An HLA-DR antigen which is associated with HLA-DRB1 CHAINS encoded by DRB1*03 alleles.
A subclass of HLA-D antigens that consist of alpha and beta chains. The inheritance of HLA-DR antigens differs from that of the HLA-DQ ANTIGENS and HLA-DP ANTIGENS.
Antigens determined by leukocyte loci found on chromosome 6, the major histocompatibility loci in humans. They are polypeptides or glycoproteins found on most nucleated cells and platelets, determine tissue types for transplantation, and are associated with certain diseases.
An HLA-DR antigen which is associated with HLA-DRB1 CHAINS encoded by DRB1*04 alleles.
Large, transmembrane, non-covalently linked glycoproteins (alpha and beta). Both chains can be polymorphic although there is more structural variation in the beta chains. The class II antigens in humans are called HLA-D ANTIGENS and are coded by a gene on chromosome 6. In mice, two genes named IA and IE on chromosome 17 code for the H-2 antigens. The antigens are found on B-lymphocytes, macrophages, epidermal cells, and sperm and are thought to mediate the competence of and cellular cooperation in the immune response. The term IA antigens used to refer only to the proteins encoded by the IA genes in the mouse, but is now used as a generic term for any class II histocompatibility antigen.
Substances that are recognized by the immune system and induce an immune reaction.
Human immune-response or Class II antigens found mainly, but not exclusively, on B-lymphocytes and produced from genes of the HLA-D locus. They are extremely polymorphic families of glycopeptides, each consisting of two chains, alpha and beta. This group of antigens includes the -DR, -DQ and -DP designations, of which HLA-DR is most studied; some of these glycoproteins are associated with certain diseases, possibly of immune etiology.
HLA-DR antigen subtypes that have been classified according to their affinity to specific ANTIBODIES. The DNA sequence analyses of HLA-DR ALPHA-CHAINS and HLA-DR BETA-CHAINS has for the most part revealed the specific alleles that are responsible for each serological subtype.
Identification of the major histocompatibility antigens of transplant DONORS and potential recipients, usually by serological tests. Donor and recipient pairs should be of identical ABO blood group, and in addition should be matched as closely as possible for HISTOCOMPATIBILITY ANTIGENS in order to minimize the likelihood of allograft rejection. (King, Dictionary of Genetics, 4th ed)
Genetic loci in the vertebrate major histocompatibility complex that encode polymorphic products which control the immune response to specific antigens. The genes are found in the HLA-D region in humans and in the I region in mice.
Class I human histocompatibility (HLA) surface antigens encoded by more than 30 detectable alleles on locus B of the HLA complex, the most polymorphic of all the HLA specificities. Several of these antigens (e.g., HLA-B27, -B7, -B8) are strongly associated with predisposition to rheumatoid and other autoimmune disorders. Like other class I HLA determinants, they are involved in the cellular immune reactivity of cytolytic T lymphocytes.
A group of the D-related HLA antigens found to differ from the DR antigens in genetic locus and therefore inheritance. These antigens are polymorphic glycoproteins comprising alpha and beta chains and are found on lymphoid and other cells, often associated with certain diseases.
Substances elaborated by bacteria that have antigenic activity.
A broad specificity HLA-DR antigen that is associated with HLA-DRB1 CHAINS encoded by DRB1*01:15 and DRB1*01:16 alleles.
Proteins, glycoprotein, or lipoprotein moieties on surfaces of tumor cells that are usually identified by monoclonal antibodies. Many of these are of either embryonic or viral origin.
Measure of histocompatibility at the HL-A locus. Peripheral blood lymphocytes from two individuals are mixed together in tissue culture for several days. Lymphocytes from incompatible individuals will stimulate each other to proliferate significantly (measured by tritiated thymidine uptake) whereas those from compatible individuals will not. In the one-way MLC test, the lymphocytes from one of the individuals are inactivated (usually by treatment with MITOMYCIN or radiation) thereby allowing only the untreated remaining population of cells to proliferate in response to foreign histocompatibility antigens.
Antigens on surfaces of cells, including infectious or foreign cells or viruses. They are usually protein-containing groups on cell membranes or walls and may be isolated.
Substances elaborated by viruses that have antigenic activity.
Antibodies produced by a single clone of cells.
A HLA-DR antigen that is associated with HLA-DRB1 CHAINS encoded by DRB1*07 alleles.
Drying and inflammation of the conjunctiva as a result of insufficient lacrimal secretion. When found in association with XEROSTOMIA and polyarthritis, it is called SJOGREN'S SYNDROME.
An HLA-DR antigen associated with HLA-DRB1 CHAINS that are encoded by DRB1*01 alleles.
A variable mixture of the mono- and disodium salts of gold thiomalic acid used mainly for its anti-inflammatory action in the treatment of rheumatoid arthritis. It is most effective in active progressive rheumatoid arthritis and of little or no value in the presence of extensive deformities or in the treatment of other forms of arthritis.
Any part or derivative of any protozoan that elicits immunity; malaria (Plasmodium) and trypanosome antigens are presently the most frequently encountered.
A subtype of HLA-DRB beta chains that includes over one hundred allele variants. The HLA-DRB1 subtype is associated with several of the HLA-DR SEROLOGICAL SUBTYPES.
Sites on an antigen that interact with specific antibodies.
Polyomavirus antigens which cause infection and cellular transformation. The large T antigen is necessary for the initiation of viral DNA synthesis, repression of transcription of the early region and is responsible in conjunction with the middle T antigen for the transformation of primary cells. Small T antigen is necessary for the completion of the productive infection cycle.
Differentiation antigens residing on mammalian leukocytes. CD stands for cluster of differentiation, which refers to groups of monoclonal antibodies that show similar reactivity with certain subpopulations of antigens of a particular lineage or differentiation stage. The subpopulations of antigens are also known by the same CD designation.
Substances of fungal origin that have antigenic activity.
Polymorphic class I human histocompatibility (HLA) surface antigens present on almost all nucleated cells. At least 20 antigens have been identified which are encoded by the A locus of multiple alleles on chromosome 6. They serve as targets for T-cell cytolytic responses and are involved with acceptance or rejection of tissue/organ grafts.
Any part or derivative of a helminth that elicits an immune reaction. The most commonly seen helminth antigens are those of the schistosomes.
The major group of transplantation antigens in the mouse.
Variant forms of the same gene, occupying the same locus on homologous CHROMOSOMES, and governing the variants in production of the same gene product.
Antigenic determinants recognized and bound by the T-cell receptor. Epitopes recognized by the T-cell receptor are often located in the inner, unexposed side of the antigen, and become accessible to the T-cell receptors after proteolytic processing of the antigen.
Membrane glycoproteins consisting of an alpha subunit and a BETA 2-MICROGLOBULIN beta subunit. In humans, highly polymorphic genes on CHROMOSOME 6 encode the alpha subunits of class I antigens and play an important role in determining the serological specificity of the surface antigen. Class I antigens are found on most nucleated cells and are generally detected by their reactivity with alloantisera. These antigens are recognized during GRAFT REJECTION and restrict cell-mediated lysis of virus-infected cells.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
A glycoprotein that is secreted into the luminal surface of the epithelia in the gastrointestinal tract. It is found in the feces and pancreaticobiliary secretions and is used to monitor the response to colon cancer treatment.
Those proteins recognized by antibodies from serum of animals bearing tumors induced by viruses; these proteins are presumably coded for by the nucleic acids of the same viruses that caused the neoplastic transformation.
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
A group of antigens that includes both the major and minor histocompatibility antigens. The former are genetically determined by the major histocompatibility complex. They determine tissue type for transplantation and cause allograft rejections. The latter are systems of allelic alloantigens that can cause weak transplant rejection.
Molecules on the surface of T-lymphocytes that recognize and combine with antigens. The receptors are non-covalently associated with a complex of several polypeptides collectively called CD3 antigens (ANTIGENS, CD3). Recognition of foreign antigen and the major histocompatibility complex is accomplished by a single heterodimeric antigen-receptor structure, composed of either alpha-beta (RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA) or gamma-delta (RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA) chains.
A critical subpopulation of T-lymphocytes involved in the induction of most immunological functions. The HIV virus has selective tropism for the T4 cell which expresses the CD4 phenotypic marker, a receptor for HIV. In fact, the key element in the profound immunosuppression seen in HIV infection is the depletion of this subset of T-lymphocytes.
A specific HLA-A surface antigen subtype. Members of this subtype contain alpha chains that are encoded by the HLA-A*02 allele family.
A subtype of DIABETES MELLITUS that is characterized by INSULIN deficiency. It is manifested by the sudden onset of severe HYPERGLYCEMIA, rapid progression to DIABETIC KETOACIDOSIS, and DEATH unless treated with insulin. The disease may occur at any age, but is most common in childhood or adolescence.
The genetic constitution of individuals with respect to one member of a pair of allelic genes, or sets of genes that are closely linked and tend to be inherited together such as those of the MAJOR HISTOCOMPATIBILITY COMPLEX.
Lymphocytes responsible for cell-mediated immunity. Two types have been identified - cytotoxic (T-LYMPHOCYTES, CYTOTOXIC) and helper T-lymphocytes (T-LYMPHOCYTES, HELPER-INDUCER). They are formed when lymphocytes circulate through the THYMUS GLAND and differentiate to thymocytes. When exposed to an antigen, they divide rapidly and produce large numbers of new T cells sensitized to that antigen.
Nuclear antigen with a role in DNA synthesis, DNA repair, and cell cycle progression. PCNA is required for the coordinated synthesis of both leading and lagging strands at the replication fork during DNA replication. PCNA expression correlates with the proliferation activity of several malignant and non-malignant cell types.
IMMUNOGLOBULINS on the surface of B-LYMPHOCYTES. Their MESSENGER RNA contains an EXON with a membrane spanning sequence, producing immunoglobulins in the form of type I transmembrane proteins as opposed to secreted immunoglobulins (ANTIBODIES) which do not contain the membrane spanning segment.
A glycoprotein that is a kallikrein-like serine proteinase and an esterase, produced by epithelial cells of both normal and malignant prostate tissue. It is an important marker for the diagnosis of prostate cancer.
The lipopolysaccharide-protein somatic antigens, usually from gram-negative bacteria, important in the serological classification of enteric bacilli. The O-specific chains determine the specificity of the O antigens of a given serotype. O antigens are the immunodominant part of the lipopolysaccharide molecule in the intact bacterial cell. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)
A chronic systemic disease, primarily of the joints, marked by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. Etiology is unknown, but autoimmune mechanisms have been implicated.
A serine protease that catalyses the release of an N-terminal dipeptide. Several biologically-active peptides have been identified as dipeptidyl peptidase 4 substrates including INCRETINS; NEUROPEPTIDES; and CHEMOKINES. The protein is also found bound to ADENOSINE DEAMINASE on the T-CELL surface and is believed to play a role in T-cell activation.
Differentiation antigens found on thymocytes and on cytotoxic and suppressor T-lymphocytes. CD8 antigens are members of the immunoglobulin supergene family and are associative recognition elements in MHC (Major Histocompatibility Complex) Class I-restricted interactions.
A trisaccharide antigen expressed on glycolipids and many cell-surface glycoproteins. In the blood the antigen is found on the surface of NEUTROPHILS; EOSINOPHILS; and MONOCYTES. In addition, CD15 antigen is a stage-specific embryonic antigen.
An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.
Carbohydrate antigens expressed by malignant tissue. They are useful as tumor markers and are measured in the serum by means of a radioimmunoassay employing monoclonal antibodies.
Serological reactions in which an antiserum against one antigen reacts with a non-identical but closely related antigen.
The major immunoglobulin isotype class in normal human serum. There are several isotype subclasses of IgG, for example, IgG1, IgG2A, and IgG2B.
Sets of cell surface antigens located on BLOOD CELLS. They are usually membrane GLYCOPROTEINS or GLYCOLIPIDS that are antigenically distinguished by their carbohydrate moieties.
Morphologic alteration of small B LYMPHOCYTES or T LYMPHOCYTES in culture into large blast-like cells able to synthesize DNA and RNA and to divide mitotically. It is induced by INTERLEUKINS; MITOGENS such as PHYTOHEMAGGLUTININS, and by specific ANTIGENS. It may also occur in vivo as in GRAFT REJECTION.
Complex of at least five membrane-bound polypeptides in mature T-lymphocytes that are non-covalently associated with one another and with the T-cell receptor (RECEPTORS, ANTIGEN, T-CELL). The CD3 complex includes the gamma, delta, epsilon, zeta, and eta chains (subunits). When antigen binds to the T-cell receptor, the CD3 complex transduces the activating signals to the cytoplasm of the T-cell. The CD3 gamma and delta chains (subunits) are separate from and not related to the gamma/delta chains of the T-cell receptor (RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA).
Those hepatitis B antigens found on the surface of the Dane particle and on the 20 nm spherical and tubular particles. Several subspecificities of the surface antigen are known. These were formerly called the Australia antigen.
A latent susceptibility to disease at the genetic level, which may be activated under certain conditions.
Class I human histocompatibility (HLA) antigens encoded by a small cluster of structural genes at the C locus on chromosome 6. They have significantly lower immunogenicity than the HLA-A and -B determinants and are therefore of minor importance in donor/recipient crossmatching. Their primary role is their high-risk association with certain disease manifestations (e.g., spondylarthritis, psoriasis, multiple myeloma).
The property of antibodies which enables them to react with some ANTIGENIC DETERMINANTS and not with others. Specificity is dependent on chemical composition, physical forces, and molecular structure at the binding site.
Transmembrane proteins that form the beta subunits of the HLA-DQ antigens.
Established cell cultures that have the potential to propagate indefinitely.
55-kDa antigens found on HELPER-INDUCER T-LYMPHOCYTES and on a variety of other immune cell types. CD4 antigens are members of the immunoglobulin supergene family and are implicated as associative recognition elements in MAJOR HISTOCOMPATIBILITY COMPLEX class II-restricted immune responses. On T-lymphocytes they define the helper/inducer subset. CD4 antigens also serve as INTERLEUKIN-15 receptors and bind to the HIV receptors, binding directly to the HIV ENVELOPE PROTEIN GP120.
High-molecular weight glycoproteins uniquely expressed on the surface of LEUKOCYTES and their hemopoietic progenitors. They contain a cytoplasmic protein tyrosine phosphatase activity which plays a role in intracellular signaling from the CELL SURFACE RECEPTORS. The CD45 antigens occur as multiple isoforms that result from alternative mRNA splicing and differential usage of three exons.
Test for tissue antigen using either a direct method, by conjugation of antibody with fluorescent dye (FLUORESCENT ANTIBODY TECHNIQUE, DIRECT) or an indirect method, by formation of antigen-antibody complex which is then labeled with fluorescein-conjugated anti-immunoglobulin antibody (FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT). The tissue is then examined by fluorescence microscopy.
Molecules on the surface of B- and T-lymphocytes that recognize and combine with specific antigens.
The processes triggered by interactions of ANTIBODIES with their ANTIGENS.
Lymphoid cells concerned with humoral immunity. They are short-lived cells resembling bursa-derived lymphocytes of birds in their production of immunoglobulin upon appropriate stimulation.
Antigens of the virion of the HEPATITIS B VIRUS or the Dane particle, its surface (HEPATITIS B SURFACE ANTIGENS), core (HEPATITIS B CORE ANTIGENS), and other associated antigens, including the HEPATITIS B E ANTIGENS.
The production of ANTIBODIES by proliferating and differentiated B-LYMPHOCYTES under stimulation by ANTIGENS.
Immunized T-lymphocytes which can directly destroy appropriate target cells. These cytotoxic lymphocytes may be generated in vitro in mixed lymphocyte cultures (MLC), in vivo during a graft-versus-host (GVH) reaction, or after immunization with an allograft, tumor cell or virally transformed or chemically modified target cell. The lytic phenomenon is sometimes referred to as cell-mediated lympholysis (CML). These CD8-positive cells are distinct from NATURAL KILLER CELLS and NATURAL KILLER T-CELLS. There are two effector phenotypes: TC1 and TC2.
Glycoproteins expressed on cortical thymocytes and on some dendritic cells and B-cells. Their structure is similar to that of MHC Class I and their function has been postulated as similar also. CD1 antigens are highly specific markers for human LANGERHANS CELLS.
Serum that contains antibodies. It is obtained from an animal that has been immunized either by ANTIGEN injection or infection with microorganisms containing the antigen.
Deliberate stimulation of the host's immune response. ACTIVE IMMUNIZATION involves administration of ANTIGENS or IMMUNOLOGIC ADJUVANTS. PASSIVE IMMUNIZATION involves administration of IMMUNE SERA or LYMPHOCYTES or their extracts (e.g., transfer factor, immune RNA) or transplantation of immunocompetent cell producing tissue (thymus or bone marrow).
A specific HLA-A surface antigen subtype. Members of this subtype contain alpha chains that are encoded by the HLA-A*01 allele family.
Immunoglobulins produced in a response to BACTERIAL ANTIGENS.
Antigens expressed primarily on the membranes of living cells during sequential stages of maturation and differentiation. As immunologic markers they have high organ and tissue specificity and are useful as probes in studies of normal cell development as well as neoplastic transformation.
Antigens expressed on the cell membrane of T-lymphocytes during differentiation, activation, and normal and neoplastic transformation. Their phenotypic characterization is important in differential diagnosis and studies of thymic ontogeny and T-cell function.
A specific HLA-B surface antigen subtype. Members of this subtype contain alpha chains that are encoded by the HLA-B*07 allele family.
A specific HLA-B surface antigen subtype. Members of this subtype contain alpha chains that are encoded by the HLA-B*27 allele family.
A specific HLA-B surface antigen subtype. Members of this subtype contain alpha chains that are encoded by the HLA-B*08 allele family.
The genetic region which contains the loci of genes which determine the structure of the serologically defined (SD) and lymphocyte-defined (LD) TRANSPLANTATION ANTIGENS, genes which control the structure of the IMMUNE RESPONSE-ASSOCIATED ANTIGENS, HUMAN; the IMMUNE RESPONSE GENES which control the ability of an animal to respond immunologically to antigenic stimuli, and genes which determine the structure and/or level of the first four components of complement.

