A localized infection of mucous membranes or skin caused by toxigenic strains of CORYNEBACTERIUM DIPHTHERIAE. It is characterized by the presence of a pseudomembrane at the site of infection. DIPHTHERIA TOXIN, produced by C. diphtheriae, can cause myocarditis, polyneuritis, and other systemic toxic effects.
A disease caused by tetanospasmin, a powerful protein toxin produced by CLOSTRIDIUM TETANI. Tetanus usually occurs after an acute injury, such as a puncture wound or laceration. Generalized tetanus, the most common form, is characterized by tetanic muscular contractions and hyperreflexia. Localized tetanus presents itself as a mild condition with manifestations restricted to muscles near the wound. It may progress to the generalized form.
A disease caused by potent protein NEUROTOXINS produced by CLOSTRIDIUM BOTULINUM which interfere with the presynaptic release of ACETYLCHOLINE at the NEUROMUSCULAR JUNCTION. Clinical features include abdominal pain, vomiting, acute PARALYSIS (including respiratory paralysis), blurred vision, and DIPLOPIA. Botulism may be classified into several subtypes (e.g., food-borne, infant, wound, and others). (From Adams et al., Principles of Neurology, 6th ed, p1208)
The formaldehyde-inactivated toxin of Corynebacterium diphtheriae. It is generally used in mixtures with TETANUS TOXOID and PERTUSSIS VACCINE; (DTP); or with tetanus toxoid alone (DT for pediatric use and Td, which contains 5- to 10-fold less diphtheria toxoid, for other use). Diphtheria toxoid is used for the prevention of diphtheria; DIPHTHERIA ANTITOXIN is for treatment.
A species of gram-positive, asporogenous bacteria in which three cultural types are recognized. These types (gravis, intermedius, and mitis) were originally given in accordance with the clinical severity of the cases from which the different strains were most frequently isolated. This species is the causative agent of DIPHTHERIA.
An ENTEROTOXIN from VIBRIO CHOLERAE. It consists of two major protomers, the heavy (H) or A subunit and the B protomer which consists of 5 light (L) or B subunits. The catalytic A subunit is proteolytically cleaved into fragments A1 and A2. The A1 fragment is a MONO(ADP-RIBOSE) TRANSFERASE. The B protomer binds cholera toxin to intestinal epithelial cells, and facilitates the uptake of the A1 fragment. The A1 catalyzed transfer of ADP-RIBOSE to the alpha subunits of heterotrimeric G PROTEINS activates the production of CYCLIC AMP. Increased levels of cyclic AMP are thought to modulate release of fluid and electrolytes from intestinal crypt cells.
A species of anaerobic, gram-positive, rod-shaped bacteria in the family Clostridiaceae that produces proteins with characteristic neurotoxicity. It is the etiologic agent of BOTULISM in humans, wild fowl, HORSES; and CATTLE. Seven subtypes (sometimes called antigenic types, or strains) exist, each producing a different botulinum toxin (BOTULINUM TOXINS). The organism and its spores are widely distributed in nature.
Toxic proteins produced from the species CLOSTRIDIUM BOTULINUM. The toxins are synthesized as a single peptide chain which is processed into a mature protein consisting of a heavy chain and light chain joined via a disulfide bond. The botulinum toxin light chain is a zinc-dependent protease which is released from the heavy chain upon ENDOCYTOSIS into PRESYNAPTIC NERVE ENDINGS. Once inside the cell the botulinum toxin light chain cleaves specific SNARE proteins which are essential for secretion of ACETYLCHOLINE by SYNAPTIC VESICLES. This inhibition of acetylcholine release results in muscular PARALYSIS.
An ADP-ribosylating polypeptide produced by CORYNEBACTERIUM DIPHTHERIAE that causes the signs and symptoms of DIPHTHERIA. It can be broken into two unequal domains: the smaller, catalytic A domain is the lethal moiety and contains MONO(ADP-RIBOSE) TRANSFERASES which transfers ADP RIBOSE to PEPTIDE ELONGATION FACTOR 2 thereby inhibiting protein synthesis; and the larger B domain that is needed for entry into cells.
