The degree of antigenic similarity between the tissues of different individuals, which determines the acceptance or rejection of allografts.
Antigens determined by leukocyte loci found on chromosome 6, the major histocompatibility loci in humans. They are polypeptides or glycoproteins found on most nucleated cells and platelets, determine tissue types for transplantation, and are associated with certain diseases.
Genetic loci responsible for the encoding of histocompatibility antigens other than those encoded by the MAJOR HISTOCOMPATIBILITY COMPLEX. The antigens encoded by these genes are often responsible for graft rejection in cases where histocompatibility has been established by standard tests. The location of some of these loci on the X and Y chromosomes explains why grafts from males to females may be rejected while grafts from females to males are accepted. In the mouse roughly 30 minor histocompatibility loci have been recognized, comprising more than 500 genes.
A bibliographic database that includes MEDLINE as its primary subset. It is produced by the National Center for Biotechnology Information (NCBI), part of the NATIONAL LIBRARY OF MEDICINE. PubMed, which is searchable through NLM's Web site, also includes access to additional citations to selected life sciences journals not in MEDLINE, and links to other resources such as the full-text of articles at participating publishers' Web sites, NCBI's molecular biology databases, and PubMed Central.
A group of antigens that includes both the major and minor histocompatibility antigens. The former are genetically determined by the major histocompatibility complex. They determine tissue type for transplantation and cause allograft rejections. The latter are systems of allelic alloantigens that can cause weak transplant rejection.
Controlled vocabulary thesaurus produced by the NATIONAL LIBRARY OF MEDICINE. It consists of sets of terms naming descriptors in a hierarchical structure that permits searching at various levels of specificity.
Any woven or knit material of open texture used in surgery for the repair, reconstruction, or substitution of tissue. The mesh is usually a synthetic fabric made of various polymers. It is occasionally made of metal.
Glycoproteins expressed on cortical thymocytes and on some dendritic cells and B-cells. Their structure is similar to that of MHC Class I and their function has been postulated as similar also. CD1 antigens are highly specific markers for human LANGERHANS CELLS.
Membrane glycoproteins consisting of an alpha subunit and a BETA 2-MICROGLOBULIN beta subunit. In humans, highly polymorphic genes on CHROMOSOME 6 encode the alpha subunits of class I antigens and play an important role in determining the serological specificity of the surface antigen. Class I antigens are found on most nucleated cells and are generally detected by their reactivity with alloantisera. These antigens are recognized during GRAFT REJECTION and restrict cell-mediated lysis of virus-infected cells.
The genetic region which contains the loci of genes which determine the structure of the serologically defined (SD) and lymphocyte-defined (LD) TRANSPLANTATION ANTIGENS, genes which control the structure of the IMMUNE RESPONSE-ASSOCIATED ANTIGENS, HUMAN; the IMMUNE RESPONSE GENES which control the ability of an animal to respond immunologically to antigenic stimuli, and genes which determine the structure and/or level of the first four components of complement.
The process by which antigen is presented to lymphocytes in a form they can recognize. This is performed by antigen presenting cells (APCs). Some antigens require processing before they can be recognized. Antigen processing consists of ingestion and partial digestion of the antigen by the APC, followed by presentation of fragments on the cell surface. (From Rosen et al., Dictionary of Immunology, 1989)
A major histocompatibily complex class I-like protein that plays a unique role in the presentation of lipid ANTIGENS to NATURAL KILLER T-CELLS.
Large, transmembrane, non-covalently linked glycoproteins (alpha and beta). Both chains can be polymorphic although there is more structural variation in the beta chains. The class II antigens in humans are called HLA-D ANTIGENS and are coded by a gene on chromosome 6. In mice, two genes named IA and IE on chromosome 17 code for the H-2 antigens. The antigens are found on B-lymphocytes, macrophages, epidermal cells, and sperm and are thought to mediate the competence of and cellular cooperation in the immune response. The term IA antigens used to refer only to the proteins encoded by the IA genes in the mouse, but is now used as a generic term for any class II histocompatibility antigen.
A disorder of neuromuscular transmission characterized by weakness of cranial and skeletal muscles. Autoantibodies directed against acetylcholine receptors damage the motor endplate portion of the NEUROMUSCULAR JUNCTION, impairing the transmission of impulses to skeletal muscles. Clinical manifestations may include diplopia, ptosis, and weakness of facial, bulbar, respiratory, and proximal limb muscles. The disease may remain limited to the ocular muscles. THYMOMA is commonly associated with this condition. (Adams et al., Principles of Neurology, 6th ed, p1459)
A neoplasm originating from thymic tissue, usually benign, and frequently encapsulated. Although it is occasionally invasive, metastases are extremely rare. It consists of any type of thymic epithelial cell as well as lymphocytes that are usually abundant. Malignant lymphomas that involve the thymus, e.g., lymphosarcoma, Hodgkin's disease (previously termed granulomatous thymoma), should not be regarded as thymoma. (From Stedman, 25th ed)
Autoantibodies directed against various nuclear antigens including DNA, RNA, histones, acidic nuclear proteins, or complexes of these molecular elements. Antinuclear antibodies are found in systemic autoimmune diseases including systemic lupus erythematosus, Sjogren's syndrome, scleroderma, polymyositis, and mixed connective tissue disease.
Tumors or cancer of the THYMUS GLAND.
Any autoimmune animal disease model used in the study of MYASTHENIA GRAVIS. Injection with purified neuromuscular junction acetylcholine receptor (AChR) (see RECEPTORS, CHOLINERGIC) components results in a myasthenic syndrome that has acute and chronic phases. The motor endplate pathology, loss of acetylcholine receptors, presence of circulating anti-AChR antibodies, and electrophysiologic changes make this condition virtually identical to human myasthenia gravis. Passive transfer of AChR antibodies or lymphocytes from afflicted animals to normals induces passive transfer experimental autoimmune myasthenia gravis. (From Joynt, Clinical Neurology, 1997, Ch 54, p3)
Surgical removal of the thymus gland. (Dorland, 28th ed)
A subtype of striated muscle, attached by TENDONS to the SKELETON. Skeletal muscles are innervated and their movement can be consciously controlled. They are also called voluntary muscles.
The largest country in North America, comprising 10 provinces and three territories. Its capital is Ottawa.
A voluntary organization concerned with the prevention and treatment of cancer through education and research.
Transfer of HEMATOPOIETIC STEM CELLS from BONE MARROW or BLOOD between individuals within the same species (TRANSPLANTATION, HOMOLOGOUS) or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS). Hematopoietic stem cell transplantation has been used as an alternative to BONE MARROW TRANSPLANTATION in the treatment of a variety of neoplasms.
Relatively undifferentiated cells that retain the ability to divide and proliferate throughout postnatal life to provide progenitor cells that can differentiate into specialized cells.
Identification of the major histocompatibility antigens of transplant DONORS and potential recipients, usually by serological tests. Donor and recipient pairs should be of identical ABO blood group, and in addition should be matched as closely as possible for HISTOCOMPATIBILITY ANTIGENS in order to minimize the likelihood of allograft rejection. (King, Dictionary of Genetics, 4th ed)
Individuals supplying living tissue, organs, cells, blood or blood components for transfer or transplantation to histocompatible recipients.
Human immune-response or Class II antigens found mainly, but not exclusively, on B-lymphocytes and produced from genes of the HLA-D locus. They are extremely polymorphic families of glycopeptides, each consisting of two chains, alpha and beta. This group of antigens includes the -DR, -DQ and -DP designations, of which HLA-DR is most studied; some of these glycoproteins are associated with certain diseases, possibly of immune etiology.
A group of the D-related HLA antigens found to differ from the DR antigens in genetic locus and therefore inheritance. These antigens are polymorphic glycoproteins comprising alpha and beta chains and are found on lymphoid and other cells, often associated with certain diseases.
A subclass of HLA-D antigens that consist of alpha and beta chains. The inheritance of HLA-DR antigens differs from that of the HLA-DQ ANTIGENS and HLA-DP ANTIGENS.
Theory and development of COMPUTER SYSTEMS which perform tasks that normally require human intelligence. Such tasks may include speech recognition, LEARNING; VISUAL PERCEPTION; MATHEMATICAL COMPUTING; reasoning, PROBLEM SOLVING, DECISION-MAKING, and translation of language.
A specific HLA-B surface antigen subtype. Members of this subtype contain alpha chains that are encoded by the HLA-B*27 allele family.
Class I human histocompatibility (HLA) surface antigens encoded by more than 30 detectable alleles on locus B of the HLA complex, the most polymorphic of all the HLA specificities. Several of these antigens (e.g., HLA-B27, -B7, -B8) are strongly associated with predisposition to rheumatoid and other autoimmune disorders. Like other class I HLA determinants, they are involved in the cellular immune reactivity of cytolytic T lymphocytes.
Substances that are recognized by the immune system and induce an immune reaction.
A specific HLA-B surface antigen subtype. Members of this subtype contain alpha chains that are encoded by the HLA-B*44 allele family.
A specific HLA-B surface antigen subtype. Members of this subtype contain alpha chains that are encoded by the HLA-B*08 allele family.
A specific HLA-B surface antigen subtype. Members of this subtype contain alpha chains that are encoded by the HLA-B*35 allele family.
Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)
Transplantation between individuals of the same species. Usually refers to genetically disparate individuals in contradistinction to isogeneic transplantation for genetically identical individuals.
Transference of an organ between individuals of the same species or between individuals of different species.
The transference of a kidney from one human or animal to another.
Organs, tissues, or cells taken from the body for grafting into another area of the same body or into another individual.
Lists of words, usually in alphabetical order, giving information about form, pronunciation, etymology, grammar, and meaning.
Substances elaborated by bacteria that have antigenic activity.
A specific HLA-A surface antigen subtype. Members of this subtype contain alpha chains that are encoded by the HLA-A*02 allele family.
Polymorphic class I human histocompatibility (HLA) surface antigens present on almost all nucleated cells. At least 20 antigens have been identified which are encoded by the A locus of multiple alleles on chromosome 6. They serve as targets for T-cell cytolytic responses and are involved with acceptance or rejection of tissue/organ grafts.
A specific HLA-A surface antigen subtype. Members of this subtype contain alpha chains that are encoded by the HLA-A*03 allele family.
A specific HLA-A surface antigen subtype. Members of this subtype contain alpha chains that are encoded by the HLA-A*24 allele family.
A specific HLA-A surface antigen subtype. Members of this subtype contain alpha chains that are encoded by the HLA-A*11 allele family.

Thymic selection by a single MHC/peptide ligand: autoreactive T cells are low-affinity cells. (1/790)

In H2-M- mice, the presence of a single peptide, CLIP, bound to MHC class II molecules generates a diverse repertoire of CD4+ cells. In these mice, typical self-peptides are not bound to class II molecules, with the result that a very high proportion of H2-M- CD4+ cells are responsive to the various peptides displayed on normal MHC-compatible APC. We show here, however, that such "self" reactivity is controlled by low-affinity CD4+ cells. These cells give spectacularly high proliferative responses but are virtually unreactive in certain other assays, e.g., skin graft rejection; responses to MHC alloantigens, by contrast, are intense in all assays. Possible explanations for why thymic selection directed to a single peptide curtails self specificity without affecting alloreactivity are discussed.  (+info)

Familial antiphospholipid antibody syndrome: criteria for disease and evidence for autosomal dominant inheritance. (2/790)

OBJECTIVE: To develop diagnostic criteria for a familial form of antiphospholipid antibody syndrome (APS), identify families with >1 affected member, examine possible modes of inheritance, and determine linkage to potential candidate genes. METHODS: Family members of probands with primary APS were analyzed for clinical and laboratory abnormalities associated with APS. Families with > or =2 affected members were analyzed by segregation analysis and typed for candidate genetic markers. RESULTS: Seven families were identified. Thirty of 101 family members met diagnostic criteria for APS. Segregation studies rejected both environmental and autosomal recessive models, and the data were best fit by either a dominant or codominant model. Linkage analysis showed independent segregation of APS and several candidate genes. CONCLUSION: Clinical and laboratory criteria are essential to identify the spectrum of disease associated with APS. We believe a set of criteria was developed that can precisely define affected family members with APS. Modeling studies utilizing these criteria strongly support a genetic basis for disease in families with APS and suggest that a susceptibility gene is inherited in an autosomal dominant pattern. However, in these families, APS was not linked with HLA, Fas, or other candidate genes, including beta2-glycoprotein 1, HLA, T cell receptor beta chain, Ig heavy chain, antithrombin III, Fas ligand, factor V, complement factor H, IgK, and Fas.  (+info)

Opposing motor activities of dynein and kinesin determine retention and transport of MHC class II-containing compartments. (3/790)

MHC class II molecules exert their function at the cell surface by presenting to T cells antigenic fragments that are generated in the endosomal pathway. The class II molecules are targetted to early lysosomal structures, termed MIIC, where they interact with antigenic fragments and are subsequently transported to the cell surface. We previously visualised vesicular transport of MHC class II-containing early lysosomes from the microtubule organising centre (MTOC) region towards the cell surface in living cells. Here we show that the MIIC move bidirectionally in a 'stop-and-go' fashion. Overexpression of a motor head-deleted kinesin inhibited MIIC motility, showing that kinesin is the motor that drives its plus end transport towards the cell periphery. Cytoplasmic dynein mediates the return of vesicles to the MTOC area and effectively retains the vesicles at this location, as assessed by inactivation of dynein by overexpression of dynamitin. Our data suggest a retention mechanism that determines the perinuclear accumulation of MIIC, which is the result of dynein activity being superior over kinesin activity. The bidirectional nature of MIIC movement is the result of both kinesin and dynein acting reciprocally on the MIIC during its transport. The motors may be the ultimate targets of regulatory kinases since the protein kinase inhibitor staurosporine induces a massive release of lysosomal vesicles from the MTOC region that is morphologically similar to that observed after inactivation of the dynein motor.  (+info)

Cellular distribution of a mixed MHC class II heterodimer between DRalpha and a chimeric DObeta chain. (4/790)

Human MHC class II antigens include HLA-DR, -DQ, and -DP molecules that present antigens to CD4+ T cells, as well as the non-classical molecules HLA-DM and -DO. HLA-DM promotes peptide binding to class II molecules in endocytic compartments and HLA-DO, which is physically associated with HLA-DM in B lymphocytes, regulates HLA-DM function. Antibodies specific for the DObeta chain were obtained by immunization of mice with a heterodimer consisting of a chimeric DObeta chain (DR/DObeta), containing 18 N-terminal residues of DRbeta, paired with the DRalpha chain and isolated from transfected murine fibroblasts. The specificity of this serum for the DObeta chain and the lysosomal expression of the HLA-DO protein was confirmed using mutant human B cell lines lacking DR or DO molecules. The lysosomal localization of HLA-DO in human B cells contrasts with the cell surface expression of the mixed pair in transfected murine fibroblasts and raises questions concerning the role of the putative targeting motifs in HLA-DO. Transfection of the chimeric DR/DObeta chain along with DRalpha into human epithelial HeLa cells resulted in high levels of expression of the mixed isotypic pair at the surface of transfectants as well as in lysosomes. The same pattern was observed in HeLa cells transfected with the DObeta chimera and a DRa chain lacking the cytoplasmic tail. Taken together, these results suggest that functional sorting motifs exist in the DObeta chain but that the tight compartmentalization of HLA-DO observed inside B lymphocytes is controlled by the HLA-DOalpha chain and HLA-DM.  (+info)

HLA-DM and invariant chain are expressed by thyroid follicular cells, enabling the expression of compact DR molecules. (5/790)

Thyroid follicular cells (TFC) in Graves' disease (GD) hyperexpress HLA class I and express ectopic HLA class II molecules, probably as a consequence of cytokines produced by infiltrating T cells. This finding led us to postulate that TFC could act as antigen-presenting cells, and in this way be responsible for the induction and/or maintenance of the in situ autoimmune T cell response. Invariant chain (li) and HLA-DM molecules are implicated in the antigen processing and presentation by HLA class II molecules. We have investigated the expression of these molecules by TFC from GD glands. The results demonstrate that class II+ TFC from GD patients also express li and HLA-DM, and this expression is increased after IFN-gamma stimulation. The level of HLA-DM expression by TFC was low but sufficient to catalyze peptide loading into the HLA class II molecules and form stable HLA class II-peptide complexes expressed at the surface of TFC. These results have implications for the understanding of the possible role of HLA class II+ TFC in thyroid autoimmune disease.  (+info)

Phagosomes are fully competent antigen-processing organelles that mediate the formation of peptide:class II MHC complexes. (6/790)

During the processing of particulate Ags, it is unclear whether peptide:class II MHC (MHC-II) complexes are formed within phagosomes or within endocytic compartments that receive Ag fragments from phagosomes. Murine macrophages were pulsed with latex beads conjugated with OVA. Flow or Western blot analysis of isolated phagosomes showed extensive acquisition of MHC-II, H-2M, and invariant chain within 30 min, with concurrent degradation of OVA. T hybridoma responses to isolated subcellular fractions demonstrated OVA (323-339):I-Ad complexes in phagosomes and plasma membrane but not within dense late endocytic compartments. Furthermore, when two physically separable sets of phagosomes were present within the same cells, OVA(323-339):I-Ad complexes were demonstrated in latex-OVA phagosomes but not in phagosomes containing latex beads conjugated with another protein. This implies that these complexes were formed specifically within phagosomes and were not formed elsewhere and subsequently transported to phagosomes. In addition, peptide:MHC-II complexes were shown to traffic from phagosomes to the cell surface. In conclusion, phagosomes are fully competent to process Ags and generate peptide:MHC-II complexes that are transported to the cell surface and presented to T cells.  (+info)

The antigen-presenting environment in normal and human papillomavirus (HPV)-related premalignant cervical epithelium. (7/790)

The activation of HPV-specific T cells within the cervical microenvironment is likely to play an important part in the natural history of cervical intraepithelial neoplasia (CIN). The extent and the type of T cell activation will depend critically on the expression of MHC, costimulatory cell surface molecules and cytokines by keratinocytes and Langerhans cells within the cervical lesion. Expression of MHC class II (HLA-A-DR and -DQ), costimulatory/adhesion molecules (CD11a/18, CD50, CD54, CD58 and CD86) and cytokines (tumour necrosis factor-alpha (TNF-alpha) and IL-10) was therefore investigated by immunohistochemistry in normal squamous epithelium (n = 12), low-grade (n = 23) and high-grade (n = 18) squamous intraepithelial lesions of the cervix. CIN progression was associated with de novo expression of HLA-DR and CD54, and increased expression of CD58 by keratinocytes. However, significantly, there was no expression of any adhesion/costimulation molecule by epithelial Langerhans cells in any cervical biopsy studied. Furthermore, TNF-alpha, a potent activator of Langerhans cells, was expressed constitutively by basal keratinocytes in normal cervix (12+/12). but expression of this cytokine was absent in a number of CIN samples (20+/23 for low-grade, 12+/18 for high-grade CIN). Conversely, the suppressive cytokine IL-10 was absent in normal epithelium (0+/12), but was up-regulated in a number of CIN lesions (12+/23 for low-grade; 8+/18 for high-grade CIN). The restricted expression of costimulation/adhesion molecules and the nature of the cytokine microenvironment within the epithelium may act to limit effective immune responses in some CIN lesions.  (+info)

