior of these particles, in a microfluidic blood capillary model, can be tailored to be similar to that of human red blood cells. These results provide a new platform for the design and development of soft hydrogel particles for investigating bio-nano interactions. (see figure 1) Congratulations to MCN Staff Member, Fatima Eftekhari and Technology Fellows Wenlong Cheng and Qiaoliang Bao from Monash University who recently published Giant Plasmene Nanosheets, Nanoribbons, and Origami in ACS Nano. The paper introduces Plasmene- in analogy to graphene-as free-standing, ...
The present disclosure relates to a hydrogel composition and methods of using the same. The hydrogel composition may include precursors that react with each other upon contact as well as precursors that react upon contact with an initiator. In embodiments, the resulting hydrogels may have varying levels of crosslinking with both denser and less dense regions.
Enhancing neurite outgrowth from primary neurones and neural stem cells using thermoresponsive hydrogel scaffolds for the repair of spinal cord injury. Journal Articles Refereed ...
Learn more about stem cells by reading Stem Cell-Based Bone Tissue Engineering with a Hydrogel Scaffold Shows Promise for Bone Repair on the Stemodontics® website.
Group led by Dr. Avinash Bajaj from Regional Centre for Biotechnology designed a low molecular weight hydrogel that can maintain sustained and sequential release of combination of drugs and inhibit the tumor progression in murine models. Using the bioconjugation strategies and biocompatible bile acid and peptide scaffolds, Dr. Bajajs group engineered a biocompatible and biodegradable hydrogel. They then entrapped a combination of anti-proliferative (doxorubicin), anti-angiogenic (combretastatin) and anti-inflammatory (dexamethasone) drugs in the hydrogel. Local implantation of the hydrogel reduces the tumor growth kinetics significantly and enhances the median survival. In collaboration with Dr. Ujjaini Dasgupta group at Amity University, Haryana, they have deciphered the in-depth mechanism and found that hydrogel-mediated delivery of combination of drugs alters the sphingolipid metabolism and helps in combating drug resistance.. More details about this research can been read ...
TY - JOUR. T1 - Controlling the Surface Chemistry of a Hydrogel for Spatially Defined Cell Adhesion. AU - Chen, Jeffrey W.. AU - Lim, Kelly. AU - Bandini, Stephen B.. AU - Harris, Greg M.. AU - Spechler, Joshua A.. AU - Arnold, Craig B.. AU - Fardel, Romain. AU - Schwarzbauer, Jean E.. AU - Schwartz, Jeffrey. N1 - Funding Information: The authors thank the New Jersey Commission on Spinal Cord Research (CSCR15IRG002), the National Science Foundation (DMR-1420541), and a New Ideas in the Natural Sciences award from the Princeton Dean for Research for support of this research.. PY - 2019/5/1. Y1 - 2019/5/1. N2 - A two-step synthesis is described for activating the surface of a fully hydrated hydrogel that is of interest as a possible scaffold for neural regeneration devices. The first step exploits the water content of the hydrogel and the hydrophobicity of the reaction solvent to create a thin oxide layer on the hydrogel surface using a common titanium or zirconium alkoxide. This layer serves as a ...
Pages that link to Regulating Volume Transitions of Highly Responsive Hydrogel Scaffolds by Adjusting the Network Properties of Microgel Building Block Colloids ...
TY - JOUR. T1 - Poly-l-Lactic Acid Nanofiber-Polyamidoamine Hydrogel Composites: Preparation, Properties, and Preliminary Evaluation as Scaffolds for Human Pluripotent Stem Cell Culturing. AU - Mauro, Nicolò. AU - Gualandi, Chiara. AU - Visai, Livia. AU - Bloise, Nora. AU - Mauro, Nicolò. AU - Gherardi, Matteo. AU - Laurita, Romolo. AU - Liguori, Anna. AU - Focarete, Maria Letizia. AU - Sampaolesi, Maurilio. AU - Colombo, Vittorio. AU - Ranucci, Elisabetta. AU - Ferruti, Paolo. AU - Manfredi, Amedea. PY - 2016. Y1 - 2016. N2 - Electrospun poly-l-lactic acid (PLLA) nanofiber mats carrying surface amine groups, previously introduced by nitrogen atmospheric pressure nonequilibrium plasma, are embedded into aqueous solutions of oligomeric acrylamide-end capped AGMA1, a biocompatible polyamidoamine with arg-gly-asp (RGD)-reminiscent repeating units. The resultant mixture is finally cured giving PLLA-AGMA1 hydrogel composites that absorb large amounts of water and, in the swollen state, are ...
Corneal endothelial cells (CECs) have limited proliferation ability leading to corneal endothelium (CE) dysfunction and eventually vision loss when cell number decreases below a critical level. Although transplantation is the main treatment method, donor shortage problem is a major bottleneck. The transplantation of in vitro developed endothelial cells with desirable density is a promising idea. Designing cell substrates that mimic the native CE microenvironment is a substantial step to achieve this goal. In the presented study, we prepared polyacrylamide (PA) cell substrates that have a microfabricated topography inspired by the dimensions of CECs. Hydrogel surfaces were prepared via two different designs with small and large patterns. Small patterned hydrogels have physiologically relevant hexagon densities (similar to 2000 hexagons/mm(2)), whereas large patterned hydrogels have sparsely populated hexagons (similar to 400 hexagons/mm(2)). These substrates have similar elastic modulus of native ...
Weve all had booster shots at some point in our lives. You know, you get an immunization injection, then at some point in the future you have to have another round to make sure you have the proper level of immunity.. This can be a major pain (pardon the pun) for many of us. When I received my Hepatitis B vaccine while in dental school, the proper protocol was for a 3 shot series.. Now, in dental school, it was easy. The injections were given by the oral surgery department and I was notified when to return for my next round. However, in the real world this can mean more trips to a doctors office for these follow up visits. This can result in lost work time, taking kids out of school, etc. Not to mention the fact that you actually have to get the injections to ensure immunity. Lots of people either forget or are scared and just dont get them.. Now comes word of a way around these booster injections.. The idea is to place a booster amount in a small pea sized hydrogel capsule that is injected ...
The product is a synthetic hydrogel consisting primarily of water and iodinated cross-linked polyethylene glycol. Injectable through a fine needle, small hydrogel injections are clearly visible in the lung, breast, prostate and other tissues. The hydrogel remains stable and visible in tissue for three months, long enough for radiotherapy, and then is absorbed and cleared from the body, the company said.. ...
Travoprost was encapsulated in various formulations of polylactide microparticles (PM), which were dry blended and suspended in a multi-arm polyethylene glycol (PEG) precursor solution conjugated with fluorescein and injected into small bore tubing prior to cross-linking. The travoprost in the PM/hydrogel matrix was dried in tubing and cut into plugs. Drug release rate from the respective formulations was assessed in PBS at pH 7.4 at 37 C until complete dissolution. The 3-month formulation was evaluated for plug visualization through the tissue in a canine model under illumination with a blue light and yellow filter.. ...
Biomaterial-based regenerative approaches would allow for cost-effective off-the-shelf solution for the treatment of wounds. Hyaluronan (HA)-based hydrogel is one attractive biomaterial candidate because it is involved in natural healing processes, including inflammation, granulation, and reepi-thelialization. Herein, dynamic metal-ligand coordination bonds are used to fabricate moldable supramolecular HA hydrogels with self-healing properties. To achieve reversible crosslinking of HA chains, the biopolymer is modified with pendant bisphosphonate (BP) ligands using carbodiimide coupling and chemoselective click reactions. Hydrogel is formed immediately after simple addition of silver (Ag+) ions to the solution of HA containing BP groups (HA-BP). Compared with previous HA-based wound healing hydrogels, the HA-BP·Ag+ hydrogel is highly suitable for clinical use as it can fill irregularly shaped wound defects without the need for premolding. The HA-BP·Ag+ hydrogel shows antimicrobial ...
China Hot Selling Transparent Debridement Hydrogel, Find details about China Ulcer Wound Dressing, Hydrogel for Burn Wound from Hot Selling Transparent Debridement Hydrogel - Huizhou Foryou Medical Devices Co., Ltd.
ROYSTON, England /ePRNews/ Particle Works - the nano- and microstructured material specialist - has developed a range of alginate and agarose hydrogel beads designed to enable three dimensional cell culture growth. This bead-based…
Objectives: Direct pulp capping is a treatment for preserving the vital pulp. However, a satisfactory material for caries-exposed inflamed pulp in permanent teeth is not currently available. Thus, a biologically-based material that promotes the continued formation of a new dentin-pulp complex is needed. A hydrogel drug delivery vehicle is a promising material, however its cytotoxicity has barely been explored. The aim of this study is to evaluate the cytotoxicity of a hydrogel drug delivery vehicle and its components in a cell culture system in vitro. Methods: The hydrogel solution was prepared by mixing poly(ethylene glycol)maleate-citrate (45% w/v)[PEGMC], acrylic acid (5% w/v)[AA], 2,2-Azobis(2-methylpropionamidine) dihydrochloride photoinitiator (0.1% w/v)[AAPH], and deionized water. Various concentrations of the hydrogel and its components were prepared in the cell culture medium. L929 cells were seeded into 96-well plates at 3x103 cells/well and cultured with each concentration of the ...
The Global Hydrogel market 2017 report is a comprehensive and professional document to deliver the market research data that is relevant for the newly established players in the market. The major leading industry players over the globe are focused in the report with the information including company profiles, specifications and product picture, market share, contact information and sales.. The report has been built by a highly seasoned analyst team and data experts, with containing the graphs besides qualitative analyses and an array of tables. As the report starts with a discussion on the Hydrogel market current state, it goes to the dynamics that affect each segment within it.. The report also avails the detailed theory about the Hydrogel market key segments and growth prospects. The report study presents a competitive landscape for the market that profiles the outstanding market players.. With the help of key inputs from industry experts, the research study of Hydrogel is composed. ...
Taking medication often comes with side effects which range in severity which may even deter people from seeking treatment. Accordingly, there is a need for improved efficiency in drug delivery which can be achieved with the use of a nanoparticle drug delivery system. In order to manufacture drug delivery hydrogel particles at a nanoscale, the behavior of the system must first be understood fundamentally. This study focused on quantifying the amount of a drug, chosen to be DL-propranolol hydrochloride, that diffuses into a poly(n-isopropylacrylamide) (PNIPAm) hydrogel at equilibrium. Three gels were synthesized and soaked in a solution containing DL-propranolol hydrochloride for 14 days, which was found to be the amount of time needed for the drug to reach equilibrium (complete diffusion). After this time period, the gels were then sliced into disks in order for the drug to be extracted. Using UV-visible spectroscopy, the concentration of drug in each disk was analyzed. This data, along with the ...
Ranganath, S.H.,Yang, A.,Chan, Y.Y.,Huang, J.,Krantz, W.B.,Wang, C.-H. (2008). Implantable hydrogel beads entrapping PLGA-paclitaxel microspheres: Exploring the effects of near-zero-order drug release for intracranial chemotherapy. AIChE Annual Meeting, Conference Proceedings : -. [email protected] Repository ...
Due to our aging population, an increase in proximal femur fractures can be expected, which is associated with impaired activities of daily living and a high risk of mortality. These patients are also at a high risk to suffer a secondary osteoporosis-related fracture on the contralateral hip. In this context, growth factors could open the field for regenerative approaches, as it is known that, i.e., the growth factor BMP-7 (bone morphogenetic protein 7) is a potent stimulator of osteogenesis. Local prophylactic augmentation of the proximal femur with a BMP-7 loaded thermoresponsive hydrogel during index surgery of an osteoporotic fracture could be suitable to reduce the risk of further osteoporosis-associated secondary fractures. The present study therefore aims to test the hypothesis if a BMP-7 augmented hydrogel is an applicable carrier for the augmentation of non-fractured proximal femurs. Furthermore, it needs to be shown that the minimally invasive injection of a hydrogel into the mouse femur is
In a new study in pigs, University of California, San Diego bioengineers have shown that a new injectable hydrogel can repair damage from heart attacks,...
