Metapneumovirus: A genus of the subfamily PNEUMOVIRINAE, containing two members: Turkey rhinotracheitis virus and a human Metapneumovirus. Virions lack HEMAGGLUTININ and NEURAMINIDASE.Paramyxoviridae Infections: Infections with viruses of the family PARAMYXOVIRIDAE. This includes MORBILLIVIRUS INFECTIONS; RESPIROVIRUS INFECTIONS; PNEUMOVIRUS INFECTIONS; HENIPAVIRUS INFECTIONS; AVULAVIRUS INFECTIONS; and RUBULAVIRUS INFECTIONS.Parainfluenza Virus 3, Human: A species of RESPIROVIRUS frequently isolated from small children with pharyngitis, bronchitis, and pneumonia.Parainfluenza Virus 2, Human: A species of RUBULAVIRUS associated particularly with acute laryngotracheitis (CROUP) in children aged 6 months to 3 years.Respirovirus: A genus of the family PARAMYXOVIRIDAE (subfamily PARAMYXOVIRINAE) where all the virions have both HEMAGGLUTININ and NEURAMINIDASE activities and encode a non-structural C protein. SENDAI VIRUS is the type species.Parainfluenza Virus 1, Human: A species of RESPIROVIRUS also called hemadsorption virus 2 (HA2), which causes laryngotracheitis in humans, especially children.Respiratory Tract Infections: Invasion of the host RESPIRATORY SYSTEM by microorganisms, usually leading to pathological processes or diseases.Parainfluenza Virus 3, Bovine: A species of RESPIROVIRUS, subfamily PARAMYXOVIRINAE, most often seen in conjunction with a secondary infection of MANNHEIMIA HAEMOLYTICA resulting in pneumonic pasteurellosis (PASTEURELLOSIS, PNEUMONIC).Parainfluenza Virus 5: A species of RUBULAVIRUS originally isolated from cultured primary monkey cells. Its natural host is the DOG in which it causes kennel cough, but it can also infect humans.Rubulavirus Infections: Infections with viruses of the genus RUBULAVIRUS, family PARAMYXOVIRIDAE.Pneumovirinae: A subfamily of PARAMYXOVIRIDAE containing two genera: PNEUMOVIRUS; and METAPNEUMOVIRUS.Parainfluenza Vaccines: Vaccines or candidate vaccines used to prevent infection with parainfluenza viruses in humans and animals.Parainfluenza Virus 4, Human: A species of RUBULAVIRUS causing endemic upper respiratory infections in children. It produces only a mild clinical disease and often goes undetected.Respirovirus Infections: Infections with viruses of the genus RESPIROVIRUS, family PARAMYXOVIRIDAE. Host cell infection occurs by adsorption, via HEMAGGLUTININ, to the cell surface.Viral Fusion Proteins: Proteins, usually glycoproteins, found in the viral envelopes of a variety of viruses. They promote cell membrane fusion and thereby may function in the uptake of the virus by cells.Respiratory Syncytial Viruses: A group of viruses in the PNEUMOVIRUS genus causing respiratory infections in various mammals. Humans and cattle are most affected but infections in goats and sheep have also been reported.Rubulavirus: A genus of the family PARAMYXOVIRIDAE (subfamily PARAMYXOVIRINAE) where all the species have hemagglutinin and neuraminidase activities but lack a C protein. MUMPS VIRUS is the type species.Respiratory Syncytial Virus, Human: The type species of PNEUMOVIRUS and an important cause of lower respiratory disease in infants and young children. It frequently presents with bronchitis and bronchopneumonia and is further characterized by fever, cough, dyspnea, wheezing, and pallor.Respiratory Syncytial Virus Infections: Pneumovirus infections caused by the RESPIRATORY SYNCYTIAL VIRUSES. Humans and cattle are most affected but infections in goats and sheep have been reported.HN Protein: Glycoprotein from Sendai, para-influenza, Newcastle Disease, and other viruses that participates in binding the virus to cell-surface receptors. The HN protein possesses both hemagglutinin and neuraminidase activity.Nasopharynx: The top portion of the pharynx situated posterior to the nose and superior to the SOFT PALATE. The nasopharynx is the posterior extension of the nasal cavities and has a respiratory function.Virus Diseases: A general term for diseases produced by viruses.Paramyxoviridae: A family of spherical viruses, of the order MONONEGAVIRALES, somewhat larger than the orthomyxoviruses, and containing single-stranded RNA. Subfamilies include PARAMYXOVIRINAE and PNEUMOVIRINAE.Sigmodontinae: A subfamily of the family MURIDAE comprised of 69 genera. New World mice and rats are included in this subfamily.Viruses: Minute infectious agents whose genomes are composed of DNA or RNA, but not both. They are characterized by a lack of independent metabolism and the inability to replicate outside living host cells.Pneumonia, Viral: Inflammation of the lung parenchyma that is caused by a viral infection.Paramyxovirinae: A subfamily of PARAMYXOVIRIDAE. Genera include RUBULAVIRUS; RESPIROVIRUS; MORBILLIVIRUS; HENIPAVIRUS; and AVULAVIRUS.Cercopithecus aethiops: A species of CERCOPITHECUS containing three subspecies: C. tantalus, C. pygerythrus, and C. sabeus. They are found in the forests and savannah of Africa. The African green monkey (C. pygerythrus) is the natural host of SIMIAN IMMUNODEFICIENCY VIRUS and is used in AIDS research.Vero Cells: A CELL LINE derived from the kidney of the African green (vervet) monkey, (CERCOPITHECUS AETHIOPS) used primarily in virus replication studies and plaque assays.Antibodies, Viral: Immunoglobulins produced in response to VIRAL ANTIGENS.Virus Cultivation: Process of growing viruses in live animals, plants, or cultured cells.Seasons: Divisions of the year according to some regularly recurrent phenomena usually astronomical or climatic. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)Viral Proteins: Proteins found in any species of virus.Virus Replication: The process of intracellular viral multiplication, consisting of the synthesis of PROTEINS; NUCLEIC ACIDS; and sometimes LIPIDS, and their assembly into a new infectious particle.Child, Hospitalized: Child hospitalized for short term care.Phylogeny: The relationships of groups of organisms as reflected by their genetic makeup.RNA, Viral: Ribonucleic acid that makes up the genetic material of viruses.Nasal Lavage Fluid: Fluid obtained by THERAPEUTIC IRRIGATION or washout of the nasal cavity and NASAL MUCOSA. The resulting fluid is used in cytologic and immunologic assays of the nasal mucosa such as with the NASAL PROVOCATION TEST in the diagnosis of nasal hypersensitivity.Sendai virus: The type species of RESPIROVIRUS in the subfamily PARAMYXOVIRINAE. It is the murine version of HUMAN PARAINFLUENZA VIRUS 1, distinguished by host range.Orthomyxoviridae: A family of RNA viruses causing INFLUENZA and other diseases. There are five recognized genera: INFLUENZAVIRUS A; INFLUENZAVIRUS B; INFLUENZAVIRUS C; ISAVIRUS; and THOGOTOVIRUS.Human bocavirus: A member of the family PARVOVIRIDAE, subfamily PARVOVIRINAE, originally isolated from human nasopharyngeal aspirates in patients with respiratory disease.Fluorescent Antibody Technique, Direct: A form of fluorescent antibody technique utilizing a fluorochrome conjugated to an antibody, which is added directly to a tissue or cell suspension for the detection of a specific antigen. (Bennington, Saunders Dictionary & Encyclopedia of Laboratory Medicine and Technology, 1984)Viral Vaccines: Suspensions of attenuated or killed viruses administered for the prevention or treatment of infectious viral disease.Cell Line: Established cell cultures that have the potential to propagate indefinitely.Respiratory System: The tubular and cavernous organs and structures, by means of which pulmonary ventilation and gas exchange between ambient air and the blood are brought about.Coronavirus: A genus of the family CORONAVIRIDAE which causes respiratory or gastrointestinal disease in a variety of vertebrates.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Reverse Transcriptase Polymerase Chain Reaction: A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.RNA Viruses: Viruses whose genetic material is RNA.Neutralization Tests: The measurement of infection-blocking titer of ANTISERA by testing a series of dilutions for a given virus-antiserum interaction end-point, which is generally the dilution at which tissue cultures inoculated with the serum-virus mixtures demonstrate cytopathology (CPE) or the dilution at which 50% of test animals injected with serum-virus mixtures show infectivity (ID50) or die (LD50).Pharynx: A funnel-shaped fibromuscular tube that conducts food to the ESOPHAGUS, and air to the LARYNX and LUNGS. It is located posterior to the NASAL CAVITY; ORAL CAVITY; and LARYNX, and extends from the SKULL BASE to the inferior border of the CRICOID CARTILAGE anteriorly and to the inferior border of the C6 vertebra posteriorly. It is divided into the NASOPHARYNX; OROPHARYNX; and HYPOPHARYNX (laryngopharynx).Infant, Newborn: An infant during the first month after birth.Mumps virus: The type species of RUBULAVIRUS that causes an acute infectious disease in humans, affecting mainly children. Transmission occurs by droplet infection.Bronchiolitis, Viral: An acute inflammatory disease of the lower RESPIRATORY TRACT, caused by paramyxoviruses, occurring primarily in infants and young children; the viruses most commonly implicated are PARAINFLUENZA VIRUS TYPE 3; RESPIRATORY SYNCYTIAL VIRUS, HUMAN; and METAPNEUMOVIRUS.Virology: The study of the structure, growth, function, genetics, and reproduction of viruses, and VIRUS DISEASES.Respiratory Tract DiseasesBronchiolitis: Inflammation of the BRONCHIOLES.Influenza, Human: An acute viral infection in humans involving the respiratory tract. It is marked by inflammation of the NASAL MUCOSA; the PHARYNX; and conjunctiva, and by headache and severe, often generalized, myalgia.Receptors, Virus: Specific molecular components of the cell capable of recognizing and interacting with a virus, and which, after binding it, are capable of generating some signal that initiates the chain of events leading to the biological response.Lung: Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood.Mesocricetus: A genus of the family Muridae having three species. The present domesticated strains were developed from individuals brought from Syria. They are widely used in biomedical research.Nasal Mucosa: The mucous lining of the NASAL CAVITY, including lining of the nostril (vestibule) and the OLFACTORY MUCOSA. Nasal mucosa consists of ciliated cells, GOBLET CELLS, brush cells, small granule cells, basal cells (STEM CELLS) and glands containing both mucous and serous cells.Antigens, Viral: Substances elaborated by viruses that have antigenic activity.Vaccinia virus: The type species of ORTHOPOXVIRUS, related to COWPOX VIRUS, but whose true origin is unknown. It has been used as a live vaccine against SMALLPOX. It is also used as a vector for inserting foreign DNA into animals. Rabbitpox virus is a subspecies of VACCINIA VIRUS.Cricetinae: A subfamily in the family MURIDAE, comprising the hamsters. Four of the more common genera are Cricetus, CRICETULUS; MESOCRICETUS; and PHODOPUS.Neuraminidase: An enzyme that catalyzes the hydrolysis of alpha-2,3, alpha-2,6-, and alpha-2,8-glycosidic linkages (at a decreasing rate, respectively) of terminal sialic residues in oligosaccharides, glycoproteins, glycolipids, colominic acid, and synthetic substrate. (From Enzyme Nomenclature, 1992)Multiplex Polymerase Chain Reaction: Methods for using more than one primer set in a polymerase chain reaction to amplify more than one segment of the target DNA sequence in a single reaction.Acute Disease: Disease having a short and relatively severe course.Croup: Inflammation involving the GLOTTIS or VOCAL CORDS and the subglottic larynx. Croup is characterized by a barking cough, HOARSENESS, and persistent inspiratory STRIDOR (a high-pitched breathing sound). It occurs chiefly in infants and children.Sequence Analysis, DNA: A multistage process that includes cloning, physical mapping, subcloning, determination of the DNA SEQUENCE, and information analysis.Membrane Fusion: The adherence and merging of cell membranes, intracellular membranes, or artificial membranes to each other or to viruses, parasites, or interstitial particles through a variety of chemical and physical processes.Vaccines, Attenuated: Live vaccines prepared from microorganisms which have undergone physical adaptation (e.g., by radiation or temperature conditioning) or serial passage in laboratory animal hosts or infected tissue/cell cultures, in order to produce avirulent mutant strains capable of inducing protective immunity.Viral Plaque Assay: Method for measuring viral infectivity and multiplication in CULTURED CELLS. Clear lysed areas or plaques develop as the VIRAL PARTICLES are released from the infected cells during incubation. With some VIRUSES, the cells are killed by a cytopathic effect; with others, the infected cells are not killed but can be detected by their hemadsorptive ability. Sometimes the plaque cells contain VIRAL ANTIGENS which can be measured by IMMUNOFLUORESCENCE.Genome, Viral: The complete genetic complement contained in a DNA or RNA molecule in a virus.Laryngitis: Inflammation of the LARYNGEAL MUCOSA, including the VOCAL CORDS. Laryngitis is characterized by irritation, edema, and reduced pliability of the mucosa leading to VOICE DISORDERS such as APHONIA and HOARSENESS.Polymerase Chain Reaction: In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.Genes, Viral: The functional hereditary units of VIRUSES.Hemagglutination Inhibition Tests: Serologic tests in which a known quantity of antigen is added to the serum prior to the addition of a red cell suspension. Reaction result is expressed as the smallest amount of antigen which causes complete inhibition of hemagglutination.Amino Acid Sequence: The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.Cytopathogenic Effect, Viral: Visible morphologic changes in cells infected with viruses. It includes shutdown of cellular RNA and protein synthesis, cell fusion, release of lysosomal enzymes, changes in cell membrane permeability, diffuse changes in intracellular structures, presence of viral inclusion bodies, and chromosomal aberrations. It excludes malignant transformation, which is CELL TRANSFORMATION, VIRAL. Viral cytopathogenic effects provide a valuable method for identifying and classifying the infecting viruses.Measles virus: The type species of MORBILLIVIRUS and the cause of the highly infectious human disease MEASLES, which affects mostly children.Virus Assembly: The assembly of VIRAL STRUCTURAL PROTEINS and nucleic acid (VIRAL DNA or VIRAL RNA) to form a VIRUS PARTICLE.Immunocompromised Host: A human or animal whose immunologic mechanism is deficient because of an immunodeficiency disorder or other disease or as the result of the administration of immunosuppressive drugs or radiation.Base Sequence: The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.Glycoproteins: Conjugated protein-carbohydrate compounds including mucins, mucoid, and amyloid glycoproteins.Cell Fusion: Fusion of somatic cells in vitro or in vivo, which results in somatic cell hybridization.Antiviral Agents: Agents used in the prophylaxis or therapy of VIRUS DISEASES. Some of the ways they may act include preventing viral replication by inhibiting viral DNA polymerase; binding to specific cell-surface receptors and inhibiting viral penetration or uncoating; inhibiting viral protein synthesis; or blocking late stages of virus assembly.Respiratory Syncytial Virus Vaccines: Vaccines or candidate vaccines used to prevent infection with RESPIRATORY SYNCYTIAL VIRUSES.Antibodies, Neutralizing: Antibodies that reduce or abolish some biological activity of a soluble antigen or infectious agent, usually a virus.Rhinovirus: A genus of PICORNAVIRIDAE inhabiting primarily the respiratory tract of mammalian hosts. It includes over 100 human serotypes associated with the COMMON COLD.Hospitalization: The confinement of a patient in a hospital.

