Foreskin: The double-layered skin fold that covers the GLANS PENIS, the head of the penis.Skin: The outer covering of the body that protects it from the environment. It is composed of the DERMIS and the EPIDERMIS.Phimosis: A condition in which the FORESKIN cannot be retracted to reveal the GLANS PENIS. It is due to tightness or narrowing of the foreskin opening.Skin Aging: The process of aging due to changes in the structure and elasticity of the skin over time. It may be a part of physiological aging or it may be due to the effects of ultraviolet radiation, usually through exposure to sunlight.Circumcision, Male: Excision of the prepuce of the penis (FORESKIN) or part of it.Fibroblasts: Connective tissue cells which secrete an extracellular matrix rich in collagen and other macromolecules.Keratinocytes: Epidermal cells which synthesize keratin and undergo characteristic changes as they move upward from the basal layers of the epidermis to the cornified (horny) layer of the skin. Successive stages of differentiation of the keratinocytes forming the epidermal layers are basal cell, spinous or prickle cell, and the granular cell.Balanitis: Inflammation of the head of the PENIS, glans penis.Penis: The external reproductive organ of males. It is composed of a mass of erectile tissue enclosed in three cylindrical fibrous compartments. Two of the three compartments, the corpus cavernosa, are placed side-by-side along the upper part of the organ. The third compartment below, the corpus spongiosum, houses the urethra.Skin Neoplasms: Tumors or cancer of the SKIN.Skin DiseasesSkin Physiological Phenomena: The functions of the skin in the human and animal body. It includes the pigmentation of the skin.Epidermis: The external, nonvascular layer of the skin. It is made up, from within outward, of five layers of EPITHELIUM: (1) basal layer (stratum basale epidermidis); (2) spinous layer (stratum spinosum epidermidis); (3) granular layer (stratum granulosum epidermidis); (4) clear layer (stratum lucidum epidermidis); and (5) horny layer (stratum corneum epidermidis).Penile Diseases: Pathological processes involving the PENIS or its component tissues.Skin Absorption: Uptake of substances through the SKIN.Dermis: A layer of vascularized connective tissue underneath the EPIDERMIS. The surface of the dermis contains innervated papillae. Embedded in or beneath the dermis are SWEAT GLANDS; HAIR FOLLICLES; and SEBACEOUS GLANDS.Cells, Cultured: Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.Skin Pigmentation: Coloration of the skin.Ultraviolet Rays: That portion of the electromagnetic spectrum immediately below the visible range and extending into the x-ray frequencies. The longer wavelengths (near-UV or biotic or vital rays) are necessary for the endogenous synthesis of vitamin D and are also called antirachitic rays; the shorter, ionizing wavelengths (far-UV or abiotic or extravital rays) are viricidal, bactericidal, mutagenic, and carcinogenic and are used as disinfectants.Paraphimosis: A condition in which the FORESKIN, once retracted, cannot return to its original position. If this condition persists, it can lead to painful constriction of GLANS PENIS, swelling, and impaired blood flow to the penis.Skin, Artificial: Synthetic material used for the treatment of burns and other conditions involving large-scale loss of skin. It often consists of an outer (epidermal) layer of silicone and an inner (dermal) layer of collagen and chondroitin 6-sulfate. The dermal layer elicits new growth and vascular invasion and the outer layer is later removed and replaced by a graft.Hypospadias: A birth defect due to malformation of the URETHRA in which the urethral opening is below its normal location. In the male, the malformed urethra generally opens on the ventral surface of the PENIS or on the PERINEUM. In the female, the malformed urethral opening is in the VAGINA.Skin Tests: Epicutaneous or intradermal application of a sensitizer for demonstration of either delayed or immediate hypersensitivity. Used in diagnosis of hypersensitivity or as a test for cellular immunity.Skin Transplantation: The grafting of skin in humans or animals from one site to another to replace a lost portion of the body surface skin.Erythema: Redness of the skin produced by congestion of the capillaries. This condition may result from a variety of causes.Melanocytes: Mammalian pigment cells that produce MELANINS, pigments found mainly in the EPIDERMIS, but also in the eyes and the hair, by a process called melanogenesis. Coloration can be altered by the number of melanocytes or the amount of pigment produced and stored in the organelles called MELANOSOMES. The large non-mammalian melanin-containing cells are called MELANOPHORES.Keratins: A class of fibrous proteins or scleroproteins that represents the principal constituent of EPIDERMIS; HAIR; NAILS; horny tissues, and the organic matrix of tooth ENAMEL. Two major conformational groups have been characterized, alpha-keratin, whose peptide backbone forms a coiled-coil alpha helical structure consisting of TYPE I KERATIN and a TYPE II KERATIN, and beta-keratin, whose backbone forms a zigzag or pleated sheet structure. alpha-Keratins have been classified into at least 20 subtypes. In addition multiple isoforms of subtypes have been found which may be due to GENE DUPLICATION.Langerhans Cells: Recirculating, dendritic, antigen-presenting cells containing characteristic racket-shaped granules (Birbeck granules). They are found principally in the stratum spinosum of the EPIDERMIS and are rich in Class II MAJOR HISTOCOMPATIBILITY COMPLEX molecules. Langerhans cells were the first dendritic cell to be described and have been a model of study for other dendritic cells (DCs), especially other migrating DCs such as dermal DCs and INTERSTITIAL DENDRITIC CELLS.Administration, Topical: The application of drug preparations to the surfaces of the body, especially the skin (ADMINISTRATION, CUTANEOUS) or mucous membranes. This method of treatment is used to avoid systemic side effects when high doses are required at a localized area or as an alternative systemic administration route, to avoid hepatic processing for example.Papillomaviridae: A family of small, non-enveloped DNA viruses infecting birds