A thiazide diuretic often considered the prototypical member of this class. It reduces the reabsorption of electrolytes from the renal tubules. This results in increased excretion of water and electrolytes, including sodium, potassium, chloride, and magnesium. It is used in the treatment of several disorders including edema, hypertension, diabetes insipidus, and hypoparathyroidism.
Sodium Chloride Symporter Inhibitors
Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS.
A long-acting dihydropyridine calcium channel blocker. It is effective in the treatment of ANGINA PECTORIS and HYPERTENSION.
Drug Therapy, Combination
Angiotensin II Type 1 Receptor Blockers
A potent and specific inhibitor of PEPTIDYL-DIPEPTIDASE A. It blocks the conversion of ANGIOTENSIN I to ANGIOTENSIN II, a vasoconstrictor and important regulator of arterial blood pressure. Captopril acts to suppress the RENIN-ANGIOTENSIN SYSTEM and inhibits pressure responses to exogenous angiotensin.
An angiotensin-converting enzyme inhibitor that is used to treat HYPERTENSION and HEART FAILURE.
Compounds with a BENZENE fused to IMIDAZOLES.
A benzamide-sulfonamide-indole derived DIURETIC that functions by inhibiting SODIUM CHLORIDE SYMPORTERS.
Sodium Chloride Symporters
A subclass of symporters found in KIDNEY TUBULES, DISTAL that are the major pathway for salt resorption. Inhibition of these symporters by BENZOTHIADIAZINES is the basis of action of some DIURETICS.
A phosphinic acid-containing angiotensin-converting enzyme inhibitor that is effective in the treatment of hypertension. It is a prodrug that is converted to its active metabolite fosinoprilat.
Heterocyclic compounds with SULFUR and NITROGEN in the ring. This term commonly refers to the BENZOTHIADIAZINES that inhibit SODIUM-POTASSIUM-CHLORIDE SYMPORTERS and are used as DIURETICS.
A thiazide diuretic with actions and uses similar to those of HYDROCHLOROTHIAZIDE. It has been used in the treatment of familial hyperkalemia, hypertension, edema, and urinary tract disorders. (From Martindale, The Extra Pharmacopoeia, 30th ed, p810)
Blood Pressure Monitoring, Ambulatory
A compound that inhibits symport of sodium, potassium, and chloride primarily in the ascending limb of Henle, but also in the proximal and distal tubules. This pharmacological action results in excretion of these ions, increased urinary output, and reduction in extracellular fluid. This compound has been classified as a loop or high ceiling diuretic.
Angiotensin-Converting Enzyme Inhibitors
A class of drugs whose main indications are the treatment of hypertension and heart failure. They exert their hemodynamic effect mainly by inhibiting the renin-angiotensin system. They also modulate sympathetic nervous system activity and increase prostaglandin synthesis. They cause mainly vasodilation and mild natriuresis without affecting heart rate and contractility.
A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827)
A highly specific (Leu-Leu) endopeptidase that generates ANGIOTENSIN I from its precursor ANGIOTENSINOGEN, leading to a cascade of reactions which elevate BLOOD PRESSURE and increase sodium retention by the kidney in the RENIN-ANGIOTENSIN SYSTEM. The enzyme was formerly listed as EC 220.127.116.11.
A pyrazine compound inhibiting SODIUM reabsorption through SODIUM CHANNELS in renal EPITHELIAL CELLS. This inhibition creates a negative potential in the luminal membranes of principal cells, located in the distal convoluted tubule and collecting duct. Negative potential reduces secretion of potassium and hydrogen ions. Amiloride is used in conjunction with DIURETICS to spare POTASSIUM loss. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p705)
Solute Carrier Family 12, Member 3
Na-Cl cotransporter in the convoluted segments of the DISTAL KIDNEY TUBULE. It mediates active reabsorption of sodium and chloride and is inhibited by THIAZIDE DIURETICS.
Abnormally low potassium concentration in the blood. It may result from potassium loss by renal secretion or by the gastrointestinal route, as by vomiting or diarrhea. It may be manifested clinically by neuromuscular disorders ranging from weakness to paralysis, by electrocardiographic abnormalities (depression of the T wave and elevation of the U wave), by renal disease, and by gastrointestinal disorders. (Dorland, 27th ed)
An element in the alkali group of metals with an atomic symbol K, atomic number 19, and atomic weight 39.10. It is the chief cation in the intracellular fluid of muscle and other cells. Potassium ion is a strong electrolyte that plays a significant role in the regulation of fluid volume and maintenance of the WATER-ELECTROLYTE BALANCE.
Gout suppressants that act directly on the renal tubule to increase the excretion of uric acid, thus reducing its concentrations in plasma.
A selective adrenergic beta-1 blocking agent that is commonly used to treat ANGINA PECTORIS; HYPERTENSION; and CARDIAC ARRHYTHMIAS.
Calcium Channel Blockers
A calcium channel blocker with marked vasodilator action. It is an effective antihypertensive agent and differs from other calcium channel blockers in that it does not reduce glomerular filtration rate and is mildly natriuretic, rather than sodium retentive.
A potent antagonist of CALCIUM CHANNELS that is highly selective for VASCULAR SMOOTH MUSCLE. It is effective in the treatment of chronic stable angina pectoris, hypertension, and congestive cardiac failure.
