Pluto
Religion and Sex
Paraphilias
Homophobia
Gender Identity
Social Problems
Bisexuality
Social Stigma
Attitude
Rapid death of adoptively transferred T cells in acquired immunodeficiency syndrome. (1/1954)
Human immunodeficiency virus (HIV)-specific cytotoxic T lymphocytes (CTL) probably play the major role in controlling HIV replication. However, the value of adoptive transfer of HIV-specific CTL expanded in vitro to HIV+ patients has been limited: this contrasts with the success of CTL therapy in treating or preventing Epstein-Barr virus and cytomegalovirus disease after bone marrow transplantation (BMT). We investigated the fate of expanded HIV-specific CTL clones in vivo following adoptive transfer to a patient with acquired immunodeficiency syndrome (AIDS). Two autologous CTL clones specific for HIV Gag and Pol were expanded to large numbers (>10(9)) in vitro and infused into an HIV-infected patient whose viral load was rising despite antiretroviral therapy. The fate of one clone was monitored by staining peripheral blood mononuclear cells (PBMCs) with T-cell receptor-specific tetrameric major histocompatibility complex (MHC)-peptide complexes. Although the CTL transfer was well tolerated, there were no significant changes in CD4 and CD8 lymphocyte counts and virus load. By tracking an infused clone using soluble MHC-peptide complexes, we show that cells bearing the Gag-specific T-cell receptors were rapidly eliminated within hours of infusion through apoptosis. Thus, the failure of adoptively transferred HIV-specific CTL to reduce virus load in AIDS may be due to rapid apoptosis of the infused cells, triggered by a number of potential mechanisms. Further trials of adoptive transfer of CTL should take into account the susceptibility of infused cells to in vivo apoptosis. (+info)Changing epidemiology of hepatitis A in the 1990s in Sydney, Australia. (2/1954)
Surveillance of hepatitis A in residents of Eastern Sydney Health Area identified substantial epidemics in homosexual males in 1991-2 with a peak rate of 520 per 100,000 recorded in males aged 25-29 years, and again in 1995-6, with a peak rate of 405 per 100,000 per year in males aged 30-34 years. During 1994-5 an epidemic was detected among disadvantaged youth associated with injecting drug use; peak rates of 200 per 100,000 per year were reported in males aged 25-29 years and of 64 per 100,000 per year among females aged 20-24 years. The epidemiology of hepatitis A in these inner suburbs of Sydney is characterized by very few childhood cases and recurrent epidemics among homosexual men. Identified risk groups need to be targeted with appropriate messages regarding the importance of hygiene and vaccination in preventing hepatitis A. However, poor access to health services among disadvantaged youth and a constant influx of young homosexual males into these inner suburbs present major challenges to hepatitis A control. (+info)Coalescent estimates of HIV-1 generation time in vivo. (3/1954)
The generation time of HIV Type 1 (HIV-1) in vivo has previously been estimated using a mathematical model of viral dynamics and was found to be on the order of one to two days per generation. Here, we describe a new method based on coalescence theory that allows the estimate of generation times to be derived by using nucleotide sequence data and a reconstructed genealogy of sequences obtained over time. The method is applied to sequences obtained from a long-term nonprogressing individual at five sampling occasions. The estimate of viral generation time using the coalescent method is 1.2 days per generation and is close to that obtained by mathematical modeling (1.8 days per generation), thus strengthening confidence in estimates of a short viral generation time. Apart from the estimation of relevant parameters relating to viral dynamics, coalescent modeling also allows us to simulate the evolutionary behavior of samples of sequences obtained over time. (+info)Oral examination: a screening tool for HIV infection? (4/1954)
OBJECTIVE: To estimate the predictive values for HIV infection of diagnosis of oral manifestations of the infection. METHOD: Prevalence of oral manifestations was compared in cross sectional blinded clinical examinations of homosexual men attending a genitourinary medicine clinic. Data were extrapolated to populations in England and Wales based on estimates of the prevalence of HIV infection. RESULTS: Data were analysed for 572 HIV infected and non-infected men (312 and 260 respectively). Positive predictive values for erythematous candidiasis, hairy leucoplakia and pseudomembranous candidiasis were greater than 0.96 at the genitourinary medicine clinic and are estimated to be greater than 0.72 among homosexual men in London. CONCLUSIONS: Clinical diagnoses of mucosal lesions alone are poor predictors of HIV infection but are useful when used in conjunction with a social history to establish if there are risk factors for infection. (+info)Sexual transmission and prevention of the hepatitis viruses A-E and G. (5/1954)