HLA-DR expression and soluble HLA-DR levels in septic patients after trauma. (1/3769)

OBJECTIVE: To determine if cellular and soluble HLA-DR molecules may be relevant in severely injured patients for the development of gram-positive or gram-negative sepsis. SUMMARY BACKGROUND DATA: HLA-DR molecules play a central role in the specific immune response to infection. The reduced HLA-DR expression on monocytes is considered to correlate with infectious complications and the development of sepsis. Data on the role of HLA-DR expression on T cells and soluble HLA-DR molecules are rare. METHODS: HLA-DR expression on monocytes and T cells was measured by flow cytometry. Plasma levels of soluble HLA-DR were studied by enzyme-linked immunosorbent assay. RESULTS: HLA-DR expression on circulating T cells, calculated as mean fluorescence intensity in channels, was reduced at day 1 after admission in 20 patients with subsequent severe sepsis compared with 46 patients without sepsis. The septic patients immediately after trauma had significantly lower soluble HLA-DR plasma levels than the nonseptic patients. At day 2 after admission, HLA-DR expression on monocytes was significantly lower in the severe sepsis group than in the patients without sepsis, and lasted until day 14 after injury. CONCLUSIONS: In severely injured patients, decreased levels of cellular and soluble HLA-DR appear as early indicators of an immune deviation associated with the development of severe sepsis. Moreover, immune alterations of different cell types may promote distinct kinds of septicemia.  (+info)

Specificity and function of immunogenic peptides from the 35-kilodalton protein of Mycobacterium leprae. (2/3769)

We identified a T-cell determinant of the 35-kDa antigen of Mycobacterium leprae which is discriminatory against cross-sensitization by its closely related homologue in Mycobacterium avium. From synthetic peptides covering the entire sequence, those with the highest affinity and permissive binding to purified HLA-DR molecules were evaluated for the stimulation of proliferation of peripheral blood mononuclear cells (PBMCs) from leprosy patients and healthy sensitized controls. Responses to the peptide pair 206-224, differing by four residues between M. leprae and M. avium, involved both species-specific and cross-reactive T cells. Lymph node cell proliferation in HLA-DRB1*01 transgenic mice was reciprocally species specific, but only the response to the M. leprae peptide in the context of DR1 was immunodominant. Of the cytokines in human PBMC cultures, gamma interferon production was negligible, while interleukin 10 (IL-10) responses in both patients and controls were more pronounced. IL-10 was most frequently induced by the shared 241-255 peptide, indicating that environmental cross-sensitization may skew the response toward a potentially pathogenic cytokine phenotype.  (+info)

Expression of B7 costimulatory molecules by salivary gland epithelial cells in patients with Sjogren's syndrome. (3/3769)

OBJECTIVE: To investigate the expression of B7 costimulatory molecules in the lymphoepithelial lesions of salivary gland (SG) biopsy tissues and in SG epithelial cell lines derived from patients with Sjogren's syndrome (SS). METHODS: B7.1 and B7.2 protein expression was studied by immunohistochemistry in minor SGs obtained from 11 patients with SS and 10 disease control patients with nonspecific sialadenitis and in cultured SG epithelial cell lines obtained from minor SGs from 15 SS patients and 15 control patients. B7.1 and B7.2 messenger RNA (mRNA) expression by SG epithelial cell lines was examined by reverse transcription-polymerase chain reaction (RT-PCR). RESULTS: In biopsy tissues from SS patients, but not control patients, ductal and acinar epithelial cells showed increased expression of both B7.1 and B7.2. Intense spontaneous B7.1 protein expression (as well as HLA-ABC, but not B7.2 or HLA-DR) was also found in 73% of SG epithelial cell lines from SS patients versus 13% of those from control patients (P < 0.01). Interferon-y treatment induced, or up-regulated, B7.1, B7.2, and HLA-DR expression in all SG epithelial cell lines tested. B7.1 and B7.2 expression by SG epithelial cell lines was also verified at the mRNA level by RT-PCR. CONCLUSION: Human SG epithelia are intrinsically capable of expressing B7 proteins upon activation. In SS patients, the expression of B7 molecules by SG epithelial tissues and by SG epithelial cell lines indicates the activated status of SG epithelial cells in this disorder and, possibly, their capacity for presenting antigens to T cells.  (+info)

Disease pattern in cranial and large-vessel giant cell arteritis. (4/3769)

OBJECTIVE: To identify variables that distinguish large-vessel giant cell arteritis (GCA) with subclavian/axillary/brachial artery involvement from cranial GCA. METHODS: Seventy-four case patients with subclavian/axillary GCA diagnosed by angiography and 74 control patients with temporal artery biopsy-proven GCA without large vessel involvement matched for the date of first diagnosis were identified. Pertinent initial symptoms, time delay until diagnosis, and clinical symptoms, as well as clinical and laboratory findings at the time of diagnosis, were recorded by retrospective chart review. Expression of cytokine messenger RNA in temporal artery tissue from patients with large-vessel and cranial GCA was determined by semiquantitative polymerase chain reaction analysis. Distribution of disease-associated HLA-DRB1 alleles in patients with aortic arch syndrome and cranial GCA was assessed. RESULTS: The clinical presentation distinguished patients with large-vessel GCA from those with classic cranial GCA. Upper extremity vascular insufficiency dominated the clinical presentation of patients with large-vessel GCA, whereas symptoms related to impaired cranial blood flow were infrequent. Temporal artery biopsy findings were negative in 42% of patients with large-vessel GCA. Polymyalgia rheumatica occurred with similar frequency in both patient groups. Large-vessel GCA was associated with higher concentrations of interleukin-2 gene transcripts in arterial tissue and overrepresentation of the HLA-DRB1*0404 allele, indicating differences in pathogenetic mechanisms. CONCLUSION: GCA is not a single entity but includes several variants of disease. Large-vessel GCA produces a distinct spectrum of clinical manifestations and often occurs without involvement of the cranial arteries. Large-vessel GCA requires a different approach to the diagnosis and probably also to treatment.  (+info)

Ovine MHC class II DRB1 alleles associated with resistance or susceptibility to development of bovine leukemia virus-induced ovine lymphoma. (5/3769)

For the further characterization of bovine leukemia virus (BLV)-induced leukemogenesis, we investigated the association between polymorphism of ovine leukocyte antigen (OLA)-DRB1 gene and tumor development after infection of sheep with BLV. We infected 28 sheep with BLV and cloned exon 2 of the OLA-DRB1 gene from asymptomatic animals and from animals with lymphoma Sequence analysis revealed that, among 12 healthy sheep without any evidence of tumor, ten (83.3%) carried DRB1 alleles encoding Arg-Lys (RK) at positions beta70/71 as compared with only 6 (37.5%) of the 16 sheep with lymphoma, which suggested that alleles encoding the RK motif might protect against development of tumors after infection by BLV. By contrast, alleles encoding Ser-Arg (SR) at positions beta70/71 were present at a significantly elevated frequency in sheep with lymphoma as compared with the healthy carriers, which indicated that OLA-DRB1 alleles encoding the SR motif might be positively related to susceptibility to tumor development. The two amino acids in these motifs line a pocket that accommodates the side chain of a bound peptide according to a model of the crystal structure of human leukocyte antigen (HLA)-DR1. To analyze immunoreactions of sheep with alleles that encoded RK or SR at beta70/71, we selected sheep with either the RK/SR genotypes or the SR/SR genotypes and immunized them with a mixture of multiple synthetic antigenic peptides that corresponded to T-helper, T-cytotoxic, and B-cell epitopes of the BLV envelope glycoprotein gp51. Two weeks after the last immunization, all of the sheep were challenged with BLV. Sheep with the RK/SR genotype produced neutralizing antibodies against BLV; they eliminated BLV completely within 28 weeks of the BLV challenge, and they gave strong lymphocyte-proliferative responses to the peptides used for immunization. Moreover, such animals did not develop lymphoma. By contrast, sheep with the SR/SR genotype continued to produce BLV throughout the experimental period and developed terminal disease. Our results indicate that the differences in immunoresponse were due to differences in major histocompatibility complex class II alleles and reflected the risk of BLV-induced leukemogenesis. In addition, it appears that susceptibility to tumor development may be determined to some extent by polymorphic residues binding to antigenic peptides directly within the binding cleft of the OLA-DR molecule.  (+info)

Bone marrow and peripheral blood dendritic cells from patients with multiple myeloma are phenotypically and functionally normal despite the detection of Kaposi's sarcoma herpesvirus gene sequences. (6/3769)

Multiple myeloma (MM) cells express idiotypic proteins and other tumor-associated antigens which make them ideal targets for novel immunotherapeutic approaches. However, recent reports show the presence of Kaposi's sarcoma herpesvirus (KSHV) gene sequences in bone marrow dendritic cells (BMDCs) in MM, raising concerns regarding their antigen-presenting cell (APC) function. In the present study, we sought to identify the ideal source of DCs from MM patients for use in vaccination approaches. We compared the relative frequency, phenotype, and function of BMDCs or peripheral blood dendritic cells (PBDCs) from MM patients versus normal donors. DCs were derived by culture of mononuclear cells in the presence of granulocyte-macrophage colony-stimulating factor and interleukin-4. The yield as well as the pattern and intensity of Ag (HLA-DR, CD40, CD54, CD80, and CD86) expression were equivalent on DCs from BM or PB of MM patients versus normal donors. Comparison of PBDCs versus BMDCs showed higher surface expression of HLA-DR (P =.01), CD86 (P =. 0003), and CD14 (P =.04) on PBDCs. APC function, assessed using an allogeneic mixed lymphocyte reaction (MLR), demonstrated equivalent T-cell proliferation triggered by MM versus normal DCs. Moreover, no differences in APC function were noted in BMDCs compared with PBDCs. Polymerase chain reaction (PCR) analysis of genomic DNA from both MM patient and normal donor DCs for the 233-bp KSHV gene sequence (KS330233) was negative, but nested PCR to yield a final product of 186 bp internal to KS330233 was positive in 16 of 18 (88.8%) MM BMDCs, 3 of 8 (37.5%) normal BMDCs, 1 of 5 (20%) MM PBDCs, and 2 of 6 (33.3%) normal donor PBDCs. Sequencing of 4 MM patient PCR products showed 96% to 98% homology to the published KSHV gene sequence, with patient specific mutations ruling out PCR artifacts or contamination. In addition, KHSV-specific viral cyclin D (open reading frame [ORF] 72) was amplified in 2 of 5 MM BMDCs, with sequencing of the ORF 72 amplicon revealing 91% and 92% homology to the KSHV viral cyclin D sequence. These sequences again demonstrated patient specific mutations, ruling out contamination. Therefore, our studies show that PB appears to be the preferred source of DCs for use in vaccination strategies due to the ready accessibility and phenotypic profile of PBDCs, as well as the comparable APC function and lower detection rate of KSHV gene sequences compared with BMDCs. Whether active KSHV infection is present and important in the pathophysiology of MM remains unclear; however, our study shows that MMDCs remain functional despite the detection of KSHV gene sequences.  (+info)

Identification of MAGE-3 epitopes presented by HLA-DR molecules to CD4(+) T lymphocytes. (7/3769)

MAGE-type genes are expressed by many tumors of different histological types and not by normal cells, except for male germline cells, which do not express major histocompatibility complex (MHC) molecules. Therefore, the antigens encoded by MAGE-type genes are strictly tumor specific and common to many tumors. We describe here the identification of the first MAGE-encoded epitopes presented by histocompatibility leukocyte antigen (HLA) class II molecules to CD4(+) T lymphocytes. Monocyte-derived dendritic cells were loaded with a MAGE-3 recombinant protein and used to stimulate autologous CD4(+) T cells. We isolated CD4(+) T cell clones that recognized two different MAGE-3 epitopes, MAGE-3114-127 and MAGE-3121-134, both presented by the HLA-DR13 molecule, which is expressed in 20% of Caucasians. The second epitope is also encoded by MAGE-1, -2, and -6. Our procedure should be applicable to other proteins for the identification of new tumor-specific antigens presented by HLA class II molecules. The knowledge of such antigens will be useful for evaluation of the immune response of cancer patients immunized with proteins or with recombinant viruses carrying entire genes coding for tumor antigens. The use of antigenic peptides presented by class II in addition to peptides presented by class I may also improve the efficacy of therapeutic antitumor vaccination.  (+info)

Melanoma cells present a MAGE-3 epitope to CD4(+) cytotoxic T cells in association with histocompatibility leukocyte antigen DR11. (8/3769)

In this study we used TEPITOPE, a new epitope prediction software, to identify sequence segments on the MAGE-3 protein with promiscuous binding to histocompatibility leukocyte antigen (HLA)-DR molecules. Synthetic peptides corresponding to the identified sequences were synthesized and used to propagate CD4(+) T cells from the blood of a healthy donor. CD4(+) T cells strongly recognized MAGE-3281-295 and, to a lesser extent, MAGE-3141-155 and MAGE-3146-160. Moreover, CD4(+) T cells proliferated in the presence of recombinant MAGE-3 after processing and presentation by autologous antigen presenting cells, demonstrating that the MAGE-3 epitopes recognized are naturally processed. CD4(+) T cells, mostly of the T helper 1 type, showed specific lytic activity against HLA-DR11/MAGE-3-positive melanoma cells. Cold target inhibition experiments demonstrated indeed that the CD4(+) T cells recognized MAGE-3281-295 in association with HLA-DR11 on melanoma cells. This is the first evidence that a tumor-specific shared antigen forms CD4(+) T cell epitopes. Furthermore, we validated the use of algorithms for the prediction of promiscuous CD4(+) T cell epitopes, thus opening the possibility of wide application to other tumor-associated antigens. These results have direct implications for cancer immunotherapy in the design of peptide-based vaccines with tumor-specific CD4(+) T cell epitopes.  (+info)

