Apoptosis: One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.Caspases: A family of intracellular CYSTEINE ENDOPEPTIDASES that play a role in regulating INFLAMMATION and APOPTOSIS. They specifically cleave peptides at a CYSTEINE amino acid that follows an ASPARTIC ACID residue. Caspases are activated by proteolytic cleavage of a precursor form to yield large and small subunits that form the enzyme. Since the cleavage site within precursors matches the specificity of caspases, sequential activation of precursors by activated caspases can occur.Caspase 3: A short pro-domain caspase that plays an effector role in APOPTOSIS. It is activated by INITIATOR CASPASES such as CASPASE 9. Isoforms of this protein exist due to multiple alternative splicing of its MESSENGER RNA.DNA Fragmentation: Splitting the DNA into shorter pieces by endonucleolytic DNA CLEAVAGE at multiple sites. It includes the internucleosomal DNA fragmentation, which along with chromatin condensation, are considered to be the hallmarks of APOPTOSIS.In Situ Nick-End Labeling: An in situ method for detecting areas of DNA which are nicked during APOPTOSIS. Terminal deoxynucleotidyl transferase is used to add labeled dUTP, in a template-independent manner, to the 3 prime OH ends of either single- or double-stranded DNA. The terminal deoxynucleotidyl transferase nick end labeling, or TUNEL, assay labels apoptosis on a single-cell level, making it more sensitive than agarose gel electrophoresis for analysis of DNA FRAGMENTATION.Proto-Oncogene Proteins c-bcl-2: Membrane proteins encoded by the BCL-2 GENES and serving as potent inhibitors of cell death by APOPTOSIS. The proteins are found on mitochondrial, microsomal, and NUCLEAR MEMBRANE sites within many cell types. Overexpression of bcl-2 proteins, due to a translocation of the gene, is associated with follicular lymphoma.bcl-2-Associated X Protein: A member of the Bcl-2 protein family and homologous partner of C-BCL-2 PROTO-ONCOGENE PROTEIN. It regulates the release of CYTOCHROME C and APOPTOSIS INDUCING FACTOR from the MITOCHONDRIA. Several isoforms of BCL2-associated X protein occur due to ALTERNATIVE SPLICING of the mRNA for this protein.Antigens, CD95: A tumor necrosis factor receptor subtype found in a variety of tissues and on activated LYMPHOCYTES. It has specificity for FAS LIGAND and plays a role in regulation of peripheral immune responses and APOPTOSIS. Multiple isoforms of the protein exist due to multiple ALTERNATIVE SPLICING. The activated receptor signals via a conserved death domain that associates with specific TNF RECEPTOR-ASSOCIATED FACTORS in the CYTOPLASM.Phagocytosis: The engulfing and degradation of microorganisms; other cells that are dead, dying, or pathogenic; and foreign particles by phagocytic cells (PHAGOCYTES).Caspase Inhibitors: Endogenous and exogenous compounds and that either inhibit CASPASES or prevent their activation.Caspase 9: A long pro-domain caspase that contains a caspase recruitment domain in its pro-domain region. Caspase 9 is activated during cell stress by mitochondria-derived proapoptotic factors and by CARD SIGNALING ADAPTOR PROTEINS such as APOPTOTIC PROTEASE-ACTIVATING FACTOR 1. It activates APOPTOSIS by cleaving and activating EFFECTOR CASPASES.Apoptotic Protease-Activating Factor 1: A CARD signaling adaptor protein that plays a role in the mitochondria-stimulated apoptosis (APOPTOSIS, INTRINSIC PATHWAY). It binds to CYTOCHROME C in the CYTOSOL to form an APOPTOSOMAL PROTEIN COMPLEX and activates INITIATOR CASPASES such as CASPASE 9.Cell Survival: The span of viability of a cell characterized by the capacity to perform certain functions such as metabolism, growth, reproduction, some form of responsiveness, and adaptability.Mitochondria: Semiautonomous, self-reproducing organelles that occur in the cytoplasm of all cells of most, but not all, eukaryotes. Each mitochondrion is surrounded by a double limiting membrane. The inner membrane is highly invaginated, and its projections are called cristae. Mitochondria are the sites of the reactions of oxidative phosphorylation, which result in the formation of ATP. They contain distinctive RIBOSOMES, transfer RNAs (RNA, TRANSFER); AMINO ACYL T RNA SYNTHETASES; and elongation and termination factors. Mitochondria depend upon genes within the nucleus of the cells in which they reside for many essential messenger RNAs (RNA, MESSENGER). Mitochondria are believed to have arisen from aerobic bacteria that established a symbiotic relationship with primitive protoeukaryotes. (King & Stansfield, A Dictionary of Genetics, 4th ed)Annexin A5: A protein of the annexin family isolated from human PLACENTA and other tissues. It inhibits cytosolic PHOSPHOLIPASE A2, and displays anticoagulant activity.Cell Line, Tumor: A cell line derived from cultured tumor cells.Necrosis: The pathological process occurring in cells that are dying from irreparable injuries. It is caused by the progressive, uncontrolled action of degradative ENZYMES, leading to MITOCHONDRIAL SWELLING, nuclear flocculation, and cell lysis. It is distinct it from APOPTOSIS, which is a normal, regulated cellular process.Jurkat Cells: A CELL LINE derived from human T-CELL LEUKEMIA and used to determine the mechanism of differential susceptibility to anti-cancer drugs and radiation.Apoptosis Regulatory Proteins: A large group of proteins that control APOPTOSIS. This family of proteins includes many ONCOGENE PROTEINS as well as a wide variety of classes of INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS such as CASPASES.Signal Transduction: The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.Cytochromes c: Cytochromes of the c type that are found in eukaryotic MITOCHONDRIA. They serve as redox intermediates that accept electrons from MITOCHONDRIAL ELECTRON TRANSPORT COMPLEX III and transfer them to MITOCHONDRIAL ELECTRON TRANSPORT COMPLEX IV.Caspase 8: A long pro-domain caspase that contains a death effector domain in its pro-domain region. Caspase 8 plays a role in APOPTOSIS by cleaving and activating EFFECTOR CASPASES. Activation of this enzyme can occur via the interaction of its N-terminal death effector domain with DEATH DOMAIN RECEPTOR SIGNALING ADAPTOR