Hla dq antigens. Medical search

A group of the D-related HLA antigens found to differ from the DR antigens in genetic locus and therefore inheritance. These antigens are polymorphic glycoproteins comprising alpha and beta chains and are found on lymphoid and other cells, often associated with certain diseases.

Antigens determined by leukocyte loci found on chromosome 6, the major histocompatibility loci in humans. They are polypeptides or glycoproteins found on most nucleated cells and platelets, determine tissue types for transplantation, and are associated with certain diseases.

A malabsorption syndrome that is precipitated by the ingestion of foods containing GLUTEN, such as wheat, rye, and barley. It is characterized by INFLAMMATION of the SMALL INTESTINE, loss of MICROVILLI structure, failed INTESTINAL ABSORPTION, and MALNUTRITION.

A subclass of HLA-D antigens that consist of alpha and beta chains. The inheritance of HLA-DR antigens differs from that of the HLA-DQ ANTIGENS and HLA-DP ANTIGENS.

Substances that are recognized by the immune system and induce an immune reaction.

Substances elaborated by bacteria that have antigenic activity.

Proteins, glycoprotein, or lipoprotein moieties on surfaces of tumor cells that are usually identified by monoclonal antibodies. Many of these are of either embryonic or viral origin.

Antigens on surfaces of cells, including infectious or foreign cells or viruses. They are usually protein-containing groups on cell membranes or walls and may be isolated.

Substances elaborated by viruses that have antigenic activity.

Any part or derivative of any protozoan that elicits immunity; malaria (Plasmodium) and trypanosome antigens are presently the most frequently encountered.

Polyomavirus antigens which cause infection and cellular transformation. The large T antigen is necessary for the initiation of viral DNA synthesis, repression of transcription of the early region and is responsible in conjunction with the middle T antigen for the transformation of primary cells. Small T antigen is necessary for the completion of the productive infection cycle.

Large, transmembrane, non-covalently linked glycoproteins (alpha and beta). Both chains can be polymorphic although there is more structural variation in the beta chains. The class II antigens in humans are called HLA-D ANTIGENS and are coded by a gene on chromosome 6. In mice, two genes named IA and IE on chromosome 17 code for the H-2 antigens. The antigens are found on B-lymphocytes, macrophages, epidermal cells, and sperm and are thought to mediate the competence of and cellular cooperation in the immune response. The term IA antigens used to refer only to the proteins encoded by the IA genes in the mouse, but is now used as a generic term for any class II histocompatibility antigen.

Differentiation antigens residing on mammalian leukocytes. CD stands for cluster of differentiation, which refers to groups of monoclonal antibodies that show similar reactivity with certain subpopulations of antigens of a particular lineage or differentiation stage. The subpopulations of antigens are also known by the same CD designation.

Substances of fungal origin that have antigenic activity.

Human immune-response or Class II antigens found mainly, but not exclusively, on B-lymphocytes and produced from genes of the HLA-D locus. They are extremely polymorphic families of glycopeptides, each consisting of two chains, alpha and beta. This group of antigens includes the -DR, -DQ and -DP designations, of which HLA-DR is most studied; some of these glycoproteins are associated with certain diseases, possibly of immune etiology.

Class I human histocompatibility (HLA) surface antigens encoded by more than 30 detectable alleles on locus B of the HLA complex, the most polymorphic of all the HLA specificities. Several of these antigens (e.g., HLA-B27, -B7, -B8) are strongly associated with predisposition to rheumatoid and other autoimmune disorders. Like other class I HLA determinants, they are involved in the cellular immune reactivity of cytolytic T lymphocytes.

The major group of transplantation antigens in the mouse.

Polymorphic class I human histocompatibility (HLA) surface antigens present on almost all nucleated cells. At least 20 antigens have been identified which are encoded by the A locus of multiple alleles on chromosome 6. They serve as targets for T-cell cytolytic responses and are involved with acceptance or rejection of tissue/organ grafts.

Any part or derivative of a helminth that elicits an immune reaction. The most commonly seen helminth antigens are those of the schistosomes.

Membrane glycoproteins consisting of an alpha subunit and a BETA 2-MICROGLOBULIN beta subunit. In humans, highly polymorphic genes on CHROMOSOME 6 encode the alpha subunits of class I antigens and play an important role in determining the serological specificity of the surface antigen. Class I antigens are found on most nucleated cells and are generally detected by their reactivity with alloantisera. These antigens are recognized during GRAFT REJECTION and restrict cell-mediated lysis of virus-infected cells.

A glycoprotein that is secreted into the luminal surface of the epithelia in the gastrointestinal tract. It is found in the feces and pancreaticobiliary secretions and is used to monitor the response to colon cancer treatment.

Sites on an antigen that interact with specific antibodies.

Those proteins recognized by antibodies from serum of animals bearing tumors induced by viruses; these proteins are presumably coded for by the nucleic acids of the same viruses that caused the neoplastic transformation.

Antibodies produced by a single clone of cells.

An HLA-DR antigen which is associated with HLA-DRB1 CHAINS encoded by DRB1*03 alleles.

A group of antigens that includes both the major and minor histocompatibility antigens. The former are genetically determined by the major histocompatibility complex. They determine tissue type for transplantation and cause allograft rejections. The latter are systems of allelic alloantigens that can cause weak transplant rejection.

Molecules on the surface of T-lymphocytes that recognize and combine with antigens. The receptors are non-covalently associated with a complex of several polypeptides collectively called CD3 antigens (ANTIGENS, CD3). Recognition of foreign antigen and the major histocompatibility complex is accomplished by a single heterodimeric antigen-receptor structure, composed of either alpha-beta (RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA) or gamma-delta (RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA) chains.

A specific HLA-A surface antigen subtype. Members of this subtype contain alpha chains that are encoded by the HLA-A*02 allele family.

Identification of the major histocompatibility antigens of transplant DONORS and potential recipients, usually by serological tests. Donor and recipient pairs should be of identical ABO blood group, and in addition should be matched as closely as possible for HISTOCOMPATIBILITY ANTIGENS in order to minimize the likelihood of allograft rejection. (King, Dictionary of Genetics, 4th ed)

Transmembrane proteins that form the beta subunits of the HLA-DQ antigens.

Lymphocytes responsible for cell-mediated immunity. Two types have been identified - cytotoxic (T-LYMPHOCYTES, CYTOTOXIC) and helper T-lymphocytes (T-LYMPHOCYTES, HELPER-INDUCER). They are formed when lymphocytes circulate through the THYMUS GLAND and differentiate to thymocytes. When exposed to an antigen, they divide rapidly and produce large numbers of new T cells sensitized to that antigen.

Nuclear antigen with a role in DNA synthesis, DNA repair, and cell cycle progression. PCNA is required for the coordinated synthesis of both leading and lagging strands at the replication fork during DNA replication. PCNA expression correlates with the proliferation activity of several malignant and non-malignant cell types.

IMMUNOGLOBULINS on the surface of B-LYMPHOCYTES. Their MESSENGER RNA contains an EXON with a membrane spanning sequence, producing immunoglobulins in the form of type I transmembrane proteins as opposed to secreted immunoglobulins (ANTIBODIES) which do not contain the membrane spanning segment.

A glycoprotein that is a kallikrein-like serine proteinase and an esterase, produced by epithelial cells of both normal and malignant prostate tissue. It is an important marker for the diagnosis of prostate cancer.

The lipopolysaccharide-protein somatic antigens, usually from gram-negative bacteria, important in the serological classification of enteric bacilli. The O-specific chains determine the specificity of the O antigens of a given serotype. O antigens are the immunodominant part of the lipopolysaccharide molecule in the intact bacterial cell. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)

Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.

An HLA-DR antigen which is associated with HLA-DRB1 CHAINS encoded by DRB1*04 alleles.

Differentiation antigens found on thymocytes and on cytotoxic and suppressor T-lymphocytes. CD8 antigens are members of the immunoglobulin supergene family and are associative recognition elements in MHC (Major Histocompatibility Complex) Class I-restricted interactions.

A trisaccharide antigen expressed on glycolipids and many cell-surface glycoproteins. In the blood the antigen is found on the surface of NEUTROPHILS; EOSINOPHILS; and MONOCYTES. In addition, CD15 antigen is a stage-specific embryonic antigen.

An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.

Carbohydrate antigens expressed by malignant tissue. They are useful as tumor markers and are measured in the serum by means of a radioimmunoassay employing monoclonal antibodies.

A subtype of HLA-DRB beta chains that includes over one hundred allele variants. The HLA-DRB1 subtype is associated with several of the HLA-DR SEROLOGICAL SUBTYPES.

Serological reactions in which an antiserum against one antigen reacts with a non-identical but closely related antigen.

The major immunoglobulin isotype class in normal human serum. There are several isotype subclasses of IgG, for example, IgG1, IgG2A, and IgG2B.

Morphologic alteration of small B LYMPHOCYTES or T LYMPHOCYTES in culture into large blast-like cells able to synthesize DNA and RNA and to divide mitotically. It is induced by INTERLEUKINS; MITOGENS such as PHYTOHEMAGGLUTININS, and by specific ANTIGENS. It may also occur in vivo as in GRAFT REJECTION.

A group of the D-related HLA antigens (human) found to differ from the DR antigens in genetic locus and therefore inheritance. These antigens are polymorphic glycoproteins comprising alpha and beta chains and are found on lymphoid and other cells, often associated with certain diseases.

The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.

Genetic loci in the vertebrate major histocompatibility complex that encode polymorphic products which control the immune response to specific antigens. The genes are found in the HLA-D region in humans and in the I region in mice.

Complex of at least five membrane-bound polypeptides in mature T-lymphocytes that are non-covalently associated with one another and with the T-cell receptor (RECEPTORS, ANTIGEN, T-CELL). The CD3 complex includes the gamma, delta, epsilon, zeta, and eta chains (subunits). When antigen binds to the T-cell receptor, the CD3 complex transduces the activating signals to the cytoplasm of the T-cell. The CD3 gamma and delta chains (subunits) are separate from and not related to the gamma/delta chains of the T-cell receptor (RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA).

Class I human histocompatibility (HLA) antigens encoded by a small cluster of structural genes at the C locus on chromosome 6. They have significantly lower immunogenicity than the HLA-A and -B determinants and are therefore of minor importance in donor/recipient crossmatching. Their primary role is their high-risk association with certain disease manifestations (e.g., spondylarthritis, psoriasis, multiple myeloma).

Those hepatitis B antigens found on the surface of the Dane particle and on the 20 nm spherical and tubular particles. Several subspecificities of the surface antigen are known. These were formerly called the Australia antigen.

Sets of cell surface antigens located on BLOOD CELLS. They are usually membrane GLYCOPROTEINS or GLYCOLIPIDS that are antigenically distinguished by their carbohydrate moieties.

Transmembrane proteins that form the alpha subunits of the HLA-DQ antigens.

The property of antibodies which enables them to react with some ANTIGENIC DETERMINANTS and not with others. Specificity is dependent on chemical composition, physical forces, and molecular structure at the binding site.

Variant forms of the same gene, occupying the same locus on homologous CHROMOSOMES, and governing the variants in production of the same gene product.

Established cell cultures that have the potential to propagate indefinitely.

55-kDa antigens found on HELPER-INDUCER T-LYMPHOCYTES and on a variety of other immune cell types. CD4 antigens are members of the immunoglobulin supergene family and are implicated as associative recognition elements in MAJOR HISTOCOMPATIBILITY COMPLEX class II-restricted immune responses. On T-lymphocytes they define the helper/inducer subset. CD4 antigens also serve as INTERLEUKIN-15 receptors and bind to the HIV receptors, binding directly to the HIV ENVELOPE PROTEIN GP120.

Lymphoid cells concerned with humoral immunity. They are short-lived cells resembling bursa-derived lymphocytes of birds in their production of immunoglobulin upon appropriate stimulation.

Test for tissue antigen using either a direct method, by conjugation of antibody with fluorescent dye (FLUORESCENT ANTIBODY TECHNIQUE, DIRECT) or an indirect method, by formation of antigen-antibody complex which is then labeled with fluorescein-conjugated anti-immunoglobulin antibody (FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT). The tissue is then examined by fluorescence microscopy.

High-molecular weight glycoproteins uniquely expressed on the surface of LEUKOCYTES and their hemopoietic progenitors. They contain a cytoplasmic protein tyrosine phosphatase activity which plays a role in intracellular signaling from the CELL SURFACE RECEPTORS. The CD45 antigens occur as multiple isoforms that result from alternative mRNA splicing and differential usage of three exons.

