HLA Antigens: Antigens determined by leukocyte loci found on chromosome 6, the major histocompatibility loci in humans. They are polypeptides or glycoproteins found on most nucleated cells and platelets, determine tissue types for transplantation, and are associated with certain diseases.HLA-DQ Antigens: A group of the D-related HLA antigens found to differ from the DR antigens in genetic locus and therefore inheritance. These antigens are polymorphic glycoproteins comprising alpha and beta chains and are found on lymphoid and other cells, often associated with certain diseases.HLA-DRB1 Chains: A subtype of HLA-DRB beta chains that includes over one hundred allele variants. The HLA-DRB1 subtype is associated with several of the HLA-DR SEROLOGICAL SUBTYPES.HLA-DQ alpha-Chains: Transmembrane proteins that form the alpha subunits of the HLA-DQ antigens.HLA-DQ beta-Chains: Transmembrane proteins that form the beta subunits of the HLA-DQ antigens.HLA-A3 Antigen: A specific HLA-A surface antigen subtype. Members of this subtype contain alpha chains that are encoded by the HLA-A*03 allele family.HLA-DRB4 Chains: A subtype of HLA-DRB beta chains that is associated with the HLA-DR53 serological subtype.HLA-DR Antigens: A subclass of HLA-D antigens that consist of alpha and beta chains. The inheritance of HLA-DR antigens differs from that of the HLA-DQ ANTIGENS and HLA-DP ANTIGENS.HLA-B7 Antigen: A specific HLA-B surface antigen subtype. Members of this subtype contain alpha chains that are encoded by the HLA-B*07 allele family.Histocompatibility Testing: Identification of the major histocompatibility antigens of transplant DONORS and potential recipients, usually by serological tests. Donor and recipient pairs should be of identical ABO blood group, and in addition should be matched as closely as possible for HISTOCOMPATIBILITY ANTIGENS in order to minimize the likelihood of allograft rejection. (King, Dictionary of Genetics, 4th ed)HLA-B Antigens: Class I human histocompatibility (HLA) surface antigens encoded by more than 30 detectable alleles on locus B of the HLA complex, the most polymorphic of all the HLA specificities. Several of these antigens (e.g., HLA-B27, -B7, -B8) are strongly associated with predisposition to rheumatoid and other autoimmune disorders. Like other class I HLA determinants, they are involved in the cellular immune reactivity of cytolytic T lymphocytes.Genes, MHC Class I: Genetic loci in the vertebrate major histocompatibility complex which encode polymorphic characteristics not related to immune responsiveness or complement activity, e.g., B loci (chicken), DLA (dog), GPLA (guinea pig), H-2 (mouse), RT-1 (rat), HLA-A, -B, and -C class I genes of man.Alleles: Variant forms of the same gene, occupying the same locus on homologous CHROMOSOMES, and governing the variants in production of the same gene product.HLA-A Antigens: Polymorphic class I human histocompatibility (HLA) surface antigens present on almost all nucleated cells. At least 20 antigens have been identified which are encoded by the A locus of multiple alleles on chromosome 6. They serve as targets for T-cell cytolytic responses and are involved with acceptance or rejection of tissue/organ grafts.HLA-C Antigens: Class I human histocompatibility (HLA) antigens encoded by a small cluster of structural genes at the C locus on chromosome 6. They have significantly lower immunogenicity than the HLA-A and -B determinants and are therefore of minor importance in donor/recipient crossmatching. Their primary role is their high-risk association with certain disease manifestations (e.g., spondylarthritis, psoriasis, multiple myeloma).Major Histocompatibility Complex: The genetic region which contains the loci of genes which determine the structure of the serologically defined (SD) and lymphocyte-defined (LD) TRANSPLANTATION ANTIGENS, genes which control the structure of the IMMUNE RESPONSE-ASSOCIATED ANTIGENS, HUMAN; the IMMUNE RESPONSE GENES which control the ability of an animal to respond immunologically to antigenic stimuli, and genes which determine the structure and/or level of the first four components of complement.Genes, MHC Class II: Genetic loci in the vertebrate major histocompatibility complex that encode polymorphic products which control the immune response to specific antigens. The genes are found in the HLA-D region in humans and in the I region in mice.Haplotypes: The genetic constitution of individuals with respect to one member of a pair of allelic genes, or sets of genes that are closely linked and tend to be inherited together such as those of the MAJOR HISTOCOMPATIBILITY COMPLEX.Histocompatibility Antigens Class I: Membrane glycoproteins consisting of an alpha subunit and a BETA 2-MICROGLOBULIN beta subunit. In humans, highly polymorphic genes on CHROMOSOME 6 encode the alpha subunits of class I antigens and play an important role in determining the serological specificity of the surface antigen. Class I antigens are found on most nucleated cells and are generally detected by their reactivity with alloantisera. These antigens are recognized during GRAFT REJECTION and restrict cell-mediated lysis of virus-infected cells.Genetic Predisposition to Disease: A latent susceptibility to disease at the genetic level, which may be activated under certain conditions.Gene Frequency: The proportion of one particular in the total of all ALLELES for one genetic locus in a breeding POPULATION.Genotype: The genetic constitution