Cell Adhesion Molecules
Differentiation antigens residing on mammalian leukocytes. CD stands for cluster of differentiation, which refers to groups of monoclonal antibodies that show similar reactivity with certain subpopulations of antigens of a particular lineage or differentiation stage. The subpopulations of antigens are also known by the same CD designation.
Immunized T-lymphocytes which can directly destroy appropriate target cells. These cytotoxic lymphocytes may be generated in vitro in mixed lymphocyte cultures (MLC), in vivo during a graft-versus-host (GVH) reaction, or after immunization with an allograft, tumor cell or virally transformed or chemically modified target cell. The lytic phenomenon is sometimes referred to as cell-mediated lympholysis (CML). These CD8-positive cells are distinct from NATURAL KILLER CELLS and NATURAL KILLER T-CELLS. There are two effector phenotypes: TC1 and TC2.
Antigens, Tumor-Associated, Carbohydrate
Tumor Markers, Biological
Molecular products metabolized and secreted by neoplastic tissue and characterized biochemically in cells or body fluids. They are indicators of tumor stage and grade as well as useful for monitoring responses to treatment and predicting recurrence. Many chemical groups are represented including hormones, antigens, amino and nucleic acids, enzymes, polyamines, and specific cell membrane proteins and lipids.
Carbohydrate antigen elevated in patients with tumors of the breast, ovary, lung, and prostate as well as other disorders. The mucin is expressed normally by most glandular epithelia but shows particularly increased expression in the breast at lactation and in malignancy. It is thus an established serum marker for breast cancer.
Antigens, Polyomavirus Transforming
Polyomavirus antigens which cause infection and cellular transformation. The large T antigen is necessary for the initiation of viral DNA synthesis, repression of transcription of the early region and is responsible in conjunction with the middle T antigen for the transformation of primary cells. Small T antigen is necessary for the completion of the productive infection cycle.
Tissue Polypeptide Antigen
Classic quantitative assay for detection of antigen-antibody reactions using a radioactively labeled substance (radioligand) either directly or indirectly to measure the binding of the unlabeled substance to a specific antibody or other receptor system. Non-immunogenic substances (e.g., haptens) can be measured if coupled to larger carrier proteins (e.g., bovine gamma-globulin or human serum albumin) capable of inducing antibody formation.
A malignant neoplasm derived from glandular epithelium, in which cystic accumulations of retained secretions are formed. The neoplastic cells manifest varying degrees of anaplasia and invasiveness, and local extension and metastases occur. Cystadenocarcinomas develop frequently in the ovaries, where pseudomucinous and serous types are recognized. (Stedman, 25th ed)
Allergy and Immunology
Complex of at least five membrane-bound polypeptides in mature T-lymphocytes that are non-covalently associated with one another and with the T-cell receptor (RECEPTORS, ANTIGEN, T-CELL). The CD3 complex includes the gamma, delta, epsilon, zeta, and eta chains (subunits). When antigen binds to the T-cell receptor, the CD3 complex transduces the activating signals to the cytoplasm of the T-cell. The CD3 gamma and delta chains (subunits) are separate from and not related to the gamma/delta chains of the T-cell receptor (RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA).
White blood cells formed in the body's lymphoid tissue. The nucleus is round or ovoid with coarse, irregularly clumped chromatin while the cytoplasm is typically pale blue with azurophilic (if any) granules. Most lymphocytes can be classified as either T or B (with subpopulations of each), or NATURAL KILLER CELLS.
Lymphocytes responsible for cell-mediated immunity. Two types have been identified - cytotoxic (T-LYMPHOCYTES, CYTOTOXIC) and helper T-lymphocytes (T-LYMPHOCYTES, HELPER-INDUCER). They are formed when lymphocytes circulate through the THYMUS GLAND and differentiate to thymocytes. When exposed to an antigen, they divide rapidly and produce large numbers of new T cells sensitized to that antigen.
A vitamin that includes both CHOLECALCIFEROLS and ERGOCALCIFEROLS, which have the common effect of preventing or curing RICKETS in animals. It can also be viewed as a hormone since it can be formed in SKIN by action of ULTRAVIOLET RAYS upon the precursors, 7-dehydrocholesterol and ERGOSTEROL, and acts on VITAMIN D RECEPTORS to regulate CALCIUM in opposition to PARATHYROID HORMONE.
Vitamin D Deficiency
A nutritional condition produced by a deficiency of VITAMIN D in the diet, insufficient production of vitamin D in the skin, inadequate absorption of vitamin D from the diet, or abnormal conversion of vitamin D to its bioactive metabolites. It is manifested clinically as RICKETS in children and OSTEOMALACIA in adults. (From Cecil Textbook of Medicine, 19th ed, p1406)
Diabetes Mellitus, Type 2
A subclass of DIABETES MELLITUS that is not INSULIN-responsive or dependent (NIDDM). It is characterized initially by INSULIN RESISTANCE and HYPERINSULINEMIA; and eventually by GLUCOSE INTOLERANCE; HYPERGLYCEMIA; and overt diabetes. Type II diabetes mellitus is no longer considered a disease exclusively found in adults. Patients seldom develop KETOSIS but often exhibit OBESITY.
Retinol and derivatives of retinol that play an essential role in metabolic functioning of the retina, the growth of and differentiation of epithelial tissue, the growth of bone, reproduction, and the immune response. Dietary vitamin A is derived from a variety of CAROTENOIDS found in plants. It is enriched in the liver, egg yolks, and the fat component of dairy products.
Carcinoembryonic antigen-related cell adhesion molecule 7 is a protein that in humans is encoded by the CEACAM7 gene. ... 1998). "Expression of four CEA family antigens (CEA, NCA, BGP and CGM2) in normal and cancerous gastric epithelial cells: up- ... "Entrez Gene: CEACAM7 carcinoembryonic antigen-related cell adhesion molecule 7". Human CEACAM7 genome location and CEACAM7 gene ... "Four carcinoembryonic antigen subfamily members, CEA, NCA, BGP and CGM2, selectively expressed in the normal human colonic ...
... is a human glycoprotein, and a member of the carcinoembryonic antigen (CEA) gene family. This gene encodes a member of the ... "Immunochemical analysis of carcinoembryonic antigen (CEA)-related antigens differentially localized in intracellular granules ... Carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) (CEACAM1) also known as CD66a (Cluster of ... "Entrez Gene: CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)". Hoek KS, Schlegel NC, ...
... carcinoembryonic antigen-related cell adhesion molecule 3". CEACAM3: an innate immune receptor directed against human- ... 1991). "Molecular cloning of nonspecific cross-reacting antigens in human granulocytes". J. Biol. Chem. 266 (18): 11810-7. PMID ... is a member of the carcinoembryonic antigen (CEA) gene family.. This gene encodes a member of the family of carcinoembryonic ... Carcinoembryonic antigen-related cell adhesion molecule 3 (CEACAM3) also known as CD66d (Cluster of Differentiation 66d), ...