The genetic region which contains the loci of genes which determine the structure of the serologically defined (SD) and lymphocyte-defined (LD) TRANSPLANTATION ANTIGENS, genes which control the structure of the IMMUNE RESPONSE-ASSOCIATED ANTIGENS, HUMAN; the IMMUNE RESPONSE GENES which control the ability of an animal to respond immunologically to antigenic stimuli, and genes which determine the structure and/or level of the first four components of complement.

Molecules on the surface of B- and T-lymphocytes that recognize and combine with specific antigens.

Antigens of the virion of the HEPATITIS B VIRUS or the Dane particle, its surface (HEPATITIS B SURFACE ANTIGENS), core (HEPATITIS B CORE ANTIGENS), and other associated antigens, including the HEPATITIS B E ANTIGENS.

The processes triggered by interactions of ANTIBODIES with their ANTIGENS.

Immunized T-lymphocytes which can directly destroy appropriate target cells. These cytotoxic lymphocytes may be generated in vitro in mixed lymphocyte cultures (MLC), in vivo during a graft-versus-host (GVH) reaction, or after immunization with an allograft, tumor cell or virally transformed or chemically modified target cell. The lytic phenomenon is sometimes referred to as cell-mediated lympholysis (CML). These CD8-positive cells are distinct from NATURAL KILLER CELLS and NATURAL KILLER T-CELLS. There are two effector phenotypes: TC1 and TC2.

Deliberate stimulation of the host's immune response. ACTIVE IMMUNIZATION involves administration of ANTIGENS or IMMUNOLOGIC ADJUVANTS. PASSIVE IMMUNIZATION involves administration of IMMUNE SERA or LYMPHOCYTES or their extracts (e.g., transfer factor, immune RNA) or transplantation of immunocompetent cell producing tissue (thymus or bone marrow).

The production of ANTIBODIES by proliferating and differentiated B-LYMPHOCYTES under stimulation by ANTIGENS.

Glycoproteins expressed on cortical thymocytes and on some dendritic cells and B-cells. Their structure is similar to that of MHC Class I and their function has been postulated as similar also. CD1 antigens are highly specific markers for human LANGERHANS CELLS.

Antigens expressed primarily on the membranes of living cells during sequential stages of maturation and differentiation. As immunologic markers they have high organ and tissue specificity and are useful as probes in studies of normal cell development as well as neoplastic transformation.

A specific HLA-B surface antigen subtype. Members of this subtype contain alpha chains that are encoded by the HLA-B*08 allele family.

Serum that contains antibodies. It is obtained from an animal that has been immunized either by ANTIGEN injection or infection with microorganisms containing the antigen.

Immunoglobulins produced in a response to BACTERIAL ANTIGENS.

A specific HLA-B surface antigen subtype. Members of this subtype contain alpha chains that are encoded by the HLA-B*07 allele family.

A specific HLA-B surface antigen subtype. Members of this subtype contain alpha chains that are encoded by the HLA-B*27 allele family.

Genetic loci in the vertebrate major histocompatibility complex which encode polymorphic characteristics not related to immune responsiveness or complement activity, e.g., B loci (chicken), DLA (dog), GPLA (guinea pig), H-2 (mouse), RT-1 (rat), HLA-A, -B, and -C class I genes of man.

Endogenous tissue constituents that have the ability to interact with AUTOANTIBODIES and cause an immune response.

Antigens associated with specific proteins of the human adult T-cell immunodeficiency virus (HIV); also called HTLV-III-associated and lymphadenopathy-associated virus (LAV) antigens.

Class II HLA alleles and hepatitis B virus persistence in African Americans. (1/1046)

Persistence of hepatitis B virus (HBV) infection is likely due to the interplay of the virus and host immune response. Given its critical role in antigen presentation, allelic differences in the HLA complex may affect HBV persistence. In a prospectively followed African American cohort, molecular class I and class II HLA typing was done on 31 subjects with persistent HBV infection and 60 controls who cleared the infection. HBV persistence was significantly associated with two class II alleles, DQA1 *0501 (odds ratio [OR], 2.6; P=.05) and DQB1 *0301 (OR, 3.9; P=.01), the two-locus haplotype consisting of these same two alleles (OR, 3; P=. 005) and the three-locus haplotype, DQA1 *0501, DQB1 *0301, and DRB1 *1102 (OR, 10.7; P=.01). In addition, HBV persistence was associated with class II allelic homozygosity. Several class I associations with persistence were also noted but were not statistically significant after correction for multiple comparisons. These results underscore the importance of the class II-mediated immune response in recovery from HBV infection. (+info)

MHC class II gene associations with autoantibodies to U1A and SmD1 proteins. (2/1046)

Autoantibodies against U small nuclear ribonucleoproteins (snRNP) are frequently present in the serum of patients with systemic rheumatic diseases, and have been reported to be associated with HLA-DR and -DQ genes. To better define the role of HLA genes in the production of such antibodies, we studied immunogenetic associations with autoantibodies reacting with U1 RNP, U1A and SmD1 proteins, and synthetic peptides containing immunodominant linear epitopes of these proteins. Only two out of the 15 overlapping peptides of U1A (i.e. peptides 35-58 and 257-282) and three of 11 peptides of SmD1 (i.e. peptides 1-20, 44-67 and 97-119) were significantly recognized by patients' sera selected on the basis of their antibody positivity with RNP in immunodiffusion. The distribution of DRB1, DQB1 and DPB1 alleles among the anti-RNP antibody-positive patients (n = 28) and healthy control subjects was similar. Antibodies against U1A (tested in Western immunoblotting with HeLa cell extracts) were positively associated to DRB1*06 allele; antibodies reacting with SmD1 peptide 44-67 were negatively associated to DRB1*02 and DQB1*0602 alleles. No association was found between DPB1 alleles and antibodies reacting with U1A and SmD1 antigens. This first study reporting an association between autoantibodies reacting with U1A and SmD1 proteins (and peptides of these proteins), and immunogenetic markers suggest that the production of antibody subsets directed against different components (or regions of these proteins) bound to the same snRNP particle is associated with distinct MHC class II alleles. (+info)

Immune responses against human papillomavirus (HPV) type 16 virus-like particles in a cohort study of women with cervical intraepithelial neoplasia. I. Differential T-helper and IgG responses in relation to HPV infection and disease outcome. (3/1046)

T-helper (Th) cell-dependent IL-2 production and plasma IgG responses to virus-like particles consisting of the human papillomavirus type 16 (HPV-16) major capsid protein L1 (L1-VLP) were determined in patients with cytological evidence of cervical intraepithelial neoplasia (CIN) participating in a non-intervention prospective cohort study. IgG responses were associated with HPV-16 persistence and high-grade CIN lesions, while high frequencies of Th responses were observed in patients with both virus clearance and virus persistence, irrespective of CIN grade. The IgG response was found in conjunction with an IL-2 response to L1-VLP in 87% of the patients. Recognition of the HPV-16 L1 Th epitope (amino acids 311-335) was found to be more closely associated than recognition of L1-VLP as a whole to HPV exposure and CIN development. Among the HPV-16+ patients included in this study, those showing a Th response to amino acids 311-335 were more likely to carry the HLA DRB1*11/DQB1*0301 haplotype, while those showing an IgG response to L1-VLP were more likely to carry DRB1*0101/DQB1*0501. However, neither cell-mediated nor humoral immune responses against HPV-16 L1 appear to be sufficient for the natural control of HPV infection and CIN development. (+info)

Major DQ8-restricted T-cell epitopes for human GAD65 mapped using human CD4, DQA10301, DQB10302 transgenic IA(null) NOD mice. (4/1046)

The 65KD isoform of GAD is considered to be a major target autoantigen in many humans with autoimmune prediabetes or diabetes. The major histocompatibility complex class II allele DQA1*0301, DQB1*0302, which encodes HLA-DQ8, confers susceptibility to type 1 diabetes and occurs in up to 80% of affected individuals. To map T-cell epitopes for GAD65 restricted to the diabetes-associated DQ8 heterodimer, we generated transgenic NOD mice expressing HLA-DQ8 and human CD4 while having the mouse class II gene (IA(beta)) deleted. These mice were immunized with full-length purified recombinant GAD65, and the fine specificity of T-cell responses was mapped by examining recall responses of bulk splenocytes to an overlapping set of 20-mer peptides encompassing the entire GAD65 protein. Four different peptides (P121-140, P201-220, P231-250, and P471-490) gave significant T-cell recall responses. P201-220 and P231-250 have been shown previously to bind DQ8, whereas the other two peptides had been classified as nonbinders. Interestingly, the peptide giving the greatest response (P201-220) encompasses residues 206-220 of GAD65, a region that has been shown to be a dominant T-cell epitope in wild-type IA(g7) NOD mice. Overlap in this T-cell epitope likely reflects structural similarities between DQ8 and IA(g7). The fine specificity of antibody responses in the GAD65-immunized mice was also examined by testing the antisera by enzyme-linked immunosorbent assay (ELISA) against the same overlapping set of peptides. The two dominant B-cell epitopes were P361-380 and P381-400; P121-140 and P471-490 appeared to correspond to both B- and T-cell epitopes. Although the NOD human CD4, DQ8, IA(null) transgenic mice generated in these studies do not develop autoimmune diabetes either spontaneously or after cyclophosphamide treatment, they can be used to map DQ8-restricted T-cell epitopes for a variety of human islet autoantigens. They can also be used to test T-cell-specific reagents, such as fluorescently labeled DQ8 tetramers containing GAD65 peptides or other beta-cell peptides, which we believe will be useful in analyzing human immune responses in diabetic and prediabetic patients. (+info)

Inhibition of allorecognition by a human class II MHC-derived peptide through the induction of apoptosis. (5/1046)

The interaction of the T-cell receptor with the major histocomatibility complex (MHC)-peptide complex is central to T-cell activation. Variation in the nature of the peptide bound within the groove of the MHC molecule may result in an altered T-cell response. Because some naturally processed peptides bound within the groove of the class II MHC molecule are derived from the MHC molecules themselves, we studied the inhibitory effects of synthetic class II MHC peptides on alloimmune responses in vitro. Three peptides derived from a highly conserved region of the class II MHC alpha chains inhibited the rat mixed lymphocyte response (MLR) in a dose-dependent manner, with the human HLA-DQA1 peptide also inhibiting the human and mouse MLR. No effect was seen on mitogen-induced T-cell proliferation. HLA-DQA1 inhibited cytolytic T lymphocyte (CTL) generation in a dose-response fashion, with no reduction in preformed CTL killing, suggesting that the inhibitory effect is targeted at CD4(+) T-cell function. Cell-cycle analysis by flow cytometry showed that restimulation of primed T cells in the presence of HLA-DQA1 resulted in increased apoptosis, whereas unstimulated cells were not affected. These data demonstrate that synthetic peptides derived from highly conserved regions of the class II MHC alpha chain can alter CD4(+) T-lymphocyte alloimmune responses in vitro, and this effect is mediated by the induction of apoptosis in activated T cells. (+info)

Influence of ethnic background on clinical and serologic features in patients with systemic sclerosis and anti-DNA topoisomerase I antibody. (6/1046)

OBJECTIVE: To investigate the effect of ethnicity on clinical and serologic expression in patients with systemic sclerosis (SSc) and anti-DNA topoisomerase I (anti-topo I) antibody. METHODS: Clinical and serologic features, as well as HLA class II allele frequencies, were compared among 47 North American white, 15 North American black, 43 Japanese, and 12 Choctaw Native American SSc patients with anti-topo I antibody. RESULTS: The frequency of progressive pulmonary interstitial fibrosis was lower, and cumulative survival rates were better in white compared with black and Japanese patients. Sera of white and black patients frequently recognized the portion adjacent to the carboxyl terminus of topo I, sera of Japanese patients preferentially recognized the portion adjacent to the amino terminus of topo I, and sera of Choctaw patients recognized both portions of topo I. Anti-RNA polymerase II and anti-SSA/Ro antibodies were present together with anti-topo I antibody more frequently in sera of Japanese patients than in sera of white patients. The HLA-DRB1 alleles associated with anti-topo I antibody differed; i.e., DRB1*1101-*1104 in whites and blacks, DRB1*1502 in Japanese, and DRB1*1602 in Choctaws. Multivariate analysis showed that ethnic background was an independent determinant affecting development of severe lung disease as well as survival. CONCLUSION: Clinical and serologic features in SSc patients were strongly influenced by ethnic background. The variability of disease expression in the 4 ethnic groups suggests that multiple factors linked to ethnicity, including genetic and environmental factors, modulate clinical manifestations, disease course, and autoantibody status in SSc. (+info)

Analysis of MHC class II DP, DQ and DR alleles in Crohn's disease. (7/1046)

