Social Work: The use of community resources, individual case work, or group work to promote the adaptive capacities of individuals in relation to their social and economic environments. It includes social service agencies.Laboratory Animal Science: The science and technology dealing with the procurement, breeding, care, health, and selection of animals used in biomedical research and testing.LondonAnimal Welfare: The protection of animals in laboratories or other specific environments by promoting their health through better nutrition, housing, and care.Animals, LaboratoryEvidence-Based Nursing: A way of providing nursing care that is guided by the integration of the best available scientific knowledge with nursing expertise. This approach requires nurses to critically assess relevant scientific data or research evidence, and to implement high-quality interventions for their nursing practice.Nursing Research: Research carried out by nurses, generally in clinical settings, in the areas of clinical practice, evaluation, nursing education, nursing administration, and methodology.Properdin: A 53-kDa protein that is a positive regulator of the alternate pathway of complement activation (COMPLEMENT ACTIVATION PATHWAY, ALTERNATIVE). It stabilizes the ALTERNATIVE PATHWAY C3 CONVERTASE (C3bBb) and protects it from rapid inactivation, thus facilitating the cascade of COMPLEMENT ACTIVATION and the formation of MEMBRANE ATTACK COMPLEX. Individuals with mutation in the PFC gene exhibit properdin deficiency and have a high susceptibility to infections.Cobra Venoms: Venoms from snakes of the genus Naja (family Elapidae). They contain many specific proteins that have cytotoxic, hemolytic, neurotoxic, and other properties. Like other elapid venoms, they are rich in enzymes. They include cobramines and cobralysins.Serum Globulins: All blood proteins except albumin ( = SERUM ALBUMIN, which is not a globulin) and FIBRINOGEN (which is not in the serum). The serum globulins are subdivided into ALPHA-GLOBULINS; BETA-GLOBULINS; and GAMMA-GLOBULINS on the basis of their electrophoretic mobilities. (From Dorland, 28th ed)Guinea Pigs: A common name used for the genus Cavia. The most common species is Cavia porcellus which is the domesticated guinea pig used for pets and biomedical research.Complement System Proteins: Serum glycoproteins participating in the host defense mechanism of COMPLEMENT ACTIVATION that creates the COMPLEMENT MEMBRANE ATTACK COMPLEX. Included are glycoproteins in the various pathways of complement activation (CLASSICAL COMPLEMENT PATHWAY; ALTERNATIVE COMPLEMENT PATHWAY; and LECTIN COMPLEMENT PATHWAY).Immunity: Nonsusceptibility to the invasive or pathogenic effects of foreign microorganisms or to the toxic effect of antigenic substances.Complement C3: A glycoprotein that is central in both the classical and the alternative pathway of COMPLEMENT ACTIVATION. C3 can be cleaved into COMPLEMENT C3A and COMPLEMENT C3B, spontaneously at low level or by C3 CONVERTASE at high level. The smaller fragment C3a is an ANAPHYLATOXIN and mediator of local inflammatory process. The larger fragment C3b binds with C3 convertase to form C5 convertase.Complement Pathway, Alternative: Complement activation initiated by the interaction of microbial ANTIGENS with COMPLEMENT C3B. When COMPLEMENT FACTOR B binds to the membrane-bound C3b, COMPLEMENT FACTOR D cleaves it to form alternative C3 CONVERTASE (C3BBB) which, stabilized by COMPLEMENT FACTOR P, is able to cleave multiple COMPLEMENT C3 to form alternative C5 CONVERTASE (C3BBB3B) leading to cleavage of COMPLEMENT C5 and the assembly of COMPLEMENT MEMBRANE ATTACK COMPLEX.Goats: Any of numerous agile, hollow-horned RUMINANTS of the genus Capra, in the family Bovidae, closely related to the SHEEP.Complement Factor B: A glycine-rich, heat-labile serum glycoprotein that contains a component of the C3 CONVERTASE ALTERNATE PATHWAY (C3bBb). Bb, a serine protease, is generated when factor B is cleaved by COMPLEMENT FACTOR D into Ba and Bb.Neisseria meningitidis: A species of gram-negative, aerobic BACTERIA. It is a commensal and pathogen only of humans, and can be carried asymptomatically in the NASOPHARYNX. When found in cerebrospinal fluid it is the causative agent of cerebrospinal meningitis (MENINGITIS, MENINGOCOCCAL). It is also found in venereal discharges and blood. There are at least 13 serogroups based on antigenic differences in the capsular polysaccharides; the ones causing most meningitis infections being A, B, C, Y, and W-135. Each serogroup can be further classified by serotype, serosubtype, and immunotype.Meningococcal Infections: Infections with bacteria of the species NEISSERIA MENINGITIDIS.Polyanetholesulfonate: A compound originally developed as an anticoagulant, but possessing anticomplement action and lowering the bactericidal action of blood. It is used in vitro to inhibit blood coagulation and as a diagnostic reagent to