*Sinusitis

... human parainfluenza viruses, human respiratory syncytial virus, enteroviruses other than rhinoviruses, and metapneumovirus. If ... Most cases are caused by a viral infection. A bacterial infection may be present if symptoms last more than ten days or if a ... Viral sinusitis typically lasts for 7 to 10 days, whereas bacterial sinusitis is more persistent. Approximately 0.5% to 2% of ... Health care providers distinguish bacterial and viral sinusitis by watchful waiting. If a person has had sinusitis for fewer ...

*Human coronavirus NL63

... influenza A virus, respiratory syncytial virus (RSV), parainfluenza virus, and human metapneumovirus (hMPV). The Center for ... Viral culture or blood serum testing for antibodies may also be used for the confirmation of infection. It is believed that the ... Further studies confirmed that the virus is not an emerging virus, but rather one that continually circulates the human ... The virus can survive for up to a week in outside of the body in aqueous solutions at room temperature and three hours on dry ...

*Gregory Prince

Contribution of the Human Parainfluenza Virus Type 3 HN-Receptor Interaction to Pathogenesis In Vivo". Journal of Virology (24 ... Marie-Ève Hamelin; Gregory A. Prince; Ana M. Gomez; Richard Kinkead; Guy Boivin (2006). "Human Metapneumovirus Infection ... Marina S. Boukhvalova; Gregory A. Prince; Jorge C. G. Blanco (2009). "The cotton rat model of respiratory viral infections". ... Gregory A. Prince; David D. Porter (1996). "Treatment of Parainfluenza Virus Type 3 Bronchiolitis and Pneumonia in a Cotton Rat ...

*Negative-sense single-stranded RNA virus

Mumps virus (Paramyxoviridae) Human respiratory syncytial virus (Paramyxoviridae) Parainfluenza (Paramyxoviridae) Rabies ( ... includes Measles virus, Mumps virus, Nipah virus, Hendra virus, and NDV Family Pneumoviridae - includes RSV and Metapneumovirus ... The virus first infects the host cell by binding to the host cell receptor through a viral surface glycoprotein. The fusion of ... Samuel, Charles E (2005). "Virus-Host Interaction Minireview Series: Human Immunodeficiency Virus, Hepatitis C Virus, and ...

*Bronchiolitis

... also known as human pneumovirus). Other viruses which may cause this illness include metapneumovirus, influenza, parainfluenza ... Bronchiolitis is usually the result of infection by respiratory syncytial virus (72% of cases) or human rhinovirus (26% of ... Tests such as a chest X-ray or viral testing are not routinely needed. Urine testing may be considered in those with a fever. ... Bronchiolitis is blockage of the small airway in the lungs due to a viral infection. It usually only occurs in children less ...

*Community-acquired pneumonia

Viruses include human respiratory syncytial virus (RSV), human metapneumovirus, adenovirus, human parainfluenza viruses, ... Viral infections weaken the immune system, making the body more susceptible to bacterial infection (including bacterial ... The most common viruses are influenza, parainfluenza, human respiratory syncytial virus, human metapneumovirus and adenovirus. ... Typically, a virus enters the lungs through the inhalation of water droplets and invades the cells lining the airways and the ...

*Rhinitis

... human parainfluenza viruses, human respiratory syncytial virus, enteroviruses other than rhinoviruses, metapneumovirus, and ... In the case of infectious rhinitis, it may occasionally lead to pneumonia, either viral or bacterial. Sneezing also occurs in ... Rhinitis is commonly caused by a viral or bacterial infection, including the common cold, which is caused by Rhinoviruses, ... Human Molecular Genetics. 18 (3): 580-593. doi:10.1093/hmg/ddn372. PMC 2722191 . PMID 18996923. CS1 maint: Explicit use of et ...

*Transmission (medicine)

... parainfluenza virus, adenovirus, respiratory syncytial virus, human metapneumovirus), Bordetella pertussis, pneumococci, ... Biological vectors are often responsible for serious blood-borne diseases, such as malaria, viral encephalitis, Chagas disease ... Human aggregation can drive transmission, seasonal variation and outbreaks of infectious diseases, such as the annual start of ... It is also responsible for the increased incidence of herpes simplex virus 1 (which is usually responsible for oral infections ...

*Common cold

... human parainfluenza viruses, and metapneumovirus. Frequently more than one virus is present. In total over 200 viral types are ... Human parainfluenza virus typically results in inflammation of the nose, throat, and bronchi. In young children when it affects ... Isolation of the viral agent involved is rarely performed, and it is generally not possible to identify the virus type through ... Other commonly implicated viruses include human coronavirus (≈ 15%),influenza viruses (10-15%), adenoviruses (5%), human ...

*Taxonomic list of viruses

Bovine parainfluenza virus 3 Human parainfluenza virus 1 Human parainfluenza virus 3 Sendai virus Simian virus 10 Genus: ... Metapneumovirus Avian metapneumovirus Human metapneumovirus Genus: Pneumovirus Bovine respiratory syncytial virus Human ... Border disease virus Bovine viral diarrhea virus 1 Bovine viral diarrhea virus 2 Classical swine fever virus Family: ... virus Shuni virus Simbu virus Tacaiuma virus Tete virus Thimiri virus Timboteua virus Turlock virus Wyeomyia virus Zegla virus ...

*Transporter Classification Database

1.A.40 Human immunodeficiency virus type I Vpu channel family 1.A.41 Avian reovirus p10 Vvroporin family 1.A.42 HIV viral ... Family 1.A.103 The Simian Virus 5 (Parainfluenza Virus 5) SH (SV5-SH) Family 1.A.104 The Proposed Flagellar Biosynthesis Na+ ... Family 1.A.89 The Human Coronavirus 229E Viroporin (229E Viroporin) Family 1.A.90 The Human Metapneumovirus (HMPV) Viroporin ( ... Family 1.G.21 The Epstein Barr Virus (Human Herpes Virus 4) Gp42 (Gp42) Family 1.G.22 The Cytomegalovirus (Human Herpesvirus 5 ...

*List of virus species

E Human mastadenovirus F Human mastadenovirus G Human metapneumovirus Human parainfluenza virus 1 Human parainfluenza virus 2 ... Bovine rhinitis A virus Bovine rhinitis B virus Bovine torovirus Bovine viral diarrhea virus 1 Bovine viral diarrhea virus 2 ... Human parainfluenza virus 3 Human parainfluenza virus 4 Human picobirnavirus Human polyomavirus 1 Human polyomavirus 2 Human ... virus A Potato virus H Potato virus M Potato virus P Potato virus S Potato virus T Potato virus U Potato virus V Potato virus X ...

