Pterygium: An abnormal triangular fold of membrane in the interpalpebral fissure, extending from the conjunctiva to the cornea, being immovably united to the cornea at its apex, firmly attached to the sclera throughout its middle portion, and merged with the conjunctiva at its base. (Dorland, 27th ed)Conjunctiva: The mucous membrane that covers the posterior surface of the eyelids and the anterior pericorneal surface of the eyeball.ThyminePyrimidine Dimers: Dimers found in DNA chains damaged by ULTRAVIOLET RAYS. They consist of two adjacent PYRIMIDINE NUCLEOTIDES, usually THYMINE nucleotides, in which the pyrimidine residues are covalently joined by a cyclobutane ring. These dimers block DNA REPLICATION.DNA Repair: The reconstruction of a continuous two-stranded DNA molecule without mismatch from a molecule which contained damaged regions. The major repair mechanisms are excision repair, in which defective regions in one strand are excised and resynthesized using the complementary base pairing information in the intact strand; photoreactivation repair, in which the lethal and mutagenic effects of ultraviolet light are eliminated; and post-replication repair, in which the primary lesions are not repaired, but the gaps in one daughter duplex are filled in by incorporation of portions of the other (undamaged) daughter duplex. Excision repair and post-replication repair are sometimes referred to as "dark repair" because they do not require light.DNA Damage: Injuries to DNA that introduce deviations from its normal, intact structure and which may, if left unrepaired, result in a MUTATION or a block of DNA REPLICATION. These deviations may be caused by physical or chemical agents and occur by natural or unnatural, introduced circumstances. They include the introduction of illegitimate bases during replication or by deamination or other modification of bases; the loss of a base from the DNA backbone leaving an abasic site; single-strand breaks; double strand breaks; and intrastrand (PYRIMIDINE DIMERS) or interstrand crosslinking. Damage can often be repaired (DNA REPAIR). If the damage is extensive, it can induce APOPTOSIS.Corneal Transplantation: Partial or total replacement of the CORNEA from one human or animal to another.ArchivesBiological Science Disciplines: All of the divisions of the natural sciences dealing with the various aspects of the phenomena of life and vital processes. The concept includes anatomy and physiology, biochemistry and biophysics, and the biology of animals, plants, and microorganisms. It should be differentiated from BIOLOGY, one of its subdivisions, concerned specifically with the origin and life processes of living organisms.Periodicals as Topic: A publication issued at stated, more or less regular, intervals.PhenylbutyratesPubMed: A bibliographic database that includes MEDLINE as its primary subset. It is produced by the National Center for Biotechnology Information (NCBI), part of the NATIONAL LIBRARY OF MEDICINE. PubMed, which is searchable through NLM's Web site, also includes access to additional citations to selected life sciences journals not in MEDLINE, and links to other resources such as the full-text of articles at participating publishers' Web sites, NCBI's molecular biology databases, and PubMed Central.Epithelium, Corneal: Stratified squamous epithelium that covers the outer surface of the CORNEA. It is smooth and contains many free nerve endings.Cornea: The transparent anterior portion of the fibrous coat of the eye consisting of five layers: stratified squamous CORNEAL EPITHELIUM; BOWMAN MEMBRANE; CORNEAL STROMA; DESCEMET MEMBRANE; and mesenchymal CORNEAL ENDOTHELIUM. It serves as the first refracting medium of the eye. It is structurally continuous with the SCLERA, avascular, receiving its nourishment by permeation through spaces between the lamellae, and is innervated by the ophthalmic division of the TRIGEMINAL NERVE via the ciliary nerves and those of the surrounding conjunctiva which together form plexuses. (Cline et al., Dictionary of Visual Science, 4th ed)Tears: The fluid secreted by the lacrimal glands. This fluid moistens the CONJUNCTIVA and CORNEA.Phospholipase D: An enzyme found mostly in plant tissue. It hydrolyzes glycerophosphatidates with the formation of a phosphatidic acid and a nitrogenous base such as choline. This enzyme also catalyzes transphosphatidylation reactions. EC 3.1.4.4.Conjunctival DiseasesLower Extremity Deformities, Congenital: Congenital structural abnormalities of the LOWER EXTREMITY.Cleft Lip: Congenital defect in the upper lip where the maxillary prominence fails to merge with the merged medial nasal prominences. It is thought to be caused by faulty migration of the mesoderm in the head region.Cleft Palate: Congenital fissure of the soft and/or hard palate, due to faulty fusion.Lip: Either of the two fleshy, full-blooded margins of the mouth.Syndactyly: A congenital anomaly of the hand or foot, marked by the webbing between adjacent fingers or toes. Syndactylies are classified as complete or incomplete by the degree of joining. Syndactylies can also be simple or complex. Simple syndactyly indicates joining of only skin or soft tissue; complex syndactyly marks joining of bony elements.Urogenital Abnormalities: Congenital structural abnormalities of the UROGENITAL SYSTEM in either the male or the female.Receptors, Nicotinic: One of the two major classes of cholinergic receptors. Nicotinic receptors were originally distinguished by their preference for NICOTINE over MUSCARINE. They are generally divided into muscle-type and neuronal-type (previously ganglionic) based on pharmacology, and subunit composition of the receptors.Acetylcholine: A neurotransmitter found at neuromuscular junctions, autonomic ganglia, parasympathetic effector junctions, a subset of sympathetic effector junctions, and at many sites in the central nervous system.Protein Precursorsalpha7 Nicotinic Acetylcholine Receptor: A