Khan WN, Hammarström S (1990). "Identification of a new carcinoembryonic antigen (CEA) family member in human fetal liver-- ... 1989). "Carcinoembryonic antigens: alternative splicing accounts for the multiple mRNAs that code for novel members of the ... 1990). "The human pregnancy-specific glycoprotein genes are tightly linked on the long arm of chromosome 19 and are ... carcinoembryonic antigen family". J. Cell Biol. 108 (2): 267-76. doi:10.1083/jcb.108.2.267. PMC 2115422. PMID 2537311. Teglund ...
... like the carcinoembryonic antigen (CEA) or the prostate specific antigen (PSA). Novel strategies will be required to identify ... Loss of tumor antigen expression is another cause of escape from immune recognition. This occurs because most tumor antigens ... However downmodulation or complete loss of MHC-I expression occurs in most human tumors, making them altogether invisible to ... Most tumor antigens are not oncoantigens, either because they are intracellular molecules, like cancer-testis antigen such as ...
In addition, she showed that carcinoembryonic antigen forms dimers in solution and was the first to demonstrate that human Band ... For many years Lisowska worked on the M and N antigens. She identified that these antigens were carried by the glycosylated ... which is the cause of NOR polyagglutination and a member of the human P1PK antigen system. and showed that the NOR antigen is ... She characterized several lectins, including Vicia graminea lectin which is specific for human N blood group antigen, described ...
... but it took roughly two more decades before it was demonstrated that they target human tumour associated antigens in cancer ... "Use of Radio-Labeled Antibodies to Carcinoembryonic Antigen for the Detection and Localization of Diverse Cancers by External ... However, these types of antibodies turned out to be quite troublesome, due to the triggering of the human anti-murine antibody ... The beginning of the pretargeting concept was based on bispecific antibodies which were able to bind a specific target antigen ...
Gold P, Freedman SO (March 1965). "DEMONSTRATION OF TUMOR-SPECIFIC ANTIGENS IN HUMAN COLONIC CARCINOMATA BY IMMUNOLOGICAL ... In humans, the carcinoembryonic antigen family consists of 29 genes, 18 of which are normally expressed. The following is a ... Carcinoembryonic Antigen at the US National Library of Medicine Medical Subject Headings (MeSH) CEA at Lab Tests Online CEA: ... list of human genes which encode carcinoembryonic antigen-related cell adhesion proteins: CEACAM1, CEACAM3, CEACAM4, CEACAM5, ...
Korínek V, Stefanová I, Angelisová P, Hilgert I, Horejsí V (1991). "The human leucocyte antigen CD48 (MEM-102) is closely ... LFA-3 and carcinoembryonic antigens". EMBO J. 7 (10): 3087-91. doi:10.1002/j.1460-2075.1988.tb03174.x. PMC 454697. PMID 3181129 ... Vaughan HA, Thompson CH, Sparrow RL, McKenzie IF (October 1983). "Hu Ly-M3--a human leukocyte antigen". Transplantation. 36 (4 ... Henniker AJ, Bradstock KF, Grimsley P, Atkinson MK (1990). "A novel non-lineage antigen on human leucocytes: characterization ...
In humans, the CD44 antigen is encoded by the CD44 gene on Chromosome 11. CD44 has been referred to as HCAM (homing cell ... Thomas SN, Zhu F, Schnaar RL, Alves CS, Konstantopoulos K (Jun 2008). "Carcinoembryonic antigen and CD44 variant isoforms ... "The Ina and Inb blood group antigens are located on a glycoprotein of 80,000 MW (the CDw44 glycoprotein) whose expression is ... Indian blood group system at BGMUT Blood Group Antigen Gene Mutation Database at NCBI, NIH Articles at IHOP. Human CD44 genome ...
Samuel O. Freedman
In 1965, he co-discovered with Phil Gold the carcinoembryonic antigen, the basis of a blood test used in the diagnosis and ... Demonstration of tumor-specific antigens in human colonic carcinomata by immunological tolerance and absorption techniques. J ... Prix Armand-Frappier Citation (in French)  Order of Canada Citation v t e. ...
Carcinoembryonic antigen (CEA) and/or Mucin 1 (MUC1), which are all tumor markers that are overexpressed in various cancers. ... MVA-BN is characterized by the inability to replicate in human cells, contrary to other vaccinia-based vaccines, which may ... poxvirus-based immunotherapy can be modified to encode different tumor-associated antigens such as Prostate-specific antigen ( ... "Products for Human Use. Submission #144762". Register of Innovative Drugs. Health Canada. 13 June 2014. 144762 (Submission ...
... and Carcinoembryonic Antigen Related Cell Adhesion Molecule 1 (CEACAM1). The binding of PtdSer has been shown to cause an ... "Tumor antigen-specific CD8+ T cells are negatively regulated by PD-1 and Tim-3 in human gastric cancer". Cellular Immunology. ... uptake of apoptotic cells and reduced cross presentation of dying cell-associated antigens by dendritic cells. The binding of ... March 2012). "Tim-3 is an inducible human natural killer cell receptor that enhances interferon gamma production in response to ...
... is related to carcinoembryonic antigens, which have been found to reduce drug toxicity by Kawaharata et al. NCI-H1688, a human ... the nonspecific cross-reacting antigen of carcinoembryonic antigen". Cancer Res. 57 (24): 5460-5464. PMID 9407950. Kawaharata H ... Hinoda Y, Itoh F, Endo T, Oikawa S, Nakazato H, Imai K (July 1997). "Decreased sensitivity of carcinoembryonic antigen cDNA- ... H19 is a gene for a long noncoding RNA, found in humans and elsewhere. H19 has a role in the negative regulation (or limiting) ...
Carcinoembryonic antigen blood level measurements follow the same timing, but are only advised for people with T2 or greater ... It has been suggested that the presence of antibodies to Streptococcus bovis/gallolyticus antigens or the antigens themselves ... Jacinto FV, Esteller M (July 2007). "Mutator pathways unleashed by epigenetic silencing in human cancer". Mutagenesis. 22 (4): ... 29 (2): 222-8. doi:10.1159/000323926. PMID 21734388.. *^ a b c d e f g h i j k l m n o p q r s t Cunningham D, Atkin W, Lenz HJ ...
I. Partial characterization of soluble Ki-1 antigen and detection of the antigen in cell culture supernatants and in serum by ... Fonatsch C, Latza U, Dürkop H, Rieder H, Stein H (Nov 1992). "Assignment of the human CD30 (Ki-1) gene to 1p36". Genomics. 14 ( ... CD30+Antigens at the US National Library of Medicine Medical Subject Headings (MeSH) ... Human TNFRSF8 genome location and TNFRSF8 gene details page in the UCSC Genome Browser. ...
Pattern recognition receptor
CTLD is a ligand binding motif found in more than 1000 known proteins (more than 100 in humans) and the ligands are often not ... PRRs also mediate the initiation of antigen-specific adaptive immune response and release of inflammatory cytokines. The ... In addition, many of acquired nonself surfaces e.g. carcinoembryonic/oncofetal type neoantigens carrying "internal danger ... Tissue Antigens. 68 (3): 193-209. doi:10.1111/j.1399-0039.2006.00649.x. PMC 7169806. PMID 16948640. "Understanding ...