HLA-DMB expression by thyrocytes: indication of the antigen-processing and possible presenting capability of thyroid cells. (8/790)

Expression of HLA class II molecules on thyrocytes is a characteristic feature of autoimmune thyroid disease and may lead the thyroid cells to present autoantigens to CD4+ T lymphocytes. Since HLA-DM is a critical molecule in class II-restricted antigen processing and presentation, we assessed the expression of HLA-DMB, -invariant chain (Ii), class II transactivator (CIITA) and DRA in an untransformed, pure thyrocyte strain HTV-59A. Here we report that both HLA-DMB mRNA and the protein are expressed in thyrocytes and that CIITA expression is enhanced by interferon-gamma (IFN-gamma) treatment and occurs before DMB, Ii and DRA up-regulation, suggesting CIITA expression is a requirement for antigen processing in thyrocytes. These results indicate that thyrocytes are capable of antigen processing and possibly antigen presentation to T cells.  (+info)

Shop Mamu class II histocompatibility antigen ELISA Kit, Recombinant Protein and Mamu class II histocompatibility antigen Antibody at MyBioSource. Custom ELISA Kit, Recombinant Protein and Antibody are available.
Reactome is pathway database which provides intuitive bioinformatics tools for the visualisation, interpretation and analysis of pathway knowledge.
Reactome is pathway database which provides intuitive bioinformatics tools for the visualisation, interpretation and analysis of pathway knowledge.
HLA class II expression is notable in rheumatoid arthritis. We have investigated the mechanism of HLA class II regulation in the joints and found local synthesis, as judged by mRNA levels to be high. The role of antigen presentation in maintaining class II mRNA was explored, and blocking presentation by using monoclonal antibodies to HLA class II inhibited synthesis of mRNA for HLA-DR alpha chain. HLA class II expression is maintained by cytokines and so cytokine production in rheumatoid joints was investigated. It was chosen to use mRNA analysis by slot blotting as a screening assay, and the expression of many cytokines was detected. Levels of these were maintained in culture in the absence of extrinsic stimulation.
Mouse monoclonal antibody raised against a partial recombinant HLA-DMB. HLA-DMB (NP_002109, 22 a.a. ~ 129 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. (H00003109-M09) - Products - Abnova
Order HLA-DMB ELISA Kits for many Reactivities. and more. Compare HLA-DMB ELISA Kits and find the right product on antibodies-online.com.
The PDB archive contains information about experimentally-determined structures of proteins, nucleic acids, and complex assemblies. As a member of the wwPDB, the RCSB PDB curates and annotates PDB data according to agreed upon standards. The RCSB PDB also provides a variety of tools and resources. Users can perform simple and advanced searches based on annotations relating to sequence, structure and function. These molecules are visualized, downloaded, and analyzed by users who range from students to specialized scientists.
The PDB archive contains information about experimentally-determined structures of proteins, nucleic acids, and complex assemblies. As a member of the wwPDB, the RCSB PDB curates and annotates PDB data according to agreed upon standards. The RCSB PDB also provides a variety of tools and resources. Users can perform simple and advanced searches based on annotations relating to sequence, structure and function. These molecules are visualized, downloaded, and analyzed by users who range from students to specialized scientists.
T-cell receptor MHC complex. Computer model showing the structure of a T-cell surface glycoprotein CD4 (purple) complexed to the H-2 class II histocompatibility antigen A-K alpha chain (green) beta chain (yellow) and ovotransferrin (red). CD4 is a receptor found on T-cell white blood cells of the immune system. Antigens (foreign proteins) are presented to T cell receptors by MHC molecules to effect an immune response. - Stock Image C035/5403
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RFX5 antibody (regulatory factor X, 5 (influences HLA class II expression)) for IHC-P, IP, WB. Anti-RFX5 pAb (GTX29255) is tested in Human samples. 100% Ab-Assurance.
Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments.
Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments.
Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route; where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules; and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments; exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides; autophagosomes constitutively fuse with MHC class II loading ...
Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route; where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules; and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments; exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides; autophagosomes constitutively fuse with MHC class II loading ...
HLA class II histocompatibility antigen, DO beta chain is a protein that in humans is encoded by the HLA-DOB gene. HLA-DOB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DOA) and a beta chain (DOB), both anchored in the membrane. It is located in intracellular vesicles. DO suppresses peptide loading of MHC class II molecules by inhibiting HLA-DM. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. ENSG00000241910, ENSG00000243612, ENSG00000239457, ENSG00000241386, ENSG00000241106 GRCh38: Ensembl release 89: ENSG00000243496, ENSG00000241910, ENSG00000243612, ENSG00000239457, ENSG00000241386, ENSG00000241106 - Ensembl, May 2017 ...
HLA class II histocompatibility antigen, DO alpha chain is a protein that in humans is encoded by the HLA-DOA gene. HLA-DOA belongs to the HLA class II alpha chain paralogues. HLA-DOA forms a heterodimer with HLA-DOB. The heterodimer, HLA-DO, is found in lysosomes in B cells and regulates HLA-DM-mediated peptide loading on MHC class II molecules. In comparison with classical HLA class II molecules, this gene exhibits very little sequence variation, especially at the protein level. ENSG00000230141, ENSG00000232962, ENSG00000235744, ENSG00000231558, ENSG00000206292, ENSG00000232957 GRCh38: Ensembl release 89: ENSG00000204252, ENSG00000230141, ENSG00000232962, ENSG00000235744, ENSG00000231558, ENSG00000206292, ENSG00000232957 - Ensembl, May 2017 GRCm38: Ensembl release 89: ENSMUSG00000024334 - Ensembl, May 2017 Human PubMed Reference:. Mouse PubMed Reference:. Young JA, Trowsdale J (Aug 1990). The HLA-DNA (DZA) gene is correctly expressed as a 1.1 kb mature mRNA transcript. Immunogenetics. 31 ...
Large, transmembrane, non-covalently linked Glycoproteins (alpha and beta). Both chains can be polymorphic although there is more structural variation in the beta chains. The class II Antigens in Humans are called HLA-D Antigens and are coded by A Gene on Chromosome 6. In Mice, two Genes named IA and IE on Chromosome 17 code for the H-2 Antigens. The Antigens are found on B-Lymphocytes, Macrophages, epidermal Cells, and Sperm and are thought to mediate the competence of and cellular cooperation in the immune response. The term IA Antigens used to refer only to the Proteins encoded by the IA Genes in the Mouse, but is now used as A Generic term for any class II Histocompatibility Antigen ...
HLA class II histocompatibility antigen, DQ beta 1 chain; Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for pr ...
HLA-DR antigen expression in colorectal carcinomas: influence of expression by IFN-gamma in situ and its association with tumour progression.: The authors attem
Principal nameMHC Class II I-Ak antibodyAlternative names for MHC Class II I-Ak antibodyH2-Aa, H-2 class II histocompatibility antigen A-K alpha…
The step should be no more than (height of gasket - 1) micrometres to enable flow to be maintained. 44 Lawson, Rose, and Wolf A Glassslide EC monolayer Flow flow chamber B Glass slide flow chamber i ii iii iv Fig. 6. Interposition of a step barrier in the primary flow creates defined areas of disturbed flow downstream. (a) Flow in parallel-plate flow chamber. Laminar flow (black arrows) is created by pumping fluid over an endothelial monolayer plated onto a glass coverslip. (b) Interposition of a step barrier creates areas of disturbed flow downstream: (i) flow recirculation, (ii) flow reattachment, (iii) flow recovery and (iv) recovered laminar shear (adapted from (29)). 1997) Species differences in the expression of major histocompatibility complex class II antigens on coronary artery endothelium: implications for cell-mediated xenoreactivity. Transplantation 64, 1315-22. 4. McDouall RM, Page CS, Hafizi S, Yacoub MH, Rose ML. (1996) Alloproliferation of purified CD4+ T cells to adult human ...
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The nascent MHC class II protein in the rough ER has its peptide-binding cleft blocked by the invariant chain (Ii; a trimer) to prevent it from binding cellular peptides or peptides from the endogenous pathway. The invariant chain also facilitates MHC class IIs export from the ER in a vesicle. This fuses with a late endosome containing the endocytosed, degraded proteins. It is then broken down in stages, leaving only a small fragment called CLIP which still blocks the peptide binding cleft. An MHC class II-like structure, HLA-DM, removes CLIP and replaces it with a peptide from the endosome. The stable MHC class-II is then presented on the cell surface ...
RefSeq Summary (NM_006120): HLA-DMA belongs to the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta chain (DMB), both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and the cytoplasmic tail. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC011447.1, ...
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3qxa: Conformational lability in the class II MHC 310 helix and adjacent extended strand dictate HLA-DM susceptibility and peptide exchange.
Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Oncology, Radiology and Clinical Immunology. (KITM) ...
RefSeq Summary (NM_002118): HLA-DMB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta (DMB) chain, both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP (class II-associated invariant chain peptide) molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ...
Helper T cells are stimulated to fight infections or diseases upon recognition of peptides from antigens that are processed and presented by the proteins of Major Histocompatibility Complex (MHC) Class II molecules. Degradation of a full protein into small peptide fragments is a lengthy process consisting of many steps and chaperones. Malfunctions during any step of antigen processing could lead to the development of self-reactive T cells or defective immune response to pathogens. Although much has been accomplished regarding how antigens are processed and presented to T cells, many questions still remain unanswered, preventing the design of therapeutics for direct intervention with antigen processing. Here, we review published work on the discovery and function of a MHC class II molecular chaperone, HLA-DO, in human, and its mouse analog H2-O, herein called DO. While DO was originally discovered decades ago, elucidating its function has proven challenging. DO was discovered in association with
Proteolysis of the class II-associated invariant chain generates a peptide binding site in intracellular HLA-DR molecules. Proc. Natl. Acad. Sci. USA. 1991. 88:
Hereditary major histocompatibility complex (MHC) class II deficiency (or bare lymphocyte syndrome) is a form of severe primary immunodeficiency with a total lack of MHC class II expression. It is due to a defect in the regulation of MHC class II genes. A novel gene was isolated by complementation c …
Cases reported • Severe Combined Immunodeficiency; Immunodeficiency, Severe Combined; Omenn Syndrome; Bare Lymphocyte Syndrome. On-line free medical diagnosis assistant. Ranked list of possible diseases from either several symptoms or a full patient history. A similarity measure between symptoms and diseases is provided.
TY - JOUR. T1 - IN-UTERO TRANSPLANTATION OF STEM CELLS IN BARE LYMPHOCYTE SYNDROME. AU - Touraine, J. L.. AU - Raudrant, D.. AU - Royo, C.. AU - Rebaud, A.. AU - Roncarolo, M. G.. AU - Souillet, G.. AU - Philippe, N.. AU - Touraine, F.. AU - Bétuel, H.. PY - 1989/6/17. Y1 - 1989/6/17. UR - http://www.scopus.com/inward/record.url?scp=0024400712&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=0024400712&partnerID=8YFLogxK. U2 - 10.1016/S0140-6736(89)92819-5. DO - 10.1016/S0140-6736(89)92819-5. M3 - Article. C2 - 2567387. AN - SCOPUS:0024400712. VL - 333. SP - 1382. JO - The Lancet. JF - The Lancet. SN - 0140-6736. IS - 8651. ER - ...
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Accurate prediction of antigen presentation by human leukocyte antigen (HLA) class II molecules would be valuable for vaccine development and cancer immunotherapies. Current computational methods trained on in vitro binding data are limited by insufficient training data and algorithmic constraints. Here we describe MARIA (major histocompatibility complex analysis with recurrent integrated architecture; https://maria.stanford.edu/ ), a multimodal recurrent neural network for predicting the likelihood of antigen presentation from a gene of interest in the context of specific HLA class II alleles. In addition to in vitro binding measurements, MARIA is trained on peptide HLA ligand sequences identified by mass spectrometry, expression levels of antigen genes and protease cleavage signatures. Because it leverages these diverse training data and our improved machine learning framework, MARIA (area under the curve = 0.89-0.92) outperformed existing methods
HLA Class II molecules are expressed by human thyroid epithelial cells (thyrocytes) in thyroid autoimmunity, although these cells are normally Class II-. gamma-Interferon (gamma-IFN) is probably involved in this expression, as suggested by its ability to induce Class II in cultured normal thyrocytes. We have now found that thyroid stimulating hormone (TSH) enhances Class II expression induced in cultured thyrocytes by gamma-IFN, and effects similar to those of TSH were obtained with dibutyryl cyclic AMP. A proportion of thyrocytes also expressed Class II following treatment with TSH or dibutyryl cyclic AMP in the absence of gamma-IFN, but the optimal activity of these mediators then appeared to be dependent upon the occurrence of some pre-existing Class II expression. These findings give insights into how a variety of mediators may influence Class II expression in thyroid autoimmunity.
Antigen presented to CD4+ T cells by major histocompatibility complex class II molecules (MHCII) plays a key role in adaptive immunity. Antigen presentation is initiated by the proteolytic cleavage of pathogenic or self proteins and loading of resultant peptides to MHCII. The loading and exchange of peptides to MHCII is catalyzed by a nonclassical MHCII molecule, HLA-DM (DM). It is well established that DM promotes peptide exchange in vitro and in vivo. However, the mechanism of DM-catalyzed peptide association and dissociation, and how this would affect epitope selection in human responses to infectious disease remain unclear. The work presented in this thesis was directed towards the understanding of mechanism of DM-mediated peptide exchange and its role in epitope selection. In Chapter II, I measured the binding affinity, intrinsic dissociation half-life and DM-mediated dissociation half-life for a large set of peptides derived from vaccinia virus and compared these properties to the peptide-specific
Clone REA296 recognizes MHC class II-associated invariant chain (Ii)-derived peptide (CLIP) complexes. MHC class II αβ heterodimers associate early during biosynthesis with a type II membrane protein, the invariant chain (Ii). The invariant chain serves as a chaperone for MHC II molecules and mediates trafficking to the endosomal pathway. In the endosomal pathway Ii is sequentially degraded, leaving a residual CLIP in the peptide-binding groove of MHC II. In presence of antigen peptide fragments, HLA-DM then binds to the MHC II molecule, releasing CLIP and allowing peptides to bind. REA296 detects HLA class II-positive cells which have impaired HLA-DM activity, and tumor cells that have escaped immuno-surveillance by CD4-positive T cells.Additional information: Clone REA296 displays negligible binding to Fc receptors. - Belgique
Mutations in human and/or mouse homologs are associated with this disease. Synonyms: bare lymphocyte syndrome type II; BLSII; SCID due to absent class II HLA antigens (disorder)
Over the last decade, our understanding and ability to predict the MHC class I pathway antigen presentation has improved substantially. This however does not hold for post-transnationally modified (PTM) antigens, where our understanding on how PTMs impact the potential for antigen presentation remains limited. Likewise, is our ability to predict MHC class II antigen presentation limited, and data suggest that properties other that MHC binding plays a critical role for the prediction of CD4 epitopes. Finally, is our understanding of the role of the T cell and the similarity of the presented peptide to the self proteome in the context of peptide immunogenicity very limited ...
The findings we have described here show a clear association between epithelial HLA-D/DR expression and autoimmunity. Furthermore, the ability of class II+ thyrocytes to present both exogenous antigens and autoantigens indicates an active role for these HLA-D/DR molecules in autoimmune pathogenesis. IFN-gamma is capable of inducing HLA-D/DR expression by thyroid epithelium, but a number of observations suggest the involvement of other inducers as well. Overall, we conclude that epithelial class II expression very probably plays a key role in the propagation and also in possibly the initiation of autoimmune attack. This is in accord with the proposal of a more general relationship between inappropriate or excessive class II expression and pathogenesis.
The structural basis of the interaction between the CD4 coreceptor and a class II major histocompatibility complex (MHC) is described. The crystal structure of a complex containing the human CD4 N-terminal two-domain fragment and the murine I-A(k) class II MHC molecule with associated peptide (pMHCII) shows that only the top corner of the CD4 molecule directly contacts pMHCII. The CD4 Phe-43 side chain extends into a hydrophobic concavity formed by MHC residues from both alpha2 and beta2 domains. A ternary model of the CD4-pMHCII-T-cell receptor (TCR) reveals that the complex appears V-shaped with the membrane-proximal pMHCII at the apex. This configuration excludes a direct TCR-CD4 interaction and suggests how TCR and CD4 signaling is coordinated around the antigenic pMHCII complex. Human CD4 binds to HIV gp120 in a manner strikingly similar to the way in which CD4 interacts with pMHCII. Additional contacts between gp120 and CD4 give the CD4-gp120 complex a greater affinity. Thus, ligation of ...
Vaccination of colon cancer patients with X-irradiated autologous tumor cells and Bacillus Calmette-Guérin results in a significant reduction in tumor recurrence. A study was undertaken to determine whether the expression of tumor-associated antigens, expression of major histocompatibility complex molecules, or the cellular composition of the vaccine cells correlates with vaccine efficacy. A significant increase in the percentage of histocompatibility leukocyte antigen (HLA) class II molecule-expressing tumor cells was the only marker with a positive correlation. Because HLA class II molecule expression is not a prognostic marker in control patients, it was hypothesized that HLA class II molecules are involved in the induction of tumor immunity in patients treated with the autologous colon tumor vaccine. Enhancement of HLA class II molecule-expressing cells could be induced in X-irradiated colon tumor cells injected into the skin of mice when the cells were mixed with γ-interferon. Therefore, ...