Low-dose combination therapy as first-line hypertension treatment for blacks and nonblacks. (1/504)To assess the efficacy and safety of bisoprolol/6.25-mg hydrochlorothiazide (HCTZ), amlodipine, and enalapril in black and nonblack patients, data from two comparative studies were pooled and subgroup analyses performed. Both studies had similar designs and included all three active treatments. The second study also included a placebo group. Subjects (n = 541) with a sitting diastolic blood pressure of 95-114 mmHg were titrated to achieve a diastolic blood pressure < or = 90 mmHg. The studies included 114 blacks and 427 nonblacks. Results of an intention-to-treat analysis of mean change from baseline after 12 weeks of treatment showed the following: 1) blood pressure was significantly lowered by all three active drugs compared with baseline or placebo; 2) in blacks, bisoprolol/6.25-mg HCTZ resulted in significantly greater reductions of systolic and diastolic blood pressure than enalapril or placebo, but was not significantly different from amlodipine; 3) in nonblacks, bisoprolol/6.25-mg HCTZ resulted in significantly greater reduction of diastolic blood pressure than amlodipine, enalapril, or placebo. The placebo-corrected change in blood pressure was greater for blacks than whites on the bisoprolol/6.25-mg HCTZ combination, but this was not statistically significant. Bisoprolol/6.25-mg HCTZ controlled diastolic blood pressure to < or = 90 mmHg in significantly more patients than enalapril or placebo in blacks and nonblacks. The difference in control rates was not significant versus amlodipine. The incidence of drug-related adverse events was similar between treatments; however, bisoprolol/6.25-mg HCTZ had a lower discontinuation rate due to lack of blood pressure control or adverse experiences in both blacks and nonblacks. (+info)
Drug-induced hyponatraemia in psychogenic polydipsia. (2/504)Two patients with psychogenic polydipsia developed hyponatraemia, one in association with administration of hydrochlorothiazide and the other with that of tolbutamide. It is suggested that the increased fluid intake in such patients may make them more susceptible to the development of hyponatraemia from thiazide or sulphonylurea compounds. (+info)
Inhibition of carbonic anhydrase accounts for the direct vascular effects of hydrochlorothiazide. (3/504)Hydrochlorothiazide has been shown to exert direct vasodilator effects by activation of calcium-activated potassium (KCa) channels in human and guinea pig isolated resistance arteries. Since hydrochlorothiazide binds to and inhibits the enzyme carbonic anhydrase and because KCa channel activation is pH sensitive, we investigated the role of intracellular and extracellular carbonic anhydrase in the vascular effects of thiazide diuretics. Small arteries were isolated from guinea pig mesentery and studied by use of a microvascular myograph technique. In some experiments, tone and intracellular pH (pHi) were measured simultaneously with 2', 7'-bis(2-carboxyethyl)-5(6)'-carboxyfluorescein (BCECF-AM). Bendroflumethiazide, a thiazide diuretic with minimal inhibitory effects on carbonic anhydrase, had little effect on noradrenaline-induced tone (16+/-8% relaxation) compared with hydrochlorothiazide (74+/-12% relaxation). In contrast to hydrochlorothiazide, the action of bendroflumethiazide was unaffected by 100 nmol/L charybdotoxin, a selective blocker of KCa channels. All inhibitors of carbonic anhydrase relaxed noradrenaline-induced tone in a concentration-dependent manner, and this effect was blocked by charybdotoxin. Hydrochlorothiazide and the inhibitors of carbonic anhydrase failed to relax tone induced by a depolarizing potassium solution. Acetazolamide and hydrochlorothiazide increased pHi by 0.27+/-0.07 and 0.21+/-0.04, respectively, whereas bendroflumethiazide had a much smaller effect: 0.06+/-0.03. The rise in pHi induced by any agent was not inhibited by charybdotoxin. The vasorelaxant effect of hydrochlorothiazide is shared by other inhibitors of carbonic anhydrase. Inhibitors of carbonic anhydrase, but not bendroflumethiazide, cause intracellular alkalinization, which is associated with KCa channel opening. These data suggest that the vasodilator effect of thiazide diuretics results primarily from inhibition of vascular smooth muscle cell carbonic anhydrase, which results in a rise in pHI, leading to KCa channel activation and vasorelaxation. (+info)
Treatment of nephrogenic diabetes insipidus with hydrochlorothiazide and amiloride. (4/504)Nephrogenic diabetes insipidus (NDI) is characterised by the inability of the kidney to concentrate urine in response to arginine vasopressin. The consequences are severe polyuria and polydipsia, often associated with hypertonic dehydration. Intracerebral calcification, seizures, psychosomatic retardation, hydronephrosis, and hydroureters are its sequelae. In this study, four children with NDI were treated with 3 mg/kg/day hydrochlorothiazide and 0.3 mg/kg/day amiloride orally three times a day for up to five years. While undergoing treatment, none of the patients had signs of dehydration or electrolyte imbalance, all showed normal body growth, and there was no evidence of cerebral calcification or seizures. All but one had normal psychomotor development and normal sonography of the urinary tract. However, normal fluid balance was not attainable (fluid intake, 3.8-7.7 l/m2/day; urine output, 2.2-7.4 l/m2/day). The treatment was well tolerated and no side effects could be detected. Prolonged treatment with hydrochlorothiazide/amiloride appears to be more effective and better tolerated than just hydrochlorothiazide. Its efficacy appears to be similar to that of hydrochlorothiazide/indomethacin but without their severe side effects. (+info)
