Hyaluronoglucosaminidase: An enzyme that catalyzes the random hydrolysis of 1,4-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate. (From Enzyme Nomenclature, 1992) There has been use as ANTINEOPLASTIC AGENTS to limit NEOPLASM METASTASIS.Hyaluronic Acid: A natural high-viscosity mucopolysaccharide with alternating beta (1-3) glucuronide and beta (1-4) glucosaminidic bonds. It is found in the UMBILICAL CORD, in VITREOUS BODY and in SYNOVIAL FLUID. A high urinary level is found in PROGERIA.Chamomile: Common name for several daisy-like plants (MATRICARIA; TRIPLEUROSPERMUM; ANTHEMIS; CHAMAEMELUM) native to Europe and Western Asia, now naturalized in the United States and Australia.Glycosaminoglycans: Heteropolysaccharides which contain an N-acetylated hexosamine in a characteristic repeating disaccharide unit. The repeating structure of each disaccharide involves alternate 1,4- and 1,3-linkages consisting of either N-acetylglucosamine or N-acetylgalactosamine.Chondroitinases and Chondroitin Lyases: Enzymes which catalyze the elimination of glucuronate residues from chondroitin A,B, and C or which catalyze the hydrolysis of sulfate groups of the 2-acetamido-2-deoxy-D-galactose 6-sulfate units of chondroitin sulfate. EC 4.2.2.-.Chondroitin Sulfates: Derivatives of chondroitin which have a sulfate moiety esterified to the galactosamine moiety of chondroitin. Chondroitin sulfate A, or chondroitin 4-sulfate, and chondroitin sulfate C, or chondroitin 6-sulfate, have the sulfate esterified in the 4- and 6-positions, respectively. Chondroitin sulfate B (beta heparin; DERMATAN SULFATE) is a misnomer and this compound is not a true chondroitin sulfate.Glycocalyx: The carbohydrate-rich zone on the cell surface. This zone can be visualized by a variety of stains as well as by its affinity for lectins. Although most of the carbohydrate is attached to intrinsic plasma membrane molecules, the glycocalyx usually also contains both glycoproteins and proteoglycans that have been secreted into the extracellular space and then adsorbed onto the cell surface. (Alberts et al., Molecular Biology of the Cell, 3d ed, p502)Arachnida: A class of Arthropoda that includes SPIDERS; TICKS; MITES; and SCORPIONS.Sapotaceae: A plant family of the order Ebenales, subclass Dilleniidae, class Magnoliopsida that are tropical trees which have elongate latex cells. Several members bear sweet edible fruits and produce triterpenoid saponins.Drug Incompatibility: The quality of not being miscible with another given substance without a chemical change. One drug is not of suitable composition to be combined or mixed with another agent or substance. The incompatibility usually results in an undesirable reaction, including chemical alteration or destruction. (Dorland, 27th ed; Stedman, 25th ed)Lamiaceae: The mint plant family. They are characteristically aromatic, and many of them are cultivated for their oils. Most have square stems, opposite leaves, and two-lipped, open-mouthed, tubular corollas (united petals), with five-lobed, bell-like calyxes (united sepals).Spermatozoa: Mature male germ cells derived from SPERMATIDS. As spermatids move toward the lumen of the SEMINIFEROUS TUBULES, they undergo extensive structural changes including the loss of cytoplasm, condensation of CHROMATIN into the SPERM HEAD, formation of the ACROSOME cap, the SPERM MIDPIECE and the SPERM TAIL that provides motility.Bee Venoms: Venoms obtained from Apis mellifera (honey bee) and related species. They contain various enzymes, polypeptide toxins, and other substances, some of which are allergenic or immunogenic or both. These venoms were formerly used in rheumatism to stimulate the pituitary-adrenal system.Acrosome: The cap-like structure covering the anterior portion of SPERM HEAD. Acrosome, derived from LYSOSOMES, is a membrane-bound organelle that contains the required hydrolytic and proteolytic enzymes necessary for sperm penetration of the egg in FERTILIZATION.Chondroitin: A mucopolysaccharide constituent of chondrin. (Grant & Hackh's Chemical Dictionary, 5th ed)Jaagsiekte sheep retrovirus: A BETARETROVIRUS that causes pulmonary adenomatosis in sheep (PULMONARY ADENOMATOSIS, OVINE).Testis: The male gonad containing two functional parts: the SEMINIFEROUS TUBULES for the production and transport of male germ cells (SPERMATOGENESIS) and the interstitial compartment containing LEYDIG CELLS that produce ANDROGENS.Anesthesia, Local: A blocking of nerve conduction to a specific area by an injection of an anesthetic agent.Antigens, CD44: Acidic sulfated integral membrane glycoproteins expressed in several alternatively spliced and variable glycosylated forms on a wide variety of cell types including mature T-cells, B-cells, medullary thymocytes, granulocytes, macrophages, erythrocytes, and fibroblasts. CD44 antigens are the principle cell surface receptors for hyaluronate and this interaction mediates binding of lymphocytes to high endothelial venules. (From Abbas et al., Cellular and Molecular Immunology, 2d ed, p156)Cell Adhesion Molecules: Surface ligands, usually glycoproteins, that mediate cell-to-cell adhesion. Their functions include the assembly and interconnection of various vertebrate systems, as well as maintenance of tissue integration, wound healing, morphogenic movements, cellular migrations, and metastasis.Mucopolysaccharidoses: Group of lysosomal storage diseases each caused by an inherited deficiency of an enzyme involved in the degradation of glycosaminoglycans (mucopolysaccharides). The diseases are progressive and often display a wide spectrum of clinical severity within one enzyme deficiency.Sperm-Ovum Interactions: Interactive processes between the oocyte (OVUM) and the sperm (SPERMATOZOA) including sperm adhesion, ACROSOME REACTION, sperm penetration of the ZONA PELLUCIDA, and events leading to FERTILIZATION.Glucuronosyltransferase: A family of enzymes accepting a wide range of substrates, including phenols, alcohols, amines, and fatty acids. They function as drug-metabolizing enzymes that catalyze the conjugation of UDPglucuronic acid to a variety of endogenous and exogenous compounds. EC 188.8.131.52.Acrosin: A trypsin-like enzyme of spermatozoa which is not inhibited by alpha 1 antitrypsin.Lidocaine: A local anesthetic and cardiac depressant used as an antiarrhythmia agent. Its actions are more intense and its effects more prolonged than those of PROCAINE but its duration of action is shorter than that of BUPIVACAINE or PRILOCAINE.Cattle: Domesticated bovine animals of the genus Bos, usually kept on a farm or ranch and used for the production of meat or dairy products or for heavy labor.Chondroitin ABC Lyase: An enzyme that catalyzes the eliminative degradation of polysaccharides containing 1,4-beta-D-hexosaminyl and 1,3-beta-D-glucuronosyl or 1,3-alpha-L-iduronosyl linkages to disaccharides containing 4-deoxy-beta-D-gluc-4-enuronosyl groups. (Enzyme Nomenclature, 1992)Commiphora: A plant genus of the family BURSERACEAE which is a source of gugulipid and guggulu extract. Balm of Gilead is a common name more often referring to POPULUS and sometimes to ABIES.Streptococcus intermedius: A species of gram-positive bacteria in the STREPTOCOCCUS MILLERI GROUP. It is commonly found in the oropharynx flora and has a proclivity for abscess formation, most characteristically in the CENTRAL NERVOUS SYSTEM and LIVER.Anesthetics, Combined: The use of two or more chemicals simultaneously or sequentially to induce anesthesia. The drugs need not be in the same dosage form.Uronic Acids: Acids derived from monosaccharides by the oxidation of the terminal (-CH2OH) group farthest removed from the carbonyl group to a (-COOH) group. (From Stedmans, 26th ed)Lactobacillales: An order of gram-positive bacteria in the class Bacilli, that have the ability to ferment sugars to lactic acid. They are widespread in nature and commonly used to produce fermented foods.Chondroitinsulfatases: A group of enzymes that catalyze the hydrolysis of various sulfate bonds of chondroitin sulfate. EC 3.1.6.-.Clethraceae: A plant family of the order Ericales, subclass Dilleniidae, class Magnoliopsida.Clitoria: A plant genus of the family FABACEAE that contains ternatins (anthocyanins) and preternatins, antifungal proteins, stigmast-4-ene-3,6-dione, and clitoriacetal (ROTENONE).Hydrolyzable Tannins: Polymeric derivatives of GALLIC ACID that are esters of a sugar.Dermatan Sulfate: A naturally occurring glycosaminoglycan found mostly in the skin and in connective tissue. It differs from CHONDROITIN SULFATE A (see CHONDROITIN SULFATES) by containing IDURONIC ACID in place of glucuronic acid, its epimer, at carbon atom 5. (from Merck, 12th ed)Cataract Extraction: The removal of a cataractous CRYSTALLINE LENS from the eye.Wasp Venoms: Venoms produced by the wasp (Vespid) family of stinging insects, including hornets; the venoms contain enzymes, biogenic amines, histamine releasing factors, kinins, toxic polypeptides, etc., and are similar to bee venoms.Oils, Volatile: Oils which evaporate readily. The volatile oils occur in aromatic plants, to which they give odor and other characteristics. Most volatile oils consist of a mixture of two or more TERPENES or of a mixture of an eleoptene (the more volatile constituent of a volatile oil) with a stearopten (the more solid constituent). The synonym essential oils refers to the essence of a plant, as its perfume or scent, and not to its indispensability.Chondroitin Lyases: Enzymes which catalyze the elimination of delta-4,5-D-glucuronate residues from polysaccharides containing 1,4-beta-hexosaminyl and 1,3-beta-D-glucuronosyl or 1,3-alpha-L-iduronosyl linkages thereby bringing about depolymerization. EC 184.108.40.206 acts on chondroitin sulfate A and C as well as on dermatan sulfate and slowly on hyaluronate. EC 220.127.116.11 acts on chondroitin sulfate A and C.Hydrogen-Ion Concentration: The normality of a solution with respect to HYDROGEN ions; H+. It is related to acidity measurements in most cases by pH = log 1/2[1/(H+)], where (H+) is the hydrogen ion concentration in gram equivalents per liter of solution. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)Polysaccharide-Lyases: A group of carbon-oxygen lyases. These enzymes catalyze the breakage of a carbon-oxygen bond in polysaccharides leading to an unsaturated product and the elimination of an alcohol. EC 4.2.2.Phimosis: A condition in which the FORESKIN cannot be retracted to reveal the GLANS PENIS. It is due to tightness or narrowing of the foreskin opening.Sperm Capacitation: The structural and functional changes by which SPERMATOZOA become capable of oocyte FERTILIZATION. It normally requires exposing the sperm to the female genital tract for a period of time to bring about increased SPERM MOTILITY and the ACROSOME REACTION before fertilization in the FALLOPIAN TUBES can take place.Larva Migrans: Infections caused by nematode larvae which never develop into the adult stage and migrate through various body tissues. They commonly infect the skin, eyes, and viscera in man. Ancylostoma brasiliensis causes cutaneous larva migrans. Toxocara causes visceral larva migrans.Wasps: Any of numerous winged hymenopterous insects of social as well as solitary habits and having formidable stings.Hemorrhagic Septicemia: Any of several bacterial diseases, usually caused by PASTEURELLA MULTOCIDA, marked by the presence of hemorrhagic areas in the subcutaneous tissues, serous membranes, muscles, lymph glands, and throughout the internal organs. The diseases primarily affect animals and rarely humans.Acetylglucosaminidase: A beta-N-Acetylhexosaminidase that catalyzes the hydrolysis of terminal, non-reducing 2-acetamido-2-deoxy-beta-glucose residues in chitobiose and higher analogs as well as in glycoproteins. Has been used widely in structural studies on bacterial cell walls and in the study of diseases such as MUCOLIPIDOSIS and various inflammatory disorders of muscle and connective tissue.Bupivacaine: A widely used local anesthetic agent.Insulin, Short-Acting: Insulin derivatives and preparations that are designed to induce a rapid HYPOGLYCEMIC EFFECT.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Microbial Collagenase: A metalloproteinase which degrades helical regions of native collagen to small fragments. Preferred cleavage is -Gly in the sequence -Pro-Xaa-Gly-Pro-. Six forms (or 2 classes) have been isolated from Clostridium histolyticum that are immunologically cross-reactive but possess different sequences and different specificities. Other variants have been isolated from Bacillus cereus, Empedobacter collagenolyticum, Pseudomonas marinoglutinosa, and species of Vibrio and Streptomyces. EC 18.104.22.168.Anesthetics, Local: Drugs that block nerve conduction when applied locally to nerve tissue in appropriate concentrations. They act on any part of the nervous system and on every type of nerve fiber. In contact with a nerve trunk, these anesthetics can cause both sensory and motor paralysis in the innervated area. Their action is completely reversible. (From Gilman AG, et. al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed) Nearly all local anesthetics act by reducing the tendency of voltage-dependent sodium channels to activate.Simuliidae: Several species of the genus Simulium (family Simuliidae) that act as intermediate hosts (vectors) for the parasitic disease ONCHOCERCIASIS.Streptococcus pyogenes: A species of gram-positive, coccoid bacteria isolated from skin lesions, blood, inflammatory exudates, and the upper respiratory tract of humans. It is a group A hemolytic Streptococcus that can cause SCARLET FEVER and RHEUMATIC FEVER.GPI-Linked Proteins: A subclass of lipid-linked proteins that contain a GLYCOSYLPHOSPHATIDYLINOSITOL LINKAGE which holds them to the CELL MEMBRANE.Lubrication: The application of LUBRICANTS to diminish FRICTION between two surfaces.Cartilage: A non-vascular form of connective tissue composed of CHONDROCYTES embedded in a matrix that includes CHONDROITIN SULFATE and various types of FIBRILLAR COLLAGEN. There are three major types: HYALINE CARTILAGE; FIBROCARTILAGE; and ELASTIC CARTILAGE.Eyelids: Each of the upper and lower folds of SKIN which cover the EYE when closed.Zona Pellucida: A tough transparent membrane surrounding the OVUM. It is penetrated by the sperm during FERTILIZATION.Terminalia: A plant genus of the family COMBRETACEAE. Members contain arjunin, an ellagitannin (TANNINS).Ancylostoma: A genus of nematode intestinal parasites that consists of several species. A. duodenale is the common hookworm in humans. A. braziliense, A. ceylonicum, and A. caninum occur primarily in cats and dogs, but all have been known to occur in humans.Extracellular Matrix: A meshwork-like substance found within the extracellular space and in association with the basement membrane of the cell surface. It promotes cellular proliferation and provides a supporting structure to which cells or cell lysates in culture dishes adhere.Betamethasone Valerate: The 17-valerate derivative of BETAMETHASONE. It has substantial topical anti-inflammatory activity and relatively low systemic anti-inflammatory activity.Vitreous Body: The transparent, semigelatinous substance that fills the cavity behind the CRYSTALLINE LENS of the EYE and in front of the RETINA. It is contained in a thin hyaloid membrane and forms about four fifths of the optic globe.Ceratopogonidae: A family of biting midges, in the order DIPTERA. It includes the genus Culicoides which transmits filarial parasites pathogenic to man and other primates.Oligosaccharides: Carbohydrates consisting of between two (DISACCHARIDES) and ten MONOSACCHARIDES connected by either an alpha- or beta-glycosidic link. They are found throughout nature in both the free and bound form.Adjuvants, Pharmaceutic: Agents that aid or increase the action of the principle drug (DRUG SYNERGISM) or that affect the absorption, mechanism of action, metabolism, or excretion of the primary drug (PHARMACOKINETICS) in such a way as to enhance its effects.Rabbits: The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.Pronase: A proteolytic enzyme obtained from Streptomyces griseus.beta-N-Acetylhexosaminidases: A hexosaminidase specific for non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides. It acts on GLUCOSIDES; GALACTOSIDES; and several OLIGOSACCHARIDES. Two specific mammalian isoenzymes of beta-N-acetylhexoaminidase are referred to as HEXOSAMINIDASE A and HEXOSAMINIDASE B. Deficiency of the type A isoenzyme causes TAY-SACHS DISEASE, while deficiency of both A and B isozymes causes SANDHOFF DISEASE. The enzyme has also been used as a tumor marker to distinguish between malignant and benign disease.GlucuronidaseCumulus Cells: The granulosa cells of the cumulus oophorus which surround the OVUM in the GRAAFIAN FOLLICLE. At OVULATION they are extruded with OVUM.Chromatography: Techniques used to separate mixtures of substances based on differences in the relative affinities of the substances for mobile and stationary phases. A mobile phase (fluid or gas) passes through a column containing a stationary phase of porous solid or liquid coated on a solid support. Usage is both analytical for small amounts and preparative for bulk amounts.Molecular Weight: The sum of the weight of all the atoms in a molecule.Depsides: Phenolic benzoic acid esters.Streptococcus: A genus of gram-positive, coccoid bacteria whose organisms occur in pairs or chains. No endospores are produced. Many species exist as commensals or parasites on man or animals with some being highly pathogenic. A few species are saprophytes and occur in the natural environment.Histological Techniques: Methods of preparing tissue for examination and study of the origin, structure, function, or pathology.Proteoglycans: Glycoproteins which have a very high polysaccharide content.Phlebotomus: A genus of PSYCHODIDAE which functions as the vector of a number of pathogenic organisms, including LEISHMANIA DONOVANI; LEISHMANIA TROPICA; Bartonella bacilliformis, and the Pappataci fever virus (SANDFLY FEVER NAPLES VIRUS).Injections: Introduction of substances into the body using a needle and syringe.
... and hyaluronidase. PSGAG inhibits the synthesis of prostaglandin E2, which is released upon joint injury and causes ...