Recent gene expression studies have suggested that down-regulation of HLA class II expression has a major biological effect reflected in clinical tumor characteristics and outcome. This has been shown for B-cell lymphomas, that naturally express HLA class II on lymphoma cells (8, 22), but also for carcinomas in which HLA class II can be expressed on the antigen-presenting cells within the tumor (24). It is increasingly appreciated that not only HLA class I but also class II is essential for mounting an adequate antitumor immune response. Antigen presentation via HLA class II is indispensable to activate a CD4+ T-cell population that may induce a CD8+ T cell-mediated cytotoxic antitumor response (25, 26) and recruit additional effector cell populations, such as macrophages (26, 27). In carcinomas, an immune-mediated antitumor response is mainly mediated by professional antigen-presenting cells.. In B-cell lymphomas, both professional antigen-presenting cells as well as the tumor B cells may play ...
Enhancer factor C, EFC, EF-C, MHC class II regulatory factor RFX, MHC class II regulatory factor RFX1, regulatory factor X, 1 (influences HLA class II expression), Regulatory factor X 1, RFX, trans-acting regulatory factor 1, Transcription factor ...
HLA-DO/H2-O is a highly conserved, nonpolymorphic MHC class II-like molecule expressed in association with H2-M in thymic epithelial cells, B lymphocytes, and primary dendritic cells. The physiological function of DO remains unknown. The finding of cell maturation-dependent DO expression in B lymphocytes and dendritic cells suggests the possibility that H2-O functions to promote the presentation of exogenous Ag by attenuating presentation of endogenous self-peptides. In the current study, we report that H2-O−/− mice spontaneously develop high titers of IgG2a/c antinuclear Abs (ANAs) with specificity for dsDNA, ssDNA, and histones. Reconstitution of RAG1−/− mice with T and B cells from H2-O−/− or wild-type mice demonstrated that production of ANAs requires participation of CD4+ T cells from H2-O−/− mice. Bone marrow chimeras demonstrated that loss of H2-O expression in thymic epithelial cells did not induce ANAs, and that lack of H2-O expression in bone marrow-derived cells was ...
Herman, would you find the following *substitution* sufficient? It reads somewhat more naturally than the insertion of your sentence just before the table, which smacks of repetition. -Pat , ,-------- ,, , ,3.3 RDFS Interpretations ,, , .... , , ,,Although not strictly necessary, it is convenient to state the RDFS ,,semantics in terms of a new semantic construct, a class, i.e. a ,,resource which represents a set of things in the universe which all ,,have that class as the value of their rdf:type property. Classes are ,,defined to be things of type rdfs:Class, and the set of all classes ,,in an interpretation will be called IC. The semantic conditions are ,,stated in terms of a mapping ICEXT (for the Class Extension in I) , ,from from *IC to the set of subsets of IR*. The meanings of ICEXT ,and IC in a , ,rdf-interpretation of the RDFS vocabulary are completely defined by ,,the first two conditions in the table below. Notice that a class may ,,have an empty class extension; that (as noted ...
These kits utilize a patented technique for exchanging up to ten peptides on an MHC class I tetramer. Components for quantifying the extent of peptide exchange by flow cytometry are included ...
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Example: Human leukocyte antigen (HLA) alleles[edit]. HLA constitutes a group of cell surface antigens also known as the MHC of ... Table 2. Linkage disequilibrium among HLA alleles in pan-Europeans[15] HLA-A alleles i HLA-B alleles j Δ. i. j. {\displaystyle ... Antigen i +. {\displaystyle +}. A. 1. +. {\displaystyle A1^{+}}. a. =. 376. {\displaystyle a=376}. b. =. 237. {\displaystyle b= ... HLA alleles B. 27. +. {\displaystyle B27^{+}}. a. =. 96. {\displaystyle a=96}. b. =. 77. {\displaystyle b=77}. C. {\ ...
"HLA Antigens in Kawasaki Disease". Pediatrics. 61 (2): 252-255. ISSN 0031-4005. Shigematsu, I; Shibata, S; Tamashiro, H; ...
Human leucocyte antigen polymorphisms[edit]. Main article: Human leukocyte antigen. Human leucocyte antigen (HLA) polymorphisms ... In West Africa an HLA class I antigen (HLA Bw53) and an HLA class II haplotype (DRB1*13OZ-DQB1*0501) are independently ... Gerbich antigen receptor negativity[edit]. Main article: Gerbich antigen system. The Gerbich antigen system is an integral ... Non-expression of Duffy antigen on red cells Miller, et al. 1976 P. vivax Non-expression of Duffy antigen on red cells Miller ...
"HLA in the Azores Archipelago: possible presence of Mongoloid genes". Tissue Antigens. Department of Internal Medicine, ... "Tissue Antigens. Department of Internal Medicine, Hospital de Santo Espirito de Angra do Heroismo, Azores. 54 (4): 349-59. doi: ... "Tissue Antigens. Department of Internal Medicine, Hospital de Santo Espirito de Angra do Heroismo, Azores. 54 (4): 349-59. doi: ... A24-B44-DR6-DQ1 HLA haplotypes of Oriental Mongoloid origin.[85] Presence of Mongoloids on the islands an unknown point in ...
CD74 (англ. HLA class II histocompatibility antigen gamma chain; HLA-DR antigens-associated invariant chain) - мембранный белок ... Riberdy J.M., Newcomb J.R., Surman M.J., Barbosa J.A., Cresswell P. HLA-DR molecules from an antigen-processing mutant cell ... Machamer C.E., Cresswell P. Biosynthesis and glycosylation of the invariant chain associated with HLA-DR antigens (англ.) // ... Ia-associated invariant chainMHC HLA-DR gamma chainCD74HLA class II histocompatibility antigen gamma chaingamma chain of class ...
2009). "Human embryonic stem cells hemangioblast express HLA-antigens". J Transl Med. 7 (1): 27. doi:10.1186/1479-5876-7-27. ...
"Human Leukocyte Antigen (HLA) System - Immunology; Allergic Disorders". Merck Manuals Professional Edition. Merck & Co. ... In humans MHC is also called human leukocyte antigen (HLA). Though cytotoxic-crossmatch assay can predict rejection mediated by ... Unlike virtually all other mammals, humans and other primates do not make αGal, and in fact recognize it as an antigen. During ... The T cells can recognize the donated organ's MHC antigens through one of two routes: a direct pathway, where the transplanted ...
Macrophages and T lymphocytes demonstrated a marked expression of HLA-DR antigen. A delayed type hypersensitivity reaction of ...
In humans MHC is also called human leukocyte antigen (HLA). Though cytotoxic-crossmatch assay can predict rejection mediated by ... Unlike virtually all other mammals, humans and other primates do not make αGal, and in fact recognize it as an antigen.[12] ... An animal's exposure to the antigens of a different member of the same or similar species is allostimulation, and the tissue is ... In the living donor, such presentation of self antigens helped maintain self tolerance.) Thereupon, the T cell receptors (TCRs ...
"Nixon, Douglas". Makgoba, M. W. (1983). Studies on the polymorphism of HLA class II antigens (Thesis). Thesis DPhil--University ... "Common West African HLA antigens are associated with protection from severe malaria". Nature. 352 (6336): 595-600. Bibcode: ... McMichael, A. J.; Ting, A.; Zweerink, H. J.; Askonas, Brigitte A. (1977). "HLA restriction of cell-mediated lysis of influenza ... Barouch, Dan H. (1995). Peptide binding and presentation by HLA-A2 (Thesis). Thesis DPhil--University of Oxford. "Immunology ...
Presence of the HLA-B27 antigen; (3) Onset of arthritis in a male over 6 years of age; (4) Acute (symptomatic) anterior uveitis ... The Anti-nuclear antigen (ANA) is positive in up to 80% of patients with oligoarthritis and is associated with a higher risk of ... HLA-B27, Rheumatoid factor and Anti-citrullinated protein antibody. These serological markers may be negative in children with ...
Thus, the ability to generate platelet products ex vivo and platelet products lacking HLA antigens in serum-free media would ... Generated platelets demonstrated an 85% reduction in class I HLA antigens. These platelets appeared to have normal function in ... "iPSC-Derived Platelets Depleted of HLA Class I Are Inert to Anti-HLA Class I and Natural Killer Cell Immunity". Stem cell ... DC-like antigen-presenting cells obtained from human induced pluripotent stem cells can serve as a source for vaccination ...
Low levels of human leukocyte antigen (HLA-DR) make MSC's hypoimmunogenic. MSC's have trilineage differentiation where they are ...
During tissue typing, an individual's human leukocyte antigens (HLA) are identified. HLA molecules are presented on the surface ... including HLA Class I A, B, and C genes, as well as HLA Class II DRB1, DRB3, DRB4, DRB5, DQA1, DQB1, DPA1, and DPB1 genes. HLA ... If HLA from the donor is recognized by the recipient's immune system as different from the recipient's own HLA, an immune ... More specifically, HLA mismatches between organ donors and recipients can lead to the development of anti-HLA donor-specific ...
It is most commonly caused by antibodies directed against donor leukocytes and HLA antigens. This is in contrast to transfusion ... in which the donor plasma has antibodies directed against the recipient HLA antigens, mediating the characteristic lung damage ...
... inferred by HLA study". Tissue Antigens. 57 (3): 192-199. doi:10.1034/j.1399-0039.2001.057003192.x. PMID 11285126.. ... Lin's research was based on the study of human tissue antigens (HLA) of Hoklo, Hakka and plains indigenous peoples. Through ...
Among immune-related refractoriness, antibodies against HLA antigens are the primary cause. Non-immune causes include ... testing for HLA antibodies). If an immune cause is suspected and HLA antibodies are detected, then HLA-selected platelet ... HLA and HPA-selected components should not be used if no HLA or HPA antibodies are detected. Colman, Robert W.; Marder, Victor ... platelet refractoriness Pathogen-reduced platelet component Alloantibodies to platelet antigens Human leucocyte antigen (HLA) ...
Krangel MS, Orr HT, Strominger JL (December 1979). "Assembly and maturation of HLA-A and HLA-B antigens in vivo". Cell. 18 (4 ... Wang Z, Cao Y, Albino AP, Zeff RA, Houghton A, Ferrone S (February 1993). "Lack of HLA class I antigen expression by melanoma ... Saper MA, Bjorkman PJ, Wiley DC (May 1991). "Refined structure of the human histocompatibility antigen HLA-A2 at 2.6 A ... The affinity of different H-2 and HLA antigens for beta-2-microglobulin". Journal of Immunology. 140 (7): 2322-9. PMID 2450918 ...
In West Africa an HLA class I antigen (HLA Bw53) and an HLA class II haplotype (DRB1*13OZ-DQB1*0501) are independently ... Human leucocyte antigen (HLA) polymorphisms common in West Africans but rare in other racial groups, are associated with ... Polymorphisms at the HLA loci, which encode proteins that participate in antigen presentation, influence the course of malaria ... There are four alleles of the gene which encodes the antigen, Ge-1 to Ge-4. Three types of Ge antigen negativity are known: Ge- ...
"Distribution of HLA antigens in Sadhu Chetty of Tamil Nadu, South India". Anthropologischer Anzeiger. 53: 221-230 - via JSTOR. ...
"Common West African HLA antigens are associated with protection from severe malaria". Nature. 352 (6336): 595-600. doi:10.1038/ ...
The usual route for sensitisation towards HLA antigens occurs in three instances; pregnancy, post blood transfusion and prior ... which bind to HLA and/or non-HLA molecules on the endothelium. Preformed donor-specific HLA antibodies resulting in hyperacute ... It became clear with time that it did not identify all preexisting donor-specific HLA antibodies (HLA-DSA). In recent years, ... HLA frequencies and racial differences need to be factored in but cannot be done. Moreover, significant false positive results ...
June 2018). "Defective HLA class I antigen processing machinery in cancer". Cancer Immunology, Immunotherapy. 67 (6): 999-1009 ... These tumor antigens are either TSA (Tumor-specific antigen) or TAA (Tumor-associated antigen). Tumor-specific antigens (TSA) ... Oncofetal antigens are tumor-associated antigens expressed by embryonic cells and by tumors. Examples of oncofetal antigens are ... Tumor cells have non-classical MHC class I on their surface, for example HLA-G. HLA-G is inducer of Treg, MDSC, polarise ...
"SCID due to absent class II HLA antigens (Concept Id: C0242583) - MedGen - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2017-07-28. ... MHC II proteins are also important for positive and negative selection in the thymus because they present antigens to immature ... MHC II proteins present exogenous antigens that activate CD4+ T-lymphocytes, immune cells that are responsible for activating ... "Orphanet: Immunodeficiency by defective expression of HLA class 2". www.orpha.net. Retrieved 2017-07-28. Bratzler, Dale W.; ...
Pöllänen P, Niemi M (1987). "Immunohistochemical identification of macrophages, lymphoid cells and HLA antigens in the human ... They are often found within tissues where they can be activated by antigen-presenting cells upon infection. They are present in ... Pöllänen P, Maddocks S (1988). "Macrophages, lymphocytes and MHC II antigen in the ram and the rat testis". Journal of ... Macrophages are directly involved in the fight against invading micro-organisms as well as being antigen-presenting cells which ...
Saper MA, Bjorkman PJ, Wiley DC (1991). "Refined structure of the human histocompatibility antigen HLA-A2 at 2.6 A resolution ... the HLA-A2 human histocompatibility antigen. This work was published in 1987, first at 3.5Å resolution (PDB entry 1HLA) and ... "Structure of the human class I histocompatibility antigen, HLA-A2". Nature. 329 (6139): 506-512. Bibcode:1987Natur.329..506B. ... "Pamela Bjorkman, PhD - ASHI 2017". 2017.ashi-hla.org. Archived from the original on 2017-11-07. Retrieved 2017-10-30. "AAI-BD ...
HLA) allo-antibodies (which are expressed by platelets) to fetuses whose platelets express the corresponding antigens. NAIT ... Platelet antigens are inherited from both mother and father. NAIT is caused by antibodies specific for platelet antigens ... "HLA-DRw52a is involved in alloimmunization against PL-A1 antigen". Human Immunology. 27 (2): 73-9. doi:10.1016/0198-8859(90) ... is strongly associated with both HLA-DRB3*0101 and HLA-DQB1*0201". Human Immunology. 34 (2): 107-14. doi:10.1016/0198-8859(92) ...
Multiple human leukocyte antigen (HLA) alleles are associated with NMOSD. NMO was associated in the past with many systemic ...
Human leukocyte antigen (HLA)-DR is positive in most patients. Occasional cases require in situ hybridization to identify the ... but immunophenotyping demonstrates myeloid antigens. In acute myeloblastic leukemia (M0), the blasts are agranular and ...
Macrophages and lymphocytes show marked expression of HLA-DR antigen. Arguably XO is the bone localization of the ...
Surface antigens[edit]. Terminally differentiated plasma cells express relatively few surface antigens, and do not express ... Another important surface antigen is CD319 (SLAMF7). This antigen is expressed at high levels on normal human plasma cells. It ... After leaving the bone marrow, the B cell acts as an antigen presenting cell (APC) and internalizes offending antigens, which ... cannot act as antigen-presenting cells because they no longer display MHC-II, and do not take up antigen because they no longer ...
... 和HLA-DR (人类T细胞的特异标志)。CTLA-4在活化T细胞表面的上调,对共激活受体有竞争性抑制作用,可以避免活化T细胞的过度活化。活化T细胞的表面糖基化情况也有改变[32]。 ... MR1 antigen presentation to mucosal-associated invariant T cells was highly conserved in evolution. Proceedings of the National ... An induced rebinding model of antigen discrimination. Trends Immunol. 2014, 35 (4): 153-8.
... for human leukocyte antigen (HLA) matching (see PGD for HLA matching) in order to donate to an ill sibling requiring HSCT. ... HLA-A, HLA-B, or HLA-C) increase the risk of graft rejection. A mismatch of an HLA Type II gene (i.e. HLA-DR, or HLA-DQB1) ... A compatible donor is found by doing additional HLA-testing from the blood of potential donors. The HLA genes fall in two ... the donor should preferably have the same human leukocyte antigens (HLA) as the recipient. About 25 to 30 percent of allogeneic ...
"Correlation between acetylcholine receptor antibody titer and HLA-B8 and HLA-DRw3 antigens in myasthenia gravis". Trans Am ... November 1979). "Primary biliary cirrhosis associated with HLA-DRw3". Tissue Antigens. 14 (5): 449-52. doi:10.1111/j.1399- ... Prior to refined typing for HLA-DQ and DR, the association with HLA-A1 and B8 was identified for coeliac disease in 1973 and ... HLA A1-B8-DR3-DQ2 haplotype (Also: AH8.1, COX,[1] Super B8, ancestral MHC 8.1[2] or 8.1 ancestral haplotype[3]) is a multigene ...
... human leukocyte antigens (HLA) - human papilloma virus (HPV) - human T cell lymphotropic virus type I (HTLV-I) - human T cell ... antigen - antigen presentation - antigen-presenting cell (APC) - antineoplastic - antiprotozoal - antiretroviral drugs - ... HLA - Hodgkin's disease - holistic medicine - homology (biology) - hormone - host - host factors - HPTN - HPV - HRSA - HTLV-I ...
These cells bind antigens presented on MHC I complex of virus-infected or tumour cells and kill them. Nearly all nucleated ... Basophils are chiefly responsible for allergic and antigen response by releasing the chemical histamine causing the dilation of ... Dendritic cells (Although these will often migrate to local lymph nodes upon ingesting antigens) ... class II molecules on antigen-presenting cells. Helper T cells make cytokines and perform other functions that help coordinate ...
This is carried out by using donor-derived antigen-presenting cells. These new methods have reduced culture time to 10-12 days ... HLA-DR, CD25, CD80 (B cells). Tests for T cell function: skin tests for delayed-type hypersensitivity, cell responses to ... recurrent infections and failure of the development of antibodies on exposure to antigens. The 1999 criteria also distinguish ... selective immunoglobulin A deficiency Specific antibody deficiency to specific antigens with normal B cell and normal Ig ...
... that use recombinant antigens will not have a false-positive result. ... Genetic markers: HLA-B8, HLA-DR2, HLA-DR3. *Race: Blacks, Hispanics, Asians, and Native Americans ...
... or using human leukocyte antigen antigens. The current techniques for paternity testing are using polymerase chain reaction ( ... In the 1960s, highly accurate genetic paternity testing became a possibility when HLA typing was developed, which compares the ... genetic fingerprints on white blood cells between the child and alleged parent.[10] HLA tests could be done with 80% accuracy, ...
TI-1 antigen[edit]. TI-1 antigens have an intrinsic B cell activating activity, that can directly cause proliferation and ... TI-2 antigen[edit]. Second group of TI antigens consists mainly of highly repetitive surface structures (epitopes) of ... TI-1 antigen, which has an activity that can directly activate B cells and TI-2 antigen, which has highly repetitive structure ... TI-1 antigens activate B-cells via Toll like receptors, which are, in human, expressed on the surface of B lymphocytes after ...
Antigens can be classified according to their source. Exogenous antigens[edit]. Exogenous antigens are antigens that have ... T-independent antigen - Antigens that stimulate B cells directly.. *Immunodominant antigens - Antigens that dominate (over all ... Tumor antigens[edit]. Tumor antigens are those antigens that are presented by MHC class I or MHC class II molecules on the ... A native antigen is an antigen that is not yet processed by an APC to smaller parts. T cells cannot bind native antigens, but ...
Memorijske T ćelije su podskup antigen - specifičnih T ćelijs koje traju dugoročno nakon savladavanja infekcije.[1] One se brzo ... Somatska hipermutacija • V(D)J rekombinacija • Sastavna raznovrsnost • Promena imunoglobulinske klase • MHC/HLA ... Ove ćelije prepoznaju svoje ciljeve putem vezanja za antigen koji je asociran sa molekulama MHC klase I, koje se ispoljavaju na ... MR1 antigen presentation to mucosal-associated invariant T cells was highly conserved in evolution. 2009 ...