of the individual, comprising the ALLELES present at each GENETIC LOCUS.Polymorphism, Genetic: The regular and simultaneous occurrence in a single interbreeding population of two or more discontinuous genotypes. The concept includes differences in genotypes ranging in size from a single nucleotide site (POLYMORPHISM, SINGLE NUCLEOTIDE) to large nucleotide sequences visible at a chromosomal level.Linkage Disequilibrium: Nonrandom association of linked genes. This is the tendency of the alleles of two separate but already linked loci to be found together more frequently than would be expected by chance alone.Diabetes Mellitus, Type 1: A subtype of DIABETES MELLITUS that is characterized by INSULIN deficiency. It is manifested by the sudden onset of severe HYPERGLYCEMIA, rapid progression to DIABETIC KETOACIDOSIS, and DEATH unless treated with insulin. The disease may occur at any age, but is most common in childhood or adolescence.High-Throughput Nucleotide Sequencing: Techniques of nucleotide sequence analysis that increase the range, complexity, sensitivity, and accuracy of results by greatly increasing the scale of operations and thus the number of nucleotides, and the number of copies of each nucleotide sequenced. The sequencing may be done by analysis of the synthesis or ligation products, hybridization to preexisting sequences, etc.Polymorphism, Single Nucleotide: A single nucleotide variation in a genetic sequence that occurs at appreciable frequency in the population.Base Sequence: The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.DNA Probes, HLA: DNA probes specific for the human leukocyte antigen genes, which represent the major histocompatibility determinants in humans. The four known loci are designated as A, B, C, and D. Specific antigens are identified by a locus notation and number, e.g., HLA-A11. The inheritance of certain HLA alleles is associated with increased risk for certain diseases (e.g., insulin-dependent diabetes mellitus).HLA-D Antigens: Human immune-response or Class II antigens found mainly, but not exclusively, on B-lymphocytes and produced from genes of the HLA-D locus. They are extremely polymorphic families of glycopeptides, each consisting of two chains, alpha and beta. This group of antigens includes the -DR, -DQ and -DP designations, of which HLA-DR is most studied; some of these glycoproteins are associated with certain diseases, possibly of immune etiology.HLA-DR Serological Subtypes: HLA-DR antigen subtypes that have been classified according to their affinity to specific ANTIBODIES. The DNA sequence analyses of HLA-DR ALPHA-CHAINS and HLA-DR BETA-CHAINS has for the most part revealed the specific alleles that are responsible for each serological subtype.HLA-DR3 Antigen: An HLA-DR antigen which is associated with HLA-DRB1 CHAINS encoded by DRB1*03 alleles.Histocompatibility Antigens Class II: Large, transmembrane, non-covalently linked glycoproteins (alpha and beta). Both chains can be polymorphic although there is more structural variation in the beta chains. The class II antigens in humans are called HLA-D ANTIGENS and are coded by a gene on chromosome 6. In mice, two genes named IA and IE on chromosome 17 code for the H-2 antigens. The antigens are found on B-lymphocytes, macrophages, epidermal cells, and sperm and are thought to mediate the competence of and cellular cooperation in the immune response. The term IA antigens used to refer only to the proteins encoded by the IA genes in the mouse, but is now used as a generic term for any class II histocompatibility antigen.HLA-DP Antigens: A group of the D-related HLA antigens (human) found to differ from the DR antigens in genetic locus and therefore inheritance. These antigens are polymorphic glycoproteins comprising alpha and beta chains and are found on lymphoid and other cells, often associated with certain diseases.HLA-DR4 Antigen: An HLA-DR antigen which is associated with HLA-DRB1 CHAINS encoded by DRB1*04 alleles.HLA-B44 Antigen: A specific HLA-B surface antigen subtype. Members of this subtype contain alpha chains that are encoded by the HLA-B*44 allele family.HLA-B27 Antigen: A specific HLA-B surface antigen subtype. Members of this subtype contain alpha chains that are encoded by the HLA-B*27 allele family.HLA-A2 Antigen: A specific HLA-A surface antigen subtype. Members of this subtype contain alpha chains that are encoded by the HLA-A*02 allele family.HLA-B8 Antigen: A specific HLA-B surface antigen subtype. Members of this subtype contain alpha chains that are encoded by the HLA-B*08 allele family.HLA-DP beta-Chains: Transmembrane proteins that form the beta subunits of the HLA-DP antigens.Histocompatibility: The degree of antigenic similarity between the tissues of different individuals, which determines the acceptance or rejection of allografts.HLA-A1 Antigen: A specific HLA-A surface antigen subtype. Members of this subtype contain alpha chains that are encoded by the HLA-A*01 allele family.Epitopes, T-Lymphocyte: Antigenic determinants recognized and bound by the T-cell receptor. Epitopes recognized by the T-cell receptor are often located in the inner, unexposed side of the antigen, and become accessible to the T-cell receptors after proteolytic processing of the antigen.HLA-B35 Antigen: A specific HLA-B surface antigen subtype. Members of this subtype contain alpha chains that are encoded by the HLA-B*35 allele family.T-Lymphocytes, Cytotoxic: Immunized T-lymphocytes which can directly