A group of the D-related HLA antigens found to differ from the DR antigens in genetic locus and therefore inheritance. These antigens are polymorphic glycoproteins comprising alpha and beta chains and are found on lymphoid and other cells, often associated with certain diseases.
Antigens determined by leukocyte loci found on chromosome 6, the major histocompatibility loci in humans. They are polypeptides or glycoproteins found on most nucleated cells and platelets, determine tissue types for transplantation, and are associated with certain diseases.
A malabsorption syndrome that is precipitated by the ingestion of foods containing GLUTEN, such as wheat, rye, and barley. It is characterized by INFLAMMATION of the SMALL INTESTINE, loss of MICROVILLI structure, failed INTESTINAL ABSORPTION, and MALNUTRITION.
A subclass of HLA-D antigens that consist of alpha and beta chains. The inheritance of HLA-DR antigens differs from that of the HLA-DQ ANTIGENS and HLA-DP ANTIGENS.
Substances that are recognized by the immune system and induce an immune reaction.
Substances elaborated by bacteria that have antigenic activity.
Proteins, glycoprotein, or lipoprotein moieties on surfaces of tumor cells that are usually identified by monoclonal antibodies. Many of these are of either embryonic or viral origin.
Antigens on surfaces of cells, including infectious or foreign cells or viruses. They are usually protein-containing groups on cell membranes or walls and may be isolated.
Substances elaborated by viruses that have antigenic activity.
Any part or derivative of any protozoan that elicits immunity; malaria (Plasmodium) and trypanosome antigens are presently the most frequently encountered.
Polyomavirus antigens which cause infection and cellular transformation. The large T antigen is necessary for the initiation of viral DNA synthesis, repression of transcription of the early region and is responsible in conjunction with the middle T antigen for the transformation of primary cells. Small T antigen is necessary for the completion of the productive infection cycle.
Large, transmembrane, non-covalently linked glycoproteins (alpha and beta). Both chains can be polymorphic although there is more structural variation in the beta chains. The class II antigens in humans are called HLA-D ANTIGENS and are coded by a gene on chromosome 6. In mice, two genes named IA and IE on chromosome 17 code for the H-2 antigens. The antigens are found on B-lymphocytes, macrophages, epidermal cells, and sperm and are thought to mediate the competence of and cellular cooperation in the immune response. The term IA antigens used to refer only to the proteins encoded by the IA genes in the mouse, but is now used as a generic term for any class II histocompatibility antigen.
Differentiation antigens residing on mammalian leukocytes. CD stands for cluster of differentiation, which refers to groups of monoclonal antibodies that show similar reactivity with certain subpopulations of antigens of a particular lineage or differentiation stage. The subpopulations of antigens are also known by the same CD designation.
Substances of fungal origin that have antigenic activity.
Human immune-response or Class II antigens found mainly, but not exclusively, on B-lymphocytes and produced from genes of the HLA-D locus. They are extremely polymorphic families of glycopeptides, each consisting of two chains, alpha and beta. This group of antigens includes the -DR, -DQ and -DP designations, of which HLA-DR is most studied; some of these glycoproteins are associated with certain diseases, possibly of immune etiology.
Class I human histocompatibility (HLA) surface antigens encoded by more than 30 detectable alleles on locus B of the HLA complex, the most polymorphic of all the HLA specificities. Several of these antigens (e.g., HLA-B27, -B7, -B8) are strongly associated with predisposition to rheumatoid and other autoimmune disorders. Like other class I HLA determinants, they are involved in the cellular immune reactivity of cytolytic T lymphocytes.
The major group of transplantation antigens in the mouse.
Polymorphic class I human histocompatibility (HLA) surface antigens present on almost all nucleated cells. At least 20 antigens have been identified which are encoded by the A locus of multiple alleles on chromosome 6. They serve as targets for T-cell cytolytic responses and are involved with acceptance or rejection of tissue/organ grafts.
Any part or derivative of a helminth that elicits an immune reaction. The most commonly seen helminth antigens are those of the schistosomes.
Membrane glycoproteins consisting of an alpha subunit and a BETA 2-MICROGLOBULIN beta subunit. In humans, highly polymorphic genes on CHROMOSOME 6 encode the alpha subunits of class I antigens and play an important role in determining the serological specificity of the surface antigen. Class I antigens are found on most nucleated cells and are generally detected by their reactivity with alloantisera. These antigens are recognized during GRAFT REJECTION and restrict cell-mediated lysis of virus-infected cells.
A glycoprotein that is secreted into the luminal surface of the epithelia in the gastrointestinal tract. It is found in the feces and pancreaticobiliary secretions and is used to monitor the response to colon cancer treatment.
Sites on an antigen that interact with specific antibodies.
Those proteins recognized by antibodies from serum of animals bearing tumors induced by viruses; these proteins are presumably coded for by the nucleic acids of the same viruses that caused the neoplastic transformation.
Antibodies produced by a single clone of cells.
An HLA-DR antigen which is associated with HLA-DRB1 CHAINS encoded by DRB1*03 alleles.
A group of antigens that includes both the major and minor histocompatibility antigens. The former are genetically determined by the major histocompatibility complex. They determine tissue type for transplantation and cause allograft rejections. The latter are systems of allelic alloantigens that can cause weak transplant rejection.
Molecules on the surface of T-lymphocytes that recognize and combine with antigens. The receptors are non-covalently associated with a complex of several polypeptides collectively called CD3 antigens (ANTIGENS, CD3). Recognition of foreign antigen and the major histocompatibility complex is accomplished by a single heterodimeric antigen-receptor structure, composed of either alpha-beta (RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA) or gamma-delta (RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA) chains.
A specific HLA-A surface antigen subtype. Members of this subtype contain alpha chains that are encoded by the HLA-A*02 allele family.
Identification of the major histocompatibility antigens of transplant DONORS and potential recipients, usually by serological tests. Donor and recipient pairs should be of identical ABO blood group, and in addition should be matched as closely as possible for HISTOCOMPATIBILITY ANTIGENS in order to minimize the likelihood of allograft rejection. (King, Dictionary of Genetics, 4th ed)
Transmembrane proteins that form the beta subunits of the HLA-DQ antigens.
Lymphocytes responsible for cell-mediated immunity. Two types have been identified - cytotoxic (T-LYMPHOCYTES, CYTOTOXIC) and helper T-lymphocytes (T-LYMPHOCYTES, HELPER-INDUCER). They are formed when lymphocytes circulate through the THYMUS GLAND and differentiate to thymocytes. When exposed to an antigen, they divide rapidly and produce large numbers of new T cells sensitized to that antigen.
Nuclear antigen with a role in DNA synthesis, DNA repair, and cell cycle progression. PCNA is required for the coordinated synthesis of both leading and lagging strands at the replication fork during DNA replication. PCNA expression correlates with the proliferation activity of several malignant and non-malignant cell types.
IMMUNOGLOBULINS on the surface of B-LYMPHOCYTES. Their MESSENGER RNA contains an EXON with a membrane spanning sequence, producing immunoglobulins in the form of type I transmembrane proteins as opposed to secreted immunoglobulins (ANTIBODIES) which do not contain the membrane spanning segment.
A glycoprotein that is a kallikrein-like serine proteinase and an esterase, produced by epithelial cells of both normal and malignant prostate tissue. It is an important marker for the diagnosis of prostate cancer.
The lipopolysaccharide-protein somatic antigens, usually from gram-negative bacteria, important in the serological classification of enteric bacilli. The O-specific chains determine the specificity of the O antigens of a given serotype. O antigens are the immunodominant part of the lipopolysaccharide molecule in the intact bacterial cell. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
An HLA-DR antigen which is associated with HLA-DRB1 CHAINS encoded by DRB1*04 alleles.
Differentiation antigens found on thymocytes and on cytotoxic and suppressor T-lymphocytes. CD8 antigens are members of the immunoglobulin supergene family and are associative recognition elements in MHC (Major Histocompatibility Complex) Class I-restricted interactions.
A trisaccharide antigen expressed on glycolipids and many cell-surface glycoproteins. In the blood the antigen is found on the surface of NEUTROPHILS; EOSINOPHILS; and MONOCYTES. In addition, CD15 antigen is a stage-specific embryonic antigen.
An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.
Carbohydrate antigens expressed by malignant tissue. They are useful as tumor markers and are measured in the serum by means of a radioimmunoassay employing monoclonal antibodies.
A subtype of HLA-DRB beta chains that includes over one hundred allele variants. The HLA-DRB1 subtype is associated with several of the HLA-DR SEROLOGICAL SUBTYPES.
Serological reactions in which an antiserum against one antigen reacts with a non-identical but closely related antigen.
The major immunoglobulin isotype class in normal human serum. There are several isotype subclasses of IgG, for example, IgG1, IgG2A, and IgG2B.
Morphologic alteration of small B LYMPHOCYTES or T LYMPHOCYTES in culture into large blast-like cells able to synthesize DNA and RNA and to divide mitotically. It is induced by INTERLEUKINS; MITOGENS such as PHYTOHEMAGGLUTININS, and by specific ANTIGENS. It may also occur in vivo as in GRAFT REJECTION.
A group of the D-related HLA antigens (human) found to differ from the DR antigens in genetic locus and therefore inheritance. These antigens are polymorphic glycoproteins comprising alpha and beta chains and are found on lymphoid and other cells, often associated with certain diseases.
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
Genetic loci in the vertebrate major histocompatibility complex that encode polymorphic products which control the immune response to specific antigens. The genes are found in the HLA-D region in humans and in the I region in mice.
Complex of at least five membrane-bound polypeptides in mature T-lymphocytes that are non-covalently associated with one another and with the T-cell receptor (RECEPTORS, ANTIGEN, T-CELL). The CD3 complex includes the gamma, delta, epsilon, zeta, and eta chains (subunits). When antigen binds to the T-cell receptor, the CD3 complex transduces the activating signals to the cytoplasm of the T-cell. The CD3 gamma and delta chains (subunits) are separate from and not related to the gamma/delta chains of the T-cell receptor (RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA).
Class I human histocompatibility (HLA) antigens encoded by a small cluster of structural genes at the C locus on chromosome 6. They have significantly lower immunogenicity than the HLA-A and -B determinants and are therefore of minor importance in donor/recipient crossmatching. Their primary role is their high-risk association with certain disease manifestations (e.g., spondylarthritis, psoriasis, multiple myeloma).
Those hepatitis B antigens found on the surface of the Dane particle and on the 20 nm spherical and tubular particles. Several subspecificities of the surface antigen are known. These were formerly called the Australia antigen.
Sets of cell surface antigens located on BLOOD CELLS. They are usually membrane GLYCOPROTEINS or GLYCOLIPIDS that are antigenically distinguished by their carbohydrate moieties.
Transmembrane proteins that form the alpha subunits of the HLA-DQ antigens.
The property of antibodies which enables them to react with some ANTIGENIC DETERMINANTS and not with others. Specificity is dependent on chemical composition, physical forces, and molecular structure at the binding site.
Variant forms of the same gene, occupying the same locus on homologous CHROMOSOMES, and governing the variants in production of the same gene product.
Established cell cultures that have the potential to propagate indefinitely.
55-kDa antigens found on HELPER-INDUCER T-LYMPHOCYTES and on a variety of other immune cell types. CD4 antigens are members of the immunoglobulin supergene family and are implicated as associative recognition elements in MAJOR HISTOCOMPATIBILITY COMPLEX class II-restricted immune responses. On T-lymphocytes they define the helper/inducer subset. CD4 antigens also serve as INTERLEUKIN-15 receptors and bind to the HIV receptors, binding directly to the HIV ENVELOPE PROTEIN GP120.
Lymphoid cells concerned with humoral immunity. They are short-lived cells resembling bursa-derived lymphocytes of birds in their production of immunoglobulin upon appropriate stimulation.
Test for tissue antigen using either a direct method, by conjugation of antibody with fluorescent dye (FLUORESCENT ANTIBODY TECHNIQUE, DIRECT) or an indirect method, by formation of antigen-antibody complex which is then labeled with fluorescein-conjugated anti-immunoglobulin antibody (FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT). The tissue is then examined by fluorescence microscopy.
High-molecular weight glycoproteins uniquely expressed on the surface of LEUKOCYTES and their hemopoietic progenitors. They contain a cytoplasmic protein tyrosine phosphatase activity which plays a role in intracellular signaling from the CELL SURFACE RECEPTORS. The CD45 antigens occur as multiple isoforms that result from alternative mRNA splicing and differential usage of three exons.
The genetic region which contains the loci of genes which determine the structure of the serologically defined (SD) and lymphocyte-defined (LD) TRANSPLANTATION ANTIGENS, genes which control the structure of the IMMUNE RESPONSE-ASSOCIATED ANTIGENS, HUMAN; the IMMUNE RESPONSE GENES which control the ability of an animal to respond immunologically to antigenic stimuli, and genes which determine the structure and/or level of the first four components of complement.
Molecules on the surface of B- and T-lymphocytes that recognize and combine with specific antigens.
Antigens of the virion of the HEPATITIS B VIRUS or the Dane particle, its surface (HEPATITIS B SURFACE ANTIGENS), core (HEPATITIS B CORE ANTIGENS), and other associated antigens, including the HEPATITIS B E ANTIGENS.
The processes triggered by interactions of ANTIBODIES with their ANTIGENS.
Immunized T-lymphocytes which can directly destroy appropriate target cells. These cytotoxic lymphocytes may be generated in vitro in mixed lymphocyte cultures (MLC), in vivo during a graft-versus-host (GVH) reaction, or after immunization with an allograft, tumor cell or virally transformed or chemically modified target cell. The lytic phenomenon is sometimes referred to as cell-mediated lympholysis (CML). These CD8-positive cells are distinct from NATURAL KILLER CELLS and NATURAL KILLER T-CELLS. There are two effector phenotypes: TC1 and TC2.
Deliberate stimulation of the host's immune response. ACTIVE IMMUNIZATION involves administration of ANTIGENS or IMMUNOLOGIC ADJUVANTS. PASSIVE IMMUNIZATION involves administration of IMMUNE SERA or LYMPHOCYTES or their extracts (e.g., transfer factor, immune RNA) or transplantation of immunocompetent cell producing tissue (thymus or bone marrow).
The production of ANTIBODIES by proliferating and differentiated B-LYMPHOCYTES under stimulation by ANTIGENS.
Glycoproteins expressed on cortical thymocytes and on some dendritic cells and B-cells. Their structure is similar to that of MHC Class I and their function has been postulated as similar also. CD1 antigens are highly specific markers for human LANGERHANS CELLS.
Antigens expressed primarily on the membranes of living cells during sequential stages of maturation and differentiation. As immunologic markers they have high organ and tissue specificity and are useful as probes in studies of normal cell development as well as neoplastic transformation.
A specific HLA-B surface antigen subtype. Members of this subtype contain alpha chains that are encoded by the HLA-B*08 allele family.
Serum that contains antibodies. It is obtained from an animal that has been immunized either by ANTIGEN injection or infection with microorganisms containing the antigen.
Immunoglobulins produced in a response to BACTERIAL ANTIGENS.
A specific HLA-B surface antigen subtype. Members of this subtype contain alpha chains that are encoded by the HLA-B*07 allele family.
A specific HLA-B surface antigen subtype. Members of this subtype contain alpha chains that are encoded by the HLA-B*27 allele family.
Genetic loci in the vertebrate major histocompatibility complex which encode polymorphic characteristics not related to immune responsiveness or complement activity, e.g., B loci (chicken), DLA (dog), GPLA (guinea pig), H-2 (mouse), RT-1 (rat), HLA-A, -B, and -C class I genes of man.
Endogenous tissue constituents that have the ability to interact with AUTOANTIBODIES and cause an immune response.
Antigens associated with specific proteins of the human adult T-cell immunodeficiency virus (HIV); also called HTLV-III-associated and lymphadenopathy-associated virus (LAV) antigens.

Class II HLA alleles and hepatitis B virus persistence in African Americans. (1/1046)

Persistence of hepatitis B virus (HBV) infection is likely due to the interplay of the virus and host immune response. Given its critical role in antigen presentation, allelic differences in the HLA complex may affect HBV persistence. In a prospectively followed African American cohort, molecular class I and class II HLA typing was done on 31 subjects with persistent HBV infection and 60 controls who cleared the infection. HBV persistence was significantly associated with two class II alleles, DQA1 *0501 (odds ratio [OR], 2.6; P=.05) and DQB1 *0301 (OR, 3.9; P=.01), the two-locus haplotype consisting of these same two alleles (OR, 3; P=. 005) and the three-locus haplotype, DQA1 *0501, DQB1 *0301, and DRB1 *1102 (OR, 10.7; P=.01). In addition, HBV persistence was associated with class II allelic homozygosity. Several class I associations with persistence were also noted but were not statistically significant after correction for multiple comparisons. These results underscore the importance of the class II-mediated immune response in recovery from HBV infection.  (+info)

MHC class II gene associations with autoantibodies to U1A and SmD1 proteins. (2/1046)

Autoantibodies against U small nuclear ribonucleoproteins (snRNP) are frequently present in the serum of patients with systemic rheumatic diseases, and have been reported to be associated with HLA-DR and -DQ genes. To better define the role of HLA genes in the production of such antibodies, we studied immunogenetic associations with autoantibodies reacting with U1 RNP, U1A and SmD1 proteins, and synthetic peptides containing immunodominant linear epitopes of these proteins. Only two out of the 15 overlapping peptides of U1A (i.e. peptides 35-58 and 257-282) and three of 11 peptides of SmD1 (i.e. peptides 1-20, 44-67 and 97-119) were significantly recognized by patients' sera selected on the basis of their antibody positivity with RNP in immunodiffusion. The distribution of DRB1, DQB1 and DPB1 alleles among the anti-RNP antibody-positive patients (n = 28) and healthy control subjects was similar. Antibodies against U1A (tested in Western immunoblotting with HeLa cell extracts) were positively associated to DRB1*06 allele; antibodies reacting with SmD1 peptide 44-67 were negatively associated to DRB1*02 and DQB1*0602 alleles. No association was found between DPB1 alleles and antibodies reacting with U1A and SmD1 antigens. This first study reporting an association between autoantibodies reacting with U1A and SmD1 proteins (and peptides of these proteins), and immunogenetic markers suggest that the production of antibody subsets directed against different components (or regions of these proteins) bound to the same snRNP particle is associated with distinct MHC class II alleles.  (+info)

Immune responses against human papillomavirus (HPV) type 16 virus-like particles in a cohort study of women with cervical intraepithelial neoplasia. I. Differential T-helper and IgG responses in relation to HPV infection and disease outcome. (3/1046)

T-helper (Th) cell-dependent IL-2 production and plasma IgG responses to virus-like particles consisting of the human papillomavirus type 16 (HPV-16) major capsid protein L1 (L1-VLP) were determined in patients with cytological evidence of cervical intraepithelial neoplasia (CIN) participating in a non-intervention prospective cohort study. IgG responses were associated with HPV-16 persistence and high-grade CIN lesions, while high frequencies of Th responses were observed in patients with both virus clearance and virus persistence, irrespective of CIN grade. The IgG response was found in conjunction with an IL-2 response to L1-VLP in 87% of the patients. Recognition of the HPV-16 L1 Th epitope (amino acids 311-335) was found to be more closely associated than recognition of L1-VLP as a whole to HPV exposure and CIN development. Among the HPV-16+ patients included in this study, those showing a Th response to amino acids 311-335 were more likely to carry the HLA DRB1*11/DQB1*0301 haplotype, while those showing an IgG response to L1-VLP were more likely to carry DRB1*0101/DQB1*0501. However, neither cell-mediated nor humoral immune responses against HPV-16 L1 appear to be sufficient for the natural control of HPV infection and CIN development.  (+info)