*List of MeSH codes (B04)

... parainfluenza virus 1, human MeSH B04.820.455.600.650.700.735 --- parainfluenza virus 3, human MeSH B04.820.455.600.650.700.800 ... bovine viral MeSH B04.820.250.700.150.100 --- diarrhea virus 1, bovine viral MeSH B04.820.250.700.150.120 --- diarrhea virus 2 ... simian virus 5 MeSH B04.820.455.600.670 --- pneumovirinae MeSH B04.820.455.600.670.500 --- metapneumovirus MeSH B04.820.455.600 ... parainfluenza virus 1, human MeSH B04.909.777.455.600.650.700.735 --- parainfluenza virus 3, human MeSH B04.909.777.455.600.650 ...
Human metapneumovirus (hMPV) is an important cause of lower respiratory tract infections in hospitalized children, but the age-related incidence and effect of hMPV in unselected children in the community have not been evaluated. We studied a cohort of 1,338 children <13 years of age throughout 1 respiratory season in Finland during 2000-2001. We examined children and obtained a nasal swab for viral detection at any sign of respiratory infection. hMPV was detected in 47 (3.5%) of the 1,338 children. The age-related incidence of hMPV infection was highest (7.6%) in children <2 years of age, in whom hMPV accounted for 1.7% of all infections during the season. During the epidemic peak, hMPV caused 7.1% of all respiratory infections in the cohort. Acute otitis media developed in 61% of hMPV-infected children <3 years of age. Our findings demonstrate that the effect of hMPV in the community is greatest in ...
Lung dendritic cells (DC) play a fundamental role in sensing invading pathogens, as well as in the control of tolerogenic responses in the respiratory tract. Their strategic localization at the site of pathogen entry makes them particularly susceptible to initial viral invasion. Human respiratory syncytial virus (hRSV) and human metapneumovirus (hMPV) belong to the Paramyxoviridae family, within the Pneumovirus and Metapneumovirus genera, respectively. hRSV and hMPV are significant human respiratory pathogens that cause similar clinical manifestations and affect many of the same subpopulations. However, they differentially activate the host immune response, including DC, which represents a fundamental link between the innate and adaptive immune response. In this review, the role of DC in the ...
Avian metapneumovirus causes acute respiratory tract infection and reductions in egg production in various avian species. We isolated and characterized an increasingly prevalent avian metapneumovirus subgroup C strain from meat-type commercial chicke
Human metapneumovirus (HMPV) is a leading cause of respiratory infection that causes upper airway and severe lower respiratory tract infections. HMPV infection is initiated by viral surface glycoproteins that attach to cellular receptors and mediate virus membrane fusion with cellular membranes. Most paramyxoviruses use two viral glycoproteins to facilitate virus entry-an attachment protein and a fusion (F) protein. However, membrane fusion for the human paramyxoviruses in the Pneumovirus subfamily, HMPV and respiratory syncytial virus (hRSV), is unique in that the F protein drives fusion in the absence of a separate viral attachment protein. Thus, pneumovirus F proteins can perform the necessary functions for virus entry, ...
HMPV is a viral respiratory pathogen that was discovered in 2001, but studies have shown that it has been circulating in humans for at least 50 years. Older adults and adults with asthma who are infected with HMPV may be at increased risk for lower respiratory illness and hospitalization. In infants and young children, HMPV infection may cause upper or lower respiratory illness, ear infections, bronchiolitis, croup, pneumonia, and exacerbations of asthma. Children less than 2 years of age are most susceptible to severe HMPV infections, and HMPV is the second or third leading cause of viral lower respiratory illness in children. The National Institute of Allergy and Infectious Diseases (NIAID) is working to develop a live-attenuated, intranasally administered HMPV vaccine for use in infants. The purpose of this study is to evaluate the safety and immunogenicity of an HMPV vaccine.. The vaccine will be evaluated in four groups of participants: ...
HMPV is a viral respiratory pathogen that was discovered in 2001, but studies have shown that it has been circulating in humans for at least 50 years. Older adults and adults with asthma who are infected with HMPV may be at increased risk for lower respiratory illness and hospitalization. In infants and young children, HMPV infection may cause upper or lower respiratory illness, ear infections, bronchiolitis, croup, pneumonia, and exacerbations of asthma. Children less than 2 years of age are most susceptible to severe HMPV infections, and HMPV is the second or third leading cause of viral lower respiratory illness in children. The National Institute of Allergy and Infectious Diseases (NIAID) is working to develop a live-attenuated, intranasally administered HMPV vaccine for use in infants. The purpose of this study is to evaluate the safety and immunogenicity of an HMPV vaccine.. The vaccine will be evaluated in four groups of participants: ...
Human metapneumovirus (HMPV) is a member of the subfamily Pneumovirinae within the family Paramyxoviridae. Other members of this subfamily, respiratory syncytial virus and avian pneumovirus, can be divided into subgroups based on genetic or antigenic differences or both. For HMPV, the existence of different genetic lineages has been described on the basis of variation in a limited set of available sequences. We address the antigenic relationship between genetic lineages in virus neutralization assays. In addition, we analyzed the genetic diversity of HMPV by phylogenetic analysis of sequences obtained for part of the fusion protein (n = 84) and the complete attachment protein open reading frames (n = 35). On the basis of sequence diversity between attachment protein genes and the differences in virus neutralization titers, two HMPV serotypes were defined. Each serotype could ...
RSV and hMPV infection modulates ARE-dependent gene transcription(A) A549 cells were transiently transfected with a plasmid containing multiple copies of the NQ
Research in the area of immunology in the department focuses on the response of the immune system to bacterial, parasitic and viral pathogens. Topics of research interest in this area include evasion of the immune response and persistence, molecular mechanisms underlying inflammatory responses and vaccine development for a variety of microbial pathogens. Specific research programs include: vaccine design for Brucella Abortus, West Nile Virus, Dengue Virus, Herpes viruses and Bovine Coronavirus and Herpesvirus Type-1. The lymphocyte-mediated response to Bartonella and nematode infection, the analysis of the innate and adaptive immune response to respiratory syncytial virus and human metapneumovirus infections, as well as the study of the innate immune/inflammatory response in the lung to bacterial infection are also ...
Y. Fu, I. Lee, Y. S. Lee and X. Bao. Small Non-coding Transfer RNA-derived RNA Fragments (tRFs): Their Biogenesis, Function and Implication in Human Diseases. Genomics & Informatics 13, 94-101 (2015).. D. Junfang, R. N. Ptashkin, Q. Wang, G. Liu, G. Zhang, I. Lee, Y. S. Lee, and X. Bao. Human Metapneumovirus Infection Induces Significant Changes in Small Noncoding RNA Expression in Airway Epithelial Cells. Molecular Therapy Nucleic Acids 3, e163 (2014).. N. H. Kim, Y. H. Cha, S. E. Kang, Y. M. Lee, I. Lee, S. Y. Cha, J. K. Ryu, J. M. Na, C. Park, H.-G. Yoon, J. I. Yook, and H. S. Kim. p53 regulates nuclear GSK-3 levels through miR-34-mediated Axin2 suppression in colorectal cancer cells. Cell Cycle 12, 1578-1587 (2013).. B. Gong, Y. S. Lee, I. Lee, T. R. Shelite, N. Kunkeaw, G. Xu, K. Lee, S. H. Jeon, B. H. Johnson, Q. Chang, T. Ha, N. L. Mendell, X. Cheng, D. H. Bouyer, P. J. Boor, T. G. Ksiazek, D. H. ...
Twelve specific pathogen-free (SPF) puppies were vaccinated intranasally with a bivalent, modified live vaccine against infectious tracheobronchitis (group 1) and six puppies of the same age and from the same source served as unvaccinated controls (group 2). Both groups were challenged with wild-type Bordetella bronchiseptica and canine parainfluenza virus by the aerosol route 56 weeks after group 1 had been vaccinated, and at the same time six 10-week-old SPF puppies from the same source (group 3) were also challenged. Oronasal swabs were taken regularly before and after the challenge, for the isolation of bacteria and viruses, and the dogs were observed for clinical signs for three weeks after the challenge. The control dogs became culture-positive for B bronchiseptica and canine parainfluenza virus, but the isolation yields from the vaccinated group were significantly lower (P,0·05). The mean clinical scores of the ...
veterinary pathologist with the UC Davis Mountain Gorilla One Health Program who has studied gorilla diseases for more than 25 years.. The two gorillas described in the new study were members of the Hirwa group living in Rwanda. In 2008 and 2009, this group experienced outbreaks of respiratory disease, with various amounts of coughing, eye and nose discharge, and lethargy. In the 2009 outbreak, the Hirwa group consisted of 12 animals: one adult male, six adult females, three juveniles and two infants. All but one were sick. Two died: an adult female and a newborn infant.. Tissue analyses showed the biochemical signature of an RNA virus called human metapneumovirus (HMPV) infecting both animals that had died. While the adult female gorilla ultimately died as a result of a secondary bacterial pneumonia infection, HMPV infection likely predisposed her to pneumonia. HMPV was also found in the infant gorilla, which was born to a ...
Slater, O.M., Terio, K.A., Zhang, Y., Erdman, D.D., Schneider, E., Kuypers J.M., Wolinsky, S.M., Kunstman, K.J., Kunstman, J., Kinsel, M.J., and Gamble, K.C. 2014. Human Metapneumovirus Infection in Chimpanzees, United States. Emerging Infectious Diseases, 20(12), 2115-2118. Ségurel, L, EE Thompson, T Flutre, J Lovstad, A Venkat, SW Margulis, J Moyse, SR Ross, K Gamble, G Sella, C Ober, M Przeworski. 2012. The ABO blood group is a trans-species polymorphism in primates. Proceedings of the National Academy of Sciences, 109 (45) 18493-18498.
Chemistry BS: University of Central Arkansas - 2006. Molecular and Cellualr Biochemistry PhD: University of Kentucky College of Medicine - 2012. PhD Dissertation Project Title: "Early Events of Human Metapneumovirus Infection". MD: University of Kentucky College of Medicine - 2014. Current: Internal Medicine Resident: Emory University School of Medicine - Alanta, GA ...
NIH Rare Diseases : 53 Parainfluenza virus type 3 is one of a group of common viruses known as human parainfluenza viruses (HPIV) that cause a variety of respiratory illnesses. Symptoms usually develop between 2 and 7 days from the time of exposure and typically resolve in 7-10 days. Symptoms may include fever, runny nose, and cough. HPIV-3 can also cause bronchiolitis, bronchitis, and pneumonia. Infants and young children are particularly susceptible to HPIV-3 infections, though older adults and those with a weakened immune system are also at risk for complications. HPIVs are usually spread from an infected person to others through coughing, sneezing, and/or touching. There is currently no vaccine to protect against parainfluenza virus infections. Most HPIV infections resolve on their own and do not require special treatment, though medical intervention may ...
Krish was awarded Ph.D. in Life Sciences from Jadavpur University, Kolkata, India in 2010. During his doctoral research he studied cancer mediated Immunosuppression and role of Neem leaf glycoprotein (NLGP) and Interferon alpha 2b as an immune modulator in the maintenance of immune homeostasis during head and neck squamous cell carcinoma (HNSCC). After finishing his doctoral thesis I joined Dept. of Pathobiological Sciences, Louisiana State University, USA and pursued his further research in the field of viral immunology. As a postdoctoral researcher he studied the role of immune modulatory cytokines in human metapneumo virus (hMPV) infection model. Presently he is working as a postdoctoral scientist in the Dept. of Lymphocyte Signalling Lab and Development, Babraham Institute, Cambridge, UK. His current interest is to determine the role of Phosphokinases and RNA binding proteins in Influenza virus infection.. ...
Objective: To investigate the prevalence of 14 viruses in infants with bronchiolitis and to study demographic and clinical differences in those with respiratory syncytial virus (RSV), human bocavirus (hBoV) and rhinovirus (RV) infection.. Methods: 182 infants aged ,12 months hospitalised for bronchiolitis were enrolled. Infants underwent nasal washing for the detection of RSV, influenza virus A and B, human coronavirus OC43, 229E, NL-63, HUK1, adenovirus, RV, parainfluenza 1-3, human metapneumovirus and hBoV. Demographic, clinical and laboratory data were obtained from parents and from patient medical files. Main outcome measurements were age, breastfeeding history, family smoking habits, family history for asthma and atopy, blood eosinophil ...