destroy appropriate target cells. These cytotoxic lymphocytes may be generated in vitro in mixed lymphocyte cultures (MLC), in vivo during a graft-versus-host (GVH) reaction, or after immunization with an allograft, tumor cell or virally transformed or chemically modified target cell. The lytic phenomenon is sometimes referred to as cell-mediated lympholysis (CML). These CD8-positive cells are distinct from NATURAL KILLER CELLS and NATURAL KILLER T-CELLS. There are two effector phenotypes: TC1 and TC2.Isoantibodies: Antibodies from an individual that react with ISOANTIGENS of another individual of the same species.Epitopes: Sites on an antigen that interact with specific antibodies.Receptors, KIR: A family of receptors found on NK CELLS that have specificity for a variety of HLA ANTIGENS. KIR receptors contain up to three different extracellular immunoglobulin-like domains referred to as D0, D1, and D2 and play an important role in blocking NK cell activation against cells expressing the appropriate HLA antigens thus preventing cell lysis. Although they are often referred to as being inhibitory receptors, a subset of KIR receptors may also play an activating role in NK cells.HLA-DR5 Antigen: A broad-specificity HLA-DR antigen that is associated with HLA-DRB1 CHAINS encoded by DRB1*11 and DRB1*12 alleles.beta 2-Microglobulin: An 11-kDa protein associated with the outer membrane of many cells including lymphocytes. It is the small subunit of the MHC class I molecule. Association with beta 2-microglobulin is generally required for the transport of class I heavy chains from the endoplasmic reticulum to the cell surface. Beta 2-microglobulin is present in small amounts in serum, csf, and urine of normal people, and to a much greater degree in the urine and plasma of patients with tubular proteinemia, renal failure, or kidney transplants.HLA-DR2 Antigen: A broad specificity HLA-DR antigen that is associated with HLA-DRB1 CHAINS encoded by DRB1*01:15 and DRB1*01:16 alleles.Antigen Presentation: The process by which antigen is presented to lymphocytes in a form they can recognize. This is performed by antigen presenting cells (APCs). Some antigens require processing before they can be recognized. Antigen processing consists of ingestion and partial digestion of the antigen by the APC, followed by presentation of fragments on the cell surface. (From Rosen et al., Dictionary of Immunology, 1989)Tissue Donors: Individuals supplying living tissue, organs, cells, blood or blood components for transfer or transplantation to histocompatible recipients.HLA-G Antigens: Class I human histocompatibility (HLA) surface antigens encoded by alleles on locus B of the HLA complex. The HLA-G antigens are considered non-classical class I antigens due to their distinct tissue distribution which differs from HLA-A; HLA-B; and HLA-C antigens. Note that several isoforms of HLA-G antigens result from alternative splicing of messenger RNAs produced from the HLA-G*01 allele.HLA-DRB5 Chains: A subtype of HLA-DRB beta chains that is associated with the HLA-DR51 serological subtype.Cytotoxicity, Immunologic: The phenomenon of target cell destruction by immunologically active effector cells. It may be brought about directly by sensitized T-lymphocytes or by lymphoid or myeloid "killer" cells, or it may be mediated by cytotoxic antibody, cytotoxic factor released by lymphoid cells, or complement.HLA-DRB3 Chains: A subtype of HLA-DRB beta chains that includes over 50 allelic variants. The HLA-DRB3 beta-chain subtype is associated with HLA-DR52 serological subtype.HLA-DR7 Antigen: A HLA-DR antigen that is associated with HLA-DRB1 CHAINS encoded by DRB1*07 alleles.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
HLA-B61, an HLA serotype. *Sicilian, Richter-Rauzer, Encyclopaedia of Chess Openings code ... an alternative name for the ephrin A1 human gene. B-61 may refer to:. *B-61 Matador, the first operational surface-to-surface ...
"HLA in the Azores Archipelago: possible presence of Mongoloid genes". Tissue Antigens. Department of Internal Medicine, ... "HLA in the Azores Archipelago: possible presence of Mongoloid genes". Tissue Antigens. Department of Internal Medicine, ... "HLA in the Azores Archipelago: possible presence of Mongoloid genes". Tissue Antigens. Department of Internal Medicine, ... have brought the N3 Y chromosome to the Azores and the people of the Azores island of Terceira have a large amount of HLA genes ...
The condition has been linked to variation in the HLA genes. Furthermore, there is genetic evidence of a high prevalence of the ... As a recessive gene, Sickle-cell disease is only present if homozygous, with no dominant gene to beat them out. Sickle-cell ... its genes are passed on to the next generation. Some of these genes may increase an organism's fitness while some may even be ... Genes that may have been advantageous in the past may be critically unfit for individuals in today's environment. Natural ...
Gene, geographie und Sprache. In: Gene, Sprachen und ihre Evolution. G. Hauska (ed.), Universitätsverlag Regensburg GmbH, ... HLA-DQ haplotypes in 15 different populations. In: The Major Histocompatibility Complex: Evolution, Structure and Function. M ... In: Genes, Fossils and Behaviour. P. Donnelly and R. Foley (eds.), IOS Press, Amsterdam, The Netherlands, pp. 111-121. Nasidze ... His team had found that human androgen receptor gene is the major factor associated with baldness in men. They also identified ...