TY - JOUR. T1 - Pharmacokinetic and pharmacodynamic evaluation of a novel in situ forming poly(ethylene glycol)-based hydrogel for the controlled delivery of the camptothecins. AU - Lalloo, Anita. AU - Chao, Piyun. AU - Hu, Peidi. AU - Stein, Stanley. AU - Sinko, Patrick J.. PY - 2006/5/30. Y1 - 2006/5/30. N2 - Inadequate drug delivery, due to problems associated with achieving constant therapeutic blood levels, has hampered the use of anticancer agents of the camptothecin (CPT) class. The objective of the current studies was to develop a depot delivery system for the water-soluble analog of CPT, topotecan (TPT). In this study, a 2-phase drug depot consisting of TPT-loaded liposomes entrapped in a poly(ethylene glycol) hydrogel was designed. Physically entrapped unaltered TPT displayed a rapid release rate from the hydrogel. Controlled release was demonstrated in vitro and in vivo from the 2-phase system with constant blood levels being achieved for several days in rats. Cytotoxicity and ...
Luchini A, Longo C, Espina V, Petricoin EF III and Liotta LA, Nanoparticle Technology: Addressing the fundamental roadblocks to protein biomarker discovery, Journal of Materials Chemistry, in press. Longo C, Patanarut A, Bishop B, Zhou W, Ross MM, Espina VE, Pellacani G, Petricoin EF III, Liotta LA, Luchini A, Core-Shell Hydrogel Particles Harvest, Concentrate and Preserve Labile Low Abundance Biomarkers, PLoS ONE, (2009), Volume 4, Issue 3, e4763.. Fredolini C, Meani F, Reeder KA, Rucker S, Patanarut A, Botterell PJ, Bishop B, Longo C, Espina V, Petricoin, EF III, Liotta LA, and Luchini A. Concentration and Preservation of Very Low Abundance Biomarkers in Urine, such as Human Growth Hormone (hGH), by Cibacron Blue F3G-A Loaded Hydrogel Particles Nano Research, (2008) 1: 502 518.. Luchini A, Long DP, Vaisman I, Petricoin EF, Geho D, Liotta LA. Phosphorylation-induced conformational change alters electron transport in peptide molecular junctions, Research Letters Nanotechnology, Volume 2008 ...
VISHWA HYDROGELS PVT LTD - Exporter, Manufacturer & Supplier of Agricultural Hydrogel, Vaaridhar Pusa Hydrogel based in Gurgaon, Haryana, India.
Hydrogel® Mold Compound is an alginate-based white powder that, after mixing with water, cures in 5 minutes to a moist, rubbery material. Use Hydrogel® to make quick, single-use molds, especially when skin contact is required. Hydrogel is ideal when making molds of the face, hands, feet, torso or other external parts of the human body.Hydrogel® can also be used for taxidermy molds and for mold making applications where a delicate or valuable original cannot be molded in polyurethane or silicone liquid rubbers. Plaster, wax, and EasyFlo 60 Liquid Plastic can be cast into Hydrogel molds.Use Hydrogel® Retarder to extend the working time of Hydrogel®.Product FeaturesNon-toxic - safe for exterior body contactEasy to use - Add water, mix and applyGood reproduction of fine detailFast demold timeVariable working time with addition of Retarder HGLow cost View buying information for Hydrogel® Mold Compound here.
Summary of Facts and Submissions. I. The appeal is from the decision of the examining division posted 10 March 2000 refusing the European patent application 97. 919 017.0.. II. The decision was taken on the basis of an amended set of claims. Claim 1 thereof has the following wording (amendments made during the examination appear in bold):. 1. An aqueous composition comprising:. (a) 40-95% by weight of an aqueous solution containing 5-50% surfactant and having a viscosity greater than 300 centipoises and less than 1500 centipoises; and. (b) 5% to 60% by wt. of a hydrogel composition comprising:. (i) 0.1 to 30% by wt. hydrogel composition of at least one polymer soluble in water which polymer is insolubilized when placed in the aqueous solution of item (a);. (ii) 0.2 to 30% by wt. hydrogel composition of a polymer soluble in water, and soluble or dispersible in the aqueous solution of item (a); and. (iii) 1.0 to 60% water insoluble benefit agent entrapped in a network formed by (i) and ...
M89281, Image, IMAGE I MASK hydrating hydrogel sheet mask (retail box of 5), This hydrogel mask delivers instant hydration to skin that is dry, dull or depleted. Cooling and soothing, it refreshes and revives thirsty skin with mineral-rich waters and hyaluronic acid. A blend of amino acids, aloe vera and antioxidant extracts leave skin radiant and glowing. Newly improved hydrogel design offers a better grip and shape to fit every face. The perfect portable addition to every IMAGE Skincare regimen. , HKTVmall The Largest HK Shopping Platform
Glioblastoma (GBM) invasion and migration are key biological behaviors leading to refractoriness to current therapies and infiltration into the non‑tumor brain parenchyma. GBM cell migration is strongly dependent on tumor architecture in vivo, which is absent in traditional two‑dimensional (2D) monolayer culture. The present study applied a three‑dimensional (3D) hydrogel model to rebuild the tumor architecture in vitro. Treatment with NSC23766, a specific inhibitor of Ras‑related C3 botulinum toxin substrate 1 (Rac1), inhibited the mesenchymal invasiveness however triggered the amoeboid motility called mesenchymal‑amoeboid transition (MAT). Notably, NSC23766 stimulated U87 GBM cell migration in the 3D hydrogel. However, this compound inhibited cell motility in 2D monolayer culture without tumor architecture for MAT, suggesting the advantage of 3D hydrogel to investigate tumor cell invasion. Due to the inverse interaction of Rac1 and Ras homolog family member A (RhoA) signaling in the ...
In this paper, inhomogeneous deformation of a temperature-sensitive hydrogel has been studied and analyzed under arbitrary geometric and boundary conditions. We present the governing equations and equilibrium conditions of an isothermal process based on the monophase gel field theory of hydrogel via a variational approach. We have adopted and implemented an explicit form of energy for temperature-sensitive hydrogel in a three-dimensional finite element method (FEM) using a user-supply subroutine in ABAQUS. For verification purpose, a few numerical results obtained by the proposed approach are compared with existing experimental data and analytical solutions. They are all in good agreement. We also provide several examples to show the possible applications of the proposed method to explain various complex phenomena, including the bifurcation, buckling of membrane, buckling of thin film on compliant substrate and the opening and closure of flowers. © 2013 Elsevier Ltd. All rights reserved ...
Free Shipping on most orders over $60. Great Low Price. Vetericyn Plus Antimicrobial HydroGel is a thicker, gel form of the original Vetericyn Wound & Infection Treatment. HydroGel clings to uneven surfaces to stay in place longer before evaporating. Vetericyn Plus Antimicrobial HydroGel cleans, treats and heals wounds and infections without harming healthy tissue and effectively kills antibiotic-resistant strains of bacteria, fungi, viruses and spores. Use Vetericyn Plus Antimicrobial Hydro
Download FINN HydroGel Additive System Specification Sheet on Agriculture XPRT. FINN HydroGel B is a polymer that is able to store water and nutrients up to 500% its own size and weight. Once HydroGel B releases its stored moisture and nutrients to t...
Hydrogel Gel Tahan Lama Untuk Lelaki BAGAIMANA HYDROGEL BOLEH MENJADI BEGITU ..HEBAT? Beginilah caranya bagaimana HYDROGEL bertindak PRESTASI YANG MEMBANGGAK
The Global Hydrogel Market Research Report 2017is a professional and in-depth study on the current state of the Hydrogel industry. In a word, This report studies Hydrogel in Global market, especially in North America, Europe, China, Japan, Southeast Asia and India, focuses on top manufacturers in global market, with capacity, production, price, revenue and market share for each manufacturer. Key companies included in this research are 3M, Conva Tec Inc., Derma Sciences, Smith&Nephew United, Axelgaard, Coloplast, Paul Hartmann, Covidien, NIPRO PATCH, Ashland, ESI BIO, Ambu, KRUUSE, Johnson & Johnson Services Inc., BSN Medical GmbH, Medico Electrodes International Ltd., The Cooper Companies, Inc., H.B. Fuller Company, Altergon Italia Srl, R&D Medical Products Inc., Spes Medica Srl., Katecho Inc., Takiron Co. Ltd., Sekisui Plastics Co. Ltd. and Alliqua Biomedical Inc... Browse complete report @ http://www.reportsweb.com/global-hydrogel-market-research-report-2017. Market Segment by Region, this ...
The related Agricultural Hydrogel page,you can find more similar Agricultural Hydrogel from SOCO,china Agricultural Hydrogel manufacturer,We provide you excellent products buy services.
Two complementary β-sheet-forming decapeptides have been created that form binary self-repairing hydrogels upon combination of the respective free-flowing peptide solutions at pH 7 and ,0.2 wt %. The component peptides showed little structure separately but formed extended β-sheet fibres upon mixing, which became entangled to produce stiff hydrogels. Microscopy revealed two major structures; thin fibrils with a twisted or helical appearance and with widths comparable to the predicted lengths of the peptides within a β-sheet, and thicker, longer, interwoven fibres that appear to comprise laterally-packed fibrils. A range of gel stiffnesses (G from 0.05 to 100 kPa) could be attained in this system by altering the assembly conditions, stiffnesses that covered the rheological properties desirable for cell culture scaffolds. Doping in a RGD-tagged component peptide at 5 mol % improved 3T3 fibroblast attachment and viability compared to hydrogel fibres without RGD functionalisation ...
As 3D cell-based models continue to grow in popularity it is natural to try and apply existing 2D assays as a way of expanding experimental capabilities, but it is important to remember that large changes in model format can result in new experimental challenges that must first be overcome before useful data can be generated.. A common request that we often get at Visikol is if we can immunolabel microtissues encapsulated or grown in Matrigel; one of the first 3D cell culture options commercially available and a well know protein-based scaffold. Using Matrigel can result in cells expressing exciting biological phenotypes, but it can also introduce some unexpected complications with antibody labels. When immunolabeling tissues and microtissues the challenge is to get even labeling from the primary antibody. When you encapsulate tissues inside a hydrogel you have introduced an additional physical obstacle that the antibodies must first move through before they can begin to diffuse into the tissue. ...
Focal presented rat data indicating that its hydrogel can reduce internal scarring and inflammation following laminectomy, Read the full 162 word article
EN] Plasma-liquid electrochemistry was successfully used to synthesize gold nanoparticles in a watery background (AuNPs) and also embedded within a hydrogel network (PVA-AuNPs) without using any capping or reducing agents. Nanoparticles of different sizes and morphologies were obtained and the effect of the precursor concentration on the NPs size was examined. The effect of the hydrogel was also studied and it is though that it is responsible of stabilizing and avoiding the agglomeration of the NPs. This atmospheric-microplasma set-up was then used to create gold and silver mixed nanoparticles (Au-AgNPs) and PVA capped with these bimetallic nanoparticles (PVA-AuAgNPs). Their absorption properties were analysed using ultraviolet-visible (UV-Vis) spectroscopy and their size and shape using transmission electron microscopy (TEM). Antibacterial characteristics of the NPs embedded within the PVA matrix were also tested against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) showing a ...