This project is concerned with how the recently discovered paramyxovirus, human metapneumovirus (HMPV), interacts with host cells to initiate entry. In this dissertation I explore whether the HMPV fusion protein interacts with cellular proteins during virus attachment and whether receptor binding is sufficient to initiate virus-mediated fusion at the cell surface. In this research I developed novel techniques to study HMPV fusion and entry. I learned that the HMPV fusion protein uses RGD-binding integrins to mediate attachment and virus entry, binding to integrins is not sufficient to trigger HMPV fusion, and HMPV fuses with intracellular membranes instead of at the cell surface. In sum, I have elucidated mechanisms that HMPV utilizes to mediate virus entry, which are unique from the entry mechanism used by other paramyxoviruses ...
Human metapneumovirus is related to the respiratory syncytial virus, measles, mumps and parainfluenza viruses. It infects people of all ages but is most common in children under five. Symptoms include runny nose, cough, sore throat and fever. Infection can also lead to more severe illnesses such as bronchitis and pneumonia, which can result in hospitalisation, especially in infants and immunocompromised patients. HMPV infection is most common during the winter and it is believed to cause up to 10% of respiratory illnesses in children ...
Human metapneumovirus (hMPV) is a respiratory virus detected in ≥9% of allogeneic hematopoietic stem cell transplant (HSCT) recipients, in whom it can cause significant morbidity and mortality. Given the lack of effective antivirals, we investigated the potential for immunotherapeutic intervention, using adoptively transferred T cells. Thus, we characterized the cellular immune response to the virus and identified F, N, M2-1, M, and P as immunodominant target antigens. Reactive T cells were polyclonal (ie, they expressed CD4 and CD8), T-helper type 1 polarized, and polyfunctional (ie, they produced interferon γ, tumor necrosis factor α, granulocyte-macrophage colony-stimulating factor, and granzyme B), and they were able to kill autologous antigen-loaded targets ...
Our only Christmas together was spent in the hospital. Sully had human metapneumovirus, hMPV. It was a nasty, scary respiratory virus that landed us at Carle for 3 days. The Dr surprised us by releasing us on Christmas night. We had been told it would be another day or 2. She said he needed to stay home for the entire following week. So, I ended up being home with him the week between Christmas and New Years. This was a gift. He only lived 11 days into the new year. Ill post a few pics in a minute ...
Achoo!. Feel like a sneeze or cough coming on? Cover it in a cloth or tissue paper, or even your sleeves, and wash your hands, admonishes the Centers for Disease Control and Prevention (CDC) - and for good reasons, too! Microbial pathogenic agents of a variety of respiratory illnesses, both viral [ranging from the common cold (rhinovirus); influenza (orthomyxovirus); parainfluenza viruses, respiratory syncytial virus (RSV), and human metapneumovirus (all paramyxoviruses); severe acute respiratory syndrome (SARS-Coronavirus)] as well as bacterial [such as those responsible for pneumonia (Streptococcus pneumoniae), whooping cough (Bordetella pertussis), and tuberculosis (Mycobacterium tuberculosis)] are often transmitted by cough, sneeze, and/or unclean hands/palms carrying these germs on their surfaces.. ...
Achoo!. Feel like a sneeze or cough coming on? Cover it in a cloth or tissue paper, or even your sleeves, and wash your hands, admonishes the Centers for Disease Control and Prevention (CDC) - and for good reasons, too! Microbial pathogenic agents of a variety of respiratory illnesses, both viral [ranging from the common cold (rhinovirus); influenza (orthomyxovirus); parainfluenza viruses, respiratory syncytial virus (RSV), and human metapneumovirus (all paramyxoviruses); severe acute respiratory syndrome (SARS-Coronavirus)] as well as bacterial [such as those responsible for pneumonia (Streptococcus pneumoniae), whooping cough (Bordetella pertussis), and tuberculosis (Mycobacterium tuberculosis)] are often transmitted by cough, sneeze, and/or unclean hands/palms carrying these germs on their surfaces.. ...
Lancet. "…….Between Aug 15, 2011, and Jan 30, 2014, we enrolled 4232 cases and 5119 community controls. The primary analysis group was comprised of 1769 (41·8% of 4232) cases without HIV infection and with positive chest x-rays and 5102 (99·7% of 5119) community controls without HIV infection.. Wheezing was present in 555 (31·7%) of 1752 cases (range by site 10·6-97·3%).. 30-day case-fatality ratio was 6·4% (114 of 1769 cases).. Blood cultures were positive in 56 (3·2%) of 1749 cases, and Streptococcus pneumoniae was the most common bacteria isolated (19 [33·9%] of 56). Almost all cases (98·9%) and controls (98·0%) had at least one pathogen detected by PCR in the NP-OP specimen. The detection of respiratory syncytial virus (RSV), parainfluenza virus, human metapneumovirus, influenza virus, S pneumoniae, Haemophilus influenzae type b (Hib), H influenzae non-type b, and ...
B. pertussis, the organism that causes pertussis, elaborates multiple toxins, including tracheal cytotoxin, which damages the respiratory epithelial tissue in vitro (24), and pertussis toxin, which has systemic effects (e.g., promoting lymphocytosis) (25). Illnesses caused by other species of Bordetella are not considered preventable by available pertussis vaccines (26,27). Clinical Features B. pertussis infections and reinfections among adults and adolescents can be asymptomatic or range from a mild cough illness to the severe, prolonged cough illness of classic pertussis (28). The clinical presentation of pertussis can be similar to that for respiratory illness caused by B. parapertussis, B. bronchiseptica, B. holmseii, Mycoplasma pneumoniae, Chlamydia (Chlamydophila) pneumoniae, and multiple viral agents (e.g., adenovirus, parainfluenza virus, human metapneumovirus, ...
Wyde, P. R., Moylett, E. H., Chetty, S. N., Jewell, A., Bowlin, T. L. and Piedra, P. A. (2004) Comparison of the Inhibition of Human Metapneumovirus and Respiratory Syncytial Virus by NMSO3 in Tissue Culture Assays. Antiviral Research, 63 :51-59 [Details] ...
SARS is a condition associated with substantial morbidity and mortality. It appears to be of viral origin, with patterns suggesting droplet or contact transmission. The role of human metapneumovirus, a novel coronavirus, or both requires further investigation.
Why was this study done? This study was designed to help understand the progression of parainfluenza infection for the development of potential anti-viral strategies.. What did the study find?. The study suggested that the most direct strategy for preventing infection may be by interfering with the initial receptor binding of the virus to the host cell.. ...
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Respiratory viral infections can cause severe pneumonia in lung transplant recipients as well are associated with acute rejection and long-term morbidity with bronchiolitis obliterans syndrome. There are no specific antiviral options for the majority of respiratory viruses. DAS181 is a novel sialidase fusion protein and is administered by inhalation. The authors describe the use of this new antiviral in a lung transplant patient with parainfluenza virus infection requiring ICU admission. The authors obtained this drug under an emergency investigational new drug application. The case report describes clinical and virologic improvement with use of this medication, which was also well-tolerated. Newer therapies for respiratory virus infections are a welcome addition especially for transplant patients where disease is severe and options are limited.. ...
GONZALES, Ralph et al. Antibiotic knowledge and self-care for acute respiratory tract infections in Mexico. Salud pública Méx [online]. 2012, vol.54, n.2, pp.152-157. ISSN 0036-3634.. OBJECTIVE: To examine knowledge of and self-treatment with antibiotics among medically-insured adults in Mexico. MATERIALS AND METHODS: We conducted a cross-sectional, interviewer-administered survey among 101 adult patients seeking care for acute respiratory tract infections in a family medicine clinic in Mexico. Knowledge scores were calculated as a composite of correct, incorrect and dont know responses. Factors associated with antibiotic knowledge and antibiotic self-treatment were explored with bivariate analyses. RESULTS: 47% of participants were taking antibiotics prior to the visit, 20% were self-treating. Antibiotic knowledge was highly variable. Many participants believed common non-antibiotic treatments for colds and coughs were antibiotics, such as ambroxol (45%), Desenfriol (45%) and paracetamol ...
... | Clone: B3291M | Application: ELISA, IF, IA | Species reactivity: | Alias: Monoclonal Antibody to Parainfluenza Type 3, Hemagglutinin
... , Nobivac Canine is for the vaccination of healthy dogs as an aid in prevention of infectious disease associated with canine adenovirus type 2, canine parainfluenza virus,
Background: Human Parainfluenza viruses are a common cause of both upper and lower respiratory tract infections, particularly in children. Of the four Parainfluenza virus serotypes, Parainfluenza 4 is least well characterised from both the clinical, epidemiological and genetic perspectives. Methods: Flocked nose or throat swabs from a previous study investigating viral prevalence in community-based adults suffering from influenza like illness were used as the basis for this study. Samples in which no virus was detected using a 16 viral respiratory pathogen real-time PCR panel were barcoded and pyrosequenced using the Roche 454 GS FLX Titanium chemistry. The sequences were analysed using the VirusHunter bioinformatic pipeline. Sanger sequencing was used to complete the detected Parainfluenza 4 coding region. ...
Pneumoviridae (from Greek pneumo-, lung, -viridae, virus from Latin, poison, slimy liquid) is a new virus family in the order Mononegavirales. It was created in 2016 by elevating the now dissolved paramyxoviral subfamily Pneumovirinae. Natural hosts include humans, cattle, and rodents. There are currently 5 species in the Pneumoviridae family, divided between 2 genera (Metapneumovirus and Orthopneumovirus). Pneumoviruses are pleomorphic, capable of producing spherical and filamentous enveloped virions (virus particles) that vary in size from 150 to 200 nm in diameter. The nucleocapsid consisting of a protein shell and viral nucleic acids has a helical symmetry. Nucleocapsids have a diameter of 13.5 nm and a helical pitch of 6.5 nm. The genome is composed of negative-sense single-stranded RNA that is ...
Define lower respiratory infection. lower respiratory infection synonyms, lower respiratory infection pronunciation, lower respiratory infection translation, English dictionary definition of lower respiratory infection. Noun 1. lower respiratory infection - infection of the lower respiratory tract respiratory infection, respiratory tract infection - any infection of the...
HMPVs and RSVs are major contributors to respiratory tract infections in infants and young children. In most infants, these viruses cause symptoms resembling those of the common cold. However, in infants born prematurely, children with chronic lung disease, or children with congenital heart disease, these viruses can result in a severe or even life-threatening disease. As many as 125,000 hospitalizations occur annually in children ,1 y old due to lower respiratory infection or bronchiolitis (46). Developing new therapeutics to prevent and treat these infections is therefore of considerable importance.. Limiting virus infection requires rapidly mounted defenses, which include in large part the release of type I IFN (IFN-α/β). IFN limits viral replication directly and enhances viral clearance by activating adaptive immunity. Understanding how viruses are sensed and how type I IFN is regulated may facilitate ...
We performed a general survey on pathogens responsible for respiratory infectious diseases at a recruit training site for the first time. To improve the data quality, we selected commercial kits for preliminary screening. The results showed that the pathogen carrier rate in recruits without respiratory symptoms was very low, and among 795 nasopharyngeal swab samples, only two were adenovirus-positive; they were identified as group C type 1 adenovirus with low virulence.. During the 3 months of training, 5 cases of adenovirus were detected among 39 recruits with fever and respiratory symptoms, indicating that adenovirus is the major causal pathogen for respiratory infectious disease at recruit training sites. According to retrospective studies on respiratory infections in troops during the past 25 years in the USA, the most common ARDs pathogens in troops are adenovirus, influenza (parainfluenza) ...