and most mammals, especially humans. They are grouped into multiple genera, but the viruses are highly host-species specific and tissue-restricted. They are commonly divided into hundreds of papillomavirus "types", each with specific gene function and gene control regions, despite sequence homology. Human papillomaviruses are found in the genera ALPHAPAPILLOMAVIRUS; BETAPAPILLOMAVIRUS; GAMMAPAPILLOMAVIRUS; and MUPAPILLOMAVIRUS.Cell Line: Established cell cultures that have the potential to propagate indefinitely.Haemophilus ducreyi: A species of HAEMOPHILUS that appears to be the pathogen or causative agent of the sexually transmitted disease, CHANCROID.Oncogene Proteins, Viral: Products of viral oncogenes, most commonly retroviral oncogenes. They usually have transforming and often protein kinase activities.Sunlight: Irradiation directly from the sun.Collagen: A polypeptide substance comprising about one third of the total protein in mammalian organisms. It is the main constituent of SKIN; CONNECTIVE TISSUE; and the organic substance of bones (BONE AND BONES) and teeth (TOOTH).Dermatitis: Any inflammation of the skin.Wound Healing: Restoration of integrity to traumatized tissue.Skin Physiological Processes: Biological activities and functions of the SKIN.Administration, Cutaneous: The application of suitable drug dosage forms to the skin for either local or systemic effects.RNA, Messenger: RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.Sebaceous Glands: Small, sacculated organs found within the DERMIS. Each gland has a single duct that emerges from a cluster of oval alveoli. Each alveolus consists of a transparent BASEMENT MEMBRANE enclosing epithelial cells. The ducts from most sebaceous glands open into a HAIR FOLLICLE, but some open on the general surface of the SKIN. Sebaceous glands secrete SEBUM.Skin UlcerCell Division: The fission of a CELL. It includes CYTOKINESIS, when the CYTOPLASM of a cell is divided, and CELL NUCLEUS DIVISION.Skin Diseases, Bacterial: Skin diseases caused by bacteria.Melanins: Insoluble polymers of TYROSINE derivatives found in and causing darkness in skin (SKIN PIGMENTATION), hair, and feathers providing protection against SUNBURN induced by SUNLIGHT. CAROTENES contribute yellow and red coloration.Chancroid: Acute, localized autoinoculable infectious disease usually acquired through sexual contact. Caused by HAEMOPHILUS DUCREYI, it occurs endemically almost worldwide, especially in tropical and subtropical countries and more commonly in seaports and urban areas than in rural areas.Immunohistochemistry: Histochemical localization of immunoreactive substances using labeled antibodies as reagents.Blister: Visible accumulations of fluid within or beneath the epidermis.Papillomavirus E7 Proteins: ONCOGENE PROTEINS from papillomavirus that deregulate the CELL CYCLE of infected cells and lead to NEOPLASTIC CELL TRANSFORMATION. Papillomavirus E7 proteins have been shown to interact with various regulators of the cell cycle including RETINOBLASTOMA PROTEIN and certain cyclin-dependent kinase inhibitors.Sunscreening Agents: Chemical or physical agents that protect the skin from sunburn and erythema by absorbing or blocking ultraviolet radiation.Mice, Hairless: Mutant strains of mice that produce little or no hair.Cytomegalovirus: A genus of the family HERPESVIRIDAE, subfamily BETAHERPESVIRINAE, infecting the salivary glands, liver, spleen, lungs, eyes, and other organs, in which they produce characteristically enlarged cells with intranuclear inclusions. Infection with Cytomegalovirus is also seen as an opportunistic infection in AIDS.Feeder Cells: Cells used in COCULTURE TECHNIQUES which support the growth of the other cells in the culture. Feeder cells provide auxillary substances including attachment substrates, nutrients, or other factors that are needed for growth in culture.Carcinoma, Basal Cell: A malignant skin neoplasm that seldom metastasizes but has potentialities for local invasion and destruction. Clinically it is divided into types: nodular, cicatricial, morphaic, and erythematoid (pagetoid). They develop on hair-bearing skin, most commonly on sun-exposed areas. Approximately 85% are found on the head and neck area and the remaining 15% on the trunk and limbs. (From DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1471)Sweat Glands: Sweat-producing structures that are embedded in the DERMIS. Each gland consists of a single tube, a coiled body, and a superficial duct.Uganda: A republic in eastern Africa, south of SUDAN and west of KENYA. Its capital is Kampala.Injections, Intradermal: The forcing into the skin of liquid medication, nutrient, or other fluid through a hollow needle, piercing the top skin layer.Keratosis: Any horny growth such as a wart or callus.Hair Follicle: A tube-like invagination of the EPIDERMIS from which the hair shaft develops and into which SEBACEOUS GLANDS open. The hair follicle is lined by a cellular inner and outer root sheath of epidermal origin and is invested with a fibrous sheath derived from the dermis. (Stedman, 26th ed) Follicles of very long hairs extend into the subcutaneous layer of tissue under the SKIN.Gene Expression: The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.Psoriasis: A common genetically determined, chronic, inflammatory skin disease characterized by rounded erythematous, dry, scaling patches. The lesions have a predilection for nails, scalp, genitalia, extensor surfaces, and the lumbosacral region. Accelerated epidermopoiesis is considered to be the fundamental pathologic feature in psoriasis.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Time Factors: Elements of limited time intervals, contributing to particular results or situations.Cell Differentiation: Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs.Cell Culture Techniques: Methods for maintaining or growing CELLS in vitro.Staphylococcal Skin Infections: Infections to the skin caused by bacteria of the genus STAPHYLOCOCCUS.Bandages, Hydrocolloid: Dressings comprised of a self-adhesive matrix to which hydrophilic absorbent particles are embedded. The particles consist of CELLULOSE derivatives; calcium ALGINATES; PECTINS; or GELS. The utility is based on providing a moist environment for WOUND HEALING.