OBJECTIVES: To assess current knowledge about the potential for sexual transmission of the hepatitis viruses A-E and G and how to prevent any such transmission. METHOD: A search of published literature identified through Medline 1966-June 1998 (Ovid v 3.0), the Cochrane Library and reference lists taken from each article obtained. Textword and MeSH searches for hepatitis A, B, C, D, E, G, delta, GB virus, GBV-C were linked to searches under the textword terms sex$, vaccine$, prevent$, and MeSH subheadings, epidemiology, transmission, prevention, and control. CONCLUSIONS: There is evidence for heterosexual transmission of hepatitis B, C, D, and G and homosexual transmission of hepatitis A-D and G. Condoms are an effective method for preventing transmission by penetrative vaginal or anal sex although spread of types A and B are linked also to oro-anal sex. Hepatitis types A and B can be prevented by pre- and post-exposure active or passive immunisation. There is still some uncertainty about appropriate target groups for pre-exposure vaccination, particularly against hepatitis A. (+info)Partner notification for gonorrhoea: a comparative study with a provincial and a metropolitan UK clinic. (6/1954)
OBJECTIVE: To compare partner notification practice and outcomes at a provincial and a metropolitan clinic. DESIGN: Prospective study, following standardisation of partner notification policy. SETTINGS: Sheffield Department of Genitourinary Medicine, Royal Hallamshire Hospital and Jefferiss Wing Centre for Sexual Health, St Mary's Hospital, London. SUBJECTS: Consecutive patients with culture positive gonorrhoea between October 1994 and March 1996 who were interviewed by a health adviser. RESULTS: In Sheffield, 235 cases reported 659 outstanding contacts, of whom 129 (20%) were subsequently screened, and 65 (50%) had gonorrhoea. At St Mary's 510 cases reported 2176 outstanding contacts, of whom 98 (5%) were known to have been screened, and 53 (54%) had gonorrhoea. Patient or provider referral agreements appeared more productive in Sheffield, where 60% resulted in contact attendance, compared with 13% at St Mary's. Provider referral was used more frequently in Sheffield, for 44% of referrals, compared with 1% at St Mary's. Multivariate analysis showed that partner notification was less effective for casual and short term (< 7 days) partnerships in both centres, and for homosexual men at St Mary's. CONCLUSION: Partner notification outcomes were better in the provincial setting where contact attendance could be recorded more reliably and provider referral was used more extensively. The high proportion of contacts who remained untraced in both settings indicates the need for complementary screening and prevention initiatives. (+info)Male homosexuality: absence of linkage to microsatellite markers at Xq28. (7/1954)
Several lines of evidence have implicated genetic factors in homosexuality. The most compelling observation has been the report of genetic linkage of male homosexuality to microsatellite markers on the X chromosome. This observation warranted further study and confirmation. Sharing of alleles at position Xq28 was studied in 52 gay male sibling pairs from Canadian families. Four markers at Xq28 were analyzed (DXS1113, BGN, Factor 8, and DXS1108). Allele and haplotype sharing for these markers was not increased over expectation. These results do not support an X-linked gene underlying male homosexuality. (+info)Behavioural risk factors for HIV/AIDS in a low-HIV prevalence Muslim nation: Bangladesh. (8/1954)