Major DQ8-restricted T-cell epitopes for human GAD65 mapped using human CD4, DQA1*0301, DQB1*0302 transgenic IA(null) NOD mice. (4/1046)

The 65KD isoform of GAD is considered to be a major target autoantigen in many humans with autoimmune prediabetes or diabetes. The major histocompatibility complex class II allele DQA1*0301, DQB1*0302, which encodes HLA-DQ8, confers susceptibility to type 1 diabetes and occurs in up to 80% of affected individuals. To map T-cell epitopes for GAD65 restricted to the diabetes-associated DQ8 heterodimer, we generated transgenic NOD mice expressing HLA-DQ8 and human CD4 while having the mouse class II gene (IA(beta)) deleted. These mice were immunized with full-length purified recombinant GAD65, and the fine specificity of T-cell responses was mapped by examining recall responses of bulk splenocytes to an overlapping set of 20-mer peptides encompassing the entire GAD65 protein. Four different peptides (P121-140, P201-220, P231-250, and P471-490) gave significant T-cell recall responses. P201-220 and P231-250 have been shown previously to bind DQ8, whereas the other two peptides had been classified as nonbinders. Interestingly, the peptide giving the greatest response (P201-220) encompasses residues 206-220 of GAD65, a region that has been shown to be a dominant T-cell epitope in wild-type IA(g7) NOD mice. Overlap in this T-cell epitope likely reflects structural similarities between DQ8 and IA(g7). The fine specificity of antibody responses in the GAD65-immunized mice was also examined by testing the antisera by enzyme-linked immunosorbent assay (ELISA) against the same overlapping set of peptides. The two dominant B-cell epitopes were P361-380 and P381-400; P121-140 and P471-490 appeared to correspond to both B- and T-cell epitopes. Although the NOD human CD4, DQ8, IA(null) transgenic mice generated in these studies do not develop autoimmune diabetes either spontaneously or after cyclophosphamide treatment, they can be used to map DQ8-restricted T-cell epitopes for a variety of human islet autoantigens. They can also be used to test T-cell-specific reagents, such as fluorescently labeled DQ8 tetramers containing GAD65 peptides or other beta-cell peptides, which we believe will be useful in analyzing human immune responses in diabetic and prediabetic patients.  (+info)

Inhibition of allorecognition by a human class II MHC-derived peptide through the induction of apoptosis. (5/1046)

The interaction of the T-cell receptor with the major histocomatibility complex (MHC)-peptide complex is central to T-cell activation. Variation in the nature of the peptide bound within the groove of the MHC molecule may result in an altered T-cell response. Because some naturally processed peptides bound within the groove of the class II MHC molecule are derived from the MHC molecules themselves, we studied the inhibitory effects of synthetic class II MHC peptides on alloimmune responses in vitro. Three peptides derived from a highly conserved region of the class II MHC alpha chains inhibited the rat mixed lymphocyte response (MLR) in a dose-dependent manner, with the human HLA-DQA1 peptide also inhibiting the human and mouse MLR. No effect was seen on mitogen-induced T-cell proliferation. HLA-DQA1 inhibited cytolytic T lymphocyte (CTL) generation in a dose-response fashion, with no reduction in preformed CTL killing, suggesting that the inhibitory effect is targeted at CD4(+) T-cell function. Cell-cycle analysis by flow cytometry showed that restimulation of primed T cells in the presence of HLA-DQA1 resulted in increased apoptosis, whereas unstimulated cells were not affected. These data demonstrate that synthetic peptides derived from highly conserved regions of the class II MHC alpha chain can alter CD4(+) T-lymphocyte alloimmune responses in vitro, and this effect is mediated by the induction of apoptosis in activated T cells.  (+info)

Influence of ethnic background on clinical and serologic features in patients with systemic sclerosis and anti-DNA topoisomerase I antibody. (6/1046)

OBJECTIVE: To investigate the effect of ethnicity on clinical and serologic expression in patients with systemic sclerosis (SSc) and anti-DNA topoisomerase I (anti-topo I) antibody. METHODS: Clinical and serologic features, as well as HLA class II allele frequencies, were compared among 47 North American white, 15 North American black, 43 Japanese, and 12 Choctaw Native American SSc patients with anti-topo I antibody. RESULTS: The frequency of progressive pulmonary interstitial fibrosis was lower, and cumulative survival rates were better in white compared with black and Japanese patients. Sera of white and black patients frequently recognized the portion adjacent to the carboxyl terminus of topo I, sera of Japanese patients preferentially recognized the portion adjacent to the amino terminus of topo I, and sera of Choctaw patients recognized both portions of topo I. Anti-RNA polymerase II and anti-SSA/Ro antibodies were present together with anti-topo I antibody more frequently in sera of Japanese patients than in sera of white patients. The HLA-DRB1 alleles associated with anti-topo I antibody differed; i.e., DRB1*1101-*1104 in whites and blacks, DRB1*1502 in Japanese, and DRB1*1602 in Choctaws. Multivariate analysis showed that ethnic background was an independent determinant affecting development of severe lung disease as well as survival. CONCLUSION: Clinical and serologic features in SSc patients were strongly influenced by ethnic background. The variability of disease expression in the 4 ethnic groups suggests that multiple factors linked to ethnicity, including genetic and environmental factors, modulate clinical manifestations, disease course, and autoantibody status in SSc.  (+info)

Analysis of MHC class II DP, DQ and DR alleles in Crohn's disease. (7/1046)

BACKGROUND: Although inflammation in Crohn's disease is believed to be mediated by activated T cells, genotyping of all MHC class II alleles in white people with this disease has not been reported. AIMS: To perform a detailed molecular analysis of HLA DPB, DQB, and DRB genes in white patients with Crohn's disease and controls in order to determine if the inheritance of any class II genes confers susceptibility or resistance to this disease. METHODS: Complete molecular typing of HLA class II DPB, DQB, and DRB alleles was performed in 58 white patients with Crohn's disease and 93 healthy controls using a polymerase chain reaction-sequence specific oligonucleotide based approach. RESULTS: No significant association with any DPB or DQB alleles was noted in patients with Crohn's disease. Since our previous studies had shown a strong association of an HLA DRB3*0301/DRB1*1302 haplotype with Crohn's disease, we re-examined this association using more stringent genotyping criteria. This haplotype was present in 20.7% of patients and 5.4% of controls (p = 0.0066; relative risk = 4.59). CONCLUSIONS: The DRB3*0301/DRB1*1302 haplotype is the only significant MHC class II association noted in white people with Crohn's disease and represents the strongest association of any MHC or non-MHC locus with this disease.  (+info)

Generation of humanized mice susceptible to peptide-induced inflammatory heart disease. (8/1046)

BACKGROUND: Dilated cardiomyopathy (DCM) is a major cause of sudden cardiac death. In certain mouse major histocompatibility complex (MHC) backgrounds, myocarditis and inflammatory cardiomyopathy can be triggered by immunization with heart muscle-specific proteins. Similarly, chronic heart disease in humans has been linked to certain HLA alleles, such as HLA-DQ6. However, there is no experimental evidence showing that human MHC class II molecules and peptides derived from human proteins are involved in the pathogenesis of myocarditis and DCM. METHODS AND RESULTS: We generated double CD4- and CD8-deficient mice transgenic for human CD4 (hCD4) and human HLA-DQ6 to specifically reconstitute the human CD4/DQ6 arm of the immune system in mice. Transgenic hCD4 and HLA-DQ6 expression rendered genetically resistant C57BL/6 mice susceptible to the induction of autoimmune myocarditis induced by immunization with cardiac myosin. Moreover, we identified heart-specific peptides derived from both mouse and human alpha-myosin heavy chains capable of inducing inflammatory heart disease in hCD4 and HLA-DQ6 double transgenic mice but not in hCD4 single transgenic littermates. The autoimmune inflammatory heart disease induced by the human heart muscle-specific peptide in hCD4 and HLA-DQ6 double transgenic mice shared functional and phenotypic features with the disease occurring in disease-susceptible nontransgenic mice. CONCLUSIONS: Our data provide the first genetic and functional evidence that human MHC class II molecules and a human alpha-myosin heavy chain-derived peptide can cause inflammatory heart disease and suggest that human inflammatory cardiomyopathy can be caused by organ-specific autoimmunity. The humanized mice generated in this study will be an ideal animal model to further elucidate the pathogenesis of inflammatory heart disease and facilitate the development of rational treatment strategies.  (+info)