BACKGROUND: Although inflammation in Crohn's disease is believed to be mediated by activated T cells, genotyping of all MHC class II alleles in white people with this disease has not been reported. AIMS: To perform a detailed molecular analysis of HLA DPB, DQB, and DRB genes in white patients with Crohn's disease and controls in order to determine if the inheritance of any class II genes confers susceptibility or resistance to this disease. METHODS: Complete molecular typing of HLA class II DPB, DQB, and DRB alleles was performed in 58 white patients with Crohn's disease and 93 healthy controls using a polymerase chain reaction-sequence specific oligonucleotide based approach. RESULTS: No significant association with any DPB or DQB alleles was noted in patients with Crohn's disease. Since our previous studies had shown a strong association of an HLA DRB3*0301/DRB1*1302 haplotype with Crohn's disease, we re-examined this association using more stringent genotyping criteria. This haplotype was present in 20.7% of patients and 5.4% of controls (p = 0.0066; relative risk = 4.59). CONCLUSIONS: The DRB3*0301/DRB1*1302 haplotype is the only significant MHC class II association noted in white people with Crohn's disease and represents the strongest association of any MHC or non-MHC locus with this disease. (+info)

Generation of humanized mice susceptible to peptide-induced inflammatory heart disease. (8/1046)

BACKGROUND: Dilated cardiomyopathy (DCM) is a major cause of sudden cardiac death. In certain mouse major histocompatibility complex (MHC) backgrounds, myocarditis and inflammatory cardiomyopathy can be triggered by immunization with heart muscle-specific proteins. Similarly, chronic heart disease in humans has been linked to certain HLA alleles, such as HLA-DQ6. However, there is no experimental evidence showing that human MHC class II molecules and peptides derived from human proteins are involved in the pathogenesis of myocarditis and DCM. METHODS AND RESULTS: We generated double CD4- and CD8-deficient mice transgenic for human CD4 (hCD4) and human HLA-DQ6 to specifically reconstitute the human CD4/DQ6 arm of the immune system in mice. Transgenic hCD4 and HLA-DQ6 expression rendered genetically resistant C57BL/6 mice susceptible to the induction of autoimmune myocarditis induced by immunization with cardiac myosin. Moreover, we identified heart-specific peptides derived from both mouse and human alpha-myosin heavy chains capable of inducing inflammatory heart disease in hCD4 and HLA-DQ6 double transgenic mice but not in hCD4 single transgenic littermates. The autoimmune inflammatory heart disease induced by the human heart muscle-specific peptide in hCD4 and HLA-DQ6 double transgenic mice shared functional and phenotypic features with the disease occurring in disease-susceptible nontransgenic mice. CONCLUSIONS: Our data provide the first genetic and functional evidence that human MHC class II molecules and a human alpha-myosin heavy chain-derived peptide can cause inflammatory heart disease and suggest that human inflammatory cardiomyopathy can be caused by organ-specific autoimmunity. The humanized mice generated in this study will be an ideal animal model to further elucidate the pathogenesis of inflammatory heart disease and facilitate the development of rational treatment strategies. (+info)

The primary symptoms of celiac disease include diarrhea, abdominal pain, fatigue, weight loss, and bloating. However, some people may not experience any symptoms at all, but can still develop complications if the disease is left untreated. These complications can include malnutrition, anemia, osteoporosis, and increased risk of other autoimmune disorders.

The exact cause of celiac disease is unknown, but it is believed to be triggered by a combination of genetic and environmental factors. The disease is more common in people with a family history of celiac disease or other autoimmune disorders. Diagnosis is typically made through a combination of blood tests and intestinal biopsy, and treatment involves a strict gluten-free diet.

Dietary management of celiac disease involves avoiding all sources of gluten, including wheat, barley, rye, and some processed foods that may contain hidden sources of these grains. In some cases, nutritional supplements may be necessary to ensure adequate intake of certain vitamins and minerals.

While there is no known cure for celiac disease, adherence to a strict gluten-free diet can effectively manage the condition and prevent long-term complications. With proper management, people with celiac disease can lead normal, healthy lives.

... and less closely linked to HLA-DP, HLA-A, HLA-B and HLA-C. Different isoforms of DQ can bind to and present different antigens ... HLA-DQ (DQ) is encoded on the HLA region of chromosome 6p21.3, in what was classically known as the "D" antigen region. This ... HLA-DQ (DQ) is a cell surface receptor protein found on antigen-presenting cells. It is an αβ heterodimer of type MHC class II ... HLA DQ functions as a cell surface receptor for foreign or self antigens. The immune system surveys antigens for foreign ...

https://en.wikipedia.org/wiki/HLA-DQ

Tissue Antigens. 40 (1): 31-37. doi:10.1111/j.1399-0039.1992.tb01954.x. PMID 1440559. (HLA-DQ haplotypes, MHC class II). ... HLA-DQ4 (DQ4) is a serotype subgroup within HLA-DQ(DQ) serotypes. The serotype is determined by the antibody recognition of β4 ... subset of DQ β-chains. The β-chain of DQ is encoded by HLA-DQB1 locus and DQ4 are encoded by the HLA-DQB1*04 allele group. This ... Tanaka T, Ohmori M, Yasunaga S, Ohshima K, Kikuchi M, Sasazuki T (1999). "DNA typing of HLA class II genes (HLA-DR, -DQ and -DP ...

https://en.wikipedia.org/wiki/HLA-DQ4

HLA-DQ2, a human leukocyte antigen of the HLA DQ type. This disambiguation page lists articles associated with the same title ...

https://en.wikipedia.org/wiki/DQ2

DQ beta 2". Piatier-Tonneau D, Gastinel LN, Amblard F, et al. (1991). "Interaction of CD4 with HLA class II antigens and HIV ... HLA class II histocompatibility antigen, DX beta chain is a protein that in humans is encoded by the HLA-DQB2 gene. ... 1994). "HLA class II antigens and the HIV envelope glycoprotein gp120 bind to the same face of CD4". J. Immunol. 152 (9): 4475- ... Comparisons of the DQ and DX alpha and beta genes". J. Biol. Chem. 262 (18): 8767-77. doi:10.1016/S0021-9258(18)47482-0. PMID ...

https://en.wikipedia.org/wiki/HLA-DQB2

... (DQ6) is a human leukocyte antigen serotype within HLA-DQ (DQ) serotype group. The serotype is determined by the ... Achord AP, Lewis RE, Brackin MN, Henderson H, Cruse JM (1996). "HIV-1 disease association with HLA-DQ antigens in African ... The β-chain of DQ isoforms are encoded by HLA-DQB1 locus and DQ6 are encoded by the HLA-DQB1*06 allele group. This group ... 2000). "HLA-DR and -DQ associations with insulin-dependent diabetes mellitus in a population of Turkey". Hum. Immunol. 61 (3): ...

https://en.wikipedia.org/wiki/HLA-DQ6

... (DQ5) is a human leukocyte antigen serotype subgroup within HLA-DQ(DQ) serotypes. The serotype is determined by the ... Wang JF, Zhang D, Zhao JZ, Jia BX, Bi RM (2006). "A study on the relationship between HLA-DR, DQ antigen, and intracranial ... The β-chain of DQ is encoded by HLA-DQB1 locus and DQ5 are encoded by the HLA-DQB1*05 allele group. This group currently ... HLA-DQ5 and HLA-DQB1*05 are almost synonymous in meaning. DQ5 β-chains combine with α-chains, encoded by genetically linked HLA ...

https://en.wikipedia.org/wiki/HLA-DQ5

DR16 is part of the older HLA-DR2 serotype group which also contains the similar HLA-DR15 antigens. DR16 is associated with ... Park M, Park Y, Song E, Park H, Kim T, Park D, Park K, Cho B (2005). "Association of HLA-DR and -DQ genes with Graves disease ... systemic sclerosis HLA-DR16 is genetically linked to HLA-DR51 and HLA-DQ5 serotypes. derived from IMGT/HLA Cruz-Robles D, Reyes ... Dharakul T, Vejbaesya S, Chaowagul W, Luangtrakool P, Stephens H, Songsivilai S (1998). "HLA-DR and -DQ associations with ...

https://en.wikipedia.org/wiki/HLA-DR16

... (DQ9) is a human leukocyte antigen serotype within the HLA-DQ (DQ) serotype group. DQ9 is a split antigen of the DQ3 ... derived from IMGT/HLA Zhai L, Sun Y, Tang L, Liu H (2007). "Polymorphism between loci for human leukocyte antigens DR and DQ in ... Törn C, Gupta M, Sanjeevi CB, Aberg A, Frid A, Landin-Olsson M (2004). "Different HLA-DR-DQ and MHC class I chain-related gene ... 1994). "Analysis of MHC class II antigens in Japanese IDDM by a novel HLA-typing method, hybridization protection assay". ...

https://en.wikipedia.org/wiki/HLA-DQ9

... of the HLA-DQ protein. HLA-DQ is part of the MHC class II antigen-presenting receptor (also called the human leukocyte antigen ... The two subunits of the HLA-DQ protein are encoded by the HLA-DQA1 and HLA-DQB1 genes, located on the short arm of chromosome 6 ... but as a negative HLA-DQ type excludes the diagnosis of coeliac disease, testing also for HLA-DQ2 or DQ8 maximises sensitivity ... Only the HLA-DQ loci show a consistent involvement over the global population. Many of the loci detected have been found in ...

https://en.wikipedia.org/wiki/Coeliac_disease

... is a serotype that covers a broad range of HLA-DQ haplotypes. Historically it was identified as a DR-like alpha chain ... 1992). "Association of HLA-B51 and lack of association of class II alleles with Behçet's disease". Tissue Antigens. 40 (1): 22- ... Olerup O, Olsson R, Hultcrantz R, Broome U (1995). "HLA-DR and HLA-DQ are not markers for rapid disease progression in primary ... 1994). "HLA-DQA1, -DQB1 and -DRB1 genotyping in Japanese pemphigus vulgaris patients by the PCR-RFLP method". Tissue Antigens. ...

https://en.wikipedia.org/wiki/HLA-DQ1

... (DQ8) is a human leukocyte antigen serotype within the HLA-DQ (DQ) serotype group. DQ8 is a split antigen of the DQ3 ... "Frequencies of HLA-A, HLA-B, HLA-DR, and HLA-DQ phenotypes in the United Arab Emirates population". Tissue Antigens. 66 (2): ... Pimtanothai N, Hurley C, Leke R, Klitz W, Johnson A (2001). "HLA-DR and -DQ polymorphism in Cameroon". Tissue Antigens. 58 (1 ... October 2003). "New HLA haplotype frequency reference standards: high-resolution and large sample typing of HLA DR-DQ ...

https://en.wikipedia.org/wiki/HLA-DQ8

"HLA DR and DQ polymorphism in Ashkenazi and non-Ashkenazi Jews: comparison with other Mediterraneans". Tissue Antigens. 47 (1 ... HLA DR3-DQ2 encodes DQ2.5cis isoform of HLA-DQ, this isoform is described frequently as 'the DQ2 isoform', but in actuality ... HLA DR3-DQ2 is double serotype that specifically recognizes cells from individuals who carry a multigene HLA DR, DQ haplotype. ... Jönsen A, Bengtsson A, Sturfelt G, Truedsson L (2004). "Analysis of HLA DR, HLA DQ, C4A, FcgammaRIIa, FcgammaRIIIa, MBL, and IL ...

https://en.wikipedia.org/wiki/HLA_DR3-DQ2

Prior to refined typing for HLA-DQ and DR, the association with HLA-A1 and B8 was identified for coeliac disease in 1973 and ... "Correlation between acetylcholine receptor antibody titer and HLA-B8 and HLA-DRw3 antigens in myasthenia gravis". Trans Am ... In one study 65% of patients with end stage autoimmune hepatitis had coeliac associated HLA-DQ (DQ2, DQ8), of these half had ... Hammarström L, Smith E, Möller E, Franksson C, Matell G, Von Reis G (August 1975). "Myasthenia gravis: studies on HL-A antigens ...

https://en.wikipedia.org/wiki/HLA_A1-B8-DR3-DQ2

"HLA-DR antigens in pemphigus among Japanese". Tissue Antigens. 17 (2): 238-9. doi:10.1111/j.1399-0039.1981.tb00689.x. PMID ... Hermann R, Turpeinen H, Laine A, Veijola R, Knip M, Simell O, Sipilä I, Akerblom H, Ilonen J (2003). "HLA DR-DQ-encoded genetic ... HLA-DR4 (DR4) is an HLA-DR serotype that recognizes the DRB1*04 gene products. The DR4 serogroup is large and has a number of ... derived from IMGT/HLA Roudier J (2006). "HLA-DRB1 genes and extraarticular rheumatoid arthritis". Arthritis Research & Therapy ...