... is a class of prescription drugs in India appearing as an appendix to the Drugs and Cosmetics Rules, 1945 introduced in 1945. These are drugs which cannot be purchased over the counter without the prescription of a qualified doctor.The manufacture and sale of all drugs are covered under the Drugs and Cosmetics Act and Rules. It is revised at times based on the advice of the Drugs Technical Advisory Board, part of the Central Drugs Standard Control Organization in the Ministry of Health and Family Welfare. The most recent schedule H (2006) lists 536 drugs from abacavir to zuclopenthixol. However, enforcement of Schedule H laws in India is lax, compared to the more restrictive Schedule X, for which a mandatory documentation trail must be maintained. ...
Other names in common use include hyaluronidase [but cf. internal_xref(ec_num(3,2,1,35)), (hyalurononglucosaminidase) and ... Meyer K, Rapport MM (1952). "Hyaluronidases". Advances in Enzymology and Related Subjects of Biochemistry. 13: 199-236. PMID ...
Meyer, K.; Hoffman, P.; Linker, A. (1960). "Hyaluronidases". In Boyer, P.D.; Lardy, H.; Myrbaumlck, K. The Enzymes. 4 (2nd ed ... Hyaluronoglucuronidase (EC 22.214.171.124, hyaluronidase, glucuronoglucosaminoglycan hyaluronate lyase, orgelase) is an enzyme with ... "The production of hyaluronate oligosaccharides by leech hyaluronidase and alkali". J. Biol. Chem. 235: 924-927. PMID 14417285. ...
Examples are hyaluronidase and collagenase. These molecules, however, are enzymes that are secreted by a variety of organisms ...
R Stern; S Shuster; TS Wiley; B Formby (2001). "Hyaluronidase can modulate expression of CD44". Exp Cell Res. 266 (1): 167-76. ...
The disorder results from hyaluronidase deficiency. Symptoms included nodular soft-tissue masses located around joints, with ...
Hyaluronidase-1 is an enzyme that in humans is encoded by the HYAL1 gene. This gene encodes a lysosomal hyaluronidase. ... 1998). "The hyaluronidase gene HYAL1 maps to chromosome 3p21.2-p21.3 in human and 9F1-F2 in mouse, a conserved candidate tumor ... This enzyme is active at an acidic pH and is the major hyaluronidase in plasma. Mutations in this gene are associated with ... 2002). "Regulation of hyaluronidase activity by alternative mRNA splicing". J. Biol. Chem. 277 (37): 33654-63. doi:10.1074/jbc. ...
Hyaluronidase can improve absorption via hypodermoclysis. Evan O'Neill Kane "hypodermoclysis", Merriam-Webster's medical ...
... can be degraded by a family of enzymes called hyaluronidases. In humans, there are at least seven types of ... Hypoxia also increases production of HA and activity of hyaluronidases. The hyaluronic acid receptors, CD44 and RHAMM, are most ... Morriss-Kay GM, Tuckett F, Solursh M (1986). "The effects of Streptomyces hyaluronidase on tissue organization and cell cycle ... HA fragments promote angiogenesis and hyaluronidases produce these fragments. ...
"Hyaluronidases in cancer biology." Seminars in cancer biology. Vol. 18. No. 4. Academic Press, 2008. Sattler, Ulrike GA, and ...
Hyaluronan synthase Hyaluronidase Toole, B.P. (October 1990). "Hyaluronan and its binding proteins, the hyaladherins". Current ...
Comtesse N, Maldener E, Meese E (2001). "Identification of a nuclear variant of MGEA5, a cytoplasmic hyaluronidase and a beta-N ... "Entrez Gene: MGEA5 meningioma expressed antigen 5 (hyaluronidase)". Nakajima D, Okazaki N, Yamakawa H, et al. (2003). " ... "Novel immunogenic antigen homologous to hyaluronidase in meningioma". Hum Mol Genet. 7 (12): 1859-72. doi:10.1093/hmg/7.12.1859 ...
"Inhibitory activity of brown algal phlorotannins against hyaluronidase". International Journal of Food Science and Technology. ...
This gene encodes a protein which is similar in structure to hyaluronidases. Hyaluronidases intracellularly degrade hyaluronan ... However, this protein has not yet been shown to have hyaluronidase activity. The gene is one of several related genes in a ... 2002). "Regulation of hyaluronidase activity by alternative mRNA splicing". J. Biol. Chem. 277 (37): 33654-63. doi:10.1074/jbc. ... Hyaluronidase-3 is an enzyme that in humans is encoded by the HYAL3 gene. ...
Hyaluronidase PH-20 is an enzyme that in humans is encoded by the SPAM1 gene. Hyaluronidase degrades hyaluronic acid, a major ... 1994). "A hyaluronidase activity of the sperm plasma membrane protein PH-20 enables sperm to penetrate the cumulus cell layer ... Csoka AB, Frost GI, Stern R (2002). "The six hyaluronidase-like genes in the human and mouse genomes". Matrix Biol. 20 (8): 499 ... Six members of the hyaluronidase family are clustered into two tightly linked groups on chromosome 3p21.3 and 7q31.3. This gene ...
Hylenex is a hyaluronidase (human recombinant) injection indicated for use in subcutaneous fluid administration, dispersion and ... Enhanze: Uses recombinant human hyaluronidase to degrade HA and aids in the absorption and dispersion of co-administered ... Halozyme has one FDA approved product (Hylenex recombinant, hyaluronidase human injection). The company also licenses its drug ... A Study of PEGylated Recombinant Human Hyaluronidase in Combination With Nab-Paclitaxel Plus Gemcitabine Compared With Placebo ...
The first stage is the penetration of corona radiata, by releasing hyaluronidase from the acrosome to digest cumulus cells ... In mammals the acrosome reaction releases hyaluronidase and acrosin; their role in fertilization is not yet clear. The ...
Within infected tissues, this yeast produces several enzymes such as proteinase, phospholipase, hyaluronidase and chondroitin- ... Coutinho, S.D.; Paula, C.R. (2000). "Proteinase, phospholipase, hyaluronidase and chondroitin-sulphatase production by ...
In 1966, Cameron published his first book, Hyaluronidase and Cancer. In 1971, Cameron began corresponding with Dr. Linus ...
The role of hyaluronidase in the disease process is controversial. The presence of a heat-labile capsule has been reported as ... The presence of a hyaluronidase and neuraminidase has been recognized, and neuraminidase was shown to play a significant role ...
Sometimes hyaluronidase (an enzyme) is also injected to dissolve the adhesions.) It was developed at Texas Tech University ...
Kovar JL, Johnson MA, Volcheck WM, Chen J, Simpson MA (October 2006). "Hyaluronidase expression induces prostate tumor ...
Suzuki K, Terasaki Y, Uyeda M (2002). "Inhibition of hyaluronidases and chondroitinases by fatty acids". J. Enzyme. Inhib. Med ...
This filler can be dissolved with injections of an enzyme called hyaluronidase. Liquid silicone - Medical grade silicone is ...
Hyaluronidase is a recommended antidote for vinca alkaloid overdose or extravasation. The role of hyaluronidases in cancer has ... Hyaluronidase is also used for extravasation of hyperosmolar solutions. Brand names of animal-derived hyaluronidase include ... Isoyama, T. (13 July 2005). "Differential selectivity of hyaluronidase inhibitors toward acidic and basic hyaluronidases". ... having a function akin to bacterial hyaluronidases. In most mammalian fertilization, hyaluronidase is released by the acrosome ...
Hyaluronidase deficiency (also known as "mucopolysaccharidosis type IX") is a condition caused by mutations in HYAL1, and ...
Daratumumab and Hyaluronidase-fihj Injection: learn about side effects, dosage, special precautions, and more on MedlinePlus ... Hyaluronidase-fihj is an endoglycosidase. It helps to keep daratumumab in the body longer so that the medication will have a ... Daratumumab and hyaluronidase-fihj injection may cause side effects. Tell your doctor if any of these symptoms are severe or do ... Daratumumab and hyaluronidase-fihj injection is used with other medications to treat multiple myeloma (a type of cancer of the ...
Rituximab and Hyaluronidase Human Injection: learn about side effects, dosage, special precautions, and more on MedlinePlus ... Rituximab and hyaluronidase human injection may cause side effects. Tell your doctor if any of these symptoms are severe or do ... Rituximab and hyaluronidase human injection is used alone or with other medications to treat various types of non-Hodgkins ... Rituximab and hyaluronidase human injection comes as a solution (liquid) to be injected subcutaneously (under the skin, in the ...
Easy-to-read patient leaflet for Hyaluronidase Injection (Human). Includes indications, proper use, special instructions, ... Hyaluronidase Injection (Human). Generic Name: Hyaluronidase Injection (Human) (hye al yoor ON i dase). Brand Name: Hylenex ... Hypodermoclysis hyaluronidase, Hylenex, Amphadase, Vitrase, More.... Subcutaneous Urography hyaluronidase, Hylenex, Amphadase, ... What do I need to tell my doctor BEFORE I take Hyaluronidase Injection?. *If you have an allergy to hyaluronidase or any other ...