TY - JOUR. T1 - HLA-DQ Typing Kits in Diagnosis and Screening for Celiac Disease. AU - Rouvroye, Maxine D.. AU - van Zijtveld, Sander. AU - Bonnet, Petra. AU - Spierings, Eric. AU - Bontkes, Hetty J.. PY - 2019/6/1. Y1 - 2019/6/1. N2 - Aim: Celiac disease (CD) is strongly associated with HLA-DQ2.2, HLA-DQ2.5, and HLA-DQ8. Up to 99.7% of all CD patients are positive for either one or two of these genetic markers, demonstrating a high negative predictive value. This has led to the development of diagnostic kits that, instead of providing a full HLA-DQ typing, detect only these three HLA-DQ types. Our aim was to compare three different kits for their performance, utilization, and costs. Because 0.4-3.6% of all CD patients test positive for HLA-DQ7 and negative for the aforementioned types, information provided by the kits regarding DQ7 alpha and beta chains was evaluated as well. Materials and Methods: Fifty DNA samples previously typed with the SSCP method were analyzed using three commercial ...
HLA-DQ1 is a serotype that covers a broad range of HLA-DQ haplotypes. Historically it was identified as a DR-like alpha chain called DC1; later, it was among 3 types DQw1 (later DQ1, and split into DQ5 and DQ6), DQw2 and DQw3. Of these three serotyping specificities only DQw1 recognized DQ alpha chain. The serotype is positive in individuals who bear the DQA1*01 alleles. The most frequently found within this group are: DQA1*0101, *0102, *0103, and *0104. In the illustration on the right, DQ1 serotyping antibodies recognizes the DQ α (magenta), where antibodies to DQA1* gene products bind variable regions close to the peptide binding pocket. The serotyping efficiency of DQ1 recognition relative to DQ5 and DQ6 is listed below. Since DQ1 recognizes alpha, the DQ5 and DQ6 recognition are to beta chain. Meaning that DQ1 is corecognized with DQ5 and DQ6. The table to the left shows some of the serotyping efficiencies. Efficient recognition of a genotyped allele approaches 100%. Compared to DQ2 ...
Between July 2001 and May 2003, 187 mother and neonate pairs participated in this study. A total of 184 neonates completed the HLA-DR and -DQ genotyping. The frequencies of HLA-DR and -DQ genes, maternal sensitization, sIgE , 100 IU/ml, and cIgE ≥ 0.35 IU/ml were not different between the four areas. No association was found between cIgE and HLA-DR and -DQ genes or atopic symptoms. Physician diagnosed atopic symptoms were associated with the HLA-DQB1*02 allele (X2= 10.38, p,0.0013). After adjusting for possible potential risk factors, the sIgE , 100 IU/ml (Odds Ratio (OR) =5.01, 95% ci= [1.22, 27.14]), and HLA-DQB1*02 (OR = 8.09, 95% CI= [1.91, 36.74]) were risk factors for atopic symptoms in children at one year follow-up.. ...
At first glance, an association of a CD4 T cell-mediated disease with HLA class II gene products, whose function is to present peptides to CD4 T cells, appears easily explainable. Over the years, the most obvious, nonexclusive theories have been tested: instability and poor peptide binding of diabetogenic HLA class II molecules (6), unique peptide repertoire of the same molecules (7), T cells focused on the recognition of HLA-DQβ57 (8), failed thymic selection of autoreactive T cells (9), and abnormal T-cell binding to autoimmune peptide-MHC complexes (10). While all of those might bear truth and give some level of understanding of what the β57 residue might do, none could formally associate the mutation to a molecular mechanism leading to diabetes. The closest one to explaining the association of the same mutation with a disease was in the context of celiac disease, where the same HLA-DQ molecules are strongly predisposing to onset and also promote a frequent association with type 1 diabetes ...
CELI : LABType applies Luminex technology to the reverse sequence-specific oligonucleotide (SSO) DNA typing method. First, target DNA is PCR-amplified using a group-specific primer. The PCR product is biotinylated, which allows it to be detected using R-phycoerythrin-conjugated streptavidin. The PCR product is denatured and allowed to rehybridize to complementary DNA probes conjugated to fluorescently coded microspheres. A flow analyzer identifies the fluorescent intensity of phycoerythrin on each microsphere. The HLA Class II allele or allele groups of the sample is determined by the positive and negative bead IDs using a computer software program. The assignment of the HLA typing is based on the reaction pattern compared to patterns associated with published HLA gene sequences.(Package insert: One Lambda, LABType SSO Typing)
If patients could recognise themselves, or anyone else could recognise a patient from your description, please obtain the patients written consent to publication and send them to the editorial office before submitting your response [Patient consent forms] ...
In diseases with a strong association with an HLA haplotype, identification of relevant T cell epitopes may allow alteration of the pathologic process. In this report we use a reverse immunogenetic approach to predict possible HLA class II-restricted T cell epitopes by using complete pool sequencing data. Data from HLA-DR2(B1*1501), -DR3(B1*0301), -DQ2(A1*0501, B1*0201), and -DQ8(A1*0301, B1*0302) alleles were used by a computer program that searches a candidate protein to predict ligands with a relatively high probability of being processed and presented. This approach successfully identified both known T cell epitopes and eluted single peptides from the parent protein. Furthermore, the program identified ligands from proteins in which the binding motif of the HLA molecule was unable to do so. When the information from the nonbinding N- and C-terminal regions in the pool sequence was removed, the ability to predict several ligands was markedly reduced, particularly for the HLA-DQ alleles. This suggests
HLA-DQA1 belongs to the HLA class II alpha chain paralogues. The class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain…
Henry Erlich, Ana Maria Valdes, Janelle Noble, Joyce A. Carlson, Mike Varney, Pat Concannon, Josyf C. Mychaleckyj, John A. Todd, Persia Bonella, Anna Lisa Fear, Eva Lavant, Anthony Louey, Priscilla Moonsamy ...
Anti-Human HLA-DQ Antibody (1a3) - DyLight® 488 Product Benefits: ichorbios Anti-Human HLA-DQ Antibody (1a3) - DyLight® 488 is manufactured in a cGMP compl
So I finally had my appointment with Dr Lolitgas at Monash IVF. He went over my history and we discussed treatment plans. He has had hubby and I both tested for DQ Aplha gene match and we will find out hopefully on the 1st of Dec the - page 5
HLA-DQ DQ1 binding pocket with ligand major histocompatibility complex, class II, DQ Structure Type Cell surface receptor Quartenary αβ-heterodimer, ligand
Sep 20, 2002. In type 1 diabetes, certain HLA class II alleles or combinations of alleles.. In contrast, antigen-specific CD4+ helper T lymphocytes do
Unless indicated otherwise, all products are For Research Use Only and not for diagnostic or therapeutic use. Not for resale or transfer either as a stand-alone product or as a component of another product without written consent of EXBIO. EXBIO will not be held responsible for patent infringement or other violations that may occur with the use of our products. All orders are accepted subject to EXBIO s term and conditions which are available at www.exbio.cz ...
Rask, L., Andersson, D., Andersson, L., Gustafsson, K., Jonsson, A.-K., Larhammar, D., Servenius, G., and Peterson, P. A.: The evolution of human class II antigens as deduced from sequence analyses.In G. Kelsoe and D. H. Schulze (eds.):Evolution and Vertebrate Immunity. The Antigen-Receptor and MHC Gene Families. pp. 363-377, Texas University Press, 1987Google Scholar ...
Please state whether you are in agreeance or disagreeance w/ my answer to the DQ1 question and why? DQ question: 1. What - Answered by a verified Tutor
Coeliac disease (CD) development involves genetic (HLA-DQ2/DQ8) and environmental factors. Herein, the influence of the HLA-DQ genotype on the gut colonization process of breast-fed children was determined. A cohort of 20 newborns, with at least one first-degree relative with CD, were classified according to their HLA-DQ genotype into high, intermediate and low genetic risk groups, showing 24-28%, 7-8% and less than 1% probability to develop CD, respectively. Faecal microbiota was analysed at 7 days, 1 and 4 months of childrens age by fluorescence in situ hybridization. When considering all data, Gram-negative bacteria and Bacteroides-Prevotella group proportions were higher (P,0.05) in the high than in the intermediate and low genetic risk groups. E. coli, Streptococcus-Lactococcus, E. rectale-C. coccoides, sulphate-reducing bacteria, C. lituseburense and C. histolyticum group proportions were also significantly higher (P,0.05) in the high than in the low genetic risk group. Correlations ...
TY - JOUR. T1 - Genes within the HLA class II region confer both predisposition and resistance to primary biliary cirrhosis. AU - Begovich, A. B.. AU - Klitz, W.. AU - Moonsamy, P. V.. AU - Van de Water, Judith A. AU - Peltz, G.. AU - Gershwin, M. Eric. PY - 1994. Y1 - 1994. N2 - Nonradioactive sequence-specific oligonucleotide probes for the polymorphic HLA class II genes have been used to type samples from 51 Caucasian patients with the autoimmune liver disease, primary biliary cirrhosis, and 240 Caucasian controls. Although the allelic distribution at the DPB1 locus showed no significant variation between patients and controls, there was heterogeneity in the distribution of DR-DQ haplotypes where the frequency of the DRB1*0801-DQA1*0401/0601-DQB1*04 haplotype was significantly increased in the patients, suggesting it confers susceptibility to this disease. Two other haplotypes, DRB1*1501-DQA1*0102-DQB1*0602 and DRB1*1302-DQA1*0102-DQB1*0604, were significantly reduced in the patients, ...
HLA Class II DR, 0.1 mg. |p|HLA DR antigen is an HLA class II antigen with homology to murine H-2E. HLA-DR is an αβ heterodimer.
HLA DR3-DQ2 is double serotype that specifically recognizes cells from individuals who carry a multigene HLA DR, DQ haplotype. Certain HLA DR and DQ genes have known involvement in autoimmune diseases. DR3-DQ2, a multigene haplotype, stands out in prominence because it is a factor in several prominent diseases, namely coeliac disease and juvenile diabetes. In coeliac disease, the DR3-DQ2 haplotype is associated with highest risk for disease in first degree relatives, highest risk is conferred by DQA1*0501:DQB1*0201 homozygotes and semihomozygotes of DQ2, and represents the overwhelming majority of risk. HLA DR3-DQ2 encodes DQ2.5cis isoform of HLA-DQ, this isoform is described frequently as the DQ2 isoform, but in actuality there are two major DQ2 isoform. The DQ2.5 isoform, however, is many times more frequently associated with autoimmune disease, and as a result to contribution of DQ2.2 is often ignored. The frequency of both diseases changes with respect to both the environment (diet) and ...
Results 36/120 patients were excluded from analysis due to incomplete tTG and TPO testing. 84 patients with CD had sequential TTG and TPO analysis (mean age 48, 25 males, and median duration of follow-up 3 years). At baseline 19/84 (22.6%) had positive TPO (normal ,50 iu/ml) compared to 18/84 (21.4%) at follow-up. On analysis of tTG with unpaired t test, individuals with positive TPO had a trend towards higher tTG antibodies at baseline (229 vs 174, p=0.08) and a significantly higher tTG at follow-up (96 vs 44, p=0.03). We did not find any significant difference between TPO titres at diagnosis and follow-up (Mean TPO titre; at diagnosis=340, at follow-up=274, p=0.68). HLA status was tested on 88/120 patients (21/88 HLA DQ2 homozygotes, 61/88 HLA DQ2 heterozygotes and 6/88 were HLA DQ 8) Patients who were heterozygous for HLA DQ2 were significantly more likely than patients who were homozygous for HLA DQ8 to have raised TPO titres (21/61 heterozygotes were TPO positive compared to 2/21 ...
Background: We previously found that the introduction of small quantities of gluten at 4-6 mo of age did not reduce the risk of celiac disease (CD) in a group of high-risk children. However, the consumption of high amounts of gluten early in life has been suggested to increase CD risk.Objective: The aim of this study was to evaluate this hypothesis by using data from the previous study of the PreventCD trial (www.preventcd.com).Design: Gluten intake was prospectively quantified by using specific food records between 11 and 36 mo of age in 715 children positive for the human leukocyte antigen (HLA)-DQ2 and/or HLA-DQ8 from 5 European countries ...
Among the public health relevant disorders, Type 1 Diabetes (T1D) is a degenerative disease affecting almost 2 million Americans. It is characterized by the loss of insulin-producing b-cells due to a T cell-mediated autoimmune response. The risk to develop T1D is HLA associated. HLA-DQ8-DR4 has been identified as the most prevalent HLA haplotype in the Caucasian T1D population. Although DQ8 has been demonstrated to be the primary genetic determinant of disease susceptibility, its predisposing effect is likely modulated by the expression of closely linked DR4 alleles. As one of hypotheses to explain the role of DR4 molecules in T1D etiology, the peptide competition model holds that DR4 competes to bind diabetogenic peptides with DQ8 and thus affects DQ8-restricted autoreactive CD4 T cell responses. However, the evidence of the competition is insufficient due to the lack of detection reagents and the difficulty of segregating the expression of DR4 from DQ8. In this study, we investigated the ...
Histopathology of PLP-induced EAE in HLA DQB1*0602 Tg mouse. Samples were taken on day19 after immunization. Panel (A) shows the spinal cord, (B) the cerebellum
Genetic Typing. With the exception of DQ2 (*02:01) which has a 98% detection capability, serotyping has drawbacks in relative accuracy. In addition, for many HLA studies genetic typing does not offer that much greater advantage over serotyping, but in the case of DQ there is a need for precise identification of HLA-DQB1 and HLA-DQA1 which cannot be provided by serotyping. Isoform functionality is dependent on αβ composition. Most studies indicate a chromosomal linkage between disease causing DQA1 and DQB1 genes. Therefore, the DQA1, α, component is as important as DQB1. An example of this is DQ2, DQ2 mediates Coeliac disease and Type 1 diabetes but only if the α5 subunit is present. This subunit can be encoded by either DQA1*05:01 or DQA1*05:05. When the DQ2 encoding β-chain gene is on the same chromosome as the α5 subunit isoform, then individuals who have this chromosome have a much higher risk of these two disease. When DQA1 and DQB1 alleles are linked in this way they form a haplotype. ...
Mouse monoclonal Ovine MHC Class II DR antibody [37.68] validated for IP, IHC, Flow Cyt and tested in Human, Shp, Goat and Cow. Immunogen corresponding to…
HLA-DQ (MHC II) Antibody - With BSA and Azide, Mouse Monoclonal Antibody [Clone SPM422 ] validated in IHC, IF, FC (AH11428-20), Abgent
1. Gold, B. Origin and utility of the reverse dot-blot. Expert Rev. Mol. Diagn. 2003, 3, 143-152.. 2. Palomaki, G.E.; Bradley, L.A.; Richards, C.S.; Haddow, J.E. Analytic validity of cystic fibrosis testing: A preliminary estimate. Genet. Med. 2003, 5, 15-20.. 3. Zhang, Y.; Coyne, M.Y.; Will, S.G.; Levenson, C.H.; Kawasaki, E.S. Single-base mutational analysis of cancer and genetic diseases using membrane bound modified oli-gonucleotides. Nucleic Acids Res. 1991, 19, 3929-3933.. 4. Gillespie, D.; Spiegelman, S. A quantitative assay for DNA-RNA hybrids with DNA immobilized on a membrane. J. Mol. Biol. 1965, 12, 829 - 842.. 5. Saiki, R.K.; Bugawan, T.L.; Horn, G.T.; Mullis, K.B.; Erlich, H.A. Analysis of enzymatically amplified beta-globin and HLA-DQ alpha DNA with allele-specific oligonu-cleotide probes. Nature 1986, 324, 163-166.. 6. Saiki, R.K.; Chang, C.A.; Levenson, C.H.; Warren, T.C.; Boehm, C.D.; Kazazian, H.H., Jr.; Erlich, H.A. Diagnosis of sickle cell anemia and beta-thalassemia with ...
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Celiac disease (CD) has a prevalence of 1/100. Between 90-99% of Celiacs are HLA DQ2 and / or DQ8 positive. Every individual has two DQ serotypes. Because the molecular HLA nomenclature can be confusing DQ serotyping is a method for simplifying the results. There are four major types and 5 subtypes: HLA DQ1, DQ2, DQ3…. Details ...
The HLA (Human Leucocyte Antigen) system is the name given to the major histocompatibility complex (MHC) in man. The MHC complex is located on the short arm of the chromosome 6 and encodes three groups of molecules designated MHC class I, class II and class III.
The HLA (Human Leucocyte Antigen) system is the name given to the major histocompatibility complex (MHC) in man. The MHC complex is located on the short arm of the chromosome 6 and encodes three groups of molecules designated MHC class I, class II and class III.
Other HLA-encoded susceptibility determinants: The DR and DQ genes cannot completely explain the association between T1DM and the HLA gene region. Teasing out the contribution of other HLA loci, however, is complicated by the high level of linkage disequilibrium within the region, combined with the strong effects of DR and DQ. A number of different approaches have been employed to address this issue, including the analysis of case/control data matched for specific DR-DQ combinations, investigation of the transmission to affected and unaffected offspring of heterozygous markers from parents homozygous for DR-DQ alleles, conditional logistic regression and conditional haplotype analysis.. Read More » ...
The MHC in humans encodes the most polymorphic genes, the HLA genes, which are critical for the immune system to clear infection. This can be attributed to strong selection pressure as populations moved to different parts of the world and encountered
An unpaired ANOVA was utilized in the examination from the protein tyrosine kinase read full report information in Figure 8. For all other data, a paired ANOVA was made use of. Prism four for the Macintosh was made use of for all graphing and statistical calculations. Effects Characterization of GM M Monocytes are typically matured into M in vitro utilizing M CSF. On the other hand, AM are uncommon in they need GM CSF, but not M CSF, for his or her improvement in vivo. As a result, we followed the GM CSF based mostly differentiation protocol of Akagawa, et al., made to provide mono cyte derived M by using a distinctly AM like phenotype. The two AM and GM M happen to be proven to provide decrease levels of H2O2, express higher ranges of catalase and therefore are a lot more resistant to H2O2 toxicity when in comparison to M CSF derived M. Furthermore, AM and GM M express HLA DQ and are resistant to HIV infection, but prone to Myco bacterium tuberculosis infection. Finally, we are confident that ...
IM (ImmunoMolecular) Therapeutics is developing small molecules for the the treatment of type 1 diabetes mellitus (T1DM), positive for the HLA-DQ8 gene, and
摘要 试验旨在研究DQB2基因外显子2多态性与哈萨克羊布鲁氏菌病易感性的相关性。通过PCR-SSCP技术对146只布鲁氏菌阴性哈萨克羊血液样本和28只布鲁氏菌阳性哈萨克羊血液样本中的白细胞表面抗原DQB2基因外显子2的多态性进行研究,挑取不同的等位基因进行克隆测序,经卡方检验分析每个SNP位点的基因频率、基因型频率及其多态性与布鲁氏菌病易感性的相关性,应用生物信息学软件分析与哈萨克羊布鲁氏菌病易感性相关的不同等位基因的mRNA二级结构及蛋白质的二级结构、三级结构和抗原表位。结果发现,在270 ...
Gluten sensitivity is the only 100% confirmed cause of any autoimmune disease. Type 1 diabetes, like celiac disease, is an autoimmune disease. The HLA-DQ genotype risks for type 1 diabetes (juvenile diabetes) are the same for celiac disease. Gluten Free Society suggests that anyone who has a diagnosis of Type 1 Diabetes without a diagnosis of celiac disease avoid gluten and other grain based foods.. Remember the basis of how genes work. Gluten positive HLA-DQ genes means that you should avoid grain to prevent the onset of illness. Having the positive HLA-DQ genes for type I diabetes or celiac disease does not mean that you will develop these conditions. However; gluten positive genes are related to over 190 conditions. Diabetes and celiac disease are just 2 diseases in a long list of problems that can develop.. If you are confused on this issue, we highly recommend you watch this video on gluten sensitivity.. If you have been diagnosed with Type I diabetes and want to determine your HLA-DQ ...
The RV144 vaccine produced two Env-specific antibody responses that correlated with HIV-1 acquisition (3). Because HLA class II molecules are important in the initiation of antibody responses, we hypothesized that variation in HLA class II genes might influence response to the vaccine. DRB1, DQB1, and DPB1 loci were typed in the RV144 vaccine recipients, and the alleles found were tested for an effect on magnitude of vaccine-induced responses and for interactions with the two vaccine-elicited immune responses that significantly affected HIV-1 acquisition. Both Env-specific antibody responses previously identified were found to correlate with HIV-1 acquisition only in the presence of specific HLA class II alleles.. Haynes et al. (3) observed that high levels of IgA antibody binding to Env correlated with reduced vaccine efficacy that was not distinguishable from the placebos in RV144. Here, we report that it is only in the presence of a single allele, DQB1*06, that high levels of Env-specific IgA ...