Just stumbled upon this. Plants are grown on a thin film of hydrogel commonly used in diapers. Anyone tried that with CPs? I can see pings growing on
TY - JOUR. T1 - An injectable platelet lysate-hyaluronic acid hydrogel supports cellular activities and induces chondrogenesis of encapsulated mesenchymal stem cells. AU - Jooybar, Elaheh AU - Abdekhodaie, M.J.. AU - Alvi, Mansour. AU - Karperien, Marcel. AU - Dijkstra, Pieter Jelle. PY - 2019/1/1. Y1 - 2019/1/1. N2 - Developing scaffolds that can provide cells and biological cues simultaneously in the defect site is of interest in tissue engineering field. In this study, platelet lysate (PL) as an autologous and inexpensive source of growth factors was incorporated into a cell-laden injectable hyaluronic acid-tyramine (HA-TA) hydrogel. Subsequently, the effect of platelet lysate on cell attachment, viability and differentiation of human mesenchymal stem cell (hMSCs) toward chondrocytes was investigated. HA-TA conjugates having a degree of substitution of 20 TA moieties per 100 disaccharide units were prepared and crosslinked in the presence of horseradish peroxidase and low concentrations of ...
These are pictures showing the changing shape of the hydrogel as it walks in a water environment in responses to changes of temperature. (Credit: Kim et al. Nature Materials). In research published in Nature Materials, a team led by scientists from the RIKEN Center for Emergent Matter Science in Japan has developed a new hydrogel that works like an artificial muscle-quickly stretching and contracting in response to changing temperature. They have also managed to use the polymer to build an L-shaped object that slowly walks forward as the temperature is repeatedly raised and lowered. Hydrogels are polymers that can maintain large quantities of water within their networks. Because of this, they can swell and shrink in response to changes in the environment such as voltage, heat, and acidity. In this sense they are actually similar to the plant cells, which are able to change shape as the amount of water within them changes in response to environmental conditions.. However, most hydrogels do this ...
Hydrogel based desalination[edit]. Scheme of the desalination machine: the desalination box of volume V_box contains a gel of ... The idea of the method is in the fact that when the hydrogel is put into contact with aqueous salt solution, it swells ... "Thermodynamic model for a reversible desalination cycle using weak polyelectrolyte hydrogels". Desalination. 442: 32. doi: ... "Thermodynamic model for a reversible desalination cycle using weak polyelectrolyte hydrogels". Desalination. 442: 32. doi: ...
Temperatures above that start to dehydrate the hydrogel and cause it shrink, thus achieving shape transformation. Hydrogels ... Hydro-reactive polymers/hydrogels[edit]. Skylar Tibbits is the director of the Self-Assembly Lab at MIT, and worked with the ... This new type of 4D-printed hydrogel is more mechanically robust than other thermally actuating hydrogels and shows potential ... Thermo-reactive polymers/hydrogels[edit]. Poly(N-isopropylacrylamide), or pNIPAM, is a commonly used thermo-responsive material ...
2015). Photonic hydrogel sensors. Biotechnology advances. 34. 10.1016/j.biotechadv.2015.10.005. Ranft, Annekathrin & ... "Download citation of Photonic hydrogel sensors". ResearchGate. Retrieved 2020-05-25. "Download citation of 1D photonic defect ... "Photonic hydrogel sensors". Biotechnology Advances. Trends in In Vitro Diagnostics and Mobile Healthcare. 34 (3): 250-271. doi: ...
Chatterji, Prabha R. (5 August 1990). "Interpenetrating hydrogel networks. I. The gelatin-polyacrylamide system". Journal of ...
Van Vliet, Krystyn J. (2006); "3.032 Mechanical Behavior of Materials" Cacopardo, Ludovica (Jan 2019). "Engineering hydrogel ...
Hydrogels. *Sol-Gel nanoparticle coatings. *Self-assembled monolayers. *Layer-by-layer nanoparticle assemblies. ...
Hydrogel dressings: this type of dressing is more directed towards infected areas and those in need of a moist environment to ... hydrogel dressings, and hydrocolloid dressings. All of the listed dressing types require different materials to complete the ...
During the years 2001-2005, a PVP carrageenan hydrogel dressing for burns and wounds was developed by the PNRI as well as the ... Abad, "PVP-Carrageenan Hydrogel Dressing." 2008. De Guzman, "Radiation-Sterilized Honey Alginate Wound Dressing for Exudating ... Abad, Lucille V. "PVP-Carrageenan Hydrogel Dressing." PNRI, July 2008. Retrieved July 10, 2017. Abad, Lucille V. "Radiation ...
She created polymer hydrogel beads that are responsive to enzymes. She is working with the Medical Research Scotland to create ... Ulijn, Rein V.; McConnell, Gail; Thornton, Paul D. (2005). "Enzyme responsive polymer hydrogel beads". Chemical Communications ...
... also aids synthesis of nanocomposite hydrogels. These gels are made of water-swellable nano-scale clay ( ... Haraguchi, K. (2008). "Nanocomposite hydrogels". Current Opinion in Solid State and Materials Science. 11 (3-4): 47-54. Bibcode ... Haraguchi, K.; Takehisa T. (2002). "Nanocomposite hydrogels: a unique organic-inorganic network structure with extraordinary ...
... continuing to offer peptide-based hydrogels amongst other biomaterials. The hydrogels can be used to improve the quality of ... The synthetic peptide hydrogels were so successful that she set up the spin-out company PeptiGelDesign, a group which worked to ... Miller was awarded a small grant from the University of Manchester to develop the synthesis of peptide-based hydrogels. ... Yan, Hui; Saiani, Alberto; Gough, Julie E.; Miller, Aline F. (2006-10-01). "Thermoreversible Protein Hydrogel as Cell Scaffold ...
Stimuli-responsive gels (hydrogels, when the swelling agent is an aqueous solution) are a special kind of swellable polymer ... Richter, A.; Paschew, G.; Klatt, S.; Lienig, J.; Arndt, K.-F.; Adler, H.-J. (2008). "Review on Hydrogel-based pH Sensors and ... To avoid the electrolysis of water hydrogel-based microfluidic devices are mainly based on temperature-responsive polymers with ... Microvalves based on stimuli-responsive hydrogels show some advantageous properties such as particle tolerance, no leakage and ...
Dumville JC, Stubbs N, Keogh SJ, Walker RM, Liu Z (February 2015). Dumville JC (ed.). "Hydrogel dressings for treating pressure ... Cochrane reviews summarise evidence on alginate dressings, foam dressings, and hydrogel dressings. Due to a lack of robust ...
The first step in this direction was hydrogel-tissue chemistry (HTC) in which "specific classes of native biomolecules in ... He is known for creating and developing the technologies of hydrogel-tissue chemistry (e.g. CLARITY, STARmap) and optogenetics ... Viviana Gradinaru; Jennifer Treweek; Kristin Overton; Karl Deisseroth (2018). "Hydrogel-tissue chemistry: principles and ... A key feature of HTC is that the hydrogel-tissue hybrid "becomes the substrate for future chemical and optical interrogation ...
At its simplest, a bioreactor space will be created between tissue layers through the use of hydrogel injections to create a ... Zhu, Junmin (June 2010). "Bioactive modification of poly(ethylene glycol) hydrogels for tissue engineering". Biomaterials. 31 ( ... "Cell-Type Specific Four-Component Hydrogel". PLOS ONE. 9 (1): e86740. Bibcode:2014PLoSO...986740A. doi:10.1371/journal.pone. ... Tuning the Mechanical Properties of Chondroitin Sulfate Hydrogels by Copolymerization with Oligo (ethylene glycol) Diacrylates ...
Due to this it is used widely in wound care products, including glycerin based hydrogel sheets for burns and other wound care. ... "Functional Food Design Rules". Stout, Edward I.; McKessor, Angie (February 2012). "Glycerin-Based Hydrogel for Infection ...
Lu, Hoang D.; Charati, Manoj B.; Kim, Iris L.; Burdick, Jason A. (March 2012). "Injectable shear-thinning hydrogels engineered ... "Self-assembled supramolecular hydrogels formed by biodegradable PEO-PHB-PEO triblock copolymers and alpha-cyclodextrin for ... "Supramolecular Nanotube Hydrogels: Remarkable Resistance Effect of Confined Proteins to Denaturants". Chemistry of Materials. ... "Supramolecular polymeric hydrogels". Chemical Society Reviews. 41 (18): 6195-214. doi:10.1039/c2cs35264h. PMID 22890548.CS1 ...
By 1974 they had developed a suitable hydrogel and in 1976 his lab had the first enzymatic release of a ligand from a polymer ... The next step was the inclusion of a degradable hydrogel, and clinical trials. By 2009, there was full self-assembly of the ... Kopeček is regarded as one of the pioneers in development of biomedicinal polymers such as hydrogel implants and design of new ... Buwalda, S. J., Boere, K. W., Dijkstra, P. J., Feijen, J., Vermonden, T., & Hennink, W. E. Hydrogels in a historical ...
Hydrogels are beneficial because they have a high water content, which allows the ease of nutrients and small materials to pass ... Hydrogel scaffolds are created by cross-linking hydrophilic polymers through various reaction such as free radical ... Zhu J, Marchant RE (September 2011). "Design properties of hydrogel tissue-engineering scaffolds". Expert Review of Medical ...
Bio-inspired self-healing structural color hydrogels that maintain the stability of an inverse opal structure and its resultant ... "Bio-inspired self-healing structural color hydrogel". Proceedings of the National Academy of Sciences. 114 (23): 5900-5905. ...
Hydrogel dressings may have shown a slight advantage over standard dressings, but the quality of the research is of concern. ... There are many types of dressings used to treat diabetic foot ulcers such as absorptive fillers, hydrogel dressings, and ... Dumville JC, O'Meara S, Deshpande S, Speak K (July 2013). "Hydrogel dressings for healing diabetic foot ulcers". The Cochrane ... Biologically active bandages that combine hydrogel and hydrocolloid traits are available, however more research needs to be ...
Cellulose nanofiber hydrogel is created by biosynthesis. The hydrogels can then be treated with a polymer solution or by ... To reduce delamination, the hydrogel can be treated with silicic acid, which creates strong covalent cross-links between layers ... hydrogels and papers. E.g. nanocellulose mixed with conducting polymers such as PEDOT:PSS show synergetic effects resulting in ... aerogels and hydrogels to realize the future of bio-based electronics. artikel-id PF4.1: PaperCon 2019, Indianapolis, USA: ...
Mechanics of gelation Oliveira, J.T.; Reis, R.L. (2008). "Hydrogels from polysaccharide-based materials: Fundamentals and ... Ahmed, Enas M. (2015). "Hydrogel: Preparation, characterization, and applications: A review". Journal of Advanced Research. 6 ( ...
"Multifunctional photo-crosslinked polymeric ionic hydrogel films". Polymer Chemistry. 5 (8): 2824. doi:10.1039/C3PY01708G. ...
The ability of hydrogels to be tailored to specific needs allows them to be used as an adaptable scaffold material, that are ... Hydrogel alginates have emerged as one of the most commonly used materials in organ printing research, as they are highly ... Alginate hydrogel that is suitable for extrusion printing is also often less structurally and mechanically sound; however, this ... Augst, Alexander D.; Kong, Hyun Joon; Mooney, David J. (2006-08-07). "Alginate Hydrogels as Biomaterials". Macromolecular ...
Spherical hydrogels, in micro-size (50-600 µm diameter) with 3-dimensional cross-linked polymer, can be used as drug carrier to ... These hydrogels called microgels. They may possess a negative charge as example DC-beads. By ion-exchange mechanism, a large ... an example being hydrogels). Sustained release's definition is more akin to a "controlled release" rather than "sustained". ...
It can form hydrogels. 2-Acrylamido-2-methylpropane sulfonic acid (AMPS) v t e. ...
Hydrogels Microparticles Nanoparticles Kong; Li; Wang; Adhikari (2011). "Preparation of gelatin microparticles using water-in- ... "Mesenchymal stem cell and gelatin microparticle encapsulation in thermally and chemically gelling injectable hydrogels for ...
Cross-linked Hydrogel The reaction scheme below is a terpolymerization to form a cross-linked hydrogel. The reactant ammonium ... It forms a three-dimensional hydrogel when cross-linked with N,N'-methylene-bis-acrylamide (MBAm) or N,N'-cystamine-bis- ... PNIPA is one of the most studied thermosensitive hydrogels. In dilute solution, it undergoes a coil-to-globule transition. ... Upon heating above the LCST, the hydrogel goes from hydrophilic to hydrophobic state. This conversion results in an expulsion ...