A review of published and unpublished data indicates the prevalence of high-risk behaviours for HIV transmission in segments of the Bangladeshi population. These include casual unprotected sex, heterosexual as well as between males, prior to and after marriage. Intravenous drug use (IVDU) exists though illicit drugs are more commonly inhaled. There is a fear, however, that inhalers may turn to injecting drugs, as is common in neighbouring countries. The lack of public awareness of HIV/AIDS, and misconceptions about the disease, may contribute to continued high-risk behaviours by segments of the population and, thus, to the spread of HIV. Bangladesh's proximity to India and Myanmar (countries with high HIV endemicity and a rapidly growing number of cases) increases fears of an epidemic in Bangladesh. This proximity will only be a risk factor, however, if high-risk contacts occur between nationals of these countries. (+info)Medical definitions are often avoided in favor of more objective language when discussing personal characteristics or identities, such as sexual orientation. This is because sexual orientation is not considered a medical condition or disorder, but rather a natural part of human diversity. The American Psychological Association defines sexual orientation as "an enduring emotional, romantic, sexual, or affectional attraction to another person." It can be distinguished into different categories, including heterosexuality (attraction to individuals of the other gender), bisexuality (attraction to individuals of either gender), and homosexuality (attraction to individuals of the same gender).
It's important to note that a person's sexual orientation is not considered a choice or something that can be changed through willpower or therapy. It is a deeply ingrained aspect of a person's identity, and it is protected under laws and regulations in many countries as a fundamental human right.
Medical definitions are often provided by authoritative medical bodies such as the World Health Organization (WHO) or the American Psychiatric Association (APA). It's important to note that these organizations have evolved their understanding and classification of homosexuality over time.
According to the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5), produced by the APA, sexual orientation is not considered a mental disorder. The manual does not provide a definition or classification for 'homosexuality, male' as a medical condition.
The current understanding in the medical community is that homosexuality is a normal and natural variation of human sexual orientation. It is not considered a disorder or an illness. The World Health Organization (WHO) removed homosexuality from its list of mental disorders in 1990.
I'm sorry for any confusion, but "Pluto" is not a term used in medical definitions. It is the ninth planet from the Sun in our solar system, according to its discovery in 1930. However, in 2006, the International Astronomical Union (IAU) redefined the definition of a planet and Pluto did not meet all the criteria, so it's now classified as a "dwarf planet."
If you have any medical concerns or questions, I would be happy to help if you could provide more information!
I'm happy to help, but I think there might be a bit of confusion in your question. Religion and sex are two distinct concepts that don't have a medical definition when combined. However, I can provide you with some information about each one separately.
Religion: Religion is a set of beliefs, practices, rituals, and moral values that are shared by a community or group of individuals. It often involves a belief in a higher power or powers, and may include various traditions, ceremonies, and teachings.
Sex: Sex refers to the biological characteristics that define males and females. It is usually determined by an individual's anatomy, chromosomes, and reproductive organs. Sex can also refer to sexual activity, which involves the intimate contact between two or more individuals for the purpose of sexual pleasure, reproduction, or both.
If you have any specific questions about either religion or sex in a medical context, please let me know and I'll do my best to provide a helpful response!
Paraphilias are a category of mental disorders characterized by recurrent, intense, sexually arousing fantasies, sexual urges, or behaviors that involve unusual objects, activities, or situations and cause clinically significant distress or impairment in social, occupational, or other important areas of functioning. The fantasies, sexual urges, or behaviors may be directed toward children, non-consenting individuals, or causing physical harm to oneself or others. Some examples include voyeuristic disorder, exhibitionistic disorder, frotteuristic disorder, sexual masochism disorder, sexual sadism disorder, pedophilic disorder, fetishistic disorder, and transvestic disorder. It's important to note that these behaviors must be causing distress or impairment in order for it to be considered a disorder.