"Entrez Gene: S1PR3 sphingosine-1-phosphate receptor 3". Hla T, Lee MJ, Ancellin N, et al. (2000). "Sphingosine-1-phosphate ... This gene encodes a member of the EDG family of receptors, which are G protein-coupled receptors. This protein has been ... Sphingosine-1-phosphate receptor 3 also known as S1PR3 is a human gene which encodes a G protein-coupled receptor which binds ... Windh RT, Lee MJ, Hla T, et al. (1999). "Differential coupling of the sphingosine 1-phosphate receptors Edg-1, Edg-3, and H218/ ...
"Entrez Gene: BAT1 HLA-B associated transcript 1". Human DDX39B genome location and DDX39B gene details page in the UCSC Genome ... A cluster of genes, BAT1-BAT5, is localized in the vicinity of the genes for TNF alpha and TNF beta. These genes are all within ... Spliceosome RNA helicase BAT1 is an enzyme that in humans is encoded by the BAT1 gene. This gene encodes a member of the DEAD ... "Human major histocompatibility complex contains a minimum of 19 genes between the complement cluster and HLA-B". Proc Natl Acad ...
"Entrez Gene: BAT4 HLA-B associated transcript 4". Human GPANK1 genome location and GPANK1 gene details page in the UCSC Genome ... A cluster of genes, BAT1-BAT5, has been localized in the vicinity of the genes for TNF alpha and TNF beta. These genes are all ... "Human major histocompatibility complex contains a minimum of 19 genes between the complement cluster and HLA-B". Proc Natl Acad ... 2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome ...
"Entrez Gene: BAT5 HLA-B associated transcript 5". Human ABHD16A genome location and ABHD16A gene details page in the UCSC ... A cluster of genes, BAT1-BAT5, has been localized in the vicinity of the genes for TNF alpha and TNF beta. These genes are all ... "Human major histocompatibility complex contains a minimum of 19 genes between the complement cluster and HLA-B". Proc Natl Acad ... 2004). "Analysis of the Gene-Dense Major Histocompatibility Complex Class III Region and Its Comparison to Mouse". Genome Res. ...
"Entrez Gene: BAT2 HLA-B associated transcript 2". Lehner B, Semple JI, Brown SE, Counsell D, Campbell RD, Sanderson CM (Jan ... A cluster of genes, BAT1-BAT5, has been localized in the vicinity of the genes for TNF alpha and TNF beta. These genes are all ... This gene is also a candidate gene for the development of rheumatoid arthritis. There are two alternatively spliced transcripts ... "Human major histocompatibility complex contains a minimum of 19 genes between the complement cluster and HLA-B". Proc. Natl. ...
"Correlation between HLA-A2 Gene Frequency, Latitude, Ovarian and Prostate Cancer Mortality Rates". Medical Oncology. 21 (1): 49 ... The gene stays off and IL-17 levels plummet.. At the same time, the vitamin D receptor turns on another gene, whose product ... gene have been associated with an increased risk of breast cancer.[3] Women with mutations in the VDR gene had an increased ... By doing so, the receptor occupies a site normally reserved for a protein called NFAT, which is required to turn the gene on. ...
Ganglioside-induced differentiation-associated protein 1 is a protein that in humans is encoded by the GDAP1 gene. This gene ... "Alteration of the HL-A antigenic site in situ". Immunol Commun. 4 (5): 465-76. doi:10.3109/08820137509057334. PMID 54332. " ... Mutations in this gene have been associated with various forms of Charcot-Marie-Tooth Disease and neuropathy. Two transcript ... "Entrez Gene: GDAP1 ganglioside-induced differentiation-associated protein 1". Liu H, Nakagawa T, Kanematsu T, et al. (1999). " ...
"Entrez Gene: CALR calreticulin". Nangalia J, Massie CE, Baxter EJ, Nice FL, Gundem G, Wedge DC, Avezov E, Li J, Kollmann K, ... "HLA-H and associated proteins in patients with hemochromatosis". Molecular Medicine (Cambridge, Mass.). 3 (6): 397-402. PMC ... "Entrez Gene: calreticulin". Mobilferrin at the US National Library of Medicine Medical Subject Headings (MeSH) Beutler E, West ... Thus, calreticulin can act as an important modulator of the regulation of gene transcription by nuclear hormone receptors. ...
... in conjunction with other genes that are involved with immune response processes (TAP1, PSMB8, PSMB9, HLA-DQB1, HLA-DQB2 ... This gene is located in the class II region of the MHC (major histocompatibility complex). Expression of this gene is induced ... HLA-DMA, and HLA-DOA) may form a comprehensive assessment of the clinical outcome in epithelial ovarian carcinoma tumor ... "Nomenclature for factors of the HLA system, 1991. WHO Nomenclature Committee for factors of the HLA system". Tissue Antigens. ...