https://en.wikipedia.org/wiki/HLA-DR4

... amplification and human leukocyte antigen (HLA)-DQ alpha oligonucleotide typing on biological evidence samples: casework ... The DQ alpha 1 locus (or location) was also polymorphic and had multiple different alleles that could be used to limit the pool ... The DQ alpha locus was combined with other loci in a commercially available kit called Polymarker in 1993. Polymarker was a ... Developed in 1991, DQ alpha testing was the first forensic DNA technique that utilized the polymerase chain reaction. This ...

https://en.wikipedia.org/wiki/Forensic_DNA_analysis

HLA-DR, -DQ and -DP) in Japanese patients with histiocytic necrotizing lymphadentis (Kikuchi's disease) 8". Tissue Antigens. 54 ... Certain Human leukocyte antigen class II genes appear more frequently in patients with Kikuchi disease, suggesting that there ... Tanaka, T.; Ohmori, M.; Yasunaga, S.; Ohshima, K.; Kikuchi, M.; Sasazuki, T. (1999). "DNA typing of HLA class II genes ( ...

https://en.wikipedia.org/wiki/Kikuchi_disease

... high-resolution and large sample typing of HLA DR-DQ haplotypes in a sample of European Americans". Tissue Antigens. 62 (4): ... Antigens most responsible for graft loss are HLA-DR (first six months), HLA-B (first two years), and HLA-A (long-term survival ... The HLA-DRB4 locus encodes the HLA-DR53 specificity, has some variation, and is associated with certain HLA-DRB1 types. The HLA ... and at the HLA-DRB1 locus to a greater degree relative to HLA-DQB1 and HLA-DPB1. Most of the HLA alleles currently present in ...

https://en.wikipedia.org/wiki/HLA-DR

"Redundancy in antigen-presenting function of the HLA-DR and -DQ molecules in the multiple sclerosis-associated HLA-DR2 ... leprosy HLA-DRB5 (DR51)is linked to the following HLA-DR serotypes and DRB1 allele groups. HLA-DR2 HLA-DR15 - DRB1*15 HLA-DR16 ... HLA-DR51 is a HLA-DR serotype that recognizes the antigens encoded by the minor DR locus HLA-DRB5. DRB3, DRB4, and DRB5 are ... Gongora R, Figueroa F, Klein J (1996). "The HLA-DRB9 gene and the origin of HLA-DR haplotypes". Hum. Immunol. 51 (1): 23-31. ...

https://en.wikipedia.org/wiki/HLA-DR51

Major histocompatibility complex Human leukocyte antigen HLA-DQ "Entrez Gene: HLA-DQB1 major histocompatibility complex, class ... Major histocompatibility complex, class II, DQ beta 3, also known as HLA-DQB3, is a human gene and also denotes the genetic ... II, DQ beta 1". Ando A, Kawai J, Maeda M, Tsuji K, Trowsdale J, Inoko H (1989). "Mapping and nucleotide sequence of a new HLA ... While the overall sequence of the protein encoded by this gene is similar to other HLA class II beta chains, the translated ...

https://en.wikipedia.org/wiki/HLA-DQB3

... high-resolution and large sample typing of HLA DR-DQ haplotypes in a sample of European Americans". Tissue Antigens. 62 (4): ... HLA-DQ7 (DQ7) is an HLA-DQ serotype that recognizes the common HLA DQB1*0301 and the less common HLA DQB1*0304 gene products. ... a large number of DQ αβ isoforms. These DQ alpha chains are also known to form transhaplotype isomers with other HLA-DQ. DQ7 is ... Guo X, Ni P, Li L (2001). "[Association between asthma and the polymorphism of HLA-DQ genes]". Zhonghua Jie He He Hu Xi Za Zhi ...

https://en.wikipedia.org/wiki/HLA-DQ7

... high-resolution and large sample typing of HLA DR-DQ haplotypes in a sample of European Americans". Tissue Antigens. 62 (4): ... HLA-DR7 may also be associated with these antibodies and the common haplotype association is the HLA-DR53 serotype.[citation ... The haplotype HLA-DR4-DQ3 appears to play a role in the pathogenic AAHA production. The alleles primarily recognized are HLA- ... 2000). "HLA class II alleles associations of anticardiolipin and anti-beta2GPI antibodies in a large series of European ...

https://en.wikipedia.org/wiki/Anti-apolipoprotein_antibodies

HLA class II histocompatibility antigen, DQ(6) alpha chain is a protein that in humans is encoded by the HLA-DQA2 gene. Also ... 1987). "Structure and expression of HLA-DQ alpha and -DX alpha genes: interallelic alternate splicing of the HLA-DQ alpha gene ... 1994). "HLA class II antigens and the HIV envelope glycoprotein gp120 bind to the same face of CD4". J. Immunol. 152 (9): 4475- ... "Entrez Gene: HLA-DQA2 major histocompatibility complex, class II, DQ alpha 2". Rudy GB, Lew AM (March 1997). "The ...

https://en.wikipedia.org/wiki/HLA-DQA2

HLA class II histocompatibility antigen, DP(W2) beta chain is a protein that in humans is encoded by the HLA-DPB1 gene. HLA-DPB ... 1992). "Family study on HLA-DPB1 polymorphism: linkage analysis with HLA-DR/DQ and two "new" alleles". Hum. Immunol. 34 (3): ... 1991). "Modulation of the HLA class II antigen at a molecular level by maternal serum among cord blood cells and unrelated ... Eiermann TH, Uhl S, Fakler J, Goldmann SF (1992). "A novel HLA-DPB1 sequence, DPB1*2301". Tissue Antigens. 40 (2): 108-10. doi: ...

https://en.wikipedia.org/wiki/HLA-DPB1

HLA-DQ2 primarily presents gliadins with the HLA-DQ isoform DQ2.5 (DQ α5-β2) isoform. DQA1*0202:DQB1*0201 homozygotes (DQ α2-β2 ... The HLA-A antigens can mediate apoptosis in autoimmune disease and HLA A*0201 in with the HLA-DQ8 haplotypes has been ... and therefore HLA-DQ can recognize many motifs on each gliadin (see Understanding DQ haplotypes and DQ isoforms on the right) ... Understanding DQ haplotypes and DQ isoforms). HLA-DQ8 is generally not as involved in the most severe complications, and it ...

https://en.wikipedia.org/wiki/Gluten_immunochemistry

DQw3 was one of three early determined antigens recognized as HLA-DQ along with HLA-DQ1 and HLA-DQ2. While the DQ3 molecules ... Within molecular and cell biology, HLA-DQ3 (DQ3) is a broad serotype category with split antigens HLA-DQ7, DQ8, and DQ9. ... DQB1*0301 the DQ7 gene, is detailed on HLA-DQ7 DQB1*0302 the DQ8 gene, is detailed on HLA-DQ8 DQB1*0303 the DQ9 gene, is ... derived from IMGT/HLA (All articles with dead external links, Articles with dead external links from January 2020, Articles ...

https://en.wikipedia.org/wiki/HLA-DQ3

The HLA-DQ proteins that predispose individuals to coeliac disease bind and respond specifically to gluten-related antigens ... HLA-DQ proteins are composed of α and β polypeptide chains encoded by the HLA-DQA1 and HLA-DQB1 genes, respectively. Since ... Ninety to one hundred percent of patients with coeliac disease have inherited genes at the HLA-DQ locus that encode HLA-DQ2 and ... HLA-DQ proteins are on the surface of APC and function to present foreign or self antigens to the T cell receptors (TCR) ...

https://en.wikipedia.org/wiki/Enteropathy-associated_T-cell_lymphoma

"Strong associations between specific HLA-DQ and HLA-DR alleles and the tubulointerstitial nephritis and uveitis syndrome". ... "HLA-DR antigens in rheumatoid arthritis. A Swiss collaborative study; final report. Swiss Federal Commission for the Rheumatic ... HLA-DR1 is not genetically linked to DR51, DR52 or DR53, but is linked to HLA-DQ1 and DQ5 serotypes. Fernández MM, Guan R, ... HLA-DR1 (DR1) is a HLA-DR serotype that recognizes the DRB1*01 gene products. It has been observed to be common among ...

https://en.wikipedia.org/wiki/HLA-DR1

... a human leukocyte antigen of the HLA-DQ type. This disambiguation page lists articles associated with the same title formed as ... DQ3 may be: Deltora Quest 3, a children's book Dragon Quest III, a console role-playing game (RPG) HLA-DQ3, ...

https://en.wikipedia.org/wiki/DQ3

Major histocompatibility complex Human leukocyte antigen HLA-DQ ENSG00000206237, ENSG00000231286, ENSG00000206302, ... HLA class II histocompatibility antigen, DQ beta 1 chain) at the PDBe-KB. v t e (Genes on human chromosome 6, MHC class II, All ... "Entrez Gene: HLA-DQB1 major histocompatibility complex, class II, DQ beta 1". Lau M, Terasaki PI, Park MS (1994). " ... Major histocompatibility complex, class II, DQ beta 1, also known as HLA-DQB1, is a human gene and also denotes the genetic ...

https://en.wikipedia.org/wiki/HLA-DQB1

... a Human leukocyte antigen HLA-DQ serotype that recognizes the DQB1*04 gene products This disambiguation page lists articles ... DQ4 could refer to: Dragon Quest IV: Chapters of the Chosen, a video game published by Enix (now Square Enix) HLA-DQ4, ...

https://en.wikipedia.org/wiki/DQ4

6p21.3) HLA-DQA1 and HLA-DQB1 form HLA-DQ heterodimer MHC class II, DQ: Celiac1, IDDM (6p21.3) HLA-DRA, HLA-DRB1, HLA-DRB3, HLA ... The human leukocyte antigen lies on chromosome 6, with the exception of the gene for β2-microglobulin (which is located on ... HLA-DRB5 forms HLA-DR, heterodimer MHC class II, DR (6p21.3) Mold / Biotoxin Susceptibility HLA-DPA1 and HLA-DPB1 forms HLA-DP ... HLA-DR CIRS (Chronic Inflammatory Response Syndrome ), Sick Building Syndrome, Mold Toxin Susceptibility / Poisoning, HLA-DR/DQ ...

https://en.wikipedia.org/wiki/Chromosome_6

SAgs show preference for the HLA-DQ form of the molecule. Binding to the α-chain puts the SAg in the appropriate position to ... SAg stimulation of antigen presenting cells and T-cells elicits a response that is mainly inflammatory, focused on the action ... Compared to a normal antigen-induced T-cell response where 0.0001-0.001% of the body's T-cells are activated, these SAgs are ... This occurs because a cognate antigen activates a T cell not because of its structure per se, but because its affinity allows ...

https://en.wikipedia.org/wiki/Superantigen

Major histocompatibility complex Human leukocyte antigen HLA-DQ ENSG00000206305, ENSG00000225890, ENSG00000232062, ... 1987). "Complete sequence of the HLA DQ alpha and DQ beta cDNA from a DR5/DQw3 cell line". J. Immunol. 139 (1): 228-33. PMID ... rare among serotypes for human class II antigens, in that the antibodies to DQ1 react to the alpha chain of HLA DQ, these DQA1 ... "Entrez Gene: HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1". Lau M, Terasaki PI, Park MS (1994). " ...

https://en.wikipedia.org/wiki/Major_histocompatibility_complex,_class_II,_DQ_alpha_1

June 2007). "HLA alleles as predisposal factors for postmenopausal osteoporosis in a Greek population". Tissue Antigens. 69 (6 ... August 2002). "Risk of invasive cervical cancer associated with polymorphic HLA DR/DQ haplotypes". Int. J. Cancer. 100 (6): 698 ... Müller C, Ehninger G, Goldmann S (2003). "Gene and haplotype frequencies for the loci hLA-A, hLA-B, and hLA-DR based on over ... HLA B7-DR15-DQ6 is a representation(by serotype) of a common HLA haplotype found in Western Eurasia. The haplotype can be ...

https://en.wikipedia.org/wiki/HLA_B7-DR15-DQ6

Those peptides expressing a drug-related, non-self epitope on their HLA-A, HLA-B, HLA-C, HLA-DM, HLA-DO, HLA-DP, HLA-DQ, or HLA ... places the peptides in a groove on the human leukocyte antigen (i.e. HLA) component of their major histocompatibility complex ( ... Phenytoin: Han Chinese individuals expressing HLA-B13:01, HLA-B51:01, HLA-B15:02, HLA-Cw*08:01, or HLA-DRB1*16:02 serotypes ... Nevirapine: Africans, Asians, and Europeans expressing HLA-DRB1:01:01 or HLA-DRB1:01:02, or HLA-Cw4 serotypes, Asians ...

https://en.wikipedia.org/wiki/Drug_reaction_with_eosinophilia_and_systemic_symptoms