A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc.
The measurement of infection-blocking titer of ANTISERA by testing a series of dilutions for a given virus-antiserum interaction end-point, which is generally the dilution at which tissue cultures inoculated with the serum-virus mixtures demonstrate cytopathology (CPE) or the dilution at which 50% of test animals injected with serum-virus mixtures show infectivity (ID50) or die (LD50).
A method of measuring the effects of a biologically active substance using an intermediate in vivo or in vitro tissue or cell model under controlled conditions. It includes virulence studies in animal fetuses in utero, mouse convulsion bioassay of insulin, quantitation of tumor-initiator systems in mouse skin, calculation of potentiating effects of a hormonal factor in an isolated strip of contracting stomach muscle, etc.
Gene Expression Regulation, Bacterial
Deliberate stimulation of the host's immune response. ACTIVE IMMUNIZATION involves administration of ANTIGENS or IMMUNOLOGIC ADJUVANTS. PASSIVE IMMUNIZATION involves administration of IMMUNE SERA or LYMPHOCYTES or their extracts (e.g., transfer factor, immune RNA) or transplantation of immunocompetent cell producing tissue (thymus or bone marrow).
Protein synthesized by CLOSTRIDIUM TETANI as a single chain of ~150 kDa with 35% sequence identity to BOTULINUM TOXIN that is cleaved to a light and a heavy chain that are linked by a single disulfide bond. Tetanolysin is the hemolytic and tetanospasmin is the neurotoxic principle. The toxin causes disruption of the inhibitory mechanisms of the CNS, thus permitting uncontrolled nervous activity, leading to fatal CONVULSIONS.
A severe condition resulting from bacteria invading healthy muscle from adjacent traumatized muscle or soft tissue. The infection originates in a wound contaminated with bacteria of the genus CLOSTRIDIUM. C. perfringens accounts for the majority of cases (over eighty percent), while C. noyvi, C. septicum, and C. histolyticum cause most of the other cases.
An acute infection caused by the spore-forming bacteria BACILLUS ANTHRACIS. It commonly affects hoofed animals such as sheep and goats. Infection in humans often involves the skin (cutaneous anthrax), the lungs (inhalation anthrax), or the gastrointestinal tract. Anthrax is not contagious and can be treated with antibiotics.
Infant, Newborn, Diseases
Diseases of newborn infants present at birth (congenital) or developing within the first month of birth. It does not include hereditary diseases not manifesting at birth or within the first 30 days of life nor does it include inborn errors of metabolism. Both HEREDITARY DISEASES and METABOLISM, INBORN ERRORS are available as general concepts.
A suspension of killed Bordetella pertussis organisms, used for immunization against pertussis (WHOOPING COUGH). It is generally used in a mixture with diphtheria and tetanus toxoids (DTP). There is an acellular pertussis vaccine prepared from the purified antigenic components of Bordetella pertussis, which causes fewer adverse reactions than whole-cell vaccine and, like the whole-cell vaccine, is generally used in a mixture with diphtheria and tetanus toxoids. (From Dorland, 28th ed)
These observations are in accordance with those made of Type I toxin-antitoxin systems. In type I toxin-antitoxin systems, the ... Type I toxin-antitoxin loci are frequently found in both prokaryotic chromosomes and plasmids. The secondary structure of ... Hok/sok system Toxin-antitoxin system Findeiss S, Schmidtke C, Stadler PF, Bonas U (March 2010). "A novel family of plasmid- ... Gerdes K, Wagner EG (April 2007). "RNA antitoxins". Curr. Opin. Microbiol. 10 (2): 117-124. doi:10.1016/j.mib.2007.03.003. PMID ...
Antitoxins. Substances in the serum that can neutralize. the activity of toxins, enabling passive immunization. von Behring and ... went on to develop the diphtheria antitoxin, which became the first major success of modern immunotherapy. The presence and ... were used to vaccinate animals in an attempt to demonstrate that immunized serum contained an antitoxin that could neutralize ...