It can form hydrogels. PolyMAPTAC, or poly[(3-(methacryloylamino)-propyl] trimethylammonium chloride), is similar. v t e. ...
An immunotherapy drug embedded in a slow-release hydrogel invented at Rice in collaboration with the University of Texas Health ... The hydrogel in the new study is also welcoming to cells, but when the invaders are cancer cells, theyre in for trouble. ... "The MDP hydrogel provides a unique environment for the release of CDN that other gels just cant match," Hartgerink said. ... A synthetic, injectable hydrogel developed at Rice University boosted the toxicity of a new class of cancer-fighting ...
... is a highly elastic and adhesive surgical hydrogel that can seal wounds without the need for sutures. MeTro set... ... Hydrogel Paper Instantly Generates 110 Volts of Electricity - Duration: 2:08. IEEE Spectrum 131,200 views ... MeTro (methacryloyl-substituted tropoelastin) is a highly elastic and adhesive surgical hydrogel that can seal wounds without ...
Our hydrogel works entirely differently because it is localized, just in the eye, and deactivates MMPs by eliminating the zinc ... The hydrogel works locally by deactivating the harmful MMP enzymes only in the cornea. Credit: UNH/UCD.. ... The end goal is to make the hydrogel into a contact lens that would allow more localized treatment of the eye and avoid side ... The research was done in vitro and ex vivo (on extracted cornea tissue) and suggests that the new hydrogel could be a viable ...
SpaceOAR hydrogel acts as a protective spacer between the prostate and the rectum and has been clinically proven to reduce the ... SpaceOAR hydrogel is placed by Dr. Steven Eric Finkelstein M.D., FACRO, radiation oncologist and Dr. Michael Jenkins, M.D., a ... The study found that the patients that did not receive SpaceOAR hydrogel experienced a clinically significant decline in bowel ... In a prospective, randomized, multi-center clinical trial in the United States, patients treated with SpaceOAR hydrogel prior ...
Hydrogels generated in this manner are sometimes called permanent hydrogels. One notable method of initiating a ... When used as scaffolds, hydrogels may contain human cells to repair tissue. They mimic 3D microenvironment of cells. Hydrogel- ... The most commonly seen environmental sensitivity in hydrogels is a response to temperature. Many polymers/hydrogels exhibit a ... Future work is focused on better anti-toxicity of hydrogels, varying assembly techniques for hydrogels making them more ...
There are high hopes for hydrogel. To its many existing applications, we can now add a heat-sensitive, conductive, drug- ... The new hydrogel. In December 2015, the MIT team announced the creation of a set of "tough hydrogels" containing 70-95% water, ... Hydrogels also prevent the dressing from sticking to the wound surface. Hydrogels are strong and flexible, and they can be ... What is a hydrogel?. Hydrogels feature in various everyday products, from soft contact lenses and condoms to disposable diapers ...
Hydrogels are a fascinating class of polymers which show an immense ability of swelling under the influence of temperature, pH ... Biosensor biosensors chemical sensors hydrogels microsystem technology polymer polymer hydrogels polymers Editors and ... Polymer Hydrogels to Enable New Medical Therapies P. Welzel, M. Nitschke, U. Freudenberg, A. Zieris, T. Götze, M. Valtink et al ... Hydrogels are a fascinating class of polymers which show an immense ability of swelling under the influence of temperature, pH ...
Bioactive hydrogel promises faster wound healing A new study published in the journal Science Advances presents the use of a ... Mechanical training makes synthetic hydrogels perform more like muscle Human skeletal muscles have a unique combination of ... Researchers develop NO-scavenging hydrogel for treatment of rheumatoid arthritis Nitric oxide (NO) prevents high blood pressure ... which can be incorporated into hydrogels to amplify their effects. ...
Hydrogels have the capability to absorb large amounts of water or biological fluids into their three-dimensional hydrophilic ... Hydrogels can be obtained from synthetic and/or natural resources. Synthetic hydrogels exhibit high water absorption capacities ... Natural hydrogels are often derived from polysaccharides and proteins. Protein-based hydrogels have substantial advantages such ... Rutz AL, Shah RN (2016) Protein-based hydrogels. In: Kalia S (ed) Polymeric hydrogels as smart biomaterials. Springer, ...
Hydrogel dressings are a hydrogel pad in contact with the wound. The hydrogel is a hydrated three-dimensional (3D) network ... The hydrogel dressings can be prepared in the shape of the film which can directly place at the wound site. Besides, there is a ... Hydrogel dressing possesses a highly hydrated 3D polymeric network and can bind several-fold more water as compared to their ... Importantly, all hydrogels need to satisfy the basic requirements of biocompatibility in clinical use as well as possess unique ...
The hydrogel isnt quite ready for consumers to start seeing yet, but the team is working on a new ingredient that would ... The "hydrogel" coating is an absorbent material that is derived from shrimp and crab shells. This material is able to help ... The hydrogel developed by Li suppresses this breathing from happening, but also kills the bacteria that cause rotting. ...
Home , Augmenix wins FDA approval for tissue marking hydrogel. Augmenix wins FDA approval for tissue marking hydrogel. Ira ... The hydrogel remains stable and visible in tissue for three months, long enough for radiotherapy, and then is absorbed and ... Augmenix, a privately held company founded in 2008, is focused on utilizing hydrogel technology in the fields of tissue marking ... Injectable through a fine needle, small hydrogel injections are clearly visible in the lung, breast, prostate and other tissues ...
Described is a super elastic epoxy hydrogel that is easy to manufacture and can be engineered for various performance ... Also described are methods of enhancing the performance of this hydrogel and other hydrogels. Various polymer hydrogel ... Hydrogels are a class of polymer chain products that are water-insoluble. Hydrogels are highly absorbent polymer materials and ... A topical skin care product formed of an epoxy hydrogel of claim 1. 43. A method of producing epoxy hydrogel as a powder ...
An improved hydrogel adhesive, particularly adapted for adhesion and contact to tissue. It is especially useful in attaching ... It may also be used to provide mechanical attachment of the hydrogel to the base if the hydrogel is being used in a dried ... When the polymer of the hydrogel is crosslinked to an adequate degree, bulk hydrogel is strong enough, even when swelled with ... The adhesive qualities of the hydrogels are affected by the degree of water content of the hydrogel. Aggressive adhesion ...
... , Acryderm, Aquaflo, Aquagauze, Carradres, Carraguaze, Carrasyn, Dermagauze, Felxigel, SAF-Gel, Solosite, ... Hydrogel Dressing. Aka: Hydrogel Dressing, Acryderm, Aquaflo, Aquagauze, Carradres, Carraguaze, Carrasyn, Dermagauze, Felxigel ... Infected wound (amorphous hydrogels such as Intrasite). *Monitor wound daily if infected ...
Although the hydrogel is only about the size of a sugar grain, when consumed with water, the grain expands into gel-form in the ... "Hydrogel smart pill shows promise as weight loss aid." Medical News Today. MediLexicon, Intl., 24 Jun. 2014. Web.. 17 Dec. ... McNamee, D. (2014, June 24). "Hydrogel smart pill shows promise as weight loss aid." Medical News Today. Retrieved from. ... Again, the trial found only minor side effects to be associated with the hydrogel - bloating, flatulence, abdominal pain and ...
The metal may also be in the form of a foil or wire located within the hydrogel such as polyurethane, thereby making the ... Other polymers besides hydrogel may be used with the radiopaque material being disbursed therein. ... A spinal implant for replacing the natural nucleus of the disc made from a polymer such as hydrogel having a radiopaque ... Thus, it may vary from 1.19 for a hydrogel of 38% EWC to 1.73 for a hydrogel of 80% EWC. For an 80% EWC hydrogel, the volume of ...
Evolution of xylem lignification and hydrogel transport regulation. C. Kevin Boyce, Maciej A. Zwieniecki, George D. Cody, Chris ... Evolution of xylem lignification and hydrogel transport regulation. C. Kevin Boyce, Maciej A. Zwieniecki, George D. Cody, Chris ... Evolution of xylem lignification and hydrogel transport regulation. C. Kevin Boyce, Maciej A. Zwieniecki, George D. Cody, Chris ... Evolution of xylem lignification and hydrogel transport regulation Message Subject (Your Name) has sent you a message from PNAS ...
... which are subsequently crosslinked to form hydrogel networks. The invention also relates to the use of these hydrogel networks ... That copolymer is subsequently crosslinked to form a hydrogel network. More particularly, the present invention relates to the ... The hydrogel as in claims 9 or 34, wherein the hydrogel has a water content of at least about 85%. ... One polymer system that is compatible with living systems and does readily absorb water is the hydrogels. Hydrogels are three- ...
Jart+s Brightening Infusion Hydrogel Mask at Sephora. It maximizes the penetration of active ingredients for brighter-looking ... The Brightening Infusion Hydrogel Mask contains galactomyces, vitamin C, and licorice extract to moisturize and brighten the ... Jart+Brightening Infusion Hydrogel Mask. SIZE 1 x 1.2 oz mask/ 1 x 34 g•ITEM 1622430 ...
The resultant hydrogel, containing charged inorganic structures that align cofacially in a magnetic flux12,13,14,15,16,17,18,19 ... Taking this cartilage as the model, Mingjie Liu and colleagues have developed a hydrogel with mechanical properties dominated ... Crucial to the behaviour of this hydrogel is the serendipitous discovery of cofacial nanosheet alignment in aqueous colloidal ... but here a hydrogel is described whose properties are dominated by electrostatic repulsion between negatively charged titanate ...
... cations which are capable of cross-linking said precursor material to form a fibre reinforced hydrogel as the hydrogel product. ... A method of producing a hydrogel product comprises impregnating a coherent fibrous structure with an aqueous solution of a ... The hydrogels are in a hydrated form and are capable of donating moisture to a wound. The hydrogels may be used for treating ... A hydrogel is a cross-linked macromolecular network swollen with water or biological fluids. It is known that hydrogels are ...
Silicone hydrogel contact lens. US6891010 *. Oct 29, 2001. May 10, 2005. Bausch & Lomb Incorporated. Silicone hydrogels based ... A hydrogel is a hydrated cross-linked polymeric system that contains water in an equilibrium state. Silicone hydrogels (i.e., ... Silicone hydrogel contact lenses and methods of making silicone hydrogel contact lenses. ... Silicone Hydrogel Contact Lenses and Methods of Making Silicone Hydrogel Contact Lenses. ...
SilvaSorb Hydrogel was designed for targeted antimicrobial protection. SilvaSorb Gel helps hydrate dry wounds and maintain an ... SilvaSorb Hydrogel 8 oz. The SilvaSorb Gel helps hydrate dry wounds to promote faster, healthier healing. ...
... plural hydrogels) 1. A colloid gel in which water is the continuous phase; they have a number of medical and industrial ... hydrogel. Noun (plural hydrogels). *A colloid gel in which water is the continuous phase; they have a number of medical and ... How would you define hydrogel? Add your definition here.. Please enable JavaScript to view the comments powered by Disqus.. ...
Robinson Vetalinex Hydrogel is available online with fast delivery from VioVet, the trusted supplier of veterinary medication, ... Robinson Vetalintex Hydrogel is a clear, viscose starch based hydrogel dressing, specially developed for wound maintenance. By ... Reviews of Robinson Vetalintex Hydrogel. Read our customers reviews of Robinson Vetalintex Hydrogel ... Questions & Answers for Robinson Vetalintex Hydrogel. Below are some recent questions weve received regarding Robinson ...
