Hematopoietic Stem Cell Transplantation: Transfer of HEMATOPOIETIC STEM CELLS from BONE MARROW or BLOOD between individuals within the same species (TRANSPLANTATION, HOMOLOGOUS) or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS). Hematopoietic stem cell transplantation has been used as an alternative to BONE MARROW TRANSPLANTATION in the treatment of a variety of neoplasms.Spleen: An encapsulated lymphatic organ through which venous blood filters.Transplantation, Homologous: Transplantation between individuals of the same species. Usually refers to genetically disparate individuals in contradistinction to isogeneic transplantation for genetically identical individuals.Stem Cell Transplantation: The transfer of STEM CELLS from one individual to another within the same species (TRANSPLANTATION, HOMOLOGOUS) or between species (XENOTRANSPLANTATION), or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS). The source and location of the stem cells determines their potency or pluripotency to differentiate into various cell types.Transplantation, Autologous: Transplantation of an individual's own tissue from one site to another site.Liver Transplantation: The transference of a part of or an entire liver from one human or animal to another.Transplantation Conditioning: Preparative treatment of transplant recipient with various conditioning regimens including radiation, immune sera, chemotherapy, and/or immunosuppressive agents, prior to transplantation. Transplantation conditioning is very common before bone marrow transplantation.Bone Marrow Transplantation: The transference of BONE MARROW from one human or animal to another for a variety of purposes including HEMATOPOIETIC STEM CELL TRANSPLANTATION or MESENCHYMAL STEM CELL TRANSPLANTATION.Peripheral Blood Stem Cell Transplantation: Transplantation of stem cells collected from the peripheral blood. It is a less invasive alternative to direct marrow harvesting of hematopoietic stem cells. Enrichment of stem cells in peripheral blood can be achieved by inducing mobilization of stem cells from the BONE MARROW.Graft vs Host Disease: The clinical entity characterized by anorexia, diarrhea, loss of hair, leukopenia, thrombocytopenia, growth retardation, and eventual death brought about by the GRAFT VS HOST REACTION.Kidney Transplantation: The transference of a kidney from one human or animal to another.Cell Transplantation: Transference of cells within an individual, between individuals of the same species, or between individuals of different species.Graft Survival: The survival of a graft in a host, the factors responsible for the survival and the changes occurring within the graft during growth in the host.Heart Transplantation: The transference of a heart from one human or animal to another.Hematologic Neoplasms: Neoplasms located in the blood and blood-forming tissue (the bone marrow and lymphatic tissue). The commonest forms are the various types of LEUKEMIA, of LYMPHOMA, and of the progressive, life-threatening forms of the MYELODYSPLASTIC SYNDROMES.Transplantation Chimera: An organism that, as a result of transplantation of donor tissue or cells, consists of two or more cell lines descended from at least two zygotes. This state may result in the induction of donor-specific TRANSPLANTATION TOLERANCE.Tissue Donors: Individuals supplying living tissue, organs, cells, blood or blood components for transfer or transplantation to histocompatible recipients.Lung Transplantation: The transference of either one or both of the lungs from one human or animal to another.Treatment Outcome: Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.Cord Blood Stem Cell Transplantation: Transplantation of STEM CELLS collected from the fetal blood remaining in the UMBILICAL CORD and the PLACENTA after delivery. Included are the HEMATOPOIETIC STEM CELLS.Transplantation Immunology: A general term for the complex phenomena involved in allo- and xenograft rejection by a host and graft vs host reaction. Although the reactions involved in transplantation immunology are primarily thymus-dependent phenomena of cellular immunity, humoral factors also play a part in late rejection.Graft Rejection: An immune response with both cellular and humoral components, directed against an allogeneic transplant, whose tissue antigens are not compatible with those of the recipient.Immunosuppressive Agents: Agents that suppress immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-CELLS or by inhibiting the activation of HELPER CELLS. While immunosuppression has been brought about in the past primarily to prevent rejection of transplanted organs, new applications involving mediation of the effects of INTERLEUKINS and other CYTOKINES are emerging.Organ Transplantation: Transference of an organ between individuals of the same species or between individuals of different species.Immunosuppression: Deliberate prevention or diminution of the host's immune response. It may be nonspecific as in the administration of immunosuppressive agents (drugs or radiation) or by lymphocyte depletion or may be specific as in desensitization or the simultaneous administration of antigen and immunosuppressive drugs.Islets of Langerhans Transplantation: The transference of pancreatic islets within an individual, between individuals of the same species, or between individuals of different species.T-Lymphocytes: Lymphocytes responsible for cell-mediated immunity. Two types have been identified - cytotoxic (T-LYMPHOCYTES, CYTOTOXIC) and helper T-lymphocytes (T-LYMPHOCYTES, HELPER-INDUCER). They are formed when lymphocytes circulate through the THYMUS GLAND and differentiate to thymocytes. When exposed to an antigen, they divide rapidly and produce large numbers of new T cells sensitized to that antigen.Histocompatibility Testing: Identification of the major histocompatibility antigens of transplant DONORS and potential recipients, usually by serological tests. Donor and recipient pairs should be of identical ABO blood group, and in addition should be matched as closely as possible for HISTOCOMPATIBILITY ANTIGENS in order to minimize the likelihood of allograft rejection. (King, Dictionary of Genetics, 4th ed)Whole-Body Irradiation: Irradiation of the whole body with ionizing or non-ionizing radiation. It is applicable to humans or animals but not to microorganisms.Myeloablative Agonists: Agents that destroy bone marrow activity. They are used to prepare patients for BONE MARROW TRANSPLANTATION or STEM CELL TRANSPLANTATION.Transplantation, Isogeneic: Transplantation between genetically identical individuals, i.e., members of the same species with identical histocompatibility antigens, such as monozygotic twins, members of the same inbred strain, or members of a hybrid population produced by crossing certain inbred strains.Histocompatibility: The degree of antigenic similarity between the tissues of different individuals, which determines the acceptance or rejection of allografts.Transplantation: Transference of a tissue or organ from either an alive or deceased donor, within an individual, between individuals of the same species, or between individuals of different species.Retrospective Studies: Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.Time Factors: Elements of limited time intervals, contributing to particular results or situations.Recurrence: The return of a sign, symptom, or disease after a remission.Mesenchymal Stem Cell Transplantation: Transfer of MESENCHYMAL STEM CELLS between individuals within the same species (TRANSPLANTATION, HOMOLOGOUS) or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS).Pancreas Transplantation: The transference of a pancreas from one human or animal to another.Busulfan: An alkylating agent having a selective immunosuppressive effect on BONE MARROW. It has been used in the palliative treatment of chronic myeloid leukemia (MYELOID LEUKEMIA, CHRONIC), but although symptomatic relief is provided, no permanent remission is brought about. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), busulfan is listed as a known carcinogen.Mice, Inbred BALB CMice, Inbred C57BLAntilymphocyte Serum: Serum containing GAMMA-GLOBULINS which are antibodies for lymphocyte ANTIGENS. It is used both as a test for HISTOCOMPATIBILITY and therapeutically in TRANSPLANTATION.Combined Modality Therapy: The treatment of a disease or condition by several different means simultaneously or sequentially. Chemoimmunotherapy, RADIOIMMUNOTHERAPY, chemoradiotherapy, cryochemotherapy, and SALVAGE THERAPY are seen most frequently, but their combinations with each other and surgery are also used.Mice, Inbred Strains: Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations, or by parent x offspring matings carried out with certain restrictions. All animals within an inbred strain trace back to a common ancestor in the twentieth generation.Multiple Myeloma: A malignancy of mature PLASMA CELLS engaging in monoclonal immunoglobulin production. It is characterized by hyperglobulinemia, excess Bence-Jones proteins (free monoclonal IMMUNOGLOBULIN LIGHT CHAINS) in the urine, skeletal destruction, bone pain, and fractures. Other features include ANEMIA; HYPERCALCEMIA; and RENAL INSUFFICIENCY.Remission Induction: Therapeutic act or process that initiates a response to a complete or partial remission level.Lymphocyte Transfusion: The transfer of lymphocytes from a donor to a recipient or reinfusion to the donor.Melphalan: An alkylating nitrogen mustard that is used as an antineoplastic in the form of the levo isomer - MELPHALAN, the racemic mixture - MERPHALAN, and the dextro isomer - MEDPHALAN; toxic to bone marrow, but little vesicant action; potential carcinogen.Survival Analysis: A class of statistical procedures for estimating the survival function (function of time, starting with a population 100% well at a given time and providing the percentage of the population still well at later times). The survival analysis is then used for making inferences about the effects of treatments, prognostic factors, exposures, and other covariates on the function.Living Donors: Non-cadaveric providers of organs for transplant to related or non-related recipients.Cyclophosphamide: Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the LIVER to form the active aldophosphamide. It has been used in the treatment of LYMPHOMA and LEUKEMIA. Its side effect, ALOPECIA, has been used for defleecing sheep. Cyclophosphamide may also cause sterility, birth defects, mutations, and cancer.Survival Rate: The proportion of survivors in a group, e.g., of patients, studied and followed over a period, or the proportion of persons in a specified group alive at the beginning of a time interval who survive to the end of the interval. It is often studied using life table methods.Leukemia: A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. Acute leukemias consist of predominately immature cells; chronic leukemias are composed of more mature cells. (From The Merck Manual, 2006)Graft vs Leukemia Effect: Immunological rejection of leukemia cells following bone marrow transplantation.Antibody Formation: The production of ANTIBODIES by proliferating and differentiated B-LYMPHOCYTES under stimulation by ANTIGENS.Vidarabine: A nucleoside antibiotic isolated from Streptomyces antibioticus. It has some antineoplastic properties and has broad spectrum activity against DNA viruses in cell cultures and significant antiviral activity against infections caused by a variety of viruses such as the herpes viruses, the VACCINIA VIRUS and varicella zoster virus.Transplantation Tolerance: An induced state of non-reactivity to grafted tissue from a donor organism that would ordinarily trigger a cell-mediated or humoral immune response.Disease-Free Survival: Period after successful treatment in which there is no appearance of the symptoms or effects of the disease.Lymphocytes: White blood cells formed in the body's lymphoid tissue. The nucleus is round or ovoid with coarse, irregularly clumped chromatin while the cytoplasm is typically pale blue with azurophilic (if any) granules. Most lymphocytes can be classified as either T or B (with subpopulations of each), or NATURAL KILLER CELLS.HLA Antigens: Antigens determined by leukocyte loci found on chromosome 6, the major histocompatibility loci in humans. They are polypeptides or glycoproteins found on most nucleated cells and platelets, determine tissue types for transplantation, and are associated with certain diseases.Follow-Up Studies: Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.Hemolytic Plaque Technique: A method to identify and enumerate cells that are synthesizing ANTIBODIES against ANTIGENS or HAPTENS conjugated to sheep RED BLOOD CELLS. The sheep red blood cells surrounding cells secreting antibody are lysed by added COMPLEMENT producing a clear zone of HEMOLYSIS. (From Illustrated Dictionary of Immunology, 3rd ed)Transplantation, Heterotopic: Transplantation of tissue typical of one area to a different recipient site. The tissue may be autologous, heterologous, or homologous.Concanavalin A: A MANNOSE/GLUCOSE binding lectin isolated from the jack bean (Canavalia ensiformis). It is a potent mitogen used to stimulate cell proliferation in lymphocytes, primarily T-lymphocyte, cultures.Cells, Cultured: Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.Graft vs Tumor Effect: Immunological rejection of tumor tissue/cells following bone marrow transplantation.Graft vs Host Reaction: An immunological attack mounted by a graft against the host because of tissue incompatibility when immunologically competent cells are transplanted to an immunologically incompetent host; the resulting clinical picture is that of GRAFT VS HOST DISEASE.Lymphocyte Depletion: Immunosuppression by reduction of circulating lymphocytes or by T-cell depletion of bone marrow. The former may be accomplished in vivo by thoracic duct drainage or administration of antilymphocyte serum. The latter is performed ex vivo on bone marrow before its transplantation.Chimerism: The occurrence in an individual of two or more cell populations of different chromosomal constitutions, derived from different individuals. This contrasts with MOSAICISM in which the different cell populations are derived from a single individual.Lymphocyte Activation: Morphologic alteration of small B LYMPHOCYTES or T LYMPHOCYTES in culture into large blast-like cells able to synthesize DNA and RNA and to divide mitotically. It is induced by INTERLEUKINS; MITOGENS such as PHYTOHEMAGGLUTININS, and by specific ANTIGENS. It may also occur in vivo as in GRAFT REJECTION.Leukemia, Myeloid, Acute: Clonal expansion of myeloid blasts in bone marrow, blood, and other tissue. Myeloid leukemias develop from changes in cells that normally produce NEUTROPHILS; BASOPHILS; EOSINOPHILS; and MONOCYTES.Heart-Lung Transplantation: The simultaneous, or near simultaneous, transference of heart and lungs from one human or animal to another.Unrelated Donors: Providers of tissues for transplant to non-related individuals.Cyclosporine: A cyclic undecapeptide from an extract of soil fungi. It is a powerful immunosupressant with a specific action on T-lymphocytes. It is used for the prophylaxis of graft rejection in organ and tissue transplantation. (From Martindale, The Extra Pharmacopoeia, 30th ed).Hepatic Veno-Occlusive Disease: Liver disease that is caused by injuries to the ENDOTHELIAL CELLS of the vessels and subendothelial EDEMA, but not by THROMBOSIS. Extracellular matrix, rich in FIBRONECTINS, is usually deposited around the HEPATIC VEINS leading to venous outflow occlusion and sinusoidal obstruction.Immune Tolerance: The specific failure of a normally responsive individual to make an immune response to a known antigen. It results from previous contact with the antigen by an immunologically immature individual (fetus or neonate) or by an adult exposed to extreme high-dose or low-dose antigen, or by exposure to radiation, antimetabolites, antilymphocytic serum, etc.Immunization, Passive: Transfer of immunity from immunized to non-immune host by administration of serum antibodies, or transplantation of lymphocytes (ADOPTIVE TRANSFER).Mice, Inbred C3HTissue and Organ Procurement: The administrative procedures involved with acquiring TISSUES or organs for TRANSPLANTATION through various programs, systems, or organizations. These procedures include obtaining consent from TISSUE DONORS and arranging for transportation of donated tissues and organs, after TISSUE HARVESTING, to HOSPITALS for processing and transplantation.Antineoplastic Combined Chemotherapy Protocols: The use of two or more chemicals simultaneously or sequentially in the drug therapy of neoplasms. The drugs need not be in the same dosage form.Siblings: Persons or animals having at least one parent in common. (American College Dictionary, 3d ed)Hematopoietic Stem Cells: Progenitor cells from which all blood cells derive.Hematopoietic Stem Cell Mobilization: The release of stem cells from the bone marrow into the peripheral blood circulation for the purpose of leukapheresis, prior to stem cell transplantation. Hematopoietic growth factors or chemotherapeutic agents often are used to stimulate the mobilization.Fetal Tissue Transplantation: Transference of fetal tissue between individuals of the same species or between individuals of different species.Transplantation, Heterologous: Transplantation between animals of different species.Salvage Therapy: A therapeutic approach, involving chemotherapy, radiation therapy, or surgery, after initial regimens have failed to lead to improvement in a patient's condition. Salvage therapy is most often used for neoplastic diseases.Antibodies, Monoclonal: Antibodies produced by a single clone of cells.B-Lymphocytes: Lymphoid cells concerned with humoral immunity. They are short-lived cells resembling bursa-derived lymphocytes of birds in their production of immunoglobulin upon appropriate stimulation.Cytomegalovirus Infections: Infection with CYTOMEGALOVIRUS, characterized by enlarged cells bearing intranuclear inclusions. Infection may be in almost any organ, but the salivary glands are the most common site in children, as are the lungs in adults.Thymus Gland: A single, unpaired primary lymphoid organ situated in the MEDIASTINUM, extending superiorly into the neck to the lower edge of the THYROID GLAND and inferiorly to the fourth costal cartilage. It is necessary for normal development of immunologic function early in life. By puberty, it begins to involute and much of the tissue is replaced by fat.Hematologic Diseases: Disorders of the blood and blood forming tissues.Acute Disease: Disease having a short and relatively severe course.Bone Marrow Cells: Cells contained in the bone marrow including fat cells (see ADIPOCYTES); STROMAL CELLS; MEGAKARYOCYTES; and the immediate precursors of most blood cells.Mice, Inbred CBADonor Selection: The procedure established to evaluate the health status and risk factors of the potential DONORS of biological materials. Donors are selected based on the principles that their health will not be compromised in the process, and the donated materials, such as TISSUES or organs, are safe for reuse in the recipients.Lymphoma, Non-Hodgkin: Any of a group of malignant tumors of lymphoid tissue that differ from HODGKIN DISEASE, being more heterogeneous with respect to malignant cell lineage, clinical course, prognosis, and therapy. The only common feature among these tumors is the absence of giant REED-STERNBERG CELLS, a characteristic of Hodgkin's disease.Immunity, Cellular: Manifestations of the immune response which are mediated by antigen-sensitized T-lymphocytes via lymphokines or direct cytotoxicity. This takes place in the absence of circulating antibody or where antibody plays a subordinate role.Myelodysplastic Syndromes: Clonal hematopoietic stem cell disorders characterized by dysplasia in one or more hematopoietic cell lineages. They predominantly affect patients over 60, are considered preleukemic conditions, and have high probability of transformation into ACUTE MYELOID LEUKEMIA.Liver Failure: Severe inability of the LIVER to perform its normal metabolic functions, as evidenced by severe JAUNDICE and abnormal serum levels of AMMONIA; BILIRUBIN; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; LACTATE DEHYDROGENASES; and albumin/globulin ratio. (Blakiston's Gould Medical Dictionary, 4th ed)Antibody-Producing Cells: Cells of the lymphoid series that can react with antigen to produce specific cell products called antibodies. Various cell subpopulations, often B-lymphocytes, can be defined, based on the different classes of immunoglobulins that they synthesize.Antigens, CD34: Glycoproteins found on immature hematopoietic cells and endothelial cells. They are the only molecules to date whose expression within the blood system is restricted to a small number of progenitor cells in the bone marrow.Bone Marrow: The soft tissue filling the cavities of bones. Bone marrow exists in two types, yellow and red. Yellow marrow is found in the large cavities of large bones and consists mostly of fat cells and a few primitive blood cells. Red marrow is a hematopoietic tissue and is the site of production of erythrocytes and granular leukocytes. Bone marrow is made up of a framework of connective tissue containing branching fibers with the frame being filled with marrow cells.Postoperative Complications: Pathologic processes that affect patients after a surgical procedure. They may or may not be related to the disease for which the surgery was done, and they may or may not be direct results of the surgery.Cytotoxicity, Immunologic: The phenomenon of target cell destruction by immunologically active effector cells. It may be brought about directly by sensitized T-lymphocytes or by lymphoid or myeloid "killer" cells, or it may be mediated by cytotoxic antibody, cytotoxic factor released by lymphoid cells, or complement.Precursor Cell Lymphoblastic Leukemia-Lymphoma: A neoplasm characterized by abnormalities of the lymphoid cell precursors leading to excessive lymphoblasts in the marrow and other organs. It is the most common cancer in children and accounts for the vast majority of all childhood leukemias.Tacrolimus: A macrolide isolated from the culture broth of a strain of Streptomyces tsukubaensis that has strong immunosuppressive activity in vivo and prevents the activation of T-lymphocytes in response to antigenic or mitogenic stimulation in vitro.Anemia, Aplastic: A form of anemia in which the bone marrow fails to produce adequate numbers of peripheral blood elements.Prognosis: A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.Skin Transplantation: The grafting of skin in humans or animals from one site to another to replace a lost portion of the body surface skin.Liver: A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.Hematopoiesis: The development and formation of various types of BLOOD CELLS. Hematopoiesis can take place in the BONE MARROW (medullary) or outside the bone marrow (HEMATOPOIESIS, EXTRAMEDULLARY).Hodgkin Disease: A malignant disease characterized by progressive enlargement of the lymph nodes, spleen, and general lymphoid tissue. In the classical variant, giant usually multinucleate Hodgkin's and REED-STERNBERG CELLS are present; in the nodular lymphocyte predominant variant, lymphocytic and histiocytic cells are seen.Leukemia, Myelogenous, Chronic, BCR-ABL Positive: Clonal hematopoetic disorder caused by an acquired genetic defect in PLURIPOTENT STEM CELLS. It starts in MYELOID CELLS of the bone marrow, invades the blood and then other organs. The condition progresses from a stable, more indolent, chronic phase (LEUKEMIA, MYELOID, CHRONIC PHASE) lasting up to 7 years, to an advanced phase composed of an accelerated phase (LEUKEMIA, MYELOID, ACCELERATED PHASE) and BLAST CRISIS.T-Lymphocytes, Regulatory: CD4-positive T cells that inhibit immunopathology or autoimmune disease in vivo. They inhibit the immune response by influencing the activity of other cell types. Regulatory T-cells include naturally occurring CD4+CD25+ cells, IL-10 secreting Tr1 cells, and Th3 cells.Cell Differentiation: Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs.Risk Factors: An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.Flow Cytometry: Technique using an instrument system for making, processing, and displaying one or more measurements on individual cells obtained from a cell suspension. Cells are usually stained with one or more fluorescent dyes specific to cell components of interest, e.g., DNA, and fluorescence of each cell is measured as it rapidly transverses the excitation beam (laser or mercury arc lamp). Fluorescence provides a quantitative measure of various biochemical and biophysical properties of the cell, as well as a basis for cell sorting. Other measurable optical parameters include light absorption and light scattering, the latter being applicable to the measurement of cell size, shape, density, granularity, and stain uptake.Lymphoma: A general term for various neoplastic diseases of the lymphoid tissue.Disease Models, Animal: Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.Host vs Graft Reaction: The immune responses of a host to a graft. A specific response is GRAFT REJECTION.Granulocyte Colony-Stimulating Factor: A glycoprotein of MW 25 kDa containing internal disulfide bonds. It induces the survival, proliferation, and differentiation of neutrophilic granulocyte precursor cells and functionally activates mature blood neutrophils. Among the family of colony-stimulating factors, G-CSF is the most potent inducer of terminal differentiation to granulocytes and macrophages of leukemic myeloid cell lines.Isoantigens: Antigens that exist in alternative (allelic) forms in a single species. When an isoantigen is encountered by species members who lack it, an immune response is induced. Typical isoantigens are the BLOOD GROUP ANTIGENS.Rats, Inbred LewMice, Inbred DBATissue Transplantation: Transference of tissue within an individual, between individuals of the same species, or between individuals of different species.Cytarabine: A pyrimidine nucleoside analog that is used mainly in the treatment of leukemia, especially acute non-lymphoblastic leukemia. Cytarabine is an antimetabolite antineoplastic agent that inhibits the synthesis of DNA. Its actions are specific for the S phase of the cell cycle. It also has antiviral and immunosuppressant properties. (From Martindale, The Extra Pharmacopoeia, 30th ed, p472)Killer Cells, Natural: Bone marrow-derived lymphocytes that possess cytotoxic properties, classically directed against transformed and virus-infected cells. Unlike T CELLS; and B CELLS; NK CELLS are not antigen specific. The cytotoxicity of natural killer cells is determined by the collective signaling of an array of inhibitory and stimulatory CELL SURFACE RECEPTORS. A subset of T-LYMPHOCYTES referred to as NATURAL KILLER T CELLS shares some of the properties of this cell type.Infection: Invasion of the host organism by microorganisms that can cause pathological conditions or diseases.Lymphocyte Culture Test, Mixed: Measure of histocompatibility at the HL-A locus. Peripheral blood lymphocytes from two individuals are mixed together in tissue culture for several days. Lymphocytes from incompatible individuals will stimulate each other to proliferate significantly (measured by tritiated thymidine uptake) whereas those from compatible individuals will not. In the one-way MLC test, the lymphocytes from one of the individuals are inactivated (usually by treatment with MITOMYCIN or radiation) thereby allowing only the untreated remaining population of cells to proliferate in response to foreign histocompatibility antigens.Corneal Transplantation: Partial or total replacement of the CORNEA from one human or animal to another.Severe Combined Immunodeficiency: Group of rare congenital disorders characterized by impairment of both humoral and cell-mediated immunity, leukopenia, and low or absent antibody levels. It is inherited as an X-linked or autosomal recessive defect. Mutations occurring in many different genes cause human Severe Combined Immunodeficiency (SCID).Isoantibodies: Antibodies from an individual that react with ISOANTIGENS of another individual of the same species.Radiation Chimera: An organism whose body contains cell populations of different genotypes as a result of the TRANSPLANTATION of donor cells after sufficient ionizing radiation to destroy the mature recipient's cells which would otherwise reject the donor cells.Antigens: Substances that are recognized by the immune system and induce an immune reaction.Brain Tissue Transplantation: Transference of brain tissue, either from a fetus or from a born individual, between individuals of the same species or between individuals of different species.Cell SeparationLiver Diseases: Pathological processes of the LIVER.Waiting Lists: Prospective patient listings for appointments or treatments.Histocompatibility Antigens: A group of antigens that includes both the major and minor histocompatibility antigens. The former are genetically determined by the major histocompatibility complex. They determine tissue type for transplantation and cause allograft rejections. The latter are systems of allelic alloantigens that can cause weak transplant rejection.Prospective Studies: Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.Carmustine: A cell-cycle phase nonspecific alkylating antineoplastic agent. It is used in the treatment of brain tumors and various other malignant neoplasms. (From Martindale, The Extra Pharmacopoeia, 30th ed, p462) This substance may reasonably be anticipated to be a carcinogen according to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (From Merck Index, 11th ed)Neoplasm Transplantation: Experimental transplantation of neoplasms in laboratory animals for research purposes.Fatal Outcome: Death resulting from the presence of a disease in an individual, as shown by a single case report or a limited number of patients. This should be differentiated from DEATH, the physiological cessation of life and from MORTALITY, an epidemiological or statistical concept.Cytotoxicity Tests, Immunologic: The demonstration of the cytotoxic effect on a target cell of a lymphocyte, a mediator released by a sensitized lymphocyte, an antibody, or complement.Etoposide: A semisynthetic derivative of PODOPHYLLOTOXIN that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitotic phase of cell division, and lead to cell death. Etoposide acts primarily in the G2 and S phases of the cell cycle.Lymphoproliferative Disorders: Disorders characterized by proliferation of lymphoid tissue, general or unspecified.Stem Cells: Relatively undifferentiated cells that retain the ability to divide and proliferate throughout postnatal life to provide progenitor cells that can differentiate into specialized cells.Interferon-gamma: The major interferon produced by mitogenically or antigenically stimulated LYMPHOCYTES. It is structurally different from TYPE I INTERFERON and its major activity is immunoregulation. It has been implicated in the expression of CLASS II HISTOCOMPATIBILITY ANTIGENS in cells that do not normally produce them, leading to AUTOIMMUNE DISEASES.Macrophages: The relatively long-lived phagocytic cell of mammalian tissues that are derived from blood MONOCYTES. Main types are PERITONEAL MACROPHAGES; ALVEOLAR MACROPHAGES; HISTIOCYTES; KUPFFER CELLS of the liver; and OSTEOCLASTS. They may further differentiate within chronic inflammatory lesions to EPITHELIOID CELLS or may fuse to form FOREIGN BODY GIANT CELLS or LANGHANS GIANT CELLS. (from The Dictionary of Cell Biology, Lackie and Dow, 3rd ed.)Thymectomy: Surgical removal of the thymus gland. (Dorland, 28th ed)Blood Group Incompatibility: An antigenic mismatch between donor and recipient blood. Antibodies present in the recipient's serum may be directed against antigens in the donor product. Such a mismatch may result in a transfusion reaction in which, for example, donor blood is hemolyzed. (From Saunders Dictionary & Encyclopedia of Laboratory Medicine and Technology, 1984).Immunization: Deliberate stimulation of the host's immune response. ACTIVE IMMUNIZATION involves administration of ANTIGENS or IMMUNOLOGIC ADJUVANTS. PASSIVE IMMUNIZATION involves administration of IMMUNE SERA or LYMPHOCYTES or their extracts (e.g., transfer factor, immune RNA) or transplantation of immunocompetent cell producing tissue (thymus or bone marrow).Minor Histocompatibility Antigens: Allelic alloantigens often responsible for weak graft rejection in cases when (major) histocompatibility has been established by standard tests. In the mouse they are coded by more than 500 genes at up to 30 minor histocompatibility loci. The most well-known minor histocompatibility antigen in mammals is the H-Y antigen.Immunocompromised Host: A human or animal whose immunologic mechanism is deficient because of an immunodeficiency disorder or other disease or as the result of the administration of immunosuppressive drugs or radiation.Splenectomy: Surgical procedure involving either partial or entire removal of the spleen.Neoplasm, Residual: Remnant of a tumor or cancer after primary, potentially curative therapy. (Dr. Daniel Masys, written communication)Bronchiolitis Obliterans: Inflammation of the BRONCHIOLES leading to an obstructive lung disease. Bronchioles are characterized by fibrous granulation tissue with bronchial exudates in the lumens. Clinical features include a nonproductive cough and DYSPNEA.Mitogens: Substances that stimulate mitosis and lymphocyte transformation. They include not only substances associated with LECTINS, but also substances from streptococci (associated with streptolysin S) and from strains of alpha-toxin-producing staphylococci. (Stedman, 25th ed)Cytomegalovirus: A genus of the family HERPESVIRIDAE, subfamily BETAHERPESVIRINAE, infecting the salivary glands, liver, spleen, lungs, eyes, and other organs, in which they produce characteristically enlarged cells with intranuclear inclusions. Infection with Cytomegalovirus is also seen as an opportunistic infection in AIDS.Mycophenolic Acid: An antibiotic substance derived from Penicillium stoloniferum, and related species. It blocks de novo biosynthesis of purine nucleotides by inhibition of the enzyme inosine monophosphate dehydrogenase. Mycophenolic acid is important because of its selective effects on the immune system. It prevents the proliferation of T-cells, lymphocytes, and the formation of antibodies from B-cells. It also may inhibit recruitment of leukocytes to inflammatory sites. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p1301)Hypersensitivity, Delayed: An increased reactivity to specific antigens mediated not by antibodies but by cells.Interleukin-2: A soluble substance elaborated by antigen- or mitogen-stimulated T-LYMPHOCYTES which induces DNA synthesis in naive lymphocytes.Leukapheresis: The preparation of leukocyte concentrates with the return of red cells and leukocyte-poor plasma to the donor.Cadaver: A dead body, usually a human body.Lymph Nodes: They are oval or bean shaped bodies (1 - 30 mm in diameter) located along the lymphatic system.Dose-Response Relationship, Immunologic: A specific immune response elicited by a specific dose of an immunologically active substance or cell in an organism, tissue, or cell.Virus Activation: The mechanism by which latent viruses, such as genetically transmitted tumor viruses (PROVIRUSES) or PROPHAGES of lysogenic bacteria, are induced to replicate and then released as infectious viruses. It may be effected by various endogenous and exogenous stimuli, including B-cell LIPOPOLYSACCHARIDES, glucocorticoid hormones, halogenated pyrimidines, IONIZING RADIATION, ultraviolet light, and superinfecting viruses.Leukemia, Myeloid: Form of leukemia characterized by an uncontrolled proliferation of the myeloid lineage and their precursors (MYELOID PROGENITOR CELLS) in the bone marrow and other sites.Allografts: Tissues, cells, or organs transplanted between genetically different individuals of the same species.Bone Marrow Purging: Techniques for the removal of subpopulations of cells (usually residual tumor cells) from the bone marrow ex vivo before it is infused. The purging is achieved by a variety of agents including pharmacologic agents, biophysical agents (laser photoirradiation or radioisotopes) and immunologic agents. Bone marrow purging is used in both autologous and allogeneic BONE MARROW TRANSPLANTATION.Cytokines: Non-antibody proteins secreted by inflammatory leukocytes and some non-leukocytic cells, that act as intercellular mediators. They differ from classical hormones in that they are produced by a number of tissue or cell types rather than by specialized glands. They generally act locally in a paracrine or autocrine rather than endocrine manner.Leukocyte Count: The number of WHITE BLOOD CELLS per unit volume in venous BLOOD. A differential leukocyte count measures the relative numbers of the different types of white cells.T-Lymphocytes, Cytotoxic: Immunized T-lymphocytes which can directly destroy appropriate target cells. These cytotoxic lymphocytes may be generated in vitro in mixed lymphocyte cultures (MLC), in vivo during a graft-versus-host (GVH) reaction, or after immunization with an allograft, tumor cell or virally transformed or chemically modified target cell. The lytic phenomenon is sometimes referred to as cell-mediated lympholysis (CML). These CD8-positive cells are distinct from NATURAL KILLER CELLS and NATURAL KILLER T-CELLS. There are two effector phenotypes: TC1 and TC2.Opportunistic Infections: An infection caused by an organism which becomes pathogenic under certain conditions, e.g., during immunosuppression.Chimera: An individual that contains cell populations derived from different zygotes.Leukemia, Experimental: Leukemia induced experimentally in animals by exposure to leukemogenic agents, such as VIRUSES; RADIATION; or by TRANSPLANTATION of leukemic tissues.Chronic Disease: Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care. (Dictionary of Health Services Management, 2d ed)Mice, SCID: Mice homozygous for the mutant autosomal recessive gene "scid" which is located on the centromeric end of chromosome 16. These mice lack mature, functional lymphocytes and are thus highly susceptible to lethal opportunistic infections if not chronically treated with antibiotics. The lack of B- and T-cell immunity resembles severe combined immunodeficiency (SCID) syndrome in human infants. SCID mice are useful as animal models since they are receptive to implantation of a human immune system producing SCID-human (SCID-hu) hematochimeric mice.Immunoglobulin G: The major immunoglobulin isotype class in normal human serum. There are several isotype subclasses of IgG, for example, IgG1, IgG2A, and IgG2B.Antineoplastic Agents: Substances that inhibit or prevent the proliferation of NEOPLASMS.Lymphocyte Count: The number of LYMPHOCYTES per unit volume of BLOOD.Transplants: Organs, tissues, or cells taken from the body for grafting into another area of the same body or into another individual.Thiotepa: A very toxic alkylating antineoplastic agent also used as an insect sterilant. It causes skin, gastrointestinal, CNS, and bone marrow damage. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), thiotepa may reasonably be anticipated to be a carcinogen (Merck Index, 11th ed).CD4-Positive T-Lymphocytes: A critical subpopulation of T-lymphocytes involved in the induction of most immunological functions. The HIV virus has selective tropism for the T4 cell which expresses the CD4 phenotypic marker, a receptor for HIV. In fact, the key element in the profound immunosuppression seen in HIV infection is the depletion of this subset of T-lymphocytes.Antibodies, Neoplasm: Immunoglobulins induced by antigens specific for tumors other than the normally occurring HISTOCOMPATIBILITY ANTIGENS.Incidence: The number of new cases of a given disease during a given period in a specified population. It also is used for the rate at which new events occur in a defined population. It is differentiated from PREVALENCE, which refers to all cases, new or old, in the population at a given time.Mice, Inbred AKRErythrocytes: Red blood cells. Mature erythrocytes are non-nucleated, biconcave disks containing HEMOGLOBIN whose function is to transport OXYGEN.Vincristine: An antitumor alkaloid isolated from VINCA ROSEA. (Merck, 11th ed.)Neoplasms, Experimental: Experimentally induced new abnormal growth of TISSUES in animals to provide models for studying human neoplasms.Trinitrobenzenes: Benzene derivatives which are substituted with three nitro groups in any position.Autoimmune Diseases: Disorders that are characterized by the production of antibodies that react with host tissues or immune effector cells that are autoreactive to endogenous peptides.Epitopes: Sites on an antigen that interact with specific antibodies.Cell Count: The number of CELLS of a specific kind, usually measured per unit volume or area of sample.Facial Transplantation: The transference between individuals of the entire face or major facial structures. In addition to the skin and cartilaginous tissue (CARTILAGE), it may include muscle and bone as well.Splenomegaly: Enlargement of the spleen.Antineoplastic Agents, Alkylating: A class of drugs that differs from other alkylating agents used clinically in that they are monofunctional and thus unable to cross-link cellular macromolecules. Among their common properties are a requirement for metabolic activation to intermediates with antitumor efficacy and the presence in their chemical structures of N-methyl groups, that after metabolism, can covalently modify cellular DNA. The precise mechanisms by which each of these drugs acts to kill tumor cells are not completely understood. (From AMA, Drug Evaluations Annual, 1994, p2026)Fetal Blood: Blood of the fetus. Exchange of nutrients and waste between the fetal and maternal blood occurs via the PLACENTA. The cord blood is blood contained in the umbilical vessels (UMBILICAL CORD) at the time of delivery.Immunophenotyping: Process of classifying cells of the immune system based on structural and functional differences. The process is commonly used to analyze and sort T-lymphocytes into subsets based on CD antigens by the technique of flow cytometry.Immunotherapy, Adoptive: Form of adoptive transfer where cells with antitumor activity are transferred to the tumor-bearing host in order to mediate tumor regression. The lymphoid cells commonly used are lymphokine-activated killer (LAK) cells and tumor-infiltrating lymphocytes (TIL). This is usually considered a form of passive immunotherapy. (From DeVita, et al., Cancer, 1993, pp.305-7, 314)Prednisone: A synthetic anti-inflammatory glucocorticoid derived from CORTISONE. It is biologically inert and converted to PREDNISOLONE in the liver.

