Respiratory syncytial virus-induced acute and chronic airway disease is independent of genetic background: an experimental murine model. (1/5992)BACKGROUND: Respiratory syncytial virus (RSV) is the leading respiratory viral pathogen in young children worldwide. RSV disease is associated with acute airway obstruction (AO), long-term airway hyperresponsiveness (AHR), and chronic lung inflammation. Using two different mouse strains, this study was designed to determine whether RSV disease patterns are host-dependent. C57BL/6 and BALB/c mice were inoculated with RSV and followed for 77 days. RSV loads were measured by plaque assay and polymerase chain reaction (PCR) in bronchoalveolar lavage (BAL) and whole lung samples; cytokines were measured in BAL samples. Lung inflammation was evaluated with a histopathologic score (HPS), and AO and AHR were determined by plethysmography. RESULTS: Viral load dynamics, histopathologic score (HPS), cytokine concentrations, AO and long-term AHR were similar in both strains of RSV-infected mice, although RSV-infected C57BL/6 mice developed significantly greater AO compared with RSV-infected BALB/c mice on day 5. PCR detected RSV RNA in BAL samples of RSV infected mice until day 42, and in whole lung samples through day 77. BAL concentrations of cytokines TNF-alpha, IFN-gamma, and chemokines MIG, RANTES and MIP-1alpha were significantly elevated in both strains of RSV-infected mice compared with their respective controls. Viral load measured by PCR significantly correlated with disease severity on days 14 and 21. CONCLUSION: RSV-induced acute and chronic airway disease is independent of genetic background. (+info)
Genetic variation in response to an indirect ecological effect. (2/5992)Indirect ecological effects (IEEs) are widespread and often as strong as the phenotypic effects arising from direct interactions in natural communities. Indirect effects can influence competitive interactions, and are thought to be important selective forces. However, the extent that selection arising from IEEs results in long-term evolutionary change depends on genetic variation underlying the phenotypic response-that is, a genotype-by-IEE interaction. We provide the first data on genetic variation in the response of traits to an IEE, and illustrate how such genetic variation might be detected and analysed. We used a model tri-trophic system to investigate the effect of host plants on two populations of predatory ladybirds through a clonal aphid herbivore. A split-family experimental design allowed us to estimate the effects of aphid host plant on ladybird traits (IEE) and the extent of genetic variation in ladybird predators for response to these effects (genotype-by-indirect environmental effect interaction). We found significant genetic variation in the response of ladybird phenotypes to the indirect effect of host plant of their aphid prey, demonstrating the potential for evolutionary responses to selection arising from the prey host. (+info)
Poor maternal environment enhances offspring disease resistance in an invertebrate. (3/5992)Natural populations vary tremendously in their susceptibility to infectious disease agents. The factors (environmental or genetic) that underlie this variation determine the impact of disease on host population dynamics and evolution, and affect our capacity to contain disease outbreaks and to enhance resistance in agricultural animals and disease vectors. Here, we show that changes in the environmental conditions under which female Daphnia magna are kept can more than halve the susceptibility of their offspring to bacterial infection. Counter-intuitively, and unlike the effects typically observed in vertebrates for transfer of immunity, mothers producing offspring under poor conditions produced more resistant offspring than did mothers producing offspring in favourable conditions. This effect occurred when mothers who were well provisioned during their own development then found themselves reproducing in poor conditions. These effects likely reflect adaptive optimal resource allocation where better quality offspring are produced in poor environments to enhance survival. Maternal exposure to parasites also reduced offspring susceptibility, depending on host genotype and offspring food levels. These maternal responses to environmental conditions mean that studies focused on a single generation, and those in which environmental variation is experimentally minimized, may fail to describe the crucial parameters that influence the spread of disease. The large maternal effects we report here will, if they are widespread in nature, affect disease dynamics, the level of genetic polymorphism in populations, and likely weaken the evolutionary response to parasite-mediated selection. (+info)
Cytokine responses of bovine macrophages to diverse clinical Mycobacterium avium subspecies paratuberculosis strains. (4/5992)BACKGROUND: Mycobacterium avium subsp. paratuberculosis (MAP), the causative agent of Johne's disease (JD) persistently infects and survives within the host macrophages. While it is established that substantial genotypic variation exists among MAP, evidence for the correlates that associate specific MAP genotypes with clinical or sub-clinical disease phenotypes is presently unknown. Thus we studied strain differences in intracellular MAP survival and host responses in a bovine monocyte derived macrophage (MDM) system. RESULTS: Intracellular survival studies showed that a bovine MAP isolate (B1018) and a human MAP isolate (Hu6) persisted in relatively higher numbers when compared with a sheep MAP isolate (S7565) at 24-hr, 48-hr and 96-hr post infection (PI). MDMs stimulated with B1018 up-regulated IL-10 at the transcript level and down-regulated TNFalpha at the protein and transcript levels compared with stimulations by the S7565 and Hu6. MDMs infected with Hu6 showed a down regulatory pattern of IL-10 and TNFalpha compared to stimulations by S7565. Cells stimulated with B1018 and Hu6 had low levels of matrix metalloprotease-3 (MMP3) and high levels of tissue inhibitor of metalloprotease-1 (TIMP1) at 96-hr PI relative to MDMs stimulated by S7565. CONCLUSION: Taken together, results suggest that the bovine (B1018) and the human (Hu6) MAP isolates lead to anti-inflammatory and anti-invasive pathways in the macrophage environment whereas the sheep (S7565) MAP isolate induces a pro-inflammatory pathway. Thus the infecting strain genotype may play a role in polarizing the host immune responses and dictate the clinicopathological outcomes in this economically important disease. (+info)
Compositional discordance between prokaryotic plasmids and host chromosomes. (5/5992)BACKGROUND: Most plasmids depend on the host replication machinery and possess partitioning genes. These properties confine plasmids to a limited range of hosts, yielding a close and presumably stable relationship between plasmid and host. Hence, it is anticipated that due to amelioration the dinucleotide composition of plasmids is similar to that of the genome of their hosts. However, plasmids are also thought to play a major role in horizontal gene transfer and thus are frequently exchanged between hosts, suggesting dinucleotide composition dissimilarity between plasmid and host genome. We compared the dinucleotide composition of a large collection of plasmids with that of their host genomes to shed more light on this enigma. RESULTS: The dinucleotide frequency, coined the genome signature, facilitates the identification of putative horizontally transferred DNA in complete genome sequences, since it was found to be typical for a certain genome, and similar between related species. By comparison of the genome signature of 230 plasmid sequences with that of the genome of each respective host, we found that in general the genome signature of plasmids is dissimilar from that of their host genome. CONCLUSION: Our results show that the genome signature of plasmids does not resemble that of their host genome. This indicates either absence of amelioration or a less stable relationship between plasmids and their host. We propose an indiscriminate lifestyle for plasmids preserving the genome signature discordance between these episomes and host chromosomes. (+info)