Parainfluenza virus is the second most common cause of lower respiratory disease in young children. Parainfluenza virus can cause respiratory tract illness in patients of any age.
Research in Virology and Veterinary Virology are based in new laboratories at three sites, the Ronald Ross Building, IC2 and Leahurst. They encompass studies of the pathogenicity, diagnostics, identification, epidemiology and immune responses to a range of viral pathogens including: Japanese encephalitis virus,HIV,respiratory syncytial virus, cytomegalovirus and other herpesviruses, chicken metapneumovirus, feline calicivirus and Schmallenberg virus. Techniques used include: diagnostic identification methods, flow cytometry, ELISA, epidemiology, PCR and transcriptomic and genomic technologies, including metagenomics, resequencing and genotyping cell separation, proteomics and infection models.. The aims of the research are to investigate the transmission routes and behaviour of pathogens during infections and use this knowledge to design better therapeutic ...
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Acute respiratory tract infections (ARTIs) are associated with significant morbidity and mortality worldwide, especially in children under the age of 5 years. Almost 2 million children die from ARTIs each year, and most of them are from developing countries. The prevalence and correlation of pathogens in ARTIs are poorly understood, but are critical for improving case prevention, treatment, and management. In this study, we investigated the prevalence and correlation of infectious agents in children with ARTIs. A total of 39,756 children with one or more symptoms, including fever, cough, sore throat, tonsillitis, pharyngitis, herpangina, pneumonia, and bronchiolitis, were enrolled in the study. All patients were hospitalized in Wuhan Childrens Hospital between October 1, 2010 and September 30, 2012, and were evaluated for infectious agents. Pathogens, including Mycoplasma pneumoniae, influenza A virus, influenza B virus, adenoviruses, respiratory syncytial ...
Research in Immunology is based in new laboratories at three sites, the Ronald Ross Building, IC2 and Leahurst. It encompasses studies of the immune responses to and vaccination against a range of bacterial, viral and parasitic pathogens including: Streptococcus pneumoniae, Mycobacterium tuberculosis, Japanese encephalitis virus,HIV,cytomegalovirus and other herpesviruses, chicken metapneumovirus, Salmonella, Treponema, Onchocerca, Fasciola, cyathostomins, Cryptosporidium, Giardia, Toxoplasma and Neospora caninum. Techniques used include: tissue and pathogen culture, cell separation, flow cytometry, proliferation assays, ELISA, antibody production, Western blotting, proteomics, PCR and transcriptomic and genomic technologies, including metagenomics, resequencing and genotyping.. The aims of the research are to investigate the nature of the cellular and humoral immune responses to pathogens of ...
... is the first journal to specialise exclusively on influenza and other respiratory viruses and strives to play a key role in the disemmination of information in this broad and challenging field. It is aimed at laboratory and clinical scientists, public health professionals, and others around the world involved in a broad range of activities in this field. In turn, topics covered will include: - surveillance - epidemiology - prevention by vaccines - prevention and treatment by antivirals - clinical studies public health & pandemic preparedness basic scientific research transmission between animals and humans (source ...
According to the new study recently published in the Journal of the American Medical Association (JAMA), for children with acute respiratory tract infections, the broad-spectrum antibiotics are not associated with better clinical or patient-centered outcomes compared with narrow-spectrum antibiotics, and the narrower-targeting drugs are associated with higher rates of adverse events. Acute respiratory infections such as ear infections, sinus infections, and streptococcal pharyngitis (sore throat) account for most bacterial respiratory infections in children and are the primary drivers of pediatric antibiotic prescribing ...
Description of disease Upper Respiratory Tract Infection. Treatment Upper Respiratory Tract Infection. Symptoms and causes Upper Respiratory Tract Infection Prophylaxis Upper Respiratory Tract Infection
Thirteen colostrum deprived calves were inoculated with a low passage field strain of parainfluenza type III (PI 3) virus. Virus was administered by the intranasal route and the calves were experimentally infected twice daily for four consecutive days. Clinical signs of respiratory disease were noted and pneumonia was present in 12 animals at necropsy. PI 3 virus was isolated from the lung lesions and no other respiratory pathogens could be demonstrated. The pneumonic lesions grossly, histologically and in their distribution resembled those encountered in naturally occurring outbreaks of indoor calf pneumonia.. ...
Antibiotic use for acute respiratory tract infections that are largely viral remains common. Macrolide use has increased since 2007, and 9% of patients received a second antibiotic within 30 days.
Boivin G, Abed Y, Pelletier G, Ruel L, Moisan D, Côté S, Peret TC, Erdman DD, Anderson LJ (2002). "Virological features and clinical manifestations associated with human metapneumovirus: a new paramyxovirus responsible for acute respiratory-tract infections in all age groups". J. Infect. Dis. 186 (9): 1330-4. PMID 12402203. doi:10.1086/344319 ...
RSV causes acute respiratory tract illness in persons of all ages. Traditionally a viral pathogen of children, RSV can cause CAP in adults that could be particularly severe in older adults and immunocompromised individuals with a mortality rate similar to influenza-attributable mortality.33 Clinical features are not distinct from other causes of viral pneumonia. Patients usually present with symptoms of upper respiratory tract infection followed by pneumonia. Wheezing is a common feature in RSV pneumonia.34 Among HSCT recipients and patients with hematological malignancy, RSV is a significant cause of pneumonia. Risk of progression to pneumonia ranged from 18 to 55 per cent.15 Pneumonia and mortality rates are higher when RSV is contracted in the first few months after HSCT; other risk factors include presence of graft versus host disease, increasing age, and myeloablative conditioning.15 21 35 RSV infection is associated with decrease in pulmonary function tests and ...
Genomic fragments of the HN and L genes from Brazilian bovine parainfluenza 3 virus (bPIV-3) isolated as contaminants from cell cultures and clinical specimens were amplified by reverse transcription-polymerase chain reaction (RT-PCR), sequenced using specific degenerate primers and analyzed by phylogenetic comparison with reference strains of bPI3V. The Brazilian isolates revealed a high degree of genomic when compared to SF4/32 prototype strain, within the recently proposed genotype A of bPIV-3 ...
The innate immune system is the first line of host defense and against viral pathogens via effector molecules, such as type-I interferon (IFN-α/β). Plasmacytoid dendritic cells (pDC) and monocyte-derived DC (moDC) are potent producers of IFN in response to viruses through the respective activation of recognition toll-like receptors (TLRs) and cytosolic RNA helicases MDA5 and RIG-I. Exposure to environmental tobacco smoke (ETS) is a risk factor associated with an increase in the frequency and severity of respiratory infections. However, the mechanisms by which ETS alters innate immune responses have not been fully elucidated. Therefore, we investigated the ability of pDC and moDC to respond to respiratory syncytial virus (RSV) and human metapneumovirus (hMPV) in the presence of cigarette smoke extract (CSE). In viral infected pDC and moDC, CSE led to a significant ...
The study aim was to investigate the prevalence and clinical relevance of viral findings by multiplex PCR from the nasopharynx of clinically septic patients during a winter season. During 11 weeks of the influenza epidemic period in January-March 2012, consecutive adult patients suspected to be septic (n = 432) were analyzed with cultures from blood and nasopharynx plus multiplex PCR for respiratory viruses on the nasopharyngeal specimen. The results were compared with those from microbiology analyses ordered as part of standard care. During the winter season, viral respiratory pathogens, mainly influenza A virus, human metapneumovirus, coronavirus, and respiratory syncytial virus were clinically underdiagnosed in 70% of patients positive by the multiplex PCR assay. During the first four weeks of the influenza epidemic, few tests for ...
SAN DIEGO, May 28, 2019 /PRNewswire/ - Ansun Biopharma, Inc., today announced that the first patient has been enrolled in its Phase 3 clinical trial evaluating the efficacy and safety of DAS181 for the treatment of hospitalized, immunocompromised patients with lower respiratory tract parainfluenza virus infection. The Phase 3 clinical trial (STOP PIV) is being conducted in multiple study centers throughout the U.S., Europe and Asia. "Parainfluenza infection in normal, healthy patients is not a life-threatening disease. But in hospitalized, immunocompromised patients who are trying to recover from cancer or an organ transplant, for example, it can cause respiratory complications that may be deadly or cause permanent damage to the lungs, and is an area of unmet medical need," stated Dr. Stanley Lewis, Ansuns Chief Medical Officer. There are no approved drugs to treat parainfluenza infection, making DAS181 a potentially first-in-class ...
INTRODUCTION: Pneumonia in children is a common disease yet determining its aetiology remains elusive.. OBJECTIVES: To determine the a) aetiology, b) factors associated with bacterial pneumonia and c) association between co-infections (bacteria + virus) and severity of disease, in children admitted with severe pneumonia.. METHODS: A prospective cohort study involving children aged 1-month to 5-years admitted with very severe pneumonia, as per the WHO definition, over 2 years. Induced sputum and blood obtained within 24 hrs of admission were examined via PCR, immunofluorescence and culture to detect 17 bacteria/viruses. A designated radiologist read the chest radiographs.. RESULTS: Three hundred patients with a mean (SD) age of 14 (±15) months old were recruited. Significant pathogens were detected in 62% of patients (n = 186). Viruses alone were detected in 23.7% (n = 71) with rhinovirus (31%), human ...
Abortion-induced sepsis can progress unnoticed if subtle abnormalities of platelet function defects nonpalpable purpura drugs eg, cyclosporin a by viruses include viagra powered burning book by site astroviruses, corona-like viruses, and respiratory syncytial virus rsv, human metapneumovirus, cannot be used to measure the generation of cardiac symptoms is not a true burn, and the clinical manifestations of migraine. Semin pediatr neurol. Hodgkin disease is unknown. Red cells have difficulty forming relationships with patients who are unable to feed, provide intravenous glucose should be iced and compression applied. Patients should be corrected surgically because of movement in the chart in an organ as blood is called atelectasis. _ch . pm page unit iii integrated control and adjusting therapy or by intravenous bolus. One vial of antitoxin should be determined in case of ...
Matrix metalloproteinases (MMPs) play an important role in respiratory inflammatory diseases, such as asthma and chronic obstructive pulmonary disease. It was hypothesized that MMP-8 and MMP-9 may function as biological markers to assess disease severity in viral lower respiratory tract infections in children. MMP-8 and MMP-9 mRNA expression levels in peripheral blood mononuclear cells (PBMCs) and granulocytes obtained in both the acute and recovery phase from 153 children with mild, moderate, and severe viral lower respiratory tract infections were determined using real-time PCR. In addition, MMP-8 and MMP-9 concentrations in blood and nasopharyngeal specimens were determined during acute mild, moderate, and severe infection, and after recovery using ELISA. Furthermore, PBMCs and neutrophils obtained from healthy volunteers were stimulated with RSV, LPS (TLR4 agonist), and Pam3Cys (TLR2 agonist) in vitro. Disease severity of viral lower respiratory tract ...
Definition : Serology reagents intended to detect immunoglobulin G (IgG) antibodies to Parainfluenza type 3 virus, a single-stranded RNA virus of the genus Paramyxovirus, family Paramyxoviridae. This virus is an etiologic agent of parainfluenza and several upper respiratory tract infections (e.g., bronchitis, pneumonia) of varying severity.. Entry Terms : "Reagents, Serology, Virus, Parainfluenza 3, IgG Antibody". UMDC code : 22424 ...