In 1995, Robert Conry demonstrated that intramuscular injection of naked RNA encoding carcinoembryonic antigen elicited antigen ... Based on this discovery, first-in-human testing of the injection of naked IVT mRNA encoding cancer antigens by BioNTech has ... January 2008). "Increased antigen presentation efficiency by coupling antigens to MHC class I trafficking signals". Journal of ... There are a few phase I and II clinical trials using IVT mRNA encoding combinations and it shows that antigen-specific CD8+ and ...
... carcinoembryonic antigen (CEA), carbohydrate antigens CA 19-9 and CA 724 in the diagnosis of gastrointestinal cancer". ... Gupta V, Bamezai RN (Sep 2010). "Human pyruvate kinase-M2: "A multi-functional protein"". Protein Sci. 19 (11): 2031-44. doi: ... M2-PK is upgregulated in many human tumors. M2-PK can occur in two different forms in proliferating cells: a tetrameric form, ... "Differential behavior of missense mutations in the intersubunit contact domain of the human pyruvate kinase M2 isozyme". J. ...
Carcinoembryonic antigen cell adhesion molecule-1 (Caecam1) is an immunoglobulin-like co-receptor that aids in cell adhesion in ... Crystal structure of the human CD4 N-terminal two-domain fragment complexed to a class II MHC molecule. Proc. Natl Acad Sci USA ... or CD28 to bind antigens or regulate T cell activity in some way. Many co-receptor-related disorders occur due to mutations in ... The HIV receptors CXCR4 and CCR5 are differentially expressed and regulated on human T-cells. Proc. Natl. Acad. Sci. USA. Vol. ...
... cervical cancers Carcinoembryonic antigen (CEA) for breast, lung and colon cancers "Phase 1 Study Of Lapuleucel-T In Advanced ... An ongoing example is Karposi's sarcoma (KS) caused by the Human herpesvirus 8 virus normally controlled by the body's immune ... This 1997 example article describes targeting EGFR and other cell products and attaching their antigens to the CD64 receptor ... including antigen presenting cells, which are cultured ex vivo with BA7072, a recombinant fusion antigen consisting of portions ...
... including human complement factor H-related protein, high-molecular-weight carcinoembryonic antigen, and nuclear matrix protein ... ImmunoCyt is an Immunofluorescence test which detects glycosylated CEA and MUCIN-like antigens (M344, LDQ10, 19A11). BTA-STAT ... Humans, IARC Working Group on the Evaluation of Carcinogenic Risk to (2012). 2-NAPHTHYLAMINE. International Agency for Research ... BTA-TRAK is a sandwich ELISA which also detects human complement factor H-related protein. Sensitivities across biomarkers ...
Human Carcino Embryonic Antigen CEA ELISA Kit | Abcam
... suitable for Serum in human. Reliably quantify 1 ng/ml of Carcino Embryonic Antigen CEA. ... Abcams Carcino Embryonic Antigen CEA ELISA Kit (ab108635) ... Human Carcino Embryonic Antigen ELISA Kit (CEA). See all ... Anti-Carcino Embryonic Antigen Coated Microplate (12 x 8 wells). 1 unit. Anti-Carcino Embryonic Antigen HRP Conjugate. 1 x 13ml ... Added Anti-Carcino Embryonic Antigen-HRP conjugate binds to the antibody-Carcino Embryonic Antigen complex. After incubation, ...
Chimeric Antigen Receptor-Modified T Cells for Solid Tumors: Challenges and Prospects
Recent studies have highlighted the successes of chimeric antigen receptor-modified T- (CART-) cell-based therapy for B-cell ... carcinoembryonic antigen; CR: complete response; DOD: dead of disease; FR: folate receptor; HER2: human epidermal growth factor ... antigens such as tissue/lineage antigens, developmental antigens, and overexpressed antigens . Most of the recent studies ... M. V. Maus, A. R. Haas, G. L. Beatty et al., "T cells expressing chimeric antigen receptors can cause anaphylaxis in humans," ...
Frontiers | The Epitope-Specific Anti-human CD4 Antibody MAX.16H5 and Its Role in Immune Tolerance | Immunology
An anti-human CD4 antibody (MAX.16H5) was applied intravenously in clinical trials for the treatment of autoimmune diseases (e. ... inheriting CD4-directed variable domains of the MAX.16H5 IgG1 connected to a human IgG4 backbone. Both antibodies were studied ... inheriting CD4 directed variable domains of the MAX.16H5 IgG1 connected to a human IgG4 backbone. Both antibodies were studied ... An anti human CD4 antibody (MAX.16H5) was applied intravenously in clinical trials for the treatment of autoimmune diseases (e. ...
Associations between Vitamin D and β-Cell Function and Colorectal Cancer-Associated Tumor Markers in Chinese Type 2 Diabetic...
Antigens, Tumor-Associated, Carbohydrate * Biomarkers, Tumor * CA-125 Antigen * Carcinoembryonic Antigen * MUC16 protein, human ... carcinoembryonic antigen (CEA), carbohydrate antigen (CA)199, CA125, and Septin9 methylation, but inversely associated with ... Associations between Vitamin D and β-Cell Function and Colorectal Cancer-Associated Tumor Markers in Chinese Type 2 Diabetic ... in Chinese type 2 diabetes mellitus (T2DM) patients with albuminuria. ...
Handbook of Immunohistochemistry and in situ Hybridization of Human Carcinomas - 1st Edition
Purchase Handbook of Immunohistochemistry and in situ Hybridization of Human Carcinomas - 1st Edition. Print Book & E-Book. ... Carcinoembryonic Antigen, CA19-9 and DU-PAN-2 Glycoproteins CCND1 Cyclooxygenase-2 Glypican-3 Hepatitis B XAntigen HER-2/neu ... 7 Expression of Carbohydrate Antigens in Pancreatic Cancer Introduction Materials Immunohistochemistry Polymerase Chain ... Alteration of p73 Expression in Human Cancer Alteration of p63 Expression in Human Cancer Upstream Components That Signal to ...
Patent US6706693 - Vaccination by topical application of genetic vectors - Google Patents
... by applying to said skin an immunologically effective concentration of a vector encoding a gene which encodes an antigen which ... A carcinoembryonic antigen polynucleotide vaccine for human clinical use. Cancer Gene Ther. 2, 33-38 (1995). ... Representative examples of antigens which can be used to produce an immune response using the methods of the present invention ... an adenovirus vector encoding the human carcinoembryonic antigen (CEA)] was pipetted onto the skin of the C57BL/6 strain mice. ...
carcinoembryonic antigen related cell adhesion molecule 5 ELISA Kits | Biocompare.com
Compare carcinoembryonic antigen related cell adhesion molecule 5 ELISA Kits from leading suppliers on Biocompare. View ... The ELISA (enzyme-linked immunosorbent assay) is a well-established antibody-based tool for detecting and quantifying antigens ... Human Carcinoembryonic antigen-related cell adhesion molecule 5 ELISA Kit *. Detection Target: Carcinoembryonic antigen-related ... carcinoembryonic antigen related cell adhesion molecule 5 ELISA Kits. ...
Studies on effect of carcinoembryonic antigen on leucocyte migration inhibition test in patients with colorectal cancer |...