member of the NICOTINIC ACETYLCHOLINE RECEPTOR subfamily of the LIGAND-GATED ION CHANNEL family. It consists entirely of pentameric a7 subunits expressed in the CNS, autonomic nervous system, vascular system, lymphocytes and spleen.Receptors, Cholinergic: Cell surface proteins that bind acetylcholine with high affinity and trigger intracellular changes influencing the behavior of cells. Cholinergic receptors are divided into two major classes, muscarinic and nicotinic, based originally on their affinity for nicotine and muscarine. Each group is further subdivided based on pharmacology, location, mode of action, and/or molecular biology.Ion Channels: Gated, ion-selective glycoproteins that traverse membranes. The stimulus for ION CHANNEL GATING can be due to a variety of stimuli such as LIGANDS, a TRANSMEMBRANE POTENTIAL DIFFERENCE, mechanical deformation or through INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS.Reflex, Righting: The instinctive tendency (or ability) to assume a normal position of the body in space when it has been displaced.Fibrin Tissue Adhesive: An autologous or commercial tissue adhesive containing FIBRINOGEN and THROMBIN. The commercial product is a two component system from human plasma that contains more than fibrinogen and thrombin. The first component contains highly concentrated fibrinogen, FACTOR VIII, fibronectin, and traces of other plasma proteins. The second component contains thrombin, calcium chloride, and antifibrinolytic agents such as APROTININ. Mixing of the two components promotes BLOOD CLOTTING and the formation and cross-linking of fibrin. The tissue adhesive is used for tissue sealing, HEMOSTASIS, and WOUND HEALING.Autografts: Transplant comprised of an individual's own tissue, transferred from one part of the body to another.Los AngelesTissue Adhesives: Substances used to cause adherence of tissue to tissue or tissue to non-tissue surfaces, as for prostheses.Contact Lenses: Lenses designed to be worn on the front surface of the eyeball. (UMDNS, 1999)Astigmatism: Unequal curvature of the refractive surfaces of the eye. Thus a point source of light cannot be brought to a point focus on the retina but is spread over a more or less diffuse area. This results from the radius of curvature in one plane being longer or shorter than the radius at right angles to it. (Dorland, 27th ed)Corneal Topography: The measurement of curvature and shape of the anterior surface of the cornea using techniques such as keratometry, keratoscopy, photokeratoscopy, profile photography, computer-assisted image processing and videokeratography. This measurement is often applied in the fitting of contact lenses and in diagnosing corneal diseases or corneal changes including keratoconus, which occur after keratotomy and keratoplasty.Keratoconus: A noninflammatory, usually bilateral protrusion of the cornea, the apex being displaced downward and nasally. It occurs most commonly in females at about puberty. The cause is unknown but hereditary factors may play a role. The -conus refers to the cone shape of the corneal protrusion. (From Dorland, 27th ed)WingOphthalmic Solutions: Sterile solutions that are intended for instillation into the eye. It does not include solutions for cleaning eyeglasses or CONTACT LENS SOLUTIONS.Ointments: Semisolid preparations used topically for protective emollient effects or as a vehicle for local administration of medications. Ointment bases are various mixtures of fats, waxes, animal and plant oils and solid and liquid hydrocarbons.Blepharitis: Inflammation of the eyelids.Amnion: The innermost membranous sac that surrounds and protects the developing embryo which is bathed in the AMNIOTIC FLUID. Amnion cells are secretory EPITHELIAL CELLS and contribute to the amniotic fluid.Biological Dressings: Human or animal tissue used as temporary wound coverings.Patents as Topic: Exclusive legal rights or privileges applied to inventions, plants, etc.Membrane Lipids: Lipids, predominantly phospholipids, cholesterol and small amounts of glycolipids found in membranes including cellular and intracellular membranes. These lipids may be arranged in bilayers in the membranes with integral proteins between the layers and peripheral proteins attached to the outside. Membrane lipids are required for active transport, several enzymatic activities and membrane formation.Limbus Corneae: An annular transitional zone, approximately 1 mm wide, between the cornea and the bulbar conjunctiva and sclera. It is highly vascular and is involved in the metabolism of the cornea. It is ophthalmologically significant in that it appears on the outer surface of the eyeball as a slight furrow, marking the line between the clear cornea and the sclera. (Dictionary of Visual Science, 3d ed)Corneal Diseases: Diseases of the cornea.Burns, ChemicalAuthorship: The profession of writing. Also the identity of the writer as the creator of a literary production.Knowledge Bases: Collections of facts, assumptions, beliefs, and heuristics that are used in combination with databases to achieve desired results, such as a diagnosis, an interpretation, or a solution to a problem (From McGraw Hill Dictionary of Scientific and Technical Terms, 6th ed).Tryptases: A family of neutral serine proteases with TRYPSIN-like activity. Tryptases are primarily found in the SECRETORY GRANULES of MAST CELLS and are released during mast cell degranulation.Editorial Policies: The guidelines and policy statements set forth by the editor(s) or editorial board of a publication.Scientific Misconduct: Intentional falsification of scientific data by presentation of fraudulent or incomplete or uncorroborated findings as scientific fact.Publishing: "The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.Chymases: A family of neutral serine proteases with CHYMOTRYPSIN-like activity. Chymases are primarily found in the SECRETORY GRANULES of MAST CELLS and are released during mast cell degranulation.
