Host-Pathogen Interactions

Plant Diseases

Virulence

Host-pathogen interaction

Wall-associated kinase

Mitochondrial outer membrane permeabilization

Anne Moscona

Human coronavirus HKU1

Arturo Casadevall

Hologenomics

Adam Bogdanove

Herbivore adaptations to plant defense

Antigenic escape

Multiomics

Host adaptation

PHI-base

Siderocalin

Alex K. Shalek

Gene-for-gene relationship

Lyme disease

Dorothy Yeboah-Manu

Dictyostelium discoideum

Fusarium solani

Steinernema carpocapsae

Debby Bogaert

Rothamsted Research

Bacillus cereus

Vesicle (biology and chemistry)

Digestion

Secretion

Zebrafish

List of people associated with Utrecht University

Cell adhesion

Black yeast

Melon necrotic spot virus

Coronavirus nucleocapsid protein

Metabolism

YqaJ protein domain

Interferon

Tick infestation

Diseases of poverty

Leishmania braziliensis

Viroporin

Rhodnius prolixus

Lutzomyia longipalpis

Toll-like receptor 6

Bumblebee

Brucella suis

Ustilaginomycotina

Ubiquitin-like protein

Xanthoferrin

Cranberry

Antimicrobial

Lernaeocera branchialis

Sphaceloma perseae

Hamiltosporidium

Chytridiomycota

Pattern recognition receptor

Biofouling

Bacteroides thetaiotaomicron

Environmental DNA

Theresa Koehler

Bacterial1

• We specifically explore their suitability for dynamic in vitro bioimaging of interactions between bacterial pathogens and host cells, and further demonstrate the facile surface functionalization of the amorphous silica layer with antibodies for selective cell targeting. (rsc.org)

Mechanisms13

• This topic aims to understand cellular and molecular mechanisms of immune-mediated collateral damage caused in the process of pathogen elimination. (umcutrecht.nl)
• Insight into the mechanisms and context of host-pathogen interactions can be gained by applying computational methods to a broad range of experimental, observational, and secondary data sources. (nih.gov)
• CIT): National Library of Medicine Informatics Lecture Series Insight into the mechanisms and context of host-pathogen interactions can be gained by applying computational methods to a broad range of experimental, observational, and secondary data sources. (nih.gov)
• However, the molecular mechanisms of exactly how they contribute to host tumorigenesis are still unknown. (nih.gov)
• The research findings of such projects should have the potential to be applicable or relevant to a variety of pathogenic organisms, which may help to identify common molecular mechanisms that cause persistent and recurrent infections and should lead to a better understanding of the biological, biochemical and biophysical processes of host-pathogen interaction or of the initiation and progression of infectious diseases in humans. (nih.gov)
• However, the molecular mechanisms how they trigger cancer in the host is generally unknown/incomplete. (nih.gov)
• Detection of host-pathogen interactions (HPIs) and mapping the re-wired HPI network - along with its structural details - is critical for in-depth understanding of the underlying pathogenesis mechanisms of infections, pathogen-triggered cancers, and developing efficient therapeutics. (nih.gov)
• Our results shed light on the molecular mechanisms of resistance to apoptosis, immune evasion and loss of cell junctions that are seen in H. pylori-infected host cells. (nih.gov)
• This topic reaches a new era towards the study of host-pathogen interactions mechanisms at the tissue scale. (archives-ouvertes.fr)
• Host-pathogen interactions (HPIs) affect and involve multiple mechanisms in both the pathogen and the host. (tau.ac.il)
• Pathogen interactions disrupt homeostasis in host cells, with their toxins interfering with host mechanisms, resulting in infections, diseases, and disorders, extending from AIDS and COVID-19, to cancer. (tau.ac.il)
• Mechanisms of virulence and host response differ from TB, but are poorly understood. (qub.ac.uk)
• The molecular mechanisms underlying such equilibrium remains poorly understood and most likely relies on the dynamic interactions between viral RNAs and host and viral proteins as well as on RNA modifications. (taylorandfrancis.com)

NCBI1

• The Phix module stores all possible gene expression experiment records related to a list of priority pathogens and relevant host-pathogen interactions from NCBI GEO and EBI ArrayExpress . (phidias.us)

Protein Interactions2

• Elucidating the Stoichiometries of Host-Pathogen Protein Interactions with Mass Photometry. (bvsalud.org)
• This review describes the state-of-the-art in protein-protein interactions (PPIs) between the host and pathogens from the structural standpoint. (tau.ac.il)

Mediate2

• Although these experiments can identify the host factors that directly or indirectly facilitate or inhibit the replication of a virus in a host cell, they do not elucidate how these genes are organized into the biological pathways that mediate host-virus interactions. (nih.gov)
• It is known that glycans play a key role in infections and other diseases of the oral mucosa because they mediate interactions between hosts and oral pathogens as well as among oral pathogens. (nih.gov)

Defense1

• For her Ph.D., she studied complement since it is the first line of defense against invading bloodborne pathogens. (nih.gov)