encourage the growth of pathogens in the blood. It is also used to stabilize colloidal solutions such as milk and gelatin. (From Merck Index, 11th ed)Neisseria gonorrhoeae: A species of gram-negative, aerobic bacteria primarily found in purulent venereal discharges. It is the causative agent of GONORRHEA.Meningitis, Meningococcal: A fulminant infection of the meninges and subarachnoid fluid by the bacterium NEISSERIA MENINGITIDIS, producing diffuse inflammation and peri-meningeal venous thromboses. Clinical manifestations include FEVER, nuchal rigidity, SEIZURES, severe HEADACHE, petechial rash, stupor, focal neurologic deficits, HYDROCEPHALUS, and COMA. The organism is usually transmitted via nasopharyngeal secretions and is a leading cause of meningitis in children and young adults. Organisms from Neisseria meningitidis serogroups A, B, C, Y, and W-135 have been reported to cause meningitis. (From Adams et al., Principles of Neurology, 6th ed, pp689-701; Curr Opin Pediatr 1998 Feb;10(1):13-8)Goat Diseases: Diseases of the domestic or wild goat of the genus Capra.ScandinaviaInternet: A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.Databases, Protein: Databases containing information about PROTEINS such as AMINO ACID SEQUENCE; PROTEIN CONFORMATION; and other properties.User-Computer Interface: The portion of an interactive computer program that issues messages to and receives commands from a user.Software: Sequential operating programs and data which instruct the functioning of a digital computer.Molecular Sequence Annotation: The addition of descriptive information about the function or structure of a molecular sequence to its MOLECULAR SEQUENCE DATA record.Computer Graphics: The process of pictorial communication, between human and computers, in which the computer input and output have the form of charts, drawings, or other appropriate pictorial representation.Proteins: Linear POLYPEPTIDES that are synthesized on RIBOSOMES and may be further modified, crosslinked, cleaved, or assembled into complex proteins with several subunits. The specific sequence of AMINO ACIDS determines the shape the polypeptide will take, during PROTEIN FOLDING, and the function of the protein.ArchivesBiological Science Disciplines: All of the divisions of the natural sciences dealing with the various aspects of the phenomena of life and vital processes. The concept includes anatomy and physiology, biochemistry and biophysics, and the biology of animals, plants, and microorganisms. It should be differentiated from BIOLOGY, one of its subdivisions, concerned specifically with the origin and life processes of living organisms.Periodicals as Topic: A publication issued at stated, more or less regular, intervals.PubMed: A bibliographic database that includes MEDLINE as its primary subset. It is produced by the National Center for Biotechnology Information (NCBI), part of the NATIONAL LIBRARY OF MEDICINE. PubMed, which is searchable through NLM's Web site, also includes access to additional citations to selected life sciences journals not in MEDLINE, and links to other resources such as the full-text of articles at participating publishers' Web sites, NCBI's molecular biology databases, and PubMed Central.Directories as Topic: Lists of persons or organizations, systematically arranged, usually in alphabetic or classed order, giving address, affiliations, etc., for individuals, and giving address, officers, functions, and similar data for organizations. (ALA Glossary of Library and Information Science, 1983)Chlamydophila pneumoniae: A species of CHLAMYDOPHILA that causes acute respiratory infection, especially atypical pneumonia, in humans, horses, and koalas.Deoxyribonuclease BamHI: One of the Type II site-specific deoxyribonucleases (EC 3.1.21.4). It recognizes and cleaves the sequence G/GATCC at the slash. BamHI is from Bacillus amyloliquefaciens N. Numerous isoschizomers have been identified. EC 3.1.21.-.Plasmids: Extrachromosomal, usually CIRCULAR DNA molecules that are self-replicating and transferable from one organism to another. They are found in a variety of bacterial, archaeal, fungal, algal, and plant species. They are used in GENETIC ENGINEERING as CLONING VECTORS.