HUMAN LEUKOCYTE ANTIGEN DR ALLELE 1 DONOR is the ORGAN OR TISSUE DONORs Human Leukocyte Antigen DR Allele 1, as contained in the Human Leukocyte Antigen report for Tissue Typing ...
Mortality from ruptured abdominal aortic aneurysms (RAAA) remains high. Severe systemic inflammation, leading to multi-organ failure, often occurs in these patients. In this study we describe the level of HLA-DR expression in a consecutive group of patients following surgery for RAAA and compare results between survivors and non-survivors. A similar comparison is made for IL-6 and IL-10 levels and Sequential Organ Failure Assessment (SOFA) scores. This is a prospective observational study. Patients with RAAA were prospectively analysed. Blood samples were collected on days 1, 3, 5, 7, 10 and 14. The fraction of CD-14 positive monocytes expressing HLA-DR was measured by flow-cytometry. IL-6 and IL-10 levels were measured by ELISA. The study included 30 patients with a median age of 70 years, of which 27 (90%) were men. Six patients died from multiple organ failure, all other patients survived. The SOFA scores were significantly higher in non-survivors on days 1 through 14. HLA-DR expression on monocytes
In normal human epidermis, expression of HLA-DR antigen is restricted to Langerhans cells (LC) and acrosyringial epithelium. However, in diseases such as lichen planus and graft-vs.-host, HLA-DR antigen appears to be expressed by keratinocytes, although the exact source of the HLA-DR is unclear. Two possibilities are that (1) the HLA-DR is shed by neighboring immunocompetent cells, or (2) that the keratinocytes are synthesizing the antigen themselves. Recently, gamma interferon has been shown to induce HLA-DR biosynthesis and expression on human malignant melanoma cells lines and on normal vascular endothelium. We report here that pure recombinant human gamma interferon (100 units/ml) induces HLA-DR expression on 60-70% of cultured human adult keratinocytes depleted of LC within 2-4 days of culture as determined by fluorescence-activated cell sorter (FACS) analysis using monoclonal antibodies. No residual LC or lymphocytes could be detected in these cultures. This is the first demonstration of HLA-DR
Monocyte HLA-DR expression has been reported as a marker of immunosuppression and a predictor of sepsis development. However, to date, there is no report on monocyte HLA-DR monitoring exclusively in neonates (| 28 days of life) who underwent cardiac surgery under cardiopulmonary bypass (CPB), which have a high risk of nosocomial infection. In this pilot study, we studied nine neonates with a diagnosis of congenital heart disease requiring surgery under CPB. There was a significant reduction in monocyte HLA-DR expression for the first two postoperative days, as compared to preoperatively (p = 0.004). Moreover, neonates who displayed an episode of NI had a dramatically lower HLA-DR expression at day 4, as compared to neonates without NI (4257 AB/c [2220-5895] vs 14,947 AB/c [9858-16,960]; p = 0.04). Our preliminary results could indicate that HLA-DR expression may be a useful biomarker of immunosuppression-induced secondary infection after CPB in neonates.
HLA-DR antigen expression in colorectal carcinomas: influence of expression by IFN-gamma in situ and its association with tumour progression.: The authors attem
The findings we have described here show a clear association between epithelial HLA-D/DR expression and autoimmunity. Furthermore, the ability of class II+ thyrocytes to present both exogenous antigens and autoantigens indicates an active role for these HLA-D/DR molecules in autoimmune pathogenesis. IFN-gamma is capable of inducing HLA-D/DR expression by thyroid epithelium, but a number of observations suggest the involvement of other inducers as well. Overall, we conclude that epithelial class II expression very probably plays a key role in the propagation and also in possibly the initiation of autoimmune attack. This is in accord with the proposal of a more general relationship between inappropriate or excessive class II expression and pathogenesis.
HLA-DR3- and HLA-DRw52-associated functional polymorphism was investigated with selected tetanus toxoid (TT)-specific T cell clones. We have shown earlier that HLA-DR antigens are encoded by two distinct loci, DR beta I and DR beta III. The alloantigenic determinant(s) defined by the serological HLA-DR3 specificity map to the former, while the supratypic HLA-DRw52 determinants map to DR beta III. Furthermore, we have recently recognized by DNA sequencing three alleles of HLA-DRw52 at locus DR beta III, referred to as 52 a, b, and c. Our objective was to correlate the pattern of T cell restriction with the gene products of individual DR beta chain loci and with the three newly described alleles of locus DR beta III. Among the selected T cell clones, 5 reacted exclusively when TT was presented by HLA-DR3+ APCs (TT-DR3-APC). In contrast, two T cell clones were stimulated by TT-DRw52-APC. More specifically, these two T cell clones (Clones 10 and 16) were stimulated by different subsets of ...
HLA Class II DR, 0.1 mg. |p|HLA DR antigen is an HLA class II antigen with homology to murine H-2E. HLA-DR is an αβ heterodimer.
Anti-HLA-DR antibodies react with the human major histocompatibility (MHC) class II antigen HLA-DR. HLA-DR is constitutively expressed on professional antigen-presenting cells like dendritic cells, B cells, and monocytes/macrophages. Its expression is further up-regulated upon activation. On T cells, NK cells, hematopoietic precursor cells, and some epithelial cells the expression of HLA-DR is induced by cell activation. | Principat dAndorra
Eluted natural peptides from major histocompatibility molecules show patterns of conserved residues. Crystallographic structures show that the bound peptide in class II major histocompatibility complex adopts a near uniform polyproline II-like conformation. This way allele-specific favoured residues are able to anchor into pockets in the binding groove leaving other peptide side chains exposed for recognition by T cells. The anchor residues form a motif. This sequence pattern can be used to screen large sequences for potential epitopes. Quantitative matrices extend the motif idea to include the contribution of non-anchor peptide residues. This report examines two new matrices that extend the binding register to incorporate the polymorphic p10 pocket of human leukocyte antigen DR1. Their performance is quantified against experimental binding measurements and against the canonical nine-residue register matrix. One new matrix shows significant improvement over the base matrix; the other does not. The new
A human CD4 clone (Mx9/9) using the V beta 8 receptor was used as antigen to generate autologous clones (termed anti-Mx9/9 clones) which proliferate in response to this clone, but not other autologous clones. This was used as an experimental model to explore the specific interactions between autologous T cells. Anti-HLA-DR monoclonal antibodies inhibited the response of the anti-Mx9/9 clones, suggesting that these clones recognize their target antigen in association with HLA-DR. Because of the specificity of the anti-Mx9/9 clones for the initiating clone (Mx9/9), but not any other autologous V beta 8- or V beta 8+ CD4 clones, the target antigen seems to be part of the T cell receptor, but not V beta 8 itself. However, the anti-Mx9/9 clones responded also to the autologous EBV line, and thus the target antigen is not known. The regulatory activity of the anti-Mx9/9 clones was assayed by coculture with their target clone. A variety of responses were seen, both inhibitory and stimulatory, which varied
Human plasmacytoid dendritic cells secrete high levels of IFNa and are thus implicated in the activation of NK cells. Activated NK cells are characterised by the up-regulation of CD69 and MHC class II DR expression, secretion of IFN g and enhanced cytotoxicity. We show that pDC mediate these processes by different mechanisms, some of which overlap. Human NK cells were analysed after co-culture with immature or CpG-matured blood pDC or with supernatant from these cells. Maximal CD69 expression by NK cells was mediated by supernatant from mature pDC and did not require pDC contact. Up-regulation was due in part to IFNa but also to factors in IFNa negative supernatant from immature DC. HLA-DR expression was independent of secreted molecules but required contact with immature or mature DC. Enhanced NK cytotoxicity, measured by killing of K562 targets and expression of CD107a, was mediated by multiple factors including type I IFN, supernatant from immature pDC cultures and contact with immature or mature pDC
Downregulation of Blood Monocyte HLA-DR in ICU Patients Is Also Present in Bone Marrow Cells. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
Encoded by multiple HLA-DRA and HLA-DRB genes in a complex variable 5 cM region of MHC between HLA-B and -D, HLA-DR Antigens are Class II histocompatibility transmembrane glycoprotein heterodimers of alpha (heavy, 35-kD) and beta (light, 27-kD) chains. Located predominantly on B cells and macrophages, HLA-DR antigens function in antigen presentation to regulatory T cells in the immune response and in self/nonself discrimination. Invariant alpha and polymorphic beta chains have glycosylated N-termini, hydrophobic membrane regions, and hydrophilic C-termini. The heterodimer consists of 4 extracellular domains; invariant alpha-1, polymorphic N-terminal beta-1, and conserved Ig-like alpha-2 and beta-2. Alpha-1 and alpha-2 contain disulfide loops. Beta-1 contains 2 small variable regions. Alpha sequences have relatively simple structure; beta chains carry the major polymorphic determinants ...
MHC Class II DR, 0.25 mg. The distribution of ovine DR molecules on T lymphocytes has been shown to vary with immune status and age.
HLA-DR beta antibody [TDR 31.1] for ELISA, FACS, RIA. Anti-HLA-DR beta mAb (GTX40182) is tested in Human samples. 100% Ab-Assurance.
Blast cells from peripheral blood of 32 patients with acute leukemia were tested for their ability to react with a monoclonal antibody (D1.B6) specific for HLA-DR surface antigen. In order to evaluate the degree of leukemic cell differentiation a monoclonal antibody (R1.B19) specific for the granulocytopoietic lineage was also employed. The results demonstrated that a considerable proportion of blast cell populations expressed the HLA-DR antigen, while only a small fraction of cells expressed the myeloid antigen.
ALPS panel uses antibodies against CD3, CD4, CD8, CD45, alpha beta TCR, CD25, CD27, HLA-DR, CD19, CD5, CD27, and B220 to create a panel that quantifies double negative T cells, CD27+ B cells, and CD25 and HLA-DR expression on T cells to rank the likelihood of ALPS. Test Code: ALPS Panel by Flow. ...
Mouse monoclonal Ovine MHC Class II DR antibody [37.68] validated for IP, IHC, Flow Cyt and tested in Human, Shp, Goat and Cow. Immunogen corresponding to…
Correlation study on CD7, CD34, CD56 and HLA-DR expressions and its prognosis among patients with acute myeloid leukemia, Shishan Xiao, Hongqian Zhu
Postoperative, an adequate response of the immune system depends on a balanced interplay between lymphocytes of T-helper type Th1 and Th2, an intact interaction between macrophages / monocytes and T-lymphocytes as well as an adequate balance of cytokines. Surgery interferes with the complex balance of immune system with the consequence of an altered immune response. Cardiac surgery with cardiopulmonary bypass is associated with an exaggerated and imbalanced release of cytokines and an altered immune response. A SIRS may occure. Also, cell related immune function may be suppressed. Particiularly monocyte functions can be affected, as HLA-DR expression and lipopolysaccharide stimulated ex vivo TNF-α secretion. The influence of the opioides fentanyl and remifentanil on HLA-DR expression and ex vivo TNF-α secretion has not been investigated (primary aim of the study). Further, the postoperative course had to be evaluated (secondary aim of the study). 37 patients undergoing elective CABG surgery ...
Cell lines. Colon cancer cell line HT29, rectal cancer cell lines SW837 and SW1463, and Ramos B-cell line were all cultured in Iscoves modified Dulbeccos medium (Cambrex) supplemented with glutamine, penicillin/streptomycin, and 8% heat-inactivated FCS, at 37°C. Where indicated, exponentially growing cells were treated with 100 units/mL human recombinant IFNγ for the indicated time periods.. Visualization of HLA-DR on surface of cell lines. For these experiments, IFNγ-treated or untreated growing cells were harvested, washed, and resuspended in PBS supplemented with 0.5% bovine serum albumin and 0.05% sodium azide (PBA). Cells were incubated with a monoclonal FITC-labeled anti-HLA-DR antibody at 1:50 (BD Biosciences) for 30 min at 4°C. PBA alone was used as negative control. Antibody binding was detected with the use of a FACSCalibur (BD Biosciences). Propidium iodide was added to allow exclusion of dead cells.. Promoter-specific reverse transcription-PCR for class II transactivator. ...
p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.,/p> ,p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.,/p> ,p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).,/p> ,p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x,sup>64,/sup> + x,sup>4,/sup> + x,sup>3,/sup> + x + 1. The algorithm is described in the ISO 3309 standard. ,/p> ,p class=publication>Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.,br /> ,strong>Cyclic redundancy and other checksums,/strong>,br /> ,a href=http://www.nrbook.com/b/bookcpdf.php>Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993),/a>),/p> Checksum:i ...
Im not an RNA guy, but your sequence-specific primer approach sounds OK to me. I would design primers that cross an exon-exon boundry so as not to amplify contaminating genomic DNA, and recall that the Tm of DNA-RNA hybrids is different from the Tm of DNA-DNA hybrids (see the reference note here).. ...
HLA-DR, APC, clone: LN3, eBioscience™ 100 Tests; APC HLA-DR, APC, clone: LN3, eBioscience™ Primary Antibodies Hj to Hr
HLA-DR, eVolve 605, clone: LN3, eBioscience™ 100 Tests; eVolve 605 HLA-DR, eVolve 605, clone: LN3, eBioscience™ Primary Antibodies Hj to Hr
ウサギ・ポリクローナル抗体 ab118347 交差種: Hu 適用: WB,IP…HLA-DR抗体一覧…画像、プロトコール、文献などWeb上の情報が満載のアブカムの Antibody 製品。国内在庫と品質保証制度も充実。
To compare the changes in cellular markers of IA (changes in the proportion ofCD4+ or CD8+ T cells that express HLA-DR and/or CD38) during the rifaximin phase of the study and compare it with the changes in cellular markers of activation during ...
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Recent randomized trials have not found that polymyxin B hemoperfusion (PMX-HP) improves outcomes for patients with sepsis. However, it remains unclear whether the therapy could provide benefit for highly selected patients. Monocyte human leukocyte antigen (mHLA-DR) expression, a critical step in the immune response, is decreased during sepsis and leads to worsening sepsis outcomes. One recent study found that PMX-HP increased mHLA-DR expression while another found that the treatment removed HLA-DR-positive cells. We conducted a randomized controlled trial in patients with blood endotoxin activity assay (EAA) level ≥ 0.6. Patients in the PMX-HP group received a 2-h PMX-HP treatment plus standard treatment for 2 consecutive days. Patients in the non-PMX-HP group received only standard treatment. The primary outcome compared the groups on median change in mHLA-DR expression between day 3 and baseline. Secondary outcomes compared the groups on the mean or median change in CD11b expression, neutrophil
Author(s): Donaldson PT. Publication type: Editorial. Publication status: Published. Journal: Hepatology. Year: 2011. Volume: 53. Issue: 6. Pages: 1798-1800. Print publication date: 25/05/2011. ISSN (print): 0270-9139. ISSN (electronic): 1527-3350. Publisher: John Wiley & Sons, Inc. URL: http://dx.doi.org/10.1002/hep.24389. DOI: 10.1002/hep.24389. ...
T-cell and B-cell responses to genetic immunization differ in DR3 and DR2 transgenic mice, and there is less genetic control of antibody than of T-cell responses. During both genomic and peptide epitope immunization there was evidence of epitope spreading during the immunization. Several functionall …
Predicting patient outcome for colorectal carcinoma (CRC) with lymph node but not distant metastases remains challenging. Various prognostic markers have been identified including microsatellite instability (MSI) and possibly expression of the MHC Class II protein, HLA-DR. About 15% of sporadic CRC exhibits MSI associated with methylation of the DNA mismatch repair gene hMLH1 promoter. In addition, a significant proportion of unselected CRC demonstrates expression of HLA-DR. We sought to examine the relationship between HLA-DR expression, MSI status and prognosis in sporadic Australian Clinicopathological (ACP) Stage C CRC. Two hundred seventy consecutive patients with sporadic ACP Stage C CRC were treated at Concord Repatriation General Hospital between 1986 and 1992. None of these patients received adjuvant chemotherapy and all were followed for a minimum of 5 years or until death. DNA was extracted from paraffin sections and MSI status determined by PCR. HLA-DR expression was determined ...
Reactome is pathway database which provides intuitive bioinformatics tools for the visualisation, interpretation and analysis of pathway knowledge.
Background: Pediatric bronchial asthma is associated with considerable morbidity. The study was carried out to examine the association of Human Leukocyte Antigen (HLA)- Class II with the disease as we found no similar study on Asian Indian population. Objective: To define the HLA-Class II antigens in Asian Indian pediatric patients with asthma. Methods: A total of 103 children with asthma and 152 controls were analysed for HLA Class II (DRB1, DQB1and DPB1) by PCR-SSP (Sequence Specific Primers) method. Total serum IgE levels were determined by ELISA assay. Results: A positive family history was recorded in 59 patients (57%) and 13 (8.5%) of healthy controls. Serum IgE levels were more than normal range in 72% of the patients and 33% of healthy subjects with mean values of 4877 and 627 IU/ml, respectively. DRB1*04 and DQB1*03 showed significant positive relations while DRB1*15 showed a negative association with asthma. DQB1*02 was more common in healthy individuals but was not statistically significant.
HLA-DR3 is composed of the HLA-DR17 and HLA-DR18 split antigens serotypes. DR3 is a component gene-allele of the AH8.1 haplotype in Northern and Western Europeans. Genes between B8 and DR3 on this haplotype are frequently associated with autoimmune disease. Type 1 diabetes mellitus is strongly associated with HLA-DR3 or HLA-DR4. Some DR3 also react with HLA-DR17 and/or HLA-DR18. The DRB1*0304 primarily reacts with DR3. The serotypes of *0305, *0306, *0308 to *0331 are unknown. HLA-DR3 is associated with early-age onset myasthenia gravis, Hashimotos thyroiditis (along with DR5), primary sclerosing cholangitis, and opportunistic infections in AIDS, but lowered risk for cancers. It is also associated with Membranous glomerularnephritis DRB1*0301 (see HLA-DR17) DRB1*0302 (See HLA-DR18) DRB1*0304 is associated with graves disease DR3 and/or DQ2 is associated with Moreens ulceration, bout onset multiple sclerosis, Graves disease and systemic lupus erythematosus DR3-DQ2 linkage is associated ...