Pathogenesis4

• Although a systems biology approach could be used to investigate complex biological events, such as cell behavior or microbial communities, the focus of this contract is only on molecular cellular events of the interaction of the pathogen and the host, such as those involved in the biological, biochemical and biophysical processes of microbial organisms or in pathogenesis and disease progression in humans. (nih.gov)
• In conclusion, HPIs can help us unravel which human pathways are targeted by pathogenic proteins and how they contribute to pathogenesis of infections and pathogen-triggered cancer. (nih.gov)
• A better understanding of these virus/host interactions is relevant not only for identifying therapeutic targets and pathogenesis determinants but also for shedding light on the basic principles of RNA molecular biology. (taylorandfrancis.com)
• With the aim to better understand flavivirus pathogenesis and to identify new promising antiviral targets, his research team focuses on the identification of flavivirus/host interactions engaged in the viral hijacking of cellular machineries important for the infection. (taylorandfrancis.com)

Proteins6

• Interface similarity allows pathogen proteins to compete with host counterparts to bind to a target protein, rewire physiological signaling, and result in persistent infections, as well as cancer. (nih.gov)
• Pathogens interact with the host mainly through proteins. (nih.gov)
• This similarity in interfaces permits pathogenic protein to compete with host proteins to bind to a target protein, alter physiological signaling and cause persistent infections, as well as cancer. (nih.gov)
• We found that its proteins interfere with the functioning of host apoptosis pathway, cytokine and chemokine pathways, and also cell-cell adhesions. (nih.gov)
• These pathogens have evolved to produce the optimal concentration of viral proteins which drive their life cycle, notably by hijacking the post-translational machinery of the infected cell. (taylorandfrancis.com)
• Such regulation is mediated at multiple levels, such as RNA modification, transport, stability and/or translation, through interactions between viral RNAs and host RNA-binding proteins. (taylorandfrancis.com)

Systems biology1

• The Division of Microbiology and Infectious Diseases, NIAID has a requirement to establish multi-disciplinary centers that focus on understanding at a molecular level the host-pathogen interaction using a systems biology approach. (nih.gov)

Bacteria2

• Specifically, we have exploited the interaction of amphiphilic pathogen biomarkers such as lipopolysaccharides (LPS) from Gram-negative bacteria and lipoteichoic acids (LTA) from Gram-positive bacteria with host lipoprotein carriers in blood, in order to develop two tailored assays - lipoprotein capture and membrane insertion - for their direct detection. (nature.com)
• The host responds to the presence of dividing bacteria by releasing numerous extra- and intra-cellular signaling molecules. (nih.gov)

Detection2

• In this manuscript, we have developed and clinically validated a novel method for the direct detection of amphiphilic pathogen biomarkers indicative of bacteremia, directly in aqueous blood, by mimicking innate immune recognition. (nature.com)
• The "Porkchip" project is working on developing a system for rapid, parallel detection, anywhere on the food chain, of porcine pathogens that may have a financial and health impact. (fu-berlin.de)

Innate1

• and oral pathogen-host interactions through oral innate, mucosal and adaptive immune responses. (nih.gov)

Infection5

• predict, identify and quantify changes in expression of the transcriptome or proteome of both the host and the microbial organism in a human macrophage culture model during various stages of persistent and recurrent infection of the host. (nih.gov)
• Transcriptional studies, using RNA-seq to characterize the infection-regulated transcriptome of diverse insects, are crucial for additional progress in understanding the ecology and evolution of the full complexity of the host response. (harvard.edu)
• This event aims to promote interaction and collaboration among researchers in the area and provide opportunities for learning about cutting-edge tools, approaches, and resources to advance their research in the areas of infection and inflammation. (und.edu)
• Firstly, we showed that expression of lipocalin 2, a protein produced by the host that is able to both bind and deplete enterobactin, is increased upon E. coli infection in the cow's mastitic mammary gland. (aber.ac.uk)
• This viral infection elicits responses from the host that rapidly change the microenvironment of the upper respiratory tract, Eustachian tube, and middle ear. (nih.gov)

Including structural1

• HPI data including structural details is far from complete and experimental characterization of the large-scale inter-species interactions is challenging. (nih.gov)

Replication1

• In the first study, he is focused on inferring host subnetworks that are involved in viral replication from genome-wide loss-of-function experiments. (nih.gov)

Assay1

• Taken together, these results demonstrate the significance of biochemistry in both our understanding of host-pathogen biology, and development of assay methodology, as well as demonstrate a potential new approach for the rapid, sensitive and accurate diagnosis of bacteremia at the point of need. (nature.com)

Glycan3

• More specifically, the structure of glycan moieties on glycoproteins, glycolipids, and glycoconjugates of infectious pathogens plays an important role in determining the balance between health and disease such as AIDS and its persisting oral manifestations. (nih.gov)
• Elucidating glycan structure, their abundance, and their distribution on glycoproteins, glycolipids, and glycoconjugates of infectious pathogens has the potential to provide us with new strategies for identification of a new class of biomarkers and therapeutic targets in the future. (nih.gov)
• Fungal glycan interactions with epithelial cells in allergic airway disease. (nih.gov)