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Base Sequence: The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.Genetic Vectors: DNA molecules capable of autonomous replication within a host cell and into which other DNA sequences can be inserted and thus amplified. Many are derived from PLASMIDS; BACTERIOPHAGES; or VIRUSES. They are used for transporting foreign genes into recipient cells. Genetic vectors possess a functional replicator site and contain GENETIC MARKERS to facilitate their selective recognition.Cloning, Molecular: The insertion of recombinant DNA molecules from prokaryotic and/or eukaryotic sources into a replicating vehicle, such as a plasmid or virus vector, and the introduction of the resultant hybrid molecules into recipient cells without altering the viability of those cells.Escherichia coli: A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc.Candida albicans: A unicellular budding fungus which is the principal pathogenic species causing CANDIDIASIS (moniliasis).Mannans: Polysaccharides consisting of mannose units.Complement Pathway, Classical: Complement activation initiated by the binding of COMPLEMENT C1 to ANTIGEN-ANTIBODY COMPLEXES at the COMPLEMENT C1Q subunit. This leads to the sequential activation of COMPLEMENT C1R and COMPLEMENT C1S subunits. Activated C1s cleaves COMPLEMENT C4 and COMPLEMENT C2 forming the membrane-bound classical C3 CONVERTASE (C4B2A) and the subsequent C5 CONVERTASE (C4B2A3B) leading to cleavage of COMPLEMENT C5 and the assembly of COMPLEMENT MEMBRANE ATTACK COMPLEX.Complement C1q: A subcomponent of complement C1, composed of six copies of three polypeptide chains (A, B, and C), each encoded by a separate gene (C1QA; C1QB; C1QC). This complex is arranged in nine subunits (six disulfide-linked dimers of A and B, and three disulfide-linked homodimers of C). C1q has binding sites for antibodies (the heavy chain of IMMUNOGLOBULIN G or IMMUNOGLOBULIN M). The interaction of C1q and immunoglobulin activates the two proenzymes COMPLEMENT C1R and COMPLEMENT C1S, thus initiating the cascade of COMPLEMENT ACTIVATION via the CLASSICAL COMPLEMENT PATHWAY.Immunoglobulin G: The major immunoglobulin isotype class in normal human serum. There are several isotype subclasses of IgG, for example, IgG1, IgG2A, and IgG2B.Leprosy: A chronic granulomatous infection caused by MYCOBACTERIUM LEPRAE. The granulomatous lesions are manifested in the skin, the mucous membranes, and the peripheral nerves. Two polar or principal types are lepromatous and tuberculoid.Vaccinia virus: The type species of ORTHOPOXVIRUS, related to COWPOX VIRUS, but whose true origin is unknown. It has been used as a live vaccine against SMALLPOX. It is also used as a vector for inserting foreign DNA into animals. Rabbitpox virus is a subspecies of VACCINIA VIRUS.Complement Activation: The sequential activation of serum COMPLEMENT PROTEINS to create the COMPLEMENT MEMBRANE ATTACK COMPLEX. Factors initiating complement activation include ANTIGEN-ANTIBODY COMPLEXES, microbial ANTIGENS, or cell surface POLYSACCHARIDES.RNA Viruses: Viruses whose genetic material is RNA.Phylogeny: The relationships of groups of organisms as reflected by their genetic makeup.
Prater CA, Plotkin J, Jaye D, Frazier WA (Mar 1991). "The properdin-like type I repeats of human thrombospondin contain a cell ... Thrombospondin 1, abbreviated as THBS1, is a protein that in humans is encoded by the THBS1 gene. Thrombospondin 1 is a subunit ... Jaffe E, Bornstein P, Disteche CM (May 1990). "Mapping of the thrombospondin gene to human chromosome 15 and mouse chromosome 2 ... the properdin-like type I repeats, and the globular carboxy-terminal domain. The protein also contains type II repeats with ...
Mejía JE, Jahn I, de la Salle H, Hauptmann G (January 1994). "Human factor B. Complete cDNA sequence of the BF*S allele". Human ... Farries TC, Lachmann PJ, Harrison RA (August 1988). "Analysis of the interaction between properdin and factor B, components of ... Complement factor B is a protein that in humans is encoded by the CFB gene. This gene encodes complement factor B, a component ... Yancey KB, Overholser O, Domloge-Hultsch N, Li LJ, Caughman SW, Bisalbutra P (March 1992). "Human keratinocytes and A-431 cells ...
Nakamura S, Abe K (1985). "Genetic polymorphism of human factor I (C3b inactivator)". Human Genetics. 71 (1): 45-8. doi:10.1007 ... Factor I deficiency in turn leads to low levels of complement component 3 (C3), factor B, factor H and properdin. in plasma, ... The gene for Factor I in humans is located on chromosome 4. Factor I is synthesised mostly in the liver, and is initially ... Complement factor I, also known as C3b/C4b inactivator, is a protein that in humans is encoded by the CFI gene. Complement ...
The properdin stabilizes the alternative pathway C5 convertase of which half-life is at 37 °C 10 - 34 min. In contrast, the ... Cooper NR, Müller-Eberhard HJ (1970). "THE REACTION MECHANISM OF HUMAN C5 IN IMMUNE HEMOLYSIS". J Exp Med. 132: R775-793. doi: ... DiScipio RG, Smith CA, Müller-Eberhard HJ, Hugli TE (1983). "The Activation of Human Complement Component C5 by a Fluid Phase ... Christie DL, Gagnon J, Porter RR (1980). "Partial sequence of human complement component Factor B: Novel type of serine ...
They excluded properdin deficiency, which can be accompanied by susceptibility to meningococcal meningitis, because of its X- ... 1969). "Human immunity to the meningococcus, I: the role of humoral antibodies." J Exp Med;129:1307-1326. ... A study of the virulence of meningococci for man and of human susceptibility to meningococcic infection. J Immunol;7:1-33. ...