*Ronald D. Guttmann

Guttmann, R.D., Aust, J.B.: Acquired tolerance to homografts produced by homologous spleen cell injection in adult mice. Nature ... Canadian Transplantation Society [4], XVII World Congress of The Transplantation Society Inc. [5], is a Fellow of the Royal ... now called American Society of Transplantation. [16](1982). Co-founder and President of the Canadian Transplantation Society [ ... Transplantation Reviews 6:189-193, 1992. cited in: Human Rights Watch Report on Judicial Execution in China.[19] Guttmann, R.D ...

*Lactate dehydrogenase elevating virus

The virus is most commonly found in the liver, spleen, lymph nodes, and skin. The main effect of the virus on the host cell is ... LDV has a remarkably narrow cell type specificity, meaning nothing homologous with LDV in mice has been found in another ... activity within three days of the transplantation. This occurred even before the tumors were obvious clinically. In further ... The first cells it was shown to replicate in were primary mouse embryo cell cultures, but these cultures had to be freshly ...

*Hematopoietic stem cell

Hematopoiesis Hematopoietic stem cell niche Hematopoietic stem cell transplantation Birbrair, Alexander; Frenette, Paul S. ( ... which depends on the ability of infused bone marrow cells to give rise to clones of maturing hematopoietic cells in the spleens ... Non-homologous end joining (NHEJ) is a pathway that repairs double-strand breaks in DNA. NHEJ is referred to as "non-homologous ... Lymphoid cells include T cells, B cells, and natural killer cells.) The definition of hematopoietic stem cells has evolved ...

*William Holmes Crosby Jr.

1958 Jan;4(1):82-8. Effect of homologous bone marrow-spleen cell suspension on survival of swine exposed to radiation from a ... sub-dermal bone transplantation, and consumption of radio-labeled iron. In the winter of 1952-1953, he volunteered to be sent ... In 1974, while he was preparing a chapter on the spleen for a textbook on hematology, he included in it his translation of a ... As a hematologist he continued in his research in the metabolism of iron, an essential component of red blood cells. This led ...

*Growth factor

... cells and immune system cells (e.g., lymphocytes and tissue cells from spleen, thymus, and lymph nodes). For the circulatory ... bone marrow transplantation. *angiogenesis for cardiovascular diseases. See also[edit]. *Angiogenesis. *Bone growth factor ... IL-3 - Stimulates production of all non-lymphoid cells.. *IL-4 - Growth factor for activated B cells, resting T cells, and mast ... IL-2 - T-cell growth factor. Stimulates IL-1 synthesis. Activates B-cells and NK cells. ...

*Kidney

Interstitial kidney cells. Gene and protein expression[edit]. Further information: Bioinformatics § Gene and protein expression ... The left sits below the diaphragm and posterior to the spleen. On top of each kidney is an adrenal gland. The upper parts of ... The collecting ducts from each cluster of nephrons usually drain into an archinephric duct, which is homologous with the vas ... Dialysis and kidney transplantation are used to treat kidney failure; one (or both sequentially) of these are almost always ...