Doris Taylor's heart in a jar Tissue-engineered airway Tissue-engineered vessels Artificial skin constructed from human skin ... Artificial bone marrow Artificial bone Laboratory-grown penis Oral mucosa tissue engineering Foreskin Tissue engineering ... An artificial organ is a man-made device that is implanted or integrated into a human to replace a natural organ, for the ... "Artificial Penis Tissue Proves Promising in Lab Tests". "Epistem.co.uk can create foreskin". Archived from the original on 2013 ...
According to research, the foreskin comprises over half of the skin and mucosa of the human penis. In some men, foreskin ... Examples of such artificial coverings include a prosthetic foreskin made of latex that covers the glans in a moist environment ... no human foreskin has yet been regenerated, nor has one been attached to a human. There can be no assurance that human foreskin ... This option, unlike foreskin restoration, would result in a true human male foreskin being regrown. Pioneers in the field of ...
Epithelium of the penis consists of the shaft skin, the foreskin, and the preputial mucosa on the inside of the foreskin and ... When model penises without a coronal ridge were used, less than half the artificial sperm was displaced, compared to penises ... "A culture system using human foreskin fibroblasts as feeder cells allows production of human embryonic stem cells". Human ... After hospital circumcision, the foreskin may be used in biomedical research, consumer skin-care products, skin grafts, or β- ...
Epithelium of the penis consists of the shaft skin, the foreskin, and the preputial mucosa on the inside of the foreskin and ... Research has studied how much semen is displaced by different shaped, artificial genitals.[45] This research showed that, when ... "A culture system using human foreskin fibroblasts as feeder cells allows production of human embryonic stem cells". Human ... consumer skin-care products,[67] skin grafts,[68][69][70] or β-interferon-based drugs.[71] In parts of Africa, the foreskin may ...
Labia elongation Foreskin restoration Human branding - controlled burning or cauterizing of tissue to encourage intentional ... skinning, and wheeling[citation needed]. Some surgical procedures that modify human genitals are performed with the informed ... Body piercing - permanent placement of jewelry through an artificial fistula; sometimes further modified by stretching Ear ... Body modification (or body alteration) is the deliberate altering of the human anatomy or human physical appearance. It is ...
... as the cells in foreskin normally don't grow hair. The human skin samples were grafted on rats. After six weeks the cloned ... The first time scientists were able to grow artificial hair follicles from stem cells was in 2010. Scientists of the Berlin ... In 2016, scientists in Japan announced they had successfully grown human skin in a lab. The skin was created using induced ... They chose to try the method by injecting the cloned cells in foreskin samples to "challenge" the cells, ...
Circumcision Ethics of circumcision FGM Foreskin Foreskin Man Foreskin restoration History of circumcision Human genital ... pulling its skin downward. Overtime, a new foreskin was generated, or a short prepuce was lengthened, by means of tissue ... or the Artificial Changeling, wrote of the loss in sexual pleasure resulting from circumcision: "the part which hangeth over ... Paige KE (May 1978). "The Ritual of Circumcision". Human Nature: 40-48. Gairdner DM (1949). "The fate of the foreskin: a study ...
But if the son removed the compress, his skin would break out in sores. Even so, did God tell Israel that God created the Evil ... "Artificial Insemination, Egg Donation and Adoption." New York: Rabbinical Assembly, 1994. EH 1:3.1994. Reprinted in Responsa: ... How can a human being walk after God, when Deuteronomy 4:24 says, "[T]he Lord your God is a devouring fire"? Rabbi Hama son of ... "Circumcise therefore the foreskin of your heart." David called it "Unclean" in Psalm 51:12; Solomon called it "the Enemy" in ...
Artificial Skin: The skin generated in vitro is in fact the epidermis portion of skin only; when the epidermis is applied to ... the burnt part, this leads to the regeneration of dermis (remaining parts of skin) beneath. But improvements in the appro ... The skin explants used for attaining artificial skin may be either obtained from the patient concerned or from the foreskin ( ... Artificial skin from newborn skin explants is used to wrap the wound until the patients skin is cultured and artificial skin ...
Doris Taylors heart in a jar Tissue-engineered airway Tissue-engineered vessels Artificial skin constructed from human skin ... Artificial bone marrow Artificial bone Laboratory-grown penis Oral mucosa tissue engineering Foreskin Tissue engineering ... An artificial organ is a man-made device that is implanted or integrated into a human to replace a natural organ, for the ... "Artificial Penis Tissue Proves Promising in Lab Tests". "Epistem.co.uk can create foreskin". Archived from the original on 2013 ...
... foreskin have been "seeded." On top of that layer is an epidermal layer ofthe cultured human skin cells. It is formed into 4 x ... Artificial skin, a synthetic equivalent to human skin, can dramatically increase the chance of survival of severely burned ... As the new skin grows, the cowhide and shark substances from the artificial skin are broken down and absorbed by the body. In ... After peeling away her burned skin, Burke applied a layer of artificial skin and, where possible, grafted to it some of her own ...
Snippets of infant foreskin are used for generating artificial skin. Biopsied tissues are used to manufacture therapeutic ... Human tissue, organs and cells are used in place of animal tissue for testing pharmaceuticals and cosmetics because animals are ... This language reflects the growing ability to transform human tissue into research materials and clinical products. Blood can ... Kiotech, a British biotech firm, harvests human sweat to extract pheromones for a product called "Xcite," towelettes saturated ...