HLA-DR is an MHC class II cell surface receptor encoded by the human leukocyte antigen complex on chromosome 6 region 6p21.31. The complex of HLA-DR (Human Leukocyte Antigen - antigen D Related) and its ligand, a peptide of 9 amino acids in length or longer, constitutes a ligand for the T-cell receptor (TCR). HLA (human leukocyte antigens) were originally defined as cell surface antigens that mediate graft-versus-host disease. Identification of these antigens has led to greater success and longevity in organ transplant. Antigens most responsible for graft loss are HLA-DR (first six months), HLA-B (first two years), and HLA-A (long-term survival). Good matching of these antigens between host and donor are most critical for achieving graft survival. HLA-DR is also involved in several autoimmune conditions, disease susceptibility and disease resistance. It is also closely linked to HLA-DQ and this linkage often makes it difficult to resolve the more causative factor in disease. HLA-DR molecules are ...
The T cell response to a mixture of eight peptides derived from sequences of the Mycobacterium tuberculosis 16-, 19- and 38-kD antigens (MTBmix-8) has been studied. The peptides were selected on the basis of complementary binding to nine HLA-DR molecules (HLA-DR1 to DR9). MTBmix-8 at 6.25 and 50 mic …
FGF-2 and, to a lesser extent, PDGF-BB induced in adult human MSCs the expression of HLA-DR (normally induced by inflammatory cytokines), which was able to stimulate CD4+ T cells via superantigen binding. In contrast to IFNγ, FGF induced HLA-DR expression only in human MSCs proliferating under its mitogenic effect and not in mouse MSCs or in differentiated human cells. Although it induced cell proliferation, human platelet lysate did not cause HLA-DR expression in human MSCs. HLA-DR expression occurred following FGF-specific binding to its receptor(s), mainly FGF receptor 1, without inducing IFNγ or tumor necrosis factor α expression. Both MAPK/ERK-1/2 and phosphatidylinositol 3-kinase/Akt controlled cell proliferation and HLA-DR expression, but only MAPK/ERK-1/2 controlled the induction of the class II MHC transcription activator protein CIITA, the major determinant of HLA-DR transcription. ...
The PDB archive contains information about experimentally-determined structures of proteins, nucleic acids, and complex assemblies. As a member of the wwPDB, the RCSB PDB curates and annotates PDB data according to agreed upon standards. The RCSB PDB also provides a variety of tools and resources. Users can perform simple and advanced searches based on annotations relating to sequence, structure and function. These molecules are visualized, downloaded, and analyzed by users who range from students to specialized scientists.
The PDB archive contains information about experimentally-determined structures of proteins, nucleic acids, and complex assemblies. As a member of the wwPDB, the RCSB PDB curates and annotates PDB data according to agreed upon standards. The RCSB PDB also provides a variety of tools and resources. Users can perform simple and advanced searches based on annotations relating to sequence, structure and function. These molecules are visualized, downloaded, and analyzed by users who range from students to specialized scientists.
The Human Immunology Portal has links to a wide array of tools and databases (http://www.humanimmunologyportal.com/hiptools/). 1. MHC epitopes data bases and epitope prediction software http://www.iedb.org/ The IEDB hosts tools to assist in the prediction and analysis of B cell and T cell epitopes (has exhaustive list of tools). For a list of T cell epitopes in cancer, see also http://cancerimmunity.org/peptide/. http://www.cbs.dtu.dk/services/NetMHCIIpan/: NetMHCIIpan 3.0 server predicts binding of peptides to MHC class II molecules. http://www.cbs.dtu.dk/services/NetMHCII/ NetMHCII 2.2 server predicts binding of peptides to HLA-DR, HLA-DQ, HLA-DP and mouse MHC class II alleles using articial neuron networks.. Predictions can be obtained for 14 HLA-DR alleles covering the 9 HLA-DR supertypes, six HLA-DQ, six HLA-DP, and two mouse H2 class II alleles.. Class I predictions. ANNs have been trained for 78 different Human MHC (HLA) alleles representing all 12 HLA A and B Supertypes. Furthermore 41 ...
Di dalam kajian ini, Human Leukocyte Antigen (HLA) kelas I dan II telah dianalisa dengan menggunakan kaedah pencetus penjujukan khusus (Sequence Specific Primer) di kalangan 176 individu yang tiada pertalian kekeluargaan dari 6 kumpulan sub-etnik Melayu di Semenanjung Malaysia: In this study, the Human Leukocyte Antigen (HLA) class I and II were examined through Sequence Specific Primer (SSP) typing in 176 unrelated individuals from 6 Malay sub-ethnic groups of Peninsular Malaysia:. ...
Mouse Monoclonal Anti-HLA-DR Antibody (L243) cited in 28 publications. Validated: WB, ELISA, EM, Flow, Flow-CS, Func, ICC/IF, IHC, IHC-Fr, IHC-P, In vitro, IP, B/N, CyTOF-ready, Dual ISH-IHC. Tested Reactivity: Human, Canine, Baboon, and more.
Transmembrane Proteins that form the alpha subunits of the HLA-DR Antigens. They are also referred to as the HLA-DR heavy chains ...
Vaccination of colon cancer patients with X-irradiated autologous tumor cells and Bacillus Calmette-Guérin results in a significant reduction in tumor recurrence. A study was undertaken to determine whether the expression of tumor-associated antigens, expression of major histocompatibility complex molecules, or the cellular composition of the vaccine cells correlates with vaccine efficacy. A significant increase in the percentage of histocompatibility leukocyte antigen (HLA) class II molecule-expressing tumor cells was the only marker with a positive correlation. Because HLA class II molecule expression is not a prognostic marker in control patients, it was hypothesized that HLA class II molecules are involved in the induction of tumor immunity in patients treated with the autologous colon tumor vaccine. Enhancement of HLA class II molecule-expressing cells could be induced in X-irradiated colon tumor cells injected into the skin of mice when the cells were mixed with γ-interferon. Therefore, ...
Cellular immunity plays an important role in the control of persistent virus infections such as hepatitis C virus (HCV). Antiviral CD4(+) T cell responses have been shown to accompany resolution of acute disease and there is also a consistent association between HLA Class II genes, notably HLADRB1*1101 (and the closely linked HLADQB1*0301) and disease resolution. We initially mapped longitudinal CD4(+) T cell responses in an individual after spontaneous resolution of acute HCV, and identified three HLA-DR11-restricted responses which vary in immunodominance over time. Functional assays and HLA Class II tetramer staining revealed one to be a response to a commonly recognized epitope, NS3(1248-1261), although cytokine capture assays showed these specific cells to be at a very low frequency. In this patient, and in others reported, this most frequently recognized HLA-DR11 restricted epitope is not immunodominant. We analysed whether sequence variability within and between genotypes might account for
NetMHCII 2.0 server predicts binding of peptides to HLA-DR and mouse MHC class II alleles using articial neuron networks. Predictions can be obtained for 14 HLA-DR alleles covering the 9 HLA-DR supertypes, and three mouse H2 class II alleles. The predictions are given in nM IC50 values and as a %-Rank to a set of 1000.000 random natural peptides. Strong and weak binding peptides are indicated in the output. The server can be run in two modes. Default mode is without P1 amino acids preference. This mode is recommended for accurate binding affinity prediction. The other mode includes P1 amino acids preference encoding, and is turned on selecting the Turn of P1 amino acid preference option. This option is recommended for accurate binding core identification ...
HLA-DR is a αβ heterodimer cell surface receptor in the HLA system. The subunits are coded by the genes: HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5. DRA is functionally preserved, and the variation comes from the 4 β-chain loci. There are only 2 distinct α peptides, but 100s of B1 variants and 10s from B3-B5. The combinations determine the DR serotype: DR1-DR18, and DR51-53 from DRB3-DRB5. DR type is associated with many autoimmune conditions and other diseases. ...
Mouse monoclonal antibody raised against native human HLA-DR. Mononuclear cell leukemia acute undifferentiated. (MAB15424) - Products - Abnova
Mouse monoclonal antibody raised against native human HLA-DR. Mononuclear cell leukemia acute undifferentiated. (MAB15428) - Products - Abnova
4586 A number of studies have shown that HLA-DR, DQ and DP alleles are associated with an increased risk of paediatric acute lymphoblastic leukaemia (ALL), but the significance of these multiple HLA locus/allele associations for the aetiology of childhood ALL remains uncertain. One possibility is that they denote differences in immune responsiveness to a causative infection(s), mediated by the differential antigenic peptide-binding efficiency of HLA class II alleles. We previously reported that B cell precursor ALL [BCP] was associated with HLA-DPB1*0201 and related alleles with glutamic acid (E) at position DPβ169 in the P4 peptide binding pocket (PBP). However, recent studies suggest that DPB1 alleles can be clustered into a small number of functional supertypes based on the shared peptide binding characteristics of several PBP. To determine whether these influence the risk of BCP ALL, we clustered DPB1 alleles into 3 pairs of supertypes, defined by di-allelic polymorphisms at DPβ184, 69 and ...
Loh, M.T.,Chan, S.H.,Ren, E.C. (1993). A monoclonal antibody with specificity to the HLA-DR1 and -DR51 antigens. Tissue Antigens 42 (2) : 100-104. [email protected] Repository ...
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Hello,. I am a student doing research in a laboratory. We have collected flow cytometry data but would now like to identify the number of monocytes labeled with HLA-DR using Bioconductor in R. How would I go about doing that?. ...
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Please state whether you are in agreeance or disagreeance w/ my answer to the DQ1 question and why? DQ question: 1. What - Answered by a verified Tutor
Low levels of human leukocyte antigen (HLA-DR) make MSC's hypoimmunogenic. MSC's have trilineage differentiation where they are ...
Macrophages and T lymphocytes demonstrated a marked expression of HLA-DR antigen. A delayed type hypersensitivity reaction of ...
Human leukocyte antigen (HLA)-DR is positive in most patients. Occasional cases require in situ hybridization to identify the ... but immunophenotyping demonstrates myeloid antigens. In acute myeloblastic leukemia (M0), the blasts are agranular and ...
Macrophages and lymphocytes show marked expression of HLA-DR antigen. Arguably XO is the bone localization of the ...
Peptide and Peptide Mimetic Inhibitors of Antigen Presentation by HLA-DR Class II MHC Molecules. Design, Structure−Activity ...
HLA class II histocompatibility antigen gamma chain also known as HLA-DR antigens-associated invariant chain or CD74 (Cluster ... Riberdy JM, Newcomb JR, Surman MJ, Barbosa JA, Cresswell P (December 1992). "HLA-DR molecules from an antigen-processing mutant ... "Membrane insertion and oligomeric assembly of HLA-DR histocompatibility antigens" (PDF). Cell. 29 (1): 61-9. doi:10.1016/0092- ... "Biosynthesis and glycosylation of the invariant chain associated with HLA-DR antigens". Journal of Immunology. 129 (6): 2564-9 ...
CD74 (англ. HLA class II histocompatibility antigen gamma chain; HLA-DR antigens-associated invariant chain) - мембранный белок ... HLA-DR gamma chainCD74HLA class II histocompatibility antigen gamma chaingamma chain of class II antigensIiHLA-DR antigens- ... Riberdy J.M., Newcomb J.R., Surman M.J., Barbosa J.A., Cresswell P. HLA-DR molecules from an antigen-processing mutant cell ... Machamer C.E., Cresswell P. Biosynthesis and glycosylation of the invariant chain associated with HLA-DR antigens (англ.) // ...
... class II Human Leucocyte Antigens (HLA) DR-11. Dr Okello joined the Uganda Heart Centre in 2010. In an interview that he gave ... MESAU Consortium Uganda (2015). "Dr. Emmy Okello PhD Defence: Burden, Risk Factors And Outcome of Rheumatic Heart Disease in ... Africa Stemi (2019). "Africa Stemi Live 2019: 25th to 27th April 2019: Radisson Blue Hotel Nairobi: Speakers: Dr Emmy Okello, ... Thrive Organization Uganda (2017). "Dr Emmy Okello". Kampala: Thrive.or.ug. Retrieved 8 April 2019. Emmy Okello (2019). "Emmy ...
RFD7 and HLA-DR antigens, it was found that all epithelioid cells have an immunological phenotype RFD9+/RFD7-/HLA-DR+. A series ...
... a conserved transcriptional element in the promoter of the human leukocyte antigen (HLA) DR alpha. The expression of this ... Liou HC, Eddy R, Shows T, Lisowska-Grospierre B, Griscelli C, Doyle C, Mannhalter J, Eibl M, Glimcher LH (1991). "An HLA-DR ... "A new member of the leucine zipper class of proteins that binds to the HLA DR alpha promoter". Science. 247 (4950): 1581-4. doi ...
... function and tissue distribution of HLA-DR and Ia antigens. From 1990 to 1993, he held the chair of clinical immunology at ... The presence of HLA-DR shared epitope (SE) genes was a risk factor for RA with the presence of anticitrulline antibodies but ... For smokers there was a large interaction between smoking and HLA-DR SE genes for anticitrulline-positive RA but not for ... 36-45 doi:10.1002/art.23188 A new model for rheumatoid arthritis: Smoking may trigger HLA-DR (shared epitope) -restricted ...
T6 Antigens) and Class II Molecules (HLA-DR Antigens) » Proceedings of the National Academy of Sciences of the United States of ...
2003). "Identification of immunodominant regions among promiscuous HLA-DR-restricted CD4+ T-cell epitopes on the tumor antigen ... 2001). "Activation of melanoma antigen tumor antigens occurs early in lung carcinogenesis". Cancer Res. 61 (21): 7959-63. PMID ... Melanoma-associated antigen 3 (MAGE-A3) is a protein that in humans is encoded by the MAGEA3 gene. This gene is a member of the ... Guo J, Wen DR, Huang RR, et al. (2003). "Detection of multiple melanoma-associated markers in melanoma cell lines by RT in situ ...
Role of aberrant HLA-DR expression and antigen presentation in the induction of endocrine autoimmunity. Lancet ii: 1115-1119. " ... CS1 maint: discouraged parameter (link) "Professors Marc Feldmann and Sir Ravinder Maini Named Winners of the 2008 Dr. Paul ... the Dr. Paul Janssen Award for Biomedical Research; in 2010, the Ernst Schering Prize in Germany; in 2014, the Canada Gairdner ...
Studies on the polymorphisms of human leukocyte antigen (HLA)-DR and HLA-DQ gene regions in Sjögren's patients show ... Patients of different ethnic origin carry different HLA-susceptibility alleles, of which HLA-DR and HLA-DQ are involved in the ... HLA-DQ2 and HLA-B8 are generally found in Caucasian patients, while HLA-DR5 is related to Greek and Israeli patients. Multiple ... Dendritic cells are antigen-presenting cells that process antigen material and present it to other T cells. Following the ...
"HLA-DR, DQ genotypes of celiac disease patients and healthy subjects from the West of Ireland". Tissue Antigens. 47 (2): 127-33 ... The two subunits of the HLA-DQ protein are encoded by the HLA-DQA1 and HLA-DQB1 genes, located on the short arm of the sixth ... HLA-DQ is part of the MHC class II antigen-presenting receptor (also called the human leukocyte antigen) system and ... Almost all people (95%) with coeliac disease have either the variant HLA-DQ2 allele or (less commonly) the HLA-DQ8 allele.[28][ ...
A recombinant triplebody with specificity for CD19 and HLA-DR mediates preferential binding to antigen double-positive cells by ... Ärzteblatt.de Interview with Professor Dr. med. Dr. phil. Fuat S. Oduncu, MA, EMB, MBA (deutsch-tuerkisches-Wissenschaftsjahr. ... Erich-Frank-Gesellschaft Erich-Frank-Gesellschaft Christlicher Entwicklungsdienst Interview mit Professor Dr. med. Dr. phil. ... Later in 2005 he graduated with the degree of doctor of philosophy (Dr. phil.) at the Department of Philosophy of the LMU. He ...
... high-resolution and large sample typing of HLA DR-DQ haplotypes in a sample of European Americans". Tissue Antigens. 62 (4): ... The DQ loci are in close genetic linkage to HLA-DR, and less closely linked to HLA-DP, HLA-A, HLA-B and HLA-C. Different ... Recognize HLA-DQB1*02 gene products which include gene products of the following alleles: HLA-DQB1*02:01 HLA-DQB1*02:02 HLA- ... HLA-DQ (DQ) is encoded on the HLA region of chromosome 6p21.3, in what was classically known as the "D" antigen region. This ...
"HLA-DR antigens in pemphigus among Japanese". Tissue Antigens. 17 (2): 238-9. doi:10.1111/j.1399-0039.1981.tb00689.x. PMID ... HLA-DR4 (DR4) is an HLA-DR serotype that recognizes the DRB1*04 gene products. The DR4 serogroup is large and has a number of ... "HLA-DR specificities among Japanese with several autoimmune diseases". Tissue Antigens. 19 (2): 129-33. doi:10.1111/j.1399- ... Hermann R, Turpeinen H, Laine A, Veijola R, Knip M, Simell O, Sipilä I, Akerblom H, Ilonen J (2003). "HLA DR-DQ-encoded genetic ...
"HLA-DR antigens in rheumatoid arthritis. A Swiss collaborative study; final report. Swiss Federal Commission for the Rheumatic ... HLA-DR1 (DR1) is a HLA-DR serotype that recognizes the DRB1*01 gene products. It has been observed to be common among ... "Strong associations between specific HLA-DQ and HLA-DR alleles and the tubulointerstitial nephritis and uveitis syndrome". ... HLA-DR1 is not genetically linked to DR51, DR52 or DR53, but is linked to HLA-DQ1 and DQ5 serotypes. Fernández MM, Guan R, ...
... (DR15) is a HLA-DR serotype that recognizes the DRB1*1501 to *1505 and *1507 gene products. DR15 is found at high ... DR15 is part of the older HLA-DR2 serotype group which also contains the similar HLA-DR16 antigens. Serotypes are unknown for ... DQB1*0501 haplotype is associated with systemic lupus erythematosus HLA-DR15 is genetically linked to HLA-DR51 and HLA-DQ6 (HLA ... Ungar B, Mathews J, Tait B, Cowling D (1981). "HLA-DR patterns in pernicious anaemia". Br Med J (Clin Res Ed). 282 (6266): 768- ...
... high-resolution and large sample typing of HLA DR-DQ haplotypes in a sample of European Americans". Tissue Antigens. 62 (4): ... HLA-DQ7 (DQ7) is an HLA-DQ serotype that recognizes the common HLA DQB1*0301 and the less common HLA DQB1*0304 gene products. ... Waine GJ, Ross AG, Williams GM, Sleigh AC, McManus DP (1998). "HLA class II antigens are associated with resistance or ... HLA DQB1*0301 in Turks is associated with Thymoma but the risk may be associated with HLA class I loci. DQA1*0601:DQB1*0301 ( ...
"HLA-A, B and DR antigen frequencies in patients with AIDS-related persistent generalized lymphadenopathy (PGL) and ... HLA-DR5 (DR5) is a broad-antigen serotype that is further split into HLA-DR11 and HLA-DR12 antigen serotypes. With the ... "Association of progressive systemic scleroderma to several HLA-B and HLA-DR alleles". Arch Dermatol. 123 (9): 1188-91. doi: ... and increased longevity in the Dutch HLA-DR5 reactive gene products are linked to serology of HLA-DRB3 (HLA-DR52). derived from ...
... high-resolution and large sample typing of HLA DR-DQ haplotypes in a sample of European Americans". Tissue Antigens. 62 (4): ... HLA-DQ2 and HLA-DQB1*02 are almost synonymous in meaning. DQ2 β-chains combine with α-chains, encoded by genetically linked HLA ... HLA-DQ2 (DQ2) is a serotype group within HLA-DQ (DQ) serotyping system. The serotype is determined by the antibody recognition ... This haplotype, HLA A1-B8-DR3-DQ2, is associated with diseases in which HLA-DQ2 has suspect involvement. Direct involvement of ...