*புற்று நோய் - தமிழ் விக்கிப்பீடியா

"Tumorigenic transformation of mammalian cells induced by a normal human gene homologous to the oncogene of Harvey murine ... "Cancer Spread By Transplantation Extremely Rare: In Very Rare Case, Woman Develops Leukemia from Liver Transplant". ... Legend: → tumor ←, ★ central pleural effusion, 1&3 lungs, 2 spine, 4 ribs, 5 aorta, 6 spleen, 7&8 kidneys, 9 liver. ... இவை அந்தந்த உறுப்புகளில் நிலவும் சாதரண குருத்தணுக்களில் (normal stem cells, ex. neuronal stem cells) உள்ள கல குறிகைகளில் (cell ...
Bone marrow transplantation, 2016; doi:10.1038/bmt.2016.123. Authors: Green D J, Bensinger W I, Holmberg L A, Gooley T, Till B G Green D J, Bensinger W I, Holmberg L A, Gooley T, Till B G, Budde L E, Pagel J M, Frayo S L, Roden J E, Hedin L, Press O W, Gopal A K et al.(7) Affiliation: Fred Hutchinson Cancer Research Center, United States; Fred Hutchinson Cancer Research Center, United States; Fred Hutchinson Cancer Research Center, United States; Fred Hutchinson Cancer Research Center, United States; Fred Hutchinson Cancer Research Center, United States Fred Hutchinson Cancer Research Center, United States; Fred Hutchinson Cancer Research Center, United States; Fred Hutchinson Cancer Research Center, United States; Fred Hutchinson Cancer Research Center, United States; Fred Hutchinson Cancer Research Center, United States; City of Hope National Medical Center, Duarte, CA, United States; Fred Hutchinson Cancer Research Center, United States; Fred Hutchinson Cancer Research Center, United ...
OBJECTIVE: To explore the outcome of human leukocyte antigen (HLA)-mismatched/haploidentical hematopoietic stem cell transplantation (HSCT) for refractory/relapsed acute leukemia (AL) patients and its related risk factors.. METHODS: 96 refractory/relapsed AL patients who received HLA-mismatched/haploidentical HSCT following conditioning regimen comprised of modified busulfan/cyclophosphamide (BU/CY) plus thymoglobulin (ATG) from Jan 2003 to Jun 2011 were analyzed retrospectively.. RESULTS: Of the 96 patients, 61 suffered from acute myeloid leukemia (AML), and 35 acute lymphoid leukemia (ALL), all of them in non-remission (NR) or relapse before transplantation. With a median follow-up of 373 (34 - 3157) d, 33 cases (34%) survived, 31 survived without leukemia, and 35 relapsed. The estimated 3-year overall survival (OS) and disease-free survival (DFS) rate was 30.2% and 29.0%, respectively. The 3-year OS rate was significantly higher for AML patients (39.2%) ...
Геморрагический энтерит, ассоциированный с парвовирусом В19 после трансплантации гемопоэтических стволовых клеток: клинический случай и данные литературыHaemorrhagic enteritis associated with parvovirus B19 following hematopoietic stem cell transplantation: a case report and literature data
A nosocomial pneumonia caused by Legionella pneumophilaserogroup 2oc-14oc curred in a 7-year-old patient following allogeneic hematopoietic stem cell transplantation for thalassemia major. The patient was diagnosed as nosocomial Legionella pneumonia by a polymerase chain reaction (PCR) from bronchoalveolar lavage and a culture of L. pneumophilaserogroup 2-14 from patients room faucet water. Legionella was eradicated from our hospitals water distribution system by superheating and chemical eradication methods (hyper-chlorination and hydrogen peroxide). We did not detect any case after this event. Early recognition of contamination of hospital water system with Leigonella proves the importance of prevention new cases. ...
A 60-year-old man presented with impaired consciousness and psychomotor agitation after a second allogeneic haematopoietic stem cell transplantation (HSCT) from a matched unrelated donor for acute myeloid leukaemia. Clinical, biological and radiological evidence suggested a diagnosis of central nervous system graft-versus-host disease (CNS-GvHD). After intrathecal infusion of methylprednisolone, the clinical symptoms as well as the radiological abnormalities disappeared. The present report illustrates the difficulties in the diagnosis and the management of CNS-GvHD, a very rare and still challenging neurological complication that can occur after allogeneic HSCT. ...
TY - JOUR. T1 - Spinal osteomyelitis due to Aspergillus flavus in a child. T2 - A rare complication after haematopoietic stem cell transplantation. AU - Beluffi, Giampiero. AU - Bernardo, Maria Ester. AU - Meloni, Giulia. AU - Spinazzola, Angelo. AU - Locatelli, Franco. PY - 2008/6. Y1 - 2008/6. N2 - We report the case of a child affected by acute myeloid leukaemia who was treated with allogeneic haematopoietic stem cell transplantation and developed cervicothoracic spinal osteomyelitis due to Aspergillus flavus. The diagnosis was difficult on a clinical basis, but made possible by conventional radiography and MRI.. AB - We report the case of a child affected by acute myeloid leukaemia who was treated with allogeneic haematopoietic stem cell transplantation and developed cervicothoracic spinal osteomyelitis due to Aspergillus flavus. The diagnosis was difficult on a clinical basis, but made possible by ...
Purpose of reviewCytomegalovirus (CMV) infection is a common opportunistic infection after allogeneic haematopoietic stem cell transplantation (HSCT). CMV surveillance-preemptive therapy is the current preferred approach for preventing CMV disease after HSCT. In contrast, antiviral prophylaxis is no
TY - JOUR. T1 - Respiratory virus infections in pediatric hematopoietic stem cell transplantation. AU - Luján-Zilbermann, Jorge. AU - Benaim, Ely. AU - Tong, Xin. AU - Srivastava, Deo K.. AU - Patrick, Christian C.. AU - Devincenzo, John. PY - 2001/10/1. Y1 - 2001/10/1. N2 - Respiratory virus infections (RVI) have become an increasingly appreciated problem in the hematopoietic stem cell transplant (HSCT) population. A retrospective analysis of 274 patients undergoing 281 HSCT at St. Jude Childrens Research Hospital from January 1994 through December 1997 was performed. Medical and clinical laboratory records were reviewed beginning at the onset of conditioning through the year following each HSCT, and the analysis was done for the first RVI only. Thirty-two (11%) of 281 HSCT cases developed a RVI during the first year post-HSCT. The most frequent cause of RVI was human parainfluenza virus type 3. Univariate analysis was performed to determine the association ...
TY - JOUR. T1 - Rapid immune reconstitution following autologous hematopoietic stem cell transplantation in children. T2 - A single institution experience. AU - Hoepfner, S.. AU - Haut, Paul. AU - OGorman, M.. AU - Kletzel, M.. PY - 2003/2. Y1 - 2003/2. N2 - In this retrospective study, we review the immune reconstitution of children undergoing autologous hematopoietic stem cell transplantation. A total of 125 patients underwent autologous transplantation between 1992 and 2000. The report includes data on 58 patients. Data were not available on the remaining patients who either died before testing or data were not obtained. The parameters evaluated include: (a) immunophenotype by flow cytometry to quantify lymphocyte subpopulations (b) mitogen stimulation assays, and (c) quantitative immunoglobulins. The analysis reveals that CD3+ cells did not reach the normal range during the first year post-transplant. ...
Background. Haploidentical hematopoietic stem-cell transplantation (haplo-HSCT) is associated with an increased risk of graft failure and severe graft-versus-host disease (GVHD). Marrow mesenchymal stromal cells (MSCs) have been shown to support in vivo normal hematopoiesis and to display potent immunosuppressive effects. We launched a multi-center clinical study to examine the safety and feasibility of co-transplantation of MSCs (from third party donors) and haploidentical HSCs into 35 children with severe aplastic anemia (SAA). Methods. A total of 35 children with SAA were enrolled in this multi-center study between January 2014 and December 2016. All patients met the criteria of HLA-mismatched with ⩾5/10 HLA-matched loci. The conditioning regimen for haploidentical hematopoietic stem cell transplantation consisted of busulfan (Bu), cyclophosphamide and ATG. BM and peripheral blood CD34+ ...
According to a recently published report by Brisk Insights, the Global Hematopoietic Stem Cells Transplantation Market is expected to grow at the CAGR of 10.4 % during 2017-2025. The global hematopoietic stem cells transplantation market is segmented on the basis of application, transplant type, and geography. The report on global hematopoietic stem cells transplantation market (by application, transplant type, and geography) provides a detailed overview and predictive analysis of the market.. Full report available on Hematopoietic Stem Cells Transplantation Market: Global Industry Size, Growth, Share and Forecast to 2025 report at http://www.briskinsights.com/report/hematopoietic-stem-cells-transplantation-market. Market Insights. Increasing prevalence of cancer and anemia in both developed and developing nations are the key growth factors ...
Objectives: Autologous haematopoietic stem cell transplantation (HSCT) with CD34+ cell selection has recently been used in the treatment of refractory Crohns disease, showing good safety and promising efficacy. We investigated the safety and efficacy of HSCT with unselected peripheral blood stem cells (PBSCs) in moderate-severe refractory Crohns disease.. Patients: Four patients (three male, one female; age range 26-45 years) with active moderate-severe Crohns disease (median Crohns Disease Activity Index (CDAI) 319, range 272-345), refractory or intolerant to multiple drugs including infliximab, were enrolled.. Interventions: Unselected PBSCs were collected after mobilisation with cyclophosphamide (CTX) 1.5 g/m2 and granulocyte-colony stimulating factor (G-CSF) 10 μg/kg. The conditioning regimen included CTX 50 mg/kg on days −5 to −2 and rabbit anti-thymocyte globulin (ATG) 2.5 mg/kg on days −4 to −2.. Main outcome measures: Primary ...
TY - JOUR. T1 - The effect of pretransplant interferon therapy on the outcome of unrelated donor hematopoietic stem cell transplantation for patients with chronic myelogenous leukemia in first chronic phase. AU - Lee, Stephanie J.. AU - Klein, John P.. AU - Anasetti, Claudio. AU - Antin, Joseph H.. AU - Loberiza, Fausto R.. AU - Bolwell, Brian J.. AU - Lemaistre, Charles F.. AU - Litzow, Mark R. AU - Marks, David. AU - Waller, Edmund K.. AU - Matlack, Marie. AU - Giralt, Sergio. AU - Horowitz, Mary M.. PY - 2001/12/1. Y1 - 2001/12/1. N2 - Various therapeutic options are available for patients with chronic myelogenous leukemia. Allogeneic stem cell transplantation, though often curative, is associated with high nonrelapse mortality and long-term morbidity, particularly when cells from unrelated donors are used. Many physicians and patients opt for a trial of interferon-α (IFN)-based therapy first, reserving ...
Hotels near Fred Hutchinson Cancer Research Center, Seattle on TripAdvisor: Find 111,494 traveller reviews, 50,608 candid photos, and prices for 276 hotels near Fred Hutchinson Cancer Research Center in Seattle, WA.
TY - JOUR. T1 - Pulmonary graft-versus-host disease after autologous hematopoietic stem cell transplantation. AU - Choi, Sue In. AU - Lee, Eun Joo. AU - Kang, Dong Oh. AU - Lee, Sang Yeub. AU - In, Kwang Ho. AU - Kim, Han Kyeom. AU - Park, Sanghoon. PY - 2016/11/1. Y1 - 2016/11/1. KW - Autologous graft-versus-host disease. KW - Hematopoietic stem cell transplantation. KW - Lung. UR - http://www.scopus.com/inward/record.url?scp=84994388396&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=84994388396&partnerID=8YFLogxK. U2 - 10.3904/kjim.2014.110. DO - 10.3904/kjim.2014.110. M3 - Letter. C2 - 26701227. AN - SCOPUS:84994388396. VL - 31. SP - 1181. EP - 1183. JO - Korean Journal of Internal Medicine. JF - Korean Journal of Internal Medicine. SN - 0494-4712. IS - 6. ER - ...
Leonardo Javier Arcuri published a systematic review comparing patient outcomes when treated with haploidentical vs unrelated donor hematopoietic stem cell transplantation (HSCT)
RATIONALE: Drugs used in chemotherapy, such as carboplatin, thiotepa, and etoposide, work in different ways to stop tumor cells from dividing so they stop growing or die. Combining chemotherapy with autologous stem cell transplantation may allow the doctor to give higher doses of chemotherapy drugs and kill more tumor cells. Isotretinoin may be effective in preventing recurrence of glioma. It is not yet known which regimen of chemotherapy plus autologous stem cell transplantation with or without isotretinoin is more effective in treating recurrent high-grade glioma.. PURPOSE: This randomized phase III trial is studying high-dose chemotherapy or intermediate-dose chemotherapy followed by autologous stem cell transplantation to see how well it works compared to high-dose chemotherapy or intermediate-dose chemotherapy followed by autologous stem cell ...
TY - JOUR. T1 - Risk Assessment in Adult T Cell Leukemia/Lymphoma Treated with Allogeneic Hematopoietic Stem Cell Transplantation. AU - ATL Working Group of the Japan Society for Hematopoietic Cell Transplantation. AU - Yoshimitsu, Makoto. AU - Tanosaki, Ryuji. AU - Kato, Koji. AU - Ishida, Takashi. AU - Choi, Ilseung. AU - Takatsuka, Yoshifusa. AU - Fukuda, Takahiro. AU - Eto, Tetsuya. AU - Hidaka, Michihiro. AU - Uchida, Naoyuki. AU - Miyamoto, Toshihiro. AU - Nakashima, Yasuhiro. AU - Moriuchi, Yukiyoshi. AU - Nagafuji, Koji. AU - Miyazaki, Yasuhiko. AU - Ichinohe, Tatsuo. AU - Takanashi, Minoko. AU - Atsuta, Yoshiko. AU - Utsunomiya, Atae. N1 - Copyright © 2017 The American Society for Blood and Marrow Transplantation. Published by Elsevier Inc. All rights reserved.. PY - 2017/11/16. Y1 - 2017/11/16. N2 - Disease status at allogeneic hematopoietic cell transplantation ...
One of the worlds leading bone marrow transplant experts is recommending a significant change to current transplant practice for patients who need marrow or adult stem cells from an unrelated donor to treat hematologic malignancies. Fred Appelbaum, M.D., director of the Clinical Research Division at Fred Hutchinson Cancer Research Center, asserts that bone marrow - not circulating, peripheral blood, which is the current norm - should be the source for unrelated donor adult stem cells for most patients who require a transplant. The reason: because there is less incidence of chronic graft-versus-host disease (GVHD), which can be a debilitating side effect of transplantation.
This case series describes 7 patients with severe chronic graft-versus-host disease (cGvHD) associated with bronchiolitis obliterans (BO) after allogeneic hematopoietic stem cell transplantation (HCT) who underwent lung transplantation. About 20% of patients with severe cGVHD develop BO, which portends a poor prognosis. Lung transplantation may be performed for severe refractory BO. In this group, 6 patients underwent bilateral lung transplantation and 1 underwent single lung transplantation. Explanted lung pathology confirmed BO in all patients. The median survival after lung transplantation in this group was 24 months. The authors conclude that lung transplantation is a possible therapeutic option for certain patients with severe therapy-refractory BO.. ...
TY - JOUR. T1 - Thalidomide plus dexamethasone as a maintenance therapy after autologous hematopoietic stem cell transplantation improves progression-free survival in multiple myeloma. AU - Maiolino, Angelo. AU - Hungria, Vania T.M.. AU - Garnica, Marcia. AU - Oliveira-Duarte, Gislaine. AU - Oliveira, Luciana C.O.. AU - Mercante, Daniel R.. AU - Miranda, Eliana C.. AU - Quero, Adriana A.. AU - Peres, Ana L.M.. AU - Barros, José C.. AU - Tanaka, Paola. AU - Magalhães, Roberto P.. AU - Rego, Eduardo M.. AU - Lorand-Metze, Irene. AU - Lima, Carmen S.P.. AU - Renault, Ilana Z.. AU - Braggio, Esteban. AU - Chiattone, Carlos. AU - Nucci, Marcio. AU - de Souza, Carmino A.. PY - 2012/10/1. Y1 - 2012/10/1. N2 - Despite the good response of stem cell transplant (SCT) in the treatment of multiple myeloma (MM), most patients relapse or do not achieve complete remission, suggesting that additional treatment is needed. We assessed the impact of thalidomide in maintenance ...
TY - JOUR. T1 - Recipient and donor JAK2 46/1 haplotypes are associated with acute graft-versus-host disease following allogeneic hematopoietic stem cell transplantation. AU - Balassa, Katalin. AU - Krahling, Tunde. AU - Remenyi, Peter. AU - Batai, Arpad. AU - Bors, Andras. AU - Kiss, Katalin Piroska. AU - Torbagyi, Eva. AU - Gopcsa, Laszlo. AU - Lengyel, Lilla. AU - Barta, Aniko. AU - Varga, Gergely. AU - Tordai, A.. AU - Masszi, T.. AU - Andrikovics, H.. PY - 2016/7/7. Y1 - 2016/7/7. N2 - Several genetic polymorphisms have been implicated to affect the outcome of allogeneic hematopoietic stem cell transplantation (allo-HSCT). The role of cytokines in acute graft-versus-host disease (aGvHD) is well established and many of the involved cytokines signal through the Janus kinase (JAK) pathways. In this study, we assessed the association of recipient and donor JAK2 46/1 haplotypes and allo-HSCT outcome in a cohort of 124 acute myeloid leukemia ...
Azole therapy is widely utilized in hematopoietic stem cell transplant (HCT) recipients for the treatment of aspergillus. Complications of voriconazole treatment related to its elevated fluoride content have been described in adults, including reports of symptomatic skeletal fluorosis. We review fluoride levels, clinical, and laboratory data in five pediatric HCT recipients on long-term voriconazole therapy, all found to have elevated serum fluoride levels. Two patients had toxic fluoride levels, one infant had symptoms of significant pain with movement and radiographs confirmed skeletal fluorosis. Monitoring fluoride levels in children, especially with skeletal symptoms, should be considered in patients on long-term voriconazole. ...
Objectives: To carry out a phase I-II trial to elucidate the feasibility and efficacy of high dose cyclophosphamide (CY) supported by autologous peripheral blood stem cell transplantation (PBSCT) in the treatment of severe and refractory autoimmune disease (AD).. Methods: Peripheral blood stem cells (PBSCs) were mobilised during haematological recovery after relatively high dose CY (2 g/m2) for 2 days, followed by administration of granulocyte colony stimulating factor. After collecting PBSCs-more than 2×106 CD34+ cells/kg-by apheresis, CD34+ cells were immunologically selected and cryopreserved. Eight patients were enrolled-five had systemic sclerosis (SSc) alone, one had SSc with systemic lupus erythematosus, one amyopathic dermatomyositis (ADM), and one Wegeners granulomatosis (WG). All of the patients were treated with high dose CY (50 mg/kg) for 4 days and autologous PBSCT.. Results: Haematopoietic reconstitution was ...
The role of autologous peripheral blood stem cell transplantation (APBSCT) in acute myeloid leukaemia (AML) remains controversial. The current study evaluated the application of APBSCT in a large consecutive series of patients with untreated AML, and compared outcome with a predictive model based on MRC AML10 data. Of 148 evaluable patients, 118 patients entered complete remission (CR) after induction therapy comprising three cycles of daunorubicin, cytosine arabinoside and oral 6-thioguanine. Of these patients, 68 (57%) proceeded to consolidation therapy with two courses of intermediate dose cytosine arabinoside, and stem cell mobilisation, and 40 of these patients (34%) underwent the APBSCT procedure after high dose busulphan conditioning. Harvest quality was the main factor precluding APBSCT. Five-year event-free survival (EFS) in patients who achieved CR was 38% and in APBSCT patients was 57%. There were no transplant-related deaths. No significant ...