Protein synthesized by dengue infected Aedes aegypti and Aedes albopictus. (6/5992)The main objective of this study was to compare protein profiles of whole mosquitoes of Malaysian Aedes aegypti and Aedes albopictus after infection with virus and to investigate whether dengue virus would induce protein secretion in Ae. aegypti and Ae. albopictus. Using SDS -PAGE, it was shown that in uninfected Ae. aegypti and Ae. albopictus, the protein bands were within the range of 14 - 80 kDa with most of the bands overlapping for the two species. Comparison of the protein profile of infected and uninfected Ae. aegypti and Ae. albopictus showed five distinct molecular weight grouping at 73 - 76 kDa (Group 1), 44 - 50 kDa (Group 2), 28 - 31 kDa (Group 3), 20 - 25 kDa (Group 4) and 14 - 17 kDa (Group 5). Predominant bands for both species (infected and uninfected) were between 21 - 25 kDa and 44 - 50 kDa. Protein bands having a molecular weight of 70 kDa were only present in infected Ae. albopictus and those bands having molecular weight of 21 kDa were observed only in infected Ae. aegypti. The rate of digestion of blood meals was more rapid in Ae. albopictus than Ae. aegypti. Uninfected Ae. albopictus completed the blood digestion 2 days after ingestion of a blood meal whereas Ae. aegypti needed 3 days to complete the digestion. The rate of digestion for blood meals was slower for both mosquito species when fed with dengue virus infected blood. The digestion processes were completed 3 and 4 days after blood ingestion for Ae. albopictus and Ae. aegypti, respectively. This could be due to the presence of dengue virus in the blood, which slow down the digestion process. Appearance and disappearance of new protein bands was also observed even after the digestion has completed for both infected mosquito species. In conclusion, dengue virus was shown to induce specific proteins in both Ae. aegypti and Ae. albopictus. (+info)
Association and host selectivity in multi-host pathogens. (7/5992)The distribution of multi-host pathogens over their host range conditions their population dynamics and structure. Also, host co-infection by different pathogens may have important consequences for the evolution of hosts and pathogens, and host-pathogen co-evolution. Hence it is of interest to know if the distribution of pathogens over their host range is random, or if there are associations between hosts and pathogens, or between pathogens sharing a host. To analyse these issues we propose indices for the observed patterns of host infection by pathogens, and for the observed patterns of co-infection, and tests to analyse if these patterns conform to randomness or reflect associations. Applying these tests to the prevalence of five plant viruses on 21 wild plant species evidenced host-virus associations: most hosts and viruses were selective for viruses and hosts, respectively. Interestingly, the more host-selective viruses were the more prevalent ones, suggesting that host specialisation is a successful strategy for multi-host pathogens. Analyses also showed that viruses tended to associate positively in co-infected hosts. The developed indices and tests provide the tools to analyse how strong and common are these associations among different groups of pathogens, which will help to understand and model the population biology of multi-host pathogens. (+info)
Is adipose tissue a place for Mycobacterium tuberculosis persistence? (8/5992)BACKGROUND: Mycobacterium tuberculosis, the etiological agent of tuberculosis (TB), has the ability to persist in its human host for exceptionally long periods of time. However, little is known about the location of the bacilli in latently infected individuals. Long-term mycobacterial persistence in the lungs has been reported, but this may not sufficiently account for strictly extra-pulmonary TB, which represents 10-15% of the reactivation cases. METHODOLOGY/PRINCIPAL FINDINGS: We applied in situ and conventional PCR to sections of adipose tissue samples of various anatomical origins from 19 individuals from Mexico and 20 from France who had died from causes other than TB. M. tuberculosis DNA could be detected by either or both techniques in fat tissue surrounding the kidneys, the stomach, the lymph nodes, the heart and the skin in 9/57 Mexican samples (6/19 individuals), and in 8/26 French samples (6/20 individuals). In addition, mycobacteria could be immuno-detected in perinodal adipose tissue of 1 out of 3 biopsy samples from individuals with active TB. In vitro, using a combination of adipose cell models, including the widely used murine adipose cell line 3T3-L1, as well as primary human adipocytes, we show that after binding to scavenger receptors, M. tuberculosis can enter within adipocytes, where it accumulates intracytoplasmic lipid inclusions and survives in a non-replicating state that is insensitive to the major anti-mycobacterial drug isoniazid. CONCLUSIONS/SIGNIFICANCE: Given the abundance and the wide distribution of the adipose tissue throughout the body, our results suggest that this tissue, among others, might constitute a vast reservoir where the tubercle bacillus could persist for long periods of time, and avoid both killing by antimicrobials and recognition by the host immune system. In addition, M. tuberculosis-infected adipocytes might provide a new model to investigate dormancy and to evaluate new drugs for the treatment of persistent infection. (+info)
Depending on how the pathogen interacts with the host, it can be involved in one of three host-pathogen interactions. ... Virus-Host protein-protein interaction Networks knowledgebase PHI-base - Pathogen-Host Interaction Database Virus Human ... The host-pathogen interaction is defined as how microbes or viruses sustain themselves within host organisms on a molecular, ... As we learn more about the host-pathogen interaction and the amount of variability within hosts, the definition of the ...
Yamazaki, N.; Fry, S. C.; Darvill, A. G.; Albersheim, P. (1983). "Host-pathogen interactions: XXIV. Fragments isolated from ... form and host-pathogen relations. The association of WAKs with The Plant Cell wall was first compromised by immunolocalization ... A pathogen's path to infection begins with the cell wall; the proteins that connect the cell wall to the plasma membrane are ... The interaction of pectin polyanion with the cell wall or plasmalemma could induce conformational changes in the pectin ...
Mitochondrial outer membrane permeabilization
Fung, To Sing; Liu, Ding Xiang (2019). "Human Coronavirus: Host-Pathogen Interaction". Annual Review of Microbiology. 73: 529- ...
"Center for Host-Pathogen Interaction". Department of Pediatrics. 21 July 2020. Retrieved 7 July 2022. "CNN.com - Expert: Window ... "Center for Host-Pathogen Interaction". Department of Pediatrics. 21 July 2020. Retrieved 7 July 2022. "Public Affairs". ... where she directs the Center for Host Pathogen Interaction. In 2022, Moscona was elected as president of the American Society ... PLOS Pathogens. 6 (10): e1001168. doi:10.1371/journal.ppat.1001168. ISSN 1553-7374. PMC 2965769. PMID 21060819. Outlaw, Victor ...
Human coronavirus HKU1
Fung, To Sing; Liu, Ding Xiang (2019). "Human Coronavirus: Host-Pathogen Interaction". Annual Review of Microbiology. 73: 529- ... A Review of Virus-Host Interactions". Diseases. 4 (3): 26. doi:10.3390/diseases4030026. ISSN 2079-9721. PMC 5456285. PMID ... A Review of Virus-Host Interactions". Diseases. 4 (3): 26. doi:10.3390/diseases4030026. ISSN 2079-9721. PMC 5456285. PMID ... The virus is an enveloped, positive-sense, single-stranded RNA virus which enters its host cell by binding to the N-acetyl-9-O- ...
1999, with Liise-anne Pirofski, Host-pathogen interactions: redefining the basic concepts of virulence and pathogenicity , in: ... Casadevall, Arturo; Pirofski, Liise-anne (1999). "Host-pathogen interactions: redefining the basic concepts of virulence and ... Casadevall, Arturo; Pirofski, Liise-anne (2001). "Host-pathogen interactions: the attributes of virulence". The Journal of ... Casadevall, Arturo; Pirofski, Liise-anne (2000). "Host-Pathogen Interactions: The basic concepts of microbial commensalism, ...
Dheilly, Nolwenn Marie (2014-07-03). "Holobiont-Holobiont Interactions: Redefining Host-Parasite Interactions". PLOS Pathogens ... Examples include gut microbe or viral genomes linked to human or animal genomes for host-microbe interaction research. ... have been found with holobiont-holobiont interactions. Maturation of mammalian host immune systems has been known to involve ... hologenomics uses an integrative framework to investigate interactions between the host and its associated species. ...
"Transcript Profiling in Host-Pathogen Interactions". Annual Review of Phytopathology. 45 (1): 329-369. doi:10.1146/annurev. ... Bogdanove's present research focuses on the pathogen Xanthomonas oryzae and its interactions with species of rice. "People in ... understanding bacterium-plant interactions". Nature Reviews Microbiology. 9 (5): 344-355. doi:10.1038/nrmicro2558. PMID ... portion of his work uncovered the mechanisms by which TAL effectors increase disease susceptibility by manipulating host gene ...