Pollack MS, Gold J, Metroka CE, Safai B, Dupont B (1984). "HLA-A,B,C and DR antigen frequencies in acquired immunodeficiency ... HLA-DR3 is composed of the HLA-DR17 and HLA-DR18 split 'antigens' serotypes. DR3 is a component gene-allele of the AH8.1 ... Type 1 diabetes mellitus is strongly associated with HLA-DR3 or HLA-DR4. Some DR3 also react with HLA-DR17 and/or HLA-DR18. The ... 2007). "Primary sclerosing cholangitis is associated with extended HLA-DR3 and HLA-DR6 haplotypes". Tissue Antigens. 69 (2): ...
Antigens most responsible for graft loss are HLA-DR (first six months), HLA-B (first two years), and HLA-A (long-term survival ... The complex of HLA-DR (Human Leukocyte Antigen - DR isotype ) and peptide, generally between 9 and 30 amino acids in length, ... HLA-DR is encoded by several loci and several 'genes' of different function at each locus. The DR α-chain is encoded by the HLA ... The HLA-DRB4 locus encodes the HLA-DR53 specificity, has some variation, and is associated with certain HLA-DRB1 types. The HLA ...
"HLA-DR, DQ nucleotide sequence polymorphisms in five Melanesian populations". Tissue Antigens. 40 (1): 31-37. doi:10.1111/j. ... Tanaka T, Ohmori M, Yasunaga S, Ohshima K, Kikuchi M, Sasazuki T (1999). "DNA typing of HLA class II genes (HLA-DR, -DQ and -DP ... HLA-DQ4 and HLA-DQB1*04 are almost synonymous in meaning. DQ4 β-chains combine with α-chains, encoded by genetically linked HLA ... The linkage of DQ4 in Asia appears to be heaviest with DR8 (DR*0801, DR*0802, DR*0804) for DQ4.24 and the frequency is elevated ...
"Frequencies of HLA-A, HLA-B, HLA-DR, and HLA-DQ phenotypes in the United Arab Emirates population". Tissue Antigens. 66 (2): ... HLA-DQ8 (DQ8) is a human leukocyte antigen serotype within the HLA-DQ (DQ) serotype group. DQ8 is a split antigen of the DQ3 ... Pimtanothai N, Hurley C, Leke R, Klitz W, Johnson A (2001). "HLA-DR and -DQ polymorphism in Cameroon". Tissue Antigens. 58 (1 ... October 2003). "New HLA haplotype frequency reference standards: high-resolution and large sample typing of HLA DR-DQ ...
HLA class II histocompatibility antigen, DR alpha chain is a protein that in humans is encoded by the HLA-DRA gene. HLA-DRA ... There are two different HLA-DRA chains in the human population coded by three different DRA alleles: HLA-DR ENSG00000228987, ... "Organization of the transcriptional unit of a human class II histocompatibility antigen: HLA-DR heavy chain". Nucleic Acids Res ... "Entrez Gene: HLA-DRA major histocompatibility complex, class II, DR alpha". Bénichou S, Benmerah A (2003). "[The HIV nef and ...
Wang JF, Zhang D, Zhao JZ, Jia BX, Bi RM (2006). "A study on the relationship between HLA-DR, DQ antigen, and intracranial ... HLA-DQ5 (DQ5) is a human leukocyte antigen serotype subgroup within HLA-DQ(DQ) serotypes. The serotype is determined by the ... HLA-DQ5 and HLA-DQB1*05 are almost synonymous in meaning. DQ5 β-chains combine with α-chains, encoded by genetically linked HLA ... A study on the relationship between HLA-DR, DQ antigen, and intracranial aneurysm in the Han nationality show DQ5 more likely, ...
... 和HLA-DR (人类T细胞的特异标志)。CTLA-4在活化T细胞表面的上调,对共激活受体有竞争性抑制作用,可以避免活化T细胞的过度活化。活化T细胞的表面糖基化情况也有改变[32]。 ... MR1 antigen presentation to mucosal-associated invariant T cells was highly conserved in evolution. Proceedings of the National ... An induced rebinding model of antigen discrimination. Trends Immunol. 2014, 35 (4): 153-8.
HLA-A, HLA-B, or HLA-C) increase the risk of graft rejection. A mismatch of an HLA Type II gene (i.e. HLA-DR, or HLA-DQB1) ... for human leukocyte antigen (HLA) matching (see PGD for HLA matching) in order to donate to an ill sibling requiring HSCT. ... A compatible donor is found by doing additional HLA-testing from the blood of potential donors. The HLA genes fall in two ... the donor should preferably have the same human leukocyte antigens (HLA) as the recipient. About 25 to 30 percent of allogeneic ...
"HLA-D related (DR) antigens in various kinds of myositis". Hum. Immunol. 3 (2): 181-6. doi:10.1016/0198-8859(81)90055-0. PMID ... Prior to refined typing for HLA-DQ and DR, the association with HLA-A1 and B8 was identified for coeliac disease in 1973 and ... "Correlation between acetylcholine receptor antibody titer and HLA-B8 and HLA-DRw3 antigens in myasthenia gravis". Trans Am ... November 1979). "Primary biliary cirrhosis associated with HLA-DRw3". Tissue Antigens. 14 (5): 449-52. doi:10.1111/j.1399- ...
HLA-DR, CD25, CD80 (B cells). Tests for T cell function: skin tests for delayed-type hypersensitivity, cell responses to ... This is carried out by using donor-derived antigen-presenting cells. These new methods have reduced culture time to 10-12 days ... recurrent infections and failure of the development of antibodies on exposure to antigens. The 1999 criteria also distinguish ... selective immunoglobulin A deficiency Specific antibody deficiency to specific antigens with normal B cell and normal Ig ...
Sokol DK, O'Brien RS, Wagenknecht DR, Rao T, McIntyre JA (2007). "Antiphospholipid antibodies in blood and cerebrospinal fluid ... that use recombinant antigens will not have a false-positive result. ... Genetic markers: HLA-B8, HLA-DR2, HLA-DR3. *Race: Blacks, Hispanics, Asians, and Native Americans ...
Stanworth DR (1993). "The discovery of IgE". Allergy. 48 (2): 67-71. doi:10.1111/j.1398-9995.1993.tb00687.x. PMID 8457034.. ... Binding of antigens to IgE already bound by the FcεRI on mast cells causes cross-linking of the bound IgE and the aggregation ... FcεRI is expressed on mast cells, basophils, and the antigen-presenting dendritic cells in both mice and humans. ... Conrad DH, Ford JW, Sturgill JL, Gibb DR (September 2007). "CD23: an overlooked regulator of allergic disease". Curr Allergy ...
HLA antigen.jpg 1.361 × 876; 124 KB. *. HLA region.jpg 1.104 × 653; 52 KB. ...
In these cases, patients should be tested for the presence of HLA-DQ2/DQ8 genetic markers because a negative HLA-DQ2 and HLA- ... There is evidence that not only gliadin (main cytotoxic antigen of gluten), but also other proteins present in gluten and ... "Wheat amylase trypsin inhibitors drive intestinal inflammation via activation of toll-like receptor 4". Journal of Experimental ... A 2015 systematic review showed that 20% of NCGS patients who presented with negative serology, HLA-DQ2 and/or HLA-DQ8 ...
... any antibody produced against this antigen (which mimics the self-antigens) can also, in theory, bind to the host antigens, and ... Klein J, Sato A (September 2000). "The HLA system. Second of two parts". N. Engl. J. Med. 343 (11): 782-6. doi:10.1056/ ... Edwards JC, Cambridge G, Abrahams VM (1999). "Do self perpetuating B lymphocytes drive human autoimmune disease?". Immunology. ... Molecular Mimicry - An exogenous antigen may share structural similarities with certain host antigens; thus, ...
City Museum: The Museum of the City was created by Dr. Néstor Rojas and offers a thorough investigation of the history, customs ... "Colonia Tovar: the history of a semi-isolated Venezuelan population of German ancestry described by HLA Class I genes". Tissue ... Antigens. 62 (5): 401-407. ISSN 0001-2815.. .mw-parser-output cite.citation{font-style:inherit}.mw-parser-output .citation q{ ...
Antigens presented on MHC 1 molecules activates CD8+ T cells on keratinocytes or by encounters with activated CD4+ helper T ... Dr Wilson explained the condition as an inflammatory disorder with unknown etiology. Initially, the characteristic surface ... It is associated with HLA-DQB1.[16][36] ... Autoimmune response to epithelial self-antigens remains a ... An immune-mediated mechanism where basal keratinocytes are being targeted as foreign antigens by activated T cells, especially ...
Dr Huisheng Ai, Guo Mei, etc. developed a new regimen of reduced-intensity chemotherapy plus G-CSF mobilized HLA-mismatched ... mobilized human leukocyte antigen (HLA)-mismatched allogeneic peripheral blood stem cells following a reduced-intensity ... Led by Dr. Huisheng Ai and his medical team at MST International Clinic for Leukemia in the 307th Hospital of Chinese People's ... Matched HLA between donor and recipient is not necessary. The stem cells are collected from donor's blood through a process ...
HLA-B12, HLA-B51, HLA-Cw7, HLA-A2, HLA-A11, and HLA-DR2 are examples of human leukocyte antigen types associated with aphthous ... McBride DR (July 2000). "Management of aphthous ulcers". American Family Physician. 62 (1): 149-54, 160. PMID 10905785.. ... or present a more substantial barrier to microbes and antigens, but this is unclear. Nicotine is also known to stimulate ... stomatitis.[2][5] However, these HLA types are inconsistently associated with the condition, and also vary according to ...
They are HLA-A, HLA-B, (both Class I MHCs) and HLA-DR (a Class II MHC).[5] If the two tissues have the same genes coding for ... HLA-B is part of a family of genes called the human leukocyte antigen (HLA) complex. The HLA complex helps the immune system ... HLA-B*45ZJ, HLA-B-3506, HLA-B-3905, HLA-B-5502, HLA-B-5602, HLA-B15, HLA-B39, HLA-B49, HLA-B50, HLA-B55, HLA-B59, HLA-B61, HLA- ... In humans, the HLA-B gene and two related genes, HLA-A and HLA-C, are the major genes in MHC class I. ...
HLA)). This MHC: antigen complex is recognized by T-cells passing through the lymph node. Exogenous antigens are usually ... HIV is able to subvert the immune system by specifically attacking the CD4+ T cells, precisely the cells that could drive the ... Exogenous antigensEdit. Antigen presentation stimulates T cells to become either "cytotoxic" CD8+ cells or "helper" CD4+ cells. ... Antigen presentationEdit. Main article: Antigen presentation. Acquired immunity relies on the capacity of immune cells to ...
"Recommendations for HLA-B*15:02 and HLA-A*31:01 genetic testing to reduce the risk of carbamazepine-induced hypersensitivity ... Dr. Okuma, working independently, did the same thing with success. As they were also epileptologists, they had some familiarity ... or toxic epidermal necrolysis due to carbamazepine therapy are more common in people with a particular human leukocyte antigen ... U.S. National Center for Biotechnology Information: Medical Genetics Summaries - Carbamazepine therapy and HLA genotype ...
Dr Ayush Goel, dr Mohammed Izhar jt,Thymolipoma. *Helena Nunes-Cabaço, Paula Matoso, Russell B. Foxall, Rita Tendeiro, Ana R. ... Autoreactive thymic B cells are efficient antigen-presenting cells of cognate self-antigens for T cell negative selection., 110 ... Jørgensen A, Röpke C, Nielsen M, Madsen H, Svejgaard A, Odum N., Human thymic epithelial cells express functional HLA-DP ... Professor Dr.Dr.h.c. Herwart F. Otto, Anmerkungen zur Geschichte der Thymusforschung, Pathologie des Thymus, Springer Texts in ...
Organ transplants are not regulated by the FDA.[138] It is essential that the HLA complexes of both the donor and recipient be ... Dr. Jacob Lavee, head of the heart-transplant unit, Sheba Medical Center, Tel Aviv, believes that "transplant tourism" is ... and that they have low levels of T cell-independent antigens.[17][19] United Network for Organ Sharing (UNOS) regulations allow ... The surgery was done by Dr. Joseph Murray, who received the Nobel Prize in Medicine for his work. The reason for his success ...
"Frequencies of HLA-A, HLA-B, HLA-DR, and HLA-DQ phenotypes in the United Arab Emirates population". Tissue Antigens. 66 (2): ... HLA-DR *α-chain encoded by HLA-DRA locus. *4 β-chains (only 3 possible per person), encoded by HLA-DRB1, DRB3, DRB4, DRB5 loci ... HLA-C. Minor genes are HLA-E, HLA-F and HLA-G. β2-microglobulin binds with major and minor gene subunits to produce a ... HLA-DQ2 and HLA-DQ8. Coeliac disease. 7[6]. In autoimmunity[edit]. HLA types are inherited, and some of them are connected with ...
Green DR, Ware CF (juni 1997). "Fas-ligand: privilege and peril". Proc Natl Acad Sci USA. 94 (12): 5986-90. Bibcode:1997PNAS... ... Transplantirano tkivo, tijelo obično prepoznaje kao strani antigen i napada ga imunskim sistemom. Međutim, na imunki ...
... by Dr. Saul Greenberg. University of Toronto. Last updated, on February 5, 2009 ...
Since NK cells recognize target cells when they express nonself HLA antigens (but not self), autologous (patients' own) NK cell ... published study to assert that untreated lymphoid cells were able to confer a natural immunity to tumors was performed by Dr. ... HLA-A, HLA-B, HLA-C) and nonclassical Mamu-G (HLA-G) in primates. Some KIRs are specific for certain HLA subtypes. Most KIRs ... Certain HLA allotypes have been found to determine the progression of HIV to AIDS; an example is the HLA-B57 and HLA-B27 ...
This is owing to the high frequency of the HLA-B27 gene in the white population.[8][9] It can occur in epidemic form. Patients ... Dr. Reiter's Nazi Party affiliation, and in particular his involvement in forced human experimentation in the Buchenwald ... See also: List of human leukocyte antigen alleles associated with cutaneous conditions ... A blood test for the genetic marker HLA-B27 may also be performed. About 75 percent of all the patients with Reiter's arthritis ...
Seliger B, Ritz U, Ferrone S (2006). "Molecular mechanisms of HLA class I antigen abnormalities following viral infection and ... Flower DR, Doytchinova IA. (2002). "Immunoinformatics and the prediction of immunogenicity". Appl Bioinformatics. 1 (4): 167-76 ... oleh pengenal antigen.[59] Respons imun adaptif bersifat spesifik terhadap antigen tertentu dan membutuhkan pengenalan antigen ... Oleh sistem imun, antigen tersebut dianggap sebagai antigen asing dan keberadaannya mendorong sel imun untuk menyerang sel ...
for major contributions to the understanding of the key antigen-specific molecules, the T cell receptor for antigen and ... for discovering the HL-A system, the major histocompatibility complex in man and its primordial role in organ transplantation. ... carry somatically mutated genes-oncogenes that operate to drive their malignant proliferation. ... for discovery of H-2 antigens, which codes for major transplantation antigens and the onset of the immune response. ...
IFN-γ drives Th1 cell production while IL-10 and IL-4 inhibit Th1 cell production. Conversely, IL-4 drives Th2 cell production ... For example, when an antigen-presenting cell expresses an antigen on MHC class II, a CD4+ cell will aid those cells through a ... that a host antigen is foreign. As a result, the CD8+ T cells treat the host cell presenting that antigen as infected, and go ... but unprocessed antigens do not interact with T cells and are not involved in their activation. The antigens that bind to MHC ...
Holding Line HLA - (i) High Level Architecture (simulation) - Human Leukocyte Antigen HLL - (i) High-Level Language HLN - (i) ... Hard Disk Drive High-Density Disk HDL - (i) High-Density Lipoprotein HDM - (i) Human Decision-Making HDMI - High Definition ...
Markers of T cell activation include CD69, CD71 and CD25 (also a marker for Treg cells), and HLA-DR (a marker of human T cell ... Antigen-naïve T cells expand and differentiate into memory and effector T cells after they encounter their cognate antigen ... T cell exhaustion can be triggered by several factors like persistent antigen exposure and lack of CD4 T cell help.[51] Antigen ... Antigen discriminationEdit. A unique feature of T cells is their ability to discriminate between healthy and abnormal (e.g. ...
... human leukocyte antigen (HLA) alleles from the archaic Denisovan and Neanderthal genomes were found to show patterns in the ... Begun, DR. (2013). "The Past, Present and Future of Palaeoanthropology". In: A Companion to Paleoanthropology. Wiley-Blackwell ... Dr. Phillip Habgood discovered that the characters said to be unique to the Australasian region by Thorne are plesiomorphic: ... the ancestry from these archaic alleles at the HLA-A site was more than 50% for modern Europeans, 70% for Asians, and 95% for ...
HLA-DR antigens in small and large intestinal epithelia were examined in Crohns disease (CD). Seventy-two biopsy specimens (10 ... Crohns disease elemental diet HLA-DR antigens large intestine small intestine This work was partly supported by a grant from ... HLA-DR antigens in small and large intestinal epithelia were examined in Crohns disease (CD). Seventy-two biopsy specimens (10 ... Fais S, Pallone F, Squarcia O, et al: HLA-DR antigens on colonic epithelial cells in inflammatory bowel disease: I. Relation to ...
MHC class II molecule interacts with HLA_DM, and HLA_DO in B-cells, in order to release CLIP and facilitate the binding of ... In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) ... Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the ... also to express HLA-DO. Lysosomal microenvironment has been implicated in the regulation of antigen loading into MHC II ...
Electrophoretic analysis of human HLA-DR antigens from HLA-DR4 homozygous cell lines: correlation between beta-chain diversity ... Electrophoretic analysis of human HLA-DR antigens from HLA-DR4 homozygous cell lines: correlation between beta-chain diversity ... Electrophoretic analysis of human HLA-DR antigens from HLA-DR4 homozygous cell lines: correlation between beta-chain diversity ... Electrophoretic analysis of human HLA-DR antigens from HLA-DR4 homozygous cell lines: correlation between beta-chain diversity ...
Downs syndrome and celiac disease: the prevalence of high IgA-antigliadin antibodies and HLA-DR and DQ antigens in trisomy 21. ... HLA-DR and -DQ antigens were also determined in 75 DS patients (20 with high and 55 with normal IgA-AGA levels), and the ... HLA-DQ Antigens/genetics. *HLA-DR Antigens/analysis*. *HLA-DR Antigens/genetics ...
HLA class II histocompatibility antigen, DR beta 3 chain - P79483 (DRB3_HUMAN) ... MHC class II molecule interacts with HLA_DM, and HLA_DO in B-cells, in order to release CLIP and facilitate the binding of ... In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) ... Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the ...
HLA-DR+CD56dim NK cells showed higher IFNγ production and degranulation level than the respective HLA-DR− NK cells in response ... HLA DR+CD56dim NK cells showed higher IFNγ production and degranulation level than the respective HLA-DR‒ NK cells in response ... cytokine-activated HLA-DR-expressing NK cells were able to mediate mycobacteria-induced and HLA-DR-dependent cytokine ... cytokine-activated HLA-DR-expressing NK cells were able to mediate mycobacteria-induced and HLA-DR-dependent cytokine ...
METHODS: The relation between silver staining patterns of nucleoli and HLA-DR antigen expression was examined in alveolar ... Correlation of morphological patterns of nucleoli in alveolar macrophages with HLA-DR antigen expression in sarcoidosis. ... Correlation of morphological patterns of nucleoli in alveolar macrophages with HLA-DR antigen expression in sarcoidosis. ... described as a sensitive indicator of cellular activity a study was performed to examine whether it relates to HLA-DR antigen ...
AM of smokers were more heterogeneous in respect to cell size, autofluorescence, and HLA-DR antigen expression. HLA-DR antigen ... HLA-DR antigen expression in AM of different maturational states and that this defective expression of HLA class II antigens is ... Human alveolar macrophages: comparison of cell size, autofluorescence, and HLA-DR antigen expression in smokers and nonsmokers ... and expressed fewer HLA-DR antigens (p , 0.001) compared with AM of nonsmokers. ...