Structures2

• Studies of the three-dimensional (3D) structures of host-pathogen complexes aim to understand how pathogens interact with their hosts. (tau.ac.il)
• Despite growing recognition of the importance of glycans for oral health and disease, it is not well understood how different structures of glycans in oral pathogens, such as stereoisomers, chain bifurcations and modifications including phosphorylation, methylation, sulfation, and acetylation influence their ability to cause and/or modulate oral infections and diseases. (nih.gov)

Tumorigenesis1

• We applied our interface-based approach to H. pylori, dominant species in gastric microbiome that greatly increases gastric cancer risk in order to understand how they modulate host immunity and lead to tumorigenesis. (nih.gov)

Validated by experimental1

• It is expected that integrated data sets will be used to build mathematical models of host-pathogen interactions that can be validated by experimental approaches, explaining the molecular basis of clinical manifestations of infectious diseases, including severity and response to treatment and vaccines. (nih.gov)

Microenvironment1

• This review summarises how this technology recapitulates the architecture, the mechanical stimulation and the interface of a tissue and how this particular microenvironment is critical to study host-pathogen interactions. (archives-ouvertes.fr)

Molecular3

• The primary goal of the activities carried out under this contract will be to investigate and identify the metabolic, regulatory, signaling, and other biological pathways generated by host-pathogen molecular interactions to help explain and predict clinical manifestations of infectious diseases, host responses, disease progression, and outcomes. (nih.gov)
• This contract will NOT support studies that focus exclusively on the molecular interaction networks of the microbe with no consideration of those in the host cells, and vice versa. (nih.gov)
• This research training group handles possible interactions between pathogens and their hosts at the molecular level. (fu-berlin.de)

Abstract1

• Researchers investigating host-pathogen questions are encouraged to submit an abstract for poster presentation (to be held in the afternoon on September 17) to Shannon Bupp ( [email protected] ) by Wednesday, July 31. (und.edu)

Priority2

• Phix also provides search for specific gene profiles from studies involving one or all of our priority pathogens from GEO or ArrayExpress. (phidias.us)
• Third, host-microbe interactions show priority for efforts directed at bioterrorism, great variability related to host-microbial research advances in infectious diseases of the genetics and host-microbial cross-talk. (nih.gov)

Toxins1

• Researchers supported by NIAID are conducting studies on how microbes colonize the host, which toxins microbes produce, and how microbes avoid or overcome an attack by the host's immune defenses. (nih.gov)

Researchers1

• NIAID researchers also are exploring host factors-the traits that may influence an individual's susceptibility and response to disease. (nih.gov)

Predictive1

• Dr. Craven will discuss his work in three studies that involve developing and applying predictive methods in order to characterize host-pathogen interactions. (nih.gov)

Immune2

• As more genomes and transcriptomes across insects are sequenced, it is becoming clear that duplications and losses of immune genes are also a likely consequence of host-pathogen interactions. (harvard.edu)
• Host-targeted interventions that harness a person's immune system, rather than the microbes themselves, are being explored as alternative treatments to conventional antimicrobial drugs. (nih.gov)

Experimental1

• Because complex interactions between host and pathogen are likely to be significantly influenced by experimental conditions, any results obtained in animal models should be confirmed for accuracy using human materials. (nih.gov)

Cells1

• Inhaled fungi contact airway epithelial cells as an early event, and this host:fungal interaction can shape the eventual immunological outcome. (nih.gov)

Model1

• Using microarray analysis and a suitable model system, host and pathogen gene expression could be followed throughout the entire disease process. (nih.gov)

Responses1

• The Symposium will bring together experts investigating both microbial infectious agents and host responses to those infectious agents. (und.edu)

Study2

• In the second study, he is applying machine-learning methods to understand how variation in the genome of HSV-1 influences multiple ocular disease phenotypes in a host. (nih.gov)
• In JG, Foulke-Abel J , Clarke E, Kovbasnjuk O. Human Colonoid Monolayers to Study Interactions Between Pathogens, Commensals, and Host Intestinal Epithelium. (hopkinsmedicine.org)

Important1

• Comprehensive understandings on the life logic of SARS-CoV-2 and the interaction of the virus with hosts are fundamentally important in the fight against SARS-CoV-2. (nih.gov)

Cancer1

• There is a strong correlation of some pathogens with various cancer types, such as Helicobacter pylori with gastric cancer. (nih.gov)

20191

• The Center for Biomedical Research Excellence (CoBRE) for Host-Pathogen Interactions is inviting UND faculty, staff, and graduate and undergraduate students to attend the annual Host-Pathogen CoBRE Symposium to be held at the UND School of Medicine & Health Sciences on Tuesday, Sept. 17, 2019. (und.edu)

Center1

• Conference presentations: Cold Spring Harbor Meeting on Host Pathogen Interactions, Sanger Center, Hinxton (2004) Poster. (uea.ac.uk)