Inherited properdin deficiency also is related with an increased risk of contracting meningococcal disease. Because people with ... TI-2 antigens generally are incapable of stimulating an immune response in neonatal humans under 18 months of age. This has ... The use of capsular polysaccharides as immunoprophylactic agents against human disease caused by encapsulated bacteria is now ... Ross SC, Rosenthal PJ, Berberich HM, Densen P (June 1987). "Killing of Neisseria meningitidis by human neutrophils: ...
Properdin deficient individuals are sensitive to pyogenic infections. Properdin also promotes association of C3b with Factor B ... "Formation of classical C3 convertase during the alternative pathway of human complement activation". PubMed Article. Retrieved ... Properdin (Factor P) is the only known positive regulator of complement activation that stabilizes the alternative C3 ... C3b has different binding site for C3bINA, β1H, factor B and properdin. Binding β1H to C3b increases C3bINA binding, while ...
... (EC 3.4.21.46, C3 proactivator convertase, properdin factor D esterase, factor D (complement), complement factor D, ... "Structure of human factor D. A complement system protein at 2.0 A resolution". Journal of Molecular Biology. 235 (2): 695-708. ... CFD, adipsin) a protein which in humans is encoded by the CFD gene. Factor D is involved in the alternative complement pathway ...
Morley, B.J.; Campbell, R.D. (1984). "Internal homologies of the Ba fragment from human complement component Factor B, as a ... properdin factor B, C3 proactivator, glycine-rich beta-glycoprotein, heat-labile factor, C3 convertase, C3b,Bb,CVF,Bb,C5 ... Alternative complement pathway Kerr, M.A. (1981). "Human factor B". Methods Enzymol. 80: 102-112. doi:10.1016/s0076-6879(81) ...
"Molecular Architecture of Human Properdin, a Positive Regulator of the Alternative Pathway of Complement". J Biol Chem. 259: ... Lars Otto Uttenthal Properdin September 01 2005 Properdin at the US National Library of Medicine Medical Subject Headings (MeSH ... Properdin deficiency is a rare X-linked disease in which properdin is deficient. Affected individuals are susceptible to ... The properdin promotes the association of C3b with Factor B and provides a focal point for the assembly of C3bBb on a surface. ...
Hoffecker JF (September 2009). "Out of Africa: modern human origins special feature: the spread of modern humans in Europe". ... Creemers PC, Du Toit ED, Kriel J (December 1995). "DBP (vitamin D binding protein) and BF (properdin factor B) allele ... but this has not been tested in humans. The U.S Institute of Medicine has established a Tolerable Upper Intake Level (UL) to ... "Human plasma transport of vitamin D after its endogenous synthesis". The Journal of Clinical Investigation. 91 (6): 2552-5. doi ...
Properdin then binds to complement C3 in the donor blood, facilitating the reaction through the alternate pathway cascade. The ... The most common cause of this reaction is ABO blood groups incompatibility, secondary to human errors. In this process, the ... "The 2011 National Blood Collection and Utilization Survey Report" (PDF). Department of Health and Human Services. Retrieved 21 ...
In humans, up to a cup (240 ml) of red blood cells can be held in the spleen and released in cases of hypovolemia. It can store ... Other functions of the spleen are less prominent, especially in the healthy adult: Production of opsonins, properdin, and ... In humans the spleen is brownish in color and is located in the left upper quadrant of the abdomen. The spleen, in healthy ... Human spleens have been noted to decrease in volume up to 40% when subjected to stimuli from strenuous exercise or hypoxic gas ...
Immunology at MCG 1/phagocyt Tausk, F.; Gigli, I. (1990-06-01). "The human C3b receptor: function and role in human diseases". ... This C3bBb convertase is stabilized by properdin (Factor P) preferentially on microbial surfaces over normal host surfaces, and ... Holers, V. Michael (2014-01-01). "Complement and Its Receptors: New Insights into Human Disease". Annual Review of Immunology. ... One mechanism, mentioned above, is the stabilization of the C3bBb convertase by properdin preferentially on microbial surfaces ...
Inherited properdin deficiency also is related, with an increased risk of contracting meningococcal disease. Persons with ... Y and W135 are responsible for virtually all cases of the disease in humans. Vaccines are currently available against all six ... "Recurrent meningococcal septicaemia and properdin deficiency". J. Infect. 31 (1): 67-8. doi:10.1016/S0163-4453(95)91550-8. PMID ... "Killing of Neisseria meningitidis by human neutrophils: implications for normal and complement-deficient individuals". J. ...
12th European Meeting on Complement in Human Disease12th European Meeting on CHD12th European Meeting on Complement in Human ... This complex has the ability to catalyze the formation of C3a and C3b after it binds properdin, a globulin protein, and is ... C3a is able to regulate B cell and monocyte production of IL-6 and TNF-α, and human C3a has been shown to dampen the polyclonal ... 15th European Meeting on Complement in Human Disease 2015, Uppsala, Sweden. 67 (1): 101-107. doi:10.1016/j.molimm.2015.02.027. ...
Several single-nucleotide polymorphisms have been described in M-ficolin in humans, with effect on ligand-binding ability and ... Properdin). The stabilized C3 convertase, C3bBbP, then acts enzymatically to cleave much more C3, some of which becomes ...