Binding of antigens to IgE already bound by the FcεRI on mast cells causes cross-linking of the bound IgE and the aggregation ... FcεRI is expressed on mast cells, basophils, and the antigen-presenting dendritic cells in both mice and humans. ... IgE also plays a pivotal role in responses to allergens, such as: anaphylactic drugs, bee stings, and antigen preparations used ... Degranulation processes 1 - antigen; 2 - IgE antibody; 3 - FcεRI receptor; 4 - preformed mediators (histamine, proteases, ...
HLA-DR3 and HLA-DRw52 human leukocyte antigen (HLA) markers; collectively known as Jo-1 syndrome.[25][35] ... Extractable nuclear antigens[edit]. Extractable nuclear antigens (ENA) are a group of autoantigens that were originally ... Each well of a microtitre plate is coated with either a single antigen or multiple antigens to detect specific antibodies or to ... Target antigen. Sensitivity (%) SLE. Drug-induced LE. Diffuse systemic sclerosis. Limited systemic scleroderma. Sjögren ...
Exogenous antigens for IgA have not been identified in the kidney, but it is possible that this antigen has been cleared before ... Some HLA alleles have been suspected along with complement phenotypes as being genetic factors. Non-aggressive Berger's disease ... Associations described include those with C4 null allele, factor B Bf alleles, MHC antigens and IgA isotypes. ACE gene ... It has also been proposed that IgA itself may be the antigen. ... abnormal mucosal antigen handling) and not the ultimate cause ...
HLA antigen.jpg 1.361 × 876; 124 KB. *. HLA region.jpg 1.104 × 653; 52 KB. ...
... may be caused by a bacterial antigen; the occurrence of this syndrome is strongly linked to HLA-B27 genotype, but the ...
In these cases, patients should be tested for the presence of HLA-DQ2/DQ8 genetic markers because a negative HLA-DQ2 and HLA- ... There is evidence that not only gliadin (main cytotoxic antigen of gluten), but also other proteins present in gluten and ... A 2015 systematic review showed that 20% of NCGS patients who presented with negative serology, HLA-DQ2 and/or HLA-DQ8 ... especially in patients positive for HLA DQ2 and/or DQ8 haplotypes, is celiac disease, with a documented prevalences ranging ...
... they are professional antigen-presenting cells, they regulate other immune cell functions (e.g., CD4+ T cell, dendritic cell, B ...
The HLA class II locus makes patients susceptible to the condition. Most SPS patients have the DQB1* 0201 allele.[2] This ... The antibodies appear to interact with antigens in the brain neurons and the spinal cord synapses, causing a functional ...
... any antibody produced against this antigen (which mimics the self-antigens) can also, in theory, bind to the host antigens, and ... Klein J, Sato A (September 2000). "The HLA system. Second of two parts". N. Engl. J. Med. 343 (11): 782-6. doi:10.1056/ ... Molecular Mimicry - An exogenous antigen may share structural similarities with certain host antigens; thus, ... T-Cell-B-Cell discordance - A normal immune response is assumed to involve B and T cell responses to the same antigen, even if ...
"Colonia Tovar: the history of a semi-isolated Venezuelan population of German ancestry described by HLA Class I genes". Tissue ... Antigens. 62 (5): 401-407. ISSN 0001-2815.. .mw-parser-output cite.citation{font-style:inherit}.mw-parser-output .citation q{ ...
Antigens presented on MHC 1 molecules activates CD8+ T cells on keratinocytes or by encounters with activated CD4+ helper T ... It is associated with HLA-DQB1.[16][36] ... Autoimmune response to epithelial self-antigens remains a ... An immune-mediated mechanism where basal keratinocytes are being targeted as foreign antigens by activated T cells, especially ...
HLA-DQ is part of the MHC class II antigen-presenting receptor (also called the human leukocyte antigen) system and ... The two subunits of the HLA-DQ protein are encoded by the HLA-DQA1 and HLA-DQB1 genes, located on the short arm of the sixth ... Almost all people (95%) with coeliac disease have either the variant HLA-DQ2 allele or (less commonly) the HLA-DQ8 allele.[28][ ... Furthermore, around 5% of those people who do develop coeliac disease do not have typical HLA-DQ2 or HLA-DQ8 alleles (see below ...
... mobilized human leukocyte antigen (HLA)-mismatched allogeneic peripheral blood stem cells following a reduced-intensity ... Matched HLA between donor and recipient is not necessary. The stem cells are collected from donor's blood through a process ... Donor's Requirements: Mismatched HLA with recipient Age between 18 and 60 years old Good overall state of health No major heart ... To overcome the intolerable severe reactions of high-dose chemotherapy and GVHD, as well as the challenge to find HLA-matched ...
B51 is a split antigen of the broad antigen B5, and is a sister serotype of B52.[2] There are a large number of alleles within ... derived from IMGT/HLA *^ a b c d e f g h i j k l m n o p q r s t u v w x y z aa ab ac ad ae af ag ah ai aj ak al am an ao ap aq ... EBI-HLA B*5101 1e28​, 1e27​ HLA-B51 (B51) is an HLA-B serotype. The serotype identifies the more common HLA-B*51 gene products. ... the association of HLA antigens". J. Med. Virol. 7 (4): 287-97. doi:10.1002/jmv.1890070405. PMID 6950026.. ...
HLA-B12, HLA-B51, HLA-Cw7, HLA-A2, HLA-A11, and HLA-DR2 are examples of human leukocyte antigen types associated with aphthous ... or present a more substantial barrier to microbes and antigens, but this is unclear. Nicotine is also known to stimulate ... stomatitis.[2][5] However, these HLA types are inconsistently associated with the condition, and also vary according to ...
... is part of a family of genes called the human leukocyte antigen (HLA) complex. The HLA complex helps the immune system ... HLA-B*45ZJ, HLA-B-3506, HLA-B-3905, HLA-B-5502, HLA-B-5602, HLA-B15, HLA-B39, HLA-B49, HLA-B50, HLA-B55, HLA-B59, HLA-B61, HLA- ... They are HLA-A, HLA-B, (both Class I MHCs) and HLA-DR (a Class II MHC).[5] If the two tissues have the same genes coding for ... In humans, the HLA-B gene and two related genes, HLA-A and HLA-C, are the major genes in MHC class I. ...
HLA)). This MHC: antigen complex is recognized by T-cells passing through the lymph node. Exogenous antigens are usually ... Exogenous antigensEdit. Antigen presentation stimulates T cells to become either "cytotoxic" CD8+ cells or "helper" CD4+ cells. ... Antigen presentationEdit. Main article: Antigen presentation. Acquired immunity relies on the capacity of immune cells to ... Endogenous antigensEdit. Endogenous antigens are produced by intracellular bacteria and viruses replicating within a host cell ...
HLA) The human leukocyte antigen (HLA) is not a single antigen, but is rather a group of proteins that are located on the ... Human leukocyte antigen (HLA). The human leukocyte antigen (HLA) is not a single antigen, but is rather a group of proteins ... Research on human blood cells in the 1950s identified three genes associated with the HLA (HLA-A, HLA-B, HLA-C). In the 1970s, ... Antigen World of Forensic Science COPYRIGHT 2005 Thomson Gale. Antigen. Antigens, which are usually proteins or polysaccharides ...
AntigensHLA AntigensHLA-A AntigensHLA-A1 AntigenHLA-A11 AntigenHLA-A2 AntigenHLA-A24 AntigenHLA-A3 AntigenHLA-B AntigensHLA-B13 ... AntigensHLA AntigensHLA-A AntigensHLA-A1 AntigenHLA-A11 AntigenHLA-A2 AntigenHLA-A24 AntigenHLA-A3 AntigenHLA-B AntigensHLA-B13 ... AntigenHLA-B39 AntigenHLA-B40 AntigenHLA-B44 AntigenHLA-B51 AntigenHLA-B52 AntigenHLA-B7 AntigenHLA-B8 AntigenHLA-C AntigensHLA ... AntigenHLA-B39 AntigenHLA-B40 AntigenHLA-B44 AntigenHLA-B51 AntigenHLA-B52 AntigenHLA-B7 AntigenHLA-B8 AntigenHLA-C AntigensHLA ...
The protein is called human leukocyte antigen B27 (HLA-B27). ... HLA-B27 is a blood test to look for a protein that is found on ... Human leukocyte antigen B27; Ankylosing spondylitis-HLA; Psoriatic arthritis-HLA; Reactive arthritis-HLA ... The protein is called human leukocyte antigen B27 (HLA-B27).. Human leukocyte antigens (HLAs) are proteins that help the bodys ... Human Leukocyte Antigen (HLA) B-27 - blood. In: Chernecky CC, Berger BJ, eds. Laboratory Tests and Diagnostic Procedures. 6th ...
... antigen-presenting molecules, and other proteins involved in immune function. The human leukoc ... The earliest HLA associations with rheumatic diseases, such as the association of the HLA-B*27 allele at the HLA-B gene with ... antigen-presenting molecules, and other proteins involved in immune function. The human leukocyte antigen (HLA) complex is ... including the human leukocyte antigen (HLA) genes (figure 1). Thus, the human MHC region is also referred to as the HLA region ...
Typing for HL-A antigens had shown a positive correlation between HL-A 8 and myasthenia gravis which was significantly higher ... HL-A 2-positive patients more often had thymomas and antibodies to skeletal muscle than HL-A 2-negative patients; HL-A 2- ... The fact that the clinical aspects of the HL-A 8-negative and HL-A 2-positive patients were different from those of the HL-A 8- ... Myasthenia Gravis, Autoantibodies, and HL-A Antigens Br Med J 1974; 1 :131 ...
A process called HLA typing makes sure that the donor and recipient are closely matched. ... Why HLA testing is done. HLA testing is done to identify your pattern of antigens and to find antibodies to the HLA antigens. ... Human leukocyte antigen (HLA) testing. Human leukocyte antigen (HLA) testing is also called HLA typing or tissue typing. It is ... How HLA testing is done. A sample of blood is taken by inserting a needle into a vein in your arm. Sometimes a swab of cells is ...
A process called HLA typing makes sure that the donor and recipient are closely matched. ... Why HLA testing is done. HLA testing is done to identify your pattern of antigens and to find antibodies to the HLA antigens. ... Human leukocyte antigen (HLA) testing. Human leukocyte antigen (HLA) testing is also called HLA typing or tissue typing. It is ... Cancer information / Diagnosis and treatment / Tests and procedures / Human Leukocyte Antigen (HLA) testing ...
... neural network for predicting the likelihood of antigen presentation from a gene of interest in the context of specific HLA ... In addition to in vitro binding measurements, MARIA is trained on peptide HLA ligand sequences identified by mass spectrometry ... A neural network trained on diverse datasets improves prediction of HLA class II epitope presentation. ... expression levels of antigen genes and protease cleavage signatures. Because it leverages these diverse training data and our ...
A test indicating that HLA-B27 is present means that the patient might have a risk of... ... HLA-B27 is a human leukocyte antigen that helps the body differentiate its own cells from foreign substances. ... Patients may get an HLA-B27 antigen test to find the cause of joint swelling and pain. Another reason for an HLA test is to see ... HLA-B27 is a human leukocyte antigen that helps the body differentiate its own cells from foreign substances. A test indicating ...
Human leukocyte antigen (HLA) typing. What is this test?. This test looks at the human leukocyte antigens (HLA) in your blood. ... Testing helps make sure you have the best possible match between your HLA antigens and those on the organ you receive. You may ... The results will show the degree to which HLA antigens match between you and the donor. ... HLA Antigen. Does this test have other names?. ... antibodies that will react with HLA antigens on a new ...
HLA class II regulation and structure: Analysis with HLA-DR3 and HLA-DP point mutants. J Exp Med 1985; 162: 1193-1207.CrossRef ... Antigen presentation and assembly by mouse I-Ak class II molecules in human APC containing deleted or mutated HLA DM molecules ... Accumulation of HLA-DM, a regulator of antigen presentation, in MHC class II compartments. Science 1994; 266: 1566-1569. ... Invariant chain peptides in most HLA-DR molecules of an antigen-processing mutant. Science 1992; 258: 1801-1804.CrossRefGoogle ...
Recent evidence suggests that reduced expression of target protein antigens and human leukocyte antigen (HLA) molecules is the ... Recent evidence suggests that reduced expression of target protein antigens and human leukocyte antigen (HLA) molecules is the ... HLA class II antigen presentation by prostate cancer cells Prostate Cancer Prostatic Dis. 2008;11(4):334-41. doi: 10.1038/sj. ... The purpose of this study was to investigate the prospect of antigen specific immunotherapy against prostate cancer via the HLA ...
Structure of the human class I histocompatibility antigen, HLA-A2.. Bjorkman PJ1, Saper MA, Samraoui B, Bennett WS, Strominger ... An unknown antigen is found in this site in crystals of purified HLA-A2. ... The class I histocompatibility antigen from human cell membranes has two structural motifs: the membrane-proximal end of the ... A large groove between the alpha-helices provides a binding site for processed foreign antigens. ...
HLA B17, B37 and B62 were significantly increased in PsA patients. Univariate analyses suggest that the HLA antigens B37, B62 ... clinical manifestations were more reliable predictors of aggressive joint damage than were specific HLA antigens. However, HLA ... Disease manifestations and HLA antigens in psoriatic arthritis in northern Sweden. Alenius, Gerd-Marie Umeå universitet, ... HLA antigens, Joint damage, Psoriatic arthritis Nationell ämneskategori Reumatologi och inflammation Identifikatorer. URN: urn: ...
tr,Q30003,Q30003_HUMAN Lymphocyte antigen (Fragment) OS=Homo sapiens OX=9606 GN=HLA-DQB1 PE=4 SV=1 ... Lymphocyte antigenImported. ,p>Information which has been imported from another database using automatic procedures.,/p> ,p>,a ...
HLA class I typing, low resolution one. Antigen equivalent. Service Code: 81374, Service Type: Medical ...
Antigens, HLA-DS. A group of the D-related HLA Antigens found to differ from the DR Antigens in Genetic Locus and therefore ... These Antigens are polymorphic Glycoproteins comprising alpha and beta chains and are found on lymphoid and other Cells, often ...
HLA) in your blood. It helps match donors and recipients for stem-cell and organ transplants. ... This test looks at the human leukocyte antigens ( ... HLA Antigen. Does this test have other names?. Human leukocyte ... antigen (HLA) typing. What is this test?. This test looks at the human leukocyte antigens (HLA) in your blood. This test is ... Testing helps make sure you have the best possible match between your HLA antigens and those on the organ you receive. You may ...
Antigen, HLA-A1. A specific HLA-A Surface Antigen subtype. Members of this subtype contain alpha chains that are encoded by the ...
Genetic modulation of antigen presentation by HLA-B27 molecules.. L Pazmany, S Rowland-Jones, S Huet, A Hill, J Sutton, R ... Genetic modulation of antigen presentation by HLA-B27 molecules.. L Pazmany, S Rowland-Jones, S Huet, A Hill, J Sutton, R ... These data are compatible with the presence of a factor(s), possibly HLA linked, interfering with antigen presentation by ... None of the eight B cell lines that expressed HLA-B27 presented a known peptide epitope to CTL. However, cells from a family ...
HLA-DR antigens in small and large intestinal epithelia were examined in Crohns disease (CD). Seventy-two biopsy specimens (10 ... Crohns disease elemental diet HLA-DR antigens large intestine small intestine This work was partly supported by a grant from ... Wang CY, Al-Katib A, Lane CL, et al: Induction of HLA-DC/ DS (Leu 10) antigen expression by human precursor B cell lines. J Exp ... HLA-DR antigens in small and large intestinal epithelia were examined in Crohns disease (CD). Seventy-two biopsy specimens (10 ...
HLA Class I Histocompatibility Antigen, B-27 alpha Chain*HLA Class I Histocompatibility Antigen, B-27 alpha Chain ... "HLA-B27 Antigen" by people in Harvard Catalyst Profiles by year, and whether "HLA-B27 Antigen" was a major or minor topic of ... A specific HLA-B surface antigen subtype. Members of this subtype contain alpha chains that are encoded by the HLA-B*27 allele ... "HLA-B27 Antigen" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical Subject ...
"HLA-DR2 Antigen" by people in Harvard Catalyst Profiles by year, and whether "HLA-DR2 Antigen" was a major or minor topic of ... A broad specificity HLA-DR antigen that is associated with HLA-DRB1 CHAINS encoded by DRB1*01:15 and DRB1*01:16 alleles. ... "HLA-DR2 Antigen" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical Subject ... HLA-DM captures partially empty HLA-DR molecules for catalyzed removal of peptide. Nat Immunol. 2011 Jan; 12(1):54-61. ...
tr,F4YZW3,F4YZW3_HUMAN MHC class II antigen (Fragment) OS=Homo sapiens OX=9606 GN=HLA-DRB1 PE=4 SV=1 ... Name:HLA-DRB1Imported. ,p>Information which has been imported from another database using automatic procedures.,/p> ,p>,a href ... MHC class II antigenImported. ,p>Information which has been imported from another database using automatic procedures.,/p> ,p>, ...
Here, we review published work on the discovery and function of a MHC class II molecular chaperone, HLA-DO, in human, and its ... Here, we review published work on the discovery and function of a MHC class II molecular chaperone, HLA-DO, in human, and its ... Malfunctions during any step of antigen processing could lead to the development of self-reactive T cells or defective immune ... DO was discovered in association with another chaperone HLA-DM (DM) but unlike DM, its distribution is more tissue specific, ...
Epitope analysis of HLA-DQ antigens: what does the antibody see?. [Anat R Tambur, Jimmy Rosati, Shirley Roitberg, Denis Glotz, ... Human leukocyte antigen (HLA)-DQ has emerged as the alloantibody most frequently associated with the generation of de novo ... Our data support the need for changing the manner in which HLA-DQ antigens and antibodies are evaluated for organ ... The generation of HLA-DQ de novo DSA was interrogated in 40 transplant recipients who were immunologically naive before their ...
Hla-a antigens explanation free. What is Hla-a antigens? Meaning of Hla-a antigens medical term. What does Hla-a antigens mean? ... Looking for online definition of Hla-a antigens in the Medical Dictionary? ... redirected from Hla-a antigens). Also found in: Dictionary, Encyclopedia. human leukocyte antigen (HLA). any one of four ... human leukocyte antigen (HLA). The human MAJOR HISTOCOMPATIBILITY COMPLEX.. human leukocyte antigen. ; HLA antigenic molecules ...
MHC class II molecule interacts with HLA_DM, and HLA_DO in B-cells, in order to release CLIP and facilitate the binding of ... In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) ... Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the ... also to express HLA-DO. Lysosomal microenvironment has been implicated in the regulation of antigen loading into MHC II ...
... are presented on the cell surface in the context of HLA-A*02:01 (HLA-A2) molecules (13, 14). HLA-A2 is the most common HLA-I ... Pr20 binds to ALY/HLA-A2 complexes in PRAME/HLA-A2-expressing leukemias. TCRm clones reactive with ALY/HLA-A2 complexes were ... HLA-A2- AML cell line HL60, indicating that the epitope was restricted by HLA-A2. In addition, Pr20 did not bind PRAME-HLA-A2+ ... We aimed to identify a TCRm Ab that recognized ALY/HLA-A2, but not HLA-A2 alone or in complex with irrelevant HLA-A2-binding ...
A therapeutic T cell receptor mimic antibody targets tumor-associated PRAME peptide/HLA-I antigens. ... A therapeutic T cell receptor mimic antibody targets tumor-associated PRAME peptide/HLA-I antigens. ... Preferentially expressed antigen in melanoma (PRAME) is a cancer-testis antigen that is expressed in many cancers and leukemias ... is presented in the context of human leukocyte antigen HLA-A*02:01 molecules for recognition by the T cell receptor (TCR) of ...