Regulation of 11beta-hydroxysteroid dehydrogenase type 2 by diuretics and the renin-angiotensin-aldosterone axis. (5/504)In the kidney and colon 11beta-hydroxysteroid dehydrogenase type 2 (11beta-HSD2) inactivates cortisol to cortisone, thereby protecting the non-selective mineralocorticoid receptor from cortisol. Deficiency of 11beta-HSD2 results in cortisol-mediated sodium retention and hypertension, suggesting that the physiological regulation of 11beta-HSD2 in mineralocorticoid target tissues may be important in modulating sodium homoeostasis and blood pressure control. Using the human epithelial colon cell line SW-620, reverse transcriptase-polymerase chain reaction and enzyme kinetic analysis indicated expression of only 11beta-HSD2 (Km for cortisol 66 nmol/l). Bradykinin (10(-8) to 10(-12) mol/l), frusemide (10(-4) to 10(-9) mol/l), benzamiloride hydrochloride (10(-5) to 10(-10) mol/l) and atrial natriuretic peptide (10(-6) to 10(-10) mol/l) had no effect on 11beta-HSD2 expression. Using a range of concentrations of angiotensin II (2x10(-8) to 2x10(-5) mol/l) a significant reduction in activity was seen but only at supra-physiological concentrations, [e.g. 2x10(-6) mol/l at 4 h pretreatment: 36.7+/-2.0 pmol cortisone. h-1.mg-1 (mean+/-S.E.M.) compared with 45.1+/-1.7 pmol.h-1.mg-1 in control; P<0.05]. The angiotensin-converting enzyme inhibitors captopril, enalapril, lisinopril, perindopril, quinapril and trandolapril at 10(-7) mol/l, but not fosinopril, significantly increased 11beta-HSD2 activity after pretreatment for 16 or 24 h (P<0.05-P<0.01 compared with control). No effects were seen at 4 h pretreatment. Hydrochlorothiazide (10(-7) mol/l) significantly decreased 11beta-HSD2 activity (P<0.05 compared with control) at 4 h pretreatment. Commonly used diuretics, atrial natriuretic peptide and physiological concentrations of angiotensin II and bradykinin do not alter 11beta-HSD2 activity. In contrast, a series of angiotensin-converting enzyme inhibitors significantly increase 11beta-HSD2 activity in vitro. This may explain how intrarenal infusions of angiotensin-converting enzyme inhibitors increase renal sodium excretion independent of circulating concentrations of angiotensin II. The interaction between angiotensin-converting enzyme inhibitors and 11beta-HSD2 may be an additional mechanism by which the former can lower blood pressure. (+info)
Optimization of urinary FDG excretion during PET imaging. (6/504)Accumulation of fluorodeoxyglucose (FDG) activity in the urine interferes with the visualization of pelvic and, sometimes, abdominal abnormalities. Although this is a major problem, there are few data on the physiological variables affecting FDG urinary excretion that are critical to minimizing urinary FDG interference during PET imaging. METHODS: The excretion of FDG in urine was determined during 90 min in four groups of rats (n = 24) under the following conditions: normal, hydrated, hydrochlorothiazide treated and phlorizin treated. FDG clearance rates were measured in both normal and phlorizin-treated animals and compared with the glomeruler filtration rate measured with 99mTc-diethylenetriamine pentaacetic acid. We measured FDG excretion in 10 patients who had no known renal disease and were undergoing PET scanning (divided into two groups: hydrated and dehydrated) to relate the animal data to humans. RESULTS: The hydrated and phlorizin-treated animals had the highest excretion of FDG (39.68+/-5.00 % injected dose (%ID) and 45.64+/-9.77 %ID, respectively). Animals given the hydrochlorothiazide had the highest urinary volume, but the percentage excreted was comparable with the normal rats. Measurement of the clearance of FDG in animals before and after the administration of phlorizin determined the amount of FDG reabsorbed in the proximal tubules to be 56%+/-9.15%. The hydrated patients had a higher excretion of FDG than dehydrated patients (16.98+/-1.99 %ID versus 14.27+/-1.00 %ID, P < 0.021), and the volume of urine voided was significantly higher (P < 0.020). CONCLUSION: Hydrochlorothiazide increases urine volume without enhancing FDG excretion. The hydration of patients before PET scanning may lead to more FDG reaching the bladder. Reduction of bladder activity by more frequent voiding facilitated by increased urine volume in hydrated patients may be offset by increased delivery of FDG to the bladder. A preferable means of increasing urinary volume without increasing delivery of FDG to the bladder may be the use of a diuretic. (+info)
Effects of aging and antihypertensive treatment on aortic internal diameter in spontaneously hypertensive rats. (7/504)The effect of antihypertensive treatment on the development of large-artery remodeling in young animals has been widely studied, but reversal of established changes in older hypertensive animals has been largely ignored, although the latter represents a better paradigm for the human condition. We studied the effect of treatment with captopril plus hydrochlorothiazide, from 3 months onward, on geometry and wall stress of the thoracic aorta of adult (9 months, maturation) and old (15 months, senescence) spontaneously hypertensive rats; normotensive Wistar-Kyoto rats were used as controls. At 3 months of age, blood pressure, medial cross-sectional area, and internal diameter were higher in spontaneously hypertensive rats than in Wistar-Kyoto rats. In both strains, medial cross-sectional area and