TY - JOUR. T1 - High Human Bocavirus Viral Load Is Associated with Disease Severity in Children under Five Years of Age. AU - Zhao, Baihui. AU - Yu, Xuelian. AU - Wang, Chuanxian. AU - Teng, Zheng. AU - Wang, Chun. AU - Shen, Jiaren. AU - Gao, Ye. AU - Zhu, Zhaokui. AU - Wang, Jiayu. AU - Yuan, Zhengan. AU - Wu, Fan. AU - Zhang, Xi. AU - GHILDYAL, Reena. PY - 2013/4/30. Y1 - 2013/4/30. N2 - Human bocavirus (HBoV) is a parvovirus and detected worldwide in lower respiratory tract infections (LRTIs), but its pathogenic role in respiratory illness is still debatable due to high incidence of co-infection with other respiratory viruses. To determine the prevalence of HBoV infection in patients with LRTI in Shanghai and its correlation with disease severity, we performed a 3-year prospective study of HBoV in healthy controls, outpatients and inpatients under five ...
There are plenty of respiratory diseases that can affect dogs, caused by both viruses and bacteria. Canine parainfluenza is a viral disease. Another not usually a life-threatening illness, most dogs are vaccinated against it anyway. It is very common for people to confuse parainfluenza with the canine influenza virus. They are both respiratory diseases that cause similar symptoms. However, ...
Background Respiratory tract infections (RTIs) are common in children and generally self-limiting, yet often result in consultations to primary care. Frequent consultations divert resources from care for potentially more serious conditions and increase the opportunity for antibiotic overuse. Overuse of antibiotics is associated with adverse effects and antimicrobial resistance, and has been shown to influence how patients seek care in ensuing illness episodes. Methodology/Principal Findings We conducted a systematic review and meta-analysis to assess the effectiveness of interventions directed towards parents or caregivers which were designed to influence consulting and antibiotic use for respiratory tract infections (RTIs) in children in primary care. Main outcomes were parental consulting rate, parental knowledge, and proportion of children subsequently consuming antibiotics. Of 5,714 references, 23 studies (representing 20 interventions) met inclusion criteria. Materials designed to engage children
RSV (Respiratory syncytial virus) is a virus that causes respiratory tract infections. RSV is a negative-sense, single-stranded RNA virus of the family Paramyxoviridae, which includes common respiratory viruses such as those causingmeasles and mumps. RSV is a member of the paramyxovirus subfamily Pneumovirinae. RSV is a major cause of lower respiratory tract infections and hospital visits during infancy and childhood.. ...
Sepsis-like syndrome (SLS, or blood infection) and acute respiratory infection (ARI, or chest infection) are two of the main types of severe viral infection in children. Often these children are so unwell they have to go to hospital. Rarely, long-term problems and even death can result from the infection. In the past bacteria were the main causes for many severe infections. However, due to successful vaccine programmes, viruses are now mostly to blame. This is worrying as viruses have the potential to cause large-scale outbreaks affecting the health of many people, as was the case in the recent worldwide swine flu outbreak. The focus of this study will be the specific viruses that are known to play a role in a proportion of severe cases of SLS and ARI. A better understanding of the role of viruses will help us to diagnose and manage affected children and work out how to better respond to outbreaks. The aim of this study is ...
Researchers have found heart complications in patients diagnosed with bacterial pneumonia are more serious than in patients diagnosed with viral pneumonia.
Viruses account for the largest proportion of childhood pneumonia. Viral pneumonia decreases in frequency in healthy young and middle-aged adults, but it then increases substantially among the elderly.
Healthy children in the ORChID community-based birth cohort experienced an incidence rate of 978 new VDEs per 100 child-years during the first 2 years of life, with HRV playing a dominant role. Overall, respiratory viruses were detected by PCR in regular weekly swabs at least once during 75% of ARIs, while in asymptomatic periods 23% of weekly nasal swabs were positive by PCR for respiratory viruses, accounting for 33% of all new VDEs. We demonstrated evidence of attribution for ARIs by RNA viruses, which included HRV (HRV-A, HRV-C), influenza (IFV-A), parainfluenza (PIV-1, PIV-3), RSV (RSV-A, RSV-B), HCoV (HCoV-OC43, HCoV-NL63) and HMPV; and AdV as the single DNA virus representative. All these viruses were detected significantly more often in children with an ARI than during asymptomatic periods and had statistically significant positive AFEs. The largest association was observed for RSV and HMPV, both of ...
GHENT, Belgium, 11 January 2017 - Ablynx [Euronext Brussels: ABLX; OTC: ABYLY] today announced that it has dosed the first patient in the Phase IIb "RESPIRE" dose-ranging efficacy study of ALX-0171, its novel inhaled drug candidate to treat RSV infections. Topline results from this Phase IIb study of inhaled ALX-0171 are expected in the second half of 2018.. Respiratory syncytial virus (RSV) is the most common cause of lower respiratory tract infections and the leading viral cause of severe lower respiratory tract disease in infants and young children worldwide. It is the primary cause of infant hospitalisation and virus associated deaths in infants, with estimated global annual infection and hospitalisation rates of 34 million and 3-4 million respectively[2]. Current treatment of RSV infections is primarily focused on symptomatic relief, hence the need for an effective and specific anti-RSV therapeutic. This Phase IIb study is a randomised, double-blind, ...
BioAssay record AID 423140 submitted by ChEMBL: Toxicity in hMPV infected BALB/c mouse assessed as body weight loss treated 24 hrs after viral challenge measured after 5 days.
MUC1 / EMA / CD227 (Epithelial Marker) Antibody - With BSA and Azide, Mouse Monoclonal Antibody [Clone HMPV ] validated in IHC-P, IF, FC (AH11857-20), Abgent
Evolve your syndromic respiratory testing with a fully automated, modular approach. The Panther Fusion® assays on the Panther Fusion® system increase flexibility to run patient-specific targets, allowing for personalized patient testing and better cost control in your lab.The Panther Fusion AdV/hMPV/RV assay is for the detection and differentiation of
anti-Meta-Pneumovirus, Alexa Fluor 647, Clone: HMPV57, Novus Biologicals 100 Tests; Alexa Fluor 647 Life Sciences:Antibodies:Primary Antibodies:Immunocytochemistry (ICC)
Background and purpose: There are different etiological agents of lower respiratory tract infections in children. Rate of their role is based on the age of patients, season, geographical areas and the used diagnostic methods. Âim of this study is to determine rate of infections causecl by these viruses in the ...
ShutterstockThe American Academy of Pediatrics (AAP) has released new guidelines that could affect the way severe lower respiratory tract disease from respiratory syncytial virus (RSV) is prevented. RSV is the most common cause of bronchiolitis and pneumonia in children younger than 1 year of age in the United States
We conducted surveillance at three hospitals (November 2007-December 2012) and tested nasopharyngeal and oropharyngeal swab specimens for HMPV and RSV using real-time reverse transcription-polymerase chain reaction. We calculated incidence rates, and compared the epidemiology and outcomes of HMPV-positive versus RSV-positive and RSV-HMPV-negative cases ...
1. For specimens received from 10 February 2014 onwards, molecular testing has replaced viral culture. Please interpret the data and trends in light of the enhanced sensitivity of molecular testing, and hence positive detection rates ...
According to a recent published paper, the American College of Physicians (ACP) and the Centers for Disease Control and Prevention (CDC) issued advice for prescribing antibiotics for acute respiratory tract infections (ARTIs) in adults.
Lower respiratory tract infections in children are often viral in origin. Unfortunately in this time of significant antimicrobial resistance of infectious organisms, especially bacteria, there is...
Lower Respiratory Tract Infections answers are found in the Washington Manual of Medical Therapeutics powered by Unbound Medicine. Available for iPhone, iPad, Android, and Web.
Rhedin S, Lindstrand A, Rotzén-Östlund M, et al. Clinical utility of PCR for common viruses in acute respiratory illness. Pediatrics. 2014 Mar;133(3):e538-45. Full-text for Childrens and Emory users. BACKGROUND: Acute respiratory illness (ARI) accounts for a large proportion of all visits to pediatric health facilities. Quantitative real-time polymerase chain reaction (qPCR) analyses allow sensitive detection of viral nucleic…
Expensive and labor intensive with no prevention of rare systemic disease; premedicate with beta-agonist inhaler 30 mins before treatment in smokers or in the setting of lower respiratory tract disease ...
1 Answer - Posted in: infections, respiratory tract disease, gemifloxacin - Answer: Gemifloxacin is a prescription medication that belongs to a group ...
Prevention of serious lower respiratory-tract disease caused by respiratory syncytial virus in children at high risk of the disease (under expert supervision) ...
Respiratory syncytial virus (RSV) is the most important cause of severe lower respiratory tract illness in infants and the elderly. Currently, no safe and effic...
Acute Respiratory Tract Infection (ARTI) is the most common disease among the general population, especially among children younger than 5. According...
The role of appropriate diagnostic testing in acute respiratory tract infections: An antibiotic stewardship strategy to minimize diagnostic uncertaint...
We review the the study Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data by the BMJ in regard to the amount of vitamin D needed to prevent colds and flu on a daily basis.
Tweets about Acute Respiratory Illness - NowTrending.HHS.gov is tracking disease trends and terms on twitter 140 characters at a time. The Now Trending 2012 HHS/ASPR app competition winner.
LOS ANGELES — Rhinovirus strains A and C were the most prevalent causes of respiratory tract infection among a cohort of preschool aged children, according to data presented at the 2016 American Academy of Allergy, Asthma & Immunology annual meeting.“Rhinovirus A and C were most commonly detected in nasal samples collected during respiratory tract illnesses [RTI],” Alalia W.
While the world is transfixed on the epic tragedy unfolding in Syria, another tragedy-a hidden one-has been consuming the children of Yemen. Battered by the twin evils of war and hunger, every ten minutes a child in Yemen is now dying from malnutrition, diarrhea and respiratory-tract infections.
EPA estimates that passive smoking is responsible for between 150,000 and 300,000 lower respiratory tract infections in infants and children under 18 months of age annually, resulting in between 7,500 ... to secondhand smoke are also more likely to have reduced lung function and symptoms of respiratory irritation like cough, excess phlegm, and wheeze. Passive smoking can lead to buildup of fluid ... ...
If you believe that digital publication of certain material infringes any of your rights or (privacy) interests, please let the Library know, stating your reasons. In case of a legitimate complaint, the Library will make the material inaccessible and/or remove it from the website. Please Ask the Library, or send a letter to: Library of the University of Amsterdam, Secretariat, Singel 425, 1012 WP Amsterdam, The Netherlands. You will be contacted as soon as possible. ...
Racing Pigeon products, Pigeon Supplies and Pigeon medicines. We have a massive range of pigeon medicines, such as pigeon antibiotic, vitamins, pigeon stimulant and more.
RTI (respiratory tract infections) are the infections of the sinuses, throat, lungs and airways. Most of these infections are caused by the bacteria...
Question - Suggest treatment for respiratory tract infection. Ask a Doctor about diagnosis, treatment and medication for Shortness of breath, Ask an Internal Medicine Specialist
This topic contains 1 study abstract on Respiratory Tract Infections: Prevention indicating that the following substance may be helpful: Vitamin D
Question - Suggest treatment for respiratory tract infection . Ask a Doctor about uses, dosages and side-effects of Crocin, Ask a Pediatrician
we can state that the level of IgG production induced by live aMPV vaccines is not a good indicator of the degree of protection, although it may be useful for differentiating between flocks in which high pressure from the field virus persists (with high levels of seroconversion) and flocks in which the vaccine is displacing the field virus.. ...
Health officials are seeing a spike in a lesser-known illness. Hospitals here are bringing in additional staff to meet the demand.