PROTEINS.Phosphatidylserines: Derivatives of phosphatidic acids in which the phosphoric acid is bound in ester linkage to a serine moiety. Complete hydrolysis yields 1 mole of glycerol, phosphoric acid and serine and 2 moles of fatty acids.Cells, Cultured: Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.Cell Death: The termination of the cell's ability to carry out vital functions such as metabolism, growth, reproduction, responsiveness, and adaptability.Fas Ligand Protein: A transmembrane protein belonging to the tumor necrosis factor superfamily that was originally discovered on cells of the lymphoid-myeloid lineage, including activated T-LYMPHOCYTES and NATURAL KILLER CELLS. It plays an important role in immune homeostasis and cell-mediated toxicity by binding to the FAS RECEPTOR and triggering APOPTOSIS.Enzyme Activation: Conversion of an inactive form of an enzyme to one possessing metabolic activity. It includes 1, activation by ions (activators); 2, activation by cofactors (coenzymes); and 3, conversion of an enzyme precursor (proenzyme or zymogen) to an active enzyme.Tumor Suppressor Protein p53: Nuclear phosphoprotein encoded by the p53 gene (GENES, P53) whose normal function is to control CELL PROLIFERATION and APOPTOSIS. A mutant or absent p53 protein has been found in LEUKEMIA; OSTEOSARCOMA; LUNG CANCER; and COLORECTAL CANCER.bcl-X Protein: A member of the bcl-2 protein family that plays a role in the regulation of APOPTOSIS. Two major isoforms of the protein exist due to ALTERNATIVE SPLICING of the BCL2L1 mRNA and are referred to as Bcl-XS and Bcl-XL.Flow Cytometry: Technique using an instrument system for making, processing, and displaying one or more measurements on individual cells obtained from a cell suspension. Cells are usually stained with one or more fluorescent dyes specific to cell components of interest, e.g., DNA, and fluorescence of each cell is measured as it rapidly transverses the excitation beam (laser or mercury arc lamp). Fluorescence provides a quantitative measure of various biochemical and biophysical properties of the cell, as well as a basis for cell sorting. Other measurable optical parameters include light absorption and light scattering, the latter being applicable to the measurement of cell size, shape, density, granularity, and stain uptake.Tumor Cells, Cultured: Cells grown in vitro from neoplastic tissue. If they can be established as a TUMOR CELL LINE, they can be propagated in cell culture indefinitely.Cysteine Proteinase Inhibitors: Exogenous and endogenous compounds which inhibit CYSTEINE ENDOPEPTIDASES.Amino Acid Chloromethyl Ketones: Inhibitors of SERINE ENDOPEPTIDASES and sulfhydryl group-containing enzymes. They act as alkylating agents and are known to interfere in the translation process.Cell Line: Established cell cultures that have the potential to propagate indefinitely.Poly(ADP-ribose) Polymerases: Enzymes that catalyze the transfer of multiple ADP-RIBOSE groups from nicotinamide-adenine dinucleotide (NAD) onto protein targets, thus building up a linear or branched homopolymer of repeating ADP-ribose units i.e., POLY ADENOSINE DIPHOSPHATE RIBOSE.Blotting, Western: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.Proto-Oncogene Proteins: Products of proto-oncogenes. Normally they do not have oncogenic or transforming properties, but are involved in the regulation or differentiation of cell growth. They often have protein kinase activity.Caspase 7: A short pro-domain caspase that plays an effector role in APOPTOSIS. It is activated by INITIATOR CASPASES such as CASPASE 3 and CASPASE 10. Several isoforms of this protein exist due to multiple alternative splicing of its MESSENGER RNA.Staurosporine: An indolocarbazole that is a potent PROTEIN KINASE C inhibitor which enhances cAMP-mediated responses in human neuroblastoma cells. (Biochem Biophys Res Commun 1995;214(3):1114-20)Macrophages: The relatively long-lived phagocytic cell of mammalian tissues that are derived from blood MONOCYTES. Main types are PERITONEAL MACROPHAGES; ALVEOLAR MACROPHAGES; HISTIOCYTES; KUPFFER CELLS of the liver; and OSTEOCLASTS. They may further differentiate within chronic inflammatory lesions to EPITHELIOID CELLS or may fuse to form FOREIGN BODY GIANT CELLS or LANGHANS GIANT CELLS. (from The Dictionary of Cell Biology, Lackie and Dow, 3rd ed.)Cytochrome c Group: A group of cytochromes with covalent thioether linkages between either or both of the vinyl side chains of protoheme and the protein. (Enzyme Nomenclature, 1992, p539)Mice, Inbred C57BLMembrane Potential, Mitochondrial: The voltage difference, normally maintained at approximately -180mV, across the INNER MITOCHONDRIAL MEMBRANE, by a net movement of positive charge across the membrane. It is a major component of the PROTON MOTIVE FORCE in MITOCHONDRIA used to drive the synthesis of ATP.Caspase 2: A long pro-domain caspase that contains a caspase recruitment domain in its pro-domain region. Activation of this enzyme can occur via the interaction of its caspase recruitment domain with CARD SIGNALING ADAPTOR PROTEINS. Caspase 2 plays a role in APOPTOSIS by cleaving and activating effector pro-caspases. Several isoforms of this protein exist due to multiple alternative splicing of its MESSENGER RNA.Caspase 6: A short pro-domain caspase that plays an effector role in APOPTOSIS. It is activated by INITIATOR CASPASES such as CASPASE 7; CASPASE 8; and CASPASE 10. Isoforms of this protein exist due to multiple alternative splicing of its MESSENGER RNA.Cell Proliferation: All of the processes involved in increasing CELL NUMBER including CELL DIVISION.Reactive Oxygen Species: Molecules or ions formed by the incomplete one-electron reduction of oxygen. These reactive oxygen intermediates include SINGLET OXYGEN; SUPEROXIDES; PEROXIDES; HYDROXYL RADICAL; and HYPOCHLOROUS ACID. They contribute to the microbicidal activity of PHAGOCYTES, regulation of signal transduction and gene expression, and the oxidative damage to NUCLEIC ACIDS; PROTEINS; and LIPIDS.Enzyme Inhibitors: Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction.Antineoplastic Agents: Substances that inhibit or prevent the proliferation of NEOPLASMS.bcl-2 Homologous