... silicone hydrogel (SiHy) contact lenses have become the predominant lens choice of eye care professionals. ... 7 Guillon M. Are silicone hydrogel contact lenses more comfortable than hydrogel contact lenses? Eye Contact Lens. 2013;39(1): ... SiHy lenses have a higher Dk/t than hydrogel lenses, so SiHy wearers generally do not experience the effects of limited corneal ... Many eye care professionals have assumed that hydrogel lenses must be less comfortable than SiHy lenses due to their higher ...
The outer covering comprises a hydrogel polymerized about the textile insert in situ. ... A hydrogel tube as made in Example V of a suitable diameter, preferably reinforced by a textile knitwork having a perfectly ... A hydrogel tube of a suitable inner diameter was prepared in the well-known process of rotary or centrifugal casting, as ... Method for manufacturing hydrogel tubes. US4298002 *. 10 Sep 1979. 3 Nov 1981. National Patent Development Corporation. Porous ...
Mayo Clinic and MIT provides proof-of-concept and first preclinical evidence in animal models that a shear-controlled hydrogel- ... Controlling bleeding disorders with fitted hydrogel casts A hydrogel easily injected into blood vessels could help stop ... The STB is a mixture of two components that form a malleable hydrogel: gelatin molecules combined with small discs of silicate ... "This new approach to vascular embolization is based on a hydrogel composite with phase properties we can reliably control with ...
San Diego bioengineers have shown that a new injectable hydrogel can repair damage from heart attacks,... ... The hydrogel is made from cardiac connective tissue that is stripped of heart muscle cells through a cleansing process, freeze- ... "Our data show that this hydrogel can increase cardiac muscle and reduce scar tissue in the region damaged by the heart attack, ... In a new study in pigs, University of California, San Diego bioengineers have shown that a new injectable hydrogel can repair ...
  • The crosslinks which bond the polymers of a hydrogel fall under two general categories: physical and chemical. (wikipedia.org)
  • Disposable diapers where they absorb urine, or in sanitary napkins Contact lenses (silicone hydrogels, polyacrylamides, polymacon) EEG and ECG medical electrodes using hydrogels composed of cross-linked polymers (polyethylene oxide, polyAMPS and polyvinylpyrrolidone) Water gel explosives Rectal drug delivery and diagnosis Encapsulation of quantum dots Breast implants Glue Granules for holding soil moisture in arid areas Dressings for healing of burn or other hard-to-heal wounds. (wikipedia.org)
  • Chemomechanical polymers are mostly also hydrogels, which upon stimulation change their volume and can serve as actuators or sensors. (wikipedia.org)
  • To create hydrogels, the polymer chains that form their basis are either chemically synthesized or derived from natural polymers. (medicalnewstoday.com)
  • Hydrogels are a fascinating class of polymers which show an immense ability of swelling under the influence of temperature, pH value or concentrations of different species in aqueous solutions. (springer.com)
  • To improve their mechanical properties, hybrid hydrogels are synthesized by combining natural polymers with synthetic ones. (springer.com)
  • The main approach to obtain hybrid hydrogels is grafting natural polymers with synthetic one and vice versa. (springer.com)
  • The hydrogel is a hydrated three-dimensional (3D) network consisting of physically or chemically cross-linked bonds of hydrophilic polymers. (wikipedia.org)
  • Polymers used in hydrogels include chitosan, dextran, kappa-carrageenan, alginate/gelatin and collagen/glycosaminoglycan. (wikipedia.org)
  • It has been discovered that partially dehydrated hydrogels, in which the hydrogel polymers contain controlled cross-linking, exhibit excellent adhesive properties, particularly in attaching to moist body tissue. (google.com.au)
  • Other polymers besides hydrogel may be used with the radiopaque material being disbursed therein. (google.com)
  • A method as claimed in any one of claims 1 to 3 wherein the hydrogel precursor is sodium alginate, sodium carboxymethyl cellulose, sodium pectinate, sodium O-carboxymethyl chitosan (OCC), sodium N,O-carboxymethyl chitosan (NOCC), sodium polyacrylate, and naturally occurring gums and synthetic polymers containing pendant carboxylic acid groups (hummectants). (google.co.uk)
  • Various methods of employing plastics, such as, for example hydrogels from co-polymers of glycol methacrylate and glycol-bis-methacrylate for prosthetic purposes are known. (google.ca)
  • Hydrogels can be defined as water-swollen networks of polymers. (sigmaaldrich.com)
  • The first generation of hydrogels used for 3D cell culture was generated by doing an extraction of ECM polymers from Engelbreth-Holm-Swarm (EHS) murine sarcoma cell basal membranes. (sigmaaldrich.com)
  • Each chapter in this book describes a selected class of polymeric hydrogels, such as superabsorbent hybrid nanohydrogels, conducting polymer hydrogels, polysaccharide-based or protein-based hydrogels, or gels based on synthetic polymers. (worldcat.org)
  • Hydrogels are formed from networks of super-absorbent, chain-like polymers. (theengineer.co.uk)
  • Manufacturers were able to improve the hydrogel polymers used in contact lenses over the two decades after the FDA first approved hydrogel contact lenses in the US. (lens.com)
  • The improvement of hydrogel polymers led to silicone hydrogel contact lenses. (lens.com)
  • The treatment involved a simple wound dressing that included a specially designed hydrogel -- a water-based, three-dimensional framework of polymers. (redorbit.com)
  • For this purpose, they decided to explore conducting hydrogels -- water-swollen, biocompatible polymers that can transmit bioelectrical signals. (acs.org)
  • Wang R, Leber N, Buhl C, Verdonschot N, Dijkstra PJ, Karperien M: Cartilage adhesive and mechanical properties of enzymatically crosslinked polysaccharide tyramine conjugate hydrogels, Polymers for Advanced Technologies 2014, 25:568-574. (utwente.nl)
  • Hydrogels are hydrophilic in nature with macromolecular groups, produced by chemical or physical crosslinking of soluble polymers. (scirp.org)
  • A hydrogel sheet patterned with various types of polymers (indicated by colors in cartoon) takes different shapes in response to high pH and to high salt concentration. (acs.org)
  • The team first created hydrogels using different chemical formulations of polymers to see which supported the growth of human intestinal organoids in the lab. (nih.gov)
  • Hydrogel dressings are not new, with the first ones dating back to the 1950s. (medicalnewstoday.com)
  • Familiar hydrogel dressings include free-flowing gels available in tubes and foil packets, preparations where hydrogel is saturated onto a gauze pad or strips, or a sheet of gel supported by a thin fiber mesh. (medicalnewstoday.com)
  • Hydrogel dressings provide moisture, promote healing and remove dead tissue from wounds. (medicalnewstoday.com)
  • Hydrogel dressings are a hydrogel pad in contact with the wound. (wikipedia.org)
  • The physical, mechanical, and biological properties of hydrogels used as dressings can modulate by some modifications including chemical modification of polymer, crosslinking strategies, copolymerization, and nanoparticle incorporation. (wikipedia.org)
  • The hydrogel dressings can be prepared in the shape of the film which can directly place at the wound site. (wikipedia.org)
  • Besides, there is a new generation of hydrogel dressings that can be sprayed or injected in situ. (wikipedia.org)
  • The invention relates more particularly, but not exclusively, to such hydrogels that are useful as wound dressings. (google.co.uk)
  • There are however disadvantages with prior art hydrogel dressings (c.g. (google.co.uk)
  • Hydrogel dressings like INTRASITE GEL are interactive dressings that provide additional moisture to wounds rehydrating necrotic and sloughy tissue to effect debridement, and absorb wound fluid. (smith-nephew.com)
  • This review article prescribes about the application of hydrogels with diversified prospects in tissue engineering, wound care dressings, soft tissue recovery and plastic surgery. (scirp.org)
  • Hydrogel dressings are one type of available dressing. (cochrane.org)
  • Hydrogel dressings contain a large amount of water that keeps ulcers moist rather than letting them become dry. (cochrane.org)
  • In this study we investigated whether there is any evidence that pressure ulcers treated with hydrogel dressings heal more quickly than those treated with other types of dressings or skin surface (topical) treatments. (cochrane.org)
  • In June 2014 we searched for as many relevant medical studies as we could find that had a robust design (randomised controlled trials) that had compared hydrogel dressings with other treatments for pressure ulcers. (cochrane.org)
  • From the results of these studies we could not tell whether hydrogel wound dressings heal pressure ulcers more quickly or slowly than other types of dressing or topical treatments. (cochrane.org)
  • More research of better quality is needed before it can be determined whether hydrogel dressings are better or worse at healing pressure ulcers than other types of dressings or topical treatments. (cochrane.org)
  • It is not clear if hydrogel dressings are more or less effective than other treatments in healing pressure ulcers or if different hydrogels have different effects, Most trials in this field are very small and poorly reported so that risk of bias is unclear. (cochrane.org)
  • Dressings are widely used to treat pressure ulcers and there are many different dressing options including hydrogel dressings. (cochrane.org)
  • To assess the effects of hydrogel dressings on the healing of pressure ulcers in any care setting. (cochrane.org)
  • The MDP hydrogel provides a unique environment for the release of CDN that other gels just can't match," Hartgerink said. (rice.edu)
  • Ulta Beauty's 24K Magic Hydrogel Eye Masks are 24 karat gold-infused under eye gels that provide an instant cooling sensation that will make your eyes look and feel more awake. (ulta.com)
  • Hartgerink is a pioneer in the development of self-assembling multidomain peptide (MDP) hydrogels, which mimic the body's extracellular matrix to encourage the growth of cells and vascular systems for tissue repair. (rice.edu)
  • The research was done in vitro and ex vivo (on extracted cornea tissue) and suggests that the new hydrogel could be a viable therapeutic option for treating corneal melting. (unh.edu)
  • When used as scaffolds, hydrogels may contain human cells to repair tissue. (wikipedia.org)
  • Injectable hydrogels which can be used as drug carriers for treatment of diseases or as cell carriers for regenerative purposes or tissue engineering. (wikipedia.org)
  • Providing absorption, desloughing and debriding of necrotic and fibrotic tissue Hydrogels that are responsive to specific molecules, such as glucose or antigens, can be used as biosensors, as well as in DDS. (wikipedia.org)
  • Hydrogels also possess a degree of flexibility very similar to natural tissue, due to their significant water content. (wikipedia.org)
  • Already meeting a wide range of functions, hydrogels are dreaming of a bright future, including a role in spinal cord regrowth, nerve and tissue engineering, and even organ generation. (medicalnewstoday.com)
  • A new study published in the journal 'Science Advances' presents the use of a novel tissue engineering material composed of bioactive injectable hydrogel to speed up the rate of healing in wounded tissues. (news-medical.net)
  • Therefore, this kind of hydrogels is known as smart biomaterials for controlled release, tissue engineering, regenerative medicine, and other applications. (springer.com)
  • The potential applications of these polypeptide-based hydrogels in the fields of superabsorbent development, tissue engineering, and controlled release are reported. (springer.com)
  • Concerning extracellular matrix similarity, hydrogels used for wound healing applications can provide a cell-friendly 3D environment to promote tissue regeneration, with or without the presence of cells embedded in the scaffold. (wikipedia.org)
  • Augmenix, a privately held company founded in 2008, is focused on utilizing hydrogel technology in the fields of tissue marking and radiation oncology. (bostonherald.com)
  • The hydrogel remains stable and visible in tissue for three months, long enough for radiotherapy, and then is absorbed and cleared from the body, the company said. (bostonherald.com)
  • An improved hydrogel adhesive, particularly adapted for adhesion and contact to tissue. (google.com.au)
  • Aggressive adhesion develops during the initial phase of tissue contact when the hydrogel is hydrating or rehydrating. (google.com.au)
  • Although many adhesive applications, particularly those involving tissue, are included within the purview of the hydrogel compositions of this invention, a preferred use is found as an adhesive for attaching pacing leads to heart tissue, particularly epicardial tissue and other moist internal tissue. (google.com.au)