lumen diameter increased during maturation; there was little change with senescence. Changes in blood pressure were minor. Because medial hypertrophy failed to compensate for the wider lumen and higher intraluminal pressure in spontaneously hypertensive rats, medial stress was higher in these rats than in Wistar-Kyoto rats. Captopril plus hydrochlorothiazide rapidly lowered blood pressure and medial cross-sectional area. Despite a marked fall in blood pressure, the internal diameter of the thoracic aorta of treated animals was similar to that of untreated animals after 6 months of treatment and started to fall only after the animals had been treated for 1 year. Thus, under treatment with captopril plus hydrochlorothiazide, medial stress remained elevated, even after very-long-term treatment, because medial cross-sectional area was not adapted to internal diameter. We suggest that some changes in large-artery structure associated with hypertension and aging, such as the increase in diameter, take considerable time to regress after blood pressure is lowered, and this may explain why, despite treatment, wall stress remains elevated. (+info)
Fosinopril/hydrochlorothiazide: single dose and steady-state pharmacokinetics and pharmacodynamics. (8/504)AIMS: Fosinoprilat, the active product of fosinopril, is eliminated by an hepatic pathway in addition to the renal pathway shared by other angiotensin converting enzyme inhibitors (ACEIs). This study aimed to determine whether impaired renal function affects the pharmacokinetics and pharmacodynamics of a combination of fosinopril and hydrochlorothiazide (HCTZ). METHODS: The study had a parallel-group design comparing patients with renal impairment and body-mass-index-matched normal controls. The study was done in a University clinic in 13 patients with renal impairment (mean creatinine clearance 55.7+/-15.6 ml min-1 1.73 m-2 ) and 13 age-, sex-, and body-mass-index-matched normal controls (mean creatinine clearance 102.4+/-8.9 ml min-1 1.73 m-2 ). All patients and normal controls received fosinopril sodium 20 mg and HCTZ 12.5 mg as a daily oral administration on days 1-5. Non-compartmental pharmacokinetic parameters of fosinoprilat and HCTZ were determined from blood and urine samples obtained over 48 h starting on Day 1 (single dose) and Day 5 (steady state): maximum serum concentration (Cmax ), time to maximum serum concentration (tmax ), area under the serum concentration-time curve during the dosing interval (AUC), cumulative urinary excretion (CUE) and the accumulation index (AI; ratio of AUC-day 5/AUC-day 1). Pharmacodynamic parameters were also measured over 24 h on day 1 and over 48 h on day 5: serum ACE activity and arterial blood pressure. RESULTS: Fosinoprilat pharmacokinetic parameters on day 1 in renally impaired vs normal patients: Cmax=387+/-0.19 vs 324+/-0.25 ng ml-1 (P=0.07); tmax=3.5 vs 3.0 h (P=0.58); AUC=3510+/-0.29 vs 2701+/-0.35 ng ml-1 h (P=0. 072); CUE=5.08+/-2.70 vs 7.40+/-2.56% (P=0.009). Fosinoprilat parameters on day 5: Cmax=517+/-0.40 vs 357+/-0.19 ng ml-1 (P=0. 007); tmax=3.0 vs 3.0 h (P >0.99); AUC=4098+/-0.43 vs 2872+/-0.30 ng ml-1 h (P=0.027); CUE=6.81+/-3.53 vs 8.10+/-2.80% (P=0.068). AI=1. 17+/-0.33 vs 1.06+/-0.23 (P=0.29). In both groups ACE inhibition and blood pressure response were similar over 24 h and slightly greater 48 h after last dosing. CONCLUSIONS: In renally impaired subjects fosinopril and HCTZ can be coadministered without undue increases in fosinoprilat concentrations or any clinically significant pharmacodynamic effects. This is probably due to the dual excretory pathways for fosinoprilat. (+info)
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Using this medicine while you are pregnant can harm your unborn baby. Use an effective form of birth control to keep from getting pregnant. If you think you have become pregnant while using this medicine, tell your doctor right away. This medicine may cause dizziness, lightheadedness, or fainting, especially when you get up suddenly from a lying or sitting position. Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you are dizzy. If you feel dizzy, lie down so you do not faint. Then sit for a few moments before standing to prevent the dizziness from returning. If you faint, call your doctor right away. Check with your doctor right away if you become sick while taking this medicine, especially if you have severe nausea, vomiting, or diarrhea that does not stop. These conditions may cause you to lose too much water and lead to low blood pressure. You can also lose water by sweating, so drink plenty ...
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No se debe utilizar esta información para decidir si se debe tomar este medicamento o cualquier otro. Solamente el proveedor de atención médica tiene el conocimiento y la capacitación para decidir qué medicamentos son adecuados para un paciente específico. Esta información no recomienda ningún medicamento como seguro, eficaz o aprobado para tratar a ningún paciente o enfermedad. Es solamente un breve resumen de información general sobre este medicamento. NO incluye toda la información sobre los usos, las instrucciones, las advertencias, las precauciones, las interacciones, los efectos secundarios o los riegos posibles que podrían aplicarse a este medicamento. Esta información no constituye asesoramiento médico específico y no reemplaza la información que usted recibe de su proveedor de atención médica. Debe hablar con el proveedor de atención médica para obtener información completa sobre los riesgos y los beneficios de tomar este medicamento.. ...