Louis children died from contaminated diphtheria antitoxin. The horse from which the antitoxin was derived died of tetanus. ... Behring used this antitoxin (now known to consist of antibodies that neutralize the toxin produced by C. diphtheriae) for human ... They also immunized goats and horses in the same way and showed that an "antitoxin" made from serum of immunized animals could ... Protection can be verified by measuring the antitoxin level in the blood. Diphtheria can be prevented in those exposed as well ...
The Adventure Girls
27 (Associated Press).-Nome has a diphtheria epidemic and no antitoxin. The nearest known supply of antitoxin is at Anchorage, ... "DOGS RUSH ANTI-TOXIN FOR NOME EPIDEMIC; Two Fliers Volunteer Services". The New York Times. Associated Press. January 29, 1925 ... The antitoxin units are to leave Seattle Saturday on the steamship Alameda. . . . WASHINGTON, Jan. 29.-Possibility that an ... This is reminiscent of the 1925 serum run to Nome, a sled dog relay carrying antitoxin that was responsible for halting a ...
... -antitoxin system. References. *^ "toxin" at Dorland's Medical Dictionary *^ "toxin - Definition from the Merriam- ...
United States biological defense program
The products included diagnostic reagents and procedures, drugs, vaccines, toxoids, and antitoxins. Emphasis is placed on ... Antitoxins for diseases such as botulism; Human immune globulin preparations (passive antibody protection) against various ...
VapC is strongly inhibited by direct protein interaction with VapB, its cognate antitoxin. The toxin-antitoxin complex is ... Zhang, YX; Li, J; Guo, XK; Wu, C; Bi, B; Ren, SX; Wu, CF; Zhao, GP (Jun 2004). "Characterization of a novel toxin-antitoxin ... The toxins in this family are thought to perform RNA cleavage, which is inhibited by the co-expression of the antitoxin, in a ... Toxin-antitoxin database Robson, Jennifer; McKenzie, Joanna L.; Cursons, Ray; Cook, Gregory M.; Arcus, Vickery L. (17 July 2009 ...
List of German inventors and discoverers
Discovered the diphtheria antitoxin. It was the world's first cure for a disease (1891). He was awarded history's first Nobel ... Emil von Behring: Discovery of diphtheria antitoxin Fabian Gottlieb von Bellingshausen: Navigator and explorer. Discovered the ...
Lee, Elmer (August 1896). "Diphtheria and its antitoxin". The Laryngoscope. 1 (2): 105-106. doi:10.1288/00005537-189608000- ...
Francis de Havilland Hall
Hall, F. D. (1894). "Antitoxin Treatment of Diphtheria". British Medical Journal. 2 (1757): 513. doi:10.1136/bmj.2.1757.513. ...
St. Mary's General Hospital (Passaic, New Jersey)
"Tetanus Antitoxin Successfully Administered". Reading Times. 1898-10-20. p. 2. Retrieved 2017-10-27. "General Hospital May ...
Timeline of human vaccines
"Antitoxin and Serum Therapy". The History of Vaccines. Philadelphia: The College of Physicians of Philadelphia. 2020. Retrieved ... serum antitoxin) by Emil von Behring 1896 - First vaccine for typhoid fever by Almroth Edward Wright, Richard Pfeiffer, and ...
Rees, Anthony R. (2015). The Antibody Molecule: From Antitoxins to Therapeutic Antibodies. Oxford University Press. pp. 104-120 ...
The second antitoxin, heptavalent (A,B,C,D,E,F,G) botulinum antitoxin, is derived from "despeciated" equine IgG antibodies ... This human-derived antitoxin has been shown to be both safe and effective for the treatment of infant botulism. However, the ... To avoid this, a human-derived antitoxin has been developed and approved by the U.S. FDA in 2003 for the treatment of infant ... 2018). "Efficacy of Antitoxin Therapy in Treating Patients With Foodborne Botulism: A Systematic Review and Meta-analysis of ...
Toxin-antitoxin system PDB: 1BRS; Buckle AM, Schreiber G, Fersht AR (August 1994). "Protein-protein recognition: crystal ...