"An extensive screen of the HLA region reveals an independent association of HLA class I and class II with susceptibility for ... Pan HF, Wu GC, Li WP, Li XP, Ye DQ (March 2010). "High Mobility Group Box 1: a potential therapeutic target for systemic lupus ... That leads to the maturation of DCs and also to the presentation of intracellular antigens of late apoptotic or secondary ... HLA class I, class II, and class III genes are associated with SLE, but only classes I and II contribute independently to ...

https://en.wikipedia.org/wiki/Lupus

HLA-DRB1*04:05, HLA-B*39:01, and HLA-B*15:01 are associated with independent MS susceptibility and HLA-DQβ1 position 9 with ... August 2019). "Molecular mimicry between Anoctamin 2 and Epstein-Barr virus nuclear antigen 1 associates with multiple ... Different behaviour has been reported according to the presence of different HLA genes. In HLA DRB3 cases, autoimmune reactions ... In HLA-DRB3*02:02 patients, autoimmune reactions against the enzyme GDP-L-fucose synthase has been reported The same report ...

https://en.wikipedia.org/wiki/Inflammatory_demyelinating_diseases_of_the_central_nervous_system

HLA-A, HLA-B, HLA-C, HLA-DM, HLA-DO, HLA-DP, HLA-DQ, or HLA-DR) can bind to a T-cell receptor and thereby stimulate the ... Individuals expressing certain human leukocyte antigen (i.e. HLA) serotypes (i.e. genetic alleles), genetical-based T cell ... and phenytoin-induced SJS is strongly associated with HLA-B*1502 (HLA-B75), an HLA-B serotype of the broader serotype HLA-B15. ... In addition to acting through HLA proteins to bind with a T-cell receptor, a drug or its metabolite may bypass HLA proteins to ...

https://en.wikipedia.org/wiki/Stevens–Johnson_syndrome

Mehra sits on the editorial board of HLA (journal) (formerly known as Tissue Antigens) and is a member of the International ... mellitus patients from the Western Caucasian patients by demonstrating that the former showed a pattern of HLA-DR and HLA-DQ ... Later, in India, he studied HLA-linked genes and identified that a subtype of HLA-DR2 carried a unique class II haplotype which ... Besides, he has published a book, The HLA Complex in Biology and Medicine: A Resource Book, and has contributed chapters to ...

https://en.wikipedia.org/wiki/Narinder_Kumar_Mehra

"Nomenclature for factors of the HLA system, 2010". Tissue Antigens. 75 (4): 291-455. doi:10.1111/j.1399-0039.2010.01466.x. PMC ... This haplotype can generally be extended from A- to -DQ as A29-Cw16-B44-DR7-DQ2.2: A*2901 : Cw*1601 : B*4403 : DRB1*0701 : DQA1 ... HLA-Cw*16 (Cw*16) is an HLA-C allele-group. The serotype identifies the more common HLA-Cw*16 gene products. This allele group ... 1989). "Three new class I HLA alleles: structure of mRNAs and alternative mechanisms of processing". Immunogenetics. 29 (2): 80 ...

https://en.wikipedia.org/wiki/HLA-Cw*16

and by most (95%) individuals with EATL being of either the HLA-DQ2 or HLA-DQ8 rather than other HLA-DQ haplotypes. Extranodal ... and T-cell intracellular antigen-1) but no genetic abnormalities. Indolent T cell lymphoproliferative disorder of the ...

https://en.wikipedia.org/wiki/Monomorphic_epitheliotropic_intestinal_T_cell_lymphoma

DR15 is part of the older HLA-DR2 serotype group which also contains the similar HLA-DR16 antigens. Serotypes are unknown for ... Apple R, Erlich H, Klitz W, Manos M, Becker T, Wheeler C (1994). "HLA DR-DQ associations with cervical carcinoma show ... DQB1*0501 haplotype is associated with systemic lupus erythematosus HLA-DR15 is genetically linked to HLA-DR51 and HLA-DQ6 (HLA ... 2007). "Analysis of HLA antigens in Turkish sarcoidosis patients". South. Med. J. 100 (4): 356-9. doi:10.1097/SMJ. ...

https://en.wikipedia.org/wiki/HLA-DR15

... or the HLA-DQ (alpha 1*03, beta 1*0302) heterodimers". Tissue Antigens. 49 (1): 29-34. doi:10.1111/j.1399-0039.1997.tb02706.x. ... and is associated with the human leukocyte antigen (HLA) haplotype HLA-DQ2 or HLA-DQ8 along with coeliac disease and gluten ... tTG is treated as an autoantigen, especially in people with certain HLA-DQ2 and HLA-DQ8 alleles and other gene variants that ... "Dermatitis herpetiformis and celiac disease are both primarily associated with the HLA-DQ (alpha 1*0501, beta 1*02) ...

https://en.wikipedia.org/wiki/Dermatitis_herpetiformis

The NKR implemented a standardized HLA coding scheme and forced the identification of more antigen and antibody data such as DP ... Bw, Cw, DQ and DQA. This refinement and expansion of HLA data increased the virtual cross match accuracy from less than 50% to ... Baxter-Lowe; Cecka; Kamoun; Sinacore; Melcher (February 26, 2016). "Center-Defined Unacceptable HLA Antigens Facilitate ... HLA coding standardization - In the startup period, the NKR experienced virtual cross match failure rates in excess of 50% ...

https://en.wikipedia.org/wiki/National_Kidney_Registry

A panel of DNA samples from old cases was collected and coded, and was analyzed blind by Saiki using the HLA DQα assay. When ... Primers and probes were designed for a variable segment of the Human leukocyte antigen DQα gene. This reaction was much more ... "Analysis of enzymatically amplified β-globin and HLA DQα DNA with allele-specific oligonucleotide probes." Nature vol. 324 ( ... This DQα test is developed by Cetus as one of their "Ampli-Type" kits, and became part of early protocols for the testing of ...

https://en.wikipedia.org/wiki/History_of_polymerase_chain_reaction

They load processed peptides onto MHC class II (i.e. HLA-DM, HLA-DO, HLA-DP, HLA-DQ, or HLA-DR) proteins and thereon present ... antigens) on foreign proteins. These proteins are taken up by antigen-presenting cells (APC) and degraded into small peptides. ... Non-professional APC include all nucleated cells; these cells load the processed peptides onto MHC class I (i.e. HLA-A, HLA-B, ... Humans, it is estimated, express more than 10,000 different HLA class I proteins, 3,000 different HLA class II proteins, and ...

https://en.wikipedia.org/wiki/Severe_cutaneous_adverse_reactions

... high-resolution and large sample typing of HLA DR-DQ haplotypes in a sample of European Americans". Tissue Antigens. 62 (4): ... HLA-DQ3 (DQ3) is a serotype group within HLA-DQ (DQ) serotyping system. The serotype is determined by the antibody recognition ... The β-chain of DQ is encoded by HLA-DQB1 locus and DQ2 are encoded by the HLA-DQB1*02 allele group. This group currently ... HLA-DQ2 and HLA-DQB1*02 are almost synonymous in meaning. DQ2 β-chains combine with α-chains, encoded by genetically linked HLA ...

https://en.wikipedia.org/wiki/HLA-DQ2

IL-28B and HLA class II are independently associated with spontaneous resolution of HCV infection, and SNPs marking IL-28B and ... HLA-DQ beta-Chains * HLA-DQB1 antigen * Hepatitis C Antibodies * IFNL3 protein, human ... Conclusion: IL-28B and HLA class II are independently associated with spontaneous resolution of HCV infection, and SNPs marking ... On chromosome 6, allele frequency differences localized near genes for HLA class II and included rs4273729 (overall per-allele ...

https://pubmed.ncbi.nlm.nih.gov/23420232/

The HLA-DQB1 gene provides instructions for making a protein that plays a critical role in the immune system. Learn about this ... HLA-DQ locus of the human leukocyte antigen complex and type 1 diabetes mellitus: a HuGE review. Epidemiol Rev. 2000;22(2):218- ... The HLA-DQB1 gene is part of a family of genes called the human leukocyte antigen (HLA) complex. The HLA complex helps the ... 01 or HLA-DQB1*02:02 bound to the protein produced from HLA-DQA1 gene variants known as HLA-DQA1*05:01 or HLA-DQA1*05:05. The ...

https://medlineplus.gov/genetics/gene/hla-dqb1/

The HLA-DQA1 gene provides instructions for making a protein that plays a critical role in the immune system. Learn about this ... HLA class II histocompatibility antigen, DQ alpha 1 chain. *HLA class II histocompatibility antigen, DQ alpha 1 chain precursor ... The HLA-DQA1 gene is part of a family of genes called the human leukocyte antigen (HLA) complex. The HLA complex helps the ... 01 or HLA-DQA1*05:05 bound to the protein produced from HLA-DQB1 gene variants known as HLA-DQB1*02:01 or HLA-DQB1*02:02. The ...

http://ghr.nlm.nih.gov/gene/HLA-DQA1

The relationship between HLA-A, B, DQ, and DR antigens and asbestos-induced lung disease. ...

http://www2.cdc.gov/nioshtic-2/BuildQyr.asp?s1=asbestos%2A&f1=TI&Startyear=&t1=1&s2=asbestos%2A&B1=Search&terms=3&Adv=1&f2=KW&Limit=500&Sort=DP%2BDESC&D1=75&EndYear=&PageNo=425&RecNo=425&View=b&

In conjunction with the CD3/TCR complex and CD4 molecules, HLA ... HLA-DR is a heterodimeric cell surface glycoprotein comprised ... It does not cross react with HLA-DP and HLA-DQ. Clone L243 binds a conformational epitope on HLA-DRa which depends on the ... MHC Antigens Antigen References 1. Levacher M, et al. 1990. Clin. Exp. Immunol. 81:177.. 2. Terstappen L, et al. 1990. J. ... The L243 monoclonal antibody reacts with the HLA-DR antigen, a member of MHC class II molecules. ...

https://www.biolegend.com/ja-jp/products/spark-violet-500-anti-human-hla-dr-antibody-22648

Of these three serotyping specificities only DQw1 recognized DQ alpha chain. The serotype is positive in individuals who bear ... In the illustration on the right, DQ1 serotyping antibodies recognizes the DQ alpha (magenta), where antibodies to DQA1* gene ... HLA-DQ1 is a serotype that covers a broad range of HLA-DQ haplotypes. Historically it was identified as a DR-like alpha chain ... DQ beta 1; MHC class II antigen DQB1; MHC class II antigen HLA DQ beta 1; MHC class II DQ beta chain; MHC class II HLA DQ beta ...

https://www.creativebiomart.net/symbolsearch_hla-dqb1.htm

... who carry specific human leukocyte antigen (HLA)-DQ genotypes conferring increased susceptibility to type 1 diabetes, were ... selective genotyping of markers in the HLA-DQB1, HLA-DQA1 and HLA-DRB1 loci. Diabet Med. 1999;16:985-92. DOIPubMedGoogle ... By the end of 2002, a total of 68,953 newborn children (27,030 in Turku) had been tested for their HLA-conferred risk for type ... The 109 DIPP children in this study were randomly chosen (computer algorithm that gives equal relative amounts of all HLA types ...

https://wwwnc.cdc.gov/eid/article/18/2/11-1293

While this mechanism might seemingly imply that host protein incorporation is a passive uptake of all cellular antigens ... Early reports indicated that certain isotypes of human lymphocyte antigen (HLA) class II, such as HLA-DP and HLA-DQ, were ... A study that aimed to test the functionality of HLA-DR in antigen presentation showed that virions with incorporated HLA-DR, ... Subsequent work demonstrated that HLA-DP and HLA-DQ were indeed present on some virions, but that incorporation was dependent ...

https://www.mdpi.com/1999-4915/11/1/85/htm

HLA DQ Antigens HLA DS Antigens HLA LB Antigens HLA MB Antigens HLA-DC HLA-DC Antigens HLA-DQ HLA-DS HLA-DS Antigens HLA-LB HLA ... HLA DC Antigens. HLA DQ Antigens. HLA DS Antigens. HLA LB Antigens. HLA MB Antigens. HLA-DC. HLA-DC Antigens. HLA-DQ. HLA-DS. ... HLA-DQ Antigens Entry term(s). Antigens, HLA-DC Antigens, HLA-DQ Antigens, HLA-DS Antigens, HLA-LB Antigens, HLA-MB HLA DC ... Antigènes HLA-DQ Entry term(s):. Antigens, HLA-DC. Antigens, HLA-DQ. Antigens, HLA-DS. Antigens, HLA-LB. Antigens, HLA-MB. ...