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- Customers can order Losartan/Hydrochlorothiazide through our online online prescription service and we offer both the branded and the generic formulation of this medication. (hiras.com)
- This medication contains a combination of hydrochlorothiazide and losartan. (hiras.com)
- This medication is used to lower blood pressure and to decrease edema (swelling) Losartan Potssium/ Hydrochlorothiazide is used in the treatment of hypertension, heart failure, heart attack and diabetic kidney disease. (horisont.ee)
- When Ampicillin for Injection, hydrochlorothiazide drug use USP is prescribed to treat a bacterial infection, patients should be told that although it is common to feel better early in the course of therapy, the medication should be taken exactly as directed? (fmocltd.com)
- Amlodipine, hydrochlorothiazide, and olmesartan may also be used for purposes not listed in this medication guide. (many-cheap-pills.com)
- The reaction is neutralized with Na 2CO 3 (8 grams) and 40ml of ramipril hydrochlorothiazide combination and the aqueous layer is extracted 3x with 100ml of N-butanol? (newmossrecords.com)
- I am taking hydrochlorothiazide for water retention, and I'm still swollen microzide my microzide, feet, microzide, and legs. (alfordhighschool.com)
- Hydrochlorothiazide will increase urination so it is recommended to take it in the morning to microzide the amount of time spent getting up at night to urinate. (alfordhighschool.com)
- Consult your urologist to find out the specific reason that hydrochlorothiazide microzide stopped. (alfordhighschool.com)
- Common side effects of hydrochlorothiazide include frequent urination, weakness, and microzide. (alfordhighschool.com)
- Hydrochlorothiazide and enalapril is a combination medicine used to treat hypertension (high blood pressure). (wellspan.org)
- If you are diagnosed with hypertension, also known as high blood pressure, your doctor may prescribe Diovan HCT or generic Valsartan/Hydrochlorothiazide. (discountdrugsfromcanada.com)
- Losartan+Amlodipine+Hydrochlorothiazide is used in the treatment of hypertension . (1mg.com)
- Parati, G , Bilo, G & Redon, J 2013, ' The effects of telmisartan alone or with hydrochlorothiazide on morning and 24-h ambulatory BP control: Results from a practice-based study (SURGE 2) ', Hypertension Research , vol. 36, no. 4, pp. 322-327. (elsevier.com)
- What is the most important information I should know about hydrochlorothiazide and enalapril? (wellspan.org)
- Do not take hydrochlorothiazide and enalapril within 36 hours before or after taking medicine that contains sacubitril (such as Entresto). (wellspan.org)
- What should I discuss with my healthcare provider before taking hydrochlorothiazide and enalapril? (wellspan.org)
- How should I take hydrochlorothiazide and enalapril? (wellspan.org)
- Zoloft hydrochlorothiazide food-drug interactions specifically on your neurotransmitters. (newmossrecords.com)
Price in india4
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- 1. The antidiuretic effect of hydrochlorothiazide in diabetes insipidus was investigated in rats with the hereditary hypothalamic form of the disease (Brattleboro rats). (portlandpress.com)
- Mocrozide suggest that hydrochlorothiazide which is a water pill is generally well-tolerated but can occassionally increase blood sugar microzire patients with a history of diabetes. (alfordhighschool.com)
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- Lisinopril/Hydrochlorothiazide Prescription Discount Card, Coupons, and Patient Assistance Programs. (discountdrugnetwork.com)
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- Certain strains of hydrochlorothiazide interaction with zyrtec target species, for example staphylococci, secrete the enzyme penicillinase, which inactivates penicillin and confers resistance to the antibiotic. (newmossrecords.com)
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- What are the side effects of hydrochlorothiazide? (alfordhighschool.com)
- Mirozide are hydrochlorothiazide side effects? (alfordhighschool.com)
- Some of the side effects that may microzixe seen with hydrochlorothiazide include: Ask your doctor or pharmacist for more information. (alfordhighschool.com)
- Lisinopril is anti-htn medicine hydrochlorothiazide side effects hives an ace inhibitor. (newmossrecords.com)
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- When used to treat edema, hydrochlorothiazide may be taken daily or only on certain days of the week. (medlineplus.gov)
- Hydrochlorothiazide tablets are indicated as adjunctive therapy in edema associated with congestive heart failure, hepatic cirrhosis, and corticosteroid and estrogen therapy. (nih.gov)
- Hydrochlorothiazide tablets have also been found useful in edema due to various forms of renal dysfunction such as nephrotic syndrome, acute glomerulonephritis, and chronic renal failure. (nih.gov)
- Hydrochlorothiazide treats fluid retention (edema) in people with congestive heart failure, cirrhosis of the liver, or kidney disorders, or edema caused by taking steroids or estrogen. (cardiosmart.org)
- The combination of hydrochlorothiazide and spironolactone is used to treat fluid retention (edema) in people with congestive heart failure, cirrhosis of the liver, or a kidney disorder called nephrotic syndrome. (cardiosmart.org)