He also worked on antitoxins for diphtheria and anthrax. Kitasato and Behring demonstrated the value of antitoxin in preventing ... Sri Kantha, S. A Centennial review; the 1890 Tetanus antitoxin paper of von Behring and Kitasato and the related developments. ... Kitasato and Emil von Behring, working together in Berlin in 1890, announced the discovery of diphtheria antitoxin serum. Von ...
An antitoxin for scarlet fever was developed in 1924. The first toxin which causes this disease was cloned and sequenced in ... An antitoxin was produced before antibiotics; however, it was never made in sufficient quantities, and could not be used to ... These toxin-producing strains cause scarlet fever in people who do not already have antitoxin antibodies. Streptococcal ... and George Frederick Dick developed an antitoxin and vaccine for scarlet fever in 1924 which were later eclipsed by penicillin ...
The majority of PIN-domain proteins found in prokaryotes are the toxic components of toxin-antitoxin operons. These loci ... Gerdes K, Christensen SK, Løbner-Olesen A (May 2005). "Prokaryotic toxin-antitoxin stress response loci". Nature Reviews. ... "The PIN-domain ribonucleases and the prokaryotic VapBC toxin-antitoxin array". Protein Engineering, Design & Selection. 24 (1-2 ...
Gerdes K, Christensen SK and Lobner-Olesen A (2005). "Prokaryotic toxin-antitoxin stress response loci". Nat. Rev. Microbiol. ( ... Many stress-response toxins of prokaryotic toxin-antitoxin systems have been shown to have RNase activity and homology. EC 3.1. ... "Comprehensive functional analysis of Mycobacterium tuberculosis toxin-antitoxin systems: implications for pathogenesis, stress ...
... method of toxin neutralization by the antitoxin, and autoregulation of the addiction module by the antitoxin or toxin:antitoxin ... Once the antitoxin has bound to the toxin, the toxin prevents the proteases normally responsible for degrading antitoxin to do ... In addition, the transcription of the antitoxin RNA is heavily upregulated by a strong promoter which ensures excess antitoxin ... so that the antitoxin is available to immediately neutralize the toxin. This upstream placement of the antitoxin gene is found ...
Magnuson, Roy David (1 September 2007). "Hypothetical Functions of Toxin-Antitoxin Systems". Journal of Bacteriology. 189 (17 ...
ATC J06 - Immunszérumok és immunglobulinok - Wikipédia
J06AA01 Diphtheria antitoxin. J06AA02 Tetanus antitoxin. J06AA03 Snake venom antiserum. J06AA04 Botulinum antitoxin. J06AA05 ...
Corneal ulcers in animals
Tetanus antitoxin - can be delivered sub-conjunctivally. Contains macroglobulins with anti-collagenase effects. ...
In the last few years there are some new developments to create an antitoxin or a vaccine for the toxic snake bites. In 2005 a ... Rediocides A and G are found to be a possible antitoxin for α-cobratoxin. These rediocides bind at the same nicotinic ... Utsintong M, Kaewnoi A, Leelamanit W, Olson AJ, Vajragupta O (2009). "Rediocides A and G as potential antitoxins against cobra ...
Lister Institute of Preventive Medicine
The institute remained an important manufacturer of vaccines and antitoxins. It produced the 'triple vaccine' for diphtheria, ...
Biomedical Advanced Research and Development Authority
As part of a $450 million contract with BARDA for the SNS, Emergent also developed the only FDA-licensed botulinum antitoxin, ... BARDA also supported the development of the antitoxins Anthrasil of Cangene (March 2015 FDA approval) and Anthim of Elusys ... BARDA maintains a supply of botulism antitoxins through the Strategic National Stockpile (SNS). As of June, seven companies had ... "Health Canada approves Emergent BioSolutions' botulism antitoxin". Homeland Preparedness News. 2016-12-13. Retrieved 2017-01-19 ...
Harold Fowler McCormick
Sponsored Successful Search for Scarlet Fever Antitoxin. A Supporter of Opera". New York Times. October 17, 1941. Retrieved ...
Sponsored Successful Search for Scarlet Fever Antitoxin. A Supporter of Opera". New York Times. October 17, 1941. Retrieved ...