... comparable acceleration in efforts to reverse-engineer the human brain and other sources of the templates of intelligence; ... which has isolated stem cells from human placentas), foreskins from circumcisions for making artificial skin for wound repair, ... New technology for digitally modeling hair, cloth, skin and muscles will make digital humans even more prevalent and ... For example, draft sequences of the entire human genome led to the surprising discovery that the human gene count was low-only ...
... foreskins will be sold illicitly to the global cosmetics industry. The KwaZulu-Natal department of health said last year that ... Discarded human foreskins are used in the cosmetics industry, in the manufacture of insulin and artificial skin, the Medical ... All foreskins are incinerated. No foreskins are sold to the cosmetics industry. Doing so would be against the Human Tissue Act ... In spite of the fact that the South African Human Tissue Act requires that researchers obtain a permit from the South African ...
... is the process of expanding the residual skin on the penis, via surgical or non- ... According to research, the foreskin comprises over half of the skin and mucosa of the human penis [1]. ... Artificial Foreskins. Vifian Atlas sells "the worlds first prosthetic foreskin". It is a latex undergarmet that protects the ... Surgical methods of foreskin restoration, sometimes known as foreskin reconstruction, usually involve a method of grafting skin ...
All boys are born with a covering of skin over the head of their penis called a foreskin. For cultural, religious or perceived ... Baby foreskins are used to research rubella, varicella and human papillomavirus (HPV) vaccines. They are used to make ... Zero artificial sweeteners, colors or alcohol. Learn more at the Health Ranger Store and help support this news site. ... Since the tissue of the foreskin is rich in human fibroblast and other cells, greedy pharmaceutical development giants are ...
Growing skin in a lab can allow scientists to create a sheet of skin 100 times the size of the original sample. Learn about ... Artificial skin derived from foreskins is thought to be successful when donor skin is not because the newborns cells dont ... For example, German research organization Fraunhofer-Gesellschaft has announced plans to grow skin from the stem cells in human ... The artificial skin membrane developed by Burke and Yannas made it easier to apply skin grafts to a burn victim, but there was ...
See how lab-grown skin is made and how it works. ... Lab-grown skin can improve the survival odds of someone with a ... Artificial skin derived from foreskins is thought to be successful when donor skin is not because the newborns cells dont ... For example, German research organization Fraunhofer-Gesellschaft has announced plans to grow skin from the stem cells in human ... The artificial skin membrane developed by Burke and Yannas made it easier to apply skin grafts to a burn victim, but there was ...
According to research, the foreskin comprises over half of the skin and mucosa of the human penis. In some men, foreskin ... Examples of such artificial coverings include a prosthetic foreskin made of latex that covers the glans in a moist environment ... no human foreskin has yet been regenerated, nor has one been attached to a human. There can be no assurance that human foreskin ... This option, unlike foreskin restoration, would result in a true human male foreskin being regrown. Pioneers in the field of ...
Artificial skin constructed from human skin cells embedded in a hydrogel, such as in the case of bioprinted constructs for ... from human foreskin has been demonstrated to be immunologically safe and thus a viable choice for tissue engineering of skin. ... An artificial organ is a man-made device that is implanted or integrated into a human to replace a natural organ, for the ... only human skin tissue has been synthesized, though researchers project that "by integrating further cell types (e.g. ...
The skin provides a dynamic barrier separating and protecting human body from the exterior world, and then immediate repair and ... human foreskin primary fibroblasts VH-Fib, human embryonic kidney HEK-293, human bone cell line U-2-OS, Chinese hamster ovary ... Human foreskin fibroblasts from a commercial source were reprogrammed into induced pluripotent stem cells to establish a clonal ... The described cells provide a useful resource in combination with other iPS cell lines generated from normal human foreskin ...
Although most surgeons prefer to use skin donated from another person (known as cadaver skin, or human allograft), skin ... It consists of human cells from circumcised infant foreskin, and grown on nylon mesh, combined with a synthetic epidermal layer ... Several artificial skin products are available for nonhealing wounds or burns such as: Apligraft® (Norvartis), Demagraft®, ... The mesh material is gradually absorbed and the human cells grow and replace the damaged skin after being placed on the wound ...
Studies on human inoculation with syphilis demonstrated the value of intact, healthy skin and mucous membrane in preventing ... The foreskin was retracted and the glans placed on a stretch over the forefinger of the left hand of the physician. Using the ... One patient fled after his penis was scarified for artificial inoculation. Dr Cutlers justification for this is a ... To settle the human issue quickly it would be necessary to shoot living syphilis germs into human bodies, just as Dr Eagle shot ...
18] In the West, biotissue companies use amputated newborn foreskins to create profitable artificial skin products. [19] So, ... then humans should follow suit. They made the simple equation: snake skin = foreskin, and the operation began. From there it ... Fourthly, slack skin on the shaft of the erect penis allows it to glide within its own sheath of skin. ... The child should be instructed that his foreskin will eventually retract. The first person to retract the foreskin should be ...
... is unique in human physiology: It allows the man to roll the skin of his penis against itself, either during sex or just by ... often requiring the repeated addition of artificial lubricant (this is no joke: its a real problem for me). Another common ... In fact, the human penis has a more innervated and well-developed foreskin when compared to other mammals -- including our ... The foreskin (or prepuce) is a mans most sensitive erogenous zone, more well-developed in humans than in other species of ...