HLA-C. Minor genes are HLA-E, HLA-F and HLA-G. β2-microglobulin binds with major and minor gene subunits to produce a ... The HLA gene complex resides on a 3 Mbp stretch within chromosome 6p21. HLA genes are highly polymorphic, which means that they ... HLA-DR *α-chain encoded by HLA-DRA locus. *4 β-chains (only 3 possible per person), encoded by HLA-DRB1, DRB3, DRB4, DRB5 loci ... "Frequencies of HLA-A, HLA-B, HLA-DR, and HLA-DQ phenotypes in the United Arab Emirates population". Tissue Antigens. 66 (2): ...
1996). "Complete sequence of the complement C4 gene from the HLA-A1, B8, C4AQ0, C4B1, DR3 haplotype". Immunogenetics. 43 (4): ... genetics of the partially duplicated gene RP located immediately upstream of the complement C4A and the C4B genes in the HLA ... This article on a gene on human chromosome 6 is a stub. You can help Wikipedia by expanding it.. *v ... are present between complement component genes factor B and C4 in the class III region of the HLA". Genomics. 53 (3): 338-47. ...
The only so far reported ligand of KIR2DL4 is the non-classical HLA class 1 gene HLA-G, leading to the inhibition of the ... The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all ... The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb ... This gene is one of the "framework" loci that is present on all haplotypes. Alternative splicing results in multiple transcript ...
"Complete nucleotide sequence of a functional class I HLA gene, HLA-A3: implications for the evolution of HLA genes". EMBO J. 3 ... The next portion (HLA-A or HLA-B) identifies which gene the allele is a modification of. The first two numbers (HLA-A*02) ... The HLA genes are much older. Variation in HLA major antigens is the cause of transplant rejection, but variation at HLA is ... Serotyping can reveal whether an antigen coded by the relevant HLA gene is expressed. An HLA allele coding non-expressed gene ...
1993). "Localization of seven new genes around the HLA-A locus". Hum. Mol. Genet. 2 (1): 55-60. doi:10.1093/hmg/2.1.55. PMID ... "Entrez Gene: TRIM31 tripartite motif-containing 31". Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace ... The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding ... 2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome ...
The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all ... Colonna M, Samaridis J (May 1995). "Cloning of immunoglobulin-superfamily members associated with HLA-C and HLA-B recognition ... "Soluble HLA class I induces NK cell apoptosis upon the engagement of killer-activating HLA class I receptors through FasL-Fas ... The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb ...
Gene. 146 (2): 199-207. doi:10.1016/0378-1119(94)90293-3. PMID 8076819. Wang Z, Cao Y, Albino AP, et al. (1993). "Lack of HLA ... Krangel MS, Orr HT, Strominger JL (1980). "Assembly and maturation of HLA-A and HLA-B antigens in vivo". Cell. 18 (4): 979-91. ... Gattoni-Celli S, Kirsch K, Timpane R, Isselbacher KJ (1992). "Beta 2-microglobulin gene is mutated in a human colon cancer cell ... 1992). "Different length peptides bind to HLA-Aw68 similarly at their ends but bulge out in the middle". Nature. 360 (6402): ...
Malissen, M; Malissen, B; Jordan, BR (1982). "Exon/intron organization and complete nucleotide sequence of an HLA gene". PNAS. ... 1986). "The inducible cytotoxic T-lymphocyte-associated gene transcript CTLA-1 sequence and gene localization to mouse ... 1998). "Gene structure, expression pattern, and biological activity of mouse killer cell activating receptor-associated protein ... gene and described how the TCR recognizes its MHC ligand. The functions of these T cells were also investigated, leading in ...
... within HLA class I region". Biochem Biophys Res Commun. 250 (3): 555-7. doi:10.1006/bbrc.1998.9354. PMID 9784381. "Entrez Gene ... This gene lies within the major histocompatibility complex class I region on chromosome 6. This gene encodes a protein with ... Totaro A, Grifa A, Carella M, Rommens JM, Valentino MA, Roetto A, Zelante L, Gasparini P (Nov 1998). "Cloning of a new gene ( ... Serine/threonine-protein phosphatase 1 regulatory subunit 10 is an enzyme that in humans is encoded by the PPP1R10 gene. ...
"Systematic sequencing of the human HLA-A/HLA-F region: establishment of a cosmid contig and identification of a new gene ... 1993). "Localization of seven new genes around the HLA-A locus". Hum. Mol. Genet. 2 (1): 55-60. doi:10.1093/hmg/2.1.55. PMID ... Protein phosphatase 1 regulatory subunit 11 is an enzyme that in humans is encoded by the PPP1R11 gene. This gene encodes a ... "Entrez Gene: PPP1R11 protein phosphatase 1, regulatory (inhibitor) subunit 11". Amadou C, Ribouchon MT, Mattei MG, et al. (1995 ...
"Epistasis between DSG1 and HLA class II genes in pemphigus foliaceus". Genes Immun. 3 (4): 205-10. doi:10.1038/sj.gene.6363839 ... These desmoglein gene family members are located in a cluster on chromosome 18. The protein encoded by this gene has been ... "Entrez Gene: DSG1 desmoglein 1". Bonné S, Gilbert B, Hatzfeld M, Chen X, Green KJ, van Roy F (April 2003). "Defining desmosomal ... Wang Y, Amagai M, Minoshima S (1994). "The human genes for desmogleins (DSG1 and DSG3) are located in a small region on ...