Carcinoembryonic antigen (CEA) is one of the best tumor markers for... ... is a useful method to detect tumor associated antigens (TAA) in cancer patients. ... Reisfeld RA, Pellegrino MA, Kahan BD: Salt extraction of soluble HL-A antigens. Science 172: 1134-1136, 1971PubMedCrossRef ... Clausen JE: Tuberculin-induced migration inhibition of human peripheral leucocytes in agarose medium. J Acta Allerg (Kbh) 26: ...
Type, Density, and Location of Immune Cells Within Human Colorectal Tumors Predict Clinical Outcome | Science
... carcinoembryonic antigen-related cell adhesion molecule 1; GLNY, granulysin; IRF1, interferon regulatory factor 1; TBX, T-box ... Tumor cells can express antigens and become targets for a T cell-mediated adaptive immune response (5, 6). The differentiation ... After antigen stimulation, a small population of antigen-specific memory T cells remains in the tissues (21). We recently ... The role of immune cells in human neoplasia is less clear (8). Immune cells can release inflammatory mediators with ...
CEACAM16 Gene - GeneCards | CEA16 Protein | CEA16 Antibody
Suggested Antigen Peptide Sequences for CEACAM16 Gene. GenScript: Design optimal peptide antigens:. *Carcinoembryonic antigen- ... Q2WEN9-CEA16_HUMAN. Recommended name:. Carcinoembryonic antigen-related cell adhesion molecule 16. Protein Accession:. Q2WEN9. ... Carcinoembryonic Antigen-Related Cell Adhesion Molecule 16 2 3 4 * Carcinoembryonic Antigen Related Cell Adhesion Molecule 16 2 ... Carcinoembryonic antigen-related cell adhesion molecule 16 interacts with alpha-tectorin and is mutated in autosomal dominant ...
Effective production of carcinoembryonic antigen by conversion of the membrane-bound into a recombinant secretory protein by...
... the most widely used human tumor marker, is a heavily glycosylated protein over-expressed by a wide range of tumors. It has ... Shively JE, Beatty JD: CEA-related antigens: molecular biology and clinical significance. Crit Rev Oncol Hematol 2: 355-399, ... Carcinoembryonic antigen (CEA), the most widely used human tumor marker, is a heavily glycosylated protein over-expressed by a ... Benchimol S, Fuks A, Jothy S, et al: Carcinoembryonic antigen, a human tumor marker, functions as an intercellular adhesion ...
Phase I Study of Immunization with Dendritic Cells Modified with Fowlpox Encoding Carcinoembryonic Antigen and Costimulatory...
Among the many tumor antigens described, the model antigen, carcinoembryonic antigen (CEA), is of particular interest because ... Immunotherapy with autologous, human dendritic cells transfected with carcinoembryonic antigen mRNA. Cancer Invest 2003;21:341- ... Identification of an enhancer agonist cytotoxic T lymphocyte peptide from human carcinoembryonic antigen. Cancer Res 1997;57: ... A phase I study of active immunotherapy with carcinoembryonic antigen peptide (CAP-1)-pulsed, autologous human cultured ...
Patent US5013645 - Immunological methods and materials for detection of tumor associated antigens - Google Patents
... are employed in immunoassays performed on patient body fluids and for purification of tumor-associated antigen compositions. ... Disclosed are immunological methods and materials for detection of antigens associated with breast or prostate cancer disease ... PR92 Antigen From DU145 Cell Extract. An alternate, non-human, source of PR92 antigen was developed from the soluble cell ... Also included were: prostate specific antigen (PA); carcinoembryonic antigen (CEA); alfa-fetoprotein; ferritin; blood group ...
Induction of Protective Host Immunity to Carcinoembryonic Antigen (CEA), a Self-Antigen in CEA Transgenic Mice, by Immunizing...
Gold P., Freedman S. O. Demonstration of tumor-specific antigens in human colonic carcinomata by immunological tolerance and ... Human carcinoembryonic antigen (CEA) is a well-characterized oncofetal glycoprotein whose overexpression by human carcinomas ... Cytotoxic T cell responses for human carcinoembryonic antigen (CEA) epitopes in mice transgenic for HLA-A2.1Kb and human CEA. ... Escherichia coli of human origin binds to carcinoembryonic antigen (CEA) and non-specific crossreacting antigen (NCA). FEBS ...
JCI - Volume 82, Issue 2
Release of carcinoembryonic antigen from human colon cancer cells by phosphatidylinositol-specific phospholipase C.. ... Consistent with our earlier observations, hybridoma antibodies specific for conventional antigens exhibited cross-reactivity ... Release of carcinoembryonic antigen from human colon cancer cells by phosphatidylinositol-specific phospholipase C.. ... Carcinoembryonic antigen (CEA) is released from colon cancer cells into the circulation where it is monitored clinically as an ...
Selectins and Associated Adhesion Proteins in Inflammatory disorders | SpringerLink
This glycoprotein was identified as carcinoembryonic antigen (CEA). CEA serves as an auxiliary L-selectin ligand, which ... The most common acute infection in humans, Human Rhinovirus (HRV) is a leading cause of exacerbations of asthma and chronic ... The most studied ligands for CAMs expressed on cancer cells, s-Lewisa and s-Lewisx antigens, are shown to be involved in ... Schnaar RL, Alves CS, Konstantopoulos K (2008) Carcinoembryonic antigen and CD44 variant isoforms cooperate to mediate colon ...
Patente US5788819 - Method for driving liquid, and method and apparatus for mixing and agitation ... - Google Patentes
and their antibodies; tumor labelled compounds such as carcinoembryonic antigen (CEA), prostatic acidic phosphatase (PAP), CA19 ... antigens (including recombinant antigen), antibodies, etc. Further, the biological substance which is particularly important in ... In this Example, a reaction cell having a filter sensitized to a human CRP antibody (IgG fraction) was set on a rubber sheet 25 ... Antigen-antibody reactions and hybridization tend to be affected by the pH of the solvent. Therefore, the pH buffering agent is ...
Synthesis of Carcinoembryonic Antigen in vitro | Nature New Biology
If this were the case, then human colonic cancer cells in long-term propagation in vitro should not synthesize this material. ... It has been proposed, however, that tumour-specific antigens such as CEA are not indigenous to the tumours, but are ... carcinoembryonic antigen (CEA), provides a suitable candidate for studying one such property related to a particular type of ... It therefore seems reasonable to expect that cell products such as tumour-associated antigens could, if present from the outset ...
Frontiers | Toward Maximizing Immunotherapy in Metastatic Castration-Resistant Prostate Cancer - Rationale for Combinatorial...
Prostate cancer is particularly suited for active immunotherapy because of the expression of a distinctive number of antigens ... Prostate cancer is particularly suited for active immunotherapy because of the expression of a distinctive number of antigens ... Another murine study immunized mice with implanted colon tumors expressing human carcinoembryonic antigen (CEA). The ... It also induced antigen-specific T-cell responses to tumor-derived antigens distinct from the antigen used in the vaccine (the ...