... www.nydailynews.com/life-style/health/german-scientists-grow-artificial-skin-cells-baby-foreskins-article-1.994464. The ... fosters the growth of the foreskins cells into an epidermis layer of skin (the outermost skin on the human body). Three layers ... Weve seen foreskin taken from infant babies and used in skin grafting for burn victims. Now a laboratory dubbed the "Skin ... Stealing Foreskins: The Science of Skin Grafting. http://www.drmomma.org/2009/12/stealing-foreskins-science-of-skin.html. ~~~~ ...
... necessary body parts and not just a useless flap of skin. Feel free to add your own ... off an obvious gag on a site as a means by which to ignore the rest so I thought I would create a list here of why foreskins ... see explanation]. All of the human mucosa (the linings of the mouth, eyelids, vagina, foreskin and anus) are the bodys first ... dragging vaginal lubricants out into the drying air and making artificial lubricants essential for non-painful intercourse [6]. ...
Epithelium of the penis consists of the shaft skin, the foreskin, and the preputial mucosa on the inside of the foreskin and ... Research has studied how much semen is displaced by different shaped, artificial genitals.[45] This research showed that, when ... "A culture system using human foreskin fibroblasts as feeder cells allows production of human embryonic stem cells". Human ... consumer skin-care products,[67] skin grafts,[68][69][70] or β-interferon-based drugs.[71] In parts of Africa, the foreskin may ...
A new approach to hair growth by cloning follicles and using discarded infant foreskins has shown some early success in lab ... When scientists grafted the newly grown human skin tissue complete with donated human papillae, they saw hair growth in five of ... and artificial hair replacement with hair systems. ... Infant Foreskins may Provide New Baldness Treatment. by Sheela ... Infant foreskin was chosen "because it would challenge the human dermal papillae not just to contribute to hair follicles ...
There are other reports using human fibroblast. Human fetal limb and postnatal foreskin were changed to human induced neurons ( ... Also human induced dopaminergic neurons (hiDAs) from human prenatal lung and adult skin cell could be generated by Ascl1, Nurr1 ... but human cells were more resistant to the artificial processing. Moreover, adult had more stable epigenetic programs and ... 16] made human induced neural progenitor cells (hiNPs) with miR-9/9, miR-124, and Neurod2 from human neonatal foreskin and ...
In the skin equivalent model, the epidermis thickness was increased by 39%; additionally, in organ culture, not only was the ... Korean scientists have developed an ultrathin flexible optoelectronic device for use in patches that can be worn on the skin to ... wearable and disposable are attracting considerable attention as they can be placed close to the skin, providing an effective ... skin area increased by 14%, but also, re-epithelialization was highly induced. Based on the results, the STOLED is expected to ...
Foreskin fibroblasts are big business. A fibroblast is a piece of human skin that is used as a culture to grow other skin or ... He states categorically that only the growth hormone that is left over from growing artificial skin (not actual tissue or skin ... Human foreskin fibroblast is used in all kinds of medical procedures such as growing skin for burn victims and for eyelid ... Foreskins were used because that is a common surgery and the skin is thrown away; so, why not use it for benefits? Twelve years ...
Foreskin fibroblasts are big business. A fibroblast is a piece of human skin that is used as a culture to grow other skin or ... He states categorically that only the growth hormone that is left over from growing artificial skin (not actual tissue or skin ... Human foreskin fibroblast is used in all kinds of medical procedures such as growing skin for burn victims and for eyelid ... Foreskins were used because that is a common surgery and the skin is thrown away; so, why not use it for benefits? Twelve years ...
  • Men using this technique report fast skin regenerative growth, and in particular it is thought to be beneficial to stimulate growth of inner skin (mucous membrane) tissues which are vital to restoring the lubrication function of the foreskin. (wikipedia.org)
  • We have learned so much more about the important function of the foreskin ( and the lasting effects of early trauma on an infant ) that the common myths of the past have been discredited. (butterflybirth.com)
  • Since the tissue of the foreskin is rich in human fibroblast and other cells , greedy pharmaceutical development giants are eager to snatch it up. (naturalnews.com)
  • Also, the double-layered tissue of the foreskin engorges with blood during erection and creates a visibly and sensually thicker shaft and glans.When the engorged foreskin retracts behind the coronal ridge of the glans, it often creates a wider and more pronounced 'ridge' that many partners find especially stimulating during penetrative intercourse. (bubhub.com.au)
  • Also, the double-layered tissue of the foreskin engorges with blood during erection and creates a visibly and sensually thicker shaft and glans. (butterflybirth.com)
  • The potential for surgical error, death and extreme emotional trauma, combined with the likelihood that their baby boy's foreskin could be sold to a pharmaceutical company - even if he dies - will likely have many parents reconsidering the decision to circumcise their boys. (naturalnews.com)
  • The process itself takes six weeks to complete, and during this time 10 million skin cells are grown from one single boy's foreskin - to make new skin up to five millimeters thick. (drmomma.org)
  • Hospital trials included burn victims, patients needing skin grafts after cancer surgery, and those with chronic nonhealing wounds. (faqs.org)
  • In a study of 85 burn patients, Dermagraft, used as a temporary skin until permanent skin grafts could be done, cutthe need for surgery in half and reduced hospital stays my months. (faqs.org)
  • The artificial skin membrane developed by Burke and Yannas made it easier to apply skin grafts to a burn victim, but there was still the challenge of where to get the new skin. (howstuffworks.com)
  • Doctors also tried using skin from cadavers, donors from the victim's family and even other species, but the patient's immune system usually rejected these grafts. (howstuffworks.com)