Untersuchungen über den Bau der Hornhaut und des Flügelfelles (Studies on the construction of the cornea and pterygium), Gießen ... Zur Gewebelehre der Menschenhornhaut (Lessons on human corneal tissue) in: Virchow's Archiv, 1856, Band X, S. 506f. Lehrbuch ... Experimentalstudien über die Pathologie des Flügelfelles (Experimental studies on the pathology of pterygium), 1866. Vorträge ... Textbook of general pathological-anatomy on the tissues of humans), Gießen 1860. ...
"Human PubMed Reference:". "Mouse PubMed Reference:". "Entrez Gene: CHRNG cholinergic receptor, nicotinic, gamma". Human CHRNG ... cause lethal and Escobar variants of multiple pterygium syndrome". Am. J. Hum. Genet. 79 (2): 390-5. doi:10.1086/506256. PMC ... Acetylcholine receptor subunit gamma is a protein that in humans is encoded by the CHRNG gene. For background information on ... 2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci ...
... human gene location in the UCSC Genome Browser. IRF6 human gene details in the UCSC Genome Browser. This article ... Gorlin RJ, Sedano HO, Cervenka J (February 1968). "Popliteal pterygium syndrome . A syndrome comprising cleft lip-palate, ... Interferon regulatory factor 6 also known as IRF6 is a protein that in humans is encoded by the IRF6 gene. This gene encodes a ... GeneReview/NIH/UW entry on IRF6-Related Disorders IRF6 protein, human at the US National Library of Medicine Medical Subject ...
Common symptoms in humans and other animals include red or reddish skin that is hot to the touch, pain, general fatigue, and ... UV light has been implicated in the development of age-related macular degeneration, pterygium and cataract. Concentrated ... "The Surgeon General's Call to Action to Prevent Skin Cancer" (PDF). U.S. Department of Health and Human Services. 2014. p. 20. ... Solomon, AS (June 2006). "Pterygium". British Journal of Ophthalmology. 90 (6): 665-666. doi:10.1136/bjo.2006.091413. PMC ...
... deafness Oligodendroglioma Parkinson disease Pheochromocytoma porphyria porphyria cutanea tarda popliteal pterygium syndrome ... Chromosome 1 is the designation for the largest human chromosome. Humans have two copies of chromosome 1, as they do with all ... See also: Category:Genes on human chromosome 1. The following is a partial list of genes on human chromosome 1. For complete ... International Standing Committee on Human Cytogenetic Nomenclature (2013). ISCN 2013: An International System for Human ...
FactorBook AP-2alpha TFAP2A human gene location in the UCSC Genome Browser. TFAP2A human gene details in the UCSC Genome ... "Mutations in IRF6 cause Van der Woude and popliteal pterygium syndromes". Nature Genetics. 32 (2): 285-9. doi:10.1038/ng985. ... Human sequence as reference and searched for multispecies conserved sequences (MCSs). Regions contained in introns 5' and 3' ... Bragança J, Swingler T, Marques FI, Jones T, Eloranta JJ, Hurst HC, Shioda T, Bhattacharya S (Mar 2002). "Human CREB-binding ...
Amniotic membrane transplantation is tissue that is acquired from the innermost layer of the human placenta and has been used ... In addition, pterygia are twice as likely to occur in men than women. Pterygium in the conjunctiva is characterized by ... It has an advancing portion called the head of the pterygium, which is connected to the main body of the pterygium by the neck ... The pterygium is composed of several segments: Fuchs' Patches (minute gray blemishes that disperse near the pterygium head) ...