Antagonist-Killer Protein: A multi-domain mitochondrial membrane protein and member of the bcl-2 Protein family. Bak protein interacts with TUMOR SUPPRESSOR PROTEIN P53 and promotes APOPTOSIS.Time Factors: Elements of limited time intervals, contributing to particular results or situations.BH3 Interacting Domain Death Agonist Protein: A member of the Bcl-2 protein family that reversibly binds MEMBRANES. It is a pro-apoptotic protein that is activated by caspase cleavage.HL-60 Cells: A promyelocytic cell line derived from a patient with ACUTE PROMYELOCYTIC LEUKEMIA. HL-60 cells lack specific markers for LYMPHOID CELLS but express surface receptors for FC FRAGMENTS and COMPLEMENT SYSTEM PROTEINS. They also exhibit phagocytic activity and responsiveness to chemotactic stimuli. (From Hay et al., American Type Culture Collection, 7th ed, pp127-8)Cell Cycle: The complex series of phenomena, occurring between the end of one CELL DIVISION and the end of the next, by which cellular material is duplicated and then divided between two daughter cells. The cell cycle includes INTERPHASE, which includes G0 PHASE; G1 PHASE; S PHASE; and G2 PHASE, and CELL DIVISION PHASE.Genes, bcl-2: The B-cell leukemia/lymphoma-2 genes, responsible for blocking apoptosis in normal cells, and associated with follicular lymphoma when overexpressed. Overexpression results from the t(14;18) translocation. The human c-bcl-2 gene is located at 18q24 on the long arm of chromosome 18.Cell Division: The fission of a CELL. It includes CYTOKINESIS, when the CYTOPLASM of a cell is divided, and CELL NUCLEUS DIVISION.Immunohistochemistry: Histochemical localization of immunoreactive substances using labeled antibodies as reagents.DNA Damage: Injuries to DNA that introduce deviations from its normal, intact structure and which may, if left unrepaired, result in a MUTATION or a block of DNA REPLICATION. These deviations may be caused by physical or chemical agents and occur by natural or unnatural, introduced circumstances. They include the introduction of illegitimate bases during replication or by deamination or other modification of bases; the loss of a base from the DNA backbone leaving an abasic site; single-strand breaks; double strand breaks; and intrastrand (PYRIMIDINE DIMERS) or interstrand crosslinking. Damage can often be repaired (DNA REPAIR). If the damage is extensive, it can induce APOPTOSIS.Inhibitor of Apoptosis Proteins: A conserved class of proteins that control APOPTOSIS in both VERTEBRATES and INVERTEBRATES. IAP proteins interact with and inhibit CASPASES, and they function as ANTI-APOPTOTIC PROTEINS. The protein class is defined by an approximately 80-amino acid motif called the baculoviral inhibitor of apoptosis repeat.Dose-Response Relationship, Drug: The relationship between the dose of an administered drug and the response of the organism to the drug.Mice, Knockout: Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.Transfection: The uptake of naked or purified DNA by CELLS, usually meaning the process as it occurs in eukaryotic cells. It is analogous to bacterial transformation (TRANSFORMATION, BACTERIAL) and both are routinely employed in GENE TRANSFER TECHNIQUES.Tumor Necrosis Factor-alpha: Serum glycoprotein produced by activated MACROPHAGES and other mammalian MONONUCLEAR LEUKOCYTES. It has necrotizing activity against tumor cell lines and increases ability to reject tumor transplants. Also known as TNF-alpha, it is only 30% homologous to TNF-beta (LYMPHOTOXIN), but they share TNF RECEPTORS.Apoptosis Inducing Factor: A flavoprotein that functions as a powerful antioxidant in the MITOCHONDRIA and promotes APOPTOSIS when released from the mitochondria. In mammalian cells AIF is released in response to pro-apoptotic protein members of the bcl-2 protein family. It translocates to the CELL NUCLEUS and binds DNA to stimulate CASPASE-independent CHROMATIN condensation.HeLa Cells: The first continuously cultured human malignant CELL LINE, derived from the cervical carcinoma of Henrietta Lacks. These cells are used for VIRUS CULTIVATION and antitumor drug screening assays.Antineoplastic Agents, Phytogenic: Agents obtained from higher plants that have demonstrable cytostatic or antineoplastic activity.TNF-Related Apoptosis-Inducing Ligand: A transmembrane-protein belonging to the TNF family of intercellular signaling proteins. It is a widely expressed ligand that activates APOPTOSIS by binding to TNF-RELATED APOPTOSIS-INDUCING LIGAND RECEPTORS. The membrane-bound form of the protein can be cleaved by specific CYSTEINE ENDOPEPTIDASES to form a soluble ligand form.bcl-Associated Death Protein: A pro-apoptotic protein and member of the Bcl-2 protein family that is regulated by PHOSPHORYLATION. Unphosphorylated Bad protein inhibits the activity of BCL-XL PROTEIN.Down-Regulation: A negative regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins.Membrane Glycoproteins: Glycoproteins found on the membrane or surface of cells.Cell Nucleus: Within a eukaryotic cell, a membrane-limited body which contains chromosomes and one or more nucleoli (CELL NUCLEOLUS). The nuclear membrane consists of a double unit-type membrane which is perforated by a number of pores; the outermost membrane is continuous with the ENDOPLASMIC RETICULUM. A cell may contain more than one nucleus. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)Propidium: Quaternary ammonium analog of ethidium; an intercalating dye with a specific affinity to certain forms of DNA and, used as diiodide, to separate them in density gradients; also forms fluorescent complexes with cholinesterase which it inhibits.RNA, Messenger: RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Human BAG1 genome location and BAG1 gene details page in the UCSC Genome Browser. Tang SC (2003). "BAG-1, an anti-apoptotic ... It enhances the anti-apoptotic effects of BCL2 and represents a link between growth factor receptors and anti-apoptotic ... 1996). "Cloning of cDNAs encoding the human BAG1 protein and localization of the human BAG1 gene to chromosome 9p12". Genomics ... 1998). "p53-inducible human homologue of Drosophila seven in absentia (Siah) inhibits cell growth: suppression by BAG-1". EMBO ...