article{dd946182-cc9b-45da-80fe-824daa64be35, abstract = {,p,Most patients with celiac disease are positive for either HLA-DQA1*05:01-DQB1*02 (DQ2.5) or DQA1*03:01-DQB1*03:02 (DQ8). Remaining few patients are usually DQA1*02:01-DQB1*02 (DQ2.2) carriers. Screenings of populations with high frequencies of these HLA-DQA1-DQB1 haplotypes report a 1% to 3% celiac disease prevalence. The aim was to determine the prevalence of HLA-DQ risk haplotypes for celiac disease in Ethiopian children. Dried blood spots collected from 1193 children from the Oromia regional state of Ethiopia were genotyped for HLA-DQA1 and DQB1 genotyping using an asymmetric polymerase chain reaction (PCR) and a subsequent hybridization of allele-specific probes. As references, 2000 previously HLA-genotyped children randomly selected from the general population in Sweden were included. DQ2.2 was the most common haplotype and found in 15.3% of Ethiopian children, which was higher compared with 6.7% of Swedish references (P ...
TY - JOUR. T1 - The role of HLA-DQ8 β57 polymorphism in the anti-gluten T-cell response in coeliac disease. AU - Hovhannisyan, Zaruhi. AU - Weiss, Angela. AU - Martin, Alexandra. AU - Wiesner, Martina. AU - Tollefsen, Stig. AU - Yoshida, Kenji. AU - Ciszewski, Cezary. AU - Curran, Shane A.. AU - Murray, Joseph A.. AU - David, Chella S.. AU - Sollid, Ludvig M.. AU - Koning, Frits. AU - Teyton, Luc. AU - Jabri, Bana. N1 - Funding Information: Acknowledgements We thank S. Sadegh-Nasseri for advice and discussion, and A. Bendelac and M. Mush for critical reading of the manuscript. This work was supported by the Digestive Disease Research Core Center of the University of Chicago (DK42086), NIH DK67180, DK55037, the Celiac Disease Consortium (F.K.), EU MC-RTN 512385 (M.W.), the Research Council of Norway (L.S.) and the University of Oslo (S.T.).. PY - 2008/11/27. Y1 - 2008/11/27. N2 - Major histocompatibility complex (MHC) class II alleles HLA-DQ8 and the mouse homologue I-Ag7 lacking a canonical ...
Compared with healthy controls (odds ratios analyses), SLE-SS and pSS patients displayed a statistically increased frequency of the DRB1*0301-*1104 heterozygote genotype, whereas SLE-noSS patients had an increased frequency of the genotypes DQA1*0401-*0501, DRB1*0301-*1501 and DQB1*0201-*0602. Such statistical associations were stronger for genotypes than single alleles. The analysis of haplotype estimated frequencies (by EM algorithm) had revealed an increased frequency of the DRB1*0301-DQA1*0501-DQB1*0201 haplotype, as well as of the extended haplotype DRB1*0301-DQA1*0501-DQB1*0201/DRB1*1104-DQA1*0501-DQB1*0301 in SLE-SS and pSS patients. In contrast, SLE-noSS patients had an increased estimated frequency of the DRB1*1501-DQA1*0102-DQB1*0602 haplotype. In SLE-SS patients, positive associations of the DQB1*0201 allele with anti-dsDNA (strong) and of DQA1*0501 with anti-La/SSB (marginal) were observed. In SLE-noSS, DQB1*0301-*0602 was strongly positively associated with interstitial lung ...
BACKGROUND: Susceptibility to celiac disease is essentially restricted to carriers of specific HLA DQA1 and DQB1 alleles. We have developed a semi-automated sequence specific primer (SSP) PCR method for clinical HLA typing and compared the test results with those from a commercial method. METHODS: Primers for each DQA1 and DQB1 allele group were included in our PCR-SSP reaction to allow differentiation of homozygous from heterozygous carriers of risk alleles. Primers detecting the tightly linked DRB1*04, *03, *07 and *09 alleles were included to resolve potentially ambiguous results. Fluorescently labeled PCR products of 119 clinical samples were analyzed by capillary electrophoresis, and results were compared to those previously obtained from the DELFIA® Type 1 Diabetes Genetic Predisposition assay. RESULTS: The risk assessment derived from the two methods was 100% concordant. One previously unreported haplotype was detected and haplotype assignments in two of the 119 samples were improved ...
Researchers from Dublin, Ireland, investigated the natural course of hepatitis C virus (HCV) infection among a cohort of Irish women.. All individuals were infected with the HCV genotype 1b via contaminated anti-D immunoglobulin in 1977.. The team assessed the clinical status of 87 polymerase chain reaction (PCR)-positive and 68 PCR-negative women at diagnosis (1994/95). This was also conducted after 4-5 years of follow-up (21/22 years after inoculation). Other features investigated included: histological status/progression, psychosocial impact of HCV infection, extrahepatic manifestations, and HLA class II associations.. The most common symptoms reported were fatigue and arthralgia. Furthermore, 77% of women fell within the clinical range for psychological distress. A history of icteric hepatitis was reported in 21% of PCR-negative and 3% of PCR-positive women after inoculation. The mean histological activity index/fibrosis scores of PCR-positive and negative women were 4.1/1.1 and 2.1/0.15 at ...
Celiac disease is common in Saudi Arabia, affecting about 1.5% of the countrys total population. A new study shows that more than half the healthy general Saudi population carry celiac disease-predisposing HLA-DQ genotypes; thats one of the highest general rates in the world. How will this reality shape the diagnosis and treatment in the country?
HLA-DQA1 belongs to the HLA class II alpha chain paralogues. The class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B Lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa. It is encoded by 5 exons; exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation. [provided by RefSeq, Jul 2008 ...
HLA-DQA1 belongs to the HLA class II alpha chain paralogues. The class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B Lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa. It is encoded by 5 exons; exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation. [provided by RefSeq, Jul 2008 ...
Results CD was diagnosed in 4 of 95 patients with JIA (4.2%), a rate significantly higher compared with controls (p,0.02) and 14 times higher than in the general population. Twenty-six patients (27.4%) had one of the variants of the risk genotypes. All four patients diagnosed with CD had a HLA-DQ2.5 genotype: one was homozygote, the remainder heterozygote. Twenty-two patients are, judging by their HLA genotypes, at risk of developing CD and require repeated serological screening. None of the 69 patients without HLA-DQ2/DQ8 genotypes had CD-specific antibodies. Screening with HLA genotyping becomes cheaper than screening without after the second determination. ...
Celiac disease (DC) is a permanent intolerance to gluten characterized by an inflammatory reaction in the mucosa of the small intestine caused by an immune response that hinders the absorption of macro and micronutrients. The most frequent symptoms of CD are weight loss and appetite, fatigue, nausea, vomiting, diarrhea, abdominal distension and pain, loss of muscle mass, delayed growth and depression, among others. CD occurs in individuals with a genetic predisposition. About 90% of patients with celiac disease are HLA-DQ2 positive, while the others have allelic variants that encode HLA-DQ8 without HLADQ2 (6%) or only one HLA-DQ2 allele. Therefore, genetic analysis is extremely important to aid in the confirmation of diagnostic suspicion.. ...
Mouse monoclonal antibody raised against native HLA-DQA1. Native purified HLA-DQA1 from whole cells from the B line WT46. (MAB7017) - Products - Abnova
Mouse monoclonal antibody raised against a partial recombinant HLA-DQB1. HLA-DQB1 (AAH12106.1, 129 a.a. ~ 217 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. (H00003119-M02) - Products - Abnova
p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.,/p> ,p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.,/p> ,p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).,/p> ,p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x,sup>64,/sup> + x,sup>4,/sup> + x,sup>3,/sup> + x + 1. The algorithm is described in the ISO 3309 standard. ,/p> ,p class=publication>Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.,br /> ,strong>Cyclic redundancy and other checksums,/strong>,br /> ,a href=http://www.nrbook.com/b/bookcpdf.php>Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993),/a>),/p> Checksum:i ...
p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.,/p> ,p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.,/p> ,p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).,/p> ,p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x,sup>64,/sup> + x,sup>4,/sup> + x,sup>3,/sup> + x + 1. The algorithm is described in the ISO 3309 standard. ,/p> ,p class=publication>Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.,br /> ,strong>Cyclic redundancy and other checksums,/strong>,br /> ,a href=http://www.nrbook.com/b/bookcpdf.php>Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993),/a>),/p> Checksum:i ...
SwePub titelinformation: Population analysis of protection by HLA-DR and DQ genes from insulin-dependent diabetes mellitus in Swedish children with insulin-dependent diabetes and controls
HLA-DQB1 description, symptoms and related genes. Get the complete information in our medical search engine for phenotype-genotype relationships
The Type I Diabetes Genetics Consortium Rapid Response family-based candidate gene study: strategy, genes selection, and main outcome. ...
HLA-DQB2 antibody (major histocompatibility complex, class II, DQ beta 2) for IHC-P, WB. Anti-HLA-DQB2 pAb (GTX104461) is tested in Human samples. 100% Ab-Assurance.
HLA-DQ2, a human leukocyte antigen of the HLA DQ type. This disambiguation page lists articles associated with the same title ...
HLA-DQ is part of the MHC class II antigen-presenting receptor (also called the human leukocyte antigen) system and ... The two subunits of the HLA-DQ protein are encoded by the HLA-DQA1 and HLA-DQB1 genes, located on the short arm of chromosome 6 ... but as a negative HLA-DQ type excludes the diagnosis of coeliac disease, testing also for HLA-DQ2 or DQ8 maximises sensitivity ... Only the HLA-DQ loci show a consistent involvement over the global population. Many of the loci detected have been found in ...
... amplification and human leukocyte antigen (HLA)-DQ alpha oligonucleotide typing on biological evidence samples: casework ... The DQ alpha 1 locus (or location) was also polymorphic and had multiple different alleles that could be used to limit the pool ... The DQ alpha locus was combined with other loci in a commercially available kit called Polymarker in 1993. Polymarker was a ... Developed in 1991, DQ alpha testing was the first forensic DNA technique that utilized the polymerase chain reaction. This ...
... high-resolution and large sample typing of HLA DR-DQ haplotypes in a sample of European Americans". Tissue Antigens. 62 (4): ... The haplotype HLA-DR4-DQ3 appears to play a role in the pathogenic AAHA production. The alleles primarily recognized are HLA- ... HLA-DR7 may also be associated with these antibodies and the common haplotype association is the HLA-DR53 serotype. Viard JP, ... 2000). "HLA class II alleles associations of anticardiolipin and anti-beta2GPI antibodies in a large series of European ...
HLA-DQ2 primarily presents gliadins with the HLA-DQ isoform DQ2.5 (DQ α5-β2) isoform. DQA1*0202:DQB1*0201 homozygotes (DQ α2-β2 ... The HLA-A antigens can mediate apoptosis in autoimmune disease and HLA A*0201 in with the HLA-DQ8 haplotypes has been ... and therefore HLA-DQ can recognize many motifs on each gliadin (see Understanding DQ haplotypes and DQ isoforms on the right) ... Understanding DQ haplotypes and DQ isoforms). HLA-DQ8 is generally not as involved in the most severe complications, and it ...
The HLA-DQ proteins that predispose individuals to coeliac disease bind and respond specifically to gluten-related antigens ... HLA-DQ proteins are composed of α and β polypeptide chains encoded by the HLA-DQA1 and HLA-DQB1 genes, respectively. Since ... Ninety to one hundred percent of patients with coeliac disease have inherited genes at the HLA-DQ locus that encode HLA-DQ2 and ... HLA-DQ proteins are on the surface of APC and function to present foreign or self antigens to the T cell receptors (TCR) ...
... a human leukocyte antigen of the HLA-DQ type. This disambiguation page lists articles associated with the same title formed as ... DQ3 may be: Deltora Quest 3, a children's book Dragon Quest III, a console role-playing game (RPG) HLA-DQ3, ...
... or the HLA-DQ (alpha 1*03, beta 1*0302) heterodimers". Tissue Antigens. 49 (1): 29-34. doi:10.1111/j.1399-0039.1997.tb02706.x. ... and is associated with the human leukocyte antigen (HLA) haplotype HLA-DQ2 or HLA-DQ8 along with coeliac disease and gluten ... tTG is treated as an autoantigen, especially in people with certain HLA-DQ2 and HLA-DQ8 alleles and other gene variants that ... "Dermatitis herpetiformis and celiac disease are both primarily associated with the HLA-DQ (alpha 1*0501, beta 1*02) ...
... a Human leukocyte antigen HLA-DQ serotype that recognizes the DQB1*04 gene products This disambiguation page lists articles ... DQ4 could refer to: Dragon Quest IV: Chapters of the Chosen, a video game published by Enix (now Square Enix) HLA-DQ4, ...
"Frequencies of HLA-A, HLA-B, HLA-DR, and HLA-DQ phenotypes in the United Arab Emirates population". Tissue Antigens. 66 (2): ... HLA-C. Minor genes are HLA-E, HLA-F and HLA-G. β2-microglobulin binds with major and minor gene subunits to produce a ... HLA-DR *α-chain encoded by HLA-DRA locus. *4 β-chains (only 3 possible per person), encoded by HLA-DRB1, DRB3, DRB4, DRB5 loci ... HLA-DQ2 and HLA-DQ8. Coeliac disease. 7[6]. In autoimmunity[edit]. HLA types are inherited, and some of them are connected with ...
Studies on the polymorphisms of human leukocyte antigen (HLA)-DR and HLA-DQ gene regions in Sjögren's patients show ... Patients of different ethnic origin carry different HLA-susceptibility alleles, of which HLA-DR and HLA-DQ are involved in the ... HLA-DQ2 and HLA-B8 are generally found in Caucasian patients, while HLA-DR5 is related to Greek and Israeli patients. Multiple ... Dendritic cells are antigen-presenting cells that process antigen material and present it to other T cells. Following the ...
Atlanta Falcons Head Coach HLA DQ, a human leukocyte antigen type protein Data quality, various measures in information science ... IATA code DQ) DQ (artist), Danish singer, participant in Eurovision Song Contest 2007 Dan Quayle, American politician Dulquer ... FIPS PUB 10-4 territory code DQ) This disambiguation page lists articles associated with the title DQ. If an internal link led ... DQ may stand for: Dragon Quest, a series of console role-playing games created by Enix (now Square Enix) DragonQuest, a role- ...
Prior to refined typing for HLA-DQ and DR, the association with HLA-A1 and B8 was identified for coeliac disease in 1973 and ... "Correlation between acetylcholine receptor antibody titer and HLA-B8 and HLA-DRw3 antigens in myasthenia gravis". Trans Am ... 1995). "Different HLA-DQ are positively and negatively associated in Swedish patients with myasthenia gravis". Autoimmunity. 22 ... In one study 65% of patients with end stage autoimmune hepatitis had coeliac associated HLA-DQ (DQ2, DQ8), of these half had ...
DQw3 was one of three early determined antigens recognized as HLA-DQ along with HLA-DQ1 and HLA-DQ2. While the DQ3 molecules ... HLA-DQ3 (DQ3) is a broad serotype category with split antigens HLA-DQ7, DQ8, and DQ9. Historically, originally recognized as ... DQB1*0301 the DQ7 gene, is detailed on HLA-DQ7 DQB1*0302 the DQ8 gene, is detailed on HLA-DQ8 DQB1*0303 the DQ9 gene, is ... detailed on HLA-DQ9 DQB1*0304 is similar in structure and function to DQB1*0301 generally considered to be HLA-DQ7 DQB1*0305 is ...
... (DQ9) is a human leukocyte antigen serotype within the HLA-DQ (DQ) serotype group. DQ9 is a split antigen of the DQ3 ... derived from IMGT/HLA Zhai L, Sun Y, Tang L, Liu H (2007). "Polymorphism between loci for human leukocyte antigens DR and DQ in ... Törn C, Gupta M, Sanjeevi CB, Aberg A, Frid A, Landin-Olsson M (2004). "Different HLA-DR-DQ and MHC class I chain-related gene ... 1994). "Analysis of MHC class II antigens in Japanese IDDM by a novel HLA-typing method, hybridization protection assay". ...
DR16 is part of the older HLA-DR2 serotype group which also contains the similar HLA-DR15 antigens. DR16 is associated with ... Park M, Park Y, Song E, Park H, Kim T, Park D, Park K, Cho B (2005). "Association of HLA-DR and -DQ genes with Graves disease ... systemic sclerosis HLA-DR16 is genetically linked to HLA-DR51 and HLA-DQ5 serotypes. derived from IMGT/HLA Cruz-Robles D, Reyes ... Dharakul T, Vejbaesya S, Chaowagul W, Luangtrakool P, Stephens H, Songsivilai S (1998). "HLA-DR and -DQ associations with ...
"HLA-DR antigens in pemphigus among Japanese". Tissue Antigens. 17 (2): 238-9. doi:10.1111/j.1399-0039.1981.tb00689.x. PMID ... Hermann R, Turpeinen H, Laine A, Veijola R, Knip M, Simell O, Sipilä I, Akerblom H, Ilonen J (2003). "HLA DR-DQ-encoded genetic ... HLA-DR4 (DR4) is an HLA-DR serotype that recognizes the DRB1*04 gene products. The DR4 serogroup is large and has a number of ... derived from IMGT/HLA Roudier J (2006). "HLA-DRB1 genes and extraarticular rheumatoid arthritis". Arthritis Research & Therapy ...
"Strong associations between specific HLA-DQ and HLA-DR alleles and the tubulointerstitial nephritis and uveitis syndrome". ... "HLA-DR antigens in rheumatoid arthritis. A Swiss collaborative study; final report. Swiss Federal Commission for the Rheumatic ... HLA-DR1 is not genetically linked to DR51, DR52 or DR53, but is linked to HLA-DQ1 and DQ5 serotypes. Fernández MM, Guan R, ... HLA-DR1 (DR1) is a HLA-DR serotype that recognizes the DRB1*01 gene products. It has been observed to be common among ...
HLA class II histocompatibility antigen, DP(W2) beta chain is a protein that in humans is encoded by the HLA-DPB1 gene. HLA-DPB ... 1992). "Family study on HLA-DPB1 polymorphism: linkage analysis with HLA-DR/DQ and two "new" alleles". Hum. Immunol. 34 (3): ... 1991). "Modulation of the HLA class II antigen at a molecular level by maternal serum among cord blood cells and unrelated ... Eiermann TH, Uhl S, Fakler J, Goldmann SF (1992). "A novel HLA-DPB1 sequence, DPB1*2301". Tissue Antigens. 40 (2): 108-10. doi: ...
... high-resolution and large sample typing of HLA DR-DQ haplotypes in a sample of European Americans". Tissue Antigens. 62 (4): ... HLA-DQ7 (DQ7) is an HLA-DQ serotype that recognizes the common HLA DQB1*0301 and the less common HLA DQB1*0304 gene products. ... a large number of DQ αβ isoforms. These DQ alpha chains are also known to form transhaplotype isomers with other HLA-DQ. DQ7 is ... Guo X, Ni P, Li L (2001). "[Association between asthma and the polymorphism of HLA-DQ genes]". Zhonghua Jie He He Hu Xi Za Zhi ...
... high-resolution and large sample typing of HLA DR-DQ haplotypes in a sample of European Americans". Tissue Antigens. 62 (4): ... HLA-DQ2 (DQ2) is a serotype group within HLA-DQ (DQ) serotyping system. The serotype is determined by the antibody recognition ... The β-chain of DQ is encoded by HLA-DQB1 locus and DQ2 are encoded by the HLA-DQB1*02 allele group. This group currently ... HLA-DQ2 and HLA-DQB1*02 are almost synonymous in meaning. DQ2 β-chains combine with α-chains, encoded by genetically linked HLA ...
... is composed of the HLA-DR17 and HLA-DR18 split 'antigens' serotypes. DR3 is a component gene-allele of the AH8.1 ... DR3-DR2 is the serological marker for HLA-DQ2.5cis isoform. Although it cannot identify the alpha ".5" chain of HLA DQ, DQA1* ... Type 1 diabetes mellitus is strongly associated with HLA-DR3 or HLA-DR4. Some DR3 also react with HLA-DR17 and/or HLA-DR18. The ... 2007). "Primary sclerosing cholangitis is associated with extended HLA-DR3 and HLA-DR6 haplotypes". Tissue Antigens. 69 (2): ...
DQ beta 2". Piatier-Tonneau D, Gastinel LN, Amblard F, et al. (1991). "Interaction of CD4 with HLA class II antigens and HIV ... HLA class II histocompatibility antigen, DX beta chain is a protein that in humans is encoded by the HLA-DQB2 gene. ... 1994). "HLA class II antigens and the HIV envelope glycoprotein gp120 bind to the same face of CD4". J. Immunol. 152 (9): 4475- ... Comparisons of the DQ and DX alpha and beta genes". J. Biol. Chem. 262 (18): 8767-77. PMID 3036828. Andrieu JM, Even P, Venet A ...
... (DQ6) is a human leukocyte antigen serotype within HLA-DQ (DQ) serotype group. The serotype is determined by the ... Achord AP, Lewis RE, Brackin MN, Henderson H, Cruse JM (1996). "HIV-1 disease association with HLA-DQ antigens in African ... The β-chain of DQ isoforms are encoded by HLA-DQB1 locus and DQ6 are encoded by the HLA-DQB1*06 allele group. This group ... 2000). "HLA-DR and -DQ associations with insulin-dependent diabetes mellitus in a population of Turkey". Hum. Immunol. 61 (3): ...