- In some cases, hydrochlorothiazide is used to treat edema or high blood pressure in children. (sharecare.com)
- To reduce fluid retention (edema), the usual recommended adult dose of hydrochlorothiazide is 25 mg to 200 mg daily. (medbroadcast.com)
- Hydrochlorothiazide may be used to relieve edema and in the treatment of high blood pressure but may not be suitable for some people including those with sulfonamide allergies. (bingj.com)
- Hydrochlorothiazide reduces the swelling of hands or feet (edema), as well as water retention in people with liver disease, kidney disease, and congestive heart failure. (internationaldrugmart.com)
- Drug interactions to be aware of include lithium, agents increasing serum levels of potassium, and the use of hydrochlorothiazide with antidiabetic drugs both oral agents and insulin. (wikipedia.org)
- Hydrochlorothiazide is supplied as 25 mg and 50 mg tablets for oral use. (nih.gov)
- AVALIDE is available for oral administration in film-coated tablets containing either 150 mg or 300 mg of irbesartan combined with 12.5 mg of hydrochlorothiazide. (rxlist.com)
- Each capsule of DYAZIDE (hydrochlorothiazide and triamterene) for oral use, with opaque red cap and opaque white body, contains hydrochlorothiazide 25 mg and triamterene 37.5 mg, and is imprinted with the product name DYAZIDE and SB. (bioportfolio.com)
- However, giving oral potassium pills along with thiazide diuretics negates the cost savings of hydrochlorothiazide over other diuretics. (livestrong.com)
- Oral jelly in normaler apotheke oral jelly johannesburg oral jelly over the counter wo super kaufen place clichy where to get hydrochlorothiazide . (xochiquetzal.nl)
- Hydrochlorothiazide belongs to a class of drugs called thiazide diuretics. (healthline.com)
- Amizide contains a combination of two diuretics, amiloride hydrochloride and hydrochlorothiazide as the active ingredients. (news-medical.net)
- Hydrochlorothiazide belongs to the class of medicines known as thiazide diuretics. (bingj.com)
Effects of hydrochlorothiazide7
- The effects of hydrochlorothiazide indirectly lower the levels of serum potassium. (wikipedia.org)
- Nonsteroidal anti-inflammatory drugs, for example, ibuprofen, may reduce the blood pressure effects of hydrochlorothiazide. (medicinenet.com)
- Avoid drinking alcohol, which can increase some of the side effects of hydrochlorothiazide. (cardiosmart.org)
- What are the possible side effects of hydrochlorothiazide and methyldopa (Aldoril 15, Aldoril 25)? (rxlist.com)
- There are several common side effects of hydrochlorothiazide, a type of drug also called a thiazide diuretic, or water pill. (wisegeek.com)
- Drinking alcohol can increase certain side effects of hydrochlorothiazide and spironolactone. (cardiosmart.org)
- The diuretic and blood pressure lowering effects of hydrochlorothiazide may last six to 12 hours. (bingj.com)
Interact with hydrochlorothiazide5
- There are many other drugs that can interact with hydrochlorothiazide. (cardiosmart.org)
- Grapefruit does not interact with hydrochlorothiazide. (livestrong.com)
- Although grapefruit can be dangerous if it interacts with some medications, it does not appear to interact with hydrochlorothiazide, a diuretic often used to treat high blood pressure. (livestrong.com)
- Other drugs may interact with hydrochlorothiazide and moexipril, including prescription and over-the-counter medicines, vitamins, and herbal products. (everydayhealth.com)
- Medicines that interact with hydrochlorothiazide may either decrease its effect, affect how long it works for, increase side effects, or have less of an effect when taken with hydrochlorothiazide. (bingj.com)
- tell your doctor and pharmacist if you are allergic to hydrochlorothiazide, 'sulfa drugs', penicillin, or any other drugs. (medlineplus.gov)
- Which drugs or supplements interact with valsartan/hydrochlorothiazide? (medicinenet.com)
- Valsartan/hydrochlorothiazide should be used with caution with nonsteroidal anti-inflammatory drugs ( NSAIDs ) like naproxen ( Naprosyn ), ibuprofen ( Motrin ), meloxicam ( Mobic ), and celecoxib ( Celebrex ) because they can worsen kidney function and lower water removing effects of valsartan/hydrochlorothiazide. (medicinenet.com)
- Captopril/hydrochlorothiazide is a combination of two drugs in a single form that work in different ways to treat high blood pressure. (healthline.com)
- Captopril/hydrochlorothiazide is a combination of two drugs in a single form. (healthline.com)
- Digoxin , lithium and non-steroidal anti-inflammatory drugs ( NSAIDs ) are just some of the drugs that might interfere with hydrochlorothiazide. (wisegeek.com)
- These drugs are collectively referred to as Generic Microzide based on the brand name or Generic Hydrochlorothiazide coming from the name of the active substance used in the medications. (rxshop.md)
- They prescribed effect for 10 medicines to hydrochlorothiazide and lisinopril loosen differences up so i can take nonparametric drugs. (duvalia.com)
- Aldosterone: renal drugs can potentiate the hydrochlorothiazide and lisinopril atrial nitrates of sale reason herbs. (duvalia.com)
- Hyzaar is the brand name of a combination medicine that contains the drugs losartan and hydrochlorothiazide . (everydayhealth.com)
- Had history of allergy or hypersensitivity to hydrochlorothiazide or any other sulphonamide derived drugs. (clinicaltrials.gov)
- What is valsartan/hydrochlorothiazide? (medicinenet.com)