FMR1-AS1 has an anti-apoptotic function. Long noncoding RNA GRCh38: Ensembl release 89: ENSG00000268066 - Ensembl, May 2017 " ... "Human PubMed Reference:". Ladd PD, Smith LE, Rabaia NA, Moore JM, Georges SA, Hansen RS, et al. (2007). "An antisense ...
Sterile alpha motif and leucine zipper containing kinase AZK, also known as ZAK, is a human gene. This gene is a member of the ... The protein also has pro-apoptotic activity. Alternate transcriptional splice variants, encoding different isoforms, have been ... 2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci ... 2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724-31. doi:10.1038/ ...
In human cardiac tissue, this gene was found to affect cell growth and death while in neural tissue it affected neuronal growth ... 2004). "IRAS is an anti-apoptotic protein". Ann. N. Y. Acad. Sci. 1009: 400-12. doi:10.1196/annals.1304.054. PMID 15028619. ... In humans, this protein has been shown to bind to the adapter insulin receptor substrate 4 (IRS4) to mediate translocation of ... 2004). "IRAS, the human homologue of Nischarin, prolongs survival of transfected PC12 cells". Cell Death Differ. 10 (8): 933-5 ...
Human Hsc70 has 85% identity with human Hsp70 (SDSC workbench, blosom26 default analysis). The scientific community has long ... In later stages of apoptosis the entire cell becomes fragmented, forming a number of plasma membrane-bounded apoptotic bodies ... Sarkar S, Pollack BP, Lin KT, Kotenko SV, Cook JR, Lewis A, Pestka S (Dec 2001). "hTid-1, a human DnaJ protein, modulates the ... Ajuh P, Kuster B, Panov K, Zomerdijk JC, Mann M, Lamond AI (Dec 2000). "Functional analysis of the human CDC5L complex and ...
Apoptotic mechanisms in the CNS are still not well understood, yet it is thought that apoptosis of interneurons is a self- ... In humans, PCD in progenitor cells starts at gestational week 7 and remains until the first trimester. This process of cell ... The BCR-ABL oncogene has been found to be involved in the development of cancer in humans. c-Myc is involved in the regulation ... Several pro-apoptotic signals, such as TNF, TRAIL, and FADD, also induce autophagy. Additionally, Bcl-2 inhibits Beclin-1- ...
2006). "Clearance of apoptotic cells in human SLE". Curr. Dir. Autoimmun. Current Directions in Autoimmunity. 9: 173-87. doi: ... SLE is associated with defects in apoptotic clearance, and the damaging effects caused by apoptotic debris. Early apoptotic ... Apoptotic cells also express "find-me" signals, to attract macrophages and dendritic cells. When apoptotic material is not ... accumulation of apoptotic debris can be observed in GC because of an ineffective clearance of apoptotic cells. In close ...
Human Nature. 11(1): 27-42. Seymour, F.I.; Duffy, C.; Koerner, A. (1935). "A case of authenticated fertility in a man of 94". ... A Hormonally Controlled Apoptotic Process". Endocrine Reviews. 15 (6): 707-725. doi:10.1210/er.15.6.707. Hudson, M. (2005). Why ... The Patriarch hypothesis is an hypothes to explain the occurrence of menopause in human females and how a long post-fertile ... However, INK4a/ARF situated on the human chromosome 9p21 does appear to act as a tumour suppressor therefore extending ...
Apoptotic chromatin condensation inducer in the nucleus is a protein that in humans is encoded by the ACIN1 gene. GRCh38: ... "Entrez Gene: ACIN1 apoptotic chromatin condensation inducer 1". Human ACIN1 genome location and ACIN1 gene details page in the ... 2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci ... Kim JE, Tannenbaum SR, White FM (2005). "Global phosphoproteome of HT-29 human colon adenocarcinoma cells". J. Proteome Res. 4 ...
Apoptotic protease activating factor 1, also known as APAF1, is a human homolog of C. elegans CED-4 gene. This gene encodes a ... Kim H, Jung YK, Kwon YK, Park SH (1999). "Assignment of apoptotic protease activating factor-1 gene (APAF1) to human chromosome ... APAF1 apoptotic peptidase activating factor 1". Zou H, Henzel WJ, Liu X, Lutschg A, Wang X (Aug 1997). "Apaf-1, a human protein ... Human APAF1 genome location and APAF1 gene details page in the UCSC Genome Browser. Smith TF, Gaitatzes C, Saxena K, Neer EJ ( ...
"Human PubMed Reference:". "Mouse PubMed Reference:". Arnemann J, Spurr NK, Buxton RS (Jul 1992). "The human gene (DSG3) coding ... 2001). "The fate of desmosomal proteins in apoptotic cells". J. Biol. Chem. 276 (44): 41175-81. doi:10.1074/jbc.M105769200. ... 1994). "The human genes for desmogleins (DSG1 and DSG3) are located in a small region on chromosome 18q12". Genomics. 20 (3): ... Desmoglein-3 is a protein that in humans is encoded by the DSG3 gene. Desmosomes are cell-cell junctions between epithelial, ...
... is its human gene and is pro-apoptotic. The protein encoded by this gene is a bZIP transcription factor which can bind as ... CEBPE protein, human at the US National Library of Medicine Medical Subject Headings (MeSH) Human CEBPE genome location and ... Chumakov AM, Grillier I, Chumakova E, Chih D, Slater J, Koeffler HP (Mar 1997). "Cloning of the novel human myeloid-cell- ... Antonson P, Stellan B, Yamanaka R, Xanthopoulos KG (Jul 1996). "A novel human CCAAT/enhancer binding protein gene, C/EBPepsilon ...
We are far, but if we come to better understand the steps of this phenomenon in the Human, a coroner could via a "postmortem ... Javan, G. T., Can, I., Finley, S. J., & Soni, S. (2015). The apoptotic thanatotranscriptome associated with the liver of ... Whether there is the same in humans, because previous studies have already shown that in people dead by trauma, heart attack or ... Some authors in 2015 introduced the concept of "thanatotranscriptome apoptotic" Test another hypothesis is that after death, a ...
Their apoptotic cells are similar to homologous to mammalian. However, maintenance of long-lived cells involves proteins such ... as SDLAGL that are highly similar to yeast and human homologs. Certain inorganic materials, such as iron and selenium, ... Researchers have discovered that apoptotic factors are induced in the tissue that is rejected. Suberites consist of many ... Suberites can be susceptible to infection which often stimulates cell death through apoptotic pathways. Suberites, namely S. ...