2019-nCoV Spike Protein (S1 Subunit, His Tag) (100 μg) - BioServUK
... carcinoembryonic antigen-related cell adhesion molecule 1; Sia, sialic acid; O-ac Sia, O-acetylated sialic acid. The spike is ... Its been reported that 2019-nCoV can infect the human respiratory epithelial cells through interaction with the human ACE2 ... SARS-CoV-1 Antigens. *Molecular Biology Research Tools. *RT-qPCR Detection Kits ... Activity: The 2019-nCoV Spike Protein (S1 Subunit, His Tag) can bind with Human ACE2 in functional ELISA assay.. Protein ...
Development of a highly sensitive device for counting the number of disease-specific exosomes in human sera<...
In addition to the ubiquitous exosome markers CD9 and CD63, the cancer-related antigens CD147, carcinoembryonic antigen, and ... In addition to the ubiquitous exosome markers CD9 and CD63, the cancer-related antigens CD147, carcinoembryonic antigen, and ... In addition to the ubiquitous exosome markers CD9 and CD63, the cancer-related antigens CD147, carcinoembryonic antigen, and ... In addition to the ubiquitous exosome markers CD9 and CD63, the cancer-related antigens CD147, carcinoembryonic antigen, and ...
Heterogeneity of human colon carcinoma<...
... and their secreted levels of carcinoembryonic antigen. These cell lines were later characterized based on cell surface proteins ... These cell lines were later characterized based on cell surface proteins and antigens detected with antisera raised against a ... and their secreted levels of carcinoembryonic antigen. These cell lines were later characterized based on cell surface proteins ... and their secreted levels of carcinoembryonic antigen. These cell lines were later characterized based on cell surface proteins ...
Recombinant (Sf9) Human Centromere Protein-B
Recombinant (Insect cells) Human Carcinoembryonic Antigen. > Recombinant (E.Coli) Human IP-10 (CXCL10), his Tag ... Mouse Anti-Hepatitis B Virus (HBsAg;AD & AY Antigens) IgG. > Recombinant (E.Coli, his tag) Human Ubiquitin Conjugating enzyme 7 ... Recombinant purified Mycobacterium Tuberculosis major secretory protein Antigen 85B (30 kda Antigen, Ag85b) ... Recombinant (E.Coli) Human C-terminal hemopexin-like domain of MMP-2 (445-635 a.a.) ...
Faculty Directory › UConn Health
Enhancing immunogenicity of a CTL epitope from carcinoembryonic antigen by selective amino acid replacements. Huarte, Eduardo; ... Global survey of human T leukemic cells by integrating proteomics and transcriptomics profiling. Wu L, Hwang S-I, Rezaul K, Lu ... Wang, X; Liang, B; Rebmann, V; Lu, J; Celis, E; Kageshita, T; Grosse-Wilde, H; Ferrone, S Tissue antigens 2003 Aug;62(2):139-48 ... Multiepitope Trojan antigen peptide vaccines for the induction of antitumor CTL and Th immune responses. Lu, Jun; Higashimoto, ...
Isotype: MIgG1, Positive Tested Species Reactivity: Goat, Mouse
On the nature of cancer and why anticancer vaccines don't work | Cancer Cell International | Full Text
A further problem is that an immune reaction against tumor antigens, especially in moderate or low amount, may be stimulatory ... The tissue-specific antigens involved in autoimmune reactions and the "carcino-embryonic antigens" are important realities, but ... Mellon I, Bohr VA, Smith CA, Hanawalt PC: Preferential DNA repair of an active gene in human cells. Proc Natl Acad Sci USA. ... The postulated, as well as demonstrated, paucity of antigen-producing mutations in the expressed genes of most cancers, plus ...
Positive Tested Species Reactivity: Goat, Rat, Recommended Applications: Function-Blocking, Immunofluorescence
Positive Tested Species Reactivity: Opossum, Rat, Recommended Applications: Immunofluorescence, Microarray
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Manufacturer,Supplier,Exporter of RotaAdeno virus 2 in 1 Rapid Test Strip from China. Contact us for more information of ... with gold particulates and is directed against the specific human genus-specific Rotavirus antigen or Adenovirus antigens. The ... Carcinoembryonic antigen test cassette. *Carcinoembryonic antigen test strip. *Coxsackie Virus A16 (CVA16)-IgM antibody ... At least 47 serotypes of adenovirus have been described till now, all sharing a common hexon antigen. Serotypes 40 and 41 are ...
Isotype: -kappa-light-chain, MIgG1, Positive Tested Species Reactivity: Bee, Mouse
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Carcino Embryonic Antigen CEAAntibodyTumorsAntibodiesEpidermal growth fSpecificityCross-reactinSignaling moleculesChimeric antigen receptorColon carcinomaReactivityProstate specifiCarcinomasProteinCD66eTumour-associatedImmunizationVitroGene familyCEACAM6Tumor markerInducePeptideGlycoproteinELISA KitSerumDigestive systemEpitopeMembrane ProteinsReceptorCharacterizationInducesEpithelial cellsFowlpoxMurineCellDetectionSolid tumorSecretoryCancersColonicVacciniaBindTissue distributionAnti-tumorClinicalReceptors
Carcino Embryonic Antigen CEA2
- Carcino Embryonic Antigen (CEA) is synthesised during development in the fetal gut, and is re-expressed in increased amounts in intestinal carcinomas and several other tumors. (abcam.com)
- IHC image of Carcino Embryonic Antigen CEA staining in human colon formalin fixed paraffin embedded tissue section, performed on a Leica Bond system using the standard protocol F. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH6, epitope retrieval solution 1) for 20 mins. (abcam.com)
- Samples and standards and are added to the wells, where Carcino Embryonic Antigen in the sample and standards binds to the precoated antibody. (abcam.com)
- Added Anti-Carcino Embryonic Antigen-HRP conjugate binds to the antibody-Carcino Embryonic Antigen complex. (abcam.com)
- An anti-human CD4 antibody (MAX.16H5) was applied intravenously in clinical trials for the treatment of autoimmune diseases (e.g., rheumatoid arthritis) and acute late-onset rejection after transplantation of a renal allograft. (frontiersin.org)
- However, as the possibility of developing immune reactions against the murine IgG 1 Fc-part remains, the murine antibody was chimerized, inheriting CD4-directed variable domains of the MAX.16H5 IgG 1 connected to a human IgG 4 backbone. (frontiersin.org)
- 4 )]. In this context, the human CD4 + T-cell clone 2C11 was generated ( 5 ) for immunization of BALB/c mice to produce the monoclonal anti-human CD4 antibody MAX.16H5 (initial name 30F16H5) ( 6 , 7 ). (frontiersin.org)
- The ELISA (enzyme-linked immunosorbent assay) is a well-established antibody-based tool for detecting and quantifying antigens of interest. (biocompare.com)
- Immunoadsorbent purification of carcinoembryonic antigen using a monoclonal antibody: a direct comparison with a conventional method. (springer.com)
- 5. A murine-derived hybridoma cell line ATCC HB 9390, wherein antibody produced by said cell line reacts with a tumor-associated antigen having a molecular weight of about 420,000 to about 520,000 daltons under non-reducing conditions. (google.com)
- In ELISA, the antibody reacts with CEA preparations from both colo-rectal carcinomas, lung andenocarcinomas and the colon carcinoma cell line LS 174T, whereas the antibody does not cross-react with isolated CEA-related antigens, e.g. (agilent.com)
- By simultaneously binding to tumor associated antigens (TAAs) and CD3Ɛ, The scFv antibody can retarget surrounding T cells to antigen-expressing tumor cells. (jcancer.org)