HLA- linked olfactory receptor genes can therefore provide a possible mechanism for detecting HLA- specific odours. Men and ... HLA refers to the human form of MHC, and is a gene complex which encodes the MHC. There is increasing evidence for a ... Over thirty olfactory receptor genes have been located at the HLA class I region, which presents peptides from inside the cell ... "Polymorphisms in the HLA-linked olfactory receptor genes in the Hutterites". Human Immunology. 61 (7): 711-717. doi:10.1016/ ...
Im DS, Heise CE, Ancellin N, O'Dowd BF, Shei GJ, Heavens RP, Rigby MR, Hla T, Mandala S, McAllister G, George SR, Lynch KR (May ... Sphingosine-1-phosphate receptor 5 also known as S1PR5 is a human gene which encodes a G protein-coupled receptor which binds ... Hla T (Apr 2001). "Sphingosine 1-phosphate receptors". Prostaglandins. 64 (1-4): 135-142. doi:10.1016/s0090-6980(01)00109-5. ... Takeda S, Kadowaki S, Haga T, Takaesu H, Mitaku S (Jun 2002). "Identification of G protein-coupled receptor genes from the ...
HLA-A, HLA-B, or HLA-C) increase the risk of graft rejection. A mismatch of an HLA Type II gene (i.e. HLA-DR, or HLA-DQB1) ... The HLA genes fall in two categories (Type I and Type II). In general, mismatches of the Type-I genes (i.e. ... as members of the same ethnic group are more likely to have matching genes, including the genes for HLA.[24] ... Matching is performed on the basis of variability at three or more loci of the HLA gene, and a perfect match at these loci is ...
In West Africa an HLA class I antigen (HLA Bw53) and an HLA class II haplotype (DRB1*13OZ-DQB1*0501) are independently ... The HbS gene defect is a mutation of a single nucleotide (A to T) of the β-globin gene replacing the amino acid glutamic acid ... To balance this loss of sickle-cell genes, a mutation rate of 1:10.2 per gene per generation would be necessary. This is about ... locus (gene or chromosome) - the specific location of a gene or DNA sequence or position on a chromosome ...
The different HLA gene products migrate with disparate, though characteristic, isoelectric points. ... HLA-A*0201 heavy chain (HLA-A2), with the mouse H-2 Kb signal sequence replacing its own (Story et al. 1999), was cloned into ... Anti-heavy chain serum (αHC) was made by injecting rabbits with the luminal domains (amino acids 1-275) of both HLA-A2 and HLA- ... 1994) Strategy for epitope tagging the protein-coding region of any gene. Biotechniques. 17:560-565, pmid:7529515.. ...
Interestingly, recent evidence suggests HLA-G expression is largely mediated by genetic polymorphisms found in the gene. ... Given that HLA-G may be expressed by the donor allograft, our objective was to evaluate HLA-G donor/recipient polymorphism ... HLA-G may have a role in therapeutic/diagnostic strategies against cancer. Identifying relevant HLA-G polymorphisms may warrant ... Human leukocyte antigen-G (HLA-G) is an immune checkpoint molecule which functions to dampen the immune response. HLA-G ...
The present study can therefore be valuable for enriching the ethnical gene information resources of the KIR gene pool, for ... The present study can therefore be valuable for enriching the ethnical gene information resources of the KIR gene pool, for ... The present study can therefore be valuable for enriching the ethnical gene information resources of the KIR gene pool, for ... The present study can therefore be valuable for enriching the ethnical gene information resources of the KIR gene pool, for ...
Raznolikost gena HLA-DRB4 u Hrvatskoj. Naslov (engleski). Polymorphism of HLA-DRB4 gene in Croatia. ... Among HLA-DRB1*04-DQB1 haplotypes the most present was DRB4*01:03 allele (86.7%). Among HLA-DRB1*07:01 positive haplotypes a ... U haplotipovima HLA-DRB1*04-DQB1 najčešći prisutni alel je bio DRB4*01:03 (86,7%). Među HLA-DRB1*07:01 pozitivnim haplotipovima ... In this study the polymorphism of HLA-DRB4 alleles and HLA-DRB1-DRB4 haplotypes among Croatian cadaveric organ donors (N = 144 ...
HLA class II histocompatibility antigen, DRB3-1 beta chain is a protein that in humans is encoded by the HLA-DRB3 gene. The ... HLA-DR "Human PubMed Reference:". "Entrez Gene: HLA-DRB3 major histocompatibility complex, class II, DR beta 3". Germain RN ( ... Gorski J, Mach B (1986). "Polymorphism of human Ia antigens: gene conversion between two DR beta loci results in a new HLA-D/DR ... 1989). "Molecular analysis of the HLA class II genes in two DRw6-related haplotypes, DRw13 DQw1 and DRw14 DQw3". J. Immunol. ...
... is most increased by two HLA haplotypes involving variations of the HLA-DQA1 and HLA-DQB1 genes and another HLA gene called HLA ... The HLA-DQA1 gene is part of a family of genes called the human leukocyte antigen (HLA) complex. The HLA complex helps the ... 01 or HLA-DQA1*05:05 bound to the protein produced from HLA-DQB1 gene variants known as HLA-DQB1*02:01 or HLA-DQB1*02:02. The ... The HLA-DQA1 gene belongs to a group of MHC genes called MHC class II. MHC class II genes provide instructions for making ...