HLA class II histocompatibility antigen, DR beta 5 chain [Golgi membrane] HLA class II histocompatibility antigen, DR beta 5 ... HLA II beta chain [plasma membrane] (Sus scrofa) * Homologues of HLA class II histocompatibility antigen, DR beta 5 chain [ ... HLA II beta chain [plasma membrane] (Sus scrofa) * Homologues of HLA class II histocompatibility antigen, DR beta 5 chain [ ... HLA II beta chain [plasma membrane] (Sus scrofa) * Homologues of HLA class II histocompatibility antigen, DR beta 5 chain [ ...
HLA-DR-dependent, MHC-restricted antigen-presentation and IL-1 alpha expression.. P F Weller, T H Rand, T Barrett, A Elovic, D ... HLA-DR-dependent, MHC-restricted antigen-presentation and IL-1 alpha expression. ... HLA-DR-dependent, MHC-restricted antigen-presentation and IL-1 alpha expression. ... HLA-DR-dependent, MHC-restricted antigen-presentation and IL-1 alpha expression. ...
HLA-DR Antigens and DQ Beta Chain Gene Probing in Insulin Dependent Diabetics of Asian Origin J.A. Fletcher ; J.A. Fletcher ... J.A. Fletcher, C. Mijovic, O. Odugbesan, E. Mackay, A.R. Bradwell, A.H. Barnett; HLA-DR Antigens and DQ Beta Chain Gene Probing ... Adventitial recruitment of Lyve-1- macrophages drives aortic aneurysm in an angiotensin-2-based murine model. ...
HLA class II histocompatibility antigen, DR beta 5 chain [Golgi membrane] HLA class II histocompatibility antigen, DR beta 5 ... HLA II beta chain [lysosomal membrane] (Homo sapiens) * HLA class II histocompatibility antigen, DR beta 5 chain [lysosomal ... HLA II beta chain [lysosomal membrane] (Homo sapiens) * HLA class II histocompatibility antigen, DR beta 5 chain [lysosomal ... HLA II beta chain [lysosomal membrane] (Homo sapiens) * HLA class II histocompatibility antigen, DR beta 5 chain [lysosomal ...
Matching for HLA AB or DR antigens alone failed to yield subgroups with significant differences in graft outcome. However, with ... support a role for tissue matching in cadaver transplantation and suggest that combined matching for HLA AB and DR antigens may ... combined HLA AB and DR matching criteria, a subgroup of 0 DR, , 2 AB matched recipients was identified with significantly ... AbstractThis is a retrospective analysis of the results of HLA AB and DR antigen matching in 56 transfused cadaver transplant ...
Tag: Mouse monoclonal to HLA-DR.HLA-DR a human class II antigen of the major histocompatibility complexMHC). The bacterial cell ... In comparison to Mouse monoclonal to HLA-DR.HLA-DR a human class II antigen of the major histocompatibility complex(MHC),is a ... Mouse monoclonal to HLA-DR.HLA-DR a human class II antigen of the major histocompatibility complexMHC), PHA-665752 ... HLA-DR is also expressed on activated T cells. This molecule plays a major role in cellular interaction during antigen ...
Costabel, U., Bross, K. J., Andreesen, Reinhard and Matthys, H. (1986) HLA-DR antigens on human macrophages from ... The expression of HLA-DR (Ia-like) antigens on human macrophages was investigated by analyses of cells from bronchoalveolar ... The expression of HLA-DR (Ia-like) antigens on human macrophages was investigated by analyses of cells from bronchoalveolar ... The HLA-DR antigen was demonstrated by the mouse monoclonal antibody OKIa by a peroxidase-antiperoxidase method performed on ...
Soluble bivalent HLA-DR2.MBP peptide complexes activated antigen-specific T-cells in the absence of antigen presenting cells. ... These results demonstrate that bivalent HLA-DR. peptide complexes represent effective ligands for activation of the TCR. The ... arms of an IgG2a antibody with HLA-DR2.MBP peptide complexes. The binding of bivalent HLA-DR2.peptide complexes to recombinant ... Soluble bivalent HLA-DR2.myelin basic protein (MBP) peptide complexes were expressed by replacing the F(ab) ...
We have shown earlier that HLA-DR antigens are encoded by two distinct loci, DR beta I and DR beta III. The alloantigenic ... Functional polymorphism of each of the two HLA-DR beta chain loci demonstrated with antigen-specific DR3- and DRw52-restricted ... HLA class II regulation and structure. Analysis with HLA-DR3 and HLA-DP point mutants. ... Functional polymorphism of each of the two HLA-DR beta chain loci demonstrated with antigen-specific DR3- and DRw52-restricted ...
HLA-DR antigen expression in colorectal carcinomas: influence of expression by IFN-gamma in situ and its association with ... The expression of HLA-DR antigen on AN was significantly increased compared with RN. Patients with tumours showing HLA-DR ... The expression of HLA-DR antigen on Ca and on normal epithelia, both on AN and those 5-10 cm removed from the carcinoma (RN), ... Detection in carcinoma tissues of IFN-gamma mRNA that leads to the induction of HLA-DR antigen on AN could be an indicator of a ...
Identification of a human Ia antigen that is different from HLA-DR and DC antigens ... Identification of a human Ia antigen that is different from HLA-DR and DC antigens ... Identification of a human Ia antigen that is different from HLA-DR and DC antigens ...
HLA Class II (DR) Antigen Primary Antibodies HLA Class II (DR) Antigen Novocastra. *Product ... Antigen Background HLA-DR is an MHC Class II antigen that maps to chromosome 6. It is a heterodimer composed of 2 non- ... Human anaplastic lymphoma: immunohistochemical staining for HLA class II antigen using NCL-LN3. Note membrane staining of large ... It is reported to be expressed mainly on antigen-presenting cells (monocytes/macrophages and dendritic cells), B cells and some ...
... as the HLA-DR antigen was lost at relapse in only 4% of HLA-DR-positive cases, and was gained at relapse in only 17% of HLA-DR- ... as the HLA-DR antigen was lost at relapse in only 4% of HLA-DR-positive cases, and was gained at relapse in only 17% of HLA-DR- ... as the HLA-DR antigen was lost at relapse in only 4% of HLA-DR-positive cases, and was gained at relapse in only 17% of HLA-DR- ... as the HLA-DR antigen was lost at relapse in only 4% of HLA-DR-positive cases, and was gained at relapse in only 17% of HLA-DR- ...
... were HLA-DR positive (p less than 0.0001). Epithelial cells were uniformly HLA-DR negative in specimens from normal control ... The expression of HLA-DR antigen in mucosal epithelial cells was strongly related to whether the specimens were actively ... were examined by histological and immunohistochemical methods using monoclonal antibodies to the beta chain of HLA-DR antigen. ... Epithelial cells in specimens from patients with ulcerative colitis, Crohns disease, and radiation colitis were HLA-DR ...
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title = "Antigen-specific T cells with monogamous or promiscuous restriction patterns are sensitive to different HLA-DRβ chain ... T1 - Antigen-specific T cells with monogamous or promiscuous restriction patterns are sensitive to different HLA-DRβ chain ... Antigen-specific T cells with monogamous or promiscuous restriction patterns are sensitive to different HLA-DRβ chain ... Antigen-specific T cells with monogamous or promiscuous restriction patterns are sensitive to different HLA-DRβ chain ...
The HLA-DR phenotype modulates the humoral immune response to enterovirus antigens.. Sadeharju K1, Knip M, Hiltunen M, Akerblom ... Diabetes-associated HLA-DR risk alleles were associated with a strong immune responsiveness and protective alleles with a weak ... Children with either the HLA-DR3 or HLA-DR4 allele and those with both these risk alleles had higher Coxsackie B4 antibody ... Study and carrying either HLA-DR risk (DR3 and/or DR4) or protective (DR2) alleles. ...
Thus the HLA-DR and DC specificities as defined by alloantisera, could represent groups of antigens which are controlled by HLA ... Whereas serological analysis and mixed lymphocyte typing have defined three polymorphic families of Ia antigens, HLA-DR, -DC ... of the Ia antigens expressed on the cell surface of an HLA homozygous line PGF. ... Here, we have used a monoclonal antibody specific for HLA-DR2 to show that this determinant is carried by molecules which are ...
HLA-DR antigens were found on the epithelium of only one of six patients with ulcerative colitis in remission and one of three ... Colonic epithelial cells from all 21 control subjects with histologically normal colonic mucosa were HLA-DR-. In contrast, in ... Moreover, these antigens were not present on the epithelium of non-inflamed colonic mucosa in two patients with Crohns disease ... C antigens by human colonic epithelium has been examined in tissue sections of patients with inflammatory bowel disease using ...
An antiserum to HLA-B8 demonstrated suppressor activity associated with the presence ... We have observed that certain antisera to HLA antigens suppress the in vitro proliferation of lymphoblastoid cell lines. ...
Circulating HIV-specific CD8+ cytotoxic T cells express CD38 and HLA-DR antigens. en_US. ...
HLA-DR antigen frequencies in a North Indian type I diabetic population. Together they form a unique fingerprint. * HLA-DR ... and 113 unaffected individuals were typed for HLA-DR antigens from DR1 to DR7. The frequency of HLA-DR3 was significantly ... and 113 unaffected individuals were typed for HLA-DR antigens from DR1 to DR7. The frequency of HLA-DR3 was significantly ... and 113 unaffected individuals were typed for HLA-DR antigens from DR1 to DR7. The frequency of HLA-DR3 was significantly ...
  • Furthermore, we have recently recognized by DNA sequencing three alleles of HLA-DRw52 at locus DR beta III, referred to as 52 a, b, and c. (rupress.org)
  • Our objective was to correlate the pattern of T cell restriction with the gene products of individual DR beta chain loci and with the three newly described alleles of locus DR beta III. (rupress.org)
  • Because this suggested a correlation with the pattern of DRw52 polymorphism observed earlier by DNA sequencing and oligonucleotide hybridization, the APC used in these experiments were typed for the 52 a, b, and c alleles of locus DR beta III by allele-specific oligonucleotide probes. (rupress.org)
  • The aim of this study was to evaluate virus-host interaction by analysing the enterovirus antibody levels in subjects carrying different HLA-DR alleles associated with either increased or decreased risk of Type 1 diabetes. (cdc.gov)
  • Study subjects included siblings of children with Type 1 diabetes taking part in the Childhood Diabetes in Finland (DiMe) Study and carrying either HLA-DR risk (DR3 and/or DR4) or protective (DR2) alleles. (cdc.gov)
  • Children with either the HLA-DR3 or HLA-DR4 allele and those with both these risk alleles had higher Coxsackie B4 antibody levels than children carrying the HLA-DR2 allele ( p=0.01, p=0.01 and p=0.008, respectively). (cdc.gov)
  • Diabetes-associated HLA-DR risk alleles were associated with a strong immune responsiveness and protective alleles with a weak responsiveness against enterovirus antigens. (cdc.gov)
  • Immune-mediated diseases strongly associating with human leukocyte antigen (HLA) alleles are likely linked to specific antigens. (scilifelab.se)
  • We have also examined whether the colocalization induces internalization of HLA-DR using HA(307-319), a "universal" peptide that binds specifically to the peptide-binding groove of all HLA-DR molecules, irrespective of their alleles. (york.ac.uk)
  • https://maria.stanford.edu/ ), a multimodal recurrent neural network for predicting the likelihood of antigen presentation from a gene of interest in the context of specific HLA class II alleles. (nature.com)
  • The association with HLA-DRB1 alleles was tested in 609 Continental Italian MS patients and 836 controls. (biomedsearch.com)
  • Researchers have identified hundreds of different versions (alleles) of the HLA-DRB1 gene, each of which is given a particular number (such as HLA-DRB1 *04:01). (medlineplus.gov)
  • HLA-DQ alleles and susceptibility to celiac disease in Spanish children. (nih.gov)
  • Human leukocyte antigen alleles and haplotypes associated with selective immunoglobulin A deficiency in Spanish pediatric patients. (nih.gov)
  • Restriction fragment length polymorphism analysis of HLA-DR- and DQ-linked alleles in multiple sclerosis in Spain. (nih.gov)
  • The two other alleles were HLA.DRB4*01 at 35.7% and HLA-DQB1*0501 at 28.6%, as detected in each of the clinical and radiological manifestations. (scielo.org.co)
  • The alleles HLA-B27, HLA-DRB4*01 and HLA-DQB1*0501 were common in the different subtypes of spondyloarthritis and were frequent in the specific clinical axial, peripheral and extraarticular clinical manifestations, as well as radiological sacroiliitis. (scielo.org.co)
  • Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. (rcsb.org)
  • To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. (rcsb.org)
  • HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. (rcsb.org)
  • In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. (rcsb.org)
  • Lysosomal microenvironment has been implicated in the regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and efficient peptide loading. (rcsb.org)
  • 3 MHC class II molecules bind to a CD74 homotrimer (also known as invariant chain or HLA class II histocompatibility antigen gamma chain). (rcsb.org)
  • Here, we have used a monoclonal antibody specific for HLA-DR2 to show that this determinant is carried by molecules which are distinct from those of the DC series and which represent 30% of the Ia antigens expressed on the cell surface of an HLA homozygous line PGF. (ox.ac.uk)
  • These antigens are presented to T cells in the form of peptides bound to HLA molecules on antigen presenting cells, e.g. dendritic cells, macrophages or B cells. (scilifelab.se)
  • These polypeptides were shown to be different molecules on the basis of their separation on NEPHGE/SDS-PAGE analysis, their rates of turnover relative to the other polypeptides of the HLA-DR-associated antigens, and their noncoordinate alteration in position on NEPHGE/SDS-PAGE two-dimensional analysis of different cell lines. (ox.ac.uk)
  • These studies indicate that alveolar macrophages are less effective than blood monocytes are as stimulator cells in autologous MLR and that, although the masking of HLA-DR molecules results in inhibition of autologous MLR, T-cell proliferation is not dependent on the numbers of stimulator cells bearing HLA-DR antigens. (elsevier.com)
  • Functionally, embryonic antigen-presenting cells (APCs) are able to phagocytose antigen, to up-regulate costimulatory molecules upon culture, and to efficiently stimulate T cells in a mixed lymphocyte reaction. (rupress.org)
  • Skin macrophages, in contrast, express low levels of HLA-DR molecules and lack CD1c ( 6 , 9 ). (rupress.org)
  • Major histocompatibility complex (MHC) class II-associated antigen presentation involves an array of interacting molecules. (york.ac.uk)
  • To address this, we have employed a high-resolution single-particle imaging method for quantifying the colocalization of CD74 with human leukocyte antigen (HLA)-DR molecules on human fibroblast cells known for their capacity to function as antigen-presenting cells. (york.ac.uk)
  • Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). (cancerindex.org)
  • An essential role for HLA-DM in antigen presentation by class II major histocompatibility molecules. (springer.com)
  • The extracellular domains of MHC class II molecules determine their processing requirements for antigen presentation. (springer.com)
  • HLA-DR molecules from an antigen-processing mutant cell line are associated with invariant chain peptides. (springer.com)
  • Invariant chain peptides in most HLA-DR molecules of an antigen-processing mutant. (springer.com)
  • Accurate prediction of antigen presentation by human leukocyte antigen (HLA) class II molecules would be valuable for vaccine development and cancer immunotherapies. (nature.com)
  • T cell antigen receptor recognition of antigen-presenting molecules. (ebi.ac.uk)
  • Additional experiments utilizing a panel of quantitative assays specific for nine additional common DR molecules identified a large set of DR molecules, which includes at least the DRB1*0101, DRB1*0401, DRB1*0701, DRB5*0101, DRB1*1501, DRB1*0901, and DRB1*1302 allelic products, characterized by overlapping peptide-binding repertoires. (jimmunol.org)
  • More than 200 different types of HLA class I and class II molecules have already been identified ( 64 , 65 ). (jimmunol.org)
  • HLA genes encode cell surface molecules specialized to present antigenic peptides to T-cell receptors. (biomedcentral.com)
  • HLA-DR, like other MHC class II molecules, is a transmembrane glycoprotein composed of a 36 kDa alpha chain (DRA) and 27 kDa beta chain (DRB). (thermofisher.com)
  • Correlation of morphological patterns of nucleoli in alveolar macrophages with HLA-DR antigen expression in sarcoidosis. (bmj.com)
  • BACKGROUND: Alveolar macrophages from patients with sarcoidosis express increased quantities of HLA-DR during activation. (bmj.com)
  • METHODS: The relation between silver staining patterns of nucleoli and HLA-DR antigen expression was examined in alveolar macrophages collected by bronchoalveolar lavage from 11 patients with pulmonary sarcoidosis and 11 control subjects. (bmj.com)
  • The number of silver stained dots in alveolar macrophages correlated significantly with the intensity and the density of HLA-DR antigen expression in the patients with sarcoidosis. (bmj.com)
  • Mouse monoclonal to HLA-DR.HLA-DR a human class II antigen of the major histocompatibility complex(MHC),is a transmembrane glycoprotein composed of an alpha chain (36 kDa) and a beta subunit(27kDa) expressed primarily on antigen presenting cells:B cells, monocytes, macrophages and thymic epithelial cells. (cylch.org)
  • The expression of HLA-DR (Ia-like) antigens on human macrophages was investigated by analyses of cells from bronchoalveolar lavage fluid obtained from 12 patients with pulmonary sarcoidosis, six patients with extrinsic allergic alveolitis, nine patients with cryptogenic fibrosing alveolitis, 11 normal non-smokers, and 12 normal smokers. (uni-regensburg.de)
  • No differences were found in the percentage of alveolar macrophages that expressed DR antigens between the five study groups. (uni-regensburg.de)
  • These observations suggest that the previously reported enhanced antigen presentation by alveolar macrophages in sarcoidosis is not linked with an increase in the percentage of DR+ macrophages in the lung. (uni-regensburg.de)
  • It is reported to be expressed mainly on antigen-presenting cells (monocytes/macrophages and dendritic cells), B cells and some activated T cells. (leicabiosystems.com)
  • Epithelial cells were uniformly HLA-DR negative in specimens from normal control patients despite the presence of HLA-DR positive lymphoid cells and macrophages in the lamina propria. (ox.ac.uk)
  • Most macrophages and lymphocytes in IRF and NF immunostained Strangly for HLA-DR antigens . (bvsalud.org)
  • Because the autologous mixed lymphocyte reaction (MLP), in which HLA-DR-positive non-T cells stimulate the proliferation of autologous T lymphocytes, represents a good model to study macrophage-T cell interaction, we examined and compared the ability of human alveolar macrophages and peripheral blood-derived monocytes to induce T-cell proliferation in autologous MLR. (elsevier.com)
  • Macrophages and T lymphocytes demonstrated a marked expression of HLA-DR antigen. (wikipedia.org)
  • CD74 is expressed primarily by antigen presenting cells, such as B-lymphocytes (from before the pre-B cell stage to before the plasma cell stage), macrophages, and monocytes, and many epithelial cells. (novusbio.com)