... high-resolution and large sample typing of HLA DR-DQ haplotypes in a sample of European Americans". Tissue Antigens. 62 (4): ... Antigens most responsible for graft loss are HLA-DR (first six months), HLA-B (first two years), and HLA-A (long-term survival ... The HLA-DRB4 locus encodes the HLA-DR53 specificity, has some variation, and is associated with certain HLA-DRB1 types. The HLA ... and at the HLA-DRB1 locus to a greater degree relative to HLA-DQB1 and HLA-DPB1. Most of the HLA alleles currently present in ...
HLA class II histocompatibility antigen, DQ(6) alpha chain is a protein that in humans is encoded by the HLA-DQA2 gene. Also ... 1987). "Structure and expression of HLA-DQ alpha and -DX alpha genes: interallelic alternate splicing of the HLA-DQ alpha gene ... 1994). "HLA class II antigens and the HIV envelope glycoprotein gp120 bind to the same face of CD4". J. Immunol. 152 (9): 4475- ... "Entrez Gene: HLA-DQA2 major histocompatibility complex, class II, DQ alpha 2". Rudy GB, Lew AM (March 1997). "The ...
HLA-DR, -DQ and -DP) in Japanese patients with histiocytic necrotizing lymphadenitis (Kikuchi's disease)". Tissue Antigens. 54 ... HLA-DQ4 (DQ4) is a serotype subgroup within HLA-DQ(DQ) serotypes. The serotype is determined by the antibody recognition of β4 ... subset of DQ β-chains. The β-chain of DQ is encoded by HLA-DQB1 locus and DQ4 are encoded by the HLA-DQB1*04 allele group. This ... HLA-DQ4 and HLA-DQB1*04 are almost synonymous in meaning. DQ4 β-chains combine with α-chains, encoded by genetically linked HLA ...
... is a serotype that covers a broad range of HLA-DQ haplotypes. Historically it was identified as a DR-like alpha chain ... 1992). "Association of HLA-B51 and lack of association of class II alleles with Behçet's disease". Tissue Antigens. 40 (1): 22- ... Olerup O, Olsson R, Hultcrantz R, Broome U (1995). "HLA-DR and HLA-DQ are not markers for rapid disease progression in primary ... 1994). "HLA-DQA1, -DQB1 and -DRB1 genotyping in Japanese pemphigus vulgaris patients by the PCR-RFLP method". Tissue Antigens. ...
... (DQ8) is a human leukocyte antigen serotype within the HLA-DQ (DQ) serotype group. DQ8 is a split antigen of the DQ3 ... "Frequencies of HLA-A, HLA-B, HLA-DR, and HLA-DQ phenotypes in the United Arab Emirates population". Tissue Antigens. 66 (2): ... Pimtanothai N, Hurley C, Leke R, Klitz W, Johnson A (2001). "HLA-DR and -DQ polymorphism in Cameroon". Tissue Antigens. 58 (1 ... October 2003). "New HLA haplotype frequency reference standards: high-resolution and large sample typing of HLA DR-DQ ...
... (DQ5) is a human leukocyte antigen serotype subgroup within HLA-DQ(DQ) serotypes. The serotype is determined by the ... Wang JF, Zhang D, Zhao JZ, Jia BX, Bi RM (2006). "A study on the relationship between HLA-DR, DQ antigen, and intracranial ... The β-chain of DQ is encoded by HLA-DQB1 locus and DQ5 are encoded by the HLA-DQB1*05 allele group. This group currently ... HLA-DQ5 and HLA-DQB1*05 are almost synonymous in meaning. DQ5 β-chains combine with α-chains, encoded by genetically linked HLA ...
HLA-DQ is part of the MHC class II antigen-presenting receptor (also called the human leukocyte antigen) system and ... The two subunits of the HLA-DQ protein are encoded by the HLA-DQA1 and HLA-DQB1 genes, located on the short arm of the sixth ... but as a negative HLA-DQ type excludes the diagnosis of coeliac disease, testing also for HLA-DQ2 or DQ8 maximises sensitivity ... Only the HLA-DQ loci show a consistent involvement over the global population.[69] Many of the loci detected have been found in ...
... is part of a family of genes called the human leukocyte antigen (HLA) complex. The HLA complex helps the immune system ... HLA-B*45ZJ, HLA-B-3506, HLA-B-3905, HLA-B-5502, HLA-B-5602, HLA-B15, HLA-B39, HLA-B49, HLA-B50, HLA-B55, HLA-B59, HLA-B61, HLA- ... They are HLA-A, HLA-B, (both Class I MHCs) and HLA-DR (a Class II MHC).[5] If the two tissues have the same genes coding for ... In humans, the HLA-B gene and two related genes, HLA-A and HLA-C, are the major genes in MHC class I. ...
"An extensive screen of the HLA region reveals an independent association of HLA class I and class II with susceptibility for ... Pan HF, Wu GC, Li WP, Li XP, Ye DQ (February 2009). "High Mobility Group Box 1: a potential therapeutic target for systemic ... In close proximity to TBM, follicular dendritic cells (FDC) are localised in GC, which attach antigen material to their surface ... HLA class I, class II, and class III genes are associated with SLE, but only classes I and II contribute independently to ...
DQ representation is similar to non-RCD celiacs.. *RCD 2 involves neoplastic tissues that the lack of surface expression of ... 2007). "HLA-DQB1*0201 homozygosis predisposes to severe intestinal damage in celiac disease". Scand. J. Gastroenterol. 42 (1): ... Al-Toma A, Goerres MS, Meijer JW, Peña AS, Crusius JB, Mulder CJ (2006). "Human leukocyte antigen-DQ2 homozygosity and the ... Bao F, Yu L, Babu S, Wang T, Hoffenberg EJ, Rewers M, Eisenbarth GS (1999). "One third of HLA DQ2 homozygous patients with type ...
"HLA and narcolepsy in a German population." Tissue Antigens. 1986 sep;28(3):163-9. PMID 3641479 ... HLA-DQ 0602ren egitura kristalinoa hipokretina peptidoari lotuta[3][4]. Narkolepsia karaktere genetikoarekin loturik zegoenaren ... "Crystal structure of HLA-DQ0602 that protects against type 1 diabetes and confers strong susceptibility to narcolepsy." ... Ezin izan da baieztatu sindrome honen jarrera fisiopatologikoak (gaixotasun aske klasikoekin lotuta daudenak), hauek HLA-rekin ...
... (DQ) is encoded on the HLA region of chromosome 6p21.3, in what was classically known as the "D" antigen region. This ... The DQ loci are in close genetic linkage to HLA-DR, and less closely linked to HLA-DP, HLA-A, HLA-B and HLA-C. ... HLA-DQ (DQ) is a cell surface receptor protein found on antigen presenting cells. It is an αβ heterodimer of type MHC class II ... HLA DQ functions as a cell surface receptor for foreign or self antigens. The immune system surveys antigens for foreign ...
SAgs show preference for the HLA-DQ form of the molecule.[8] Binding to the α-chain puts the SAg in the appropriate position to ... One mechanism by which this is done is through inducing anergy of the T-cells to antigens and SAgs.[13][16] Lussow and ... This occurs because a cognate antigen activates a T cell not because of its structure per se, but because its affinity allows ... SAg stimulation of antigen presenting cells and T-cells elicits a response that is mainly inflammatory, focused on the action ...
HLA class II histocompatibility antigen, DRB5 beta chain is a protein that in humans is encoded by the HLA-DRB5 gene.[5] ... antigen processing and presentation. • antigen processing and presentation of exogenous peptide antigen via MHC class II. • ... HLA-DRB5, HLA-DRB, major histocompatibility complex, class II, DR beta 5, HLA-DRB5* ... 1991). "Interaction of CD4 with HLA class II antigens and HIV gp120". Immunogenetics. 34 (2): 121-8. doi:10.1007/BF00211424. ...
... patients should be tested for the presence of HLA-DQ2/DQ8 genetic markers because a negative HLA-DQ2 and HLA-DQ8 result has a ... the main cytotoxic antigen of gluten), but also other proteins named amylase/trypsin inhibitors (ATIs) which are present in ... of people with NCGS presenting with HLA-DQ2 and/or HLA-DQ8 haplotypes, negative serology, and normal histology or duodenal ... but such a diagnosis is unlikely without confirming HLA-DQ2 and/or HLA-DQ8 haplotypes.[31] ...
... the main cytotoxic antigen of gluten), but also other proteins named ATIs which are present in gluten-containing cereals (wheat ... HLA-DQ. *HLA-DQ2. *HLA-DQ8. Other. *Gluten immunochemistry. *Gluten-free diet ...
Human leukocyte antigen. MHC class I. *HLA-A. *HLA-B. *HLA-C ... In humans, the HLAs corresponding to MHC class I are HLA-A, HLA ... HLA-E, -F, and -G) as well as MHC class I pseudogenes arose from MHC class Ia loci (HLA-A, -B, and -C) in this birth-and-death ... Only the α chain is polymorphic and encoded by a HLA gene, while the b2m subunit is not polymorphic and encoded by the Beta-2 ... Hughes AL (March 1995). "Origin and evolution of HLA class I pseudogenes". Molecular Biology and Evolution. 12 (2): 247-58. doi ...
Studies on the polymorphisms of human leukocyte antigen (HLA)-DR and HLA-DQ gene regions in SS patients show differential ... Patients of different ethnic origin carry different HLA susceptibility alleles, of which, HLA-DR and HLA-DQ are involved in the ... HLA-DQ2 and HLA-B8 are generally found in Caucasian patients, while HLA-DR5 is related to Greek and Israeli patients.[59] ... Fei HM, Kang H, Scharf S, Erlich H, Peebles C, Fox R. "Specific HLA-DQA and HLA-DRB1 alleles confer susceptibility to Sjögren's ...
6p21.3) HLA-DQA1 and HLA-DQB1 form HLA-DQ heterodimer MHC class II, DQ: Celiac1, IDDM (6p21.3) HLA-DRA, HLA-DRB1, HLA-DRB3, HLA ... HLA-Cw*06:02: gene variation related to psoriasis (6p21.3) LY6G6E encoding protein Lymphocyte antigen 6 complex, locus G6E ( ... HLA-DRB5 forms HLA-DR, heterodimer MHC class II, DR (6p21.3) HLA-DPA1 and HLA-DPB1 forms HLA-DP, MHC class II, DP (6p21.3) ... HLA-A, HLA-B, HLA-C: major histocompatibility complex (MHC), class I, A, B, and C loci. ( ...
SAgs show preference for the HLA-DQ form of the molecule. Binding to the α-chain puts the SAg in the appropriate position to ... SAg stimulation of antigen presenting cells and T-cells elicits a response that is mainly inflammatory, focused on the action ... Compared to a normal antigen-induced T-cell response where 0.0001-0.001% of the body's T-cells are activated, these SAgs are ... This occurs because a cognate antigen activates a T cell not because of its structure per se, but because its affinity allows ...
Major histocompatibility complex Human leukocyte antigen HLA-DQ ENSG00000206305, ENSG00000225890, ENSG00000232062, ... 1987). "Complete sequence of the HLA DQ alpha and DQ beta cDNA from a DR5/DQw3 cell line". J. Immunol. 139 (1): 228-33. PMID ... rare among serotypes for human class II antigens, in that the antibodies to DQ1 react to the alpha chain of HLA DQ, these DQA1 ... "Entrez Gene: HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1". Lau M, Terasaki PI, Park MS (1994). " ...
... and less closely linked to HLA-DP, HLA-A, HLA-B and HLA-C. Different isoforms of DQ can bind to and present different antigens ... HLA-DQ (DQ) is encoded on the HLA region of chromosome 6p21.3, in what was classically known as the "D" antigen region. This ... HLA-DQ (DQ) is a cell surface receptor protein found on antigen-presenting cells. It is an αβ heterodimer of type MHC class II ... HLA DQ functions as a cell surface receptor for foreign or self antigens. The immune system surveys antigens for foreign ...
Those peptides expressing a drug-related, non-self epitope on their HLA-A, HLA-B, HLA-C, HLA-DM, HLA-DO, HLA-DP, HLA-DQ, or HLA ... places the peptides in a groove on the human leukocyte antigen (i.e. HLA) component of their major histocompatibility complex ( ... Phenytoin: Han Chinese individuals expressing HLA-B13:01, HLA-B51:01, HLA-B15:02, HLA-Cw*08:01, or HLA-DRB1*16:02 serotypes ... Nevirapine: Africans, Asians, and Europeans expressing HLA-DRB1:01:01 or HLA-DRB1:01:02, or HLA-Cw4 serotypes, Asians ...
March 2009). "An extensive screen of the HLA region reveals an independent association of HLA class I and class II with ... Pan HF, Wu GC, Li WP, Li XP, Ye DQ (February 2009). "High Mobility Group Box 1: a potential therapeutic target for systemic ... That leads to maturation of DCs and also to the presentation of intracellular antigens of late apoptotic or secondary necrotic ... HLA class I, class II, and class III genes are associated with SLE, but only classes I and II contribute independently to ...
HLA-A, HLA-B, HLA-C, HLA-DM, HLA-DO, HLA-DP, HLA-DQ, or HLA-DR) can bind to a T-cell receptor and thereby stimulate the ... Individuals expressing certain human leukocyte antigen (i.e. HLA) serotypes (i.e. genetic alleles), genetical-based T cell ... and phenytoin-induced SJS is strongly associated with HLA-B*1502 (HLA-B75), an HLA-B serotype of the broader serotype HLA-B15. ... In addition to acting through HLA proteins to bind with a T-cell receptor, a drug or its metabolite may bypass HLA proteins to ...
Mehra sits on the editorial board of HLA (journal) (formerly known as Tissue Antigens) and is a member of the International ... mellitus patients from the Western Caucasian patients by demonstrating that the former showed a pattern of HLA-DR and HLA-DQ ... Later, in India, he studied HLA-linked genes and identified that a subtype of HLA-DR2 carried a unique class II haplotype which ... Besides, he has published a book, The HLA Complex in Biology and Medicine: A Resource Book, and has contributed chapters to ...
"Nomenclature for factors of the HLA system, 2010". Tissue Antigens. 75 (4): 291-455. doi:10.1111/j.1399-0039.2010.01466.x. PMC ... This haplotype can generally be extended from A- to -DQ as A29-Cw16-B44-DR7-DQ2.2: A*2901 : Cw*1601 : B*4403 : DRB1*0701 : DQA1 ... HLA-Cw*16 (Cw*16) is an HLA-C allele-group. The serotype identifies the more common HLA-Cw*16 gene products. This allele group ... 1989). "Three new class I HLA alleles: structure of mRNAs and alternative mechanisms of processing". Immunogenetics. 29 (2): 80 ...
Epitope analysis of HLA-DQ antigens: what does the antibody see?. [Anat R Tambur, Jimmy Rosati, Shirley Roitberg, Denis Glotz, ... Human leukocyte antigen (HLA)-DQ has emerged as the alloantibody most frequently associated with the generation of de novo ... Our data support the need for changing the manner in which HLA-DQ antigens and antibodies are evaluated for organ ... The generation of HLA-DQ de novo DSA was interrogated in 40 transplant recipients who were immunologically naive before their ...
HLA class II histocompatibility antigen, DQ beta 1 chain - P01920 (DQB1_HUMAN) ... MHC class II molecule interacts with HLA_DM, and HLA_DO in B-cells, in order to release CLIP and facilitate the binding of ... In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) ... Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the ...
Downs syndrome and celiac disease: the prevalence of high IgA-antigliadin antibodies and HLA-DR and DQ antigens in trisomy 21. ... HLA-DR and -DQ antigens were also determined in 75 DS patients (20 with high and 55 with normal IgA-AGA levels), and the ... HLA-DQ Antigens/analysis*. *HLA-DQ Antigens/genetics. *HLA-DR Antigens/analysis* ...
HLA class II histocompatibility antigen, DQ [Golgi membrane] HLA class II histocompatibility antigen, DQ [trans-Golgi network ... HLA class II histocompatibility antigen, DQ [trans-Golgi network membrane] HLA class II histocompatibility antigen, DQ [ ... HLA class II histocompatibility antigen, DQ [transport vesicle membrane] HLA class II histocompatibility antigen, DQ [clathrin- ... HLA class II histocompatibility antigen, DQ [endocytic vesicle membrane] HLA class II histocompatibility antigen, DQ [endocytic ...
HLA-DR Antigens and DQ Beta Chain Gene Probing in Insulin Dependent Diabetics of Asian Origin J.A. Fletcher ; J.A. Fletcher ... J.A. Fletcher, C. Mijovic, O. Odugbesan, E. Mackay, A.R. Bradwell, A.H. Barnett; HLA-DR Antigens and DQ Beta Chain Gene Probing ...
... a world leader in HLA DQ antigen research. The focus of the collaboration is to develop and test novel HLA reagents created by ... "In the last years, we have seen a re-emerging role of HLA-DQ in transplantation medicine with increasing evidence that DQ ... This work requires availability of purified HLA-DQ and other HLA class II molecules, maintaining high physiologic accuracy of ... is focusing on understanding the immunogenicity of HLA-DQ antigens and its role in antibody-mediated rejection in solid organ ...
HLA class II histocompatibility antigen, DQ [Golgi membrane] HLA class II histocompatibility antigen, DQ [trans-Golgi network ... HLA class II histocompatibility antigen, DQ [endocytic vesicle membrane] HLA class II histocompatibility antigen, DQ [lysosomal ... HLA class II histocompatibility antigen, DQ [transport vesicle membrane] (Danio rerio) HLA class II histocompatibility antigen ... HLA II alpha chain [transport vesicle membrane] (Homo sapiens) * HLA class II histocompatibility antigen, DQ [transport vesicle ...
HLA class II histocompatibility antigen, DQ [transport vesicle membrane] HLA class II histocompatibility antigen, DQ [plasma ... HLA class II histocompatibility antigen, DQ [Golgi membrane] HLA class II histocompatibility antigen, DQB1*0602 beta chain ... HLA class II histocompatibility antigen, DQ [trans-Golgi network membrane] HLA class II histocompatibility antigen, DQB1*0602 ... HLA class II histocompatibility antigen, DQ [lysosomal membrane] HLA class II histocompatibility antigen, DQB1*0602 beta chain ...
HUMAN LEUKOCYE ANTIGEN (HLA)-DQA AND DQB EPLET MISMATCHES AND DE NOVO DONOR-SPECIFIC ANTI-HLA-DQ ANTIBODY. / Fidler, S.; ... HUMAN LEUKOCYE ANTIGEN (HLA)-DQA AND DQB EPLET MISMATCHES AND DE NOVO DONOR-SPECIFIC ANTI-HLA-DQ ANTIBODY. Nephrology. 2017 Sep ... title = "HUMAN LEUKOCYE ANTIGEN (HLA)-DQA AND DQB EPLET MISMATCHES AND DE NOVO DONOR-SPECIFIC ANTI-HLA-DQ ANTIBODY", ... T1 - HUMAN LEUKOCYE ANTIGEN (HLA)-DQA AND DQB EPLET MISMATCHES AND DE NOVO DONOR-SPECIFIC ANTI-HLA-DQ ANTIBODY ...
They report that genetic variants in STAT4 and HLA-DQ genes confer risk of HBV-HCC. ... Genetic variants in human leukocyte antigen/DP-DQ influence both hepatitis B virus clearance and hepatocellular carcinoma ... Genetic variants in STAT4 and HLA-DQ genes confer risk of hepatitis B virus-related hepatocellular carcinoma. *De-Ke Jiang1. ... and rs9275319 at HLA-DQ, Pmeta = 2.72 × 10−17, OR = 1.49. The risk allele G at rs7574865 was significantly associated with ...
Molecular Biology and Evolution of Blood Group and MHC Antigens in Primates ... Structural analysis of the HLA-DR, -DQ, and -DP alleles on the celiac disease-associated HLA-DR3 (DRw17) haplotype. M F Kagnoff ... The primary association of celiac disease to a given HLA-DQ α/β heterodimer explains the divergent HLA-DR associations observed ... Structural analysis of the HLA-DR, -DQ, and -DP alleles on the celiac disease-associated HLA-DR3 (DRw17) haplotype ...
HLA-DQA, and HLA-DQB gene loci has grown enormously since the last listing in this journal 8 years ago. Crystal structure ... determination of several human and mouse HLA class II alleles, representative of two gene loci in each species, enables a ... The list of alleles in the HLA-DRB, ... HLA-DQ Antigens / chemistry* * HLA-DQ Antigens / genetics* * ... The spectrum of HLA-DQ and HLA-DR alleles, 2006: a listing correlating sequence and structure with function Immunogenetics. ...
The association of specific HLA class I and II alleles with type 1 diabetes among Filipinos. Tissue Antigens59 :452 -469,2002. ... Nepom BS, Schwartz D, Palmer JP, Nepom GT: Transcomplementation of HLA genes in IDDM. HLA-DQα- and β-chains produce hybrid ... HLA DR-DQ Haplotypes and Genotypes and Type 1 Diabetes Risk. Henry Erlich, Ana Maria Valdes, Janelle Noble, Joyce A. Carlson, ... HLA DR-DQ Haplotypes and Genotypes and Type 1 Diabetes Risk. Henry Erlich, Ana Maria Valdes, Janelle Noble, Joyce A. Carlson, ...
Tissue Antigens 56:530-538, 2000. OpenUrlCrossRefPubMedWeb of Science ... Because there are indications that genes in the HLA complex are associated with fetal growth (9), we tested whether HLA-DQ ... Birth weight and HLA-DQ genotype in relation to susceptibility to type 1 diabetes as determined from previous studies (11,12). ... It is probably premature to conclude that there is a causal link between HLA-DQ genes and birth weight, but our results ...
Analysis of DNA sequences from diabetics indicates that alleles of HLA-DQ beta determine … ... to insulin-dependent diabetes mellitus maps to the region of chromosome 6 that contains the highly polymorphic HLA class II ... HLA-D Antigens / genetics* * HLA-DQ Antigens / genetics* * HLA-DR Antigens / genetics ... HLA-DQ beta gene contributes to susceptibility and resistance to insulin-dependent diabetes mellitus Nature. 1987 Oct 15-21;329 ...
Shop a large selection of products and learn more about HLADQ/DR/DP Mouse anti-Human, Janelia Fluor 646, Clone: Bu26, Novus ... HLA class II histocompatibility antigen, DQ(W3) alpha chain, HLA-DCA, HLA-DQA, leucocyte antigen DQA1, leukocyte antigen alpha ... MHC class II HLA-D alpha glycoprotein, MHC class II HLA-DQ-alpha-1, MHC class II surface glycoprotein, MHC HLA-DQ alpha. ... The antibody reacts with DP, DQ, DR beta chains, which are expressed by antigen presenting cells, B- cells, monocytes and ...
HLA-DQ (DQ) is encoded on the HLA region of chromosome 6p21.3, in what was classically known as the "D" antigen region. This ... The DQ loci are in close genetic linkage to HLA-DR, and less closely linked to HLA-DP, HLA-A, HLA-B and HLA-C. ... HLA-DQ (DQ) is a cell surface receptor protein found on antigen presenting cells. It is an αβ heterodimer of type MHC class II ... HLA DQ functions as a cell surface receptor for foreign or self antigens. The immune system surveys antigens for foreign ...