... human gene location in the UCSC Genome Browser. SAP18 human gene details in the UCSC Genome Browser.. ... Additionally, SAP18s splice variants are implicated in apoptotic cycles. SAP18 has been shown to interact with POLE2, and RGS10 ... Histone deacetylase complex subunit SAP18 is an enzyme that in humans is encoded by the SAP18 gene. Histone acetylation plays a ... "Human PubMed Reference:". "Mouse PubMed Reference:". Zhang Y, Iratni R, Erdjument-Bromage H, Tempst P, Reinberg D (May 1997). " ...
Anoikis Apaf-1 Apo2.7 Apoptotic DNA fragmentation Atromentin induces apoptosis in human leukemia U937 cells. Autolysis ... Before the apoptotic cell is disposed of, there is a process of disassembly. There are three recognized steps in apoptotic cell ... Caspase-independent apoptotic pathway There also exists a caspase-independent apoptotic pathway that is mediated by AIF ( ... Liu, Y; McKalip, A; Herman, B (2000). "Human Papillomavirus Type 16 E6 and HPV-16 E6/E7 Sensitize Human Keratinocytes to ...
Eyes absent homolog 2 is a protein that in humans is encoded by the EYA2 gene. This gene encodes a member of the eyes absent ( ... Clark SW, Fee BE, Cleveland JL (Feb 2002). "Misexpression of the eyes absent family triggers the apoptotic program". The ... Fee BE, Doyle CA, Cleveland JL (Feb 2002). "A novel Eyes Absent 2 protein is expressed in the human eye". Gene. 285 (1-2): 221- ... Human Molecular Genetics. 8 (1): 11-23. doi:10.1093/hmg/8.1.11. PMID 9887327. Fan X, Brass LF, Poncz M, Spitz F, Maire P, ...
Apoptosis regulator BAX, also known as bcl-2-like protein 4, is a protein that in humans is encoded by the BAX gene. BAX is a ... The BAX gene was the first identified pro-apoptotic member of the Bcl-2 protein family. Bcl-2 family members share one or more ... Komatsu K, Miyashita T, Hang H, Hopkins KM, Zheng W, Cuddeback S, Yamada M, Lieberman HB, Wang HG (2000). "Human homologue of S ... BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety ...
"The human thymus microenvironment: in vivo identification of thymic nurse cells and other antigenically-distinct subpopulations ... Thus, since not all thymocytes internalized by TNCs went through apoptotic pathways, this was used to conclude that thymic ... "The human thymus microenvironment: in vivo identification of thymic nurse cells and other antigenically-distinct subpopulations ... "Lysosomal-mediated degradation of apoptotic thymocytes within thymic nurse cells." Cellular immunology 197.2 (1999): 108-115. ...
Phospholipid scramblase 3 is an enzyme that in humans is encoded by the PLSCR3 gene (abbreviated to PLS3 in this section). Like ... This is very important because mitochondria are central in the apoptotic cell pathway. This newly found member of the ... and apoptotic response". Molecular Cancer Research. 1 (12): 892-902. PMID 14573790. Liu J, Chen J, Dai Q, Lee RM (Mar 2003). " ... "Human PubMed Reference:". "Mouse PubMed Reference:". Wiedmer T, Zhou Q, Kwoh DY, Sims PJ (Jul 2000). "Identification of three ...
DnaJ homolog subfamily C member 3 is a protein that in humans is encoded by the DNAJC3 gene. The protein encoded by this gene ... In later stages of apoptosis the entire cell becomes fragmented, forming a number of plasma membrane-bounded apoptotic bodies ... Ladiges W, Morton J, Hopkins H, Wilson R, Filley G, Ware C, Gale M (Mar 2002). "Expression of human PKR protein kinase in ... Korth MJ, Edelhoff S, Disteche CM, Katze MG (Jan 1996). "Chromosomal assignment of the gene encoding the human 58-kDa inhibitor ...
... and functional analysis of a novel human cDNA (BNIP3L) encoding a protein homologous to human NIP3". Genes Chromosomes Cancer. ... also an apoptotic protector. The protein encoded by this gene is a functional homolog of BNIP3, a proapoptotic protein. This ... "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome ... Human BNIP3L genome location and BNIP3L gene details page in the UCSC Genome Browser. Chen G, Cizeau J, Vande Velde C, Park JH ...
Neural development Axon guidance Pioneer neuron Pioneer axon Neural development in humans Human brain development timeline ... The netrin receptors DCC and UNC5H are responsible for apoptotic regulation. The absence of netrin 1 is responsible for ... In various human cancers, it has been shown that netrin becomes over-expressed. In conjunction, it has been shown that certain ... This has been observed in the human colon epithelium, where higher levels of natural cell death at the upper portion of the ...
Human BNIP3 genome location and BNIP3 gene details page in the UCSC Genome Browser. As of this edit, this article uses content ... BNIP3 is a member of the apoptotic Bcl-2 protein family that is involved an atypical programmed cell death pathway resembling ... BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 is a protein that in humans is encoded by the BNIP3 gene. ... This gene contains a BH3 domain and a transmembrane domain, which have been associated with pro-apoptotic function. The dimeric ...
Campanella ME, Chu H, Low PS (February 2005). "Assembly and regulation of a glycolytic enzyme complex on the human erythrocyte ... In addition, nuclear translocation of GAPDH has been reported in Parkinson's disease (PD), and several anti-apoptotic PD drugs ... GAPDH is overexpressed in multiple human cancers, such as cutaneous melanoma, and its expression is positively correlated with ... strongly reduces the apoptotic action of GAPDH by preventing its S-nitrosylation and might thus be used as a drug. GAPDH acts ...
regulation of apoptotic process. · cellular protein metabolic process. · ventricular cardiac muscle cell development. · ... Human laminopathies: nuclei gone genetically awry. Nat. Rev. Genet. December 2006, 7 (12): 940-52. PMID 17139325. doi:10.1038/ ... apoptotic process. · cellular component disassembly involved in execution phase of apoptosis. · activation of signaling protein ... Life at the edge: the nuclear envelope and human disease. Nat. Rev. Mol. Cell Biol. 2002, 3 (8): 575-85. PMID 12154369. doi: ...