Female homosexuality, also known as lesbianism, is a romantic and/or sexual attraction or behavior between females. It is one of the forms of human sexual orientation, which also includes heterosexuality and bisexuality. Homosexual women, like gay men, can form committed relationships, have families, and live happy and fulfilling lives. It's important to note that homosexuality is not considered a mental illness or disorder by any major medical or psychological organization, including the American Psychiatric Association and the World Health Organization.
Homophobia is not a term that has a medical definition in the field of psychiatry or psychology. However, it is a commonly used term to describe an irrational fear, hatred, or prejudice against individuals who identify as LGBTQ+ (lesbian, gay, bisexual, transgender, queer, and other non-heterosexual identities). Homophobia can manifest in various ways, including negative attitudes, discriminatory behaviors, and violence towards LGBTQ+ individuals. It's essential to recognize and challenge homophobic beliefs and actions to promote inclusivity, respect, and equality for all individuals, regardless of their sexual orientation or gender identity.
Gender Identity is a deeply-held sense of being male, female, or something else and may not necessarily correspond to an individual's biological sex. It is a personal experience of gender that may include a person's sense of the role they should play in society, their self-image, expectations of how they should be treated by others, and their feelings about their bodies. This concept is a fundamental aspect of a person's self-concept and psychological well-being. It is separate from a person's sexual orientation.
The American Psychiatric Association states that "gender identity refers to a person’s internal sense of gender, or the feeling of being male, female, or something else." According to the World Health Organization (WHO), "gender identity refers to a person’s deeply-felt sense of being male, female or something else and may not necessarily correspond to an individual’s biological sex."
It's important to note that gender identity is a complex and nuanced concept, and it can change over time for some individuals. It's also distinct from sexual orientation, which refers to a person's emotional, romantic, or sexual attraction to other people.
Birth order is a term that refers to the sequence in which a person is born in their family, specifically in relation to their siblings. It is used in psychology and sociology to describe the various personality traits, behaviors, and developmental milestones that have been associated with being the firstborn, middle child, youngest child, or an only child.
For example, some studies suggest that firstborn children tend to be more responsible, achievement-oriented, and socially dominant than their younger siblings, while later-born children may be more easygoing, adventurous, and rebellious. However, it's important to note that these patterns are not universal and can be influenced by a variety of factors, including family size, spacing between siblings, gender, parenting style, and individual temperament.
Overall, birth order is just one factor among many that contribute to a person's development and identity, and should not be used as a definitive predictor of their traits or behaviors.
I'm sorry for any confusion, but "social problems" is not a term that has a specific medical definition. It is a broad term used in sociology and social work to refer to issues that affect large numbers of people within a society, such as poverty, discrimination, crime, and substance abuse. These issues can certainly have impacts on individuals' mental and physical health, but they are not considered medical conditions themselves. If you have any questions related to healthcare or medical terminology, I would be happy to try to help answer those!
Bisexuality is a sexual orientation characterized by the attraction to both males and females, or to individuals of any gender identity. It's important to note that bisexuality encompasses a wide range of experiences and attractions, and it does not necessarily mean equal attraction to both genders. Some people who identify as bisexual may experience a stronger attraction to one gender over the other, while others may feel an equal attraction to both.
Bisexuality is often misunderstood or stigmatized, but it is a normal and valid sexual orientation that has been recognized in various forms throughout history and across cultures. It's also important to recognize that bisexuality exists on a spectrum, and some people may identify as pansexual, queer, or fluid, which can also involve attraction to individuals of multiple genders. Ultimately, the most important thing is for each person to define their own sexual orientation in a way that feels authentic and true to themselves.
A social stigma is a socially constructed phenomenon where certain individuals or groups are labeled, discriminated against, and excluded because of their perceived differences, which may be based on characteristics such as race, ethnicity, nationality, religion, gender, sexual orientation, age, mental or physical abilities, or health status. These negative attitudes and behaviors can lead to unequal treatment, prejudice, and discrimination, resulting in significant harm to the stigmatized individuals' social, emotional, and psychological well-being.