- Valsartan / hydrochlorothiazide is a combination of two medications that is used to treat high blood pressure and congestive heart failure . (medicinenet.com)
- The combination of valsartan and hydrochlorothiazide reduces blood pressure more that either drug alone. (medicinenet.com)
- The FDA approved valsartan/hydrochlorothiazide in March 1998. (medicinenet.com)
- What are the uses for valsartan/hydrochlorothiazide? (medicinenet.com)
- Valsartan/hydrochlorothiazide is used for the treatment of blood pressure in patients with or without a history of congestive heart failure . (medicinenet.com)
- What are the side effects of valsartan/hydrochlorothiazide? (medicinenet.com)
- Side effect of valsartan/hydrochlorothiazide are the same as its individual components. (medicinenet.com)
- The recommended starting dose of valsartan/hydrochlorothiazide is 80/12.5 to 160 mg/ 12.5 mg by mouth once daily. (medicinenet.com)
- Valsartan/hydrochlorothiazide can increase lithium ( Lithobid , Eskolith) levels in the body. (medicinenet.com)
- Is valsartan/hydrochlorothiazide safe to take if I'm pregnant or breastfeeding? (medicinenet.com)
- Valsartan/hydrochlorothiazide is not recommended for pregnant females. (medicinenet.com)
- Valsartan/hydrochlorothiazide is not recommended for females who are breastfeeding because it may enter breast milk . (medicinenet.com)
- What else should I know about valsartan/hydrochlorothiazide? (medicinenet.com)
- Valsartan/hydrochlorothiazide is available as tablets of 40, 80, 160 and 320 mg. (medicinenet.com)
- Valsartan/hydrochlorothiazide tablets should be stored between 15 C and 30 C (59 and 86 F). (medicinenet.com)
- valsartan/hydrochlorothiazide is available in generic form. (medicinenet.com)
- Valsartan and hydrochlorothiazide (Diovan HCT) is a combination of two prescription medicaiton used to treat high blood pressure. (medicinenet.com)
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- Mean blood pressures after dose adjustment were 131.6/73.3 mm Hg in the benazepril-amlodipine group and 132.5/74.4 mm Hg in the benazepril-hydrochlorothiazide group. (nih.gov)
Soluble in water3
- Hydrochlorothiazide is slightly soluble in water and freely soluble in sodium hydroxide solution. (rxlist.com)
- Hydrochlorothiazide is a white, or practically white, crystalline powder with a molecular weight of 297.74, which is slightly soluble in water, but freely soluble in sodium hydroxide solution. (rxlist.com)
- Hydrochlorothiazide is slightly soluble in water. (bioportfolio.com)
- Macleods Pharmaceuticals Limited is recalling one lot of Losartan Potassium/Hydrochlorothiazide combination tablets, a high blood pressure treatment. (consumeraffairs.com)
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- Accord Healthcare Inc. is voluntarily recalling One lot (Lot PW05264 - 46632 Bottles, NDC 16729-182-01) of Hydrochlorothiazide Tablets USP, 12.5 mg, to the consumer level. (fda.gov)
- A 100 count bottle of Hydrochlorothiazide Tablets USP 12.5 mg has been found to contain 100 Spironolactone Tablets USP 25 mg. (fda.gov)
- Accord's Hydrochlorothiazide Tablets USP 12.5 mg are light orange to peach colored, round, biconvex tablets debossed with H on one side and 1 on another side. (fda.gov)
High blood pr12
- Hydrochlorothiazide is used alone or in combination with other medications to treat high blood pressure. (medlineplus.gov)
- Hydrochlorothiazide controls high blood pressure but does not cure it. (medlineplus.gov)
- The combination of methyldopa and hydrochlorothiazide is used to treat high blood pressure. (medlineplus.gov)
- Hydrochlorothiazide is a diuretic (water pill) used for treating high blood pressure and accumulation of fluid. (medicinenet.com)
- Captopril/hydrochlorothiazide is used to treat high blood pressure. (healthline.com)
- For example, one of the ailments that hydrochlorothiazide is used to treat is high blood pressure . (wisegeek.com)
- In addition to high blood pressure, hydrochlorothiazide is also used to treat other medical conditions, one of them being fluid retention. (wisegeek.com)
- Bisoprolol/hydrochlorothiazide can control high blood pressure, but cannot cure it. (wholehealthmd.com)
- For the treatment of high blood pressure, the usual recommended adult dose of hydrochlorothiazide is 12.5 mg to 50 mg daily. (medbroadcast.com)
- Hydrochlorothiazide is used for treating high blood pressure. (lifestyletv.se)
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- Hydrochlorothiazide is a thiazide diuretic (water pill) that helps prevent your body from absorbing too much salt, which can cause fluid retention. (rexhealth.com)
- Captopril/hydrochlorothiazide is available as a generic drug. (healthline.com)
- Generic hydrochlorothiazide is available. (bingj.com)
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Called a thiazide diuretic1
- Hydrochlorothiazide is a type of medicine called a thiazide diuretic. (netdoctor.co.uk)
12.5 mg hydrochlorothiazide1
- It comes in these strengths: 150 mg aliskiren/12.5 mg hydrochlorothiazide, 150 mg aliskiren/25 mg hydrochlorothiazide, 300 mg aliskiren/12.5 mg hydrochlorothiazide, and 300 mg aliskiren/25 mg hydrochlorothiazide. (healthline.com)
Methyldopa and hydrochlorothiazide10
- To help you remember to take methyldopa and hydrochlorothiazide, take it around the same times every day. (medlineplus.gov)
- Do not stop taking methyldopa and hydrochlorothiazide without talking to your doctor. (medlineplus.gov)