Shahneh FZ, Baradaran B, Orangi M, Zamani F. In vitro cytotoxic and apoptotic activity of four Persian medicine plants on human ... Apoptotic effects of non-edible parts of Punica granatum on human multiple myeloma cells. ... These results documented the cytotoxic and apoptotic effects of P. granatum extracts on human U266 multiple myeloma cells via ... Anticancer therapy targeting the apoptotic pathway. Lancet Oncol. 2003;4:721-9.CrossRefPubMedGoogle Scholar ...
In the current study, human monoclonal antibodies with binding specificity for apoptotic cells were isolated from the bone ... This may suggest a potentially great heterogeneity in human antibodies recognizing PC-related epitopes on apoptotic cells. To ... Interestingly, three of the four identified apoptotic cell-specific antibody clones were encoded by VH3 region rearrangements ... Our findings may have implication for improved prognostic testing and therapeutic interventions in human inflammatory disease. ...
miR-526a regulates apoptotic cell growth in human carcinoma cells.. [Xiaoli Yang, Cui Wang, Changzhi Xu, Zhifeng Yan, Congwen ...
... there is a paucity of data derived from the study of human heart tissue. In this study, we used DNA microarray profiling to ... investigate changes in the expression of genes involved in apoptosis that occur in human idiopathic dilated cardiomyopathic ... Alterations in apoptotic signaling in human idiopathic cardiomyopathic hearts in failure. American Journal of Physiology. Heart ... This study identifies several pathways that are altered in human heart failure and provides new targets for therapy ...
Wright stain of human macrophages after exposure to either murine apoptotic thymocytes (C and D) or autologous human apoptotic ... A) Apoptotic murine thymocytes were offered to human macrophages in the presence of 15% normal non- heat-inactivated human ... 1994) Activation of the alternative pathway of human complement by apoptotic human umbilical vein endothelial cells. J Biochem ... 1998) Human CD14 mediates recognition and phagocytosis of apoptotic cells. Nature 392:505-509, pmid:9548256.. ...
HIV-1 Infection of Human MDMs Does Not Activate Apoptotic Effector Caspases or Lead to Cell Death.. To understand the dynamics ... Inhibition of the lncRNA SAF drives activation of apoptotic effector caspases in HIV-1-infected human macrophages. Saikat ... Inhibition of the lncRNA SAF drives activation of apoptotic effector caspases in HIV-1-infected human macrophages ... Inhibition of the lncRNA SAF drives activation of apoptotic effector caspases in HIV-1-infected human macrophages ...
Human cells consistently displayed significantly reduced apoptotic function relative to the chimpanzee and macaque cells. These ... In this study, we sought to further test the hypothesis that humans maintain a reduced apoptotic function relative to ... chimpanzees by conducting a series of apoptotic function assays on human, chimpanzee and macaque primary fibroblastic cells. ... results are consistent with earlier findings indicating that apoptotic function is reduced in humans relative to chimpanzees. ...
... *Authors: *Kamran Harati ... The first significant apoptotic response was observed after 6 h of incubation with 20.1±2.9% of the cells left apoptotic and ... apoptotic effects of pycnogenol on HT1080 human fibrosarcoma cells. International Journal of Oncology 46, no. 4 (2015): 1629- ... apoptotic effects of pycnogenol on HT1080 human fibrosarcoma cells. International Journal of Oncology 46.4 (2015): 1629-1636. ...
Exposure of human leukemic cell lines (HL-60, ML-1, U-937, MOLT-4, EOL-1) to short direct-current (d.c.) treatment induced ... Induction of apoptotic cell death by direct-current treatment in human leukemic cell lines. *Masatsugu Kurokawa. 1. , ... Kurokawa, M., Sakagami, H., Kokubu, F. et al. Induction of apoptotic cell death by direct-current treatment in human leukemic ... Exposure of human leukemic cell lines (HL-60, ML-1, U-937, MOLT-4, EOL-1) to short direct-current (d.c.) treatment induced ...
We report the first identified mutation in the gene encoding human cytochrome c (CYCS). Glycine 41, invariant throughout ... A mutation of human cytochrome c enhances the intrinsic apoptotic pathway but causes only thrombocytopenia Nat Genet. 2008 Apr; ... The mutation yields a cytochrome c variant with enhanced apoptotic activity in vitro. Notably, the family has no other ... We report the first identified mutation in the gene encoding human cytochrome c (CYCS). Glycine 41, invariant throughout ...
... a series of benzochromene derivatives were screened for their cytotoxic activity against seven human cancer cell lines by ... Cytotoxic and apoptotic effects of these compounds in human cancer cells indicated that they can be a good candidate for ... The effects of compounds on reactive oxygen species (ROS) and nitric oxide (NO) generations in three human breast cancer cell ... 17693016 - Differential apoptotic induction of gambogic acid, a novel anticancer natural product, .... ...
Dual involvement of caspase-4 in inflammatory and ER stress-induced apoptotic responses in human retinal pigment epithelial ... Dual involvement of Caspase-4 in Inflammatory and ER Stress-induced Apoptotic Responses in Human Retinal Pigment Epithelial ... Dual involvement of Caspase-4 in Inflammatory and ER Stress-induced Apoptotic Responses in Human Retinal Pigment Epithelial ... Dual involvement of Caspase-4 in Inflammatory and ER Stress-induced Apoptotic Responses in Human Retinal Pigment Epithelial ...
Bacterial cell death induced by human pro-apoptotic Bax is blocked by an RNase E mutant that functions in an anti-oxidant ... We have shown that a trace amount of human Bax induces the cell death of Escherichia coli, accompanied by damage to DNA, and ... The N-terminal region of the RNase E protein inhibits bacterial death induced by human Bax as well as paraquat through a unique ...
Antiproliferative and Apoptotic Effects of a Specific Antiprostate Stem Cell Single Chain Antibody on Human Prostate Cancer ... F. Nejatollahi, S. J. Hodgetts, P. J. Vallely, and J. P. Burnie, "Neutralising human recombinant antibodies to human ... Human prostate cancer cell lines, DU-145 and LNCaP, were purchased from National Cell Bank of Iran (NCBI, Pasteur Institute of ... The apoptotic effect 33.80% in DU145 cells treated with C5-II versus the apoptosis 2.74% in untreated cells indicated the ...