  • The doctor makes a small incision in the skin to insert the canulla, adding the hydrogel above the muscle tissue. (ehow.co.uk)
  • In a new study in pigs, University of California, San Diego bioengineers have shown that a new injectable hydrogel can repair damage from heart attacks, help the heart grow new tissue and blood vessels, and get the heart moving closer to how a healthy heart should. (sify.com)
  • Our data show that this hydrogel can increase cardiac muscle and reduce scar tissue in the region damaged by the heart attack, which prevents heart failure. (sify.com)
  • The hydrogel is made from cardiac connective tissue that is stripped of heart muscle cells through a cleansing process, freeze-dried and milled into powder form, and then liquefied into a fluid that can be easily injected into the heart. (sify.com)
  • The hydrogels are designed to dissolve in the body as they are replaced by natural, functional tissue. (eurekalert.org)
  • Hydrogels can also carry chemical or biological prompts that determine the scaffold's structure or affinity to the surrounding tissue. (eurekalert.org)
  • Naturally based" hydrogels such as Matrigel (made of native extracellular matrix proteins) and collagen (the major extracellular matrix protein) have been explored extensively for applications in three-dimensional tissue culture and regenerative medicine. (sciencemag.org)
  • Hydrogels offer tissue-like compliance, stretchability, fracture toughness, ionic conductivity and compatibility with biological tissues. (nature.com)
  • The Hydrogel Perirectal Spacer procedure can reduce tissue exposure to radiotherapy for patients undergoing treatment for prostate cancer. (nuffieldhealth.com)
  • In document (4) the hydrogels, which were used for soft tissue filling, had a solid content of between 1.5 and 2.5 percent by weight, which was within the claimed range. (epo.org)
  • The hydrogel containing silica nanoparticles can be infused with cells to promote tissue growth and work as a bandage to control bleeding. (medindia.net)
  • With the ever increasing demand for suitable tissue engineering and drug delivery systems, hydrogel fiber spinning has drawn increasing attention due to its ability to create three-dimensional (3D) structures using biomaterials. (intechopen.com)
  • Hydrogel materials have shown a great promise to be used as templates for tissue engineering and implantable devices. (intechopen.com)
  • Among the many production techniques available, advanced fiber processing, such as coaxial and triaxial spinning of natural hydrogels, has attracted a great deal of attention because the basic core-sheath structure provides a drug delivery system capable of delivering high concentrations of drug for localized drug delivery and tissue engineering applications. (intechopen.com)
  • Aside from the specific materials used in certain applications such as orthopedics, dental implants and artificial vascular materials, the focus of this chapter is on the role of naturally occurring hydrogels to develop biofibres with the final use as biocompatible templates for the purpose of drug delivery systems or the building blocks of tissue scaffolds. (intechopen.com)
  • Gerecht says the hydrogel is constructed in such a way that it allows tissue regeneration and blood vessel formation to occur very quickly. (redorbit.com)
  • Inflammatory cells are able to easily penetrate and degrade the hydrogel, enabling blood vessels to fill in and support wound healing and the growth of new tissue," she said. (redorbit.com)
  • Besides key advances in tissue engineering (especially for conductive tissue, such as for the brain and the heart), there has been innovation also in the area of drug delivery on-demand, with engineered hydrogels capable of repeated response to light, thermal, or electric stimuli. (ingentaconnect.com)
  • An injectable CNS-ECM derived hydrogel capable of in vivo polymerization and conformation to irregular lesion geometries may aid in tissue reconstruction efforts following complex neurologic trauma. (nih.gov)
  • The injectable hydrogel facilitates the repair of the defect with new cartilage tissue. (utwente.nl)
  • Exploration on hydrogel fibres concerning about smart based application in the medical sector has stimulated great interests for the last couple of years due to its wide range of purposes that include actuators, artificial adhesives, transplantable tissue organs, cell scaffolds, cell therapeutics, wound healing, cartilage or bone regeneration. (scirp.org)
  • This is due to the fact that, hydrogel fibers are biocompatible and their similarity about physical properties is in relation with natural tissue. (scirp.org)
  • According to the researchers, the NO-responsive hydrogel could be used not only as the basis for a drug-delivery system for inflammation modulators, but as a potential tissue scaffold as well. (postech.ac.kr)
  • Apply enough Tegaderm Hydrogel Wound Filler to cover the wound base and any necrotic tissue, to a depth of approximately 5 mm thick, with no overlap onto the surrounding skin. (cvs.com)
  • An agarose-carbomer (AC1) hydrogel, already used in SCI repair strategies, was here investigated as a delivery system capable of an effective chABC administration: the material ability to include chABC within its pores and the possibility to be injected into the target tissue were firstly proved. (mdpi.com)
  • Hydrogels, because of their tissue-like properties, have been used as supporting matrices to deliver cells into infarcted cardiac muscle. (mdpi.com)
  • Bioactive and biocompatible hydrogels mimicking biochemical and biomechanical microenvironments in native tissue are needed for successful cardiac tissue regeneration. (mdpi.com)
  • Many hydrogels, including natural polymer hydrogels, synthetic polymer hydrogels, and natural/synthetic hybrid hydrogels are employed for cardiac tissue engineering. (mdpi.com)
  • In this review, types of hydrogels used for cardiac tissue engineering are briefly introduced. (mdpi.com)
  • Li Z, Guan J. Hydrogels for Cardiac Tissue Engineering. (mdpi.com)
  • Rejuvenate dull complexions with the Erno Laszlo Detoxifying Hydrogel Mask . (skinstore.com)
  • Natural hydrogels are often derived from polysaccharides and proteins. (springer.com)
  • Inevitably, natural hydrogels right is now gradually replaced by synthetic types due to their larger amount of water absorption capacity, durability alongside with wide ranges of raw chemical resources. (scirp.org)
  • Hydrogels developed at Rice are designed to be injectable and create a mimic of cellular scaffolds in a desired location. (eurekalert.org)
  • The researchers, Joel Schneider and Darrin Pochan, have developed a peptide-based hydrogel that, once implanted in the human body, become scaffolds for cells to hold onto and grow. (theengineer.co.uk)
  • Conducting Polymer Hydrogels. (worldcat.org)
  • Shaped organic polymer hydrogels, especially contact lenses, are provided with opaque or translucent coloring so as to be capable of masking effectively any underlying color, e.g. the natural color of the eye. (google.ca)
  • 5. Immobilization of Biomolecules and Cells on and Within Synthetic Polymer Hydrogels. (routledge.com)
  • The team that designed and created the new hydrogel dressing was led by Prof. Xuanhe Zhao, of the Massachusetts Institute of Technology (MIT) Department of Mechanical Engineering. (medicalnewstoday.com)
  • Alginate hydrogels combined with aloe vera provide a wound dressing that keeps the wound moist and allows for regeneration of cells. (medicalnewstoday.com)
  • Hydrogels also prevent the dressing from sticking to the wound surface. (medicalnewstoday.com)
  • Hydrogel dressing possesses a highly hydrated 3D polymeric network and can bind several-fold more water as compared to their dry weight and can thereby maintain a high level of moisture at the wound bed. (wikipedia.org)
  • Robinson Vetalintex Hydrogel is a clear, viscose starch based hydrogel dressing, specially developed for wound maintenance. (viovet.co.uk)
  • The mechanically durable and biologically favorable aneroin hydrogel shows clear advantages and could be used in various biomedical applications, especially for cell-containing biomaterials, cell-carrier patches, bio-artificial grafts, and burn dressing materials. (medindia.net)
  • A burn wound dressing using the new hydrogel could have enormous potential for use in applications beyond common burns, including treatment of diabetic patients with foot ulcers, Harmon said. (redorbit.com)
  • Gerecht and Harmon say they don't fully understand how the hydrogel dressing is working. (redorbit.com)
  • At that point, it has been studied about calcium-alginate microcapsules for cell engineering application [5] and then, some researchers have constructed synthetic hydrogels ( Figure 1 ) composed of natural polymer such as collagen to attain novel dressing substances, showing optimal conditions for healing of burns and wound dressing [6]. (scirp.org)
  • Alternatively, a sterile gauze pad may be saturated with Tegaderm Hydrogel Wound Filler and placed into the wound with no overlap onto the surrounding skin.Apply an appropriate cover dressing to help manage the wound drainage and maintain a moist wound environment. (cvs.com)
  • This hydrogel dressing is sterile, 4in x 4in. (medical-supplies-equipment-company.com)
  • A hydrogel is a network of crosslinked polymer chains that are hydrophilic, sometimes found as a colloidal gel in which water is the dispersion medium. (wikipedia.org)
  • In a prospective, randomized, multi-center clinical trial in the United States, patients treated with SpaceOAR hydrogel prior to prostate cancer radiation treatment demonstrated bowel, urinary, and sexual benefits through three years of follow-up. (prweb.com)
  • The outer covering comprises a hydrogel polymerized about the textile insert in situ. (google.ca)
  • Top: schematic representation of the treatment of a focal cartilage defect with an injectable in situ gelating hydrogel. (utwente.nl)
  • The hydrogel may be rendered opaque by precipitation in situ of a white or yellow water-insoluble, inorganic or organic material e.g. barium sulphate or an optical brightener and then colored with a suitable dyestuff. (google.ca)
  • Gavin Braithwaite, of the Cambridge Polymer Group in Boston, MA, notes that hydrogels are hydrophilic, with the potential to contain 80% or more water, permeable and allowing solute transport. (medicalnewstoday.com)
  • Hydrogels have the capability to absorb large amounts of water or biological fluids into their three-dimensional hydrophilic polymer networks. (springer.com)
  • 9. A hydrogel comprising a crosslinked block copolymer, wherein said block copolymer comprises a poly(ring-opened cyclic ester-co-ring-opened ethylenically unsaturated epoxide)-block-(hydrophilic segment)-block-poly(ring-opened cyclic ester-co-ring-opened ethylenically unsaturated epoxide) copolymer, wherein the ring-opened ethylenically unsaturated epoxide is randomly distributed in the ring-opened cyclic ester portion of the block copolymer. (google.com.au)
  • 10. The hydrogel of claim 9 , wherein the hydrophilic segment is amphiphilic. (google.com.au)
  • 11. The hydrogel of claim 9 , wherein the hydrophilic segment comprises poly(ethylene glycol). (google.com.au)
  • 12. The hydrogel of claim 9 , wherein the hydrophilic segment comprises a hydroxy-terminated polyethylene oxide/polypropylene oxide block copolymer. (google.com.au)
  • 40. A hydrogel composition comprising a first portion which comprises a flexible plasticized hydrophilic polymer matrix having an internal cellular structure, and a second portion which comprises a flexible plasticized hydrophilic polymer matrix having relatively continuous internal structure. (freepatentsonline.com)
  • 43. A process for the preparation of a porous hydrogel, which comprises polymerising a polymerisable mixture comprising a hydrophilic monomer and optionally one or more comonomer, wherein the polymerisable mixture comprises a first portion including a relatively high concentration of introduced gas bubbles and a second portion including a relatively low concentration of gas bubbles. (freepatentsonline.com)
  • 44. A process according to claim 43, when used to prepare a hydrogel composition comprising a first portion which comprises a flexible plasticized hydrophilic polymer matrix having an internal cellular structure, and a second portion which comprises a flexible plasticized hydrophilic polymer matrix having relatively continuous internal structure. (freepatentsonline.com)
  • In this way, the book also addresses some of the fascinating properties and applications of polymeric hydrogels: they are three-dimensional, hydrophilic, polymeric networks that can absorb, swell and retain large quantities of water or aqueous fluids. (worldcat.org)
  • Hydrogels are semi-solid, gummy-bear-like squishy materials made of chains of hydrophilic polymer molecules. (popsci.com)