- In the majority of cases, the targeting moiety is an antibody [ 1 , 2 ] or antibody fragment [ 1 , 3 ] but equally it can also be another protein species or a non-protein chemical structure that recognizes and binds to a suitable target cell-specific surface molecule. (mdpi.com)
- The selection and characterization of human anti-CEA single-chain antibody fragments (scFv) is a first step toward the construction of new anticancer monoclonal antibodies designed for optimal blood clearance and tumor penetration. (biomedcentral.com)
- The human MA39 scFv, selected for its ability to recognize a CEA epitope expressed on human colon carcinomas, was first isolated from a large semi-synthetic ETH-2 antibody phage library, panned on human purified CEA protein. (biomedcentral.com)
- The scFv MA39 antibody was affinity-maturated by in vitro mutagenesis and the new scFv clone, E8, was isolated, typed for CEA family member recognition and its CEACAM1, 3 and 5 shared epitope characterized for expression in a large panel of human normal and tumor tissues and cells. (biomedcentral.com)
- The construction of libraries of recombinant antibody fragments that are displayed on the surface of filamentous phage, and the selection of phage antibodies against target antigens, have become an important technological tool in generating new monoclonal antibodies for research and clinical applications. (biomedcentral.com)
- Thus, naïve or semi-synthetic human antibody libraries can be used in the search for specific antibodies without immunization with respective antigens. (biomedcentral.com)
- This antibody recognizes human CEA protein in ELISA, Western blot and flow cytometry. (biomedcentral.com)
- For other IHC staining systems (automated and non-automated) customers should optimize variable parameters such as antigen retrieval conditions, primary antibody concentration and antibody incubation times. (abcam.com)
- Formalin fixed paraffin embedded human colon carcinoma stained with CEA antibody. (acris-antibodies.com)
- The registered numbers of clinical trials increase annually, and a range of tumor antigens, including CEA, mesothelin, HER2, and GD2, are being targeted for various solid tumors. (hindawi.com)
- Carcinoembryonic antigen (CEA), the most widely used human tumor marker, is a heavily glycosylated protein over-expressed by a wide range of tumors. (springer.com)
- To produce CEA with the same glycosylation pattern and immunogenicity as the native CEA expressed by human tumors in vivo , the truncated CEA cDNA which does not encode the last C-terminal 33-amino acid hydrophobic domain was transfected into HT29, a human colon carcinoma cell line by the calcium phosphate method. (springer.com)
- Efficient retroviral vector targeting of carcinoembryonic antigen positive tumors. (springer.com)
- The role of the adaptive immune response in controlling the growth and recurrence of human tumors has been controversial. (sciencemag.org)
- Recently, simian virus 40 (SV40) has been associated with human mesothelioma and brain and bone tumors (reviewed in refs. (pnas.org)
- A and B antigens of tumors arising from urinary epithelium. (pubmedcentralcanada.ca)
- Over-expression of CEA/CEACAM5 in tumors of epithelial origin is the basis of its wide-spread use as a tumor marker (2). (acris-antibodies.com)
- A 96-well plate has been precoated with anti-Carcino Embryonic Antigen antibodies. (abcam.com)
- Monoclonal antibodies targeting such antigens (other than the TCR or CD3) can therefore bind to several antigen-expressing cell types. (frontiersin.org)
- Humoral immunity involves antibodies that directly bind to antigens. (google.com)
- Epitope mapping of the carcinoembryonic antigen with various related recombinant proteins expressed in Chinese hamster ovary cells and 25 distinct monoclonal antibodies. (springer.com)
- PR92 monoclonal antibodies produced by hybridoma cell line ATCC HB 9390) are employed in immunoassays performed on patient body fluids and for purification of tumor-associated antigen compositions. (google.com)
- e) determining the extent to which labeled monoclonal antibodies are bound in said second reaction mixture, thereby detecting prostate or breast tumor-associated antigens in the fluid sample. (google.com)
- Specificity and affinity of monoclonal antibodies against carcinoembryonic antigen. (agilent.com)
- Bispecific scFv antibodies represent a successful and promising immunotherapy platform that retargets cytotoxic T cells to tumor cells, with one scFv directed to tumor-associated antigens and the other to T cells. (jcancer.org)
- Recombinant bispecific antibodies have also been intensively studied to retarget T cells against highly expressed tumor-associated antigens. (jcancer.org)
- Over 50 different formats of bispecific antibodies are now available for therapeutic and diagnostic applications [ 2 ]. (jcancer.org)
- Irrefutable evidence that an entirely immunologic approach can cause regression of a wide array of human cancers has come from the recent success of using monoclonal antibodies (mAbs) targeting checkpoints of immune activation, including cytotoxic T lymphocyte-associated protein 4 (CTLA-4) (ref. 1) and programmed cell death protein 1 (PD-1) (ref. 2). (investorvillage.com)
- In this system, individual exosomes were captured in the groove of an optical disc coated with antibodies against exosome surface antigens. (nih.gov)
- Human antibodies obtained by this method do not induce harmful immune response in patients, in comparison with murine monoclonal antibodies produced by the classic hybridoma techniques. (biomedcentral.com)
- Biothera has established extensive proof of concept and safety results for its lead asset in combination with anti-cancer antibodies and is pursuing additional clinical and translational research in 2016 prior to planned initiation of registration Phase 2/3 studies of Imprime PGG in 2017 - 18. (sachsforum.com)
Epidermal growth f1
- In addition to the ubiquitous exosome markers CD9 and CD63, the cancer-related antigens CD147, carcinoembryonic antigen, and human epidermal growth factor receptor 2 (HER2) were also used to quantify cancer cell line-derived exosomes. (nih.gov)
- Three distinct types of tumor antigens are considered to optimize specificity and safety in bispecific scFv based treatment: cancer-testis antigens, neo-antigens and virus-associated antigens. (jcancer.org)
- This interaction is exclusively relies on TAAs and CD3Ɛ while completely independent of peptide/MHC complex and the antigen specificity of bound T cells [ 5 - 8 ]. (jcancer.org)
- Gene engineering obviates the requirement for surgery because T cells can be isolated from the blood and receptors conveying specificity for tumor-associated antigens can be introduced using viral and non-viral integration techniques22. (investorvillage.com)
- These alternative platforms differ in their antigen profiles, sensitivity and specificity, raising uncertainties regarding standardisation and interpretation of incongruent results. (diva-portal.org)
- Expression of complementary DNA and genomic clones for carcinoembryonic antigen and nonspecific cross-reacting antigen in Chinese hamster ovary and mouse fibroblast cells and characterization of the membrane-expressed products. (springer.com)
- Specific primer sets were designed for CEA, non-specific cross-reacting antigen (NCA), biliary glycoprotein (BGP), carcinoembryonic antigen gene-family members 1, 6 and 7 (CGMI, CGM6 and CGM7), and one set for all pregnancy-specific glycoprotein (PSG) transcripts. (uni-muenchen.de)