It is made up of fibrinogen (lyophilised pooled human concentrate) and thrombin (bovine, which is reconstituted with calcium ... It is also employed in "no sutures" corneal transplantation, pterygium excision with amniotic membrane or conjunctival ... "Fibrin glue from stored human plasma. An inexpensive and efficient method for local blood bank preparation". The American ...
... cycle Hodgkin-Huxley model Homeoviscous adaptation Homologous desensitization Hopanoids Howard Berg Hugh Herr Human leg Human ... Prediction Protein targeting Protein-lipid interaction Protomer Protoplast Pseudopeptidoglycan Pseudopodia Pterygium Q-type ... Osvaldo Magnasco Marche a petit pas Mario Ageno Martin Gruebele Maurice Wilkins Max Delbrück Max Perutz Mechanics of human ...
In humans, fetal cleft lip and other congenital abnormalities have also been linked to maternal hypoxia, as caused by e.g. ... Malpuech facial clefting syndrome Hearing loss with craniofacial syndromes Popliteal pterygium syndrome Treacher Collins ... Boklage, Charles E. (2010). How new humans are made cells and embryos, twins and chimeras, left and right, mind/selfsoul, sex, ... a major human birth defect". Acta Histochem. 109 (1): 1-14. doi:10.1016/j.acthis.2006.05.009. PMID 16962647. Dudas M, Li WY, ...
ISBN 0-8014-4176-5. Leroi, Armand Marie (2003). Mutants: On Genetic Variety and the Human Body. Penguin Books. ISBN 0-670-03110 ... radial hypoplasia with pterygium to give the impression of wings, and caudal regression, the latter of which may have been ... and with one leg hairy and cloven-hoofed while the other leg's midsection grew a human eye. On March 11, the apothecary Luca ...
... (HB-EGF) is a member of the EGF family of proteins that in humans is encoded by the ... "Proliferative effects of heparin-binding epidermal growth factor-like growth factor on pterygium epithelial cells and ... For numerous cell types such as breast and ovarian tumor cells, human epithelial cells and keratinocytes HB-EGF is a potent ... First identified in the conditioned media of human macrophage-like cells, HB-EGF is an 87-amino acid glycoprotein that displays ...
It is sometimes done as part of a spiritual or religious practice.[1] The human eye is very sensitive, and prolonged exposure ... to direct sunlight can lead to solar retinopathy, pterygium,[2] cataracts,[3] and often blindness.[4][5][6] Studies have shown ... "Pterygium". British Journal of Ophthalmology. 90 (6): 665-6. doi:10.1136/bjo.2006.091413. PMC 1860212. PMID 16714259 ...
... pterygia, short body height, and progressive kyphoscoliosis. Individuals encounter restricted mobility and pulmonary function. ... "Mutations in FKBP10 cause both Bruck syndrome and isolated osteogenesis imperfecta in humans". American Journal of Medical ...
... is the designation for the largest human chromosome. Humans have two copies of chromosome 1, as they do with all ... See also: Category:Genes on human chromosome 1.. The following is a partial list of genes on human chromosome 1. For complete ... International Standing Committee on Human Cytogenetic Nomenclature (2013). ISCN 2013: An International System for Human ... G-bands of human chromosome 1 in resolution 850 bphs[19]. Chr. Arm[20]. Band[21]. ISCN. start[22]. ISCN. stop[22]. Basepair. ...
Eye, human Encyclopædia Britannica *^ a b PAVLOU AT; WOLFF HG (1959-07-01). "THe bulbar conjunctival vessels in occlusion of ... MacKenzie, L. E.; Choudhary, T. R.; McNaught, A. I.; Harvey, A. R. (2016-06-15). "In vivo oximetry of human bulbar conjunctival ... Image of a human eye showing the blood vessels of the bulbar conjunctiva ... Red Sclera as a Uniquely Human Cue of Emotion". Ethology. 119 (11): 993-998. doi:10.1111/eth.12144. ISSN 1439-0310.. ...
Psoriatic nails Pterygium inversum unguis (pterygium inversus unguis, ventral pterygium) Pterygium unguis (dorsal pterygium) ... Herpetic sycosis Herpetic whitlow HIV-associated pruritus Human monkeypox Human T-lymphotropic virus 1 infection Human tanapox ... Human granulocytotropic anaplasmosis Human monocytotropic ehrlichiosis Impetigo contagiosa Japanese spotted fever Leptospirosis ... Conditions of the human integumentary system constitute a broad spectrum of diseases, also known as dermatoses, as well as many ...
... the binding of human vascular epithelial cells to human monocytes; d) DNA synthesis and mitogenesis in the immortalized human ... "Dysregulated heme oxygenase-ferritin system in pterygium pathogenesis". Cornea. 32 (9): 1276-82. doi:10.1097/ICO. ... human umbilical vein endothelial cells (HUVEC), human brain microvascular endothelial cells (HBMEC), and human pulmonary aortic ... GPR31 mRNA is expressed at low levels in several human cell lines including K562 cells (human myelogenous leukemia cell line), ...