Inherited properdin deficiency also is related, with an increased risk of contracting meningococcal disease.[27][35] Persons ... Ross SC, Rosenthal PJ, Berberich HM, Densen P (June 1987). "Killing of Neisseria meningitidis by human neutrophils: ... Cunliffe NA, Snowden N, Dunbar EM, Haeney MR (July 1995). "Recurrent meningococcal septicaemia and properdin deficiency". J. ... Y and W135 are responsible for virtually all cases of the disease in humans. Vaccines are currently available against all six ...
The complex is believed to be unstable until it binds properdin, a serum protein. The addition of properdin forms the complex ... May 2005). "Human factor H-related protein 5 has cofactor activity, inhibits C3 convertase activity, binds heparin and C- ... Pangburn MK, Schreiber RD, Müller-Eberhard HJ (July 1977). "Human complement C3b inactivator: isolation, characterization, and ...
The C3bBb complex is stabilized by binding oligomers of factor P (Properdin). The stabilized C3 convertase, C3bBbP, then acts ... Several single-nucleotide polymorphisms have been described in M-ficolin in humans, with effect on ligand-binding ability and ...
Properdin) Middle stage C3 - C3a / C3b / iC3b C5 - C5a C3-convertase C5-convertase Late stage Membrane attack complex (MAC) C6 ... List of immunologists List of autoimmune diseases List of immunologists List of viruses List of human clusters of ...
This article on a gene on human chromosome 12 is a stub. You can help Wikipedia by expanding it.. *v ... C1s is part of the C1 complex.[5][6][7][8] In humans, it is encoded by the C1S gene.[9] ... Human C1S genome location and C1S gene details page in the UCSC Genome Browser. ... Sim RB (1981). "The human complement system serine proteases C1r and C1s and their proenzymes". Methods in Enzymology. 80 Pt C ...
However, human studies have found that degalactosylation of IgA1 occurs in patients with IgA nephropathy in response only to ... Immunoflourescence shows mesangial deposition of IgA often with C3 and properdin and smaller amounts of other immunoglobulins ( ...
Stanley KK, Marazziti D, Eggertsen G, Fey GH (1988). "Relationships between the gene and protein structure in human complement ... "Nucleotide sequence of cDNA and derived amino acid sequence of human complement component C9". Proc. Natl. Acad. Sci. U.S.A ... "The sequence and topology of human complement component C9". EMBO J. 4 (2): 375-382. PMC 554196. PMID 4018030 ...
... corresponding to a human age of 55 years) to 26-27 months of age (corresponding to a human age of 80 years), during which time ... baicalein, human hepatoma cell line HepG2 was assigned to grow in different media for four days, followed by the investigation ... More specifically, an in-vitro assay showed that at concentrations that induce GSH synthesis in normal human cells, a specially ... Glutathione is the major antioxidant in human cells.. Objectives: To determine if a nondenatured bioactive whey protein isolate ...
"Human tyrosine kinase 2 deficiency reveals its requisite roles in multiple cytokine signals involved in innate and acquired ... Properdin deficiency. *Complement 3 deficiency. *Terminal complement pathway deficiency. *Paroxysmal nocturnal hemoglobinuria ... "Human TYK2 deficiency: Mycobacterial and viral infections without hyper-IgE syndrome". The Journal of Experimental Medicine ...
Buy our Recombinant Human Properdin protein. Ab114924 is a protein fragment produced in Wheat germ and has been validated in WB ... Defects in CFP are the cause of properdin deficiency (PFD) [MIM:312060]. PFD results in higher susceptibility to bacterial ...
References for Abcams Recombinant Human Properdin protein (ab114924). Please let us know if you have used this product in your ...
Anti-Human. Host: goat. Form: liquid. Conc/Titer: 1:4. Applications: Ouchterlony double diffusion. ... Unless specified otherwise, MP Biomedicals products are for laboratory research use only, not for human or clinical use. For ...
CFB Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 528 aa (260-764) having a ... CFB Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 528 amino acids (260-764) ... Complement factor B (EC:3.4.21.47), C3/C5 convertase, Glycine-rich beta glycoprotein, GBG, PBF2, Properdin factor B, Complement ...
Studies on the Properdin System: Isolation of a Heat-Labile Factor from Guinea Pig Serum Related to a Human Glycine-Rich Beta- ... Studies on the Properdin System: Isolation of a Heat-Labile Factor from Guinea Pig Serum Related to a Human Glycine-Rich Beta- ... Studies on the Properdin System: Isolation of a Heat-Labile Factor from Guinea Pig Serum Related to a Human Glycine-Rich Beta- ... Studies on the Properdin System: Isolation of a Heat-Labile Factor from Guinea Pig Serum Related to a Human Glycine-Rich Beta- ...