  • In the 1970s, after deciding to perform routine skin excisions, doctors needed a skin covering that could serve as a layer of skin and protect a burned body, and they needed more sources for skin grafts. (howstuffworks.com)
  • This method has been shown to resist the recurrence of scarring, compared to the use of traditional skin grafts. (scielo.org.za)
  • Artificial skin grafts have been used to successfully repair several types of skin defects, including chronic skin ulcers. (expertsmind.com)
  • Treatment of the full-thickness wounds created on the back of nude mice with various grafts (acellular nanofiber meshes, dermal substitutes , skin substitutes and autografts) revealed that 14-day-cultured skin substitutes facilitated a rapid wound closure with complete epithelialization comparable to autografts. (nih.gov)
  • tives for autologous skin grafts including allogeneic skin, Skin as the multi-functional and protective barrier in xenografts and synthetic skin substitutes have been widely human contains essential stem cell population and vari- adopted in burn wound care [3, (deepdyve.com)
  • Meanwhile, Ioannis Yannas had been studying collagen, aprotein found in human skin. (faqs.org)
  • The pair then created a kind of artificial skin using polymers from shark cartilage and collagen from cowhide. (faqs.org)
  • This research has produced a product called Graftskin --a living skin equivalent made of purified bovine collagen into which dermal cells from infant boys' foreskin have been "seeded. (faqs.org)
  • A fourth company, Integra LifeSciences, does not clone skin but manufactures a matrix from collagen and shark cartilage with appropriate pore size and absorption rate for a wide rangeof human body parts. (faqs.org)
  • In spite of the fact that the South African Human Tissue Act requires that researchers obtain a permit from the South African Ministry of Health to export human tissues, this law is difficult to enforce,' the letter continues. (timeslive.co.za)
  • Researchers are also using foreskin to create a human telomerase reverse transcriptase (hTERT) immortalized cell line [hTERT involves combining the in vivo nature of primary cells with traditional cells' ability to survive continuously in vitro] for use in vaccines . (naturalnews.com)
  • Researchers have had success growing new skin from the patient's own skin cells. (howstuffworks.com)
  • At the time, researchers could replicate most of the various kinds of skin cells, but they couldn't get them to work together the way that healthy skin does. (howstuffworks.com)
  • Project spokesperson, Andreas Traube, says researchers hope that this use of human foreskin could replace animal testing, and eventually be used in developing treatments for cancer, pigmentation diseases, and certain skin allergies. (drmomma.org)
  • Just as the foreskin is valuable to researchers when amputated from babies and toddlers, it is of even more value when it remains on the body to which it belongs. (drmomma.org)
  • These researchers are trafficking in stolen human body parts. (drmomma.org)
  • A new approach to hair growth by cloning follicles and using discarded infant foreskins has shown some early success in lab mice, say researchers. (medindia.net)
  • Researchers hope the technique -- once it is tested more thoroughly and expanded into human trials -- could be useful for women with hair loss, men in the early stages of male pattern baldness, and burn victims who need both skin and follicles. (medindia.net)
  • Researchers have also uncovered an ancient Egyptian human mandible dated to approximately 2800 B.C.E. The mandible, having two perforations just below the root of the first molar, indicates the draining of an abscessed tooth. (newworldencyclopedia.org)
  • This is the only instance in American medicine where doctors and researchers are more interested in the deliberate destruction of a normal, healthy part of the human body, rather than preserving it. (blogspot.jp)
  • A new type of artificial skin which has been developed by a UK-based biotechnology company is more effective than previously-tested skin substitutes, researchers claim. (netdoctor.co.uk)
  • Researchers are also looking at PCL's potential as an implant to deliver medications directly to the eyes and to tumors and as a scaffold for growing human tissue. (docwellnessformula.com)
  • Medical researchers believe that stem cell treatments have the potential to change the face of human disease and alleviate suffering. (statemaster.com)
  • radical a fissure Cialis, researchers, a nitrate uncovered positive include: Sometimes, Development, serious called human placental occur men. (famosa.es)
  • Ever since human embryonic stem cells were first harvested and maintained outside the body in 1998, scientists and surgeons and politicians and patients have conjured up different versions of this dream. (esquire.com)
  • We examined self-renewing human embryonic stem cells (hESCs), which typically exhibit a dispersed distribution of the pluripotency marker NANOG. (jove.com)
  • Alternatively, pluripotent human embryonic stem cells (hESCs) proffer cures for a wide range of neurological disorders by supplying the diversity of human neuronal cell types in the developing CNS for regeneration 1,4-7 . (jove.com)
  • Using their synthetic material, called Silastic , Burke and Yannas continued experimenting and found that artificialskin acts like a framework onto which new skin tissue and blood vessels grow, although these new cells are unable to produce hair follicles or sweat glands normally formed in the dermis. (faqs.org)
  • Play media While most definitions of tissue engineering cover a broad range of applications, in practice the term is closely associated with applications that repair or replace portions of or whole tissues (i.e., bone, cartilage, blood vessels, bladder, skin, muscle etc. (wikipedia.org)
  • They also needed the structure to form without the skin cells related to the immune system or blood vessels, as these cells are why a burn victim rejects a skin transplant. (howstuffworks.com)
  • They are marks made up of excess or abnormal blood vessels in the skin. (bad.org.uk)
  • It is not "just a snip of skin" but a complex organ of muscle, immune cells, bands, nerves, blood vessels etc that are vitally important for protecting the body from viruses/bacteria and sexual function. (blogspot.com)
  • The foreskin contains several feet of blood vessels, including the frenular artery and branches of the dorsal artery. (butterflybirth.com)