https://decs.bvsalud.org/en/ths/resource/?id=24252

Human leucocyte antigens (HLA) are linked with immune response capability and might indicate a possible genetic susceptibility ... They were interviewed for symptoms and occupational history and gave a blood specimen for HLA-A, -B, -DR, and -DQ typing and ... This study is the first to find significant HLA antigen excesses among a series of silicotic cases and extends earlier reported ... No perturbations in D-region antigen frequencies were detected. B44-positive subjects were older at diagnosis and had less ...

http://www2a.cdc.gov/nioshtic-2/BuildQyr.asp?s1=silica&t3=2&f1=TI&Startyear=&t1=1&s2=silicosis&terms=4&Adv=1&ct=&B1=Search&f2=TI&t2=2&Limit=500&Sort=DP+DESC&s3=animals&f3=TI&s4=rats&EndYear=&f4=TI&whichdate=DP&D1=10&PageNo=80&RecNo=794&View=f&

HLA alleles A, B, C, DR, and DQ). --9/10 donors where all the HLA sequences have the same antigen/peptide binding domains in ... Availability of HLA identical or single HLA locus mismatched family donor or 10/10 matched unrelated donor at the allelic level ...

https://clinicalstudies.info.nih.gov/protocoldetails.aspx?id=10-H-0154&query=

HLA-E, HLA-F, and HLA-G). Class II is made up of HLA-DR, HLA-DP, and HLA-DQ, as well as variations on these genes. ... A match of 3-4 of the 6 HLA-A, HLA-B and HLA-DRB1 antigens is sufficient for transplantation. For the same reason, the degree ... Traditionally, the loci critical for matching are HLA-A, HLA-B, and HLA-DR.HLA-C and HLA-DQ are also now considered when ... the investigators found a link between patient mortality and HLA-A, HLA-B, HLA-C, and HLA-DRB1, but not HLA-DQB1 or HLA-DPB1, ...

http://emedicine.medscape.com/article/991032-overview

Association of interleukin-4, interleukin-13 gene polymorphisms, HLA-DQ and DR genotypes with genetic susceptibility of type-1 ... HLA-DR Antigens 75% * Genetic Predisposition to Disease 71% * Interleukin-4 64% ...

https://pure.johnshopkins.edu/en/persons/hind-alsharhan

HLA DQ antigen; HLA DRB1 antigen; HLA-DQB1 antigen; lithium; adult; allele; bipolar disorder; female; gene frequency; genetic ... HLA-DQ beta-Chains; HLA-DRB1 Chains; Humans; Lithium; Male; Middle Aged; Pharmacogenetics; Treatment Outcome. [SDGs]SDG3. ... HLA-DRB1 and HLA-DQB1 genetic diversity modulates response to lithium in bipolar affective disorders. ... has recently identified genetic markers associated with treatment responses to Li in the human leukocyte antigens (HLA) region ...

http://scholars.lib.ntu.edu.tw/handle/123456789/583721

Human leukocyte antigen (HLA)-DQ genotyping was performed by polymerase chain reaction on archived tissue. Celiac disease ... Combining HLA-DQ-gluten tetramers with mass cytometry and RNA sequencing analysis, we find that gluten-specific CD4+ T cells in ... Doença Celíaca/genética , Colágeno/análise , Espru Colágeno/genética , Enterite/genética , Antígenos HLA-DQ/genética , ... Antígenos HLA-DQ/imunologia , Humanos , Intestino Delgado/efeitos dos fármacos , Intestino Delgado/patologia , Masculino , ...

https://pesquisa.bvsalud.org/portal/?lang=pt&q=mh:Doen%C3%A7a+Cel%C3%ADaca/classifica%C3%A7%C3%A3o

HLA-DQ); myeloid DCs 1 (CD11c, CD1c [BDCA-1], HLA-DR, HLA-DQ, CD4/CD8); myeloid DCs 2 (CD11c, CD141 [BDCA-3], HLA-DQ, HLA-DQ, ... DQα N62) on the DQα-helix and between the methyldopa carboxylic acid and DQβ30 tyrosine (DQβ Y30) on the floor of the cleft. ... New HLA haplotype frequency reference standards: high-resolution and large sample typing of HLA DR-DQ haplotypes in a sample of ... Additive and interaction effects at three amino acid positions in HLA-DQ and HLA-DR molecules drive type 1 diabetes risk. Nat ...

https://www.jci.org/articles/view/97739

Transracial evidence for the influence of the homologous HLA DR-DQ haplotype on transmission of HLA DR4 haplotypes to diabetic ... Park, Y. S., She, J. X., Noble, J. A., Erlich, H. A. & Eisenbarth, G. S., 2001, In: Tissue Antigens. 57, 3, p. 185-191 7 p.. ... Tubulointerstitial nephritis antigen: An extracellular matrix protein that selectively regulates tubulogenesis vs. ...

https://augusta.elsevierpure.com/en/organisations/obstetrics-and-gynecology/publications/?type=%2Fdk%2Fatira%2Fpure%2Fresearchoutput%2Fresearchoutputtypes%2Fcontributiontojournal%2Farticle&ordering=type&descending=false&page=17

DQ Structure Type Cell surface receptor Quartenary αβ-heterodimer, ligand ... HLA-DQ DQ1 binding pocket with ligand major histocompatibility complex, class II, ... Histocompatibility/Human leukocyte antigen. MHC - MHC class I (HLA-A, HLA-B, HLA-C, HLA-E). MHC class II (HLA-DP, HLA-DQ, HLA- ... There are 9 DQ serotypes:HLA-DQ1, HLA-DQ2, HLA-DQ3, HLA-DQ4, HLA-DQ5, HLA-DQ6, HLA-DQ7, HLA-DQ8, HLA-DQ9. The first identified ...

https://www.chemeurope.com/en/encyclopedia/HLA-DQ.html

The inheritance of HLA-DR antigens differs from that of the HLA-DQ ANTIGENS and HLA-DP ANTIGENS.. ... AntigensAntigens, CDAntigens, CD8Antigens, NeoplasmAntigens, CD3Antigens, SurfaceAntigens, BacterialAntigens, CD38Antigens, ... AntigensAntigens, CDAntigens, CD8Antigens, NeoplasmAntigens, CD3Antigens, SurfaceAntigens, BacterialAntigens, CD38Antigens, ... C-TypeAntigens, CD58Antigens, CD4Antigens, CD47Antigens, CD11bProstate-Specific AntigenAntigens, CD11cO AntigensHLA-A2 Antigen ...

https://lookformedical.com/en/search/antigens-cd137

Genetic response to an environmental pathogenic agent: HLA-DQ and onchocerciasis in northwestern Ecuador. Tissue antigens 2011 ... Query Trace: Onchocerciasis and HLA-DQA1[original query]. ...

https://phgkb.cdc.gov/PHGKB/searchSummary.action?firstQuery=Onchocerciasis+and+HLA-DQA1&Mysubmit=search

This group of antigens includes the -DR, -DQ and -DP designations, of which HLA-DR is most studied; some of these glycoproteins ... Antigens, HLA-D Class II Human Antigens HLA-D HLA-Dw HLA-Dw Antigens Human Class II Antigens Ia-Like Antigens, Human Immune ... HLA-C Antigens [D23.050.301.500.450.390] * HLA-D Antigens [D23.050.301.500.450.400] * HLA-DP Antigens [D23.050.301.500.450.400. ... HLA-C Antigens [D23.050.705.552.450.390] * HLA-D Antigens [D23.050.705.552.450.400] * HLA-DP Antigens [D23.050.705.552.450.400. ...

https://meshb-prev.nlm.nih.gov/record/ui?ui=D006681

HLA-DQ Antigens, Y Chromosome ... PCR of an HLA-DQ-A sequence was used to quantitate residual ... HLA-DQ-A PCR quantitation of a dilution series from 8 to 16,700 per mL of WBCs spiked into double-filtered RBCs showed linear ...

https://biolincc.nhlbi.nih.gov/publications/82cd4e87825e488c99992c28a9f7c9b0

Human Leukocyte Antigen DQ (HLA-DQ) genotypes and haplotypes and their association with phenotype in patients with celiac ... Human leukocyte antigen (HLA)-DQ2 and -DQ8 haplotypes in celiac, celiac with type 1 diabetic, and celiac suspected pediatric ... HLA-DQ genotype distribution and risk evaluation of celiac disease in Northwest China. Scandinavian journal of gastroenterology ... Human Leukocyte Antigen-DQ Genotyping in Pediatric Celiac Disease. Pediatric gastroenterology, hepatology & nutrition 2023 2 26 ...

https://phgkb.cdc.gov/PHGKB/searchSummary.action?firstQuery=Celiac%20Disease+and+HLA-E&Mysubmit=Search

... based on the Human Leukocyte Antigens (HLA) DR1, DQ, DR3, DR4, DR5. Dr. Shoemaker has created a "Rosetta stone" document to ... High-Risk HLA Haplotypes. Unfortunately, the CD4+CD25+ "off switch" doesnt always engage, especially in those with susceptible ... When HLA-susceptible individuals are triggered, the off switch wont properly engage and autoimmunity develops-similar, but ... lack of recognition of the transition from acute infection to chronic inflammation due to a malfunctioning immune system in HLA ...

https://appwell.net/cirs-treatment-steps/

Immunogenetics in PSC II III I Class HLA B C A DP DQ DR CD4 Th2 CD4 Antigens Th0 CD4 Antigen Th1 Presenting NK Cell CD8 CD8 CTL ... Immunogenetics in PSC II III I Class HLA B C A DP DQ DR CD4 Susceptibility Th2 CD4 Antigens Th0 CD4 Antigen Th1 Presenting NK ... Immunogenetics in PSC II III I Class HLA B C A DP DQ DR C4, 2, C4AQ0, MICA, HSPs, TNF α/β Antigen Antigen ... antigens) � Presentation of antigens by HLA molecules to T cells and B cells � Activation of T and B cells to antigens ...

https://www.sambuz.com/doc/immunology-of-primary-sclerosing-cholangitis-ppt-presentation-12317

... mainly in the HLA-DR and HLA-DQ molecules, has been intensely studied. However, less is known about HLA-DP molecules. ... Human leukocyte antigen (HLA) plays a pivotal role in the immune response against HBV infection. The complexes of HLA class I ... HLA class II molecules are classified into three isotypes: HLA-DR, -DQ, and -DP. The importance of polymorphic residues in HBV ... We found differences between Uyghur UC patients and healthy controls, in whom HLA-DRB1*04, HLA-DRB1*13 and HLA-DRB1*14 showed a ...

https://casr-signal.com/2016/02

PATIENTS: HLA-DQ2+ individuals with CD and healthy controls. METHODS: Subjects consumed 20 g of gluten daily for three days. ... RESULTS: In 50/59 CD subjects, irrespective of homo- or heterozygosity for HLA-DQ2, IFN-gamma ELISPOT responses for an optimal ... and were HLA-DQ2 restricted. Peripheral blood T cells specific for A-gliadin 57-73 Q-E65 are rare in untreated CD but can be ... AIMS: To determine the contribution of a putative dominant T cell epitope to the overall gliadin T cell response in HLA-DQ2 CD ...

https://www.immunology.ox.ac.uk/publications/53849?38ddd900-0075-11ee-bfff-061b866677b4

At least two specific combinations of HLA gene variants (HLA haplotypes) have been found to increase the risk of developing celiac disease, a disorder in which inflammation damages the intestinal tract and other organs and tissues. (medlineplus.gov)
One of these haplotypes, known as DQ2, is composed of the protein produced from HLA-DQB1 gene variants known as HLA-DQB1*02:01 or HLA-DQB1*02:02 bound to the protein produced from HLA-DQA1 gene variants known as HLA-DQA1*05:01 or HLA-DQA1*05:05 . (medlineplus.gov)
Type 1 diabetes risk is most increased by two HLA haplotypes involving variations of the HLA-DQA1 and HLA-DQB1 genes and another HLA gene called HLA-DRB1 . (nih.gov)
Other HLA haplotypes only mildly increase the risk of type 1 diabetes, while some haplotypes seem to protect against developing this condition. (nih.gov)
HLA-DQ1 is a serotype that covers a broad range of HLA-DQ haplotypes. (creativebiomart.net)
The frequency of HLA-DQ2/DQ8 haplotypes and celiac disease among the first-degree relatives of patients with celiac disease. (cdc.gov)
Human leukocyte antigen (HLA)-DQ2 and -DQ8 haplotypes in celiac, celiac with type 1 diabetic, and celiac suspected pediatric cases. (cdc.gov)
Human Leukocyte Antigen DQ (HLA-DQ) genotypes and haplotypes and their association with phenotype in patients with celiac disease in India. (cdc.gov)
Unfortunately, the CD4+CD25+ "off switch" doesn't always engage, especially in those with susceptible genotypes/haplotypes (based on the Human Leukocyte Antigens (HLA) DR1, DQ, DR3, DR4, DR5. (appwell.net)