  • Description: The LN3 mAb reacts with the human major histocompatibility complex (MHC) class II, HLA-DR. HLA-DR is expressed on the surface of human antigen presenting cells (APC) including B cells, monocytes, macrophages, DCs, and activated T cells. (thermofisher.com)
  • HLA-DR is expressed primarily on antigen presenting cells such as B lymphocytes, monocytes, macrophages, thymic epithelial cells and activated T lymphocytes. (thermofisher.com)
  • The HLA system belongs to the major histocompatibility complex (MHC) in humans and it is located on chromosome 6p21.3. (biomedcentral.com)
  • Binds peptides derived from antigens that access the endocytic route of antigen presenting cells ( APC ) and presents them on the cell surface for recognition by the CD4 T-cells. (rcsb.org)
  • MHC class II molecule interacts with HLA_DM, and HLA_DO in B-cells, in order to release CLIP and facilitate the binding of antigenic peptides. (rcsb.org)
  • Approach for Identifying Human Leukocyte Antigen (HLA)-DR Bound Peptides from Scarce Clinical Samples. (scilifelab.se)
  • The identification of HLA-DR-bound peptides presents a valuable tool to investigate the human immunopeptidome. (scilifelab.se)
  • This makes the lung of exceptional interest and presents an ideal paradigm to study the human immunopeptidome and to identify antigenic peptides.Our previous investigation of HLA-DR peptide presentation in the lung required high numbers of cells (800 × 10(6) bronchoalveolar lavage (BAL) cells). (scilifelab.se)
  • Because BAL from healthy nonsmokers typically contains 10-15 × 10(6) cells, there is a need for a highly sensitive approach to study immunopeptides in the lungs of individual patients and controls.In this work, we analyzed the HLA-DR immunopeptidome in the lung by an optimized methodology to identify HLA-DR-bound peptides from low cell numbers. (scilifelab.se)
  • This work presents an optimized approach designed to identify HLA-DR-bound peptides from low numbers of cells, enabling the investigation of the BAL immunopeptidome from individual patients and healthy controls in order to identify disease-associated peptides. (scilifelab.se)
  • Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal/lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place. (uniprot.org)
  • Fig. 4: MARIA trained on human HLA-DQ ligand peptides identified celiac-related gluten antigens. (nature.com)
  • The peptide binding specificities of HLA-DRB1*0401, DRB1*0101, and DRB1*0701 have been analyzed by the use of large collections of synthetic peptides corresponding to naturally occurring sequences. (jimmunol.org)
  • The CD74 molecule plays a critical role in the presentation of peptides, by the MHC class II antigens, to CD4 positive lymphocytes. (novusbio.com)
  • HLA-DR is a heterodimeric transmembrane protein composed of alpha and beta subunits and plays an important role in the presentation of peptides to CD4+ T lymphocytes. (thermofisher.com)
  • Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL , leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). (rcsb.org)
  • Kinetics of T-cell receptor binding by bivalent HLA-DR. Peptide complexes that activate antigen-specific human T-cells. (semanticscholar.org)
  • Soluble bivalent HLA-DR2.myelin basic protein (MBP) peptide complexes were expressed by replacing the F(ab) arms of an IgG2a antibody with HLA-DR2.MBP peptide complexes. (semanticscholar.org)
  • Fling SP, Arp B, Pious D. HLA-DMA and -DMB genes are both required for MHC class II/peptide complex formation in antigen-presenting cells. (springer.com)
  • Invariant-cognate peptide exchange restores class II dimer stability in HLA-DM mutants. (springer.com)
  • In addition to in vitro binding measurements, MARIA is trained on peptide HLA ligand sequences identified by mass spectrometry, expression levels of antigen genes and protease cleavage signatures. (nature.com)
  • These results have implications for understanding the molecular interactions involved in peptide-DR binding, as well as the genetic and structural basis of MHC polymorphism. (jimmunol.org)
  • Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. (thermofisher.com)
  • Primary dendritic cells (DCs) also to express HLA-DO. (rcsb.org)
  • We also found that CD45 + HLA-DR high CD1c + dendritic cells (DCs) are already present in the epidermis and dermis at 9 wk estimated gestational age (EGA) and that transforming growth factor β1 production precedes Langerin and CD1a expression on CD45 + CD1c + Langerhans cell (LC) precursors. (rupress.org)
  • A similar inhibition of HLA-DR internalization was observed in freshly isolated monocyte-derived dendritic cells. (york.ac.uk)
  • Thus the HLA-DR and DC specificities as defined by alloantisera, could represent groups of antigens which are controlled by HLA genes in linkage disequilibrium. (ox.ac.uk)
  • This finding is compatible with the location of at least one of the HLA-D/DR heavy chain genes within the HLA region. (ox.ac.uk)
  • Genes in the MHC that may affect antigen processing. (springer.com)
  • Defective processing and presentation of exogenous antigens in mutants with normal HLA class II genes. (springer.com)
  • The HLA-DRB1 gene is part of a family of genes called the human leukocyte antigen (HLA) complex. (medlineplus.gov)
  • The HLA-DRB1 gene belongs to a group of MHC genes called MHC class II. (medlineplus.gov)
  • 40 different risk genes, with HLA genes contributing more than half of the genetic susceptibility. (diabetesjournals.org)
  • However, the global distribution of HLA-B27 varies considerably and furthermore, associations with non-HLA-B27 genes have been described. (scielo.org.co)
  • The HLA-DR antigen was demonstrated by the mouse monoclonal antibody OKIa by a peroxidase-antiperoxidase method performed on glass slides. (uni-regensburg.de)
  • The HLA-DR-associated antigens were isolated by immunoprecipitation using a monoclonal anti-DR antibody, TDR31.1. (ox.ac.uk)
  • In the present study, the effect of PMPs was investigated on the production of human leukocyte antigen (HLA)-specific antibody from B cells in vitro. (ac.ir)
  • The specificity of the purified HLA-DR antigen was confirmed using the anti-HLA-DR antibody and ELISA technique in the presence of appropriate controls. (ac.ir)
  • Blast cells from peripheral blood of 32 patients with acute leukemia were tested for their ability to react with a monoclonal antibody (D1.B6) specific for HLA-DR surface antigen. (semanticscholar.org)
  • An exuberant production of antibody (especially immunoglobulin G [IgG]) against the offending antigen is frequently identified. (medscape.com)
  • There are currently no images for HLA DR/DP Antibody (NB500-408V). (novusbio.com)
  • The antibody HL-40 reacts with common epitope on beta-chain of human HLA-DR and HLA-DP. (novusbio.com)
  • This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated. (thermofisher.com)
  • The following product was used in this experiment: HLA-DR Monoclonal Antibody (LN3), FITC, eBioscience™ from Thermo Fisher Scientific, catalog # 11-9956-42, RRID AB_2572544. (thermofisher.com)
  • The following antibody was used in this experiment: HLA-DR Monoclonal Antibody (Tü36), Qdot 655 from Thermo Fisher Scientific, catalog # Q22158, RRID AB_2556514. (thermofisher.com)
  • Two-dimensional gel electrophoresis of immunoprecipitated human HLA-DR antigens from cells expressing the HLA-DR4 haplotype shows distinct clustering of beta-chain patterns. (pnas.org)
  • Two cDNA clones, pDRH1 and pDRH2, containing sequences specific for human HLA-DR antigens were isolated from a bank of cDNA clones made from partially purified HLA-DR mRNA from the human lymphoblastoid cell line Maja. (ox.ac.uk)
  • HLA-DR antigens on the intestinal epithelia were identified by the indirect immunoperoxidase staining method using two mouse anti-HLA-DR monoclonal antibodies. (springer.com)
  • Ogasawara K, Kojima H, Ikeda H, et al: A study on class II antigens involved in the T cell proliferative responses to PPD using cross-reacting monoclonal antibodies in human and murine system. (springer.com)
  • Down's syndrome and celiac disease: the prevalence of high IgA-antigliadin antibodies and HLA-DR and DQ antigens in trisomy 21. (nih.gov)
  • Paired specimens were examined by histological and immunohistochemical methods using monoclonal antibodies to the beta chain of HLA-DR antigen. (ox.ac.uk)
  • Antibodies against coxsackievirus B4 were measured to study immune responses induced by natural enterovirus infections and against poliovirus 1 to study immune responses induced by immunisation by enterovirus antigens (vaccine). (cdc.gov)
  • Whereas serological analysis and mixed lymphocyte typing have defined three polymorphic families of Ia antigens, HLA-DR, -DC and -SB, protein sequencing results and studies with monoclonal antibodies indicate that the complexity is much greater. (ox.ac.uk)
  • McHugh, NJ & Maddison, PJ 1989, ' HLA-DR antigens and anticardiolipin antibodies in patients with systemic lupus erythematosus ', Arthritis & Rheumatism , vol. 32, no. 12, pp. 1623-1624. (bath.ac.uk)
  • Because HLA-DR antigens modulate monocyte-T cell interaction, we quantified the proportions of HLA-DR-positive cells in alveolar macrophage and blood monocyte suspensions and determined the inhibitory effects on T-cell proliferation of masking HLA-DR antigens on stimulator cells with monoclonal antibodies. (elsevier.com)
  • Although total immunoglobulin (IgG) was higher in HLA-DR-treated wells, HLA-DR-specific antibodies were not identified by ELISA technique. (ac.ir)
  • However, many patients with precipitating antibodies against antigens associated with hypersensitivity pneumonitis have no disease, suggesting that the precipitating antibodies by themselves are not the cause of the disease. (medscape.com)
  • Antibodies have been used for antigen detection and therapeutics, and their specificity combined with low toxicity make them a promising pharmaceutical commodity [ 1 ]. (mdpi.com)
  • The possible role of HLA-DR antigens in the immunological mechanism in CD is proposed. (springer.com)
  • The role of HLA-DR antigens in the clinicopathological features of autoimmune hepatitis (AIH) is not clearly understood. (biomedcentral.com)
  • In the present study, we thoroughly examined the role of HLA-DR antigens in Japanese AIH, including how HLA-DR4 influences the age of AIH onset and its clinical features. (biomedcentral.com)
  • The authors attempted to investigate the host's immune response against colorectal carcinoma through the expression of HLA-DR antigen on carcinoma cells (Ca) on normal epithelia immediately adjacent to carcinoma (AN) in relation to tumour progression. (mysciencework.com)
  • The expression of HLA-DR antigen on Ca and on normal epithelia, both on AN and those 5-10 cm removed from the carcinoma (RN), were examined immunohistochemically. (mysciencework.com)
  • The expression of HLA-DR antigen on AN was significantly increased compared with RN. (mysciencework.com)
  • Furthermore, the expression of HLA-DR antigen in normal mucosa coincided significantly with the existence of IFN-gamma mRNA. (mysciencework.com)
  • The expression of HLA-DR antigen in mucosal epithelial cells was strongly related to whether the specimens were actively inflamed: epithelial cells from 34 of 37 inflamed specimens (nu three of 42 non-inflamed specimens) were HLA-DR positive (p less than 0.0001). (ox.ac.uk)
  • The expression of HLA-DR antigen is markedly elevated in multiply transfused patients. (annals.org)
  • Fais S, Pallone F, Squarcia O, et al: HLA-DR antigens on colonic epithelial cells in inflammatory bowel disease: I. Relation to the state of activation of lamina propria lymphocytes and to the epithelial expression of other surface markers. (springer.com)
  • Purpose To assess the expression of human leucocyte antigen (HLA)-DR in epithelial cells and cluster of differentiation (CD8)-positive lymphocytes as you possibly can markers of chronic ocular graft versus host disease (cGvHD) after hematological stem cell transplantation (HSCT). (bio-aromatica.com)
  • In this experimental study, HLA-DR antigen was solubilized from the immortalized B lymphocytes (Daudi cell line) and purified using the affinity chromatography. (ac.ir)
  • We anticipate the infusion of HLA-mismatched donor lymphocytes in this setting will produce no detectible engraftment or only temporary engraftment, but may result in a strong GvL effect regardless of engraftment outcome. (clinicaltrials.gov)
  • McDonald GB, Jewell DP: Class II antigen (HLA-DR) expression by intestinal epithelial cells in inflammatory diseases of colon. (springer.com)
  • Darr AS, Fuggle SV, Ting A, et al: Anomolous expression of HLA-DR antigens on human colorectal cancer cells. (springer.com)
  • In this study, we focused on the mycobacteria-driven responses of the NK cells expressing HLA-DR - a type of MHC class II. (frontiersin.org)
  • The expanded HLA-DR + NK cells had less differentiated phenotype, higher proliferative activity and increased expression of NKp30 and NKp46 receptors. (frontiersin.org)
  • HLA-DR + CD56 dim NK cells showed higher IFNγ production and degranulation level than the respective HLA-DR − NK cells in response to both 24 h and 7 day stimulation with sonicate, while HLA-DR + CD56 bright NK cells mostly demonstarted similar high responsiveness to the same stimulating conditions as their HLA-DR − CD56 bright counterparts. (frontiersin.org)
  • After preliminary incubation with destroyed mycobacteria, cytokine-activated HLA-DR-expressing NK cells were able to mediate mycobacteria-induced and HLA-DR-dependent cytokine production in autologous CD4 + T cells. (frontiersin.org)
  • Thus, functionally active HLA-DR + cells seem to be one of the NK cell subsets providing an important link to the adaptive immunity. (frontiersin.org)
  • HLA-DR is also expressed on activated T cells. (cylch.org)
  • Labeling antigen-specific CD4(+) T cells with class II MHC oligomers. (semanticscholar.org)
  • The biological and clinical significance of HLA Class II antigen expression by AML cells is not known. (elsevier.com)
  • HLA-DR antigens were not detected on AML cells from 43 patients, including 20 with acute promyelocytic leukemia (APL), and 23 with other subtypes of AML. (elsevier.com)
  • Interestingly, cells from three HLA-DR-negative non-APL patients had similar morphology to that of the hypogranular variant of APL. (elsevier.com)
  • Epithelial cells in specimens from patients with ulcerative colitis, Crohn's disease, and radiation colitis were HLA-DR positive in 30 of 33 inflamed biopsy specimens and in only three of 25 non-inflamed specimens (p less than 0.0001). (ox.ac.uk)
  • Epithelial cells were HLA-DR positive in nine of 10 biopsy specimens from patients with acute infectious colitis (p less than 0.01). (ox.ac.uk)
  • Colonic epithelial cells from all 21 control subjects with histologically normal colonic mucosa were HLA-DR-. In contrast, in nine of 13 patients with active ulcerative colitis and 11 of 12 with active Crohn's disease the epithelium of involved colonic mucosa was HLA-DR+. (ox.ac.uk)
  • We undertook an immunohistochemical study for the expression of HLA-DR antigens and other immune-related markers by retroperitoneal proliferating fibroblasts and inflammatory cells from 2 IRF patients . (bvsalud.org)
  • However, activation of Th cells and identification of Major Histocompatibility Complex Class II (MHC II) restricted tumor antigens is difficult due to the inhibition of Antigen Presenting Cells (APC) within the tumor environment and the failure of MHC II positive tumors to present endogenous tumor antigens. (arvojournals.org)
  • Our studies in mice demonstrate that in the absence of accessory molecule Invariant Chain (Ii), MHC II positive tumor cells present endogenous antigens, stimulate Th cells, and induce protective anti-tumor immunity. (arvojournals.org)
  • We hypothesize that Ii negative uveal melanoma cells genetically modified to express MHC II and the co-stimulatory molecule CD80 will present endogenous antigens and activate Th cells. (arvojournals.org)
  • As measured by flow cytometry, HLA-DRB*0101 and CD80 transduced uveal melanoma cells express HLA-DR1 and CD80 on the cell surface and do not express Ii. (arvojournals.org)
  • Therefore, HLA-DR + /CD80 + uveal melanoma cells activate Th cells to endogenous antigens, and could be used in uveal melanoma patients to induce tumor-specific CD4 + T cells. (arvojournals.org)
  • HLA-DR + cells have been described in skin at 7 wk EGA. (rupress.org)
  • At 7 wk EGA, some epidermal cells already express HLA-DR, but not CD1a or Lag antigen, a component of Birbeck granules, which appear at ∼12 wk EGA ( 16 , 19 ). (rupress.org)
  • analyzed individual leucocyte antigen (HLA)-DR, which is certainly area of the main histocompatibility organic II and it is involved with antigen display to immune system cells, in conjunctival biopsies and discovered increased appearance after HSCT [5]. (bio-aromatica.com)
  • Therefore, it was our goal to study conjunctival epithelial HLA-DR expression and CD8+ cells in impression cytology specimens of HSCT recipients, to assess if impression cytology might replace conjunctival biopsy in the evaluation of ocular cGVHD. (bio-aromatica.com)
  • B cells were exposed with PMPs and HLA-DR antigens in the culture medium. (ac.ir)
  • Expression of HLA-DR structure and a membrane-specific antigen by a granulocytopoietic line of acute leukemic blast cells]. (semanticscholar.org)
  • The results demonstrated that a considerable proportion of blast cell populations expressed the HLA-DR antigen, while only a small fraction of cells expressed the myeloid antigen. (semanticscholar.org)
  • The presentation of antigen to T cells requires that the antigens first be processed prior to presentation. (springer.com)
  • Assembly and intracellular transport of HLA-DM and correction of the class II antigen-processing defect in T2 cells. (springer.com)
  • High-throughput epitope discovery reveals frequent recognition of neo-antigens by CD4 + T cells in human melanoma. (nature.com)
  • These antigens are polymorphic glycoproteins comprising alpha and beta chains and are found on lymphoid and other cells, often associated with certain diseases. (curehunter.com)
  • Supernatants from antigen-specific-stimulated cells from chronic hypersensitivity pneumonitis produced higher levels of IL-4 and lower levels of IFN-gamma compared with subacute HP. (medscape.com)
  • Cells from the B line WVB coated with mouse antiserum followed by WVB class II antigen. (novusbio.com)
  • The cells do not express B-cell lineage restricted antigens or kappa or lambda immunoglobulin light chains or T-cell lineage-restricted antigens. (atcc.org)
  • The cells do express activation antigens. (atcc.org)
  • Approximately 50% of LS513 cells express surface carcinoembryonic antigen (CEA). (atcc.org)
  • LS513 cells express the major histocompatibility (MHC) class I antigens HLA and beta 2 microglobulin. (atcc.org)
  • The presence of virus was compared with inflammatory markers such as infiltrating T cells, HLA-DR expression, and transglutaminase 2-targeted IgA deposits. (diabetesjournals.org)
  • The role of chronic antigenic stimulation was studied by measurement of HLA-DR expression on T cells. (annals.org)
  • The expression of HLA-DR, IL-6, TNF- α , and TGF- β was higher in monocytes from individuals with moderate to severe fibrosis as compared to other groups. (hindawi.com)
  • The extent of this beta-chain diversity within a single DR haplotype may aid in understanding variations in Ia-regulated functions, such as Ir gene control and certain disease susceptibilities. (pnas.org)