In the present study, we examined the effects of resveratrol on apoptotic biochemical events in Hep G2 cells induced by CTN. ... Active JNK was required for CTN-induced mitochondria-dependent apoptotic biochemical changes, including loss of MMP, and ... and these apoptotic biochemical events are blocked by pretreatment with resveratrol, which exerts antioxidant effects. ... results collectively demonstrate that CTN stimulates ROS generation and JNK activation for mitochondria-dependent apoptotic ...
Typical apoptotic characteristics, including chromatin condensation and fragmentation of nuclei, were observed and a high rate ... in the drug resistant human leukemia K562/A02 cells and further to explore potential mechanisms. After being incubated for 48 ... Apoptotic mechanism of human leukemia K562/A02 cells induced by magnetic iron oxide nanoparticles co-loaded with daunorubicin ... Apoptotic mechanism of human leukemia K562/A02 cells induced by magnetic iron oxide nanoparticles co-loaded with daunorubicin ...
Pro-apoptotic activity of α-bisabolol in preclinical models of primary human acute leukemia cells.. [Elisabetta Cavalieri, ... Our study provides the first evidence that α-bisabolol is a pro-apoptotic agent for primary human acute leukemia cells. ... We previously demonstrated that the plant-derived agent α-bisabolol enters cells via lipid rafts, binds to the pro-apoptotic ... α-bisabolol acted as a pro-apoptotic agent via a direct damage to mitochondrial integrity, which was responsible for the ...
The Acetone Extract of Sclerocarya birrea (Anacardiaceae) Possesses Antiproliferative and Apoptotic Potential against Human ... as well as formation of apoptotic bodies. The acetone extract of S. birrea possesses antiproliferative and apoptotic potential ... Morphological examination also displayed apoptotic characteristics in the treated cells, including clumping, condensation, and ... The extract also exerted apoptotic programmed cell death in MCF-7 cells with significant effect on the DNA. ...
... we investigated the potential cytotoxicity and apoptotic effects of MA in human keratinocyte cell lines (HaCaT). The data ... To investigate the biological effects of MA in human skin keratinocytes, ... and sub-G1 phase in HaCaT cells and normal human epidermal keratinocytes (NHEKs). Flow cytometric assays also showed that MA ... Hsiao Y-P, Lai W-W, Wu S-B, Tsai C-H, Tang S-C, Chung J-G, Yang J-H. Triggering Apoptotic Death of Human Epidermal ...
... Sloniecka, Marta Umeå University. ... Inhibition of the PKB/Aktpathway revealed that its activation is essential for mediating the anti-apoptotic effect of ACh in ... In the studies of this thesis, it is hypothesized that neuropeptides and neurotransmitters areproduced by human keratocytes and ... Cultured primary cells of the human corneal stroma expressed keratocyte markers (keratocan,lumican, CD34, and ALDH), the ...
These liposomes contained phosphatidylserine (PS) -the main signal of the apoptotic cell membrane- and β-cell autoantigens. To ... These liposomes contained phosphatidylserine (PS) -the main signal of the apoptotic cell membrane- and β-cell autoantigens. To ... PS accelerated phagocytosis of liposomes with a dynamic typical of apoptotic cell clearance, preserving DCs viability. After PS ... PS accelerated phagocytosis of liposomes with a dynamic typical of apoptotic cell clearance, preserving DCs viability. After PS ...
Transforming Growth Factor β1 Induces Apoptotic Cell Death in Cultured Human Gastric Carcinoma Cells. Kazuyoshi Yanagihara and ... Transforming Growth Factor β1 Induces Apoptotic Cell Death in Cultured Human Gastric Carcinoma Cells ... Transforming Growth Factor β1 Induces Apoptotic Cell Death in Cultured Human Gastric Carcinoma Cells ... Transforming Growth Factor β1 Induces Apoptotic Cell Death in Cultured Human Gastric Carcinoma Cells ...
Selection of Human Cervical Epithelial Cells That Possess Reduced Apoptotic Potential to Low-Oxygen Conditions. Charlotte Y. ... Selection of Human Cervical Epithelial Cells That Possess Reduced Apoptotic Potential to Low-Oxygen Conditions ... Selection of Human Cervical Epithelial Cells That Possess Reduced Apoptotic Potential to Low-Oxygen Conditions ... Selection of Human Cervical Epithelial Cells That Possess Reduced Apoptotic Potential to Low-Oxygen Conditions ...
Induction of apoptosis in human NT2/D1 cells assessed as late apoptotic cells at 25 uM after 4 hrs by annexin V/propidium ...