A diabetes-susceptible HLA haplotype is best defined by a combination of HLA-DR and -DQ alleles. (nih.gov)
Relationship of type 1 diabetes to ancestral proportions and HLA DR/DQ alleles in a sample of the admixed Cuban population. (nih.gov)
HLA-DQB1 alleles may influence the surface expression of DQ molecules in lymphomononuclear cells of type 1 diabetes mellitus patients. (nih.gov)
Molecular properties of HLA-DQ alleles conferring susceptibility to or protection from insulin-dependent diabetes mellitus: keys to the fate of islet beta-cells. (nih.gov)
Here we performed the most extensive study investigating the contribution of HLA alleles (i.e. (nih.gov)
Researchers have identified hundreds of different versions (alleles) of the HLA-DQB1 gene, each of which is given a particular number (such as HLA-DQB1*06:02 ). (medlineplus.gov)
36. Specific overexpression of rheumatoid arthritis-associated HLA-DR alleles and presentation of low-affinity peptides. (nih.gov)
To better understand the molecular mechanisms underlying this association, we have genetically imputed the classical alleles of the HLA region in the European patients of the ConLiGen cohort. (ntu.edu.tw)

1. Varying expression of major histocompatibility complex antigens on human renal endothelium and epithelium. (nih.gov)
2. Localization of major histocompatibility complex (HLA-ABC and DR) antigens in 46 kidneys. (nih.gov)
5. The immunohistochemical demonstration of major histocompatibility antigens in the human kidney using monoclonal antibodies. (nih.gov)
10. [Expression of class I and class II histocompatibility antigens in inflammatory kidney diseases]. (nih.gov)
13. Thymoma epithelial cells secrete thymic hormone but do not express class II antigens of the major histocompatibility complex. (nih.gov)
15. Sequential analysis of monomorphic and polymorphic major histocompatibility complex antigen expression in human heart allograft biopsy specimens. (nih.gov)
The HLA complex is the human version of the major histocompatibility complex (MHC), a gene family that occurs in many species. (medlineplus.gov)
HLA is encoded by genes in the major histocompatibility complex on chromosome 6. (who.int)
Histocompatibility antigens in a population based silicosis series. (cdc.gov)
CD8 antigens are members of the immunoglobulin supergene family and are associative recognition elements in MHC (Major Histocompatibility Complex) Class I-restricted interactions. (lookformedical.com)

The involvement of HLA-B62 and HLA-DQ8 in CRPS with dystonia may indicate that these HLA loci are implicated in the susceptibility or expression of the disease. (nih.gov)
The frequencies of the tested HLA loci were determined by direct counting. (who.int)
We have studied the incidence of HLA A, B, C, DR and DQ loci antigen in Rh (D) antigen isoimmunized mothers compared to those nonimmunized isoimmunized Rh negative mothers. (ias.ac.in)
DQ loci are in the "D" region, which encodes DR, DP, and DQ proteins. (chemeurope.com)
High-resolution genotyping of HLA class I loci in children with type 1 diabetes and celiac disease. (cdc.gov)

These children, who carry specific human leukocyte antigen (HLA)-DQ genotypes conferring increased susceptibility to type 1 diabetes, were observed from birth for the appearance of diabetes-associated antibodies and viral infections. (cdc.gov)

The genes that confer actions, are likely to provide important information susceptibility to IDDM are located in the HLA region regarding the causes of IDDM and lead to approaches of chromosome 6. (nih.gov)

The protein produced from the HLA-DQB1 gene attaches (binds) to the protein produced from another MHC class II gene, HLA-DQA1 . (medlineplus.gov)
Clone L243 binds a conformational epitope on HLA-DRa which depends on the correct folding of the aß heterodimer. (biolegend.com)
Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. (nih.gov)
When antigen binds to the T-cell receptor, the CD3 complex transduces the activating signals to the cytoplasm of the T-cell. (lookformedical.com)
A membrane glycoprotein and differentiation antigen expressed on the surface of T-cells that binds to CD40 ANTIGENS on B-LYMPHOCYTES and induces their proliferation. (lookformedical.com)

The HLA-DQB1 gene is part of a family of genes called the human leukocyte antigen (HLA) complex. (medlineplus.gov)
The HLA-DQB1 gene belongs to a group of MHC genes called MHC class II. (medlineplus.gov)
Most people who have narcolepsy with cataplexy have the HLA-DQB1*06:02 variation, and many also have specific versions of other, closely related HLA genes (including HLA-DQA1 ). (medlineplus.gov)
However, these variations are very common in the general population, and only a small percentage of people with particular variations in HLA genes develop narcolepsy. (medlineplus.gov)
HLA genes offer information into the factors driving sarcoidosis and prognosticating tools. (who.int)
Combinations of variations in the HLA-DQA1 gene and other HLA genes affect the risk of type 1 diabetes. (nih.gov)
Single institutions or consortia of institutions are invited to participate in a cooperative research group to define the association between human leukocyte antigen (HLA) region genes or genetic markers and immune-mediated diseases, including risk and severity of disease, and organ, tissue, and cell transplantation outcomes. (nih.gov)
The variants are encoded by the HLA DQ genes and are the result of single nucleotide polymorphisms (SNP). (chemeurope.com)
Low-Risk Human Leukocyte Antigen Genes and Mild Villous Atrophy Typify Celiac Disease With Immunoglobulin A Deficiency. (cdc.gov)

IL-28B and HLA class II are independently associated with spontaneous resolution of HCV infection, and SNPs marking IL-28B and DQB1*03:01 may explain approximately 15% of spontaneous resolution of HCV infection. (nih.gov)
The objectives of the present study were to determine whether the month-of-birth pattern would (a) vary with the presence and severity of cataplexy and (b) differ for patients positive and negative for HLA-DQB1*0602. (nih.gov)
The month-of-birth pattern was similar for HLA-DQB1*0602 positive and negative patients. (nih.gov)
A March birth and HLA-DQB1*0602 positivity were independent risk factors in a logistic regression analysis. (nih.gov)
HLA DQB1*0602 is associated with cataplexy in 509 narcoleptic patients. (nih.gov)
HLA-A, HLA-B, HLA-DRB1, and HLA-DQB1) in 150 CRPS patients who also had fixed dystonia. (nih.gov)
The HLA-DQB1 gene provides instructions for making a protein that plays a critical role in the immune system. (medlineplus.gov)
The other haplotype, known as DQ8, is composed of the protein produced from the HLA-DQB1 gene variant known as HLA-DQB1*03:02 bound to the protein produced from HLA-DQA1 gene variants known as HLA-DQA1*03:01 or HLA-DQA1*03:02 . (medlineplus.gov)
A version of the HLA-DQB1 gene called HLA-DQB1*06:02 increases the risk of developing the sleep disorder narcolepsy, particularly in people who also have cataplexy. (medlineplus.gov)
It is unclear how HLA-DQB1*06:02 causes this elevated risk. (medlineplus.gov)
Phenotype frequencies of HLA-A, B and C and DQB1 and DRB1 were calculated for 51 consecutive patients with biopsy-proven sarcoidosis attending the respiratory clinic at Charlotte Maxeke Johannesburg Academic Hospital and 63 controls, who were potential organ donors. (who.int)
However, the etiology the DQ chain (DQB1*non-Asp-57) are known to be of this disorder remains unclear. (nih.gov)
HLA-DQB1 involved in several pathways and played different roles in them. (creativebiomart.net)
We selected most pathways HLA-DQB1 participated on our site, such as Phagosome, Cell adhesion molecules (CAMs), Antigen processing and presentation, which may be useful for your reference. (creativebiomart.net)
Also, other proteins which involved in the same pathway with HLA-DQB1 were listed below. (creativebiomart.net)
HLA-DQB1 has several biochemical functions, for example, MHC class II receptor activity, peptide antigen binding. (creativebiomart.net)
Some of the functions are cooperated with other proteins, some of the functions could acted by HLA-DQB1 itself. (creativebiomart.net)
The DQα subunit is encoded by the HLA-DQA1 gene and the DQβ subunit is encoded by the HLA-DQB1 gene. (chemeurope.com)

HLA-DR/DQ) antigens and proliferative nuclear antigen. (nih.gov)
Proliferating Cell Nuclear Antigen (PCNA) is an essential protein that participates in a variety of processes of DNA metabolism, including DNA replication and repair, chromatin organization and transcription and sister chromatid cohesion. (eurekaselect.com)
Tan, E.M. Autoantibody to a nuclear antigen in proliferating cells. (eurekaselect.com)
Woloschak, G.E. Proliferating cell nuclear antigen (PCNA): ringmaster of the genome. (eurekaselect.com)
Hübscher, U. Proliferating cell nuclear antigen (PCNA): a dancer with many partners. (eurekaselect.com)
Cassatella, M.A. Proliferating cell nuclear antigen acts as a cytoplasmic platform controlling human neutrophil survival. (eurekaselect.com)
Lee, H. Proliferating cell nuclear antigen in the cytoplasm interacts with components of glycolysis and cancer. (eurekaselect.com)

21. Effects of infliximab therapy on gene expression levels of tumor necrosis factor alpha, tristetraprolin, T cell intracellular antigen 1, and Hu antigen R in patients with rheumatoid arthritis. (nih.gov)
31. The MHC class II transactivator (CIITA) mRNA stability is critical for the HLA class II gene expression in myelomonocytic cells. (nih.gov)
Certain normal variations of the HLA-DQA1 gene have been associated with increased risk of autoimmune disorders, which occur when the immune system malfunctions and attacks the body's own tissues and organs. (nih.gov)
It is unclear how different versions of the HLA-DQA1 gene influence the risk of developing autoimmune disorders. (nih.gov)
In the illustration on the right, DQ1 serotyping antibodies recognizes the DQ alpha (magenta), where antibodies to DQA1* gene products bind variable regions close to the peptide binding pocket. (creativebiomart.net)
In addition 45 unrelated individuals from the same population were typed for HLA DRB and DQB gene using PCR-SSP kits. (ias.ac.in)
This gene belongs to the HLA class II alpha chain family. (antibodies-online.com)

6. In situ characterization of autoimmune phenomena and expression of HLA molecules in the pancreas in diabetic insulitis. (nih.gov)
In conjunction with the CD3/TCR complex and CD4 molecules, HLA-DR is critical for efficient peptide presentation to CD4 + T cells. (biolegend.com)
The L243 monoclonal antibody reacts with the HLA-DR antigen, a member of MHC class II molecules. (biolegend.com)
Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. (nih.gov)
Class II molecules are expressed in antigen presenting cells (B lymphocytes, dendritic cells, macrophages) and are used to present antigenic peptides on the cell surface to be recognized by CD4 T-cells. (antibodies-online.com)

Alanine or Leucine at position 74 of the HLA-DRB1 heavy chain was associated with a good response while Arginine or Glutamic acid with a poor response. (ntu.edu.tw)

HLA-DR is a heterodimeric cell surface glycoprotein comprised of a 36 kD α (heavy) chain and a 27 kD β (light) chain. (biolegend.com)

The study supported the association of HLA antigens with sarcoidosis and implies that there is a genetic predisposition to sarcoidosis in the SA population. (who.int)

A group of the D-related HLA antigens found to differ from the DR antigens in genetic locus and therefore inheritance. (nih.gov)
Grupo de antígenos HLA (humanos) relacionados con D que difieren de los antígenos DR en el locus genético, y por tanto en la herencia. (bvsalud.org)

23. Interleukin-10 inhibits the capacity of synovial macrophages to function as antigen-presenting cells. (nih.gov)
The MHC Class II antigens are found on antigen presenting cells (APC) (macrophages, dendritic cells, and B-lymphocytes). (chemeurope.com)
Alternatively, macrophages and other megalocytes consume cells by apoptotic signaling and present self-antigens. (chemeurope.com)

HLA DQ functions as a cell surface receptor for foreign or self antigens. (chemeurope.com)
Self antigens, in the right context, form a suppressor T-cell population that protects self tissues from immune attack or autoimmunity. (chemeurope.com)

These antigens are polymorphic glycoproteins comprising alpha and beta chains and are found on lymphoid and other cells, often associated with certain diseases. (nih.gov)
We previously identified LB-PTK2B-1T as HLA class II restricted polymorphic antigen in a patient treated with donor lymphocyte infusion for relapsed chronic myeloid leukemia after HLA-matched alloSCT. (haematologica.org)
We previously identified 5 HLA class II restricted polymorphic antigens as targets for allo-reactive CD4 T cells in a patient with relapsed chronic myeloid leukemia who responded to donor lymphocyte infusion (DLI) after HLA-matched alloSCT. (haematologica.org)