  • HLA-DR antigen and gene frequencies were studied in 150 unrelated Koreans in Seoul . (bvsalud.org)
  • A gene in the human major histocompatibility complex class II region controlling the class I antigen presentation pathway. (springer.com)
  • A gene required for class II restricted antigen presentation maps to the major histocompatibility complex. (springer.com)
  • The HLA-DRB1 gene provides instructions for making a protein that plays a critical role in the immune system. (medlineplus.gov)
  • The HLA complex is the human version of the major histocompatibility complex (MHC), a gene family that occurs in many species. (medlineplus.gov)
  • The protein produced from the HLA-DRB1 gene, called the beta chain, attaches (binds) to another protein called the alpha chain, which is produced from the HLA-DRA gene. (medlineplus.gov)
  • Certain variations in the HLA-DRB1 gene have been linked to an increased risk of developing an autoimmune disorder called autoimmune Addison disease. (medlineplus.gov)
  • A particular HLA-DRB1 gene variant called HLA-DRB1*04:04 is the most well-known risk factor for autoimmune Addison disease. (medlineplus.gov)
  • Variations in the HLA-DRB1 gene have been associated with an increased risk of developing multiple sclerosis. (medlineplus.gov)
  • One variant of this gene, called HLA-DRB1*15:01 , is the most strongly linked genetic factor for the risk of multiple sclerosis. (medlineplus.gov)
  • HLA-DR1 (DR1) is a HLA-DR serotype that recognizes the DRB1*01 gene products. (wikipedia.org)
  • HLA-DR4 (DR4) is an HLA-DR serotype that recognizes the DRB1*04 gene products. (wikipedia.org)
  • Because the HLA-DRB1 gene is involved in the immune system, changes in it might be related to the autoimmune response and inflammation that damage nerves and the protective coating surrounding them (the myelin sheath), leading to the signs and symptoms of multiple sclerosis. (nih.gov)
  • Kudo J., Chao L.Y., Narni F., Saunders G.F. Structure of the human gene encoding the invariant gamma-chain of class II histocompatibility antigens (англ. (wikipedia.org)
  • Interaction of HLA-DR and CD74 at the cell surface of antigen-presenti. (york.ac.uk)
  • We have determined that 25 ± 1.3% of CD74 and 17 ± 0.3% of HLA-DR are colocalized, and the association of CD74 with HLA-DR and the internalization of HLA-DR are both inhibited by HA(307-319). (york.ac.uk)
  • HLA-DR antigens-associated invariant chain ) - мембранный белок , участвующий в функционировании иммунной системы , продукт гена человека CD74 [1] [2] . (wikipedia.org)
  • This suggests that tobacco smoke reduces HLA-DR antigen expression in AM of different maturational states and that this defective expression of HLA class II antigens is not dependent on the amount of phagocytosed autofluorescent tobacco particles. (nih.gov)
  • Antigen targeting to major histocompatibility complex class II with streptococcal mitogenic exotoxin Z-2 M1, a superantigen-based vaccine carrier. (semanticscholar.org)
  • The response of the T cell clones was inhibited differentially by mAbs to DR. Raising TT concentration, or increasing HLA-class II expression with INF-gamma both affected the magnitude of response of the TT-specific clones but did not modify their specificities. (rupress.org)
  • Human anaplastic lymphoma: immunohistochemical staining for HLA class II antigen using NCL-LN3. (leicabiosystems.com)
  • HLA-DR is an MHC Class II antigen that maps to chromosome 6. (leicabiosystems.com)
  • Human leukocyte antigen (HLA) Class II antigens are variably expressed on acute myeloid leukemia (AML) blasts. (elsevier.com)
  • HLA-DQB1 belongs to the HLA class II beta chain paralogs. (cancerindex.org)
  • Accumulation of HLA-DM, a regulator of antigen presentation, in MHC class II compartments. (springer.com)
  • Coordinate defects in human histocompatibility leukocyte antigen class II expression and antigen presentation in bare lymphocyte syndrome. (springer.com)
  • CONCLUSION: Improvement of IBD symptoms during pregnancy is associated with disparity in HLA class II antigens between mother and fetus. (biomedsearch.com)
  • The polymorphisms of HLA class I and II antigens in ESRD patients and a healthy control group were retrospectively analyzed. (biomedcentral.com)
  • In this study, HLA class I and II polymorphisms of ESRD patients were compared to a healthy control group in an effort to provide a better understanding of the etiology of this disease. (biomedcentral.com)
  • MHC class II antigens (HLA-DR, DQ, and DP were not detected). (atcc.org)
  • Three loci, DR, DQ and DP, encode the major expressed products of the human class II region. (thermofisher.com)
  • The frequency of HLA class I and II was determined in a population of patients with spondyloarthritis with respect to detection in the clinical setting and by radiology. (scielo.org.co)
  • Claesson L., Larhammar D., Rask L., Peterson P.A. cDNA clone for the human invariant gamma chain of class II histocompatibility antigens and its implications for the protein structure (англ. (wikipedia.org)
  • Of the two beta polypeptides, only one was invariant in position on NEPHGE/SDS-PAGE analyses of cell lines homozygous for the same DR specificity. (ox.ac.uk)
  • Each mother/child pair was assigned an HLA disparity status (+/-) for HLA A, B, C, DRB1, and DQ loci. (biomedsearch.com)
  • It is not clear how HLA-DRB1*04:04 and other HLA-DRB1 variations are involved in the inappropriate immune response that causes autoimmune Addison disease. (medlineplus.gov)
  • Our findings suggested that birdshot retinochoroidopathy has a genetic predisposition and that retinal autoimmunity, resulting from the S-antigen or other retinal antigens, plays a role in the manifestation of this disease. (nih.gov)
  • These patterns correlate precisely with the HLA-D phenotype of the HCL donor as determined by reactivity in mixed lymphocyte culture. (pnas.org)
  • The HLA-DR phenotype modulates the humoral immune response to enterovirus antigens. (cdc.gov)
  • HLA-DR phenotype distribution was similar regardless of response to immunosuppressive therapy. (biomedcentral.com)
  • We did not detect an influence of the DR phenotype on disease course, age at onset/diagnosis, gender or familiarity. (biomedsearch.com)
  • Analysis of DNA from human, mouse, and human--mouse somatic cell hybrid lines by Southern transfer of restriction endonuclease digests indicated that the HLA-DR heavy chain is encoded in chromosome 6. (ox.ac.uk)
  • The frequency of HLA-B27 was 50% overall, and it was the most frequent allele. (scielo.org.co)
  • Adult human leukocyte antigen (HLA)-matched MSC have been used in cellular therapies of bone disorders such as osteogenesis imperfecta, with promising results. (aber.ac.uk)
  • HLA-D specificities as revealed by T-cell recognition in mixed lymphocyte culture thus might be accounted for by DR beta-chain polymorphisms. (pnas.org)
  • They are involved in the initiation of immune responses and particular Ia antigens are associated with increased susceptibility to certain diseases. (ox.ac.uk)
  • The current work suggests that HLA-DR3 (odds ratio = 1.91, 95 % CI = 1.098-3.324, P = 0.024, Pc = 0.312) and HLA-DR11 (odds ratio = 2.06, 95 % CI = 1.133-3.761, P = 0.021, P c = 0.273) may represent susceptibility risk factors for the development of ESRD in Taiwanese individuals. (biomedcentral.com)
  • Iizuka M, Chiba M, Ohta H, et al: Expression of HLA-DR antigens on colonic epithelium in ulcerative colitis. (springer.com)
  • Selby WS, Janossy G, Mason DY, et al: Expression of HLA-DR antigens by colonic epithelium in inflammatory bowel disease. (springer.com)
  • Expression of HLA-DR antigens by colonic epithelium in inflammatory bowel disease. (ox.ac.uk)
  • The expression of HLA-DR and HLA-A,B,C antigens by human colonic epithelium has been examined in tissue sections of patients with inflammatory bowel disease using an immunohistological technique. (ox.ac.uk)
  • As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. (rcsb.org)
  • Chiba M, Iizuka M, Masamune O: Ubiquitous expression of HLA-DR antigens on human small intestinal epithelium. (springer.com)
  • HLA-DR antigens were found on the epithelium of only one of six patients with ulcerative colitis in remission and one of three with inactive Crohn's disease. (ox.ac.uk)
  • Moreover, these antigens were not present on the epithelium of non-inflamed colonic mucosa in two patients with Crohn's disease in whom adjacent involved mucosa showed strong epithelial reactivity. (ox.ac.uk)
  • PCR-sequence specific primers method was applied to genotype the HLA-DR, DQ polymorphisms that correspond to 17 serologically defined DR and seven DQ antigens. (cdc.gov)
  • CVB1-associated risk was not related to HLA genotype, age, or sex. (diabetesjournals.org)
  • Functional polymorphism of each of the two HLA-DR beta chain loci demonstrated with antigen-specific DR3- and DRw52-restricted T cell clones. (rupress.org)
  • Two polypeptides corresponding in molecular weight to the HLA-DR-associated antigen beta chain were detected. (ox.ac.uk)
  • These findings suggested that the Korean population , while having many similarities in HLA-DR antigen frequencies with those of neighboring Orientals, has not only different features in the distribution of HLA-DR antigens but also has unique HLA-B DR haplotypes . (bvsalud.org)
  • Erratum in: Tissue Antigens 1996 May;47(5):455. (nih.gov)
  • Because an increased incidence of myeloid antigen expression has been observed in Ph + and/or BCR-ABL + ALL, 1 6 10 it has been suggested that cytarabine-based chemotherapy regimens might be associated with high response rates in patients with the disease. (bloodjournal.org)
  • cDNA clones coding for the heavy chain of human HLA-DR antigen. (ox.ac.uk)
  • The clones were specific for the Mr 34,000 HLA-DR antigen glycoprotein chain. (ox.ac.uk)
  • and (iii) a nucleotide sequence in the longer clone, pDRH2, could be translated into an amino acid sequence that is identical to the limited NH2-terminal amino acid sequence available for the purified HLA-DR antigen Mr 34,000 chain. (ox.ac.uk)
  • In addition, the sequences coding for HLA-DR heavy chain appear to be present in only one or a few copies in the genome and to be relatively simple in structure. (ox.ac.uk)
  • The association with HLA-B27 remains one of the strongest known links between these entities and the major histocompatibility complex. (scielo.org.co)
  • Glycoprotein fractions from B lymphoblastoid cell lines homozygous for the DR antigen were used as antigen source. (ox.ac.uk)
  • The alloantigenic determinant(s) defined by the serological HLA-DR3 specificity map to the former, while the supratypic HLA-DRw52 determinants map to DR beta III. (rupress.org)
  • These results demonstrate that a restriction specificity can be attributed to the DR beta III locus and illustrate the functional relevance of the polymorphism observed at this locus. (rupress.org)
  • HLA-DR4 was the most common DR specificity encountered and HLA-DR1 and -DR3 occurred with the lowest frequencies. (bvsalud.org)
  • It appears therefore that the position of one of these beta polypeptides correlates with DR specificity, while the other beta polypeptide exhibits positional variation on NEPHGE/SDS-PAGE analysis, indicative of polymorphism at a second HLA-DR-associated locus. (ox.ac.uk)
  • Together, they form a functional protein complex called the HLA-DR antigen-binding heterodimer. (medlineplus.gov)
  • We have shown earlier that HLA-DR antigens are encoded by two distinct loci, DR beta I and DR beta III. (rupress.org)
  • Conclusions A strong HLA-DR expression as detected by impression cytology appears to indicate an over-all HSCT response and does not anticipate ocular cGVHD. (bio-aromatica.com)
  • Detection in carcinoma tissues of IFN-gamma mRNA that leads to the induction of HLA-DR antigen on AN could be an indicator of a host's immune response to carcinoma. (mysciencework.com)
  • Of the 20 patients, 13 were also tested for evidence of an in vitro mitotic immune response to purified retinal S-antigen. (nih.gov)
  • This suggests that the maternal immune response to paternal HLA antigens plays a role in pregnancy-induced remission. (biomedsearch.com)
  • A major issue with Schistosoma mansoni infection is the development of periportal fibrosis, which is predominantly caused by the host immune response to egg antigens. (hindawi.com)
  • The liver pathology of Schistosoma mansoni infection results from the host immune response to parasite antigens from S. mansoni eggs that become trapped in the portal venous system [ 5 - 7 ]. (hindawi.com)
  • Human Ia antigens are polymorphic cell-surface sialoglycoproteins which have restricted tissue distribution. (ox.ac.uk)
  • The frequency of HLA-DR3 was significantly increased in the patients as compared with the controls (78.4% versus 25.7%, corrected P = 1.68 x 10 -12 ), the relative risk (RR) of 10.52 being much higher than that reported in the Western IDDM population. (elsevier.com)
  • HLA-DR4 was the only DR antigen significantly associated with Japanese AIH. (biomedcentral.com)
  • CsA CE also significantly reduced median HLA-DR expression versus vehicle at 6 months (P=0.002). (bmj.com)
  • Taming the TCR: antigen-specific immunotherapeutic agents for autoimmune diseases. (semanticscholar.org)
  • Human leukocyte antigens (HLA) have been found to be associated with the pathogenesis of autoimmune diseases, allergies and inflammatory bowel diseases, and there are emerging evidences of correlations between HLA genotypes and renal diseases such as diabetic nephropathy, IgA nephropathy, and glomerulonephritis. (biomedcentral.com)
  • Horie Y, Chiba M, Iizuka M, et al: Colonie lymphoid cell subsets and epithelial HLA-DR antigens in familial polyposis coli. (springer.com)
  • Six unique electrophoretic variants were observed among 17 HLA-DR4 homozygous cell lines (HCL) analyzed. (pnas.org)
  • AM of smokers were more heterogeneous in respect to cell size, autofluorescence, and HLA-DR antigen expression. (nih.gov)
  • HLA-DR antigen density on AM of smokers was independent of cell size and autofluorescence. (nih.gov)
  • HLA-DR3- and HLA-DRw52-associated functional polymorphism was investigated with selected tetanus toxoid (TT)-specific T cell clones. (rupress.org)
  • Among the selected T cell clones, 5 reacted exclusively when TT was presented by HLA-DR3+ APCs (TT-DR3-APC). (rupress.org)
  • Suppression of lymphoblastoid cell line proliferation by antisera to HLA-DR and other HLA antigens. (wizdom.ai)
  • Fig. 6: MARIA scores predict melanoma HLA-II-presented antigens and are associated with post-vaccine CD4 + T cell responses. (nature.com)
  • The versatility of the αβ T-cell antigen receptor. (ebi.ac.uk)
  • Cell-free synthesis and processing of the heavy and light chains of HLA-DR antigens. (wikigenes.org)
  • In this study, we propose to use a novel strategy to treat leukemias relapsing after HLA matched allogeneic stem cell transplantation by using haplo-identical DLIs to promote the associated antileukemic effect while minimizing the possibility of permanent engraftment and associated GvHD. (clinicaltrials.gov)
  • Several small studies, using serological typing, have reported that HLA-DR11, DR12, and DQ7 were increased in LS, with DR17 less frequent. (cdc.gov)
  • Fig. 5: MARIA identifies lymphoma immunoglobulin HLA-DR presentation hotspots in patients with MCL. (nature.com)
  • Antigen presentation profiling reveals recognition of lymphoma immunoglobulin neoantigens. (nature.com)
  • HLA-DR and -DQ antigens were also determined in 75 DS patients (20 with high and 55 with normal IgA-AGA levels), and the percentages of the different phenotypes were compared in the two groups and with those of a control group. (nih.gov)
  • This is a retrospective analysis of the results of HLA AB and DR antigen matching in 56 transfused cadaver transplant patients. (mdedge.com)
  • Patients with tumours showing HLA-DR staining both in Ca and AN were in less advanced Dukes' stages (Dukes' A or B) compared with those without the stain. (mysciencework.com)
  • Treatment response was similar in the 23 HLA-DR-negative non-APL and the 205 HLA-DR-positive patients. (elsevier.com)
  • Antigen HLA-A29 was present in 16 of 20 patients (80%) with birdshot retinochoroidopathy, but only in 31 of 418 controls (7.4%) (P less than .0001). (nih.gov)
  • Eighty-eight North Indian patients with type I, insulin-dependent diabetes mellitus (IDDM) and 113 unaffected individuals were typed for HLA-DR antigens from DR1 to DR7. (elsevier.com)
  • AIH patients were divided into HLA-DR4-positive or HLA-DR4-negative groups and further sub-classified into elderly and young-to-middle-aged groups, and differences in clinical and histological features were examined. (biomedcentral.com)
  • HLA-DR4-positive AIH patients were younger than HLA-DR4-negative patients ( P = 0.034). (biomedcentral.com)
  • 0.001 and P = 0.007, respectively) in HLA-DR4-positive patients. (biomedcentral.com)
  • However, there was no difference in IgG and IgM levels between HLA-DR4-positive and HLA-DR4-negative patients of the young-to-middle-aged group. (biomedcentral.com)
  • The clinical features of HLA-DR4-positive AIH differed between elderly patients and young-to-middle-aged patients. (biomedcentral.com)
  • In Japan, HLA-DR4 is frequently found in AIH patients, as has been shown in European or North American Caucasoid patients. (biomedcentral.com)
  • In a report on North American patients, the clinical features of HLA-DR4-positive AIH differed from those of HLA-DR4-negative patients [ 11 ]. (biomedcentral.com)
  • A total of 132 patients who had been consecutively diagnosed with AIH, treated, and examined for the HLA-DR antigen at Tokyo Metropolitan Bokutoh Hospital and the Jikei University School of Medicine Katsushika Medical Center (2 of the major hepatology centers in eastern Tokyo district) from the beginning of 2000 till May 2014 were the subjects of this study. (biomedcentral.com)
  • The information of 141 ESRD patients was obtained from the medical record of the Keelung branch of Chang Gung Memorial Hospital and was compared to the HLA type of a control group comprized of 190 healthy unrelated Taiwanese from one of our previous studies. (biomedcentral.com)
  • HLA typing might be a useful clinical method for screening patients with high risk of progression to ESRD. (biomedcentral.com)
  • A high frequency of HLA-B27 and HLA-DRB4*01 (64.3%) was noted in patients with dactylitis. (scielo.org.co)
  • These results show that chronic exposure to foreign antigens may be associated with abnormalities of immunologic function, but that chronically transfused patients do not have the same immunologic profile as reported in some homosexuals and hemophiliacs. (annals.org)
  • HLA-DR-dependent, MHC-restricted antigen-presentation and IL-1 alpha expression. (jimmunol.org)
  • In lyme disease arthritis, *0101 appears to play a role in presentation of triggering microbial antigens. (wikipedia.org)
  • The polypeptide composition of HLA-DR-associated antigens was analyzed by two-dimensional nonequilibrium pH gradient electrophoresis (NEPHGE)/sodium dodecyl sulfate (SDS)-polyacrylamide gel electrophoresis (PAGE). (ox.ac.uk)
  • Fig. 3: Benchmarking MARIA performance against existing binding-based methods with independent HLA-DR test sets. (nature.com)
  • A group of the D-related HLA antigens (human) found to differ from the DR antigens in genetic locus and therefore inheritance. (curehunter.com)