... immunoglobulin (TIG), also called tetanus antibodies or tetanus antitoxin. It can be given as intravenous ... In such cases, it can be given with or without tetanus immunoglobulin (also called tetanus antibodies or tetanus antitoxin ... In 1897, Edmond Nocard showed that tetanus antitoxin induced passive immunity in humans, and could be used for prophylaxis and ... Porter, J. D., Perkin, M. A., Corbel, M. J., Farrington, C. P., Watkins, J. T., Begg, N. T. (1992). "Lack of early antitoxin ...
Par stability determinant
The par locus contains two genes: fst which encodes a 33-amino acid toxic protein and a gene for RNAII, the small RNA anti- ... The par stability determinant is a 400 bp locus of the pAD1 plasmid which encodes a type I toxin-antitoxin system in ... Hayes F (September 2003). "Toxins-antitoxins: plasmid maintenance, programmed cell death, and cell cycle arrest". Science. 301 ... Page for fst antitoxin sRNA (RNAII) at Rfam. ...
Antitoxin - Wikipedia
An antitoxin is an antibody with the ability to neutralize a specific toxin. Antitoxins are produced by certain animals, plants ... To prevent serum sickness, it is often best to use an antitoxin obtained from the same species (e.g. use human antitoxin to ... 4 December 2018). "Medical definition of antitoxin". medterms.com. 2289. Antitoxins at the US National Library of Medicine ... When the antitoxin is obtained from the blood, it is purified and injected into a human or other animal, inducing temporary ...
Diphtheria antitoxin - Wikipedia
Diphtheria antitoxin was developed and came into medical use in the late 1800s. It is on the World Health Organizations List ... Diphtheria antitoxin (DAT) is a medication made up of antibodies used in the treatment of diphtheria. It is no longer ... Diphtheria antitoxin is made from the blood plasma of horses that have been immunized against diphtheria toxin. It works by ... Diphtheria Antitoxin at the US National Library of Medicine Medical Subject Headings (MeSH) Medicine portal. ...
Diphtheria Antitoxin (DAT) | CDC
Diphtheria Antitoxin (DAT). Use of DAT, requesting DAT, how to return unused DAT, DAT forms and worksheets ... If the clinician revises the patients diagnosis after the release of DAT and the diphtheria antitoxin is not given, then it ... The Food and Drug Administration has not licensed diphtheria antitoxin (DAT) for use in the United States. However, CDC is ...
Diphtheria Medication: Antitoxins, Macrolides, Antibiotic, Penicillin
Antitoxins. Class Summary. Diphtheria antitoxin was first used in the United States in 1891, derived from a horse serum, it ... Diphtheria antitoxin. Neutralizes toxin before it enters cells. Dose given depends on site of infection and length of time ... Diphtheria antitoxin can be obtained only from the CDC. For more information regarding acquisition, see the CDC website for ... The horse serum antitoxin is given to anyone suspected to have diphtheria and can be administered without confirmation from ...
An oxygen-sensitive toxin-antitoxin system. - PubMed - NCBI
An oxygen-sensitive toxin-antitoxin system.. Marimon O1, Teixeira JM1, Cordeiro TN1, Soo VW2, Wood TL2, Mayzel M3, Amata I1, ... The Hha and TomB proteins from Escherichia coli form an oxygen-dependent toxin-antitoxin (TA) system. Here we show that YmoB, ... the Yersinia orthologue of TomB, and its single cysteine variant [C117S]YmoB can replace TomB as antitoxins in E. coli. In ...
Tetanus antitoxin unit definition | Drugs.com
Funding for Anthrax Antitoxin Hits $149M
The antitoxin antibody is in development for biodefense applications. Three studies assessing the pharmacokinetics and safety ... "Advancing the development of both IV and IM administration of our antitoxin could provide two important options in the ... which Elusys says will facilitate rapid administration of antitoxin therapy to large numbers of people in an emergency ...