Purification and fractionation of properdin. Properdin was purified from normal human plasma as described (45) and stored at − ... Unfractionated properdin contains high-order oligomers of properdin formed as a result of freeze thawing (35). Properdin in ... C3 deposition on Neisseria decreased markedly when properdin function was blocked using an anti-properdin mAb or when properdin ... Properdin that bound to bacteria or zymosan was detected using anti-human properdin mAb (Quidel catalog no. A235) at a dilution ...
Structural Basis for Properdin Oligomerization and Convertase Stimulation in the Human Complement System.. Pedersen, D.V., ... Crystallization and X-ray analysis of monodisperse human properdin.. Pedersen, D.V., Revel, M., Gadeberg, T.A.F.,& ... Properdin (FP) is a positive regulator of the immune system stimulating the activity of the proteolytically active C3 ... Properdin (FP) is a positive regulator of the immune system stimulating the activity of the proteolytically active C3 ...
Fluorescein conjugated polyclonal goat antiserum to Human Complement Properdin ... Anti Human Properdin FITC Version or Model:. 1 Catalog Number:. 108202 Company Name:. KENT LABORATORIES INC ... Human Cell, Tissue or Cellular or Tissue-Based Product (HCT/P):. No ...
"Molecular Architecture of Human Properdin, a Positive Regulator of the Alternative Pathway of Complement". J Biol Chem. 259: ... Lars Otto Uttenthal Properdin September 01 2005 Properdin at the US National Library of Medicine Medical Subject Headings (MeSH ... Properdin deficiency is a rare X-linked disease in which properdin is deficient. Affected individuals are susceptible to ... The properdin promotes the association of C3b with Factor B and provides a focal point for the assembly of C3bBb on a surface. ...
Human brain; WB Suggested Anti-CFP Antibody Titration: 0.2-1 ug/ml. ELISA Titer: 1:312500. Positive Control: Human brain; CFP ... Human Thymus; WB Suggested Anti-CFP Antibody Titration: 0.2-1 ug/ml. ELISA Titer: 1:1562500. Positive Control: Human Thymus; ... Background of Properdin antibody. Kit Component:. - KN303219G1, Cfp gRNA vector 1 in pCas-Guide vector. - KN303219G2, Cfp gRNA ... Hu (Human), Bov (Bovine), Can (Canine), Ms (Mouse), Rt (Rat), Eq (Equine), GP (Guinea Pig) ...
... goat serum against human properdin \ GAHu/PPD for more molecular products just contact us ... goat serum against human properdin Human samples 80 % of the research is conducted on human samples. GENTAUR suppliers human ... We have also other products like : goat serum against human properdin. Related products : goat serum against human properdin ... Index / Nordic Immunological Lab / goat serum against human properdin / Product Detail : GAHu/PPD goat serum against human ...
Properdin was purified from normal human serum (NHS) as described previously (12). Properdin-depleted serum was purchased from ... To further define the role of properdin, native properdin was added back to the properdin-depleted serum and this reduced the ... induces complement activation using normal human serum. The P3 form of properdin was isolated from purified properdin by ion- ... We have determined for the first time that the physiological P2, P3, and P4 forms of human properdin bind to the surface of ...
Characterization of the human properdin gene. Biochemical Journal 1992, 287, 291-297. ... Characterization of Mutant Forms of Recombinant Human Properdin Lacking Single Thrombospondin Type I Repeats: Identification of ... We are particularly interested in how histone kinases such as Haspin and Aurora B control cell division in human cells, how ... The crystal structure of human E-cadherin domains 1 and 2, and comparison with other cadherins in the context of adhesion ...
Purification and Functional Analysis of Human Properdin Joseph OFlynn, Maria C. Faber Krol, Mohamed R. Daha, Cees van Kooten ... activation in humans activation in model animals complement system complement system activation disease health homeostasis ... Classical Complement Pathway Component C1q: Purification of Human C1q, Isolation of C1q Collagen-Like and Globular Head ... Classical Complement Pathway Components C1r and C1s: Purification from Human Serum and in Recombinant Form and Functional ...
MMWR and Morbidity and Mortality Weekly Report are service marks of the U.S. Department of Health and Human Services.. Use of ... properdin, Factor D, Factor H, or C5-C9); persons receiving eculizumab (Soliris, Alexion Pharmaceuticals) for treatment of ... A growing body of evidence supports an increased risk for meningococcal disease in human immunodeficiency virus (HIV)-infected ... Immunogenicity and safety of 1 vs 2 doses of quadrivalent meningococcal conjugate vaccine in youth infected with human ...
Human chromosome 19: entries, gene names and cross-references to MIM. *Human entries with polymorphisms or disease mutations. ... Human polymorphisms and disease mutations. Index of human polymorphisms and disease mutations ... Properdin factor D. ,p>This subsection of the ,a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and ... "Human adipsin is identical to complement factor D and is expressed at high levels in adipose tissue.". White R.T., Damm D., ...