In medical terms, a social stigma may be associated with certain health conditions, illnesses, or disabilities that are perceived as shameful, undesirable, or deviant by society. For example, people with mental illness, HIV/AIDS, substance use disorders, or sexually transmitted infections may experience social stigma, which can negatively impact their access to healthcare services, treatment outcomes, and overall quality of life.
The negative consequences of social stigma can be reduced through education, awareness, and advocacy efforts that challenge stereotypes, promote understanding and empathy, and foster inclusive and supportive communities.
In the context of medical terminology, "attitude" generally refers to the position or posture of a patient's body or a part of it. It can also refer to the mental set or disposition that a person has towards their health, illness, or healthcare providers. However, it is not a term that has a specific medical definition like other medical terminologies do.
For example, in orthopedics, "attitude" may be used to describe the position of a limb or joint during an examination or surgical procedure. In psychology, "attitude" may refer to a person's feelings, beliefs, and behaviors towards a particular object, issue, or idea related to their health.
Therefore, the meaning of "attitude" in medical terminology can vary depending on the context in which it is used.
I'm sorry for any confusion, but "prejudice" is not a term that has a medical definition in the same way that a term like "myocardial infarction" (heart attack) does. Prejudice is a psychological or sociological concept that refers to preconceived opinions or attitudes about a person or group that are not based on reason or actual experience. It often involves stereotypes and can lead to discrimination or unfair treatment. While prejudice itself is not a medical condition, it can certainly have impacts on mental and physical health, both for those who experience it and for those who hold such biases.
Sexual behavior refers to any physical or emotional interaction that has the potential to lead to sexual arousal and/or satisfaction. This can include a wide range of activities, such as kissing, touching, fondling, oral sex, vaginal sex, anal sex, and masturbation. It can also involve the use of sexual aids, such as vibrators or pornography.
Sexual behavior is influenced by a variety of factors, including biological, psychological, social, and cultural influences. It is an important aspect of human development and relationships, and it is essential to healthy sexual functioning and satisfaction. However, sexual behavior can also be associated with risks, such as sexually transmitted infections (STIs) and unintended pregnancies, and it is important for individuals to engage in safe and responsible sexual practices.
It's important to note that sexual behavior can vary widely among individuals and cultures, and what may be considered normal or acceptable in one culture or context may not be in another. It's also important to recognize that all individuals have the right to make informed decisions about their own sexual behavior and to have their sexual rights and autonomy respected.
HIV (Human Immunodeficiency Virus) infection is a viral illness that progressively attacks and weakens the immune system, making individuals more susceptible to other infections and diseases. The virus primarily infects CD4+ T cells, a type of white blood cell essential for fighting off infections. Over time, as the number of these immune cells declines, the body becomes increasingly vulnerable to opportunistic infections and cancers.
HIV infection has three stages:
1. Acute HIV infection: This is the initial stage that occurs within 2-4 weeks after exposure to the virus. During this period, individuals may experience flu-like symptoms such as fever, fatigue, rash, swollen glands, and muscle aches. The virus replicates rapidly, and the viral load in the body is very high.
2. Chronic HIV infection (Clinical latency): This stage follows the acute infection and can last several years if left untreated. Although individuals may not show any symptoms during this phase, the virus continues to replicate at low levels, and the immune system gradually weakens. The viral load remains relatively stable, but the number of CD4+ T cells declines over time.
3. AIDS (Acquired Immunodeficiency Syndrome): This is the most advanced stage of HIV infection, characterized by a severely damaged immune system and numerous opportunistic infections or cancers. At this stage, the CD4+ T cell count drops below 200 cells/mm3 of blood.
It's important to note that with proper antiretroviral therapy (ART), individuals with HIV infection can effectively manage the virus, maintain a healthy immune system, and significantly reduce the risk of transmission to others. Early diagnosis and treatment are crucial for improving long-term health outcomes and reducing the spread of HIV.
Male Homosexuality in Four Societies