Herbivore adaptations to plant defense
Host response to bark beetle and pathogen colonization. Pages 157 - 173 in T. Schowalter, editor. Beetle-pathogen interactions ... Manipulation of host plant quality: Herbivores keep leaves in the dark. Functional Ecology 6:741 - 743. Sandberg, S. L., and M ... Host specialization in phytophagous insects. Annual Review of Ecology and Systematics 21:243 - 273. Mallet, J., & Porter, P. ... Polyphagy often develops when a herbivore's host plants are rare as a necessity to gain enough food. Monophagy is favored when ...
"Host-Pathogen Interaction During Bacterial Vaccination". Current Opinion in Immunology. 36: 1-7. doi:10.1016/j.coi.2015.04.002 ... the host's immune system is no longer able to recognize and eliminate a pathogen, such as a virus. This process can occur in a ... While a host's homologous recombination can act as a defense mechanisms for fixing DNA double stranded breaks (DSBs), it can ... This results in the pathogens being able to attack targets of the immune system different than those intended to be targeted by ...
The applications range from understanding host-pathogen interactions and infectious diseases, cancer, to understanding better ... "Multi-Omics Strategies Uncover Host-Pathogen Interactions". ACS Infectious Diseases. 5 (4): 493-505. doi:10.1021/acsinfecdis. ... Innovating the Pathogen-Host Research Paradigm". mBio. 2 (1): e00325-10. doi:10.1128/mbio.00325-10. ISSN 2150-7511. PMC 3034460 ... The complexity of interactions in the human immune system has prompted the generation of a wealth of immunology-related multi- ...
Candida albicans proteinases and host/pathogen interactions. Cellular Microbiology Volume 6, Issue 10, pages 915-926, October ... candida albicans is a good pathogen. Host adaptation can also be used in reference to the host. Hosts have the ability to adapt ... Pathogens like Salmonella, which is a food borne pathogen, are able to adapt to the host environment and maintain virulence via ... In this case, the ability or lack thereof of a pathogen to adapt to its host environment is an indicator of the pathogen's ...
"Using the pathogen-host interactions database (PHI-base) to investigate plant pathogen genomes and genes implicated in ... The Pathogen-Host Interactions database was developed to utilise effectively the growing number of verified genes that mediate ... The Pathogen-Host Interactions database (PHI-base) is a biological database that contains curated information on genes ... Urban, M.; Pant, R.; Raghunath, A.; Irvine, A.G.; Pedro, H.; Hammond-Kosack, K.E. (2015). "The Pathogen-Host Interactions ...
Doherty CP (May 2007). "Host-pathogen interactions: the role of iron". The Journal of Nutrition. 137 (5): 1341-4. doi:10.1093/ ... Skaar EP (2010). "The battle for iron between bacterial pathogens and their vertebrate hosts". PLOS Pathogens. 6 (8): e1000949 ... which are iron-binding chelators made by microorganisms.Iron serves as a key nutrient in host-pathogen interactions, and ... To evade the host defences, pathogens evolved to produce structurally varied siderophores that would not be recognized by ...
Alex K. Shalek
... host cell-pathogen interactions evolve during infection;[excessive citations] and, tumor cells evade therapeutic treatment and ... 2020-11-25). "Single-Cell Profiling of Ebola Virus Disease In Vivo Reveals Viral and Host Dynamics". Cell. 183 (5): 1383-1401. ... "Single-Cell Profiling of Ebola Virus Disease In Vivo Reveals Viral and Host Dynamics". Cell. 183 (5): 1383-1401.e19. doi: ... and nanotechnology to establish accessible approaches to profile and control cells and their interactions. In addition to these ...
Flor HH (1955). "Host-parasite interaction in flax rust - its genetics and other implications". Phytopathology. 45: 680-685. ... Whitham SA, Qi M, Innes RW, Ma W, Lopes-Caitar V, Hewezi T (August 2016). "Molecular Soybean-Pathogen Interactions". Annual ... DeYoung BJ, Innes RW (December 2006). "Plant NBS-LRR proteins in pathogen sensing and host defense". Nature Immunology. 7 (12 ... In contrast, for the NBS-LRR class of R genes, direct interaction has not been shown for most of the R/avr pairs. This lack of ...
Hovius JW, van Dam AP, Fikrig E (September 2007). "Tick-host-pathogen interactions in Lyme borreliosis" (PDF). Trends in ... The white-footed mouse is a reservoir host in which the pathogen for Lyme disease can survive. Availability of hosts can have ... A greater diversity of hosts, or of those that don't support the pathogen, tends to decrease the likelihood that the disease ... Some species, such as lizards, are referred to as "dilution hosts" because they don't tend to support Lyme disease pathogens ...
She studies host and pathogen interactions and epidemiology. She won the 2018 Royal Society Africa Prize. Yeboah-Manu is from ... "NATIONAL FACULTY - West African Centre for Cell Biology of Infectious Pathogens". www.waccbip.org. Archived from the original ... the National Faculty of the World Bank Centre of Excellence funded West African Centre for Cell Biology of Infectious Pathogens ...
Clarke, Margaret (2010). "Recent insights into host-pathogen interactions from Dyctiostelium". Cellular Microbiology. 12 (3): ... Sentinel cells are present in the slug even when there are no toxins or pathogens to be removed. Sentinel cells have been ... D. discoideum is also a host for Legionella and is a suitable model for studying the infection process. Specifically, D. ... Free-living amoebae seem to play a crucial role for persistence and dispersal of some pathogens in the environment. Transient ...
"Host Recognition by Fungal Pathogens". In San-Blas, Gioconda; Calderone, Richard A. (eds.). Pathogenic Fungi: Host Interactions ... The pathogen enters hosts through developing roots, where it can infect the host. After infection, F. solani produces asexual ... The pathogen can persist in the soil for a decade, and if left unchecked can cause complete crop loss. The ubiquitous nature of ... Recently the pathogen has also done serious damage to olive trees throughout the mediterranean. F. solani has ...
... and their insect hosts". Parasites and Pathogens of Insects. Volume 2: Pathogens. Academic Press. ISBN 978-0120844425. Lu, D., ... Akhurst, RJ; Dunphy, GB (1993). "Tripartite interactions between symbiotically associated entomopathogenic bacteria, nematodes ... All other life stages (L1, L2, L3, L4, and adult) occur within an insect host. The IJ enters the host through natural openings ... After the death of the host, nematodes continue to feed on the host tissue and the multiplying bacteria. They develop into ...
"Host-pathogen interaction during pneumococcal infection in patients with chronic obstructive pulmonary disease". Infection and ... Host-pathogen interaction during Streptococcus pneumoniae colonization and infection. Wikidata: Q108731858 (thesis) Debby ...
PHI-base: a database of multiple pathogen-host interactions. In 2012 Rothamsted started testing genetically modified wheat ... Additions to the pathogen host interaction database". Nucleic Acids Research. 36 (Database issue): D572-D576. doi:10.1093/nar/ ...
... and Host-Pathogen Interactions". Trends in Microbiology. 29 (5): 458-471. doi:10.1016/j.tim.2020.09.003. hdl:1885/219768. PMID ... These enterotoxins are all produced in the small intestine of the host, thus thwarting digestion by host endogenous enzymes. ... Gillis A, Mahillon J (July 2014). "Prevalence, genetic diversity, and host range of tectiviruses among members of the Bacillus ... Bottone EJ (April 2010). "Bacillus cereus, a volatile human pathogen". Clinical Microbiology Reviews. 23 (2): 382-398. doi: ...