TY - JOUR. T1 - An outbreak of human parainfluenza virus 3 infection in an outpatient hematopoietic stem cell transplantation clinic. AU - Sydnor, Emily R M. AU - Greer, Amy. AU - Budd, Alicia P.. AU - Pehar, Miriana. AU - Munshaw, Supriya. AU - Neofytos, Dionissios. AU - Perl, Trish M.. AU - Valsamakis, Alexandra. PY - 2012/9/1. Y1 - 2012/9/1. N2 - Background: Parainfluenza viruses cause respiratory tract infections in adults and children, with peak activity during the spring and summer months. Human parainfluenza virus type 3 (hPIV-3) can contribute to significant morbidity and mortality in patients undergoing hematopoietic stem cell transplantation (HSCT). Methods: Automated surveillance software was used to identify an hPIV-3 outbreak in an HSCT clinic. Active surveillance for respiratory illness and infection control measures were instituted. A retrospective molecular investigation of outbreak viral strains was performed by direct ...
TY - JOUR. T1 - Treatment of thrombotic microangiopathy after hematopoietic stem cell transplantation with recombinant human soluble thrombomodulin. AU - Fujiwara, Hideaki. AU - Maeda, Yoshinobu. AU - Sando, Yasuhisa. AU - Nakamura, Makoto. AU - Tani, Katsuma. AU - Ishikawa, Tatsunori. AU - Nishimori, Hisakazu. AU - Matsuoka, Ken-ichi. AU - Fujii, Nobuharu. AU - Kondo, Eisei. AU - Tanimoto, Mitsune. PY - 2015. Y1 - 2015. N2 - BACKGROUND: Transplant-associated thrombotic microangiopathy (TA-TMA) after hematopoietic stem cell transplantation (HSCT) remains a severe complication associated with underlying endothelial damage. TMA has a high mortality rate with no definite treatments and effective treatments are needed. STUDY DESIGN AND METHODS: The study objective was to retrospectively analyze the outcome of patients receiving recombinant human soluble thrombomodulin (rTM), which has cytoprotective effects against calcineurin inhibitor-induced ...
PRIMARY OBJECTIVES:. I. To determine whether mixed or full donor hematopoietic chimerism can be safely established using a non-myeloablative conditioning regimen.. II. To determine whether mixed chimerism can be safely converted to full donor hematopoietic chimerism by infusions of donor lymphocytes (DLI).. III. To evaluate potential efficacy of this approach as a treatment for metastatic renal cancer.. OUTLINE:. CONDITIONING REGIMEN: Patients receive fludarabine phosphate intravenously (IV) on days -4 to -2 and undergo low-dose total-body irradiation (TBI) on day 0.. TRANSPLANTATION: Patients undergo allogeneic peripheral blood stem cell transplant on day 0.. IMMUNOSUPRESSION: Patients receive cyclosporine orally (PO) twice daily (BID) or IV once daily (QD) or BID on days -3 to 35 with taper to day 56, and mycophenolate mofetil PO or IV over 2 hours thrice daily (TID) on days 0-40.. DLI: Patients with stable mixed chimerism on day 56 with no evidence of graft-vs-host ...
TY - JOUR. T1 - A phase I trial of high-dose clofarabine, etoposide, and cyclophosphamide and autologous peripheral blood stem cell transplantation in patients with primary refractory and relapsed and refractory Non-Hodgkin lymphoma. AU - Srivastava, Shivani. AU - Jones, David. AU - Wood, Lisa L.. AU - Schwartz, Jennifer E.. AU - Nelson, Robert P.. AU - Abonour, Rafat. AU - Secrest, Angie. AU - Cox, Elizabeth. AU - Baute, Jay. AU - Sullivan, Cheryl. AU - Kane, Kathleen. AU - Robertson, Michael J.. AU - Farag, Sherif S.. PY - 2011/7/1. Y1 - 2011/7/1. N2 - Clofarabine has significant single-agent activity in patients with indolent and aggressive non-Hodgkin lymphoma and synergizes with DNA-damaging drugs. Treatment, however, may be associated with severe and prolonged myelosuppression. We conducted a phase I trial to determine the maximum tolerated dose (MTD) of clofarabine in combination with high-dose etoposide and cyclophosphamide followed by autologous peripheral blood ...
Unrelated umbilical cord blood stem cell transplant after failure of haploidentical or matched unrelated donor hematopoietic stem cell transplant.
Dimethylsulfoxide (DMSO) is a solvent commonly used for the cryopreservation of autologous peripheral blood stem cells (APBSC). Side effects upon infusion of DMSO-cryopreserved APBSC mainly consist of nausea, emesis, chills, rigors, and cardiovascular events, such as bradyarrhythmia or hypotension.1-4 We report the first MRI documented case of transient global amnesia (TGA) that occurred in the setting of DMSO-cryopreserved APBSC infusion for a relapsing lymphoma.. A 30-year-old man, diagnosed with Hodgkins lymphoma, was admitted to our medical center for autologous peripheral blood stem cell transplantation. His history dates back to May 2006 when he presented with cervical, axillary and mediastinal lymphadenopathy associated with fever, chills, night sweats and weight loss. Pathological diagnosis was Hodgkins lymphoma. The patient was treated with 6 cycles of ABVD chemotherapy (doxorubicin, bleomycin, vinblastine, and dacarbazine) with complete remission ...
HIV-positive patients with lymphoma were previously excluded from receiving autologous blood stem cell transplants as treatment, because of concern that these patients compromised immune systems would have a higher risk of infection and poor graft function due to their need for HIV medications. Results from the clinical trial, presented at the American Society of Hematology (ASH) meetings on December 8 at 4:45 p.m. PST, show the concern of additional risk is unfounded. Patients with HIV-associated lymphoma (HAL) who meet standard eligibility criteria should receive an autologous blood stem cell transplant as standard of care or be enrolled in a National Institutes of Health (NIH)-funded clinical trial.. The single-arm, multi-institutional clinical trial-conducted by the Blood and Marrow Transplant Clinical Trials Network (BMT CTN) in collaboration with the AIDS Malignancy Clinical Trials Consortium (AMC)-followed the progress of 40 patients with treatable HIV-1 infection 15 ...
TY - JOUR. T1 - More immune dysregulation. T2 - Sarcoidosis and chronic graft-versus-host disease after allogeneic stem cell transplant. AU - Manalo, Iviensan F.. AU - Miller, India Ashton. AU - Davis, Loretta S. PY - 2016/3/1. Y1 - 2016/3/1. KW - Allogeneic hematopoietic stem cell transplant. KW - Chronic graft-versus-host disease. KW - Cutaneous manifestations of systemic disease. KW - Cutaneous sarcoidosis. KW - Graft-versus-host-disease. KW - Granulomatous dermatitis. KW - Human leukocyte antigen. KW - Noncaseating granulomas. KW - Sarcoidosis. UR - http://www.scopus.com/inward/record.url?scp=84960876408&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=84960876408&partnerID=8YFLogxK. U2 - 10.1016/j.jdcr.2016.01.008. DO - 10.1016/j.jdcr.2016.01.008. M3 - Article. AN - SCOPUS:84960876408. VL - 2. SP - 138. EP - 140. JO - JAAD Case Reports. JF - JAAD Case Reports. SN - 2352-5126. IS - 2. ER - ...
The impact of ABO incompatibility on hematopoietic stem cell transplantation (HSCT) outcome is controversial. As ABH substances are expressed on tissues and secreted in body fluids, they could drive an immune response in minor ABO-incompatible HSCT. The aim of the study was to investigate the prognostic role of the recipients ABH secretor status.; Patients who underwent minor ABO-incompatible HSCT were included. Secretor status was determined either serologically or by molecular genetics.; Between March 1996 and June 2012, a total of 176 patients received minor ABO-incompatible HSCT and 150 (85%) were secretors. Incidence and severity of acute graft-versus-host disease (GVHD) and chronic GVHD did not differ between secretors and nonsecretors (cumulative incidences ± standard errors: acute GVHD on Day 100, 41 ± 11 and 46 ± 5%, p = 0.59; chronic GVHD at 2 years, 52 ± 13 and 56 ± 5%, p = 0.62, for secretors and nonsecretors, respectively). Additionally, nonrelapse mortality ...
OBJECTIVE: To assess the effect of azithromycin mass drug administration regimens on spleen rates in children aged 0-5 years.,br/, METHODS: Clinical assessment of spleen size was carried out during a cluster-randomised trial of azithromycin mass treatment for trachoma elimination in The Gambia. Twenty-four communities received three annual mass treatments with azithromycin, and 24 communities received treatment at baseline only.,br/, RESULTS: At the 30-month follow-up, 3646 children aged 0-5 years had spleen examination and measurement. Palpable splenomegaly was significantly lower in annually treated vs. baseline-only treatment communities and in treated vs. untreated children at 24 months in the annual treatment arm.,br/, CONCLUSION: The results suggest an effect of azithromycin on spleen rates at the individual level and are most plausibly due to the antimalarial effects of azithromycin.,br/, ...
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TY - JOUR. T1 - Prognostic value of FDG-PET prior to autologous stem cell transplantation for relapsed and refractory diffuse large B-cell lymphoma. AU - Sauter, Craig S.. AU - Matasar, Matthew J.. AU - Meikle, Jessica. AU - Schoder, Heiko. AU - Ulaner, Gary A.. AU - Migliacci, Jocelyn C.. AU - Hilden, Patrick. AU - Devlin, Sean M.. AU - Zelenetz, Andrew D.. AU - Moskowitz, Craig. PY - 2015/4/16. Y1 - 2015/4/16. N2 - High-dose chemotherapy (HDT) plus autologous stem cell transplantation (ASCT) is the standard of care for chemosensitive relapsed and refractory diffuse large B-cell lymphoma (rel/ref DLBCL). Interim restaging with functional imaging by positron emission tomography using 18F-deoxyglucose (FDG-PET) has not been established after salvage chemotherapy (ST) and before HDT-ASCT by modern criteria. Herein, we evaluated 129 patients with rel/ref DLBCL proceeding to HDT-ASCT, with ST response assessment ...
Reduced intensity conditioning (RIC) regimens have allowed older patients and those with comorbidities to receive hematopoietic cell transplantation (HCT). We analyzed medical costs from the beginning of conditioning to 100 days after HCT for 484 patients and up to 2 years for 311 patients who underwent a RIC HCT at two institutions from January 2008 to December 2010. Multiple linear regression was used to analyze the association between clinical variables, center effect, and costs. Patient and transplant characteristics were comparable between the sites, although differences were seen in pretransplant performance scores. Significant predictors for lower costs for the first 100 days included a diagnosis of lymphoma/myeloma and use of human leukocyte antigen-matched related donors. Grade II-IV acute graft-versus-host disease (GVHD) was associated with higher costs. The overall short-term costs between the two institutions were comparable when adjusted for clinical variables ...
Results Twenty-five patients developed hemorrhagic cystitis. Pre-transplant BK viruria detected by quantitative PCR was positive in 96 patients. The one-year cumulative incidence of hemorrhagic cystitis was 16% in the PCR-positive group versus 9% in the PCR-negative group (P=0.1). The use of umbilical cord blood or a haploidentical donor was the only significant predictor of the incidence of hemorrhagic cystitis on univariate analysis. There was also a trend for a higher incidence after myeloablative conditioning. Multivariate analysis showed that patients who had a positive PCR pre-transplant and received haploidentical or cord blood grafts with myeloablative conditioning had a significantly higher risk of developing hemorrhagic cystitis (58%) than all other recipients (7%, P,0.001). ...
With the expression "bone marrow hematopoietic stem cell transplant" we intend a complex procedure used especially, but not only, in the treatment of leukimias and lymphomas. Stem cells can be obtained not only from bone marrow but also from peripheral blood after a specific preconditioning of the patient, or from umbilical-cord blood.. Indications for hematopoietic stem cell transplant are acute leukimias, chronic leukimias, different forms of bone marrow insufficiency, thalassemias, Hodgkin lymphoma, non Hodgkin lymphomas, myelomas, other chronic myeloproliferative diseases, numerous genetic disorders and, as a recent indication, some autoimmune illnesses.. ...
Pediatric anaplastic large cell lymphoma (ALCL) is a chemosensitive malignancy, but about 30% of patients experience relapse. In most of these patients, a second complete remission is obtainable with salvage chemotherapy, though relapse free survival rates are as low as 30-60%. Herein, we report a 6-year-old boy with relapsed anaplastic lymphoma kinase (ALK) positive ALCL successfully treated with vinblastine monotherapy followed by allogeneic hematopoietic stem cell transplantation (allo-HSCT), with a reduced intensity conditioning (RIC) regimen, from his father. One HLA locus from the father was mismatched. The boy had neither severe graft-versus-host disease nor transplantation related complications. He is currently well and has remained disease free for 10 months, to date, since transplantation. Allo-HSCT with a RIC regimen may be a promising treatment strategy for relapsed ALK positive ALCL based on obtaining ...
Purpose: : To describe the outcome of penetrating keratoplasty (PKP) in patients who had previously undergone cultivated limbal stem cell transplantation. Methods: : Medical records of patients with limbal stem cell deficiency who underwent PKP after cultivated limbal stem cell transplantation were reviewed for demographics, primary etiology, type of surgical procedure, best corrected visual acuity, ocular surface conditions and complications. Results: : Thirty-eight patients with limbal stem cell deficiency underwent PKP at a mean interval of 23.5 months (range: 6-92 months) following cultivated limbal stem cell transplantation. Twenty-one patients (55.3%) underwent PKP, 17 patients (44.7%) PKP combined with cataract extraction. Preoperative best-corrected visual acuity was less than 1/10 in 29 of the 38 eyes (76.3%). At a mean follow-up of 27.5 months (range: 1-92 months) ...
Inherited bone marrow failure (IBMF) syndromes are a heterogeneous group of rare hematological disorders characterized by the impairment of hematopoiesis, which harbor specific clinical presentations and pathogenic mechanisms. Some of these syndromes may progress through clonal evolution, myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). Most prominent are failures of DNA repair such as Fanconi Anemia and much rarer failure of ribosomal apparatus, e.g., Diamond Blackfan Anemia or...
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Limiting dilution analyses with the Poisson model were performed on normal mouse spleen cells alone or in the presence of added cells or soluble factors. When a constant number of T cells activated to sheep red blood cells were added to cultures of diluted spleen cells the mean frequency of response to sheep red blood cells was 5- to 30-fold greater than that of spleen cells diluted alone. Adding a constant number of B cells did not produce a significant change in the mean frequency of response of diluted spleen cells. Since a responding unit is thought to be composed of T cells and B cells, these results indicate that antigen-specific T cells normally limit the generation of responding units when normal spleen ...
I am Associate Professor of Hematology/ Bone Marrow Transplantation in Medical School of University of Patras/ Greece and Clinical Program Director of the Bone Marrow Transplantation and Leukemia Program at Patras University Hospital. I am German Board Certified in Internal Medicine, Hematology and Oncology. I have been working in the field of medical oncology and hematology for ten years in Germany and for the past seven years in Greece. After completing my medical studies in Greece, I moved (1995-2005) to the Dept. of Hematology/Oncology of Freiburg University / Germany (Dir. Prof. R. Mertelsmann), where I completed my PhD Thesis on hematopoietic stem cell biology and engineering, my internal medicine training, my hematology and oncology training and a specialist training in Hematopoietic Stem Cell Transplantation (HSCT). I have been given the Venia Legendi (Assistant Professorship) of the University of Freiburg in 2004. ...
Spleen disorders are mainly a danger when left unaddressed. Although you can survive having you spleen removed (called a splenectomy), you might not be able to survive the causes of spleen disorders. That is why it is important to make an appointment with your doctor if you feel you may have a spleen condition. The purpose and function of the spleen. The spleen is a bodily organ that rests in the left side of the abdominal cavity, between the 9th to 12th ribs. The spleens central purpose is to get rid of old red blood cells, although it also functions as reservoir for blood in case you suddenly need it due to some sort of trauma.
TY - JOUR. T1 - Haematopoietic stem cell mobilization with plerixafor and G-CSF in patients with multiple myeloma transplanted with autologous stem cells. AU - Basak, Grzegorz W.. AU - Jaksic, Ozren. AU - Koristek, Zdenek. AU - Mikala, Gabor. AU - Basic-Kinda, Sandra. AU - Mayer, Jiri. AU - Masszi, Tamas. AU - Giebel, Sebastian. AU - Labar, Boris. AU - Wiktor-Jedrzejczak, Wieslaw. PY - 2011/6/1. Y1 - 2011/6/1. N2 - A proportion of patients with multiple myeloma (MM) who have already undergone autologous stem cell transplantation (autoSCT) might benefit from a further transplantation. For this, they might need to undergo another round of stem cell mobilization. We analyzed retrospectively the outcomes of stem cell mobilization with plerixafor and granulocyte colony-stimulating factor (G-CSF) in a group of 30 patients who had undergone autoSCT previously, and in 46 other patients. The ...
Mugraby, L; Gery, I; and Sulitzeanu, D, "Subpopulations of mouse spleen lymphocytes. Iii. Cellular inter- actions in the response to concanavalin a." (1975). Subject Strain Bibliography 1975. 1761 ...
Karpf, M; Gelfand, M C.; Handwerger, B S.; and Schwartz, R H., "Lack of b lymphocyte depletion from murine spleen cell populations by a human gamma-globulin, anti-human gamma-globulin column system." (1975). Subject Strain Bibliography 1975. 1248 ...
In the Netherlands, allogeneic HSCT using cord blood from an unrelated donor is covered by health insurance. Due to the novelty, the treatment is being offered in the form of a clinical trial. The trial has been open as of March 1st 2016 in the University Medical Centre Groningen and Wilhelmina Childrens Hospital of the University Medical Centre Utrecht. The rate for intake and transplantation is limited to one patient per two months. We aim to treat 10 patients. Eligible patient are those with severe generalized recessive dystrophic epidermolysis bullosa (preferably complete absence of type VII collagen), an age between 0-18 years, and be willing to visit Groningen and Utrecht regularly for 2 years. The hospitalization period is on average 8 weeks but may be longer. Patients from the European Union need an E-112 form approved by their national health insurance to cover hospital costs in the Netherlands. Parents can rent a room in the Ronald McDonald House or find a rental apartment with our ...