Professional guide for Hyaluronidase. Includes: pharmacology, pharmacokinetics, contraindications, interactions, adverse ... Larger doses of hyaluronidase may be required. Consider therapy modification. Local Anesthetics: Hyaluronidase may enhance the ... DOPamine: Hyaluronidase may enhance the adverse/toxic effect of DOPamine. Management: Avoid the use of hyaluronidase to enhance ... Management: Avoid the use of hyaluronidase to enhance dispersion or absorption of alpha-/beta-agonists. Use of hyaluronidase ...
Media related to Hyaluronidase at Wikimedia Commons. *Hyaluronidase at the US National Library of Medicine Medical Subject ... "Hyaluronidase". ENZYME. ExPASy. Retrieved 17 November 2016.. *^ "Halozyme Therapeutics and Baxter Healthcare Corporation ... "Differential selectivity of hyaluronidase inhibitors toward acidic and basic hyaluronidases". Glycobiology. 16 (1): 11-21. doi: ... Meyer, K (1971). "Hyaluronidases". In Boyer PD (ed.). Enzymes. V. New York: Academic Press. pp. 307-320. ISBN 978-0-12-122705-0 ...
... Harmony Tyner1 and Robin Patel1,2 ... S. Tolksdorf and M. H. McCready, "The turbidimetric assay of hyaluronidase," The Journal of Laboratory and Clinical Medicine, ... W. L. Hynes and S. L. Walton, "Hyaluronidases of Gram-positive bacteria," FEMS Microbiology Letters, vol. 183, no. 2, pp. 201- ... R. F. Smith and N. P. Willett, "Rapid plate method for screening hyaluronidase and chondroitin sulfatase-producing ...
Everything you need to know about Hyaluronidase in a short, helpful guide. Learn about where it can be found, its benefits, and ... What is Hyaluronidase?. Hyaluronidase performs a crucial role in allowing the effects of hyaluronic acid (which is mainly found ... What other functions does Hyaluronidase offer?. Hyaluronidase has proved beneficial in various biotechnological processes. As ... Hyaluronidase is one of a wide number of complex proteins called enzymes which to help to speed up and regulate a number of ...
What is rituximab/hyaluronidase?. A new subcutaneous formulation of rituximab, combined with human hyaluronidase to help ... Rituximab/Hyaluronidase (Rituxan Hycela™). Melaragno, Adam PharmD, BCOP. Oncology Times: October 25, 2017 - Volume 39 - Issue ... Rituximab/hyaluronidase should only be administered after a patient has received and tolerated at least one full dose of IV ... How does rituximab/hyaluronidase work?. Rituximab is a monoclonal antibody targeting CD20. Upon binding to the receptor, cell ...
Hyaluronidase and trastuzumab is a combination medicine used to treat certain types of breast cancer. Hyaluronidase and ... Hyaluronidase is a genetically designed protein. Trastuzumab is a cancer medicine. ... What is hyaluronidase and trastuzumab?. Hyaluronidase is a genetically designed protein. Trastuzumab is a cancer medicine. ... What other drugs will affect hyaluronidase and trastuzumab?. Other drugs may affect hyaluronidase and trastuzumab, including ...
Pertuzumab, Trastuzumab, and Hyaluronidase - Last updated on August 5, 2020. ©2020 Memorial Sloan Kettering Cancer Center. ...
Hyaluronidase Injection) may treat, uses, dosage, side effects, drug interactions, warnings, patient labeling, reviews, and ... Amphadase® (hyaluronidase injection) is supplied sterile as 150 USP units of hyaluronidase per mL in a 2 mL single-use glass ... Hyaluronidase should not be applied directly to the cornea.. Enzyme Inactivation With Intravenous Administration. Hyaluronidase ... hyaluronidase) injection. DESCRIPTION. Amphadase® is a preparation of purified bovine testicular hyaluronidase, a protein ...
Hyaluronidase is a genetically designed protein used as an aid in helping your body absorb other injected medications. Immune ... What is hyaluronidase and immune globulin?. Hyaluronidase is a genetically designed protein used as an aid in helping your body ... How is hyaluronidase and immune globulin given?. Hyaluronidase and immune globulin is usually given once every 4 weeks. Follow ... Hyaluronidase and immune globulin comes in a kit that contains a "dual vial" unit. The small vial contains hyaluronidase and ...
Hyaluronidase is an enzyme that catalyzes breakdown of HA. Approved label use of hyaluronidase includes treatment of ... L. E. Clark and J. R. Mellette Jr., "The use of hyaluronidase as an adjunct to surgical procedures," The Journal of ... Of late, hyaluronidase is tested for management of secondary complications associated with plastic surgery  and as an ... Hyaluronidase is an enzyme that catalyzes breakdown of hyaluronic acid. This property is utilized for hypodermoclysis and for ...
Rituximab and Hyaluronidase Human Injection (Rituxan Hycela™) is a form of the medication rituximab, used to treat several ... About: Rituximab and Hyaluronidase Human Injection (Rituxan Hycela™) Rituximab and hyaluronidase human injection is a synthetic ... How to Take Rituximab and Hyaluronidase Human Injection. Rituximab and hyaluronidase human injection is given by subcutaneous ... Hyaluronidase is an enzyme that is used in this medication to increase the absorption of rituximab when it is given ...
Hyaluronidase catalyzes the hydrolysis of hyaluronic acid (HA), an anionic, nonsulfated glycosaminoglycan distributed widely ... Hyaluronidase conohyal-P1Sequence analysisAdd BLAST. 440. Amino acid modifications. Feature key. Position(s). Description ... Hyaluronidase conohyal-P11 Publication. ,p>Manually curated information that is based on statements in scientific articles for ... "Isolation and characterization of Conohyal-P1, a hyaluronidase from the injected venom of Conus purpurascens.". Moeller C., ...
References for Abcams Anti-Hyaluronidase PH20 antibody (ab22199). Please let us know if you have used this product in your ...
Hyal3 hyaluronidase 3 [Rattus norvegicus] Hyal3 hyaluronidase 3 [Rattus norvegicus]. Gene ID:300993 ... hyaluronidase 3provided by RGD. Primary source. RGD:1303334 See related. Ensembl:ENSRNOG00000016093 Gene type. protein coding. ... hyaluronidase-3. Names. hyal-3. hyaluronoglucosaminidase 3. NP_997482.2. *EC 126.96.36.199 ... Regulation of hyaluronidase activity by alternative mRNA splicing. Lokeshwar VB, et al. J Biol Chem, 2002 Sep 13. PMID 12084718 ...
Hyaluronidase-4. Hyaluronidase-4, Hyal-4, EC 188.8.131.52 (Chondroitin sulfate endo-beta-N-acetylgalactosaminidase) (Chondroitin ... Hyaluronidase-4Imported. ,p>Information which has been imported from another database using automatic procedures.,/p> ,p>,a ... tr,C9J6F9,C9J6F9_HUMAN Hyaluronidase-4 (Fragment) OS=Homo sapiens OX=9606 GN=HYAL4 PE=4 SV=1 ...
Hyaluronidase Failure Trips Partners; Halozyme Plummets By Marie Powers Staff Writer Wednesday, August 8, 2012 ... took a double hit Thursday as FDA concerns about its recombinant human hyaluronidase (rHuPH20) enzyme sidetracked programs at ...
Hyaluronidase and rituximab is a combination medicine used to treat follicular lymphoma, diffuse large B-cell lymphoma, or ... Hyaluronidase is a genetically designed protein. Rituximab is a cancer medicine that interferes with the growth and spread of ... What is hyaluronidase and rituximab?. Hyaluronidase is a genetically designed protein.. Rituximab is a cancer medicine that ... How is hyaluronidase and rituximab given?. Before you receive a hyaluronidase and rituximab injection, you will receive an ...
Hyaluronidase for Hyaluronic Acid Hydrolysis > Hyaluronidase (Hyaluronate Lyase) ...
Of these, Group A had 4 ml lignocaine 2%, while Group B had 4 ml lignocaine 2% with the addition of sodium hyaluronidase 75 IU/ ... The addition of hyaluronidase in sub-Tenons anaesthesia has a significant effect in improving ocular and lid (levator and ... To assess the effect of hyaluronidase on eye and eyelid movements when used as an adjunct in sub-Tenons anaesthesia. A total ... Table 4 Results of previous studies of STB with hyaluronidase (H*). Full size table. ...
The high-dose pulsed hyaluronidase treatments works based on the concept that a sufficient amount of hyaluronidase with a high ... The amount of hyaluronidase varies on the location of the condition, but it is typically suggested to use 500 U for 1 vascular ... It was decided to dissolve the HA filler material using 1,000 units (U) of high-dose pulsed hyaluronidase due to the cheek and ... When it comes to treating the condition with hyaluronidase, it is important to know the entire area that is involved with the ...