Abbreviations: GSTT1, glutathione S-transferase T1 gene; HLA-DQ, human leukocyte-DQ antigen locus; NAT2, N-acetlytransferase 2 ... HLA-DQ locus of the human leukocyte antigen complex and type 1 diabetes mellitus: A HuGE review. Epidemiologic Reviews 2000; 22 ... In a number of studies the selection of cases has not been well described (35). In a review of type1 diabetes and HLA-DQ ... On estimating HLA/disease association with application to a study of aplastic anemia. Biometrics 1991;47:53-61. ...
This study aimed to validate and detect new HLA-DR and DQ associations with LS in female … ... Several small studies, using serological typing, have reported that HLA-DR11, DR12, and DQ7 were increased in LS, with DR17 ... The association between HLA DR, DQ antigens, and vulval lichen sclerosus in the UK: HLA DRB112 and its associated DRB112/ ... The association between HLA DR, DQ antigens, and vulval lichen sclerosus in the UK: HLA DRB112 and its associated DRB112/ ...
HLA)-A, B (class I) and HLA-DR, DQ (class II) antigens and to assess the frequency of the presence of these antigens in the ... HLA-A, B (Class I) and HLA-DR, DQ (Class II) antigens in Turkish patients with recurrent aphthous ulceration and Behçets ... A decrease was observed in HLA-DR10 and HLA-DR17 in the RAU patients (p , 0.05), while a higher frequency of HLA-DR10 was ... HLA typing was performed by serology with commercial kits for HLA class I and II (One Lambda, Canoga Park, Calif., USA). ...
Serra, HM, Crimi, C, Sette, A & Celis, E 1993, Fine restriction analysis and inhibition of antigen recognition in HLADQ‐ ... Fingerprint Dive into the research topics of Fine restriction analysis and inhibition of antigen recognition in HLADQ‐ ... T1 - Fine restriction analysis and inhibition of antigen recognition in HLADQ‐restricted T cells by major histocompatibility ... Fine restriction analysis and inhibition of antigen recognition in HLADQ‐restricted T cells by major histocompatibility ...
Antigen Expression CD19 +; CD20 +; CD21 +; CD22 +; Hle-1 +; HLA DQ +; HLA DR +; CD25 -; T cell receptor (TCR) - ...
... and less closely linked to HLA-DP, HLA-A, HLA-B and HLA-C. Different isoforms of DQ can bind to and present different antigens ... HLA-DQ (DQ) is encoded on the HLA region of chromosome 6p21.3, in what was classically known as the "D" antigen region. This ... HLA-DQ (DQ) is a cell surface receptor protein found on antigen-presenting cells. It is an αβ heterodimer of type MHC class II ... HLA DQ functions as a cell surface receptor for foreign or self antigens. The immune system surveys antigens for foreign ...
HLA class II histocompatibility antigen, DQ alpha 1 chain 9606 138 5KSB 1 A, C HLA class II histocompatibility antigen, DQ ... HLA class II histocompatibility antigen, DQ alpha 1 chain 9606 92 4E41 1 A, F HLA class II histocompatibility antigen, DR alpha ... HLA class II histocompatibility antigen, DQ alpha 1 chain 9606 15 3PDO 1 A HLA class II histocompatibility antigen, DR alpha ... HLA class II histocompatibility antigen, DQ alpha 1 chain 9606 19 1KLU 1 A HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DR ALPHA ...
HLA class II histocompatibility antigen, DQ beta 1 chain. Source:. NCBIAccessed: 16 March, 2017. ... The genotype of HLA-A, HLA-B, HLA-DR, and HLA-DQ alleles was typed by means of PCR sequence-specific priming.. RESULTS: HLA-B* ... the most common HLA class I and II antigens expressed were HLA-A*02 (49·1% and 28·6%), HLA-B*07 (21·3% and 11·1%), HLA-C*07 (46 ... HLA-DRB1, HLA-DPA1, HLA-B, HLA-DMA and HLA-DRA, and the immune response. Allograft rejection was selected as the most ...
Mouse Monoclonal Anti-HLA DQ Antibody (TAL 4.1) [Janelia Fluor® 646]. Validated: Flow, IHC. Tested Reactivity: Human. 100% ... HLA class II histocompatibility antigen, DQ(W3) alpha chain. *HLA-DCA. *HLA-DQA ... Home » HLA DQ » HLA DQ Antibodies » HLA DQ Antibody (TAL 4.1) [Janelia Fluor® 646] ... Reviews for HLA DQ Antibody (NB100-2700JF646) (0) There are no reviews for HLA DQ Antibody (NB100-2700JF646). By submitting a ...
Mouse Monoclonal Anti-HLA DQ/DR/DP Antibody (WR18) [DyLight 650]. Validated: Flow, IHC, IHC-P. Tested Reactivity: Human. 100% ... Recognizes HLA Class II beta chains of human major histocompatability antigen, Mw 28 kD. It reacts with a monomorphic ... Home » HLA DQ/DR/DP » HLA DQ/DR/DP Antibodies » HLA DQ/DR/DP Antibody (WR18) [DyLight 650] ... Blogs on HLA DQ/DR/DP. There are no specific blogs for HLA DQ/DR/DP, but you can read our latest blog posts. ...
We studied the relationship between maternal-fetal HLA disparity and IBD course. METHODS: Women with IBD and childbirth wer ... 0/HLA-DQ Antigens; 0/HLA-DR Antigens; 128338-86-3/HLA-DRB1 antigen ... HLA-DQ Antigens / analysis*. HLA-DR Antigens / analysis*. Humans. Pregnancy. Pregnancy Complications / immunology*, ... Each mother/child pair was assigned an HLA disparity status (+/-) for HLA A, B, C, DRB1, and DQ loci. Odds ratios were ...
0 (FABP2 protein, human); 0 (Fatty Acid-Binding Proteins); 0 (HLA-DQ Antigens); 0 (HLA-DQ2 antigen); 0 (HLA-DQ8 antigen); 0 ( ... Ant genos HLA-DQ/sangue. Seres Humanos. Imunoglobulina A/imunologia. Lactente. Mucosa Intestinal/patologia. Masculino. ... Luo YD; Zhang QL; Yao SJ; Lin DQ. [Ad] Endere o:. Key Laboratory of Biomass Chemical Engineering of Ministry of Education, ... In the current study, we assessed serum IgA binding to the B. burgdorferi peptide antigens, C6, the target of the FDA-cleared ...
0/Biological Markers; 0/HLA-DQ Antigens; 0/HLA-DQ2 antigen; 0/HLA-DQ8 antigen; 8002-80-0/Glutens ... HLA-DQ Antigens / blood. Humans. Likelihood Functions. Male. Models, Theoretical. Retrospective Studies. ... Those with equivocal serology should undergo HLA typing to determine the need for biopsy.. ... HLA) DQ2/DQ8 testing.. RESULTS: Of the 238 study subjects, 101 had CD, 125 had NCGS, 9 had non-celiac enteropathy, and 3 had ...
  • A disparity between antigen density and mean fluorescence intensity values for some alleles within an eplet group was noted, with mean fluorescence intensity values of the lowest fluorescence bead being one tenth of the highest fluorescence bead, despite the fact that the amount of antigen on these beads were not significantly different. (sigmaaldrich.com)
  • Our panel of highly representative HLA-DQ alleles will help to drive novel research to prevent transplant rejection and to contribute to more insight into DSA responses and we are thrilled to be working with Dr. Tambur, a world leader in this field. (californianewswire.com)
  • The list of alleles in the HLA-DRB, HLA-DQA, and HLA-DQB gene loci has grown enormously since the last listing in this journal 8 years ago. (nih.gov)
  • Crystal structure determination of several human and mouse HLA class II alleles, representative of two gene loci in each species, enables a direct comparison of ortholog and paralog loci. (nih.gov)
  • The major genetic determinants of type 1 diabetes are alleles at the HLA-DRB1 and DQB1 loci, with both susceptible and protective DR-DQ haplotypes present in all human populations. (diabetesjournals.org)
  • The most important genetic contribution to the risk of type 1 diabetes is encoded within the HLA complex on chromosome 6p ( 4 ), and different HLA-DQA1 and -DQB1 alleles confer either strongly increased or reduced risk ( 5 ). (diabetesjournals.org)
  • Analysis of DNA sequences from diabetics indicates that alleles of HLA-DQ beta determine both disease susceptibility and resistance, and that the structure of the DQ molecule, in particular residue 57 of the beta-chain, specifies the autoimmune response against the insulin-producing islet cells. (nih.gov)
  • Serotyping is capable of identifying most aspects of DQ isoform structure and function, however sequence specific PCR is now the preferred method of determining HLA-DQA1 and HLA-DQB1 alleles , as serotyping cannot resolve, often, the critical contribution of the DQ α-chain. (wikipedia.org)
  • Recognize HLA-DQB1*02 gene products which include gene products of the following alleles: HLA-DQB1*02:01 HLA-DQB1*02:02 HLA-DQB1*02:03 Sometimes DQ2 antibodies recognize other gene products, such as DQB1*03:03, resulting in serotyping errors. (wikipedia.org)
  • Susceptibility to human papillomavirus-associated cervical intra-epithelial neoplasia is determined by specific HLA DR-DQ alleles. (semanticscholar.org)
  • DQ4 β-chains combine with α-chains, encoded by genetically linked HLA-DQA1 alleles, to form the cis-haplotype isoforms. (wikipedia.org)
  • HLA-DQ alleles and susceptibility to celiac disease in Spanish children. (nih.gov)
  • Human leukocyte antigen alleles and haplotypes associated with selective immunoglobulin A deficiency in Spanish pediatric patients. (nih.gov)
  • Restriction fragment length polymorphism analysis of HLA-DR- and DQ-linked alleles in multiple sclerosis in Spain. (nih.gov)
  • Data from HLA-DR2(B1*1501), -DR3(B1*0301), -DQ2(A1*0501, B1*0201), and -DQ8(A1*0301, B1*0302) alleles were used by a computer program that searches a candidate protein to predict ligands with a relatively high probability of being processed and presented. (jimmunol.org)
  • When the information from the nonbinding N- and C-terminal regions in the pool sequence was removed, the ability to predict several ligands was markedly reduced, particularly for the HLA-DQ alleles. (jimmunol.org)
  • Extended' haplotypes were reconstructed: the three most frequent haplotypes (covering a total frequency of 11.5%) share the same Cw, B, DR and DQ alleles. (skadi.net)
  • Researchers have identified hundreds of different versions (alleles) of the HLA-DQA1 gene, each of which is given a particular number (such as HLA-DQA1*05:01 ). (medlineplus.gov)
  • Different human leukocyte antigen (HLA) class II alleles have been associated with the development of atopic asthma and responsiveness of allergen exposure. (lww.com)
  • HLA-DR and -DQ alleles were typed using the Dynal AllSet+™ "low resolution" SSP kit. (lww.com)
  • 30% of northern European Caucasians carry the HLA DQA1 and DQB1 alleles that encode the expressed HLA DQ2 molecule, BUT only ____% of these develop coeliac disease. (brainscape.com)
  • Yet most HLA-associated diseases (which include infectious diseases and some forms of cancer) do not reveal a simple Mendelian mode of inheritance, either recessive or dominant, are only partially penetrant, and may involve a number of different HLA alleles in addition to non-HLA loci (3). (springer.com)
  • The aim of this retrospective study was to determine the impact of these two alleles for LTx recipients on anti-HLA alloimmunization risk, overall survival, and chronic rejection (CLAD). (hindawi.com)
  • This retrospective study shows an uninvestigated, deleterious association of HLA-E alleles with LTx and requires verification using a larger cohort. (hindawi.com)
  • The two other alleles were HLA.DRB4*01 at 35.7% and HLA-DQB1*0501 at 28.6%, as detected in each of the clinical and radiological manifestations. (scielo.org.co)
  • The alleles HLA-B27, HLA-DRB4*01 and HLA-DQB1*0501 were common in the different subtypes of spondyloarthritis and were frequent in the specific clinical axial, peripheral and extraarticular clinical manifestations, as well as radiological sacroiliitis. (scielo.org.co)
  • for example, there appear to be 300+ alleles in the HLA-B or DRB1 loci. (bio-medicine.org)
  • Several probes could be used to identify an array of HLA alleles. (bio-medicine.org)
  • By constructing an array of PCR primers complementary to the range of HLA polymorphisms, it is possible to detect the HLA alleles directly by PCR. (bio-medicine.org)
  • An analysis of all possible combinations at DQ has shown that the entire effect was due to heterozygotes expressing the DQ1 and DQ2 alleles. (sciencemag.org)
  • To aid in the search for additional type 1 diabetes genes within and outside the HLA region, an international collaboration (the Type 1 Diabetes Genetics Consortium) has collected and is continuing to collect a large number of type 1 diabetic families (multiplex and simplex) from various populations ( 20 ). (diabetesjournals.org)
  • We found that HLA genotypes previously shown to confer risk for type 1 diabetes were associated with reduced birth weight (the mean difference in birth weight between the DQB1*0602/DQB1*0602 and DQ8/DQ2 genotypes was 354 g [95% CI 105-604]), which was opposite of that expected if HLA genes explained the birth weight-type 1 diabetes association. (diabetesjournals.org)
  • Genes in the HLA complex encode molecules involved in rejection of nonself tissue, and antibodies to fetal HLA molecules have been found in a large proportion of parous women ( 8 ). (diabetesjournals.org)
  • Because there are indications that genes in the HLA complex are associated with fetal growth ( 9 ), we tested whether HLA-DQ genotypes previously found to confer risk for type 1 diabetes were associated with increased birth weight among Norwegian children randomly selected from the official population registry. (diabetesjournals.org)
  • Over half of the inherited predisposition to insulin-dependent diabetes mellitus maps to the region of chromosome 6 that contains the highly polymorphic HLA class II genes which determine immune responsiveness. (nih.gov)
  • The variants are encoded by the HLA DQ genes and are the result of single nucleotide polymorphisms (SNP). (wikipedia.org)
  • The major histocompatibility complex (MHC) class I (A, B, and C) and II (DP, DM, DOA, DOB, DQ, and DR) in the human leukocyte antigen (HLA) system contains a large number of genes involved in immune system function in humans. (loinc.org)
  • The proteins encoded by some genes form antigens. (loinc.org)
  • The frequencies of HLA-DRB1*11 and HLA-DRB3* were also significantly increased in TTP patients as compared with controls [44.0% vs. 12.0% (P=0.0024) and 84.0% vs. 58.0% (P=0.024)], although it remains uncertain whether susceptibility is influenced by HLA-DQ or HLA-DR molecules or other genes in this haplotype. (biomedsearch.com)
  • Human leukocyte antigens (HLAs) are an inherent system of alloantigens, which are the products of genes of the major histocompatibility complex (MHC). (cdc.gov)
  • These genes span a region of approximately 4 centimorgans on the short arm of human chromosome 6 at band p 21.3 and encode the HLA class I and class II antigens, which play a central role in cell-to-cell interaction in the immune system. (cdc.gov)
  • Class I human histocompatibility (HLA) antigens encoded by a small cluster of structural genes at the C locus on chromosome 6. (curehunter.com)
  • The HLA-DQA1 gene is part of a family of genes called the human leukocyte antigen (HLA) complex. (medlineplus.gov)
  • The HLA-DQA1 gene belongs to a group of MHC genes called MHC class II. (medlineplus.gov)
  • Combinations of variations in the HLA-DQA1 gene and other HLA genes affect the risk of type 1 diabetes. (medlineplus.gov)
  • Type 1 diabetes risk is most increased by two HLA haplotypes involving variations of the HLA-DQA1 and HLA-DQB1 genes and another HLA gene called HLA-DRB1 . (medlineplus.gov)
  • In humans, highly polymorphic genes on CHROMOSOME 6 encode the alpha subunits of class I antigens and play an important role in determining the serological specificity of the surface antigen. (fpnotebook.com)
  • The best known genes in the MHC region are the subset that encodes cell-surface antigen-presenting proteins. (acris-antibodies.com)
  • In humans, these genes are referred to as human leukocyte antigen (HLA) genes. (acris-antibodies.com)
  • The A, B, and C genes belong to HLA class I while the six D genes belong to class II. (acris-antibodies.com)
  • However, the relationship between the atopic disease in early childhood and HLA-DR and -DQ genes remains unclear. (lww.com)
  • Our aim is to determine the association between HLA-DR and -DQ genes and susceptibility to atopy in a birth cohort at one year follow-up. (lww.com)
  • No association was found between cIgE and HLA-DR and -DQ genes or atopic symptoms. (lww.com)
  • Sollid, L.M. & Thorsby, E. HLA susceptibility genes in celiac disease: genetic mapping and role in pathogenesis. (nature.com)
  • Most people who have narcolepsy with cataplexy have the HLA-DQB1*06:02 variation, and many also have specific versions of other, closely related HLA genes (including HLA-DQA1 ). (medlineplus.gov)
  • However, these variations are very common in the general population, and only a small percentage of people with particular variations in HLA genes develop narcolepsy. (medlineplus.gov)
  • The HLA group of genes have a very significant role in an individual's risk of coeliac disease. (brainscape.com)
  • HLA genes encode DQ molecules. (brainscape.com)
  • There was an enrichment of genes involved in antigen presentation among the AMD-associated genes ( P = 0.0029). (arvojournals.org)
  • Ultimately, disease association with genetic factors has often been defined in terms of human leukocyte antigens (HLA), particularly those for the highly polymorphic class I and class II genes. (springer.com)
  • Genomic wide association studies have confirmed the HLA (human leukocyte antigen) class II genes as the strongest risk factor for predisposition to RA.Using transgenic mice expressing RA-associated and resistant HLA genes, we have developed a collagen-induced arthritis (CIA) model that shares similarities with human disease in sex-bias, autoantibody profile and phenotype.Studies in animal models underscore the impact of the gut flora in extra-intestinal diseases. (nih.gov)
  • Genomic wide association studies have confirmed the HLA (human leukocyte antigen) class II genes as the strongest risk factor for predisposition to RA. (nih.gov)
  • Using transgenic mice expressing RA-associated and resistant HLA genes, we have developed a collagen-induced arthritis (CIA) model that shares similarities with human disease in sex-bias, autoantibody profile and phenotype. (nih.gov)
  • However, the global distribution of HLA-B27 varies considerably and furthermore, associations with non-HLA-B27 genes have been described. (scielo.org.co)
  • The Human Leukocyte Antigen (HLA) region, located on the short arm of chromosome 6 (6p21.3), is a highly polymorphic region containing about 200 genes. (bio-medicine.org)
  • The HLA region is the human equivalent of the Major Histocompatibility Complex (MHC), and as such contains a set of genes that serve as the backbone of antigen presentation. (bio-medicine.org)
  • The Class I proteins, classically involved in presenting endogenous antigens to CD8+ T-cells, are expressed by genes located in the HLA-A, -B and C loci. (bio-medicine.org)
  • Among the most potent genes are those in the HLA or human leukocyte antigen region, which regulate the immune system and help immune cells differentiate self from non-self. (news-medical.net)
  • Together, the genes in the HLA region account for as much as 40 percent of the familial risk of developing type1 diabetes. (news-medical.net)
  • 1. HLA-DQ genes of heterozygous individual which express 4 distinct DQ molecules , why in serological typing can define only 2 DQ antigens? (bio.net)
  • The recent findings on the involvement of HLA class I genes in CD susceptibility are also discussed. (els.net)
  • Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. (rcsb.org)
  • To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. (rcsb.org)
  • HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. (rcsb.org)
  • In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. (rcsb.org)
  • Lysosomal microenvironment has been implicated in the regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and efficient peptide loading. (rcsb.org)
  • 3 MHC class II molecules bind to a CD74 homotrimer (also known as invariant chain or HLA class II histocompatibility antigen gamma chain). (rcsb.org)
  • This work requires availability of purified HLA-DQ and other HLA class II molecules, maintaining high physiologic accuracy of the three-dimensional structure. (californianewswire.com)
  • The results indicate that peptides known to associate with DQ molecules are capable of blocking the presentation of antigen to the DQ‐restricted Tcell clone, presumably by competing with antigen for binding to major histocompatibility complex (MHC) molecules. (elsevier.com)
  • In humans, MHC class II molecules are encoded by three different loci, HLA-DR, -DQ, and -DP, which display 70% similarity to each other. (miltenyibiotec.com)
  • Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). (cancerindex.org)
  • Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to four different molecules. (cancerindex.org)
  • This suggests a possible role for these regions in determining ligands for HLA class II molecules. (jimmunol.org)
  • HLA molecules bind short peptides in an extended configuration along a groove on the surface of the protein, and using new methods including the sequencing of these naturally processed peptide ligands and in vitro binding assays, simple rules can be worked out for the binding motif of a particular HLA molecule ( 6 ). (jimmunol.org)