  • http://hla.alleles.org/nomenclature/ (Accessed on November 29, 2017). (uptodate.com)
  • https://maria.stanford.edu/ ), a multimodal recurrent neural network for predicting the likelihood of antigen presentation from a gene of interest in the context of specific HLA class II alleles. (nature.com)
  • Class I Human Histocompatibility (HLA) Surface Antigens encoded by more than 30 detectable Alleles on locus B of the HLA complex, the most polymorphic of all the HLA specificities. (online-medical-dictionary.org)
  • A disparity between antigen density and mean fluorescence intensity values for some alleles within an eplet group was noted, with mean fluorescence intensity values of the lowest fluorescence bead being one tenth of the highest fluorescence bead, despite the fact that the amount of antigen on these beads were not significantly different. (sigmaaldrich.com)
  • A broad specificity HLA-DR antigen that is associated with HLA-DRB1 CHAINS encoded by DRB1*01:15 and DRB1*01:16 alleles. (harvard.edu)
  • for example, there appear to be 300+ alleles in the HLA-B or DRB1 loci. (bio-medicine.org)
  • Several probes could be used to identify an array of HLA alleles. (bio-medicine.org)
  • By constructing an array of PCR primers complementary to the range of HLA polymorphisms, it is possible to detect the HLA alleles directly by PCR. (bio-medicine.org)
  • To date, two RA genetic susceptibility factors have been identified: HLA-DRB1-SE (Shared epitope) and PTPN22 620W alleles. (bioportfolio.com)
  • The predictive value of the alleles for diagnosis of RA was previously investigated in cohorts of caucasians patients with early unclassified arthritis that showed restrained association between RA and HLA-SE. (clinicaltrials.gov)
  • The association between the different HLA alleles among French West-Indian RA patients and the autoantibodies production. (clinicaltrials.gov)
  • There were no associations between HLA DRB1 alleles and clinical characteristics of CLL patients at diagnosis, including age, clinical stage according to Rai classification, surface CD38 expression, serum levels of lactate dehydrogenase (LDH) and β2-microglobulin ( data not shown ). (haematologica.org)
  • Neither of assessed HLA DRB1 alleles was associated with response to first-line treatment or mortality. (haematologica.org)
  • Clinical stage according to Rai classification as a unique parameter (Rai 0-1 vs 2-4), with HLA DRB1* 01, HLA DRB1*02 null alleles and CD38 surface expression was included for analysis. (haematologica.org)
  • Because of their invol- vement in generating immune responses, Human Leukocyte Antigen (HLA) alleles are considered can- didate genetic risk markers for periodontitis. (scirp.org)
  • Results: HLA-A*30 (P-value = 0.010), HLA- B*41 (P1 = 0.012 and P2 = 0.014), HLA-DRB1*13 (P1 = 0.031 and P2 = 0.063) alleles seemed to be associ- ated with protection against AP in Lebanese patients. (scirp.org)
  • Conclusion: In conclusion, protective, but no sus- ceptible HLA alleles were detected in AP. (scirp.org)
  • HLA -B*18 and HLA -Cw*07 alleles was found more frequently in Group1 than in Group 2 (14.3 percent vs 2.7 percent, p=0.026, and 31 percent vs 14.9 percent, p=0.036, respectively). (aaem.pl)
  • However, the frequencies of HLA -A*03 and HLA -Cw*03 alleles were increased in Group 2 compared to Group 1 (20.3 percent vs 7.1 percent, p=0.049 and 10.8 percent vs 0 percent, p=0.024, respectively). (aaem.pl)
  • Among HLA -class II genotypes, HLA -DQB1*03 allele was significantly increased in Group 2 (60.9 percent vs 38.1 percent, p=0.018), while a higher frequency of HLA -DR B1*03 and HLA -DR B1*14 alleles showed a tendency statistically significant in Group 1 (9.5 percent vs 1.4 percent, p=0.057 and 11.9 percent vs 2.7 percent, p=0.058, respectively). (aaem.pl)
  • HLA -B*18 and HLA -Cw*07 alleles may probably be associated with susceptibility to venom allergy, whereas HLA -A*03, HLA -Cw*03 and HLA -DQB1*03 seem to be protective markers in a small Turkish population. (aaem.pl)
  • The applicability of hTERT as a potential target for anticancer immunotherapy would be widened by the identification of epitopes restricted to other common HLA alleles, such as HLA-A3 antigen. (aacrjournals.org)
  • Our panel of highly representative HLA-DQ alleles will help to drive novel research to prevent transplant rejection and to contribute to more insight into DSA responses and we are thrilled to be working with Dr. Tambur, a world leader in this field. (californianewswire.com)
  • EH-57.1+ individuals therefore carry a 26 times higher risk of developing type I psoriasis than individuals who are EH-57.1-negative Further analysis of individual HLA alleles revealed that within EH-57.1, HLA class I antigens (Cw6-B57) were associated to a much higher extent with type I psoriasis than the HLA class II alleles (DRB1*0701-DQA1*0201-DQB1* 0303). (diva-portal.org)
  • No statistically significant differences were observed in the distribution of HLA‐G alleles between controls and RSA couples, however, 15% of the RSA women carried the HLA‐G*0106 allele compared to 2% of the control women. (deepdyve.com)
  • Furthermore, the HLA‐G alleles without the 14 bp sequence were prominent in the RSA males in contrast to the RSA women in whom alleles including the 14 bp sequence were frequently observed, especially as homozygotes. (deepdyve.com)
  • Another hypothesis concerned certain HLA‐G alleles associated with an altered expression profile of HLA‐G isoforms or reduced expression of certain HLA‐G isoforms. (deepdyve.com)
  • To identify possible epitopes presented by distinct HLA class II alleles, overlapping 18-mer peptides derived from NY-ESO-1 were synthetized and tested for recognition by CD4(+) T lymphocytes in autologous settings. (uzh.ch)
  • We identified three NY-ESO-1-derived peptides presented by DRB4*0101-0103 and recognized by CD4(+) T lymphocytes of two melanoma patients sharing these HLA class II alleles. (uzh.ch)
  • We have collected peripheral blood samples 26 patients receiving HCT and generated CTL restricted by HLA alleles commonly seen in Japanese population. (nii.ac.jp)
  • Journal Article] Identification of novel CTL epitopes of CMV-pp65 presented by a variety of HLA alleles. (nii.ac.jp)
  • in there you will find a Supplemental Table that includes a list of SNPs and alleles that can be used to predict the classical HLA alleles, as well as r2 values between SNP alleles and HLA alleles. (biostars.org)
  • Rather, class II molecules are on the surface of immune cells such as macrophages and B-lymphocytes that are designed to process cells and present the antigens from these cells to T lymphocytes. (encyclopedia.com)
  • The two classes of histocompatibility molecules allow an organism to in essence establish an inventory of what cells are "self" and to expose foreign antigens to the immune system so that antibodies to these antigens can be made. (encyclopedia.com)
  • The major histocompatibility complex (MHC) is a term used to describe a group of genes in animals and humans that encode a variety of cell surface markers, antigen-presenting molecules, and other proteins involved in immune function. (uptodate.com)
  • Accurate prediction of antigen presentation by human leukocyte antigen (HLA) class II molecules would be valuable for vaccine development and cancer immunotherapies. (nature.com)
  • An essential role for HLA-DM in antigen presentation by class II major histocompatibility molecules. (springer.com)
  • The extracellular domains of MHC class II molecules determine their processing requirements for antigen presentation. (springer.com)
  • HLA-DR molecules from an antigen-processing mutant cell line are associated with invariant chain peptides. (springer.com)
  • Invariant chain peptides in most HLA-DR molecules of an antigen-processing mutant. (springer.com)
  • Recent evidence suggests that reduced expression of target protein antigens and human leukocyte antigen (HLA) molecules is the predominant immune escape mechanism of malignant prostate tumor cells. (nih.gov)
  • Prostate tumor cells transduced with class II molecules efficiently presented tumor-associated antigens/peptides to CD4+ T cells. (nih.gov)
  • Genetic modulation of antigen presentation by HLA-B27 molecules. (rupress.org)
  • In studies of antigenic peptide presentation, we have found a healthy volunteer whose lymphoblastoid cells were unable to present three different virus-derived epitopes to cytotoxic T lymphocytes (CTL) despite expressing the correct restricting HLA-B27 molecules on the cell surface. (rupress.org)
  • The cloned cDNA was transfected into HLA-A- and B-negative HMy/C1R cells, and the B2702 molecules generated in this environment rendered these cells, after incubation with peptide, susceptible to lysis by peptide-specific CTL. (rupress.org)
  • These data are compatible with the presence of a factor(s), possibly HLA linked, interfering with antigen presentation by otherwise normal B2702 molecules in this family. (rupress.org)
  • HLA-DM captures partially empty HLA-DR molecules for catalyzed removal of peptide. (harvard.edu)
  • Helper T cells are stimulated to fight infections or diseases upon recognition of peptides from antigens that are processed and presented by the proteins of Major Histocompatibility Complex (MHC) Class II molecules. (frontiersin.org)
  • In general, polymorphic classical MHC class II molecules bind and present peptide antigens. (frontiersin.org)
  • After proteasomal processing, the PRAME300-309 peptide ALYVDSLFFL (ALY) is presented in the context of human leukocyte antigen HLA-A*02:01 molecules for recognition by the T cell receptor (TCR) of cytotoxic T cells. (jci.org)
  • Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. (rcsb.org)
  • To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. (rcsb.org)
  • HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. (rcsb.org)
  • In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. (rcsb.org)
  • Lysosomal microenvironment has been implicated in the regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and efficient peptide loading. (rcsb.org)
  • 3 MHC class II molecules bind to a CD74 homotrimer (also known as invariant chain or HLA class II histocompatibility antigen gamma chain). (rcsb.org)
  • The positions of mutations (blue) that alter interactions between class I molecules and the peptide-loading machinery are shown relative to the US2 binding site on HLA-A2 (magenta). (pnas.org)
  • Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). (prospecbio.com)
  • The crucial immunological function of the classical human major histocompatibility complex (MHC) class I molecules, human histocompatibility leukocyte antigen (HLA)-A, -B, and -C, is the presentation of peptides to T cells. (rupress.org)
  • The fetus, semiallograft by its genotype, escapes maternal allorecognition by downregulation of HLA-A and HLA-B molecules at this interface. (rupress.org)
  • We present three NK lines that are inhibited via the interaction of their NKAT3 receptor with HLA-G and with HLA-Bw4 molecules. (rupress.org)
  • Class I HLA molecules have diversified into two distinct, though structurally related, families of proteins. (diabetesjournals.org)
  • Unlike class Ia HLA molecules, class Ib HLA-E, -F, and -G antigens display very limited or no polymorphism within the human population, may function in presenting limited sets of peptides, and/or exhibit a restricted tissue expression ( 2 ). (diabetesjournals.org)
  • Thus, unlike polymorphic class Ia HLA molecules, which have evolved as efficient activators of immune responses, presentation of HLA-G may have specialized to increase the activation/effector thresholds of T-, NK, and antigen-presenting cells for the immune protection of the semiallogeneic fetus and certain autologous tissues. (diabetesjournals.org)
  • Antigen presentation to T cells is mediated by antigen-presenting cells (APCs) via two classes of HLA molecules: HLA Class I, recognized by CD8 + -expressing T cells (Class I is present on nearly all nucleated cells), and HLA Class II, recognized by CD4 + -expressing T cells. (diabetesjournals.org)
  • Peptides extracted from HLA-A2.1 class I major histocompatibility complex (MHC) molecules expressed on the antigen processing mutant CEMx721.174.T2 were characterized by electrospray ionization-tandem mass spectrometry. (sciencemag.org)
  • It binds to the leader peptide derived from the polymorphic classical major histocompatibility molecules HLA-A, HLA-B and HLA-C. This peptide binding is highly specific and stabilizes the HLA-E protein, allowing it to migrate to the cell surface. (portlandpress.com)
  • The anti-tumor effect of DLI after HLA-matched alloSCT is mediated by donor T cells recognizing minor histocompatibility antigens (MiHA) in the context of HLA molecules. (haematologica.org)
  • 12 Since these MiHA were all presented in HLA-A*02:01 and B*07:02, we selected 80 third-party EBV-B cell lines for co-expression of these HLA molecules, and genotyped all cell lines for more than one million SNPs. (haematologica.org)
  • This work requires availability of purified HLA-DQ and other HLA class II molecules, maintaining high physiologic accuracy of the three-dimensional structure. (californianewswire.com)
  • Since CD4(+) T lymphocytes play a critical role in generating antigen-specific cytotoxic T lymphocyte and antibody responses, we searched for NY-ESO-1 epitopes presented by histocompatibility leukocyte antigen (HLA) class II molecules. (uzh.ch)
  • HLA-E belongs to the MHC Class I molecules (MHC Class Ib, nonclassical) and it is expressed on. (biomol.com)
  • The published results revealed that the antibody cross-reacts with some classical MHC Class I molecules (MHC Class Ia): HLA-B7 (strongly), HLA-B8 (moderately), HLA-B27, -B44 (weakly). (biomol.com)
  • Here, we isolated exosomes from K562 cells (referred to as CoEX-A2s) engineered to express human leukocyte antigen (HLA)-A2 and costimulatory molecules such as CD80, CD83, and 41BBL. (ovid.com)
  • Fig. 4: MARIA trained on human HLA-DQ ligand peptides identified celiac-related gluten antigens. (nature.com)
  • Binds peptides derived from antigens that access the endocytic route of antigen presenting cells ( APC ) and presents them on the cell surface for recognition by the CD4 T-cells. (rcsb.org)
  • MHC class II molecule interacts with HLA_DM, and HLA_DO in B-cells, in order to release CLIP and facilitate the binding of antigenic peptides. (rcsb.org)
  • HLA-DRB1 takes an essential part in the immune system by presenting peptides derived from extracellular proteins. (prospecbio.com)
  • While the high polymorphism of these proteins ensures immune recognition of a variety of self-antigens and viral peptides, it also represents a major barrier to allo-transplantation. (diabetesjournals.org)
  • These CTL clones did not recognize any of the 10 peptides selected for specific association to HLA-A2.1 and derived from Melan-A/Mart-1, tyrosinase, gp100, or MAGE-3 proteins. (jimmunol.org)
  • Class I HLAs present peptides from inside the cell whereas class II HLAs present antigens from outside of the cell to T-lymphocytes. (antibodies-online.com)
  • A recent study shows that individuals with the allele HLA-B*46:01 have the fewest predicted binding peptides for SARS-CoV-2, suggesting they may be particularly vulnerable to COVID-19, as they were previously shown to be for SARS. (antibodies-online.com)
  • A different allele, HLA-B*15:03, showed the greatest capacity to present highly conserved SARS-CoV-2 peptides that are shared among common human coronaviruses, suggesting it could enable cross-protective T-cell based immunity. (antibodies-online.com)
  • Improved induction of melanoma-reactive CTL with peptides from the melanoma antigen gp100 modified at HLA-A*0201-binding residues. (jimmunol.org)
  • Upon stimulation with these peptides, melanoma-reactive CTL could be induced in vitro from PBL of some HLA-A2+ melanoma patients. (jimmunol.org)
  • Therefore, to enhance the immunogenicity of gp100 peptides, amino acid substitutions were introduced into G9154, G9209, and G9280 at HLA-A*0201-binding anchor positions, but not at TCR contact residues, to increase peptide class I MHC-binding affinity. (jimmunol.org)
  • Several modified gp100 peptides bound with greater affinity to HLA-A*0201 than unmodified peptides and were recognized by TIL specific for the natural epitopes. (jimmunol.org)
  • These peptides were used to sensitize PBL from HLA-A2+ melanoma patients in vitro using peptide-pulsed autologous PBMC as stimulators. (jimmunol.org)
  • Only seven dominant peptides were found, in contrast to over 200 associated with HLA-A2.1 on normal cells. (sciencemag.org)
  • These peptides were derived from the signal peptide domains of normal cellular proteins, were usually larger than nine residues, and were also associated with HLA-A2.1 in normal cells. (sciencemag.org)
  • A functioning TAP (transporter associated with antigen processing) molecule is required to transport these peptides into the endoplasmic reticulum, where they can interact with HLA-E. HLA-E then migrates to the cell surface, where it interacts with CD94/NKG2A receptors on natural killer cells. (portlandpress.com)
  • In this study, we extended our search for hTERT-derived immunogenic peptides to HLA-A3 antigen because this allele is expressed by 15-25% of patients and identify one such peptide that can trigger HLA-A3-restricted CTLs that kill hTERT + tumors from multiple histologies. (aacrjournals.org)
  • Human leukocyte antigen class I (HLA-I) presents antigenic peptides to cytotoxic CD8+ T cells (CTLs). (lu.se)
  • Antigen processing machinery (APM) proteins are involved in the maturation of HLA-I and in the selection of which peptides are - or are not - presented. (lu.se)
  • Additionally, in total 663 T-cell clones (containing at least 91 unique clones expressing different T-cell receptors) directed against HLA*02:01-restricted peptides of TAA WT1-RMF, RHAMM-ILS, Proteinase-3-VLQ, PRAME-VLD and NY-eso-1-SLL were isolated from HLA-A*02:01pos donors. (onmedica.com)
  • Further, the therapeutic efficacy of active immunization using antigenic HLA class I-restricted peptides may be improved by adding HLA class II-presented epitopes. (uzh.ch)
  • Interaction of HLA-DR with an acidic face of HLA-DM disrupts sequence-dependent interactions with peptides. (semanticscholar.org)
  • Using the information of the binding motif of HLA-B35, we selected and synthesized 61 different peptides (8mer to 10 mer) from TC cysteine protease. (nii.ac.jp)
  • HLA testing is done to identify your pattern of antigens and to find antibodies to the HLA antigens. (cancer.ca)
  • HLA antibodies. (rochester.edu)
  • People who have been pregnant or get a blood transfusion or organ transplant may have antibodies that will react with HLA antigens on a new transplant. (rochester.edu)
  • Our data support the need for changing the manner in which HLA-DQ antigens and antibodies are evaluated for organ transplantation. (sigmaaldrich.com)
  • HLA-DR antigens on the intestinal epithelia were identified by the indirect immunoperoxidase staining method using two mouse anti-HLA-DR monoclonal antibodies. (springer.com)
  • Ogasawara K, Kojima H, Ikeda H, et al: A study on class II antigens involved in the T cell proliferative responses to PPD using cross-reacting monoclonal antibodies in human and murine system. (springer.com)
  • The data provide rationale for developing TCRm antibodies as therapeutic agents for cancer, offer mechanistic insight on proteasomal regulation of tumor-associated peptide/HLA antigen complexes, and yield possible therapeutic solutions to target antigens with ultra-low surface presentation. (jci.org)
  • Transplantation induces new antibodies reactive to non-HLA antigens. (asnjournals.org)
  • Screening is hampered by the lack of true monospecific anti‐HLA‐B27 monoclonal antibodies. (currentprotocols.com)
  • HLA-DQ antibodies are likely also the most detrimental to graft survival. (californianewswire.com)