RecombinantSubcutaneousRituximab and hyaluronidase humanBovineEffect of hyaluronidaseAddition of hyaluronidaseInjectionsEnzymesProteinHycelaHYAL2Amphadase1500ExtracellularSubcutaneouslyHumanVialDegrades hyaluronanAllergicUnits of hyaluronidaseAmount of hyaluronidaseEffects of hyaluronidaseHyaluronan1.35StreptococcusInjectAntibodyAnti-hyaluronidaseEnzyme hyaluronidaseGeneTreat primary immunodeficiencyHYAL1FillerIntravenousCharacterizationDoseDegradationOcular akinesiaInhibitionTrastuzumabEnzymatic AssayLidocaineBreakdown of hyaluronicVenomInhibitory effectExtravasation injuryPreparationsInjection is a spreadingActivityOphthalmologyMedicationCleavesInhibitorsEndoglycosidaseDispersion and absorptionImmuneTumor
- On December 2, 2005, the FDA approved a synthetic (recombinant or rDNA) "human" hyaluronidase, Hylenex (Halozyme Therapeutics). (wikipedia.org)
- Halozyme Therapeutics Inc. took a double hit Thursday as FDA concerns about its recombinant human hyaluronidase (rHuPH20) enzyme sidetracked programs at two partners and sent the stock into a tailspin. (bioworld.com)
- OBJECTIVE To compare the pharmacokinetics and glucodynamics of three rapid-acting insulin analogs (aspart, glulisine, and lispro) injected subcutaneously with or without recombinant human hyaluronidase (rHuPH20). (diabetesjournals.org)
- The purpose of this study is to compare the efficacy and safety of PEGylated Recombinant Human Hyaluronidase (PEGPH20) combined with nab-paclitaxel plus gemcitabine (PAG treatment), compared with placebo combined with nab-paclitaxel plus gemcitabine (AG treatment), in participants with hyaluronan (HA)-high Stage IV previously untreated pancreatic ductal adenocarcinoma (PDA). (clinicaltrials.gov)
- The purpose of the study is to determine the feasibility of infusing a full 4-week dose of Immune Globulin Intravenous (Human), 10% in a single subcutaneous site and the amount of recombinant human hyaluronidase needed to infuse that dose with no more than mild local adverse drug reactions. (clinicaltrials.gov)
- Ability to administer, after priming with recombinant human hyaluronidase, at least one half of a 4-week dose (minimum of 200 mg/kg) of IgG in a single infusion site, via the subcutaneous route, with no more than mild local adverse drug reactions. (clinicaltrials.gov)
- The expression of recombinant hyaluronidase from Apis mellifera in E. coli BL21(DE3) was analyzed using a face centered design of experiment approach. (mdpi.com)
- Active recombinant hyaluronidase IBs can be immediately used for direct degradation of hyaluronan without further down streaming steps. (mdpi.com)
- Participants will receive 1200 mg ( daratumumab 1200 milligram (mg) with Recombinant Human Hyaluronidase [ rHuPH20 ] 30,000 U) via mixing immediately before Subcutaneous (SC) infusion once weekly in Cycles 1 (each cycle is 28 days) and 2, every 2 weeks in Cycles 3-6, and then every 4 weeks in subsequent cycles until disease progression. (clinicaltrials.gov)
- As recombinant human hyaluronidases are now available the bovine preparations can be replaced by the human enzymes. (springer.com)
- Detection of the pH-dependent activity of PH-20 type hyaluronidases, i.e. recombinant human PH-20 (rhPH-20) and BTH, showed a shift of the pH optimum from acidic pH values in a colorimetric activity assay to higher pH values in a turbidimetric activity assay. (springer.com)
- Contrarily, recombinant human Hyal-1 (rhHyal-1) and bee venom hyaluronidase (BVH) exhibited nearly identical pH profiles in both commonly used types of activity assays. (springer.com)
- Thrombosis may occur with immune globulin/recombinant human hyaluronidase in patients with or without known risk factors. (adam.com)
- Immune globulin and recombinant human hyaluronidase injection is used to treat primary immunodeficiency (PI) in adults. (adam.com)
- Appropriate studies have not been performed on the relationship of age to the effects of immune globulin and recombinant human hyaluronidase injection in the pediatric population. (adam.com)
- However, elderly patients are more likely to have age-related blood clotting problems, kidney or heart problems, which may require caution for patients receiving immune globulin and recombinant human hyaluronidase injection. (adam.com)
- Cloning and nucleotide sequence of the Streptococcus pneumoniae hyaluronidase gene and purification of the enzyme from recombinant Escherichia coli. (asm.org)
- This clone contained a recombinant cosmid (designated pJCP800) with an approximately 35-kb DNA insert, and the putative hyaluronidase coding sequence was subcloned into pBluescript SK as a 3.8-kb PstI-ClaI fragment (designated pJCP802). (asm.org)
- Halozyme has granted ViroPharma an exclusive worldwide license to use Halozyme's proprietary Enhanze technology, a proprietary drug delivery platform using Halozyme's recombinant human hyaluronidase enzyme (rHuPH20) technology in combination with a C1 esterase inhibitor. (thefreedictionary.com)
- Herceptin Hylecta is a fixed dose combination of trastuzumab, a HER2/neu receptor antagonist, with Halozyme's proprietary recombinant human hyaluronidase enzyme (Enhanze technology), which has been shown to increase the absorption rate of a trastuzumab. (centerwatch.com)
- A new subcutaneous formulation of rituximab, combined with human hyaluronidase to help increase dispersion and absorption of rituximab after subcutaneous administration. (lww.com)
- Hyaluronidase is included to increase the permeability of the subcutaneous tissue by depolymerizing hyaluronan at the site of injection. (lww.com)
- Rituximab and hyaluronidase human injection is given by subcutaneous injection (a needle inserted under the skin in the stomach (abdomen) area). (oncolink.org)
- OTCQX: RHHBY) announced today that the US Food and Drug Administration (FDA) approved Rituxan Hycela™ (rituximab and hyaluronidase human) for subcutaneous (under the skin) injection, for the treatment of adults with the following blood cancers: previously untreated and relapsed or refractory follicular lymphoma, previously untreated diffuse large B-cell lymphoma (DLBCL), and previously untreated and previously treated chronic lymphocytic leukaemia (CLL). (roche.com)
- Rituximab and hyaluronidase human injection has caused severe, life-threatening skin and mouth reactions. (medlineplus.gov)
- In this case, receiving rituximab and hyaluronidase human injection may increase the risk that your infection will become more serious or life-threatening and you will develop symptoms. (medlineplus.gov)
- If necessary, your doctor may give you medication to treat this infection before and during your treatment with rituximab and hyaluronidase human injection. (medlineplus.gov)
- Your doctor will order certain lab tests to check your body's response to rituximab and hyaluronidase human injection. (medlineplus.gov)
- Talk to your doctor about the risks of using rituximab and hyaluronidase human injection. (medlineplus.gov)
- Rituximab and hyaluronidase human injection is in a class of medications called monoclonal antibodies. (medlineplus.gov)
- Rituximab and hyaluronidase human injection comes as a solution (liquid) to be injected subcutaneously (under the skin, in the stomach area) over approximately 5 to 7 minutes. (medlineplus.gov)
- Rituximab and hyaluronidase human injection may cause serious reactions while you receive the medication or within 24 hours after receiving a dose. (medlineplus.gov)
- You will receive each dose of rituximab and hyaluronidase human injection in a medical facility, and a doctor or nurse will monitor you carefully while you are receiving the medication and for at least 15 minutes after you receive the medication. (medlineplus.gov)
- You will receive certain medications to help prevent an allergic reaction before you receive each dose of rituximab and hyaluronidase human injection. (medlineplus.gov)
- After the first dose, you may receive rituximab and hyaluronidase human injection under the skin, depending on how you respond to intravenous treatment with a rituximab injection product. (medlineplus.gov)
- Rituximab and hyaluronidase human injection is a synthetic (man made) antibody directed against a protein called CD20, found on the surface of normal and cancerous B-cells, which are part of the immune system. (oncolink.org)
- There are a number of things you can do to manage the side effects of rituximab and hyaluronidase human injection. (oncolink.org)
- You should not receive rituximab and hyaluronidase human injection if you have an active infection. (oncolink.org)
- Hyaluronidase can be extracted from a variety of animals, from insects, leeches, snake venom and bacteria, but is most commonly extracted from mammalian tissues, of which it is most richly found in bovine or ovine testes. (infobarrel.com)
- Amphadase® is a preparation of purified bovine testicular hyaluronidase, a protein enzyme. (rxlist.com)
- How is product H3757, Hyaluronidase from bovine testes, solubilized? (sigmaaldrich.com)
- Product H3757, Hyaluronidase from bovine testes, may be reconstituted at 1 mg/mL in 0.02 M sodium phosphate buffer, pH 7.0 containing 77mM sodium chloride and 0.01% bovine serum albumin. (sigmaaldrich.com)
- Cycling of the tumor interstitial fluid pressure was initiated by intratumoral injections of bovine testicular hyaluronidase (BTH, 1,600 U) in osteosarcoma-bearing nude mice. (nih.gov)