  • ab23901 recognises the common b unit of HLA-Class 2 molecules. (abcam.com)
  • HLA class II molecules were found in neonates' immune system. (lww.com)
  • Watts, C. Capture and processing of exogenous antigens for presentation on MHC molecules. (nature.com)
  • To assess directly the relative roles of HLA-DQ8 and DR4 for diabetes development in vivo, we generated C57BL/6 transgenic mice that lack endogenous mouse MHC class II molecules but express HLA-DQ8 and/or DR4. (jci.org)
  • A key function of MHC molecules is to present antigens (Ag's) to T cells. (jci.org)
  • These DQ molecules present short antigenic peptides (13-21 aa) to T cells. (brainscape.com)
  • Biochemical characterization of a second family of human la molecules, HLA-DS, equivalent to murine I-A subregion molecules. (springer.com)
  • In conjunction with the CD3/TCR complex and CD4 molecules, HLA-DR is critical for efficient peptide presentation to CD4 + T cells. (biolegend.com)
  • The L243 monoclonal antibody reacts with the HLA-DR antigen, a member of MHC class II molecules. (biolegend.com)
  • HLA-DQ8 and DRB1FNx010401 molecules predispose to develop arthritis while DRB1FNx010402 provides protection. (nih.gov)
  • There is strong evidence that CD is the result of aberrant T cell responses to gluten peptides bound to the disease predisposing Human Leukocyte Antigen (HLA-DQ) molecules. (europa.eu)
  • Recent evidences also highlighted how adaptive CD8+ T lymphocytes restricted by HLA class I molecules contribute to the enterocytes damage through a TCR‐dependent cytotoxic activity. (els.net)
  • Several gluten peptides (as p123-132) are able to bind to HLA‐class I molecules (in particular to HLA‐A1, A2 and B8) expressed on the surface of both dendritic cells and epithelial cells, and are specifically recognised by CD8+TCRαβ+ in the lamina propria. (els.net)
  • While the DQ3 molecules are structurally similar in beta chain, the DQ molecules differ markedly in function, even when present with the same DQ alpha subunit. (wikipedia.org)
  • Bacterial SAgs possess the unique ability to cross-link major histocompatibility complex (MHC) class II molecules and T-cell receptors, which in turn is responsible for their ability to illicit an immune response several orders of magnitude greater than that of conventional peptide antigens. (asmscience.org)
  • Conventional antigens are processed internally by antigen-presenting cells (APCs) and displayed as discrete peptides on the cell surface by MHC class II molecules. (asmscience.org)
  • Crystal structures of SAgs in complex with MHC class II molecules via both the generic site (SEB and TSST-1 in complex with HLA-DR1) and the high-affinity site SpeC in complex with HLA-DR2 and SEH in complex with HLA-DR1 have allowed a detailed examination of these interactions. (asmscience.org)
  • However, allelic variation at these loci cannot account fully for the pattern of HLA haplotype sharing among affected sibpairs ( 8 ). (diabetesjournals.org)
  • Moreover, the association analysis of other HLA loci (class I and DPB1) and other polymorphisms within the HLA region has revealed the presence of additional type 1 diabetes susceptibility loci in this region ( 9 - 19 ). (diabetesjournals.org)
  • The α and β chains are encoded by two loci , HLA-DQA1 and HLA-DQB1 , that are adjacent to each other on chromosome band 6p21.3 . (wikipedia.org)
  • The DQ loci are in close genetic linkage to HLA-DR , and less closely linked to HLA-DP , HLA-A , HLA-B and HLA-C . (wikipedia.org)
  • Each mother/child pair was assigned an HLA disparity status (+/-) for HLA A, B, C, DRB1, and DQ loci. (biomedsearch.com)
  • DQ4.24 is also high in the Swedes however this may be due to east to west gene flow tracable at other HLA loci. (wikipedia.org)
  • HLA-DR, -DP, -DQ genetic loci determine class II antigens. (cdc.gov)
  • In this study, 58 non-DR15 patients with narcolepsy-cataplexy were typed at the HLA DRB1, DQA1 and DQB1 loci. (semanticscholar.org)
  • In contrast, the Class II proteins, which associate with and present exogenous antigens to CD4+ T-cells, are expressed by the HLA DR, -DQ and DP loci. (bio-medicine.org)
  • However, the advent of recombinant DNA technology, which paved the way to identifying genetic differences among the HLA loci directly, has led many laboratories to abandon classic serological typing methods. (bio-medicine.org)
  • In general, HLA DNA can be typed either by hybridizing labeled, sequence specific oligonucleotide probes to HLA loci amplified by the polymerase chain reaction (PCR), or by using PCR to amplify th e HLA DNA directly through differential primer extension. (bio-medicine.org)
  • for example, it is possible to construct PCR primers pre labeled with biotin, and then amplify biotin labeled HLA loci. (bio-medicine.org)
  • For those laboratories with access to Sequencers, it may be the most sensitive, specific and cost effective option to sequence certain HLA loci directly. (bio-medicine.org)
  • Our data support the need for changing the manner in which HLA-DQ antigens and antibodies are evaluated for organ transplantation. (sigmaaldrich.com)
  • Down's syndrome and celiac disease: the prevalence of high IgA-antigliadin antibodies and HLA-DR and DQ antigens in trisomy 21. (nih.gov)
  • Increasing evidence has demonstrated that DQ mismatches between transplant recipient and donor are the most common to induce de novo donor-specific antibodies (DSA). (californianewswire.com)
  • HLA-DQ antibodies are likely also the most detrimental to graft survival. (californianewswire.com)
  • Serological studies of DQ recognized that antibodies to DQ bind primarily to the β-chain. (wikipedia.org)
  • Antibodies raised against DQ tend to recognize these functional regions, in most cases the β-subunit. (wikipedia.org)
  • As a result, these antibodies can discriminate different classes of DQ based on the recognition similar DQβ proteins known as serotypes. (wikipedia.org)
  • IgG antibodies to HLA Class II (HLA-DP+DQ+DR) glycoproteins are detected in patient's serum or plasma by EIA methods. (loinc.org)
  • Antibodies specific to HLA class I and II antigens can be acquired through alloimmunization due to pregnancy, transfusion of blood products, or previous transplants. (loinc.org)
  • Various testing methods are used to detect antibodies to HLA antigens. (loinc.org)
  • Renal retransplantation in patients with HLA-antibodies. (booktopia.com.au)
  • In addition, numerous 3D structures of antibodies in complex with their target antigen have been reported and have permitted statistical identification of residues that are in direct contact with the antigen or that affect the binding affinity ( 4 - 7 ). (frontiersin.org)
  • Antibodies to β-cell autoantigens (islet cell antibodies, insulin autoantibodies, GAD antibodies, and antibodies to the islet antigen 2 molecule) and HLA genotypes were analyzed. (diabetesjournals.org)
  • 34 (68%) were mismatched at the DQ locus. (biomedsearch.com)
  • The β-chain of DQ is encoded by HLA-DQB1 locus and DQ4 are encoded by the HLA-DQB1*04 allele group. (wikipedia.org)
  • The length of the haplotype is remarkable because of the rapid rate of evolution at the HLA locus should degrade such long haplotypes. (wikipedia.org)
  • A group of the D-related HLA antigens (human) found to differ from the DR antigens in genetic locus and therefore inheritance. (curehunter.com)
  • Das erste HLA Merkmal (HLA = human /eukocyte antigen, locus A) wurde 1958 von Dausset [20] beschrieben, wofür er 1980 den Medizin-Nobelpreis erhielt. (springer.com)
  • One of the most commonly employed strategies in HLA DNA typing is to first amplify a given HLA locus, then hybridize it with a labeled, sequence specific oligonucleotide probe. (bio-medicine.org)
  • The human leukocyte antigen (HLA) locus DQ is related to the primary Sjogren's syndrome autoantibodies that bind the RNA proteins Ro/SSA and La/SSB. (sciencemag.org)
  • Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL , leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). (rcsb.org)
  • Through its new ecommerce website, www.hlaprotein.com, Pure Protein now offers academic and commercial researchers the ability to purchase individual HLA reagents to detect, profile, and monitor allele-specific immune responses, as well as HLA peptide epitope binding services to aide in improving the design of vaccination and therapeutic targeting strategies. (californianewswire.com)
  • Experiments were also done to study the feasibility of peptide blocking of antigen recognition by DQ‐restricted T cells. (elsevier.com)
  • Moreover, truncations of the stimulatory antigenic peptide resulted in the production of Tcell receptor antagonists, which inhibited the response of the T cells to antigen at 10-100‐fold lower concentrations than conventional MHC blockers. (elsevier.com)
  • The role of DQ‐restricted Tcell responses and peptide blocking approaches in autoimmunity are discussed. (elsevier.com)
  • Thus, the use of complete eluted peptide sequence data offers a powerful approach to the prediction of HLA-DQ and -DR peptide ligands and T cell epitopes. (jimmunol.org)
  • Recently, it has been shown that T cell epitopes can be predicted by using the knowledge of the type of peptide ligand that a particular HLA molecule binds ( 4 , 5 ). (jimmunol.org)
  • 11 ). This table was then used by a computer program to predict the likelihood that a particular peptide would be processed from a parent protein and presented by the HLA molecule of interest. (jimmunol.org)
  • The APC processes the antigens, and the immunogenic peptide is then presented at the cell surface along with the MHC molecule for recognition by the TCR. (cdc.gov)
  • A peptide transporter, associated with antigen processing (TAP), plays an important role in maintaining adequate levels of peptide (7) . (cdc.gov)
  • HLA-DQ/peptide tetramer staining, ELI-spot assays and intracellular IFN gamma staining will be exploited to establish the overall frequency of gluten specific T cells in coeliac mucosa and to assess the importance of T cell recognition of deamidated vs. non-deamidated gluten epitopes. (europa.eu)
  • These peptide antigens are then recognized by T-cell receptors (TCRs) specific to that peptide. (asmscience.org)
  • MHC class II molecule interacts with HLA_DM, and HLA_DO in B-cells, in order to release CLIP and facilitate the binding of antigenic peptides. (rcsb.org)
  • Understanding the unique structural and molecular properties that make the HLA-DQ molecule so pathogenic may eventually help us better predict which mismatches will induce harmful antibody formation, and which are more permissible. (californianewswire.com)
  • Furthermore, the program identified ligands from proteins in which the binding motif of the HLA molecule was unable to do so. (jimmunol.org)
  • The MHC molecule provides a context for the recognition of antigens by T lymphocytes. (cdc.gov)
  • DQA encodes the ____2____ chain of the DQ molecule and DQB encodes the ____3____ chain. (brainscape.com)
  • Both chains come together to form the DQ molecule on the cell surface. (brainscape.com)
  • HLA-G is a nonclassical HLA class I molecule, closely related to HLA-E: the HLA-E molecule also plays a crucial role in inflammatory and adaptive immune responses. (hindawi.com)
  • The comparison of closely related DR-DQ haplotype pairs with different type 1 diabetes risks allowed identification of specific amino acid positions critical in determining disease susceptibility. (diabetesjournals.org)
  • The table to the left shows the values of Japanese(values converted from phenotype frequencies to haplotype frequencies for sake of consistency) DR-DQ types. (wikipedia.org)
  • The DR*0405 and DR*410 are found specifically associated with these DQ types and there is some haplotype diversity. (wikipedia.org)
  • In diseases with a strong association with an HLA haplotype, identification of relevant T cell epitopes may allow alteration of the pathologic process. (jimmunol.org)
  • The other haplotype, known as DQ8, is composed of the protein produced from HLA-DQA1 gene variants known as HLA-DQA1*03:01 or HLA-DQA1*03:02 bound to the protein produced from the HLA-DQB1 gene variant known as HLA-DQB1*03:02 . (medlineplus.gov)
  • The familial cases carried the HLA DR4-DQ8 haplotype more frequently than sporadic cases (74.0 vs. 67.0%, P = 0.02). (diabetesjournals.org)
  • The aim of this study is to estimate the risk conferred by specific DR-DQ haplotypes and genotypes. (diabetesjournals.org)
  • The association analysis was performed by comparing the frequency of DR-DQ haplotypes among the chromosomes transmitted to an affected child with the frequency of chromosomes not transmitted to any affected child. (diabetesjournals.org)
  • RESULTS- A number of susceptible, neutral, and protective DR-DQ haplotypes have been identified, and a statistically significant hierarchy of type 1 diabetes risk has been established. (diabetesjournals.org)
  • These data also indicate that the risk associated with specific HLA haplotypes can be influenced by the genotype context and that the trans- complementing heterodimer encoded by DQA1*0501 and DQB1*0302 confers very high risk. (diabetesjournals.org)
  • At least two specific combinations of HLA gene variants (HLA haplotypes) have been found to increase the risk of developing celiac disease, a disorder in which inflammation damages the intestinal tract and other organs and tissues. (medlineplus.gov)
  • One of these haplotypes, known as DQ2, is composed of the protein produced from HLA-DQA1 gene variants known as HLA-DQA1*05:01 or HLA-DQA1*05:05 bound to the protein produced from HLA-DQB1 gene variants known as HLA-DQB1*02:01 or HLA-DQB1*02:02 . (medlineplus.gov)
  • Other HLA haplotypes only mildly increase the risk of type 1 diabetes, while some haplotypes seem to protect against developing this condition. (medlineplus.gov)
  • Which ethnic groups carry high risk DR-DQ haplotypes for type 1 diabetes mellitus (DM)? (medscape.com)
  • Awdeh ZL, Raum D, Yunis EJ, Alper CA (1983) Extended HLA/complement allele haplotypes: evidence for T/t like complex in man. (springer.com)
  • HLA DR-DQ haplotypes and genotypes and type 1 diabetes risk: analysis of the type 1 diabetes genetics consortium families. (medscape.com)
  • 2003) Additional factor in some HLA DR3/DQ2 haplotypes confers a fourfold increased genetic risk of celiac disease. (els.net)
  • CONCLUSION: Analysis identified HLA class II types associated with susceptibility to and a protective effect against the development of acute acquired TTP in European patients. (biomedsearch.com)
  • Various potential markers of susceptibility to RF have been investigated, including blood groups and human leukocyte antigen (HLA) subtypes, but findings have often been inconsistent. (mja.com.au)
  • Genetic investigation regarding allthree patients revealed the existence of HLA DQ A1*0501 allele associated with susceptibility to coeliacdisease. (medscimonit.com)
  • Initially, 37 epitopes derived from six stage-dependent, overexpressed antigens were predicted, which were presented by at least 26 diverse MHC class-II allele. (frontiersin.org)
  • HLA-DQ association and allele competition in Chinese narcolepsy. (semanticscholar.org)
  • HLA-E allele did not affect pathogen infection or the production of de novo DSA. (hindawi.com)
  • The frequency of HLA-B27 was 50% overall, and it was the most frequent allele. (scielo.org.co)
  • HLA-DQ (DQ) is encoded on the HLA region of chromosome 6p 21.3, in what was classically known as the "D" antigen region. (wikipedia.org)
  • The DQ α subunit is encoded by the HLA-DQA1 gene and the DQ β subunit is encoded by the HLA-DQB1 gene. (wikipedia.org)
  • HLA-DQB1 belongs to the HLA class II beta chain paralogs. (cancerindex.org)
  • HLA-DQ4 and HLA-DQB1*04 are almost synonymous in meaning. (wikipedia.org)
  • The protein produced from the HLA-DQA1 gene attaches (binds) to the protein produced from another MHC class II gene, HLA-DQB1 . (medlineplus.gov)
  • 100 IU/ml (Odds Ratio (OR) =5.01, 95% ci= [1.22, 27.14]), and HLA-DQB1*02 (OR = 8.09, 95% CI= [1.91, 36.74]) were risk factors for atopic symptoms in children at one year follow-up. (lww.com)
  • Although, no allergen-specific IgE data were found in infants, we suggest that HLA-DQB1*02 and maternal atopy are important risk factors for atopic symptoms in early stage of childhood. (lww.com)
  • A version of the HLA-DQB1 gene called HLA-DQB1*06:02 increases the risk of developing the sleep disorder narcolepsy, particularly in people who also have cataplexy. (medlineplus.gov)
  • It is unclear how HLA-DQB1*06:02 causes this elevated risk. (medlineplus.gov)
  • It is synonymous with the HLA-DQB1*04 allelegroup. (wikidoc.org)
  • DQB1*0301 the DQ7 gene, is detailed on HLA-DQ7 DQB1*0302 the DQ8 gene, is detailed on HLA-DQ8 DQB1*0303 the DQ9 gene, is detailed on HLA-DQ9 DQB1*0304 is similar in structure and function to DQB1*0301 generally considered to be HLA-DQ7 DQB1*0305 is similar in structure and function to DQB1*0302 generally considered to be HLA-DQ8 Goyert SM, Silver J (1983). (wikipedia.org)
  • The presence in Indonesia may be the result of retrograde gene flow that can be established by other HLA types as well as mtDNA. (wikipedia.org)
  • The HLA-DQA1 gene provides instructions for making a protein that plays a critical role in the immune system. (medlineplus.gov)
  • The HLA complex is the human version of the major histocompatibility complex (MHC), a gene family that occurs in many species. (medlineplus.gov)
  • Certain normal variations of the HLA-DQA1 gene have been associated with increased risk of autoimmune disorders, which occur when the immune system malfunctions and attacks the body's own tissues and organs. (medlineplus.gov)
  • It is unclear how different versions of the HLA-DQA1 gene influence the risk of developing autoimmune disorders. (medlineplus.gov)
  • Moreover, the HLA-DQ gene-dose effect has an impact on the strength of the gluten-specific T-cell response and thus may correlate with clinical presentation and severity of CD. (unboundmedicine.com)
  • No correlation was found between disease severity and a double HLA-DQ2 gene dose. (unboundmedicine.com)
  • Gene variants of DR and DQ in the HLA region are particularly important and are found in 95 percent of type 1 diabetics. (news-medical.net)
  • HLA-DQA1 belongs to the HLA class II alpha chain paralogues. (acris-antibodies.com)
  • Proximity Ligation Analysis (PLA) of protein-protein interactions between CD74 and HLA-DQA1. (acris-antibodies.com)
  • HeLa cells were stained with anti-CD74 rabbit purified polyclonal 1:1200 and anti-HLA-DQA1 mouse monoclonal antibody 1:50. (acris-antibodies.com)
  • Western Blot analysis of HLA-DQA1 expression in transfected 293T cell line ( H00003117-T02 ) by HLA-DQA1 MaxPab polyclonal antibody.Lane 1: HLA-DQA1 transfected lysate(28.00 KDa).Lane 2: Non-transfected lysate. (acris-antibodies.com)
  • Western blot analysis of HLA-DQA1 Antibody (Center) Cat. (acris-antibodies.com)
  • This demonstrates the HLA-DQA1 antibody detected the HLA-DQA1 protein (arrow). (acris-antibodies.com)
  • Flow cytometric analysis of K562 cells using HLA-DQA1 Antibody (Center) Cat. (acris-antibodies.com)
  • Binds peptides derived from antigens that access the endocytic route of antigen presenting cells ( APC ) and presents them on the cell surface for recognition by the CD4 T-cells. (rcsb.org)
  • Analysis of the crystal structure of HLA-DR1 ( 8 ) and HLA-DR3 ( 9 ) has shown them to have binding grooves that are open at each end, allowing longer peptides of variable length to bind. (jimmunol.org)
  • All the eluted ligands are sequenced en masse in a pool after dominant peptides are removed. (jimmunol.org)
  • Using known HLA-restricted T cell epitopes and sequences of eluted ligands, we looked to see whether the program would in fact have predicted that these peptides would be processed and presented from the parent protein. (jimmunol.org)
  • For HLA-DR2(DR15), -DR3(DR17), -DQ2(A1*0501, B1*0201), and -DQ8(A1*0301, B1*0302), we found that the program was highly efficient in predicting these published peptides. (jimmunol.org)
  • Presents peptides from processed endogenous Antigen (e.g. (fpnotebook.com)
  • T cell recognition of many of these peptides is dependant on them being enzymatically modified in a way that promotes their binding to HLA-DQ. (europa.eu)
  • It is possible that oral challenge with pre-deamidated peptides will re-route the peptides into the pathways that normally ensure tolerance to food antigens. (europa.eu)
  • As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. (rcsb.org)
  • Class I antigens restrict cytotoxic T-cell (CD8+) function thus killing viral infected targets, while class II antigens are involved in presentation of exogenous antigens to T-helper cells (CD4+) by antigen presenting cells (APC). (cdc.gov)
  • DQ is made up of two different subunits to form an αβ-heterodimer. (wikipedia.org)
  • Clone REA303 recognizes HLA-DQ, an αβ heterodimer of the MHC class II type. (miltenyibiotec.com)