Gregory SG, Barlow KF, McLay KE, et al. (May 2006). "The DNA sequence and biological annotation of human chromosome 1". Nature ... 2] It represents about 8% of the total DNA in human cells.[3] ... popliteal pterygium syndrome. *prostate cancer. *Stickler ... Ayon sa http://www.ornl.gov/sci/techresources/Human_Genome/posters/chromosome/chromo01.shtml, ang kromosomang 1 ay naglalaman ...
De-escalation treatment protocols for human papillomavirus-associated oropharyngeal squamous cell carcinoma PMID 24532092 https ... Done Fibrin glue versus sutures for conjunctival autografting in primary pterygium surgery PMID 27911983 https://doi.org/ ...
The typical human retina contains two kinds of light cells: the rod cells (active in low light) and the cone cells (active in ... It is most commonly inherited from mutations on the X chromosome, but the mapping of the human genome has shown there are many ... In 2012, at a TED Conference, Harbisson explained how he could now perceive colors outside the ability of human vision.[73] ... Harrison, G.A.; Tanner, J.M.; Pilbeam, D.R.; Baker, P.T. (1988). Human Biology. Oxford: Oxford University Press. pp. 183-187, ...
The typical human retina contains two kinds of light cells: the rod cells (active in low light) and the cone cells (active in ... "Human Vision and Color Perception". Florida State University. Archived from the original on 2007-08-27. Retrieved 2007-04-05.. ... Kaiser PK, Boynton RM (1996). Human color vision. Washington, DC: Optical Society of America. ISBN 978-1-55752-461-4. . OCLC ... Harrison G, Tanner J, Pilbeam D, Baker P (1988). Human Biology. Oxford: Oxford University Press. pp. 183-187, 287-290. ISBN 978 ...
Systemic associations in humans[edit]. In humans, a number of systemic conditions are associated with ectopia lentis:[12] ... Although observed in humans and cats, ectopia lentis is most commonly seen in dogs. Ciliary zonules normally hold the lens in ...
Ultraviolet rays are invisible to most humans. The lens of the human eye blocks most radiation in the wavelength range of 300- ... Exposure to these can cause "welder's flash" or "arc eye" (photokeratitis) and can lead to cataracts, pterygium and pinguecula ... The lower wavelength limit of human vision is conventionally taken as 400 nm, so ultraviolet rays are invisible to humans, ... including humans (specifically, UVB).[3] The UV spectrum thus has effects both beneficial and harmful to human health. ...
... rays are invisible to most humans. The lens of the human eye blocks most radiation in the wavelength range of 300- ... Exposure to these can cause "welder's flash" or "arc eye" (photokeratitis) and can lead to cataracts, pterygium and pinguecula ... The lower wavelength limit of human vision is conventionally taken as 400 nm, so ultraviolet rays are invisible to humans, ... "Detection of Semen (Human and Boar) and Saliva on Fabrics by a Very High Powered UV-/VIS-Light Source" (PDF). Archived from the ...
U.S. Department of Health & Human Services.. *^ a b c Kaplan YC, Ozsarfati J, Etwel F, Nickel C, Nulman I, Koren G (November ... Pterygium inversum unguis. *Pterygium unguis. *Purpura of the nail bed. *Racquet nail ... U.S. Department of Health and Human Services, Office of Public Health and Science, Office on Women's Health. July 2009. ... Milk and Milk Products in Human Nutrition. Nestle Nutrition Workshop Series. Paediatric Programme. Nestlé Nutrition Institute ...
... of human pterygium. Several mechanisms for blood and lymphatic vessel development in human pterygium have been proposed, ... Conclusions: Thymine dimers in human pterygium and its recurrences suggest that DNA damage is involved not only in pterygium ... in the recurrent pterygium. Human pterygium fibroblasts are the most studied and controversial cells from this eye lesion [23- ... human pterygium compared with the stromal components. The p53 positivity observed in primary and recurrent pterygium had a ...
Tissue factor expression in human pterygium.. [Ryo Ando, Satoru Kase, Tsutomu Ohashi, Zhenyu Dong, Junichi Fukuhara, Atsuhiro ... Eight pterygia and three normal bulbar conjunctivas, surgically removed, were used in this study. Formalin-fixed, paraffin- ... A pterygium shows tumor-like characteristics, such as proliferation, invasion, and epithelial-mesenchymal transition (EMT). ... In this study, we analyzed the expression and immunolocalization of TF in pterygial and normal conjunctival tissues of humans. ...