- Bovine testicular hyaluronidase (BTH) has been used as a spreading factor for many years and was primarily characterized by its enzymatic activity. (springer.com)
- The main goal of this thesis was the synthesis and identification of lead-like compounds and their structural optimization as inhibitors of bovine testicular hyaluronidase (BTH) and hyaluronate lyase from S. agalactiae (hylB4755). (uni-regensburg.de)
- The octadecanoate is up to 6500 times more potent than the parent compound vitamin C, and is the most potent inhibitor of bacterial and among the most potent inhibitors of bovine testicular hyaluronidase described to date. (uni-regensburg.de)
- Saturated and unsaturated hyaluronate oligosaccharides were prepared from human umbilical cord hyaluronic acid by partial digestion with bovine testicular and Streptomyces hyaluronidase, respectively. (semanticscholar.org)
- Hyaluronidase products approved by the United States Food and Drug Administration (FDA) have included those derived from bovine (AMPHADASE, [R] Amphastar Pharmaceuticals, Inc, Rancho Cucamonga, CA) and ovine(Vitrase, [R] ISTAPharmaceuticals, Inc. (thefreedictionary.com)
- To assess the effect of hyaluronidase on eye and eyelid movements when used as an adjunct in sub-Tenon's anaesthesia. (nature.com)
- The effect of hyaluronidase on ocular akinesia in sub-Tenon's anaesthesia has been reported in previous studies. (nature.com)
- The effect of hyaluronidase on myocardial ischemic injury was examined in 13 patients with acute myocardial infarction, and the results were compared with 11 patients who did not receive hyaluronidase. (annals.org)
- The addition of hyaluronidase in sub-Tenon's anaesthesia has a significant effect in improving ocular and lid (levator and orbicularis) akinesia. (nature.com)
- Our study involved a randomised double-masked trial to assess the effect of the addition of hyaluronidase on ocular motility, orbicularis and levator function in sub-Tenon's anaesthesia. (nature.com)
- The blocks were performed by one of the three operators (SAA, MTD, and LY) either with or without the addition of hyaluronidase (see Table 1 ). (nature.com)
- Multiple initial reports showed that the addition of hyaluronidase (HYAL) to chemotherapeutic regimens could greatly improve efficacy. (aacrjournals.org)
- According to this study by PRS Global , hyaluronidase injections are essential for every esthetic physician providing fillers, as it is important for managing intra-vascular hyaluronic acid (HA) filler-related cutaneous complications. (skininc.com)
- If a patient has received dermal fillers and is not happy with the result, injections of Hyaluronidase can be made to remove either some or all of the dermal filler in the treated area. (lastinglooks.ca)
- The study found that injections of hyaluronidase reduced muscle stiffness in patients with neurological injury without causing muscle weakness like conventional treatments such as botulinum toxin. (technologynetworks.com)
- Each received injections of hyaluronidase at NYU Langone's outpatient hand clinic located at the Hospital for Joint Diseases. (technologynetworks.com)
- Raghavan plans to begin a clinical trial to further study the effects of hyaluronidase in a greater number of patients, and adds that more research is needed to determine the effects of repeated hyaluronidase administrations overtime, although 15 of the 20 patients returned for additional injections. (technologynetworks.com)
- this was corrected with hyaluronidase injections. (thefreedictionary.com)
- Frontal view photograph taken 3 months after three times' hyaluronidase injections. (e-acfs.org)
- Hyaluronidases are a family of enzymes that catalyse the degradation of hyaluronic acid (HA). (wikipedia.org)
- BBI Enzymes produce high quality Hyaluronidase for use in a number of scientific studies and experiments. (infobarrel.com)
- For more information about Hyaluronidase from BBI, or a number of other enzymes, visit the BBI Enzymes website. (infobarrel.com)
- Hyaluronidase is one of a wide number of complex proteins called enzymes which to help to speed up and regulate a number of chemical reactions in living cells. (infobarrel.com)
- Hyaluronidase performs a crucial role in allowing the effects of hyaluronic acid (which is mainly found in the interstitial barrier between bodily cells) to be temporarily weakened - letting other enzymes work quickly and effectively. (infobarrel.com)
- And as Hyaluronidase limits the effective binding of Hyaluronic acid, it encourages other enzymes to move more freely around the body. (infobarrel.com)
- Synthesis of benzoyl phenyl benzoates as effective inhibitors for phospholipase A2 and hyaluronidase enzymes. (nih.gov)
- Human hyaluronidase Hyal-1 (Hyal-1) is one of the main enzymes in the metabolism of HA. (mdpi.com)
- Measurement of the electrophoretic mobility after the removal of acidic sugars by their specific enzymes suggested that hyaluronidase-sensitive negative charges were lost from the cell surface only in highly inducible clones. (aacrjournals.org)
- Hyaluronidase are enzymes that catalyze the degradation of hyaluronic acid. (transparencymarketresearch.com)
- Increase in awareness about physical appearance among people, globally, is projected to propel the use of hyaluronidase enzyme, as these enzymes are widely used in cosmetic procedures. (transparencymarketresearch.com)
- The animal-derived hyaluronidase segment dominated the market as most approved brands that are available are animal-derived enzymes. (transparencymarketresearch.com)
- Hyaluronidases have been found as the target enzymes in the development of osteoarthritis (OA) disease. (biomedcentral.com)
- Hyaluronidase is made of enzymes that catalyse the degradation of hyaluronic acid (HA). (marx-med.com)
- Hyaluronidase is a genetically designed protein. (cigna.com)
- Hyaluronidase is a genetically designed protein used as an aid in helping your body absorb other injected medications. (cigna.com)
- HYALURONIDASE (hahy uh loo RON i deys) is a natural protein. (aarp.org)
- Hyaluronidase is a hard to express protein and imposes a high metabolic burden to the host. (mdpi.com)
- The protein activity of hyaluronidase IBs was verified using (Fourier transform) FT-IR spectroscopy. (mdpi.com)
- Amino acid sequence of the purified hyaluronidase matched a cDNA in the human Expressed Sequence Tag database which, in combination with 5′-RACE-PCR, was used to clone the gene, termed HYAL1, coding for a protein of 435 amino acids. (springer.com)
- This antiserum labelled a 107-kDa protein in partially purified hyaluronidase preparations from S. pneumoniae. (asm.org)
- The encoded protein functions as a cell surface hyaluronidase that cleaves extracellular high molecular weight hyaluronan into intermediate size fragments before internalization and degradation in the lysosome. (nih.gov)
- HYALURONIDASE (hye al ur ON i dase) is a natural protein. (kramesonline.com)
- HYAL1 and HYAL2 are the major hyaluronidases in most tissues. (wikipedia.org)
- found that hyaluronidase 2 (HYAL2), an enzyme that degrades hyaluronan, promoted the production of CD44v7/8 through a mechanism that appeared to be independent of its enzymatic activity. (sciencemag.org)
- We identified an unexpected function for the ubiquitous hyaluronan-degrading enzyme, hyaluronidase 2 (HYAL2), as a regulator of CD44 splicing. (sciencemag.org)
- We have also identified two additional paralogous hyaluronidase-like genes flanking HYAL1 on chromosome 3p21.3 termed HYAL2 and HYAL3. (springer.com)
- Brand names of animal-derived hyaluronidase include Hydase (developed and manufactured by PrimaPharm Inc., distributed by Akorn Inc.), which has been FDA-approved as a "thimerosal-free" animal-derived hyaluronidase, Vitrase (Bausch + Lomb/Valeant Pharmaceuticals), Amphadase (Amphastar Pharmaceuticals), and Wydase. (wikipedia.org)
- Amphadase® (hyaluronidase injection) is supplied as a sterile, clear, colorless, ready for use solution. (rxlist.com)
- Then inject Amphadase® (hyaluronidase injection) into rubber tubing close to needle. (rxlist.com)
- With the patient prone , 75 U of Amphadase® (hyaluronidase injection) is injected subcutaneously over each scapula , followed by injection of the contrast medium at the same sites. (rxlist.com)
- Amphadase® (hyaluronidase injection) is supplied sterile as 150 USP units of hyaluronidase per mL in a 2 mL single-use glass vial with a gray rubber stopper and aluminum flip-off seal. (rxlist.com)
- Amphadase (hyaluronidase injection, USP) is indicated to increase the absorption and dispersion of other injected drugs and contraindicated where hypersensitivities to hyaluronidase or any other ingredient in the formulation exist. (eyeamphadase.com)
- n=4) were immobilized with 1 mg carfentanil and adults with 3 mg carfentanil mixed with 1500 IU of hyaluronidase. (elephantcare.org)
- d) Azaperone (60-100 mg) was combined with etorphine (7-15 mg) and hyaluronidase 1500-3000 IU) in a translocation operation of 26 elephants in central Kenya. (elephantcare.org)
- A paraben free, lyophilized powder of hyaluronidase 1500 i.u. per vial, free from oxidation. (mesobeautyslim.com)
- Content: Hyaluronidase (Ovine origin) -- 1500 I.U. Lactose hydrate -- 13.3mg. (marx-med.com)
- By catalyzing the hydrolysis of hyaluronan, a constituent of the extracellular matrix (ECM), hyaluronidase lowers the viscosity of hyaluronan, thereby increasing tissue permeability. (wikipedia.org)