  • Together, they form a functional protein complex called an antigen-binding DQαβ heterodimer. (medlineplus.gov)
  • Clone L243 binds a conformational epitope on HLA-DRa which depends on the correct folding of the aß heterodimer. (biolegend.com)
  • The current nomenclature system does not reflect the true nature of HLA-DQ polymorphism. (sigmaaldrich.com)
  • Bell JI, Denny DW jr, McDevitt HO (1985) Structure and polymorphism of murine and human class II major hisocompatibility antigens. (springer.com)
  • Recently, we showed that HLA-G genetic polymorphism could be associated with LTx outcome, especially with CLAD occurrence [ 4 ]. (hindawi.com)
  • Here we provide evidence for a new role of this enzyme in the common, HLA-DQ2 (and DQ8) associated6 enteropathy, celiac disease (CD). (nature.com)
  • Cliadin-specific, HLA-DQ(α1*0501,β1*0201) restricted T cells isolated from the small intestinal mucosa of celiac disease patients. (nature.com)
  • A randomized, double-blind, placebo-controlled clinical study in human leukocyte antigen (HLA)-DQ 2.5+ adults with celiac disease (CeD). (clinicaltrials.gov)
  • 2017) Reovirus infection triggers inflammatory responses to dietary antigens and development of celiac disease. (els.net)
  • 2003) Celiac disease association with CD8+ T cell responses: identification of a novel gliadin‐derived HLA‐A2‐restricted epitope. (els.net)
  • Erratum in: Tissue Antigens 1996 May;47(5):455. (nih.gov)
  • Tissue Antigens 61 (4): 308-316. (els.net)
  • The role of polymorphic residues of the β chain of human histocompatibility leukocyte antigen‐DQw5/w6 in antigen presentation to a hepatitis B surface antigen‐specific Tcell clone was studied. (elsevier.com)
  • Both chains of HLA-DQ are polymorphic. (miltenyibiotec.com)
  • These antigens are polymorphic glycoproteins comprising alpha and beta chains and are found on lymphoid and other cells, often associated with certain diseases. (curehunter.com)
  • Found on virtually every cell, MHC (Major Histocompatibility, HLA) Class-I (Antigens) Proteins consist of noncovalently bound polymorphic 44-kDa MHC membrane glycoprotein and nonpolymorphic 12-kDa b2-microglobulin. (fpnotebook.com)
  • The association was the opposite of that expected under the hypothesis that variation in the HLA-DQ genotype explains the previously observed positive association between birth weight and risk of type 1 diabetes ( 1 , 2 ). (diabetesjournals.org)
  • PCR-sequence specific primers method was applied to genotype the HLA-DR, DQ polymorphisms that correspond to 17 serologically defined DR and seven DQ antigens. (cdc.gov)
  • OBJECTIVE To determine the frequency of newly diagnosed diabetic children with first- and second-degree relatives affected by type 1 diabetes and to characterize the effects of this positive family history on clinical markers, signs of β-cell autoimmunity, and HLA genotype in the index case. (diabetesjournals.org)
  • Human leukocyte antigen (HLA)-DQ has emerged as the alloantibody most frequently associated with the generation of de novo donor-specific antibody (DSA), antibody-mediated-rejection, and unfavorable transplantation outcome. (sigmaaldrich.com)
  • The generation of HLA-DQ de novo DSA was interrogated in 40 transplant recipients who were immunologically naive before their failed transplantation. (sigmaaldrich.com)
  • This will pave the way to identifying acceptable mismatches and will allow risk stratification for generating de novo HLA-DSA after transplantation. (sigmaaldrich.com)
  • AUSTIN, Texas, Mar 17, 2021 (SEND2PRESS NEWSWIRE) - Pure Transplant Solutions, LLC (PTS), a collaboration driven biotechnology company focused on the development of human leukocyte antigen (HLA)-based diagnostics and therapeutics within the field of transplantation, is proud to announce that it has entered into a collaboration agreement with Northwestern University, a world leader in HLA DQ antigen research. (californianewswire.com)
  • The Tambur lab at the Comprehensive Transplant Center, Northwestern University, Chicago, is focusing on understanding the immunogenicity of HLA-DQ antigens and its role in antibody-mediated rejection in solid organ transplantation," said Dr. Tambur. (californianewswire.com)
  • In the last years, we have seen a re-emerging role of HLA-DQ in transplantation medicine with increasing evidence that DQ mismatches between transplant recipient and donor are most detrimental to graft survival," said Dr. Buchli. (californianewswire.com)
  • Pure Transplant Solutions, LLC was founded in 1999 in order to leverage the leading research in HLA protein of parent company, Pure Protein, LLC, into solutions to address a growing list of needs in organ transplantation. (californianewswire.com)
  • HLA-E seems to play a major role in the immune response to different viral infections and to affect transplantation outcome, in Hematopoietic Stem Cell Transplantation, for example. (hindawi.com)
  • HLA-E was genotyped in 119 recipients who underwent LTx from 1998 to 2010 in a single transplantation center. (hindawi.com)
  • A clear understanding of the differences between HLA polymorphisms has provided ample insight into why and how foreign tissue is rejected by the host, and as such been a critical enabler of the field of transplantation. (bio-medicine.org)
  • HLA-A, HLA-B, HLA-DRB1 polymorphisms and risk of cervical squamous epithelial cell carcinoma: a population study in China. (semanticscholar.org)
  • For many years HLA polymorphisms were typed by serological respons. (bio-medicine.org)
  • The second HLA DNA typing technique is to use the PCR amplification reaction directly to detect HLA polymorphisms. (bio-medicine.org)
  • Neither HLA-DQ nor HLA-DR transgenic mice developed insulitis or spontaneous diabetes. (jci.org)
  • Ablation of "tolerance" and induction of diabetes by virus infection in viral antigen transgenic mice. (springer.com)
  • HLA-DQ ( DQ ) is a cell surface receptor protein found on antigen presenting cells . (wikipedia.org)
  • As a variable cell surface receptor on immune cells , these D antigens, originally HL-A4 antigens, are involved in graft versus host disease when lymphoid tissues are transplanted between people. (wikipedia.org)
  • HLA DQ functions as a cell surface receptor for foreign or self antigens. (wikipedia.org)
  • Logistic regression identified prepartum disease activity and disparity at both DRB1 and DQ as significant predictors of overall disease activity during pregnancy. (biomedsearch.com)
  • The frequencies of HLA-DRB1*04 and HLA-DRB4 (HLA-DR53) were significantly decreased in the patient group as compared with controls [10.0% vs. 35.0% and 26.0% vs. 61.5% (P=0.0096 and P=0.0024, respectively)], and may have a protective effect against the development of TTP. (biomedsearch.com)
  • Extensive HLA class II studies in 58 non-DRB1*15 (DR2) narcoleptic patients with cataplexy. (semanticscholar.org)
  • Patient must have an available unrelated donor with a 7/8 or 8/8 match for HLA-A, B, C and DRB1 antigen. (clinicaltrials.gov)
  • In the present study, we tested the association between birth weight and HLA-DQ genotypes known to confer risk for type 1 diabetes among 969 nondiabetic children randomly selected from the Norwegian population. (diabetesjournals.org)
  • We decided a priori to categorize HLA-DQ genotypes into five groups according to the degree of risk for type 1 diabetes, as determined in previous studies ( 11 , 12 ). (diabetesjournals.org)
  • The aim of this study was to determine the correlation between HLA-DQ/DR-based genotypes and the variation in phenotypes of the disease. (unboundmedicine.com)
  • The clinical data and HLA genotypes of these patients were compared. (unboundmedicine.com)
  • The risk-associated HLA genotypes have been observed more often in familial type 1 diabetes ( 8 , 20 , 22 , 23 ), although not all studies have found significant differences ( 24 ). (diabetesjournals.org)
  • This region encoded the subunits for DP,-Q and -R which are the major MHC class II antigens in humans. (wikipedia.org)
  • In humans, the entire histocompatibility complex is termed the HLA complex. (cdc.gov)
  • In humans, the HLA is divided into three regions: Class I, II, and III. (acris-antibodies.com)
  • Primary dendritic cells (DCs) also to express HLA-DO. (rcsb.org)
  • The MHC Class II antigens are found on antigen presenting cells (APC) (macrophages, dendritic cells, and B-lymphocytes). (wikipedia.org)
  • All but one revealed an epitope footprint that includes both the DQα and DQβ chains. (sigmaaldrich.com)
  • NB100-64162 recognizes the beta chains of class II human major histocompatibility (MHC) antigens. (fishersci.com)
  • The antibody reacts with DP, DQ, DR beta chains, which are expressed by antigen presenting cells, B- cells, monocytes and activated T lymphocytes. (fishersci.com)
  • Recognizes HLA Class II beta chains of human major histocompatability antigen, Mw 28 kD. (novusbio.com)
  • This antibody reacts with DP, DQ and DR beta chains. (genetex.com)
  • The serotype is determined by the antibody recognition of β4 subset of DQ β-chains. (wikipedia.org)
  • An important prerequisite for antibody humanization requires standardized numbering methods to define precisely complementary determining regions (CDR), frameworks and residues from the light and heavy chains that affect the binding affinity and/or specificity of the antibody-antigen interaction. (frontiersin.org)
  • In addition, the large fluctuation of the variable chain lengths, especially in CDR3 of heavy chains (CDRH3), hardly complicates the comparison and analysis of antibody sequences and the identification of the antigen binding residues. (frontiersin.org)
  • Two autoimmune diseases in which HLA-DQ is involved are coeliac disease and diabetes mellitus type 1 . (wikipedia.org)
  • Coeliac disease (CD) is associated with HLA-DQ2 and DQ8. (unboundmedicine.com)
  • Several small studies, using serological typing, have reported that HLA-DR11, DR12, and DQ7 were increased in LS, with DR17 less frequent. (cdc.gov)
  • The cells express low levels of ICAM-1 HLA class I antigen beta-2-microglobulin. (atcc.org)
  • Our collaboration with Pure Transplant Solutions allows us to develop unique approaches to study the unique involvement of HLA-DQ in transplant immunology. (californianewswire.com)
  • Epitope analysis of HLA-DQ antigens: what does the antibody see? (sigmaaldrich.com)
  • In this investigation, we identified six MHC class-II-restricted epitope hotspots of Leishmania antigens that induce CD4+ Th1 and Th17 responses, which could be used to potentiate a human universal T-epitope vaccine against VL. (frontiersin.org)
  • There was no correlation between the epitope recognized and the presence of particular HLA-DQ antigens. (wikigenes.org)
  • Noble JA, Valdes AM. Genetics of the HLA region in the prediction of type 1 diabetes. (medscape.com)
  • Bodmer W, Thomson G (1977) Population genetics and evolution of the HLA system. (springer.com)
  • A person often produces two α-chain and two β-chain variants and thus 4 isoforms of DQ. (wikipedia.org)
  • Normally, these APC 'present' class II receptor/antigens to a great many T-cells, each with unique T-cell receptor (TCR) variants. (wikipedia.org)
  • A few TCR variants that recognize these DQ/antigen complexes are on CD4 positive (CD4+) T-cells. (wikipedia.org)
  • DQ functions in recognizing and presenting foreign antigens (proteins derived from potential pathogens ). (wikipedia.org)
  • When tolerance to self proteins is lost, DQ may become involved in autoimmune disease . (wikipedia.org)
  • Others result in changes in regions that are removed when the proteins is processed to the cell surface, still others result in change in the non-functional regions of the protein, and some changes result in a change of function of the DQ isoform that is produced. (wikipedia.org)
  • The HLA complex helps the immune system distinguish the body's own proteins from proteins made by foreign invaders such as viruses and bacteria. (medlineplus.gov)
  • 2010) HLA‐DQ2‐restricted gluten‐reactive T cells produce IL‐21 but not IL‐17 or IL‐22. (els.net)
  • Pure Protein, LLC is a biotechnology company funded and managed by Emergent Technologies, Inc. that is focused on the development and commercialization of proprietary technologies related to the human leukocyte antigen (HLA) system, formed and exclusively licensed from the University of Oklahoma. (californianewswire.com)
  • DQ is one of several antigens involved in rejection of organ transplants . (wikipedia.org)
  • 2- 4 DR4, DR8, DR9, and several antigens of the DQ region are related to retinopathy in patients with type 1 diabetes. (bmj.com)
  • The immune system surveys antigens for foreign pathogens when presented by MHC receptors (like HLA DQ). (wikipedia.org)
  • These antigens interact with the antigen-specific cell surface receptors of T lymphocytes (TCR) thus causing activation of the lymphocytes and the resulting immune response. (cdc.gov)
  • A class of white blood cells, the CD8 T lymphocytes, bear receptors specific for the HLA class I antigens and route pathogens such as viruses. (cdc.gov)
  • HLA-E binds preferentially to the inhibitory CD94/NKG2A and activating CD94/NKG2C (which lacks ITIM motif) receptors, selectively expressed on NK cells and a subset of CTL cells, modulating their cell-mediated activity [ 5 ]. (hindawi.com)
  • HLA-A, B (Class I) and HLA-DR, DQ (Class II) antigens in Turkish patients with recurrent aphthous ulceration and Behçet's disease. (cdc.gov)
  • The aims of the present study were to typify the human leukocyte antigen system (HLA)-A, B (class I) and HLA-DR, DQ (class II) antigens and to assess the frequency of the presence of these antigens in the Turkish population with recurrent aphthous ulceration (RAU) and Behçet's disease (BD) compared to healthy subjects. (cdc.gov)
  • HLA disparity determines disease activity through pregnancy in women with inflammatory bowel disease. (biomedsearch.com)
  • Odds ratios were calculated comparing HLA disparity in women whose IBD improved versus those whose disease worsened or remained active. (biomedsearch.com)
  • Moreover, in some infectious diseases ( 4 - 6 ), the host immune reactivity, which is responsible for the pathologic manifestation of disease, has been correlated with HLA specificities. (cdc.gov)
  • in a number of large cohorts, HLA-C mismatches are correlated to an increased risk of acute graft-versus-host disease (GVHD) or even impaired survival. (curehunter.com)
  • The D8/17 non-HLA B-cell antigen has not been studied in Australia, where Aboriginal people have among the world's highest prevalence of rheumatic heart disease (RHD). (mja.com.au)
  • HLA disease associations-Models for the study of complex human genetic disorders. (springer.com)
  • HLA and disease 1982-A survey. (springer.com)
  • The relationship between HLA-A, B, DQ, and DR antigens and asbestos-induced lung disease. (cdc.gov)
  • The association with HLA-B27 remains one of the strongest known links between these entities and the major histocompatibility complex. (scielo.org.co)
  • HLA DQ4 is an HLA-DQ serotype grouping based on antibody recognition of the HLA DQ beta chain. (wikidoc.org)
  • The results obtained demonstrate that the residue situated at position 57 of the β chain (a valine) is critical for presentation of antigen by antigen‐presenting cells to the DQ‐restricted T cell clone. (elsevier.com)
  • Clone REA332 recognizes all major histocompatibility class (MHC) class II HLA-DR, DP, and most DQ antigens. (miltenyibiotec.com)
  • Self antigens, in the right context, form a suppressor T-cell population that protects self tissues from immune attack or autoimmunity. (wikipedia.org)
  • Potential role of molecular mimicry between Helicobacter pylori lipopolysaccharide and host Lewis blood-group antigens in autoimmunity. (springer.com)
  • HLA-DQ4 (DQ4) is a serotype subgroup within HLA-DQ(DQ) serotypes. (wikipedia.org)
  • HLA-DQ3 (DQ3) is a broad serotype category with split antigens HLA-DQ7, DQ8, and DQ9. (wikipedia.org)
  • Historically, originally recognized as MB3 a DC4 serotype, DQw3 was one of three early determined antigens recognized as HLA-DQ along with HLA-DQ1 and HLA-DQ2. (wikipedia.org)
  • But DQ is also involved in recognizing common self-antigens and presenting those antigens to the immune system in order to develop tolerance from a very young age. (wikipedia.org)
  • Furthermore, HLA-E has also been showed to react with CD8 T cells expressing the conventional T Cell Receptor (TCR), suggesting that HLA-E involvement in the adaptive immune system responses is mediated by T cells [ 6 ]. (hindawi.com)
  • Alternatively, macrophages and other megalocytes consume cells by apoptotic signaling and present self-antigens. (wikipedia.org)
  • The data demonstrate the existence of a novel subset of antigen-presenting cells expressing self-antigens in human lymphoid organs that appear to be involved in the regulation of self-tolerance throughout life. (springer.com)
  • Human leukocyte antigen association in idiopathic thrombotic thrombocytopenic purpura: evidence for an immunogenetic link. (biomedsearch.com)
  • OBJECTIVES AND METHODS: DNA was used for human leukocyte antigen (HLA) class II typing, using polymerase chain reaction (PCR)-sequence-specific primer and PCR-sequence-specific oligonucleotide probe to methodology to investigate 50 European acquired idiopathic TTP cases. (biomedsearch.com)
  • Based on a population coverage analysis and human leukocyte antigen cross-presentation ability, six of the 37 epitopes were selected for further analysis. (frontiersin.org)
  • The Past, Present and Future of HLA Typing ( The Human Leukocyte Antigen (HLA) regi. (bio-medicine.org)
  • The Human Leukocyte Antigen (HLA) region located on the short arm. (bio-medicine.org)
  • There is increasing evidence for a protective role of Human-Leukocyte-Antigen (HLA)-DQ in response to infection. (biomedcentral.com)
  • Human leukocyte antigens (HLA) are important in the regulation of immune response to foreign antigens. (semanticscholar.org)
  • They have significantly lower immunogenicity than the HLA-A and -B determinants and are therefore of minor importance in donor/recipient crossmatching. (curehunter.com)
  • The focus of the collaboration is to develop and test novel HLA reagents created by PTS that may be used for enhanced analysis and characterization of DQ antigens, an HLA Class II type that is increasingly gaining importance in causing rejection in transplant patients. (californianewswire.com)
  • Purification of heart-reactive antibody and isolation and characterization of the streptococcal antigen. (springer.com)
  • HLA-DR and -DQ antigens were also determined in 75 DS patients (20 with high and 55 with normal IgA-AGA levels), and the percentages of the different phenotypes were compared in the two groups and with those of a control group. (nih.gov)
  • The frequency of HLA class I and II was determined in a population of patients with spondyloarthritis with respect to detection in the clinical setting and by radiology. (scielo.org.co)
  • A high frequency of HLA-B27 and HLA-DRB4*01 (64.3%) was noted in patients with dactylitis. (scielo.org.co)
  • In conclusion, HLA-DQ expression below normal range may predict prolonged duration of septic shock and increased mortality and could be an indicative marker of immune surveillance in critically ill patients. (biomedcentral.com)
  • To carry out its missionof providing HLA-matched stem cellsfor patients, the NMDP operates aworldwide network of medical organizationsthat cooperate together to locate,procure, and transport stem cellsto waiting patients.The wide range of medical organizationsin the NMDP network areshown in Table 1. (cancernetwork.com)
  • Because HLA antigens areinherited, patients are more likely tofind a matching donor within theirown racial or ethnic communities. (cancernetwork.com)
  • A total of 113 non-related Caucasian children clinically diagnosed with CD during the period 1980-2003 with a known HLA type were included in the study. (unboundmedicine.com)
  • In addition, clinical background factors were considered when studying the frequency of HLA types. (bmj.com)
  • With the exception of a greater frequency of abdominal distension and fewer non-gastrointestinal symptoms in the substantial HLA-risk group, there were no significant differences in clinical characteristics or degree of severity of the small-bowel histological findings between the children in the different HLA-risk groups. (unboundmedicine.com)
  • Class I antigens are found on most nucleated cells and are generally detected by their reactivity with alloantisera. (fpnotebook.com)
  • This has allowed approaching the molecular basis of antigen-antibody interactions. (frontiersin.org)
  • Charron DJ, Lotteau V, Turmel P (1984) Hybrid HLA-DQ antigens: molecular expression. (springer.com)
  • mHLA-II and HLA-DQ median fluorescence intensity (MFI) on monocytes have been monitored daily using flow cytometry. (biomedcentral.com)
  • HLADQ/DR/DP Monoclonal antibody specifically detects HLADQ/DR/DP in Human samples. (fishersci.com)