Vesicle (biology and chemistry)
In host-pathogen interactions, gram negative bacteria produce vesicles which play roles in establishing a colonization niche, ... Kuehn MJ, Kesty NC (November 2005). "Bacterial outer membrane vesicles and the host-pathogen interaction". Genes & Development ... Bleb (cell biology) Host-pathogen interface Membrane contact sites Membrane nanotube Membrane vesicle trafficking Micelle ... carrying and transmitting virulence factors into host cells and modulating host defense and response. Ocean cyanobacteria have ...
Kuehn, M.J.; Kesty, N.C. (2005). "Bacterial outer membrane vesicles and the host-pathogen interaction". Genes & Development. 19 ... It was discovered in Agrobacterium tumefaciens, which uses this system to introduce the Ti plasmid and proteins into the host, ... PLOS Pathogens. 4 (1): e8. doi:10.1371/journal.ppat.0040008. PMC 2211552. PMID 18208324. Miserez, A; Li, Y; Waite, H; Zok, F ( ... pestis and showed that toxins could be injected directly from the bacterial cytoplasm into the cytoplasm of its host's cells ...
Kuehn MJ, Kesty NC (November 2005). "Bacterial outer membrane vesicles and the host-pathogen interaction". Genes & Development ... Bacterial effector protein Bacterial outer membrane vesicles Host-pathogen interface Membrane vesicle trafficking Secretomics ... The Hrp system in plant pathogens inject harpins and pathogen effector proteins through similar mechanisms into plants. This ... and are deployed for membrane vesicle trafficking to manipulate environment or invade at host-pathogen interface. Vesicles from ...
The transparent early life stages are well suited for in vivo imaging and genetic dissection of host-pathogen interactions. ... Meijer AH, Spaink HP (June 2011). "Host-pathogen interactions made transparent with the zebrafish model". Current Drug Targets ... "Macrophage-pathogen interactions in infectious diseases: new therapeutic insights from the zebrafish host model". Disease ... Meijer AH, van der Vaart M, Spaink HP (January 2014). "Real-time imaging and genetic dissection of host-microbe interactions in ...
List of people associated with Utrecht University
Host-pathogen interaction during Streptococcus pneumoniae colonization and infection. p. 349. OCLC 66590154. de:Jan Ackersdijck ...
"Protozoa lectins and their role in host-pathogen interactions". Biotechnology Advances. 34 (5): 1018-1029. doi:10.1016/j. ... Anti-adhesion therapy can be used to prevent infection by targeting adhesion molecules either on the pathogen or on the host ... These molecules also control host specificity and regulate tropism (tissue- or cell-specific interactions) through their ... either through protein-protein or protein-carbohydrate interactions, to host cells or fibronectins in the extracellular matrix ...
... and may occur as opportunistic pathogens of vertebrate hosts, such as Exophiala (Wangiella) dermatitidis. Several species are ... Insights into a newly discovered world of symbiotic interactions". Fungal Biology. 115 (10): 1077-91. doi:10.1016/j.funbio. ... Gostinčar, C.; Grube, M.; Gunde-Cimerman, N. (2011). "Evolution of Fungal Pathogens in Domestic Environments?". Fungal Biology ... "A rock-inhabiting ancestor for mutualistic and pathogen-rich fungal lineages". Studies in Mycology. 61: 111-9. doi:10.3114/sim. ...
Melon necrotic spot virus
MNSV can be found in tropical and temperate areas in the world where its host crops thrive. The first symptoms sighting of MNSV ... For over four decades, this pathogen has proven to be important due to the agricultural community's lack of knowledge on MNSV ... In: XIII International Congress on Molecular Plant-Microbe Interactions. Italy: Sorrento, 281. Campbell, R. (1996). "Vector- ... Once the fungus invades the plant roots it transmits the virus to the host plants. The processes is then repeated once seeds ...
Coronavirus nucleocapsid protein
"Multiple Roles of SARS-CoV-2 N Protein Facilitated by Proteoform-Specific Interactions with RNA, Host Proteins, and ... PLOS Pathogens. 16 (12): e1009100. doi:10.1371/journal.ppat.1009100. PMC 7735635. PMID 33264373. Fung, To Sing; Liu, Ding Xiang ... In addition to its interactions with RNA, N forms protein-protein interactions with the coronavirus membrane protein (M) during ... Type I PRMT inhibitor (MS023) or substitution of R95 or R177 with lysine inhibited interaction of N protein with the 5'-UTR of ...
Lawrence JG (December 2005). "Common themes in the genome strategies of pathogens". Current Opinion in Genetics & Development. ... lack all amino acid synthesis and take their amino acids directly from their hosts. All amino acids are synthesized from ... of the metabolic networks in cells that contain thousands of different enzymes is given by the figure showing the interactions ... Wipperman MF, Sampson NS, Thomas ST (2014). "Pathogen roid rage: cholesterol utilization by Mycobacterium tuberculosis". ...
YqaJ protein domain
... evolved as a portable module that can function wide variety of host organisms without requiring extensive interaction with host ... This offers the pathogen a great adaptive advantage on viruses exploring new niches. Vellani TS, Myers RS (April 2003). " ... Most viruses, inject their host with linear DNA, and this gets incorporated into the host genome through the process of ...
... s (IFNs, /ˌɪntərˈfɪərɒn/) are a group of signaling proteins made and released by host cells in response to the ... PLOS Pathogens. 16 (7): e1008737. doi:10.1371/journal.ppat.1008737. PMC 7390284. PMID 32726355. Toor SM, Saleh R, Elkord E ( ... "System-level comparison of protein-protein interactions between viruses and the human type I interferon system network". ... Seo SH, Hoffmann E, Webster RG (September 2002). "Lethal H5N1 influenza viruses escape host anti-viral cytokine responses". ...
Wikel, Stephen (2018-06-20). "Ticks and Tick-Borne Infections: Complex Ecology, Agents, and Host Interactions". Veterinary ... and the host may or may not carry the transmittable pathogen. An example of these concepts can be found in the Deer Tick, known ... Ticks often have a preferred host, but may still attach to a different host when called for. Their preferred host may change ... Ticks use various tactics to reach their target host. Sometimes they employ a crawl-like movement to move towards their host. ...
Diseases of poverty
Rowland-Jones SL, Lohman B (October 2002). "Interactions between malaria and HIV infection-an emerging public health problem ... Borkow G, Bentwich Z (May 2002). "Host background immunity and human immunodeficiency virus protective vaccines, a major ... Contaminated water enables the spread of various waterborne-pathogens, including bacteria (E. coli, cholera), viruses ( ... Harms G, Feldmeier H (June 2002). "HIV infection and tropical parasitic diseases - deleterious interactions in both directions ...
"Betulin derivatives impair Leishmania braziliensis viability and host-parasite interaction". Bioorganic & Medicinal Chemistry. ... PLOS Pathogens. 6 (8): e1001004. doi:10.1371/journal.ppat.1001004. PMC 2924324. PMID 20808896. Oryan, A.; Akbari, M. (October ... It is an infectious disease that is spread by a parasite in sandflies that use domestic dogs as hosts. The emergence of ... Leishmania braziliensis, like other species of Leishmania rely on asexual reproduction in the intermediate mammalian host to ...
... also have additional effects on cellular metabolism and homeostasis mediated by protein-protein interactions with host cell ... PLOS Pathogens. 6 (3): e1000801. doi:10.1371/journal.ppat.1000801. PMC 2837404. PMID 20300659. Wetherill LF, Holmes KK, Verow M ... Viroporins are capable of assembling into oligomeric ion channels or pores in the host cell's membrane, rendering it more ... For example, the HIV-1 viroporin Vpu promotes viral budding through interactions with CD4 and tetherin, though the precise ...