- Hyaluronidase is an enzyme that depolymerises hyaluronic acid, thereby aiding the spread of the local anaesthetic through the extracellular matrix. (nature.com)
- The effect of some physical and nutritional parameters were studied for the optimum production of extracellular enzyme hyaluronidase employing Streptococcus mitis MTCC*2695 by submerged fermentation. (ijpsonline.com)
- Cell surface hyaluronidase that mediates the initial cleavage of extracellular high-molecular-weight hyaluronan into intermediate-size hyaluronan of approximately 5 kDa fragments (PubMed:28246172). (nih.gov)
- Daratumumab and hyaluronidase-fihj injection comes as a solution (liquid) to be injected subcutaneously (just under the skin) into the abdomen (stomach) over 3 to 5 minutes. (medlineplus.gov)
- Hyaluronidase is an enzyme that is used in this medication to increase the absorption of rituximab when it is given subcutaneously (into the skin). (oncolink.org)
- Hyaluronidase are extensively utilized to enhance the absorption of fluids that are injected subcutaneously or intramuscular. (transparencymarketresearch.com)
- Inject Hyaluronidase subcutaneously and leave for 20 minutes to assess allergic reactions. (marx-med.com)
- The recommended dose of Herceptin Hylecta is 600 mg/10,000 units (600 mg trastuzumab and 10,000 units hyaluronidase) administered subcutaneously over approximately 2-5 minutes once every three weeks. (centerwatch.com)
- When hematoma or fibrosis is confirmed, hyaluronidase (H-lase) 1,500 IU and 2 mL of normal saline were mixed and subcutaneously injected in crisscross manner. (e-acfs.org)
- If you have an allergy to hyaluronidase or any other part of hyaluronidase injection (human). (drugs.com)
- This is not a list of all drugs or health problems that interact with hyaluronidase injection (human). (drugs.com)
- You must check to make sure that it is safe for you to take hyaluronidase injection (human) with all of your drugs and health problems. (drugs.com)
- Tell all of your health care providers that you take hyaluronidase injection (human). (drugs.com)
- You will need to talk about the benefits and risks of using hyaluronidase injection (human) while you are pregnant. (drugs.com)
- Use hyaluronidase injection (human) as ordered by your doctor. (drugs.com)
- If you need to store hyaluronidase injection (human) at home, talk with your doctor, nurse, or pharmacist about how to store it. (drugs.com)
- Acidic hyaluronidase activity is present in mouse sperm and is reduced in the absence of SPAM1: evidence for a role for hyaluronidase 3 in mouse and human sperm. (nih.gov)
- Ultraviolet-B irradiation induces differential regulations of hyaluronidase expression and activity in normal human keratinocytes. (nih.gov)
- This new treatment includes the same monoclonal antibody as intravenous Rituxan® (rituximab) in combination with hyaluronidase human, an enzyme that helps to deliver rituximab under the skin. (roche.com)
- In light of this, we have developed an attenuated, tumor-targeting Salmonella typhimurium (ST) expressing functional bacterial hyaluronidase (bHs-ST), capable of degrading human HA deposited within PDAC tumors. (aacrjournals.org)
- We have now purified the hyaluronidase of human plasma. (springer.com)
- The mouse hyaluronidase gene, by convention termed Hyall, was also cloned and expressed and found to be 73% identical to the human enzyme. (springer.com)
- In mouse, serum hyaluronidase polymorphism has previously been mapped to 60 cM from the centromere of chromosome 9, which corresponds to a cytogenetic location of 9F1-F2, a region syntenic to the human 3p21.3. (springer.com)
- Many cells in cultures from a murine fibrosarcoma or from human embryonic lung treated in this way appear to be covered by a matrix that obscures the microvilli that are visible on critical-point-dried or hyaluronidase-treated, freeze-dried cells. (biologists.org)
- The active plant extract ( Payena dasyphylla ) was then studied for its hyaluronidase inhibitory activity in the interleukin-1β (IL-1β) stimulated human chondrocytes cell line (NHAC-kn) using zymography method. (biomedcentral.com)
- The plant extract also inhibited hyaluronidase expression in the cultured human chondrocyte cells in response to IL-1β (100 ng/ml). (biomedcentral.com)
- Hyaluronidase is an enzyme that occurs naturally in the human body. (mesobeautyslim.com)
- Each vial contains 150 USP units of hyaluronidase per mL with 8.5 mg sodium chloride, 1 mg edetate disodium, 0.4 mg calcium chloride , monobasic sodium phosphate buffer, and not more than 0.1 mg thimerosal (mercury derivative). (rxlist.com)
- Hyaluronidase and immune globulin comes in a kit that contains a "dual vial" unit. (cigna.com)
- The small vial contains hyaluronidase and the large vial contains immune globulin. (cigna.com)
- Each single-use vial (bottle) of hyaluronidase or immune globulin is for one use only. (cigna.com)
- One vial of hyaluronidase typically costs $50, and a single treatment may require 4 to 8 vials, while one vial of botulinum toxin may cost at least $500, and treatment may require up to 4 or more vials. (technologynetworks.com)
- Hyaluronidase degrades hyaluronan and has been found to be inappropriately regulated during cancer progression. (sigmaaldrich.com)
- Hyaluronidase is an enzyme which degrades hyaluronan (HA) and has diverse clinical applications resulting from its ability to facilitate the dispersion and/or absorption of an array of medications and fluids. (eyeamphadase.com)
- tell your doctor and pharmacist if you are allergic to daratumumab, hyaluronidase-fihj, any other medications, or any of the ingredients in daratumumab and hyaluronidase-fihj injection. (medlineplus.gov)
- You should not be treated with this medicine if you are allergic to hyaluronidase or rituximab. (uwhealth.org)
- You will be watched closely for at least 15 minutes after receiving hyaluronidase and rituximab, to make sure you do not have an allergic reaction. (uwhealth.org)
- In one group of patients, 150 units of hyaluronidase (HD) were injected in each ganglion cyst by a 15 gauge needle followed by a 15 min equilibration period. (deepdyve.com)
- The amount of hyaluronidase varies on the location of the condition, but it is typically suggested to use 500 U for 1 vascular territory and 1,000 U for 2 areas. (skininc.com)
- The high-dose pulsed hyaluronidase treatments works based on the concept that a sufficient amount of hyaluronidase with a high concentration level is necessary for a long duration so that it can dissolve the HA material in the affected area. (skininc.com)
- 2. If a large amount of hyaluronidase is injected, the inhibitor level is reduced to zero and hyaluronidase may be present in serum for some time after the injection. (rupress.org)
- What are some other side effects of Hyaluronidase Injection? (drugs.com)
- If you become pregnant while using this medicine or within 7 months after you stop, your name may be listed on a pregnancy registry to track the effects of hyaluronidase and trastuzumab on the baby. (cigna.com)
- What are the possible side effects of hyaluronidase and trastuzumab? (cigna.com)
- Some bacteria, such as Staphylococcus aureus, Streptococcus pyogenes, and Clostridium perfringens, produce hyaluronidase as a means of using hyaluronan as a carbon source. (wikipedia.org)
- BACKGROUND: The present study was undertaken in order to: (a) develop a new technique for measurement of interstitial pressure, (b) study the intragraft pressure of rejecting and non-rejecting organs, and (c) study the effect of treatment with the hyaluronan-degrading enzyme hyaluronidase on intragraft pressure. (biomedsearch.com)
- Treatment with hyaluronidase has previously been demonstrated to result not only in reduction of tissue hyaluronan but also in ameliorated interstitial edema, and we suggested that the diminished edema would lead to a reduced interstitial pressure as well. (biomedsearch.com)
- CONCLUSIONS: By using modern technology for tissue pressure measurements, we found that the strongly increased interstitial pressure of rejecting organs can be instantly reduced by intravenous administration of the hyaluronan-degrading enzyme hyaluronidase. (biomedsearch.com)
- According to their enzymatic mechanism, hyaluronidases are hyaluronoglucosidases (EC 184.108.40.206), i.e. they cleave the (1->4)-linkages between N-acetylglucosamine and glucuronate. (wikipedia.org)
- All the newly synthesized compounds were evaluated for their phospholipase A2 [E.C. 3.1.1.and hyaluronidase [E.C. 3.2.1.enzyme inhibitory activity in snake venom as source and their structure-activity relationship with respect to different groups is reported for the first time. (nih.gov)
- It is often speculated that Streptococcus and Staphylococcus pathogens use hyaluronidase as a virulence factor to destroy the polysaccharide that holds animal cells together, making it easier for the pathogen to spread through the tissues of the host organism, but no valid experimental data are available to support this hypothesis. (wikipedia.org)
- The aim of this study was to screen selected Malaysian plants on their anti-hyaluronidase activity as well as to evaluate the active plant and its derived fractions on its potential anti-arthritic and antioxidant activities. (biomedcentral.com)