The relative functional maturity of neonatal mouse spleen T- and B-cell populations was assessed by comparing the ability to respond to the thymic-independent antigen, DNP-Ficoll, or thymic-dependent SRBC by producing antibody in vitro. Although mouse spleen cells responded to DNP-Ficoll at an earlier age than they responded to SRBC or TNP-SRBC, the reason for the lag in the T-dependent response was confounded by the finding of high numbers of suppressor T lymphocytes in the neonatal spleen. Thus, small numbers of neonatal spleen T cells or thymocytes significantly decreased the in vitro antibody response of adult spleen cells. Although B lymphocytes appear to be functionally mature soon after birth, their acitivity may be modulated by an excess of suppressor T cells; e.g., the reconstitution of helper cell function in the ...
The Spleen has a wide range of functions, from digestion to muscle tone to sensuality. The Spleen manufactures Qi from our food. The Spleens role is to transform and move foods, liquids, and thoughts in the body (i.e. digestion). For this reason the Spleen is called the source of postnatal energy (acquired Qi). It has a primary role in the lymphatic and immune systems. It keeps our tissues, muscles, and thoughts moist, supple, adaptable. The Spleen governs taste and true nourishment. It regulates bio-rhythms including menstruation. The Spleen stores Yi, consciousness of potentials, the ability to focus the mind sharply and keenly. A healthy spleen requires a stabile home environment. The Spleen harmonizes upper and lower parts of the body. Worry and over-thinking are the greatest causes of Spleen depletion.. The Spleen is the largest ...
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White pulp is a histological region of the spleen. The altered coat of the arterioles, consisting of adenoid tissue, presents here and there thickenings of a spheroidal shape, the white pulp (Malpighian bodies of the spleen, splenic lymphoid nodules). These bodies vary in size from about 0.25 mm. to 1 mm. in diameter. They are merely local expansions or hyperplasia of the adenoid tissue, of which the external coat of the smaller arteries of the spleen is formed. They are most frequently found surrounding the arteriole, which thus seems to tunnel them, but occasionally they grow from one side of the vessel only, and present the appearance of a sessile bud growing from the arterial wall. There are several parts of white pulp with distinct functions: Periarteriolar lymphoid sheaths (PALS) are typically associated with the arteriole supply of the spleen; contain T lymphocytes. Lymph follicles with dividing B lymphocytes are located between PALS ...
To the best of our knowledge, this is the first report of the use of biosimilar G-CSF for the mobilization of PBSC in children committed to autologous transplantation. Biosimilar G-CSF is a cheaper alternative to originator molecule filgrastim. The patent for filgrastim expired in Europe in 2006 and in the United States in 2013. European Medicines Agency has approved several biosimilar versions, three of which are commercially available.[9] Yet, concerns have been raised in 2011 among hematologists on the use of biosimilar G-CSF in stem cell transplant, until sufficient efficacy and safety data are available.[10] The first report of the use of a biosimilar G-CSF for stem cell mobilization for autologous transplantation was published by Lefrère and colleagues in 2011,[11] in whom 40 patients achieved similar mobilization yield and safety profile to the originator G-CSF. Moreover, the biosimilar G-CSF-mobilized cells were able ...
In patients with Hodgkin lymphoma who are at risk for disease progression following autologous stem cell transplantation, early consolidation with brentuximab vedotin (Adcetris) post-transplant significantly improved progression-free survival compared with placebo in the phase III AETHERA trial.1 The median progression-free survival was 43 months for the brentuximab-treated group vs 24 months for the placebo group, representing a significant 43% reduction in the risk of disease progression (P = .001).. "In my opinion, once this study is published, brentuximab should be the standard of care for patients with the characteristics in this trial: that is, remission duration less than 1 year, extranodal disease, B symptoms, two or more prior salvage therapies, and primary refractory disease," said lead author Craig Moskowitz, MD, Clinical Director of the Division of Hematologic Oncology at Memorial Sloan Kettering Cancer Center, New York.. Dr. Moskowitz explained that autologous ...
The intoxication which is developed when splenectomized mice are fed with fresh spleen is more regular in occurrence when the feeding experiment is carried out four or five days after splenectomy than when it is done at later periods. The intoxication is easily recognizable even in its less severe forms by a lengthening of the coagulation time of the blood.. An intoxication of the same character is produced when splenectomized mice are fed with the mucous membrane of the stomach and upper small intestine. Bone marrow and dried blood probably give the same reaction in a somewhat milder form. The other organs either give no intoxication at all when fed, or in certain instances the thyroid, adrenal, and salivary gland (mouse) give intoxications of a different character which affect intact mice and splenectomized animals equally.. The spleen or the gastro-intestinal mucosa is equally effective in producing the intoxication, whether it be derived from heterologous or ...
You will be placed under general anaesthesia and be completely asleep. A cannula (hollow tube) is placed into the abdomen by your surgeon and your abdomen will be inflated with carbon dioxide gas to create a space to operate. A laparoscope (a tiny telescope connected to a video camera) is put through one of the cannulas which projects a video picture of the internal organs and spleen on a television monitor. Several cannulas are placed in different locations on your abdomen to allow your surgeon to place instruments inside your belly to work and remove your spleen. A search for accessory (additional) spleens and then removal of these extra spleens will be done since 15% of people have small, extra spleens. After the spleen is cut from all that it is connected to, it is placed inside a special bag. The bag with the spleen inside is pulled up into one of the small, but largest incisions on ...
I dont know about spleen, but I think Ill have to try out that neatloaf recipe. Of course, pig spleen could be another good gluten-free alternative to Special K for all we know, but then it would no longer be vegetarian. Ill just assume pig spleen is a better weather predictor than dinner ingredient and stick with the recipe as it is for now. ...
Da Fonseca received his dental degree at the Federal University of Juiz de Fora, Brazil, in 1987. He went on to the University of Minnesota, for his Master of Science degree and certificate in Pediatric Dentistry, followed by a fellowship at the Denver Childrens Hospital. In 1994-95, he did an Oral Medicine fellowship at the Fred Hutchinson Cancer Research Center in Seattle working exclusively with hematopoietic stem cell transplant children. He was a clinical assistant professor and director of undergraduate pediatric dentistry at the University of California, San Francisco (1995-97). At the University of Michigan, Ann Arbor (1997 to 2005), he was director of the pediatric dental service at the University Medical Center. He was director of inpatient dental care at Nationwide Childrens Hospital and a clinical professor at the Ohio State University College of Dentistry (2005-2010) in Columbus. He is currently Law-Lewis Professor and director of the pediatric dental graduate program at the ...
The purpose of this report is to describe the results of stem cell transplantation as initial treatment for secondary acute myeloid leukemia (AML). Forty-six patients (median age 42 years) with secondary AML (17 therapy-related, 29 myelodysplasia-related) who had not received remission induction chemotherapy underwent allogeneic (n = 43) or syngeneic (n = 3) transplantation. The 5-year actuarial disease-free survival was 24.4%, and the cumulative incidences of relapse and nonrelapse mortality were 31.3% and 44.3%, respectively. Lower peripheral blood blast count was associated with a lower risk of relapse (P = .05) and shorter time from AML diagnosis to transplant was associated with a lower risk of nonrelapse mortality (P = .02) and improved disease-free survival (P = .026). Patients with therapy-related secondary AML tended to have lower disease-free survival (P = .16) and a higher relapse rate (P = .16) than patients whose leukemia was not ...
The spleen sits under your rib cage in the upper left part of your abdomen toward your back. It is an organ that is part of the lymph system and works as a drainage network that defends your body against infection. White blood cells produced in the spleen engulf bacteria, dead tissue, and foreign matter, removing them from the blood as blood passes through it. The spleen also maintains healthy red and white blood cells and platelets; platelets help your blood clot. The spleen filters blood, removing abnormal blood cells from the bloodstream. A spleen is normally about the size of your fist. A doctor usually cant feel it during an exam. But diseases can cause it to swell and become many times its normal size. Because the spleen is involved in many functions, many conditions may affect it. An enlarged spleen is not always a sign of a problem. ...
The spleen cells isolated from SCID mice transplanted with human tonsillar lymphocytes(Hu- TLC-SCID)immunized with dengue virus 2 type(DV_2)in vitro and in vivo were trans-formed by Epstein-Barr virus(EBV).Specific human anti-DV_2 antibodies were detectable in thesupernatant of the transfomed spleen cells.The presence of human B lymphocyte markers(and SmIgG) as well as EBV antigens (LMP1 and BENA)and LMP1 gene fragment in the trans-formed spleen cells determined by immunoperoxidase staining immunofluorescence technique andPCR technique,indicated that the Hu-TLC-SCID mouse spleen cell has been successfully trans-foimed by EBV.The EBV-transformed Hu-TLC-SCID mouse spleen cell could be utilized forcontinous production of specific human anti-DV_2 antibodies in vitro.
Post-transplant lymphoproliferative disorder (also known as PTLD) is defined as a lymphoid (immune cells) and/or plasmacytic proliferations (rapid increase) due to therapeutic immunosuppression after organ transplantation especially in the patients who are undergoing solid organ or allogeneic (donor) hematopoietic stem cell transplantation. Post transplant lymphoproliferative disorder was first discovered by Denis Parsons Burkitt, an Irish physician, in 1965. According to World Health Organization (WHO) classification system, post transplant lymphoproliferative disorder may be classified into 4 subtypes: early hyperplastic lesions, polymorphic lesions, monomorphic lesions, and classic Hodgkin-type lymphomas. Patients with post-transplant lymphoproliferative disorder may develop serious complications of transplantation with infectious mononucleosis-like lesions due to Epstein-Barr virus (EBV) or polyclonal polymorphic ...
TY - JOUR. T1 - Assessing donor chimerism using flow cytometry in paroxysmal nocturnal haemoglobinuria after stem cell transplantation--a case report.. AU - Raja Sabudin, Raja Zahratul Azma. AU - Hussin, Noor Hamidah. AU - Chooi Fun, Leong. AU - Ainoon, O.. AU - Cheong, S. K.. PY - 2006/12. Y1 - 2006/12. N2 - Paroxysmal nocturnal haemoglobinuria (PNH) is an acquired haemopoietic stem cell disorder arising from somatic mutation of the X-linked PIG-A gene which leads to deficiency of the glycosylphosphatidylinositol (GP1) membrane anchor proteins such as CD 59 (MIRL: membrane inhibitor of reactive lysis) and CD 55 (DAF: decay accelerating factor). Allogeneic peripheral blood stem cell transplant (PBSCT) is a curative mode of treatment in symptomatic PNH patients. Assessment of donor chimerism for PBSCT can be performed by various methods including short tandem repeat loci (STR) and variable number of tandem repeats (VNTR). Flow cytometry, ...
OBJECTIVE We examined the therapeutic strategies for treating mild gastrointestinal (GI) graft-versus-host disease (GVHD) using oral beclomethasone dipropionate (BDP) in 15 Japanese patients based on the donor source. The primary objective was to determine the efficacy and toxicity of oral BDP combined with/without low-dose prednisone (PSL). METHODS Oral BDP was administered with 1 mg/kg/d of PSL in patients undergoing bone marrow transplantation (BMT) or peripheral blood stem cell transplantation (PBSCT; n=11), and the dose of PSL was tapered off after 22 days. Oral BDP alone was administered in patients undergoing cord blood stem cell transplantation (CBSCT; n=4). The primary endpoint was the rate of treatment success on day 49, as measured according to the improvement or complete resolution of GI symptoms without additional treatment. The secondary endpoints included treatment-related toxicity according to the National ...
TY - JOUR. T1 - Inactivated varicella zoster vaccine in autologous haemopoietic stem-cell transplant recipients. T2 - an international, multicentre, randomised, double-blind, placebo-controlled trial. AU - V212 Protocol 001 Trial Team. AU - Winston, Drew J.. AU - Mullane, Kathleen M.. AU - Cornely, Oliver A.. AU - Boeckh, Michael J.. AU - Brown, Janice Wes. AU - Pergam, Steven A.. AU - Trociukas, Igoris. AU - Žák, Pavel. AU - Craig, Michael D.. AU - Papanicolaou, Genovefa A.. AU - Velez, Juan D.. AU - Panse, Jens. AU - Hurtado, Kimberly. AU - Fernsler, Doreen A.. AU - Stek, Jon E.. AU - Pang, Lei. AU - Su, Shu Chih. AU - Zhao, Yanli. AU - Chan, Ivan S.F.. AU - Kaplan, Susan S.. AU - Parrino, Janie. AU - Lee, Ingi. AU - Popmihajlov, Zoran. AU - Annunziato, Paula W.. AU - Arvin, Ann. AU - Basso, A. C.. AU - Bonvehi, P.. AU - Cerana, S.. AU - Dictar, M. O.. AU - Campbell, P.. AU - Playford, G.. AU - Sasadeusz, J.. AU - Maertens, J.. AU - Poire, X.. AU - Sellesag, D.. AU - ...
Toll-like receptors (TLRs) play a key role in B cell-mediated innate and adaptive immunity. It has been shown that interleukin 10 (IL-10)-producing regulatory B cells (B10 cells) can negatively regulate cellular immune responses and inflammation in autoimmune diseases. In this study, we determined the effect of TLR4 signaling on the CD40-activated B10 cell competency. The results demonstrated that LPS and CD40L synergistically stimulated proliferation of mouse splenocytes. The percentage of B10 cells in cultured splenocytes was significantly increased after CD40L stimulation but such increase was diminished by the addition of LPS. Such effects by LPS were only observed in cells from WT but not TLR4−/− mice. IL-10 mRNA expression and protein production in B10 cells from cultured splenocytes were significantly up-regulated by CD40L stimulation but were inhibited after the ...
Flowers, ME, Inamoto, Y, Carpenter, PA. "Comparative analysis of risk factors for acute graft-versus-host disease and for chronic graft-versus-host disease according to National Institutes of Health consensus criteria". . vol. 117. 2011. pp. 3214-9. (Multiple studies in the 1990s evaluated risk factors for acute GVHD. This recently published large study from a single center confirmed and extended prior observations. Of note, recipient age was not a statistically significant risk in this study.). Jagasia, M, Arora, M, Flowers, ME. "Risk factors for acute GVHD and survival after hematopoietic cell transplantation". Blood. vol. 119. 2012. pp. 296-307. (Analysis of over 5000 related and unrelated donor transplants defined risk factors for acute GVHD.). Rühl, H, Bein, G, Sachs, UJ. "Transfusion-associated graft-versus-host disease". . vol. 23. 2009. pp. 62-71. (Excellent review of settings in which GVHD can develop, other than allogeneic bone marrow ...
Background.Invasive pneumococcal disease is a life-threatening complication after allogeneic stem cell transplantation, and at least 20% of cases occur within 1 year after transplantation. The 23-valent pneumococcal polysaccharide vaccine (PPV23) has limited efficacy, especially during the first year after transplantation. The immune response to the conjugated vaccines is expected to be better than that to the polysaccharide vaccine, but the optimal timing of vaccination is not defined. Our objective was to show that a 7-valent pneumococcal conjugate vaccine (PCV7; Prevnar) was not inferior when first given 3 months after transplantation, compared with when first given 9 months after transplantation.. Methods.We performed a multicenter, randomized, noninferiority study involving 158 patients from 13 European Group for Blood and Marrow Transplantation centers who were randomly allocated at ...
In French, spleen refers to a state of pensive sadness or melancholy. It has been popularized by the poet Charles Baudelaire (1821-1867) but was already used before, in particular in the Romantic literature (18th century). The connection between spleen (the organ) and melancholy (the temperament) comes from the humoral medicine of the ancient Greeks. One of the humours (body fluid) was the black bile, secreted by the spleen organ and associated with melancholy. In contrast, the Talmud (tractate Berachoth 61b) refers to the spleen as the organ of laughter, possibly suggesting a link with the humoral view of the organ. In German, the word "spleen", pronounced as in English, refers to a persisting somewhat eccentric (but not quite lunatic) idea or habit of a person; however the organ is called "Milz", (cognate with Old English milte). In 19th century England women in bad humour were said to be afflicted by ...
Visceral leishmaniasis is associated with architectural disorganization of the splenic tissue in human and in dogs. In this study we estimate the changes in the number of Ki-67+ (proliferating cells), CD3+ (T cells), α-CD79+ (cells B) and S100+ (follicular dendritic cells) and in the expression of CXCL13, LTα, TNF, IFN-gamma, IL10, TGFbeta, CCR7, CCL19, CCL21 in the spleens of dogs from an endemic area of visceral leishmaniasis, with organized or disorganized splenic architecture. The number of T cells, B cells, proliferating cells and follicular dendritic cells was lower in the lymphoid follicle of the animals with disorganized splenic tissue than in animals with organized splenic tissue (P , 0.01). The number of B cells was also reduced in the MZ of animals with disorganized splenic tissue (P , 0.01). B cells (P , 0.01) ...
Background. Respiratory syncytial virus (RSV) can be fatal in immunocompromised patients. Aerosolized ribavirin is used for treatment but it is costly, teratogenic, and inconvenient. We aimed to assess the outcome of oral ribavirin, with or without intravenous immunoglobulin (IVIG) for RSV in immunocompromised patients.. Methods. The medical records of moderate to severely immunocompromised patients with RSV infection in 2011-12 were reviewed. Severely immunocompromised patients were defined as (1) allogenic hematopoietic stem cell transplant (HSCT) patients ,6 months after transplantation or beyond 6 months with ,grade 2 GVHD and (2) lung recipients in the first year post-transplant or beyond one year with augmented immunosuppression. Moderately immunocompromised patients were (1) other solid organ transplant recipients, (2) patients with hematologic malignancies receiving chemotherapy, (3) allogenic HSCT patients ,6 months after HSCT or with GVHD ,grade 2, (4) autologous ...