Human pterygium fibroblasts obtained from patient pterygium tissue were treated with butyrate or phenylbutyrate for 48h. ... Suppression of fibrosis in human pterygium fibroblasts by butyrate and phenylbutyrate. Yuka Koga,1 Noriaki Maeshige,1,2 Hiroto ... However, these effects of butyrate in human pterygium fibroblasts (HPFs) have not been investigated. Because butyrate has a ... To evaluate the antifibrogenic effects of butyrate or phenylbutyrate, a chemical derivative of butyrate, in human pterygium ...
L. M. Tong, J. Li, D. T. H. Tan, R. W. Beuerman; Phospholipase D in the Human Ocular Surface and Pterygium. Invest. Ophthalmol ... Phospholipase D in the Human Ocular Surface and Pterygium You will receive an email whenever this article is corrected, updated ... Purpose: : Pterygium is an ocular surface disease of unknown etiology characterized by growth of fibrovascular tissue from ... We aimed to investigate the presence of PLD subtypes in native ocular surface tissue and pterygium. ...
The morphology of human pterygium fibroblasts (HPFs). HPFs were cultured and characterized from explants of fresh pterygium ... Efficacy of curcumin in inducing apoptosis and inhibiting the expression of VEGF in human pterygium fibroblasts. *Authors: * ... Zhang M, Bian F, Wen C and Hao N: Inhibitory effect of curcumin on proliferation of human pterygium fibroblasts. J Huazhong ... The purpose of the present study was to investigate the inhibitory effects of curcumin on human pterygium fibroblasts (HPFs) in ...
Methods: Profibrotic activation was induced by TGF-β1 in primary cultured human pterygium fibroblasts and the effect of ... We thus aimed to determine the antifibrotic properties of the PPAR-γ ligand rosiglitazone in cultured primary human pterygium ... A PPAR-Gamma Agonist Rosiglitazone Suppresses Fibrotic Response in Human Pterygium Fibroblasts by Modulating the p38 MAPK ... A PPAR-Gamma Agonist Rosiglitazone Suppresses Fibrotic Response in Human Pterygium Fibroblasts by Modulating the p38 MAPK ...
Results: The adult rodent and human eye as well as pterygium, contain a population of cells expressing Hes3. In the human eye, ... Materials and methods: Adult mouse and human corneoscleral junction and conjunctiva, as well as human pterygium were prepared ... Expression of the transcription factor Hes3 in the mouse and human ocular surface, and in pterygium ... Expression of the transcription factor Hes3 in the mouse and human ocular surface, and in pterygium. International Journal of ...
Helping you find trustworthy answers on Pterygium , Latest evidence made easy ... Find all the evidence you need on Pterygium via the Trip Database. ... on primary human pterygium fibroblasts (HPFs) and primary human conjunctival fibroblasts (HConFs), as well as to explore the ... 3. Pterygium Pterygium Pterygium submit The College submit Youre here: Pterygium Pterygium The CMGs are guidelines on the ...
Human primary pterygium or normal Tenons capsule tissues were obtained from patients with primary pterygium following surgical ... p-eIF2α and ATF6 were all increased in the human primary pterygium tissues when compared with the normal control tissues. ,i, ... and also suggests a potential mechanism of ER stress-induced inflammation in the human primary pterygium tissues. ... in this study suggest that the three unfolded protein response pathways are all activated in the human primary pterygium ...
Several researchers believe that pterygium is UV-related and that abnormal expression of p53 protein and infection with human ... Pterygium is a disease of unknown origin and pathogenesis that can be vision threatening. ... papillomavirus (HPV) are risk factors for pterygium, but their experiments have been inconclusive. We investigated its relation ... TP53 gene expression, codon 72 polymorphism and human papillomavirus DNA associated with pterygium. * F.W. Rodrigues ...
Multiple pterygium syndrome. MedlinePlus Genetics provides information about Multiple pterygium syndrome. More About This ... U.S. National Library of Medicine 8600 Rockville Pike, Bethesda, MD 20894 U.S. Department of Health and Human Services National ...
We hypothesize that the areas of fluorescence represent areas of cellular activity within the pterygium. The patterns of ... fluorescence may be useful to further understand of pterygium growth and pathogenesis. ... we describe patterns of fluorescence in established pterygia by UVFP. ... Of the 20 pterygia, six (30%) of 20 demonstrated fluorescence at the leading edge of the pterygium, seven (35%) of 20 ...
p53 inhibition by MDM2 in human pterygium.. To confirm that mouse double minute 2 (MDM2) could inhibit p53 activity in human ... The Evolving Story of Pterygium.. Pterygium is a fibrovascular subepithelial growth of degenerative tissue over the limbus. It ... Pterygium. An abnormal triangular fold of membrane in the interpalpebral fissure, extending from the conjunctiva to the cornea ... 1. CBT-001 administered three times daily (TID) for 4 weeks has an acceptable safety profile when used in pterygium patients 2 ...