- The role of hyaluronidases in cancer has been historically controversial due to contradictory observations, namely that levels of hyaluronidase (HYAL1/2) are increased in some cancers (colorectal, bladder, prostate, breast and brain), whereas low expression of HYAL1 is correlated with a decrease in survival of pancreatic adenocarcinoma patients. (wikipedia.org)
- Hyaluronidase deficiency (also known as "mucopolysaccharidosis type IX") is a condition caused by mutations in HYAL1, and characterized by multiple soft-tissue masses. (wikipedia.org)
- It was decided to dissolve the HA filler material using 1,000 units (U) of high-dose pulsed hyaluronidase due to the cheek and nose skin areas becoming involved in the condition. (skininc.com)
- To achieve the most satisfying results, it is always best to start off slowly with any dermal filler and there will be no need for Hyaluronidase. (lastinglooks.ca)
- Hyaluronidase reverses hyaluronic acid based dermal filler procedures by breaking down its content and dissolving the filler completely. (marx-med.com)
- Before you receive a hyaluronidase and rituximab injection, you will receive an intravenous (IV) injection of rituximab (Rituxan). (uwhealth.org)
- 1. Following intravenous administration of testes hyaluronidase in rabbits and dogs, there is a decrease in the level of the non-specific inhibitor of hyaluronidase in serum. (rupress.org)
- You should use birth control to prevent pregnancy during your treatment with daratumumab and hyaluronidase-fihj and for at least 3 months after your final dose. (medlineplus.gov)
- Rituximab/hyaluronidase should only be administered after a patient has received and tolerated at least one full dose of IV rituximab. (lww.com)
- The hyaluronidase and immune globulin kit comes with patient instructions for preparing and injecting your dose. (cigna.com)
- Do not breast-feed while using hyaluronidase and rituximab, and for at least 6 months after your last dose. (uwhealth.org)
- You may need to keep taking anti-infective medication for up to 12 months after your last dose of hyaluronidase and rituximab. (uwhealth.org)
- Call your doctor for instructions if you miss a dose of hyaluronidase and rituximab. (uwhealth.org)
- The dose of hyaluronidase varies in different clinical situations. (asahq.org)
- Sixteen adult female free-ranging elephants were immobilized in July 1990, using a mean (±SE) dose per animal of 11.6 ± 0.3 mg of etorphine (M99) mixed with a standard dose of hyaluronidase (4500 IU), at the Sengwa Wildlife Research Area, Zimbabwe, to attach telemetry and infrasound detection collars. (elephantcare.org)
- The 16 elephants were reimmobilized in December 1990, using higher doses of etorphine (standardized at 15 mg total dose) with hyaluronidase (4500 IU), to remove the collars. (elephantcare.org)
- Degradation process of hyaluronic acid by Streptomyces hyaluronidase. (semanticscholar.org)
- After treatment with Streptomyces hyaluronidase, the distribution of degradation products from these oligosaccharides was determined. (semanticscholar.org)
- Thus, natural agents that delay free - radical catalyzed degradation or acting for as inhibitors of hyaluronidase enzyme are useful to maintain the integrity of dermal HA. (ijpni.org)
- To support this model a series of benzoxazole derivatives was synthesized and investigated for hyaluronidase inhibition. (uni-regensburg.de)
- Materials and Methods: In this study, water soluble peripherally and non-peripherally tetra substituted novel zinc (II) phthalocyanines, which were tagged as ZnPC, investigated against the inhibition of urease and hyaluronidase (HYA). (eurekaselect.com)
- What is the most important information I should know about hyaluronidase and trastuzumab? (cigna.com)
- Hyaluronidase and trastuzumab is a combination medicine used to treat certain types of breast cancer. (cigna.com)
- Hyaluronidase and trastuzumab may also be used for purposes not listed in this medication guide. (cigna.com)
- What should I discuss with my healthcare provider before receiving hyaluronidase and trastuzumab? (cigna.com)
- Do not use hyaluronidase and trastuzumab if you are pregnant. (cigna.com)
- How is hyaluronidase and trastuzumab given? (cigna.com)
- Hyaluronidase and trastuzumab is usually given for 1 year, or until your body no longer responds to the medicine. (cigna.com)
- Hyaluronidase and trastuzumab can have long lasting effects on your body. (cigna.com)
- Call your doctor for instructions if you miss an appointment for your hyaluronidase and trastuzumab injection. (cigna.com)
- What should I avoid while receiving hyaluronidase and trastuzumab? (cigna.com)
- The graph below shows some benefits to using Lidocaine along with Hyaluronidase. (eyeamphadase.com)
- that is the same mixture to which 150 IU of hyaluronidase was added Group C received the solution of LBtempi8 / that is plain 1: 2 mixture of lidocaine-bupivacaine warmed to a temperature of 38C. (bu.edu.eg)
- citation needed] Hyaluronidases are also thought to play a role in the process of angiogenesis, although most hyaluronidase preparations are contaminated with large amounts of angiogenic growth factors. (wikipedia.org)
- Fluid , Electrolyte Preparations Salt Name : OR Generic Name Form Price : MRP /Probable Packing Hyaluronidase INJ Rs. (medicscientist.com)
- Mouse Hyal3 encodes a 45- to 56-kDa glycoprotein whose overexpression increases hyaluronidase 1 activity in cultured cells. (nih.gov)
- Regulation of hyaluronidase activity by alternative mRNA splicing. (nih.gov)
- To investigate the role of HA in the development of spontaneous neuronal network activity, we used microelectrode array recording and Ca 2 + imaging in hippocampal cultures enzymatically treated with hyaluronidase. (frontiersin.org)
- Our findings revealed an appearance of epileptiform activity 9 days after hyaluronidase treatment. (frontiersin.org)
- The changes in Ca 2 + transients in hyaluronidase-treated neurons were more prominent then in astrocytes and preceded changes in electrical activity. (frontiersin.org)
- This procedure is a turbidimetric determination (% Transmittance at 600 nm, Light path = 1 cm) of Hyaluronidase activity. (sigmaaldrich.com)
- We show that clinical GBS strains associated with preterm labor or neonatal infections have increased hyaluronidase activity compared to commensal strains obtained from rectovaginal swabs of healthy women. (asm.org)
- Using a murine model of ascending infection, we show that hyaluronidase activity was associated with increased ascending GBS infection, preterm birth, and fetal demise. (asm.org)
- Interestingly, hyaluronidase activity reduced uterine inflammation but did not impact placental or fetal inflammation. (asm.org)
- Our study shows that hyaluronidase activity enables GBS to subvert uterine immune responses, leading to increased rates of ascending infection and preterm birth. (asm.org)
- Hence, Seminal Hyaluronidase Activity (SHA) and Hypo-osmotic Swelling (HOS score) of sperms that evaluate healthy sperms of fertilizing potential, were studied in male partners of infertile couples. (ebscohost.com)
- However, data on the pH-dependent activity of hyaluronidases reported in literature are inconsistent in part or even contradictory. (springer.com)
- An excellent option to consider is the Hyaluronidase, Glass Bottle, Activity: 300NF U/mg min. (medexsupply.com)
- One immunoreactive clone was isolated, and it produced high level of hyaluronidase activity. (asm.org)
- The hyaluronidase activity in this pneumococcal extract was also neutralized by the antiserum. (asm.org)
- The hyaluronidase activity of such samples of serum increases when the serum is incubated with papain. (rupress.org)
- 3. Hyaluronidase activity is found in the livers of the injected animals in large amounts and this activity is increased considerably when the homogenate of this tissue is incubated with papain. (rupress.org)
- The inhibitory activities on both hyaluronidases were determined by means of a turbidimetric assay and the structure-activity relationships were elaborated. (uni-regensburg.de)
- Using the transglycosylation activity of hyaluronidase , it has been confirmed that both natural and unnatural GAG chains can be synthesized. (thefreedictionary.com)
- hyaluronidase activity is a methylxanthine, which reverses the positive benefits out of clonidine at recollecting the cellular level. (evolutionvideoinc.com)
- Potent and selective inhibitors of hyaluronidases are not reported in the literature so far. (uni-regensburg.de)
- Four 6-O-acyl derivatives of L-ascorbic acid were identified as moderate to strong inhibitors of hyaluronidases with preference for the bacterial enzyme. (uni-regensburg.de)
- Few reports concerning hyaluronidase inhibitors from natural source. (ijpni.org)
- This article presents the reported potent herbal hyaluronidase enzyme inhibitors worldwide and most reported Egyptian products. (ijpni.org)
- hyaluronidase increases the distribution/dispersion and absorption of locally injected or extravasated substances. (drugs.com)
- Limited data support a role of lysosomal hyaluronidases in metastasis, while other data support a role in tumor suppression. (wikipedia.org)
- It has been hypothesized that, by helping degrade the ECM surrounding the tumor, hyaluronidases help cancer cells escape from primary tumor masses. (wikipedia.org)
- Mice with alleles of Hyall producing higher levels of plasma hyaluronidase have greater resistance to transplanted tumor growth. (springer.com)