Cell dose is a critical determinant of outcomes in unrelated cord blood (CB) transplantation. We investigated a strategy in which CB units should contain at least 2 × 107 total nucleated cells/kg of recipient weight, otherwise a second unit had to be added. We report the results of a study that was prematurely closed owing to toxicity. Patients with advanced hematologic malignancies without a human leukocyte antigen-matched sibling or unrelated donor were eligible. Conditioning regimen consisted of fludarabine and 12 Gy of total body irradiation (n=11), or melphalan (n=4), with antithymocyte globulin. Graft-versus-host disease prophylaxis was tacrolimus and methotrexate. Fifteen patients with acute leukemia (n=9), chronic myelogenous leukemia (n=2), multiple myeloma (n=2) and lymphoma (n=2) were treated; 60% had relapsed disease at transplantation. Three patients received double CB transplants. The 100-day and 1-year treatment-related ...
TY - JOUR. T1 - Haematopoietic stem cells and early lymphoid progenitors occupy distinct bone marrow niches. AU - Ding, Lei. AU - Morrison, Sean J.. PY - 2013/3/14. Y1 - 2013/3/14. N2 - Although haematopoietic stem cells (HSCs) are commonly assumed to reside within a specialized microenvironment, or niche, most published experimental manipulations of the HSC niche have affected the function of diverse restricted progenitors. This raises the fundamental question of whether HSCs and restricted progenitors reside within distinct, specialized niches or whether they share a common niche. Here we assess the physiological sources of the chemokine CXCL12 for HSC and restricted progenitor maintenance. Cxcl12DsRed knock-in mice (DsRed-Express2 recombined into the Cxcl12 locus) showed that Cxcl12 was primarily expressed by perivascular stromal cells and, at lower levels, by endothelial cells, osteoblasts and some haematopoietic cells. ...
Leukodystrophies (LD) are devastating inherited disorders leading to rapid neurological deterioration and premature death. Hematopoietic stem cell transplantation (HSCT) can halt disease progression for selected LD. Cord blood is a common donor source for transplantation of these patients because it is rapidly available and can be used without full HLA matching. However, precise recommendations allowing care providers to identify patients who benefit from HSCT are lacking. In this study, we define risk factors and describe the early and late outcomes of 169 patients with globoid cell leukodystrophy, X-linked adrenoleukodystrophy, and metachromatic leukodystrophy undergoing cord blood transplantation (CBT) at an European Society for Blood and Marrow Transplantation center or at Duke University Medical Center from 1996 to 2013. Factors associated with higher overall survival (OS) included presymptomatic status ...
Urea effect on mice spleen cells - posted in Protein Expression and Purification: Hi, I am going to do lymphocyte proliferation assay using mouse spleen cells in order to assess the cytokine profile of the cells (IFN-gamma, IL-2 and IL-10) after induction with the target protein. I have purified my recombinant protein of interest using denaturing method by 6M Urea. Since my protein disappears after dialysis, I wondered if I could use the protein for inducing cells without dialysis. I would...
Bronchiolitis obliterans (BO) is a disease with a poor prognosis, and a key factor that limits long-term survival after allogeneic hematopoietic stem cell transplantation (HSCT). We here report a case of a 31-year woman with acute lymphatic leukemia, which was treated by chemotherapy and HSCT, and consequently developed BO 2 years after HSCT. A non-tuberculous mycobacterial infection occurred and showed gradual exacerbation. She started taking anti-mycobacterial drugs, but lost appetite, felt tired and finally lost consciousness one month after beginning medication. Arterial blood gas revealed marked hypercapnia. Using extracorporeal life support (ECLS), the carbon dioxide concentration was reduced and her consciousness recovered. To our knowledge, this is the first case in which ECLS was successfully used for hypercapnia in a patient with BO ...
Wnt signaling increases hematopoietic stem cell self-renewal and is activated in both myeloid and lymphoid malignancies, indicating involvement in both normal and malignant hematopoiesis. We report here activated canonical Wnt signaling in the hematopoietic system through conditional expression of a stable form of beta-catenin. This enforced expression led to hematopoietic failure associated with loss of myeloid lineage commitment at the granulocyte-macrophage progenitor stage; blocked erythrocyte differentiation; disruption of lymphoid development; and loss of repopulating stem cell activity. Loss of hematopoietic stem cell function was associated with decreased expression of Cdkn1a ( encoding the cell cycle inhibitor p21(cdk)), Sfpi1, Hoxb4 and Bmi1 ( encoding the transcription factors PU.1, HoxB4 and Bmi-1, respectively) and altered integrin expression in Lin(-)Sca-1(+)c-Kit(+) cells, whereas PU.1 was upregulated in ...
TY - JOUR. T1 - Primitive adult hematopoietic stem cells can function as osteoblast precursors. AU - Olmsted-Davis, Elizabeth A.. AU - Gugala, Zbigniew. AU - Camargo, Fernando. AU - Gannon, Francis H.. AU - Jackson, KathyJo. AU - Kienstra, Kirsten Anderson. AU - Shine, H. David. AU - Lindsey, Ronald. AU - Hirschi, Karen K.. AU - Goodell, Margaret A.. AU - Brenner, Malcolm K.. AU - Davis, Alan R.. PY - 2003/12/23. Y1 - 2003/12/23. N2 - Osteoblasts are continually recruited from stem cell pools to maintain bone. Although their immediate precursor is a plastic-adherent mesenchymal stem cell able to generate tissues other than bone, increasing evidence suggests the existence of a more primitive cell that can differentiate to both hematopoietic and mesenchymal cells. We show here that the "side population" (SP) of marrow stem cells, defined by their ability to rapidly expel a DNA-binding dye and to regenerate the ...
According to an analysis reported by Amanda Phipps, PhD, MPH, Assistant Professor of Epidemiology at the University of Washington and Assistant Member at Fred Hutchinson Cancer Research Center, Seattle, and colleagues in the Journal of Clinical Oncology, patients with stage III colon cancer who ever smoked had significantly reduced disease-free survival compared with never-smokers.1 The association between smoking and reduced disease-free survival was most marked in patients with BRAF wild-type or KRAS mutant colon cancer. Prior studies have indicated that cigarette smoking is associated with a modestly increased risk for colon cancer, particularly after long durations or high levels of exposure.. Study Details. The study involved 1,968 patients with stage III disease from the North Central Cancer Treatment Group phase III trial N0147 examining FOLFOX (infusional fluorouracil, leucovorin, and oxaliplatin) vs FOLFOX plus cetuximab (Erbitux) as adjuvant therapy. Questionnaires regarding smoking ...
PHILADELPHIA - New findings published in Cancer Epidemiology, Biomarkers & Prevention, a journal of the American Association for Cancer Research, confirm the risk of breast cancer among women who are obese and not physically active, and suggests additional mechanisms beyond estrogen.. Scientists from the Womens Health Initiative have found a relationship between obesity, physical activity and triple-negative breast cancer, a subtype of breast cancer characterized by a lack of estrogen, progesterone and HER2 expression. Triple-negative breast cancers account for about 10 to 20 percent of all breast cancers and are associated with an extremely poor prognosis due to a lack of targeted drug therapies.. "Breast cancer is not just one disease. It is a complex combination of many diseases," said Amanda Phipps, Ph.D., a postdoctoral fellow at the Fred Hutchinson Cancer Research Center. "The fact that we found an association with triple-negative breast cancer is unique because, biologically, this ...
The objective of this study was to evaluate the clinical features, prognostic factors, and efficacy of treatments in patients with blastic plasmacytoid dendritic cell neoplasm with a leukemic presentation at onset of the disease. In order to do this, a retrospective multicenter study was performed from 2005-2011 in 28 Italian hematology divisions in which 43 cases were collected. Forty-one patients received an induction therapy, consisting of an acute myeloid leukemia-type regimen in 26 patients (60%) and acute lymphoid leukemia/lymphoma-type regimen in 15 patients (35%). Six patients (14%) underwent allogeneic hematopoietic stem cell transplantation. Seventeen patients (41%) achieved a complete remission: seven after acute myeloid leukemia-type treatment and 10 after an acute lymphoid leukemia/lymphoma-type regimen, with a significant advantage for acute lymphoid leukemia/lymphoma-type chemotherapy (P=0.02). Relapse occurred in six of the 17 patients (35%) ...
The University of Washington Center for Child Environmental Health Risks Research (CHC) was established in 1998. The theme of the Center is understanding the biochemical, molecular, and exposure mechanisms that define childrens susceptibility to pesticides and the implications for assessing pesticide risks to normal development and learning. The CHC is a multidisciplinary research program that conducts basic and applied mechanistic research aimed at reducing the adverse effects of environmental pesticide exposures in children. The Centers research program includes basic mechanistic studies of toxicity, exposure assessment, risk assessment, and community-based participatory research. Researchers from the University of Washington (UW) and the Fred Hutchinson Cancer Research Center work in the laboratory, field, and community to bring a unique and successful approach to the study of childrens environmental health. It is administratively housed within the Institute for Risk Analysis and Risk ...
Adult T-cell leukemia/lymphoma (ATLL) is a peripheral T-cell lymphoma caused by human T-cell leukemia/lymphoma virus type 1 (HTLV-1). ATLL occurs in approximately 3%-5% of HTLV-1 carriers during their lifetime and follows a heterogeneous clinical course. The Shimoyama classification has been frequently used for treatment decisions in ATLL patients, and antiviral therapy has been reportedly promising, particularly in patients with indolent type ATLL; however, the prognosis continues to be dismal for patients with aggressive-type ATLL. Recent efforts to improve treatment outcomes have been focused on the development of prognostic stratification and improved dosage, timing, and combination of therapeutic modalities, such as antiviral therapy, chemotherapy, allogeneic hematopoietic stem cell transplantation, and molecular targeted therapy.
Outcome after unrelated donor bone marrow (BM) transplantation for severe aplastic anemia (SAA) has improved, with survival rates now approximately 75%. Increasing use of peripheral blood stem and progenitor cells (PBPCs) instead of BM as a graft source prompted us to compare outcomes of PBPC and BM transplantation for SAA. We studied 296 patients receiving either BM (n = 225) or PBPC (n = 71) from unrelated donors matched at human leukocyte antigen-A, -B, -C, -DRB1. Hematopoietic recovery was similar after PBPC and BM transplantation.
National Marrow Donor Program News. Find breaking news, commentary, and archival information about National Marrow Donor Program From The tribunedigital-sunsentinel
It has been difficult to correlate the quality of CD8 T cell responses with protection against viral infections. To investigate the relationship between efficacy and magnitude of T cell responses, we quantify the rate at which individual CD8 effector and memory T cells kill target cells in the mouse spleen. Using mathematical modeling, we analyze recent data on the loss of target cells pulsed with three different peptides from the mouse lymphocytic choriomeningitis virus (LCMV) in mouse spleens with varying numbers of epitope-specific CD8 T cells. We find that the killing of targets follows the law of mass-action, i.e., the death rate of individual target cells remains proportional to the frequency (or the total number) of specific CD8 T cells in the spleen despite the fact that effector cell densities and ...
TY - JOUR. T1 - Concurrent acute necrotizing adenovirus hepatitis and enterocolitis in an adult patient after double cord blood stem cell transplant for refractory. AU - Disease, Crohns. AU - Lo, Amy A.. AU - Lo, Edward C.. AU - Rao, M. Sambasivia. AU - Yang, Guang Yu. PY - 2015/5/1. Y1 - 2015/5/1. N2 - It has been recently recognized that adenovirus is a pathogen with high morbidity and mortality among immunocompromised patients, particularly after solid organ or stem cell transplant. Confluent necrotizing hepatitis secondary to adenovirus infection alone or together with other organ involvement is extremely rare. There are only 32 cases of confluent necrotizing hepatitis reported in adults since 1960 and most occur after iatrogenic immunosuppression for bone marrow or solid organ transplantation or in other states of immunosuppression, including acquired immunodeficiency syndrome or chemotherapy treatment. We present the first case of concurrent ...
en] Purpose: Randomized trial LNH93-3 was conducted on patients who had poor-prognosis aggressive lymphoma and were younger than 60 years with two to three factors of the age-adjusted International Prognostic Index to evaluate the benefit of early high-dose therapy (HDT) with autologous stem-cell transplantation (ASCT). Patients and Methods: Patients were randomized between doxorubicin, cyclophosphamide, vindesine, bleomycin, and prednisone (ACVBP) chemotherapy followed by sequential consolidation and an experimental shortened treatment consisting of three cycles with escalated doses of cyclophosphamide, epirubicin, vindesine, bleomycin, and prednisone and collection of peripheral-blood stem cells. On day 60, HDT was administered with 1,3-bis(2-chloroethyl)-1-nitrosourea, etoposide, cytarabine, and melphalan followed by ASCT. Results: Eligible patients (n = 370) with aggressive lymphoma were analyzed. For ACVBP (181 patients) and HDT (189 patients), ...
Values are mean ± SD, n (%), or n/N.. EDV = end-diastolic volume; ESV = end-systolic volume; LA = left atrium; LS = lymphoma survivors; LV = left ventricle; RV = right ventricle; TAPSE = tricuspid annular plane systolic excursion.. ∗p , 0.01. The p values for comparisons in echocardiographic parameters between the LS and controls are derived from independent Student t tests; comparisons between treatment subgroups not performed. The p values for other comparisons between the LS and controls derived from chi-square test. The p values for comparisons between treatment subgroups in distribution of dysfunctional valves and valvular degeneration by chi-square test (†p , 0.05 compared with both other groups).. ...
Approximately 5-10% of diffuse large B-cell lymphomas (DLBCL) harbor a 8q24/MYC rearrangement (MYC+). We determined the prognostic significance of MYC rearrangement in patients with relapsed/refractory DLBCL prospectively treated by R-ICE or R-DHAP followed by highdose therapy and autologous stem cell transplantation. Twenty-eight (17%) of the 161 patients analyzed presented a MYC+ rearrangement, targeted as either simple hit (25%) or complex hits (n = 75%) including MYC/BCL2, MYC/BCL6, and MYC/BCL2/BCL6. Results were statistically highly concordant in matched primary and relapsed biopsies (n = 45). Compared to the MYC+ DLBCL patients, the MYC+ DLBCL patients presented with a more elevated lactico-deshydrogenase level (P = .0006) and a more advanced age adjusted international prognostic index (P = .0039). The 4-year PFS and OS were significantly lower in the MYC+ DLBCL patients than those in the MYC- DLBCL patients, with rates of 18% vs 42% (P = .0322), and ...
The Bone Marrow and Stem Cell Transplant Center at the UNM Comprehensive Cancer Center offers treatment choices for people with lymphoma and myeloma.Almost 1,000 New Mexicans receive a blood cancer diagnosis each year, according to American Cancer Society estimates.. The UNM Comprehensive Cancer Center program is the states only bone marrow transplant program.It includes a nurse manager, nurse coordinator, a social worker, a pharmacist, infusion nurses, and an inpatient team. Bone marrow transplantation needs a multidisciplinary team because of the complexity in coordinating care, says Fero. The teams Nurse Manager, Maria Limanovich, says the team follows each person from the beginning of bone marrow transplant treatment through completion.. Bone marrow, the soft reddish material that fills the inside of our bones, produces millions of new blood cells each second. These millions of cells come from a tiny number of bone marrow stem ...
We refer to two articles by Duijvestein et al and Ciccocioppo et al1 2 in which the authors suggest that administration of autologous bone marrow-derived mesenchymal stem cells (MSCs) is safe and feasible in the treatment of refractory Crohns disease (CD). However, to date there are few data about allogeneic MSC transplantation (MSCT) for patients with inflammatory bowel disease (IBD).. We wish to report our experience of allogeneic MSCT in seven patients with IBD.. Infused allogeneic MSCs were obtained from the bone marrow or umbilical cord. Bone marrow was aspirated from healthy relatives of three patients. Umbilical cords were obtained from local maternity hospitals after normal deliveries. The isolated MSCs were given by intravenous infusions … ...
ADCETRIS was granted conditional marketing authorization by the European Commission in October 2012 for two indications: (1) for the treatment of adult patients with relapsed or refractory CD30-positive Hodgkin lymphoma following autologous stem cell transplant (ASCT), or following at least two prior therapies when ASCT or multi-agent chemotherapy is not a treatment option, and (2) the treatment of adult patients with relapsed or refractory systemic anaplastic large cell lymphoma (sALCL). In January 2016, the European Commission approved a Type II variation to include data on the retreatment of adult patients with Hodgkin lymphoma or sALCL who previously responded to ADCETRIS and who later relapse. In June 2016, the European Commission extended the current conditional approval of ADCETRIS and approved ADCETRIS for the treatment of adult patients with CD30-positive Hodgkin lymphoma at increased risk of relapse or progression following ASCT. ADCETRIS has received marketing ...
Invasive mycoses represent a major cause of morbidity and mortality in patients with malignancy or undergoing hematopoietic stem cell transplantation (HSCT). Recently it has been shown that the Toll-like receptor system could play an important role in the development of invasive aspergillosis in patients receiving chemotherapy or after HSCT, and there is evidence suggesting that the involvement of Toll-like receptors during Aspergillus fumigatus infection is influenced by the immunological status of the host. The upper and lower respiratory tracts represent the most frequent locations of A. fumigatus infection in all patient categories and age groups. Among echinocandins, caspofungin has been approved for salvage therapy in patients with invasive aspergillosis, since it has been demonstrated to be well-tolerated and with a 39% response in patients with refractory infections. However, in this study as in other salvage therapy trials, the need for salvage therapy was ...
Excessive adverse events were encountered in a Phase I/II study of cyclophosphamide (CY) dose deescalation in a fludarabine-based conditioning regimen for bone marrow transplantation from unrelated donors in patients with severe aplastic anemia. All patients received fixed doses of antithymocyte globulin, fludarabine, and low-dose total body irradiation. The starting CY dose was 150 mg/kg, with deescalation to 100 mg/kg, 50 mg/kg, or 0 mg/kg. CY dose level 0 mg/kg was closed due to graft failure in 3 of 3 patients.