  • Human HLA specific antibodies crossreact with swine leucocyte antigens. (surrey.ac.uk)
  • Polyspecific HLA antibodies often crossreact with other HLA antigens through so called public and private determinants. (surrey.ac.uk)
  • Swine leucocyte antigens share approximately 75-87% homology with HLA and as such, it may be expected that some HLA antibodies would react with certain SLA antigens. (surrey.ac.uk)
  • Upon absorption of the HLA antibodies, the majority of anti-pig reactivity was abrogated. (surrey.ac.uk)
  • The eluates showed that HLA class I and II antibodies were eluted from pig splenocytes. (surrey.ac.uk)
  • We leveraged a collection of 14 ICI-resistant lung cancer samples to investigate whether alterations in genes encoding HLA Class I antigen processing and presentation machinery (APM) components or interferon signaling play a role in acquired resistance to PD-1 or PD-L1 antagonistic antibodies. (aacrjournals.org)
  • Research on human blood cells in the 1950s identified three genes associated with the HLA (HLA-A, HLA-B, HLA-C). In the 1970s, another gene was identified (HLA-D). With the advent of molecular technology beginning in the 1980s, more genes that code for proteins that function in the antigen complex have continued to be identified. (encyclopedia.com)
  • The major histocompatibility complex (MHC) in humans refers to a genetic region containing hundreds of genes, including the human leukocyte antigen (HLA) genes ( figure 1 ). (uptodate.com)
  • HLA genes express their gene products on the surface of white blood cells (hence the name 'human leukocyte antigen,' although HLA class I genes (see 'Class I region' below) are also expressed on all nucleated cells) and were originally recognized to contain the genes encoding 'tissue antigens' or 'tissue types. (uptodate.com)
  • Adapative immunity: Histocompatibility antigens and immune response genes. (uptodate.com)
  • In addition to in vitro binding measurements, MARIA is trained on peptide HLA ligand sequences identified by mass spectrometry, expression levels of antigen genes and protease cleavage signatures. (nature.com)
  • DNA test of HLA-related genes. (rochester.edu)
  • Genes in the MHC that may affect antigen processing. (springer.com)
  • Fling SP, Arp B, Pious D. HLA-DMA and -DMB genes are both required for MHC class II/peptide complex formation in antigen-presenting cells. (springer.com)
  • Defective processing and presentation of exogenous antigens in mutants with normal HLA class II genes. (springer.com)
  • n a collection of human genes on chromosome 6 that encode proteins that function in cells to transport antigens from within the cell to the cell surface. (thefreedictionary.com)
  • The Human Leukocyte Antigen (HLA) region, located on the short arm of chromosome 6 (6p21.3), is a highly polymorphic region containing about 200 genes. (bio-medicine.org)
  • The HLA region is the human equivalent of the Major Histocompatibility Complex (MHC), and as such contains a set of genes that serve as the backbone of antigen presentation. (bio-medicine.org)
  • The Class I proteins, classically involved in presenting endogenous antigens to CD8+ T-cells, are expressed by genes located in the HLA-A, -B and C loci. (bio-medicine.org)
  • Class I human histocompatibility (HLA) antigens encoded by a small cluster of structural genes at the C locus on chromosome 6. (curehunter.com)
  • The HLA-G gene has the same general structure as the classical MHC class I genes with five exons and three introns. (rupress.org)
  • In humans, MHC proteins are encoded by the Human Leukocyte Antigen (HLA), a group of more than 200 genes located closely together on the short arm of chromosome 6. (antibodies-online.com)
  • We investigated whether particular human leukocyte antigen (HLA) class I and class II genes contribute to the development of venom allergy. (aaem.pl)
  • Major histocompatibility complex (MHC) genes, also known as human leukocyte antigen (HLA) genes in humans, are the prominent susceptibility factor for many autoimmune diseases, including multiple sclerosis (MS), autoimmune diabetes (type 1 diabetes or T1D), and rheumatoid arthritis (RA). (sciencemag.org)
  • HLA-D is a so-called class II major histocompatibility molecule. (encyclopedia.com)
  • At the outer surface of the cell the molecule contains an antigen that has been acquired from the surrounding environment. (encyclopedia.com)
  • However, cells from a family member that expressed HLA-B8 could present an epitope peptide restricted by that molecule. (rupress.org)
  • The specific expression of HLA-G in placental trophoblast suggests an important role for this molecule in the immunological interaction between mother and child. (rupress.org)
  • Selective expression of the human class Ib HLA molecule HLA-G in immunologically protected sites and its function in the inhibition of NK and T-cell effector functions support an important role of this molecule in immunoregulation. (diabetesjournals.org)
  • We hypothesize that the expression of HLA-G as an immunomodulatory molecule may be relevant at sites of organ-specific autoimmunity, such as pancreatic islets. (diabetesjournals.org)
  • HLA-E (human leucocyte antigen-E) is a conserved class I major histocompatibility molecule which has only limited polymorphism. (portlandpress.com)
  • Understanding the unique structural and molecular properties that make the HLA-DQ molecule so pathogenic may eventually help us better predict which mismatches will induce harmful antibody formation, and which are more permissible. (californianewswire.com)
  • Using chronically infected HLA-B35-TG,we tried to identify the T cell epitopes that HLA molecule presents to the CD8 cytotoxic T cells. (nii.ac.jp)
  • The earliest HLA associations with rheumatic diseases, such as the association of the HLA-B*27 allele at the HLA-B gene with ankylosing spondylitis (AS) risk and the association of the HLA-DRB1*04 allele at the HLA-DRB1 gene with rheumatoid arthritis (RA), were discovered several decades ago. (uptodate.com)
  • Members of this subtype contain alpha chains that are encoded by the HLA-B*27 allele family. (harvard.edu)
  • We assessed HLA DRB1 allele frequency using low (two-digit) typing resolution. (haematologica.org)
  • In patients with HLA DRB1*01 allele, there was a trend towards a shorter time from diagnosis to treatment (log-rank test, p =0.07, Figure 1A . (haematologica.org)
  • Furthermore, HLA -A*01 allele frequency had a trend to be higher in Group 1 than in Group 2 (14.3 percent vs 4.1 percent, p=0.055). (aaem.pl)
  • Through its new ecommerce website, www.hlaprotein.com, Pure Protein now offers academic and commercial researchers the ability to purchase individual HLA reagents to detect, profile, and monitor allele-specific immune responses, as well as HLA peptide epitope binding services to aide in improving the design of vaccination and therapeutic targeting strategies. (californianewswire.com)
  • In type I, but not type II psoriasis, the Caucasian HLA extended haplotype (EH) Cw6-B57-DRB1*0701-DQA1*0201-DQB1*0303 named according to the B allele EH-57.1 was highly significantly overrepresented (p cor= 0.00021). (diva-portal.org)
  • The serotype identifies the B*38 allele products of the HLA-B gene-locus. (wikipedia.org)
  • Linkage studies indicate a factor in the HLA-class I region is more greatly associated, with HLA-B38 so far the only linked allele Marsh, S. G. (wikipedia.org)
  • For A11, the alpha "A" chain are encoded by the HLA-A*11 allele group and the β-chain are encoded by B2M locus. (wikipedia.org)
  • Allele Query Form IMGT/HLA - European Bioinformatics Institute Gregoriadis S, Zervas J, Varletzidis E, Toubis M, Pantazopoulos P, Fessas P (December 1982). (wikipedia.org)
  • The human leukocyte antigen (HLA) is not a single antigen, but is rather a group of proteins that are located on the surface of white blood cells. (encyclopedia.com)
  • Human leukocyte antigens (HLAs) are proteins that help the body's immune system tell the difference between its own cells and foreign, harmful substances. (medlineplus.gov)
  • Here, we show for the first time that prostate cancer cells express HLA class II proteins that are recognized by CD4+ T cells. (nih.gov)
  • As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. (rcsb.org)
  • In contrast, the Class II proteins, which associate with and present exogenous antigens to CD4+ T-cells, are expressed by the HLA DR, -DQ and DP loci. (bio-medicine.org)
  • High-throughput epitope discovery reveals frequent recognition of neo-antigens by CD4 + T cells in human melanoma. (nature.com)
  • Epitope analysis of HLA-DQ antigens: what does the antibody see? (sigmaaldrich.com)
  • None of the eight B cell lines that expressed HLA-B27 presented a known peptide epitope to CTL. (rupress.org)
  • Rapid antigen processing and presentation of a protective and immunodominant HLA-B*27-restricted hepatitis C virus-specific CD8+ T-cell epitope. (doaj.org)
  • To better define the immunological mechanisms underlying HLA-B*27-mediated protection in HCV infection, we analyzed the functional avidity, functional profile, antiviral efficacy and naïve precursor frequency of CD8+ T cells targeting the immunodominant HLA-B*27-restricted HCV-specific epitope as well as its antigen processing and presentation. (doaj.org)
  • The HLA-B*27-restricted CD8+ T-cell epitope was not superior to epitopes restricted by HLA-A*02 when considering the functional avidity, functional profile, antiviral efficacy or naïve precursor frequency. (doaj.org)
  • However, the peptide region containing the HLA-B*27-restricted epitope was degraded extremely fast by both the constitutive proteasome and the immunoproteasome. (doaj.org)
  • This efficient proteasomal processing that could be blocked by proteasome inhibitors was highly dependent on the hydrophobic regions flanking the epitope and led to rapid and abundant presentation of the epitope on the cell surface of antigen presenting cells. (doaj.org)
  • Our data suggest that rapid antigen processing may be a key immunological feature of this protective and immunodominant HLA-B*27-restricted HCV-specific epitope. (doaj.org)
  • Here, we report a high degree of epitope overlap and T cell promiscuity between susceptible HLA-DQ8 and HLA-DQ8 transdimer. (sciencemag.org)
  • Using a method of epitope deduction, HLA-A3-restricted peptide epitopes were screened from hTERT and tested for immunogenicity in a human in vitro T-cell system. (aacrjournals.org)
  • HLA-A^*3303-rectricted CTL recognized 10-mer epitope ending Arg while HLA-A^*3101 -rectricted CTL recognized 9-mer epitope ending the same Arg. (nii.ac.jp)
  • Journal Article] Clinical relevance of a newly identified HLA-A24-restricted minor histocompatibility antigen epitope derived from BCL2A1,ACC-1,in patients receiving HLA genotypically matched unrelated bone marrow transplant. (nii.ac.jp)
  • A gene in the human major histocompatibility complex class II region controlling the class I antigen presentation pathway. (springer.com)
  • The purpose of this study was to investigate the prospect of antigen specific immunotherapy against prostate cancer via the HLA class II pathway of immune recognition. (nih.gov)
  • These β-cells also expressed mRNA for Class II and Class II antigen presentation pathway components, but lacked the macrophage marker CD68. (diabetesjournals.org)
  • Human leukocyte antigen (HLA)-DQ has emerged as the alloantibody most frequently associated with the generation of de novo donor-specific antibody (DSA), antibody-mediated-rejection, and unfavorable transplantation outcome. (sigmaaldrich.com)
  • Here, we have described Pr20, a TCR mimic (TCRm) human IgG1 antibody that recognizes the cell-surface ALY peptide/HLA-A2 complex. (jci.org)
  • An afucosylated Fc form (Pr20M) directed antibody-dependent cellular cytotoxicity against PRAME+HLA-A2+ leukemia cells and was therapeutically effective against mouse xenograft models of human leukemia. (jci.org)
  • This unit describes screening for HLA‐B27 on peripheral blood lymphocytes using more than one HLA‐B27 monoclonal antibody to detect possible cross‐reactivity with non‐HLA‐B27 antigens. (currentprotocols.com)
  • Advances in desensitization therapy and immunosuppressants made kidney transplantation possible in a recipient who had incompatible blood type with donor or preformed antibody against donor human leukocyte antigen (HLA). (ovid.com)
  • 1) positive result in crossmatch test and/or (2) donor specific antibody with mean fluorescent intensity (MFI) over 5000 measured by Luminex single antigen assay. (ovid.com)
  • A recipient who had combined immunologic risk of blood type incompatibility and preformed antibody against donor HLA antigen presented comparable outcome to a patient who had one of these risk factors. (ovid.com)
  • The Tambur lab at the Comprehensive Transplant Center, Northwestern University, Chicago, is focusing on understanding the immunogenicity of HLA-DQ antigens and its role in antibody-mediated rejection in solid organ transplantation," said Dr. Tambur. (californianewswire.com)
  • The presence of HLA specific antibody in the eluates was investigated. (surrey.ac.uk)
  • Some HLA specific sera still reacted against some pigs after removal of natural antibody and no reactivity was identical to any other. (surrey.ac.uk)
  • In addition, the presence of a non-HLA antibody was also found. (surrey.ac.uk)
  • The HLA-DR antigen was demonstrated by the mouse monoclonal antibody OKIa by a peroxidase-antiperoxidase method performed on glass slides. (uni-regensburg.de)
  • The serotype is determined by the antibody recognition of α11 subset of HLA-A α-chains. (wikipedia.org)
  • Our collaboration with Pure Transplant Solutions allows us to develop unique approaches to study the unique involvement of HLA-DQ in transplant immunology. (californianewswire.com)
  • Because the HLA is a chemical tag that distinguishes "self" from "nonself," the antigen is important in the rejection of transplanted tissue and in the development of certain diseases (e.g., insulin-dependent diabetes). (encyclopedia.com)
  • Defects in the structure of the HLAs is the cause of some diseases where the body's immune system perceives a host antigen as foreign and begins to attack the body's own tissue. (encyclopedia.com)
  • HLA testing is also used to match donated tissue with a person's tissue who is getting an organ transplant. (medlineplus.gov)
  • Human leukocyte antigen (HLA) testing is also called HLA typing or tissue typing. (cancer.ca)
  • A pattern of antigens, called a tissue type, is inherited from your parents. (cancer.ca)
  • The HLA system is used to assess tissue compatibility. (thefreedictionary.com)
  • DO was discovered in association with another chaperone HLA-DM (DM) but unlike DM, its distribution is more tissue specific, and its function more subtle. (frontiersin.org)
  • A clear understanding of the differences between HLA polymorphisms has provided ample insight into why and how foreign tissue is rejected by the host, and as such been a critical enabler of the field of transplantation. (bio-medicine.org)
  • Today, a variety of techniques are applied for HLA tissue typing, providing an important tool to increase the success rate of human transplants. (bio-medicine.org)
  • Furthermore, we provide evidence that HLA-G expressed in this tissue may associate with a subset of insulin-containing granules and may be shuttled to the cell surface in response to secretory stimuli. (diabetesjournals.org)
  • Interestingly, these tissues represent immunologically protected sites (the fetal trophoblast), sites of immune privilege (the anterior chamber of the eye and the testis), or lymphocyte selection (the thymus), suggesting a role for HLA-G in tissue-specific immunoregulation. (diabetesjournals.org)
  • After solubilization of tumor tissue and specific immunoprecipitation of classic HLA-A, -B, and -C and nonclassic HLA-G antigens the tumor samples were analyzed by one-dimensional isoelectric focusing (1D-IEF) and Western blot analysis. (arvojournals.org)
  • HLA-C and -G antigens were not found in uveal melanoma tissue implying a susceptibility for NK lysis. (arvojournals.org)
  • Many pathways of immune escape are known, including signaling defects in T cells, contact-induced anergy of T cells, and downregulation of HLA expression in tumor tissue. (arvojournals.org)
  • These preliminary data support a role for tissue matching in cadaver transplantation and suggest that combined matching for HLA AB and DR antigens may be more useful than matching for either alone. (mdedge.com)
  • The differences between placental (fetal) Mφ and adult peritoneal Mφ may reflect both tissue-specific differences and generally diminished class II antigen expression on fetal and neonatal mononuclear phagocytes. (caltech.edu)
  • Cytotoxic T lymphocytes(CTL) specific for minor histocompatibility antigens(mHAgs) whose tissue expression is limited to hematopoietic cells are useful for immunotherapy of relapsed leukemia/lymphoma following allogeneic hematopoietic cell transplantation(HCT). (nii.ac.jp)
  • In the present study we have tested the possibility of the role of 14bp insertion / deletion polymorphism of HLA-G in cancer progression and susceptibility. (aacrjournals.org)
  • Classical class I and class II Human Leukocyte Antigen (HLA) are leading candidates for infectious disease susceptibility. (antibodies-online.com)
  • Many observations point to a major role for classical HLA loci in determining susceptibility to viral infections 1 . (antibodies-online.com)
  • Analysis of HLA DR2&DQ6 (DRB1*1501, DQA1*0102, DQB1*0602) haplotypes in Iranian patients with multiple sclerosis. (harvard.edu)
  • Major Histocompatibility Complex Class II DR Beta 1 also known as HLA-DRB1 ia a member of the HLA class II beta chain paralogs. (prospecbio.com)
  • HLA-DRB1 produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 207 amino acids (30-227a.a.) and having a molecular mass of 24.0kDa. (prospecbio.com)
  • HLA-DRB1 is expressed with a 9 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques. (prospecbio.com)
  • HLA-DRB1 protein solution (0.25mg/ml) contains Phosphate Buffered Saline (pH 7.4) and 30% glycerol. (prospecbio.com)
  • We investigated HLA DRB1 correlations with chronic lymphocytic leukemia (B-CLL) outcome in 90 patients. (haematologica.org)
  • HLA DRB1*01 and HLA DRB1*02-null were associated with shorter overall survival ( p =0.007, p =0.002). (haematologica.org)
  • Allelic frequencies of HLA DRB1 were systematically examined in 90 B-CLL patients seen in the Department of Hematology during 2003-2004 for control visits, and in 94 ethnically-matched, healthy controls. (haematologica.org)
  • The HLA DRB1 allelic frequencies and distributions were consistent with the Hardy-Weinberg equilibrium, and did not differ significantly between CLL patients and the control group. (haematologica.org)
  • We were therefore unable to detect previously reported associations of HLA DRB1*0401 and DRB1*0403 with CLL incidence, or DRB3 (DR52) and DRB4 (DR53) supertypical loci with age-at-onset of CLL. (haematologica.org)
  • In a multivariate Cox regression model, the HLA DRB1*01 remained an independent factor predicting for shorter OS (p=0.005, relative risk [RR]= 3.84). (haematologica.org)
  • Coordinate defects in human histocompatibility leukocyte antigen class II expression and antigen presentation in bare lymphocyte syndrome. (springer.com)
  • For many years HLA polymorphisms were typed by serological respons. (bio-medicine.org)
  • The second HLA DNA typing technique is to use the PCR amplification reaction directly to detect HLA polymorphisms. (bio-medicine.org)
  • Therefore, 61 RSA couples (with three or more spontaneous abortions) and 47 fertile control couples were HLA‐G genotyped by direct DNA sequencing and analyzed for specific polymorphisms. (deepdyve.com)
  • Essentially the different HLA arrangement on cells allows the immune system to develop an inventory of "self" antigens in the body. (encyclopedia.com)