There is some evidence that the human leukocyte antigen (HLA) system plays a role in the pathophysiology of CRPS, but previous studies lacked power. (nih.gov)
3. Localization of HLA-ABC and DR antigens in human kidney. (nih.gov)
4. The distribution of HLA antigens on human corneal tissue. (nih.gov)
9. Interferon-gamma modulates HLA class II antigen expression on cultured human thymic epithelial cells. (nih.gov)
12. [Kinetics of serum soluble HLA-A, B and DR antigens on human renal allografts]. (nih.gov)
17. Zonal variation of HLA expression on human cornea epithelium. (nih.gov)
18. Aortic valve allograft structural deterioration is associated with a subset of antibodies to human leukocyte antigens. (nih.gov)
33. IL-1 alpha induced, TNF alpha mediated HLA class II (DR) antigen up-regulation in a human ductal breast carcinoma cell line ZR-75-1. (nih.gov)
Association of human leukocyte antigen donor-recipient matching and pediatric heart transplant graft survival. (musc.edu)
Effect of human leukocyte antigen-C and -DQ matching on pediatric heart transplant graft survival. (musc.edu)
A GWAS performed by the International Consortium on Lithium Genetics (ConLiGen) has recently identified genetic markers associated with treatment responses to Li in the human leukocyte antigens (HLA) region. (ntu.edu.tw)
Find HLA-DQA2 ELISA Kits for a variety of species such as anti-Cow HLA-DQA2, anti-Human HLA-DQA2. (antibodies-online.com)
HLA-DQA2 Monoclonal antibody specifically detects HLA-DQA2 in Human samples. (fishersci.no)
Human recombinant protein fragment corresponding to amino acids 24-125 of human HLA-DQA2 (NP_064440) produced in E.coli. (fishersci.no)
Differentiation antigens expressed on pluripotential hematopoietic cells, most human thymocytes, and a major subset of peripheral blood T-lymphocytes. (lookformedical.com)
In the human population DQ is highly variable, the β subunit more so than the alpha chain. (chemeurope.com)
Human Leucocyte Antigen Genotyping in Celiac Disease: Reasons for Inappropriate Use. (cdc.gov)

HLA Genotyping in Romanian Adult Patients with Celiac Disease, their First-degree Relatives and Healthy Persons. (cdc.gov)
Celiac disease in pediatric patients according to HLA genetic risk classes: a retrospective observational study. (cdc.gov)
TagSNP approach for HLA risk allele genotyping of Saudi celiac disease patients: effectiveness and pitfalls. (cdc.gov)

Together, they form a functional protein complex called an antigen-binding DQαβ heterodimer. (medlineplus.gov)
While this mechanism might seemingly imply that host protein incorporation is a passive uptake of all cellular antigens associated with the plasma membrane at the site of budding, this is not the case. (mdpi.com)
HLA-DQ (DQ) is a cell surface type protein found on antigen presenting cells. (chemeurope.com)
Others result in changes in regions that are removed when the proteins is processed to the cell surface, still others result in change in the non-functional regions of the protein, and some changes result in a change of function of the DQ isoform that is produced. (chemeurope.com)

The goal of this RFA is to establish a cooperative research group to conduct research and to generate high quality HLA-disease association data for public use that will be submitted to and maintained by dbMHC, the publically accessible database of MHC genetics housed and maintained by the National Center for Biomedical Information (NCBI) at the National Institutes of Health National Library of Medicine (NLM). (nih.gov)

The HLA complex helps the immune system distinguish the body's own proteins from proteins made by foreign invaders such as viruses and bacteria. (medlineplus.gov)
As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. (nih.gov)
As such, proteins targeted in coordinated T- and B-cell responses may represent a class of immunodominant antigens in clinical responses after alloSCT. (haematologica.org)

27. Increased HLA-DR and CD44 antigen expression in the gut: evidence of extraarticular immunological activity in rheumatoid arthritis. (nih.gov)
CD44 antigens are the principle cell surface receptors for hyaluronate and this interaction mediates binding of lymphocytes to high endothelial venules. (lookformedical.com)

No perturbations in D-region antigen frequencies were detected. (cdc.gov)

DQ is made up of two different subunits to form an αβ-heterodimer. (chemeurope.com)

37. Endothelial permeability is increased by the supernatant of peripheral blood mononuclear cells stimulated with HLA Class II antibody. (nih.gov)
They were interviewed for symptoms and occupational history and gave a blood specimen for HLA-A, -B, -DR, and -DQ typing and for antinuclear antibody, immune complexes, immunoglobulins, and rheumatoid factor. (cdc.gov)
Overcoming HLA-DPB1 donor specific antibody-mediated haematopoietic graft failure. (musc.edu)
To our knowledge, this is the first description of a coordinated allo-reactive CD4 + T-cell and auto-reactive antibody response against an autosomal antigen. (haematologica.org)

Possible effect of the HLA-DQ2/DQ8 polymorphism on autoimmune parameters and lymphocyte subpopulation in recurrent pregnancy losses. (cdc.gov)

Costimulatory T-LYMPHOCYTE receptors that have specificity for CD80 ANTIGEN and CD86 ANTIGEN. (lookformedical.com)

We investigated whether islet autoantibody profile, HLA-DQ genotype, and age influenced a 20-year progression to diabetes from first autoantibody positivity (autoAb + ) in first-degree relatives of patients with type 1 diabetes. (diabetesgeneeskunde.nl)

Complex of at least five membrane-bound polypeptides in mature T-lymphocytes that are non-covalently associated with one another and with the T-cell receptor (RECEPTORS, ANTIGEN, T-CELL). (lookformedical.com)
The CD3 gamma and delta chains (subunits) are separate from and not related to the gamma/delta chains of the T-cell receptor (RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA). (lookformedical.com)
Normally, these APC 'present' class II receptor/antigens to a great many T-cells, each with unique T-cell receptor (TCR) variants. (chemeurope.com)

Donor-reactive HLA antibodies in renal allograft recipients: considerations, complications, and conundrums. (musc.edu)

7. Anti-HLA-A, B, C and DR antibodies in renal transplant recipients. (nih.gov)

A few TCR variants that recognize these DQ/antigen complexes are on CD4 positive (CD4+) T-cells. (chemeurope.com)
Immune complexes may subsequently be processed and presented by professional antigen presenting cells and stimulate induction of specific CD8 + T cells. (haematologica.org)

As these variants have been implicated in common inflammatory/autoimmune processes, our findings strongly suggest that HLA-mediated low inflammatory background may contribute to the efficient response to Li in BD patients, while an inflammatory status overriding Li anti-inflammatory properties would favor a weak response. (ntu.edu.tw)

The immune system surveys antigens for foreign pathogens when presented by MHC receptors (like HLA DQ). (chemeurope.com)

Nomenclature for factors of the HLA system 1984. (ox.ac.uk)

These surface cel s are important in presentation of antigen and play a key part in the body's immune response to external antigens. (who.int)
Variances in vulnerability, presentation, progression and prognosis have been related to different HLA phenotypes. (who.int)

This region encoded the subunits for DP,-Q and -R which are the major MHC class II antigens in humans. (chemeurope.com)

19. Classes I and II HLA and melanoma-associated antigen expression and modulation on melanoma cells isolated from primary and metastatic lesions. (nih.gov)
22. HLA DR, DQ, and DP antigen expression in rheumatoid synovial cells: a biochemical and quantitative study. (nih.gov)
Antigens on surfaces of cells, including infectious or foreign cells or viruses. (lookformedical.com)
Generally found on antigen presenting cells, is an antigen presenting molecule. (chemeurope.com)
These T-cells, called T-helper cells, can promote the amplification of B-cells which, in turn recognize a different portion of the same antigen. (chemeurope.com)
During this treatment, patient hematopoiesis is eradicated by high-dose radio-/chemotherapy and the patient is rescued by infusion of hematopoietic stem cells of an (HLA-matched) donor. (haematologica.org)
7 Although the capacity of CD4 T cells to stimulate production of antibodies is well-known, and induction of auto- and allo-reactive antibodies after HLA-matched alloSCT has been demonstrated by various studies, 8 - 15 the link between CD4 T- and B-cell immunity after alloSCT has only been demonstrated for DDX3Y, a male specific antigen encoded on the Y-chromosome. (haematologica.org)

When HLA-susceptible individuals are triggered, the off switch won't properly engage and autoimmunity develops-similar, but different to Systemic Lupus Erythromatosis (SLE), Rheumatoid Arthritis, etc. (appwell.net)

CD stands for cluster of differentiation, which refers to groups of monoclonal antibodies that show similar reactivity with certain subpopulations of antigens of a particular lineage or differentiation stage. (lookformedical.com)

Differences in HLA-DR staining of tubules among kidneys. (nih.gov)

Thus in the present study it is evident that the inheritance of HLA A3, B17, Cw2 and DR4 increases the relative risk factor by 2.6 times among Indian Rh isoimmunized women. (ias.ac.in)

HLA-DQ (DQ) is encoded on the HLA region of chromosome 6, in what was classically known as the "D" antigen region. (chemeurope.com)

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Analytical, Diagnostic and Therapeutic Techniques and Equipment5

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Health Care1

Class II HLA alleles and hepatitis B virus persistence in African Americans. (1/1046)

MHC class II gene associations with autoantibodies to U1A and SmD1 proteins. (2/1046)

Immune responses against human papillomavirus (HPV) type 16 virus-like particles in a cohort study of women with cervical intraepithelial neoplasia. I. Differential T-helper and IgG responses in relation to HPV infection and disease outcome. (3/1046)

Major DQ8-restricted T-cell epitopes for human GAD65 mapped using human CD4, DQA10301, DQB10302 transgenic IA(null) NOD mice. (4/1046)

Inhibition of allorecognition by a human class II MHC-derived peptide through the induction of apoptosis. (5/1046)

Influence of ethnic background on clinical and serologic features in patients with systemic sclerosis and anti-DNA topoisomerase I antibody. (6/1046)

Analysis of MHC class II DP, DQ and DR alleles in Crohn's disease. (7/1046)

Generation of humanized mice susceptible to peptide-induced inflammatory heart disease. (8/1046)

No images available that match "hla dq antigens"

HLA-DQ Antigens

HLA Antigens

Celiac Disease

HLA-DR Antigens

Antigens

Antigens, Bacterial

Antigens, Neoplasm

Antigens, Surface

Antigens, Viral

Antigens, Protozoan

Antigens, Polyomavirus Transforming

Histocompatibility Antigens Class II

Antigens, CD

Antigens, Fungal

HLA-D Antigens

HLA-B Antigens

H-2 Antigens

HLA-A Antigens

Antigens, Helminth

Histocompatibility Antigens Class I

Carcinoembryonic Antigen

Epitopes

Antigens, Viral, Tumor

Antibodies, Monoclonal

HLA-DR3 Antigen

Histocompatibility Antigens

Receptors, Antigen, T-Cell

HLA-A2 Antigen

Histocompatibility Testing

HLA-DQ beta-Chains

T-Lymphocytes

Proliferating Cell Nuclear Antigen

Receptors, Antigen, B-Cell

Prostate-Specific Antigen

O Antigens

Molecular Sequence Data

HLA-DR4 Antigen

Antigens, CD8

Antigens, CD15

Enzyme-Linked Immunosorbent Assay

Antigens, Tumor-Associated, Carbohydrate

HLA-DRB1 Chains

Cross Reactions

Immunoglobulin G

Lymphocyte Activation

HLA-DP Antigens

Amino Acid Sequence

Genes, MHC Class II

Antigens, CD3

HLA-C Antigens

Hepatitis B Surface Antigens

Blood Group Antigens

HLA-DQ alpha-Chains

Antibody Specificity

Alleles

Mice, Inbred BALB C

Cell Line

Antigens, CD4

B-Lymphocytes

Fluorescent Antibody Technique

Antigens, CD45

Major Histocompatibility Complex

Receptors, Antigen

Hepatitis B Antigens

Antigen-Antibody Reactions

T-Lymphocytes, Cytotoxic

Immunization

Antibody Formation

Antigens, CD1

Antigens, Differentiation

HLA-B8 Antigen

Immune Sera

Antibodies, Bacterial

HLA-B7 Antigen

HLA-B27 Antigen

Genes, MHC Class I

Autoantigens

HIV Antigens

Class II HLA alleles and hepatitis B virus persistence in African Americans. (1/1046)

MHC class II gene associations with autoantibodies to U1A and SmD1 proteins. (2/1046)

Major DQ8-restricted T-cell epitopes for human GAD65 mapped using human CD4, DQA10301, DQB10302 transgenic IA(null) NOD mice. (4/1046)