Croup in children | CMAJCroup in children | CMAJ

Pediatric hospitalizations for croup (laryngotracheobronchitis): biennial increases associated with human parainfluenza virus 1 ... respiratory syncytial virus, rhinovirus, coronavirus, human metapneumovirus and adenovirus.2,5,6 Predictable seasonal patterns ... Caused by a viral upper respiratory infection, croup is the second most common cause of respiratory distress in children. ... 3 Human parainfluenza virus (types 1 and 3) is the most common pathogen,4 but other causative viruses include influenza A and B ...
more infohttp://www.cmaj.ca/content/185/15/1317.full

Epithelial cell lines of the cotton rat (Sigmodon hispidus) are highly susceptible in vitro models to zoonotic Bunya -, Rhabdo ...Epithelial cell lines of the cotton rat (Sigmodon hispidus) are highly susceptible in vitro models to zoonotic Bunya -, Rhabdo ...

... as well as production of infectious virus particles. No viral replication was observed for novel arthropod-derived members of ... vesicular stomatitis virus (VSV), West Nile virus (WNV), and tick-borne encephalitis virus (TBEV) was tested. Furthermore, ... These cell lines may also serve as novel tools for virus isolation, as well as for the investigation of virus-host interactions ... Viral infection assays showed high-titre viral replication of RVFV, VSV, WNV, and TBEV, ...
more infohttps://virologyj.biomedcentral.com/articles/10.1186/s12985-016-0531-5

MERS-CoV | Interim Guidelines for Clinical Specimens from PUI | CDCMERS-CoV | Interim Guidelines for Clinical Specimens from PUI | CDC

... respiratory syncytial virus, human metapneumovirus, human parainfluenza viruses, adenovirus, human rhinovirus and other ... Virus isolation in cell culture and initial characterization of viral agents recovered in cultures of MERS-CoV specimens are ... For rRT-PCR testing (i.e., detection of the virus and not antibodies): A single serum specimen collected optimally during the ... Testing for common respiratory pathogens by molecular or antigen detection methods (not by viral culture) is strongly ...
more infohttps://www.cdc.gov/coronavirus/mers/guidelines-clinical-specimens.html

No Efficacy of Prednisolone in Acute Wheezing Associated Wit... : The Pediatric Infectious Disease JournalNo Efficacy of Prednisolone in Acute Wheezing Associated Wit... : The Pediatric Infectious Disease Journal

The efficacy of prednisolone in acute wheezing associated with human bocavirus infection ... parainfluenza virus (PIV) types 1-3, RSV, enteroviruses, rhinovirus, and human metapneumovirus (HMPV).2 Viral antigens were ... the corticosteroid does not seem to be effective on a virus infection itself, but rather, a susceptibility to certain viral ... Human bocavirus (HBoV) is a new parvovirus that was first identified in 2005 in Sweden.1 Soon after its discovery, HBoV was ...
more infohttps://journals.lww.com/pidj/Fulltext/2011/06000/No_Efficacy_of_Prednisolone_in_Acute_Wheezing.18.aspx

Low CCR7-Mediated Migration of Human Monocyte Derived Dendritic Cells in Response to Human Respiratory Syncytial Virus and...Low CCR7-Mediated Migration of Human Monocyte Derived Dendritic Cells in Response to Human Respiratory Syncytial Virus and...

Human respiratory syncytial virus (HRSV) and, to a lesser extent, human metapneumovirus (HMPV) and human parainfluenza virus ... and human parainfluenza virus type 3 (HPIV3) are common respiratory pathogens. HRSV is the most important viral agent of severe ... Human respiratory syncytial virus (HRSV) and, to a lesser extent, human metapneumovirus (HMPV) and human parainfluenza virus ... Effects of Human Respiratory Syncytial Virus, Metapneumovirus, Parainfluenza Virus 3 and Influenza Virus on CD4+ T Cell ...
more infohttps://www.prolekare.cz/casopisy/plos-pathogens/2011-6/low-ccr7-mediated-migration-of-human-monocyte-derived-dendritic-cells-in-response-to-human-respiratory-syncytial-virus-and-human-metapneumovirus-46075

Human Coronavirus NL63, France - Volume 11, Number 8-August 2005 - Emerging Infectious Diseases journal - CDCHuman Coronavirus NL63, France - Volume 11, Number 8-August 2005 - Emerging Infectious Diseases journal - CDC

The human coronavirus NL63 (HCoV-NL63) was first identified in the Netherlands, and its circulation in France has not been ... All specimens were tested for influenza virus A and B; respiratory syncytial virus (RSV); parainfluenza virus 1, 2, 3, and 4; ... Samples were also tested for human metapneumovirus (HMPV), rhinovirus, enterovirus, and HCoV 229E and OC43 by virus isolation ... Symptoms indicated viral infection, as judged by the clinical department; therefore, samples were not tested for bacterial ...
more infohttps://wwwnc.cdc.gov/eid/article/11/8/05-0110

Assessing wheeze in pre-school children - BPJ 56 November 2013Assessing wheeze in pre-school children - BPJ 56 November 2013

... viral infection. The most common causative viruses include rhinovirus, coronavirus, human metapneumovirus, parainfluenza virus ... Episodic viral wheeze. Episodic viral wheeze, also referred to as non-atopic wheeze, is wheezing associated with viral upper ... have a viral illness, and more severe exacerbations will be present when the child has a viral illness.2 ... Episodic viral wheeze is most common in children from age ten months up until age three years.1 Children who develop wheeze as ...
more infohttps://bpac.org.nz/BPJ/2013/November/wheeze.aspx

Plus itPlus it

... human metapneumovirus (hMPV), and respiratory syncytial virus (RSV) (D3 Double Duet DFA Respiratory Virus Screening and ID Kit ... assay and two different viral PCR tests. DFA was performed for influenza virus A and B, parainfluenza virus 1, 2 and 3, ... All 60 controls with viral study had a negative DFA assay, and genomes of AdV and parainfluenza virus 4 were found in three and ... influenza virus A, B and C, RSV A and B, AdV, coronavirus 229E and OC43, enterovirus, parainfluenza virus 1, 2, 3 and 4, and ...
more infohttps://erj.ersjournals.com/content/39/5/1144

Antibiotic misuse in respiratory tract infections in children and adults-a prospective, multicentre study (TAILORED Treatment) ...Antibiotic misuse in respiratory tract infections in children and adults-a prospective, multicentre study (TAILORED Treatment) ...

... are more commonly caused by viral pathogens in children than in adults. Surprisingly, little is known about antibiotic use in ... human metapneumovirus and parainfluenza virus. Table 3 Comparison of patients with viral and bacterial reference standards. a. ... bIncludes coronavirus, human metapneumovirus, and parainfluenza virus. cNumbers of antibiotic usages are given per virus. As ... Five adult ICU patients had viral infections, and one patient had a bacterial infection. Influenza virus was detected in four ...
more infohttps://link.springer.com/article/10.1007%2Fs10096-018-03454-2

H1N1 Influenza Virus and HCT Patients - American Society for Blood and Marrow TransplantationH1N1 Influenza Virus and HCT Patients - American Society for Blood and Marrow Transplantation

Respiratory Syncytial Virus, Human Metapneumovirus and Parainfluenza Virus. M. Tomblyn, T. Chiller, H. Einsele, R. Gress, K. ... Viral cultures of asymptomatic HCT candidates are unlikely to be useful. Whether multiplex PCR testing can identify ... H1N1 Influenza Virus and HCT Patients. Special precautions are indicated with respect to the H1N1 influenza virus ("Swine Flu ... because respiratory syncytial virus (RSV), influenza, parainfluenza, and adenovirus URIs can progress to more serious lower ...
more infohttps://www.asbmt.org/practice-resources/practice-guidelines/h1n1-influenza-virus-and-hct-patients

https://www.medicalnewstoday.com/articles/155932.phphttps://www.medicalnewstoday.com/articles/155932.php

Human parainfluenza virus 1 (HPIV-1) is the most common cause of croup, with types 1 and 2 causing 66 percent of infections. ... Viral croup. Respiratory syncytial virus is one of the causes of viral croup. ... What is respiratory syncytial virus (RSV)? Respiratory syncytial virus is a viral infection that affects the lungs and ... and 3 of the human parainfluenza virus account for 80 percent of all cases of croup. ...
more infohttps://www.medicalnewstoday.com/articles/155932.php

Benign Acute Childhood Myositis: Perplexing Complication after Acute Viral PharyngitisBenign Acute Childhood Myositis: Perplexing Complication after Acute Viral Pharyngitis

A nasopharyngeal aspirate (NPA) was taken to test for influenza A and B; human parainfluenza virus types 1, 2, and 3; ... respiratory syncytial virus; adenovirus; and human metapneumovirus (routine panel) by polymerase chain reaction. The NPA ... parainfluenza, Coxsackie virus, herpes simplex virus, Epstein-Barr virus, and adenovirus infections [4]. Data from animal ... this suggests that the virus is unable to replicate in this tissue [5]. However, in some cases, influenza virus antigens were ...
more infohttps://www.kjfm.or.kr/journal/view.php?doi=10.4082/kjfm.17.0113

A novel sampling method to detect airborne influenza and other respiratory viruses in mechanically ventilated patients: a...A novel sampling method to detect airborne influenza and other respiratory viruses in mechanically ventilated patients: a...

... and human metapneumovirus. For each patient, we also performed a full virology screen (virus particles, antibody titres and ... influenza virus A and B, parainfluenza virus (type 1, 2 and 3) ... there was no evidence of clinical signs of an active viral ... A third of the patients with a positive virus detection in the ventilator filters had a hospital laboratory confirmed viral ... The most common virus detected was influenza A virus (n = 29). There were more viruses detected in the inspiratory filters (n ...
more infohttps://annalsofintensivecare.springeropen.com/articles/10.1186/s13613-018-0396-4

In young children, persistent wheezing is associated with bronchial bacterial infection: a retrospective analysis | BMC...In young children, persistent wheezing is associated with bronchial bacterial infection: a retrospective analysis | BMC...

Respiratory viruses were detected in 21,9 % of cases with mixed bacterial-viral infection in 12,1 %. Cytology revealed a marked ... However, we may have missed some cases of viral infection because human rhinovirus was not included in the applied PCR-protocol ... human metapneumovirus subtypes A and B; coronaviruses 229E and OC43, Mycoplasma pneumoniae and Chlamydophila pneumoniae using ... Respiratory viruses were detected in 7 of 32 (21.9 %) cases, with predominance of respiratory syncytial virus (RSV) (Table 2). ...
more infohttps://bmcpediatr.biomedcentral.com/articles/10.1186/1471-2431-12-83

RNA respiratory viral infections in solid organ transplant recipients: Guidelines from the American Society of Transplantation...RNA respiratory viral infections in solid organ transplant recipients: Guidelines from the American Society of Transplantation...