  • Hydrogels are a 3D network composed of hydrophilic polymer and have excellent swelling property which can absorb ten to thousand times of its dry weight in water. (medindia.net)
  • As the products of hydrogels are composed with a group of polymeric materials, the hydrophilic network structure makes them competent for holding an immense quantity of water in their three-dimensional polymer network structure. (scirp.org)
  • Perception of hydrogels has been established at the very beginning, as cross-linked 2-hydroxyethyl methacrylate (HEMA) hydrogels have been applied in numerous biomedical applications like carrier of drugs, sutures with absorbable capability, osteoporosis and as neoplasm because of their hydrophilic characters [3]. (scirp.org)
  • The properties of a hydrogel are highly dependent on the type and quantity of its crosslinks, making photopolymerization a popular choice for fine-tuning hydrogels. (wikipedia.org)
  • This chapter presents a novel fabrication method using a wet-spinning process that allows for the routine production of multifunctional coaxial hydrogel fibers that take advantage of the encapsulating properties of a hydrogel core while also promoting good cell growth and biocompatibility via the use of bio-friendly material in the sheath. (intechopen.com)
  • Synthetic hydrogels exhibit high water absorption capacities and proper mechanical strength, although their applications are being limited because of low biocompatibility and biodegradability as well as the toxicity arisen from unreacted monomers remained in the gel structure. (springer.com)
  • Protein-based hydrogels have substantial advantages such as biocompatibility, biodegradability, tunable mechanical properties, molecular binding abilities, and intelligent responses to external stimuli such as pH, ionic strength, and temperature. (springer.com)
  • Importantly, all hydrogels need to satisfy the basic requirements of biocompatibility in clinical use as well as possess unique physical and mechanical properties suited for skin wound applications. (wikipedia.org)
  • In addition, the biointerface of the fluorescent hydrogel with tissues requires excellent biocompatibility to reduce the occurrence of inflammation, which decreases the life span and functionality of an implantable glucose sensor. (pnas.org)
  • Hydrogel has high biocompatibility to the human eye, which means our bodies do not produce a negative immunological response when exposed to hydrogel. (lens.com)
  • They also have high biocompatibility to the human eye, which means people can wear hydrogel contact lenses without suffering any ill effects. (lens.com)
  • Environmentally sensitive hydrogels for drug delivery applications also require biocompatibility. (nih.gov)
  • In this method, photoinitiators, compounds that cleave from the absorption of photons, are added to the precursor solution which will become the hydrogel. (wikipedia.org)
  • A method as claimed in any one of the preceding claims wherein the ratio by volume of the hydrogel precursor solution to the coherent fibre structure is (20 to 70):1. (google.co.uk)
  • A kit of parts for producing a reinforced hydrogel product according to claims 11-12, the kit comprising a container of a hydrogel precursor solution (preferably sterilised) and a coherent fibrous structure (preferably sterilised), the fibres of the fibrous structure incorporating cations which are capable of cross-linking said hydrogel precursor to form a fibre reinforced hydrogel as the hydrogel product. (google.co.uk)
  • and wherein the hydrogel comprising composition is formed by injecting a hydrogel precursor solution into the aqueous solution or by co-extruding the hydrogel precursor solution in the aqueous solution. (epo.org)
  • The study found that the patients that did not receive SpaceOAR hydrogel experienced a clinically significant decline in bowel, urinary, and sexual quality of life eight times more often than patients that received SpaceOAR hydrogel. (prweb.com)
  • UNH researchers have created a hydrogel that could one day be made into a contact lens to more effectively treat corneal melting, a condition that is a significant cause for blindness world-wide. (unh.edu)
  • The end goal is to make the hydrogel into a contact lens that would allow more localized treatment of the eye and avoid side effects in the rest of the body. (unh.edu)
  • Researchers at the University of New Hampshire have created a hydrogel that could one day be made into a contact lens to treat corneal melting. (unh.edu)
  • 12. The contact lens of claim 2 wherein said polymerization product is a hydrogel. (google.com)
  • SiHy lenses offer high oxygen transmission, a number of cosmetic and comfort benefits, and are available in a wide range of prescriptions, all of which combine to recommend them as the standard contact lens material of choice over hydrogel. (coopervision.com)
  • Our experimentation will involve the study of biofilm formation and the ability of a non-steroidal anti-inflammatory drug, sodium salicylate, to retard or alter biofilm formation on a hydrogel contact lens. (nova.edu)
  • New information regarding the formulation for hydrogel contact lens design and disinfection systems may help to reduce the risk of infectious keratopathies. (nova.edu)
  • Because silicone hydrogel 1 Day lenses offer a healthy contact lens wearing experience 1 for patients' eyes. (coopervision.com)
  • Furthermore, not all contact lens wearers should wear silicone hydrogel contact lenses. (lens.com)
  • Hydrogel contact lenses also contain more water than their silicone hydrogel counterparts, making them ideal for contact lens wearers who suffer from dry eye syndrome. (lens.com)
  • 2. A shaped hydrogel according to claim 1 in the form of a contact lens in which the part overlying the iris of the eye is coloured and opaque and the part overlaying the pupil of the eye is transparent. (google.ca)
  • Consequently if an article such as a hydrogel contact lens is coloured in one of these ways, the effects obtainable are strictly limited. (google.ca)
  • Characterization methods for protein-based hydrogels are covered in the final section to determine rheological properties, morphology, and thermal stability. (springer.com)
  • 2. Characterization of the Cross-Linked Structure of Hydrogels. (routledge.com)
  • Hydrogels are highly absorbent (they can contain over 90% water) natural or synthetic polymeric networks. (wikipedia.org)
  • I thought you might be interested in this item at http://www.worldcat.org/oclc/932169743 Title: Polymeric hydrogels as smart biomaterials Author: Susheel Kalia Publisher: Cham : Springer, 2016. (worldcat.org)
  • This book is concerned with polymeric hydrogels, which are considered as one of the most promising types of new polymer-based materials. (worldcat.org)
  • It is needless to say that, polymeric hydrogels have great interests for biomaterial scientists for many years. (scirp.org)
  • The Brightening Infusion Hydrogel Mask contains galactomyces, vitamin C, and licorice extract to moisturize and brighten the skin complexion. (sephora.com)
  • This hydrogel mask has been developed for dehydrated, tired-looking skin. (ebay.com)
  • A hydrogel mask that contours the face to increase the look of elasticity and create a lifted appearance. (sephora.com)
  • All That Contours Hydrogel Expansion Stretch Mask perfectly fits your facial contours to give your face a lifted appearance. (sephora.com)
  • Erno Laszlo's 'Hydrogel Mask' soothes and calms sensitive skin - it's enriched with moisturizing Rose Oil, toning Honeysuckle Extract and renewing Skullcap Root. (net-a-porter.com)
  • The Lancôme Hydrogel Melting 360º Eye Mask contains the same amount of bifidus extract found in half a bottle of Advanced Génifique Yeux Light-Pearl (20 mL bottle). (neimanmarcus.com)
  • With a hydrogel melting texture, this eye mask works in just 20-minutes, leaving eyes feeling fresh and smoothed. (neimanmarcus.com)
  • MeTro (methacryloyl-substituted tropoelastin) is a highly elastic and adhesive surgical hydrogel that can seal wounds without the need for sutures. (youtube.com)
  • A method as claimed in any one of claims 1 to 5 wherein the hydrogel precursor incorporates an agent to stimulate the healing of wounds. (google.co.uk)
  • Rice researchers and collaborators at Texas Heart Institute (THI) have established a baseline set of injectable hydrogels that promise to help heal wounds, deliver drugs and treat cancer. (eurekalert.org)
  • The hydrogel is not only easy to synthesize, it can also be injected into the body to heal wounds or treat tumors infections. (medindia.net)
  • Our goal was to induce the growth of functional new blood vessels within the hydrogel to treat wounds and ischemic disease, which reduces blood flow to organs like the heart," Sun said. (redorbit.com)
  • Tegaderm Hydrogel Wound Filler may be used on infected wounds only under the care of a health care professional. (cvs.com)
  • In their study , recently published in the journal ACS Biomaterials Science & Engineering, the UNH researchers, along with researcher Jung-Jae Lee from the University of Colorado Denver Campus, outline how the hydrogel deactivates MMP-1, MMP-2 and MMP-9 which are the major factors in corneal melting. (unh.edu)
  • Nevertheless, recently hydrogel fibre based biomaterials have drawn great concentration for use in a wide variety of biomedical applications like the sustained release of drugs. (scirp.org)
  • That copolymer is subsequently crosslinked to form a hydrogel network. (google.com.au)
  • A method of producing a hydrogel product comprising impregnating a coherent fibrous structure with an aqueous solution of a hydrogel precursor material capable of being cross-linked to form a hydrogel, the fibres of the fibrous structure incorporating cations which are capable of cross-linking said precursor material to form a fibre reinforced hydrogel as the hydrogel product. (google.co.uk)
  • A method as claimed in any one of claims 1 to 3 wherein the hydrogel precursor consists wholly or partially of Ace Mannan (or other component of Alloe Vera). (google.co.uk)
  • A method as claimed in any one of the preceding claims wherein the hydrogel precursor is dissolved in a mixture of 75% to 85% by weight water and 15% to 25% by weight propylene glycol. (google.co.uk)
  • First Published in 1986, this book offers a full, comprehensive guide to the application of hydrogels in medicine. (routledge.com)
  • Special hydrogel formulation, with added aloe, balances viscosity and hydration. (medline.com)
  • Medela hydrogel pads have a special formulation that forms a protective cushion that cools skin on contact and supports healing. (medela.com)
  • The hydrogel solution is 97.5 per cent water, with the rest composed of polyacrylamide. (ehow.co.uk)
  • We found that the polyethylene glycol (PEG)-bonded polyacrylamide (PAM) hydrogel fibers reduced inflammation compared with PAM hydrogel fibers, transdermally glowed, and continuously responded to blood glucose concentration changes for up to 140 days, showing their potential application for long-term in vivo continuous glucose monitoring. (pnas.org)
  • Micrometre-sized silver flakes are suspended in a polyacrylamide-alginate hydrogel matrix and, after going through a partial dehydration process, the flakes form percolating networks that are electrically conductive and robust to mechanical deformations. (nature.com)
  • Thus, it was concluded that the claimed elasticity module and complex viscosity, which basically depended on the solid content of the hydrogel and on the structure of the polyacrylamide, were also fulfilled in document (4). (epo.org)
  • The researchers prepared a tough but stretchable conductive hydrogel containing polyaniline and polyacrylamide. (acs.org)
  • The hydrogel consists of polyacrylamide and a cross-linking agent (NOCCL), which forms net-like connections between the acrylamide molecules. (postech.ac.kr)
  • When the hydrogel and NO meet, the gaps in the polyacrylamide open and water flows in, increasing the mass by more than three times. (postech.ac.kr)
  • Advanced Urology Institute in Panama City, FL announces use of SpaceOAR hydrogel. (prweb.com)
  • SpaceOAR hydrogel acts as a protective spacer between the prostate and the rectum and has been clinically proven to reduce the risk of side effects from radiation treatment. (prweb.com)
  • SpaceOAR hydrogel is placed by Dr. Steven Eric Finkelstein M.D., FACRO, radiation oncologist and Dr. Michael Jenkins, M.D., a leading urologist at AUI. (prweb.com)
  • In April 2015, the Food and Drug Administration (FDA) cleared SpaceOAR hydrogel. (prweb.com)
  • What is SpaceOAR® Hydrogel? (nuffieldhealth.com)
  • What are the benefits of SpaceOAR® Hydrogel? (nuffieldhealth.com)
  • SpaceOAR® Hydrogel, a NICE approved water-based hydrogel spacing device, has recently been adopted by NHS England's Innovation Programme. (nuffieldhealth.com)
  • Is SpaceOAR® Hydrogel right for me? (nuffieldhealth.com)
  • What happens during SpaceOAR® Hydrogel treatment? (nuffieldhealth.com)
  • Please talk with your doctor about the risks and benefits associated with SpaceOAR Hydrogel. (nuffieldhealth.com)