- Links Chi, K., Jessup, J. M. and Frazier, M. L., Predominant expression of mRNA coding for non-specific cross-reacting antigen in colorectal carcinomas. (uni-muenchen.de)
- These cells could directly recognize tumor cells by genetic modification to express a chimeric antigen receptor (CAR), and they were activated to exhibit a durable persistence in vivo through the T-cell activation endodomain with costimulatory signaling molecules [ 1 , 2 ]. (hindawi.com)
Chimeric antigen receptor4
- Recent studies have highlighted the successes of chimeric antigen receptor-modified T- (CART-) cell-based therapy for B-cell malignancies, and early phase clinical trials have been launched in recent years. (hindawi.com)
- Recently, chimeric antigen receptor-modified T- (CART-) cell-based therapy, an innovative approach to tumor treatment, was demonstrated to potentially exhibit MHC-independent antitumor effects. (hindawi.com)
- Current status of clinical trials of chimeric antigen receptor-modified T (CART) cells in malignancies. (hindawi.com)
- These include adoptive cell therapies, such as chimeric antigen receptor (CAR) T cells, genetically engineered TCR-T cells, and tumor-infiltrating lymphocytes (TILs). (jcancer.org)
- Matzku S, Zöller M, Schulz U, Deltze W, Barth HO, Saeger HD, Price MR: Lack of correlation between carcinoembryonic antigen content of tumor extracts and leucocyte migration reactivity of tumor patients. (springer.com)
- TILs demonstrate tumor reactivity with variable frequency in a range of cancers, including melanoma14-17, GI18,19, lung20 and human papilloma virus-associated malignancies21. (investorvillage.com)
- An expression library of 3,559 human plasma membrane proteins was screened for reactivity with Hom-1 virus-like particles, and a single interacting protein, human junctional adhesion molecule 1 (hJAM1), was identified. (asm.org)
- These include the mucins MUC-1, 2, Globo H, GM-2, prostate stem cell antigen (PSCA), prostate specific antigen (PSA), and prostate specific membrane antigen (PSMA). (frontiersin.org)
- We present a randomized phase II clinical trial designed to determine if a poxviral vaccine encoding prostate-specific antigen (PSA) can induce a PSA-specific T-cell response when combined with radiotherapy in patients with clinically localized prostate cancer. (aacrjournals.org)
- Human carcinoembryonic antigen (CEA) is a well-characterized oncofetal glycoprotein whose overexpression by human carcinomas has been a target for cancer immunotherapy. (aacrjournals.org)
- Blood group substances (BG) as carcinofetal antigens in carcinomas of the distal colon. (pubmedcentralcanada.ca)
- This new immunoreagent meets all criteria for a potential anticancer compound: it is human, hence poorly or not at all immunogenic, and it binds selectively and with good affinity to the CEA epitope expressed by metastatic melanoma and colon and lung carcinomas. (biomedcentral.com)
- and, wherein said protein comprises an antigen or immunogenic fragment thereof. (google.com)
- In a multi-purpose research program to provide a reliable source for large production of CEA, we converted the membrane-bound carcinoembryonic antigen into a secretory protein by site-specific mutagenesis. (springer.com)
- It is predicted that human cancer immunotherapy using recombinant CEA expressed in this system would be more effective than the commercial protein which is usually prepared from bacterial or other heterologous expression systems. (springer.com)
- Because of the crucial role of dendritic cells in adaptive immunity and their potent activity in animal tumor models, numerous pilot studies have evaluated immunotherapy with dendritic cells loaded with antigen in the form of peptide, protein, DNA, mRNA, tumor lysates, tumor fusions, and viral vectors ( 1 ). (aacrjournals.org)
- A variant of signal regulatory protein alpha (SIRPa) that antagonizes the human cell surface antigen CD47, with potential phagocytosis-inducing, immunostimulating and antineoplastic activities. (cancer.gov)
- CD47, also called integrin-associated protein (IAP), is a tumor-associated antigen (TAA) expressed on normal, healthy hematopoietic stem cells (HSC) and overexpressed on the surface of a variety of cancer cells. (cancer.gov)
- Protein crystallization has three major applications: (1) structural biology and drug design, (2) bioseparations, and (3) purification. (google.com)
- Taken together, our data indicate that entry of the Hom-1 vesivirus into these permissive human cell lines is mediated by the plasma membrane protein hJAM1 as a functional receptor. (asm.org)
- Get higher sensitivity in only 90 minutes with Human Carcinoembryonic Antigen ELISA Kit (CD66e) ( ab183365 ) from our SimpleStep ELISA ® range. (abcam.com)
- It therefore seems reasonable to expect that cell products such as tumour-associated antigens could, if present from the outset, be retained in a demonstrable state when the tumour cells are cultivated outside the original host organism. (nature.com)
- Carrel S, Theilkaes L. Evidence for a tumour-associated antigen in human malignant melanoma. (pubmedcentralcanada.ca)
- Invernizzi G, Parmiani G. Tumour-associated transplantation antigens of chemically induced sarcomata cross reacting with allogeneic histocompatibility antigens. (pubmedcentralcanada.ca)
- The results demonstrate the ability to generate an effective antitumor immune response to a tumor self-antigen by immunization with a recombinant vaccinia virus. (aacrjournals.org)
- Abcam's Carcino Embryonic Antigen in vitro ELISA (Enzyme-Linked Immunosorbent Assay) kit is designed for the accurate quantitative measurement of Carcino Embryonic Antigen in Human serum. (abcam.com)
- If this were the case, then human colonic cancer cells in long-term propagation in vitro should not synthesize this material. (nature.com)
- Deregulated expression of the human tumor marker CEA and CEA family member CEACAM6 disrupts tissue architecture and blocks colonocyte differentiation. (springer.com)
- The results suggest that some antigens which induce leucocyte migration inhibition factor ( LMIF ) to lymphocytes from colorectal cancer patients might be different substances from CEA. (springer.com)
- The first is peptide antigen presented via MHC binding to the T-cell receptor. (aacrjournals.org)
- It encodes a glycosyl phosphatidyl inositol (GPI)-linked glycoprotein with a Mr of 90,000 which is strongly expressed on epithelial cells of the fetal and adult gastrointestinal tract, epithelia of glandular tissues, squamous epithelial cell of the tongue, esophagus and cervix as well as on granulocytes (Fig. 2 Ref. 4, 10). (antibodies-online.com)
- I: Primary structure of a glycoprotein immunologically cross-reactive with carcinoembryonic antigen. (uni-muenchen.de)
- Your search returned 120 carcinoembryonic antigen related cell adhesion molecule 5 ELISA ELISA Kit across 18 suppliers. (biocompare.com)
- This study is to investigate the protective effects of vitamin D in T2DM, as well as the associations between serum calcifediol level and β-cell function, and risk of CRC, in Chinese type 2 diabetes mellitus (T2DM) patients with albuminuria. (nih.gov)
- 2. The method of claim 1 wherein the body fluid sample analyzed is a serum sample. (google.com)
- We showed that the ExoCounter could detect specific exosomes derived from cells or human serum without any enrichment procedures. (nih.gov)
- The detection of carcinoembryonic antigen in whole serum from patients with malignant and nonmalignant disease. (pubmedcentralcanada.ca)