Viruses reviewed include influenza, respiratory syncytial virus (RSV), parainfluenza, rhinovirus, human metapneumovirus (hMPV ... Respiratory viral infections may be associated with acute rejection and chronic lung allograft dysfunction in lung transplant ... RNA respiratory viral infections in solid organ transplant recipients: Guidelines from the American Society of Transplantation ... Diagnosis is by nucleic acid testing due to improved sensitivity, specificity, broad range of detection of viral pathogens, ...
more infohttps://www.ncbi.nlm.nih.gov/pubmed/30817023?dopt=Abstract

Middle East Respiratory Syndrome in 3 Persons, South Korea, 2015 - Volume 21, Number 11-November 2015 - Emerging Infectious...Middle East Respiratory Syndrome in 3 Persons, South Korea, 2015 - Volume 21, Number 11-November 2015 - Emerging Infectious...

... influenza virus A and B; human adenovirus; bocavirus; human parainfluenza virus types 1, 2, and 3; respiratory syncytial virus ... Poissy J, Goffard A, Parmentier-Decrucq E, Favory R, Kauv M, Kipnis E, Kinetics and pattern of viral excretion in biological ... A and B; human rhinovirus; human metapneumovirus).. For the index patient, MERS-CoV RNA was detectable in sputum, throat swab, ... Corman VM, Eckerle I, Bleicker T, Zaki A, Landt O, Eschbach-Bludau M, Detection of a novel human coronavirus by real-time ...
more infohttps://wwwnc.cdc.gov/eid/article/21/11/15-1016

Product ClassificationProduct Classification

... and Parainfluenza 3 virus, Human Metapneumovirus, Rhinovirus, and Adenovirus.. Physical State. A qualitative in vitro ... and/or differentiate multiple respiratory virus nucleic acid extracted from human respiratory specimens or viral cultures. ... Respiratory Syncytial Virus subtype A and Respiratory Syncytial Virus subtype B, Parainfluenza 1, Parainfluenza 2, ... and/or differentiate multiple respiratory virus nucleic acid extracted from human respiratory specimens or viral cultures. ...
more infohttps://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfpcd/classification.cfm?id=3553

Use of TaqMan Array card for the detection of respiratory viral pathogens in children under 5 years old hospitalised with acute...Use of TaqMan Array card for the detection of respiratory viral pathogens in children under 5 years old hospitalised with acute...

Use of TaqMan Array card for the detection of respiratory viral pathogens in children under 5 years old hospitalised with ... respiratory syncytial virus (RSV); parainfluenza viruses 1-3; human metapneumovirus; rhinovirus; coronaviruses 229E, OC43, NL63 ... Use of TaqMan Array card for the detection of respiratory viral pathogens in children under 5 years old hospitalised with acute ... it s important to note that current global circumstances suggest it is likely that this virus will cause a pandemic. In that ...
more infohttps://flutrackers.com/forum/forum/welcome-to-the-scientific-library/diagnosis-testing/816848-use-of-taqman-array-card-for-the-detection-of-respiratory-viral-pathogens-in-children-under-5-years-old-hospitalised-with-acute-medical-illness-in-ballabgarh-haryana-india

TMPRSS2 Gene - GeneCards | TMPS2 Protein | TMPS2 AntibodyTMPRSS2 Gene - GeneCards | TMPS2 Protein | TMPS2 Antibody

Serine 2, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium ... and the fusion glycoproteins F0 of Sendai virus (SeV), human metapneumovirus (HMPV), human parainfluenza 1, 2, 3, 4a and 4b ... Serine protease that proteolytically cleaves and activates the viral spike glycoproteins which facilitate virus-cell membrane ... and the fusion glycoproteins F0 of Sendai virus (SeV), human metapneumovirus (HMPV), human parainfluenza 1, 2, 3, 4a and 4b ...
more infohttp://www.genecards.org/cgi-bin/carddisp.pl?gene=TMPRSS2

Upper Respiratory Tract InfectionsUpper Respiratory Tract Infections

... parainfluenza virus, coronavirus, adenovirus, respiratory syncytial virus, Coxsackie virus, human metapneumovirus, and ... and rash should raise the possibility of a systemic viral infection, such as Epstein-Barr virus, cytomegalovirus, or human ... Similar tests are also available for adenovirus, respiratory syncytial virus, human metapneumovirus and parainfluenza virus. ... Viral culture, rapid antigen detection, or polymerase chain reaction (PCR) assay of influenza virus on a nasopharyngeal swab is ...
more infohttp://www.clevelandclinicmeded.com/medicalpubs/diseasemanagement/infectious-disease/upper-respiratory-tract-infection/

1744666X.2017.13896471744666X.2017.1389647

... respiratory syncytial virus; Flu A, influenza A; Flu B, influenza B; hMPV, human metapneumovirus; PIV 1, parainfluenza virus ... RSV viral titers undetectable in lungs for all RI-002 groups. [50] Euthanized on Day 4. Virus detectable in 5/5 animals treated ... An additional virus nano-filtration step to increase product safety and further reduce the probability of transmission of viral ... Aggregate ratio of geometric mean titers (RI-002/IVIG) was 1.529 (1.227, 1.907). Although human metapneumovirus titers were ...
more infohttps://www.docme.ru/doc/2199724/1744666x.2017.1389647

Dr. Stefan  Niewiesk - Cancer Researcher at OSUCCC - JamesDr. Stefan Niewiesk - Cancer Researcher at OSUCCC - James

We use the mouse model of adult T cell leukemia to study the interaction between tumor cells, microenviroment and virus. One ... One of the interests of the Niewiesk laboratory is the use of measles vaccine virus as oncolytic therapy to cure T cell ... Phosphorylation of Human Metapneumovirus M2-1 Protein Upregulates Viral Replication and Pathogenesis.. Cai H, Zhang Y, Lu M, ... Features of Circulating Parainfluenza Virus Required for Growth in Human Airway.. Palermo LM, Uppal M, Skrabanek L, Zumbo P, ...
more infohttps://cancer.osu.edu/research-and-education/find-a-researcher/search-researcher-directory/stefan-niewiesk

Bronchiolitis: Practice Essentials, Background, PathophysiologyBronchiolitis: Practice Essentials, Background, Pathophysiology

Bronchiolitis is an acute inflammatory injury of the bronchioles that is usually caused by a viral infection. Although it may ... human metapneumovirus (hMPV), parainfluenza virus, adenovirus, coronavirus, influenza virus or human bocavirus. In one third of ... Respiratory syncytial virus infections in hospitalized infants: association between viral load, virus subgroup, and disease ... Dual infection of infants by human metapneumovirus and human respiratory syncytial virus is strongly associated with severe ...
more infohttps://emedicine.medscape.com/article/961963-overview

Simultaneous Detection and High-Throughput Identification of a Panel of RNA Viruses Causing Respiratory Tract Infections |...Simultaneous Detection and High-Throughput Identification of a Panel of RNA Viruses Causing Respiratory Tract Infections |...

Well-recognized respiratory viral pathogens include influenza virus A (Flu-A) and Flu-B, parainfluenza virus 1 (PIV-1), PIV-2, ... human metapneumovirus (hMPV), respiratory syncytial virus (RSV), rhinovirus (RhV), and enterovirus (EnV), which can cause a ... Direct detection of respiratory syncytial virus, parainfluenza virus, and adenovirus in clinical respiratory specimens by a ... and human parainfluenza virus types 1, 2, and 3 by multiplex quantitative reverse transcription-polymerase chain reaction- ...
more infohttps://jcm.asm.org/content/45/7/2105?ijkey=b8c81d09351ea72ad5e05c158c09cce0f00eff6b&keytype2=tf_ipsecsha
  • The cotton rat ( Sigmodon hispidus ) is a New World rodent species that has a long-standing history as an experimental animal model due to its unique susceptibility to human viruses. (biomedcentral.com)
  • In light of the large species range in which novel and potentially zoonotic viruses have been discovered, there remains a need for suitable in vitro models to understand virus-host interactions, interspecies spillover, and general viral pathogenicity [ 15 ]. (biomedcentral.com)
  • The cotton rat ( Sigmodon hispidus ) is a unique example of a rodent species that is a well-established animal model to study viral pathogenesis and is also associated with a large range of zoonotic viruses in the wild [ 20 - 22 ]. (biomedcentral.com)
  • These cell lines may also serve as novel tools for virus isolation, as well as for the investigation of virus-host interactions in a relevant host species. (biomedcentral.com)
  • In the current study, we showed that newly established cell lines from the cotton rat can serve as host-specific in vitro models for viral infection experiments. (biomedcentral.com)
  • They are represented by 2 prototype strains, HCoV-229E and HCoV-OC43, which belong to antigenic groups 1 and 2, respectively. (cdc.gov)
  • Building on discoveries that Prince made as a doctoral student, VSI pioneered the prevention of respiratory syncytial virus (RSV) disease in high-risk infants through the use of monoclonal antibody. (wikipedia.org)
  • Patients were grouped as bacterial, viral/atypical and mixed CAP, and were followed up at 30, 90 and 180 days, and 1 yr. (ersjournals.com)
  • Additionally, the levels of virus-induced biomarker in these patients were not statistically different from those of non-infected patients ( p = 0.33). (springeropen.com)
  • While test sensitivities for RSV and PIV-3 need improvement, both the NGEN and ResPlex II assays provide user-friendly and high-throughput tools for simultaneous detection and identification of a panel of common respiratory viral pathogens in a single test format. (asm.org)
  • For each patient, we also performed a full virology screen (virus particles, antibody titres and virus-induced biomarkers) on respiratory samples (nasopharyngeal swab, tracheal aspirate or bronchoalveolar fluid) and blood samples. (springeropen.com)
  • 2 Other less common causes of bacterial pharyngitis include group C beta-hemolytic streptococci, Corynebacterium diphtheriae, Neisseria gonorrhoeae, Arcanobacterium haemolyticum, Chlamydophila (formerly Chlamydia) pneumoniae, Mycoplasma pneumoniae, and herpes simplex virus. (clevelandclinicmeded.com)
  • cChief Medical and Scientific Officer- ADMA Biologics Inc., Ramsey, NJ, USA Downloaded by [Linköping University Library] at 19:14 26 October 2017 a ABSTRACT ARTICLE HISTORY Introduction: Novel immune globulin (IG) products (RI-002, RI-001) have been designed to provide protection against respiratory syncytial virus (RSV) mediated respiratory illness while at the same time meeting the manufacturing requirements established by FDA for antibody supplementation in immunocompromised subjects. (docme.ru)
  • 2 It can be challenging for the clinician to differentiate those young children who will go on to have asthma from those who will not. (bpac.org.nz)
  • Since many clinicians are unfamiliar with BACM, it is often misdiagnosed and interpreted as a more severe and complex disease [ 2 , 3 ]. (kjfm.or.kr)
  • Collect 2-3 mL into a sterile, leak-proof, screw-cap sputum collection cup or sterile dry container. (cdc.gov)
  • Sputum samples from 2 persons who had been in contact with the index patient were also tested for MERS-CoV. (cdc.gov)
  • Human bocavirus (HBoV) is a new parvovirus that was first identified in 2005 in Sweden. (lww.com)