Prater CA, Plotkin J, Jaye D, Frazier WA (Mar 1991). "The properdin-like type I repeats of human thrombospondin contain a cell ... Thrombospondin 1, abbreviated as THBS1, is a protein that in humans is encoded by the THBS1 gene. Thrombospondin 1 is a subunit ... Jaffe E, Bornstein P, Disteche CM (May 1990). "Mapping of the thrombospondin gene to human chromosome 15 and mouse chromosome 2 ... the properdin-like type I repeats, and the globular carboxy-terminal domain. The protein also contains type II repeats with ...
Complement Factor Properdin, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The ... View all 3 R&D Systems CFP (Properdin) Products. *View all R&D Systems CFP (Properdin) Proteins and Enzymes*Recombinant Human ... View all R&D Systems CFP (Properdin) Primary Antibodies*Human/Mouse/Rat Properdin Antibody (AF8216) ... G Biosciences Immunotag™ Human CFP (Properdin) ELISA and Immunotag™ Properdin ELISA Kit ...
Properdin deficiency. *Human Immunodeficiency Virus (HIV). *Close living areas. *College students in dormitories ...
... protein found in the blood serum of humans and some of the higher animals that appears to participate in certain specific ... properdin (prō´pərdən), protein found in the blood serum of humans and some of the higher animals that appears to participate ... properdin (proh-per-din) n. a group of substances in blood plasma that, in combination with complement and magnesium ions, is ... properdin A Dictionary of Nursing © A Dictionary of Nursing 2008, originally published by Oxford University Press 2008. ...
Properdin is synthesized by monocytes and T lymphocytes. Properdin binds to C3bBb and stabilizes it, preventing its decay. ... Table 3. Proteins of the Human Complement (C) System, Lectin Pathway *Table 4. Proteins of the Human Complement (C) System, C3 ... Table 1. Proteins of the Human Complement (C) System, Classical Pathway* *Table 2. Proteins of the Human Complement (C) System ... Table 6. Proteins of the Human Complement (C) System, Membrane Receptor and Control Proteins (Open Table in a new window) ...
Aviva Systems Biology CFD ELISA Kit (Human) : 96 Wells (OKEH02689) and CFD ELISA Kit (Human) (OKCD07712) ... Properdin Factor D 2 3 4 * D Component Of Complement (Adipsin) 2 3 ... P00746-CFAD_HUMAN. Recommended name:. Complement factor D. Protein Accession:. P00746. Secondary Accessions: *B4DV76 ... Human adipsin is identical to complement factor D and is expressed at high levels in adipose tissue. (PMID: 1374388) White RT ...
Human papillomavirus vaccine. *individuals, up to 26 years of age who self-identify as MSM (gay, bisexual or transgender). ... complement, properdin, factor D deficiency or primary antibody deficiencies. *pre/post cochlear implant recipients ... Human immunodeficiency viruses (HIV) or acquired complement deficiency. Menactra®/Menveo® is licensed up to age 55; its use for ... Toronto Public Health provides free hepatitis B, meningococcal and human papillomavirus vaccinations to Grade 7/8 students in ...
Human-pathogenic microbes possess various means to avoid destruction by our immune system. These include interactions with the ... Human-pathogenic microbes possess various means to avoid destruction by our immune system. These include interactions with the ... In humans, five CFHR genes are found adjacent to the CFH gene and code for five distinct FHR proteins. These proteins have ... Properdin is a positive regulator of complement activation. Recently, the FH-related (FHR) proteins have emerged as additional ...
A factor present in fresh normal human or guinea pig serum enhances the primary atypical pneumonia (PAP) antibody titers in ... This factor is not properdin. It has many properties similar to complement but may not be identical with complement. The ... addition of this enhancement factor to human sera convalescent from primary atypical pneumonia has made the serological test ...