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Resistance to homologous transplantation of leukemic cells may be overcome by inoculation of large doses of cells into very ... Immunity towards transplanted leukemia can be passively transferred by inoculation of spleen or liver of immune animals. ... Homologous and heterologous immune sera may inactivate leukemic cells in vitro. Cytoplasmic constituents of leukemic cells are ... Heterologous transplantation of leukemic cells can be accomplished by previous radiation of the foreign host, but not by ...
more infohttp://cancerres.aacrjournals.org/content/11/10/741

Adoptive Cell Therapy-Act 1: The Beginning - The ASCO PostAdoptive Cell Therapy-Act 1: The Beginning - The ASCO Post

The authors concluded the homologous graft "might be able to produce an immune reaction to destroy any surviving leukemia cells ... Appelbaum FR: Haematopoietic cell transplantation as immunotherapy. Nature 411:385-389, 2001. ... could be cured if treated with cyclophosphamide plus infusion of viable spleen cells from mice preimmunized against FBL3.7 This ... less is known about cell-intrinsic and cell-extrinsic context-dependent resistance to graft-vs-tumor effects. Almost all ...
more infohttps://www.ascopost.com/issues/september-25-2017/adoptive-cell-therapy-act-1-the-beginning/

Expressão da enzima Indoleamina-2,3-dioxigenase em trutas Arco-Íris (Oncorhynchus...Expressão da enzima Indoleamina-2,3-dioxigenase em trutas Arco-Íris (Oncorhynchus...

The expression of IDO was observed in the inner region of small blood vessels in the head kidney, spleen, liver and peripheral ... The restricted localized expression of IDO in these tissues and cells, as occurred in mammals, may suggest a first evidence for ... In mammals, this enzyme acts on various conditions such as pregnancy, infections, chronic inflammation, transplantation and ... Recent studies have identified the presence of homologous IDO in older phylogenetically related species molecules, the ...
more infohttp://www.teses.usp.br/teses/disponiveis/10/10132/tde-09012015-093350/pt-br.php

Ronald D. Guttmann - WikipediaRonald D. Guttmann - Wikipedia

Guttmann, R.D., Aust, J.B.: Acquired tolerance to homografts produced by homologous spleen cell injection in adult mice. Nature ... Canadian Transplantation Society [4], XVII World Congress of The Transplantation Society Inc. [5], is a Fellow of the Royal ... now called American Society of Transplantation. [16](1982). Co-founder and President of the Canadian Transplantation Society [ ... Transplantation Reviews 6:189-193, 1992. cited in: Human Rights Watch Report on Judicial Execution in China.[19] Guttmann, R.D ...
more infohttps://en.wikipedia.org/wiki/Ronald_D._Guttmann

NAVER 학술정보 >...NAVER 학술정보 >...

Spleen, immunology, transplantation, Thymus Gland, Transplantation Immunology, Transplantation, Homologous ... Site of the action of toxin in living cells.. 1968 A M Jr Pappenheimer 외 1 명 Journal of Experimental Medicine 0회 피인용 ... Serological analysis of thymus and spleen grafts.. 1968 M Schlesinger 외 1 명 Journal of Experimental Medicine 0회 피인용 ... Amino Acids, analysis, Animals, Asparaginase, pharmacology, Asparagine, biosynthesis, blood, metabolism, Aspartic Acid, Cell- ...
more infohttps://academic.naver.com/search.naver?query=Journal+of+Experimental+Medicine+127%EA%B6%8C+6%ED%98%B8&searchType=1&field=3

BB rat thymocytes cultured in the presence of islets lose their abilit by Barbara J. Whalen, Jan Marounek et al."BB rat thymocytes cultured in the presence of islets lose their abilit" by Barbara J. Whalen, Jan Marounek et al.

We observed that cells recovered from adult diabetes-resistant BB (BBDR) rat thymi cultured for up to 14 days can adoptively ... Co-culture of adult BBDR thymi in the presence of BBDR thyrocytes had no effect on the ability of recovered cells to induce ... Exposure of ATOCs to exogenous islets may lead to deletion or anergy of diabetogenic T-cells or to the positive selection of ... we tested the hypothesis that cells capable of the adoptive transfer of diabetes would be present in long-term ATOCs but could ...
more infohttps://escholarship.umassmed.edu/oapubs/484/

Primed CBY lymphocytes, which reject H2-DMα−/− gra | Open-iPrimed CBY lymphocytes, which reject H2-DMα−/− gra | Open-i

... stimulator cells in a secondary MLR. Total splenocytes from H2-DMα ... To determine if donor-specific T cells had developed in recipients of H2-DMα−/− grafts, an MLR analysis of spleen cells was ... Heart Transplantation/immunology*. *Major Histocompatibility Complex*. *Th1 Cells/immunology*. *Th2 Cells/immunology* ... To determine if donor-specific T cells had developed in recipients of H2-DMα−/− grafts, an MLR analysis of spleen cells was ...
more infohttps://openi.nlm.nih.gov/detailedresult.php?img=PMC1887714_JEM992090.f3&req=4

Embryo Loss
     Summary Report | CureHunterEmbryo Loss Summary Report | CureHunter

Homologous Transplantation (Allograft) 10/01/1995 - "In early embryo loss, the fetus may be considered to be an allograft and, ... previous vaccination of CBA/J female mice with Balb/c spleen cells expressing paternal MHC antigens, complete Freunds adjuvant ... previous vaccination of CBA/J female mice with Balb/c spleen cells expressing paternal MHC antigens, complete Freunds adjuvant ... previous vaccination of CBA/J female mice with Balb/c spleen cells expressing paternal MHC antigens, complete Freunds adjuvant ...
more infohttp://www.curehunter.com/public/keywordSummaryD020964-Embryo-Resorption.do

TNO Repository search for: subject:Clone CellsTNO Repository search for: subject:'Clone Cells'

Spleen · Transplantation, Homologous ... In contrast, transplantation of cells from mice with a B cell ... Cancer graft · Clonogenesis · Tumor cell · Animal · Biological Assay · Cell Line · Cell Survival · Clone Cells · Dose-Response ... Animal · Cell Division · Cell Survival · Clone Cells · Colony-Forming Units Assay · Epitopes · H-2 Antigens · Hematopoietic ... Administration, Oral · Animal · Antineoplastic Agents · Bone Marrow · Bone Marrow Cells · Cell Differentiation · Cell Survival ...
more infohttps://repository.tudelft.nl/search/tno/?q=subject:%22Clone%20Cells%22

Albert Edge | Harvard Catalyst Profiles | Harvard CatalystAlbert Edge | Harvard Catalyst Profiles | Harvard Catalyst

... current progress and future developments in porcine cell transplantation. Cell Transplant. 1998 Nov-Dec; 7(6):525-39. PMID: ... Transplantation. Route of hepatocyte delivery affects hepatocyte engraftment in the spleen. 2003; 76:732-734. ... identification of a porcine antigen homologous to CD58. Transplantation. 2004 Apr 27; 77(8):1288-94. PMID: 15114100. ... Human natural killer cells account for non-MHC class I-restricted cytolysis of porcine cells. Cell Immunol. 1997 Feb 01; 175(2 ...
more infohttps://connects.catalyst.harvard.edu/profiles/display/Person/60563

Keratinocyte growth factor and androgen blockade work in concert to protect against conditioning regimen-induced thymic...Keratinocyte growth factor and androgen blockade work in concert to protect against conditioning regimen-induced thymic...

Combined therapy facilitated T:B cooperativity and enabled a B-cell humoral response to a CD4 T cell-dependent neoantigen ... In vivo antigen-specific CD8 T-cell responses and clearance of a live pathogen was superior with combined versus individual ... peripheral reconstitution of naive CD4 and CD8 T cells with a broad Vbeta repertoire and decreased homeostatic T-cell ... slow T-cell reconstitution, and a high risk of opportunistic infections. Keratinocyte growth factor (KGF) stimulates TEC ...
more infohttps://www.paediatrics.ox.ac.uk/publications/309032

Multiple effector roles of lymphocytes in allograft immunity. by C K. Grant, R Evans et al.Multiple effector roles of lymphocytes in allograft immunity." by C K. Grant, R Evans et al.

Spleen: im, T-Lymphocytes: im, Thymectomy, Thymus-Gland: ph, Transplantation-Immunology, Transplantation-Homologous ... Antibody-Formation, Antigen-Antibody-Reactions, Cells-Cultured, Chromium-Isotopes, Complement-Fixation-Tests, Cytotoxicity- ...
more infohttps://mouseion.jax.org/stfb1970_1979/345/

Hereditary disorders of the red cell in animals. by R M Bannerman, J A Edwards et al."Hereditary disorders of the red cell in animals." by R M Bannerman, J A Edwards et al.

Spleen, Transplantation, Homologous ... Anemia, Animals, Bone Marrow Cells, Bone Marrow Transplantation ... Bannerman, R M; Edwards, J A; and Pinkerton, P H, "Hereditary disorders of the red cell in animals." (1973). Subject Strain ... Hematopoietic Stem Cells, Hemoglobins, Mice, Mutation, Parabiosis, Pigmentation Disorders, Rats, Rodent Diseases, Sex ... Cell Division, Disease Models, Animal, Dog Diseases, Dogs, Erythrocytes, Abnormal, Erythropoiesis, Erythropoietin, ...
more infohttps://mouseion.jax.org/ssbb1973/1481/

TNO Repository search for: creator:Zurcher, C.TNO Repository search for: creator:'Zurcher, C.'

Spleen · Transplantation, Homologous ... In contrast, transplantation of cells from mice with a B cell ... Typical sarcoma virus lesions developed in newborn rats injected with virus-producing rabbit cells. Cells producing only the ... Studies with bromodeoxyuridine confirm the increased rate of epithelial cell proliferation. Most inflammatory cells in the ... lethally irradiated mice and also equally as well in nonirradiated recipients by a bone marrow and/or spleen cell transfer. The ...
more infohttps://repository.tudelft.nl/search/tno/?q=creator%3A%22Zurcher%2C%20C.%22

Frontiers | Milestones of Hematopoietic Stem Cell Transplantation - From First Human Studies to Current Developments |...Frontiers | Milestones of Hematopoietic Stem Cell Transplantation - From First Human Studies to Current Developments |...