  • Comprehensive Cancer Centers offers SpaceOAR hydrogel, an innovative product for men choosing to undergo radiation therapy for prostate cancer. (prweb.com)
  • We are excited to offer SpaceOAR hydrogel to our prostate cancer patients and believe it is in-line with our existing mission to provide the latest and most effective procedures. (prweb.com)
  • We're pleased that Comprehensive Cancer Centers sees the benefit of SpaceOAR hydrogel. (prweb.com)
  • Chitosan and Starch-Based Hydrogels via Graft Copolymerization. (worldcat.org)
  • Herein, hydrogels including alginate and chitosan are introduced and explained as follows. (intechopen.com)
  • To help prevent this, the researchers developed a new hydrogel that deactivates those enzymes by removing the zinc ions. (unh.edu)
  • A team of researchers at Harvard's Wyss Institute for Biologically Inspired Engineering, Brigham and Women's Hospital, the Mayo Clinic and MIT now describe a new class of hydrogel-based embolic agents, which could help eliminate all these caveats. (eurekalert.org)
  • The researchers wanted to know specifically how synthetic hydrogels influence the environment's inflammatory response. (eurekalert.org)
  • Prof. Hyung Joon Cha (Dept. of Chemical Engineering) and a team of researchers examined the behavior of sea anemone to create a mechanically durable hydrogel. (medindia.net)
  • Now, researchers have developed a stretchable conductive hydrogel that could someday be used to repair these types of nerves when there's damage. (acs.org)
  • Since the cell injections were successful in two different parts of the nervous system, researchers think the hydrogel would be effective in other parts of the body as well. (upi.com)
  • Researchers designed an injectable hydrogel that grew intestine-like tissues and accelerated wound healing in the intestines of mice. (nih.gov)
  • The researchers injected the hydrogel into wounded colons of mice. (nih.gov)
  • And in the unlikely event of the clear hydrogel pad turning cloudy or milky, dispose of it and use a fresh one. (medela.com)
  • Argyle™ neonatal tape is designed with our special clear hydrogel formula to gently yet firmly secure catheters, I.V. lines, lead wires and other medical devices to the fragile, sensitive skin of infants. (cardinalhealth.com)
  • The clear hydrogel also allows the patient's skin condition to be monitored without tape removal. (cardinalhealth.com)
  • with his synthetic peptide nanofiber scaffold, HydroMatrix offers the precision and control of a synthesized matrix with the natural three-dimensional architecture of highly crosslinked peptide hydrogel. (sigmaaldrich.com)
  • One-third of patients know about 1 Day silicone hydrogels 4 . (coopervision.com)
  • The invention provides absorbent hydrogel compositions and hydrogel-containing structures. (freepatentsonline.com)
  • c. mixing the degassed mixture to initiate grafting and polymerization to produce the absorbent hydrogel. (google.co.uk)
  • f) drying the washed hydrogel to form an absorbent hydrogel having a water uptake greater than a water uptake of the absorbent hydrogel before washing. (google.co.uk)
  • 15 . The method of claim 14 , wherein the absorbent hydrogel is a superabsorbent hydrogel. (google.co.uk)
  • The product is a synthetic hydrogel consisting primarily of water and iodinated cross-linked polyethylene glycol. (bostonherald.com)
  • Environmentally sensitive hydrogels have enormous potential in various applications. (nih.gov)
  • For this reason, either pH-sensitive and/or temperature-sensitive hydrogels can be used for site-specific controlled drug delivery. (nih.gov)
  • Light-sensitive, pressure-responsive and electro-sensitive hydrogels also have the potential to be used in drug delivery and bioseparation. (nih.gov)
  • While the concepts of these environment-sensitive hydrogels are sound, the practical applications require significant improvements in the hydrogel properties. (nih.gov)
  • The most significant weakness of all these external stimuli-sensitive hydrogels is that their response time is too slow. (nih.gov)
  • Development of environmentally sensitive hydrogels with such properties is a formidable challenge. (nih.gov)
  • The two-year study offered the first opportunity to test a variety of biocompatible hydrogels for the levels of inflammatory response they trigger. (eurekalert.org)
  • Body tissues and synthetic hydrogels have a lot in common, and the newest products have properties similar to body tissues, making them a good candidate for a growing range of medical applications. (medicalnewstoday.com)
  • Injectable through a fine needle, small hydrogel injections are clearly visible in the lung, breast, prostate and other tissues. (bostonherald.com)
  • But in the past 10 years, the field has made progress in creating successful three-dimensional cellular microenvironments with hydrogels-networks of interacting polymer chains that are highly hydrated, with elasticity similar to that of natural tissues. (sciencemag.org)
  • Specifically, myocardial tissues cultured on 50 μm thick CNT-GelMA showed 3 times higher spontaneous synchronous beating rates and 85% lower excitation threshold, compared to those cultured on pristine GelMA hydrogels. (nih.gov)
  • The photo-crosslinkable elastin-like polypeptide-based (ELP) hydrogel is activated using ultraviolet light, biocompatible and has characteristics similar to many soft tissues within the human body. (medindia.net)
  • The HydroMatrix scaffold self-assembles from fluid precursors into a highly cross-linked peptide 3-dimensional hydrogel in response to changes in temperature or ionic strength. (sigmaaldrich.com)
  • Through a photo-initiated dityrosine crosslinking method, the aneroin solution was transformed into a 3D hydrogel-based scaffold in a few seconds. (medindia.net)
  • Hydrogels are a synthetically made, flexible material that can also serve as a scaffold and may be safer for clinical use. (nih.gov)
  • The study led by chemist and bioengineer Jeffrey Hartgerink and graduate student Tania Lopez-Silva at Rice and Darren Woodside, vice president for research and director of the flow cytometry and imaging core at THI, demonstrates it should be possible to tune multidomain peptide hydrogels to produce appropriate inflammatory response for what they're treating. (eurekalert.org)
  • Generally speaking, a hydrogel according to the invention will comprise a coherent, three-dimensional aqueous polymer system capable of imbibing water without liquefying. (google.com.au)
  • More particularly, the present invention relates to the synthesis of biodegradable poly(α-hydroxy acid-co-glycidyl methacrylate)-block-poly(ethylene glycol)-block-poly(α-hydroxy acid-co-glycidyl methacrylate) copolymers, which are subsequently crosslinked to form hydrogel networks. (google.com.au)
  • The invention also relates to the use of these hydrogel networks in various applications, in particular, for the controlled release of drugs and proteins. (google.com.au)
  • The present invention relates to hydrogels, i.e. cross-linked macromolecular networks which are swollen with water or biological fluids. (google.co.uk)
  • The invention relates to colouring hydrogel objects to introduce colours desired for either protective masking or cosmetic purposes, and more particularly to colouring medical devices, such as ophthalmic contact lenses, for cosmetic or prosthetic reasons, or to protect the eyes from excessive light. (google.ca)
  • Methods for the manufacture or such hydrogels and structures are provided, as well as uses thereof. (freepatentsonline.com)
  • Using abundant tyrosine residues, tyrosine-tyrosine (dityrosine) interaction was promoted for a mechanically improved hydrogel because dityrosine-linkage contributes to durable structures in nature including the jumping pad of dragonflies and fertilization membranes of sea urchin. (medindia.net)
  • The new hydrogel matrix is highly stretchable, transparent and can sense temperatures at different locations on the skin. (medicalnewstoday.com)
  • Fig. 1: Soft, stretchable and electrically conductive hydrogel composite. (nature.com)
  • Stretchable hydrogel electronics and devices. (nature.com)
  • The resultant absorbent and superabsorbent hydrogels have high water uptake ratios, and can be utilized for a variety of applications. (google.co.uk)
  • Here, we present a long-term in vivo glucose monitoring method using glucose-responsive fluorescent hydrogel fibers. (pnas.org)
  • Hydrogels feature in various everyday products, from soft contact lenses and condoms to disposable diapers. (medicalnewstoday.com)
  • Most of these individuals are wearing hydrogel or soft contact lenses, which consist of a flexible plastic that contains anywhere from 36% to 74% water. (nova.edu)
  • The soft contact lenses available today are made of either hydrogel or silicone hydrogel . (lens.com)
  • Hoffman AS (2002) Hydrogels for biomedical applications. (springer.com)
  • In 2002, the US started marketing silicone hydrogel contact lenses. (lens.com)
  • Sharma K, Kaith BS, Kumar V, Kalia S, Kumar V, Swart HC (2014) Water retention and dye adsorption behavior of gg-cl-poly (acrylic acid-aniline) based conductive hydrogels. (springer.com)
  • Furthermore, efforts to increase conductivity by using hydrogel composites with conductive fillers have led to compromises in compliance and deformability. (nature.com)
  • As responsive "smart materials," hydrogels can encapsulate chemical systems which upon stimulation by external factors such as a change of pH may cause specific compounds such as glucose to be liberated to the environment, in most cases by a gel-sol transition to the liquid state. (wikipedia.org)
  • We fabricated glucose-responsive fluorescent hydrogels in a fibrous structure because this structure enables the sensors to remain at the implantation site for a long period. (pnas.org)
  • Hydrogels can easily swell and de-swell water in a reversible direction, showing specific environmental stimuli responsive for example pH, temperature and ionic potency. (scirp.org)
  • Hydrogels that are responsive to specific molecules, such as glucose or antigens, can be used as biosensors as well as drug delivery systems. (nih.gov)
  • If the achievements of the past can be extrapolated into the future, however, it is highly likely that responsive hydrogels with a wide array of desirable properties can be made. (nih.gov)
  • A new hydrogel that is responsive to nitric oxide (NO) could help treat rheumatoid arthritis by absorbing synovial liquid, according to a new study. (postech.ac.kr)
  • Republic of Korea), the hydrogel rapidly swells in response to NO, and is subsequently converted to an enzyme-responsive gel by cascade reactions. (postech.ac.kr)
  • HOUSTON - (Dec. 16, 2019) - Hydrogels for healing, synthesized from the molecules up by Rice University bioengineers, are a few steps closer to the clinic. (eurekalert.org)
  • It is widely accepted that hydrogel surfaces are slippery, and have low friction, but dynamic applied stresses alter the hydrogel composition at the interface as water is displaced. (rsc.org)
  • 4. Hydrogel Surfaces. (routledge.com)
  • Hydrogels derived from central nervous system extracellular matrix. (nih.gov)
  • Hydrogels have also been used as coatings for various biomedical applications. (google.com.au)
  • For that reason, smart physiological response of hydrogels toward changes of physiological variable suggests their use in various biomedical applications [2]. (scirp.org)
  • In December 2015, the MIT team announced the creation of a set of "tough hydrogels" containing 70-95% water, with "extraordinary mechanical properties. (medicalnewstoday.com)
  • The objectives of the present study were to develop hydrogel forms of brain and spinal cord ECM and compare the resulting biochemical composition, mechanical properties, and neurotrophic potential of a brain derived cell line to a non-CNS-ECM hydrogel, urinary bladder matrix. (nih.gov)
  • Protein can be converted to hydrogel using physical, chemical, or enzymatic treatments. (springer.com)
  • This chapter intends to look over protein-based hydrogels. (springer.com)
  • After brief introduction of protein and its structure, the properties of proteins and peptides used to develop hydrogels, as well as their preparation methods are discussed. (springer.com)
  • Fisher SA, Baker AE, Shoichet MS (2017) Designing peptide and protein modified hydrogels: selecting the optimal conjugation strategy. (springer.com)
  • 14 . The spinal implant as set forth in claim 1 , wherein the implant material is selected from the group consisting of a hydrogel, a cross-linked protein and a polyurethane. (google.com)
  • Because it is a not a biological extract, it provide a better control of the composition of cells' environment: control over growth factor incorporation, attachment factor incorporation, ECM protein incorporation, rigidity of the hydrogel. (sigmaaldrich.com)
  • Absorbent hydrogels are formed by reacting a protein meal base, a radical initiator and a polymerizable monomer. (google.co.uk)
  • 6. Protein Absorption to Hydrogels. (routledge.com)