"A role for host-parasite interactions in the horizontal transfer of DNA transposons across animal phyla". Nature. 464 (7293): ... Insect vectors of human pathogens, Chagas disease, Insects described in 1859, Insects of South America). ... The parasite enters the victim through the bite wound after the human host scratches the bite. Infection may also occur via ... It has been implicated in the transmission of transposons between it and some of its vertebrate hosts, squirrel monkeys and ...
The parasitic pathogen is transmitted through the bite of a sandfly, and although humans can be infected, humans cannot spread ... At any given moment, the number of male flies far outweighs the number of female flies present on a chicken host, which is ... Arthropod-Plant Interactions 5, 9-18 (2010). (Articles with short description, Short description is different from Wikidata, ... The microbiome of the midgut is a critical factor that influences the growth of the pathogen into its infective state. Sucrose- ...
Toll-like receptor 6
May 2011). "Synergistic interactions of TLR2/6 and TLR9 induce a high level of resistance to lung infection in mice". Journal ... They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the ... Mukherjee S, Huda S, Sinha Babu SP (July 2019). "Toll-like receptor polymorphism in host immune response to infectious diseases ... Synergistic interactions of TLR2/6 and TLR9 leading to higher resistance against lung infection have also been reported. Unlike ...
They usually emerge from hibernation later than their host species. Each species of cuckoo bee has a specific host species, ... In North America, pathogens are possibly having a stronger negative effect especially for the subgenus Bombus. A major impact ... Whitney, H.; Dyer, A.; Rands, S.A.; Glover, B.J. (2008). "The interaction of temperature and sucrose concentration on foraging ... Female cuckoo bumblebees aggressively attack host colony members, and sting the host queen, but ignore other animals unless ...
... are an essential component of the host's innate immune system with various antimicrobial defense mechanisms to clear pathogens ... Liautard, JP; Gross, A; Dornand, J; Köhler, S (June 1996). "Interactions between professional phagocytes and Brucella spp". ... B. suis, in return, has developed ways to counteract the host cell defense to survive in the macrophage and to deter host ... The only effective way to control and eradicate zoonosis is by vaccination of all susceptible hosts and elimination of infected ...
Cellular interaction The cellular interactions are referring to the interaction between the hyphae and the host plant cells. ... Ustilaginomycotina have an array of plant pathogens, and some are parasitizing on economically important species like wheat, ... The host-interactions zones can either be local interaction zones and then characterizing the Exobasidiomycetes, or enlarged ... But not all taxa in Ustilaginomycotina are host-specific, some have a broad host range and others have also made a host jump to ...
Ribet D, Cossart P (November 2018). "Ubiquitin, SUMO, and NEDD8: Key Targets of Bacterial Pathogens" (PDF). Trends in Cell ... Zhou Y, Zhu Y (January 2015). "Diversity of bacterial manipulation of the host ubiquitin pathways". Cellular Microbiology. 17 ( ... and may be proteolytically processed to release the UBL domain or may function as protein-protein interaction domains. UBL ... some pathogenic bacteria have evolved proteins that mimic those in eukaryotic UBL pathways and interact with UBLs in the host ...
Yi Liu, Danyu Kong, Hui-Lan Wu, Hong-Qing Ling, Iron in plant-pathogen interactions. (2021) Journal of Experimental Botany, ... iron uptake contributes to the optimum virulence of Xanthomonas oryzicola and Xanthomonas campestris on their respective hosts ... Guerra, G.S., Balan, A. Genetic and structural determinants on iron assimilation pathways in the plant pathogen Xanthomonas ... However, the xanthoferrin synthesis genes are conserved throughout the members of Xanthomonas group of plant pathogens and ...
Pham DQ, Pham AQ (March 2007). "Interaction potential between cranberry juice and warfarin". Am J Health Syst Pharm. 64 (5): ... The State University of New Jersey University of Massachusetts Cranberry Station Hosted by the University of Massachusetts - ... material that is under research for its potential to affect formation of plaque by Streptococcus mutans pathogens that cause ... University of Massachusetts Amherst Cranberry Station for information on cranberry research Cranberry Library Page Hosted by ...
Foods are often irradiated to kill harmful pathogens. There are two types of radiations that are used to inhibit the growth of ... Like all therapeutic antimicrobials, they must kill the infecting organism without serious damage to the host.[citation needed ... and Jules Francois Joubert observed antagonism between some bacteria and discussed the merits of controlling these interactions ... Prestinaci F, Pezzotti P, Pantosti A (October 2015). "Antimicrobial resistance: a global multifaceted phenomenon". Pathogens ...
... and another stage where it parasitizes as a primary host a cod or other fishes of the cod family (gadoids). It is a pathogen ... Final report of the Aquaculture Health Joint Working Group sub-group on disease risks and interactions between farmed salmonids ... "From host to host". An Introduction to Parasitology. Cambridge University Press. pp. 52-78. ISBN 978-0-521-57691-8. Ross Piper ... The oral end of the female copepod penetrates the body of the cod until it enters the rear bulb of the host's heart. There, ...
The pathogen is host specific and further testing can be done to corroborate the initial identification. Certain polymerase ... These toxins are marked for their detrimental interaction with a particular host species while potentially having no effect on ... The tissue being damaged on the host becomes a source of nutrient for the pathogen to grow and cause more symptoms. A potential ... The pathogen is currently limited to the P. Americana species but is able to infect all three cultivars. The resulting disease ...
Vizoso, D. B.; Ebert, D. (2005-07-01). "Phenotypic plasticity of host-parasite interactions in response to the route of ... "Draft genome sequence of the Daphnia pathogen Octosporea bayeri: insights into the gene content of a large microsporidian ... Thereby it can be kept in a population even though the host is resting while the habitat is dried up or frozen. Because of its ... Genetic differences in host susceptibility have been suggested to contribute to the geographic distribution of H. ...
Ibelings, B.W.; de Bruin, A.; Kagami, M.; Rijkeboer, M.; van Donk, E. (2004). "Host parasite interactions between freshwater ... Chytrids may also infect plant species; in particular, Synchytrium endobioticum is an important potato pathogen. Arguably, the ... This group includes the notable plant pathogens Synchytrium. Some algal parasites practice oögamy: A motile male gamete ...
Pattern recognition receptor
McDonald C, Nuñez G (2005). "NOD-LRR proteins: role in host-microbial interactions and inflammatory disease". Annual Review of ... PRRs are germline-encoded host sensors, which detect molecules typical for the pathogens. They are proteins expressed, mainly, ... Chisholm ST, Coaker G, Day B, Staskawicz BJ (February 2006). "Host-microbe interactions: shaping the evolution of the plant ... pathogen-associated molecular patterns (PAMPs), which are associated with microbial pathogens, and damage-associated molecular ...
Within the first minute the van der Waals interaction causes the submerged surface to be covered with a conditioning film of ... Such accumulation is referred to as epibiosis when the host surface is another organism and the relationship is not parasitic. ... While these systems sometimes include HEPA filters to collect microbes, some pathogens do pass through these filters, collect ... 2001), "Hydrophobicity in Bacterial Adhesion", Biofilm community interactions: chance or necessity? (PDF), BioLine, ISBN 978- ...