Gene target information for HLA-B - major histocompatibility complex, class I, B (human). Find diseases associated with this ...
Our data supports previous indications that HLA genes or HLA-linked genes may be associated with variation in fetal growth (9 ... Genes in the HLA complex encode molecules involved in rejection of nonself tissue, and antibodies to fetal HLA molecules have ... Because there are indications that genes in the HLA complex are associated with fetal growth (9), we tested whether HLA-DQ ... It is probably premature to conclude that there is a causal link between HLA-DQ genes and birth weight, but our results ...
The HLA-DRB1 gene is part of a family of genes called the human leukocyte antigen (HLA) complex. The HLA complex helps the ... is most increased by two specific combinations of variations of the HLA-DRB1 gene and other HLA genes called HLA-DQA1 and HLA- ... The HLA-DRB1 gene belongs to a group of MHC genes called MHC class II. MHC class II genes provide instructions for making ... Combinations of variations in the HLA-DRB1 gene and other HLA genes affect the risk of type 1 diabetes. Type 1 diabetes is ...
Complete information for HLA-P gene (Pseudogene), Major Histocompatibility Complex, Class I, P (Pseudogene), including: ... for HLA-P Gene Orthologs for HLA-P Gene Evolution for HLA-P Gene. ENSEMBL:. Gene Tree for HLA-P (if available). TreeFam:. Gene ... No data available for DME Specific Peptides for HLA-P Gene Domains & Families for HLA-P Gene Gene Families for HLA-P Gene. HGNC ... Summaries for HLA-P Gene GeneCards Summary for HLA-P Gene HLA-P (Major Histocompatibility Complex, Class I, P (Pseudogene)) is ...
Complete information for HLA-DRB6 gene (Pseudogene), Major Histocompatibility Complex, Class II, DR Beta 6 (Pseudogene), ... HLA-DRB1 HLA-DQA2 HLA-DRB6 HLA-DQB1 HLA-DRB5 HLA-DQB2 HLA-DQA1 CYP21A1P HLA-DQB1-AS1 HLA-DPB1 ... HLA-DRB1 HLA-DRB5 HLA-DQA1 HLA-DQA2 HLA-DRB6 C4A HLA-DQB2 HLA-DOB HLA-DQB1 HLA-DMA ... HLA-DQA1 HLA-DQB1 HLA-DQA2 HLA-DRB1 HLA-DQB2 HLA-DRB5 HLA-DRB6 PPT2 CYP21A1P HLA-DQB1-AS1 ...
Gene View The Gene Browser allows to navigate the human genome and investigate the relationship between PDB entries and genes. ... HLA-A Gene Structure. Chromosome: chr6_mcf_hap5 Genbank ID: NM_002116 Orientation: + Length coding sequence : 1095 nucleotides ... Number of PDB entities (unique chains) for this gene: 328 View list of all current human gene IDs ... Gene. This track represents the gene-structure on the genome. White boxes represent UTRs (untranslated regions). Orange: ...
... based assay to genotype 194 UC patients and 216 control individuals for 14 KIR genes, the HLA-Cw ligand epitopes of the KIR2D ... HLA) ligand on target cells. Recent genetic association studies have implicated KIR genotype in the development of several ... Logistic regression analysis revealed a protective effect conferred by KIR2DL3 in the presence of its ligand HLA-Cw group 1 (P= ... 0.019). These results suggest that KIR genotype and HLA ligand interaction may contribute to the genetic susceptibility of UC. ...
A total of 184 neonates completed the HLA-DR and -DQ genotyping. The frequencies of HLA-DR and -DQ genes, maternal ... THE ASSOCIATION BETWEEN HLA-DR, -DQ GENES AND SUSCEPTIBILITY TO ATOPY IN A BIRTH COHORT. Lin, Y C.*†; Wen, H R.†; Lee, Y L.†; ... Our aim is to determine the association between HLA-DR and -DQ genes and susceptibility to atopy in a birth cohort at one year ... Home , September 2005 - Volume 16 - Issue 5 , THE ASSOCIATION BETWEEN HLA-DR, -DQ GENES AND SUSCEPTIBILITY... ...
HLA-DR3-DQ2 without HLA-DR7-DQ2 was present in 62.6%, HLA-DR7-DQ2 without HLA-DR3-DQ2 was present in 16.5% and HLA-DR4-DQ8 ... DRB3; HLA-DPB1; HLA-DR1B; HLA-DR3B. Summary. HLA-DRB3 belongs to the HLA class II beta chain paralogues. This class II molecule ... GeneRIFs: Gene References Into Functions Whats a GeneRIF? * In contrast to HLA-DRB4*01:01P, the inheritance of HLA-DRB3*01:01 ... HLA DRB3. HLA class II histocompatibility antigen, DR beta 3 chain. MHC class II HLA-DR beta 3 chain. MHC class II antigen DR ...