- The discovery by Gold and Freedman 2 of an antigenic substance specific for entodermally-derived cancers of the digestive system, carcinoembryonic antigen (CEA), provides a suitable candidate for studying one such property related to a particular type of human cancer. (nature.com)
- Specific carcinoembryonic antigens of the human digestive system. (pubmedcentralcanada.ca)
- Monoclonal Mouse Anti-Human Carcinoembryonic Antigen (CEA), Clone II-7, belongs to epitope group GOLD 1 (8). (agilent.com)
- The binding affinity of the scFv E8 is in a range for efficient, in vivo , antigen capture in tumor cells expressing a shared epitope of the CEACAM1, 3 and 5 proteins. (biomedcentral.com)
- Screening of a library of human cell surface membrane proteins showed that the virus could utilize human junctional adhesion molecule 1 as a receptor to enter cells and initiate replication. (asm.org)
- Besides the T cell receptor (TCR) and the CD3 antigen, other molecules are expressed on T cells but are also present on other hematopoietic cells ( 1 ). (frontiersin.org)
- It acts as a co-receptor during antigen presentation and associates with the TCR upon major histocompatibility complex (MHC) binding ( 1 , 2 ). (frontiersin.org)
- Receptor-engineered T cells have the potential to cause lethal toxicity from on-target recognition of normal tissues, and there is a paucity of truly tumor-specific antigens shared across tumor types. (investorvillage.com)
- Gammaretroviral and lentiviral vectors have been used most commonly in antigen receptor gene therapy trials. (investorvillage.com)
- Elting, J. J. : Carcinoembryonic antigen family: characterization of cDNAs coding for NCA and CEA and suggestion of nonrandom sequence variation in their conserved loop-domains. (acris-antibodies.com)
- Also provided is a method of inducing an anti-tumor immune response in an animal in need of such treatment, comprising the step of: contacting skin of said animal topically by applying to said skin an immunologically effective concentration of a vector encoding a gene which encodes an antigen which induces an anti-tumor effect in said animal following administration. (google.com)
- Gangopadhyay A, Bajenova O, Kelly TM, Thomas P: Carcinoembryonic antigen induces cytokine expression in Kuppfer cells: implications for hepatic metastasis from colorectal cancer. (exbio.cz)
- Muenzner, Rohde, Kneitz, Hauck: CEACAM engagement by human pathogens enhances cell adhesion and counteracts bacteria-induced detachment of epithelial cells. (antibodies-online.com)
- Because PSA is expressed essentially only in prostatic epithelial cells (normal and malignant), and the prostate gland is nonessential, this antigen is an enticing choice. (aacrjournals.org)
- 180-200 kDa), an extracellular cell surface-bound carcinoembryonic antigen mainly expressed on epithelial cells. (exbio.cz)
- In this phase I study, we administered one or two cycles of four triweekly s.c./intradermal injections of ex vivo generated dendritic cells modified with a recombinant fowlpox vector encoding carcinoembryonic antigen (CEA) and a triad of costimulatory molecules [rF-CEA(6D)-TRICOM]. (aacrjournals.org)
- Both have been engineered to express tumor antigen, such as CEA, and have been tested in murine ( 10 ) and human ( 11 , 12 ) studies. (aacrjournals.org)
- Professor Utz is an expert in the study of human and murine autoantibodies and autoantigens, apoptosis signaling pathways, animal models of autoimmunity, proteomics and multiplexed assay development for biomarker discovery. (stanford.edu)
- To determine the safety and immunologic and clinical efficacy of a dendritic cell vaccine modified to hyperexpress costimulatory molecules and tumor antigen. (aacrjournals.org)
- ref. 2 ) and with the mRNA encoding CEA ( 3 ) and measured low frequencies of CEA-specific T-cell responses in a few patients. (aacrjournals.org)
- Prostate cancer is particularly suited for active immunotherapy because of the expression of a distinctive number of antigens which are overexpressed on prostate cancer cells and cell lines. (frontiersin.org)
- First, there are a several altered self-antigens, glycoproteins, and glycolipids, which are overexpressed or underglycosylated on prostate cancer cells and cell lines ( Slovin, 2008 ). (frontiersin.org)
- The ExoCounter system exhibits high performance in the direct detection of exosomes in cell culture and human sera. (nih.gov)
- Human cells are termed semipermissive because only a fraction of cells express SV40 Tag after infection, these infected cells are lysed, and cell transformation is a very rare event. (pnas.org)
- A proprietary agent that targets the cancer stem cell (CSC) antigen CD44, with potential antineoplastic activity. (cancer.gov)
- Colorectal cancer cell lines (Human). (abcam.com)
- CEA-related cell adhesion molecules (CEACAM) belong to the carcinoembryonic antigen (CEA) family (1). (acris-antibodies.com)
- Cell lines of human origin were tested for growth of Hom-1, and efficient replication was observed in HepG2, HuH7, and SK-CO15 cells. (asm.org)
- In this study, we found that Hom-1 could be propagated in a number of human cell lines, making it the first calicivirus to replicate efficiently in cultured human cells. (asm.org)
- Emmrich F, Irmscher J, Kotzsch M, Müller M, Ambrosius H: Leucocyte migration inhibition under agarose versus MEM test for detection of tumor associated antigens. (springer.com)
- Disclosed are immunological methods and materials for detection of antigens associated with breast or prostate cancer disease states. (google.com)
- Recent published clinical studies on CART cells specific for solid tumor antigens. (hindawi.com)
- Results also aid in the classification of secretory meningiomas (2) and medullary carcinoma of the thyroid (3). (agilent.com)
- We characterized the tumor-infiltrating immune cells in large cohorts of human colorectal cancers by gene expression profiling and in situ immunohistochemical staining. (sciencemag.org)
- This success has captured public imagination and driven academic and industrial researchers to develop similar 'off-the-shelf' receptors targeting shared antigens on epithelial cancers, the leading cause of cancer-related deaths. (investorvillage.com)
- Release of carcinoembryonic antigen from human tumor cells by phosphatidylinositol-specific phospholipase C: highly effective extraction and upregulation from LS-174T colonic adenocarcinoma cells. (springer.com)
- Freedman, S. O. : Demonstration of tumor-specific antigens in human colonic carcinomata by immunological tolerance and absorption techniques. (acris-antibodies.com)
- Garrido F, Schirrmacher V, Festenstein H. H-2-like specificities of foreign haplotypes appearing on a mouse sarcoma after vaccinia virus infection. (pubmedcentralcanada.ca)
- One scFv domain is designed to recognize CD3Ɛ on T cells, whereas the other scFv is selected to bind tumor associated antigens. (jcancer.org)
- Transgenic mice that express CEA as a self-antigen with a tissue distribution similar to that of humans have been developed. (aacrjournals.org)
- It has been indicated that CEA might be a useful target for human anti-tumor immunotherapy. (springer.com)
- Human auto-immune thyroiditis: clinical studies. (pubmedcentralcanada.ca)
- Despite concerns about the possibility of insertional mutagenesis24, introduction of antigen receptors into mature human T cells has been used to treat several hundred patients without evidence of clonal expansion or transformation25. (investorvillage.com)