These interactions can contribute to the growth of pathogenic bacteria such as Clostridium difficile, which uses sialic acid as ... It is one of the most common bacteria found in human gut microbiota and is also an opportunistic pathogen. Its genome contains ... As a component of the human gut flora, it can use both dietary carbohydrates and those sourced from the host, depending on ... Similar interactions can cause B. thetaiotaomicron to exacerbate pathogenic E. coli infection. Daniel Ryan; Laura Jenniches; ...
eDNA has been used to study species while minimizing any stress inducing human interaction, allowing researchers to monitor ... host plant and predatory diet identification from insect DNA extracts, and predator scat from bats. Recently, also DNA from ... PLOS Pathogens. 4 (11): e1000213. doi:10.1371/journal.ppat.1000213. PMC 2581603. PMID 19023416. Berne C, Kysela DT, Brun YV ( ... The selfDNA phenomenon has been postulated to drive ecological interactions and to be mechanistically mediated by damage- ...
Her research considers host-pathogen interactions, with a particular focus on the Bacillus cereus group species. As an ... She currently serves as Associate Editor of PLOS Pathogens. She is Chair of the National Institutes of Health Review Group on ... "PLOS Pathogens: A Peer-Reviewed Open-Access Journal". journals.plos.org. Retrieved February 22, 2022. "Theresa Koehler". ...
Host-pathogen interactions - UMC Utrecht
Direct detection of bacteremia by exploiting host-pathogen interactions of lipoteichoic acid and lipopolysaccharide |...
Taken together, these results demonstrate the significance of biochemistry in both our understanding of host-pathogen biology, ... Specifically, we have exploited the interaction of amphiphilic pathogen biomarkers such as lipopolysaccharides (LPS) from ... we have developed and clinically validated a novel method for the direct detection of amphiphilic pathogen biomarkers ... Gram-negative bacteria and lipoteichoic acids (LTA) from Gram-positive bacteria with host lipoprotein carriers in blood, ...
Comparative genomics and transcriptomics of host-pathogen interactions in insects: evolutionary insights and future directions
Sackton, Timothy B. "Comparative Genomics and Transcriptomics of Host-pathogen Interactions in Insects: Evolutionary Insights ... it is becoming clear that duplications and losses of immune genes are also a likely consequence of host-pathogen interactions. ... are crucial for additional progress in understanding the ecology and evolution of the full complexity of the host response. ...
Silica-coated phosphorescent nanoprobes for selective cell targeting and dynamic bioimaging of pathogen-host cell interactions ...
We specifically explore their suitability for dynamic in vitro bioimaging of interactions between bacterial pathogens and host ... Silica-coated phosphorescent nanoprobes for selective cell targeting and dynamic bioimaging of pathogen-host cell interactions ... Silica-coated phosphorescent nanoprobes for selective cell targeting and dynamic bioimaging of pathogen-host cell interactions† ...
British Library EThOS: Characterisation of host determinants that influence host-pathogen interaction during infection with...
Cold Spring Harbor Meeting on Host Pathogen Interactions - University of East Anglia
host-pathogen interactions - Engineering Evil
Biological Science (with foundation year)
Organ‐on‐chip to investigate host‐pathogens interactions - Institut Pasteur
This topic reaches a new era towards the study of host-pathogen interactions mechanisms at the tissue scale. The past few years ... and the interface of a tissue and how this particular microenvironment is critical to study host-pathogen interactions. ... This topic reaches a new era towards the study of host-pathogen interactions mechanisms at the tissue scale. The past few years ... Organ‐on‐chip to investigate host‐pathogens interactions. Cellular Microbiology, 2021, 23 (7), pp.e13336. ⟨10.1111/cmi.13336⟩. ...
Elucidating the Stoichiometries of Host-Pathogen Protein Interactions with Mass Photometry. | Methods Mol Biol;2674: 201-208,...
Binding stoichiometry; Host-pathogen interaction; M protein; Mass photometry; Oligomerization; PAM; Plasminogen; Polydispersity ... Elucidating the Stoichiometries of Host-Pathogen Protein Interactions with Mass Photometry Elucidating the Stoichiometries of ... Host-Pathogen Protein Interactions with Mass Photometry. Proctor, Emma-Jayne; Satapathy, Sandeep; Sanderson-Smith, Martina. ...
Curation application for PHI-base, the Pathogen-Host Interactions database - Log in to continue
Pathogen-driven cancers from a structural perspective: Targeting host-pathogen protein-protein interactions<...
N2 - Host-pathogen interactions (HPIs) affect and involve multiple mechanisms in both the pathogen and the host. Pathogen ... AB - Host-pathogen interactions (HPIs) affect and involve multiple mechanisms in both the pathogen and the host. Pathogen ... Host-pathogen interactions (HPIs) affect and involve multiple mechanisms in both the pathogen and the host. Pathogen ... "Host-pathogen interactions (HPIs) affect and involve multiple mechanisms in both the pathogen and the host. Pathogen ...
Scientist Search Results | HHMI
The virome in mammalian physiology and disease
The mammalian virome is constituted of viruses that infect host cells, virus-derived elements in our chromosomes, and viruses ... Virome interactions with the host cannot be encompassed by a monotheistic view of viruses as pathogens. Instead, the genetic ... The mammalian virome is constituted of viruses that infect host cells, virus-derived elements in our chromosomes, and viruses ...
zoonosis research • School of Veterinary Medicine at the Freie Universität Berlin
Pathogen/host interactions and zoonosis research. Pathogen/host Interactions and Zoonosis Research. The interdisciplinary ... This research training group handles possible interactions between pathogens and their hosts at the molecular level. ... of porcine pathogens that may have a financial and health impact. ... on different projects to analyze major food-borne pathogens ...
RNA Biology: Viral RNA: A Swiss Army Knife at the Center of Host/Pathogen Interactions and the Pathogenesis of RNA Viruses -...
Viral RNA: A Swiss Army Knife at the Center of Host/Pathogen Interactions and the Pathogenesis of RNA Viruses. As obligate ... Viral RNA: A Swiss Army Knife at the Center of Host/Pathogen Interactions and the Pathogenesis of RNA Viruses. ... A better understanding of these virus/host interactions is relevant not only for identifying therapeutic targets and ... through interactions between viral RNAs and host RNA-binding proteins. This is especially true for some RNA viruses which must ...
Interests: molecular diagnostics; real-time PCR; point-of-care test; virology; virus-host interaction; pathogen surveillance; ... Interests: respiratory viruses; neuroinvasion; CNS; coronavirus; antivirals; virus-host interaction; viral cell-to-cell ... Special Issue in International Journal of Molecular Sciences: Molecular Interactions and Mechanisms of COVID-19 Inhibition. ... Special Issue in International Journal of Molecular Sciences: Molecular Interactions and Mechanisms of COVID-19 Inhibition 2.0 ...
Enterobactin Deficiency in a Coliform Mastitis Isolate Decreases Its Fitness in a Murine Model: A Preliminary Host-Pathogen...
A Preliminary Host-Pathogen Interaction Study. Frontiers in Veterinary Science. 2020 Nov 9;7:576583. doi: 10.3389/fvets. ... A Preliminary Host-Pathogen Interaction Study. / Vander Elst, Niels; Breyne, Koen; Steenbrugge, Jonas et al. ... A Preliminary Host-Pathogen Interaction Study. Niels Vander Elst, Koen Breyne, Jonas Steenbrugge, Amanda Jane Gibson, David ... A Preliminary Host-Pathogen Interaction Study. In: Frontiers in Veterinary Science. 2020 ; Vol. 7. ...
How to Live with the Enemy: Understanding Tolerance to Parasites | PLOS Biology
1 Luonnontieteet - Doria
FEMS Expert: Dr Peter Sebo - FEMS
Host-bacterial pathogen interactions. • Bacterial protein toxins. • Molecular and cellular microbiology. • Immunology. • ... member of EAM and EMBO; guest editor for Pathogens and Disease Peter Sebo specializes in the RTX family of toxins produced by ... Peter Sebo guest edited the 2016 Bacterial Toxins Thematic Issue published in Pathogens and Disease. ... Head, Laboratory of Molecular Biology of Bacterial Pathogens. Cell and Molecular Microbiology Division ...