There is one called the HLA-DRB1 gene that seems most promising, among other human leukocyte antigen (HLA) genes. ... Rheumatoid Arthritis: HLA Genes Reveal Important Information. By Jody Smith HERWriter Average Select rating. Poor. Fair. ... The HLA gene complex helps the immune system be able to distinguish between the bodys proteins and the proteins made by toxins ... The study showed that the gene HLA-DRB1 was linked with both severity of RA, and with response to treatment in these groups. ...
Gene namesi. Name:HLA-DQB1Imported. Automatic assertion inferred from database entriesi ... p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source ... Four distinct tokens exist: Name, Synonyms, Ordered locus names and ORF names.,p>,a href=/help/gene_name target=_top ... tr,Q30003,Q30003_HUMAN Lymphocyte antigen (Fragment) OS=Homo sapiens OX=9606 GN=HLA-DQB1 PE=4 SV=1 ...
HLA-DQ beta gene contributes to susceptibility and resistance to insulin-dependent diabetes mellitus.. Todd JA1, Bell JI, ... insulin-dependent diabetes mellitus maps to the region of chromosome 6 that contains the highly polymorphic HLA class II genes ... Analysis of DNA sequences from diabetics indicates that alleles of HLA-DQ beta determine both disease susceptibility and ...
Heterozygosity at individual amino acid sites: extremely high levels for HLA-A and -B genes.. P W Hedrick, T S Whittam, and P ... Multidisease gene therapy in mice. A single formulation combining two gene therapies treated an array of age-related disorders ... Heterozygosity at individual amino acid sites: extremely high levels for HLA-A and -B genes. ... Heterozygosity at individual amino acid sites: extremely high levels for HLA-A and -B genes. ...
They report that genetic variants in STAT4 and HLA-DQ genes confer risk of HBV-HCC. ... Genetic variants in STAT4 and HLA-DQ genes confer risk of hepatitis B virus-related hepatocellular carcinoma. *De-Ke Jiang1. ... Regulation of major histocompatibility complex class II gene expression, genetic variation and disease. . Genes Immun. 11, 99- ... Primary biliary cirrhosis associated with HLA, IL12A, and IL12RB2 variants. . N. Engl. J. Med. 360, 2544-2555 (2009). ...
Gene namesi. Name:HLA-DRB1Imported. ,p>Information which has been imported from another database using automatic procedures.,/p ... p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source ... tr,F4YZW3,F4YZW3_HUMAN MHC class II antigen (Fragment) OS=Homo sapiens OX=9606 GN=HLA-DRB1 PE=4 SV=1 ... Four distinct tokens exist: Name, Synonyms, Ordered locus names and ORF names.,p>,a href=/help/gene_name target=_top ...
TAP2 is a gene, located between HLA-DP and HLA-DQ, whose products form a transporter molecule involved in endogenous antigen ... Our data show that there is no significant correlation between TAP2 and/or HLA-DP gene polymorphism and psoriasis type I and/or ... Analysis of TAP2 and HLA-DP gene polymorphism in psoriasis. Fakler, JW ... We have previously shown that type I but not type II psoriasis is associated with the HLA-DRB1*0701/2, -DQA1*0201, -DQB1*0303 ...
Gene interaction at HLA-DQ enhances autoantibody production in primary Sjogrens syndrome ... Gene interaction at HLA-DQ enhances autoantibody production in primary Sjogrens syndrome ... Gene interaction at HLA-DQ enhances autoantibody production in primary Sjogrens syndrome ... Gene interaction at HLA-DQ enhances autoantibody production in primary Sjogrens syndrome ...
Additionally, HLA-DQB1 and DPB1 polymorphism was assessed in samples selected based on their HLA and cytokine gene profiles. ... Identification of immunogenetic factors (HLA and cytokine gene polymorphisms) involved in successful aging. Genetic ... Identification of immunogenetic factors (HLA and cytokine gene polymorphisms) involved in successful aging ... The following genetic markers were analyzed: HLA class I (A, B) and class II (DRB) loci, IL-2, IL-6, IL-10, IL-12B, IFNã, TNF-A ...
Two types of HLA-DQ2 molecules exist, termed HLA-DQ2.5 and HLA-DQ2.2. Whereas HLA-DQ2.5 predisposes to celiac disease, HLA- ... HLA-DR3DQ2), Douglas and Brussel (HLA-DR3/7DQ2), FK (HLA-DR3/4DQ2/8), MHG (HLADR3/4DQ2/3), Pitout and EKR (HLA DR7DQ2), CJO ( ... known to bind specifically to both HLA-DQ2.5 and HLA-DQ2.2 (6), bound strongly to HLA-DQ isolated from both HLA-DQ2-homozygous ... HLA-DQ2 Gene Dose Determines the Level of Gluten-Specific T Cell Stimulation. Epidemiological studies have shown that HLA-DQ2- ...
  • All individuals were typed positive for the four framework loci KIR3DL3, 2DL4, 3DL2 and KIR3DP1, while activating genes (KIR2DS1, 2DS2, 2DS3, 2DS5 and KIR3DS1) indicated some variation in this population. (elsevier.com)
  • KIR gene frequencies and haplotype distributions have been shown to differ significantly between populations from different geographical regions and ethnic origins, which relates to functional variations in the immune response. (elsevier.com)
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