  • In the future, an invading organism that possesses one or some of these "non-self" antigens will be swiftly recognized as an invader and will be dealt with. (encyclopedia.com)
  • Regulatory CD4 + T cells are another specialized subset that plays a fundamental role in the maintenance of immune tolerance to self-antigens. (frontiersin.org)
  • Besides CD4 + effector cells, CD4 + regulatory T cells (Tregs), consisting of thymus-derived or induced cells, maintain peripheral tolerance to self-antigens by regulating other types of immune cells ( 3 ). (frontiersin.org)
  • Tumor-associated antigens (TAA) are monomorphic self-antigens that are proposed as targets for immunotherapeutic approaches to treat malignancies. (onmedica.com)
  • We investigated whether T cells with sufficient avidity to recognize naturally overexpressed self-antigens in the context of self-HLA can be found in the T-cell repertoire of healthy donors. (onmedica.com)
  • These results illustrate that self-HLA-restricted T cells specific for self-antigens like MiHA in MiHApos donors and TAA are present in peripheral blood of healthy individuals, but clinical efficacy would require highly effective in-vivo priming by peptide vaccination in the presence of proper adjuvants or in-vitro expansion of the low numbers of self-antigen-specific T cells of sufficient avidity to recognize endogenously processed antigen. (onmedica.com)
  • HLA-B27 is a blood test to look for a protein that is found on the surface of white blood cells. (medlineplus.gov)
  • It is a blood test that identifies antigens on the surface of cells and tissues. (cancer.ca)
  • HLA-B27 is a human leukocyte antigen that helps the body differentiate its own cells from foreign substances. (reference.com)
  • Human leukocyte antigens help regulate the immune system, and their main role is to let the body tell the difference between normal cells and substances that it needs to attack, states MedlinePlus. (reference.com)
  • The presentation of antigen to T cells requires that the antigens first be processed prior to presentation. (springer.com)
  • Assembly and intracellular transport of HLA-DM and correction of the class II antigen-processing defect in T2 cells. (springer.com)
  • These Antigens are polymorphic Glycoproteins comprising alpha and beta chains and are found on lymphoid and other Cells , often associated with certain Diseases . (online-medical-dictionary.org)
  • Fais S, Pallone F, Squarcia O, et al: HLA-DR antigens on colonic epithelial cells in inflammatory bowel disease: I. Relation to the state of activation of lamina propria lymphocytes and to the epithelial expression of other surface markers. (springer.com)
  • McDonald GB, Jewell DP: Class II antigen (HLA-DR) expression by intestinal epithelial cells in inflammatory diseases of colon. (springer.com)
  • Darr AS, Fuggle SV, Ting A, et al: Anomolous expression of HLA-DR antigens on human colorectal cancer cells. (springer.com)
  • Malfunctions during any step of antigen processing could lead to the development of self-reactive T cells or defective immune response to pathogens. (frontiersin.org)
  • Although much has been accomplished regarding how antigens are processed and presented to T cells, many questions still remain unanswered, preventing the design of therapeutics for direct intervention with antigen processing. (frontiersin.org)
  • Primary dendritic cells (DCs) also to express HLA-DO. (rcsb.org)
  • D ) In US2+ cells, HLA-A2 heavy chains are rapidly targeted for dislocation from the ER to the cytosol, where they are deglycosylated before proteasomal degradation. (pnas.org)
  • Adoptive cell therapy (ACT) is an emerging approach that necessitates defining robust and efficient methods for the in vitro expansion of antigen-specific T cells then infused into patients. (frontiersin.org)
  • To address this challenge, artificial antigen presenting cells (AAPCs) have been developed. (frontiersin.org)
  • They constitute a reliable and easily usable platform to stimulate and amplify antigen-specific CD4 + T cells. (frontiersin.org)
  • Finally, we discuss the potential interest of these AAPCs, both as fundamental tools to decipher CD4 + T cell responses and as reagents to generate clinical grade antigen-specific CD4 + T cells for immunotherapy. (frontiersin.org)
  • Surface expression of this HLA determinant in endocrine cells is regulated in response to growth and inflammatory stimuli. (diabetesjournals.org)
  • Thus, HLA-G presentation by endocrine cells may be regulated in concert with their secretory activity. (diabetesjournals.org)
  • The latter feature characterizes the expression of HLA-G. Thus, high levels of HLA-G were described in the blastocyst and the fetal cytotrophoblast during the 1st trimester of pregnancy, the epithelial cells of the anterior chamber of the eye, the testis, and the fetal liver ( 3 ). (diabetesjournals.org)
  • In addition, we have reported a restricted expression of HLA-G within the thymus in a select subset of medullary and subcortical epithelial cells ( 4 ). (diabetesjournals.org)
  • In support of this hypothesis, it was demonstrated that presentation of HLA-G on target cells downregulates effector functions in NK cells, antigen-specific CD8 + T cells, and monocytes through engagement of inhibitory receptors expressed on effector cells ( 5 - 9 ). (diabetesjournals.org)
  • Hence, it was shown that transgenic expression of viral antigens within pancreatic islets does not elicit an immune response even in the face of circulating autoreactive T-cells ( 10 ). (diabetesjournals.org)
  • Here we present a nanoparticle delivery system that facilitates presentation of an immunogenic measles antigen specifically in cancer cells. (sri.com)
  • Treatment with this system facilitates activation of a secondary immune response against cancer cells, bypassing the need to identify tumor-associated antigens or educate the immune system through a primary immune response. (sri.com)
  • Cytotoxic T cells directed to tumor antigens not expressed on normal melanocytes dominate HLA-A2.1-restricted immune repertoire to melanoma. (jimmunol.org)
  • CTL clones from three of the four subsets did not lyse melanocytes, but recognized fresh HLA-A2.1+ melanomas and defined three classes of epitopes, including unique Ags, common melanoma Ags, and Ags shared with neoplastic cells of different histologic origin. (jimmunol.org)
  • By a limiting dilution assay, designed to evaluate the frequency of HLA-A2-restricted CTL precursors (CTLp) directed to melanoma but not to melanocytes, such precursors were found in the peripheral blood or tumor site of five of six HLA-A2.1+ melanoma patients, and their frequency was much higher than the frequency of CTLp recognizing both tumor cells and the melanocytes. (jimmunol.org)
  • These results suggest that in melanoma patients most of the HLA-A2.1-restricted immune repertoire to melanoma is directly to epitopes expressed in the neoplastic but not in the normal cells of the melanocyte lineage. (jimmunol.org)
  • Cancerous cells start expressing HLA-G which in turn provides a shield for various immune responses. (aacrjournals.org)
  • β-Cell surface expression of HLA Class II was detected on a portion of CD45 − insulin + β-cells from donors with type 1 diabetes by immunofluorescence and flow cytometry. (diabetesjournals.org)
  • Long-term maintenance of HLA-D restricted T cells specific for soluble antigens. (diva-portal.org)
  • Melanoma cells derived from the other 2 patients showed neither surface expression of the HLA-A2 antigen nor presence of the corresponding mRNA. (aacrjournals.org)
  • TIL derived from patients whose melanoma cell lines had normal expression of HLA-A2 had a CD8 phenotype and were capable of lysing autologous melanoma cells. (aacrjournals.org)
  • In an attempt to restore HLA-A2 antigen expression in one of the melanoma cell lines that were HLA-A2 negative, we transfected these cells with the HLA-A2 gene subcloned in the pSV2-neo vector. (aacrjournals.org)
  • However, we observed selective recognition of the HLA-A2 expressing clones by autologous cultured peripheral blood lymphocytes (which contained CD8 cells) as well as allogeneic CD8 + TIL with a HLA-A2 restricted pattern of recognition. (aacrjournals.org)
  • Overall, our data suggest that selective down-regulation of HLA-A2 antigen expression in melanoma cells may represent one of the mechanisms by which tumor cells escape immunological recognition. (aacrjournals.org)
  • Because the expression of classic and nonclassic HLA antigens is crucial for the recognition and elimination of tumor cells by cytotoxic T and/or NK cells, we analyzed the HLA-A, -B, -C, and -G expression in uveal melanoma specimens from 18 patients. (arvojournals.org)
  • A considerable portion of the uveal melanomas tested showed a loss of classic HLA class I antigens, which may enable them to escape from the immunosurveillance of cytotoxic T cells. (arvojournals.org)
  • In damaged cells, such as virally infected or tumour cells, down-regulation of HLA-A, HLA-B and HLA-C production or inhibition of TAP prevents stabilization of HLA-E by the leader peptide. (portlandpress.com)
  • Under these circumstances, HLA-E does not reach the cell surface and the cell is then vulnerable to lysis by natural killer cells. (portlandpress.com)
  • A nine-amino acid peptide derived from hTERT binds strongly to HLA-A2 antigen and elicits CTL responses against a broad panel of hTERT + tumors (but not hTERT + hematopoietic progenitor cells). (aacrjournals.org)
  • In contrast, highly enriched HLA-A3 + CD34 + peripheral blood progenitor cells or activated T cells were not lysed. (aacrjournals.org)
  • The effect of donor lymphocyte infusion is mediated by donor T cells recognizing minor histocompatibility antigens. (haematologica.org)
  • T cells recognizing hematopoietic restricted minor histocompatibility antigens may induce selective graft- versus -leukemia reactivity, whereas broadly-expressed antigens may be targeted in graft- versus -host disease. (haematologica.org)
  • Results Three antigens were demonstrated to be expressed on primary leukemic cells of various origins as well as subtypes of non-malignant hematopoietic cells, whereas one antigen was selectively recognized on malignant hematopoietic cells with antigen presenting cell phenotype. (haematologica.org)
  • All antigens may have contributed to a graft- versus -leukemia effect, and one minor histocompatibility antigen (LB-SWAP70-1Q) has specific therapeutic value based on its in vivo immunodominance and strong presentation on leukemic cells of various origins, but absence of expression on cytokine-treated fibroblasts. (haematologica.org)
  • We and others recently demonstrated that Whole Genome Association scanning (WGAs) is an efficient method for high throughput identification of MiHA, 8 - 12 illustrated by the discovery of 10 novel MiHA as targets for CD8 + T cells in 2 different patients with leukemia who responded to DLI after HLA-matched alloSCT. (haematologica.org)
  • To improve the immunogenicity of exosomes as cancer vaccine, we prepared exosomes from heat-stressed carcinoembryonic antigen (CEA)-positive tumor cells (CEA + /HS-Exo) and tested the efficacy of these exosomes in the induction of CEA-specific antitumor immunity. (aacrjournals.org)
  • Moreover, in vitro incubation of lymphocytes from HLA-A*0201 + healthy donors and HLA-A*0201 + CEA + cancer patients with CEA + /HS-Exo-pulsed autologous dendritic cells induces HLA-A*0201-restricted and CEA-specific CTL response. (aacrjournals.org)
  • Exosomes derived from tumor antigen peptide-pulsed dendritic cells elicit potent tumor-specific immune responses ( 12 ). (aacrjournals.org)
  • Exosomes derived from tumor cells are also a source of shared tumor rejection antigens for CTL cross-priming in animal model ( 13 ). (aacrjournals.org)
  • HSP70 prepared from tumor cells or virus-infected cells can elicit potent antigen-specific CD8 + CTL response and therapeutic effects. (aacrjournals.org)
  • Evidence has revealed that by priming antigen-presenting cells, especially dendritic cells, HSP70 exhibits potent adjuvant functions in stimulating the host immune response ( 19 - 23 ) and has a potent antitumor effect in animal model ( 21 - 23 ). (aacrjournals.org)
  • A Minority of T Cells Recognizing Tumor-Associated Antigens Presented in Self-HLA Can Provoke Anti-Tumor Reactivity. (onmedica.com)
  • Minor histocompatibility antigen (MiHA)-specific T cells were used as model, as the influence of thymic selection on the T-cell repertoire directed against MiHA can be studied in both self (MiHApos donors)and non-self (MiHAneg donors) backgrounds. (onmedica.com)
  • Of the 16 unique HA-1H-specific T-cell clones, 5 T-cell clones derived from HA-1Hneg/HLA-A*02:01pos donors and 1 T-cell clone derived from an HA-1Hpos/HLA-A*02:01pos donor showed reactivity against HA-1Hpos target cells. (onmedica.com)
  • The effect of recombinant human interferon gamma (IFN-gamma) on the induction of HLA class II (HLA-DR, -DP, -DQ) antigen expression on human corneal epithelial (HCE) cells was examined in different stages of culture. (arvojournals.org)
  • Class II antigens were not detected on HCE cells in either stage without IFN-gamma treatment. (arvojournals.org)
  • IFN-gamma induced three class II antigens on HCE cells in both stages in a dose- and time-dependent manner but at different levels for each antigen (DR greater than DP greater than DQ). (arvojournals.org)
  • These findings indicate that the induction of class II antigens on HCE cells may be regulated by IFN-gamma independently for each of the antigens and that DQ induction may depend upon the differentiation of HCE cells in culture. (arvojournals.org)
  • Evidence to support the role of HLA-G5 in allograft acceptance through induction of immunosuppressive/ regulatory T cells. (semanticscholar.org)
  • HLA-E protects glioma cells from NKG2D-mediated immune responses in vitro: implications for immune escape in vivo. (semanticscholar.org)
  • We next attempted to identify a gene encoding HLA-A^*3303 restricted, male specific mHAg using a CTL clone that preferentially lysed hematopoietic cells. (nii.ac.jp)
  • Mouse monoclonal to HLA-DR.HLA-DR a human class II antigen of the major histocompatibility complex(MHC),is a transmembrane glycoprotein composed of an alpha chain (36 kDa) and a beta subunit(27kDa) expressed primarily on antigen presenting cells:B cells, monocytes, macrophages and thymic epithelial cells. (cylch.org)
  • HLA-DR is also expressed on activated T cells. (cylch.org)
  • In previous studies, genetically engineered K562 have been used to generate artificial antigen presenting cells (AAPC). (ovid.com)
  • CoEX-A2s were capable of stimulating antigen-specific CD8+ T cells both directly and indirectly via CoEX-A2 cross-dressed cells. (ovid.com)
  • The results suggest that these novel exosomes may provide a crucial reagent for generating antigen-specific CD8+ T cells for adoptive cell therapies against viral infection and tumors. (ovid.com)
  • Those T cells recognize the invaders antigen with their own HLA-class lmolecules. (nii.ac.jp)
  • later, the viable cells (T cells) were examined for their cytotoxic activity against peptide pulsed target cells (HLA-B35 Transfectant) by Chromium 51 release assay. (nii.ac.jp)
  • 2. Search for the major T cell antigens recognized by human T cells from the patients in the endemic area. (nii.ac.jp)
  • The expression of HLA-DR (Ia-like) antigens on human macrophages was investigated by analyses of cells from bronchoalveolar lavage fluid obtained from 12 patients with pulmonary sarcoidosis, six patients with extrinsic allergic alveolitis, nine patients with cryptogenic fibrosing alveolitis, 11 normal non-smokers, and 12 normal smokers. (uni-regensburg.de)
  • The serum of 100 patients with myasthenia gravis and 441 of their first-degree relatives was studied for the presence of autoantibodies against several antigens. (bmj.com)
  • Fig. 5: MARIA identifies lymphoma immunoglobulin HLA-DR presentation hotspots in patients with MCL. (nature.com)
  • Patients may get an HLA-B27 antigen test to find the cause of joint swelling and pain. (reference.com)
  • Antigen HLA-A29 was present in 16 of 20 patients (80%) with birdshot retinochoroidopathy, but only in 31 of 418 controls (7.4%) (P less than .0001). (nih.gov)
  • Of the 20 patients, 13 were also tested for evidence of an in vitro mitotic immune response to purified retinal S-antigen. (nih.gov)
  • 1. Human leucocyte AB antigens were determined by means of a lymphocyte toxicity test in 84 patients with essential hypertension and in 1000 blood donors. (clinsci.org)
  • 2. The prevalence of HLA B8 was 16.4% in hypertensive patients and 8.9% in controls ( P = 0.07). (clinsci.org)
  • 3. The prevalence of HLA B12 was 34.5% in hypertensive patients and 26.9% in the control group (N.S.). In WHO stage III hypertension HLA B12 was found in six out of 10 patients. (clinsci.org)
  • 6. A positive family history of hypertension tended to be more common in those patients with essential hypertension associated with HLA B8. (clinsci.org)
  • Serum soluble HLA class I antigen levels in hemodialysis patients and following renal transplantation. (biomedsearch.com)
  • To determine whether HLA-A21 restricted melanoma Ags exist that are not expressed on normal melanocytes, a panel of 478 T cell clones from six HLA-A21+ patients was selected for HLA-A2 restricted lysis of autologous tumor and then tested for differential recognition of HLA-A2.1+ melanomas and normal melanocytes. (jimmunol.org)
  • BACKGROUND: Alveolar macrophages from patients with sarcoidosis express increased quantities of HLA-DR during activation. (bmj.com)
  • METHODS: The relation between silver staining patterns of nucleoli and HLA-DR antigen expression was examined in alveolar macrophages collected by bronchoalveolar lavage from 11 patients with pulmonary sarcoidosis and 11 control subjects. (bmj.com)
  • The number of silver stained dots in alveolar macrophages correlated significantly with the intensity and the density of HLA-DR antigen expression in the patients with sarcoidosis. (bmj.com)
  • HLA-B27 is found in 90% of patients with ankylosing spondylitis and 80% in Reiter's disease. (specialtylabs.com)
  • Three common gp100 epitopes have been identified that are recognized in the context of HLA-A2 by TIL from different patients: G9154 (KTWGQYWQV), G9209 (ITDQVPFSV), and G9280 (YLEPGPVTA). (jimmunol.org)
  • Aim: The aims of this study were to deter- mine if there is an HLA-AP association in Lebanese patients, and to determine CRP levels in patients and compare them to those in healthy controls. (scirp.org)
  • Chakhtoura, M. , Souccar, N. , Al-Akl, N. and Abdelnoor, A. (2011) Human leukocyte antigen associations and c-reactive protein levels in lebanese patients with aggressive periodontitis-HLA and CRP in aggressive periodontitis. (scirp.org)
  • Cullinan, M.P., Sachs, J., Wolf, E. and Seymour, G.J. (1980) The distribution of HLA-A and -B antigens in patients and their families with periodontitis. (scirp.org)
  • Because of the recent demonstration that expression of HLA Class I antigens may be selectively lost in several human tumors, including melanoma, we derived pairs of tumor infiltrating lymphocytes (TIL) and melanoma cell lines from 4 human lymphocytic antigen (HLA)-A2 + patients with metastatic melanoma. (aacrjournals.org)
  • On the other hand, TIL derived from the 2 patients whose melanoma cell lines had lost expression of HLA-A2 had a predominant CD4 phenotype and virtually no cytotoxic activity. (aacrjournals.org)
  • In parallel, patients were typed for HLA-A, -B, and -C class I antigens by PCR with sequence-specific primers (PCR-SSP). (arvojournals.org)
  • In addition, HLA-A2 and -G expression was investigated by immunohistochemistry in paraffin-embedded tumor sections from these patients. (arvojournals.org)
  • I have 3 patients with HLA 17-2-52B that seem to have biotoxin illness. (survivingmold.com)