Universit de Gen ve, Conf rences de Chimie
Bacterial Pneumonia: Practice Essentials, Background, Pathophysiology
Pathogen-host interactions in Pseudomonas aeruginosa pneumonia. Am J Respir Crit Care Med. 2005 Jun 1. 171(11):1209-23. [QxMD ... Host resistance. Deficits in various host defenses and an inability to mount an appropriate acute inflammatory response can ... Although pneumonia may be caused by myriad pathogens, a limited number of agents are responsible for most cases, [3, 23, 24, 25 ... Insights into the interaction between influenza virus and pneumococcus. Clin Microbiol Rev. 2006 Jul. 19(3):571-82. [QxMD ...
Her research interests lie in host-pathogen interactions in intestinal biology. She has completed rotations in the labs of Dr. ... Read Pukkila-Worleys lab studying host-pathogen interactions in the model Caenorhabditis elegans. ... Pazours lab, where he worked to devise a strategy to reveal unfounded IFT-IFT20-related-protein interactions significant for ... he conducted research at Curry College where he explored the metabolic interactions, inhibition/induction of specific signal ...
January 2014 | CDC Online Newsroom | CDC
Joint Research Unit "Interactions Hosts-Pathogens" (INRA/ENVT). [email protected] ...
Indian Institute of Technology Kharagpur
Chin-Cheng Scotty Yang | Department of Entomology | Virginia Tech
Insect-microbe (pathogen) interactions. *Ecology and evolution of host-pathogen arms race ... pathogen interactions using ants/urban (or invasive) pests and their associated microbes/pathogens as model systems. Approaches ... The Yang Lab is focused on characterization of various insect-microbial interactions (including pathogens) through diverse ... Yangs current research interests include: 1) ecology and co-evolutionary history of insect-microbe (pathogen) interactions; 2 ...
Contribution of viral Bcl2 transmembrane domains to host-pathogen protein-protein interactions. (Poster). SEV-GVN 2019: XV ... Martinez-Gil L.; Garcia-Murria M.J.; Andreu-Fernandez V.; Orzaez M.; Mingarro I. (2017). Transmembrane interactions in ... transmembrane domain interact with host Bcl2 proteins to control cellular apoptosis. Nature Communications, 11(6056) . ISSN: ... Identification of transmembrane domain dependent protein-protein interactions. (Poster). VI Congreso Nacional de la Sociedad ...
BacterialMechanismsNCBIProtein InteractionsMediateDefensePathogenesisProteinsSystems biologyBacteriaDetectionInnateInfectionIncluding structuralReplicationAssayGlycanStructuresTumorigenesisValidated by experimentalMicroenvironmentMolecularAbstractPriorityToxinsResearchersPredictiveImmuneExperimentalCellsModelResponsesStudyImportantCancer2019Center
- We specifically explore their suitability for dynamic in vitro bioimaging of interactions between bacterial pathogens and host cells, and further demonstrate the facile surface functionalization of the amorphous silica layer with antibodies for selective cell targeting. (rsc.org)
- This topic aims to understand cellular and molecular mechanisms of immune-mediated collateral damage caused in the process of pathogen elimination. (umcutrecht.nl)
- Insight into the mechanisms and context of host-pathogen interactions can be gained by applying computational methods to a broad range of experimental, observational, and secondary data sources. (nih.gov)
- CIT): National Library of Medicine Informatics Lecture Series Insight into the mechanisms and context of host-pathogen interactions can be gained by applying computational methods to a broad range of experimental, observational, and secondary data sources. (nih.gov)
- However, the molecular mechanisms of exactly how they contribute to host tumorigenesis are still unknown. (nih.gov)
- The research findings of such projects should have the potential to be applicable or relevant to a variety of pathogenic organisms, which may help to identify common molecular mechanisms that cause persistent and recurrent infections and should lead to a better understanding of the biological, biochemical and biophysical processes of host-pathogen interaction or of the initiation and progression of infectious diseases in humans. (nih.gov)
- However, the molecular mechanisms how they trigger cancer in the host is generally unknown/incomplete. (nih.gov)
- Detection of host-pathogen interactions (HPIs) and mapping the re-wired HPI network - along with its structural details - is critical for in-depth understanding of the underlying pathogenesis mechanisms of infections, pathogen-triggered cancers, and developing efficient therapeutics. (nih.gov)
- Our results shed light on the molecular mechanisms of resistance to apoptosis, immune evasion and loss of cell junctions that are seen in H. pylori-infected host cells. (nih.gov)
- This topic reaches a new era towards the study of host-pathogen interactions mechanisms at the tissue scale. (archives-ouvertes.fr)
- Host-pathogen interactions (HPIs) affect and involve multiple mechanisms in both the pathogen and the host. (tau.ac.il)
- Pathogen interactions disrupt homeostasis in host cells, with their toxins interfering with host mechanisms, resulting in infections, diseases, and disorders, extending from AIDS and COVID-19, to cancer. (tau.ac.il)
- Mechanisms of virulence and host response differ from TB, but are poorly understood. (qub.ac.uk)
- The molecular mechanisms underlying such equilibrium remains poorly understood and most likely relies on the dynamic interactions between viral RNAs and host and viral proteins as well as on RNA modifications. (taylorandfrancis.com)
- The Phix module stores all possible gene expression experiment records related to a list of priority pathogens and relevant host-pathogen interactions from NCBI GEO and EBI ArrayExpress . (phidias.us)
- Although these experiments can identify the host factors that directly or indirectly facilitate or inhibit the replication of a virus in a host cell, they do not elucidate how these genes are organized into the biological pathways that mediate host-virus interactions. (nih.gov)
- It is known that glycans play a key role in infections and other diseases of the oral mucosa because they mediate interactions between hosts and oral pathogens as well as among oral pathogens. (nih.gov)
- For her Ph.D., she studied complement since it is the first line of defense against invading bloodborne pathogens. (nih.gov)
- Although a systems biology approach could be used to investigate complex biological events, such as cell behavior or microbial communities, the focus of this contract is only on molecular cellular events of the interaction of the pathogen and the host, such as those involved in the biological, biochemical and biophysical processes of microbial organisms or in pathogenesis and disease progression in humans. (nih.gov)
- In conclusion, HPIs can help us unravel which human pathways are targeted by pathogenic proteins and how they contribute to pathogenesis of infections and pathogen-triggered cancer. (nih.gov)
- A better understanding of these virus/host interactions is relevant not only for identifying therapeutic targets and pathogenesis determinants but also for shedding light on the basic principles of RNA molecular biology. (taylorandfrancis.com)
- With the aim to better understand flavivirus pathogenesis and to identify new promising antiviral targets, his research team focuses on the identification of flavivirus/host interactions engaged in the viral hijacking of cellular machineries important for the infection. (taylorandfrancis.com)
- Interface similarity allows pathogen proteins to compete with host counterparts to bind to a target protein, rewire physiological signaling, and result in persistent infections, as well as cancer. (nih.gov)
- Pathogens interact with the host mainly through proteins. (nih.gov)
- This similarity in interfaces permits pathogenic protein to compete with host proteins to bind to a target protein, alter physiological signaling and cause persistent infections, as well as cancer. (nih.gov)
- We found that its proteins interfere with the functioning of host apoptosis pathway, cytokine and chemokine pathways, and also cell-cell adhesions. (nih.gov)
- These pathogens have evolved to produce the optimal concentration of viral proteins which drive their life cycle, notably by hijacking the post-translational machinery of the infected cell. (taylorandfrancis.com)
- Such regulation is mediated at multiple levels, such as RNA modification, transport, stability and/or translation, through interactions between viral RNAs and host RNA-binding proteins. (taylorandfrancis.com)
- The Division of Microbiology and Infectious Diseases, NIAID has a requirement to establish multi-disciplinary centers that focus on understanding at a molecular level the host-pathogen interaction using a systems biology approach. (nih.gov)