Besides bone marrow (BM) other stem cell sources like G-CSF-mobilized peripheral blood stem cells and cord blood stem cells ... Besides bone marrow (BM) other stem cell sources like G-CSF-mobilized peripheral blood stem cells and cord blood stem cells ... The latter has been accomplished by potent graft-versus-leukemia effector cells contained in the stem cell graft. Exciting ... The latter has been accomplished by potent graft-versus-leukemia effector cells contained in the stem cell graft. Exciting ...
more infohttps://www.frontiersin.org/articles/10.3389/fimmu.2016.00470/full

Transplantation of hematopoietic stem cells: historical aspectsTransplantation of hematopoietic stem cells: historical aspects

Effect of spleen protection on mortality following x-irradiation. J Lab Clin Med. 1949; 34:1538-1543.. ... Treatment of murine leukaemia with x-rays and homologous bone marrow. Preliminary communication. Br Med J. 1956; 2:626-627.. ... Transplantation of hematopoietic stem cells: historical aspects. Khomenko V. I.. Kyiv Center of Bone Marrow Transplantation, ... Transplantation of hematopoietic stem cells: historical aspects. Home/2018, Vol. 6, No. 2/Transplantation of hematopoietic stem ...
more infohttp://transplantology.org/2018-6-2-en/article-1/

Induction of Contrasuppressor Cells and Loss of Immune Privilege Produced by Corneal Nerve Ablation | IOVS | ARVO JournalsInduction of Contrasuppressor Cells and Loss of Immune Privilege Produced by Corneal Nerve Ablation | IOVS | ARVO Journals

... cells into CS cells. (A) Adoptive transfer of in vitro generated CS cells was tested by incubating naïve CD11c+ BALB/c spleen ... CD4(+) T-cell-mediated mechanisms of corneal allograft rejection: role of Fas-induced apoptosis. Transplantation. 2005; 79: 23- ... Immunity to homologous grafted skin. III. The fate of skin homografts transplanted to the brain, to subcutaneous tissue, and to ... cells into CS cells. (A) Adoptive transfer of in vitro generated CS cells was tested by incubating naïve CD11c+ BALB/c spleen ...
more infohttp://iovs.arvojournals.org/article.aspx?articleid=2705450

DiVA - Search resultDiVA - Search result

Islet transplantation is a promising treatment for type 1 diabetes mellitus, but the fate of the cells after intraportal ... MK-7246 is a potent and selective antagonist for chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2). ... However, the uptake of DOTA-ZHER2:342min in lung, liver and spleen was appreciably higher than the uptake of PEP09239-based ... METHODS: MTS of two breast cancer cell lines (MCF-7 and BT474), one glioblastoma cell line (U87MG) and one colon carcinoma cell ...
more infohttp://uu.diva-portal.org/smash/resultList.jsf?af=%5B%5D&aq=%5B%5B%7B%22journalId%22%3A%229703%22%7D%5D%5D&aqe=%5B%5D&aq2=%5B%5B%5D%5D&language=en&query=

Bone Marrow Graft Rejection as a Function of TNK Cells | SpringerLinkBone Marrow Graft Rejection as a Function of TNK Cells | SpringerLink

Cudkowicz G, Cosgrove GE (1961): Modified homologous disease following transplantation of parental bone marrow and recipient ... Specific inhibition of hybrid resistance in F1 hybrid mice pretreated with parent-strain spleen cells. J Immunol 143: 3484-3491 ... Pollack SB, Kraft DS (1977): Effector cells which mediate antibody-dependent cell-mediated cytotoxicity Cell Immunol 34: 1-9 ... In: NK Cells and Other Natural Effector Cells, Herberman RB, ed. New York: Academic PressGoogle Scholar ...
more infohttps://link.springer.com/chapter/10.1007/978-1-4684-6814-4_39

topic:Livers found 92 records • Arctic Healthtopic:"Livers" found 92 records • Arctic Health

Spleen - cytology - immunology Survival Rate Transplantation, Homologous Xenograft Model Antitumor Assays Abstract. We have ... whole cells), CD4(+) cell-depleted spleen cells (CD4(-) cells) or CD8(+) cell-depleted spleen cells (CD8(-) cells) of BN rats. ... cell-depleted spleen cells (CD4(-) cells) can prevent graft-versus-host disease (GvHD) but suppress tumor growth (Meth A: ... Bone Marrow Transplantation CD4-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - immunology Cell Proliferation ...
more infohttps://arctichealth.org/en/list?q=topic%3A%22Livers%22&p=1&ps=&sort=title_sort+asc&topic_facet=Survival+Rate

Release of cytokines by spleen cells restimulated or no | Open-iRelease of cytokines by spleen cells restimulated or no | Open-i

Spleen cells from untreated control mice (white bar); from mice treated w ... Release of cytokines by spleen cells restimulated or not in vitro with Neu/H-2q cells. ... fig6: Release of cytokines by spleen cells restimulated or not in vitro with Neu/H-2q cells. Spleen cells from untreated ... fig6: Release of cytokines by spleen cells restimulated or not in vitro with Neu/H-2q cells. Spleen cells from untreated ...
more infohttps://openi.nlm.nih.gov/detailedresult.php?img=PMC2195980_001757f6&req=4

Yukiko Ohyama - Research Output
     - Kyushu UniversityYukiko Ohyama - Research Output - Kyushu University

T-cell receptor Vβ gene usage by T cells reactive with the tumor-rejection antigen SART-1 in oral squamous cell carcinoma. ... Oral involvement in chronic graft-versus-host disease after allogeneic bone marrow transplantation. Nakamura, S., Hiroki, A., ... T-cell receptor Vα and Vβ gene use by infiltrating T cells in labial glands of patients with Sjögrens syndrome. Ohyama, Y., ... T cell receptor Vα and Vβ gene usage by tumour-infiltrating lymphocytes in oral squamous cell carcinoma. Mouri, T., Nakamura, S ...
more infohttps://kyushu-u.pure.elsevier.com/en/persons/yukiko-ohyama/publications/?type=%2Fdk%2Fatira%2Fpure%2Fresearchoutput%2Fresearchoutputtypes%2Fcontributiontojournal%2Farticle

Brutons tyrosine kinase (BTK) function is important to the development and expansion of chronic lymphocytic leukemia (CLL) |...Bruton's tyrosine kinase (BTK) function is important to the development and expansion of chronic lymphocytic leukemia (CLL) |...

... leukemic spleen lymphocytes were obtained from B6/TCL1 mice with high white blood cell counts and splenomegaly. Spleens were ... Chronic lymphocytic leukemia (CLL) is a common adult leukemia that is currently incurable outside of stem cell transplantation ... binds BTK at cysteine 481 within the hinge region and potentially cross-reacts with similar kinases that possess a homologous ... average 1843 B cells/μL and 1379 T cells/μL in XID/TCL1 vs 2157 B cells/μL and 1236 T cells/μL in WT/TCL1 mice). We next ...
more infohttp://www.bloodjournal.org/content/123/8/1207?sso-checked=true

NF-κB RelA-deficient Lymphocytes: Normal Development of  T Cells and B Cells, Impaired Production of IgA and IgG1 and Reduced...NF-κB RelA-deficient Lymphocytes: Normal Development of T Cells and B Cells, Impaired Production of IgA and IgG1 and Reduced...

Surface antigen profiles of spleen cells and thymocytes of SCID mice transplanted with ED13.5 fetal liver cells. Cells were ... Transplantation of relA−/− Fetal Liver Cells.. During normal embryonic development, hematopoietic stem cells emerge in the ... To investigate the function of NF-κB RelA (p65), we generated mice deficient in this NF-κB family member by homologous ... spleen cells showed a much lower [3H]thymidine uptake than relA+/+ or +/− spleen cells (Table 2). To test whether this low ...
more infohttp://jem.rupress.org/content/185/5/953?ijkey=665cfe93919778bd3717d72a4fa85fe089175804&keytype2=tf_ipsecsha

Development of Congenital Stromal Corneal Dystrophy Is Dependent on Export and Extracellular Deposition of Truncated Decorin |...Development of Congenital Stromal Corneal Dystrophy Is Dependent on Export and Extracellular Deposition of Truncated Decorin |...

Mice were constructed by homologous recombination of the modified decorin gene into ES cells, which then were introduced into ... Lung, heart, liver, kidney, spleen, skin, and gastrocnemius tendon were sampled for histopathology. The samples were fixed in 4 ... Human CSCD corneas were obtained after consent from patients undergoing corneal transplantation. Healthy corneas were obtained ... Human corneal cells secreted wt and truncated decorin, whereas murine cells only secreted wt decorin. As shown in Figure 5E, no ...
more infohttps://iovs.arvojournals.org/article.aspx?articleid=2294043
  • Based on these observations, we tested the hypothesis that cells capable of the adoptive transfer of diabetes would be present in long-term ATOCs but could be rendered nondiabetogenic by co-culture with appropriate antigens. (umassmed.edu)
  • Antisera directed against histocompatibility-2 antigens of the mouse suppress the formation of spleen colonies by pluripotent hemopoietic stem cells. (tudelft.nl)
  • If the titer of the CFU-s suppressive effect of the antisera is compared to their toxicity to spleen lymphocytes, it can be concluded that CFU-s express antigens in the same density as spleen lymphocytes. (tudelft.nl)
  • 13. Van Rood J. J. The detection of transplantation antigens in leukocytes. (transplantology.org)
  • Corneal nerve injury that occurs during keratoplasty converts ocular surface CD11c + cells into CS cells that block CD8 + Tregs, which are induced by introducing antigens into the anterior chamber (i.e. (arvojournals.org)
  • 2 For more than a half century, immune privilege was viewed as an anatomical anomaly in which the interior of the eye lacked lymph vessels to shuttle antigens and antigen presenting cells to regional lymph nodes. (arvojournals.org)
  • The observation was unexpected, as transplantation antigens are known to be inherited codominantly (Snell, 1953) and therefore parental marrow grafts should not be subject to immunological rejection mechanisms. (springer.com)
  • Serological analysis of thymus and spleen grafts. (naver.com)
  • Residual cytolytic T cell and antibody responses against intact MHC class I lead to eventual rejection.Removal of both H2-DMalpha and beta2-microglobulin (beta2m) in cardiac grafts lead to greater (8-10 times) graft survival, whereas removal of beta2m alone did not have any effect.These results demonstrate the significance of peptide rather than just allogeneic MHC, in eliciting graft rejection. (nih.gov)
  • Proliferative T cell response was absent, and cytolytic response was reduced against the H2-DMalpha(-/)- grafts in vivo. (nih.gov)
  • Primed CBY lymphocytes, which reject H2-DMα−/− grafts, do not respond to H2-DMα−/− stimulator cells in a secondary MLR. (nih.gov)
  • One possible explanation for the delayed rejection of H2-DMα−/− grafts is that the precursor frequency of CLIP-I-Ab-specific T cells is low in the recipients, and it simply takes longer for these cells to expand and efficiently mediate graft rejection. (nih.gov)
  • To determine if donor-specific T cells had developed in recipients of H2-DMα−/− grafts, an MLR analysis of spleen cells was performed from animals that had received cardiac allografts. (nih.gov)
  • In vivo blockade of costimulatory signal at day 4 of gestation can induce the immuno-tolerance of maternal peripheral immuno-competent cells to paternal antigen, thus leading the embryo resorption rate of the abortion-prone model to that of normal pregnancy model. (curehunter.com)
  • Methods: Peripheral blood mononudear cells from patients with peanut allergy and nonallergic individuals were stimulated with crude peanut extract (CPE) to compare the proliferative responses and to select a suitable patient for the cloning of CPE-specific T cells. (tudelft.nl)
  • 0.05) than in peripheral blood mononudear cells of nonallergic donors. (tudelft.nl)
  • Conclusions: This study demonstrates that peanut-specific T cells do occur in the peripheral blood of patients with peanut allergy and suggests an increased frequency of these T cells in patients compared with nonallergic control subjects. (tudelft.nl)
  • Thymopoiesis and thymic output were supranormal, leading to the accelerated peripheral reconstitution of naive CD4 and CD8 T cells with a broad Vbeta repertoire and decreased homeostatic T-cell proliferation. (ox.ac.uk)
  • Thus, KGF combined with androgen blockade represents a novel approach to restore thymic function and facilitates the rapid recovery of peripheral T-cell function after allogeneic BMT. (ox.ac.uk)
  • In contrast, animals given homologous (allogeneic) marrow lived, on average, twice as long posttransplant before dying free of leukemia but with a "wasting syndrome," which we now know to be graft-vs-host disease. (ascopost.com)
  • 5 But until the work of Barnes and Loutit, it had never been demonstrated that tumors could be eradicated by the transfer of cells. (ascopost.com)
  • These results suggest that allogeneic IBM-BMT + DLI using CD4(-) cells could become a new strategy for the treatment of solid tumors. (arctichealth.org)
  • IL-12 treatment strongly increased the cell vaccine efficacy.Specific anti-HER-2/neu antibodies were produced and a nonpolarized activation of CD4(+) and CD8(+) cells secreting IL-4 and interferon (IFN)-gamma were evident.In conclusion, our data show that an allogeneic HER-2/neu-expressing cell vaccine combined with IL-12 systemic treatment can prevent the onset of genetically determined tumors. (nih.gov)
  • In conclusion, our data show that an allogeneic HER-2/neu-expressing cell vaccine combined with IL-12 systemic treatment can prevent the onset of genetically determined tumors. (nih.gov)
  • They found that many types of transplantable tumors caused a five to tenfold increase in the plasma lactate dehydrogenase (LDH) activity within three days of the transplantation. (wikipedia.org)
  • In 1969, he was appointed Associate in Medicine at the Peter Bent Brigham Hospital and Instructor in Medicine at Harvard Medical School, and permanently moved to Montreal, Canada in 1970 to become Director of the Transplantation Service at the Royal Victoria Hospital and McGill University Clinic and Associate Professor of Medicine, McGill University Faculty of Medicine. (wikipedia.org)
  • When we do not contain diaphragms fig endothelial cells in rat kidney am j physiol pharmacol a drugs used skin turgor poor capillary return handbook of pediatric emergency medicine suggested reading liebelt e l clinical and laboratory evaluation and treatment of aspiration of gastric or duodenal ulceration is no proven benefit formula changes are called essential amino acids and iron. (nationalnewstoday.com)
  • The fibronectin splice variant ED-B, a small domain of 91 amino acids, which is homologous from mouse to man, is usually absent in both plasma and tissue-fibronectin, except for some blood vessels of the regenerating endometrium and the ovaries ( 6 , 8 ). (aacrjournals.org)
  • It is also known that the development of BB rat T-cells is recapitulated in adult thymus organ cultures (ATOCs). (umassmed.edu)
  • Suppresses hypersensitivities of cell-mediated type and variably alters antibody production. (medscape.com)
  • Temporary growth of leukemic cells in foreign strains may be accelerated or inhibited by multiple prior injections of frozen, lyophilized tissue. (aacrjournals.org)
  • 7 This was the first report of a therapy conceptually analogous to the chimeric antigen receptor (CAR) T-cell therapies that are the current stars in our play. (ascopost.com)
  • In vivo antigen-specific CD8 T-cell responses and clearance of a live pathogen was superior with combined versus individual agent therapy. (ox.ac.uk)
  • For the maximum prevention p185(neu) antigen must be expressed by allogeneic cells. (nih.gov)
  • It was further increased in an antigen-specific manner by the addition of mitomycin-blocked syngeneic Neu/H-2d cells. (nih.gov)
  • Chronic lymphocytic leukemia (CLL) is characterized by constitutive activation of the B-cell receptor (BCR) signaling pathway, but variable responsiveness of the BCR to antigen ligation. (bloodjournal.org)
  • Background: Increasing evidence indicates a prominent role of allergen-specific TH2 cells, with high IL-4 and IL-5 production and low interferon-γ production, in the regulation of IgE and eosinophil production in allergic disorders. (tudelft.nl)
  • Hereditary disorders of the red cell in animals. (jax.org)
  • and Pinkerton, P H, "Hereditary disorders of the red cell in animals. (jax.org)
  • Exposure of ATOCs to exogenous islets may lead to deletion or anergy of diabetogenic T-cells or to the positive selection of regulatory T-cells. (umassmed.edu)
  • Cytoplasmic constituents of leukemic cells are more highly antigenic than nuclei. (aacrjournals.org)
  • He subsequently postulated that the antigenic determinants recognized during the rejection are expressed on parental and not on F1 hybrid cells and hence must be inherited noncodominantly (Cudkowicz and Stimpfling, 1964). (springer.com)
  • However, most studies have concentrated on T cells reactive with inhalation allergens, whereas little is known about the properties of food allergen-reactive T cells. (tudelft.nl)
  • The developing blood cells also have problems expressing several genes, including one that helps to protect the cells from damaging molecules called reactive oxygen species. (elifesciences.org)
  • Freezing and lyophilization of mouse leukemic cells render them inactive for transmitting leukemia. (aacrjournals.org)
  • ON AUGUST 30, 2017 , the first genetically engineered T-cell therapy (tisagenlecleucel [Kymriah]) was approved by the U.S. Food and Drug Administration (FDA) for the treatment of patients up to 25 years of age with B-cell precursor acute lymphoblastic leukemia that is refractory or in second or later relapse. (ascopost.com)
  • The latter has been accomplished by potent graft-versus-leukemia (GvL) effector cells contained in the stem cell graft. (frontiersin.org)
  • The shelf-life was also evaluated in vitro , showing no reduction in labeling yield or binding capacity to HER2-expressing cells after over 400 days of storage of the single-vial freeze-dried kit. (diva-portal.org)
  • Release of cytokines by spleen cells restimulated or not in vitro with Neu/H-2q cells. (nih.gov)
  • CD11c + CS cells were evaluated by adoptive transfer and by their capacity to disable CD8 + ACAID Tregs in local adoptive transfer (LAT) of suppression assays. (arvojournals.org)
  • The CPE-specific T-lymphocyte clones generated from the selected patient were all CD4+/CD8- T helper cells with a TH2 cytokine profile, secreting high amounts of IL-4 and IL-5, but little or no interferon-γ. (tudelft.nl)
  • The CD4+ phenotype and the TH2 cytokine profile of the CPE-specific T-lymphocyte clones suggest a functional role of allergen-specific TH2 cells in the pathophysiology of food allergy, similar to the function of inhalation allergen-specific TH2 cells. (tudelft.nl)
  • Depletion of resident CD11c + cells at the ocular surface prevented the generation of CS cells. (arvojournals.org)
  • Depletion of CD11c + cells at the ocular surface prevents the generation of CS cells and may be a useful strategy for preventing SLIP and enhancing the survival of second corneal transplants. (arvojournals.org)
  • The functional relevance of NK cells for the therapeutic effect of the targeted immunocytokine L19-IL-2 was confirmed by NK cell depletion, which completely abolished its antitumor efficacy. (aacrjournals.org)