  • We crossed DAF(-/-)CD59(-/-) mice with mice deficient in various complement components or receptors including C3, C4, factor B (fB), factor properdin (fP), mannose-binding lectin, C3aR, C5aR, or Ig and assessed renal IRI in the resulting mutant strains. (jove.com)
  • Both SMIPPs exerted their inhibitory action due to binding of three molecules involved in the three different mechanisms which initiate complement: C1q, mannose-binding lectin, and properdin. (edu.au)
  • In vitro assays for the first time point to the significant role of properdin in infection with L. monocytogenes: using dendritic cells and macrophages derived from the bone marrows of properdin-deficient (KO) and wild type mice (WT), cells from WT mice showed greater intracellular load of viable L. monocytogenes at an early time point. (bl.uk)
  • In vivo experiments demonstrated for the first time that properdin is necessary in the survival of acute murine listeriosis: properdin-deficient mice were more susceptible to intravenous infection with L. monocytogenes compared to wild type mice, and had a greater systemic IFN-gamma and splenic IL-17A response and greater disease severity with impaired M1 type activation. (bl.uk)
  • Properdin-deficient mice developed less severe CAIA than did WT mice. (biomedcentral.com)
  • OSCAR is a collagen receptor that costimulates osteoclastogenesis in DAP12-deficient humans and mice. (labome.org)
  • A breakthrough study done at the University of Leicester in the UK has shown that low dose injections of artificial properdin provide substantial protection against septic diseases in mice. (thirdage.com)
  • The study, funded by the Medical Research Council (MRC), found artificially produced properdin (Pn) to be 100 times more efficient at fighting infection than naturally occurring properdin, offering significant protection in mice against Streptococcus pneumoniae and Neisseria meningitidis infections. (thirdage.com)
  • First, in both mice and humans, ILC3s were found to be a key source of a cytokine called GM-CSF, which recruits additional immune cells that further promote intestinal inflammation. (elifesciences.org)
  • Oral administration of CCX168, a small molecule antagonist of human C5aR/CD88, ameliorated anti-MPO-induced NCGN in mice expressing human C5aR/CD88. (asnjournals.org)
  • 1 , 2 Injection of anti-MPO antibodies into mice causes NCGN and vasculitis, closely mimicking human AAV. (asnjournals.org)
  • Thrombospondin's activity has been mapped to several domains, in particular the amino-terminal heparin-binding domain, the procollagen domain, the properdin-like type I repeats, and the globular carboxy-terminal domain. (wikipedia.org)
  • In conclusion, the physiological forms of properdin do not bind directly to either N. meningitidis or N. gonorrhoeae but play a crucial role in augmenting AP-dependent C3 deposition on the bacteria through the "conventional" mechanism of stabilizing AP C3 convertases. (jimmunol.org)
  • Membrane attack complex (MAC), properdin (P), factor H (fH) and Complement receptor type 1 (CR1) were quantified in urine samples from 71 patients with IgAN and 72 healthy controls. (biomedcentral.com)
  • A man-portable membrane inlet mass spectrometer has been built and tested to detect and monitor characteristic odors emitted from the human body and also from threat substances. (jove.com)
  • In addition, peptides from TSP-1 type 1 properdin repeats can compete with bFGF for binding to endothelial cells and prevent their bFGF-induced proliferation and migration ( 22 ). (rupress.org)
  • Each properdin monomer is a 53 kDa molecule. (jimmunol.org)
  • Altogether, our data suggest that properdin is a pattern recognition molecule that plays a role in resistance to Chlamydia infection. (pubmedcentralcanada.ca)
  • A team led by Wilhelm Schwaeble at the University of Leicester in the UK and involving researchers from Saudi Arabia, Egypt, Iraq and Pakistan, including Youssif Mohammed Ali, from both the University of Leicester and Mansoura University, Egypt, found that low levels of properdin (Pn) - a long synthetic polymer of physiologic properdin - activates the complement system more so than the native molecule, publishing their findings in PNAS . (natureasia.com)
  • Depending on the epitopes used human ELISA kits can be cross reactive to many other species. (gentaur.com)
  • The Monarch Initiative brings together data about this condition from humans and other species to help physicians and biomedical researchers. (cdc.gov)
  • The properdin promotes the association of C3b with Factor B and provides a focal point for the assembly of C3bBb on a surface. (wikipedia.org)
  • The stabilization of C3bBb by activated properdin minimizes intrinsic decay and protects C3b in the bimolecular complex from C3b inactivator. (pnas.org)
  • Recent studies have shown that properdin can bind directly to AP activator surfaces, such as zymosan and rabbit erythrocytes ( 6 ), and serve to initiate the AP by forming a platform for assembly of AP C3 convertases ( 6 , 7 ). (jimmunol.org)
  • In plasma, properdin exists as cyclic dimers (P 2 ), trimers (P 3 ), and tetramers (P 4 ) formed by head-to-tail association of monomers ( 1 - 3 ). (jimmunol.org)
  • Properdin is composed of cyclic dimers, trimers, and tetramers of a 53-kDa monomeric subunit. (embl.de)
  • The purpose of the project was to characterise the contribution of properdin in the response to L. monocytogenes (EGD-e), a Gram-positive, intracellular pathogen, which can cause severe infectious disease in human and animals, by using in vitro and in vivo methods. (bl.uk)
  • Exsera has years of experience performing in vitro testing with human and animal serum. (exserabiolabs.org)
  • Properdin "nicked" in TSR5 is unable to bind C3b but retains its overall structure and its ability to bind sulfatide. (embl.de)
  • Properdin lacking TSR4 is unable to stabilize the C3b-Bb complex but is able to bind C3b and sulfatide, and shows the presence of monomers and dimers in an electron microscope. (embl.de)
  • In humans, Chlamydia pneumoniae causes diseases of the respiratory tract, e.g., bronchitis, sinusitis, or pneumonia, with potentially severe sequelae that include atherosclerosis and chronic obstructive pulmonary disease ( 2 , 8 , 20 ). (pubmedcentralcanada.ca)
  • Genetic analyses reveal a clear association of CFH with different human diseases, including diseases of the kidney, the atypical form of Hemolytic Uremic Syndrome (aHUS) and membranoproliferative glomerulonephritis (MPGN), and of the eye, age-related macular degeneration (AMD). (profacgen.com)