- Specifically, we have exploited the interaction of amphiphilic pathogen biomarkers such as lipopolysaccharides (LPS) from Gram-negative bacteria and lipoteichoic acids (LTA) from Gram-positive bacteria with host lipoprotein carriers in blood, in order to develop two tailored assays - lipoprotein capture and membrane insertion - for their direct detection. (nature.com)
- The host responds to the presence of dividing bacteria by releasing numerous extra- and intra-cellular signaling molecules. (nih.gov)
- In this manuscript, we have developed and clinically validated a novel method for the direct detection of amphiphilic pathogen biomarkers indicative of bacteremia, directly in aqueous blood, by mimicking innate immune recognition. (nature.com)
- The "Porkchip" project is working on developing a system for rapid, parallel detection, anywhere on the food chain, of porcine pathogens that may have a financial and health impact. (fu-berlin.de)
- and oral pathogen-host interactions through oral innate, mucosal and adaptive immune responses. (nih.gov)
- predict, identify and quantify changes in expression of the transcriptome or proteome of both the host and the microbial organism in a human macrophage culture model during various stages of persistent and recurrent infection of the host. (nih.gov)
- Transcriptional studies, using RNA-seq to characterize the infection-regulated transcriptome of diverse insects, are crucial for additional progress in understanding the ecology and evolution of the full complexity of the host response. (harvard.edu)
- This event aims to promote interaction and collaboration among researchers in the area and provide opportunities for learning about cutting-edge tools, approaches, and resources to advance their research in the areas of infection and inflammation. (und.edu)
- Firstly, we showed that expression of lipocalin 2, a protein produced by the host that is able to both bind and deplete enterobactin, is increased upon E. coli infection in the cow's mastitic mammary gland. (aber.ac.uk)
- This viral infection elicits responses from the host that rapidly change the microenvironment of the upper respiratory tract, Eustachian tube, and middle ear. (nih.gov)
- HPI data including structural details is far from complete and experimental characterization of the large-scale inter-species interactions is challenging. (nih.gov)
- In the first study, he is focused on inferring host subnetworks that are involved in viral replication from genome-wide loss-of-function experiments. (nih.gov)
- Taken together, these results demonstrate the significance of biochemistry in both our understanding of host-pathogen biology, and development of assay methodology, as well as demonstrate a potential new approach for the rapid, sensitive and accurate diagnosis of bacteremia at the point of need. (nature.com)
- More specifically, the structure of glycan moieties on glycoproteins, glycolipids, and glycoconjugates of infectious pathogens plays an important role in determining the balance between health and disease such as AIDS and its persisting oral manifestations. (nih.gov)
- Elucidating glycan structure, their abundance, and their distribution on glycoproteins, glycolipids, and glycoconjugates of infectious pathogens has the potential to provide us with new strategies for identification of a new class of biomarkers and therapeutic targets in the future. (nih.gov)
- Fungal glycan interactions with epithelial cells in allergic airway disease. (nih.gov)
- Studies of the three-dimensional (3D) structures of host-pathogen complexes aim to understand how pathogens interact with their hosts. (tau.ac.il)
- Despite growing recognition of the importance of glycans for oral health and disease, it is not well understood how different structures of glycans in oral pathogens, such as stereoisomers, chain bifurcations and modifications including phosphorylation, methylation, sulfation, and acetylation influence their ability to cause and/or modulate oral infections and diseases. (nih.gov)
- We applied our interface-based approach to H. pylori, dominant species in gastric microbiome that greatly increases gastric cancer risk in order to understand how they modulate host immunity and lead to tumorigenesis. (nih.gov)
Validated by experimental1
- It is expected that integrated data sets will be used to build mathematical models of host-pathogen interactions that can be validated by experimental approaches, explaining the molecular basis of clinical manifestations of infectious diseases, including severity and response to treatment and vaccines. (nih.gov)
- This review summarises how this technology recapitulates the architecture, the mechanical stimulation and the interface of a tissue and how this particular microenvironment is critical to study host-pathogen interactions. (archives-ouvertes.fr)
- The primary goal of the activities carried out under this contract will be to investigate and identify the metabolic, regulatory, signaling, and other biological pathways generated by host-pathogen molecular interactions to help explain and predict clinical manifestations of infectious diseases, host responses, disease progression, and outcomes. (nih.gov)
- This contract will NOT support studies that focus exclusively on the molecular interaction networks of the microbe with no consideration of those in the host cells, and vice versa. (nih.gov)
- This research training group handles possible interactions between pathogens and their hosts at the molecular level. (fu-berlin.de)
- Phix also provides search for specific gene profiles from studies involving one or all of our priority pathogens from GEO or ArrayExpress. (phidias.us)
- Third, host-microbe interactions show priority for efforts directed at bioterrorism, great variability related to host-microbial research advances in infectious diseases of the genetics and host-microbial cross-talk. (nih.gov)
- Researchers supported by NIAID are conducting studies on how microbes colonize the host, which toxins microbes produce, and how microbes avoid or overcome an attack by the host's immune defenses. (nih.gov)
- NIAID researchers also are exploring host factors-the traits that may influence an individual's susceptibility and response to disease. (nih.gov)
- Dr. Craven will discuss his work in three studies that involve developing and applying predictive methods in order to characterize host-pathogen interactions. (nih.gov)
- As more genomes and transcriptomes across insects are sequenced, it is becoming clear that duplications and losses of immune genes are also a likely consequence of host-pathogen interactions. (harvard.edu)
- Host-targeted interventions that harness a person's immune system, rather than the microbes themselves, are being explored as alternative treatments to conventional antimicrobial drugs. (nih.gov)
- Because complex interactions between host and pathogen are likely to be significantly influenced by experimental conditions, any results obtained in animal models should be confirmed for accuracy using human materials. (nih.gov)
- Inhaled fungi contact airway epithelial cells as an early event, and this host:fungal interaction can shape the eventual immunological outcome. (nih.gov)
- Using microarray analysis and a suitable model system, host and pathogen gene expression could be followed throughout the entire disease process. (nih.gov)
- The Symposium will bring together experts investigating both microbial infectious agents and host responses to those infectious agents. (und.edu)
- In the second study, he is applying machine-learning methods to understand how variation in the genome of HSV-1 influences multiple ocular disease phenotypes in a host. (nih.gov)
- In JG, Foulke-Abel J , Clarke E, Kovbasnjuk O. Human Colonoid Monolayers to Study Interactions Between Pathogens, Commensals, and Host Intestinal Epithelium. (hopkinsmedicine.org)
- Comprehensive understandings on the life logic of SARS-CoV-2 and the interaction of the virus with hosts are fundamentally important in the fight against SARS-CoV-2. (nih.gov)
- There is a strong correlation of some pathogens with various cancer types, such as Helicobacter pylori with gastric cancer. (nih.gov)
- The Center for Biomedical Research Excellence (CoBRE) for Host-Pathogen Interactions is inviting UND faculty, staff, and graduate and undergraduate students to attend the annual Host-Pathogen CoBRE Symposium to be held at the UND School of Medicine & Health Sciences on Tuesday, Sept. 17, 2019. (und.edu)
- Conference presentations: Cold Spring Harbor Meeting on Host Pathogen Interactions, Sanger Center, Hinxton (2004) Poster. (uea.ac.uk)