Antitoxin - Wikipedia
History of antitoxinEdit. Antitoxins to diphtheria and tetanus toxins were produced by Emil Adolf von Behring and his ... An antitoxin is an antibody with the ability to neutralize a specific toxin. Antitoxins are produced by certain animals, plants ... To prevent serum sickness, it is often best to use antitoxin generated from the same species (e.g. use human antitoxin to treat ... An antitoxin for scarlet fever was developed in 1924 simultaneously by Raymond Dochez and Gladys and George Frederick Dick. ...
antitoxin facts, information, pictures | Encyclopedia.com articles about antitoxin
Make research projects and school reports about antitoxin easy with credible articles from our FREE, online encyclopedia and ... antitoxin Antibody produced by the body in response to a toxin. It is specific in action and neutralizes the toxin. Antitoxin ... antitoxin An antibody produced in response to a bacterial toxin.. Cite this article Pick a style below, and copy the text for ... antitoxin (anti-toks-in) n. an antibody produced by the body to counteract a toxin formed by invading bacteria or from any ...
Patent US4722937 - Antitoxin vaginal products and catamenials - Google Patents
Species: Transcriptional regulator, AbiEi antitoxin (IPR025159) | InterPro | EMBL-EBI
CBRNE - Botulism Medication: Antitoxin therapy, Immune Globulin
Investigational antitoxin indicated for naturally occurring noninfant botulism. Equine-derived antitoxin that elicits passive ... Replaces licensed bivalent botulinum antitoxin AB (BAT-AB) and investigational monovalent botulinum antitoxin E (BAT-E). To ... Antitoxin therapy. Class Summary. Therapy consists of antibodies against toxin types A, B, C, D, E, F, and G to neutralize ... Pediatric Botulism and Use of Equine Botulinum Antitoxin in Children: A Systematic Review. Clin Infect Dis. 2017 Dec 27. 66 ( ...
Type II Toxin-Antitoxin Loci: The Unusual mqsRA Locus | SpringerLink
... locus of Escherichia coliK-12 codes for a translation-independent GCU site-specific endoribonuclease MqsR and an antitoxin MqsA ... 2011). Toxin-antitoxin systems in bacteria and archaea. Annual Review of Genetics, 45, 61-79.PubMedCrossRefGoogle Scholar ... 2011). Antitoxin MqsA helps mediate the bacterial general stress response. Nature Chemical Biology, 7(6), 359-366.PubMed ... 2010). Escherichia coli toxin/antitoxin pair MqsR/MqsA regulate toxin CspD. Environmental Microbiology, 12(5), 1105-1121.PubMed ...
Botulism antitoxin Intravenous Advanced Patient Information - Drugs.com
Detailed drug Information for botulism antitoxin Intravenous. Includes common brand names, drug descriptions, warnings, side ... Botulism Antitoxin Heptavalent ABCDEFG Equine. Uses for botulism antitoxin. Botulism antitoxin is used to treat symptoms of ... Botulism antitoxin (Intravenous). Generic Name: botulism antitoxin (BOT-ue-lizm EE-kwyne hep-ta-VAY-lent an-ti-TOX-in ABCDEFG) ... Detailed Botulism antitoxin dosage information. Precautions while using botulism antitoxin. Your doctor will check your ...
Botulism Antitoxin (Intravenous Route) Side Effects - Mayo Clinic
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:. ...
Snake venom, anti-toxins | Homeland Security Newswire
Scientists are ready to transform the production of anti-venom after mapping the DNA of the Indian cobra for the first time.. Snake bites kill more than 120,000 people a year, more than a third of them in India. About 400,000 lose limbs after amputations become necessary to prevent the spread of the venom.. The National reports that even as the number of people bitten by snakes is increasing as a result of more people living near areas which are snake habitats, the production of venom antidotes has not changed much since anti-venom was first produced in 1896.. for more than a hundred years.. The antiquated technique - involving injecting a horse with venom, then harvesting the horses blood after antibodies have been produced - is costly and imprecise. It also produces anti-venom in quantities which are insufficient for coping with the growing need for it.. A study published Monday in the journal Nature Genetics promises to help transform the process after a researchteam created a detailed map ...