A mathematical approach to human pterygium shape Pajic B, Vastardis I, Rajkovic P, Pajic-Eggspuehler B, Aebersold DM, Cvejic Z ... The measurement repeatability using different partition methods of intraretinal tomographic thickness maps in healthy human ... The use of dry amniotic membrane in pterygium surgery Noureddin GS, Yeung SN ... assessment of optical versus electromagnetic modes and role of dynamic reference frame location using navigation-enabled human ...
Center for Craniofacial and Dental Genetics, Department of Oral Biology, School of Dental Medicine, Department of Human ... Van der Woude and popliteal pterygium syndromes are caused by mutations in IRF6, but phenotypic variability within and among ... Search for genetic modifiers of IRF6 and genotype-phenotype correlations in Van der Woude and popliteal pterygium syndromes. ... We identified an association between mutations in the DNA-binding domain of IRF6 and limb defects (including pterygia). ...
... with primary pterygia were treated with excision, with or without additional therapy, and were followed up for three to eight ... Postoperative instillation of low-dose mitomycin C in the treatment of primary pterygium Am J Ophthalmol. 1988 Dec 15;106(6): ... Eighty patients (99 eyes) with primary pterygia were treated with excision, with or without additional therapy, and were ... to be effective and safe in the treatment of primary pterygium. ... Humans * Mitomycin * Mitomycins / administration & dosage* * ...
human adenoviruses role in ophthalmic pterygium formation.. Kelishadi M, Kelishadi M, Moradi A, Javid N, Bazouri M, Tabarraei A ... Evaluation of a Probe-Based PCR-ELISA System for Simultaneous Semi Quantitative Detection and Genotyping of Human ... Oral poliovirus vaccine-induced programmed cell death involves both intrinsic and extrinsic pathways in human colorectal cancer ... Study of the mechanisms of crocetin-induced differentiation and apoptosis in human acute promyelocytic leukemia cells. ...
To investigate Human Beta Defensins (HBD) and Cathelicidin expressions in patients with pterygium. Setting: Istanbul Medeniyet ... An investigation of human beta defensins and cathelicidin expression in patients with pterygium. Poster Details. First Author: ... We found increased HBD-2 expression in pterygium specimens compared to controls. The HBD-2 expression that might be stimulated ... In this retrospective consecutive case series, 26 pterygium specimens and 15 normal conjunctival specimens of 15 control ...
Lethal Multiple Pterygium Syndrome (LMPS) approved 253290. Leukaemia, acute myeloid, related to GATA2 mutation approved 601626 ...
In lethal multiple pterygium syndrome there is intrauterine growth retardation, multiple pterygia, and flexion contractures ... List of human entries with polymorphisms or disease mutations *Human polymorphisms and disease mutations. Index of human ... Human chromosome 2: entries, gene names and cross-references to MIM *Human entries with polymorphisms or disease mutations. ... Homo sapiens (Human). ,p>This subsection of the Names and taxonomy section shows the unique identifier assigned by the ,span ...
Lethal popliteal pterygium syndrome (OMIM 263650) This is also known as Bartsocas-Papas syndrome and is an autosomal recessive ... Maria Descartes, MD Professor, Department of Human Genetics and Department of Pediatrics, University of Alabama at Birmingham ... An infant with a lethal type of multiple pterygium syndrome. Note multiple joint contractures with marked pterygia and a cystic ... Lethal popliteal pterygium syndrome (OMIM 263650) This is also known as Bartsocas-Papas syndrome and is an autosomal recessive ...
Human pterygium. Unnormalized (nav). eye. uncharacterized histology. uncharacterized preparation. non-normalized. eye, non- ... normalized, adult, EST, plasmid vector, directionally cloned, pterygium. Human fetal heart, Lambda ZAP Express. heart. normal. ... Human bone marrow stromal cells. bone marrow. normal. bulk. non-normalized. bone marrow, normal, non-normalized, bulk, EST, ... Human Fat Cell 5-Stretch Plus cDNA Library. adipose tissue. normal. bulk. uncharacterized treatment. normal, bulk, EST, ...
Human pterygium. Unnormalized (nav). eye. uncharacterized histology. uncharacterized preparation. non-normalized. eye, non- ... Human bone marrow stromal cells. bone marrow. normal. bulk. non-normalized. bone marrow, normal, non-normalized, bulk, EST, ... Human fetal heart, Lambda ZAP Express. heart. normal. bulk. non-normalized. heart, normal, non-normalized, bulk, EST, first ... Human colon mucosa. colon. normal. bulk. non-normalized. epithelium, normal, non-normalized, colon, bulk, adult, EST, male. ...
There are several different types of surgery for pterygium, including those that involve leaving the eye bare where the growth ... Tissue adhesive used in pterygium surgery is made from parts of human blood to help it clot. The clotting proteins in the ... Pterygium often does not encroach on the cornea, making it harmless, but in some cases surgery for pterygium removal is ... A pterygium is a growth on the outside of the eye that can expand over the cornea, obstructing vision and light transmission to ...