  • Such techniques are costly, and have the potential to produce unsatisfactory results or serious complications related to the skin graft. (bionity.com)
  • Scientists from Intercytex say that their prototype, known as ICX-SKN, can be fully and consistently integrated into the human body, compared to other skin graft alternatives which may biodegrade after a few weeks. (netdoctor.co.uk)
  • 2 An artificial joint An artificial blood- vessel graft A neurosurgical shunt Any other implanted foreign body A regular prescription for a blood thinning agent such as warfarin, aspirin, clopidogrel (Plavix ), rivaroxaban, prasugrel or dabigatran A previous or current MRSA infection A high risk of variant- CJD (if you have had a corneal transplant, a neurosurgical dural transplant or injections of human- derived growth hormone). (docplayer.net)
  • A very thin skin graft is used from an appropriate donor site such as the posterior aspect of the thigh. (scielo.org.za)
  • The explants for developing artificial skin for the graft might come from the patient himself to avoid rejection. (expertsmind.com)
  • However, its Cell therapy which also called cellular therapy or effectiveness is often challenged in treating severe burn cytotherapy involves delivering an autologous or allo- patients with limited donor sites for skin graft harvest- genic cellular component into a patient to repair or re- ing. (deepdyve.com)
  • The foreskins of circumcised babies are preferred to those of adult males, since their cells can survive for longer. (naturalnews.com)
  • In an average circumcised adult man, the area of skin that is missing because of penile reduction surgery would, when erect and unfolded, measure approximately three by five inches, or a little smaller than a postcard. (cirp.org)
  • Puberty is the period of human development when a child's body matures into an adult body. (researchautism.org)
  • Seeing so many burn victims during his career, Burke had long been seeking a replacement for human skin that would prevent infection and dehydration. (faqs.org)
  • Clinical signs of infection are redness of the skin around the wound, purulent (pus-containing) drainage, foul odor, and edema. (encyclopedia.com)
  • In a previous study, Haemophilus ducreyi was found in the pustule and dermis of samples obtained at the clinical end point in the human model of infection. (asm.org)
  • To study the pathogenesis of chancroid, we developed a human model of H. ducreyi infection in which volunteers are inoculated on the upper arm with H. ducreyi and observed until a painful pustule forms or disease resolves ( 4 , 25 , 26 ). (asm.org)
  • First, infection is possible for a person with chronic respiratory alkalosis is a potentially poisonous substance has been identii ed in human dysplastic kidneys additional evidence to show that one unit of time. (nationalnewstoday.com)
  • Thus, this study might contribute to a better understanding of human defense systems against fungal infection and the development of urgently needed novel antifungal therapeutics. (pnas.org)
  • The infection may occur under the foreskin. (healthwise.net)
  • The foreskin may also be a pathway of infection for certain diseases. (shermanlegal.com)
  • The ridged bands are situated about halfway down the shaft, when the foreskin is retracted fully. (cirp.org)
  • We've watched before as human foreskin is harvested from infant boys in the United States and sold for use in cosmetics nationally and overseas. (drmomma.org)
  • The continued success of tissue engineering, and the eventual development of true human replacement parts, will grow from the convergence of engineering and basic research advances in tissue, matrix, growth factor, stem cell, and developmental biology, as well as materials science and bio informatics. (wikipedia.org)
  • For her project Ergo Sum Charlotte Jarvis donated blood, skin and urine to the stem cell research laboratory at the University of Leiden. (we-make-money-not-art.com)
  • Apligraf (Organogenesis, Canton, MA) is a bi-layered bioengineered skin substitute and was the first engineered skin US Food and Drug Administration (FDA)-approved to promote the healing of ulcers that have failed standard wound care. (elsevier.com)
  • Optimally, the model would allow for the investigation of the wound pathophysiology and be applicable to skin transplantation. (biomedcentral.com)
  • Artificial skin from newborn skin explants is used to wrap the wound until the patient's skin is cultured and artificial skin is gained for grafting. (expertsmind.com)
  • The aim of this study was to investigate the possibility of fabricating skin substitutes via a bottom-up nanofiber-enabled cell assembly approach and using such substitutes for full-thickness wound repair in nude mice. (nih.gov)
  • This article aims to provide an up-to-date review of the research development and clinical applications of cell therapies in burn wound healing and skin regeneration. (deepdyve.com)
  • decades, cell-based therapies have emerged as popular Globally, severe burns lead to about 180,000 deaths an- choices in conjunction with standard skin grafting tech- nually and millions of patients suffering from non-fatal niques for burn wound healing and regeneration of skin burns experiencing substantial and life-long physical and structure and functions. (deepdyve.com)
  • up-to-date review of the research development and clin- Severe burn wound is characterised by the destruction ical applications of cell therapies in severe burn wound of skin structures, functions and more importantly the healing. (deepdyve.com)
  • Until now, autologous skin grafting remains a Development of cell therapy for burn wound healing standard practice in treating severe burns. (deepdyve.com)
  • Re- various bio-factors to facilitate the angiogenesis and search on skin cell transplantation for wound healing granulation of wound bed for further surgery, they could was first reported by Billingham and Reynolds in 1952 never replace the skin autograft delivering the essential . (deepdyve.com)
  • Why would anyone selectively remove foreskins, not just from real people but from scientific anatomical texts, which I had thought were meant to represent the natural human form? (greenmedinfo.com)
  • Dr John R. Taylor, co-author of two medical anatomical papers about the foreskin, explains the latest research at the Ridged Band website. (cirp.org)
  • Surgical removal of the foreskin. (docplayer.net)