USC02] 21 USC Ch. 5: VIRUSES, SERUMS, TOXINS, ANTITOXINS, AND ANALOGOUS PRODUCTS
Scarlet fever antitoxin | Definition of Scarlet fever antitoxin at Dictionary.com
Scarlet fever antitoxin definition at Dictionary.com, a free online dictionary with pronunciation, synonyms and translation. ... scarlet fever antitoxin, solid angle, solid fuel, solid geometry, solid injection, solid of revolution ... The antitoxin for the toxins produced by the bacteria that cause scarlet fever. ...
Type I toxin-antitoxin system, toxin Ldr (IPR025253) | InterPro | EMBL-EBI
They are part of the type I toxin antitoxin (TA) system, where expression of the proteinaceous toxin is controlled by an ... Type I toxin-antitoxin system, toxin Ldr (IPR025253). Short name: Toxin_Ldr ... For example, LdrD expression is inhibited by the antisense RNA RdlD, which functions as an antitoxin [PMID: 12123448]. ...
PROFESSOR DUNBAR'S ANTITOXIN TREATMENT OF HAY FEVER: A DISCLAIMER | The BMJ
A Simple Model for Assessment of Anti-Toxin Antibodies
Notice to Readers: Availability of Diphtheria Antitoxin Through an Investigational New Drug Protocol
Availability of diphtheria antitoxin through an Investigational New Drug protocol. MMWR 1997;46:380. ... Notice to Readers: Availability of Diphtheria Antitoxin Through an Investigational New Drug Protocol. ... includes early administration of an equine diphtheria antitoxin (DAT). Delay in DAT administration can lead to life-threatening ...
Transcriptional cross-activation between toxin-antitoxin systems of Escherichia coli. - PubMed - NCBI
Toxin-antitoxin systems are subject to both auto- and cross-regulation. Cognate regulatory interactions are in red and non- ... antitoxins). Antitoxins are DNA-binding proteins and auto-repress transcription of TA operons. Transcription of multiple TA ... form a tight complex and antitoxin inhibits the toxin through direct protein-protein interaction. Antitoxin, both alone and in ... Transcriptional cross-activation between toxin-antitoxin systems of Escherichia coli.. Kasari V1, Mets T, Tenson T, Kaldalu N. ...
RCSB PDB - 6M6V: Crystal structure the toxin-antitoxin MntA-HepT
Toxin-antitoxin system toxin HepN family. B, C, D. 133. Shewanella oneidensis MR-1. Mutation(s): 0 Gene Names: SO_3166. ... Toxin-antitoxin system antidote Mnt family. A. 139. Shewanella oneidensis MR-1. Mutation(s): 0 Gene Names: SO_3165. ... Novel polyadenylylation-dependent neutralization mechanism of the HEPN/MNT toxin/antitoxin system.. Yao, J., Zhen, X., Tang, K. ... The two-gene module HEPN/MNT is predicted to be the most abundant toxin/antitoxin (TA) system in prokaryotes. However, its ...
Bifunctional nanobodies with antitoxin potencies could protect against botulinum neurotoxins
New study reveals potential for developing novel antibody-based antitoxins against botulinum neurotoxins (BoNTs), including the ... Bifunctional nanobodies with antitoxin potencies could protect against botulinum neurotoxins. *Download PDF Copy ... In a nutshell, we establish a platform for structure-based rational design of bifunctional antitoxins against BoNTs. BoNTs can ... Lam, K., et al. (2020) Structural Insights into Rational Design of Single-Domain Antibody-Based Antitoxins against Botulinum ...
RCSB PDB - Protein Feature View - Antitoxin VapB26 - O53778 (VPB26 MYCTU)
Diphtheria Antitoxin (Injection Route) Description and Brand Names - Mayo Clinic
Toxins | Free Full-Text | sRNA Antitoxins: More than One Way to Repress a Toxin
The antitoxin can either be an RNA or a protein. For type I and type III loci, the antitoxins are RNAs; however, they have very ... Type I antitoxins repress toxin protein expression through interacting with the toxin mRNA, thereby targeting the mRNA for ... Along with these two very different modes of action for the antitoxin, there are differences in the functions of the toxin ... an antitoxin to repress its function or expression. ... type III antitoxins directly bind to the toxin protein, ...