Pyroptosis in pterygium pathogenesis Biosci Rep (May, 2018). Dexmedetomidine exerts dual effects on human annulus fibrosus ...
  • Methods A matched-cohort study, using linked health administrative data sets to identify all hospital-treated pterygium in Western Australia (WA) between 1979 and 2014. (bmj.com)
  • Methods: Twenty primary nasal pterygia were studied by indirect routine immunohistochemistry using 13 different primary antibodies against 8 ECMs (five collagens, fibronectin, heparan sulfate, and laminin) fibroblast growth factor (bFGF), von Willebrand factor (vWF), and 3 MMPs (8, 9, and 13). (uni-bielefeld.de)
  • How is lethal popliteal pterygium syndrome differentiated from arthrogryposis multiplex congenita (AMC)? (medscape.com)
  • Tano T, Ono K, Hiratsuka Y et al (2013) Prevalence of pterygium in a population in Northern Japan: the locomotive syndrome and health outcome in Aizu Cohort Study. (springer.com)
  • Foetal akinesia deformation sequence syndrome (FADS) is a genetically heterogeneous disorder characterised by the combination of foetal akinesia and developmental defects which may include pterygia (joint webbing). (biomedcentral.com)
  • In collaborative studies, his research led to findings of novel IRF6 mutations in families with Van Der Woude syndrome and popliteal pterygium syndrome in Africa (PMID 24936515) and helped identify rare functional variants in non-syndromic cleft lip/palate (PMID 25081408). (genome.gov)
  • Protein-altering MYH3 variants are associated with a spectrum of phenotypes extending to spondylocarpotarsal synostosis syndrome ," European Journal of Human Genetics, vol. (thefreedictionary.com)
  • Conclusions: Our results suggest that a recently identified signal transduction pathway that regulates neural stem cells and glioblastoma cancer stem cells also operates in the ocular surface, ciliary body, and in pterygium. (nottingham.ac.uk)
  • In the left eye, a pterygium , paracentral corneal opacity and a vertically oval pupil were observed. (tripdatabase.com)
  • Zur Gewebelehre der Menschenhornhaut (Lessons on human corneal tissue) in: Virchow's Archiv, 1856, Band X, S. 506f. (wikipedia.org)
  • Pterygium growth can cause irregular astigmatism, corneal scarring, restriction of ocular motility, or chronic ocular surface inflammation (1). (scribd.com)
  • Overexposure to the sun's ultraviolet (UV) rays has been associated with a number of eye problems, including pterygium, corneal degenerative changes, photokeratitis, and age-related cataracts [ 1 - 4 ]. (hindawi.com)
  • Thus, it is possible that reducing oxidative stress in human corneal epithelial cells will improve people's work performance. (hindawi.com)
  • If the Pterygium is progressively increasing in size and there is a risk that it can reach the centre of the corneal surface it is better to surgically excise it. (wordpress.com)
  • When pterygium takes a more aggresive course, it can cause blurred vision by inducing irregular astygmatism, injuries of the corneal stroma and obliteration of the visual axis, as well as ocular irritation through the inflammation of the ocular surface from its site. (escrs.org)
  • It has an advancing portion called the head of the pterygium, which is connected to the main body of the pterygium by the neck. (wikipedia.org)
  • Sometimes a line of iron deposition can be seen adjacent to the head of the pterygium called Stocker's line. (wikipedia.org)
  • If a pterygium is small but becomes intermittently inflamed, the ophthalmologist may recommend the use of a nonsteroidal or a mild steroid eye drop when the inflammation develops. (uclahealth.org)
  • 11 ] demonstrated in a clinical trial that doses of 8 or even 12 g/day were safe for humans. (termedia.pl)
  • National Institutes of Health Building 50 at NIH Clinical Center - Building 10 The National Institutes of Health (NIH) is an agency of the United States Department of Health and Human Services and is the primary agency of the United States government responsible for biomedical research. (statemaster.com)
  • After the primary infection, the human alphaherpesvirinae sub-family remains quiescent in the nerve ganglia from which it can periodically reactivate, causing clinical manifestations. (intechopen.com)
  • We found increased HBD-2 expression in pterygium specimens compared to controls. (escrs.org)
  • We suggest that abnormal expression of p53, p53 codon 72 polymorphisms and HPV DNA are required co-factors for the development of pterygium. (geneticsmr.com)
  • A lot of factors such as genetic, environmental, ocular surface instability, limbal deficiency and atypia play an active role either individually or synergistically in the development of pterygium. (scirp.org)
  • To investigate whether lymphatic microvessel density (LMVD) could be used as a predictive marker for the recurrence time of pterygia. (molvis.org)
  • The recurrence time (RT) for a pterygium was calculated, and its relationship with LMVD and/or BMVD was statistically analyzed. (molvis.org)