  • Imiquimod Cream is indicated for the topical treatment of biopsy-confirmed, primary superficial basal cell carcinoma (sBCC) in immunocompetent adults, with a maximum tumor diameter of 2.0 cm, located on the trunk (excluding anogenital skin), neck, or extremities (excluding hands and feet), only when surgical methods are medically less appropriate and patient follow-up can be reasonably assured. (nih.gov)
  • 8 In so doing, skin substitutes, in general, not only save lives, as in the case of full-thickness burn wounds, but also improve the quality of life of those affected. (scielo.org.za)
  • Mahjour[author] AND Rapid creation of skin substitutes from hu. (nih.gov)
  • Creation of functional skin substitutes within a clinically acceptable time window is essential for timely repair and management of large wounds such as extensive burns. (nih.gov)
  • As the new skin grows, the cowhide and shark substances from the artificial skin are broken down and absorbed by the body. (faqs.org)
  • Doctors could cut skin from another part of the patient's body, stretch it and perform a transplant , but this painful procedure wasn't an option for patients who didn't have enough skin left to use. (howstuffworks.com)
  • At examination, it was possible to strip most males to the waist so that the skin of the upper part of the body was seen, but the women could not be so examined. (openthemagazine.com)
  • It is on the human body for a purpose - it serves many important developmental, immunological, and sexual functions . (drmomma.org)
  • It's easy to laugh off an obvious gag on a site as a means by which to ignore the rest so I thought I would create a list here of why foreskins are useful, necessary body parts and not just a useless flap of skin. (bubhub.com.au)
  • Among them are certain types of free-form optoelectronic devices, which can be attached close to the human body based on their conformal design. (nature.com)
  • It is expected that multiple free-form optoelectronic devices, in close contact with the human body, will be conveniently and simultaneously used for various functions. (nature.com)
  • Such conformable OLEDs can be more effective in terms of therapeutic effects because they can efficiently transmit light to the skin since they are located close to the human body. (nature.com)
  • The body part that is at the heart of this issue is a very small piece of flesh - a circumcised foreskin. (blogspot.com)
  • Just as breast-feeding infants is making a huge resurgence as more and more people try to reduce their carbon footprint on the earth, more and more people are now looking unfavorably upon using any part of a human body in a cosmetic product no matter how small that contribution may be. (blogspot.com)
  • They develop in the bone marrow then spread in the blood all over the body, including the skin. (bad.org.uk)
  • It reduces skin inflammation by blocking the activity of chemical molecules called cytokines (interleukin 12 and 23) in the body that trigger inflammation in psoriasis. (bad.org.uk)
  • The inner foreskin layer is not just "skin," but mucocutaneous tissue of a unique type found nowhere else on the body. (cirp.org)
  • Currently, treatment for serious burns and major wounds uses a section of skin from another part of a patient's body, which is grafted onto the affected area. (netdoctor.co.uk)
  • If you're going to take care of your body and overall appearance why neglect your skin? (undereyecream.org)
  • However, it is largely unknown how and why human body surfaces resist fungal infections. (pnas.org)
  • We identified the common epithelial protein, psoriasin (S100A7), in its disulphide-reduced form (redS100A7) as the principal antifungal factor of human body surfaces. (pnas.org)
  • In artificial pancreas, external insulin (not produced by body) is automatically injected though a pump into the body. (ndtv.com)
  • The first synthetic skin was invented by John F. Burke, chief of Trauma Services at MassachusettsGeneral Hospital, and Ioannis V. Yannas, chemistry professor at MassachusettsInstitute of Technology. (faqs.org)
  • The foreskin usually starts to develop in the 3rd month during the gestation period and the ventral part of the foreskin will get closed in the 5th month (of gestation period). (news-medical.net)
  • Doctors and ethicists are embroiled in a dispute with Health Minister Aaron Motsoaledi over fears that babies' foreskins will be sold illicitly to the global cosmetics industry. (timeslive.co.za)
  • One such fact that many parents are not aware of, is that the foreskins of babies who are circumcised are sometimes sold off to Big Pharma developers for the research and growth of vaccines. (naturalnews.com)
  • These harvested foreskins belong to babies and toddlers who are not yet able to consent to the organ's amputation from their own bodies. (drmomma.org)
  • We also think that this study is an important step toward the goal of creating a replacement skin that contains hair follicles for use with, for example, burn patients," he said. (medindia.net)
  • The foreskin contains branches of the dorsal nerve and between 10,000 and 20,000 specialized erotogenic nerve endings of several types, which are capable of sensing slight motion and stretch, subtle changes in temperature, and fine gradations in texture. (butterflybirth.com)
  • Angio-oedema usually affects soft areas of skin, such as the eyelids, lips or inside the mouth but may occur anywhere. (bad.org.uk)
  • Intense local inflammatory reactions can occur (e.g., skin weeping, erosion). (nih.gov)
  • H. ducreyi enters the host through microabrasions that occur during intercourse and primarily remains localized in the skin. (asm.org)
  • All jokes aside, all funny tricks aside, the male foreskin is an awesome thing. (bubhub.com.au)
  • How appropriate that in this modern age of corporate "philanthropy" and mass human psychopathy, the male physiological conduit for ecstatic emotional connection finds a new after-life as a zombie in the economic processes of the state, servicing the female emotional needs engendered by its absence in the male. (thoughtcrimeradio.net)
  • The Male catheterization trainer has a removable foreskin. (buyamag.com)
  • 8. The composition of claim 4 wherein the polypeptide is selected from the group consisting of human growth hormone, Factor VIII, Factor IX, erythropoietin, and insulin. (google.es)
  • Insulin-like growth factor binding protein-related protein 1 (IGFBP-rP1) has potential tumour-suppressive activity in human lung cancer," J. Pathol. (freepatentsonline.com)