Tumor necrosis factor-α (TNF-α) has been suggested to exert detrimental effects on hematopoietic progenitor function that might limit the success of transplants. In this study, we assessed the influences of TNF-α and its two cognate receptors on the function of fresh umbilical cord blood (UCB) and c …
  • By studying now benign human tumor cells derived from the linings of the brain and spinal cord, so called meningiomas, Hattermann et al. (biomedcentral.com)
  • In humans, autoantibodies originally elicited against recoverin expressed in tumor cells may damage retinal photoreceptors and play a role in the pathogenesis of cancer-associated retinopathy. (mendeley.com)
  • Previous studies have shown that BITC produces a large number of intracellular reactive oxygen species (ROS) and increases intracellular Ca 2+ release from endoplasmic reticulum (ER), leading to the activation of the apoptotic mechanism in tumor cells. (edp-open.org)
  • 1 μmol/L). Growth suppression of INA-6 correlated with an increase in the percentage of apoptotic cells and inhibition of signal transducer and activator of transcription 3 phosphorylation. (aacrjournals.org)
  • These data suggest that targeting this CD44-mediated inhibition by apoptotic microparticles could be a novel strategy to potentiate DC activation of HIV-specific immunity. (ox.ac.uk)
  • Activation of Akt by retroviral transduction of primary cultures of human keratinocytes resulted in an increase in abortive clones founded by transit amplifying cells, while inhibition of the upstream kinase, PI3 kinase, inhibited suspension-induced terminal differentiation. (pubmedcentralcanada.ca)
  • Arenobufagin, a natural bufadienolide from toad venom, induces apoptosis and autophagy in human hepatocellular carcinoma cells through inhibition of PI3K/Akt/mTOR pathway. (qxmd.com)
  • CONCLUSION: LL-37 strongly attenuates lipopolysaccharide-induced cytokine and chemokine expression and, in high concentrations, reduces cell proliferation through inhibition of DNA synthesis and by promoting apoptosis in human periodontal ligament cells. (mau.se)
  • ApoBDs are the largest type of extracellular vesicle (typically 1-5 μm in diameter) generated through a process termed apoptotic cell disassembly 1 . (nature.com)
  • Stellate cells, but not hepatocytes, readily engulfed apoptotic bodies in a time-dependent manner as assessed by confocal microscopy. (elsevier.com)
  • Our findings indicate that hESCs express elevated levels of the pro-apoptotic BH3-only BCL-2 family members NOXA, BIK, BIM, BMF and PUMA when compared with differentiated cells and cancer cells. (ca.gov)
  • Recombinant antibodies have recently shown great promise in the replacement of monoclonal antibodies in different medical areas such as immunotherapy against human malignancies [ 16 - 19 ]. (hindawi.com)
  • Advantages of scFvs over the intact antibodies including smaller size, fast penetration and tight binding to target tissue, fast clearance from the body, and better pharmacokinetic properties as well as fully human origin have offered scFvs as desirable tools for both the imaging and therapeutic purposes [ 21 - 24 ]. (hindawi.com)
  • Using conventional hybridoma technology, not only are fully human monoclonal IgM antibodies isolated, but also new tumor-related targets can be identified using the same experimental approach. (iospress.com)
  • METHODS: Human, rat, and rabbit antirecoverin antibodies were purified using a recoverin-affinity column. (mendeley.com)
  • The effect of generated polyclonal antibodies on viability and apoptosis of human epidermoid carcinoma derived A431 cell line was assessed using MTT and Annexin V-propidium iodide assays. (exp-oncology.com.ua)
  • It has been shown that immune serum with polyclonal antibodies against HB-EGF was able to block the mitogenic activation of the cells with HB-EGF and cause apoptotic cell death. (exp-oncology.com.ua)
  • The extract also exerted apoptotic programmed cell death in MCF-7 cells with significant effect on the DNA. (hindawi.com)
  • The cytotoxic activity of the Myristica fragrans Houtt mace acetone extract was assayed by MTT assay on human oral epidermal carcinoma KB cell lines. (scielo.br)
  • The apoptotic potential of mace extract was accompanied by reduced gene expression of Bcl-2 compared to the untreated KB cells. (scielo.br)
  • Conclusively, the aqueous extract of Ganoderma lucidum proves to be suitable for the development of an antitumour agent as shown by its apoptotic effect reported in this study. (scialert.net)
  • In addition, concomitant treatment of the MCF-7 cells with SKE and vincristine produced a potent anti-proliferative and pro-apoptotic effect compared to extract or drug alone. (ac.ir)
  • In conclusion, satureja extract has a potential anti-cancer property against human breast cancer cells and its combination with chemotherapeutic agent vincristine may induce cell death effectively and be a potent modality to treat this type of cancer. (ac.ir)
  • The anti oxidant activity of an aqueous extract of Urtica dioica leaf was measured by MTT assay and the FRAP method while its anti-proliferative activity on the human breast cancer cell line (MCF-7) and fibroblasts isolated from foreskin tissue was evaluated using MTT assay. (koreascience.or.kr)
  • Cytotoxic and Apoptotic Potential of Rheum turkestanicum Janisch Root Extract on Human Cancer and Normal Cells', Iranian Journal of Pharmaceutical Research , 12(4), pp. 811-819. (ac.ir)
  • Although cell and animal models suggest a role for altered gene expression in the transition to heart failure, there is a paucity of data derived from the study of human heart tissue. (rti.org)
  • Here we examined the effect of TGF-β 1 on the growth of these lines as compared to five other human gastric adenocarcinoma cell lines. (aacrjournals.org)
  • In this report, we examined this adverse effect of cigarette smoke on human gingival fibroblasts (HGFs) which are critical not only in maintaining gingival tissue architecture but also in mediating immune responses. (medsci.org)
  • We examined the effect of black raspberry (BR) phenolics on cell proliferation of two phenotypically diverse human cancer cell lines isolated from patients with different stages and grades of transitional cell carcinoma. (osu.edu)
  • Subsequently, the anticancer effect of such IgYs was determined by MTT assay in the MCF7 human breast cancer cell line. (waocp.org)
  • Flow cytometric analysis (FACS) of human cultured astrocytes shortly incubated with HIV-1-infected M/M supernatants showed apoptotic cell death, an effect accompanied by pronounced staining for nitrotyrosine (footprint of peroxynitrite) and by abnormal formation of malondialdehyde (MDA). (biomedcentral.com)
  • The present experiments have been performed in order to evaluate the role of peroxynitrite in the apoptotic cell death of astroglial cells incubated with supernatants of HIV-1-infected M/M and ascertain the protective effect of FeTMPS, a novel peroxynitrite decomposition catalyst on HIV-1-related apoptosis of astroglial cells. (biomedcentral.com)
  • In this work, we examine the effect of melatonin on RAMOS-1 human leukaemic cells. (univpm.it)
  • These results suggested that Xrel3, a homolog of c-Rel, causes an anti-apoptotic effect (chemoresistance) when cells are initially exposed to low cisplatin concentrations (1 μM). (mun.ca)
  • However, with prolonged contact to 1 μM cisplatin or upon 24 hours exposure to 5 μM cisplatin, Xrel3 had a synergistic apoptotic effect when coupled with cisplatin, thus promoting chemosensitivity and cell death. (mun.ca)
  • In this study, the effect of melatonin on hyperthermia-induced apoptosis was explored using human leukemia cells. (uthscsa.edu)
  • The potentiation of cell death was achieved with 1 mmol/L concentrations of the indoleamine but not with concentrations close to physiological levels in blood (1 nmol/L). This effect was associated to an enhancement of the apoptotic response, revealed by an increase in cells with hypodiploid DNA content and activation of multiple caspases (caspase-2, caspase-3, caspase-8, and caspase-9). (uthscsa.edu)
  • The purpose of this study was to examine the anticancer effect and molecular mechanism of BITC on human cisplatin-resistant oral cancer CAR cells. (edp-open.org)