  • We have looked at the per cent of non-HLA susceptible patients with confirmed mold illness. (survivingmold.com)
  • We analyzed the graft survival according to presence of rejection episode, the result was inferior in patients who had rejection episode, but there was not statistical significance (p=0.102) We compared graft survival of presented patients with standard ABOi KT patients (n=88) and sensitized to donor HLA antigen patients (n=51) performed same period in our institute and there was no statistical significance (p=0.788). (ovid.com)
  • The hTERT peptide K973 was used to generate specific CD8 + CTLs from HLA-A3 + cancer patients and healthy individuals. (aacrjournals.org)
  • Background Patients with hematologic malignancies can be successfully treated with donor lymphocyte infusion after HLA-matched allogeneic hematopoietic stem cell transplantation. (haematologica.org)
  • The focus of the collaboration is to develop and test novel HLA reagents created by PTS that may be used for enhanced analysis and characterization of DQ antigens, an HLA Class II type that is increasingly gaining importance in causing rejection in transplant patients. (californianewswire.com)
  • Then, we evaluated their ability to induce a CEA-specific immune response in vivo in HLA-A2.1/K b transgenic mice and CEA-specific CTL response in vitro in HLA-A*0201 + healthy donors and HLA-A*0201 + CEA + cancer patients. (aacrjournals.org)
  • To further evaluate the nature of the HLA association with psoriasis, HLA haplotypes of 60 patients with type 1 (early onset, positive family history) and 30 patients with type II (late onset, no family history) psoriasis were investigated by polymerase chain reaction sequence-specific oligonucleotide hybridization (HLA class II) and serology (HLA class I). Ethnically matched blood donors (146) served as controls. (diva-portal.org)
  • This is a retrospective analysis of the results of HLA AB and DR antigen matching in 56 transfused cadaver transplant patients. (mdedge.com)
  • Histocompatibility (HLA) antigen phenotypes have been studied in 100 patients with ulcerative colitis, 100 with Crohn's disease, and 283 normal controls. (bmj.com)
  • There was no significant difference in antigen frequency between patients and controls. (bmj.com)
  • However, the incidence of HLA-B27 was increased in the patients complicated by ankylosing spondylitis and/or sacroiliitis in both ulcerative colitis and Crohn's disease. (bmj.com)
  • In contrast, none of the 29 IBD patients with "enteropathic" peripheral arthropathy had B27 antigen. (bmj.com)
  • Furthermore, ankylosing spondylitis was found more frequently in ulcerative colitis bearing HLA-B27 compared with non-B27 patients (P less than 0-01). (bmj.com)
  • In addition, 12 of 14 ulcerative colitis patients and five out of six Crohn's patients with HLA-B27 had total colitis, compared with the frequency of total colitis in non-B27 patients (P less than 0-024 and less than 0-03 respectively). (bmj.com)
  • NY-ESO-1 is a member of the cancer-testis family of tumor antigens that elicits strong humoral and cellular immune responses in patients with NY-ESO-1-expressing cancers. (uzh.ch)
  • The characterization of HLA class II-restricted epitopes will be useful for the assessment of spontaneous and vaccine-induced immune responses of cancer patients against defined tumor antigens. (uzh.ch)
  • First we examined the impact of BCL2A1/A24 disparity on clinical outcome using 320 HLA-A24-positive patients receiving HLA-identical HCT.donor pairs. (nii.ac.jp)
  • Publications] Kenji Hirayama: 'T-Lymphoproliferative response of the patients with Chagas'desease to epimastigote antigen of T. curuzi in GUATEMALA' Jpn. (nii.ac.jp)
  • Publications] Kenji Hirayama: 'T-Lympho-proliferative response of the patients with Chagas' disease to epimastigote antigen of T.cruzi in Guatemala' Jpn.J.Trop.Med.Hyg. (nii.ac.jp)
  • Publications] Kenji Hirayama: 'T-Lymphoproliferative response of the patients with Chagas' disease to epimastigote antigen of T.cruzi in Gatemala' Jpn.J.Parasit.44 Suppl. (nii.ac.jp)
  • One hundred and fourteen Chinese patients with hepatocellular carcinomas (HCC) were studied for α-fetoprotein (AFP), hepatitis B surface antigen (HBsAg), anti-HBsAg, and HLA markers. (nus.edu.sg)
  • A higher frequency of HLA-B38 was noted psoriatic arthritis patients with erythroderma. (wikipedia.org)
  • HLA-I Antigen Presentation and Tapasin Influence Immune Responses Against Malignant Brain Tumors - Considerations for Successful Immunotherapy. (lu.se)
  • Loss of HLA class I expression in prostate cancer: implications for immunotherapy. (semanticscholar.org)
  • The protein is called human leukocyte antigen B27 (HLA-B27). (medlineplus.gov)
  • A type of protein made by the immune system that disarms or destroys a specific foreign substance (antigen) when it appears in the body. (cancer.ca)
  • Human Leukocyte antigen -G is an immunosuppressive protein with multiple functions. (aacrjournals.org)
  • Protein microarray is a screening tool that reproducibly detects serums reactivities to non-HLA antigens. (asnjournals.org)
  • Pure Transplant Solutions, LLC was founded in 1999 in order to leverage the leading research in HLA protein of parent company, Pure Protein, LLC, into solutions to address a growing list of needs in organ transplantation. (californianewswire.com)
  • Pure Protein, LLC is a biotechnology company funded and managed by Emergent Technologies, Inc. that is focused on the development and commercialization of proprietary technologies related to the human leukocyte antigen (HLA) system, formed and exclusively licensed from the University of Oklahoma. (californianewswire.com)
  • We pay special attention to the HLA-I dedicated multifunctional protein, tapasin, and in relation to the different tapasin-dependency of HLA-I allomorphs we also discuss allomorph specific traits in maturation, structure and linkage to malignant diseases and brain tumors in particular. (lu.se)
  • The complete structure and gene map of the HLA region have been published [ 1,2 ]. (uptodate.com)
  • A gene required for class II restricted antigen presentation maps to the major histocompatibility complex. (springer.com)
  • Third, identification of mHAg gene(s) encoding HLA-A^*3303 and -A^*3101-restricted mHAgs was conducted. (nii.ac.jp)
  • Journal Article] A Novel HLA-A^*3303-restricted minor histocompatibility antigen encoded by an unconventional open reading frame of human TMSB4Y gene. (nii.ac.jp)
  • This recognition occurs because the HLA groups are "read" by an immune cell called the T cell . (encyclopedia.com)
  • Antigen presentation profiling reveals recognition of lymphoma immunoglobulin neoantigens. (nature.com)
  • It has been suggested that the maternal NK recognition of this downregulation is balanced by the expression of HLA-G, thus preventing damage to the placenta. (rupress.org)
  • Previous studies have suggested that, in human melanoma, expression of HLA-A2 antigen is important for tumor cell recognition by autologous T-lymphocytes. (aacrjournals.org)
  • However, little is known about HLA-DQ8 transdimer-restricted CD4 T cell recognition, an event crucial for triggering HLA-DQ8 transdimer-specific anti-islet immunity. (sciencemag.org)
  • The generation of HLA-DQ de novo DSA was interrogated in 40 transplant recipients who were immunologically naive before their failed transplantation. (sigmaaldrich.com)
  • This will pave the way to identifying acceptable mismatches and will allow risk stratification for generating de novo HLA-DSA after transplantation. (sigmaaldrich.com)
  • We measured the serum levels of soluble HLA class I antigen (sHLA-I) to evaluate the immune status of uremia and following renal transplantation. (biomedsearch.com)
  • Rationale: Chemotherapy with fludarabine, cyclophosphamide and anti-thymocyte globulin may induce the engraftment cross the immunologic barrier in the setting of HLA-haploidentical allogeneic hematopoietic cell transplantation. (clinicaltrials.gov)
  • AUSTIN, Texas, Mar 17, 2021 (SEND2PRESS NEWSWIRE) - Pure Transplant Solutions, LLC (PTS), a collaboration driven biotechnology company focused on the development of human leukocyte antigen (HLA)-based diagnostics and therapeutics within the field of transplantation, is proud to announce that it has entered into a collaboration agreement with Northwestern University, a world leader in HLA DQ antigen research. (californianewswire.com)
  • In the last years, we have seen a re-emerging role of HLA-DQ in transplantation medicine with increasing evidence that DQ mismatches between transplant recipient and donor are most detrimental to graft survival," said Dr. Buchli. (californianewswire.com)
  • Conditions such as arthritis, ankylosing spondylitis and inflammation of the sacroiliac joint may cause an increase in HLA-B27 and human leukocyte antigens, states MedlinePlus. (reference.com)
  • for example, HLA-B27 is usually present in people who have ankylosing spondylitis. (thefreedictionary.com)
  • Ankylosing spondylitis is 10 times more common among individuals with HLA-B27 compared to individuals without this antigen. (specialtylabs.com)
  • A group of the D-related HLA Antigens found to differ from the DR Antigens in Genetic Locus and therefore inheritance. (online-medical-dictionary.org)
  • However, the advent of recombinant DNA technology, which paved the way to identifying genetic differences among the HLA loci directly, has led many laboratories to abandon classic serological typing methods. (bio-medicine.org)
  • Our findings suggested that birdshot retinochoroidopathy has a genetic predisposition and that retinal autoimmunity, resulting from the S-antigen or other retinal antigens, plays a role in the manifestation of this disease. (nih.gov)
  • 5. In view of a previous report of HLA antigens in a Spanish diabetic population, this study does not support the suggestion of a genetic and possibly HLA-linked connection between essential hypertension and diabetes mellitus among the Spanish population. (clinsci.org)
  • Despite the contribution of HLA to the overall genetic risk has been estimated to range from 30% to 50%, it has never been studied in the French west-Indian population. (bioportfolio.com)
  • HLA-C at 6p21.33) in multi-ethnic populations with genetic heterogeneity and racial/ethnic differences among Caucasians, African-Americans, and Hispanics. (curehunter.com)
  • Although a tendency towards an association with a certain genetic type and with HLA-B51 is suspected, the incidence of several siblings with Behçet's disease in a single family is rare. (bmj.com)
  • Genetic aspect of venom allergy: association with HLA class I and class II antigens. (aaem.pl)
  • The detection of the HLA‐B27 antigen by immunomagnetic separation and enzyme‐linked immunosorbent assay: Comparison with a flow cytometric procedure. (currentprotocols.com)
  • Nine human liver specimens, known from light microscopic investigation to display membranous positivity for HLA Class I antigens, were processed for immunoelectronmicroscopy using monoclonal anti-HLA Class I in an indirect immunoperoxidase procedure. (kuleuven.be)
  • Class Ia HLAs, namely HLA-A, -B, and -C, are heterodimers comprising a 45-kDa polymorphic heavy chain noncovalently associated with an invariant light chain, β2-microglobulin. (diabetesjournals.org)
  • Antigens determined by leukocyte loci found on chromosome 6, the major histocompatibility loci in humans. (nih.gov)
  • In general, HLA DNA can be typed either by hybridizing labeled, sequence specific oligonucleotide probes to HLA loci amplified by the polymerase chain reaction (PCR), or by using PCR to amplify th e HLA DNA directly through differential primer extension. (bio-medicine.org)
  • for example, it is possible to construct PCR primers pre labeled with biotin, and then amplify biotin labeled HLA loci. (bio-medicine.org)
  • For those laboratories with access to Sequencers, it may be the most sensitive, specific and cost effective option to sequence certain HLA loci directly. (bio-medicine.org)
  • E ) Alignment of HLA-A2 with consensus heavy chain sequences of class I loci in the three regions contacted by US2. (pnas.org)
  • Furthermore, these antigens are not expressed in the placenta with the exception of HLA‐C. However, HLA‐G is expressed on especially invasive cytotrophoblasts and exists in both membrane and soluble forms. (deepdyve.com)
  • The characterization of hTERT as a polyepitope, polyallelic tumor-associated antigen may provide an approach for circumventing therapy-induced resistance potentially mediated by antigenic- and allelic-loss tumor escape mutants. (aacrjournals.org)
  • Routine HLA‐B27 typing by flow cytometry: Differentiation of the products of HLA‐B*2702, B*2705 and B*2708. (currentprotocols.com)
  • CD4 + TIL showed no difference in the proliferative response to autologous parental and HLA-A2 transfected clones. (aacrjournals.org)
  • The results will show the degree to which HLA antigens match between you and the donor. (rochester.edu)
  • They have significantly lower immunogenicity than the HLA-A and -B determinants and are therefore of minor importance in donor/recipient crossmatching. (curehunter.com)
  • We examined these surface antigens and a monocyte marker antigen on fresh cord and adult blood monocytes, macrophages (Mφ) derived from monocytes in vitro, human placental (fetal) Mφ, from adult women. (caltech.edu)
  • Natali PG, Martino CD, Quaranta V, et al: Expression of lalike antigens in normal human nonlymphoid tissues. (springer.com)
  • Chiba M, Iizuka M, Masamune O: Ubiquitous expression of HLA-DR antigens on human small intestinal epithelium. (springer.com)
  • Iizuka M, Chiba M, Ohta H, et al: Expression of HLA-DR antigens on colonic epithelium in ulcerative colitis. (springer.com)
  • Selby WS, Janossy G, Mason DY, et al: Expression of HLA-DR antigens by colonic epithelium in inflammatory bowel disease. (springer.com)
  • Disease progression despite protective HLA expression in an HIV-infected transmission pair. (harvard.edu)
  • Correlation of morphological patterns of nucleoli in alveolar macrophages with HLA-DR antigen expression in sarcoidosis. (bmj.com)
  • Because silver staining has been described as a sensitive indicator of cellular activity a study was performed to examine whether it relates to HLA-DR antigen expression. (bmj.com)
  • The +14bp/-14bp and −14bp/-14bp genotypes have already been shown to be associated with higher expression of HLA-G and its mRNA stability and might be providing favorable micro-environment for cancer progression. (aacrjournals.org)
  • We also observed some correlation between loss of HLA-A2 expression and level of c- myc transcription. (aacrjournals.org)
  • Preincubation of the HLA-A2 negative melanoma cell lines with α- or γ-interferon did not induce the re-expression of the HLA-A2 antigen. (aacrjournals.org)
  • Four transfected clones, with high levels of HLA-A2 antigen expression, were expanded and characterized. (aacrjournals.org)
  • Three to four parameters-forward scatter, side scatter, HLA‐B27 expression, and, in some cases CD3 or B7 expression-are acquired. (currentprotocols.com)
  • In 9 (50%) of 18 specimens, a full HLA-A and -B antigen expression pattern was detected by 1D-IEF. (arvojournals.org)
  • The purpose of this study was to specify the ultrastructural topography of HLA Class I antigens expression. (kuleuven.be)
  • Both the quantity and quality of peptide-HLA-I (pHLA-I) complexes are crucial for CTL responses, but the level of HLA-I expression per se is also directly involved in dictating NK-cell responses. (lu.se)
  • HLA class II antigen expression and IL-1 production by mononuclear phagocytes are important for antigen-stimulated T-cell activation. (caltech.edu)
  • These data indicate that class II antigen expression and IL-1 secretion by mononuclear phagocytes are only in part co-ordinately modulated. (caltech.edu)
  • Regulation of HLA class II antigen expression on cultured corneal epithelium by interferon-gamma. (arvojournals.org)
  • Tumor-specific up-regulation of the nonclassical class I HLA-G antigen expression in renal carcinoma. (semanticscholar.org)
  • Lack of human leukocyte antigen-G expression in extravillous trophoblasts is associated with pre-eclampsia. (semanticscholar.org)
  • Indeed much of the early knowledge of the antigen complex came from work on mice in the early decades of the twentieth century. (encyclopedia.com)
  • Human leukocyte antigen: the major histocompatibility complex of man. (medlineplus.gov)
  • The human leukocyte antigen (HLA) complex is synonymous with the human MHC. (uptodate.com)
  • Positioning of autoimmune TCR-Ob.2F3 and TCR-Ob.3D1 on the MBP85-99/HLA-DR2 complex. (harvard.edu)
  • Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL , leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). (rcsb.org)
  • The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. (rcsb.org)
  • Structure of the US2/HLA-A2/Tax complex and topology of the US2 Ig-like domain. (pnas.org)
  • The US2/HLA-A2/Tax complex and interaction surfaces. (pnas.org)
  • 2 The Human Leukocyte Antigen complex (HLA) is one of the inherited factors that influences the development of B-CLL and clinical outcome of diffuse large B-cell lymphoma. (haematologica.org)
  • Melanoma cell killing was CD3 and major histocompatibility complex Class I restricted in both cases, but HLA-A2 restricted in only one case. (aacrjournals.org)
  • Mutagenesis at the α chain of HLA-DQ8 transdimer in complex with the disease-relevant GAD65 250-266 peptide and in silico analysis reveal the DQ α52 residue located within the N-terminal edge of the peptide-binding cleft for the enhanced T cell reactivity, altering avidity and biophysical affinity between TCR and HLA-peptide complexes. (sciencemag.org)
  • Major histocompatibility complex products Class I (HLA Class I) antigens are not expressed on the surface of normal human hepatocytes but become so in pathological conditions. (kuleuven.be)
  • The recommended ELISA Kit will likely detect the antigen in question with higher specificity in approved samples than the available alternatives. (antibodies-online.com)
  • Knowing the "self" antigen allows the immune system to rapidly distinguish foreign antigens. (encyclopedia.com)
  • A large groove between the alpha-helices provides a binding site for processed foreign antigens. (nih.gov)
  • http://www.ebi.ac.uk/ipd/imgt/hla/ (Accessed on November 29, 2017). (uptodate.com)
  • Consensus sequences were obtained from the IMGT/HLA Sequence Database ( www.ebi.ac.uk/imgt/hla/align.html ). (pnas.org)
  • One of the most commonly employed strategies in HLA DNA typing is to first amplify a given HLA locus, then hybridize it with a labeled, sequence specific oligonucleotide probe. (bio-medicine.org)
  • 1) HLA-B35 might not be ideal for the analysis of immune response against the cysteine protease antigen due to row affintiy. (nii.ac.jp)
  • CD8 + T-cell clones specific for 4 HLA-B*40:01 restricted minor histocompatibility antigens were isolated which were identified by screening a plasmid cDNA library and whole genome association scanning. (haematologica.org)
  • Conclusions Our data show evidence for different roles of the HLA-B*40:01 restricted minor histocompatibility antigens in the onset and execution of the anti-tumor response. (haematologica.org)
  • Histocompatibility antigens in inflammatory bowel disease. (bmj.com)
  • Despite preservation of putative residues for T cell receptor (TCR) contact, stronger disease-associated responses to cross-reactive, immunodominant islet epitopes are elicited by HLA-DQ8 transdimer. (sciencemag.org)
  • We have produced T cell clones reactive to epimastigote antigen. (nii.ac.jp)
  • Horie Y, Chiba M, Iizuka M, et al: Colonie lymphoid cell subsets and epithelial HLA-DR antigens in familial polyposis coli. (springer.com)
  • HLA antigens in familial Guillain-Barré syndrome. (bmj.com)
  • HLA antigen familial study in complete Behçet's syndrome affecting three sisters. (bmj.com)