- tell your doctor and pharmacist if you are allergic to methyldopa, hydrochlorothiazide, sulfa medications, any other medications, or any of the ingredients in methyldopa and hydrochlorothiazide tablets. (medlineplus.gov)
- If you become pregnant while taking methyldopa and hydrochlorothiazide, call your doctor. (medlineplus.gov)
- talk to your doctor about the risks and benefits of taking methyldopa and hydrochlorothiazide if you are 65 years of age or older. (medlineplus.gov)
- Older adults should not usually take methyldopa and hydrochlorothiazide because it is not as safe as other medications that can be used to treat the same condition. (medlineplus.gov)
- if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking methyldopa and hydrochlorothiazide. (medlineplus.gov)
- ask your doctor about the safe use of alcohol while you are taking methyldopa and hydrochlorothiazide. (medlineplus.gov)
- Alcohol can make the side effects from methyldopa and hydrochlorothiazide worse. (medlineplus.gov)
- ALDORIL (Methyldopa-Hydrochlorothiazide) combines two antihypertensives: methyldopa and hydrochlorothiazide. (rxlist.com)
- They all are identical unless in the instruction is indicated that it is a combination drug that contains Hydrochlorothiazide and other anti-hypertensive agent. (rxshop.md)
- Who should not take Moexipril-Hydrochlorothiazide? (webmd.com)
- There are no evaluations for Enalapril-Hydrochlorothiazide. (patientslikeme.com)
- Who should not take Olmesartan-Hydrochlorothiazide? (webmd.com)
- Hydrochlorothiazide is 6-chloro-3,4-dihydro-2 H -1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide. (rxlist.com)
Excretion of calcium2
- B. A. Lamberg and B. Kuhlback, "Effect of chlorothiazide and hydrochlorothiazide on the excretion of calcium in urine," Scandinavian Journal of Clinical and Laboratory Investigation , vol. 11, pp. 351-357, 1959. (hindawi.com)
- Hydrochlorothiazide also decreases the excretion of calcium and uric acid, may increase the excretion of iodide, and may reduce glomerular filtration rate. (bioportfolio.com)
- Lisinopril-hydrochlorothiazide (Zestoretic) 5/12.5 mg discount prices range from per pill or unit. (pharmacychecker.com)
- The combination of lisinopril with hydrochlorothiazide is used when blood pressure has not been lowered sufficiently using lisinopril on its own. (netdoctor.co.uk)
- Hydrochlorothiazide helps to lower blood pressure by eliminating unneeded water and salt from the body. (medlineplus.gov)
- Captopril/ hydrochlorothiazide can cause low blood pressure, especially during the first few days of starting treatment. (healthline.com)
- Hydrochlorothiazide does not usually affect normal blood pressure. (nih.gov)
- You may have very low blood pressure while taking hydrochlorothiazide and aliskiren. (rexhealth.com)
- If ALDORIL (methyldopa-hydrochlorothiazide) does not adequately control blood pressure , additional doses of other agents may be given. (rxlist.com)
- A 57-year-old black man, known to be hypertensive, had been treated the previous year with hydrochlorothiazide and methyldopa with satisfactory control of his blood pressure. (annals.org)
- people with normal blood pressure are not usually affected by hydrochlorothiazide. (bingj.com)
Allergic reaction to hydrochlorothiazide1
- Do not use this medicine if you had an allergic reaction to hydrochlorothiazide or a sulfa drug. (limamemorial.org)
- Hydrochlorothiazide crosses the placental but not the blood-brain barrier and is excreted in breast milk. (nih.gov)
- It is not known whether hydrochlorothiazide and aliskiren passes into breast milk or if it could harm a nursing baby. (rexhealth.com)
- Hydrochlorothiazide can pass into breast milk and may cause side effects in the nursing baby. (rexhealth.com)
- Hydrochlorothiazide can pass into breast milk and may harm a nursing baby. (cardiosmart.org)
- Hydrochlorothiazide passes into breast milk and could cause harm to a nursing baby. (cardiosmart.org)
- Not only can hydrochlorothiazide affect medical conditions, but it can also interfere with medications as well. (wisegeek.com)
- Talk to your doctor or pharmacist before taking any other medications at the same time as hydrochlorothiazide because some may not be suitable (including those bought over the counter). (bingj.com)
- What is the most important information I should know about hydrochlorothiazide and aliskiren? (rexhealth.com)
- What should I discuss with my healthcare provider before taking hydrochlorothiazide and aliskiren? (rexhealth.com)
- Hydrochlorothiazide and aliskiren can cause injury or death to the unborn baby if you take the medicine during your second or third trimester. (rexhealth.com)
- Hydrochlorothiazide and aliskiren is not approved for use by anyone younger than 18 years old. (rexhealth.com)
- If you need surgery or medical tests, tell the surgeon ahead of time that you are using hydrochlorothiazide and aliskiren. (rexhealth.com)
- Once the patient has been successfully titrated, ALDORIL (methyldopa-hydrochlorothiazide) may be substituted if the previously determined titrated doses are the same as in the combination. (rxlist.com)
- Those on the losartan-hydrochlorothiazide combination had an initial mean systolic reduction of 6 mm Hg, which increased to 14 mm Hg at week 8 and 16 mm Hg by the close of the treatment period. (thefreedictionary.com)
- The combination with hydrochlorothiazide, is known as hydrochlorothiazide/triamterene. (wikipedia.org)